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Sample records for ps ii located

  1. Angiotensin II stimulates basolateral 50-pS K channels in the thick ascending limb.

    Science.gov (United States)

    Wang, Mingxiao; Luan, Haiyan; Wu, Peng; Fan, Lili; Wang, Lijun; Duan, Xinpeng; Zhang, Dandan; Wang, Wen-Hui; Gu, Ruimin

    2014-03-01

    We used the patch-clamp technique to examine the effect of angiotensin II (ANG II) on the basolateral K channels in the thick ascending limb (TAL) of the rat kidney. Application of ANG II increased the channel activity and the current amplitude of the basolateral 50-pS K channel. The stimulatory effect of ANG II on the K channels was completely abolished by losartan, an inhibitor of type 1 angiotensin receptor (AT1R), but not by PD123319, an AT2R antagonist. Moreover, inhibition of phospholipase C (PLC) and protein kinase C (PKC) also abrogated the stimulatory effect of ANG II on the basolateral K channels in the TAL. This suggests that the stimulatory effect of ANG II on the K channels was induced by activating PLC and PKC pathways. Western blotting demonstrated that ANG II increased the phosphorylation of c-Src at tyrosine residue 416, an indication of c-Src activation. This effect was mimicked by PKC stimulator but abolished by calphostin C. Moreover, inhibition of NADPH oxidase (NOX) also blocked the effect of ANG II on c-Src tyrosine phosphorylation. The role of Src-family protein tyrosine kinase (SFK) in mediating the effect of ANG II on the basolateral K channel was further suggested by the experiments in which inhibition of SFK abrogated the stimulatory effect of ANG II on the basolateral 50-pS K channel. We conclude that ANG II increases basolateral 50-pS K channel activity via AT1R and that activation of AT1R stimulates SFK by a PLC-PKC-NOX-dependent mechanism.

  2. Bacterial Bolsheviks: PS II and the Evolution of the Oxygenic Revolution

    Science.gov (United States)

    Kopp, R. E.; Kirschvink, J. L.; Newman, D. K.; Nash, C. Z.; Hilburn, I. A.

    2003-12-01

    After the rise of life itself, the most radical transformation of Earth's biogeochemical cycles was the transition from an anoxic to an oxic world. Though various studies have suggested O2 made its first bulk appearance in the atmosphere some time between 3.8 and 2.1 Ga, virtually all analyses agree the production of large quantities of free O2 was triggered by the evolution of oxygenic photosynthesis. We suggest the oldest strong geological evidence for O2 is the 2.22 Ga Kalahari Mn member of the Hotazel BIF (1), as in the oceans only free O2 can oxidize soluble Mn(II) into insoluble Mn(IV). Some have argued, however, that oxygenic cyanobacteria had originated by 2.7 Ga. The ˜500 Myr "gap" has often been interpreted as the timescale for gradual evolutionary improvement of the O2-generating system. Biochemical and genomic analyses of photosynthetic bacteria indicate that photosystems I and II, which operate together in cyanobacteria, had a long history of parallel development. Green sulfur bacteria and heliobacteria use PS-II, while green non-sulfur and purple bacteria use PS-I; none can use H2O as an electron donor. Recent genetic analyses show lateral gene transfer was rampant among photosynthetic lineages (2). Moreover, extant cyanobacteria shut down PS-II in the presence of an alternative electron donor like H2S. This suggests PS-I and PS-II came together with their functions intact. Hence, most `debugging' of the two systems predates their merger in the ancestor of modern cyanobacteria. The time interval between the lateral transfer events and the evolution of oxygenic photosynthesis could thus have been geologically short. We suggest the ˜500 Myr "gap" may result from misinterpretations. The presence of oxygenic photosynthesis is uncertain before the deposition of the Hotazel formation, in the aftermath of the Makganyene glaciation (1). A simple model of nutrient and reductant fluxes argues that, once triggered, the oxygenation of a reducing surface

  3. In vitro degradation of the 32kDa PS II reaction centre protein

    International Nuclear Information System (INIS)

    Eckenswiller, L.C.; Greenberg, B.M.

    1989-01-01

    The 32kDa thylakoid membrane protein is an integral component of the PS II reaction centre. The protein, although stable in the dark, undergoes light dependent turnover. Light from the UV, visible and far-red spectral regions induce 32kDa protein degradation. To better understand 32kDa protein metabolism, an in vitro degradation system is being developed. It consists of isolated thylakoid membranes than contain radiolabelled protein. The 32kDa protein is actively and specifically degraded when the thylakoid preparation is exposed to UV or visible radiation. The protein is stable in the dark. The herbicides (atrazine and DCMU) inhibit degradation in the in vitro system as they do in vivo. Additionally, several methods of isolating thylakoids are being compared to optimize the 32kDa protein degradation reaction. The preparations will be evaluated based on their ability to permit light dependent degradation of the 32kDa protein without affecting the other membrane components

  4. 1170-MW(t) HTGR-PS/C plant application study report: SRC-II process application

    International Nuclear Information System (INIS)

    Rao, R.; McMain, A.T. Jr.

    1981-05-01

    The solvent refined coal (SRC-II) process is an advanced process being developed by Gulf Mineral Resources Ltd. (a Gulf Oil Corporation subsidiary) to produce a clean, non-polluting liquid fuel from high-sulfur bituminous coals. The SRC-II commercial plant will process about 24,300 tonnes (26,800 tons) of feed coal per stream day, producing primarily fuel oil plus secondary fuel gases. This summary report describes the integration of a high-temperature gas-cooled reactor operating in a process steam/cogeneration mode (HTGR-PS/C) to provide the energy requirements for the SRC-II process. The HTGR-PS/C plant was developed by General Atomic Company (GA) specifically for industries which require energy in the form of both steam and electricity. General Atomic has developed an 1170-MW(t) HTGR-PS/C design which is particularly well suited to industrial applications and is expected to have excellent cost benefits over other sources of energy

  5. [PS II photochemical efficiency in flag leaf of wheat varieties and its adaptation to strong sun- light intensity on farmland of Xiangride in Qinghai Province, Northwest China].

    Science.gov (United States)

    Shi, Sheng-Bo; Chen, Wen-Jie; Shi, Rui; Li, Miao; Zhang, Huai-Gang; Sun, Ya-Nan

    2014-09-01

    Taking four wheat varieties developed by Northwest Institute of Plateau Biology, Chinese Academy of Sciences, as test materials, with the measurement of content of photosynthetic pigments, leaf area, fresh and dry mass of flag leaf, the PS II photochemistry efficiency of abaxial and adaxial surface of flag leaf and its adaptation to strong solar radiation during the period of heading stage in Xiangride region were investigated with the pulse-modulated in-vivo chlorophyll fluorescence technique. The results indicated that flag leaf angle mainly grew in horizontal state in Gaoyuan 314, Gaoyuan 363 and Gaoyuan 584, and mainly in vertical state in Gaoyuan 913 because of its smaller leaf area and larger width. Photosynthetic pigments were different among the 4 varieties, and positively correlated with intrinsic PS II photochemistry efficiencies (Fv/Fm). In clear days, especially at noon, the photosynthetic photoinhibition was more serious in abaxial surface of flag leaf due to directly facing the solar radiation, but it could recover after reduction of sunlight intensity in the afternoon, which meant that no inactive damage happened in PS II reaction centers. There were significant differences of PS II actual and maximum photochemical efficiencies at the actinic light intensity (ΦPS II and Fv'/Fm') between abaxial and adaxial surface, and their relative variation trends were on the contrary. The photochemical and non-photochemical quenching coefficients (qP and NPQ) had a similar tendency in both abaxial and adaxial surfaces. Although ΦPS II and qP were lower in adaxial surface of flag leaf, the Fv'/Fm' was significantly higher, which indicated that the potential PS II capture efficiency of excited energy was higher. The results demonstrated that process of photochemical and non-photochemical quenching could effectively dissipate excited energy caused by strong solar radiation, and there were higher adaptation capacities in wheat varieties natively cultivated in

  6. Isolation Of PS II Nanoparticles And Oxygen Evolution Studies In Synechococcus Spp. PCC 7942 Under Heavy Metal Stress

    Science.gov (United States)

    Ahmad, Iffat Zareen; Sundaram, Shanthy; Tripathi, Ashutosh; Soumya, K. K.

    2009-06-01

    The effect of heavy metals was seen on the oxygen evolution pattern of a unicellular, non-heterocystous cyanobacterial strain of Synechococcus spp. PCC 7942. It was grown in a BG-11 medium supplemented with heavy metals, namely, nickel, copper, cadmium and mercury. Final concentrations of the heavy metal solution used in the culture were 0.1, 0.4 and 1 μM. All the experiments were performed in the exponential phase of the culture. Oxygen-evolving photosystem II (PS II) particles were purified from Synechococcus spp. PCC 7942 by a single-step Ni2+-affinity column chromatography after solubilization of thylakoid membranes with sucrose monolaurate. Oxygen evolution was measured with Clark type oxygen electrode fitted with a circulating water jacket. The light on the surface of the vessel was 10 w/m2. The cultures were incubated in light for 15 minutes prior to the measurement of oxygen evolution. Oxygen evolution was measured in assay mixture containing phosphate buffer (pH-7.5, 0.1 M) in the presence of potassium ferricyanide as the electron acceptor. The preparation from the control showed a high oxygen-evolving activity of 2, 300-2, 500 pmol O2 (mg Chl)-1 h-1 while the activity was decreased in the cultures grown with heavy metals. The inhibition of oxygen evolution shown by the organism in the presence of different metals was in the order Hg>Ni>Cd>Cu. Such heavy metal resistant strains will find application in the construction of PS II- based biosensors for the monitoring of pollutants.

  7. VizieR Online Data Catalog: L/T transition dwarfs search with PS1 & WISE. II. (Best+, 2015)

    Science.gov (United States)

    Best, W. M. J.; Liu, M. C.; Magnier, E. A.; Deacon, N. R.; Aller, K. M.; Redstone, J.; Burgett, W. S.; Chambers, K. C.; Draper, P.; Flewelling, H.; Hodapp, K. W.; Kaiser, N.; Metcalfe, N.; Tonry, J. L.; Wainscoat, R. J.; Waters, C.

    2016-03-01

    We used the new Pan-STARRS1 Survey (PS1; Kaiser et al. 2010SPIE.7733E..0EK) detections through 2012 January cross-matched with the Wide-field Infrared Survey Explorer (WISE; Wright et al. 2010AJ....140.1868W) All-sky Release using a 3" matching radius. In Best et al. (2013ApJ...777...84B; Paper I), we presented seven initial discoveries from our search, all bright L/T transition dwarfs within 15pc. In this paper, we present the complete results of our search, including 79 total L/T transition dwarfs and 23 young or potentially young late-M and L dwarfs. The PS1 3π survey (K. C. Chambers et al. 2016AAS...22732407C) has obtained an average of ~12 epochs of imaging in five optical bands (gP1, rP1, iP1, zP1, yP1) with a 1.8-m wide-field telescope on Haleakala, Maui, covering the entire sky north of -30° declination. Imaging began in 2010 May and concluded in 2014 March. The WISE All-sky Source Catalog (Cutri et al. 2012, II/311) comprises data taken between 2010 January and August in four mid-infrared bands: W1 (3.6um), W2 (4.5um), W3 (12um), and W4 (22um). We searched the UKIDSS Data Release 9 (DR9; Lawrence et al. 2013, II/319) and VISTA Hemisphere Survey (Cross et al. 2012A&A...548A.119C) catalogs for JHK photometry of our candidates on the Mauna Kea Observatories (MKO) filter system. For objects not found in either survey, we obtained follow-up images using WFCAM on the 3.8m United Kingdom InfraRed Telescope (UKIRT) as part of the UKIRT Service Program. Observations took place on multiple nights spanning 2010 September to 2013 December. We obtained low-resolution near-IR spectra for our 142 candidates between 2012 July and 2014 January using the NASA IRTF/SpeX spectrograph (details of our observations are listed in table 3). (7 data files).

  8. HTLV-I/II prevalence in different geographic locations

    NARCIS (Netherlands)

    Vrielink, Hans; Reesink, Henk W.

    2004-01-01

    Human T-cell lymphotropic virus (HTLV) type I (HTLV-I) is the etiological agent of adult T-cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-II is a closely related virus, and this infection is not clearly associated with clinical disease, although

  9. Urban Property Taxation: II. Land and Location. Exchange Bibliography 480.

    Science.gov (United States)

    White, Anthony G.

    This is one of three related bibliographies listing publications dealing with the broad topic of property taxation. This particular volume concerns some specialized fields of study, including locational theory, land use and taxation, property markets and valuation, housing, and urban renewal and redevelopment. Citations are listed alphabetically…

  10. PS II model based analysis of transient fluorescence yield measured on whole leaves of Arabidopsis thaliana after excitation with light flashes of different energies.

    Science.gov (United States)

    Belyaeva, N E; Schmitt, F-J; Paschenko, V Z; Riznichenko, G Yu; Rubin, A B; Renger, G

    2011-02-01

    Our recently presented PS II model (Belyaeva et al., 2008) was improved in order to permit a consistent simulation of Single Flash Induced Transient Fluorescence Yield (SFITFY) traces that were earlier measured by Steffen et al. (2005) on whole leaves of Arabidopsis (A.) thaliana at four different energies of the actinic flash. As the essential modification, the shape of the actinic flash was explicitly taken into account assuming that an exponentially decaying rate simulates the time dependent excitation of PS II by the 10 ns actinic flash. The maximum amplitude of this excitation exceeds that of the measuring light by 9 orders of magnitude. A very good fit of the SFITFY data was achieved in the time domain from 100 ns to 10s for all actinic flash energies (the maximum energy of 7.5 × 10¹⁶ photons/(cm²flash) is set to 100%, the relative energies of weaker actinic flashes were of ∼8%, 4%, ∼1%). Our model allows the calculation and visualization of the transient PS II redox state populations ranging from the dark adapted state, via excitation energy and electron transfer steps induced by pulse excitation, followed by final relaxation into the stationary state eventually attained under the measuring light. It turned out that the rate constants of electron transfer steps are invariant to intensity of the actinic laser flash. In marked contrast, an increase of the actinic flash energy by more than two orders of magnitude from 5.4×10¹⁴ photons/(cm²flash) to 7.5×10¹⁶ photons/(cm²flash), leads to an increase of the extent of fluorescence quenching due to carotenoid triplet (³Car) formation by a factor of 14 and of the recombination reaction between reduced primary pheophytin (Phe(-)) and P680(+) by a factor of 3 while the heat dissipation in the antenna complex remains virtually constant. The modified PS II model offers new opportunities to compare electron transfer and dissipative parameters for different species (e.g. for the green algae and the

  11. A cII-dependent promoter is located within the Q gene of bacteriophage lambda.

    OpenAIRE

    Hoopes, B C; McClure, W R

    1985-01-01

    We have found a cII-dependent promoter, PaQ, within the Q gene of bacteriophage lambda. Transcription experiments and abortive initiation assays performed in vitro showed that the promoter strength and the cII affinity of PaQ were comparable to the other cII-dependent lambda promoters, PE and PI. The location and leftward direction of PaQ suggests a possible role in the delay of lambda late-gene expression by cII protein, a phenomenon that has been called cII-dependent inhibition. We have con...

  12. Overlapping Residual Herbicides for Control of Photosystem (PS) II- and 4-Hydroxyphenylpyruvate Dioxygenase (HPPD)-Inhibitor-Resistant Palmer amaranth (Amaranthus palmeri S. Watson) in Glyphosate-Resistant Maize

    Science.gov (United States)

    Chahal, Parminder S.; Ganie, Zahoor A.; Jhala, Amit J.

    2018-01-01

    A Palmer amaranth (Amaranthus palmeri S. Watson) biotype has evolved resistance to photosystem (PS) II- (atrazine) and 4-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibiting herbicides (mesotrione, tembotrione, and topramezone) in maize seed production field in Nebraska, USA. The objectives of this study were to determine the effect of soil residual pre-emergence (PRE) herbicides followed by (fb) tank-mixture of residual and foliar active post-emergence (POST) herbicides on PS-II- and HPPD-inhibitor-resistant Palmer amaranth control, maize yield, and net economic returns. Field experiments were conducted in a grower's field infested with PS II- and HPPD-inhibitor-resistant Palmer amaranth near Shickley in Fillmore County, Nebraska, USA in 2015 and 2016. The contrast analysis suggested that saflufenacil plus dimethenamid-P or pyroxasulfone plus saflufenacil applied PRE provided 80–82% Palmer amaranth control compared to 65 and 39% control with saflufenacil and pyroxasulfone applied alone at 3 weeks after PRE (WAPRE), respectively. Among the PRE fb POST herbicide programs, 95–98% Palmer amaranth control was achieved with pyroxasulfone plus safluefenacil, or saflufenacil plus dimethenamid-P applied PRE, fb glyphosate plus topramezone plus dimethenamid-P plus atrazine, glyphosate plus diflufenzopyr plus dicamba plus pyroxasulfone, glyphosate plus diflufenzopyr plus pendimethalin, or glyphosate plus diflufenzopyr plus dicamba plus atrazine applied POST at 3 weeks after POST (WAPOST) through maize harvest. Based on contrast analysis, PRE fb POST programs provided 77–83% Palmer amaranth control at 3 WAPOST through maize harvest compared to 12–15% control with PRE-only and 66–84% control with POST-only programs. Similarly, PRE fb POST programs provided 99% biomass reduction at 6 WAPOST compared to PRE-only (28%) and POST-only (87%) programs. PRE fb POST programs provided higher maize yield (13,617 kg ha−1) and net return (US $1,724 ha−1) compared to the PRE

  13. Structural and optical properties of tin (II) sulfide thin films deposited using organophosphorus precursor (Ph3PS)

    Science.gov (United States)

    Assili, Kawther; Alouani, Khaled; Vilanova, Xavier

    2017-02-01

    Tin sulfide (SnS) thin films have been deposited onto glass substrates using triphenylphosphine sulfide (Ph3PS) as a sulfur precursor in a chemical vapor deposition reactor in a temperature range of 250 °C-400 °C. The influence of the sulphidisation temperature in the crystal structure, surface morphology, chemical composition and optical properties has been investigated. X-ray diffraction, energy dispersive analysis of x-rays, and Raman spectroscopy showed that pure SnS thin films have been successfully obtained at 250 °C. All the deposited films were polycrystalline and showed orthorhombic structure, with a preferential orientation according to the direction . The optical measurements showed that the films deposited exhibited a direct allowed transition and have a relatively high absorption coefficient. The presence of mixed tin sulfide phases granted by the variation of the sulphidisation temperature has affected the optical properties of the deposited films. The refractive index (n) and extinction coefficient (k), has low values compared to conventional semiconductor materials. The grown films can be considered as a good light absorbing material and a promising candidate for application in optoelectronic devices.

  14. THE Fe II EMISSION IN ACTIVE GALACTIC NUCLEI: EXCITATION MECHANISMS AND LOCATION OF THE EMITTING REGION

    International Nuclear Information System (INIS)

    Marinello, M.; Rodríguez-Ardila, A.; Garcia-Rissmann, A.; Sigut, T. A. A.; Pradhan, A. K.

    2016-01-01

    We present a study of Fe ii emission in the near-infrared region (NIR) for 25 active galactic nuclei (AGNs) to obtain information about the excitation mechanisms that power it and the location where it is formed. We employ an NIR Fe ii template derived in the literature and find that it successfully reproduces the observed Fe ii spectrum. The Fe ii bump at 9200 Å detected in all objects studied confirms that Lyα fluorescence is always present in AGNs. The correlation found between the flux of the 9200 Å bump, the 1 μm lines, and the optical Fe ii implies that Lyα fluorescence plays an important role in Fe ii production. We determined that at least 18% of the optical Fe ii is due to this process, while collisional excitation dominates the production of the observed Fe ii. The line profiles of Fe ii λ10502, O i λ11287, Ca ii λ8664, and Paβ were compared to gather information about the most likely location where they are emitted. We found that Fe ii, O i and Ca ii have similar widths and are, on average, 30% narrower than Paβ. Assuming that the clouds emitting the lines are virialized, we show that the Fe ii is emitted in a region twice as far from the central source than Paβ. The distance, though, strongly varies: from 8.5 light-days for NGC 4051 to 198.2 light-days for Mrk 509. Our results reinforce the importance of the Fe ii in the NIR to constrain critical parameters that drive its physics and the underlying AGN kinematics, as well as more accurate models aimed at reproducing this complex emission

  15. THE Fe II EMISSION IN ACTIVE GALACTIC NUCLEI: EXCITATION MECHANISMS AND LOCATION OF THE EMITTING REGION

    Energy Technology Data Exchange (ETDEWEB)

    Marinello, M. [Universidade Federal de Itajubá, Rua Doutor Pereira Cabral 1303, 37500-903, Itajubá, MG (Brazil); Rodríguez-Ardila, A.; Garcia-Rissmann, A. [Laboratório Nacional de Astrofísica, Rua Estados Unidos 154, Itajubá, MG, 37504-364 (Brazil); Sigut, T. A. A. [The University of Western Ontario, London, ON N6A 3K7 (Canada); Pradhan, A. K., E-mail: murilo.marinello@gmail.com [McPherson Laboratory, The Ohio State University, 140 W. 18th Ave., Columbus, OH 43210-1173 (United States)

    2016-04-01

    We present a study of Fe ii emission in the near-infrared region (NIR) for 25 active galactic nuclei (AGNs) to obtain information about the excitation mechanisms that power it and the location where it is formed. We employ an NIR Fe ii template derived in the literature and find that it successfully reproduces the observed Fe ii spectrum. The Fe ii bump at 9200 Å detected in all objects studied confirms that Lyα fluorescence is always present in AGNs. The correlation found between the flux of the 9200 Å bump, the 1 μm lines, and the optical Fe ii implies that Lyα fluorescence plays an important role in Fe ii production. We determined that at least 18% of the optical Fe ii is due to this process, while collisional excitation dominates the production of the observed Fe ii. The line profiles of Fe ii λ10502, O i λ11287, Ca ii λ8664, and Paβ were compared to gather information about the most likely location where they are emitted. We found that Fe ii, O i and Ca ii have similar widths and are, on average, 30% narrower than Paβ. Assuming that the clouds emitting the lines are virialized, we show that the Fe ii is emitted in a region twice as far from the central source than Paβ. The distance, though, strongly varies: from 8.5 light-days for NGC 4051 to 198.2 light-days for Mrk 509. Our results reinforce the importance of the Fe ii in the NIR to constrain critical parameters that drive its physics and the underlying AGN kinematics, as well as more accurate models aimed at reproducing this complex emission.

  16. The mechanism of anthracene interaction with photosynthetic apparatus: A study using intact cells, thylakoid membranes and PS II complexes isolated from Chlamydomonas reinhardtii

    International Nuclear Information System (INIS)

    Aksmann, Anna; Shutova, Tatiana; Samuelsson, Goeran; Tukaj, Zbigniew

    2011-01-01

    Intact cells of Chlamydomonas reinhardtii as well as isolated thylakoid membranes and photosystem II complexes were used to examine a possible mechanism of anthracene (ANT) interaction with the photosynthetic apparatus. Since ANT concentrations above 1 mM were required to significantly inhibit the rate of oxygen evolution in PS II membrane fragments it may indicate that the toxicant did not directly interact with this photosystem. On the other hand, stimulation of oxygen uptake by ANT-treated thylakoids suggested that ANT could either act as an artificial electron acceptor in the photosynthetic electron transport chain or function as an uncoupler. Electron transfer from excited chlorophyll to ANT is impossible due to the very low reduction potential of ANT and therefore we propose that toxic concentrations of ANT increase the thylakoid membrane permeability and thereby function as an uncoupler, enhancing electron transport in vitro. Hence, its unspecific interference with photosynthetic membranes in vitro suggests that the inhibitory effect observed on intact cell photosynthesis is caused by uncoupling of phosphorylation.

  17. A multicenter, phase II study of bortezomib (PS-341) in patients with unresectable or metastatic gastric and gastroesophageal junction adenocarcinoma.

    Science.gov (United States)

    Shah, Manish A; Power, Derek G; Kindler, Hedy L; Holen, Kyle D; Kemeny, Margaret M; Ilson, David H; Tang, Laura; Capanu, Marinela; Wright, John J; Kelsen, David P

    2011-12-01

    The transcription factor nuclear factor-kB (NFkB) is implicated in gastric cancer carcinogenesis and survival, and its inhibition by proteosome inhibition is associated with preclinical gastric cancer anti-tumor activity. We examined the single agent efficacy of bortezomib, a selective proteasome inhibitor, in gastric adenocarcinoma. We performed a phase II trial of bortezomib in patients with advanced gastric adenocarcinoma. Bortezomib 1.3 mg/m(2) was administered on days 1, 4, 8, and 11 every 21 days. The primary endpoint was objective response rate(RR); the null hypothesis was RR <1% versus the alternative ≥15%. One response in the first stage(15 patients) was required before proceeding with an additional 18 patients. If at least 2 or more responses out of 33 were observed, further study with bortezomib was warranted. Correlative studies evaluated pre-treatment tumor expression of NFkB, IkB, p53, p21, and cyclin D1. We enrolled 16 patients (15 evaluable for response) from four institutions. No patients demonstrated an objective response(95% CI, 0-22%); one patient achieved stable disease. Fourteen out of 16 patients experienced ≥ grade 2 toxicity. The most common toxicity was fatigue in six patients (n = 4 grade 2, n = 2 grade 3). Seven patients experienced neuropathy (n = 5 grade 1, and 1 each grade 2 and 3). Seven (60%) had high cytoplasmic staining for NFkB. Single agent bortezomib is inactive in metastatic gastric adenocarcinoma and should not be pursued. Future study of proteasome inhibition in gastric adenocarcinoma should be considered in combination with targeted inhibition of other non-overlapping oncogenic pathways as a potential rational approach.

  18. Multiobjective Optimization for Fixture Locating Layout of Sheet Metal Part Using SVR and NSGA-II

    Directory of Open Access Journals (Sweden)

    Yuan Yang

    2017-01-01

    Full Text Available Fixture plays a significant role in determining the sheet metal part (SMP spatial position and restraining its excessive deformation in many manufacturing operations. However, it is still a difficult task to design and optimize SMP fixture locating layout at present because there exist multiple conflicting objectives and excessive computational cost of finite element analysis (FEA during the optimization process. To this end, a new multiobjective optimization method for SMP fixture locating layout is proposed in this paper based on the support vector regression (SVR surrogate model and the elitist nondominated sorting genetic algorithm (NSGA-II. By using ABAQUS™ Python script interface, a parametric FEA model is established. And the fixture locating layout is treated as design variables, while the overall deformation and maximum deformation of SMP under external forces are as the multiple objective functions. First, a limited number of training and testing samples are generated by combining Latin hypercube design (LHD with FEA. Second, two SVR prediction models corresponding to the multiple objectives are established by learning from the limited training samples and are integrated as the multiobjective optimization surrogate model. Third, NSGA-II is applied to determine the Pareto optimal solutions of SMP fixture locating layout. Finally, a multiobjective optimization for fixture locating layout of an aircraft fuselage skin case is conducted to illustrate and verify the proposed method.

  19. Mutation of Gly195 of the ChlH subunit of Mg-chelatase reduces chlorophyll and further disrupts PS II assembly in a Ycf48-deficient strain of Synechocystis sp. PCC 6803

    Directory of Open Access Journals (Sweden)

    Tim Crawford

    2016-07-01

    Full Text Available Biogenesis of the photosystems in oxygenic phototrophs requires co-translational insertion of chlorophyll a. The first committed step of chlorophyll a biosynthesis is the insertion of a Mg2+ ion into the tetrapyrrole intermediate protoporphyrin IX, catalyzed by Mg-chelatase. We have identified a Synechocystis sp. PCC 6803 strain with a spontaneous mutation in chlH that results in a Gly195 to Glu substitution in a conserved region of the catalytic subunit of Mg-chelatase. Mutant strains containing the ChlH Gly195 to Glu mutation were generated using a two-step protocol that introduced the chlH gene into a putative neutral site in the chromosome prior to deletion of the native gene. The Gly195 to Glu mutation resulted in strains with decreased chlorophyll a. Deletion of the PS II assembly factor Ycf48 in a strain carrying the ChlH Gly195 to Glu mutation did not grow photoautotrophically. In addition, the ChlH-G195E:ΔYcf48 strain showed impaired PS II activity and decreased assembly of PS II centers in comparison to a ΔYcf48 strain. We suggest decreased chlorophyll in the ChlH-G195E mutant provides a background to screen for the role of assembly factors that are not essential under optimal growth conditions.

  20. Metatarsalgia located by synovitis and uncertainty of the articulation metatarsus-phalanges of the II toe

    International Nuclear Information System (INIS)

    Gerstner G, Juan Bernardo

    2002-01-01

    The synovitis and the uncertainty of the articulation metatarsus-phalanges (MP) of the II toe they are the causes more frequent of metatersalgia located in this articulation of the foot, frequently bad diagnosed and not well managed by the general orthopedist. The natural history understands stadiums so precocious as the synovitis without alteration of peri-articular structures, going by the frank uncertainty, and finishing with the angular deformities and the complete luxation of the articulation MP. The meticulous and directed interrogation, the physical exam specifies and the classification of the diagnostic they are the keys for the successful handling of the pathology. The surgical correction of this condition should always be associated to the correction of associate deformities as the hallux valgus and the fingers in claw

  1. Impact of gas puffing location on density control and plasma parameters in TJ-II

    International Nuclear Information System (INIS)

    Tabares, F.L.; Garcia-Cortes, I.; Estrada, T.; Tafalla, D.; Hidalgo, A.; Ferreira, J.A.; Pastor, I.; Herranz, J.; Ascasibar, E.

    2005-01-01

    Under pure Electron Cyclotron Resonance Heating (ECRH) conditions in TJ-II plasmas (P<300 kW, 53.2 GHz, 2nd harmonic X-mode, power density < 25 W/m''3), plasma start-up and good density control are obtained only by the proper combination of wall conditions and gas puffing characteristics. Such a control is particularly critical for the optimisation of the NBI power transfer to the target plasmas. The relatively low cut-off limit is easily reached due not only to the unfavourable wall/puffing-fuelling ratio but also due to the steep density profiles developed during the Enhanced Particle Confinement (EPC) modes. These modes are triggered by the gas puffing waveform, and they cannot be achieved for high iota magnetic configurations in TJ-II. Comparative experiments under metallic and boronised wall conditions have shown that the sensitivity of the EPC modes to the puffing rate is at least partially related to the energy balance at the plasma periphery under central heating scenarios. In this work, the impact of gas-fuelling location on the plasma parameters and density control is described. For that purpose, three different fuelling locations have been investigated; broad distribution from a side ports, localized injection from long tubes at different poloidal positions and highly localized injection through a movable limiter. Edge density and temperature profiles from a broad set of diagnostics (atomic beams, reflectometry, Thompson Scattering ECE, etc...) are analysed and compared. It has been found that preventing from transition to the EPC mode is achieved by using slow puffing rates, while neutral penetration into the plasma core can be enhanced for highly localized gas sources. Wall inventory, however, has been found to pl ay a dominant role in the fuelling of the plasma under most conditions. (author)

  2. Selecting optimum locations for co-located wave and wind energy farms. Part II: A case study

    International Nuclear Information System (INIS)

    Astariz, S.; Iglesias, G.

    2016-01-01

    Highlights: • The benefits of wave and wind combined systems relative to independent farms are analysed. • This purpose is carried out through a case study off the Danish coast. • The power production, power smoothing and shadow effect are analysed. • Hindcast and measured wave and wind data from 2005 to 2015 are used. • Third-generation models of winds and waves (WAsP and SWAN) are used. - Abstract: Combined energy systems present an opportunity to enhance the competitiveness of renewables and overcome other challenges of these novel renewables by realising the synergies between them. Among the different possibilities for combined systems, this work focuses on wave and wind co-located farms with the aim of assessing their benefits relative to standalone wind farms. To this end we estimate the energy production, investigate the power smoothing and shadow effect, and quantify the reduction in downtime achieved by the co-located farm through a case study off the Danish coast – a promising area for co-located farms based on the available resource and other considerations including technical constraints. The analysis is carried out based on hindcast data and observations extending from 2005 to 2015, and by means of state-of-the-art numerical models of the wind and wave fields – WAsP and SWAN, respectively. It is found that the energy yield per unit area with the combined wave-wind farm increases by 3.4% relative to a standalone wind farm, the downtime periods decrease by 58% and the power output variability reduces by 12.5%. Moreover, the capital and operational expenditures (CAPEX and OPEX, respectively) would also be significantly reduced thanks to the synergies realised through the combination of wind and wave power.

  3. Site Characterization of the Source Physics Experiment Phase II Location Using Seismic Reflection Data

    Science.gov (United States)

    Sexton, E. A.; Snelson, C. M.; Chipman, V.; Emer, D. F.; White, R. L.; Emmitt, R.; Wright, A. A.; Drellack, S.; Huckins-Gang, H.; Mercadante, J.; Floyd, M.; McGowin, C.; Cothrun, C.; Bonal, N.

    2013-12-01

    An objective of the Source Physics Experiment (SPE) is to identify low-yield nuclear explosions from a regional distance. Low-yield nuclear explosions can often be difficult to discriminate among the clutter of natural and man-made explosive events (e.g., earthquakes and mine blasts). The SPE is broken into three phases. Phase I has provided the first of the physics-based data to test the empirical models that have been used to discriminate nuclear events. The Phase I series of tests were placed within a highly fractured granite body. The evolution of the project has led to development of Phase II, to be placed within the opposite end member of geology, an alluvium environment, thereby increasing the database of waveforms to build upon in the discrimination models. Both the granite and alluvium sites have hosted nearby nuclear tests, which provide comparisons for the chemical test data. Phase III of the SPE is yet to be determined. For Phase II of the experiment, characterization of the location is required to develop the geologic/geophysical models for the execution of the experiment. Criteria for the location are alluvium thickness of approximately 170 m and a water table below 170 m; minimal fracturing would be ideal. A P-wave mini-vibroseis survey was conducted at a potential site in alluvium to map out the subsurface geology. The seismic reflection profile consisted of 168 geophone stations, spaced 5 m apart. The mini-vibe was a 7,000-lb peak-force source, starting 57.5 m off the north end of the profile and ending 57.5 m past the southern-most geophone. The length of the profile was 835 m. The source points were placed every 5 m, equally spaced between geophones to reduce clipping. The vibroseis sweep was from 20 Hz down to 180 Hz over 8 seconds, and four sweeps were stacked at each shot location. The shot gathers show high signal-to-noise ratios with clear first arrivals across the entire spread and the suggestion of some shallow reflectors. The data were

  4. PS Booster - Festive colloquium

    CERN Multimedia

    2012-01-01

    A festive colloquium will be held to celebrate the 40th anniversary of the PS Booster on Friday, 28 September at 2 p.m. in the CERN council chamber. The meeting will be open to everybody. Read more on the PS Booster in the CERN Bulletin and in the CERN Courier.

  5. Last PS magnet refurbished

    CERN Multimedia

    2009-01-01

    PS Magnet Refurbishment Programme Completed. The 51st and final refurbished magnet was transported to the PS on Tuesday 3 February. The repair and consolidation work on the PS started back in 2003 when two magnets and a busbar connection were found to be faulty during routine high-voltage tests. The cause of the fault was a combination of age and radiation on electrical insulation. After further investigation the decision was taken to overhaul half of the PS’s 100 magnets to reduce the risk of a similar fault. As from 20 February the PS ring will start a five-week test programme to be ready for operation at the end of March.

  6. Antigen processing of glycoconjugate vaccines; the polysaccharide portion of the pneumococcal CRM(197) conjugate vaccine co-localizes with MHC II on the antigen processing cell surface.

    Science.gov (United States)

    Lai, Zengzu; Schreiber, John R

    2009-05-21

    Pneumococcal (Pn) polysaccharides (PS) are T-independent (TI) antigens and do not induce immunological memory or antibodies in infants. Conjugation of PnPS to the carrier protein CRM(197) induces PS-specific antibody in infants, and memory similar to T-dependent (Td) antigens. Conjugates have improved immunogenicity via antigen processing and presentation of carrier protein with MHC II and recruitment of T cell help, but the fate of the PS attached to the carrier is unknown. To determine the location of the PS component of PnPS-CRM(197) in the APC, we separately labeled PS and protein and tracked their location. The PS of types 14-CRM(197) and 19F-CRM(197) was specifically labeled by Alexa Fluor 594 hydrazide (red). The CRM(197) was separately labeled red in a reaction that did not label PS. Labeled antigens were incubated with APC which were fixed, permeabilized and incubated with anti-MHC II antibody labeled green by Alexa Fluor 488, followed by confocal microscopy. Labeled CRM(197) was presented on APC surface and co-localized with MHC II (yellow). Labeled unconjugated 14 or 19F PS did not go to the APC surface, but PS labeled 14-CRM(197) and 19F-CRM(197) was internalized and co-localized with MHC II. Monoclonal antibody to type 14 PS bound to intracellular type 14 PS and PS-CRM(197). Brefeldin A and chloroquine blocked both CRM(197) and PS labeled 14-CRM(197) and 19F-CRM(197) from co-localizing with MHC II. These data suggest that the PS component of the CRM(197) glycoconjugate enters the endosome, travels with CRM(197) peptides to the APC surface and co-localizes with MHC II.

  7. PS Control Room

    CERN Multimedia

    CERN PhotoLab

    1963-01-01

    The good old PS Control Room, all manual. For each parameter, a knob or a button to control it; for each, a light or meter or oscilloscope to monitor it; carefully written pages serve as the data bank; phones and intercom for communication. D.Dekkers is at the microphone, M.Valvini sits in front.

  8. PS auxiliary magnet

    CERN Multimedia

    CERN PhotoLab

    1974-01-01

    Units of the PS auxiliary magnet system. The picture shows how the new dipoles, used for vertical and horizontal high-energy beam manipulation, are split for installation and removal so that it is not necessary to break the accelerator vacuum. On the right, adjacent to the sector valve and the windings of the main magnet, is an octupole of the set.

  9. Location, location, location

    NARCIS (Netherlands)

    Anderson, S.P.; Goeree, J.K.; Ramer, R.

    1997-01-01

    We analyze the canonical location-then-price duopoly game with general log- concave consumer densities. A unique pure-strategy equilibrium to the two-stage game exists if the density is not "too asymmetric" and not "too concave." These criteria are satisfied by many commonly used densities.

  10. Innovative Solid State Lighting Replacements for Industrial and Test Facility Locations, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed effort will develop a solid-state LED replacement lamp for rocket engine test stand lighting and more general hazardous-location lighting. The LED...

  11. The PS booster

    CERN Multimedia

    CERN PhotoLab

    1972-01-01

    The PS booster which accelerates protons from the linac at an energy of 50 MeV to an energy of 800 MeV before injecting them into the main magnet ring of the synchrotron. The booster consists of four superposed rings. In the photograph can be seen the input beam line from the linac and the output beam lines, where beams from the four booster levels have been combined into two beams before final recombination.

  12. 77 FR 43536 - Wireless E911 Phase II Location Accuracy Requirements

    Science.gov (United States)

    2012-07-25

    ... neutrality. Providers deploying new CMRS networks are free to use network-based location techniques, or to... definition of covered CMRS providers in Section 20.18 and deploying networks subsequent to the effective date of the Third Report and Order that are not an expansion or upgrade of an existing CMRS network, must...

  13. Optimal locations of piezoelectric patches for supersonic flutter control of honeycomb sandwich panels, using the NSGA-II method

    International Nuclear Information System (INIS)

    Nezami, M; Gholami, B

    2016-01-01

    The active flutter control of supersonic sandwich panels with regular honeycomb interlayers under impact load excitation is studied using piezoelectric patches. A non-dominated sorting-based multi-objective evolutionary algorithm, called non-dominated sorting genetic algorithm II (NSGA-II) is suggested to find the optimal locations for different numbers of piezoelectric actuator/sensor pairs. Quasi-steady first order supersonic piston theory is employed to define aerodynamic loading and the p-method is applied to find the flutter bounds. Hamilton’s principle in conjunction with the generalized Fourier expansions and Galerkin method are used to develop the dynamical model of the structural systems in the state-space domain. The classical Runge–Kutta time integration algorithm is then used to calculate the open-loop aeroelastic response of the system. The maximum flutter velocity and minimum voltage applied to actuators are calculated according to the optimal locations of piezoelectric patches obtained using the NSGA-II and then the proportional feedback is used to actively suppress the closed loop system response. Finally the control effects, using the two different controllers, are compared. (paper)

  14. At PS170 (APPLE)

    CERN Multimedia

    CERN PhotoLab

    1983-01-01

    APPLE stands for Antiproton-Proton to Pair of LEptons (an acronym of the ancestor experiment PAPLEP), the PS170 experiment setup at LEAR to study e+e-pair production in antiproton-proton annihilation by Padova-(CEN) Saclay- Torino Collaboration. It consisted of a liquid hydrogen target surrounded by several layers of proportional chambers in the vertical field of a C-magnet (this photo), a gas Cerenkov counter, wire chambers, hodoscopes, and an electromagnetic calorimeter (see photo 8302539X, 8302540X). See also photo 8301539X for the setup assembly at an early stage.

  15. Beyond iPS!

    Directory of Open Access Journals (Sweden)

    Editorial

    2012-01-01

    Full Text Available It’s undoubtedly a jubilant moment for scientists and clinicians working in the stem cell arena as Prof. Gurdon and Prof. Shinya Yamanaka have been chosen for the Nobel Prize in Physiology & Medicine this year. The mystery of cell biology is something unfathomable and probably the work of this duo as well as the other scientists, who have put their hands on in- vitro de-differentiation have opened our eyes to a new window or a new paradigm in cell biology. The iPS invention has brought a lot of hope in terms of potential direct benefits to treat several diseases, which have no definite options at the moment. But, we envisage that several spin-offs could come out of this invention and one very significant spin-off finding recently witnessed is the finding by Prof. Masaharu Seno and his team of researchers at the Okayama University, Japan (Chen L, et al. 2012, PLoS ONE 7(4:e33544.doi:10.1371/journal.pone.0033544. According to Prof. Seno, mouse iPS cells (miPS when cultured in the conditioned medium derived from cancer cell lines, differentiate into cancer stem cells (CSCs. While differentiating into CSCs, they do retain the potential to develop endothelial progenitor cells. Several questions arise here: 1.Are these miPS derived CSCs really pluripotent, even if the terminal differentiation destined to specific phenotypes? 2.Shouldn’t the Cancer Stem Cells be termed as cancer progenitor cells, as till date they are considered to be producing only cancer cells but not pluripotent to yield other types of normal tissues? The spin-offs could be infinite as the process of differentiation and de-differentiation happening due to trillions of signals and pathways, most still remaining not-so-well understood. A special mention should be made to Prof. Shinya Yamanaka as he has several sterling qualities to be a role-model for budding scientists. Apart from his passion for science, which made him shift his career from orthopedics to a cell biologist, his

  16. PS Booster Orbit Correction

    CERN Document Server

    Chanel, M; Rumolo, G; Tomás, R; CERN. Geneva. AB Department

    2008-01-01

    At the end of the 2007 run, orbit measurements were carried out in the 4 rings of the PS Booster (PSB) for different working points and beam energies. The aim of these measurements was to provide the necessary input data for a PSB realignment campaign during the 2007/2008 shutdown. Currently, only very few corrector magnets can be operated reliably in the PSB; therefore the orbit correction has to be achieved by displacing (horizontally and vertically) and/or tilting some of the defocusing quadrupoles (QDs). In this report we first describe the orbit measurements, followed by a detailed explanation of the orbit correction strategy. Results and conclusions are presented in the last section.

  17. PS proton source

    CERN Multimedia

    1959-01-01

    The first proton source used at CERN's Proton Synchrotron (PS) which started operation in 1959. This is CERN's oldest accelerator still functioning today (2018). It is part of the accelerator chain that supplies proton beams to the Large Hadron Collider. The source is a Thonemann type. In order to extract and accelerate the protons at high energy, a high frequency electrical field is used (140Mhz). The field is transmitted by a coil around a discharge tube in order to maintain the gas hydrogen in an ionised state. An electrical field pulse, in the order of 15kV, is then applied via an impulse transformer between anode and cathode of the discharge tube. The electrons and protons of the plasma formed in the ionised gas in the tube, are then separated. Currents in the order of 200mA during 100 microseconds have benn obtained with this type of source.

  18. Symmetry of dipositronium Ps2

    International Nuclear Information System (INIS)

    Schrader, D.M.

    2004-01-01

    We work out the complete symmetry and spin problem for diatomic positronium Ps 2 for the ground and singly excited states of zero orbital angular momentum. The general form of the wave function for each state is given, with due regard to charge conjugation parity. Annihilation rates are discussed, and correlations to dissociation products are deduced. We indicate how the approach is extensible to larger aggregates: i.e., PsPs n , n>2

  19. SPS and PS Experiments Committee

    CERN Multimedia

    CERN. Geneva

    2004-01-01

    OPEN SESSION: 09:00 Status report of NA58 / COMPASS: A. Magnon 09:40 Status report of PS212 / DIRAC: L. Tausher 10:10 PS212 / DIRAC Addendum: L. Nemenov CLOSED SESSION on Tuesday, 27 April 2004 after the open session, Main Building, 6th floor conference room

  20. Electron spin resonance and electron spin echo modulation studies of Cu(II) ions in the aluminosilicate chabazite: A comparison of Cu(II) cation location and adsorbate interaction with isostructural silicoaluminophosphate-34

    International Nuclear Information System (INIS)

    Zamadics, M.; Kevan, L.

    1992-01-01

    This study focuses on Cu(II) ions exchanged in the aluminosilicate zeolite chabazite. The various Cu(II) species formed after dehydration, rehydration, and exposure to adsorbates are characterized by electron spin resonance and electron spin echo modulation spectroscopies. These results are interpreted in terms of Cu(II) ion location and adsorbate interaction. The results of this study are compared to the results found earlier for SAPO-34, chabazite's structural analog from the silicoaluminophosphate group. In a hydrated sample of chabazite the Cu(II) ions are found to be in a near octahedral environment coordinated to three nonequivalent water molecules and three framework oxygens. The most probable location of the Cu(II) ion in a hydrated sample is above the plane of the six-membered ring slightly displaced into the ellipsoidal cavity. A somewhat similar location and coordination is found for Cu(II) ions in H-SAPO-34. A feature common to both CuH-chabazite and CuH-SAPO-34 is the generation of two distinct Cu(II) species upon dehydration. It is found that Cu(II) cations in chabazite interact with the various adsorbate molecules in a similar manner as Cu(II) cation in H-chabazite and three molecules of ethanol and three propanol molecules. Only the Cu(II) ions located in the hexagonal rings after dehydration were found to complex with ethylene. The differences observed in the interaction of the Cu(II) in with water, propanol, and ehtylene between SAPO-34 and chabazite can be related to the differing cation densities of these two materials. 32 refs., 7 figs., 21 tabs

  1. Asymmetric PS-block-(PS-co-PB)-block-PS block copolymers: morphology formation and deformation behaviour

    International Nuclear Information System (INIS)

    Adhikari, Rameshwar; Huy, Trinh An; Buschnakowski, Matthias; Michler, Goerg H; Knoll, Konrad

    2004-01-01

    Morphology formation and deformation behaviour of asymmetric styrene/butadiene triblock copolymers (total polystyrene (PS) content ∼70%) consisting of PS outer blocks held apart by a styrene-co-butadiene random copolymer block (PS-co-PB) each were investigated. The techniques used were differential scanning calorimetry, transmission electron microscopy, uniaxial tensile testing and Fourier-transform infrared spectroscopy. A significant shift of the phase behaviour relative to that of a neat symmetric triblock copolymer was observed, which can be attributed to the asymmetric architecture and the presence of PS-co-PB as a soft block. The mechanical properties and the microdeformation phenomena were mainly controlled by the nature of their solid-state morphology. Independent of morphology type, the soft phase was found to deform to a significantly higher degree of orientation when compared with the hard phase

  2. Position pickup of the PS Booster

    CERN Multimedia

    CERN PhotoLab

    1975-01-01

    The beam position around the 4 rings of the PS Booster (originally 800 MeV, now 1.4 GeV), is measured with electrostatic pickups (PU). They consist of a ceramic cylinder forming part of the vacuum chamber, and, in order to save space, they are located inside the multipole lenses. The inside of the ceramic is coated with a metallic layer, into which the form of the electrodes was cut by computer-controlled micro-sandblasting. Each PU has a pair of horizontal and a pair of vertical electrodes, as well as a separate intensity-sensing circular electrode.

  3. The effect of gingival wall location on the marginal seal of class ii restorations prepared with a flowable bulk-fill resin-based composite.

    Science.gov (United States)

    Segal, P; Candotto, V; Ben-Amar, A; Eger, M; Matalon, S; Lauritano, D; Ormianer, Z

    2018-01-01

    SureFil SDR is a flowable resin-based composite that allows a single incremental bulk placement. The marginal seal of SureFil SDR at the gingival margins of class II restorations located apical to the cemento-enamel-junction (CEJ) has not been adequately evaluated compared to those located occlusal to the CEJ. Forty class II cavities were prepared in human molars. The gingival margins of 20 preparations were located 0.5 mm occlusal to the CEJ, and the other 20 preparations were located 0.5 mm apical to the CEJ. The cavities surfaces were bonded with XenoV dental adhesive and filled with SDR in one bulk increment up to 4 mm, after which they were covered with CeramX. The teeth were subjected to thermo-and load-cycling, and their gingival margins were exposed to 0.5% basic-fuchsin solution. The specimens were sectioned mesio-distally and scored for microleakage. A Wilcoxon test for pairwise comparison was performed to determine significance. Dye penetration was observed in 30% of the 20 restorations with cavo-surface margins located occlusal to the CEJ and in 55% of the 20 restorations with cavo-surface margins located apical to the CEJ. The bulk-fill flowable resin base SureFil SDR with XenoV dental adhesive provided a better marginal seal in class II restorations with gingival margins above the CEJ compared to restorations with gingival margins below the CEJ. SDR should not be recommended for class II cavity preparations with gingival margins located below the CEJ.

  4. Beyond the Point Ps Approximation

    OpenAIRE

    Stepanov, Sergey V.; Zvezhinskiy, Dmitry S.; Byakov, Vsevolod M.

    2012-01-01

    In application to positron annihilation spectroscopy, Ps atom is considered not as a point particle, but as a finite size e+ e- pair localized in a bubble-state in a medium. Variation of the internal Coulombic e+ -e- attraction vs. the bubble radius is estimated.

  5. The PS Booster hits 40

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    Many accelerators’ "round" birthdays are being celebrated at CERN these days – the PS turned 50 in 2009, the SPS was 35 in 2011, and this year it's the turn of the PS Booster to mark its 40th anniversary. Originally designed to accelerate 1013 protons to 800 MeV, it has far exceeded its initial design performance over the years.   The PS Booster in the 1970s. Imagine the scene: a group of accelerator physicists staring expectantly at a monitor, when suddenly a shout of joy goes up as a signal flickers across the screen. Does that sound familiar? Well, turn the clock back 40 years (longer hair, wider trouser legs) and you have the situation at the PS Booster on 26 May 1972. On that day, beam was injected into the Booster for the first time. “It was a real buzz,” says Heribert Koziol, then Chairman of the Running-in Committee. “We were very happy – and also a little relieved – when the beam finally...

  6. The PS locomotive runs again

    CERN Multimedia

    2001-01-01

    Over forty years ago, the PS train entered service to steer the magnets of the accelerator into place... ... a service that was resumed last Tuesday. Left to right: Raymond Brown (CERN), Claude Tholomier (D.B.S.), Marcel Genolin (CERN), Gérard Saumade (D.B.S.), Ingo Ruehl (CERN), Olivier Carlier (D.B.S.), Patrick Poisot (D.B.S.), Christian Recour (D.B.S.). It is more than ten years since people at CERN heard the rumbling of the old PS train's steel wheels. Last Tuesday, the locomotive came back into service to be tested. It is nothing like the monstrous steel engines still running on conventional railways -just a small electric battery-driven vehicle employed on installing the magnets for the PS accelerator more than 40 years ago. To do so, it used the tracks that run round the accelerator. In fact, it is the grandfather of the LEP monorail. After PS was commissioned in 1959, the little train was used more and more rarely. This is because magnets never break down, or hardly ever! In fact, the loc...

  7. VizieR Online Data Catalog: RR Lyrae stars from the PS1 3π survey (Sesar+, 2017)

    Science.gov (United States)

    Sesar, B.; Hernitschek, N.; Mitrovic, S.; Ivezic, Z.; Rix, H.-W.; Cohen, J. G.; Bernard, E. J.; Grebel, E. K.; Martin, N. F.; Schlafly, E. F.; Burgett, W. S.; Draper, P. W.; Flewelling, H.; Kaiser, N.; Kudritzki, R. P.; Magnier, E. A.; Metcalfe, N.; Tonry, J. L.; Waters, C.

    2018-04-01

    Building on the work by Hernitschek+ (2016, J/ApJ/817/73), in this paper, we use the final PS1 data release (PV3) to significantly increase the completeness and purity of the PS1 sample of RR Lyrae stars. Pan-STARRS1 (PS1; Kaiser+ 2010, see II/349) is a wide-field optical/near-IR survey telescope system located at the Haleakala Observatory on the island of Maui in Hawai'i. The largest survey undertaken by the telescope, the PS1 3π survey (Chambers K.C. 2011, BAAS, 43, 113.01), has observed the entire sky north of decl. -30° in five filter bands, reaching 5σ single-epoch depths of about 22.0, 22.0, 21.9, 21.0, and 19.8mag in gP1, rP1, iP1, zP1, and yP1 bands, respectively. The uncertainty in photometric calibration of the survey is <~0.01mag, and the astrometric precision of single-epoch detections is 10mas. (4 data files).

  8. Magnetic Field Considerations for the Design and Location of a Diagnostic Neutral Beam Injector for the TJ-II Stellarator

    International Nuclear Information System (INIS)

    McCarthy, K. J.; Lopez Fraguas, A.; Balbin, R.

    2004-01-01

    A diagnostic neutral beam injection system is being developed for the TJ-II stellarator. The principal goal is to increase the signal-to-noise ratio and to provide spatial resolution along the plasma minor radius in Charge Exchange Recombination Spectroscopy and Neutral Particle Analysis diagnostics, while also opening up new opportunities for physics studies. After summarizing the compact diagnostic neutral beam injector system selected as well as the TJ-II vacuum vessel and coil geometry, we address the sensitivity of TJ-II magnetic configurations to the ferromagnetic materials that shield the ion source and neutralizer tubing of the neutral beam injection system using a popular approach in which the field is approximated via magnetic dipole moments, finally, the scientific and design trade-offs made to minimize the impact are discussed. (Author) 24 refs

  9. BanII dimorphic site located in the third intron of the human apolipoprotein AI (APOA1) gene

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, R T; Kresnak, M T; Frossard, P M

    1988-02-11

    A 0.7kb fragment generated by AvaII digestion of pBL13AI, a 0.965kb full-length human apolipoprotein AI cDNA was cloned into the EcoRI site of pBR322. The apoAI cDNA was isolated from a lambdagt10 human fetal liver cDNA library. BanII (GPuGCPyC) (International Biotechnologies, Inc.) identifies two invariant bands at 1122bp and 417bp, and a single two-allele polymorphism with bands at either 274bp or 452bp. The human apolipoprotein AI-CIII-AIV gene complex has been localized on the long arm of chromosome 11 by Southern blot analysis of human-chinese hamster cell hybrids. Co-dominant segregation has been observed in two families (13 individuals). The BanII restriction map was constructed from DNA sequence data of the human apoAI gene. The 452bp fragment is generated by the loss of a BanII dimorphic site in the third intron of the apoAI gene, between the 178bp and the 274bp fragments.

  10. Peruvian Maca (Lepidium peruvianum): (II) Phytochemical Profiles of Four Prime Maca Phenotypes Grown in Two Geographically-Distant Locations.

    Science.gov (United States)

    O Meissner, Henry; Mscisz, Alina; Piatkowska, Ewa; Baraniak, Marek; Mielcarek, Sebastian; Kedzia, Bogdan; Holderna-Kedzia, Elzbieta; Pisulewski, Pawel

    2016-03-01

    Peruvian Maca crops (Lepidium peruvianum), grown in two geographically-distant cultivation sites located at similar altitudes in the highlands of the Peruvian Andes (Junin at 4,200 m a.s.l. and Ancash 4,150 m a.s.l.), were used in the study. Four prime Maca phenotypes, distinguished by hypocotyl colours labelled as "Yellow", "Purple", "Red" and "Black" were selected to determine distribution in levels and corresponding ratios between individual Glucosinolates (Glucotropaeolin and m-methylglucotropaeolin) in an attempt to identify four Peruvian Maca phenotypes from analyses of powdered hypocotyls. There were highly significant differences (PMaca phenotypes harvested in two locations. The Junin crop represented a mostly "large" class (13.3 g) with "small" size hypocotyls (7.2 g), while a "small" class was predominant in Ancash (3.5 g). Powdered Yellow Maca showed significantly higher (PMaca being the least infected. Only minor, statistically-confirmed differences were detected in nutritive characteristics between the four Maca phenotypes grown in Junin, however highly significant differences (PMaca grown in Junin and Ancash. Irrespective of the cultivation location, Red phenotypes showed the highest content of Total Glucosinolates, followed by Black and Purple, with the Yellow phenotype showing consistently lower levels. Highly significant PMaca phenotypes grown in two locations, confirms an earlier assumption that sums of individual Glucosinolates, their ratios and profiles, may be feasible to explore in analytically identifying individual Maca phenotypes in pulverised marketed Maca products.

  11. Mechanics of the Compression Wood Response: II. On the Location, Action, and Distribution of Compression Wood Formation.

    Science.gov (United States)

    Archer, R R; Wilson, B F

    1973-04-01

    A new method for simulation of cross-sectional growth provided detailed information on the location of normal wood and compression wood increments in two tilted white pine (Pinus strobus L.) leaders. These data were combined with data on stiffness, slope, and curvature changes over a 16-week period to make the mechanical analysis. The location of compression wood changed from the under side to a flank side and then to the upper side of the leader as the geotropic stimulus decreased, owing to compression wood action. Its location shifted back to a flank side when the direction of movement of the leader reversed. A model for this action, based on elongation strains, was developed and predicted the observed curvature changes with elongation strains of 0.3 to 0.5%, or a maximal compressive stress of 60 to 300 kilograms per square centimeter. After tilting, new wood formation was distributed so as to maintain consistent strain levels along the leaders in bending under gravitational loads. The computed effective elastic moduli were about the same for the two leaders throughout the season.

  12. EDH 'Millionaire' in PS Division

    CERN Multimedia

    2001-01-01

    Christmas cheer! Left to right: Gerard Lobeau receives a bottle of Champagne from Derek Mathieson and Jurgen De Jonghe in recognition of EDH's millionth document. At 14:33 on Monday 3 December a technician in PS division, Gerard Lobeau, unwittingly became part of an important event in the life of CERN's Electronic Document Handling system (EDH). While ordering some pieces of aluminum for one of the PS's 10Mhz RF cavities, he created EDH document number 1,000,000. To celebrate the event Derek Mathieson (EDH Project Leader) and Jurgen De Jonghe (Original EDH Project Leader) presented Mr Lobeau with a bottle of champagne. As with 93% of material requests, Mr Lobeau's order was delivered within 24 hours. 'I usually never win anything' said Mr Lobeau as he accepted his prize, 'I initially though there may have been a problem with EDH when the document number had so many zeros in it, and was then surprised to get a phone call from you a few minutes later.' The EDH team had been monitoring the EDH document number ...

  13. A BAYESIAN APPROACH TO LOCATING THE RED GIANT BRANCH TIP MAGNITUDE. II. DISTANCES TO THE SATELLITES OF M31

    Energy Technology Data Exchange (ETDEWEB)

    Conn, A. R.; Parker, Q. A.; Zucker, D. B. [Department of Physics and Astronomy, Macquarie University, NSW 2109 (Australia); Ibata, R. A.; Martin, N. F. [Observatoire Astronomique, Universite de Strasbourg, CNRS, F-67000 Strasbourg (France); Lewis, G. F. [Sydney Institute for Astronomy, School of Physics, A28, University of Sydney, Sydney, NSW 2006 (Australia); McConnachie, A. W. [NRC Herzberg Institute of Astrophysics, 5071 West Saanich Road, Victoria, British Columbia V9E 2E7 (Canada); Irwin, M. J.; Chapman, S. C. [Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA (United Kingdom); Tanvir, N. [Department of Physics and Astronomy, University of Leicester, Leicester LE1 7RH (United Kingdom); Fardal, M. A. [University of Massachusetts, Department of Astronomy, LGRT 619-E, 710 N. Pleasant Street, Amherst, MA 01003-9305 (United States); Ferguson, A. M. N. [Institute for Astronomy, University of Edinburgh, Royal Observatory, Blackford Hill, Edinburgh EH9 3HJ (United Kingdom); Valls-Gabaud, D. [Observatoire de Paris, LERMA, 61 Avenue de l' Observatoire, F-75014 Paris (France)

    2012-10-10

    In 'A Bayesian Approach to Locating the Red Giant Branch Tip Magnitude (Part I)', a new technique was introduced for obtaining distances using the tip of the red giant branch (TRGB) standard candle. Here we describe a useful complement to the technique with the potential to further reduce the uncertainty in our distance measurements by incorporating a matched-filter weighting scheme into the model likelihood calculations. In this scheme, stars are weighted according to their probability of being true object members. We then re-test our modified algorithm using random-realization artificial data to verify the validity of the generated posterior probability distributions (PPDs) and proceed to apply the algorithm to the satellite system of M31, culminating in a three-dimensional view of the system. Further to the distributions thus obtained, we apply a satellite-specific prior on the satellite distances to weight the resulting distance posterior distributions, based on the halo density profile. Thus in a single publication, using a single method, a comprehensive coverage of the distances to the companion galaxies of M31 is presented, encompassing the dwarf spheroidals Andromedas I-III, V, IX-XXVII, and XXX along with NGC 147, NGC 185, M33, and M31 itself. Of these, the distances to Andromedas XXIV-XXVII and Andromeda XXX have never before been derived using the TRGB. Object distances are determined from high-resolution tip magnitude posterior distributions generated using the Markov Chain Monte Carlo technique and associated sampling of these distributions to take into account uncertainties in foreground extinction and the absolute magnitude of the TRGB as well as photometric errors. The distance PPDs obtained for each object both with and without the aforementioned prior are made available to the reader in tabular form. The large object coverage takes advantage of the unprecedented size and photometric depth of the Pan-Andromeda Archaeological Survey

  14. Human hair follicle pluripotent stem (hfPS) cells promote regeneration of peripheral-nerve injury: an advantageous alternative to ES and iPS cells.

    Science.gov (United States)

    Amoh, Yasuyuki; Kanoh, Maho; Niiyama, Shiro; Hamada, Yuko; Kawahara, Katsumasa; Sato, Yuichi; Hoffman, Robert M; Katsuoka, Kensei

    2009-08-01

    The optimal source of stem cells for regenerative medicine is a major question. Embryonic stem (ES) cells have shown promise for pluripotency but have ethical issues and potential to form teratomas. Pluripotent stem cells have been produced from skin cells by either viral-, plasmid- or transposon-mediated gene transfer. These stem cells have been termed induced pluripotent stem cells or iPS cells. iPS cells may also have malignant potential and are inefficiently produced. Embryonic stem cells may not be suited for individualized therapy, since they can undergo immunologic rejection. To address these fundamental problems, our group is developing hair follicle pluripotent stem (hfPS) cells. Our previous studies have shown that mouse hfPS cells can differentiate to neurons, glial cells in vitro, and other cell types, and can promote nerve and spinal cord regeneration in vivo. hfPS cells are located above the hair follicle bulge in what we have termed the hfPS cell area (hfPSA) and are nestin positive and keratin 15 (K-15) negative. Human hfPS cells can also differentiate into neurons, glia, keratinocytes, smooth muscle cells, and melanocytes in vitro. In the present study, human hfPS cells were transplanted in the severed sciatic nerve of the mouse where they differentiated into glial fibrillary-acidic-protein (GFAP)-positive Schwann cells and promoted the recovery of pre-existing axons, leading to nerve generation. The regenerated nerve recovered function and, upon electrical stimulation, contracted the gastrocnemius muscle. The hfPS cells can be readily isolated from the human scalp, thereby providing an accessible, autologous and safe source of stem cells for regenerative medicine that have important advantages over ES or iPS cells. (c) 2009 Wiley-Liss, Inc.

  15. The LLL compact 10-ps streak camera

    International Nuclear Information System (INIS)

    Thomas, S.W.; Houghton, J.W.; Tripp, G.R.; Coleman, L.W.

    1975-01-01

    The 10-ps streak camera has been redesigned to simplify its operation, reduce manufacturing costs, and improve its appearance. The electronics have been simplified, a film indexer added, and a contacted slit has been evaluated. Data support a 10-ps resolution. (author)

  16. Enhanced personal protection at the PS

    CERN Multimedia

    Samuel Morier Genoud

    2013-01-01

    Pictures 03, 06, 07 08 : Pierre Ninin, deputy group leader of GS-ASE and responsible for the installation of the new PS complex safety system, in front of a new access control system.Pictures 10, 12 ,13 : View of Building 271, the future control centre of the new PS complex safety system.

  17. PS, SL and LHC Auditoria change names

    CERN Multimedia

    2003-01-01

    Following the replacement of the PS, SL and LHC Divisions by the AB and AT Divisions, the Auditoria are also changing their names. PS Auditorium is renamed AB Meyrin SL Auditorium is renamed AB Prévessin LHC Auditorium is renamed AT

  18. Theoretical considerations regarding the existence of PsO and PsS+

    International Nuclear Information System (INIS)

    Farazdel, A.; Cade, P.E.

    1977-01-01

    It has been proposed from experimental studies and in analogy with hydrogen compounds that PsO may be an entity of some importance, or an intermediate, in the reaction of positronium, Ps, with aqueous oxyacid species such as H 2 PO 4 - , HSO 4 - , ClO 4 - , and NO 3 - . This communication explores the stability of PsO and PsS, or [O - :e + ] and [S - :e + ], respectively, relative to dissociation into Ps and O( 3 P) or S( 3 P) on the basis of restricted Hartree-Fock calculations for the PsO and PsS systems and certain correlation correction arguments. A reasonable lower estimate of the dissociation energy to Y+Ps of >-0.47 eV for PsO and >0.70 eV for PsS is obtained. It is suggested that a modest correlation correction to the positron affinity (PA) of O - would very probably lead to a bound state system for PsO. (Auth.)

  19. A Location Privacy Aware Friend Locator

    DEFF Research Database (Denmark)

    Siksnys, Laurynas; Thomsen, Jeppe Rishede; Saltenis, Simonas

    2009-01-01

    to trade their location privacy for quality of service, limiting the attractiveness of the services. The challenge is to develop a communication-efficient solution such that (i) it detects proximity between a user and the user’s friends, (ii) any other party is not allowed to infer the location of the user...

  20. On the crystallization behavior of syndiotactic-b-atactic polystyrene stereodiblock copolymers, atactic/syndiotactic polystyrene blends, and aPS/sPS blends modified with sPS-b-aPS

    Energy Technology Data Exchange (ETDEWEB)

    Annunziata, Liana, E-mail: liana.annunziatta@univ-rennes1.fr [Organométalliques et Catalyse, UMR 6226 Sciences Chimiques CNRS, Université de Rennes 1, Campus de Beaulieu, F-35042 Rennes Cedex (France); Monasse, Bernard, E-mail: bernard.monasse@mines-paristech.fr [Mines-ParisTech, CEMEF, Centre de Mise en Forme des Matériaux, UMR CNRS 7635, Sophia Antipolis (France); Rizzo, Paola; Guerra, Gaetano [Dipartimento di Chimica e Biologia, Università degli studi di Salerno, Via Ponte don Melillo, I-84084 Fisciano, SA (Italy); Duc, Michel [Total Petrochemicals Research Feluy, Zone Industrielle Feluy C, B-7181 Seneffe (Belgium); Carpentier, Jean-François, E-mail: jean-francois.carpentier@univ-rennes1.fr [Organométalliques et Catalyse, UMR 6226 Sciences Chimiques CNRS, Université de Rennes 1, Campus de Beaulieu, F-35042 Rennes Cedex (France)

    2013-09-16

    Crystallization and morphological features of syndiotactic-b-atactic polystyrene stereodiblock copolymers (sPS-b-aPS), atactic/syndiotactic polystyrene blends (aPS/sPS), and aPS/sPS blends modified with sPS-b-aPS, with different compositions in aPS and sPS, have been investigated using differential scanning calorimetry (DSC), polarized light optical microscopy (POM) and wide angle X-ray diffraction (WAXRD) techniques. For comparative purposes, the properties of parent pristine sPS samples were also studied. WAXRD analyses revealed for all the samples, independently from their composition (aPS/sPS ratio) and structure (blends, block copolymers, blends modified with block copolymers), the same polymorphic β form of sPS. The molecular weight of aPS and sPS showed opposite effects on the crystallization of 50:50 aPS/sPS blends: the lower the molecular weight of aPS, the slower the crystallization while the lower the molecular weight of sPS, the faster the crystallization. DSC studies performed under both isothermal and non-isothermal conditions, independently confirmed by POM studies, led to a clear trend for the crystallization rate at a given sPS/aPS ratio (ca. 50:50 and 20:80): sPS homopolymers > sPS-b-aPS block copolymers ∼sPS/aPS blends modified with sPS-b-aPS copolymers > sPS/aPS blends. Interestingly, sPS-b-aPS block copolymers not only crystallized faster than blends, but also affected positively the crystallization behavior of blends. At 50:50 sPS/aPS ratio, blends (Blend-2), block copolymers (Cop-1) and blends modified with block copolymers (Blend-2-mod) crystallized via spherulitic crystalline growth controlled by an interfacial process. In all cases, an instantaneous nucleation was observed. The density of nuclei in block copolymers (160,000−190,000 nuclei mm{sup −3}) was always higher than that in blends and modified blends (30,000−60,000 nuclei mm{sup −3}), even for quite different sPS/aPS ratio. At 20:80 sPS/aPS ratio, the block copolymers

  1. Syntheses of polystyrene supported chelating resin containing the Schiff base derived from salicylaldehyde and triethylene tetramine and its copper(II), nickel(II), cobalt(II), iron(III), zinc(II), cadmium(II), molybdenum(VI), zirconium(IV) and uranium(VI) complexes

    International Nuclear Information System (INIS)

    Syamal, A.; Singh, M.M.

    1998-01-01

    A new polymer-anchored chelating ligand has been synthesized by the reaction of chloromethylated polystyrene (containing 0.94 mmol of Cl per gram of resin and 1% cross-linked with divinylbenzene) and the Schiff base derived from salicylaldehyde and triethylenetetramine. A new series of polystyrene supported, Cu(II), Ni(II), Co(II), Fe(III), Zn(II), Cd(II), Zr(IV), dioxomolybdenum (VI) and dioxouranium (VI) complexes of the formulae PS-LCu, PS-LNi, PS-LCo, PS-LFeCl.DMF, PS-LZn, PS-LCd, PS-LZr(OH) 2 . DMF, PS L MoO 2 and PS-LUO 2 (where PS-LH 2 = polymer-anchored Schiff base and DMF dimethyl-formamide) have been synthesized and characterised by elemental analysis, infrared, electronic spectra and magnetic susceptibility measurements. The complexes PS-LCu, PS-LNi and PS-LCo have square planar structure, PS-LFeCl.DMF, PS-LMoO 2 and PS-LUO 2 have octahedral structure, PS L Zn and PS-LCd are tetrahedral and PS-LZr(OH) 2 .DMF is pentagonal bipyramidal. The polymer-anchored Cu(II), Co(II) and Fe(III) complexes are paramagnetic while Ni(II), Zn(II), Cd(II), Zr(IV), dioxomolybdenum(VI) and dioxouranium(VI) complexes are diamagnetic. The negative shift of the v (C=N) (azomethine) and the positive shift of v (C--O)(phenolic) are indicative of ONNO donor behaviour of the polymer-anchored Schiff base. (author)

  2. Synthesis of NiPS3 and CoPS and its hydrogen storage capacity

    International Nuclear Information System (INIS)

    Ismail, N.; Madian, M.; El-Meligi, A.A.

    2014-01-01

    Highlights: • Preparation of NiPS 3 and CoPS using solid state reaction. • Characterization of compounds using XRD, TEM, SEM and IR. • Measuring the compounds thermal stability. • Estimation of the hydrogen storage capacity. -- Abstract: Prepared CoPS and NiPS 3 are studied as new materials for hydrogen energy storage. Single phase of CoPS and NiPS 3 were grown separately in evacuated silicatube via solid state reaction at 650 °C with controlled heating rate 1 °C/min. X-ray diffraction patterns confirm the formation of the desired compounds. Both CoPS and NiPS 3 exhibited high thermal stability up to 700 °C and 630 °C, respectively. The morphology of the prepared samples was investigated using scanning electron microscopy and folded sheets appeared in the transmission electron microscopy. The samples were exposed to 20 bar applied hydrogen pressure at 80 K. Both compounds appear to have feasible hydrogen storage capacity. CoPS was capable to adsorb 1.7 wt% while NiPS 3 storage capacity reached 1.2 wt%

  3. Gamma Transition Jump for PS2

    CERN Document Server

    Bartmann, W; Métral, E; Möhl, D; Peggs, S

    2008-01-01

    The PS2, which is proposed as a replacement for the existing ~50-year old PS accelerator, is presently considered to be a normal conducting synchrotron with an injection kinetic energy of 4 GeV and a maximum energy of 50 GeV. One of the possible lattices (FODO option) foresees crossing of transition energy near 10 GeV. Since the phase-slip-factor $\\eta$ becomes very small near transition energy, many intensity dependent effects can take place in both longitudinal and transverse planes. The aim of the present paper is on the one hand to scale the gamma transition jump, used since 1973 in the PS, to the projected PS2 and on the other hand based on these results the analysis of the implementation and feasibility of a gamma transition jump scheme in a conventional FODO lattice.

  4. Ps 22 in Gospels’ interpretation of Passion

    Directory of Open Access Journals (Sweden)

    Sylwester Jędrzejewski

    2012-09-01

    Full Text Available Ps 22 is a piece of artistically high poetry, clear images and metaphors, historical and prophetic references. The conviction of biblical scholars that the New Testament writers has recognized in Ps 22 prophetic witness of passion, accompanies the Church from its beginnings. The words of Jesus on the cross, taken from Ps 22: 2, have a character of lamentable re-symbolization of the prayer of Israel. These words establish a theological answer in the form of suitable credo as well. Dramatic question “why?” is connected with a proclamation and identification “My God”. The personal experience of oppression and death is included by Jesus in the history of his nation and in the experience of God. Ps 22 in the Gospels’ passion context becomes a proclamation form of prayer and a very personal, expressed in such dramatic circumstances confession of the faith.

  5. PS overcomes two serious magnet failures

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. Here we see the PS magnet string awaiting the replacement no. 6 magnet.

  6. The coat protein complex II, COPII, protein Sec13 directly interacts with presenilin-1

    International Nuclear Information System (INIS)

    Nielsen, Anders Lade

    2009-01-01

    Mutations in the human gene encoding presenilin-1, PS1, account for most cases of early-onset familial Alzheimer's disease. PS1 has nine transmembrane domains and a large loop orientated towards the cytoplasm. PS1 locates to cellular compartments as endoplasmic reticulum (ER), Golgi apparatus, vesicular structures, and plasma membrane, and is an integral member of γ-secretase, a protein protease complex with specificity for intra-membranous cleavage of substrates such as β-amyloid precursor protein. Here, an interaction between PS1 and the Sec13 protein is described. Sec13 takes part in coat protein complex II, COPII, vesicular trafficking, nuclear pore function, and ER directed protein sequestering and degradation control. The interaction maps to the N-terminal part of the large hydrophilic PS1 loop and the first of the six WD40-repeats present in Sec13. The identified Sec13 interaction to PS1 is a new candidate interaction for linking PS1 to secretory and protein degrading vesicular circuits.

  7. The coat protein complex II, COPII, protein Sec13 directly interacts with presenilin-1

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Anders Lade, E-mail: aln@humgen.au.dk [Department of Human Genetics, The Bartholin Building, University of Aarhus, DK-8000 Aarhus C (Denmark)

    2009-10-23

    Mutations in the human gene encoding presenilin-1, PS1, account for most cases of early-onset familial Alzheimer's disease. PS1 has nine transmembrane domains and a large loop orientated towards the cytoplasm. PS1 locates to cellular compartments as endoplasmic reticulum (ER), Golgi apparatus, vesicular structures, and plasma membrane, and is an integral member of {gamma}-secretase, a protein protease complex with specificity for intra-membranous cleavage of substrates such as {beta}-amyloid precursor protein. Here, an interaction between PS1 and the Sec13 protein is described. Sec13 takes part in coat protein complex II, COPII, vesicular trafficking, nuclear pore function, and ER directed protein sequestering and degradation control. The interaction maps to the N-terminal part of the large hydrophilic PS1 loop and the first of the six WD40-repeats present in Sec13. The identified Sec13 interaction to PS1 is a new candidate interaction for linking PS1 to secretory and protein degrading vesicular circuits.

  8. Photosystem II electron flow as a measure for phytoplankton gross primary production = [Fotosysteem II elektronentransport als een maat voor de bruto primaire produktie van fytoplankton

    NARCIS (Netherlands)

    Geel, C.

    1997-01-01

    Saturating pulse fluorescence measurements, well known from studies of higher plants for determination of photosystem II (PS II) characteristics, were applied to cultures of the green alga Dunaliella teitiolecta (Chapter 2). The actual efficiency of PS IIPS

  9. LS1 Report: PS beams are back!

    CERN Multimedia

    Katarina Anthony & Anaïs Schaeffer

    2014-01-01

    For the first time in over 15 months, there are beams back in the PS. Making their first tour of the accelerator today, 20 June, their injection marks the end of weeks of cold checkouts and hardware commissioning in the PS.   The CERN Control Centre (CCC) is back in business: people gather to restart the LHC injectors, today the PS. Since hardware commissioning was wrapped up on 23 May, the Operations Group (BE-OP) has been conducting cold checkouts on the PS. This involves switching on all of the machine's systems, verifying that they respond to commands by OP and ensuring they are calibrated to beam timings. "These verifications were done, in part, during the hardware commissioning dry runs," says Rende Steerenberg, PS section leader. "But the cold checkouts are on a much larger scale, as we act as if there is beam in the whole machine. We placed a full load on the controls system, cooling, networks, etc. in order to setup the accelerator in the most realis...

  10. 100-ps framing-camera tube

    International Nuclear Information System (INIS)

    Kalibjian, R.

    1978-01-01

    The optoelectronic framing-camera tube described is capable of recording two-dimensional image frames with high spatial resolution in the <100-ps range. Framing is performed by streaking a two-dimensional electron image across narrow slits. The resulting dissected electron line images from the slits are restored into framed images by a restorer deflector operating synchronously with the dissector deflector. The number of framed images on the tube's viewing screen equals the number of dissecting slits in the tube. Performance has been demonstrated in a prototype tube by recording 135-ps-duration framed images of 2.5-mm patterns at the cathode. The limitation in the framing speed is in the external drivers for the deflectors and not in the tube design characteristics. Faster frame speeds in the <100-ps range can be obtained by use of faster deflection drivers

  11. PS Main Control Room (partial view)

    CERN Multimedia

    1974-01-01

    Jean-Pierre Potier (turning buttons) and Bertran Frammery (telephoning) on shift. The 26 GeV Synchrotron and later also its related machines (Linacs 1,2,3; PS-Booster; LEP-Injector Linacs and Electron-Positron Accumulator; Antiproton Accumulator, Antiproton Collector, Low Energy Antiproton Ring and more recently Antiproton Decelerator) were all controlled from the PS control room situated on the Meyrin site. The SPS and LEP were controlled from a separat control centre on the Prevessin site. In 2005 all controls were transferred to the Prevessin centre.

  12. PS overcomes two serious magnet failures

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. These pictures show one of the magnets (no. 19) on the PS locomotive brought back into service for the removal and replacement operations.

  13. Back to work for the PS

    CERN Multimedia

    2006-01-01

    On 22 June, the PS's rotating machine started turning again for the first time since its enforced shutdown one month ago (see Bulletin No. 23-24/2006) - and the PS was back in operation the very next day! A team from Siemens worked their socks off, 6 days a week for one month (including public holidays), to repair the electrical power supply in collaboration with the AB/PO Group's Main Power Converters (MPC) Section. The generator's faulty rotor was dismantled and replaced by the renovated spare rotor. The multitude of electrical and mechanical connections together with the sheer weight of the rotor (80 tonnes) made this an extremely complex job. The AB/PO Group used the shutdown to test a back-up solution for the PS power supply. The accelerator was directly wired up to the 18 kV electrical network via a 13 MVA transformer, installed at the end of the 1970s but never used. This solution succeeded in bringing the PS back into operation but at limited energy and frequency. Just 14 GeV could be achieved, whic...

  14. CNA-motion in a PS - Fn

    International Nuclear Information System (INIS)

    Singh, M.P.; Mishra, C.K.

    1989-12-01

    A Finsler space Fn (n > 2), throughout with the projective curvature tensor possessing vanishing covariant derivative, has been called a ''projectively symmetric Finsler space'' and such a space is denoted PS-Fn. The conditions in which an infinitesimal transformation defines non-affine motion with a contra-field, briefly called CNA-motion, are discussed. 7 refs

  15. Beyond metric gravity: Progress on PS-200

    International Nuclear Information System (INIS)

    Goldman, T.; Brown, R.E.; Camp, J.B.; Darling, T.; Dyer, P.; Holzscheiter, M.H.; Hughes, R.J.; Jarmie, N.; King, N.S.P.; Lizon, D.C.; Nieto, M.M.; Schauer, M.M.M.; Schecker, J.A.; Cornford, S.; Hosea, K.; Kenefick, R.A.; Hoibraaten, S.; Midzor, M.M.; Parry, S.P.; Ristenen, R.A.; Witteborn, F.C.

    1993-01-01

    The reconciliation of quantum mechanics and gravity on varying distance scales requires changes to General Relativity that may be testable implications. We briefly review the status of tests with matter of the inverse square law and the principle of equivalence, then report on progress on the drift-tube measurement section of PS- 200, the experiment to measure the gravitational acceleration of antiprotons

  16. NIKHEF: AmPS of electron beam

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    Now operational at the Dutch National Institute for Nuclear Physics and High Energy Physics (NIKHEF), Amsterdam, is a new tool for studying the electromagnetic properties of nuclei. Called AmPS - Amsterdam pulse stretcher - this ring provides experiments with a smoother, almost continuous supply of electrons

  17. ps-ro Fuzzy Open(Closed Functions and ps-ro Fuzzy Semi-Homeomorphism

    Directory of Open Access Journals (Sweden)

    Pankaj Chettri

    2015-11-01

    Full Text Available The aim of this paper is to introduce and characterize some new class of functions in a fuzzy topological space termed as ps-ro fuzzy open(closed functions, ps-ro fuzzy pre semiopen functions and ps-ro fuzzy semi-homeomorphism. The interrelation among these concepts and also their relations with the parallel existing concepts are established. It is also shown with the help of examples that these newly introduced concepts are independent of the well known existing allied concepts.

  18. PS overcomes two serious magnet failures

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Two magnets (no.'s 6 and 19)and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. Pictured here are members of the PS team with the replacement no. 6 magnet. From left to right: In the back row, Frédéric Roussel (Transport DBS), Yves Bernard (Transport DBS), Luc Moreno (Cegelec), Thierry Battimanza (Transport DBS), Raymond Brown (AB/ABP), Thomas Zickler (AT/MEL); at the front, Steven Southern (AT/VAC), Thierry Gaidon (Brun & Sorensen), Philippe Vidales (Cegelec), Daniel Aubert (Cegelec), Jerome Cachet (Transport DBS), Jose Manual Gomes de Faria (AT/MEL), Eric Page (AT/VAC).

  19. Motor-Generator Set, PS Main Supply

    CERN Multimedia

    CERN PhotoLab

    1983-01-01

    This is the "new" motor-generator set. It replaced the previous, original, one which had served from the PS start-up in 1959. Ordered in 1965, installed in 1967, it was brought into operation at the beginning of 1968. Regularly serviced and fitted with modern regulation and controls, it still serves at the time of writing (2006) and promises to serve for several more years, as a very much alive museum-piece. See also 6803016 and 0201010.

  20. PS overcomes two serious magnet failures

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators´ spring start-up to two weeks. Here we see one of the replacement magnets (no. 19) being prepared.

  1. PS overcomes two serious magnet failures

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. Here we see one of the replacement magnets (no. 6) being prepared.

  2. The PS overcomes two serious magnet failures

    CERN Multimedia

    2003-01-01

    Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks.

  3. Measuring target for the PS Booster

    CERN Multimedia

    1971-01-01

    The measuring target for the PS Booster (originally 800 MeV, now 1.4 GeV). It measures the size of the beam by destroying all particles with amplitudes greater than the size of the fork, the position and width of which are adjustable. The plunging time is only 20 ms and the acceleration at the tip of the fork reaches 90 g. The servo-controlled linear motor is shown detached from the mechanism. See also 7602008.

  4. Successful online learning the five Ps

    OpenAIRE

    Jim FLOOD

    2004-01-01

    Successful online learning the five Ps Jim FLOOD E-learning Consultant-UK Key learning points An important aspect of design for online learning is visual ergonomics. Learning theories offer poor predictive power in terms of how learners work and learn. Success at learning is closely related to emotional engagementand learning designers tend to ignore this aspect. Online learning poses a challenging experience for learnersand they need support t...

  5. Enhanced personal protection system for the PS

    CERN Multimedia

    Caroline Duc

    2013-01-01

    During the first long shutdown (LS1) a new safety system will be installed in the primary beam areas of the PS complex in order to bring the standard of personnel radiation protection at the PS into line with that of the LHC.   Pierre Ninin, deputy group leader of GS-ASE and responsible for the installation of the new PS complex safety system, in front of a new access control system. The LHC access control systems are state-of-the-art, whereas those of the injection chain accelerators were running the risk of becoming obsolete. For the past two years a project to upgrade the access and safety systems of the first links in the LHC accelerator chain has been underway to bring them into compliance with nuclear safety standards. These systems provide the personnel with automatic protection by limiting access to hazardous areas and by ensuring that nobody is present in the areas when the accelerator is in operation. By the end of 2013, the project teams will ha...

  6. Locative media

    CERN Document Server

    Wilken, Rowan

    2014-01-01

    Not only is locative media one of the fastest growing areas in digital technology, but questions of location and location-awareness are increasingly central to our contemporary engagements with online and mobile media, and indeed media and culture generally. This volume is a comprehensive account of the various location-based technologies, services, applications, and cultures, as media, with an aim to identify, inventory, explore, and critique their cultural, economic, political, social, and policy dimensions internationally. In particular, the collection is organized around the perception that the growth of locative media gives rise to a number of crucial questions concerning the areas of culture, economy, and policy.

  7. Expectation values of the e+PsH system

    International Nuclear Information System (INIS)

    Zhang, J.-Y.; Mitroy, J.

    2007-01-01

    Close to converged energies and expectation values for e + PsH are computed using a ground-state wave function consisting of 1500 explicitly correlated Gaussians. The best estimate of the e + PsH ∞ energy was -0.810 254 hartrees, which has a binding energy of 0.021 057 hartrees against dissociation into e + +PsH. The 2γ annihilation rate was 2.7508x10 9 s -1 . Binding energies and annihilation rates are also given for the different finite-mass variants of e + PsH. Comparisons between expectation values for e + PsH and PsH provide compelling evidence that the e + PsH ground state can be regarded as consisting of a weakly bound positron orbiting the PsH ground state

  8. Location, location, location: Extracting location value from house prices

    OpenAIRE

    Kolbe, Jens; Schulz, Rainer; Wersing, Martin; Werwatz, Axel

    2012-01-01

    The price for a single-family house depends both on the characteristics of the building and on its location. We propose a novel semiparametric method to extract location values from house prices. After splitting house prices into building and land components, location values are estimated with adaptive weight smoothing. The adaptive estimator requires neither strong smoothness assumptions nor local symmetry. We apply the method to house transactions from Berlin, Germany. The estimated surface...

  9. PACE. A Program for Acquiring Competence in Entrepreneurship. Part II: Becoming an Entrepreneur. Unit B: Where to Locate the Business. Research and Development Series No. 194 B-2.

    Science.gov (United States)

    Ohio State Univ., Columbus. National Center for Research in Vocational Education.

    This three-part curriculum for entrepreneurship education is primarily for postsecondary level, including four-year colleges and adult education, but it can be adapted for special groups or vocational teacher education. The emphasis of the seven instructional units in Part II is on establishing a business. Unit B focuses on choosing a business…

  10. Chemotherapy and quality of life in NSCLC PS 2 patients

    DEFF Research Database (Denmark)

    Helbekkmo, Nina; Strøm, Hans H; Sundstrøm, Stein H

    2009-01-01

    , fatigue, dyspnea, sleeping problems and appetite loss in comparison to the PS 0/1 group. CONCLUSIONS: PS 2 NSCLC patients seem to achieve valuable HRQOL benefits from platinum-based combination therapy. Prospective clinical studies with predefined HRQOL outcomes in PS 2 patients are needed to confirm...

  11. Psühhodramaatikud annavad Pärnus eksami

    Index Scriptorium Estoniae

    2008-01-01

    29. maist kuni 1. juunini kestab Pärnus psühhodraama konverents "Geeniuste kohtumine", kus rahvusvahelise koolituse läbinud annavad eksami. Ruuda Palmquist on psühhodraama kui teadusharu rajajaid Eestis. Pärnus on kohal Rootsi Moreno Instituudi juhataja, psühhodraama lavastaja Marc Treadwell

  12. Bluish-green BMes2-functionalized Pt(II) complexes for high efficiency PhOLEDs: impact of the BMes2 location on emission color.

    Science.gov (United States)

    Rao, Ying-Li; Schoenmakers, Dylan; Chang, Yi-Lu; Lu, Jia-Sheng; Lu, Zheng-Hong; Kang, Youngjin; Wang, Suning

    2012-09-03

    New phosphorescent Pt(II) compounds based on dimesitylboron (BMes(2))-functionalized 2-phenylpyridyl (ppy) N,C-chelate ligands and an acetylacetonato ancillary ligand have been achieved. We have found that BMes(2) substitution at the 4'-position of the phenyl ring can blue-shift the phosphorescent emission energy of the Pt(II) compound by approximately 50 nm, compared to the 5'-BMes(2) substituted analogue, without substantial loss of luminescent quantum efficiencies. The emission color of the 4'-BMes(2) substituted Pt(II) compound, Pt(Bppy)(acac) (1) can be further tuned by the introduction of a substituent group at the 3'-position of the phenyl ring. A methyl substituent red-shifts the emission energy of 1 by approximately 10 nm whereas a fluoro substituent blue-shifts the emission energy by about 6 nm. Using this strategy, three bright blue-green phosphorescent Pt(II) compounds 1, 2 and 3 with emission energy at 481, 492, and 475 nm and Φ(PL)=0.43, 0.26 and 0.25, respectively, have been achieved. In addition, we have examined the impact of BMes(2) substitution on 3,5-dipyridylbenzene (dpb) N,C,N-chelate Pt(II) compounds by synthesizing compound 4, Pt(Bdpb)Cl, which has a BMes(2) group at the 4'-position of the benzene ring. Compound 4 has a phosphorescent emission band at 485 nm and Φ(PL)=0.70. Highly efficient blue-green electroluminescent (EL) devices with a double-layer structure and compounds 1, 3 or 4 as the phosphorescent dopant have been fabricated. At 100 cd m(-2) luminance, EL devices based on 1, 3 and 4 with an external quantum efficiency of 4.7, 6.5 and 13.4%, respectively, have been achieved. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Improvement of Data Acquisition of the BRTR (PS-43) Seismic Array

    Science.gov (United States)

    Ozel, N. M.; Kocak, S.; Semin, K. U.; Necmioglu, O.; Destici, T. C.; Teoman, U.

    2010-05-01

    Bogazici University, Kandilli Observatory and Earthquake Research Institute(KOERI) is currently operating the BRTR( PS-43) seismic arrays located in the vicinity of Ankara and town Keskin, providing real-time data to IDC. PS-43 is composed of two sub-arrays, the medium-period array with a ~45km radius located in Ankara and the short-period array with ~3 km radius located in Keskin. In 2009, data availabilty of the BRTR is exceeded %98 that value is the requirment of IDC. Substantial contribution to obtain this availabiliy is implementing the improvements that mainly replacement of the grid type parabolic antennas with the heavy-duty dish antennas at necessary sites called the repeater sites RE-BRTR (CCF), RE-PS43 (Mt. Elmadag), CF-PS43 (Central Recording Building) and all MP sites. Even this renewed system is at the tentative stage, communication status of the seismic arrays are solid and continuous. BRTR is expecting another improvement, June 2010, about the power system at Mt. Elmadag and the MP site BR237. Completion of this improvement will be stabilize of our current mission.

  14. Characterizing Lithospheric Thickness in Australia using Ps and Sp Scattered Waves

    Science.gov (United States)

    Ford, H. A.; Fischer, K. M.; Rychert, C. A.

    2008-12-01

    The purpose of this study is to constrain the morphology of the lithosphere-asthenosphere boundary throughout Australia using scattered waves. Prior surface wave studies have shown a correlation between lithospheric thickness and the three primary geologic provinces of Australia, with the shallowest lithosphere located beneath the Phanerozoic province to the east, and the thicker lithosphere located beneath the Proterozoic and Archean regions. To determine lithospheric thickness, waveform data from twenty permanent broadband stations spanning mainland Australia and the island of Tasmania were analyzed using Ps and Sp migration techniques. Waveform selection for each station was based on epicentral distance (35° to 80° for Ps and 55° to 80° for Sp), and event depth (no greater than 300 km for Sp). For both Ps and Sp a simultaneous deconvolution was performed on the data for each of the twenty stations, and the resulting receiver function for each station was migrated to depth. Data were binned with epicentral distance to differentiate direct discontinuity phases from crustal reverberations (for Ps) and other teleseismic arrivals (for Sp). Early results in both Ps and Sp show a clear Moho discontinuity at most stations in addition to sharp, strong crustal reverberations seen in many of the Ps images. In the eastern Phanerozoic province, a strong negative phase at 100-105 km is evident in Ps for stations CAN and EIDS. The negative phase lies within a depth range that corresponds to the negative velocity gradient between fast lithosphere and slow asthenosphere imaged by surface waves. We therefore think that it is the lithosphere- asthenosphere boundary. On the island of Tasmania, a negative phase at 70-75 km in Ps images at stations TAU and MOO also appears to be the lithosphere-asthenosphere boundary. In the Proterozoic and Archean regions of the Australian continent, initial results for both Ps and Sp migration indicate clear crustal phases, but significantly

  15. Space charge studies in the PS

    CERN Document Server

    Asvesta, F; Damerau, H; Huschauer, A; Papaphilippou, Y; Serluca, M; Sterbini, G; Zisopoulos, P

    2017-01-01

    In this paper the results of Machine Development (MD)studies conducted at the CERN Proton Sychrotron (PS) arepresented. The main focus was the investigation of newworking points in an effort to characterize and potentiallyimprove the brightness for LHC-type beams in view of theLHC Injectors Upgrade (LIU). Various working points werecompared in terms of losses and emittance evolution. Sincespace charge and the resonances it excites are the main causefor emittance blow-up and losses, tunes close to excitedresonances were carefully studied. Mitigation techniques,such as bunch flattening using a double harmonic RF system,were also tested.

  16. Electron Spin Resonance studies on PS, PP and PS/PP blends under gamma irradiation

    International Nuclear Information System (INIS)

    Reyes, J.; Claro, M.; Albano, C.; Venezuela Central University, Caracas; Moronta, D.

    2002-01-01

    Complete text of publication follows. Electron Spin Resonance (ESR) studies on Polystyrene (PS), Polypropylene (PP) and their mixtures at compositions of 80/20 with and without a compatibilizer (SBS in block), 7.5 wt.%, irradiated with gamma rays from a Cobalt-60 source with a dose rate of 4.8 KGy/h at integral doses of radiation of 10, 25, 50, 60, 70, 400, 800 and 1300 KGy in the presence of air and at room temperature (RT) are reported. The dependence of resonance line width, Hpp; resonance line shapes K, and radical concentration, S, with the integral dose of irradiation is investigated. The nature of the free radicals after ten days of air storage is discussed. The free radical concentration, the double integral of the resonance line, S, has been estimated at room temperature, RT, for a group of single lines, characterized by the same giromagnetic, g, value by direct numerical double integration. In the samples studied no spectrum of 0 kGy of integral dose was observed. The concentration of radicals, S, observed when the integral radiation doses was increased, presents a maximum value in the PP samples at high doses (70-1300 kGy) and minimum values in the PS samples with the same doses. This shows that the PP degrades at a faster rate than the PS, owing to the presence of the bencenic ring in the latter. In the PS/PP mixtures studied with and without compatibilizer, the values of the radical concentration is found between the observed values in the homopolymers, being closer to the PS, which might imply that the presence of PS decays the degradation process of the PP in the mixture

  17. Sofrimento psíquico e trabalho

    Directory of Open Access Journals (Sweden)

    Sarah Rosa Salles Vieira

    2014-03-01

    Full Text Available O presente artigo aprofunda questões clínico-téoricas relacionadas especificamente ao trabalho docente e ao sofrimento psíquico a ele relacionado a partir da observação clínica e vivência grupal nos atendimentos terapêuticos ocupacionais realizados no Hospital do Servidor Público Estadual de São Paulo "Francisco Morato de Oliveira" (HSPE-FMO. Partindo dos estudos acerca da Psicopatologia do Trabalho de Christophe Dejours, do trabalho docente e do relato de um caso clínico, caracteriza a problemática do sofrimento no trabalho, os sistemas de defesa contra este sofrimento, a ameaça à subjetividade do próprio trabalhador, as representações e conflitos vivenciados no trabalho docente, bem como a relação aditiva estabelecida como uma estratégia inconsciente de sobrevivência psíquica.

  18. Library Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Carnegie Library of Pittsburgh locations including address, coordinates, phone number, square footage, and standard operating hours. The map below does not display...

  19. Comparison of molecular species of various transphosphatidylated phosphatidylserine (PS) with bovine cortex PS by mass spectrometry

    NARCIS (Netherlands)

    Chen, S.; Li, K.W.

    2008-01-01

    The exogenous introduction of a molecular species mixture of bovine cortex phosphatidylserine (BC-PS) has been claimed to improve memory function in subjects suffering from age-associated memory impairment and dementia. However, it has been also reported that oral administration of another molecular

  20. Electronic apex locator: A comprehensive literature review — Part II: Effect of different clinical and technical conditions on electronic apex locator′s accuracy

    Directory of Open Access Journals (Sweden)

    Hamid Razavian

    2014-01-01

    Full Text Available Introduction: To investigate the effects of different clinical and technical conditions on the accuracy of electronic apex locators (EALs. Materials and Methods: "Tooth apex," "dental instrument," "odontometry," "electronic medical," and "electronic apex locator" were searched as primary identifiers via Medline/PubMed, Cochrane library, and Scopus data base up to 30 July 2013. Original articles that fulfilled the inclusion criteria were selected and reviewed. Results: Out of 402 relevant studies, 183 were selected based on the inclusion criteria. In this part, 75 studies are presented. Pulp vitality conditions and root resorption, types of files and irrigating materials do not affect an EAL′s accuracy; however, the file size and foramen diameter can affect its accuracy. Conclusions: Various clinical conditions such as the file size and foramen diameter may affect EALs′ accuracy. However, more randomized clinical trials are needed for definitive conclusion.

  1. Determination of grafting conversion degree in PS/PS-graft-POSS/POSS hybrid nanocomposites obtained through reactive processing

    International Nuclear Information System (INIS)

    Bianchi, Otavio; Repenning, Gustavo B.; Mauler, Raquel S.; Oliveira, Ricardo V.B.; Canto, Leonardo B.

    2011-01-01

    Hybrid nanocomposites of polystyrene (PS) and polyhedral oligomeric silsesquioxanes (POSS) - PS/PS-graft-POSS/POSS - with different grafting degrees were prepared by reactive melt processing using dicumyl peroxide (DCP) as initiator in the presence or absence of styrene monomer as radical transfer agent. Gel permeation chromatography (GPC) using triple-detector and proton nuclear magnetic resonance (NMR 1 H) analyses were used together to determine the conversion degree of PS-graft-POSS as a function of the reactive processing conditions adopted. GPC was employed to evaluate the effects of grafting (PS-graft-POSS) and PS chains degradation (β scission) that occur simultaneously during processing on the variation of average molecular masses and distributions for each PS/POSS sample. PS/POSS systems processed with styrene showed higher weight average molecular weights (M w ) and lower polydispersity indexes (M w /M n ), as a result of higher grafting (PS-graft-POSS) conversion (28-40%) and lower PS chain degradation level, as compared to PS/POSS systems processed without styrene in which the degree of grafting conversion was around 25-28%. (author)

  2. Sequence control of phase separation and dewetting in PS/PVME blend thin films by changing molecular weight of PS.

    Science.gov (United States)

    Xia, Tian; Qin, Yaping; Huang, Yajiang; Huang, Ting; Xu, Jianhui; Li, Youbing

    2016-11-28

    The morphology evolution mechanism of polystyrene (PS)/poly (vinyl methyl ether) (PVME) blend thin films with different PS molecular weights (M w ) was studied. It was found that the morphology evolution was closely related to the molecular weight asymmetry between PS and PVME. In the film where M w (PS) ≈ M w (PVME), dewetting happened at the interface between the bottom layer and substrate after SD phase separation. While in the film where M w (PS) > M w (PVME), dewetting happened at the interface between the middle PS/PVME blend layer and bottom PVME layer near the substrate prior to phase separation. The different sequences of phase separation and dewetting and different interface for dewetting occurrence were studied by regarding the competitive effects of viscoelasticity contrast between polymer components and preferential wetting between PVME and the substrate. The viscoelastic nature of the PS component played a crucial role in the sequence of phase separation and dewetting.

  3. PS2004 Light-harvesting Systems Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Blankenship, Robert E.

    2005-01-01

    This special issue of the international scientific research journal Photosynthesis Research consists of 25 original peer-reviewed contributions from participants in the PS 2004 Lisht-Harvesting Systems Workshop. This workshop was held from 26-29, 2004 at Hotel Le Chantecler, Sainte-Adele, Quebec, Canada. The workshop was a satellite meeting of the XIII International Congress on Photosynthesis held August 29-September 3, 2004 in Montreal, Canada. The workshope dealt with all types of photosynthetic antenna systems and types of organisms, including anoxygenic photosynthetic bacteria, cyanobacteria, algae and higher plants, as well as in vitro studies of isolated pigments. This collection of papers is a good representation of the highly interdisciplinary nature of modern research on photosynthetic antenna complexes, utilizing techniques of advanced spectroscopy, biochemistry, molecular biology, synthetic chemistry and structural determination to understand these diverse and elegant molecular complexes.

  4. PS main supply: motor-generator set.

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    In picture 04 the motor is on the right in the background and the main view is of the generator. The peak power in each PS cycle drawn from the generator, up to 96 MW, is taken from the rotational kinetic energy of the rotor (a heavy-weight of 80 tons), which makes the rotational speed drop by only a few percent. The motor replenishes the average power of 2 to 4 MW. Photo 05: The motor-generator set is serviced every year and, in particular, bearings and slip-rings are carefully checked. To the left is the motor with its slip-rings visible. It has been detached from the axle and moved to the side, so that the rotor can be removed from the huge generator, looming at the right.

  5. Gene Locater

    DEFF Research Database (Denmark)

    Anwar, Muhammad Zohaib; Sehar, Anoosha; Rehman, Inayat-Ur

    2012-01-01

    software's for calculating recombination frequency is mostly limited to the range and flexibility of this type of analysis. GENE LOCATER is a fully customizable program for calculating recombination frequency, written in JAVA. Through an easy-to-use interface, GENE LOCATOR allows users a high degree...... of flexibility in calculating genetic linkage and displaying linkage group. Among other features, this software enables user to identify linkage groups with output visualized graphically. The program calculates interference and coefficient of coincidence with elevated accuracy in sample datasets. AVAILABILITY...

  6. Location of 3-hydroxyproline residues in collagen types I, II, III, and V/XI implies a role in fibril supramolecular assembly.

    Science.gov (United States)

    Weis, Mary Ann; Hudson, David M; Kim, Lammy; Scott, Melissa; Wu, Jiann-Jiu; Eyre, David R

    2010-01-22

    Collagen triple helices are stabilized by 4-hydroxyproline residues. No function is known for the much less common 3-hydroxyproline (3Hyp), although genetic defects inhibiting its formation cause recessive osteogenesis imperfecta. To help understand the pathogenesis, we used mass spectrometry to identify the sites and local sequence motifs of 3Hyp residues in fibril-forming collagens from normal human and bovine tissues. The results confirm a single, essentially fully occupied 3Hyp site (A1) at Pro(986) in A-clade chains alpha1(I), alpha1(II), and alpha2(V). Two partially modified sites (A2 and A3) were found at Pro(944) in alpha1(II) and alpha2(V) and Pro(707) in alpha2(I) and alpha2(V), which differed from A1 in sequence motif. Significantly, the distance between sites 2 and 3, 237 residues, is close to the collagen D-period (234 residues). A search for additional D-periodic 3Hyp sites revealed a fourth site (A4) at Pro(470) in alpha2(V), 237 residues N-terminal to site 3. In contrast, human and bovine type III collagen contained no 3Hyp at any site, despite a candidate proline residue and recognizable A1 sequence motif. A conserved histidine in mammalian alpha1(III) at A1 may have prevented 3-hydroxylation because this site in chicken type III was fully hydroxylated, and tyrosine replaced histidine. All three B-clade type V/XI collagen chains revealed the same three sites of 3Hyp but at different loci and sequence contexts from those in A-clade collagen chains. Two of these B-clade sites were spaced apart by 231 residues. From these and other observations we propose a fundamental role for 3Hyp residues in the ordered self-assembly of collagen supramolecular structures.

  7. Molecular features of colorectal polyps presenting Kudo’s type II mucosal crypt pattern: are they based on the same mechanism of tumorigenesis?

    Science.gov (United States)

    Shinmura, Kensuke; Konishi, Kazuo; Yamochi, Toshiko; Kubota, Yutaro; Yano, Yuichiro; Katagiri, Atsushi; Muramoto, Takashi; Kihara, Toshihiro; Tojo, Masayuki; Konda, Kenichi; Tagawa, Teppei; Yanagisawa, Fumito; Kogo, Mari; Makino, Reiko; Takimoto, Masafumi; Yoshida, Hitoshi

    2014-01-01

    Background and study aims: The molecular features of serrated polyps (SPs) with hyperplastic crypt pattern, also called Kudo’s type II observed by chromoendoscopy, were evaluated. Methods: The clinicopathological and molecular features of 114 SPs with a hyperplastic pit pattern detected under chromoendoscopy (five dysplastic SPs, 63 sessile serrated adenoma/polyps (SSA/Ps), 36 microvesicular hyperplastic polyps (MVHPs), and 10 goblet cell-rich hyperplastic polyps (GCHPs)) were examined. The frequency of KRAS and BRAF mutations and CpG island methylator phenotype (CIMP) were investigated. Results: Dysplastic SPs and SSA/Ps were frequently located in the proximal colon compared to others (SSA/Ps vs. MVHPs or GCHPs, P GCHP (60 % for dysplastic SPs, 44 % for SSA/Ps, 47 % for MVHPs, and 0 % for GCHPs). The frequency of CIMP was higher in dysplastic SPs or SSA/Ps than in MVHPs or GCHPs (60 % for dysplastic SPs, 56 % for SSA/Ps, 32 % for MVHPs, and 10 % for GCHPs) (SSA/Ps vs. GCHP, P = 0.0068). When serrated neoplasias (SNs) and MVHPs were classified into proximal and distal lesions, the frequency of CIMP was significantly higher in the proximal compared to the distal SNs (64 % vs. 11 %, P = 0.0032). Finally, multivariate analysis showed that proximal location and BRAF mutation were significantly associated with an increased risk of CIMP. Conclusions: Distinct molecular features were observed between proximal and distal SPs with hyperplastic crypt pattern. Proximal MVHPs may develop more frequently through SSA/Ps to CIMP cancers than distal MVHPs. PMID:26134964

  8. Molecular features of colorectal polyps presenting Kudo's type II mucosal crypt pattern: are they based on the same mechanism of tumorigenesis?

    Science.gov (United States)

    Shinmura, Kensuke; Konishi, Kazuo; Yamochi, Toshiko; Kubota, Yutaro; Yano, Yuichiro; Katagiri, Atsushi; Muramoto, Takashi; Kihara, Toshihiro; Tojo, Masayuki; Konda, Kenichi; Tagawa, Teppei; Yanagisawa, Fumito; Kogo, Mari; Makino, Reiko; Takimoto, Masafumi; Yoshida, Hitoshi

    2014-09-01

    The molecular features of serrated polyps (SPs) with hyperplastic crypt pattern, also called Kudo's type II observed by chromoendoscopy, were evaluated. The clinicopathological and molecular features of 114 SPs with a hyperplastic pit pattern detected under chromoendoscopy (five dysplastic SPs, 63 sessile serrated adenoma/polyps (SSA/Ps), 36 microvesicular hyperplastic polyps (MVHPs), and 10 goblet cell-rich hyperplastic polyps (GCHPs)) were examined. The frequency of KRAS and BRAF mutations and CpG island methylator phenotype (CIMP) were investigated. Dysplastic SPs and SSA/Ps were frequently located in the proximal colon compared to others (SSA/Ps vs. MVHPs or GCHPs, P GCHP (60 % for dysplastic SPs, 44 % for SSA/Ps, 47 % for MVHPs, and 0 % for GCHPs). The frequency of CIMP was higher in dysplastic SPs or SSA/Ps than in MVHPs or GCHPs (60 % for dysplastic SPs, 56 % for SSA/Ps, 32 % for MVHPs, and 10 % for GCHPs) (SSA/Ps vs. GCHP, P = 0.0068). When serrated neoplasias (SNs) and MVHPs were classified into proximal and distal lesions, the frequency of CIMP was significantly higher in the proximal compared to the distal SNs (64 % vs. 11 %, P = 0.0032). Finally, multivariate analysis showed that proximal location and BRAF mutation were significantly associated with an increased risk of CIMP. Distinct molecular features were observed between proximal and distal SPs with hyperplastic crypt pattern. Proximal MVHPs may develop more frequently through SSA/Ps to CIMP cancers than distal MVHPs.

  9. Spatio-temporal responses of Arabidopsis leaves in photosynthetic performance and metabolite contents to Burkholderia phytofirmans PsJN

    Directory of Open Access Journals (Sweden)

    Fan eSu

    2016-03-01

    Full Text Available A valuable strategy to improve crop yield consists in the use of plant growth-promoting rhizobacteria (PGPRs. However, the influence of PGPR colonization on plant physiology is largely unknown. PGPR Burkholderia phytofirmans strain PsJN (Bp PsJN colonized only Arabidopsis thaliana roots after seed or soil inoculation. Foliar bacteria were detected only after leaf infiltration. Since different bacterial times of presence and/or locations in host plant could lead to different plant physiological responses, photosynthesis and metabolite profiles in A. thaliana leaves were thus investigated following leaf, root or seed inoculation with Bp PsJN. Only Bp PsJN leaf colonization transiently decreased cyclic electron transport and effective quantum yield of photosystem I (PSI, and prevented a decrease in net photosynthesis and stomatal opening compared to the corresponding control. Metabolomic analysis revealed that soluble sugars, amino acids or their derivatives accumulated differently in all Bp PsJN-inoculated plants. Octanoic acid accumulated only in case of inoculated plants. Modifications in vitamin, organic acid such as tricarboxylic acid intermediates, and hormone amounts were dependent on bacterial time of presence and location. Additionally, a larger array of amino acids and hormones (auxin, cytokinin, abscisic acid were modified by seed inoculation with Bp PsJN. Our work thereby provides evidence that relative short-term inoculation with Bp PsJN altered physiological status of A.thaliana leaves, whereas long-term bacterization triggered modifications on a larger set of metabolites. Our data highlighted the changes displayed during this plant-microbe interaction to trigger physiological and metabolic responses that could explain the increase in plant growth or stress tolerance conferred by the presence of Bp PsJN.

  10. psRNATarget: a plant small RNA target analysis server (2017 release).

    Science.gov (United States)

    Dai, Xinbin; Zhuang, Zhaohong; Zhao, Patrick Xuechun

    2018-04-30

    Plant regulatory small RNAs (sRNAs), which include most microRNAs (miRNAs) and a subset of small interfering RNAs (siRNAs), such as the phased siRNAs (phasiRNAs), play important roles in regulating gene expression. Although generated from genetically distinct biogenesis pathways, these regulatory sRNAs share the same mechanisms for post-translational gene silencing and translational inhibition. psRNATarget was developed to identify plant sRNA targets by (i) analyzing complementary matching between the sRNA sequence and target mRNA sequence using a predefined scoring schema and (ii) by evaluating target site accessibility. This update enhances its analytical performance by developing a new scoring schema that is capable of discovering miRNA-mRNA interactions at higher 'recall rates' without significantly increasing total prediction output. The scoring procedure is customizable for the users to search both canonical and non-canonical targets. This update also enables transmitting and analyzing 'big' data empowered by (a) the implementation of multi-threading chunked file uploading, which can be paused and resumed, using HTML5 APIs and (b) the allocation of significantly more computing nodes to its back-end Linux cluster. The updated psRNATarget server has clear, compelling and user-friendly interfaces that enhance user experiences and present data clearly and concisely. The psRNATarget is freely available at http://plantgrn.noble.org/psRNATarget/.

  11. Energy and expectation values of the PsH system

    International Nuclear Information System (INIS)

    Mitroy, J.

    2006-01-01

    Close to converged energies and expectation values for PsH are computed using a ground state wave function consisting of 1800 explicitly correlated gaussians. The best estimate of the Ps ∞ H energy was -0.789 196 740 hartree which is the lowest variational energy to date. The 2γ annihilation rate for Ps ∞ H was 2.471 78x10 9 s -1

  12. The PrPS4 type structure and a filled variant: the compounds TbPS4 and LiEuPS4

    International Nuclear Information System (INIS)

    Joergens, S.; Alili, L.; Mewis, A.

    2005-01-01

    Colourless single crystals of TbPS 4 (a = 10.696(2), c = 19.053(4) Aa) were obtained by reaction of the elements (750 C; 30 h). The compound crystallizes with the PrPS 4 type structure (I4 1 /acd; Z = 16). The structure consists of isolated PS 4 tetrahedra each surrounded by four Tb 3+ cations. Both crystallographically different Tb 3+ cations are coordinated by eight sulfur atoms which are part of four PS 4 tetrahedra. Orange single crystals of LiEuPS 4 (a = 11.498(2), c = 19.882(4) Aa) were prepared by reaction of Eu and P with Li 2 S 4 (700 C; 20 h). The crystal structure corresponds to the PrPS 4 type, in which tubes running along [001] are occupied by Li atoms, which are surrounded by four S atoms in strongly distorted tetrahedra. LiS 4 and PS 4 tetrahedra are connected via common edges into alternating chains. (orig.)

  13. An elementary presentation of the PS ''beam control'' system

    International Nuclear Information System (INIS)

    Boussard, D.

    1973-01-01

    The PS synchrotron control system is explained in general terms, covering the topics of frequency control, beam transfer, damping, stability, conservation of longitudinal emittance, and second order problems

  14. RMS Pictorial Scale (RMS-PS: An innovative scale for the assessment of child′s dental anxiety

    Directory of Open Access Journals (Sweden)

    R M Shetty

    2015-01-01

    Full Text Available Background: Dental anxiety assessment for young children is as important as performing their treatment. Appropriate knowledge of patient′s anxiety boosts confidence and will help us to review potential management options specific to every child. Aim: This study aimed to validate (RMS Pictorial Scale (RMS-PS and to compare it with Venham Picture Test (VPT and Facial image scale (FIS in measuring dental anxiety for young children during their first dental visit. Materials and Methods: A total of 102 healthy children aged between 4 and 14 years during their first dental visit were randomly selected for the study. Childs anxiety level was measured using three different scales namely (i RMS-PS (ii VPT, and (iii FIS. Statistical Analysis: Student t test was used to compare the scores obtained from all the three scales. Pearson correlation test was used to obtain correlation among the scales used in the study. Results: A strong correlation (0·76 was found between the VPT and RMS-PS, and a moderate correlation (0.5 was found between RMS-PS and FIS, indicating good validity for the RMS-PS. Conclusions: The findings of this study suggest that the RMS-PS can be a newer and easiest means for the assessment of dental anxiety for young children in a clinical context.

  15. The PS Booster, PS and SPS Magnets for the next 25 years

    CERN Document Server

    Tommasini, D

    2010-01-01

    This note provides information and analysis on the present status of the magnets installed in the CERN Proton Synchrotron Booster (PSB), the Proton Synchrotron (PS) and the Super Proton Synchrotron (SPS) in view of their possible operation for the next 25 years. The note does not cover the magnets installed in the transfer lines, neither it covers the fast injection/extraction magnets (septa and kickers).

  16. High-precision calculation of loosely bound states of LiPs+ and NaPs+

    International Nuclear Information System (INIS)

    Yamashita, Takuma; Kino, Yasushi

    2015-01-01

    A positronic alkali atom would be the first step to investigate behavior of a positronium(Ps) in an external field from atoms/molecules because the system can be regarded as a simple three-body system using model potentials reflecting electron orbitals of the ion core. In order to precisely determine binding energies and structures of positronic alkali atoms (LiPs + and NaPs + ), we improve the model potential so as to reproduce highly excited atomic energy levels of alkali atoms (Li and Na). The polarization potential included by the model potential is expanded in terms of Gaussian functions to finely determine a short range part of the potential which has been assumed to be a simple form. We find better reproducibility not only of atomic levels of the alkali atoms but also of the dipole polarizability of the core ion than previous works. We construct a model potential between a positron and an ion core based on the model potential between the valence electron and ion core. Binding energies associated with a dissociation of the alkali ion core and positronium, and interparticle distances are recalculated. Our results show slightly deeper bound than other previous studies. (paper)

  17. LEADIR-PS: providing unprecedented SMR safety and economics

    Energy Technology Data Exchange (ETDEWEB)

    Hart, R.S., E-mail: N2i2@xplornet.ca [Northern Nuclear Industries Incorporated, Cambridge, ON (Canada)

    2015-07-01

    Northern Nuclear Industries Incorporated (N{sup 2} I{sup 2}) is developing Small Modular Reactors (SMRs) called LEADIR-PS, an acronym for LEAD-cooled Integral Reactor-Passively Safe. LEADIR-PS integrates proven technologies including TRISO fuel, Pebble Bed core and graphite moderator, with molten lead coolant in an integral pool type reactor configuration to achieve unprecedented safety and economics. Plants under development are LEADIR-PS30, producing 30 MWth, LEADIR-PS100 producing 100 MWth and LEADIR-PS300 producing 300 MWth that are focused on serving the energy demands of areas with a small electrical grid and/or process heat applications. A plant consisting of six LEADIR-PS300 reactor modules serving a common turbine-generator, called the LEADIR-PS Six-Pack, is focused on serving areas with higher energy demands and a robust electricity grid. The Gen{sup +} I LEADIR-PS plants are inherently/passively safe. There is no potential for a Loss Of Coolant Accident, a reactivity transient without shutdown, a loss of heat sink, or hydrogen generation. No active systems or operator actions are required to assure safety. The unprecedented safety of LEADIR-PS reactors avoids large exclusion radius and demanding evacuation plan requirements. LEADIR-PS, with steam conditions of 370 {sup o}C and 12 MPa can serve over 85% of the world's non-transportation process heat demands. In Canada, the electricity and process heat demands, ranging from those of remote communities and the oil sands to densely populated areas can be served by LEADIR-PS. (author)

  18. Motor-Generator powering the PS (Proton Synchrotron) main magnets

    CERN Multimedia

    1983-01-01

    This motor-generator,30 MW peak, 1500 r.p.m.,pulsed power supply for the PS main magnet replaced in 1968 the initial 3000 r.p.m. motor-generator-flywheel set which had served from the PS start-up in 1959 until end 1967. See also photo 8302337 and its abstract.

  19. CoPs Facing Rationalization: The Politics of Community Reproduction

    Science.gov (United States)

    Kilskar, Stine Skaufel; Ingvaldsen, Jonas A.; Valle, Nina

    2018-01-01

    Purpose: This paper aims to explore the relationship between the contemporary forms of manufacturing rationalization and the reproduction of communities of practice (CoPs) centred on tasks and craft. Building on critical literature highlighting the tensions between CoPs and rationalization, this paper aims to develop a nuanced account of how CoPs…

  20. Interleaving of beam lines inside the PS tunnel

    CERN Multimedia

    1983-01-01

    View against the direction of the proton beams. The PS ring (section 26) is on the left. The injection tunnel for LEAR leaving from here has increased the trafic in this already busy area where the two Linacs and the transfer tunnel leading to the SPS, ISR and AA join the PS ring (cf. photo 7802260, 7802261, Annual Report 1981, p. 89, fig. 12).

  1. Psühhodraama - spontaansuse kool / Taimi Elenurm

    Index Scriptorium Estoniae

    Elenurm, Taimi

    2010-01-01

    Viinis ja New Yorgis tegutsenud psühhiaatri Jakob Levy Moreno loodud psühhodraamast, mis võimaldab rollimängu kaudu näha ennast läbi teiste silmade, aga ka vabaneda pingetest andes võimaluse käituda teisiti kui tavaelus

  2. Successful online learning – the five Ps

    Directory of Open Access Journals (Sweden)

    Jim FLOOD

    2004-04-01

    Full Text Available Successful online learning – the five Ps Jim FLOOD E-learning Consultant-UK jimflood@btinternet.com Key learning points • An important aspect of design for online learning is visual ergonomics. • Learning theories offer poor predictive power in terms of how learners work and learn. • Success at learning is closely related to emotional engagement–and learning designers tend to ignore this aspect. • Online learning poses a challenging experience for learners–and they need support to cope with it. • A key goal to achieve Praxis – being able to put learning into practice. Many of you will be familiar with the three (or more Ps of marketing and even if not, as trainers or teachers you are likely to have used mnemonics as an aid to retention and recall. Mnemonics are especially useful when you need to get the key points to ‘stick’ in the minds of your audience. With this in mind I offer you the 5 Ps of online learning: Presentation, Pedagogy, Promotion, Preparation and Props. What I offer is not new; in fact much of it results from the eleven years of online teaching and learning at The Open University, the £22 million it has spent on research and evaluation 1, and the worldwide community that have been sharing experience in recent years. You can therefore consider these 5 Ps to be a convenient re-packing of the information and experience that can be found in abundance on the Internet. Presentation Good graphic design appeals to the subtle process by which the brain processes information and, as a result, we decide if we like the ‘look and feel’ of a visual environment. Part of liking this ‘look and feel’ is the way the text and pictorial layout can appear inviting and encouraging–a vital aspect of any online learning environment. Another aspect of presentation is how the text reads in terms of engaging the learner and introducing the story to be told–as well as being written in clear and concise English When browsing through books

  3. Updating the Psoriatic Arthritis (PsA) Core Domain Set

    DEFF Research Database (Denmark)

    Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J

    2017-01-01

    OBJECTIVE: To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). METHODS: At OMERACT 2016, research...... conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants. RESULTS: We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted...... and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA Core Domain Set endorsed with 90% agreement by OMERACT 2016 participants included musculoskeletal disease activity, skin disease activity, fatigue, pain, patient's global assessment, physical function, health...

  4. Autoradiography of the bacterial colony. Application to the effects of polymyxin on the colony of Ps. aeruginosa

    International Nuclear Information System (INIS)

    Reyrolle, Jean; Letellier, Francois; Kauffmann, Jacques

    1975-01-01

    The autoradiography of a colony of Ps.a. which has been transferred, during growth, on a medium added with polymyxin and tritiate leucin makes it possible to locate an upper zone with a high metabolic activity and a basal zone with no metabolic activity. The latter, which consist of lysed cells, acts probably as a selective filter against the drug [fr

  5. Shallow PS-logging by high frequency wave; Koshuha wo mochiita senbu PS kenso

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, A; Miyazawa, M; Azuma, H [OYO Corp., Tokyo (Japan)

    1996-05-01

    This paper describes the following matters on down-hole PS logging in shallow subsurface. Determining an elastic wave velocity structure in shallow subsurface with high accuracy by using down-hole PS logging requires reduction of errors in reading travel time. Therefore, a high-frequency vibration source was fabricated with an objective to raise frequencies of waves used for the measurement. Measurements were made on two holes, A and B, at a measurement interval of 0.5 m, whereas at the hole A a measurement was performed simultaneously by using a normal type (low-frequency) vibration source. A spectral analysis on the waveform record revealed that the frequencies with each vibration source were 127 Hz and 27 Hz for the hole A, 115 Hz for the hole B, and the S/N ratio was all the same for both holes. When the high-frequency vibration source was used, the velocity was determined at accuracy of 5% over the whole length of the shallow section. When the low-frequency vibration source was used, sections with the velocity determining error greater than 5% were found, and it was not possible to derive the velocity structure in the shallow subsurface in fine segments. 3 refs., 8 figs., 2 tabs.

  6. The four Ps of marketing mix in Information Science literature

    OpenAIRE

    Amaral, Sueli Angelica Do

    2000-01-01

    Analisa 60 documentos sobre os 4Ps do composto de marketing cm unidades de informação da literatura de Ciência da Informação no período de 1975 a 1995, para conhecer quantos e quais autores escreveram sobre o tema, qual o pioneiro, quem foi o pioneiro a propor adição de Ps. Apresenta a cronologia dos documentos estudados e discute as 4Ps do composto de marketing. Propõe a adoção da mais completa proposta analisada como forma de garantir o futuro das unidades de informação. ___________________...

  7. Role of trapped and solvated electrons in Ps formation

    International Nuclear Information System (INIS)

    Stepanov, S.V.; Byakov, V.M.; Mikhin, K.V.; He, C.; Hirade, T.

    2005-01-01

    Role of trapped and solvated electrons in Ps formation is discussed. Combination of thermalized positron with such electrons is possible from the view point of the energy balance and may results in Ps formation. This process proceeds during all e = lifetime matter. Fitting of raw experimental e + -e - annihilation spectra has to be based on an adequate physical input, which often leads to necessity of nonexponential deconvolution of the spectra. We have interpreted the Ps formation data in polyethylene, ethylene-methylmethacrylate and polymethylmethacrylate in dark and in light vs. tome of the measurement and temperature. parameters characterized accumulation of trapped electrons and their recombination with counter ions and positrons are obtained. (author)

  8. RF Scenarios for Pb54+ Ions in the PS2

    CERN Document Server

    Benedikt, M; Hancock, S; CERN. Geneva. AB Department

    2008-01-01

    This note analyses some of the rf scenarios that are presently being considered for lead ions in the PS2. An earlier note principally concerning protons [1] highlighted the problem of the large revolution frequency swing of ions in the PS2 and the issue of bunching factor with direct injection from the LEIR machine. We present solutions based on additional rf systems in LEIR and consider the 40 MHz principal rf system proposed for the PS2 in the earlier work to have switchable tuning ranges to cover the large frequency swing required.

  9. New safety training for access to the PS complex areas

    CERN Multimedia

    2012-01-01

    Since 10/08/2012, a new course dedicated to the specific radiological risks in the accelerators of the PS complex has been available on SIR (https://sir.cern.ch/). This course complements the general classroom-based Radiation Safety training. Successful completion of the course will be obligatory and verified by the access system as from 01/11/2012 for access to the following accelerator areas: LINAC2, BOOSTER, PS and TT2. Information and reminder e-mails will be sent to all persons currently authorized to access the accelerators of the PS complex. For questions please contact the HSE unit and in particular, the Radiation Protection Group (+41227672504 or safety-rp-ps-complex@cern.ch).

  10. PS buildings : reinforced concrete structure for shielding "bridge" pillar

    CERN Multimedia

    CERN PhotoLab

    1956-01-01

    The PS ring traverses the region between the experimental halls South and North (buildings Nos 150 and 151) under massive bridge-shaped concrete beams. This pillar stands at the S-W end of the structure.

  11. Proceedings of the workshop on the PS-spin collider

    International Nuclear Information System (INIS)

    Mori, Yoshiharu

    1993-05-01

    This volume is a record of the PS-Spin Collider Workshop which was held at KEK, Jan. 31-Feb.1, 1992. As a future project of the KEK 12-GeV proton synchrotron (KEK-PS), the hadron collider (PS-Collider), has been under discussion. Originally, the PSC was designed for heavy ion beam collisions with the energy range of 5-7 GeV/u. If polarized protons are accelerated in PSC, 19 x 19 GeV collisions are possible. This workshop was proposed to bring together interested experimentalists and accelerator physicists to discuss the case that could be made for polarization physics and the technical feasibility at the PS Spin Collider. More than 30 physicists participated in the workshop and very interesting and useful discussions took place. (author)

  12. DiPS: A Unifying Approach for developing System Software

    OpenAIRE

    Michiels, Sam; Matthijs, Frank; Walravens, Dirk; Verbaeten, Pierre

    2002-01-01

    In this paper we unify three essential features for flexible system software: a component oriented approach, self-adaptation and separation of concerns.We propose DiPS (Distrinet Protocol Stack), a component framework, which offers components, an anonymous interaction model and connectors to handle non-functional aspects such as concurrency. DiPS has effectively been used in industrial protocol stacks and device drivers.

  13. Motor-generator set of the PS main supply

    CERN Multimedia

    Photographic Service; CERN PhotoLab

    1968-01-01

    Already in 1964, the PS improvement programme included a new main magnet supply with more power for the longer cycles needed for slow extraction at the full energy of 26 GeV. This motor-generator set was installed in 1967 and took up service at the beginning of 1968. Regularly serviced and fitted with modern electronic regulation, it pulses the PS to this day.

  14. 1170-MW(t) HTGR-PS/C plant application-study report: alumina-plant application

    International Nuclear Information System (INIS)

    Rao, R.; McMain, A.T. Jr.; Stanley, J.D.

    1981-05-01

    This report considers the HTGR-PS/C application to producing alumina from bauxite. For the size alumina plant considered, the 1170-MW(t) HTGR-PS/C supplies 100% of the process steam and electrical power requirements and produces surplus electrical power and/or process steam, which can be used for other process users or electrical power production. Presently, the bauxite ore is reduced to alumina in plants geographically separated from the electrolysis plant. The electrolysis plants are located near economical electric power sources. However, with the integration of an 1170-MW(t) HTGR-PS/C unit in a commercial alumina plant, the excess electric power available [approx. 233 MW(e)] could be used for alumina electrolysis

  15. The PS will soon be back in operation

    CERN Multimedia

    2006-01-01

    The PS's power supply system is undergoing repairs for the accelerator to restart on 26 June. The AB Department's Power Converter Group is working flat out with Siemens to return the PS's power supply system to working order. A problem appeared on the insulation of the power cables of the rotor of the rotating machine (photo) which supplies power to the PS magnets. To prevent more significant damage to the rotating machine, the AB Department, with the approval of the CERN Management, decided to shut down the PS which had started running on 15 May. Everything is being done to restart the accelerator on 26 June. The PS's rotating machine comprises a motor coupled to a generator. The generator's rotor acts like a flywheel, supplying high-power pulses of 40 to 50 megawatts to the PS magnets. The 6 megawatt motor drives the installation at 1000 revolutions per minute and compensates only for variations in speed. It is an essential interface since it would be hard to imagine connecting such an electrical charge, p...

  16. The new heart of the PS is beating strongly

    CERN Multimedia

    Corinne Pralavorio

    2011-01-01

    The PS has resumed operation with a brand new electrical power system called POPS; this enormous system comprising power electronics and capacitors is crucial because if it broke down practically no particles would be able to circulate at CERN. As soon as it started, POPS passed all the tests with flying colours and is now pulsing at full power.   The new PS power system is made up of 6 containers, each with 60 tonnes of capacitors and 8 power converters. The date 11/02/11 will always be remembered with affection by the engineers in the Electrical Power Converters Group. At 11:11 in the morning (no joke), the first beams powered by the new system began to circulate in the PS. The cutely-named POPS (POwer for PS) took over from the old rotating machine that had been working since 1968. From now on it will be POPS that supplies the PS main magnets with the electrical pulses needed to accelerate the beams for the LHC and all CERN's other facilities. The system is crucial as the PS is one of the lyn...

  17. Burkholderia phytofirmans PsJN reduces damages to freezing temperature in Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Fan eSU

    2015-10-01

    Full Text Available Several plant growth-promoting rhizobacteria (PGPR are known to improve plant tolerance to multiple stresses, including low temperatures. However, mechanisms underlying this protection are still poorly understood. The aim of this study was to evaluate the role of the endophytic PGPR, Burkholderia phytofirmans strain PsJN (Bp PsJN, on Arabidopsis thaliana cold tolerance using photosynthesis parameters as physiological markers.Under standard conditions, our results indicated that Bp PsJN inoculation led to growth promotion of Arabidopsis plants without significant modification on photosynthesis parameters and chloroplast organization. However, bacterial colonization induced a cell wall strengthening in the mesophyllImpact of inoculation modes (either on seeds or by soil irrigation and their effects overnight at 0, -1 or -3°C, were investigated by following photosystem II (PSII activity and gas exchanges. Following low temperatures stress, a decrease of photosynthesis parameters was observed. In addition, during three consecutive nights or days at -1°C, PSII activity was monitored. Pigment contents, RuBisCO protein abundance, expression of several genes including RbcS, RbcL, CBF1, CBF2, CBF3, ICE1, COR15a, and COR78 were evaluated at the end of exposure. To assess the impact of the bacteria on cell ultrastructure under low temperatures, microscopic observations were achieved. Results indicated that freezing treatment induced significant changes in PSII activity as early as the first cold day, whereas the same impact on PSII activity was observed only during the third cold night. The significant effects conferred by PsJN were differential accumulation of pigments, and reduced expression of RbcL and COR78. Microscopical observations showed an alteration/disorganization in A. thaliana leaf mesophyll cells independently of the freezing treatments. The presence of bacteria during the three successive nights or days did not significantly improved A

  18. iPS-Cinderella Story in Cell Biology

    Directory of Open Access Journals (Sweden)

    Editorial

    2010-01-01

    Full Text Available As we step through the frontiers of modern Science, we are all witnesses to the Cinderella story repeating itself in the form of the iPS. The process of re-programming adult somatic cells to derive Induced Pluripotent stem cells (iPS with the wand of transcription factors and then differentiating them back to adult somatic cells resembles the transformation of Cinderella from a Cinder girl to princess and back to a Cinder girl after the ball; but the iPS-Cinderella is the most fascinating thing ever in cell biology!From the day iPS first made its headlines when it was first produced by Shinya Yamanaka at Kyoto University in Japan, Stem Cell scientists all over the world are re- doing their experiments so far done using other sources like embryonic and adult Stem cells with the iPS cells exploring their potential to the fullest. A Stem Cell science news page without this magic word of iPS is difficult to imagine these days and Scientists have been successful in growing most of the adult Cell types from iPS cells.iPS cells was the key to solve the problems of Immune rejection and Immunosupression required when using other allogeneic Stem cell types which had baffled scientists previously. But the issues raised by scientists about the use of viruses and Oncogenes in producing iPS cells were made groundless when scientists in February 2008 published the discovery of a technique that could remove oncogenes after the induction of pluripotency and now it is possible to induce pluripotency using plasmid transfection, piggyback transposon system and piggyback transposon system combined with a non viral vector system. The word of the day is pIPS which are protein-induced Pluripotent stem cells which are iPS cells that were generated without any genetic alteration of the adult cell. This research by the group of Sheng Ding in La Jolla, California made public in April 2009 showed that the generation of poly-arginine anchors was sufficient to induce

  19. PS-CARA: Context-Aware Resource Allocation Scheme for Mobile Public Safety Networks

    Directory of Open Access Journals (Sweden)

    Zeeshan Kaleem

    2018-05-01

    Full Text Available The fifth-generation (5G communications systems are expecting to support users with diverse quality-of-service (QoS requirements. Beside these requirements, the task with utmost importance is to support the emergency communication services during natural or man-made disasters. Most of the conventional base stations are not properly functional during a disaster situation, so deployment of emergency base stations such as mobile personal cell (mPC is crucial. An mPC having moving capability can move in the disaster area to provide emergency communication services. However, mPC deployment causes severe co-channel interference to the users in its vicinity. The problem in the existing resource allocation schemes is its support for static environment, that does not fit well for mPC. So, a resource allocation scheme for mPC users is desired that can dynamically allocate resources based on users’ location and its connection establishment priority. In this paper, we propose a public safety users priority-based context-aware resource allocation (PS-CARA scheme for users sum-rate maximization in disaster environment. Simulations results demonstrate that the proposed PS-CARA scheme can increase the user average and edge rate around 10.3% and 32.8% , respectively because of context information availability and by prioritizing the public safety users. The simulation results ensure that call blocking probability is also reduced considerably under the PS-CARA scheme.

  20. Simultaneous Femtosecond X-ray Spectroscopy and Diffraction of Photosystem II at Room Temperature

    Science.gov (United States)

    Kern, Jan; Alonso-Mori, Roberto; Tran, Rosalie; Hattne, Johan; Gildea, Richard J.; Echols, Nathaniel; Glöckner, Carina; Hellmich, Julia; Laksmono, Hartawan; Sierra, Raymond G.; Lassalle-Kaiser, Benedikt; Koroidov, Sergey; Lampe, Alyssa; Han, Guangye; Gul, Sheraz; DiFiore, Dörte; Milathianaki, Despina; Fry, Alan R.; Miahnahri, Alan; Schafer, Donald W.; Messerschmidt, Marc; Seibert, M. Marvin; Koglin, Jason E.; Sokaras, Dimosthenis; Weng, Tsu-Chien; Sellberg, Jonas; Latimer, Matthew J.; Grosse-Kunstleve, Ralf W.; Zwart, Petrus H.; White, William E.; Glatzel, Pieter; Adams, Paul D.; Bogan, Michael J.; Williams, Garth J.; Boutet, Sébastien; Messinger, Johannes; Zouni, Athina; Sauter, Nicholas K.; Yachandra, Vittal K.; Bergmann, Uwe; Yano, Junko

    2013-01-01

    Intense femtosecond X-ray pulses produced at the Linac Coherent Light Source (LCLS) were used for simultaneous X-ray diffraction (XRD) and X-ray emission spectroscopy (XES) of microcrystals of Photosystem II (PS II) at room temperature. This method probes the overall protein structure and the electronic structure of the Mn4CaO5 cluster in the oxygen-evolving complex of PS II. XRD data are presented from both the dark state (S1) and the first illuminated state (S2) of PS II. Our simultaneous XRD/XES study shows that the PS II crystals are intact during our measurements at the LCLS, not only with respect to the structure of PS II, but also with regard to the electronic structure of the highly radiation sensitive Mn4CaO5 cluster, opening new directions for future dynamics studies. PMID:23413188

  1. Pressure Monitoring Using Hybrid fs/ps Rotational CARS

    Science.gov (United States)

    Kearney, Sean P.; Danehy, Paul M.

    2015-01-01

    We investigate the feasibility of gas-phase pressure measurements at kHz-rates using fs/ps rotational CARS. Femtosecond pump and Stokes pulses impulsively prepare a rotational Raman coherence, which is then probed by a high-energy 6-ps pulse introduced at a time delay from the Raman preparation. Rotational CARS spectra were recorded in N2 contained in a room-temperature gas cell for pressures from 0.1 to 3 atm and probe delays ranging from 10-330 ps. Using published self-broadened collisional linewidth data for N2, both the spectrally integrated coherence decay rate and the spectrally resolved decay were investigated as means for detecting pressure. Shot-averaged and single-laser-shot spectra were interrogated for pressure and the accuracy and precision as a function of probe delay and cell pressure are discussed. Single-shot measurement accuracies were within 0.1 to 6.5% when compared to a transducer values, while the precision was generally between 1% and 6% of measured pressure for probe delays of 200 ps or more, and better than 2% as the delay approached 300 ps. A byproduct of the pressure measurement is an independent but simultaneous measurement of the gas temperature.

  2. Cs0.49NbPS6

    Directory of Open Access Journals (Sweden)

    Hoseop Yun

    2011-01-01

    Full Text Available The quaternary thiophosphate, Cs0.49NbPS6, caesium hexathioniobiophosphate(V, has been synthesized by the reactive halide flux method. The title compound is isotypic with Rb0.46TaPS6 and is made up of a bicapped trigonal–biprismatic [Nb2S12] unit and a tetrahedral [PS4] group. The [Nb2S12] units linked by the [PS4] tetrahedra form infinite chains, yielding a three-dimensional network with rather large van der Waals gaps along the c axis in which the disordered Cs+ ions reside. The electrons released by the Cs atoms are transferred to the pairwise niobium metal site and there are substantial intermetallic Nb—Nb bonding interactions. This leads to a significant decrease of the intermetallic distance in the title compound compared to that in TaPS6. The classical charge balance of the title compound may be represented as [Cs+]0.49[Nb4.51+][P5+][S2−]4[S22−].

  3. SEA and strategy formation theories: From three Ps to five Ps

    International Nuclear Information System (INIS)

    Cherp, Aleh; Watt, Alan; Vinichenko, Vadim

    2007-01-01

    A transition to environmentally sustainable societies should involve a significant and comprehensive - strategic - change. Much of the promise of SEA is associated precisely with its perceived capacity to facilitate such a strategic transformation by influencing selected 'strategic decisions'. This paper examines the potential effectiveness and limitations of such an approach in light of contemporary organizational strategy theories. Most of these theories separate 'strategies' from 'decisions' and also transcend the notion of strategies as formal plans, policies and programs (PPPs). Instead, they consider strategies as 'five Ps', adding 'Position', 'Perspective', 'Pattern' and 'Ploy' to the 'Plan'. Lessons from organizational strategy formation give rise to the following challenges for SEA theory and practice: 1.How to assess and influence informal as well as formal aspects of strategic initiatives? 2.How to extend SEA 'beyond decisions' to address 'emergent strategies' where strategic action is not necessarily preceded by a decision? 3.How to ensure that knowledge provided as a result of SEA is strategically relevant and communicated to key players in strategy formation? 4.How to deal with an uncontrollable and unpredictable environment in which strategic initiatives unfold? 5.How to recognize those situations when SEA can have most strategic influence? This paper takes a step towards examining these challenges by exploring the intellectual history of SEA in light of the main strategy formation theories and by identifying directions in which the SEA discourse may be further enhanced to meet these five challenges

  4. A&T Sector Note on the PS transverse feedback

    CERN Document Server

    Coly, Marcel; Blas, Alfred; Sterbini, Guido; CERN. Geneva. ATS Department

    2017-01-01

    In a particle accelerator, several contributions can degrade the beam quality and particularly the beam transverse emittance. In this document we will describe a system used in the CERN Proton Synchrotron (PS) to cope with the injection steering errors and the transverse instabilities: the PS transverse feedback (PS TFB). As time progresses, this system is also being used for other purpose, to increase in a controlled way the beam transverse emittance and to excite the beam for the Multi-Turn-Extraction (MTE). In 2016, it has been successfully used on some operational beams to damp injection oscillations. This allowed to test the reliability of the system for its operational deployment. A piquet service is available in case of problem.

  5. Framing-camera tube developed for sub-100-ps range

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    A new framing-camera tube, developed by Electronics Engineering, is capable of recording two-dimensional image frames with high spatial resolution in the sub-100-ps range. Framing is performed by streaking a two-dimensional electron image across narrow slits; the resulting electron-line images from the slits are restored into a framed image by a restorer deflector operating synchronously with the dissector deflector. We have demonstrated its performance in a prototype tube by recording 125-ps-duration framed images of 2.5-mm patterns. The limitation in the framing speed is in the external electronic drivers for the deflectors and not in the tube design characteristics. Shorter frame durations (below 100 ps) can be obtained by use of faster deflection drivers

  6. Electrophysical properties of PMN-PT-PS-PFN:Li ceramics

    Directory of Open Access Journals (Sweden)

    R. Skulski

    2013-01-01

    Full Text Available We present the technology of obtaining and the electrophysical properties of a multicomponent material 0.61PMN-0.20PT-0.09PS-0.1PFN:Li (PMN-PT-PS-PFN:Li. The addition of PFN into PMN-PT decreases the temperature of final sintering which is very important during technological process (addition of Li decreases electric conductivity of PFN. Addition of PS i.e., PbSnO3 (which is unstable in ceramic form permits to shift the temperature of the maximum of dielectric permittivity. One-step method of obtaining ceramic samples from oxides and carbonates has been used. XRD, microstructure, scanning calorimetry measurements and the main dielectric, ferroelectric and electromechanical properties have been investigated for the obtained samples.

  7. SAFETY: STRICTER CONTROLS IN CONTROLLED AREAS IN THE PS

    CERN Multimedia

    G. Daems

    2001-01-01

    The PS accelerators will soon stop for several months. Work will take place in controlled areas in the PS and will involve many people who are not always aware of the risks associated with the work sites. To guarentee the safety of these workers, the following two measures will be applied: everyone working in a controlled zone - Linacs, PSB, and PS machines tunnels, and transfer lines - must wear, visibly, his CERN access card and his film badge. the CERN access card and the film badge will only be issued after following a basic safety course. Regular checks will be carried out during the shutdown. Anyone without these two items on their person will be obliged to leave the area immediately.

  8. Evaluation of Recycling Polystyrene (PS) from a Microbiology Product

    OpenAIRE

    Eklöf, Jonas

    2014-01-01

    Detta är ett beställningsarbete av Plastone Oy och i det undersöks möjligheterna vad man kan göra genom återvinning med avfallsmaterialet som uppstår då man tillverkar en mikrobiologisk produkt i deras plastfabrik. Produkten tillverkas genom formsprutning och materialet som används är polystyren (PS). Ur litteraturstudien fann man varierande möjligheter på hur man kan återvinna PS på bästa sätt, men ingen lösning som har varit effektiv i praktiken. Det framgick också att återvunnet PS inte är...

  9. Modular metal chalcogenide chemistry: secondary building blocks as a basis of the silicate-type framework structure of CsLiU(PS_4)_2

    International Nuclear Information System (INIS)

    Neuhausen, Christine; Rocker, Frank; Tremel, Wolfgang

    2012-01-01

    The novel uranium thiophosphate CsLiU(PS_4)_2 has been synthesized by reacting uranium metal, Cs_2S, Li_2S, S, and P_2S_5 at 700 C in an evacuated silica tube. The crystal structure was determined by single-crystal X-ray diffraction techniques. CsLiU(PS_4)_2 crystallizes in the rhombohedral space group R anti 3c (a = 15.2797(7) Aa; c = 28.778(2) Aa, V = 5818.7(5) Aa"3, Z = 18). The structure of CsLiU(PS_4)_2 is a unique three-dimensional U(PS_4)_2"2"- framework with large tunnels with an approximate diameter of 6.6 Aa running parallel to the crystallographic c axis. The tunnels are filled with Cs"+ cations. The smaller Li"+ cations are located at tetrahedral sites at the periphery of the channels. In the structure of CsLiU(PS_4)_2 the uranium atoms are coordinated by thiophosphate groups in a pseudotetrahedral fashion, and the PS_4 groups act as linear connectors. Topologically, CsLiU(PS_4)_2 may be regarded a chalcogenide analogue of silicate frameworks, with the uranium atoms and PS_4 groups replacing silicon and oxygen atoms. Alternatively, CsLiU(PS_4)_2 may be viewed as a coordination polymer, which is formed in salt melts by the solid state equivalent of the ''self-assembly'' reactions in solution. Magnetic susceptibility measurements indicated Curie-Weiss-type behavior between 4 K and 300 K. The μ_e_f_f of 2.83 μ_B at 300 K is in agreement with an f"2 configuration of U"4"+. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  10. Multiple bunch-splitting in the PS results and plans

    CERN Document Server

    Garoby, R

    2001-01-01

    The nominal longitudinal characteristics of the PS proton beam for the LHC were attained during the year 2000, using a sequence of triple- and double-splittings to divide each PS Booster (PSB) bunch into 12. This method minimizes longitudinal emittance blow-up and preserves a gap, free of particles, in the bunch train. Some of the ideas for alternative bunch trains have also been tested. The performance achieved is described and the sources of limitations are discussed together with the foreseen improvements.

  11. Look into the PS Main Control Room (partial view)

    CERN Multimedia

    1974-01-01

    Jean-Pierre Potier at work. The 26 GeV Synchrotron and later also its related machines (Linacs 1,2,3; PS-Booster, LEP-Injector Linacs and Electron-Positron Accumulator; Antiproton Accumulator, Antiproton Collector, Low Energy Antiproton Ring and more recently Antiproton Decelerator) were all controlled from the PS control room situated at the Meyrin site. The SPS and LEP were controlled from a separat control centre on the Prevessin site. In 2005 all controls were transferred to the Prevessin centre.

  12. Preliminary Specifications for the PS Transverse Damper Control Interface

    CERN Document Server

    Blas, A

    2003-01-01

    The transverse feedback system foreseen for the PS in 2004 is composed of different units to be remotely controlled and monitored: the pick-up amplifiers, the DSPU, the fine delay, the driver and power amplifiers. A special VME unit being dedicated to the pick-up amplifier ("The VMOD-TRX: a device for communication with remote instrumentation", A. Barreira Sevillano, J. Belleman, PS/BD/Note 96-02), the new interface will have to deal with the remaining parts of the loop.

  13. HiPS - Hierarchical Progressive Survey Version 1.0

    Science.gov (United States)

    Fernique, Pierre; Allen, Mark; Boch, Thomas; Donaldson, Tom; Durand, Daniel; Ebisawa, Ken; Michel, Laurent; Salgado, Jesus; Stoehr, Felix; Fernique, Pierre

    2017-05-01

    This document presents HiPS, a hierarchical scheme for the description, storage and access of sky survey data. The system is based on hierarchical tiling of sky regions at finer and finer spatial resolution which facilitates a progressive view of a survey, and supports multi-resolution zooming and panning. HiPS uses the HEALPix tessellation of the sky as the basis for the scheme and is implemented as a simple file structure with a direct indexing scheme that leads to practical implementations.

  14. Inauguration of POPS: the new power system of the PS

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    Pictures 03 and 04 : The team from the Electrical Power Converters Group (TE/EPC) is joined by the Director of Accelerators, the heads of the BE, TE and FI departments, CERN managers and Converteam representatives in a group portrait in front of three of the containers that house the capacitor banks of the PS's new power supply system, POPS. Pictures 01, 06 and 07 : Magid-Michel Saikaly, energy and infrastructure director at Converteam, receives a prize from Steve Myers, Director of Accelerators at CERN, for the development and fabrication of the new electrical power system for the PS, called POPS.

  15. Synthesis and Characterization of the Rubidium Thiophosphate Rb 6 (PS 5 )(P 2 S 10 ) and the Rubidium Silver Thiophosphates Rb 2 AgPS 4 , RbAg 5 (PS 4 ) 2 and Rb 3 Ag 9 (PS 4 ) 4

    KAUST Repository

    Alahmary, Fatimah S.; Davaasuren, Bambar; Khanderi, Jayaprakash; Rothenberger, Alexander

    2016-01-01

    The metal thiophosphates Rb2AgPS4 (2), RbAg5(PS4)2 (3), and Rb3Ag9(PS4)4 (4) were synthesized by stoichiometric reactions, whereas Rb6(PS5)(P2S10) (1) was prepared with excess amount of sulfur. The compounds crystallize as follows: 1 monoclinic, P21

  16. The OMERACT psoriatic arthritis magnetic resonance imaging scoring system (PsAMRIS): definitions of key pathologies, suggested MRI sequences, and preliminary scoring system for PsA Hands

    DEFF Research Database (Denmark)

    Østergaard, Mikkel; McQueen, Fiona; Wiell, Charlotte

    2009-01-01

    This article describes a preliminary OMERACT psoriatic arthritis magnetic resonance image scoring system (PsAMRIS) for evaluation of inflammatory and destructive changes in PsA hands, which was developed by the international OMERACT MRI in inflammatory arthritis group. MRI definitions of important...... pathologies in peripheral PsA and suggestions concerning appropriate MRI sequences for use in PsA hands are also provided....

  17. Multipole stack for the 4 rings of the PS Booster

    CERN Multimedia

    CERN PhotoLab

    1976-01-01

    The PS Booster (originally 800 MeV, now 1.4 GeV) saw first beam in 1972, routine operation began in 1973. The strive for ever higher intensities required the addition of multipoles. Manufacture of 8 stacks of multipoles was launched in 1974, for installation in 1976. For details, see 7511120X.

  18. Microproteins (miPs) - the next big thing.

    Science.gov (United States)

    Feller, Stephan

    2012-12-18

    With iPS cells, sncRNAs, chromatin modification regulation and cancer stem cells already cooling off again, i.e. not being guaranteed publications in the 'ultimate' journals anymore, what will be very soon the new red-hot (or super-cool, i.e. anything but lukewarm) 'kid on the block'? We would vote for microproteins.

  19. checkCIF/PLATON report Datablock: ps75

    Indian Academy of Sciences (India)

    THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors found. CIF dictionary Interpreting this report. Datablock: ps75. Bond precision:.

  20. Microproteins (miPs – the next big thing

    Directory of Open Access Journals (Sweden)

    Feller Stephan

    2012-12-01

    Full Text Available Abstract With iPS cells, sncRNAs, chromatin modification regulation and cancer stem cells already cooling off again, i.e. not being guaranteed publications in the 'ultimate' journals anymore, what will be very soon the new red-hot (or super-cool, i.e. anything but lukewarm 'kid on the block'? We would vote for microproteins.

  1. Thermal stability of gold-PS nanocomposites thin films

    Indian Academy of Sciences (India)

    Low-temperature transmission electron microscopy (TEM) studies were performed on polystyrene (PS, w = 234 K) – Au nanoparticle composite thin films that were annealed up to 350°C under reduced pressure conditions. The composite thin films were prepared by wet chemical approach and the samples were then ...

  2. (PS)2: protein structure prediction server version 3.0.

    Science.gov (United States)

    Huang, Tsun-Tsao; Hwang, Jenn-Kang; Chen, Chu-Huang; Chu, Chih-Sheng; Lee, Chi-Wen; Chen, Chih-Chieh

    2015-07-01

    Protein complexes are involved in many biological processes. Examining coupling between subunits of a complex would be useful to understand the molecular basis of protein function. Here, our updated (PS)(2) web server predicts the three-dimensional structures of protein complexes based on comparative modeling; furthermore, this server examines the coupling between subunits of the predicted complex by combining structural and evolutionary considerations. The predicted complex structure could be indicated and visualized by Java-based 3D graphics viewers and the structural and evolutionary profiles are shown and compared chain-by-chain. For each subunit, considerations with or without the packing contribution of other subunits cause the differences in similarities between structural and evolutionary profiles, and these differences imply which form, complex or monomeric, is preferred in the biological condition for the subunit. We believe that the (PS)(2) server would be a useful tool for biologists who are interested not only in the structures of protein complexes but also in the coupling between subunits of the complexes. The (PS)(2) is freely available at http://ps2v3.life.nctu.edu.tw/. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  3. Analysis of Land Deformation on Slope Area using PS InSAR. Case Study: Malang Area

    International Nuclear Information System (INIS)

    Sudiana, Dodi; Rizkinia, Mia; Arief, Rahmat; Rokhmatuloh; Ardiansyah; Setiadi, Bambang; Bayuaji, Luhur; Sri Sumantyo, Josaphat Tetuko

    2014-01-01

    The geographical position of Indonesia located between two continents and oceans is strategic, but at large risk of experiencing various disasters. Climate change and vulnerable location (surrounded by plates and geological faults in the Earth's crust) creates an earthquake-prone region and causes land/mudslides. In this paper, PS InSAR method (Persistent Scatterer Interferometric Synthetic Aperture Radar) is implemented to Phased Array type L-band Synthetic Aperture Radar (PALSAR) data to study the potential damage caused by the earthquake or volcanic eruption in Malang vicinity. By comparing the amplitude images periodically, shifting soil can be determined using precise orbital information. The analysis showed a significant decrease of land deformation on slope area in Klojen district in Malang city, reached up to −7.128 mm/year

  4. Understanding Laterally Varying Path Effects on P/S Ratios and their Effectiveness for Event Discrimination at Local Distances

    Science.gov (United States)

    Pyle, M. L.; Walter, W. R.

    2017-12-01

    Discrimination between underground explosions and naturally occurring earthquakes is an important endeavor for global security and test-ban treaty monitoring, and ratios of seismic P to S-wave amplitudes at regional distances have proven to be an effective discriminant. The use of the P/S ratio is rooted in the idea that explosive sources should theoretically only generate compressional energy. While, in practice, shear energy is observed from explosions, generally when corrections are made for magnitude and distance, P/S ratios from explosions are higher than those from surrounding earthquakes. At local distances (chemical explosions at the Nevada National Security Site (NNSS) designed to improve our understanding and modeling capabilities of shear waves generated by explosions. Phase I consisted of 5 explosions in granite and Phase II will move to a contrasting dry alluvium geology. We apply a high-resolution 2D attenuation model to events near the NNSS to examine what effect path plays in local P/S ratios, and how well an earthquake-derived model can account for shallower explosion paths. The model incorporates both intrinsic attenuation and scattering effects and extends to 16 Hz, allowing us to make lateral path corrections and consider high-frequency ratios. Preliminary work suggests that while 2D path corrections modestly improve earthquake amplitude predictions, explosion amplitudes are not well matched, and so P/S ratios do not necessarily improve. Further work is needed to better understand the uses and limitation of 2D path corrections for local P/S ratios.

  5. psíquico de um caps em florianópolis

    Directory of Open Access Journals (Sweden)

    Dorotéa Loes Ribas

    2007-01-01

    Full Text Available En el presente estudio se realizó una investigación cualitativa cuyo objetivo fue reflexionar, con el individuo en sufrimiento psíquico, sus experiencias vividas en el cotidiano, identificando los significados de estas experiencias. El estudio fue realizado con dos clientes de un Centro de Atención Psicosocial (CAPS II, en la ciudad de Florianópolis. La recolección de los datos fue hecha a partir de la implantación del proceso de cuidado, según la Teoría de Rosemarie Rizzo Parse. En el análisis de los datos fueron identificados los siguientes significados: conviviendo con los recuerdos de la infancia; la co-constitución de la enfermedad psiquiátrica; el trabajo penetrando el proceso salud-enfermedad; transcendiendo en salud, ciudadanía y calidad de vida; iluminados por la Reforma de la Asistencia Psiquiátrica. De esa forma, la teoría “Volverse Humano”, con sus conceptos, principios y presupuestos le permitió al individuo en sufrimiento psíquico vislumbrar una nueva manera de vivir, relacionada con la propuesta de la Reforma Psiquiátrica Brasileña.

  6. A transmissão psíquica geracional

    Directory of Open Access Journals (Sweden)

    Vinícius Oliveira dos Santos

    Full Text Available O artigo seguinte refere-se a um estudo sobre como ocorre a transmissão psíquica entre as gerações e qual sua importância na constituição psíquica do sujeito. É também objetivo deste artigo explicar o que são as transmissões intergeracional e transgeracional. Para buscar respostas para essas questões, fez-se uma pesquisa bibliográfica sobre a transmissão psíquica, pelo viés psicanalítico, principalmente a partir da teoria lacaniana e com conceitos oriundos da linguística saussuriana. Será a partir de uma determinada ordem simbólica, constituída pela linguagem que precede o sujeito, nomeado por Lacan como o Outro, que a transmissão psíquica entre gerações ganhará o seu caráter unívoco, sempre se tendo em mente a importância fundamental do recalcamento e de seus efeitos, bem como do retorno do recalcado nas diferentes gerações. A transmissão psíquica é necessária e concomitante à constituição do sujeito, e ocorre através da linguagem, dos significantes que irão determinar uma ordem simbólica para o ser que nasce através dos diferentes discursos que perpassam as gerações nas figuras dos pais desse novo ser. Essa ordem simbólica continuará a se fazer presente nesse novo sujeito pelo restante de sua existência. Este artigo busca dar nova luz ao aspecto da transmissão psíquica transgeracional, diferenciando-se da recalque s abordagens psicanalíticas contemporâneas por ser uma leitura lacaniana. Serão usados dois exemplos: um de como a transmissão aparece na cultura, outro, na subjetividade do sujeito através da arte.

  7. Spectra and relaxation dynamics of the pseudohalide (PS) vibrational bands for Ru(bpy)2(PS)2 complexes, PS = CN, NCS and N3

    International Nuclear Information System (INIS)

    Compton, Ryan; Gerardi, Helen K.; Weidinger, Daniel; Brown, Douglas J.; Dressick, Walter J.; Heilweil, Edwin J.; Owrutsky, Jeffrey C.

    2013-01-01

    Highlights: ► Static and transient infrared spectroscopy of pseudohalide bipyridine ruthenium complexes. ► Vibrational energy relaxes faster for the azide than the thiocyanate and cyanide analogs. ► Intramolecular vibrational relaxation is prevalent in cis-Ru(bpy) 2 (N 3 ) 2 . - Abstract: Static and transient infrared spectroscopy were used to investigate cis-Ru(bpy) 2 (N 3 ) 2 (bpy = 2,2′-bipyridine), cis-Ru(bpy) 2 (NCS) 2 , and cis-Ru(bpy) 2 (CN) 2 in solution. The NC stretching IR band for cis-Ru(bpy) 2 (NCS) 2 appears at higher frequency (∼2106 cm −1 in DMSO) than for the free NCS − anion while the IR bands for the azide and cyanide complexes are closer to those of the respective free anions. The vibrational energy relaxation (VER) lifetime for the azide complex is found to be much shorter (∼5 ps) than for either the NCS or CN species (both ∼70 ps in DMSO) and the lifetimes resemble those for each corresponding free anion in solution. However, for cis-Ru(bpy) 2 (N 3 ) 2 , it is determined that the transition frequency depends more on the solvent than the VER lifetime implying that intramolecular vibrational relaxation is predominant over solvent energy-extracting interactions. These results are compared to the behavior of other related metal complexes in solution

  8. The CERN PS/SL Controls Java Application Programming Interface

    International Nuclear Information System (INIS)

    I. Deloose; J. Cuperus; P. Charrue; F. DiMaio; K. Kostro; M. Vanden Eynden; W. Watson

    1999-01-01

    The PS/SL Convergence Project was launched in March 1998. Its objective is to deliver a common control as infrastructure for the CERN accelerators by year 2001. In the framework of this convergence activity, a project was launched to develop a Java Application Programming Interface (API) between programs written in the Java language and the PS and SL accelerator equipment. This Java API was specified and developed in collaboration with TJNAF. It is based on the Java CDEV [1] package that has been extended in order to end up with a CERN/TJNAF common product. It implements a detailed model composed of devices organized in named classes that provide a property-based interface. It supports data subscription and introspection facilities. The device model is presented and the capabilities of the API are described with syntax examples. The software architecture is also described

  9. Longitudinal coupled-bunch instability studies in the PS

    CERN Document Server

    Damerau, H

    2017-01-01

    The main longitudinal limitation for LHC-type beams inthe PS are coupled-bunch instabilities. A dedicated proto-typefeedbacksystemusingaFinemetcavityasalongitudinalkicker has been installed. Extensive tests with beam havebeen performed to explore the intensity reach with this feed-back. The maximum intensity with nominal longitudinalemittance at PS extraction has been measured, as well as theemittance required to keep the beam longitudinally stableat the design intensity for the High-Luminosity LHC (HL-LHC). A higher-harmonic cavity is a complementary op-tion to extend the intensity reach beyond the capabilities ofthe coupled-bunch feedback. Preliminary machine develop-ment (MD) studies operating one20MHzor one40MHzRF system as a higher harmonic at the flat-top indicate thebeneficial effect on longitudinal beam stability

  10. Laboratory spectrum of the PS radical and related astronomical search

    International Nuclear Information System (INIS)

    Ohishi, M.; Yamamoto, S.; Saito, S.; Kawaguchi, K.; Suzuki, H.

    1988-01-01

    The millimeter-wave rotational spectrum of the PS radical (X 2Pi r) was observed in the laboratory for the first time in the frequency region of 79-293 GHz by discharging the mixture of PSCl3 and He. Some 44 lines were measured, and the rotational constant, the centrifugal distortion constant, the centrifugal distortion term of the spin-orbit coupling constant, the Lambda-type doubling constants, and the hyperfine coupling constants were determined. Based on the measured and calculated frequencies, an astronomical search for the interstellar and circumstellar PS radical was made without success in Orion KL, Sgr B2, L134N,IRC + 10216, VY CMa, and OH 231.8 + 4.2. 29 references

  11. O Trabalho Psíquico da Intersubjetividade

    Directory of Open Access Journals (Sweden)

    Maria Inês Assumpção Fernandes

    2003-01-01

    Full Text Available O presente trabalho procura refletir sobre o trabalho psíquico da intersubjetividade nos grupos. Trata-se de pensá-lo na relação com a ruptura de investimentos durante o processo de Transformação x Criação, em primeiro lugar. A partir desse ponto, discutiremos a relação entre Transformação, Trabalho e Dispositivo. Neste caso pensamos nas possibilidades de intervenção, refletindo sobre a intervenção inpidual e a intervenção grupal. A questão da Transmissão Psíquica entre gerações será focalizada, fundamentalmente, no que se refere aos tempos lógicos do recalque.

  12. Four-frame gated optical imager with 120-ps resolution

    International Nuclear Information System (INIS)

    Young, P.E.; Hares, J.D.; Kilkenny, J.D.; Phillion, D.W.; Campbell, E.M.

    1988-04-01

    In this paper we describe the operation and applications of a framing camera capable of four separate two-dimensional images with each frame having a 120-ps gate width. Fast gating of a single frame is accomplished by using a wafer image intensifier tube in which the cathode is capacitively coupled to an external electrode placed outside of the photocathode of the tube. This electrode is then pulsed relative to the microchannel plate by a narrow (120 ps), high-voltage pulse. Multiple frames are obtained by using multiple gated tubes which share a single bias supply and pulser with relative gate times selected by the cable lengths between the tubes and the pulser. A beamsplitter system has been constructed which produces a separate image for each tube from a single scene. Applications of the framing camera to inertial confinement fusion experiments are discussed

  13. Transfer line from the PSB to the PS (recombination)

    CERN Multimedia

    CERN PhotoLab

    1976-01-01

    After sequential ejection of 5 bunches from each of the 4 rings of the Booster (originally 800 MeV, now 1.4 GeV), the 4 batches are brought to the same vertical level, so as to form a string of 20 bunches, filling the circumference of the PS. This vertical "recombination" is performed in the transfer line, using vertical bending magnets, septa and kickers. Here we see the section where the beam from ring 4 (the top one) is brought down to the level of ring 3, and the beam from ring 1 up to the level of ring 2. Further downstream (to the right, outside this picture), level 2 is brought up to level 3, identical to that of the PS. After this original recombination scheme, other ways of combining the 4 beams, vertically and/or longitudinally, were developed and used in operation.

  14. Ps beam production and scattering from gaseous targets

    International Nuclear Information System (INIS)

    Garner, A.J.; Laricchia, G.; Oezen, A.

    1996-01-01

    We have investigated the conversion of a positron beam into an ortho-Ps beam via charge exchange in gaseous H 2 , He and Ar at energies up to 120 eV and gas pressures up to 14 μmHg. H 2 has been found to be the most efficient converter at energies up to 90 eV. At higher energies, Ar has been found to be the best. Total cross sections of ortho-Ps scattering from H 2 and He have also been measured. A comparison with available theories suggests that electron exchange at lower energies and target inelastic collisions at higher energies are playing a major role in the collisions. (author)

  15. Images of Christ's Saving Work in Ps.-Epiphanius' Homilies

    Directory of Open Access Journals (Sweden)

    H. F. Stander

    1997-12-01

    Full Text Available Images of Christ's Saving Work in Ps.-Epiphanius' Homilies. One cannot really speak of a systematic theology on the subject of atone-ment in the patristic writers. Frances Young once said that 'it is in fact impossible to categorize neatly the thought of the major patristic writers on the subject of atonement'. She adds that one cannot do justice to the range of motifs and images that are found in describing the saving and atoning work of Christ if we merely dismember 'systematic theologies' to illustrate common soteriological themes. One can only appreciate patristic views of atonement if one begins by recognizing the multifaceted unity of imagery that pervades the literature. This then is the goal of this article: to discuss the rich images which Ps: -Epiphanius uses to describe the atoning work of Christ.

  16. Development of a 64-channel 100 ps TDC module

    International Nuclear Information System (INIS)

    Liu Xiaohua; An Qi; Liu Shubin; Su Hong; Zhan Wenlong

    2009-01-01

    Multi-wire drift chamber at external target experiment in HIRFL-CSR measures drift time of charged particles to obtain the track information. A 64-channel TDC module hosting high density connectors and high performance TDC chips (HPTDC) are used to perform the time digitization. Data of the module is transferred to computer through PXI bus. The test results show that a 100 ps resolution has been achieved. (authors)

  17. The four "P"s of marketing are dead.

    Science.gov (United States)

    English, J

    2000-01-01

    For several decades marketing planning in the United States has relied upon the "four Ps" model. Product, price, place, and promotion were considered the foundation of the marketing mix. This model, however, has never been a comfortable fit for health care and, as the new century dawns, we find that a new marketing model--emphasizing the "four Rs"--is emerging. The foundations of the new model are relevance, response, relationships, and results.

  18. Physics at the AD/PS/SPS (1/4)

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    Lecture 1: The CERN injector complex and beams for non-LHC physics. The various machines and beam lines in the CERN injector complex are presented, from the linacs to the SPS. Special emphasis is given to the beam lines at the PS and SPS machines: AD, North and East Areas, nTOF and CNGS and HiRadMad as well as the ion beams. A short outlook is given to possible future upgrades and projects.

  19. The Pan-STARRS PS1 Image Processing Pipeline

    Science.gov (United States)

    Magnier, E.

    The Pan-STARRS PS1 Image Processing Pipeline (IPP) performs the image processing and data analysis tasks needed to enable the scientific use of the images obtained by the Pan-STARRS PS1 prototype telescope. The primary goals of the IPP are to process the science images from the Pan-STARRS telescopes and make the results available to other systems within Pan-STARRS. It also is responsible for combining all of the science images in a given filter into a single representation of the non-variable component of the night sky defined as the "Static Sky". To achieve these goals, the IPP also performs other analysis functions to generate the calibrations needed in the science image processing, and to occasionally use the derived data to generate improved astrometric and photometric reference catalogs. It also provides the infrastructure needed to store the incoming data and the resulting data products. The IPP inherits lessons learned, and in some cases code and prototype code, from several other astronomy image analysis systems, including Imcat (Kaiser), the Sloan Digital Sky Survey (REF), the Elixir system (Magnier & Cuillandre), and Vista (Tonry). Imcat and Vista have a large number of robust image processing functions. SDSS has demonstrated a working analysis pipeline and large-scale databasesystem for a dedicated project. The Elixir system has demonstrated an automatic image processing system and an object database system for operational usage. This talk will present an overview of the IPP architecture, functional flow, code development structure, and selected analysis algorithms. Also discussed is the HW highly parallel HW configuration necessary to support PS1 operational requirements. Finally, results are presented of the processing of images collected during PS1 early commissioning tasks utilizing the Pan-STARRS Test Camera #3.

  20. A complete classification of minimal non-PS-groups

    Indian Academy of Sciences (India)

    Abstract. Let G be a finite group. A subgroup H of G is called s-permutable in G if it permutes with every Sylow subgroup of G, and G is called a PS-group if all minimal subgroups and cyclic subgroups with order 4 of G are s-permutable in G. In this paper, we give a complete classification of finite groups which are not ...

  1. Study of an energy upgrade of the CERN PS Booster

    CERN Document Server

    Hanke, K; Angoletta, M E; Bartmann, W; Bartolome, S; Bertone, C; Blas, A; Borburgh, J; Bozzini, D; Butterworth, A; Carli, C; Dahlen, P; Dobers, T; Findlay, A; Folch, R; Gilbert, N; Hansen, J; Hermanns, T; Jensen, S; Le Roux, P; Lopez-Hernandez, L A; Mahner, E; Masi, A; Mikulec, B; Muttoni, Y; Newborough, A; Nisbet, D; Nonis, M; Olek, S; Paoluzzi, M; Pittet, S; Puccio, B; Raginel, V; Ruehl, I; Tan, J; Todd, B; Weterings, W; Widorski, W

    2011-01-01

    CERN’s LHC injector chain will have to deliver beams with ultimate brilliance as the LHC is heading for increased luminosity in the coming years. In order to overcome bottlenecks in the injector chain, an increase of the beam transfer energy from the CERN Proton Synchrotron Booster (PSB) to the Proton Synchrotron (PS) has been investigated as a possible upgrade scenario. This paper gives an overview of the technical solutions and summarizes the conclusions of the feasibility study.

  2. PS3 CELL Development for Scientific Computation and Research

    Science.gov (United States)

    Christiansen, M.; Sevre, E.; Wang, S. M.; Yuen, D. A.; Liu, S.; Lyness, M. D.; Broten, M.

    2007-12-01

    The Cell processor is one of the most powerful processors on the market, and researchers in the earth sciences may find its parallel architecture to be very useful. A cell processor, with 7 cores, can easily be obtained for experimentation by purchasing a PlayStation 3 (PS3) and installing linux and the IBM SDK. Each core of the PS3 is capable of 25 GFLOPS giving a potential limit of 150 GFLOPS when using all 6 SPUs (synergistic processing units) by using vectorized algorithms. We have used the Cell's computational power to create a program which takes simulated tsunami datasets, parses them, and returns a colorized height field image using ray casting techniques. As expected, the time required to create an image is inversely proportional to the number of SPUs used. We believe that this trend will continue when multiple PS3s are chained using OpenMP functionality and are in the process of researching this. By using the Cell to visualize tsunami data, we have found that its greatest feature is its power. This fact entwines well with the needs of the scientific community where the limiting factor is time. Any algorithm, such as the heat equation, that can be subdivided into multiple parts can take advantage of the PS3 Cell's ability to split the computations across the 6 SPUs reducing required run time by one sixth. Further vectorization of the code can allow for 4 simultanious floating point operations by using the SIMD (single instruction multiple data) capabilities of the SPU increasing efficiency 24 times.

  3. Future perspective of meson spectroscopy studies at KEK-PS

    International Nuclear Information System (INIS)

    Tsuru, T.

    1992-01-01

    Physics of light-quark meson spectroscopy at present is simply reviewed and a direction of next generation experiment is investigated. A new charge and gamma spectrometer is proposed to push forward next generation physics at KEK-PS. It should have almost 4π acceptance for both charged particles and gamma's and have options of π/K separation and good π 0 /γ separation. (author)

  4. Functional characterization of calcineurin homologs PsCNA1/PsCNB1 in Puccinia striiformis f. sp. tritici using a host-induced RNAi system.

    Directory of Open Access Journals (Sweden)

    Hong Zhang

    Full Text Available Calcineurin plays a key role in morphogenesis, pathogenesis and drug resistance in most fungi. However, the function of calcineurin genes in Puccinia striiformis f. sp. tritici (Pst is unclear. We identified and characterized the calcineurin genes PsCNA1 and PsCNB1 in Pst. Phylogenetic analyses indicate that PsCNA1 and PsCNB1 form a calcium/calmodulin regulated protein phosphatase belonging to the calcineurin heterodimers composed of subunits A and B. Quantitative RT-PCR analyses revealed that both PsCNA1 and PsCNB1 expression reached their maximum in the stage of haustorium formation, which is one day after inoculation. Using barely stripe mosaic virus (BSMV as a transient expression vector in wheat, the expression of PsCNA1 and PsCNB1 in Pst was suppressed, leading to slower extension of fungal hyphae and reduced production of urediospores. The immune-suppressive drugs cyclosporin A and FK506 markedly reduced the germination rates of urediospores, and when germination did occur, more than two germtubes were produced. These results suggest that the calcineurin signaling pathway participates in stripe rust morphogenetic differentiation, especially the formation of haustoria during the early stage of infection and during the production of urediospores. Therefore PsCNA1 and PsCNB1 can be considered important pathogenicity genes involved in the wheat-Pst interaction.

  5. New Electron Cloud Detectors for the PS Main Magnets

    CERN Document Server

    Yin Vallgren, Ch; Gilardoni, S; Taborelli, M; Neupert, H; Ferreira Somoza, J

    2014-01-01

    Electron cloud (EC) has already been observed during normal operation of the PS, therefore it is necessary to study its in fluence on any beam instability for the future LHC Injector Upgrade (LIU). Two new electron cloud detectors have been discussed, developed and installed during the Long Shutdown (LS1) in one of the PS main magnets. The first measurement method is based on current measurement by using a shielded button-type pick-up. Due to the geometry and space limitation in the PS magnet, the button-type pick-up made of a 96%Al2O3 block coated with a thin layer of solvent-based Ag painting, placed 30 degrees to the bottom part of the vacuum chamber was installed in the horizontal direction where the only opening of the magnet coil is. The other newly developed measurement method is based on detection of photons emitted by the electrons from the electron cloud impinging on the vacuum chamber walls. The emitted photons are reected to a quartz window. A MCP-PMT (Micro-Channel Plate Photomultiplier Tube) wit...

  6. Physics with primary beams of the KEK-PS

    International Nuclear Information System (INIS)

    Tanaka, Kazuhiro; Yoshii, Masahito

    1993-08-01

    The 12-GeV Proton Synchrotron (PS) at the National Laboratory for High Energy Physics (KEK) has provided great opportunities to high-energy-physics and related communities as a unique high-energy hadron machine, since its operation in 1976. Activities of the KEK-PS are indispensable for the rapid development in the field. Six experimental subjects are proposed in this Report; (1) media effects in φ meson decay, (2) multifragmentation in high-energy reactions, (3) mechanism of high-energy reactions by means of radio-chemical methods, (4) physics with polarized high-energy neutrons, (5) physics with polarized high-energy deuterons, and (6) hypernucleus with high-energy heavy-ion beams. As a summary, new facilities (a new injector, a new beamline and a new experimental area) and physics programs with primary beams, proposed in this Report are themselves unique and valuable. Moreover, technical developments and physics outcomes stimulated with those new facilities are indispensable for future plans of the KEK-PS. (J.P.N.)

  7. LS1 Report: PS Booster prepares for beam

    CERN Multimedia

    Katarina Anthony

    2014-01-01

    With Linac2 already up and running, the countdown to beam in the LHC has begun! The next in line is the PS Booster, which will close up shop to engineers early next week. The injector will be handed over to the Operations Group who are tasked with getting it ready for active duty.   Taken as we approach the end of LS1 activities, this image shows where protons will soon be injected from Linac2 into the four PS Booster rings. Over the coming two months, the Operations Group will be putting the Booster's new elements through their paces. "Because of the wide range of upgrades and repairs carried out in the Booster, we have a very full schedule of tests planned for the machine," says Bettina Mikulec, PS Booster Engineer in Charge. "We will begin with cold checks; these are a wide range of tests carried out without beam, including system tests with power on/off and with varying settings, as well as verification of the controls system and timings." Amon...

  8. Network structure control of binary mixed langmuir monolayers of homo-PS and PS-b-P2VP.

    Science.gov (United States)

    Wen, Gangyao

    2010-03-25

    Our recent work showed there existed a composition window for mixed Langmuir monolayers of homopolystyrene (h-PS) and a symmetric diblock copolymer polystyrene-block-poly(2-vinylpyridine) (PS-b-P2VP) to form necklace-network structures at the air/water interface. In order to study further the possible mechanism and control the network structure (i.e., surface coverage and nanoaggregate diameter), effects of spreading solution concentration and volume, subphase temperature, and transfer pressure on the network structure were studied by the Langmuir monolayer technique and tapping mode atomic force microscopy. With the increase of transfer pressure, there existed a novel nonlinear behavior for the nanoaggregate diameter first to increase, then to decrease, and finally to increase again, while the surface coverage tended to increase step by step. Moreover, with the elevation of temperature, chain motion between the adjoining nanoaggregates tended to be improved and thus the nanoaggregate diameter tended to be more uniform.

  9. Psühholoog Pulver: uskumatu. Kurb. Õõvastav / Aleksander Pulver ; intervjueerinud Tiina Jõgeda

    Index Scriptorium Estoniae

    Pulver, Aleksander, 1956-

    2009-01-01

    Vestlus Tallinna Ülikooli psühholoogia instituudi direktori Aleksander Pulveriga pedofiilia teemal. Psühholoogi seisukohavõtud laste õiguste kaitsjana ja koolihariduse uuendajana silma paistnud Kaur Hansoni pedofiiliasüüdistuste kohta

  10. Kultuur isiksuse psühholoogiat ei mõjuta / Tiit Kändler

    Index Scriptorium Estoniae

    Kändler, Tiit, 1948-

    2010-01-01

    Psühholoogia uuemate andmete kohaselt ei sõltu indiviidi seadumus kultuurist, soost, vanusest, haridusest. Eesti psühholoogide Jüri Alliku ja Ann Realo osalusel ajakirjas "Journal Personality and Social Psychology" ilmunud artiklist

  11. Kultuur isiksuse psühholoogiat ei mõjuta / Tiit Kändler

    Index Scriptorium Estoniae

    Kändler, Tiit, 1948-

    2005-01-01

    Psühholoogia uuemate andmete kohaselt ei sõltu indiviidi seadumus kultuurist, soost, vanusest, haridusest. Eesti psühholoogide Jüri Alliku ja Anu Realo osalusel ajakirjas "Journal Personality and Social Psychology" ilmunud artiklist

  12. Comparative, validity and responsiveness of the HOOS-PS and KOOS-PS to the WOMAC physical function subscale in total joint replacement for osteoarthritis

    DEFF Research Database (Denmark)

    Davis, A M; Perruccio, A V; Canizares, M

    2009-01-01

    OBJECTIVE: To evaluate the internal consistency of the Hip disability and Osteoarthritis Outcome Score-Physical Function Short-form (HOOS-PS) and the Knee injury and Osteoarthritis Outcome Score-Physical Function Short-form (KOOS-PS) in total hip replacement (THR) and total knee (TKR) replacement....... Construct validity and responsiveness were compared to the Western Ontario McMaster Universities' Osteoarthritis Index (WOMAC) Likert 3.0 physical function (PF) subscale and the PF excluding the items in the short measures (PF-exclusions). METHODS: Participants completed the full HOOS or KOOS, measures...... of fatigue, anxiety, depression and the Chronic Pain Grade (CPG) pre-surgery and the HOOS or KOOS 6 months post-surgery. Internal consistency for the HOOS-PS and KOOS-PS was calculated using Cronbach's alpha. For construct validity, it was hypothesized that correlations between the HOOS-PS or KOOS-PS and PF...

  13. Analüütilised voolud psühholoogias ja nende rakendamine pedagoogikas / Aleksander Elango

    Index Scriptorium Estoniae

    Elango, Aleksander, 1902-2004

    2001-01-01

    Analüütise psühholoogia kolm koolkonda - S.Freudì koolkond e. päris-psühhoanalüüs, A.Adlerì koolkond e. individuaalpsühholoogia ja C.G.Jungì psühhoanalüüsi ja individuaalpsühholoogia sünteesi luua püüdev koolkond. Analüütise psühholoogia koolkondade ja pedagoogika suhetest

  14. File list: His.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.10.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX110016,S...315,SRX381309 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.10.AllAg.iPS_cells.bed ...

  15. File list: ALL.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.50.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9773...1,SRX035985,SRX1090869 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.50.AllAg.iPS_cells.bed ...

  16. File list: ALL.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.50.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX088...16,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.50.AllAg.iPS_cells.bed ...

  17. File list: ALL.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.20.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX088...27,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.20.AllAg.iPS_cells.bed ...

  18. File list: DNS.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.50.AllAg.iPS_cells hg19 DNase-seq Pluripotent stem cell iPS cells SRX040379...,SRX040378,SRX135563,SRX040376,SRX040377,SRX189427,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.50.AllAg.iPS_cells.bed ...

  19. File list: His.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.05.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX317576,S...077,SRX317607 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.05.AllAg.iPS_cells.bed ...

  20. File list: Oth.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.AllAg.iPS_cells mm9 TFs and others Pluripotent stem cell iPS cells SRX65...RX146524 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.AllAg.iPS_cells.bed ...

  1. File list: ALL.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.20.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9773...30,SRX146522,SRX146547 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.20.AllAg.iPS_cells.bed ...

  2. File list: His.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX110015,S...315,SRX381309 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.20.AllAg.iPS_cells.bed ...

  3. File list: His.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.50.AllAg.iPS_cells mm9 Histone Pluripotent stem cell iPS cells SRX977417,SR...RX127376,SRX146530,SRX146522,SRX146547,SRX333561,SRX035985,SRX1090869 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.50.AllAg.iPS_cells.bed ...

  4. File list: Pol.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.05.AllAg.iPS_cells mm9 RNA polymerase Pluripotent stem cell iPS cells SRX97...7435,SRX027462,SRX977434 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.05.AllAg.iPS_cells.bed ...

  5. File list: ALL.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.10.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9774...30,SRX146524,SRX146547,SRX146522 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.10.AllAg.iPS_cells.bed ...

  6. PsHint1, associated with the G-protein α subunit PsGPA1, is required for the chemotaxis and pathogenicity of Phytophthora sojae.

    Science.gov (United States)

    Zhang, Xin; Zhai, Chunhua; Hua, Chenlei; Qiu, Min; Hao, Yujuan; Nie, Pingping; Ye, Wenwu; Wang, Yuanchao

    2016-02-01

    Zoospore chemotaxis to soybean isoflavones is essential in the early stages of infection by the oomycete pathogen Phytophthora sojae. Previously, we have identified a G-protein α subunit encoded by PsGPA1 which regulates the chemotaxis and pathogenicity of P. sojae. In the present study, we used affinity purification to identify PsGPA1-interacting proteins, including PsHint1, a histidine triad (HIT) domain-containing protein orthologous to human HIT nucleotide-binding protein 1 (HINT1). PsHint1 interacted with both the guanosine triphosphate (GTP)- and guanosine diphosphate (GDP)-bound forms of PsGPA1. An analysis of the gene-silenced transformants revealed that PsHint1 was involved in the chemotropic response of zoospores to the isoflavone daidzein. During interaction with a susceptible soybean cultivar, PsHint1-silenced transformants displayed significantly reduced infectious hyphal extension and caused a strong cell death in plants. In addition, the transformants displayed defective cyst germination, forming abnormal germ tubes that were highly branched and exhibited apical swelling. These results suggest that PsHint1 not only regulates chemotaxis by interacting with PsGPA1, but also participates in a Gα-independent pathway involved in the pathogenicity of P. sojae. © 2015 BSPP AND JOHN WILEY & SONS LTD.

  7. A LVDT conditioner for the beam profile monitors of the AmPS

    International Nuclear Information System (INIS)

    Es, J.T. van; Trigt, J.H. van.

    1991-01-01

    A LVDT (Linear Variable Differential Transformer) is a transducer for localization. Because of its applied materials, its construction and the absence of bearings etc. the instrument is suitable to be applied in locations where radioactive radiation is present. In order to obtain information about the position of the iron core in the transducer, a conditioner is needed. In 1977 by Digel a conditioner has been developed for the beam profile monitors (moving wire) of MEA because the 'market' could not meet the requirements then. Nowadays the 'market' offers i.c.'s which can take over the work of the Eurocard developed then. Digel has investigated them in order to see if they are applicable for the beam profile monitors of AmPS. (author). 5 refs.; 7 figs.; 13 tabs

  8. Study on thermal, mechanical and adsorption properties of amine-functionalized MCM-41/PMMA and MCM-41/PS nanocomposites prepared by ultrasonic irradiation.

    Science.gov (United States)

    Mohammadnezhad, Gholamhossein; Abad, Saeed; Soltani, Roozbeh; Dinari, Mohammad

    2017-11-01

    In this study, two common industrial polymers, poly(methyl methacrylate) (PMMA) and polystyrene (PS), were incorporated into amine-functionalized MCM-41 mesoporous silica as reinforcement agents via an ultrasonic assisted method as a facile, fast, eco-friendly, and versatile synthetic tool. Amino functionalization of MCM-41 were performed by 3-aminopropyl triethoxysilane as a coupling agent and it is denoted as APTS-MCM-41. The obtained nanocomposites (NCs), APTS-MCM-41/PMMA and APTS-MCM-41/PS, were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning and transmission electron microscopies (SEM and TEM), and thermogravimetric analysis (TGA). Their mechanical properties were also probed via stress-strain curves and improved tensile properties were observed in the NCs relative to the neat polymers. Additionally, APTS-MCM-41/PMMA exhibited better mechanical properties than APTS-MCM-41/PS. Sorption studies were carried out on the two NCs and the effect of different process parameters, namely, pH, contact time, and initial Cd(II) concentration investigated in batch mode. Pseudo-second order and intraparticle diffusion models explain the Cd(II) kinetics more effectively for APTS-MCM-41/PMMA and APTS-MCM-41/PS, respectively. The adsorption isotherm data fitted well to Langmuir isotherm for both NCs and the maximum monolayer adsorption capacities were found to be 24.75mg/g and 10.42mg/g for APTS-MCM-41/PMMA and APTS-MCM-41/PS, respectively. The results demonstrate that the NCs show potential for use in adsorption of heavy metal ion such as Cd(II) from aqueous media. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Dynamic radio bursts associated with important flare activity in Hale region 16923 and the problem of the relative locations of type II 'slow drift' bursts and coronal transients

    Energy Technology Data Exchange (ETDEWEB)

    Mckenna-Lawlor, S.M.P.

    1983-03-01

    Seven type-II radio bursts associated with solar flares in the Hale region 16923 on June 27-29, 1980, are characterized on the basis of data from dynamic radio spectra, white-light observations, radioheliograms, SMM-C/P observations, and Helios I magnetic-field and solar-wind measurements. The data are summarized in tables and graphs and discussed in terms of transient events occurring in the same region. The magnetic shock waves recorded during the period by Helios are described, and channeling effects which may have prevented the detection of type-II burst shocks are examined.

  10. Beam Quality Preservation in the CERN PS-SPS Complex

    CERN Multimedia

    Arduini, Gianluigi

    2004-01-01

    The LHC will require beams of unprecedented transverse and longitudinal brightness. Their production imposes tight constraints on the emittance growth in each element of the LHC injector chain, namely the PS-SPS Accelerator Complex. The problems encountered at the different stages of the acceleration in the complex span a wide range of topics, such as injection matching, RF gymnastics, space charge, transverse and longitudinal single- and coupled-bunch instabilities, and electron cloud effects. The measurement techniques developed and applied to identify and study the various sources of emittance dilution to the high precision required for the LHC beams and the solutions found to control such phenomena are illustrated.

  11. Injection and transfer lines of the PS Booster

    CERN Multimedia

    Photographic Service

    1972-01-01

    In the foreground is the vacuum chamber for the 50 MeV proton beam coming from the Linac. The tank held by white frames houses the "Vertical Distributor", which deflects the Linac beam to the levels of the Booster's 4 superposed rings. After acceleration in the Booster, originally to 800 MeV, today to 1.4 GeV, the beams from the 4 rings are combined in the vertical plane and transfered to the 26 GeV PS. The "Recombination Line", intersecting the injection line, crosses the picture from left to right.

  12. Stellarator fields with small PS current at small rotational transform

    International Nuclear Information System (INIS)

    Herrnegger, F.

    2001-01-01

    One aspect of the optimization concept of stellarators is the reduction of the normalized Pfirsch-Schlueter current density p arallel 2 / j p erpendikular 2 > 1/2 to a reasonable level but obeying other side conditions, e.g., concerning small bootstrap currents, good stability properties, reasonable aspect ratio, etc. This problem is addressed in the present work. Various stellarator vacuum field are given analytically for M 2, 3, 5, 10, 12 (M is the number of field period around the torus) where the PS-current density is reduced by more than a factor of ten to rather small values around 0.3 even at small i-values

  13. Lo irreductible social y lo irreductible psíquico

    Directory of Open Access Journals (Sweden)

    Vincent Gaulejac, de

    2017-06-01

    Full Text Available Con base en la reconstrucción de las polaridades explicativas -lo irreductible social y lo irreductible psíquico-que atraviesan a las ciencias sociales, este texto propone trascender los modelos antagónicos y excluyentes. El objetivo es instaurar en el centro de la reflexión la idea de la dialktica existencial que restituye al sujeto tanto el contexto socio-histórico en el cual está localizado como el deseo y la singularidad que lo constituyen en productor de la afirmación de su individualidad y su historicidad.

  14. Radiation improvement of PS/LDPE blends with SBS compatibilizer

    International Nuclear Information System (INIS)

    Chaisupakitsin, M.; Suwanapayom, S.

    2000-01-01

    Mechanical properties of PS(polystyrene)/LDPE(low density polyethylene) blends with and without SBS compatibilizer were investigated after γ-irradiation at dose range of 10-240 kGy under air atmospheric pressure. It was found that elongation at break and impact strength of the blends were mainly depended on the amount of the compatibilizer. On the other hand, tensile strength was improved by γ-irradiation, particularly, at dose range of 40-180 kGy. Gel fraction was found to increased with increasing compatibilizer and irradiation dose. (author)

  15. Electrostatic septum for "Continuous Transfer" from PS to SPS

    CERN Multimedia

    CERN PhotoLab

    1982-01-01

    For "Continuous Transfer" to the SPS, the PS beam, after acceleration, is peeled off in 5 turns. To minimize losses, the magnetic septa are preceded by an electrostatic septum in straight section 31. We see the inner part of it, on a lab-bench. The first part consists of W-wires, the second part is a Mo-foil. The circulating beam passes through the opening, the ejected beam at the outside (above the wires, in this picture). This assembly is the anode-part, the cathode is not shown.

  16. Possibility of a higher PSB to PS transfer energy

    CERN Document Server

    Hanke, K; Blas, A; Borburgh, J; Bozzini, D; Buzio, M; Capatina, O; Carli, C; Dobers, T; Fernandez, L; Findlay, A; Folch, R; Gilardoni, S; Gilbert, N; Hermanns, T; Mahner, E; Mikulec, B; Newborough, A; Nonis, M; Olek, S; Paoluzzi, M; Pittet, S; Ruehl, I; Rumolo, G; Steerenberg, R; Tan, J; Tommasini, D; Weterings, W; Widorski, M; Shaposhnikova, E

    2011-01-01

    Following the Chamonix 2010 workshop a task force has been set up to study the feasibility and the impact of an energy upgrade of the PS Booster from the present 1.4 GeV to about 2 GeV. The working group has confirmed the feasibility of such an upgrade, and analysed in detail the impact on the accelerator hardware along with a cost estimate and a tentative planning. The outcome of the task force will be summarized, with particular emphasis on the remaining limitations, risks and uncertainties.

  17. Status of the Upgrade of the CERN PS Booster

    CERN Document Server

    Hanke, K; Angoletta, M; Bartmann, W; Bartolome, S; Benedetto, E; Bertone, C; Blas, A; Bonnal, P; Borburgh, J; Bozzini, D; Butterworth, A; Carli, C; Carlier, E; Cole, J; Dahlen, P; Delonca, M; Dobers, T; Findlay, A; Froeschl, R; Hansen, J; Hay, D; Jensen, S; Lacroix, J; Le Roux, P; Lopez Hernandez, L; Maglioni, C; Masi, A; Mason, G; Mathot, S; Mikulec, B; Muttoni, Y; Newborough, A; Nisbet, D; Olek, S; Paoluzzi, M; Perillo-Marcone, A; Pittet, S; Puccio, B; Raginel, V; Riffaud, B; Ruehl, I; Sarrió Martínez, A; Tan, J; Todd, B; Venturi, V; Weterings, W

    2013-01-01

    The CERN PS Booster (PSB) is presently undergoing an ambitious consolidation and upgrade program within the frame of the LHC Injectors Upgrade (LIU) project. This program comprises a new injection scheme for H- ions from CERN’s new Linac4, the replacement of the main RF systems and an energy upgrade of the PSB rings from 1.4 to 2 GeV which includes the replacement of the main magnet power supply as well as the upgrade of the extraction equipment. This paper describes the status and plans of this work program.

  18. Methods for obtention of PS/clay nanocomposites

    International Nuclear Information System (INIS)

    Lins, Pedro G.; Valera, Ticiane S.; Coelho, Caio P.D.; Demarquette, Nicole R.

    2009-01-01

    In this work, nanocomposites of Polystyrene (PS) and organoclay were obtained using a twin-screw extruder and a mixer Haake. A commercial clay named Cloisite 20A was used. The clay and the nanocomposites were characterized by X-Ray Diffraction. The rheological properties were investigated carrying out small amplitude oscillatory strain (SAOS). The results of X-ray diffraction showed that the polymer was incorporated by the organoclay. The results of SAOS indicated a better clay dispersion for the samples obtained using the mixer. (author)

  19. Search for Decays of Heavy Neutrinos with the PS Beam

    CERN Multimedia

    2002-01-01

    The experiment searches for neutrino decay, primarily into the e|+e|-@n^e and @g@g@n^e modes. Neutrino masses in the region between 1 and 400~MeV will be explored. The beam used is the neutrino PS beam used for the oscillation experiments. The apparatus consists of a decay volume @=30~m long and a calorimeter @=8~radiation lengths thick and @=20~m|2 in surface. The detectors are flash-tube modules of the type developed at Saclay for the proton-stability experiment. Scintillator hodoscopes give the timing information necessary for the trigger logic and background rejection.

  20. Onderzoek Location Based Marketing: Mobile = location = effect

    NARCIS (Netherlands)

    Gisbergen, M.S. van; Huhn, A.E.; Khan, V.J.; Ketelaar, P.E.

    2011-01-01

    Onderzoekers van de NHTV (Internationaa Hoger Onderwijs Breda, Radboud Universiteit, DVJ Insights en Popai Benelux lieten consumenten in een virtuele supermarkt advertenties via de smartphone ontvangen wanneer men langs het geadverteerde product liep. De uitkomsten laten zien dat 'location based

  1. Photosystem I shows a higher tolerance to sorbitol-induced osmotic stress than photosystem II in the intertidal macro-algae Ulva prolifera (Chlorophyta).

    Science.gov (United States)

    Gao, Shan; Zheng, Zhenbing; Gu, Wenhui; Xie, Xiujun; Huan, Li; Pan, Guanghua; Wang, Guangce

    2014-10-01

    The photosynthetic performance of the desiccation-tolerant, intertidal macro-algae Ulva prolifera was significantly affected by sorbitol-induced osmotic stress. Our results showed that photosynthetic activity decreased significantly with increases in sorbitol concentration. Although the partial activity of both photosystem I (PS I) and photosystem II (PS II) was able to recover after 30 min of rehydration, the activity of PS II decreased more rapidly than PS I. At 4 M sorbitol concentration, the activity of PS II was almost 0 while that of PS I was still at about one third of normal levels. Following prolonged treatment with 1 and 2 M sorbitol, the activity of PS I and PS II decreased slowly, suggesting that the effects of moderate concentrations of sorbitol on PS I and PS II were gradual. Interestingly, an increase in non-photochemical quenching occurred under these conditions in response to moderate osmotic stress, whereas it declined significantly under severe osmotic stress. These results suggest that photoprotection in U. prolifera could also be induced by moderate osmotic stress. In addition, the oxidation of PS I was significantly affected by osmotic stress. P700(+) in the thalli treated with high concentrations of sorbitol could still be reduced, as PS II was inhibited by 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU), but it could not be fully oxidized. This observation may be caused by the higher quantum yield of non-photochemical energy dissipation in PS I due to acceptor-side limitation (Y(NA)) during rehydration in seawater containing DCMU. © 2014 Scandinavian Plant Physiology Society.

  2. RAId_aPS: MS/MS analysis with multiple scoring functions and spectrum-specific statistics.

    Science.gov (United States)

    Alves, Gelio; Ogurtsov, Aleksey Y; Yu, Yi-Kuo

    2010-11-16

    Statistically meaningful comparison/combination of peptide identification results from various search methods is impeded by the lack of a universal statistical standard. Providing an E-value calibration protocol, we demonstrated earlier the feasibility of translating either the score or heuristic E-value reported by any method into the textbook-defined E-value, which may serve as the universal statistical standard. This protocol, although robust, may lose spectrum-specific statistics and might require a new calibration when changes in experimental setup occur. To mitigate these issues, we developed a new MS/MS search tool, RAId_aPS, that is able to provide spectrum-specific-values for additive scoring functions. Given a selection of scoring functions out of RAId score, K-score, Hyperscore and XCorr, RAId_aPS generates the corresponding score histograms of all possible peptides using dynamic programming. Using these score histograms to assign E-values enables a calibration-free protocol for accurate significance assignment for each scoring function. RAId_aPS features four different modes: (i) compute the total number of possible peptides for a given molecular mass range, (ii) generate the score histogram given a MS/MS spectrum and a scoring function, (iii) reassign E-values for a list of candidate peptides given a MS/MS spectrum and the scoring functions chosen, and (iv) perform database searches using selected scoring functions. In modes (iii) and (iv), RAId_aPS is also capable of combining results from different scoring functions using spectrum-specific statistics. The web link is http://www.ncbi.nlm.nih.gov/CBBresearch/Yu/raid_aps/index.html. Relevant binaries for Linux, Windows, and Mac OS X are available from the same page.

  3. Two-year survival rates of anti-TNF-α therapy in psoriatic arthritis (PsA) patients with either polyarticular or oligoarticular PsA.

    Science.gov (United States)

    Iannone, F; Lopriore, S; Bucci, R; Scioscia, C; Anelli, M G; Notarnicola, A; Lapadula, G

    2015-05-01

    To evaluate the 2-year drug survival rates of the tumour necrosis factor (TNF)-α blockers adalimumab, etanercept, and infliximab in psoriatic arthritis (PsA) patients with either oligoarticular (oligo-PsA) or polyarticular PsA (poly-PsA). We studied a prospective cohort of 328 PsA patients with peripheral arthritis (213 with poly-PsA and 115 with oligo-PsA), beginning their first ever anti-TNF-α treatment with adalimumab, etanercept, or infliximab. The aim of the study was to evaluate the drug survival rates and possible baseline predictors at 2 years. After 24 months, persistence in therapy with the first anti-TNF-α blocker was not statistically different in the oligo-PsA (70.4%) and poly-PsA (65.7%) subsets. Predictors of drug discontinuation were female sex [hazard ratio (HR) 1.63, 95% confidence interval (CI) 1.00-2.68, p = 0.04] and starting the therapy in years 2003-8 (HR 0.51, 95% CI 0.33-0.80, p = 0.003). In poly-PsA, the persistence of etanercept (68.3%) was significantly higher than that of adalimumab (51.9%, p = 0.01), whereas in oligo-PsA no significant difference was detected. In poly-PsA, the period 2003-8 was a negative predictor (HR 0.36, 95% CI 0.21-0.62, p = 0.0001) whereas in oligo-PsA female gender was a positive predictor of drug discontinuation (HR 2.08, 95% CI 1.02-4.24, p = 0.04). With regard to clinical outcomes, the best responses in terms of European League Against Rheumatism (EULAR) 'good' response or Disease Activity Score (DAS28) remission, crude or adjusted according to the LUND Efficacy indeX (LUNDEX), were seen in patients on etanercept or infliximab. Our study provides some evidence that anti-TNF-α drugs may perform differently in PsA, and that the analysis of clinical disease subsets may improve our knowledge and promote better management of PsA.

  4. cobalt (ii), nickel (ii)

    African Journals Online (AJOL)

    DR. AMINU

    Department of Chemistry Bayero University, P. M. B. 3011, Kano, Nigeria. E-mail: hnuhu2000@yahoo.com. ABSTRACT. The manganese (II), cobalt (II), nickel (II) and .... water and common organic solvents, but are readily soluble in acetone. The molar conductance measurement [Table 3] of the complex compounds in.

  5. Jagiellonian University Advances in Ps Manipulations and Laser Studies in the AEgIS Experiment

    CERN Document Server

    Caravita, R; Amsler, C; Bonomi, G; Brusa, R S; Caccia, M; Castelli, F; Cerchiari, G; Comparat, D; Consolati, G; Demetrio, A; Di Noto, L; Doser, M; Evans, C; Ferragut, R; Fesel, J; Fontana, A; Gerber, S; Giammarchi, M; Gligorova, A; Guatieri, F; Haider, S; Hinterberger, A; Holmestad, H; Kellerbauer, A; Khalidova, O; Krasnický, D; Lagomarsino, V; Lansonneur, P; Lebrun, P; Malbrunot, C; Mariazzi, S; Marton, J; Matveev, V; Mazzotta, Z; Müller, S R; Nebbia, G; Nedelec, P; Oberthaler, M; Pacifico, N; Pagano, D; Penasa, L; Petracek, V; Prelz, F; Prevedelli, M; Ravelli, L; Rienäcker, B; Robert, J; Røhne, O M; Rotondi, A; Sandaker, H; Santoro, R; Smestad, L; Sorrentino, F; Testera, G; Tietje, I; Widmann, E; Yzombard, P; Zimmer, C; Zmeskal, J; Zurlo, N

    2017-01-01

    Positronium (Ps), the unstable bound state of electron and positron, is a valuable system for neutral antimatter spectroscopic studies and for antihydrogen production. Forming a pulsed beam cold antihydrogen using charge-exchange with the Rydberg Ps is the goal of the AEgIS Collaboration, which aims to measure gravity on neutral antimatter. Recent results achieved in producing, manipulating and studying Ps are summarized. Ps has been first produced with mesoporous silica targets in a reflection geometry. Spectroscopy of Ps n = 3 state has been conducted, yielding as a byproduct an independent estimate of the produced Ps temperature. Efficient laser excitation to the Rydberg levels was then achieved, validating the proof-of-concept of AEgIS. Subsequently, production of Ps from a new class of transmission targets was also achieved, opening the possibility for future experiments.

  6. Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution.

    Science.gov (United States)

    Sun, Zhenzhen; Xie, Yujie; Chen, Yintong; Yang, Qinghu; Quan, Zhenzhen; Dai, Rongji; Qing, Hong

    2018-05-01

    γ-Secretase has been a therapeutical target for its key role in cleaving APP to generate β-amyloid (Aβ), the primary constituents of senile plaques and a hallmark of Alzheimer's disease (AD) pathology. Recently, γ-secretase-associating proteins showed promising role in specifically modulating APP processing while sparing Notch signaling; however, the underlying mechanism is still unclear. A co-immunoprecipitation (Co-IP) coupled with mass spectrometry proteomic assay for Presenilin1 (PS1, the catalytic subunit of γ-secretase) was firstly conducted to find more γ-secretase-associating proteins. Gene ontology analysis of these results identified Rab21 as a potential PS1 interacting protein, and the interaction between them was validated by reciprocal Co-IP and immunofluorescence assay. Then, molecular and biochemical methods were used to investigate the effect of Rab21 on APP processing. Results showed that overexpression of Rab21 enhanced Aβ generation, while silencing of Rab21 reduced the accumulation of Aβ, which resulted due to change in γ-secretase activity rather than α- or β-secretase. Finally, we demonstrated that Rab21 had no effect on γ-secretase complex synthesis or metabolism but enhanced PS1 endocytosis and translocation to late endosome/lysosome. In conclusion, we identified a novel γ-secretase-associating protein Rab21 and illustrate that Rab21 promotes γ-secretase internalization and translocation to late endosome/lysosome. Moreover, silencing of Rab21 decreases the γ-secretase activity in APP processing thus production of Aβ. All these results open new gateways towards the understanding of γ-secretase-associating proteins in APP processing and make inhibition of Rab21 a promising strategy for AD therapy.

  7. Preparations for Upgrading the RF Systems of the PS Booster

    CERN Document Server

    Albright, Simon; Shaposhnikova, Elena

    2016-01-01

    The accelerators of the LHC injector chain need to be upgraded to provide the HL-LHC beams. The PS Booster, the first synchrotron in the LHC injection chain, uses three different RF systems (first, second and up to tenth harmonic) in each of its four rings. As part of the LHC Injector Upgrade the current ferrite RF systems will be replaced with broadband Finemet cavities, increasing the flexibility of the RF system. A Finemet test cavity has been installed in Ring 4 to investigate its effect on machine performance, especially beam stability, during extensive experimental studies. Due to large space charge impedance Landau damping is lost through most of the cycle in single harmonic operation, but is recovered when using the second harmonic and controlled longitudinal emittance blow-up. This paper compares beam parameters during acceleration with and without the Finemet test cavity. Comparisons were made using beam measurements and simulations with the BLonD code based on a full PS Booster impedance model. Thi...

  8. Electron cloud in the CERN accelerators (PS, SPS, LHC)

    International Nuclear Information System (INIS)

    Iadarola, G; Rumolo, G

    2013-01-01

    Several indicators have pointed to the presence of an Electron Cloud (EC) in some of the CERN accelerators, when operating with closely spaced bunched beams. In particular, spurious signals on the pick ups used for beam detection, pressure rise and beam instabilities were observed at the Proton Synchrotron (PS) during the last stage of preparation of the beams for the Large Hadron Collider (LHC), as well as at the Super Proton Synchrotron (SPS). Since the LHC has started operation in 2009, typical electron cloud phenomena have appeared also in this machine, when running with trains of closely packed bunches (i.e. with spacings below 150ns). Beside the above mentioned indicators, other typical signatures were seen in this machine (due to its operation mode and/or more refined detection possibilities), like heat load in the cold dipoles, bunch dependent emittance growth and degraded lifetime in store and bunch-by-bunch stable phase shift to compensate for the energy loss due to the electron cloud. An overview of the electron cloud status in the different CERN machines (PS, SPS, LHC) will be presented in this paper, with a special emphasis on the dangers for future operation with more intense beams and the necessary countermeasures to mitigate or suppress the effect. (author)

  9. Electrohydraulic drive system with planetary superposed PS 16 gears

    Energy Technology Data Exchange (ETDEWEB)

    Graetz, A.; Klimek, K.H.; Welz, H.

    1988-10-20

    During the nine-month period of use of the electrohydraulic drive system with PS 16 superposed planetary gear and hydrostatic support advance of 800 m was achieved on the 250 m long face in the Geitling 2 seam at the Niederberg colliery. No appreciable difficulties occurred in the hydraulic system and with the PS 16 superposed planetary gear in the entire period. Uniform load distribution between the two drives was proved until the end of the working even with a chain elongation difference up to 3% observed during the final phase of operation. In contrast to normal operation thermal disconnections and motor failures no longer occurred. After accurate adjustment of the pressures the system operated successfully. The time utilisation of the equipment was improved by 15% to 65.7%. The quick and reliable response of the hydraulics in the event of overloading ensured that no chain cracks occurred. The four connector fractures were attributable to fatigue failures. The material-protecting method of operation was proved by the quiet running of the chain and substantially longer operating time, e.g. of the chain and sprocket. To prove the efficiency of the new drive system, comprehensive measurements were undertaken. It emerged during these measurements that in contrast to the conventional drives the load equalisation ensures that the total installed power is available if required. However, the freeing capacity of the plough could not be fully utilised because of the missing conveyor cross-section.

  10. Linac4, a New Injector for the CERN PS Booster

    CERN Document Server

    Garoby, R; Gerigk, F; Hanke, K; Lombardi, A; Pasini, M; Rossi, C; Sargsyan, E; Vretenar, M

    2006-01-01

    The first bottle-neck towards higher beam brightness in the LHC injector chain is due to space charge induced tune spread at injection into the CERN PS Booster (PSB). A new injector called Linac4 is proposed to remove this limitation. Using RF cavities at 352 and 704 MHz, it will replace the present 50 MeV proton Linac2, and deliver a 160 MeV, 40 mA H- beam. The higher injection energy will reduce space charge effects by a factor of 2, and charge exchange will drastically reduce the beam losses at injection. Operation will be simplified and the beam brightness required for the LHC ultimate luminosity should be obtained at PS ejection. Moreover, for the needs of non-LHC physics experiments like ISOLDE, the number of protons per pulse from the PSB will increase by a significant factor. This new linac constitutes an essential component of any of the envisaged LHC upgrade scenarios. It is also designed to become the low energy part of a future 3.5 GeV, multi-megawatt superconducting linac (SPL). The present desig...

  11. Broadband and short (10-ps) pulse generation on Nova

    International Nuclear Information System (INIS)

    Perry, M.D.; Browning, D.; Bibeau, C.; Patterson, F.G.; Wilcox, R.; Henesian, M.

    1990-01-01

    The ability to produce high power broadband pulses for purposes of focal spot beam smoothing has recently become an important issue in inertial confinement fusion (ICF). As the first step toward the generation and propagation of such pulses on Nova, the authors have performed a series of experiments with 10-ps pulses. Aside from the inherently broad bandwidth, these short pulses have important applications in ICF experiments and x-ray laser research. The author's experimental results are discussed. The short pulses were produced by diffraction grating pulse compression of chirped pulses formed from self-phase modulation in a single-mode 10-m fused silica fiber. Use of such a short fiber produces a nonlinearly chirped spectrum of 0.74 nm. The central nearly linearly chirped 0.26 nm is selected by polarization discrimination and compressed using 1800-line/mm diffraction gratings to a nearly Gaussian pulse of 10 ps FWHM with an energy contrast ratio of 20:1. This 1-nJ pulse is injected into a Nova amplifier chain with selected amplifiers unfired

  12. Modulation of photosystem II chlorophyll fluorescence by electrogenic events generated by photosystem I

    NARCIS (Netherlands)

    Bulychev, A.A.; Vredenberg, W.J.

    2001-01-01

    In an attempt to uncover electric field interactions between PS I and PS II during their functioning, fluorescence induction curves were measured on hydroxylamine-treated thylakoids of Chenopodium album under conditions ensuring low and high levels of photogenerated membrane potentials. In parallel

  13. Leo II PC

    Data.gov (United States)

    Kansas Data Access and Support Center — LEO II is a second-generation software system developed for use on the PC, which is designed to convert location references accurately between legal descriptions and...

  14. PS1-10bzj: A FAST, HYDROGEN-POOR SUPERLUMINOUS SUPERNOVA IN A METAL-POOR HOST GALAXY

    Energy Technology Data Exchange (ETDEWEB)

    Lunnan, R.; Chornock, R.; Berger, E.; Milisavljevic, D.; Drout, M.; Sanders, N. E.; Challis, P. M.; Czekala, I.; Foley, R. J.; Fong, W.; Kirshner, R. P.; Leibler, C.; Marion, G. H.; Narayan, G. [Harvard-Smithsonian Center for Astrophysics, 60 Garden St., Cambridge, MA 02138 (United States); Huber, M. E. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); McCrum, M.; Smartt, S. J. [Astrophysics Research Centre, School of Mathematics and Physics, Queen' s University Belfast, Belfast BT7 1NN (United Kingdom); Rest, A. [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States); Roth, K. C. [Gemini Observatory, 670 N. Aohoku Place, Hilo, HI 96720 (United States); Scolnic, D., E-mail: rlunnan@cfa.harvard.edu [Department of Physics and Astronomy, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); and others

    2013-07-10

    We present observations and analysis of PS1-10bzj, a superluminous supernova (SLSN) discovered in the Pan-STARRS Medium Deep Survey at a redshift z = 0.650. Spectroscopically, PS1-10bzj is similar to the hydrogen-poor SLSNe 2005ap and SCP 06F6, though with a steeper rise and lower peak luminosity (M{sub bol} {approx_equal} -21.4 mag) than previous events. We construct a bolometric light curve, and show that while PS1-10bzj's energetics were less extreme than previous events, its luminosity still cannot be explained by radioactive nickel decay alone. We explore both a magnetar spin-down and circumstellar interaction scenario and find that either can fit the data. PS1-10bzj is located in the Extended Chandra Deep Field South and the host galaxy is imaged in a number of surveys, including with the Hubble Space Telescope. The host is a compact dwarf galaxy (M{sub B} Almost-Equal-To -18 mag, diameter {approx}< 800 pc), with a low stellar mass (M{sub *} Almost-Equal-To 2.4 Multiplication-Sign 10{sup 7} M{sub Sun }), young stellar population ({tau}{sub *} Almost-Equal-To 5 Myr), and a star formation rate of {approx}2-3 M{sub Sun} yr{sup -1}. The specific star formation rate is the highest seen in an SLSN host so far ({approx}100 Gyr{sup -1}). We detect the [O III] {lambda}4363 line, and find a low metallicity: 12 + (O/H) = 7.8 {+-} 0.2 ({approx_equal} 0.1 Z{sub Sun }). Together, this indicates that at least some of the progenitors of SLSNe come from young, low-metallicity populations.

  15. Psychometric properties of the OARSI/OMERACT osteoarthritis pain and functional impairment scales: ICOAP, KOOS-PS and HOOS-PS.

    Science.gov (United States)

    Ruyssen-Witrand, A; Fernandez-Lopez, C J; Gossec, L; Anract, P; Courpied, J P; Dougados, M

    2011-01-01

    To evaluate the psychometric properties of the OARSI-OMERACT questionnaires in comparison to the existing validated scales. Consecutive hip or knee osteoarthritis patients consulting in an orthopedic department were enrolled in the study. Data collected were pain using the Intermittent and Constant Osteoarthritis Pain (ICOAP), a Numeric Rating Scale (NRS), the Western Ontario McMaster Universities' Osteoarthritis Index (WOMAC) pain subscale, the Lequesne pain subscale; functional impairment using the Knee disability and Osteoarthritis Outcome Score-Physical Function Shortform (KOOS-PS), the Hip disability and Osteoarthritis Outcome Score-Physical Function Shortform (HOOS-PS), a NRS, the WOMAC function sub-scale, the Lequesne function subscale. Validity was assessed by calculating the Spearman's correlation coefficient between all the scales. Reliability was assessed in out-patients with stable disease comparing the data collected within 2 weeks using the intra-class correlation coefficient (ICC). Responsiveness was assessed on the data from hospitalised patients prior to and 12 weeks after a total joint replacement (TJR) using the standardised response mean. Three hundred patients (mean age=68 years, females=62%, hip OA=57%) were included. There was a moderate to good correlation between ICOAP, KOOS-PS, HOOS-PS and the WOMAC, NRS and Lequesne scales. Reliability of the ICOAP hip OA HOOS-PS and KOOS-PS was good (ICC range 0.80-0.81) whereas it was moderate for knee ICOAP (ICC=0.65). Responsiveness of the ICOAP, KOOS-PS and HOOS-PS 12 weeks after TJR was comparable to responsiveness of other scales (SRM range: 0.54-1.82). The psychometric properties of the ICOAP, KOOS-PS and HOOS-PS were comparable to those of the WOMAC, Lequesne and NRS.

  16. Location | FNLCR Staging

    Science.gov (United States)

    The Frederick National Laboratory for Cancer Research campus is located 50 miles northwest of Washington, D.C., and 50 miles west of Baltimore, Maryland, in Frederick, Maryland. Satellite locations include leased and government facilities extending s

  17. Appraising manufacturing location

    NARCIS (Netherlands)

    Steenhuis, H.J.; de Bruijn, E.J.

    2002-01-01

    International location of manufacturing activities is an issue for managers of manufacturing companies as well as public policy makers. For managers, the issue is relevant because international locations offer opportunities for lowering costs due to productivity improvements. For governments the

  18. Law Enforcement Locations

    Data.gov (United States)

    Kansas Data Access and Support Center — Law Enforcement Locations in Kansas Any location where sworn officers of a law enforcement agency are regularly based or stationed. Law enforcement agencies "are...

  19. Live Life to the Power of PS2: Locating the Digital Games Industry in the New Media Environment

    OpenAIRE

    Kerr, Aphra

    2016-01-01

    The digital games industry is a global entertainment business stretching from Tokyo to San Francisco to London. In May each year, game developers from around the world meet in Los Angeles to pitch their ideas to publishers, sneak a preview of other games and do licensing deals with hardware companies and Hollywood studios. The show has much in common with Melia and Cannes: it has all the glitz, the hype and the stars. The main difference is that the stars are non-human, the digital game produ...

  20. GROUND SUBSIDENCE ALONG SHANGHAI METRO LINE 6 BY PS-InSAR METHOD

    Directory of Open Access Journals (Sweden)

    J. Wu

    2018-04-01

    Full Text Available With the rapid development of urban economy, convenient, safe, and efficient urban rail transit has become the preferred method for people to travel. In order to ensure the safety and sustainable development of urban rail transit, the PS-InSAR technology with millimeter deformation measurement accuracy has been widely applied to monitor the deformation of urban rail transit. In this paper, 32 scenes of COSMO-SkyMed descending images and 23 scenes of Envisat ASAR images covering the Shanghai Metro Line 6 acquired from 2008 to 2010 are used to estimate the average deformation rate along line-of-sight (LOS direction by PS-InSAR method. The experimental results show that there are two main subsidence areas along the Shanghai Metro Line 6, which are located between Wuzhou Avenue Station to Wulian Road Station and West Gaoke Road Station to Gaoqing Road Station. Between Wuzhou Avenue Station and Wulian Road Station, the maximum displacement rate in the vertical direction of COSMO-SkyMed images is −9.92 mm/year, and the maximum displacement rate in the vertical direction of Envisat ASAR images is −8.53 mm/year. From the West Gaoke Road Station to the Gaoqing Road Station, the maximum displacement rate in the vertical direction of COSMO-SkyMed images is −15.53 mm/year, and the maximum displacement rate in the vertical direction of Envisat ASAR images is −17.9 mm/year. The results show that the ground deformation rates obtained by two SAR platforms with different wavelengths, different sensors and different incident angles have good consistence with each other, and also that of spirit leveling.

  1. Germline competence of mouse ES and iPS cell lines: Chimera technologies and genetic background.

    Science.gov (United States)

    Carstea, Ana Claudia; Pirity, Melinda K; Dinnyes, Andras

    2009-12-31

    In mice, gene targeting by homologous recombination continues to play an essential role in the understanding of functional genomics. This strategy allows precise location of the site of transgene integration and is most commonly used to ablate gene expression ("knock-out"), or to introduce mutant or modified alleles at the locus of interest ("knock-in"). The efficacy of producing live, transgenic mice challenges our understanding of this complex process, and of the factors which influence germline competence of embryonic stem cell lines. Increasingly, evidence indicates that culture conditions and in vitro manipulation can affect the germline-competence of Embryonic Stem cell (ES cell) lines by accumulation of chromosome abnormalities and/or epigenetic alterations of the ES cell genome. The effectiveness of ES cell derivation is greatly strain-dependent and it may also influence the germline transmission capability. Recent technical improvements in the production of germline chimeras have been focused on means of generating ES cells lines with a higher germline potential. There are a number of options for generating chimeras from ES cells (ES chimera mice); however, each method has its advantages and disadvantages. Recent developments in induced pluripotent stem (iPS) cell technology have opened new avenues for generation of animals from genetically modified somatic cells by means of chimera technologies. The aim of this review is to give a brief account of how the factors mentioned above are influencing the germline transmission capacity and the developmental potential of mouse pluripotent stem cell lines. The most recent methods for generating specifically ES and iPS chimera mice, including the advantages and disadvantages of each method are also discussed.

  2. Smartphones as locative media

    CERN Document Server

    Frith, Jordan

    2015-01-01

    Smartphone adoption has surpassed 50% of the population in more than 15 countries, and there are now more than one million mobile applications people can download to their phones. Many of these applications take advantage of smartphones as locative media, which is what allows smartphones to be located in physical space. Applications that take advantage of people's location are called location-based services, and they are the focus of this book. Smartphones as locative media raise important questions about how we understand the complicated relationship between the Internet and physical space

  3. Sub-10ps monolithic and low-power photodetector readout

    International Nuclear Information System (INIS)

    Varner, Gary S.; Ruckman, Larry L.

    2009-01-01

    Recent advances in photon detectors have resulted in high-density imaging arrays that offer many performance and cost advantages. In particular, the excellent transit time spread of certain devices show promise to provide tangible benefits in applications such as Positron Emission Tomography (PET). Meanwhile, high-density, high-performance readout techniques have not kept on pace for exploiting these developments. Photodetector readout for next generation high event rate particle identification and time-resolved PET requires a highly-integrated, low-power, and cost-effective readout technique. We propose fast waveform sampling as a method that meets these criteria and demonstrate that sub-10ps resolution can be obtained for an existing device

  4. Multipole Stack for the 800 MeV PS Booster

    CERN Multimedia

    1975-01-01

    The 800 MeV PS Booster had seen first beam in its 4 superposed rings in 1972, routine operation began in 1973. In the strive for ever higher beam intensities, the need for additional multipole lenses became evident. After detailed studies, the manufacture of 8 stacks of multipoles was launched in 1974. Each stack consists of 4 superposed multipoles and each multipole has 4 concentric shells. From the innermost to the outermost shell, Type A contains octupole, skew-octupole, sextupole, skew-sextupole. Type B contains skew-octupole, skew-sextupole, vertical dipole, horizontal dipole. Completion of installation in 1976 opened the way to higher beam intensities. M. Battiaz is seen here with a multipole stack and its many electrical connections.

  5. Process equipment data organisation in CERN PS controls

    International Nuclear Information System (INIS)

    Casalegno, L.; Cuperus, J.; Sicard, C.H.

    1990-01-01

    The CERN PS control system has a widely distributed architecture, mainly for fast response in a real-time environment. The organisation of the data for equipment access must be compatible with this architecture and give efficient program access to the data. Moreover, it must also offer managerial features such as data integrity, easy backup and restoration, adaptibility to changes in data structure, initialisation, data-entry facilities and automatic documentation. This paper shows how one can take advantage of a commercial data-base management system with its associated tools, adding to it some object-oriented programming concepts to meet the objectives of a manageable distributed data organisation having good run-time performance features and using a reasonable manpower investment. (orig.)

  6. Electrodepositing of Au on hollow PS micro-spheres

    International Nuclear Information System (INIS)

    Sun Jingyuan; Zhang Yunwang; Du Kai; Wan Xiaobo; Xiao Jiang; Zhang Wei; Zhang Lin; Chen Jing

    2010-01-01

    Using the self-regulating new micro-sphere electrodepositing device, the techniques of electrodepositing gold on hollow PS micro-spheres were established. The experiment was carried out under the following conditions: voltage was about 0.7 ∼ 0.8 V, current density was 2.0 mA · cm -2 , the temperature was 45 degree C, cathode rotating rate was 250 r · min -1 , flow rate of the solution was 7 mL · min -1 · cm -2 . Hollow gold-plated micro-spheres were prepared with well spherical symmetry, uniform thickness and surface smoothness under 500 nm. The speed of the gold depositing was 6 μm · h -1 . (authors)

  7. A fit-based frequency programme for the PS

    CERN Document Server

    Hancock, S

    2007-01-01

    Since the probes in the PS reference magnet that generate the so-called B-train are fairly short, they cannot register any change in magnetic length due to saturation. Hence the idea to derive the effective dipole magnetic field seen by the beam from measurements of revolution frequency and mean radial position over an entire cycle, to fit a saturation law, and to use the result to make a new frequency programme. Although far from new, the idea has never been implemented due to the tacit assumption that any imperfections in the existing frequency programme are taken care of by the action of the servo loops of the various beam controls. More recently, the delivery of ions at low energy from LEIR has called into question the accuracy the raw frequency programme and the idea has been revisited in a brief parasitic MD.

  8. Sub-10ps monolithic and low-power photodetector readout

    Energy Technology Data Exchange (ETDEWEB)

    Varner, Gary S.; Ruckman, Larry L.

    2009-02-20

    Recent advances in photon detectors have resulted in high-density imaging arrays that offer many performance and cost advantages. In particular, the excellent transit time spread of certain devices show promise to provide tangible benefits in applications such as Positron Emission Tomography (PET). Meanwhile, high-density, high-performance readout techniques have not kept on pace for exploiting these developments. Photodetector readout for next generation high event rate particle identification and time-resolved PET requires a highly-integrated, low-power, and cost-effective readout technique. We propose fast waveform sampling as a method that meets these criteria and demonstrate that sub-10ps resolution can be obtained for an existing device.

  9. CERN's PS Booster LLRF renovation : plans and initial beam tests

    CERN Document Server

    Angoletta, ME; Butterworth, A; Findlay, A; Leinonen, PM; Molendijk, JC; Pedersen, F; Sanchez-Quesada, J; Schokker, M

    2010-01-01

    In 2008 a project was started to renovate the CERN's PS Booster (PSB) low-level RF (LLRF). Required LLRF capabilities include frequency program, beam phase, radial and synchronization loops. The new LLRF will control the signals feeding the three RF cavities present in each ring; it will also shape the beam in a dual harmonic mode, operate a bunch splitting and create a longitudinal blow-up. The main benefits of this new LLRF are its full remote and cycle-to-cycle controllability, built-in observation capability and flexibility. The overall aim is to improve the robustness, maintainability and reliability of the PSB operation and to make it compatible with the injection from the future Linac4. This paper outlines the main characteristics of the software and hardware building blocks. Initial beam test results and hints on the main milestones and future work are also given.

  10. OCT/PS-OCT imaging of brachial plexus neurovascular structures

    Science.gov (United States)

    Raphael, David T.; Zhang, Jun; Zhang, Yaoping; Chen, Zhongping; Miller, Carol; Zhou, Li

    2004-07-01

    Introduction: Optical coherence tomography (OCT) allows high-resolution imaging (less than 10 microns) of tissue structures. A pilot study with OCT and polarization-sensitive OCT (PS-OCT) was undertaken to image ex-vivo neurovascular structures (vessels, nerves) of the canine brachial plexus. Methods: OCT is an interferometry-based optical analog of B-mode ultrasound, which can image through non-transparent biological tissues. With approval of the USC Animal Care and Use Committee, segments of the supra- and infraclavicular brachial plexus were excised from euthanized adult dogs, and the ex-vivo specimens were placed in cold pH-buffered physiologic solution. An OCT beam, in micrometer translational steps, scanned the fixed-position bisected specimens in transverse and longitudinal views. Two-dimensional images were obtained from identified arteries and nerves, with specific sections of interest stained with hematoxylin-eosin for later imaging through a surgical microscope. Results: with the beam scan direction transverse to arteries, the resulting OCT images showed an identifiable arterial lumen and arterial wall tissue layers. By comparison, transverse beam OCT images of nerves revealed a multitude of smaller nerve bundles contained within larger circular-shaped fascicles. PS-OCT imaging was helpful in showing the characteristic birefringence exhibited by arrayed neural structures. Discussion: High-resolution OCT imaging may be useful in the optical identification of neurovascular structures during attempted regional nerve blockade. If incorporated into a needle-shaped catheter endoscope, such a technology could prevent intraneural and intravascular injections immediately prior to local anesthetic injection. The major limitation of OCT is that it can form a coherent image of tissue structures only to a depth of 1.5 - 2 mm.

  11. Updating the Psoriatic Arthritis (PsA) Core Domain Set: A Report from the PsA Workshop at OMERACT 2016.

    Science.gov (United States)

    Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J; Callis Duffin, Kristina; Elmamoun, Musaab; Tillett, William; Campbell, Willemina; FitzGerald, Oliver; Gladman, Dafna D; Goel, Niti; Gossec, Laure; Hoejgaard, Pil; Leung, Ying Ying; Lindsay, Chris; Strand, Vibeke; van der Heijde, Désirée M; Shea, Bev; Christensen, Robin; Coates, Laura; Eder, Lihi; McHugh, Neil; Kalyoncu, Umut; Steinkoenig, Ingrid; Ogdie, Alexis

    2017-10-01

    To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants. We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted 24 focus groups with 130 patients from 7 countries representing 5 continents to identify patient domains. We achieved consensus through 2 rounds of separate surveys with 50 patients and 75 physicians, and a nominal group technique meeting with 12 patients and 12 physicians. We conducted a workshop and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA Core Domain Set endorsed with 90% agreement by OMERACT 2016 participants included musculoskeletal disease activity, skin disease activity, fatigue, pain, patient's global assessment, physical function, health-related quality of life, and systemic inflammation, which were recommended for all RCT and LOS. These were important, but not required in all RCT and LOS: economic cost, emotional well-being, participation, and structural damage. Independence, sleep, stiffness, and treatment burden were on the research agenda. The updated PsA Core Domain Set was endorsed at OMERACT 2016. Next steps for the PsA working group include evaluation of PsA outcome measures and development of a PsA Core Outcome Measurement Set.

  12. PS-Modules over Ore Extensions and Skew Generalized Power Series Rings

    Directory of Open Access Journals (Sweden)

    Refaat M. Salem

    2015-01-01

    Full Text Available A right R-module MR is called a PS-module if its socle, SocMR, is projective. We investigate PS-modules over Ore extension and skew generalized power series extension. Let R be an associative ring with identity, MR a unitary right R-module, O=Rx;α,δ Ore extension, MxO a right O-module, S,≤ a strictly ordered additive monoid, ω:S→EndR a monoid homomorphism, A=RS,≤,ω the skew generalized power series ring, and BA=MS,≤RS,≤, ω the skew generalized power series module. Then, under some certain conditions, we prove the following: (1 If MR is a right PS-module, then MxO is a right PS-module. (2 If MR is a right PS-module, then BA is a right PS-module.

  13. Recombination dynamics in coalesced a-plane GaN ELO structures investigated by high spatially and ps-time-resolved cathodoluminescence microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Bastek, B.; Bertram, F.; Christen, J. [Institute of Experimental Physics, Otto-von-Guericke-University Magdeburg (Germany); Wernicke, T.; Weyers, M. [Ferdinand-Braun-Institut fuer Hoechstfrequenztechnik, Berlin (Germany); Kneissl, M. [Institute of Solid State Physics, Technical University, Berlin (Germany)

    2008-07-01

    The characteristic epitaxial lateral overgrowth (ELO) domains of fully coalesced a-plane GaN layers were directly imaged by highly spatially and spectrally resolved cathodoluminescence microscopy (CL) at 5 K. The patterned layers were grown by MOVPE on r-plane sapphire substrate and stripe masks oriented in the [01 anti 10] direction. In the area of coherent growth (I) the broad basal plane stacking fault (BSF) emission centered at 3.41 eV dominates the spectra. Also in the region (II) of coalescence the BSF luminescence dominates, however, the intensity increases by one order of magnitude compared to area (I). In complete contrast, in the stripes associated with the laterally grown domains (III) in [0001] direction, exclusively an intense and sharp (D{sup 0},X) emission at 3.475 eV is observed. ps-time-resolved CL of the free excitons (FX) recorded from this domains (III) decays bi-exponentially. The initial lifetime of 180 ps is primarily given by the capture of FX by impurities to form bound excitons (BE). With rising temperature this capture time constant decreases as T{sup -1/4} and reaches a minimum of 104 ps at T=60 K. Above 60 K, i.e. when FX starts to dominate the BEs, the lifetime increases rapidly to a value of 240 ps for 300 K.

  14. Gender-Specific Hippocampal Dysrhythmia and Aberrant Hippocampal and Cortical Excitability in the APPswePS1dE9 Model of Alzheimer’s Disease

    Directory of Open Access Journals (Sweden)

    Anna Papazoglou

    2016-01-01

    Full Text Available Alzheimer’s disease (AD is a multifactorial disorder leading to progressive memory loss and eventually death. In this study an APPswePS1dE9 AD mouse model has been analyzed using implantable video-EEG radiotelemetry to perform long-term EEG recordings from the primary motor cortex M1 and the hippocampal CA1 region in both genders. Besides motor activity, EEG recordings were analyzed for electroencephalographic seizure activity and frequency characteristics using a Fast Fourier Transformation (FFT based approach. Automatic seizure detection revealed severe electroencephalographic seizure activity in both M1 and CA1 deflection in APPswePS1dE9 mice with gender-specific characteristics. Frequency analysis of both surface and deep EEG recordings elicited complex age, gender, and activity dependent alterations in the theta and gamma range. Females displayed an antithetic decrease in theta (θ and increase in gamma (γ power at 18-19 weeks of age whereas related changes in males occurred earlier at 14 weeks of age. In females, theta (θ and gamma (γ power alterations predominated in the inactive state suggesting a reduction in atropine-sensitive type II theta in APPswePS1dE9 animals. Gender-specific central dysrhythmia and network alterations in APPswePS1dE9 point to a functional role in behavioral and cognitive deficits and might serve as early biomarkers for AD in the future.

  15. Sub One-Hundred-PS Pyroelectric Detector Research and Evaluation Program at LASL

    International Nuclear Information System (INIS)

    McLellan, E.J.; Stotlar, S.C.

    1978-01-01

    Preliminary devices have been designed and evaluated with 1 ns and 90 ps FWHM CO 2 laser pulses. Good agreement between calculated and measured values of falltime and voltage responsivity has been obtained. The female SMA to male BNC connector appears to be the most desirable easily available package for sub-one-hundred ps CO 2 laser pulses. A new detector with an expected risetime of 13 ps has been designed

  16. Delay-line cables for the fast bumpers in the PS.

    CERN Multimedia

    CERN PhotoLab

    1976-01-01

    For 'continuous transfer' to the SPS, the beam accelerated in the PS is shaved off over several turns, so as to form a continuous sequence of bunches several times the length of the PS circumference. Fast bumpers, powered in a 'staircase' way, displace the PS beam stepwise towards the ejection septum. Each step lasts 2.1 microsec and the cable drums in this picture contain some of the bumper delay-lines of altogether 10 km.

  17. Lost in Location

    DEFF Research Database (Denmark)

    Hansen, Lone Koefoed

    2009-01-01

    traversed. While becoming destination aware, the individual loses her location awareness. The article proposes that the reason people get lost when using sat-nav is due to a wrong location-performative paradigm. As an alternative, the article introduces and analyzes two performance-related examples...... that illustrate an alternative location-performative paradigm: Meredith Warner's Lost/Found knitting series and Etter and Schecht's Melodious Walkabout. In both examples, the artist's hand becomes the intermediary between alien and location. Thus, by exploring how wayfinding can be a poetically situated...... performance, the article examines how the growing locative media industry can learn from the location-aware performative strategies employed by artists who create situated and urban performances for the curious participant. The academic frames employed in the analysis draw on psychogeography, site...

  18. Internet Geo-Location

    Science.gov (United States)

    2017-12-01

    INTERNET GEO-LOCATION DUKE UNIVERSITY DECEMBER 2017 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED STINFO COPY AIR...REPORT TYPE FINAL TECHNICAL REPORT 3. DATES COVERED (From - To) MAY 2014 – MAY 2017 4. TITLE AND SUBTITLE INTERNET GEO-LOCATION 5a. CONTRACT...of SpeedTest servers that are used by end users to measure the speed of their Internet connection. The servers log the IP address and the location

  19. Prognostic significance of cytosolic pS2 content in ovarian tumors

    International Nuclear Information System (INIS)

    Raigoso, P.; Allende, T.; Zeidan, N.; Llana, B.; Bernardo, L.; Roiz, C.; Tejuca, S.; Vazquez, J.; Lamelas, M.L.

    2002-01-01

    Aim: pS2 is an estrogen regulated peptide which has been associated with a good prognosis an with a more favorable response to treatment in breast cancer patients. In ovarian tumors, the expression of pS2 was demonstrated at both mRNA and protein levels. In addition, it has been showed significant association of pS2 with mucinous differentiation or well differentiation grade of the tumors. However, it is little know about the prognostic significance of the pS2 content in ovarian carcinomas. The aims of the present work were to analyze the cytosolic pS2 content in benign and malignant ovarian tumors, its relationship with clinico-pathologic parameters, steroid receptor status, and prognostic significance. Material and Methods: We analysed the cytosolic concentrations of pS2 in 91 specimen ovarian tissues by an immunoradiometric assay (ELSA-pS2, CIS, France). The tissues were 8 normal ovaries, 43 benign tumors and 40 malignant ovarian tumors. The same ovarian tissues processed to pS2 were analyzed to Estrogen (ER) and Progesterone (PgR) Receptor status. These steroid receptors were quantified biochemically following commercial ELISA method (ABBOTT Diagnostics, Germany). The relationship between cytosolic content and clinico-pathologic factors was examined by the Mann-Whitney or Kruskall-Wallis test. Correlation between steroid receptors and pS2 content was calculated with the Spearman test. Survival curves were calculated using the Kaplan-Meier method and compared by the log-rank test. Differences were considered significant at 5% probability level. Results: pS2 could be detected in 30 cases (32.9%) with values ranged from 0.04 to 89 ng/mg prt. Only one normal ovary showed detectable levels of pS2 and there were not differences in cytosolic content between benign and malignant ovarian tumors. The pS2 levels were only associated to mucinous differentiation in both benign and malignant ovarian tumors (p=0.029 and p=0.015, respectively). Significantly higher

  20. Facile Synthesis of Mono-Dispersed Polystyrene (PS/Ag Composite Microspheres via Modified Chemical Reduction

    Directory of Open Access Journals (Sweden)

    Wen Zhu

    2013-12-01

    Full Text Available A modified method based on in situ chemical reduction was developed to prepare mono-dispersed polystyrene/silver (PS/Ag composite microspheres. In this approach; mono-dispersed PS microspheres were synthesized through dispersion polymerization using poly-vinylpyrrolidone (PVP as a dispersant at first. Then, poly-dopamine (PDA was fabricated to functionally modify the surfaces of PS microspheres. With the addition of [Ag(NH32]+ to the PS dispersion, [Ag(NH32]+ complex ions were absorbed and reduced to silver nanoparticles on the surfaces of PS-PDA microspheres to form PS/Ag composite microspheres. PVP acted both as a solvent of the metallic precursor and as a reducing agent. PDA also acted both as a chemical protocol to immobilize the silver nanoparticles at the PS surface and as a reducing agent. Therefore, no additional reducing agents were needed. The resulting composite microspheres were characterized by TEM, field emission scanning electron microscopy (FESEM, energy-dispersive X-ray spectroscopy (EDS, XRD, UV-Vis and surface-enhanced Raman spectroscopy (SERS. The results showed that Ag nanoparticles (NPs were homogeneously immobilized onto the PS microspheres’ surface in the presence of PDA and PVP. PS/Ag composite microspheres were well formed with a uniform and compact shell layer and were adjustable in terms of their optical property.

  1. Smart Location Database - Service

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Smart Location Database (SLD) summarizes over 80 demographic, built environment, transit service, and destination accessibility attributes for every census block...

  2. Smart Location Database - Download

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Smart Location Database (SLD) summarizes over 80 demographic, built environment, transit service, and destination accessibility attributes for every census block...

  3. Effect of Areal Density of Polymer Chains on Gold Nanoparticles on Nanoparticle Location in a Block Copolymer Template

    Science.gov (United States)

    Kim, B. J.; Bang, J.; Hawker, C. J.; Kramer, E. J.

    2006-03-01

    It is well established that one block of a copolymer can interact preferentially with an inorganic substrate to produce wetting and domain orientation. We take advantage of this preferential interaction to control the location of 2.5 nm diameter Au nanoparticles coated with short thiol-terminated polystyrene (Mn=3.4 kg/mol) chains (PS-SH) in a symmetric poly(styrene-b-2 vinyl-pyridine) (PS-b-P2VP) diblock copolymer (Mn=196 kg/mol) by changing the areal density σ of the PS-SH on the Au. If σ >= 1.6 chains/nm^2, the preferential interaction between the P2VP of the PS-b-P2VP and the Au surface is screened and the Au localizes in the center of the PS domains. If σ <= 1.4 chains/nm^2 , the Au particles are localized at the PS-P2VP interface. Au nanoparticles coated with thiol terminated P2VP (Mn=3 kg/mol) localize in the center of the P2VP domain of the PS-P2VP over the entire range of σ, demonstrating the localization of the PS coated Au nanoparticles at the interface at low values of σ is due to the unscreened Au-P2VP interaction.

  4. Using PS-InSAR data in landslide hazard management: the case of Veneto Region (NE Italy)

    Science.gov (United States)

    Floris, Mario; Viganò, Alessandro; Busnardo, Enrico; Arziliero, Luciano; Zanette, Doriano

    2013-04-01

    The Project Persistent Scatterers Interferometry, performed by the Italian Ministry of Environment and Territory of the Sea (METS) in the framework of the Extraordinary Plan of Environmental Remote Sensing, has made available a high quantity of data useful for local Authorities (Regions, Provinces, and Municipalities) in the management of the main geological hazards, such as landslides, subsidence, and sinkholes. The main output of the Project consists of ground displacements and velocities measured at target points over the entire Italian territory by using PS-InSAR processing technique applied to SAR data acquired by satellites ESA (European Space Agency) ERS-1 and ERS-2 (Earth Resources Satellite) and ENVISAT (Environmental Satellite) in the period 1992-2010. Description and results of the Project are available for public browsing at the geoportal of the METS (http://www.pcn.minambiente.it). On the basis of PS-InSAR data, several studies have been recently performed for the identification and characterization of landslides both at small and large scale. These studies led to a more precise delimitation of instable areas and to a better evaluation of the state of activity of mass movements. But, as now well known, interferometry techniques can't be applied to the whole territory due to geometric distortions in SAR data acquisition and to ground conditions. In this work we analyze the potentiality of PS-InSAR data from the Project Persistent Scatterers Interferometry in landslide hazard management of the Veneto Region, located in the north-eastern part of Italy. A synthetic description on the main features of landslides affecting the Region is reported, then the percentage of instabilities where PS-InSAR data can be used, is calculated. At the scale of the entire Region we suggest to follow the method proposed in the scientific literature to evaluate the state of activity of landslides on the basis of the measured velocities at the ground surface, while at local

  5. Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice

    Directory of Open Access Journals (Sweden)

    Lianne Hoeijmakers

    2018-03-01

    Full Text Available Life-time experiences are thought to influence the risk to develop the neurodegenerative disorder Alzheimer’s disease (AD. In particular, early-life stress (ES may modulate the onset and progression of AD. There is recent evidence by our group and others that AD-related neuropathological progression and the associated neuroimmune responses are modulated by ES in the classic APPswe/PS1dE9 mouse model for AD. We here extend our previous study on ES mediated modulation of neuropathology and neuroinflammation and address in the same cohort of mice whether ES accelerates and/or aggravates AD-induced cognitive decline and alterations in the process of adult hippocampal neurogenesis (AHN, a form of brain plasticity. Chronic ES was induced by limiting bedding and nesting material during the first postnatal week and is known to induce cognitive deficits by 4 months in wild type (WT mice. The onset of cognitive decline in APP/PS1 mice generally starts around 6 months of age. We here tested mice at ages 2–4 months to study acceleration and at ages 8–10 months for aggravation of the APP/PS1 phenotype. ES-exposed WT and APP/PS1 mice were able to perform the object recognition (ORT and location tasks (OLT at 2 months of age. Interestingly, at 3 months, ES induced impairments in the performance of the OLT in WT, but not in APP/PS1 mice. APP/PS1 mice exhibited alterations in hippocampal cell proliferation and differentiation, but ES exposure did not further change this. At 9 months, APP/PS1 mice exhibited impaired performance in the Morris Water Maze (MWM task, as well as reductions in markers of the AHN process, which were not further modulated by ES exposure. In addition, we observed a so far unreported hyperactivity in ES-exposed mice at 8 months of age, which hampered assessment of cognitive functions in the ORT and OLT. In conclusion, while ES has been reported to modulate AD neuropathology and neuroinflammation before, it failed to accelerate or

  6. Green facility location

    NARCIS (Netherlands)

    Velázquez Martínez, J.C.; Fransoo, J.C.; Bouchery, Y.; Corbett, C.J.; Fransoo, J.C.; Tan, T.

    2017-01-01

    Transportation is one of the main contributing factors of global carbon emissions, and thus, when dealing with facility location models in a distribution context, transportation emissions may be substantially higher than the emissions due to production or storage. Because facility location models

  7. Industrial location and competitiveness

    NARCIS (Netherlands)

    S. Brakman (Steven); J.H. Garretsen (Harry); J.G.M. van Marrewijk (Charles)

    2006-01-01

    textabstractThe interaction between the extent of location advantages and the intensity of firm competition relative to the size of the market jointly determines the location of industrial activity. Technology, factor endowments, geography, and scale economies are influential for determining

  8. ToPS: a framework to manipulate probabilistic models of sequence data.

    Directory of Open Access Journals (Sweden)

    André Yoshiaki Kashiwabara

    Full Text Available Discrete Markovian models can be used to characterize patterns in sequences of values and have many applications in biological sequence analysis, including gene prediction, CpG island detection, alignment, and protein profiling. We present ToPS, a computational framework that can be used to implement different applications in bioinformatics analysis by combining eight kinds of models: (i independent and identically distributed process; (ii variable-length Markov chain; (iii inhomogeneous Markov chain; (iv hidden Markov model; (v profile hidden Markov model; (vi pair hidden Markov model; (vii generalized hidden Markov model; and (viii similarity based sequence weighting. The framework includes functionality for training, simulation and decoding of the models. Additionally, it provides two methods to help parameter setting: Akaike and Bayesian information criteria (AIC and BIC. The models can be used stand-alone, combined in Bayesian classifiers, or included in more complex, multi-model, probabilistic architectures using GHMMs. In particular the framework provides a novel, flexible, implementation of decoding in GHMMs that detects when the architecture can be traversed efficiently.

  9. Phosphorene-directed self-assembly of asymmetric PS-b-PMMA block copolymer for perpendicularly-oriented sub-10 nm PS nanopore arrays

    Science.gov (United States)

    Zhang, Ziming; Zheng, Lu; Khurram, Muhammad; Yan, Qingfeng

    2017-10-01

    Few-layer black phosphorus, also known as phosphorene, is a new two-dimensional material which is of enormous interest for applications, mainly in electronics and optoelectronics. Herein, we for the first time employ phosphorene for directing the self-assembly of asymmetric polystyrene-block-polymethylmethacrylate (PS-b-PMMA) block copolymer (BCP) thin film to form the perpendicular orientation of sub-10 nm PS nanopore arrays in a hexagonal fashion normal to the interface. We experimentally demonstrate that none of the PS and PMMA blocks exhibit preferential affinity to the phosphorene-modified surface. Furthermore, the perpendicularly-oriented PS nanostructures almost stay unchanged with the variation of number of layers of few-layer phosphorene nanoflakes between 15-30 layers. Differing from the neutral polymer brushes which are widely used for chemical modification of the silicon substrate, phosphorene provides a novel physical way to control the interfacial interactions between the asymmetric PS-b-PMMA BCP thin film and the silicon substrate. Based on our results, it is possible to build a new scheme for producing sub-10 nm PS nanopore arrays oriented perpendicularly to the few-layer phosphorene nanoflakes. Furthermore, the nanostructural microdomains could serve as a promising nanolithography template for surface patterning of phosphorene nanoflakes.

  10. Phosphorene-directed self-assembly of asymmetric PS-b-PMMA block copolymer for perpendicularly-oriented sub-10 nm PS nanopore arrays.

    Science.gov (United States)

    Zhang, Ziming; Zheng, Lu; Khurram, Muhammad; Yan, Qingfeng

    2017-10-20

    Few-layer black phosphorus, also known as phosphorene, is a new two-dimensional material which is of enormous interest for applications, mainly in electronics and optoelectronics. Herein, we for the first time employ phosphorene for directing the self-assembly of asymmetric polystyrene-block-polymethylmethacrylate (PS-b-PMMA) block copolymer (BCP) thin film to form the perpendicular orientation of sub-10 nm PS nanopore arrays in a hexagonal fashion normal to the interface. We experimentally demonstrate that none of the PS and PMMA blocks exhibit preferential affinity to the phosphorene-modified surface. Furthermore, the perpendicularly-oriented PS nanostructures almost stay unchanged with the variation of number of layers of few-layer phosphorene nanoflakes between 15-30 layers. Differing from the neutral polymer brushes which are widely used for chemical modification of the silicon substrate, phosphorene provides a novel physical way to control the interfacial interactions between the asymmetric PS-b-PMMA BCP thin film and the silicon substrate. Based on our results, it is possible to build a new scheme for producing sub-10 nm PS nanopore arrays oriented perpendicularly to the few-layer phosphorene nanoflakes. Furthermore, the nanostructural microdomains could serve as a promising nanolithography template for surface patterning of phosphorene nanoflakes.

  11. VME Switch for CERN's PS Analog Video System

    CERN Document Server

    Acebes, I; Heinze, W; Lewis, J; Serrano, J

    2003-01-01

    Analog video signal switching is used in CERN's Proton Synchrotron (PS) complex to route the video signals coming from Beam Diagnostics systems to the Meyrin Control Room (MCR). Traditionally, this has been done with custom electromechanical relay-based cards controlled serially via CAMAC crates. In order to improve the robustness and maintainability of the system, while keeping it analog to preserve the low latency, a VME card based on Analog Devices' AD8116 analog matrix chip has been developed. Video signals go into the front panel and exit the switch through the P2 connector of the VME backplane. The module is a 16 input, 32 output matrix. Larger matrices can be built using more modules and bussing their outputs together, thanks to the high impedance feature of the AD8116. Another VME module takes the selected signals from the P2 connector and performs automatic gain to send them at nominal output level through its front panel. This paper discusses both designs and presents experimental test results.

  12. The (7,7) optics at CERN PS

    CERN Document Server

    Serluca, M; Efthymiopoulos, I; Sperati, F; Sterbini, G; Tecker, F; Zisopoulos, P

    2017-01-01

    The PS lattice is composed by one hundred combinedfunction magnets, which set the bare tune of the machineto (Qh,Qv) = (6.25, 6.28). Low energy quadrupoles areused at injection to move the tune in a limited working pointarea. In particular the vertical tune is moved below 6.25 toavoid the structural resonance 8Qv= 50 coupled with spacecharge, which leads to strong losses. In view of the highdemands in terms of beam brightness for LIU and HL-LHCprojects, the interest of exploring different integer tune work-ing area started during last years. During 2016, for the firsttime, it has been possible to explore the (7,7) tune workingarea at injection using the auxiliary circuits of the combinedfunction magnets. A finite-element magnetic model, underdevelopment, has been used to predict the required currentsin order to get the desired optical parameters. In this pa-per we present the results and issues encountered duringthe Machine Development (MD) studies about the injectionin the (7,7) area along with optics and be...

  13. Injection Bump Synchronization Study for the CERN PS

    CERN Document Server

    Serluca, Maurizio; Gilardoni, Simone; CERN. Geneva. ATS Department

    2016-01-01

    In the framework of the LHC Injector Upgrade (LIU) project the CERN PS injection kinetic energy will be upgraded from 1.4 to 2 GeV. The present injection bump is made by four bumpers in Straight Section (SS) 40, 42, 43, 44 and it will be converted in a five bumpers system to allow additional flexibility in the bump shape with a reduction of the proton losses during the bump closure. The injection section SS42 has being redesigned to accommodate a new eddy current septum which will host a new bumper magnet in the same vacuum vessel due to reduced longitudinal space availability. The synchronization and amplitude variation of the power converter of the in-vacuum bumper 42 with respect to the remaining outside vacuum bumpers 40, 41, 43, 44 can lead to orbit distortion and consequent losses during injection. In this note we present the experimental results from Machine Development (MD) studies along with simulations for the present system at 1.4 GeV to quantify the acceptable orbit distortion and the performance ...

  14. Vibrational bands of luminescent zinc(II)-octaethyl-porphyrin using a polarization-sensitive 'microcopic' multiplex CARS technique

    NARCIS (Netherlands)

    Otto, Cornelis; Voroshilov, A.; Voroshilov, Artemy; Kruglik, S.; Kruglik, S.G.; Greve, Jan

    2001-01-01

    Polarization-sensitive, multiplex coherent anti-Stokes Raman scattering (ps-MCARS) has been used to detect the vibrational bands of the highly luminescent zinc(II)-octaethylporphyrin (Zn-OEP). We show here that ps-MCARS can be used to measure the vibrational bands under resonant conditions.

  15. Fs-transient absorption and fluorescence upconversion after two- photon excitation of carotenoids in solution and in LHC II

    CERN Document Server

    Wall, P J; Fleming, G R

    2000-01-01

    With time resolved two-photon techniques we determined the lifetime and two-photon spectrum of the forbidden S/sub 1/ state of beta - carotene (9+or-0.2 ps), lutein (15+or-0.5 ps) and the energy transferring carotenoids in LHC II (250+or-50 fs). (7 refs).

  16. Positron Annihilation Ratio Spectroscopy (PsARS) Applied to Positronium Formation Studies

    Science.gov (United States)

    2010-03-01

    Positron Annihilation Ratio Spectroscopy (PsARS). These experimental techniques have been used for a variety of military and civilian applications ... POSITRON ANNIHILATION RATIO SPECTROSCOPY (PsARS) APPLIED TO POSITRONIUM FORMATION STUDIES THESIS...of Defense, or the United States Government. AFIT/GNE/ENP/10-M07 POSITRON ANNIHILATION RATIO SPECTROSCOPY

  17. Understanding Craftsman’s Creativity in a Framework of Person, Process, Product and Press (4Ps)

    DEFF Research Database (Denmark)

    Zhang, Hui; Zhou, Chunfang; Tanggaard, Lene

    2016-01-01

    , Process, Product, and Press (4Ps) This research question drives to develop a theoretical study bridging two areas of creativity and craftsman’s work. This will further indicate craftsman’s working practice is full of complexity that stimulates creative behavior and that also requires a systematic view...... to understand craftsman’s creativity as involving interaction between 4Ps....

  18. 76 FR 35683 - Medicare Program; Conditions of Participation (CoPs) for Community Mental Health Centers

    Science.gov (United States)

    2011-06-17

    ... Community Mental Health Centers; Proposed Rule #0;#0;Federal Register / Vol. 76 , No. 117 / Friday June 17... (CoPs) for Community Mental Health Centers AGENCY: Centers for Medicare & Medicaid Services (CMS), HHS... participation (CoPs) that community mental health centers (CMHCs) would have to meet in order to participate in...

  19. Rahuoperatsioonide Keskuses alustab sotsiaalse ja psühholoogilise toetuse sektsioon / Merle Tihaste, Marge Sillaste

    Index Scriptorium Estoniae

    Parmak, Merle, 1968-

    2008-01-01

    Missioonidel osalevatele või pikaajalises lähetuses viibivatele kaitseväelastele ja nende peredele suunatud sotsiaalse ja psühholoogilise toetuse tagamiseks loodud sektsioonist Rahuoperatsioonide Keskuse koosseisus. Sektsiooni töömudelist, ülesannetest ja koostöövõrgustikust. Skeem: Sotsiaalse ja psühholoogilise toetuse sektsiooni töömudel ja partnerid

  20. A paralogous decoy protects Phytophthora sojae apoplastic effector PsXEG1 from a host inhibitor.

    Science.gov (United States)

    Ma, Zhenchuan; Zhu, Lin; Song, Tianqiao; Wang, Yang; Zhang, Qi; Xia, Yeqiang; Qiu, Min; Lin, Yachun; Li, Haiyang; Kong, Liang; Fang, Yufeng; Ye, Wenwu; Wang, Yan; Dong, Suomeng; Zheng, Xiaobo; Tyler, Brett M; Wang, Yuanchao

    2017-02-17

    The extracellular space (apoplast) of plant tissue represents a critical battleground between plants and attacking microbes. Here we show that a pathogen-secreted apoplastic xyloglucan-specific endoglucanase, PsXEG1, is a focus of this struggle in the Phytophthora sojae -soybean interaction. We show that soybean produces an apoplastic glucanase inhibitor protein, GmGIP1, that binds to PsXEG1 to block its contribution to virulence. P. sojae , however, secretes a paralogous PsXEG1-like protein, PsXLP1, that has lost enzyme activity but binds to GmGIP1 more tightly than does PsXEG1, thus freeing PsXEG1 to support P. sojae infection. The gene pair encoding PsXEG1 and PsXLP1 is conserved in many Phytophthora species, and the P. parasitica orthologs PpXEG1 and PpXLP1 have similar functions. Thus, this apoplastic decoy strategy may be widely used in Phytophthora pathosystems. Copyright © 2017, American Association for the Advancement of Science.

  1. Semi-empirical formula for large pore-size estimation from o-Ps annihilation lifetime

    International Nuclear Information System (INIS)

    Nguyen Duc Thanh; Tran Quoc Dung; Luu Anh Tuyen; Khuong Thanh Tuan

    2007-01-01

    The o-Ps annihilation rate in large pore was investigated by the semi-classical approach. The semi-empirical formula that simply correlates between the pore size and the o-Ps lifetime was proposed. The calculated results agree well with experiment in the range from some angstroms to several ten nanometers size of pore. (author)

  2. Emission properties of porphyrin compounds in new polymeric PS:CBP host

    Science.gov (United States)

    Jafari, Mohammad Reza; Bahrami, Bahram

    2015-06-01

    In this study, a device with fundamental structure of ITO/PEDOT:PSS (60 nm)/PS:CBP (70 nm)/Al (150 nm) was fabricated. The electroluminescence spectrum of device designated a red shift rather than PS:CBP photoluminescence spectra. It can be suggested that the electroplex emission occurs at PS:CBP interface. By following this step, red light-emitting devices using porphyrin compounds as a red dopant in a new host material PS:CBP with a configuration of ITO/PEDOT:PSS (60 nm)/PS:CBP:porphyrin compounds(70 nm)/Al (150 nm) have been fabricated and investigated. The electroluminescent spectra of the porphyrin compounds were red-shifted as compared with the PS:CBP blend. OLED devices based on doping 3,4PtTPP and TPPNO2 in PS:CBP showed purer red emission compared with ZnTPP and CoTPP doped devices. We believe that the electroluminescence performance of OLED devices based on porphyrin compounds depends on overlaps between the absorption of the porphyrin compounds and the emission of PS:CBP.

  3. On the ortho-positronium quenching reactions promoted by Fe(II), Fe(III), Co(III), Ni(II), Zn(II) and Cd(II) cyanocomplexes

    Science.gov (United States)

    Fantola Lazzarini, Anna L.; Lazzarini, Ennio

    The o-Ps quenching reactions promoted in aqueous solutions by the following six cyanocomplexes: [Fe(CN) 6] 4-; [Co(CN) 6] 3-; [Zn(CN) 4] 2-; [Cd(CN) 6] 2-; [Fe(CN) 6] 3-; [Ni(CN) 4] 2- were investigated. The first four reactions probably consist in o-Ps addition across the CN bond, their rate constants at room temperature, Tr, being ⩽(0.04±0.02) × 10 9 M -1 s -1, i.e. almost at the limit of experimental errors. The rate constant of the fifth reaction, in o-Ps oxydation, at Tr is (20.3±0.4) × 10 9 M -1 s -1. The [Ni(CN) 4] 2-k value at Tr, is (0.27±0.01) × 10 9 M -1 s -1, i.e. 100 times less than the rate constants of o-Ps oxydation, but 10 times larger than those of the o-Ps addition across the CN bond. The [Ni(CN) 4] 2- reaction probably results in formation of the following positronido complex: [Ni(CN) 4Ps] 2-. However, it is worth noting that the existence of such a complex is only indirectly deduced. In fact it arises from comparison of the [Ni(CN) 4] 2- rate constant with those of the Fe(II), Zn(II), Cd(II), and Co(III) cyanocomplexes, which, like the Ni(II) cyanocomplex, do not promote o-Ps oxydation or spin exchange reactions.

  4. 21 CFR 886.4400 - Electronic metal locator.

    Science.gov (United States)

    2010-04-01

    ...) MEDICAL DEVICES OPHTHALMIC DEVICES Surgical Devices § 886.4400 Electronic metal locator. (a) Identification. An electronic metal locator is an AC-powered device with probes intended to locate metallic foreign bodies in the eye or eye socket. (b) Classification. Class II. ...

  5. Preliminary Evaluation of PS300: A New Self-Lubricating High Temperature Composite Coating for Use to 800 C

    Science.gov (United States)

    Dellacorte, C.; Edmonds, B. J.

    1995-01-01

    This paper introduces PS300, a plasma sprayed, self-lubricating composite coating for use in sliding contacts at temperatures to 800 C. PS300 is a metal bonded chrome oxide coating with silver and BaF2/CaF2 eutectic solid lubricant additives. PS300 is similar to PS200, a chromium carbide based coating, which is currently being investigated for a variety of tribological applications. In pin-on-disk testing up to 650 C, PS300 exhibited comparable friction and wear properties to PS200. The PS300 matrix, which is predominantly chromium oxide rather than chromium carbide, does not require diamond grinding and polishes readily with silicon carbide abrasives greatly reducing manufacturing costs compared to PS200. It is anticipated that PS300 has potential for sliding bearing and seal applications in both aerospace and general industry.

  6. Allegheny County Dam Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset shows the point locations of dams in Allegheny County. If viewing this description on the Western Pennsylvania Regional Data Center’s open data portal...

  7. Smart Location Mapping

    Science.gov (United States)

    The Smart Location Database, Access to Jobs and Workers via Transit, and National Walkability Index tools can help assess indicators related to the built environment, transit accessibility, and walkability.

  8. OAS :: Our Locations

    Science.gov (United States)

    the Human Resources of the OAS, including its organizational structure, each organizational unit's contract and travel control measure reports, the applicable procurement rules and regulations, and the Charter Organizational Charts Organizational List Authorities Our Locations Contact Us Telephone: +1 (202

  9. VT Hospital Site Locations

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) This data layer contains point locations of all major community, regional, comprehensive health, and healthcare provider hospitals in the state of...

  10. SGA Project Locations

    Data.gov (United States)

    Vermont Center for Geographic Information — The stream geomorphic assessment is a physical assessment competed by geomorphologists to determine the condition and sensitivity of a stream. The SGA locations...

  11. Waste Recovery Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Locations where City residents are encouraged to drop off and dispose or recycle of unwanted materials. Information provided is subject to change. Please call ahead...

  12. Global Volcano Locations Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NGDC maintains a database of over 1,500 volcano locations obtained from the Smithsonian Institution Global Volcanism Program, Volcanoes of the World publication. The...

  13. USAID Activity Locations

    Data.gov (United States)

    US Agency for International Development — The USAID Activities dataset is a snapshot of activities supported by USAID including their geographical locations within countries at the time of the snapshot. The...

  14. Uranium Location Database

    Data.gov (United States)

    U.S. Environmental Protection Agency — A GIS compiled locational database in Microsoft Access of ~15,000 mines with uranium occurrence or production, primarily in the western United States. The metadata...

  15. Location-based Scheduling

    DEFF Research Database (Denmark)

    Andersson, Niclas; Christensen, Knud

    on the market. However, CPM is primarily an activity based method that takes the activity as the unit of focus and there is criticism raised, specifically in the case of construction projects, on the method for deficient management of construction work and continuous flow of resources. To seek solutions...... to the identified limitations of the CPM method, an alternative planning and scheduling methodology that includes locations is tested. Location-based Scheduling (LBS) implies a shift in focus, from primarily the activities to the flow of work through the various locations of the project, i.e. the building. LBS uses...... the graphical presentation technique of Line-of-balance, which is adapted for planning and management of work-flows that facilitates resources to perform their work without interruptions caused by other resources working with other activities in the same location. As such, LBS and Lean Construction share...

  16. Mutations in AtPS1 (Arabidopsis thaliana parallel spindle 1 lead to the production of diploid pollen grains.

    Directory of Open Access Journals (Sweden)

    Isabelle d'Erfurth

    2008-11-01

    Full Text Available Polyploidy has had a considerable impact on the evolution of many eukaryotes, especially angiosperms. Indeed, most--if not all-angiosperms have experienced at least one round of polyploidy during the course of their evolution, and many important crop plants are current polyploids. The occurrence of 2n gametes (diplogametes in diploid populations is widely recognised as the major source of polyploid formation. However, limited information is available on the genetic control of diplogamete production. Here, we describe the isolation and characterisation of the first gene, AtPS1 (Arabidopsis thaliana Parallel Spindle 1, implicated in the formation of a high frequency of diplogametes in plants. Atps1 mutants produce diploid male spores, diploid pollen grains, and spontaneous triploid plants in the next generation. Female meiosis is not affected in the mutant. We demonstrated that abnormal spindle orientation at male meiosis II leads to diplogamete formation. Most of the parent's heterozygosity is therefore conserved in the Atps1 diploid gametes, which is a key issue for plant breeding. The AtPS1 protein is conserved throughout the plant kingdom and carries domains suggestive of a regulatory function. The isolation of a gene involved in diplogamete production opens the way for new strategies in plant breeding programmes and progress in evolutionary studies.

  17. AFRICOM: Does Location Matter?

    Science.gov (United States)

    2009-03-01

    Decision Model,” 242-244. 26 Susan Hesse Owen & Mark S. Daskin , “Strategic Facility Location: A Review,” European Journal of Operational Research...Susan Hesse & Mark S. Daskin . “Strategic Facility Location: A Review,” European Journal of Operational Research 111 (1998), 423-447. Paye-Layeleh...ES) N/ A 10. SPONSORING/MONITORING AGENCY REPORT NUMBER 11. SUPPLEMENTARY NOTES The views expressed in this thesis are those of the author and

  18. Tribology and Microstructure of PS212 with a Cr2O3 Seal Coat

    Science.gov (United States)

    Sliney, Harold E.; Benoy, Patricia A.; Korenyi-Both, Andras; Dellacorte, Christopher

    1994-01-01

    PS212 is a plasma sprayed metal bonding chrome carbide coating with solid lubricant additives which has lubricating properties at temperatures up to about 900 deg C. The coating is diamond ground to achieve an acceptable tribological surface. But, as with many plasma spray coatings, PS212 is not fully-dense. In this study, a chromium oxide base seal coating is used in an attempt to seal any porosity that is open to the surface of the PS212 coating, and to study the effect of the sealant on the tribological properties of PS212. The results indicate that the seal coating reduces friction and wear when it is applied and then diamond ground leaving a thin layer of seal coating which fills in the surface pits of the PS212 coating.

  19. Inhibition of Ps Formation in Benzene and Cyclohexane by CH3CI and CH3Br

    DEFF Research Database (Denmark)

    Wikander, G.; Mogensen, O. E.; Pedersen, Niels Jørgen

    1983-01-01

    Positron-annihilation lifetime spectra have been measured for mixtures of CH3Cl and CH3Br in cyclohexane and of CH3Cl in benzene. The ortho-positronium (Ps) yield decreased monotonically from 38% and 43% in cyclohexane and benzene respectively to 11% in pure CH3Cl and 6% in pure CH3Br. The strength......− anions to form Ps. while it forms a bound state with the halides. X−. CH3Cl was a roughly three times weaker Ps inhibitor in benzene than in cyclohexane, which shows that CH3Cl− does not dechlorinate in times comparable to or shorter than 400–500 ps in benzene. An improved model for the explanation of Ps...

  20. Chemical resistance of core-shell particles (PS/PMMA polymerized by seeded suspension

    Directory of Open Access Journals (Sweden)

    Luiz Fernando Belchior Ribeiro

    2017-09-01

    Full Text Available Abstract Core-shell particles were produced on seeded suspension polymerization by using polystyrene (PS as polymer core, or seed, and methyl methacrylate (MMA as the shell forming monomer. Two synthesis routes were evaluated by varying the PS seed conversion before MMA addition. The main purpose of this work was to investigate the influence of synthesis routes on the morphology and chemical resistance of the resulting particles. 1H NMR spectroscopy showed that the use of PS seeds with lower conversion led to the formation of higher amount of poly(styrene-co-MMA. The copolymer acted as a compatibilizer, decreasing the interfacial energy between both homopolymers. As a consequence, a larger amount of reduced PMMA cluster were formed, as was revealed by TEM measurements. Samples in this system showed enhanced resistance to cyclohexane attack compared with pure PS, with a PS extraction of only 37% after 54 hours test.

  1. Chemical resistance of core-shell particles (PS/PMMA) polymerized by seeded suspension

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro, Luiz Fernando Belchior; Machado, Ricardo Antonio Francisco, E-mail: ricardo.machado@ufsc.br [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil). Departamento de Engenharia de Materiais; Gonçalves, Odinei Hess [Universidade Técnológica Federal do Paraná(UTFPR), Campo Mourão, PR (Brazil); Marangoni, Cintia [Universidade Federal de Santa Catarina (UFSC), Blumenau, SC (Brazil); Motz, Günter [Lehrstuhl Keramische Werkstoffe, Universität Bayreuth (Germany)

    2017-07-01

    Core-shell particles were produced on seeded suspension polymerization by using polystyrene (PS) as polymer core, or seed, and methyl methacrylate (MMA) as the shell forming monomer. Two synthesis routes were evaluated by varying the PS seed conversion before MMA addition. The main purpose of this work was to investigate the influence of synthesis routes on the morphology and chemical resistance of the resulting particles. {sup 1}H NMR spectroscopy showed that the use of PS seeds with lower conversion led to the formation of higher amount of poly(styrene-co-MMA). The copolymer acted as a compatibilizer, decreasing the interfacial energy between both homopolymers. As a consequence, a larger amount of reduced PMMA cluster were formed, as was revealed by TEM measurements. Samples in this system showed enhanced resistance to cyclohexane attack compared with pure PS, with a PS extraction of only 37% after 54 hours test. (author)

  2. On English Locative Subjects

    Directory of Open Access Journals (Sweden)

    Gabriela Brůhová

    2017-07-01

    Full Text Available The paper analyses English sentences with thematic locative subjects. These subjects were detected as translation counterparts of Czech sentenceinitial locative adverbials realized by prepositional phrases with the prepositions do (into, na (on, v/ve (in, z/ze (from complemented by a noun. In the corresponding English structure, the initial scene-setting adverbial is reflected in the thematic subject, which results in the locative semantics of the subject. The sentences are analysed from syntactic, semantic and FSP aspects. From the syntactic point of view, we found five syntactic patterns of the English sentences with a locative subject (SV, SVA, SVO, SVpassA and SVCs that correspond to Czech sentences with initial locative adverbials. On the FSP level the paper studies the potential of the sentences to implement the Presentation or Quality Scale. Since it is the “semantic content of the verb that actuates the presentation semantics of the sentence” (Duškova, 2015a: 260, major attention is paid to the syntactic-semantic structure of the verb. The analysis of the semantics of the English sentences results in the identification of two semantic classes of verbs which co-occur with the English locative subject.

  3. Intron-exon organization of the active human protein S gene PS. alpha. and its pseudogene PS. beta. : Duplication and silencing during primate evolution

    Energy Technology Data Exchange (ETDEWEB)

    Ploos van Amstel, H.; Reitsma, P.H.; van der Logt, C.P.; Bertina, R.M. (University Hospital, Leiden (Netherlands))

    1990-08-28

    The human protein S locus on chromosome 3 consists of two protein S genes, PS{alpha} and PS{beta}. Here the authors report the cloning and characterization of both genes. Fifteen exons of the PS{alpha} gene were identified that together code for protein S mRNA as derived from the reported protein S cDNAs. Analysis by primer extension of liver protein S mRNA, however, reveals the presence of two mRNA forms that differ in the length of their 5{prime}-noncoding region. Both transcripts contain a 5{prime}-noncoding region longer than found in the protein S cDNAs. The two products may arise from alternative splicing of an additional intron in this region or from the usage of two start sites for transcription. The intron-exon organization of the PS{alpha} gene fully supports the hypothesis that the protein S gene is the product of an evolutional assembling process in which gene modules coding for structural/functional protein units also found in other coagulation proteins have been put upstream of the ancestral gene of a steroid hormone binding protein. The PS{beta} gene is identified as a pseudogene. It contains a large variety of detrimental aberrations, viz., the absence of exon I, a splice site mutation, three stop codons, and a frame shift mutation. Overall the two genes PS{alpha} and PS{beta} show between their exonic sequences 96.5% homology. Southern analysis of primate DNA showed that the duplication of the ancestral protein S gene has occurred after the branching of the orangutan from the African apes. A nonsense mutation that is present in the pseudogene of man also could be identified in one of the two protein S genes of both chimpanzee and gorilla. This implicates that silencing of one of the two protein S genes must have taken place before the divergence of the three African apes.

  4. PS2013 Satellite Workshop on Photosynthetic Light-Harvesting Systems

    Energy Technology Data Exchange (ETDEWEB)

    Niederman, Robert A. [Rutgers Univ., New Brunswick, NJ (United States); Blankenship, Robert E. [Washington Univ., St. Louis, MO (United States); Frank, Harry A. [Univ. of Connecticut, Storrs, CT (United States)

    2015-02-07

    These funds were used for partial support of the PS2013 Satellite Workshop on Photosynthetic Light-Harvesting Systems, that was held on 8-11 August, 2013, at Washington University, St. Louis, MO. This conference, held in conjunction with the 16th International Congress on Photosynthesis/St. Louis, continued a long tradition of light-harvesting satellite conferences that have been held prior to the previous six international photosynthesis congresses. In this Workshop, the basis was explored for the current interest in replacing fossil fuels with energy sources derived form direct solar radiation, coupled with light-driven electron transport in natural photosynthetic systems and how they offer a valuable blueprint for conversion of sunlight to useful energy forms. This was accomplished through sessions on the initial light-harvesting events in the biological conversion of solar energy to chemically stored energy forms, and how these natural photosynthetic processes serve as a guide to the development of robust bio-hybrid and artificial systems for solar energy conversion into both electricity or chemical fuels. Organized similar to a Gordon Research Conference, a lively, informal and collegial setting was established, highlighting the exchange of exciting new data and unpublished results from ongoing studies. A significant amount of time was set aside for open discussion and interactive poster sessions, with a special session devoted to oral presentations by talented students and postdoctoral fellows judged to have the best posters. This area of research has seen exceptionally rapid progress in recent years, with the availability of a number of antenna protein structures at atomic resolution, elucidation of the molecular surface architecture of native photosynthetic membranes by atomic force microscopy and the maturing of ultrafast spectroscopic and molecular biological techniques for the investigation and manipulation of photosynthetic systems. The conferees

  5. Optimization of silver nanoparticles production by laser ablation in water using a 150-ps laser

    International Nuclear Information System (INIS)

    Stašić, J.; Živković, Lj.; Trtica, M.

    2016-01-01

    Silver nanoparticles were synthesized by laser ablation in liquid (water) using a 150-ps Nd:YAG laser. Due to their extraordinary characteristics, especially when obtained by this method providing high purity and high stability of colloids, silver NPs are nowadays highly important in various applications. The objective of this study was to optimize the process parameters in order to achieve the highest possible yield while retaining small particle size. Yield/mass concentration of the obtained particles was measured depending on different parameters: time of irradiation, pulse energy, position regarding the focus, and number of irradiation locations. The conditions providing relatively high yield, small particle size, highest production rate, and highest efficiency are 7 mJ, 15-min irradiation time (9000 pulses), and target position ∼4 mm in front of the lens focus. The results are compared with the results obtained by the longer nanosecond as well as the ultrashort pulsed lasers. A possible physical explanation is given.

  6. Optimization of silver nanoparticles production by laser ablation in water using a 150-ps laser

    Energy Technology Data Exchange (ETDEWEB)

    Stašić, J.; Živković, Lj.; Trtica, M., E-mail: etrtica@vinca.rs [University of Belgrade, Institute of Nuclear Sciences “Vinča” (Serbia)

    2016-12-15

    Silver nanoparticles were synthesized by laser ablation in liquid (water) using a 150-ps Nd:YAG laser. Due to their extraordinary characteristics, especially when obtained by this method providing high purity and high stability of colloids, silver NPs are nowadays highly important in various applications. The objective of this study was to optimize the process parameters in order to achieve the highest possible yield while retaining small particle size. Yield/mass concentration of the obtained particles was measured depending on different parameters: time of irradiation, pulse energy, position regarding the focus, and number of irradiation locations. The conditions providing relatively high yield, small particle size, highest production rate, and highest efficiency are 7 mJ, 15-min irradiation time (9000 pulses), and target position ∼4 mm in front of the lens focus. The results are compared with the results obtained by the longer nanosecond as well as the ultrashort pulsed lasers. A possible physical explanation is given.

  7. iPS cells to model CDKL5-related disorders.

    Science.gov (United States)

    Amenduni, Mariangela; De Filippis, Roberta; Cheung, Aaron Y L; Disciglio, Vittoria; Epistolato, Maria Carmela; Ariani, Francesca; Mari, Francesca; Mencarelli, Maria Antonietta; Hayek, Youssef; Renieri, Alessandra; Ellis, James; Meloni, Ilaria

    2011-12-01

    Rett syndrome (RTT) is a progressive neurologic disorder representing one of the most common causes of mental retardation in females. To date mutations in three genes have been associated with this condition. Classic RTT is caused by mutations in the MECP2 gene, whereas variants can be due to mutations in either MECP2 or FOXG1 or CDKL5. Mutations in CDKL5 have been identified both in females with the early onset seizure variant of RTT and in males with X-linked epileptic encephalopathy. CDKL5 is a kinase protein highly expressed in neurons, but its exact function inside the cell is unknown. To address this issue we established a human cellular model for CDKL5-related disease using the recently developed technology of induced pluripotent stem cells (iPSCs). iPSCs can be expanded indefinitely and differentiated in vitro into many different cell types, including neurons. These features make them the ideal tool to study disease mechanisms directly on the primarily affected neuronal cells. We derived iPSCs from fibroblasts of one female with p.Q347X and one male with p.T288I mutation, affected by early onset seizure variant and X-linked epileptic encephalopathy, respectively. We demonstrated that female CDKL5-mutated iPSCs maintain X-chromosome inactivation and clones express either the mutant CDKL5 allele or the wild-type allele that serve as an ideal experimental control. Array CGH indicates normal isogenic molecular karyotypes without detection of de novo CNVs in the CDKL5-mutated iPSCs. Furthermore, the iPS cells can be differentiated into neurons and are thus suitable to model disease pathogenesis in vitro.

  8. Search for Bs Oscillations at CDF II

    International Nuclear Information System (INIS)

    Menzemer, Stephanie

    2006-01-01

    We report updated results in the search for Bs flavor oscillations performed at CDF II. We analyze a dataset of approximately 355 pb-1 from proton-antiproton collisions at a center-of-mass energy of 1.96 TeV collected in 2002-2004 with the CDF II detector at the Tevatron Collider. Samples of both fully reconstructed Bs → Ds(3)π, and partially reconstructed, Bs → DslX, decays have been studied. A combination of opposite side tagging algorithms has been used to determine the flavor of the Bs mesons at production time. Information about the oscillation frequency of the system, Δms, is obtained by performing an amplitude scan of the data, from which an exclusion limit Δms ≥ 8.6 ps -1 (at 95% C.L.), with a measured sensitivity of 13.0 ps-1 has been derived; Combination with previously available measurements increases the world exclusion limit from 14.5 ps-1 to 16.6 ps-1 (at 95% C.L.)

  9. An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells

    Science.gov (United States)

    Wei, Tingyi; Chen, Wen; Wang, Xiukun; Zhang, Man; Chen, Jiayu; Zhu, Songcheng; Chen, Long; Yang, Dandan; Wang, Guiying; Jia, Wenwen; Yu, Yangyang; Duan, Tao; Wu, Minjuan; Liu, Houqi; Gao, Shaorong; Kang, Jiuhong

    2015-01-01

    The maturation of induced pluripotent stem cells (iPS) is one of the limiting steps of somatic cell reprogramming, but the underlying mechanism is largely unknown. Here, we reported that knockdown of histone deacetylase 2 (HDAC2) specifically promoted the maturation of iPS cells. Further studies showed that HDAC2 knockdown significantly increased histone acetylation, facilitated TET1 binding and DNA demethylation at the promoters of iPS cell maturation-related genes during the transition of pre-iPS cells to a fully reprogrammed state. We also found that HDAC2 competed with TET1 in the binding of the RbAp46 protein at the promoters of maturation genes and knockdown of TET1 markedly prevented the activation of these genes. Collectively, our data not only demonstrated a novel intrinsic mechanism that the HDAC2-TET1 switch critically regulates iPS cell maturation, but also revealed an underlying mechanism of the interplay between histone acetylation and DNA demethylation in gene regulation. PMID:25934799

  10. Exact PsTd invariant and PsTd symmetric breaking solutions, symmetry reductions and Bäcklund transformations for an AB-KdV system

    Science.gov (United States)

    Jia, Man; Lou, Sen Yue

    2018-05-01

    In natural and social science, many events happened at different space-times may be closely correlated. Two events, A (Alice) and B (Bob) are defined as correlated if one event is determined by another, say, B = f ˆ A for suitable f ˆ operators. A nonlocal AB-KdV system with shifted-parity (Ps, parity with a shift), delayed time reversal (Td, time reversal with a delay) symmetry where B =Ps ˆ Td ˆ A is constructed directly from the normal KdV equation to describe two-area physical event. The exact solutions of the AB-KdV system, including PsTd invariant and PsTd symmetric breaking solutions are shown by different methods. The PsTd invariant solution show that the event happened at A will happen also at B. These solutions, such as single soliton solutions, infinitely many singular soliton solutions, soliton-cnoidal wave interaction solutions, and symmetry reduction solutions etc., show the AB-KdV system possesses rich structures. Also, a special Bäcklund transformation related to residual symmetry is presented via the localization of the residual symmetry to find interaction solutions between the solitons and other types of the AB-KdV system.

  11. General minisum circle location

    DEFF Research Database (Denmark)

    Körner, Mark; Brimberg, Jack; Juel, Henrik

    2009-01-01

    In our paper we approximate a set of given points by a general circle. More precisely, we consider the problem of locating and scaling the unit ball of some given norm k1 with respect to xed points on the plane such that the sum of weighted distances between the circle and the xed points is minim......In our paper we approximate a set of given points by a general circle. More precisely, we consider the problem of locating and scaling the unit ball of some given norm k1 with respect to xed points on the plane such that the sum of weighted distances between the circle and the xed points...

  12. Location-based games

    DEFF Research Database (Denmark)

    Ejsing-Duun, Stine

    In this dissertation, it is explored which prerequisites are necessary in location-based games (LBGs) to make meaningful the meeting between players and spatiality with an emphasis on physical locations. Throughout the dissertation, it has been shown that LBGs affect players’ perception of and be...... possible. The practical contribution is my creation of the LBG Visions of Sara. People continue to play this game in Odense more than two years after its launch, and DJEEO uses it as a showcase, enabling the company to sell similar LBGs....

  13. Density functional theory study of bulk and single-layer magnetic semiconductor CrPS4

    Science.gov (United States)

    Zhuang, Houlong L.; Zhou, Jia

    2016-11-01

    Searching for two-dimensional (2D) materials with multifunctionality is one of the main goals of current research in 2D materials. Magnetism and semiconducting are certainly two desirable functional properties for a single 2D material. In line with this goal, here we report a density functional theory (DFT) study of bulk and single-layer magnetic semiconductor CrPS4. We find that the ground-state magnetic structure of bulk CrPS4 exhibits the A-type antiferromagnetic ordering, which transforms to ferromagnetic (FM) ordering in single-layer CrPS4. The calculated formation energy and phonon spectrum confirm the stability of single-layer CrPS4. The band gaps of FM single-layer CrPS4 calculated with a hybrid density functional are within the visible-light range. We also study the effects of FM ordering on the optical absorption spectra and band alignments for water splitting, indicating that single-layer CrPS4 could be a potential photocatalyst. Our work opens up ample opportunities of energy-related applications of single-layer CrPS4.

  14. The PS complex as proton pre-injector for the LHC - design and implementation report

    International Nuclear Information System (INIS)

    Benedikt, M.; Blas, A.; Borburgh, J.

    2000-01-01

    The LHC will be supplied with protons from the pre-injector chain comprising Linac2, PS Booster and PS. These accelerators have undergone a major upgrading programme during the last five years so as to meet the stringent requirements of the LHC. This implies that many high-intensity bunches of small emittance and tight spacing (25 ns) be available at the PS extraction energy (26 GeV/c). The upgrading project involved an increase of Linac2 current, new RF systems in the PS Booster and the PS, raising the PS Booster energy from 1 to 1.4 GeV, two-batch filling of the PS, and the installation of high-resolution beam profile measurement devices. With the project entering its final phase and most of the newly installed hardware now being operational, the emphasis switches to producing the nominal LHC beam and tackling the associated beam physics problems. This report describes all the hardware changes related to the upgrading project. (orig.)

  15. Antiphosphatidylserine/prothrombin antibodies (aPS/PT) as potential markers of antiphospholipid syndrome.

    Science.gov (United States)

    Vlagea, Alexandru; Gil, Antonio; Cuesta, Maria V; Arribas, Florencia; Diez, Jesús; Lavilla, Paz; Pascual-Salcedo, Dora

    2013-06-01

    The antiphospholipid antibodies present in antiphospholipid syndrome (APS) are directed at a number of phospholipid-binding proteins: β2 glycoprotein I (β2GPI), prothrombin, and so on. Antibodies directed at β2GPI are accepted as a classification criterion for APS, while the presence of antiprothrombin antibodies is not. In the present article, we investigated the possible role of antiphosphatidylserine/prothrombin antibodies (aPS/PT) as marker of APS on a cohort of 295 individuals with APS (95 primary APS and 45 secondary APS) and APS-related diseases. We found aPS/PT to be highly associated with venous thrombosis (immunoglobulin G [IgG] aPS/PT odds ratio [OR], 7.44; 95% confidence interval [CI], 3.97-13.92 and IgM aPS/PT OR, 2.54; 95% CI, 1.35-4.77) and obstetric abnormalities (IgG aPS/PT OR, 2.37; 95% CI, 1.04-5.43), but not with arterial thrombosis. A very high degree of concordance between the concentration of aPS/PT and lupus anticoagulant activity was demonstrated. Therefore, we support the inclusion of aPS/PT determination as second-level assay to confirm APS classification.

  16. Characterization of cucurbita maxima phloem serpin-1 (CmPS-1). A developmentally regulated elastase inhibitor.

    Science.gov (United States)

    Yoo, B C; Aoki, K; Xiang, Y; Campbell, L R; Hull, R J; Xoconostle-Cázares, B; Monzer, J; Lee, J Y; Ullman, D E; Lucas, W J

    2000-11-10

    We report on the molecular, biochemical, and functional characterization of Cucurbita maxima phloem serpin-1 (CmPS-1), a novel 42-kDa serine proteinase inhibitor that is developmentally regulated and has anti-elastase properties. CmPS-1 was purified to near homogeneity from C. maxima (pumpkin) phloem exudate and, based on microsequence analysis, the cDNA encoding CmPS-1 was cloned. The association rate constant (k(a)) of phloem-purified and recombinant His(6)-tagged CmPS-1 for elastase was 3.5 +/- 1.6 x 10(5) and 2.7 +/- 0.4 x 10(5) m(-)(1) s(-)(1), respectively. The fraction of complex-forming CmPS-1, X(inh), was estimated at 79%. CmPS-1 displayed no detectable inhibitory properties against chymotrypsin, trypsin, or thrombin. The elastase cleavage sites within the reactive center loop of CmPS-1 were determined to be Val(347)-Gly(348) and Val(350)-Ser(351) with a 3:2 molar ratio. In vivo feeding assays conducted with the piercing-sucking aphid, Myzus persicae, established a close correlation between the developmentally regulated increase in CmPS-1 within the phloem sap and the reduced ability of these insects to survive and reproduce on C. maxima. However, in vitro feeding experiments, using purified phloem CmPS-1, failed to demonstrate a direct effect on aphid survival. Likely roles of this novel phloem serpin in defense against insects/pathogens are discussed.

  17. Real-life experience of using conventional disease-modifying anti-rheumatic drugs (DMARDs) in psoriatic arthritis (PsA). Retrospective analysis of the efficacy of methotrexate, sulfasalazine, and leflunomide in PsA in comparison to spondyloarthritides other than PsA and literature review of the use of conventional DMARDs in PsA

    Science.gov (United States)

    Roussou, Euthalia; Bouraoui, Aicha

    2017-01-01

    Objective With the aim of assessing the response to treatment with conventional disease-modifying anti-rheumatic drugs (DMARDs) used in patients with psoriatic arthritis (PsA), data on methotrexate, sulfasalazine (SSZ), and leflunomide were analyzed from baseline and subsequent follow-up (FU) questionnaires completed by patients with either PsA or other spondyloarthritides (SpAs). Material and Methods A single-center real-life retrospective analysis was performed by obtaining clinical data via questionnaires administered before and after treatment. The indices used were erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Function Index (BASFI), wellbeing (WB), and treatment effect (TxE). The indices measured at baseline were compared with those measured on one occasion in a FU visit at least 1 year later. Results A total of 73 patients, 51 with PsA (mean age 49.8±12.8 years; male-to-female ratio [M:F]=18:33) and 22 with other SpAs (mean age 50.6±16 years; M:F=2:20), were studied. BASDAI, BASFI, and WB displayed consistent improvements during FU assessments in both PsA patients and controls in comparison to baseline values. SSZ exhibited better efficacy as confirmed by TxE in both PsA patients and controls. ESR and CRP displayed no differences in either the PsA or the SpA group between the cases before and after treatment. Conclusion Real-life retrospective analysis of three DMARDs used in PsA (and SpAs other than PsA) demonstrated that all three DMARDs that were used brought about improvements in BASDAI, BASFI, TxE, and WB. However, the greatest improvements at FU were seen with SSZ use in both PsA and control cohorts. PMID:28293446

  18. Modelling of Ne-like copper X-ray laser driven by 1.2 ps short pulse and 280 ps background pulse configuration

    International Nuclear Information System (INIS)

    Demir, A.; Kenar, N.; Goktas, H.; Tallents, G.J.

    2004-01-01

    Detailed simulations of Ne-like Cu x-ray laser are undertaken using the EHYBRID code. The atomic physics data are obtained using the Cowan code. The optimization calculations are performed in terms of the intensity of background and the time separation between the background and the short pulse. The optimum value is obtained for the conditions of a Nd:glass laser with 1.2 ps pulse at 4.4 x 10 15 W cm -2 irradiance pumping a plasma pre-formed by a 280 ps duration pulse at 5.4 x 10 12 W cm -2 with peak-to-peak pulse separation set at 300 ps. X-ray resonance lines between 6 A and 15 A emitted from copper plasmas have been simulated. Free-free and free-bound emission from the Si-, Al-, Mg-, Na-, Ne- and F-like ions is calculated in the simulation. (author)

  19. The Czech Locative Chameleon

    Directory of Open Access Journals (Sweden)

    Tarald Taraldsen

    2007-12-01

    Full Text Available We show that under certain circumstances, the Czech locative prepositions (LOC show up as directional prepositions (DIR and vice versa, (under different circumstances the Czech DIR PPs show up as LOC. We argue that such a chameleon life of the PPs is structurally dependent.

  20. Immigrants' location preferences

    DEFF Research Database (Denmark)

    Damm, Anna Piil

    This paper exploits a spatial dispersal policy for refugee immigrants to estimate the importance of local and regional factors for refugees' location preferences. The main results of a mixed proportional hazard competing risks model are that placed refugees react to high regional unemployment...

  1. Tracking, say, SKYPE Locations

    Indian Academy of Sciences (India)

    First page Back Continue Last page Graphics. Tracking, say, SKYPE Locations. Real Time Communication: Peer-to-Peer (P2P). Datagram flows between the two conversing partners; Exposes the IP addresses of all the participants to one another. If A knows B's VoIP ID, she can establish a call with Bob & obtain his current ...

  2. RFID Location Algorithm

    Directory of Open Access Journals (Sweden)

    Wang Zi Min

    2016-01-01

    Full Text Available With the development of social services, people’s living standards improve further requirements, there is an urgent need for a way to adapt to the complex situation of the new positioning technology. In recent years, RFID technology have a wide range of applications in all aspects of life and production, such as logistics tracking, car alarm, security and other items. The use of RFID technology to locate, it is a new direction in the eyes of the various research institutions and scholars. RFID positioning technology system stability, the error is small and low-cost advantages of its location algorithm is the focus of this study.This article analyzes the layers of RFID technology targeting methods and algorithms. First, RFID common several basic methods are introduced; Secondly, higher accuracy to political network location method; Finally, LANDMARC algorithm will be described. Through this it can be seen that advanced and efficient algorithms play an important role in increasing RFID positioning accuracy aspects.Finally, the algorithm of RFID location technology are summarized, pointing out the deficiencies in the algorithm, and put forward a follow-up study of the requirements, the vision of a better future RFID positioning technology.

  3. Spatiotemporal AED Location Optimization

    NARCIS (Netherlands)

    Chan, Timothy C.Y.; Sun, Christopher L.F.; Demirtas, Derya; Morrison, Laurie J.; Brooks, Steven C.

    2015-01-01

    Background: Mathematical optimization can be used to plan future AED placement to maximize out-of-hospital cardiac arrest (OHCA) coverage. Many public access AEDs are placed in locations without 24/7 access. AED coverage can be overestimated unless temporal availability is considered. Objective: To

  4. Location of New Firms

    DEFF Research Database (Denmark)

    Backman, Mikaela; Karlsson, Charlie

    2017-01-01

    characteristics, such as the commuting experience. Our results show that commuting influences the firm location choice. The probability of establishing a firm in the work municipality increases if the entrepreneur is a commuter, holding constant the type of region and unobservable and observable individual...

  5. POPS: the 60MW power converter for the PS accelerator: Control strategy and performances

    CERN Document Server

    Boattini, Fulvio; Skawinski, Gregory

    2015-01-01

    The main power supply of Proton-Synchrotron (PS) accelerator is one of the biggest at CERN. The old rotating machine system has been replaced with a new NPC based DC/DC power supply named POPS (Power system for PS main magnets) with capacitor banks as energy storage mean. POPS is in operation since February 2011. The operation of the PS accelerator requires a specific design of the control system with very high performance requirements in term of accuracy and precision. This paper describes the main lines of the control strategies analyzing the problems encountered and the solutions adopted. The performances of the converter are presented throughout the paper.

  6. LEADIR-PS: the path to a safe and economic SMR

    Energy Technology Data Exchange (ETDEWEB)

    Hart, R.S. [Nothern Nuclear Industries Inc., Cambridge, Ontario (Canada)

    2014-07-01

    Northern Nuclear Industries Incorporated (N{sup 2} I{sup 2}) is developing a family of Small Modular Reactors (SMRs) called LEADIR-PS, an acronym for LEAD-cooled Integral Reactor-Passively Safe. LEADIR-PS plants under development, focused on process heat applications and the energy demands of Canada, are the LEADIR-PS100 with an output of 100 MWth and LEADIR-PS300 with an output of 300 MWth. A plant consisting of six LEADIR-PS300 reactor modules serving a common turbine-generator, called the LEADIR-PS Six-Pack, is focused on serving areas with higher energy demands. LEADIR-PS integrates the inherent safety features of the Modular High Temperature Gas Reactor and molten lead coolant in an integral pool type reactor configuration. Molten lead coolant, which boils at 1750 {sup o}C,avoids the cost of a reactor pressure vessel and high pressure/high temperature reactor coolant systems, and the safety concerns regarding pressure vessel and large capacity reactor coolant system piping rupture and precludes evaporation of the coolant. Molten lead does not chemically react with air, water, or graphite. The Gen IV+ LEADIR-PS plants are inherently/passively safe. There are no active systems required for safe shutdown and decay heat removal. Safety is assured without active or stored energy power supply, without a requirement to reposition valves or other devices and operator intervention or action. The unprecedented safety achieved by LEADIR-PS reactors avoids requirements for a large exclusion radius and demanding evacuation plan requirements. LEADIR-PS, with steam conditions of 370 {sup o}C and 12 MPa (more than twice that of water cooled reactors), can serve over 85% of the world's non-transportation process heat demands and is ideally suited to serving Combined Heat and Electricity demands and industrial parks. Energy utilization of over 95% is feasible in process heat and Combined Heat and Electricity applications. The simple robust design of LEADIR-PS plants in

  7. Aquatic Nuisance Species Locator

    Science.gov (United States)

    Data in this map has been collected by the United States Geological Survey's Nonindigenous Aquatic Species program located in Gainesville, Florida (http://nas.er.usgs.gov/default.aspx). This dataset may have some inaccuracies and is only current to June 15, 2012. The species identified in this dataset are not inclusive of all aquatic nuisance species, but rather a subset identified to be at risk for transport by recreational activities such as boating and angling. Additionally, the locations where organisims have been identified are also not inclusive and should be treated as a guide. Organisms are limited to the following: American bullfrog, Asian clam, Asian shore crab, Asian tunicate, Australian spotted jellyfish, Chinese mitten crab, New Zealand mudsnail, Colonial sea squirt, Alewife, Bighead carp, Black carp, Flathead catfish, Grass carp, Green crab, Lionfish, Northern snakehead, Quagga mussel, Round Goby, Ruffe, Rusty crayfish, Sea lamprey, Silver carp, Spiny water flea, Veined rapa whelk, Zebra mussel

  8. Locating underground uranium deposits

    International Nuclear Information System (INIS)

    Felice, P.E.

    1979-01-01

    Underground uranium deposits are located by placing wires of dosimeters each about 5 to 18 mg/cm 2 thick underground in a grid pattern. Each dosimeter contains a phosphor which is capable of storing the energy of alpha particles. In each pair one dosimeter is shielded from alpha particles with more than 18 mg/cm 2 thick opaque material but not gamma and beta rays and the other dosimeter is shielded with less than 1 mg/cm 2 thick opaque material to exclude dust. After a period underground the dosimeters are heated which releases the stored energy as light. The amount of light produced from the heavily shielded dosimeter is subtracted from the amount of light produced from the thinly shielded dosimeter to give an indication of the location and quantity of uranium underground

  9. Web cache location

    Directory of Open Access Journals (Sweden)

    Boffey Brian

    2004-01-01

    Full Text Available Stress placed on network infrastructure by the popularity of the World Wide Web may be partially relieved by keeping multiple copies of Web documents at geographically dispersed locations. In particular, use of proxy caches and replication provide a means of storing information 'nearer to end users'. This paper concentrates on the locational aspects of Web caching giving both an overview, from an operational research point of view, of existing research and putting forward avenues for possible further research. This area of research is in its infancy and the emphasis will be on themes and trends rather than on algorithm construction. Finally, Web caching problems are briefly related to referral systems more generally.

  10. 75 FR 16748 - Final Voluntary Product Standard; DOC PS 20-10 “American Softwood Lumber Standard”

    Science.gov (United States)

    2010-04-02

    ...-0146-02] Final Voluntary Product Standard; DOC PS 20-10 ``American Softwood Lumber Standard'' AGENCY... of Standards and Technology (NIST) announces voluntary product standard DOC PS 20-10 ``American Softwood Lumber Standard'' which will supersede DOC PS 20-05. The Standard establishes standard sizes and...

  11. File list: Pol.PSC.05.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.PSC.05.AllAg.iPS_derived_neural_cells hg19 RNA polymerase Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.05.AllAg.iPS_derived_neural_cells.bed ...

  12. File list: Unc.PSC.50.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.50.AllAg.iPS_derived_neural_cells hg19 Unclassified Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Unc.PSC.50.AllAg.iPS_derived_neural_cells.bed ...

  13. File list: NoD.PSC.05.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.PSC.05.AllAg.iPS_derived_neural_cells hg19 No description Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.PSC.05.AllAg.iPS_derived_neural_cells.bed ...

  14. File list: InP.PSC.20.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.20.AllAg.iPS_derived_neural_cells hg19 Input control Pluripotent stem cell iPS derived neural... cells SRX702550 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.20.AllAg.iPS_derived_neural_cells.bed ...

  15. File list: ALL.PSC.20.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.PSC.20.AllAg.iPS_derived_neural_cells hg19 All antigens Pluripotent stem cell iPS derived neural...hive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.20.AllAg.iPS_derived_neural_cells.bed ...

  16. File list: Oth.PSC.05.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.AllAg.iPS_derived_neural_cells hg19 TFs and others Pluripotent stem cell iPS derived neural...X968908 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.05.AllAg.iPS_derived_neural_cells.bed ...

  17. File list: His.PSC.20.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.20.AllAg.iPS_derived_neural_cells hg19 Histone Pluripotent stem cell iPS derived neural...archive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.20.AllAg.iPS_derived_neural_cells.bed ...

  18. File list: DNS.PSC.10.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.PSC.10.AllAg.iPS_derived_neural_cells hg19 DNase-seq Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.10.AllAg.iPS_derived_neural_cells.bed ...

  19. File list: His.PSC.50.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.PSC.50.AllAg.iPS_derived_neural_cells hg19 Histone Pluripotent stem cell iPS derived neural...archive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.50.AllAg.iPS_derived_neural_cells.bed ...

  20. Location based services

    OpenAIRE

    Doan, Cong Nam

    2015-01-01

    Mobile devices (tablets, smart phones, laptops) are proving themselves to be the main means of accessing information of the future. The embodiment of Recommender Systems (RSs) into mobile environments, as a matter of fact, has come about to serve as a way to solve the nuisances of data overwhelming. RSs' main advantage is their ability to allow users to find useful information according to the users' preferences and location. Even though they are not free of shortcoming such as the limitation...

  1. Location Intelligence Solutions

    International Nuclear Information System (INIS)

    Schmidt, D.

    2015-01-01

    Location Intelligence (LI) means using the spatial dimension of information as a key to support business processes. This spatial dimension has to be defined by geographic coordinates. Storing these spatial objects in a database allows for attaching a 'meaning' to them, like 'current position', 'border', 'building' or 'room'. Now the coordinates represent real-world objects, which can be relevant for the measurement, documentation, control or optimization of (parameters of) business processes aiming at different business objectives. But LI can only be applied, if the locations can be determined with an accuracy (in space and time) appropriate for the business process in consideration. Therefore the first step in any development of a LI solution is the analysis of the business process itself regarding its requirements for spatial and time resolution and accuracy. The next step is the detailed analysis of the surrounding conditions of the process: Does the process happen indoor and/or outdoor? Are there moving objects? If yes, how fast are they? How does the relevant environment look like? Is technical infrastructure available? Is the process restricted by regulations? As a result, a proper Location Detection Technology (LDT) has to be chosen in order to get reliable and accurate positions of the relevant objects. At the highly challenging conditions of the business processes IAEA inspectors are working with, the chosen LDTs have to deliver reliable positioning on ''room-level'' accuracy, even if there is no location enabling infrastructure in place, the objects (people) mostly are indoors and have to work under strong regulations. The presentation will give insights into innovative LI solutions based on technologies of different LDT providers. Pros and cons of combinations of different LDT (like multi- GNSS, IMU, camera, and human interaction based positioning) will be discussed from the

  2. Ammonia Leak Locator Study

    Science.gov (United States)

    Dodge, Franklin T.; Wuest, Martin P.; Deffenbaugh, Danny M.

    1995-01-01

    The thermal control system of International Space Station Alpha will use liquid ammonia as the heat exchange fluid. It is expected that small leaks (of the order perhaps of one pound of ammonia per day) may develop in the lines transporting the ammonia to the various facilities as well as in the heat exchange equipment. Such leaks must be detected and located before the supply of ammonia becomes critically low. For that reason, NASA-JSC has a program underway to evaluate instruments that can detect and locate ultra-small concentrations of ammonia in a high vacuum environment. To be useful, the instrument must be portable and small enough that an astronaut can easily handle it during extravehicular activity. An additional complication in the design of the instrument is that the environment immediately surrounding ISSA will contain small concentrations of many other gases from venting of onboard experiments as well as from other kinds of leaks. These other vapors include water, cabin air, CO2, CO, argon, N2, and ethylene glycol. Altogether, this local environment might have a pressure of the order of 10(exp -7) to 10(exp -6) torr. Southwest Research Institute (SwRI) was contracted by NASA-JSC to provide support to NASA-JSC and its prime contractors in evaluating ammonia-location instruments and to make a preliminary trade study of the advantages and limitations of potential instruments. The present effort builds upon an earlier SwRI study to evaluate ammonia leak detection instruments [Jolly and Deffenbaugh]. The objectives of the present effort include: (1) Estimate the characteristics of representative ammonia leaks; (2) Evaluate the baseline instrument in the light of the estimated ammonia leak characteristics; (3) Propose alternative instrument concepts; and (4) Conduct a trade study of the proposed alternative concepts and recommend promising instruments. The baseline leak-location instrument selected by NASA-JSC was an ion gauge.

  3. Copper (II)

    African Journals Online (AJOL)

    CLEMENT O BEWAJI

    Valine (2 - amino - 3 – methylbutanoic acid), is a chemical compound containing .... Stability constant (Kf). Gibb's free energy. ) (. 1. −. ∆. Mol. JG. [CuL2(H2O)2] ... synthesis and characterization of Co(ii), Ni(ii), Cu (II), and Zn(ii) complexes with ...

  4. Psühhofüsioloogilised mängud / Kaivo Thomson

    Index Scriptorium Estoniae

    Thomson, Kaivo, 1956-

    2002-01-01

    Rmt.: Thomson, Kaivo. Psühhofüsioloogilised mängud : teooria & värvitoonide, helikõrguste ja liikumiskiiruste eristamisvõime testimine ning arendamine meetodiga "WinPsycho 2000" (CD-1). Tartu : Atlex, 2001.

  5. The surface properties of PS/PMMA blends nanostructured polymeric layers

    International Nuclear Information System (INIS)

    Prosycevas, I.; Tamulevicius, S.; Guobiene, A.

    2004-01-01

    Solvent cast thin films of blends polystyrene (PS) and poly (methylmethacrylate) (PMMA) with nominal compositions ranging from 25/75 wt.%/v% (w/v) up to 75/25 w/v PS/PMMA with toluene as the mutual solvent on crystalline Si (100) and silica substrates has been studied. Films of PS and PMMA blends have been examined by atomic force microscopy (AFM) and ellipsometry. The blend films with less than 50% PMMA bulk concentration generally exhibit pitted surfaces; the pit size varies with film thickness and bulk composition. When the PMMA bulk concentration is greater than 50%, the film surface can be described as island-like phase-separated structure. The surface segregation and morphology are explained in terms of solubility of the two polymers in the solvent and rewetting of PMMA relative to PS

  6. A high intensity beam handling system at the KEK-PS new experimental hall

    International Nuclear Information System (INIS)

    Tanaka, K.H.; Minakawa, M.; Yamanoi, Y.

    1991-01-01

    We would like to summarize newly developed technology for handling high-intensity beams. This was practically employed in the beam-handling system of primary protons at the KEK-PS new experimental hall. (author)

  7. An investigation into radiosensitizer mechanisms using o-Ps lifetime measurements

    International Nuclear Information System (INIS)

    Beling, C.D.; Smith, F.A.

    1982-01-01

    Lifetime measurements have been made in a number of radiosensitizer solutions as a function of both concentration and temperature. The o-Ps yields, which were corrected for chemical quenching, showed that these compounds are strong Ps inhibitors. The temperature dependence of the yields in Misonidazole/water and Misonidazole/ethanol solutions may be associated either with the different electron solvation times in the two solvents, or with changes in electron mobility. (Auth.)

  8. Perceptions of Community Health Workers (CHWs/PS in the U.S.-Mexico Border HEART CVD Study

    Directory of Open Access Journals (Sweden)

    Hector G. Balcazar

    2014-02-01

    Full Text Available Although prior research has shown that Community Health Workers/Promotores de Salud (CHW/PS can facilitate access to care, little is known about how CHW/PS are perceived in their community. The current study reports the findings of a randomized telephone survey conducted in a high-risk urban community environment along the U.S.-Mexico border. In preparation for a community-based CHW/PS intervention called the HEART ecological study, the survey aimed to assess perceptions of CHW/PS, availability and utilization of community resources (recreational and nutrition related and health behaviors and intentions. A total of 7,155 calls were placed to complete 444 surveys in three zip codes in El Paso, Texas. Results showed that participants felt that healthful community resources were available, but utilization was low and variable: 35% reported going to a park, 20% reported having taken a health class, few reported using a gym (12%, recreation center (8%, or YMCA/YWCA (0.9%. Awareness and utilization of CHW/PS services were low: 20% of respondents had heard of CHW/PS, with 8% reporting previous exposure to CHW/PS services. Upon review of a definition of CHW/PS, respondents expressed positive views of CHW/PS and their value in the healthcare system. Respondents who had previous contact with a CHW/PS reported a significantly more positive perception of the usefulness of CHW/PS (p = 0.006, were more likely to see CHW/PS as an important link between providers and patients (p = 0.008, and were more likely to ask a CHW/PS for help (p = 0.009. Participants who utilized CHW/PS services also had significantly healthier intentions to reduce fast food intake. Future research is needed to evaluate if CHW/PS can facilitate utilization of available community resources such as recreational facilities among Hispanic border residents at risk for CVD.

  9. Lightweight and Statistical Techniques for Petascale Debugging: Correctness on Petascale Systems (CoPS) Preliminry Report

    Energy Technology Data Exchange (ETDEWEB)

    de Supinski, B R; Miller, B P; Liblit, B

    2011-09-13

    Petascale platforms with O(10{sup 5}) and O(10{sup 6}) processing cores are driving advancements in a wide range of scientific disciplines. These large systems create unprecedented application development challenges. Scalable correctness tools are critical to shorten the time-to-solution on these systems. Currently, many DOE application developers use primitive manual debugging based on printf or traditional debuggers such as TotalView or DDT. This paradigm breaks down beyond a few thousand cores, yet bugs often arise above that scale. Programmers must reproduce problems in smaller runs to analyze them with traditional tools, or else perform repeated runs at scale using only primitive techniques. Even when traditional tools run at scale, the approach wastes substantial effort and computation cycles. Continued scientific progress demands new paradigms for debugging large-scale applications. The Correctness on Petascale Systems (CoPS) project is developing a revolutionary debugging scheme that will reduce the debugging problem to a scale that human developers can comprehend. The scheme can provide precise diagnoses of the root causes of failure, including suggestions of the location and the type of errors down to the level of code regions or even a single execution point. Our fundamentally new strategy combines and expands three relatively new complementary debugging approaches. The Stack Trace Analysis Tool (STAT), a 2011 R&D 100 Award Winner, identifies behavior equivalence classes in MPI jobs and highlights behavior when elements of the class demonstrate divergent behavior, often the first indicator of an error. The Cooperative Bug Isolation (CBI) project has developed statistical techniques for isolating programming errors in widely deployed code that we will adapt to large-scale parallel applications. Finally, we are developing a new approach to parallelizing expensive correctness analyses, such as analysis of memory usage in the Memgrind tool. In the first two

  10. Seismic Background Noise Analysis of BRTR (PS-43) Array

    Science.gov (United States)

    Ezgi Bakir, Mahmure; Meral Ozel, Nurcan; Umut Semin, Korhan

    2015-04-01

    The seismic background noise variation of BRTR array, composed of two sub arrays located in Ankara and in Ankara-Keskin, has been investigated by calculating Power Spectral Density and Probability Density Functions for seasonal and diurnal noise variations between 2005 and 2011. PSDs were computed within the frequency range of 100 s - 10 Hz. The results show us a little change in noise conditions in terms of time and location. Especially, noise level changes were observed at 3-5 Hz in diurnal variations at Keskin array and there is a 5-7 dB difference in day and night time in cultural noise band (1-10 Hz). On the other hand, noise levels of medium period array is high in 1-2 Hz frequency rather than short period array. High noise levels were observed in daily working times when we compare it to night-time in cultural noise band. The seasonal background noise variation at both sites also shows very similar properties to each other. Since these stations are borehole instruments and away from the coasts, we saw a small change in noise levels caused by microseism. Comparison between Keskin short period array and Ankara medium period array show us Keskin array is quiter than Ankara array.

  11. Mapping the mantle transition zone beneath the central Mid-Atlantic Ridge using Ps receiver functions.

    Science.gov (United States)

    Agius, M. R.; Rychert, C.; Harmon, N.; Kendall, J. M.

    2017-12-01

    Determining the mechanisms taking place beneath ridges is important in order to understand how tectonic plates form and interact. Of particular interest is establishing the depth at which these processes originate. Anomalies such as higher temperature within the mantle transition zone may be inferred seismically if present. However, most ridges are found in remote locations beneath the oceans restricting seismologists to use far away land-based seismometers, which in turn limits the imaging resolution. In 2016, 39 broadband ocean-bottom seismometers were deployed across the Mid-Atlantic Ridge, along the Romanche and Chain fracture zones as part of the PI-LAB research project (Passive Imaging of the Lithosphere and Asthenosphere Boundary). The one-year long seismic data is now retrieved and analysed to image the mantle transition zone beneath the ridge. We determine P-to-s (Ps) receiver functions to illuminate the 410- and 660-km depth mantle discontinuities using the extended multitaper deconvolution. The data from ocean-bottom seismometers have tilt and compliance noise corrections and is filtered between 0.05-0.2 Hz to enhance the signal. 51 teleseismic earthquakes generated hundreds of good quality waveforms, which are then migrated to depth in 3-D. The topography at the d410 deepens towards the west of the Romanche and Chain fracture zone by 15 km, whereas the topography of d660 shallows beneath the ridge between the two zones. Transition zone thickness thins from 5 to 20 km. Thermal anomalies determined from temperature relationships with transition zone thickness and depth variations of the d410 and d660 suggests hotter temperatures of about 200 K. Overall, the result suggests mid-ocean ridges may have associated thermal signatures as deep as the transition zone.

  12. Location Privacy with Randomness Consistency

    Directory of Open Access Journals (Sweden)

    Wu Hao

    2016-10-01

    Full Text Available Location-Based Social Network (LBSN applications that support geo-location-based posting and queries to provide location-relevant information to mobile users are increasingly popular, but pose a location-privacy risk to posts. We investigated existing LBSNs and location privacy mechanisms, and found a powerful potential attack that can accurately locate users with relatively few queries, even when location data is well secured and location noise is applied. Our technique defeats previously proposed solutions including fake-location detection and query rate limits.

  13. Indoor Location Technologies

    CERN Document Server

    Goswami, Subrata

    2013-01-01

    Focusing on the special challenges posed by accurately pinpointing a location indoors, this volume reflects the distance we have come in the handful of decades since the germination of GPS technology. Not only can we locate a signal to within a meter’s accuracy, but we now have this technology in the most basic mobile phone. Tracing recent practical developments in positioning technology and in the market it supplies, the author examines the contributions of the varied research—in silicon, signal and image processing, radio communications and software—to a fast-evolving field. The book looks forward to a time when, in addition to directing your road journey, positioning systems can peer indoors and guide you to an available photocopier in your office building. Featuring standalone chapters each dealing with a specific aspect of the subject, including treatments of systems such as Zebra, Awarepoint, Aeroscout, IEEE 802.11, etc. This study has all the detail needed to get up to speed on a key modern techn...

  14. Paper sludge (PS) to bioethanol: Evaluation of virgin and recycle mill sludge for low enzyme, high-solids fermentation.

    Science.gov (United States)

    Boshoff, Sonja; Gottumukkala, Lalitha Devi; van Rensburg, Eugéne; Görgens, Johann

    2016-03-01

    Paper sludge (PS) from the paper and pulp industry consists primarily of cellulose and ash and has significant potential for ethanol production. Thirty-seven PS samples from 11 South African paper and pulp mills exhibited large variation in chemical composition and resulting ethanol production. Simultaneous saccharification and fermentation (SSF) of PS in fed-batch culture was investigated at high solid loadings and low enzyme dosages. Water holding capacity and viscosity of the PS influenced ethanol production at elevated solid loadings of PS. High viscosity of PS from virgin pulp mills restricted the solid loading to 18% (w/w) at an enzyme dosage of 20 FPU/gram dry PS (gdPS), whereas an optimal solid loading of 27% (w/w) was achieved with corrugated recycle mill PS at 11 FPU/gdPS. Ethanol concentration and yield of virgin pulp and corrugated recycle PS were 34.2g/L at 66.9% and 45.5 g/L at 78.2%, respectively. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. A Myb transcription factor of Phytophthora sojae, regulated by MAP kinase PsSAK1, is required for zoospore development.

    Directory of Open Access Journals (Sweden)

    Meng Zhang

    Full Text Available PsSAK1, a mitogen-activated protein (MAP kinase from Phytophthora sojae, plays an important role in host infection and zoospore viability. However, the downstream mechanism of PsSAK1 remains unclear. In this study, the 3'-tag digital gene expression (DGE profiling method was applied to sequence the global transcriptional sequence of PsSAK1-silenced mutants during the cysts stage and 1.5 h after inoculation onto susceptible soybean leaf tissues. Compared with the gene expression levels of the recipient P. sojae strain, several candidates of Myb family were differentially expressed (up or down in response to the loss of PsSAK1, including of a R2R3-type Myb transcription factor, PsMYB1. qRT-PCR indicated that the transcriptional level of PsMYB1 decreased due to PsSAK1 silencing. The transcriptional level of PsMYB1 increased during sporulating hyphae, in germinated cysts, and early infection. Silencing of PsMYB1 results in three phenotypes: a no cleavage of the cytoplasm into uninucleate zoospores or release of normal zoospores, b direct germination of sporangia, and c afunction in zoospore-mediated plant infection. Our data indicate that the PsMYB1 transcription factor functions downstream of MAP kinase PsSAK1 and is required for zoospore development of P. sojae.

  16. PHOTOINHIBITION AND RECOVERY IN RELATION TO HETEROGENEITY OF PHOTOSYSTEM-II

    NARCIS (Netherlands)

    VANWIJK, KJ; SCHNETTGER, B; GRAF, M; KRAUSE, GH

    1993-01-01

    Photosystem II (PS II) heterogeneity during photoinhibition at 4-degrees-C and subsequent recovery at 20-degrees-C was investigated in spinach leaves and chloroplasts. The population of inactive, Q(B)-nonreducing centers was estimated by means of fluorescence induction in the presence of

  17. Association between presenilin-1 polymorphism and maternal meiosis II errors in Down syndrome.

    Science.gov (United States)

    Petersen, M B; Karadima, G; Samaritaki, M; Avramopoulos, D; Vassilopoulos, D; Mikkelsen, M

    2000-08-28

    Several lines of evidence suggest a shared genetic susceptibility to Down syndrome (DS) and Alzheimer disease (AD). Rare forms of autosomal-dominant AD are caused by mutations in the APP and presenilin genes (PS-1 and PS-2). The presenilin proteins have been localized to the nuclear membrane, kinetochores, and centrosomes, suggesting a function in chromosome segregation. A genetic association between a polymorphism in intron 8 of the PS-1 gene and AD has been described in some series, and an increased risk of AD has been reported in mothers of DS probands. We therefore studied 168 probands with free trisomy 21 of known parental and meiotic origin and their parents from a population-based material, by analyzing the intron 8 polymorphism in the PS-1 gene. An increased frequency of allele 1 in mothers with a meiosis II error (70.8%) was found compared with mothers with a meiosis I error (52.7%, P < 0.01), with an excess of the 11 genotype in the meiosis II mothers. The frequency of allele 1 in mothers carrying apolipoprotein E (APOE) epsilon4 allele (68.0%) was higher than in mothers without epsilon4 (52.2%, P < 0.01). We hypothesize that the PS-1 intronic polymorphism might be involved in chromosomal nondisjunction through an influence on the expression level of PS-1 or due to linkage disequilibrium with biologically relevant polymorphisms in or outside the PS-1 gene. Copyright 2000 Wiley-Liss, Inc.

  18. PS1-10jh CONTINUES TO FOLLOW THE FALLBACK ACCRETION RATE OF A TIDALLY DISRUPTED STAR

    Energy Technology Data Exchange (ETDEWEB)

    Gezari, S. [Department of Astronomy, University of Maryland, Stadium Drive, College Park, MD 20742-2421 (United States); Chornock, R. [Astrophysical Institute, Department of Physics and Astronomy, 251B Clippinger Lab, Ohio University Athens, OH 45701 (United States); Lawrence, A. [Institute for Astronomy, University of Edinburgh Scottish Universities Physics Alliance, Royal Observatory, Blackford Hill, Edinburgh EH9 3HJ (United Kingdom); Rest, A. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Jones, D. O. [Department of Physics and Astronomy, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); Berger, E.; Challis, P. M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Narayan, G., E-mail: suvi@astro.umd.edu [NOAO, 950 North Cherry Avenue, Tucson, AZ 85719 (United States)

    2015-12-10

    We present late-time observations of the tidal disruption event candidate PS1-10jh. UV and optical imaging with Hubble Space Telescope/WFC3 localize the transient to be coincident with the host galaxy nucleus to an accuracy of 0.023 arcsec, corresponding to 66 pc. The UV flux in the F225W filter, measured 3.35 rest-frame years after the peak of the nuclear flare, is consistent with a decline that continues to follow a t{sup −5/3} power-law with no spectral evolution. Late epochs of optical spectroscopy obtained with MMT ∼ 2 and 4 years after the peak, enable a clean subtraction of the host galaxy from the early spectra, revealing broad helium emission lines on top of a hot continuum, and placing stringent upper limits on the presence of hydrogen line emission. We do not measure Balmer Hδ absorption in the host galaxy that is strong enough to be indicative of a rare, post-starburst “E+A” galaxy as reported by Arcavi et al. The light curve of PS1-10jh over a baseline of 3.5 years is best modeled by fallback accretion of a tidally disrupted star. Its strong broad helium emission relative to hydrogen (He iiλ4686/Hα > 5) could be indicative of either the hydrogen-poor chemical composition of the disrupted star, or certain conditions in the tidal debris of a solar-composition star in the presence of an optically thick, extended reprocessing envelope.

  19. Validity and reliability of the Dutch adaptation of the Psoriatic Arthritis Quality of Life (PsAQoL Questionnaire.

    Directory of Open Access Journals (Sweden)

    Freke Wink

    Full Text Available OBJECTIVE: The Psoriatic Arthritis Quality of Life (PsAQoL questionnaire is a disease- specific instrument developed to measure quality of life (QoL in patients with psoriatic arthritis (PsA. The aim of this study was to translate the measure into Dutch and to determine its psychometric properties. METHOD: Translation of the original English PsAQoL into Dutch was performed by bilingual and lay panel. Ten field-test interviews with PsA patients were performed to assess face and content validity. In total, 211 PsA patients were included in a test-retest postal survey to investigate the reliability and construct validity of the Dutch adaptation of the PsAQoL. The PsAQoL, Health Assessment Questionnaire (HAQ and Skindex-17 were administered on two different occasions approximately two weeks apart. RESULTS: The Dutch version of the PsAQoL was found to be relevant, understandable and easy to complete in only a few minutes. It correlated as expected with the HAQ (Spearman's ρ = 0.72 and the 2 subscales of the Skindex-17 (ρ = 0.40 for the psychosocial and ρ = 0.46 for the symptom scale. Furthermore, the measure had good internal consistency (Cronbach's α = 0.92 and test-retest reliability (ρ = 0.89. The PsAQoL was able to define groups of patients based on self-reported general health status, self-reported severity of PsA and flare of arthritis. Duration of PsA did not influence PsAQoL scores. CONCLUSIONS: The Dutch version of the PsAQoL is a valid and reliable questionnaire suitable for use in clinical or research settings to asses PsA-specific QoL.

  20. Cartilage collagen type II seromarker patterns in axial spondyloarthritis and psoriatic arthritis

    DEFF Research Database (Denmark)

    Munk, Heidi Lausten; Gudmann, Natasja Staehr; Christensen, Anne Friesgaard

    2016-01-01

    The aim of the study was to assess the possible association between type II collagen turnover seromarkers and disease profile in patients with axial spondyloarthritis (SpA) and psoriatic arthritis (PsA). Outpatients with axial SpA (n = 110) or PsA (n = 101) underwent clinical examination including......-smokers, 0.43 ng/ml (p = 0.02), while PIIANP was higher in HLA-B27 positive, 2312 ng/ml versus negative patients, 2021 ng/ml (p = 0.03). In PsA, PIIANP and C2M did not differ between patients and controls, but PIIANP was elevated in patients not receiving DMARDs, 2726 ng/ml. In PsA, PIIANP and C2M did...... not differ according to smoking and HLA-B27. Cartilage degradation assessed by C2M is increased in SpA irrespective of treatment but not in PsA. Cartilage synthesis reflected by PIIANP is increased in untreated SpA and PsA. PIIANP correlates with CRP in SpA while not in PsA. In DMARD-naïve SpA but not in PsA...

  1. Seismic and Infrasound Location

    Energy Technology Data Exchange (ETDEWEB)

    Arrowsmith, Stephen J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Begnaud, Michael L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-03-19

    This presentation includes slides on Signal Propagation Through the Earth/Atmosphere Varies at Different Scales; 3D Seismic Models: RSTT; Ray Coverage (Pn); Source-Specific Station Corrections (SSSCs); RSTT Conclusions; SALSA3D (SAndia LoS Alamos) Global 3D Earth Model for Travel Time; Comparison of IDC SSSCs to RSTT Predictions; SALSA3D; Validation and Model Comparison; DSS Lines in the Siberian Platform; DSS Line CRA-4 Comparison; Travel Time Δak135; Travel Time Prediction Uncertainty; SALSA3D Conclusions; Infrasound Data Processing: An example event; Infrasound Data Processing: An example event; Infrasound Location; How does BISL work?; BISL: Application to the 2013 DPRK Test; and BISL: Ongoing Research.

  2. Demographics and remote locations

    Energy Technology Data Exchange (ETDEWEB)

    Coppus, G. [Dynawise Inc., Calgary, AB (Canada)

    2005-07-01

    Within the next decade, the number of people leaving the workforce will exceed the number of new entrants. The demand for workers is expected to increase in Alberta due to oil sands industry growth. Sixty-four per cent of all responding federal, provincial, and municipal government organizations have reported shortages in their work environments, and almost 8 in 10 organizations predict they will continue to be understaffed in the next 3 to 5 years. Tightness in the general labour market will have an impact on employers in remote locations, and planning is essential to avoid the creation of a mercenary culture and a reliance on compensation. Challenges found in remote locations include high turnover rates among recent hires; critical gaps in service length; aggressive retirement; and the fact that the local population is often seen as unqualified for many industrial jobs. This Power Point presentation suggested that although decisions to join or quit a company are often based on considerations such as the organizational environment and amount of compensation, the relationship between employees and management is the most important attribute in many career decisions. Rigorous quantitative analysis of current demographics combined with forecasting analysis may help to forestall recruitment difficulties for many companies. Productivity analyses, and the effects of work overload on absenteeism, attrition and quality of workmanship must also be examined. Many companies are now focusing on retention and development strategies on mid-career staff to address depletion, as well as redesigning procedures to operate with less skilled staff. It was concluded that extra efforts are now being made to attract non-traditional employees, and non-traditional employment models are being considered by some companies. refs., tabs., figs.

  3. Chronic Stress Contributes to Cognitive Dysfunction and Hippocampal Metabolic Abnormalities in APP/PS1 Mice

    Directory of Open Access Journals (Sweden)

    Bing Han

    2017-03-01

    Full Text Available Background/Aims: Stress response is determined by the brain, and the brain is a sensitive target for stress. Our previous experiments have confirmed that once the stress response is beyond the tolerable limit of the brain, particularly that of the hippocampus, it will have deleterious effects on hippocampal structure and function; however, the metabolic mechanisms for this are not well understood. Methods: Here, we used morris water maze, elisa and gas chromatography-time of flight/mass spectrometry to observe the changes in cognition, neuropathology and metabolomics in the hippocampus of APP/PS1 mice and wild-type (C57 mice caused by chronic unpredictable mild stress (CUMS, we also further explored the correlation between cognition and metabolomics. Results: We found that 4 weeks of CUMS aggravated cognitive impairment and increased amyloid-β deposition in APP/PS1 mice, but did not affect C57 mice. Under non-stress conditions, compared with C57 mice, there were 8 different metabolites in APP/PS1 mice. However, following CUMS, 3 different metabolites were changed compared with untreated C57 mice. Compared to APP/PS1 mice, there were 7 different metabolites in APP/PS1+CUMS mice. Among these alterations, 3-hydroxybutyric acid, valine, serine, beta-alanine and o-phosphorylethanolamine, which are involved in sphingolipid metabolism, synthesis and degradation of ketone bodies, and amino acid metabolism. Conclusion: The results indicate that APP/PS1 mice are more vulnerable to stress than C57 mice, and the metabolic mechanisms of stress-related cognitive impairment in APP/PS1 mice are related to multiple pathways and networks, including sphingolipid metabolism, synthesis and degradation of ketone bodies, and amino acid metabolism.

  4. Performance of a dual-process PVD/PS tungsten coating structure under deuterium ion irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyunmyung; Lee, Ho Jung; Kim, Sung Hwan [Department of Nuclear and Quantum Engineering, KAIST, Daejeon (Korea, Republic of); Song, Jae-Min [Department of Nuclear Engineering, Seoul National University, Seoul (Korea, Republic of); Jang, Changheui, E-mail: chjang@kaist.ac.kr [Department of Nuclear and Quantum Engineering, KAIST, Daejeon (Korea, Republic of)

    2016-11-01

    Highlights: • D{sup +} irradiation performance of a dual-process PVD/PS W coating was evaluated. • Low-energy plasmas exposure of 100 eV D{sup +} with 1.17 × 10{sup 21} D/s{sup −1} m{sup 2} flux was applied. • After D ion irradiation, flakes were observed on the surface of the simple PS coating. • While, sub-μm size protrusions were observed for dual-process PVD/PS W coating. • Height of D spike in depth profile was lower for dual-process PVD/PS W coating. - Abstract: A dual-process coating structure was developed on a graphite substrate to improve the performance of the coating structure under anticipated operating condition of fusion devices. A thin multilayer W/Mo coating (6 μm) was deposited by physical vapor deposition (PVD) method with a variation of Mo interlayer thickness on plasma spray (PS) W coating (160 μm) of a graphite substrate panel. The dual-process PVD/PS W coatings then were exposed to 3.08 × 10{sup 24} D m{sup −2} of 100 eV D ions with a flux of 1.71 × 10{sup 21} D m{sup −2} s{sup −1} in an electron cyclotron resonance (ECR) chamber. After irradiation, surface morphology and D depth profiles of the dual-process coating were analyzed and compared to those of the simple PS W coating. Both changes in surface morphology and D retention were strongly dependent on the microstructure of surface coating. Meanwhile, the existence of Mo interlayer seemed to have no significant effect on the retention of deuterium.

  5. (II) complexes

    African Journals Online (AJOL)

    activities of Schiff base tin (II) complexes. Neelofar1 ... Conclusion: All synthesized Schiff bases and their Tin (II) complexes showed high antimicrobial and ...... Singh HL. Synthesis and characterization of tin (II) complexes of fluorinated Schiff bases derived from amino acids. Spectrochim Acta Part A: Molec Biomolec.

  6. Endogenous unrestricted locations in markets with network effects

    OpenAIRE

    Ribeiro, Vitor

    2015-01-01

    The paper studies indirect network effects in a market composed by two incompatible intermediaries that choose price (short-term issue) in addition to location (long-term issue). The paper first shows that (i) when the network externality is sufficiently weak, only maximum differentiation prevails, (ii) the location equilibrium can be asymmetric for an intermediate level of the network externality, given that the first entrant locates at the city centre while the follower chooses an extreme (...

  7. Human iPS Cell-Derived Germ Cells: Current Status and Clinical Potential

    Directory of Open Access Journals (Sweden)

    Tetsuya Ishii

    2014-10-01

    Full Text Available Recently, fertile spermatozoa and oocytes were generated from mouse induced pluripotent (iPS cells using a combined in vitro and in vivo induction system. With regard to germ cell induction from human iPS cells, progress has been made particularly in the male germline, demonstrating in vitro generation of haploid, round spermatids. Although iPS-derived germ cells are expected to be developed to yield a form of assisted reproductive technology (ART that can address unmet reproductive needs, genetic and/or epigenetic instabilities abound in iPS cell generation and germ cell induction. In addition, there is still room to improve the induction protocol in the female germline. However, rapid advances in stem cell research are likely to make such obstacles surmountable, potentially translating induced germ cells into the clinical setting in the immediate future. This review examines the current status of the induction of germ cells from human iPS cells and discusses the clinical potential, as well as future directions.

  8. Structure-properties relationships of polyhedral oligomeric silsesquioxane (POSS filled PS nanocomposites

    Directory of Open Access Journals (Sweden)

    J. J. Schwab

    2012-07-01

    Full Text Available The polyhedral oligomeric silsesquioxane (POSS additivated polystyrene (PS based nanocomposites were prepared by melt processing and the structure-properties relationships of the POSS-PS systems were compared to those of the neat PS. In order to investigate the effect of these structural parameters on the final properties of the polymer nanocomposites, five different kinds of POSS samples were used, in particular, POSS with different inorganic cage and with different organic pendent groups. The rheological investigation suggests clearly that the POSS acts as a plasticizer and that the processability of the PS was positively modified. The affinity between the POSS samples and the PS matrix was estimated by the calculated theoretical solubility parameters, considering the Hoy’s method and by morphology analysis. Minor difference between the solubility parameter of POSS and the matrix means better compatibility and no aggregation tendency. Furthermore, the POSS loading leads to a decrease of the rigidity, of the glass transition temperature and of the damping factor of the nanocomposite systems. The loading of different POSS molecules with open cage leads to a more pronounced effect on all the investigated properties that the loading of the POSS molecules with closed cage. Moreover, the melt properties are significantly influenced by the type of inorganic framework, by the type of the pendent organic groups and by the interaction between the POSS organic groups and the host matrix, while, the solid state properties appears to be influenced more by the kind of cage.

  9. PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists.

    Science.gov (United States)

    Canfield, C J; Milhous, W K; Ager, A L; Rossan, R N; Sweeney, T R; Lewis, N J; Jacobus, D P

    1993-07-01

    A new, orally-active inhibitor of dihydrofolic acid reductase (DHFR), PS-15 (N-(3-(2,4,5-trichlorophenoxy)propyloxy)-N'-(1-methylethyl)- imidocarbonimidic diamide hydrochloride), has significant activity against drug-resistant Plasmodium falciparum. It is not cross-resistant with other inhibitors of DHFR (e.g., pyrimethamine and cycloguanil). Although it bears similarities to proguanil, PS-15 represents a new antifolate class of drugs that we have named oxyguanils or hydroxylamine-derived biguanides. This compound displays intrinsic antimalarial activity and also is metabolized in vivo to WR99210, an extremely active triazine inhibitor of DHFR. When tested in vitro against drug-resistant clones of P. falciparum, PS-15 was more active than proguanil, and the putative metabolite, WR99210, was more active than the proguanil metabolite cycloguanil. The drug is also more active as well as less toxic than proguanil when administered orally to mice infected with P. berghei. When administered orally to Aotus monkeys infected with multidrug-resistant P. falciparum, PS-15 was more active than either proguanil or WR99210. In 1973, WR99210 underwent clinical trials for safety and tolerance in volunteers. The trials showed gastrointestinal intolerance and limited bioavailability; further development of the drug was abandoned. Because PS-15 has intrinsic antimalarial activity, is not cross-resistant with other DHFR inhibitors, and can be metabolized to WR99210 in vivo, oral administration of this new drug should circumvent the shortcomings and retain the advantages found with both proguanil and WR99210.

  10. Contribution of defective PS recognition and efferocytosis to chronic inflammation and autoimmunity

    Directory of Open Access Journals (Sweden)

    Stanley Gititu Kimani

    2014-11-01

    Full Text Available Rapid and efficient clearance of apoptotic cells results in elimination of auto-antigens and provides a strong anti-inflammatory and immunosuppressive signal to prevent autoimmunity. While professional and non-professional phagocytes utilize a wide array of surface receptors to recognize apoptotic cells, recognition of phosphatidylserine (PS on apoptotic cells by PS receptors on phagocytes is emblematic signal for efferocytosis in metazoans. PS-dependent efferocytosis is associated with production of anti-inflammatory factors such as IL-10 and TGF-β that function, in part, to maintain tolerance to auto-antigens. In contrast, when apoptotic cells fail to be recognized and processed for degradation, auto-antigens persist, which can trigger immune activation leading to autoantibody production and autoimmunity. Despite the fact that genetic mouse models clearly demonstrate that loss of PS receptors can lead to age-dependent autoimmune diseases reminiscent of systemic lupus erythematosus (SLE, link between PS and defective clearance in chronic inflammation and human autoimmunity is not well delineated. In this hypothesis and theory, we review emerging questions developing in the field that may be of relevance to SLE and human autoimmunity.

  11. Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice

    Energy Technology Data Exchange (ETDEWEB)

    Dhenain, M. [URA CEA CNRS 2210, I2BM, SHFJ, 4 Place du General Leclerc, 91401 Orsay Cedex (France); Dhenain, M.; El Tannir El Tayara, N.; Wu, T.D.; Volk, A.; Quintana, C. [U759 INSERM, Centre Universitaire, Laboratoire 112, 91405 Orsay Cedex (France); Dhenain, M.; El Tannir El Tayara, N.; Wu, T.D.; Volk, A.; Quintana, C. [Institut Curie, Centre Universitaire, Laboratoire 112, 91405 Orsay Cedex (France); Guegan, M.; Delatour, B. [Instituto de Microelectronica de Madrid-CSIC, 8, Isaac Newton, 28760 Tres Cantos, Madrid (Spain)

    2009-07-01

    Amyloid deposits are one of the hallmarks of Alzheimer's disease. Recent studies, in transgenic mice modeling Alzheimer's disease showed that, using in vivo, contrast agent-free, MRI, thalamic amyloid plaques are more easily detected than other plaques of the brain. Our study evaluated the characteristics of these thalamic plaques in a large population of APP/PS1, PS1 and C57BL/6 mice. Thalamic spots were detected in all mice but with different frequency and magnitude. Hence, the prevalence and size of the lesions were higher in APP/PS1 mice. However, even in APP/PS1 mice, thalamic spots did not occur in all the old animals. In APP/PS1 mice, spots detection was related to high iron and calcium load within amyloid plaques and thus reflects the ability of such plaque to capture large amounts of minerals. Interestingly, calcium and iron was also detected in extra-thalamic plaques but with a lower intensity. Hypointense lesions in the thalamus were not associated with the iron load in the tissue surrounding the plaques, nor with micro-hemorrhages, inflammation, or a neuro-degenerative context. (authors)

  12. Nouvelle application de control des cavités 200 MHz RF du PS (CERN)

    CERN Document Server

    Cotte, D

    2011-01-01

    Le système Radio Fréquence (RF) 200MHz du PS est un outil essentiel pour la préparation des faisceaux haute intensité du PS. Dans l’anneau PS on trouve 6 cavités 200 MHz utilisées pour contrôler : • l’émittance longitudinale des « bunches » • le processus de « Rebunching » du faisceau avant de l’envoyer au SPS. Chaque cavité est pilotée par des événements appelés « timing » et suit une fonction de tension programmée. Cependant, l’électronique utilisée pour piloter les cavités 200 MHz du PS est obsolète et sa fiabilité non garantie pour cause du manque de pièces de rechange. Ce document décrit le fonctionnement du nouveau programme d’application qui fait abstraction de l’ancienne matrice hardware. Elle suit les recommandations décrites dans l’étude d’une nouvelle structure pour le système RF 200MHz du PS. [1

  13. The development of the Asian Forum for Polar Sciences (AFoPS)

    Science.gov (United States)

    Kim, Yeadong; Jeong, Jihoon

    2015-12-01

    The Asian Forum for Polar Sciences (AFoPS), an international forum of Asian polar research institutes, was established for the advancement of polar sciences among its members in 2004. The Forum has served as an important medium of Asian collective endeavors for polar affairs in human and information exchange, research collaboration, and logistics cooperation for the last decade. The historical development of the AFoPS in retrospect can be divided into four phases: inception and establishment (2003-2004), growth and expansion (2005-2007), review and restructuring (2008-2011), and achievements and further measures (2012-2014). The progress of the AFoPS has not been linear and this trend will continue into the next decades. The Forum, however, clearly made achievements in this period of time, realizing multilateral research and logistics cooperation that would have been previously unimaginable; by doing so, it has laid the foundation for the future. Responsible for a great portion of the world's polar activities, the AFoPS will rise to meet the expectations of the world by producing notable research output, initiating international cooperative programs, and supporting non-polar Asian countries with education and research collaboration. These are the tasks of the AFoPS for the next decade and they require strategy that promotes and facilitates collaboration in a practical way and draws attention of non-polar Asian countries to the polar sciences.

  14. Location constrained resource interconnection

    International Nuclear Information System (INIS)

    Hawkins, D.

    2008-01-01

    This presentation discussed issues related to wind integration from the perspective of the California Independent System Operator (ISO). Issues related to transmission, reliability, and forecasting were reviewed. Renewable energy sources currently used by the ISO were listed, and details of a new transmission financing plan designed to address the location constraints of renewable energy sources and provide for new transmission infrastructure was presented. The financing mechanism will be financed by participating transmission owners through revenue requirements. New transmission interconnections will include network facilities and generator tie-lines. Tariff revisions have also been implemented to recover the costs of new facilities and generators. The new transmission project will permit wholesale transmission access to areas where there are significant energy resources that are not transportable. A rate impact cap of 15 per cent will be imposed on transmission owners to mitigate short-term costs to ratepayers. The presentation also outlined energy resource area designation plans, renewable energy forecasts, and new wind technologies. Ramping issues were also discussed. It was concluded that the ISO expects to ensure that 20 per cent of its energy will be derived from renewable energy sources. tabs., figs

  15. On location at CERN

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    CERN continues to be a very popular candidate for film locations at the moment. Not only has it inspired a German author and a film-maker interested in the more exotic interpretations of the science being worked on at the Organization, but even the recent puppet animation film by the legendary Muppets featured some CERN scenes.   Dr Bunsen Honeydew (far left) and his friends at ATLAS. Beaker, Bunsen's assistant, has just been sucked up the vacuum tube top left... Image courtesy Walt Disney Studios. In “The Muppet Movie”, released in November 2011 in North America and world-wide in January and February this year, Kermit is reuniting his friends who have ended up in some far-flung places since they last worked together 10 years ago. CERN caught the imagination of the film-makers as the perfect place for the Muppet scientists, Dr. Honeydew Bunsen and his hapless assistant Beaker. After a brief scene filmed in front of a backdrop of the ATLAS detector, the rest of the ...

  16. Probability-of-Superiority SEM (PS-SEM—Detecting Probability-Based Multivariate Relationships in Behavioral Research

    Directory of Open Access Journals (Sweden)

    Johnson Ching-Hong Li

    2018-06-01

    Full Text Available In behavioral research, exploring bivariate relationships between variables X and Y based on the concept of probability-of-superiority (PS has received increasing attention. Unlike the conventional, linear-based bivariate relationship (e.g., Pearson's correlation, PS defines that X and Y can be related based on their likelihood—e.g., a student who is above mean in SAT has 63% likelihood of achieving an above-mean college GPA. Despite its increasing attention, the concept of PS is restricted to a simple bivariate scenario (X-Y pair, which hinders the development and application of PS in popular multivariate modeling such as structural equation modeling (SEM. Therefore, this study addresses an empirical-based simulation study that explores the potential of detecting PS-based relationship in SEM, called PS-SEM. The simulation results showed that the proposed PS-SEM method can detect and identify PS-based when data follow PS-based relationships, thereby providing a useful method for researchers to explore PS-based SEM in their studies. Conclusions, implications, and future directions based on the findings are also discussed.

  17. Risk Management Capability Maturity and Performance of Complex Product and System (CoPS Projects with an Asian Perspective

    Directory of Open Access Journals (Sweden)

    Ren, Y.

    2014-07-01

    Full Text Available Complex Products and Systems (CoPS are high value, technology and engineering-intensive capital goods. The motivation of this study is the persistent high failure rate of CoPS projects, Asian CoPS provider’s weak capability and lack of specific research on CoPS risk management. This paper evaluates risk management maturity level of CoPS projects against a general CoPS risk management capability maturity model (RM-CMM developed by the authors. An Asian based survey was conducted to investigate the value of RM to project performance, and Asian (non-Japanese CoPS implementers’ perceived application of RM practices, their strengths and weaknesses. The survey result shows that higher RM maturity level leads to higher CoPS project performance. It also shows project complexity and uncertainty moderates the relationship between some RM practices and project performance, which implies that a contingency approach should be adopted to manage CoPS risks effectively. In addition, it shows that Asian CoPS implementers are weak in RM process and there are also rooms for improvement in the softer aspects of organizational capabilities and robustness.

  18. Incineration experiences at the Tsuruga P.S. and outline of the advanced type incineration system at the Tokai No. 2 P.S

    International Nuclear Information System (INIS)

    Yui, K.; Kurihara, Y.; Inoue, S.; Takamori, H.; Karita, Y.

    1987-01-01

    In 1978, the first radwaste incineration plant among Japanese nuclear power stations started its operation at Tsuruga P.S., and the first advanced radwaste incineration plant has been constructed and accomplished the test operation in September 1986. This paper describes the outline of Tsuruga incineration plant and its operation achievements, and the outline of advanced incineration technology, Tokai No. 2 incineration plant and its test operation results

  19. Costly location in Hotelling duopoly

    NARCIS (Netherlands)

    Hinloopen, J.; Martin, S.

    2013-01-01

    We introduce a cost of location into Hotelling’s (1929) spatial duopoly. We derive the general conditions on the cost-of-location function under which a pure strategy price-location Nash equilibrium exists. With linear transportation cost and a suitably specified cost of location that rises toward

  20. Costly location in Hotelling duopoly

    NARCIS (Netherlands)

    Hinloopen, J.; Martin, S.

    We introduce a cost of location into Hotelling's (1929) spatial duopoly model. We derive the general conditions on the cost-of-location function under which a pure strategy price-location Nash equilibrium exists. With linear transportation cost and a suitably specified cost of location that rises

  1. Experiments at the KEK 12-GeV PS in 1991-1995

    International Nuclear Information System (INIS)

    Yoshimura, Y.

    1994-06-01

    This report has been edited mainly to introduce the various activities at the KEK 12-GeV PS. Chapter 1 is a list of experiments which have been approved by the PS-PAC since May 2, 1975. The machine time executed from FY 1990 to Fy 1993 is shown in chapter 2. In chapter 4, experiments which are currently in various stages of preparation, running and data analyzing are briefly described. The information was extracted from the 'KEK-PS Proposal', 'KEK Annual Report 1990-1993' and various published papers listed in chapter 5. In the descriptions the author sometimes might give 'sensitive' information concerning the experimental groups very directly. Readers of this publication are therefore requested not to directly quote the descriptions given in chapter 4. (J.P.N.)

  2. Thermodynamics parameters of nano-Ni/PS composites prepared by in situ polymerization method

    International Nuclear Information System (INIS)

    Liao Qilong; Xiong Jie; Ning Haixia

    2011-01-01

    Spherical nickel nanoparticles with about 75∼200 nm in size were obtained by a liquid reduction method. The nickel nanoparticles/PS composites were synthesized via in situ polymerization method. XRD, FTIR, SEM and TG-DSC were respectively used to measure the properties of nickel nanoparticles, the microstructure of as-prepared composites samples, the distribution of nickel nanoparticles in PS and the thermodynamic parameters of as-prepared composites. The results show that the nickel nanoparticles will enhance the glass transition temperature of nano-Ni/PS composites. The enthalpy of composites is heightened by increasing of doping dose, and it reaches the top when the doping dose is from 1% to 2%. The specific heat of the composites will reduce with the doping dose of nickel nanoparticles increasing. (authors)

  3. Nanoporous polymeric nanofibers based on selectively etched PS-b-PDMS block copolymers.

    Science.gov (United States)

    Demirel, Gokcen B; Buyukserin, Fatih; Morris, Michael A; Demirel, Gokhan

    2012-01-01

    One-dimensional nanoporous polymeric nanofibers have been fabricated within an anodic aluminum oxide (AAO) membrane by a facile approach based on selective etching of poly(dimethylsiloxane) (PDMS) domains in polystyrene-block-poly(dimethylsiloxane) (PS-b-PDMS) block copolymers that had been formed within the AAO template. It was observed that prior to etching, the well-ordered PS-b-PDMS nanofibers are solid and do not have any porosity. The postetched PS nanofibers, on the other hand, had a highly porous structure having about 20-50 nm pore size. The nanoporous polymeric fibers were also employed as a drug carrier for the native, continuous, and pulsatile drug release using Rhodamine B (RB) as a model drug. These studies showed that enhanced drug release and tunable drug dosage can be achieved by using ultrasound irradiation. © 2011 American Chemical Society

  4. Age-related location of manifest accessory pathway and clinical consequences.

    Science.gov (United States)

    Brembilla-Perrot, Béatrice; Huttin, Olivier; Olivier, Arnaud; Sellal, Jean Marc; Villemin, Thibaut; Manenti, Vladimir; Moulin-Zinsch, Anne; Marçon, François; Simon, Gauthier; Andronache, Marius; Beurrier, Daniel; de Chillou, Christian; Girerd, Nicolas

    2015-01-01

    Accessory pathway (AP) ablation is not always easy. Our purpose was to assess the age-related prevalence of AP location, electrophysiological and prognostic data according to this location. Electrophysiologic study (EPS) was performed in 994 patients for a pre-excitation syndrome. AP location was determined on a 12 lead ECG during atrial pacing at maximal preexcitation and confirmed at intracardiac EPS in 494 patients. AP location was classified as anteroseptal (AS)(96), right lateral (RL)(54), posteroseptal (PS)(459), left lateral (LL)(363), nodoventricular (NV)(22). Patients with ASAP or RLAP were younger than patients with another AP location. Poorly-tolerated arrhythmias were more frequent in patients with LLAP than in other patients (0.009 for ASAP, 0.0037 for RLAP, location was confirmed at intracardiac EPS. Among untreated patients, poorly-tolerated arrhythmia occurred in patients with LLAP (3) or PSAP (6). Failures of ablation were more frequent for AS or RL AP than for LL or PS AP. AS and RLAP location in pre-excitation syndrome was more frequent in young patients. Maximal rate conducted over AP was lower than in other locations. Absence of poorly-tolerated arrhythmias during follow-up and higher risk of ablation failure should be taken into account for indications of AP ablation in children with few symptoms.

  5. PsOr1, a potential target for RNA interference-based pest management.

    Science.gov (United States)

    Zhao, Y Y; Liu, F; Yang, G; You, M S

    2011-02-01

    Insect pests cause billions of dollars in agricultural losses, and attempts to kill them have resulted in growing threats from insecticide resistance, dietary pesticide pollution and environmental destruction. New approaches to control refractory insect pests are therefore needed. The host-plant preferences of insect pests rely on olfaction and are mediated via a seven transmembrane-domain odorant receptor (Or) family. The present study reports the cloning and characterization of PsOr1, the first candidate member of the Or gene family from Phyllotreta striolata, a devastating beetle pest that causes damage worldwide. PsOr1 is remarkably well conserved with respect to other insect orthologues, including DmOr83b from Drosophila melanogaster. These insect orthologues form an essential non-conventional Or sub-family and may play an important and generalized role in insect olfaction. We designed double-stranded (ds) RNA directly against the PsOr1 gene and exploited RNA interference (RNAi) to control P. striolata. The chemotactic behavioural measurements showed that adult beetles were unable to sense the attractant or repellent odour stimulus after microinjection of dsRNA against PsOr1. Reverse Transcription (RT)-PCR analysis showed specific down-regulation of mRNA transcript levels for this gene. Furthermore, host-plant preference experiments confirmed that silencing PsOr1 by RNAi treatment impaired the host-plant preferences of P. striolata for cruciferous vegetables. These results demonstrate that this insect control approach of using RNAi to target PsOr1 and its orthologues might be effective in blocking host-plant-seeking behaviours in diverse insect pests. The results also support the theory that this unique receptor type plays an essential general role in insect olfaction. © 2010 Fujian Agriculture and Forestry University. Insect Molecular Biology © 2010 The Royal Entomological Society.

  6. PS-b-PMMA/PLA blends for nanoporous templates with hierarchical and tunable pore size

    Science.gov (United States)

    Nguyen, Thi-Hoa; Vayer, Marylène; Sinturel, Christophe

    2018-01-01

    Blends of poly(styrene)-block-poly(methyl methacrylate) (PS-b-PMMA) and poly(lactide) (PLA) were deposited in the form of thin films on the surface of modified silicon wafers and exposed to tetrahydrofuran (THF) vapor annealing. It was shown that in specific experimental conditions, a core-shell morphology consisting in cylinders with a PMMA shell and a PLA core, within a continuous matrix of PS, was formed. In this case, PLA naturally segregated in the core of the PMMA cylinders, minimizing the PS/PLA interaction, which constitutes the most incompatible pair (the interaction strength between the various components was confirmed in thin films of the corresponding polymer blends). Compared to other block copolymer/homopolymer blends described in the literature, this system exhibits unexpected high increase of the characteristic lengths of the system (center-to-center distance and diameter). This was attributed to a partial solubilization of the PLA in the PMMA corona (the two polymers are highly compatible), inducing an enhanced level of PS and PLA stretching caused by the strong repulsion between these two polymers. The selective extraction of the PLA yielded to porous domains with small dimensions (6 ± 2.5 nm), reaching the performances that are currently attained in highly incompatible block polymers with low molecular weight. Further PMMA removal revealed a second porosity level, with higher pores diameter and center-to-center distance compared to the neat PS-b-PMMA system. This work highlights how PS-b-PMMA, that currently represents one of the industrial standards nanoporous template precursors, can be modified in an easy and costless approach using PLA homopolymer addition.

  7. Induction of host defences by Rhizobium during ineffective nodulation of pea (Pisum sativum L.) carrying symbiotically defective mutations sym40 (PsEFD), sym33 (PsIPD3/PsCYCLOPS) and sym42.

    Science.gov (United States)

    Ivanova, Kira A; Tsyganova, Anna V; Brewin, Nicholas J; Tikhonovich, Igor A; Tsyganov, Viktor E

    2015-11-01

    Rhizobia are able to establish a beneficial interaction with legumes by forming a new organ, called the symbiotic root nodule, which is a unique ecological niche for rhizobial nitrogen fixation. Rhizobial infection has many similarities with pathogenic infection and induction of defence responses accompanies both interactions, but defence responses are induced to a lesser extent during rhizobial infection. However, strong defence responses may result from incompatible interactions between legumes and rhizobia due to a mutation in either macro- or microsymbiont. The aim of this research was to analyse different plant defence reactions in response to Rhizobium infection for several pea (Pisum sativum) mutants that result in ineffective symbiosis. Pea mutants were examined by histochemical and immunocytochemical analyses, light, fluorescence and transmission electron microscopy and quantitative real-time PCR gene expression analysis. It was observed that mutations in pea symbiotic genes sym33 (PsIPD3/PsCYCLOPS encoding a transcriptional factor) and sym40 (PsEFD encoding a putative negative regulator of the cytokinin response) led to suberin depositions in ineffective nodules, and in the sym42 there were callose depositions in infection thread (IT) and host cell walls. The increase in deposition of unesterified pectin in IT walls was observed for mutants in the sym33 and sym42; for mutant in the sym42, unesterified pectin was also found around degrading bacteroids. In mutants in the genes sym33 and sym40, an increase in the expression level of a gene encoding peroxidase was observed. In the genes sym40 and sym42, an increase in the expression levels of genes encoding a marker of hypersensitive reaction and PR10 protein was demonstrated. Thus, a range of plant defence responses like suberisation, callose and unesterified pectin deposition as well as activation of defence genes can be triggered by different pea single mutations that cause perception of an otherwise

  8. Character of the contact and biostratigraphical feature of distribution of the microfauna on border between productive series (PS) and underlying upper Miocene sediments of Absheron oil and gas bearing region

    International Nuclear Information System (INIS)

    Shikhlinsky, S.A.

    2002-01-01

    Full text: Productive Series (PS) is a basic hydrocarbon object and has a wide distribution in the Absheron Oil and Gas Bearing Region (AOGBR).In the normal stratigraphic sequences PS lays between Akchagylian and Pontian Regiostages (Pontian).From microfauna point of view, PS contains rare native ostracods , fish teeth, otolithes and forams.In situ, in PS, there are 34 of microfauna species present and more than half of them are transitional, which appear in the Upper Miocene and finish the existence in the Akchagylian-Apsheronian sediments.Others taxons are having the strict stratigraphical distribution and very important for the definition of the age of different lithostratones inside PS.Stratigraphical distribution of these species has been tested in numerous natural outcrops and well sections.The large interest for geologists is the boundary between PS and underlying Upper Miocene.The stratigraphic character of the given intermediate complex of sediments depends on paleotectonic conditions and different sections on the way it is expressed differently.In one section, in other-the gradual transition from Pontian to Kalinskaya Suite (KaS).The detailed study of the samples from the numerous old explorationwells drilled before 1972 and from new contract areas located in the Caspian sea, such as Karabakh, Dan Ulduzu, Ashrafi, where sampling was made very detailed, allowed us to discover the characteristic biomarkers and to specify the character of distribution of the microfauna on the Pontian-KaS boundary.The similar contact between KaC and Pontian is observed in the Karabakh field too.KaS here is represented by monotonous carbonated shale, clay and claystone, almost not distinguished from the black Potian shale, with increase at the contact with water.Despite of it, the boundary is precisely beaten by microfauna.In the Pontian sediments we have discovered a characteristic complex of Ostracoda and microscopic Pelecypoda.

  9. GP pain management: what are the 'Ps' and 'As' of pain management?

    Science.gov (United States)

    Wan, Aston

    2014-08-01

    Pain is one common reason for clinical encounters in primary care. The complex nature of chronic pain syndromes can make assessment and management daunting at times. This article presents an easy scheme to help general practitioners efficiently assess, manage and review/follow up patients with chronic pain. The mnemonic presented for assessment is the '4Ps' (pain, other pathology/past medical history, performance/function and psychological/psychiatric status). For management, we can also use '4Ps' (physical, psychological, pharmacological and procedural) and for review there are the '6As' (activities, analgesia, adverse effects, aberrance behaviours, affects and adequate documentation).

  10. The Automatic Test Features of the IDiPS Reactor Protection System

    International Nuclear Information System (INIS)

    Hur, Seop; Kim, Dong-Hoon; Hwang, In-Koo; Lee, Cheol-Kwon; Lee, Dong-Young

    2007-01-01

    The reactor protection system (RPS) is designed to minimize a propagation of abnormal or accident conditions of nuclear power plants. A digital RPS (Integrated Digital Protection System (IDiPS) RPS) is being developed in the Korea Nuclear Instrumentation and Control System (KNICS) R and D project. To make good use of the advantages of the digital technology, it is necessary to improve the reliability and availability of a system through automatic test features including an on-line testing, a self-diagnostics, an auto calibration, etc. This paper summarizes the system test strategy and the automatic test features of the IDiPS RPS

  11. Simulation of Instability at Transition Energy with a New Impedance Model for CERN PS

    CERN Document Server

    Wang, Na; Biancacci, Nicolo; Migliorati, Mauro; Persichelli, Serena; Sterbini, Guido

    2016-01-01

    Instabilities driven by the transverse impedance are proven to be one of the limitations for the high intensity reach of the CERN PS. Since several years, fast single bunch vertical instability at transition energy has been observed with the high intensity bunch serving the neu-tron Time-of-Flight facility (n-ToF). In order to better understand the instability mechanism, a dedicated meas-urement campaign took place. The results were compared with macro-particle simulations with PyHEADTAIL based on the new impedance model developed for the PS. Instability threshold and growth rate for different longitu-dinal emittances and beam intensities were studied.

  12. Comparison of soft and hard tissue ablation with sub-ps and ns pulse lasers

    Energy Technology Data Exchange (ETDEWEB)

    Da Silva, L.B.; Stuart, B.C.; Celliers, P.M.; Feit, M.D.; Glinsky, M.E.; Heredia, N.J.; Herman, S.; Lane, S.M.; London, R.A.; Matthews, D.L.; Perry, M.D.; Rubenchik, A.M. [Lawrence Livermore National Lab., CA (United States); Chang, T.D. [Veterans Administration Hospital, Martinez, CA (United States); Neev, J. [Beckman Laser Inst. and Medical Clinic, Irvine, CA (United States)

    1996-05-01

    Tissue ablation with ultrashort laser pulses offers several unique advantages. The nonlinear energy deposition is insensitive to tissue type, allowing this tool to be used for soft and hard tissue ablation. The localized energy deposition lead to precise ablation depth and minimal collateral damage. This paper reports on efforts to study and demonstrate tissue ablation using an ultrashort pulse laser. Ablation efficiency and extent of collateral damage for 0.3 ps and 1000 ps duration laser pulses are compared. Temperature measurements of the rear surface of a tooth section is also presented.

  13. Generation of iPS cell lines from schizophrenia patients using a non-integrative method

    Directory of Open Access Journals (Sweden)

    Jaroslaw Sochacki

    2016-07-01

    Full Text Available Skin biopsies were collected from three male patients (age 45, 44 and 44 with clinically diagnosed schizophrenia. The patients were diagnosed according to DSM-5 criteria by a trained psychiatrist. Dermal fibroblast cell lines were established and expanded for subsequent reprogramming procedures. Induced pluripotent stem (iPS cells were derived using the integration-free CytoTune®-iPS 2.0 Sendai Reprogramming Kit, containing Sendai virus particles of the four Yamanaka factors Oct3/4, Sox2, Klf4 and c-Myc.

  14. A multichannel time-to-digital converter ASIC with better than 3 ps RMS time resolution

    International Nuclear Information System (INIS)

    Perktold, L; Christiansen, J

    2014-01-01

    The development of a new multichannel, fine-time resolution time-to-digital converter (TDC) ASIC is currently under development at CERN. A prototype TDC has been designed, fabricated and successfully verified with demonstrated time resolutions of better than 3 ps-rms. Least-significant-bit (LSB) sizes as small as 5 ps with a differential-non-linearity (DNL) of better than ±0.9 LSB and integral-non-linearity (INL) of better than ±1.3 LSB respectively have been achieved. The contribution describes the implemented architecture and presents measurement results of a prototype ASIC implemented in a commercial 130 nm technology

  15. Raising the 3Ps of Sustainable Facilities Management in Singapore – Profession, Perception and Prospection

    OpenAIRE

    Thoo, S. L.; Marjanovic-Halburd, L.

    2015-01-01

    The purpose of this study is to determine if the target set by Singapore’s Inter-Ministerial Committee for Sustainable Development to have 80% of the buildings at least Green Mark certified by 2030 has any impact on raising the profession, perception and prospection (3Ps) of Sustainable Facilities Management (SFM) in Singapore. The objectives are to understand the tertiary students’ choice of study, determine the core knowledge for SFM, compare the pre-existing 3Ps of Tertiary Students (TS) a...

  16. Status of the anti-proton production beam in the CERN PS

    International Nuclear Information System (INIS)

    Cappi, R.; Evans, B.J.; Garoby, R.

    1990-01-01

    A new scheme was put into operation in November 1988 to upgrade the proton beam delivered by the 26 GeV Proton Synchrotron (PS) for anti-proton production. It makes use of quasi-adiabatic manipulations of the RF parameters to squeeze a beam filling 1/2 of the PS circumference into a 1/4 turn and can in theory preserve the longitudinal emittance. A maximum intensity of 1.68 e 13 ppp in 5 bunches at 26 GeV has been reached in the course of 22 weeks of operation. The limitations of the performance are analysed together with possible improvements. (author) 6 refs., 9 figs

  17. Experiments at the 12 GeV PS in 1986 - 1990

    International Nuclear Information System (INIS)

    Yoshimura, Y.

    1990-12-01

    This book has been edited mainly to introduce the various activities at the KEK 12 GeV PS. In the chapter 4, experiments which are currently in the stages of preparation, running and data analyzing are briefly described using information extracted from the 'KEK PS Proposal', 'KEK Annual Report 1986-1989' and various published papers listed in chapter 5. In the descriptions the author sometimes gives 'sensitive' information concerning the experimental groups very directly. Readers of this publication are therefore requested not to directly quote the descriptions given in chapter 4 (since that information was not provided by them). (author)

  18. Rejuvenation of the controls of the CERN PS/ISOLDE facility using industrial components

    CERN Document Server

    Allard, J.; Locci, F.; Mornacchi, G.

    2001-01-01

    In the context of the general consolidation of the CERN ISOLDE facility, a project has been started to upgrade the ISOLDE control system. We describe the new ISOLDE control system, emphasizing the systematic use of industrial components such as PLCs and field buses, their integration with the existing, VME based, CERN PS control system and their potential applicability to both existing and new controls problems at the CERN PS complex. We also discuss how to extend a PLC-based solution to the case where real-time response is an issue.

  19. Status of the maintenance for the KEK 12GEV-PS main ring and power supply

    International Nuclear Information System (INIS)

    Sato, Hikaru; Igarashi, Susumu; Marutsuka, Katsumi; Mikawa, Katsuhiko; Shirakata, Masashi; Sueno, Tsuyoshi; Tokuda, Noboru

    2004-01-01

    More than 30 years passed since the KEK 12GeV-PS construction, some of accelerator equipments are highly radiated, especially the injection and the extraction equipments. In recent years, the higher intensity beam has been required for such as the long baseline neutrino oscillation experiment and rare decay experiments. Then, the circumference of the maintenance work has become severe. Further, almost equipments of main ring and power supply have deteriorated. Status of the Maintenance for the KEK 12GeV-PS main ring and power supply are presented. (author)

  20. Magnetic behavior of MnPS3 phases intercalated by [Zn2L]2+ (LH2: macrocyclic ligand obtained by condensation of 2-hydroxy-5-methyl-1,3-benzenedicarbaldehyde and 1,2-diaminobenzene)

    International Nuclear Information System (INIS)

    Spodine, E.; Valencia-Galvez, P.; Fuentealba, P.; Manzur, J.; Ruiz, D.; Venegas-Yazigi, D.; Paredes-Garcia, V.; Cardoso-Gil, R.; Schnelle, W.; Kniep, R.

    2011-01-01

    The intercalation of the cationic binuclear macrocyclic complex [Zn 2 L] 2+ (LH 2 : macrocyclic ligand obtained by the template condensation of 2-hydroxy-5-methyl-1,3-benzenedicarbaldehyde and 1,2-diaminobenzene) was achieved by a cationic exchange process, using K 0.4 Mn 0.8 PS 3 as a precursor. Three intercalated materials were obtained and characterized: (Zn 2 L) 0.05 K 0.3 Mn 0.8 PS 3 (1), (Zn 2 L) 0.1 K 0.2 Mn 0.8 PS 3 (2) and (Zn 2 L) 0.05 K 0.3 Mn 0.8 PS 3 (3), the latter phase being obtained by an assisted microwave radiation process. The magnetic data permit to estimate the Weiss temperature θ of ∼-130 K for (1); ∼-155 K for (2) and ∼-130 K for (3). The spin canting present in the potassium precursor remains unperturbed in composite (3), and spontaneous magnetization is observed under 50 K in both materials. However composites (1) and (2) do not present this spontaneous magnetization at low temperatures. The electronic properties of the intercalates do not appear to be significantly altered. The reflectance spectra of the intercalated phases (1), (2) and (3) show a gap value between 1.90 and 1.80 eV, lower than the value observed for the K 0.4 Mn 0.8 PS 3 precursor of 2.8 eV. -- Graphical Abstract: Microwave assisted synthesis was used to obtain an intercalated MnPS 3 phase with a binuclear Zn(II) macrocyclic complex. A comparative magnetic study of the composites obtained by assisted microwave and traditional synthetic methods is reported. Display Omitted Highlights: → A rapid and efficient preparation of intercalated MnPS 3 composites by assisted microwave synthesis is described. → The exchange of potassium ions of the precursor by the macrocyclic Zn(II) complex is partial. → The composite obtained by assisted microwave synthesis retains the spontaneous magnetization, observed in the low temperature range of the magnetic susceptibility of the potassium precursor. → The materials obtained by the conventional method loose the spontaneous

  1. Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instability

    OpenAIRE

    Fukawatase, Yoshihiro; Toyoda, Masashi; Okamura, Kohji; Nakamura, Ken-ichi; Nakabayashi, Kazuhiko; Takada, Shuji; Yamazaki-Inoue, Mayu; Masuda, Akira; Nasu, Michiyo; Hata, Kenichiro; Hanaoka, Kazunori; Higuchi, Akon; Takubo, Kaiyo; Umezawa, Akihiro

    2014-01-01

    Ataxia telangiectasia is a neurodegenerative inherited disease with chromosomal instability and hypersensitivity to ionizing radiation. iPS cells lacking ATM (AT-iPS cells) exhibited hypersensitivity to X-ray irradiation, one of the characteristics of the disease. While parental ataxia telangiectasia cells exhibited significant chromosomal abnormalities, AT-iPS cells did not show any chromosomal instability in vitro for at least 80 passages (560 days). Whole exome analysis also showed a compa...

  2. N-hexanoyl-L-homoserine lactone-degrading Pseudomonas aeruginosa PsDAHP1 protects zebrafish against Vibrio parahaemolyticus infection.

    Science.gov (United States)

    Vinoj, Gopalakrishnan; Jayakumar, Rengarajan; Chen, Jiann-Chu; Withyachumnarnkul, Boonsirm; Shanthi, Sathappan; Vaseeharan, Baskaralingam

    2015-01-01

    Four strains of N-hexanoyl-L-homoserine lactone (AHL)-degrading Pseudomonas spp., named PsDAHP1, PsDAHP2, PsDAHP3, and PsDAHP4 were isolated and identified from the intestine of Fenneropenaeus indicus. PsDAHP1 showed the highest AHL-degrading activity among the four isolates. PsDAHP1 inhibited biofilm-forming exopolysaccharide and altered cell surface hydrophobicity of virulent green fluorescent protein (GFP)-tagged Vibrio parahaemolyticus DAHV2 (GFP-VpDAHV2). Oral administration of PsDAHP1 significantly reduced zebrafish mortality caused by GFP-VpDAHV2 challenge, and inhibited colonisation of GFP-VpDAHV2 in the gills and intestine of zebrafish as evidence by confocal laser scanning microscope and selective plating. Furthermore, zebrafish receiving PsDAHP1-containing feed had increased phagocytic cells of its leucocytes, increased serum activities of superoxide dismutase and lysozyme. The results suggest that Pseudomonas aeruginosa PsDAHP1 could protect zebrafish from V. parahaemolyticus infection by inhibiting biofilm formation and enhancing defence mechanisms of the fish. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Effectiveness of early adalimumab therapy in psoriatic arthritis patients from Reuma.pt - EARLY PsA.

    Science.gov (United States)

    Santos, Helena; Eusébio, Mónica; Borges, Joana; Gonçalves, Diana; Ávila-Ribeiro, Pedro; Faria, Daniela Santos; Lopes, Carina; Rovisco, João; Águeda, Ana; Nero, Patrícia; Valente, Paula; Cravo, Ana Rita; Santos, Maria José

    2017-01-01

    Objective To compare outcomes in psoriatic arthritis (PsA) patients initiating adalimumab (ADA), with short- and long-term disease duration and to evaluate the potential effect of concomitant conventional synthetic disease-modifying antirheumatic drugs (csDMARD) or glucocorticoids. Methods Analyses included adult PsA patients registered in the Rheumatic Diseases Portuguese Register (Reuma.pt) between June 2008-June 2016 who received ADA for ≥3 months. Psoriatic Arthritis Response Criteria (PsARC) response, tender and swollen joint count, inflammatory parameters, patient (PtGA) and physician global assessment (PhGA), Disease Activity Score-28 joints (DAS28), and Health Assessment Questionnaire Disability Index (HAQ-DI) were compared between patients with PsA) and those with ≥5 years of disease duration (late PsA). Time to achieving PsARC response was estimated using the Kaplan-Meier method. Results Of 135 PsA patients treated with ADA, 126 had information on disease duration (earlyPsA, n=41). PsARC response was achieved by 72.9% of the patients (88.0% early PsA vs 62.2% late PsA; P=0.022) after 3 months and by 85.4% after 24 months (100% early PsA vs 75.9% late PsA; P=0.044). Early PsA patients achieved significantly less painful joints (2.7 vs 6.7, p=0.006), lower mean C-reactive protein (0.5 mg/dL vs 1.3 mg/dL; P=0.011), and PhGA (18.3 vs 28.1; P=0.020) at 3 months. In the long term, early PsA patients also had fewer swollen joints (0.3 vs 1.7; P=0.030) and lower PhGA (6.3 vs 21.9; PPsA, respectively. Early PsA patients obtained PsARC response more rapidly than late PsA (3.8 and 7.4 months, respectively; P=0.008). Concomitant csDMARDs showed clinical benefit (2-year PsARC response, 88.3% vs 60.0%; P=0.044). Concomitant glucocorticoids had no effect on PsARC response over 2 years of follow-up. Persistence on ADA was similar in both groups. Conclusion Early PsA patients had a greater chance of improvement after ADA therapy and better functional outcome, and

  4. Duality in constrained location problems

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1987-01-01

    The dual of a facility location problem with general norms, distance constraints, and linear constraints is formulated.......The dual of a facility location problem with general norms, distance constraints, and linear constraints is formulated....

  5. ICE Online Detainee Locator System

    Data.gov (United States)

    Department of Homeland Security — The Online Detainee Locator datasets provide the location of a detainee who is currently in ICE custody, or who was release from ICE custody for any reason with the...

  6. OLBS: Offline location based services

    OpenAIRE

    Coelho, P; Ana Aguiar; João Correia Lopes

    2011-01-01

    Most existing location-based services rely on ubiquitous connectivity to deliver location-based contents to the users. However, connectivity is not available anywhere at anytime even in urban centres. Underground, indoors, remote areas, and foreign countries are examples situations where users commonly do not have guaranteed connectivity but could profit from location-based contents. In this work, we propose an open platform for publishing, distributing and maintaining location-based contents...

  7. LOCAT - A Data Retrieval Program.

    Science.gov (United States)

    1984-12-01

    onoitode of scified location - P C RADIUS - maximum distance between specified location and C file locationsC . ’ CONNON /LOCN/ LOCLAT, LOCLNG, RADIUS...rrr’, ,r:.- r -’ - r- rJ Z. . . , . -.-. - - - - - - -- , -• .. . . FILMED 8-85 DTIC .-. ... , ,- . . . . ...: .--. :,.:. ..-..-- ,-, .-..-...

  8. Beyond the Four Ps: A Theoretical Explication and Research Agenda for Social Marketing.

    Science.gov (United States)

    Sego, Trina

    Advocates of social marketing in the 1970s rarely went beyond discussion of the marketing 4Ps (product, place, promotion, and price) and their application to case studies. After two decades of research on social marketing, some misunderstanding of the approach persists, and a substantial theoretical base for social marketing has not been…

  9. Beam test results of a 16 ps timing system based on ultra-fast silicon detectors

    Energy Technology Data Exchange (ETDEWEB)

    Cartiglia, N., E-mail: cartiglia@to.infn.it [INFN, Torino (Italy); Staiano, A.; Sola, V. [INFN, Torino (Italy); Arcidiacono, R. [INFN, Torino (Italy); Università del Piemonte Orientale (Italy); Cirio, R.; Cenna, F.; Ferrero, M.; Monaco, V.; Mulargia, R.; Obertino, M.; Ravera, F.; Sacchi, R. [INFN, Torino (Italy); Università di Torino, Torino (Italy); Bellora, A.; Durando, S. [Università di Torino, Torino (Italy); Mandurrino, M. [Politecnico di Torino, Torino (Italy); Minafra, N. [University of Kansas, KS (United States); Fadeyev, V.; Freeman, P.; Galloway, Z.; Gkougkousis, E. [SCIPP, University of California Santa Cruz, CA 95064 (United States); and others

    2017-04-01

    In this paper we report on the timing resolution obtained in a beam test with pions of 180 GeV/c momentum at CERN for the first production of 45 µm thick Ultra-Fast Silicon Detectors (UFSD). UFSD are based on the Low-Gain Avalanche Detector (LGAD) design, employing n-on-p silicon sensors with internal charge multiplication due to the presence of a thin, low-resistivity diffusion layer below the junction. The UFSD used in this test had a pad area of 1.7 mm{sup 2}. The gain was measured to vary between 5 and 70 depending on the sensor bias voltage. The experimental setup included three UFSD and a fast trigger consisting of a quartz bar readout by a SiPM. The timing resolution was determined by doing Gaussian fits to the time-of-flight of the particles between one or more UFSD and the trigger counter. For a single UFSD the resolution was measured to be 34 ps for a bias voltage of 200 V, and 27 ps for a bias voltage of 230 V. For the combination of 3 UFSD the timing resolution was 20 ps for a bias voltage of 200 V, and 16 ps for a bias voltage of 230 V.

  10. Spin polarization in top pair production in association with two photons at NLO+PS

    CERN Document Server

    Luisoni, Gionata

    2018-01-01

    This talk focuses on the impact of top-quark spin polarization effects in Higgs boson production in association with a top-quark pair, where the Higgs boson decays to two photons. Predictions for the signal are compared with direct top-quark pair production in association with two photons at NLO+PS.

  11. Decoding the Vertical Phase Separation and Its Impact on C8-BTBT/PS Transistor Properties.

    Science.gov (United States)

    Pérez-Rodríguez, Ana; Temiño, Inés; Ocal, Carmen; Mas-Torrent, Marta; Barrena, Esther

    2018-02-28

    Disentangling the details of the vertical distribution of small semiconductor molecules blended with polystyrene (PS) and the contact properties are issues of fundamental value for designing strategies to optimize small-molecule:polymer blend organic transistors. These questions are addressed here for ultrathin blends of 2,7-dioctyl[1]benzothieno[3,2-b][1]benzothiophene (C8-BTBT) and PS processed by a solution-shearing technique using three different blend composition ratios. We show that friction force microscopy (FFM) allows the determination of the lateral and vertical distribution of the two materials at the nanoscale. Our results demonstrate a three-layer stratification of the blend: a film of C8-BTBT of few molecular layers with crystalline order sandwiched between a PS-rich layer at the bottom (a few nm thick) acting as a passivating dielectric layer and a PS-rich skin layer on the top (∼1 nm) conferring stability to the devices. Kelvin probe force microscopy (KPFM) measurements performed in operating organic field-effect transistors (OFETs) reveal that the devices are strongly contact-limited and suggest contact doping as a route for device optimization. By excluding the effect of the contacts, field-effect mobility values in the channel as high as 10 cm 2 V -1 s -1 are obtained. Our findings, obtained via a combination of FFM and KPFM, provide a satisfactory explanation of the different electrical performances of the OFETs as a function of the blend composition ratio and by doping the contacts.

  12. Proceedings of the workshop on deuteron beam acceleration in the KEK 12 GeV PS

    International Nuclear Information System (INIS)

    Mori, Yoshiharu

    1991-12-01

    The acceleration of atomic nucleus beam with the 12 GeV proton synchrotron in National Laboratory for High Energy Physics (KEK-PS) has been demanded by the experimenters of nuclear physics, and there was the move to concretely realize it at the beginning of 1980, but actually it was not materialized up to now due to various circumstances. The reason that makes the acceleration even in light nuclear beam like deuterons difficult is various, but one is that the acceleration method considered so far particularly in a booster main ring is very complicated. Recently as one of the various proposals made from the viewpoint of the future utilization of the KEK-PS, that of using nuclear beam and the experiment with the PS-collider have been discussed, and the method of accelerating nuclear beam in the PS was reexamined. As the result, together with the technical progress such as ring RF and linear accelerator augmentation, the method with high realization possibility became to be proposed. This proceedings is the report of the first workshop on deutron acceleration held on February 20, 1991, to prepare for the experiment using deuteron beam. (K.I.)

  13. PS-FW: A Hybrid Algorithm Based on Particle Swarm and Fireworks for Global Optimization

    Science.gov (United States)

    Chen, Shuangqing; Wei, Lixin; Guan, Bing

    2018-01-01

    Particle swarm optimization (PSO) and fireworks algorithm (FWA) are two recently developed optimization methods which have been applied in various areas due to their simplicity and efficiency. However, when being applied to high-dimensional optimization problems, PSO algorithm may be trapped in the local optima owing to the lack of powerful global exploration capability, and fireworks algorithm is difficult to converge in some cases because of its relatively low local exploitation efficiency for noncore fireworks. In this paper, a hybrid algorithm called PS-FW is presented, in which the modified operators of FWA are embedded into the solving process of PSO. In the iteration process, the abandonment and supplement mechanism is adopted to balance the exploration and exploitation ability of PS-FW, and the modified explosion operator and the novel mutation operator are proposed to speed up the global convergence and to avoid prematurity. To verify the performance of the proposed PS-FW algorithm, 22 high-dimensional benchmark functions have been employed, and it is compared with PSO, FWA, stdPSO, CPSO, CLPSO, FIPS, Frankenstein, and ALWPSO algorithms. Results show that the PS-FW algorithm is an efficient, robust, and fast converging optimization method for solving global optimization problems. PMID:29675036

  14. Masin, organism või psüühiline vangla? / Mikk Salu

    Index Scriptorium Estoniae

    Salu, Mikk, 1975-

    2008-01-01

    Juhtimisteoreetik Gareth Morgan õpetab oma raamatus "Organisatsiooni metafoorid" firmade toimimist ja juhtimist kaheksat eri tüüpi metafooride kaudu: organisatsioon kui masin, organism, aju, kultuur, poliitiline süsteem, psüühiline vangla, muutuste protsess, valitsemisvahend. Lisa: Praktiline õppevahend

  15. Transmissão psíquica entre as gerações

    Directory of Open Access Journals (Sweden)

    Olga B. Ruiz Correa

    2003-01-01

    Full Text Available O reconhecimento da alienação da subjetividade, comprometida numa transmissão psíquica geracional defeituosa, possibilita um novo olhar clínico sobre as patologias da modernidade. O vínculo mãe-bebê e o grupo familiar constituem o berço psíquico do sujeito, constituído por uma tecelagem grupal geracional que poderíamos denominar arquivos de família. Os processos de transmissão são sustentados por mecanismos de identificação junto a um interjogo de projeções-introjeções e incorporações, assim como por uma referência ao superego parental. Neste espaço psíquico intersubjetivo se processa a transmissão psíquica geracional, que precisa ser metabolizada e sofrer transformações. Na clínica do grupo familiar são considerados os traços traumáticos e feridas narcisistas que são transmitidos como restos do "negativo", sem modificação e de forma repetitiva, nos persos vínculos do espaço grupal-familiar, gerando, assim, persos sintomas e sofrimento intra e intersubjetivo.

  16. Au coated PS nanopillars as a highly ordered and reproducible SERS substrate

    Science.gov (United States)

    Kim, Yong-Tae; Schilling, Joerg; Schweizer, Stefan L.; Sauer, Guido; Wehrspohn, Ralf B.

    2017-07-01

    Noble metal nanostructures with nanometer gap size provide strong surface-enhanced Raman scattering (SERS) which can be used to detect trace amounts of chemical and biological molecules. Although several approaches were reported to obtain active SERS substrates, it still remains a challenge to fabricate SERS substrates with high sensitivity and reproducibility using low-cost techniques. In this article, we report on the fabrication of Au sputtered PS nanopillars based on a template synthetic method as highly ordered and reproducible SERS substrates. The SERS substrates are fabricated by anodic aluminum oxide (AAO) template-assisted infiltration of polystyrene (PS) resulting in hemispherical structures, and a following Au sputtering process. The optimum gap size between adjacent PS nanopillars and thickness of the Au layers for high SERS sensitivity are investigated. Using the Au sputtered PS nanopillars as an active SERS substrate, the Raman signal of 4-methylbenzenethiol (4-MBT) with a concentration down to 10-9 M is identified with good signal reproducibility, showing great potential as promising tool for SERS-based detection.

  17. Septum magnet for ejection from the PS to the E-Hall

    CERN Multimedia

    CERN PhotoLab

    1977-01-01

    Pulsed septum magnet for ejection from PS straight sections 61/62 to the East-Hall. This septum magnet, for ss 61, had only 1 turn, for minimum thickness. It was followed by another septum in ss 62, with 2 turns, as there the ejected beam was already farther away from the circulating beam. Both septa were water-cooled.

  18. Free volume changes in mechanically milled PS and PC studied by positron annihilation lifetime spectroscopy (PALS)

    NARCIS (Netherlands)

    Günther-Schade, K.; Castricum, H.L.; Ziegler, H.J.; Bakker, H.; Faupel, F.

    2004-01-01

    The effect of mechanical milling on free volume was studied by means of positron annihilation lifetime spectroscopy (PALS) in polystyrene (PS) as a typical brittle polymer and in polycarbonate (PC) as a tough representative. Long-time milling increases the free volume, while a decrease is observed

  19. Genomic differentiation among two strains of the PS1 clade isolated from geographically separated marine habitats

    KAUST Repository

    Jimenez Infante, Francy M.

    2014-05-22

    Using dilution-to-extinction cultivation, we isolated a strain affiliated with the PS1 clade from surface waters of the Red Sea. Strain RS24 represents the second isolate of this group of marine Alphaproteobacteria after IMCC14465 that was isolated from the East (Japan) Sea. The PS1 clade is a sister group to the OCS116 clade, together forming a putatively novel order closely related to Rhizobiales. While most genomic features and most of the genetic content are conserved between RS24 and IMCC14465, their average nucleotide identity (ANI) is < 81%, suggesting two distinct species of the PS1 clade. Next to encoding two different variants of proteorhodopsin genes, they also harbor several unique genomic islands that contain genes related to degradation of aromatic compounds in IMCC14465 and in polymer degradation in RS24, possibly reflecting the physicochemical differences in the environment they were isolated from. No clear differences in abundance of the genomic content of either strain could be found in fragment recruitment analyses using different metagenomic datasets, in which both genomes were detectable albeit as minor part of the communities. The comparative genomic analysis of both isolates of the PS1 clade and the fragment recruitment analysis provide first insights into the ecology of this group. © 2014 Federation of European Microbiological Societies.

  20. The PS 200 catching trap: A new tool for ultra-low energy antiproton physics

    International Nuclear Information System (INIS)

    Holzscheiter, M.H.; Dyer, P.L.; King, N.S.P.; Lizon, D.C.; Morgan, G.L.; Schauer, M.M.; Schecker, J.A.; Hoibraten, S.; Lewis, R.A.; Otto, T.

    1994-01-01

    Approximately one million antiprotons have been trapped and electron cooled in the PS200 catching trap from a single fast extracted pulse from LEAR. The system is described in detail, different extraction schemes are discussed, and possible applications of this instrument to ultra-low energy atomic and nuclear physics with antiprotons are mentioned

  1. Orbit, optics and chromaticity correction for PS2 negative momentum compaction lattices

    Energy Technology Data Exchange (ETDEWEB)

    Papaphilippou,Y.; Barranco, J.; Bartmann, W.; Benedikt, M.; Carli, C.; de Maria, R.; Peggs, S.; Trbojevic, D.

    2009-05-04

    The effect of magnet misalignments in the beam orbit and linear optics functions are reviewed and correction schemes are applied to the negative momentum compaction lattice of PS2. Chromaticity correction schemes are also proposed and tested with respect to off-momentum optics properties. The impact of the correction schemes in the dynamic aperture of the lattice is finally evaluated.

  2. A microchannel plate X-ray multiplier with rising-time less than 170 ps

    International Nuclear Information System (INIS)

    Zhao Shicheng; Ouyang Bin

    1987-01-01

    The time reponse of a microchannel plate X-ray multiplier has been improved considerably by using a coupling construction of coaxial tapers. The experimental calibration results with laser plasma X-ray source show that the rising-time of the multiplier is less than 170 ps

  3. Detectors and Concepts for sub-100 ps timing with gaseous detectors

    CERN Document Server

    Gonzalez-Diaz, D.

    2017-01-01

    We give a short compendium of the main ongoing detectors and concepts capable of performing accurate sub-100 ps timing at high particle fluxes and on large areas, through technologies based on gaseous media. We briefly discuss the state-of-the-art, technological limitations and prospects, and a new bizarre idea.

  4. Preparation of the beam for PS-MTE at the PSB

    CERN Document Server

    Chanel, M; CERN. Geneva. BE Department

    2009-01-01

    The Multi-Turn Extraction(MTE)1 at the PS requires, from the PSB, a beam(up to 6.5 1012 protons/ring) with a large horizontal emittance to better produce the five beamlets and a vertical emittance as small as possible. The ways to produce this beam and adjust the parameters are described in this note.

  5. 1170-MW(t) HTGR-PS/C plant application study report: heavy oil recovery application

    International Nuclear Information System (INIS)

    Rao, R.; McMain, A.T. Jr.

    1981-05-01

    This report describes the application of a high-temperature gas-cooled reactor (HTGR) which operates in a process steam/cogeneration (PS/C) mode in supplying steam for enhanced recovery of heavy oil and in exporting electricity. The technical and economic merits of an 1170-MW(t) HTGR-PS/C are compared with those of coal-fired plants and (product) oil-fired boilers for this application. The utility requirements for enhanced oil recovery were calculated by establishing a typical pattern of injection wells and production wells for an oil field similar to that of Kern County, California. The safety and licensing issues of the nuclear plant were reviewed, and a comparative assessment of the alternative energy sources was performed. Technically and economically, the HTGR-PS/C plant has attractive merits. The major offsetting factors would be a large-scale development of a heavy oil field by a potential user for the deployment of a 1170-MW(t) HTGR-PS/C; plant and the likelihood of available prime heavy oil fields for the mid-1990 operation

  6. 75 FR 66734 - Proposed Voluntary Product Standard PS 2-10, Structural Plywood

    Science.gov (United States)

    2010-10-29

    ... acceptability of wood-based structural-use panels for construction sheathing and single-floor applications. It... acceptability of wood-based structural-use panels for construction sheathing and single- floor application, and... to Voluntary Product Standard (PS) 2-04, Performance Standard for Wood-Based Structural-Use Panels...

  7. Morphology and properties of SEBS block copolymer compatibilized PS/HDPE blends

    Czech Academy of Sciences Publication Activity Database

    Rek, V.; Vranješ, N.; Šlouf, Miroslav; Fortelný, Ivan; Jelčic, Ž.

    2008-01-01

    Roč. 40, č. 3 (2008), s. 237-251 ISSN 0095-2443 Grant - others:Ministry of Science, Education and Sport (HR) 0125059 Institutional research plan: CEZ:AV0Z40500505 Keywords : aPS/HDPE/SEBS blends * morphology * processing * rheological Subject RIV: CD - Macromolecular Chemistry Impact factor: 0.658, year: 2008

  8. 7YSZ coating prepared by PS-PVD based on heterogeneous nucleation

    Directory of Open Access Journals (Sweden)

    Ziqian DENG

    2018-04-01

    Full Text Available Plasma spray-physical vapor deposition (PS-PVD as a novel coating process based on low-pressure plasma spray (LPPS has been significantly used for thermal barrier coatings (TBCs. A coating can be deposited from liquid splats, nano-sized clusters, and the vapor phase forming different structured coatings, which shows obvious advantages in contrast to conventional technologies like atmospheric plasma spray (APS and electron beam-physical vapor deposition (EB-PVD. In addition, it can be used to produce thin, dense, and porous ceramic coatings for special applications because of its special characteristics, such as high power, very low pressure, etc. These provide new opportunities to obtain different advanced microstructures, thus to meet the growing requirements of modern functional coatings. In this work, focusing on exploiting the potential of gas-phase deposition from PS-PVD, a series of 7YSZ coating experiments with various process conditions was performed in order to better understand the deposition process in PS-PVD, where coatings were deposited on different substrates including graphite and zirconia. Meanwhile, various substrate temperatures were investigated for the same substrate. As a result, a deposition mechanism of heterogeneous nucleation has been presented showing that surface energy is an important influencing factor for coating structures. Besides, undercooling of the interface between substrate and vapor phase plays an important role in coating structures. Keywords: 7YSZ, Deposition mechanism, Heterogeneous nucleation, PS-PVD, TBC

  9. Physics at the AD/PS/SPS - PLEASE NOTE CHANGE OF ROOM!(2/4)

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    Lecture 2: QCD and hadron physics: COMPASS, NA61, DIRAC The lecture will discuss the research done at the COMPASS, SHINE and DIRAC experiments at the SPS and PS. COMPASS studies nucleon structure and hadron spectroscopy, SHINE searches for the critical point and onset of deconfinement in heavy ion collisions while DIRAC studies the pi-pi scattering length in pionic atoms.

  10. Mõnede eesti sõnajärjemallide psühholingvistilisest reaalsusest / Annekatrin Kaivapalu

    Index Scriptorium Estoniae

    Kaivapalu, Annekatrin, 1963-

    2010-01-01

    Eesti vahekeele korpuse põhjal selgitatakse, milliseid sõnajärjemalle peetakse loomulikeks ja milliseid mitte, et tulemuste põhjal kirjeldada mõnede eesti keele sõnajärjemallide psühholingvistilist reaalsust ning määratleda sõnajärjevigade prioriteetsus

  11. Spin polarization in top pair production in association with two photons at NLO+PS

    CERN Document Server

    Luisoni, Gionata

    2017-01-01

    This talk focuses on the impact of top-quark spin polarization effects in Higgs boson production in association with a top-quark pair, where the Higgs boson decays to two photons. Predictions for the signal are compared with direct top-quark pair production in association with two photons at NLO+PS.

  12. Genomic differentiation among two strains of the PS1 clade isolated from geographically separated marine habitats

    KAUST Repository

    Jimenez Infante, Francy M.; Ngugi, David; Alam, Intikhab; Rashid, Mamoon; Ba Alawi, Wail; Kamau, Allan; Bajic, Vladimir B.; Stingl, Ulrich

    2014-01-01

    Using dilution-to-extinction cultivation, we isolated a strain affiliated with the PS1 clade from surface waters of the Red Sea. Strain RS24 represents the second isolate of this group of marine Alphaproteobacteria after IMCC14465 that was isolated

  13. The quinternary thiophosphate Cs0.5Ag0.5Nb2PS10

    Directory of Open Access Journals (Sweden)

    Sojeong Park

    2010-07-01

    Full Text Available The quinternary thiophosphate Cs0.5Ag0.5Nb2PS10, cesium silver tris(disulfido[tetrathiophosphato(V]diniobate(IV, has been prepared from the elements using a CsCl flux. The crystal structure is made up of ∞1[Nb2PS10] chains expanding along [010]. These chains are built up from bicapped trigonal-prismatic [Nb2S12] units and tetrahedral [PS4] groups and are linked through a linear S—Ag—S bridge, forming a two-dimensional layer. These layers then stack on top of each other, completing the three-dimensional structure with an undulating van der Waals gap. The disordered Cs+ ions reside on sites with half-occupation in the voids of this arrangement. Short [2.8843 (5 Å] and long [3.7316 (4 Å] Nb—Nb distances alternate along the chains, and anionic S22− and S2− species are observed. The charge balance of the compound can be represented by the formula [Cs+]0.5[Ag+]0.5[Nb4+]2[PS43−][S22−]3.

  14. Testing the YerPhI Transimpedance Preamplifier with PPC by the T11 PS Beam

    CERN Document Server

    Parlakian, L K; CERN. Geneva; Martmianov, A N

    1997-01-01

    We report on the test of the preamplifier, described in [1], by the 3 GeV/c positive particle T11 beam of PS/CERN. We have measured the amplitude and time of flight spectrum, the time resolution and detection efficiency. The preamplifier has shown a stable work and hardness to the chamber discharge. The test results are presented.

  15. Radiation Effects on PP/PS Blends as a Model of Protection Effects by Aromatics

    International Nuclear Information System (INIS)

    Gluszewski, W.

    2006-01-01

    Polypropylene (PP) is the most popular polymer for the application in construction of medical devices, due to the hardness and temperature resistance. Unfortunately, the virgin PP is of low resistance towards ionizing radiation, already to sterilization doses and cannot be applied without additives. Another option is a blend with a second polymer, especially aromatic, and therefore polystyrene (PS) was applied. The classic case of protection in the aliphatic/aromatic system (benzene/cyclohexane in liquid or solid state) shows that the surface area and structure of the interphase is crucial for the effectiveness of energy transfer. Our blends of PP (virgin, F401 from Orlen-Olefins) with PS were prepared in a variety of ways, from mechanical blending, to radiation induced grafting. Two linac accelerators (10 MeV, 6-9 kW) were applied, with different shapes of electron beam, formed according to particular methods used for the investigation of effects; doses were 10-600 kGy. As in the classic case, the protection effect was quantisized from the curve of the effect vs 0-100% PP, 100-0 % PS. Main recognition of the protection effect has been done by the diffused reflection spectroscopy (DRS) developed in our Laboratory for the application to irradiated polymers. The dependence of intensity of bands in the DRS spectrum, attributed to keton groups, which are final products of oxidation, shows clearly the protection effect of PP, executed by PS. The second method of observation of radiation effects is gas chromatography (GC), applied for irradiation products analysis. The maximum sensitivity has been achieved using the instrument type GC 2014 by Shimadzu, with thermal conductivity detector, column packed with molecular sieves 5A. Radiation induced formation of gaseous produced at ambient and lower temperatures is unique in the field of chemistry of polymers. There is no form of energy, except ionizing radiation, to cause chemical reactions to produce a wide spectrum of low

  16. ANATOMICAL PROPERTIES OF Shorea mujongensis P.S. Ashton, A CRITICALLY ENDANGERED SPECIES OF DIPTEROCARPS FROM KALIMANTAN

    Directory of Open Access Journals (Sweden)

    Listya Mustika Dewi

    2011-12-01

    Full Text Available Wood anatomy of Shorea mujongensis P.S. Ashton was investigated in order to ensure this species belongs to yellow meranti group. Such study is very important since this species is already listed in the red list of IUCN and classified as critically endangered species. The microscopic slides were prepared according to the Johansen's method, while the anatomical features observed according to the IAWA  List. The results show that S. mujongensis wood exhibit brown heartwood, light brown sapwood, rough texture, straight grain sometimes interlocked and somewhat rough. The main microscopic characters are growth rings indistinct; vessel diffuse, mostly solitary, rounded to oval; simple perforation plate and alternate intervessel pits; parenchyma scanty paratracheal to thin vasicentric; axial intercellular canals in long tangential line, radial intercellular canal and vasicentric tracheids present; rays uniseriate and multiseriate, prismatic crystal in procumbent cells; fiber length 1,294 µm, diameter 26 µm and wall thickness 4µm. Macroscopic and microscopic observation of S. mujongensis wood confirms the species belongs to yellow meranti group. The assesment on fiber dimensions and derived values of the wood fibers classified the wood into class quality II. It indicates that this species is moderately favorable as raw material for pulp and paper manufacture.

  17. Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice.

    Science.gov (United States)

    Leroy, Karelle; Ando, Kunie; Laporte, Vincent; Dedecker, Robert; Suain, Valérie; Authelet, Michèle; Héraud, Céline; Pierrot, Nathalie; Yilmaz, Zehra; Octave, Jean-Noël; Brion, Jean-Pierre

    2012-12-01

    Lack of tau expression has been reported to protect against excitotoxicity and to prevent memory deficits in mice expressing mutant amyloid precursor protein (APP) identified in familial Alzheimer disease. In APP mice, mutant presenilin 1 (PS1) enhances generation of Aβ42 and inhibits cell survival pathways. It is unknown whether the deficient phenotype induced by concomitant expression of mutant PS1 is rescued by absence of tau. In this study, we have analyzed the effect of tau deletion in mice expressing mutant APP and PS1. Although APP/PS1/tau(+/+) mice had a reduced survival, developed spatial memory deficits at 6 months and motor impairments at 12 months, these deficits were rescued in APP/PS1/tau(-/-) mice. Neuronal loss and synaptic loss in APP/PS1/tau(+/+) mice were rescued in the APP/PS1/tau(-/-) mice. The amyloid plaque burden was decreased by roughly 50% in the cortex and the spinal cord of the APP/PS1/tau(-/-) mice. The levels of soluble and insoluble Aβ40 and Aβ42, and the Aβ42/Aβ40 ratio were reduced in APP/PS1/tau(-/-) mice. Levels of phosphorylated APP, of β-C-terminal fragments (CTFs), and of β-secretase 1 (BACE1) were also reduced, suggesting that β-secretase cleavage of APP was reduced in APP/PS1/tau(-/-) mice. Our results indicate that tau deletion had a protective effect against amyloid induced toxicity even in the presence of mutant PS1 and reduced the production of Aβ. Copyright © 2012 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  18. NaPdPS{sub 4} and RbPdPS{sub 4}: systems with infinite straight ((1)/({infinity}))[PdPS{sub 4}]{sup -} chains soluble in polar solvents and the structure of cubic RbPdPS{sub 4}{l_brace}Rb{sub 0.33}P{sub 0.4}S{sub 2.23}O{sub x}{r_brace}

    Energy Technology Data Exchange (ETDEWEB)

    Coste, Servane; Hanko, Jason; Bujoli-Doeuff, Martine; Louarn, Guy; Evain, Michel; Brec, Raymond; Alonso, Bruno; Jobic, S; Kanatzidis, Mercouri G

    2003-11-01

    The synthesis, crystal structures, chemical and spectroscopic properties of NaPdPS{sub 4}, RbPdPS{sub 4}, and RbPdPS{sub 4}{l_brace}Rb{sub 0.33}P{sub 0.4}S{sub 2.23}O{sub x}{r_brace} are described. NaPdPS{sub 4}, RbPdPS{sub 4}, are isostructural and crystallize in the tetragonal system I4/mcm with cell parameters a=7.3074(8) A, c=12.2308(14) A and a=8.2954(3) A, c=12.2284(4) A respectively. RbPdPS{sub 4}{l_brace}Rb{sub 0.33}P{sub 0.4}S{sub 2.23}O{sub x}{r_brace} is cubic, space group Pm-3n and a=12.0042(2) A. All compounds contain the same ((1)/({infinity}))[PdPS{sub 4}]{sup -} chains made of alternating square planar Pd{sup 2+} cations and tetrahedral [PS{sub 4}]{sup 3-} anions. RbPdPS{sub 4}{l_brace}Rb{sub 0.33}P{sub 0.4}S{sub 2.23}O{sub x}{r_brace} contains co-crystallized highly disordered molecular species encapsulated within [Rb{sub 8}] cubic cavities. Spectroscopic solid state {sup 31}P NMR, infrared and Raman data as well as elemental analysis suggest that these species could be S{sub n}{sup 2-} (n=3 or 4) anions and possibly cationic [P{sub 4}S{sub 6}O]{sup 6+} fragments. NaPdPS{sub 4} and RbPdPS{sub 4} exhibit exfoliative dissolution in polar solvents giving rise to solutions that show signs of complex fluid behavior.

  19. Location theory a unified approach

    CERN Document Server

    Nickel, Stefan

    2006-01-01

    Although modern location theory is now more than 90 years old, the focus of researchers in this area has been mainly problem oriented. However, a common theory, which keeps the essential characteristics of classical location models, is still missing.This monograph addresses this issue. A flexible location problem called the Ordered Median Problem (OMP) is introduced. For all three main subareas of location theory (continuous, network and discrete location) structural properties of the OMP are presented and solution approaches provided. Numerous illustrations and examples help the reader to bec

  20. Analisis de PPcPs (pharmaceutical and personal care products en aguas residuales y suelos

    Directory of Open Access Journals (Sweden)

    Johana Andrea Velásquez Arias

    2016-12-01

    Full Text Available Los productos farmacéuticos y de higiene personal (PPcPs son conocidos como contaminantes emergentes,  ampliamente usados  por la sociedad  moderna. Las estaciones depuradoras de aguas residuales (EDAR, mitigan la presencia de estos contaminantes emergentes en los efluentes que vierten al medio ambiente. La eficiencia de eliminación de las EDAR, varían en base a la precisión en la detección y en las técnicas utilizadas. Este estudio revisó literatura para estudios que informaron sobre la presencia de PPcPs en aguas, estaciones depuradoras de aguas residuales y suelos, las técnicas biológicas degradadoras utilizadas y la frecuencia de evaluaciones ecotoxicológicas. Tras la búsqueda bibliográfica, se obtuvieron 119 artículos relacionados con la presencia PPcPs en suelos y aguas, de los cuales el 7% son revisiones que incluyen datos de degradación por estrategias de biorremediación, técnicas físico-químicas, acumulación de PPcPs en aguas y plantas y efectos en los organismos, el 40% se centran en aguas superficiales y estaciones depuradoras de aguas residuales, el 28% en suelos irrigados con aguas residuales recuperadas o abonados con lodos de depuradoras y por último, solamente el 22% realizaron ensayos ecotoxicológicos en aguas y el 3% en suelos. A partir de estos resultados se puede concluir que, es necesario hacer énfasis en la realización de estudios sobre comunidades bacterianas con capacidad degradadora de PPcPS, así como la incorporación de ensayos ecotoxicológicos que confirmen la optimización del proceso.

  1. Synthesis and Characterization of the Rubidium Thiophosphate Rb 6 (PS 5 )(P 2 S 10 ) and the Rubidium Silver Thiophosphates Rb 2 AgPS 4 , RbAg 5 (PS 4 ) 2 and Rb 3 Ag 9 (PS 4 ) 4

    KAUST Repository

    Alahmary, Fatimah S.

    2016-02-18

    The metal thiophosphates Rb2AgPS4 (2), RbAg5(PS4)2 (3), and Rb3Ag9(PS4)4 (4) were synthesized by stoichiometric reactions, whereas Rb6(PS5)(P2S10) (1) was prepared with excess amount of sulfur. The compounds crystallize as follows: 1 monoclinic, P21/c (no. 14), a = 17.0123(7) Å, b = 6.9102(2) Å, c = 23.179(1) Å, β = 94.399(4)°; 2 triclinic, P ¯ (no. 2), a = 6.600(1) Å, b = 6.856(1) Å, c = 10.943(3) Å, α = 95.150(2)°, β = 107.338(2)°, γ = 111.383(2)°; 3 orthorhombic, Pbca (no. 61), a = 12.607(1) Å, b = 12.612(1) Å, c = 17.759(2) Å; 4 orthorhombic, Pbcm (no. 57), a = 6.3481(2) Å, b = 12.5782(4) Å, c = 35.975(1) Å. The crystal structures contain discrete units, chains, and 3D polyanionic frameworks composed of PS4 tetrahedral units arranged and connected in different manner. Compounds 1-3 melt congruently, whereas incongruent melting behavior was observed for compound 4. 1-4 are semiconductors with bandgaps between 2.3 and 2.6 eV and thermally stable up to 450 °C in an inert atmosphere. Copyright © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells.

    Science.gov (United States)

    Kannappan, Ramaswamy; Mattapally, Saidulu; Wagle, Pooja A; Zhang, Jianyi

    2018-05-18

    The role of p53 transactivation domain (p53-TAD), a multifunctional and dynamic domain, on DNA repair and retaining DNA integrity in human iPS cells has never been studied. p53-TAD was knocked out in iPS cells using CRISPR/Cas9 and was confirmed by DNA sequencing. p53-TAD KO cells were characterized by: accelerated proliferation, decreased population doubling time, and unaltered Bcl2, BBC3, IGF1R, Bax and altered Mdm2, p21, and PIDD transcripts expression. In p53-TAD KO cells p53 regulated DNA repair proteins XPA, DNA polH and DDB2 expression were found to be reduced compared to p53-WT cells. Exposure to low dose of doxorubicin (Doxo) induced similar DNA damage and DNA damage response (DDR) measured by RAD50 and MRE11 expression, Checkpoint kinase 2 activation and γH2A.X recruitment at DNA strand breaks in both the cell groups indicating silencing p53-TAD do not affect DDR mechanism upstream of p53. Following removal of Doxo p53-WT hiPS cells underwent DNA repair, corrected their damaged DNA and restored DNA integrity. Conversely, p53-TAD KO hiPS cells did not undergo complete DNA repair and failed to restore DNA integrity. More importantly continuous culture of p53-TAD KO hiPS cells underwent G2/M cell cycle arrest and expressed cellular senescent marker p16 INK4a . Our data clearly shows that silencing transactivation domain of p53 did not affect DDR but affected the DNA repair process implying the crucial role of p53 transactivation domain in maintaining DNA integrity. Therefore, activating p53-TAD domain using small molecules may promote DNA repair and integrity of cells and prevent senescence.

  3. Location of Urban Logistic Terminals as Hub Location Problem

    Directory of Open Access Journals (Sweden)

    Jasmina Pašagić Škrinjar

    2012-09-01

    Full Text Available In this paper the problems of locating urban logistic terminals are studied as hub location problems that due to a large number of potential nodes in big cities belong to hard non-polynomial problems, the so-called NP-problems. The hub location problems have found wide application in physical planning of transport and telecommunication systems, especially systems of fast delivery, networks of logistic and distribution centres and cargo traffic terminals of the big cities, etc. The paper defines single and multiple allocations and studies the numerical examples. The capacitated single allocation hub location problems have been studied, with the provision of a mathematical model of selecting the location for the hubs on the network. The paper also presents the differences in the possibilities of implementing the exact and heuristic methods to solve the actual location problems of big dimensions i.e. hub problems of the big cities.

  4. Location, Location, Location: Does Place Provide the Opportunity for Differentiation for Universities?

    Science.gov (United States)

    Winter, Emma; Thompson-Whiteside, Helen

    2017-01-01

    The fiercely competitive HE market has led HEIs to invest significant resources in building a distinct identity. An HEI's location forms an inherent part of its identity and the uniqueness of location offers an opportunity to differentiate. However there has been limited examination of how location is used by HEIs and little consideration of how…

  5. Location Systems An Introduction to the Technology Behind Location Awareness

    CERN Document Server

    LaMarca, Anthony

    2008-01-01

    Advances in electronic location technology and the coming of age of mobile computing have opened the door for location-aware applications to permeate all aspects of everyday life. Location is at the core of a large number of high-value applications ranging from the life-and-death context of emergency response to serendipitous social meet-ups. For example, the market for GPS products and services alone is expected to grow to US200 billion by 2015. Unfortunately, there is no single location technology that is good for every situation and exhibits high accuracy, low cost, and universal coverage.

  6. Differential expression of GSK3β and pS9GSK3β in normal human tissues: can pS9GSK3β be an epithelial marker?

    Science.gov (United States)

    Lee, Hojung; Ro, Jae Y

    2015-01-01

    Glycogen synthase kinase 3β (GSK3β) and phosphorylated GSK3β at Ser9 (pS9GSK3β) are crucial in cellular proliferation and metabolism. GSK3β and pS9GSK3β are deregulated in many diseases including tumors. Data on altered expression of GSK3β and pS9GSK3β are mainly limited to tumor tissues, thus the expression of GSK3β and pS9GSK3β in normal human tissue has been largely unknown. Thus, we examined the immunohistochemical localization of GSK3β and pS9GSK3β in human fetal and adult tissues, and also compared the expression pattern of GSK3β and pS9GSK3β with that of the CK7 and CK20. We found GSK3β expression in neurons of brain, myenteric plexus in gastrointestinal tract, squamous epithelium of skin, and mammary gland. The expression of pS9GSK3β was restricted to the epithelial cells of breast and pancreaticobiliary duct, distal nephron of kidney, gastrointestinal tract, fallopian tube, epididymis, secretory cell of prostatic gland, and umbrella cell of urinary tract. The staining pattern of pS9GSK3β and CK7 was overlapped in most organs except for gastrointestinal tract where CK7 was negative and CK20 was positive. Our results show that the expression of GSK3β may be associated with differentiation of ectodermal derived tissues and pS9GSK3β with that of epithelial cells of endodermal derived tissues in human. In addition, the expression of pS9GSK3β in the selective epithelial cells may indicate its association with secretory or barrier function of specific cells and may serve as another immunohistochemical marker for epithelial cells.

  7. Effect of angiotensin II on proliferation and differentiation of mouse induced pluripotent stem cells into mesodermal progenitor cells

    Energy Technology Data Exchange (ETDEWEB)

    Ishizuka, Toshiaki, E-mail: tishizu@ndmc.ac.jp [Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama 359-8513 (Japan); Goshima, Hazuki; Ozawa, Ayako; Watanabe, Yasuhiro [Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama 359-8513 (Japan)

    2012-03-30

    Highlights: Black-Right-Pointing-Pointer Treatment with angiotensin II enhanced LIF-induced DNA synthesis of mouse iPS cells. Black-Right-Pointing-Pointer Angiotensin II may enhance the DNA synthesis via induction of superoxide. Black-Right-Pointing-Pointer Treatment with angiotensin II significantly increased JAK/STAT3 phosphorylation. Black-Right-Pointing-Pointer Angiotensin II enhanced differentiation into mesodermal progenitor cells. Black-Right-Pointing-Pointer Angiotensin II may enhance the differentiation via activation of p38 MAPK. -- Abstract: Previous studies suggest that angiotensin receptor stimulation may enhance not only proliferation but also differentiation of undifferentiated stem/progenitor cells. Therefore, in the present study, we determined the involvement of the angiotensin receptor in the proliferation and differentiation of mouse induced pluripotent stem (iPS) cells. Stimulation with angiotensin II (Ang II) significantly increased DNA synthesis in mouse iPS cells cultured in a medium with leukemia inhibitory factor (LIF). Pretreatment of the cells with either candesartan (a selective Ang II type 1 receptor [AT{sub 1}R] antagonist) or Tempol (a cell-permeable superoxide scavenger) significantly inhibited Ang II-induced DNA synthesis. Treatment with Ang II significantly increased JAK/STAT3 phosphorylation. Pretreatment with candesartan significantly inhibited Ang II- induced JAK/STAT3 phosphorylation. In contrast, induction of mouse iPS cell differentiation into Flk-1-positive mesodermal progenitor cells was performed in type IV collagen (Col IV)- coated dishes in a differentiation medium without LIF. When Col IV-exposed iPS cells were treated with Ang II for 5 days, the expression of Flk-1 was significantly increased compared with that in the cells treated with the vehicle alone. Pretreatment of the cells with both candesartan and SB203580 (a p38 MAPK inhibitor) significantly inhibited the Ang II- induced increase in Flk-1 expression

  8. Effect of angiotensin II on proliferation and differentiation of mouse induced pluripotent stem cells into mesodermal progenitor cells

    International Nuclear Information System (INIS)

    Ishizuka, Toshiaki; Goshima, Hazuki; Ozawa, Ayako; Watanabe, Yasuhiro

    2012-01-01

    Highlights: ► Treatment with angiotensin II enhanced LIF-induced DNA synthesis of mouse iPS cells. ► Angiotensin II may enhance the DNA synthesis via induction of superoxide. ► Treatment with angiotensin II significantly increased JAK/STAT3 phosphorylation. ► Angiotensin II enhanced differentiation into mesodermal progenitor cells. ► Angiotensin II may enhance the differentiation via activation of p38 MAPK. -- Abstract: Previous studies suggest that angiotensin receptor stimulation may enhance not only proliferation but also differentiation of undifferentiated stem/progenitor cells. Therefore, in the present study, we determined the involvement of the angiotensin receptor in the proliferation and differentiation of mouse induced pluripotent stem (iPS) cells. Stimulation with angiotensin II (Ang II) significantly increased DNA synthesis in mouse iPS cells cultured in a medium with leukemia inhibitory factor (LIF). Pretreatment of the cells with either candesartan (a selective Ang II type 1 receptor [AT 1 R] antagonist) or Tempol (a cell-permeable superoxide scavenger) significantly inhibited Ang II-induced DNA synthesis. Treatment with Ang II significantly increased JAK/STAT3 phosphorylation. Pretreatment with candesartan significantly inhibited Ang II- induced JAK/STAT3 phosphorylation. In contrast, induction of mouse iPS cell differentiation into Flk-1-positive mesodermal progenitor cells was performed in type IV collagen (Col IV)- coated dishes in a differentiation medium without LIF. When Col IV-exposed iPS cells were treated with Ang II for 5 days, the expression of Flk-1 was significantly increased compared with that in the cells treated with the vehicle alone. Pretreatment of the cells with both candesartan and SB203580 (a p38 MAPK inhibitor) significantly inhibited the Ang II- induced increase in Flk-1 expression. Treatment with Ang II enhanced the phosphorylation of p38 MAPK in Col IV- exposed iPS cells. These results suggest that the stimulation

  9. Mõõtmise probleem 18. sajandi psühholoogias / Konstantin Ramul ; tõlk. Kenn Konstabel

    Index Scriptorium Estoniae

    Ramul, Konstantin, 1879-1975

    2004-01-01

    Mentaalsete mõõtmiste tähtsusest 18. sajandil teadusliku psühholoogia arengule 19. sajandil. 18. sajandi erinevate autorite arvamustest psühholoogiliste mõõtmiste võimalustest ja meetoditest. Varem ilmunud: American Psychologist, 1960, nr. 15, lk. 256-265

  10. Mõned varased mõõtmised ja hindamised psühholoogias / Konstantin Ramul ; tõlk. Kenn Konstabel

    Index Scriptorium Estoniae

    Ramul, Konstantin, 1879-1975

    2004-01-01

    Varajaste psühholoogiliste mõõtmiste ja hinnangute kirjeldusi, mis on tehtud ajaloo jooksul mittepsühholoogide poolt ja mida ei tehtud psühholoogilise uurimistöö huvides. Varem ilmunud: American Psychologist, 1963, nr. 18 (10), lk. 653-659

  11. Nearly penalty-free, less than 4 ps supercontinuum Gbit/s pulse generation over 1535-1560 nm

    Science.gov (United States)

    Morioka, T.; Kawanishi, S.; Mori, K.; Saruwatari, M.

    1994-05-01

    Nearly penalty-free less than 4ps supercontinuum WDM pulses are generated at 6.3 Gbit/s over 1535-1560 nm for the first time using a 200 nm superbroadened supercontinuum in an optical fibre pumped by 1.7 W, 3.3 ps, 1542 nm short pulses from an Er(3+)-doped fibre ring laser.

  12. MYC cis-Elements in PsMPT Promoter Is Involved in Chilling Response of Paeonia suffruticosa.

    Directory of Open Access Journals (Sweden)

    Yuxi Zhang

    Full Text Available The MPT transports Pi to synthesize ATP. PsMPT, a chilling-induced gene, was previously reported to promote energy metabolism during bud dormancy release in tree peony. In this study, the regulatory elements of PsMPT promoter involved in chilling response were further analyzed. The PsMPT transcript was detected in different tree peony tissues and was highly expressed in the flower organs, including petal, stigma and stamen. An 1174 bp of the PsMPT promoter was isolated by TAIL-PCR, and the PsMPT promoter::GUS transgenic Arabidopsis was generated and analyzed. GUS staining and qPCR showed that the promoter was active in mainly the flower stigma and stamen. Moreover, it was found that the promoter activity was enhanced by chilling, NaCl, GA, ACC and NAA, but inhibited by ABA, mannitol and PEG. In transgenic plants harboring 421 bp of the PsMPT promoter, the GUS gene expression and the activity were significantly increased by chilling treatment. When the fragment from -421 to -408 containing a MYC cis-element was deleted, the chilling response could not be observed. Further mutation analysis confirmed that the MYC element was one of the key motifs responding to chilling in the PsMPT promoter. The present study provides useful information for further investigation of the regulatory mechanism of PsMPT during the endo-dormancy release.

  13. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.

    Science.gov (United States)

    Lee, Ju-Hyun; Yu, W Haung; Kumar, Asok; Lee, Sooyeon; Mohan, Panaiyur S; Peterhoff, Corrinne M; Wolfe, Devin M; Martinez-Vicente, Marta; Massey, Ashish C; Sovak, Guy; Uchiyama, Yasuo; Westaway, David; Cuervo, Ana Maria; Nixon, Ralph A

    2010-06-25

    Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin-1 (PS1). In PS1 null blastocysts, neurons from mice hypomorphic for PS1 or conditionally depleted of PS1, substrate proteolysis and autophagosome clearance during macroautophagy are prevented as a result of a selective impairment of autolysosome acidification and cathepsin activation. These deficits are caused by failed PS1-dependent targeting of the v-ATPase V0a1 subunit to lysosomes. N-glycosylation of the V0a1 subunit, essential for its efficient ER-to-lysosome delivery, requires the selective binding of PS1 holoprotein to the unglycosylated subunit and the Sec61alpha/oligosaccharyltransferase complex. PS1 mutations causing early-onset AD produce a similar lysosomal/autophagy phenotype in fibroblasts from AD patients. PS1 is therefore essential for v-ATPase targeting to lysosomes, lysosome acidification, and proteolysis during autophagy. Defective lysosomal proteolysis represents a basis for pathogenic protein accumulations and neuronal cell death in AD and suggests previously unidentified therapeutic targets.

  14. Validity and Reliability of the Dutch Adaptation of the Psoriatic Arthritis Quality of Life (PsAQoL) Questionnaire

    NARCIS (Netherlands)

    Wink, Freke; Arends, Suzanne; McKenna, Stephen P; Houtman, Pieternella M; Brouwer, Elisabeth; Spoorenberg, Anneke

    2013-01-01

    Objective: The Psoriatic Arthritis Quality of Life (PsAQoL) questionnaire is a disease-specific instrument developed to measure quality of life (QoL) in patients with psoriatic arthritis (PsA). The aim of this study was to translate the measure into Dutch and to determine its psychometric

  15. Location-based prospective memory.

    Science.gov (United States)

    O'Rear, Andrea E; Radvansky, Gabriel A

    2018-02-01

    This study explores location-based prospective memory. People often have to remember to do things when in a particular location, such as buying tissues the next time they are in the supermarket. For event cognition theory, location is important for structuring events. However, because event cognition has not been used to examine prospective memory, the question remains of how multiple events will influence prospective memory performance. In our experiments, people delivered messages from store to store in a virtual shopping mall as an ongoing task. The prospective tasks were to do certain activities in certain stores. For Experiment 1, each trial involved one prospective memory task to be done in a single location at one of three delays. The virtual environment and location cues were effective for prospective memory, and performance was unaffected by delay. For Experiment 2, each trial involved two prospective memory tasks, given in either one or two instruction locations, and to be done in either one or two store locations. There was improved performance when people received instructions from two locations and did both tasks in one location relative to other combinations. This demonstrates that location-based event structure influences how well people perform on prospective memory tasks.

  16. PS Corner.

    Science.gov (United States)

    Woods, D. R.

    1984-01-01

    Reviews articles and books which focus on topics and strategies related to problem-solving. Also describes the Kepner-Tregoe industrial training program. This program contains many problem-solving ideas and strategies appropriate for the college level. (JN)

  17. Preliminary evaluation of PS300: A new self-lubricating high temperature composite coating for use to 800{degrees}C

    Energy Technology Data Exchange (ETDEWEB)

    DellaCorte, C.; Edmonds, B.J.

    1996-12-31

    This paper introduces PS300, a plasma sprayed, self-lubricating composite coating for use in sliding contacts at temperatures to 800{degrees}C. PS300 is a metal bonded chrome oxide coating with silver and BaF{sub 2}/CaF{sub 2} eutectic solid lubricant additives. PS300 is similar to PS200, a chromium carbide based coating; which is currently being investigated for a variety of tribological applications. In pin-on-disk testing up to 650{degrees}C, PS300 exhibited comparable friction and wear properties to PS200. The PS300 matrix, which is predominantly chromium oxide rather than chromium carbide, does not require diamond grinding and polishes readily with silicon carbide abrasives greatly reducing manufacturing costs compared to PS200. It is anticipated that PS300 has potential for sliding bearing and seal applications in both aerospace and general industry.

  18. Modeling and performance analysis of an improved movement-based location management scheme for packet-switched mobile communication systems.

    Science.gov (United States)

    Chung, Yun Won; Kwon, Jae Kyun; Park, Suwon

    2014-01-01

    One of the key technologies to support mobility of mobile station (MS) in mobile communication systems is location management which consists of location update and paging. In this paper, an improved movement-based location management scheme with two movement thresholds is proposed, considering bursty data traffic characteristics of packet-switched (PS) services. The analytical modeling for location update and paging signaling loads of the proposed scheme is developed thoroughly and the performance of the proposed scheme is compared with that of the conventional scheme. We show that the proposed scheme outperforms the conventional scheme in terms of total signaling load with an appropriate selection of movement thresholds.

  19. Effect of P/S ratio (0.5 vs 0.9) on hepatic LDL transport at three levels of dietary cholesterol in cynomolgus macaques

    International Nuclear Information System (INIS)

    Hunt, C.E.; Funk, G.M.; Turley, S.D.; Spady, D.K.; Dietschy, J.M.

    1990-01-01

    Interaction between dietary polyunsaturated to saturated (P/S) fatty acid ratio and cholesterol (C) was studied in 6 groups of male cynomolgus macaques fed diets (oleic acid constant) for 72 weeks as follows (C mg/Cal-P/S): (1), 0.06 - 0.5; (2), 0.06-0.9, (3), 0.28-0.5; (4), 0.28-0.9; (5), 2,35-0.5; (6), 2,35-0.9. Plasma C was proportional to dietary C and was affected significantly by P/S in 1 and 2 only. Mean plasma C (mg/dl) at 72 weeks was: (1) 158; (2) 117; (3) 320; (4) 284; (5) 602; (6) 601. LDL-C was significantly higher in (1) than in (2) (90 vs 65 mg/dl). In vivo LDL turnover studies showed that LDL clearance was suppressed by excess dietary C and by saturated fats in low C diets. Receptor-independent clearance was relatively constant. Hepatic LDL transport was determined after injection of 125I-cellobiose-LDL. Hepatic LDL-C uptake was greater in (2) than in (1). LDL-C synthesis was reduced in (4) and (6) compared to (3) and (5), respectively. The authors conclude that (i) hepatic LDL receptor activity is altered by degree of saturation in dietary triglycerides when dietary C is minimal and (ii) saturated triglycerides enhance LDL-C synthesis when dietary C is ample in this model

  20. Spectra and relaxation dynamics of the pseudohalide (PS) vibrational bands for Ru(bpy){sub 2}(PS){sub 2} complexes, PS = CN, NCS and N{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Compton, Ryan; Gerardi, Helen K. [Chemistry Division, Naval Research Laboratory, Washington, DC 20375 (United States); Weidinger, Daniel [SRA International, 4300 Fair Lakes Court, Fairfax, VA 22033 (United States); Brown, Douglas J. [Chemistry Department, US Naval Academy, Annapolis, MD 21402 (United States); Dressick, Walter J. [Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375 (United States); Heilweil, Edwin J. [Radiation and Biomolecular Physics Division, Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Owrutsky, Jeffrey C., E-mail: Jeff.Owrutsky@nrl.navy.mil [Chemistry Division, Naval Research Laboratory, Washington, DC 20375 (United States)

    2013-08-30

    Highlights: ► Static and transient infrared spectroscopy of pseudohalide bipyridine ruthenium complexes. ► Vibrational energy relaxes faster for the azide than the thiocyanate and cyanide analogs. ► Intramolecular vibrational relaxation is prevalent in cis-Ru(bpy){sub 2}(N{sub 3}){sub 2}. - Abstract: Static and transient infrared spectroscopy were used to investigate cis-Ru(bpy){sub 2}(N{sub 3}){sub 2} (bpy = 2,2′-bipyridine), cis-Ru(bpy){sub 2}(NCS){sub 2}, and cis-Ru(bpy){sub 2}(CN){sub 2} in solution. The NC stretching IR band for cis-Ru(bpy){sub 2}(NCS){sub 2} appears at higher frequency (∼2106 cm{sup −1} in DMSO) than for the free NCS{sup −} anion while the IR bands for the azide and cyanide complexes are closer to those of the respective free anions. The vibrational energy relaxation (VER) lifetime for the azide complex is found to be much shorter (∼5 ps) than for either the NCS or CN species (both ∼70 ps in DMSO) and the lifetimes resemble those for each corresponding free anion in solution. However, for cis-Ru(bpy){sub 2}(N{sub 3}){sub 2}, it is determined that the transition frequency depends more on the solvent than the VER lifetime implying that intramolecular vibrational relaxation is predominant over solvent energy-extracting interactions. These results are compared to the behavior of other related metal complexes in solution.

  1. Quarter Dates Location(s) Purpose Transportation and Travel ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    Dates. Location(s). Purpose. Transportation and Travel. Accommodation,. Meals and Other. Hospitality. Total. Expenses. Quarter 1. May 15. Ottawa, ON. Meetings. May 20 to 21. Washington DC. Conference. 11,364.93. 3,274.71. 53.50. 14,693.14. May 5 to June 5. Kenya and England. Meetings. June 18 to 21. Winnipeg, MB.

  2. Location Based Services and Applications

    OpenAIRE

    Elenis Gorrita Michel; Rónier Sierra Dávila; Samuel Montejo Sánchez

    2012-01-01

    Location Based Services (LBS) continue to grow in popularity, effectiveness and reliability, to the extent that applications are designed and implemented taking into account the facilities of the user location information. In this work, some of the main applications are addressed, in order to make an assessment of the current importance of the LBS, as a branch of technology in full swing. In addition, the main techniques for location estimation are studied, essential information to the LBS. B...

  3. Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells

    Energy Technology Data Exchange (ETDEWEB)

    Kinoshita, Taisuke [Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160-8582 (Japan); Nagamatsu, Go, E-mail: gonag@sc.itc.keio.ac.jp [Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160-8582 (Japan); Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012 (Japan); Kosaka, Takeo [Department of Urology, School of Medicine, Keio University, Tokyo 160-8582 (Japan); Takubo, Keiyo [Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160-8582 (Japan); Hotta, Akitsu [Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012 (Japan); Department of Reprogramming Science, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto (Japan); Ellis, James [Ontario Human iPS Cell Facility, Molecular Genetics, University of Toronto, Developmental and Stem Cell Biology, SickKids, Toronto, Canada MG1L7 (Canada); Suda, Toshio, E-mail: sudato@sc.itc.keio.ac.jp [Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160-8582 (Japan)

    2011-04-08

    Highlights: {yields} iPS cells were induced with a fluorescence monitoring system. {yields} ATM-deficient tail-tip fibroblasts exhibited quite a low reprogramming efficiency. {yields} iPS cells obtained from ATM-deficient cells had pluripotent cell characteristics. {yields} ATM-deficient iPS cells had abnormal chromosomes, which were accumulated in culture. -- Abstract: During cell division, one of the major features of somatic cell reprogramming by defined factors, cells are potentially exposed to DNA damage. Inactivation of the tumor suppressor gene p53 raised reprogramming efficiency but resulted in an increased number of abnormal chromosomes in established iPS cells. Ataxia-telangiectasia mutated (ATM), which is critical in the cellular response to DNA double-strand breaks, may also play an important role during reprogramming. To clarify the function of ATM in somatic cell reprogramming, we investigated reprogramming in ATM-deficient (ATM-KO) tail-tip fibroblasts (TTFs). Although reprogramming efficiency was greatly reduced in ATM-KO TTFs, ATM-KO iPS cells were successfully generated and showed the same proliferation activity as WT iPS cells. ATM-KO iPS cells had a gene expression profile similar to ES cells and WT iPS cells, and had the capacity to differentiate into all three germ layers. On the other hand, ATM-KO iPS cells accumulated abnormal genome structures upon continuous passages. Even with the abnormal karyotype, ATM-KO iPS cells retained pluripotent cell characteristics for at least 20 passages. These data indicate that ATM does participate in the reprogramming process, although its role is not essential.

  4. Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells

    International Nuclear Information System (INIS)

    Kinoshita, Taisuke; Nagamatsu, Go; Kosaka, Takeo; Takubo, Keiyo; Hotta, Akitsu; Ellis, James; Suda, Toshio

    2011-01-01

    Highlights: → iPS cells were induced with a fluorescence monitoring system. → ATM-deficient tail-tip fibroblasts exhibited quite a low reprogramming efficiency. → iPS cells obtained from ATM-deficient cells had pluripotent cell characteristics. → ATM-deficient iPS cells had abnormal chromosomes, which were accumulated in culture. -- Abstract: During cell division, one of the major features of somatic cell reprogramming by defined factors, cells are potentially exposed to DNA damage. Inactivation of the tumor suppressor gene p53 raised reprogramming efficiency but resulted in an increased number of abnormal chromosomes in established iPS cells. Ataxia-telangiectasia mutated (ATM), which is critical in the cellular response to DNA double-strand breaks, may also play an important role during reprogramming. To clarify the function of ATM in somatic cell reprogramming, we investigated reprogramming in ATM-deficient (ATM-KO) tail-tip fibroblasts (TTFs). Although reprogramming efficiency was greatly reduced in ATM-KO TTFs, ATM-KO iPS cells were successfully generated and showed the same proliferation activity as WT iPS cells. ATM-KO iPS cells had a gene expression profile similar to ES cells and WT iPS cells, and had the capacity to differentiate into all three germ layers. On the other hand, ATM-KO iPS cells accumulated abnormal genome structures upon continuous passages. Even with the abnormal karyotype, ATM-KO iPS cells retained pluripotent cell characteristics for at least 20 passages. These data indicate that ATM does participate in the reprogramming process, although its role is not essential.

  5. Effect of PS-K on long-term survival of primary lung cancer patients treated with radiation

    International Nuclear Information System (INIS)

    Okazaki, Atsushi; Nakajima, Nobuaki; Hayakawa, Kazushige; Saito, Yoshihiro; Mitomo, Osamu; Niibe, Hideo

    1984-01-01

    The effect of PS-K on long-term survival of primary lung cancer patients irradiated over 60 Gy through 1977 to 1982 was studied. PS-K was administrated orally 3.0 g, daily or intermittently in the pattern of 2 weeks per a month on patients of positive PPD skin test. All cases irradiated over 60 Gy were 174 (Group A) containing 62 cases with PS-K (Group B) and 112 cases without PS-K (Group C). Of group B, 44 cases were administrated within a month after curative irradiation (Group B1), 7 cases were administrated on time maintaining long-term good condition after irradiation (Group B2) and 11 cases were administrated after recognition of recurrence or metastasis (Group B3). Following results were obtained. 1. Obvious prolongation of survivals was recognized in the patients with PS-K after irradiation. (1) The cumulative 5 years survival rates of Group A, B 1 and C were 11.0%, 28.8% and 4.8%, respectively. (2) The cumulative 5 years survival rates of stage I,11 were 45.7% with PS-K and 10.7% without PS-K. (3) The cumulative 5 years survival rates of 21 cases matched age, sex, stage, histological type and tumor dose with and without PS-K were 37.8% and 7.2%. (4) In Group B 2, 5 cases out of 7 cases have been alived, but in Group B 3, satisfactory long-term survivals ware not obtained. 2. The necessary conditions which obtain long-term survival with PS-K were thought to be follows. One is that the tumor is brought almost to vanish by irradiation. Another is that the condition of host is superior to that of tumor in host-tumor relationship. 3. The possibility of intermittent administration of PS-K was suggested. (author)

  6. An analysis of seismic background noise variation and evaluation of detection capability of Keskin Array (BRTR PS-43) in Turkey

    Science.gov (United States)

    Bakir, M. E.; Ozel, N. M.; Semin, K. U.

    2011-12-01

    Bogazici University, Kandilli Observatory and Earthquake Research Institute (KOERI) is currently operating the Keskin seismic array (BRTR-PS 43) located in town Keskin, providing real-time data to IDC. The instrumentaion of seismic array includes six short period borehole seismometers and one broadband borehole seismometer. The seismic background noise variation of Keskin array are studied in order to estimate the local and regional event detection capability in the frequency range from 1 Hz to 10 Hz. The Power density spectrum and also probability density function of Keskin array data were computed for seasonal and diurnal noise variations between 2008 and 2010. The computation will be extended to cover the period between 2005 and 2008. We attempt to determine the precise frequency characteristics of the background noise, which will help us to assess the station sensitivity. Minimum detectable magnitude versus distance for Keskin seismic array will be analyzed based on the seismic noise analysis. Detailed analysis results of seismic background noise and detection capability will be presented by this research.

  7. Preliminary Specifications for the PS Pick-ups Amplifier to be used in the Transverse Damping System

    CERN Document Server

    Belleman, J; CERN. Geneva. AB Department

    2003-01-01

    The pick-up amplification stage to be used for the CODD in the PS is presently under redesign. It appears that the constraints for the circuit are very similar to those of the transverse feedback project. The AB/BDI group and in particular its PI section has kindly agreed to fulfil the RF group constraints so as to obtain a common design with a common control interface. The reliability aspect is not treated here. Nevertheless radiation has been considered. At the locations foreseen for the pick-ups (SS 2, 94, 98), the annual dose measured on the vacuum chamber (ref: CERN-TIS-2002-06-TE) is about 1000 Gray per year. This value is to be compared to the 100 Gy considered as the critical dose for electronic circuits. The radiation problem has been solved for the CODD pick-ups using distance and shield (active circuits 2 meters below the floor composed of concrete slabs). The same lay out will be applied for the dampers with the drawback of the capacitive plates being loaded with a low impedance -5 meters long- ca...

  8. Omega-conotoxin- and nifedipine-insensitive voltage-operated calcium channels mediate K(+)-induced release of pro-thyrotropin-releasing hormone-connecting peptides Ps4 and Ps5 from perifused rat hypothalamic slices.

    Science.gov (United States)

    Valentijn, K; Tranchand Bunel, D; Vaudry, H

    1992-07-01

    The rat thyrotropin-releasing hormone (TRH) precursor (prepro-TRH) contains five copies of the TRH progenitor sequence linked together by intervening sequences. Recently, we have shown that the connecting peptides prepro-TRH-(160-169) (Ps4) and prepro-TRH-(178-199) (Ps5) are released from rat hypothalamic neurones in response to elevated potassium concentrations, in a calcium-dependent manner. In the present study, the role of voltage-operated calcium channels in potassium-induced release of Ps4 and Ps5 was investigated, using a perifusion system for rat hypothalamic slices. The release of Ps4 and Ps5 stimulated by potassium (70 mM) was blocked by the inorganic ions Co2+ (2.6 mM) and Ni2+ (5 mM). In contrast, the stimulatory effect of KCl was insensitive to Cd2+ (100 microM). The dihydropyridine antagonist nifedipine (10 microM) had no effect on K(+)-evoked release of Ps4 and Ps5. Furthermore, the response to KCl was not affected by nifedipine (10 microM) in combination with diltiazem (1 microM), a benzothiazepine which increases the affinity of dihydropyridine antagonists for their receptor. The dihydropyridine agonist BAY K 8644, at concentrations as high as 1 mM, did not stimulate the basal secretion of Ps4 and Ps5. In addition, BAY K 8644 had no potentiating effect on K(+)-induced release of Ps4 and Ps5. The marine cone snail toxin omega-conotoxin, a blocker of both L- and N-type calcium channels had no effect on the release of Ps4 and Ps5 stimulated by potassium. Similarly, the omega-conopeptide SNX-111, a selective blocker of N-type calcium channels, did not inhibit the stimulatory effect of potassium. The release of Ps4 and Ps5 evoked by high K+ was insensitive to the non-selective calcium channel blocker verapamil (20 microM). Amiloride (1 microM), a putative blocker of T-type calcium channels, did not affect KCl-induced secretion of the two connecting peptides. Taken together, these results indicate that two connecting peptides derived from the pro-TRH, Ps

  9. Monitoring the US ATLAS Network Infrastructure with perfSONAR-PS

    CERN Document Server

    McKee, S; The ATLAS collaboration; Laurens, P; Severini, H; Wlodek, T; Wolff, S; Zurawski, J

    2012-01-01

    We will present our motivations for deploying and using the perfSONAR-PS Performance Toolkit at ATLAS sites in the United States and describe our experience in using it. This software creates a dedicated monitoring server, capable of collecting and performing a wide range of passive and active network measurements. Each independent instance is managed locally, but able to federate on a global scale; enabling a full view of the network infrastructure that spans domain boundaries. This information, available through web service interfaces, can easily be retrieved to create customized applications. USATLAS has developed a centralized “dashboard” offering network administrators, users, and decision makers the ability to see the performance of the network at a glance. The dashboard framework includes the ability to notify users (alarm) when problems are found, thus allowing rapid response to potential problems and making perfSONAR-PS crucial to the operation of our distributed computing infrastructure.

  10. Academic Training Lecture Regular Programme: Physics at the AD/PS/SPS

    CERN Multimedia

    2012-01-01

    Physics at the AD/PS/SPS (1/4), by Lau Gatignon (CERN).   Monday, June 18, 2012 from 11:00 to 12:00 (Europe/Zurich) at CERN ( 222-R-001 - Filtration Plant )   Lecture 1: The CERN injector complex and beams for non-LHC physics. The various machines and beam lines in the CERN injector complex are presented, from the linacs to the SPS. Special emphasis is given to the beam lines at the PS and SPS machines: AD, North and East Areas, nTOF and CNGS and HiRadMad as well as the ion beams. A short outlook is given to possible future upgrades and projects.   More information here.  

  11. Magnetic Waveform Measurements of the PS Injection Kicker KFA45 and Future Emittance Growth Estimates

    CERN Document Server

    Forte, Vincenzo; Ferrero Colomo, Alvaro; CERN. Geneva. ATS Department

    2018-01-01

    In the framework of the LHC Injectors Upgrade (LIU) project [1], this document summarises the beam-based measurement of the magnetic waveform of the PS injection kicker KFA45 [2], from data collected during several Machine Development (MD) sessions in 2016 and 2017. In the first part of the document, the measurement methodology is introduced and the results presented and compared with the specification required for a clean transfer of the bunches coming from the PSB after the upgrade. These measurements represent, to date, the only way to reconstruct the magnetic waveform. In the second part, kicker magnetic waveform PSpice®[3] simulations are compared and tuned to the measurements. Finally the simulated (validated through measurements) waveforms are used to estimate the future expected emittance growth for the different PS injection schemes, both for (LIU target) LHC and fixed target beams.

  12. High-Pressure Raman Scattering in the Layered Antiferromagnet NiPS_3

    Science.gov (United States)

    Rosenblum, S.; Merlin, R.; Francis, A. H.

    1996-03-01

    We report on two-magnon and vibrational Raman scattering from NiPS3 for pressures up to 30 GPa and temperatures between 110 and 300 K. NiPS3 is an S=1, two-dimensional antiferromagnet with TN = 150 K. It is the only known S=1 compound with a relative two-magnon linewidth comparable in magnitude to that of the parent compounds of the high temperature superconductors.(Rosenblum et al., Phys. Rev. B 49), 4352 (1994) In the cuprates, this anomalous linewidth is well described by phonon-magnon coupling.(Knoll et al.), Phys. Rev.B 42, 4842 (1990).^,(Nori et al., Phys. Rev. Lett. 75), 553 (1995). Here, we will look at the measured Grüneisen parameters of the vibrational and magnetic excitations and relate them to the magnetostrictive model.

  13. Sn ion energy distributions of ns- and ps-laser produced plasmas

    Science.gov (United States)

    Bayerle, A.; Deuzeman, M. J.; van der Heijden, S.; Kurilovich, D.; de Faria Pinto, T.; Stodolna, A.; Witte, S.; Eikema, K. S. E.; Ubachs, W.; Hoekstra, R.; Versolato, O. O.

    2018-04-01

    Ion energy distributions arising from laser-produced plasmas of Sn are measured over a wide laser parameter space. Planar-solid and liquid-droplet targets are exposed to infrared laser pulses with energy densities between 1 J cm‑2 and 4 kJ cm‑2 and durations spanning 0.5 ps to 6 ns. The measured ion energy distributions are compared to two self-similar solutions of a hydrodynamic approach assuming isothermal expansion of the plasma plume into vacuum. For planar and droplet targets exposed to ps-long pulses, we find good agreement between the experimental results and the self-similar solution of a semi-infinite simple planar plasma configuration with an exponential density profile. The ion energy distributions resulting from solid Sn exposed to ns-pulses agrees with solutions of a limited-mass model that assumes a Gaussian-shaped initial density profile.

  14. Comparación de la actividad psíquica humana desde una perspectiva evolutiva

    OpenAIRE

    Rosalía Montealegre

    1996-01-01

    Se parte de la teoría de la evolución de Darwin y se plantea: l. La acción de lo biológico y lo cultural en el desarrollo, analizada desde la psicología historicocultural, la etología humana, la sociobiología. Al centrarse este trabajo en la posición de la psicología historicocultural, se enfatiza lo cultural y el proceso de asimilación del desarrollo histórico de la sociedad por parte del individuo. 2. La actividad psíquica en primates, analizando lo psíquico desde la psicología ...

  15. As saídas para o trabalho psíquico da adolescência

    OpenAIRE

    Emmanuelli,Michèle

    2011-01-01

    O processo de adolescência coloca em questão o trabalho psíquico da elaboração do Édipo, do narcisismo e da problemática de separação. Como se desenvolvem estes processos ao longo do tempo e aonde é que eles chegam? A partir de romances propondo retratos da adolescência e de romances de juventude, de diários e de cartas da adolescência, mas também de pesquisas feitas com a metodologia projetiva junto a adolescentes e a criadores, o autor questiona o que se entende por « crescimento psíquico »...

  16. Supervision Application for the New Power Supply of the CERN PS (POPS)

    CERN Document Server

    Milcent, H; Gonzalez-Berges, M; Voitier, A

    2011-01-01

    The power supply system for the magnets of the CERN PS has been recently upgraded to a new system called POPS (POwer for PS). The old mechanical machine has been replaced by a system based on capacitors. The equipments as well as the low level controls have been provided by an external company (CONVERTEAM). The supervision application has been developed at CERN reusing the technologies and tools used for the LHC Accelerator and Experiments (UNICOS and JCOP frameworks, SIMATIC WinCC Open Architecture SCADA tool). The paper describes the full architecture of the control application, and the challenges faced for the integration with an outsourced system. The benefits of reusing the CERN industrial control frameworks and the required adaptations will be discussed. Finally, the initial operational experience will be presented.

  17. 80 kV electrostatic wire septum for AmPS

    International Nuclear Information System (INIS)

    Linden, A. van der; Bijleveld, J.H.M.; Rookhuizen, H.B.; Bruinsma, P.J.T.; Heine, E.; Lassing, P.; Prins, E.

    1992-01-01

    The Amsterdam Pulse Stretcher (AmPS) ring aims at a 100% duty cycle operation by means of slow extraction of injected electron beam pulses of 2.1 μs. In the extraction process of the AmPS, the extracted beam is intercepted from the circulating beam by the 1 m long electrostatic wire septum. For a bending angle of 4.4 mrad the maximum anode voltage is 80 kV. Care has been given to the electric field distribution at the entrance and exit of the septum and to the insulators, required to support the anode. Prototype tests have been successful up to an anode voltage of 120 kV. (R.P.) 9 refs.; 5 figs

  18. Location i det geopolitiske rum

    DEFF Research Database (Denmark)

    Agger, Gunhild

    2017-01-01

    Hovedformålet med artiklen er at undersøge forholdet mellem genrehåndtering og location i The Night Manager. Genren er thrilleren i den spionudgave, der er kendt fra tidligere John Le Carré-filmatiseringer. Location passer perfekt til genren med valget af glamourøse steder, der har kunnet bruges i...

  19. Improved Dynamic Planar Point Location

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Arge, Lars; Georgiadis, Loukas

    2006-01-01

    We develop the first linear-space data structures for dynamic planar point location in general subdivisions that achieve logarithmic query time and poly-logarithmic update time.......We develop the first linear-space data structures for dynamic planar point location in general subdivisions that achieve logarithmic query time and poly-logarithmic update time....

  20. Evolutionary economics and industry location

    NARCIS (Netherlands)

    Boschma, R.A.; Frenken, K.

    2003-01-01

    This paper aims to provide the outlines of an evolutionary economic geography of industry location. We discuss two evolutionary explanations of industry location, that is, one that concentrates on spin-offs, and one that focuses attention on knowledge and agglomeration economies. We claim that both

  1. Locations in television drama series

    DEFF Research Database (Denmark)

    Waade, Anne Marit

    in the extra bonus material (Gray, 2010; Waade, 2013), and film tours and film apps become part of the television series’ trans-media franchise (Reijnders, 2011; Thompson, 2007). Location has so far been a practical term describing the place where the series is shot. Ellis (1992) used to see location...

  2. Locations in Television Drama Series

    DEFF Research Database (Denmark)

    Waade, Anne Marit

    2017-01-01

    This special issue is dedicated to the analysis of the increasingly significant role of location as a key element in television drama. In recent years, the popularity of serial television has progressively been tied to the expanded use of location as a central element in productions, both as sett...... mainly been considered as a practical term in film and television productions....

  3. Family ties and residential locations

    NARCIS (Netherlands)

    Mulder, C.H.; Cooke, T.J.

    2009-01-01

    In this paper, and in the Special Issue it introduces, the focus is on the role of family ties in residential location choice and, conversely, the role of residential locations in maintaining family ties. Not only do events in the nuclear family trigger residential relocations, but nearby family

  4. The impact of 4Ps on Purchase Decision: A case of Apple in Hanoi, Vietnam

    OpenAIRE

    Bui Trung Thieu

    2016-01-01

    By using quantitative research methods and deductive reasoning, this research paper aims to address the importance of four marketing mix components (4Ps) on purchase decisions of customers of Apple Inc., by launching a survey in Hanoi, Vietnam, to generate primary data. The chosen sampling technique is quota sampling and several “quotas” were built. Descriptive analysis and hypothetical analysis (t-test, one-way ANOVA and Regression) using SPSS 20.0 are applied. Other implications of the rese...

  5. A simple improvement of the conventional cryopreservation for human ES and iPS cells

    OpenAIRE

    sprotocols

    2014-01-01

    Authors: Midori Ozawa, Yutaka Ozawa, Masashi Iemura, Arihiro Kohara, Kana Yanagihara & Miho K Furue ### Abstract In this study, a simple method for the cryopreservation of human embryonic stem (ES) and induced pluripotent stem (iPS) cells is proposed. It is based on the conventional slow-freezing method with 10% DMSO and modified mainly in a thawing protocol without specific equipment or reagents. Recovery rate of the cells cryopreserved by this method was equally high, which is compa...

  6. Upgraded DIRAC spectrometer at CERN PS for the investigation of pi pi and pi K atoms

    Czech Academy of Sciences Publication Activity Database

    Adeva, B.; Benelli, A.; Čechák, T.; Doškářová, P.; Hons, Zdeněk; Klusoň, J.; Lednický, Richard; Martinčík, J.; Průša, P.; Smolík, J.; Trojek, T.; Urban, T.; Vrba, T.

    2016-01-01

    Roč. 839, DEC (2016), s. 52-85 ISSN 0168-9002 R&D Projects: GA MŠk(CZ) LG13031 Institutional support: RVO:61389005 ; RVO:68378271 Keywords : upgraded DIRAC spectrometer * CERN PS * pi pi and pi K atoms * Life-time measurement * long-lived excited states of pi pi atoms Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders; BF - Elementary Particles and High Energy Physics (FZU-D) Impact factor: 1.362, year: 2016

  7. Cloud Computing for Pharmacometrics: Using AWS, NONMEM, PsN, Grid Engine, and Sonic.

    Science.gov (United States)

    Sanduja, S; Jewell, P; Aron, E; Pharai, N

    2015-09-01

    Cloud computing allows pharmacometricians to access advanced hardware, network, and security resources available to expedite analysis and reporting. Cloud-based computing environments are available at a fraction of the time and effort when compared to traditional local datacenter-based solutions. This tutorial explains how to get started with building your own personal cloud computer cluster using Amazon Web Services (AWS), NONMEM, PsN, Grid Engine, and Sonic.

  8. Information on antiprotonic atoms and the nuclear periphery from the PS209 experiment

    CERN Document Server

    Trzcinska, A.; Czosnyka, T.; von Egidy, T.; Gulda, K.; Hartmann, F.J.; Iwanicki, J.; Ketzer, B.; Kisielinski, M.; Klos, B.; Kurcewicz, W.; Lubinski, P.; Napiorkowski, P.J.; Pienkowski, L.; Schmidt, R.; Widmann, E.

    2001-01-01

    In the PS209 experiments at CERN two kinds of measurements were performed: the in-beam measurement of X-rays from antiprotonic atoms and the radiochemical, off-line determination of the yield of annihilation products with mass number A_t -1 (less by 1 than the target mass). Both methods give observables which allows to study the peripheral matter density composition and distribution.

  9. Loss of GABAergic inputs in APP/PS1 mouse model of Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Tutu Oyelami

    2014-04-01

    Full Text Available Alzheimer's disease (AD is characterized by symptoms which include seizures, sleep disruption, loss of memory as well as anxiety in patients. Of particular importance is the possibility of preventing the progressive loss of neuronal projections in the disease. Transgenic mice overexpressing EOFAD mutant PS1 (L166P and mutant APP (APP KM670/671NL Swedish (APP/PS1 develop a very early and robust Amyloid pathology and display synaptic plasticity impairments and cognitive dysfunction. Here we investigated GABAergic neurotransmission, using multi-electrode array (MEA technology and pharmacological manipulation to quantify the effect of GABA Blockers on field excitatory postsynaptic potentials (fEPSP, and immunostaining of GABAergic neurons. Using MEA technology we confirm impaired LTP induction by high frequency stimulation in APPPS1 hippocampal CA1 region that was associated with reduced alteration of the pair pulse ratio after LTP induction. Synaptic dysfunction was also observed under manipulation of external Calcium concentration and input-output curve. Electrophysiological recordings from brain slice of CA1 hippocampus area, in the presence of GABAergic receptors blockers cocktails further demonstrated significant reduction in the GABAergic inputs in APP/PS1 mice. Moreover, immunostaining of GAD65 a specific marker for GABAergic neurons revealed reduction of the GABAergic inputs in CA1 area of the hippocampus. These results might be linked to increased seizure sensitivity, premature death and cognitive dysfunction in this animal model of AD. Further in depth analysis of GABAergic dysfunction in APP/PS1 mice is required and may open new perspectives for AD therapy by restoring GABAergic function.

  10. CERN PS Optical Properties Measured with Turn-By-Turn Orbit Data

    CERN Document Server

    Bach, T; Giovannozzi, M; Hernalsteens, C; Lachaize, A; Sterbini, G; Tom´as, R; Wasef, R

    2013-01-01

    The performance of the CERN Proton Synchrotron (PS) has been constantly increasing over the years both in terms of beam parameters (intensity and brightness) and beam manipulations (transverse and longitudinal splitting). This implies a very good knowledge of the linear and non-linear model of the ring. In this paper we report on a detailed campaign of beam measurements based on turn-by-turn orbit data aimed at measuring the optics in several conditions as well as the resonance driving terms.

  11. Evidence for the existence of water:ethanol clusters from o-Ps yields

    International Nuclear Information System (INIS)

    Smith, F.A.; Beling, C.D.

    1982-01-01

    Lifetime measurements have been made in mixtures of water and ethanol at 293 K. Fluctuations are observed in both o-Ps yield and decay rate as a function of water concentration with local maxima occurring at molecular ratios (EtOH:H 2 O) of 4:1 and 1:1. The results are interpreted in terms of cluster formation at these concentrations. (Auth.)

  12. Measurement of betatron-tune in the KEK 12 GeV-PS/J-PARC

    International Nuclear Information System (INIS)

    Miura, Takako; Toyama, Takeshi; Igarashi, Susumu; Hayashi, Naoki

    2004-01-01

    Measurement of betatron-tune in the KEK 12 GeV-PS is performed by using band limited white noise which excites coherent betatron oscillations via stripline unit. We compared the results of the measurement for betatron oscillation amplitude with the result of calculation, and confirmed the consistency. The design of the tune-monitor in J-PARC was also discussed applying this result. (author)

  13. Induced pluripotent stem (iPS) cells from human fetal stem cells

    OpenAIRE

    Guillot, P. V.

    2016-01-01

    Pluripotency defines the ability of stem cells to differentiate into all the lineages of the three germ layers and self-renew indefinitely. Somatic cells can regain the developmental potential of embryonic stem cells following ectopic expression of a set of transcription factors or, in certain circumstances, via modulation of culture conditions and supplementation with small molecule, that is, induced pluripotent stem (iPS) cells. Here, we discuss the use of fetal tissues for reprogramming, f...

  14. A 3 ps synchronised multi-frame photographic diagnostic for target experiments with the iodine laser

    International Nuclear Information System (INIS)

    Maaswinkel, A.G.M.; Sigel, R.; Baumhacker, H.; Brederlow, G.

    1982-10-01

    A laser system is described with which we obtain a sequence of 6 pictures (interferograms or shadowgrams) of the plasma produced by the iodine laser on solid targets. The system consists of a synchronously pumped dye laser amplified in dye cells pumped by an excimer laser. It delivers a pulse with an energy of 400 μJ and a length of 3 ps at a wavelength of 580 nm that is highly synchronous with the iodine pulse. (orig.)

  15. Uncapacitated facility location problems: contributions

    Directory of Open Access Journals (Sweden)

    Galvão Roberto Diéguez

    2004-01-01

    Full Text Available The objective of the present paper is to review my personal contributions in the field of uncapacitated facility location problems. These contributions took place throughout my academic career, from the time I was a Ph.D. student at Imperial College to the present day. They cover approximately 30 years, from 1973 to 2003; they address: algorithms developed for the p-median problem and for a general formulation of uncapacitated location problems; the study of dynamic location models; covering and hierarchical location problems; queuing-based probabilistic location models. The contributions encompass theoretical developments, computational algorithms and practical applications. All work took place in an academic environment, with the invaluable collaboration of colleagues (both in Brazil and abroad and research students at COPPE. Each section in the paper is dedicated to a topic that involves a personal contribution. Every one of them is placed within the context of the existing literature.

  16. Modeling discrete competitive facility location

    CERN Document Server

    Karakitsiou, Athanasia

    2015-01-01

    This book presents an up-to-date review of modeling and optimization approaches for location problems along with a new bi-level programming methodology which captures the effect of competition of both producers and customers on facility location decisions. While many optimization approaches simplify location problems by assuming decision making in isolation, this monograph focuses on models which take into account the competitive environment in which such decisions are made. New insights in modeling, algorithmic and theoretical possibilities are opened by this approach and new applications are possible. Competition on equal term plus competition between market leader and followers are considered in this study, consequently bi-level optimization methodology is emphasized and further developed. This book provides insights regarding modeling complexity and algorithmic approaches to discrete competitive location problems. In traditional location modeling, assignment of customer demands to supply sources are made ...

  17. Bioremediation potential of a newly isolate solvent tolerant strain Bacillus thermophilus PS11

    Directory of Open Access Journals (Sweden)

    PAYEL SARKAR

    2012-01-01

    Full Text Available The increased generation of solvent waste has been stated as one of the most critical environmental problems. Though microbial bioremediation has been widely used for waste treatment but their application in solvent waste treatment is limited since the solvents have toxic effects on the microbial cells. A solvent tolerant strain of Bacillus thermophilus PS11 was isolated from soil by cyclohexane enrichment. Transmission electron micrograph of PS11 showed convoluted cell membrane and accumulation of solvents in the cytoplasm, indicating the adaptation of the bacterial strain to the solvent after 48h of incubation. The strain was also capable of growing in presence of wide range of other hydrophobic solvents with log P-values below 3.5. The isolate could uptake 50 ng/ml of uranium in its initial 12h of growth, exhibiting both solvent tolerance and metal resistance property. This combination of solvent tolerance and metal resistance will make the isolated Bacillus thermophilus PS11 a potential tool for metal bioremediation in solvent rich wastewaters.

  18. Prevention of Infectious Mastitis by Oral Administration of Lactobacillus salivarius PS2 During Late Pregnancy.

    Science.gov (United States)

    Fernández, Leónides; Cárdenas, Nivia; Arroyo, Rebeca; Manzano, Susana; Jiménez, Esther; Martín, Virginia; Rodríguez, Juan Miguel

    2016-03-01

    Previous studies have shown that oral administration of lactobacilli can be an efficient approach to treat lactational infectious mastitis. In this trial, we have evaluated the potential of Lactobacillus salivarius PS2 to prevent this condition when orally administered during late pregnancy to women who had experienced infectious mastitis after previous pregnancies. In this study, 108 pregnant women were randomly assigned to one of 2 groups. Those in the probiotic group (n = 55) ingested daily 9 log10 colony-forming units of L. salivarius PS2 from approximately week 30 of pregnancy until delivery, whereas those in the placebo group (n = 53) received a placebo. The occurrence of mastitis was evaluated during the first 3 months after delivery. Globally, 44 of 108 women (41%) developed mastitis; however, the percentage of women with mastitis in the probiotic group (25% [n = 14]) was significantly lower than in the control group (57% [n = 30]). When mastitis occurred, the milk bacterial counts in the probiotic group were significantly lower than those obtained in the placebo group. Oral administration of L. salivarius PS2 during late pregnancy appears to be an efficient method to prevent infectious mastitis in a susceptible population. NCT01505361. © The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  19. Optical design of beam lines at the KEK-PS new experimental hall

    International Nuclear Information System (INIS)

    Tanaka, K.H.; Ieiri, M.; Noumi, H.; Minakawa, M.; Yamanoi, Y.; Kato, Y.; Ishii, H.; Suzuki, Y.; Takasaki, M.

    1995-01-01

    A new counter experimental hall [K.H. Tanaka et al., IEEE Trans. Magn. 28 (1992) 697] was designed and constructed at the KEK 12-GeV Proton Synchrotron (KEK-PS). The extracted proton beam from the KEK-PS is introduced to the new hall through the newly-prepared primary beam line, EP1, and hits two production targets in cascade. The upstream target provides secondary particles to the low momentum (0.4-0.6 GeV/c) separated beam line, K5, and the downstream target is connected to the medium momentum (0.6-2.0 GeV/c) separated beam line, K6. Several new ideas were employed in the beam optical designs of EP1, K5 and K6 in order to increase the number and the purity of the short-lived secondary particles, such as kaons and pions, under the limited energy and intensity of the primary protons provided by the KEK-PS. These new ideas are described in this paper as well as the first commissioning results. (orig.)

  20. Quantitative analysis of intraneuronal transport in human iPS neurons

    Directory of Open Access Journals (Sweden)

    Haruko Nakamura

    2015-08-01

    Full Text Available Induced pluripotent stem (iPS cells are promising tools to investigate disease mechanism and develop new drugs. Intraneuronal transport, which is fundamental for neuronal survival and function, is vulnerable to various pharmacological and chemical agents and is disrupted in some neurodegenerative disorders. We applied a quantification method for axonal transport by counting CM-DiI–labeled particles traveling along the neurite, which allowed us to monitor and quantitate, for the first time, intraneuronal transport in human neurons differentiated from iPS cells (iCell neurons. We evaluated the acute effects of several anti-neoplastic agents that have been previously shown to affect intraneuronal transport. Vincristine, paclitaxel and oxaliplatin decreased the number of moving particle along neurites. Cisplatin, however, produced no effect on intraneuronal transport, which is in contrast to our previous report indicating that it inhibits transport in chick dorsal root ganglion neurons. Our system may be a useful method for assessing intraneuronal transport and neurotoxicity in human iPS neurons.