Microprocessor-based system for continuous monitoring of radiation levels around the CERN PS and PSB accelerators

Energy Technology Data Exchange (ETDEWEB)

Agoritsas, V.; Beck, F.; Benincasa, G.P.; Bovigny, J.P.

1986-06-01

This paper describes a new beam loss monitor system which has been installed in the PS and PSB machines, replacing an earlier system. The new system is controlled by a microprocessor which can operate independently of the accelerator control system, though setting up and central display are usually done remotely, using the standard control system facilities.

PS overcomes two serious magnet failures

CERN Multimedia

Maximilien Brice

2003-01-01

Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. Here we see the PS magnet string awaiting the replacement no. 6 magnet.

Risk Management Capability Maturity and Performance of Complex Product and System (CoPS Projects with an Asian Perspective

Directory of Open Access Journals (Sweden)

Ren, Y.

2014-07-01

Full Text Available Complex Products and Systems (CoPS are high value, technology and engineering-intensive capital goods. The motivation of this study is the persistent high failure rate of CoPS projects, Asian CoPS provider’s weak capability and lack of specific research on CoPS risk management. This paper evaluates risk management maturity level of CoPS projects against a general CoPS risk management capability maturity model (RM-CMM developed by the authors. An Asian based survey was conducted to investigate the value of RM to project performance, and Asian (non-Japanese CoPS implementers’ perceived application of RM practices, their strengths and weaknesses. The survey result shows that higher RM maturity level leads to higher CoPS project performance. It also shows project complexity and uncertainty moderates the relationship between some RM practices and project performance, which implies that a contingency approach should be adopted to manage CoPS risks effectively. In addition, it shows that Asian CoPS implementers are weak in RM process and there are also rooms for improvement in the softer aspects of organizational capabilities and robustness.

The PS Booster hits 40

CERN Multimedia

Joannah Caborn Wengler

2012-01-01

Many accelerators’ "round" birthdays are being celebrated at CERN these days – the PS turned 50 in 2009, the SPS was 35 in 2011, and this year it's the turn of the PS Booster to mark its 40th anniversary. Originally designed to accelerate 1013 protons to 800 MeV, it has far exceeded its initial design performance over the years.   The PS Booster in the 1970s. Imagine the scene: a group of accelerator physicists staring expectantly at a monitor, when suddenly a shout of joy goes up as a signal flickers across the screen. Does that sound familiar? Well, turn the clock back 40 years (longer hair, wider trouser legs) and you have the situation at the PS Booster on 26 May 1972. On that day, beam was injected into the Booster for the first time. “It was a real buzz,” says Heribert Koziol, then Chairman of the Running-in Committee. “We were very happy – and also a little relieved – when the beam finally...

A microprocessor-based system for continuous monitoring of radiation levels around the CERN PS and PSB accelerators

Science.gov (United States)

Agoritsas, V.; Beck, F.; Benincasa, G. P.; Bovigny, J. P.

1986-06-01

This paper describes a new beam loss monitor system which has been installed in the PS and PSB machines, replacing an earlier system. The new system is controlled by a microprocessor which can operate independently of the accelerator control system, though setting up and central display are usually done remotely, using the standard control system facilities.

PS overcomes two serious magnet failures

CERN Multimedia

Maximilien Brice

2003-01-01

Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. These pictures show one of the magnets (no. 19) on the PS locomotive brought back into service for the removal and replacement operations.

Spectra and relaxation dynamics of the pseudohalide (PS) vibrational bands for Ru(bpy){sub 2}(PS){sub 2} complexes, PS = CN, NCS and N{sub 3}

Energy Technology Data Exchange (ETDEWEB)

Compton, Ryan; Gerardi, Helen K. [Chemistry Division, Naval Research Laboratory, Washington, DC 20375 (United States); Weidinger, Daniel [SRA International, 4300 Fair Lakes Court, Fairfax, VA 22033 (United States); Brown, Douglas J. [Chemistry Department, US Naval Academy, Annapolis, MD 21402 (United States); Dressick, Walter J. [Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375 (United States); Heilweil, Edwin J. [Radiation and Biomolecular Physics Division, Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Owrutsky, Jeffrey C., E-mail: Jeff.Owrutsky@nrl.navy.mil [Chemistry Division, Naval Research Laboratory, Washington, DC 20375 (United States)

2013-08-30

Highlights: ► Static and transient infrared spectroscopy of pseudohalide bipyridine ruthenium complexes. ► Vibrational energy relaxes faster for the azide than the thiocyanate and cyanide analogs. ► Intramolecular vibrational relaxation is prevalent in cis-Ru(bpy){sub 2}(N{sub 3}){sub 2}. - Abstract: Static and transient infrared spectroscopy were used to investigate cis-Ru(bpy){sub 2}(N{sub 3}){sub 2} (bpy = 2,2′-bipyridine), cis-Ru(bpy){sub 2}(NCS){sub 2}, and cis-Ru(bpy){sub 2}(CN){sub 2} in solution. The NC stretching IR band for cis-Ru(bpy){sub 2}(NCS){sub 2} appears at higher frequency (∼2106 cm{sup −1} in DMSO) than for the free NCS{sup −} anion while the IR bands for the azide and cyanide complexes are closer to those of the respective free anions. The vibrational energy relaxation (VER) lifetime for the azide complex is found to be much shorter (∼5 ps) than for either the NCS or CN species (both ∼70 ps in DMSO) and the lifetimes resemble those for each corresponding free anion in solution. However, for cis-Ru(bpy){sub 2}(N{sub 3}){sub 2}, it is determined that the transition frequency depends more on the solvent than the VER lifetime implying that intramolecular vibrational relaxation is predominant over solvent energy-extracting interactions. These results are compared to the behavior of other related metal complexes in solution.

LS1 Report: PS beams are back!

CERN Multimedia

Katarina Anthony & Anaïs Schaeffer

2014-01-01

For the first time in over 15 months, there are beams back in the PS. Making their first tour of the accelerator today, 20 June, their injection marks the end of weeks of cold checkouts and hardware commissioning in the PS.   The CERN Control Centre (CCC) is back in business: people gather to restart the LHC injectors, today the PS. Since hardware commissioning was wrapped up on 23 May, the Operations Group (BE-OP) has been conducting cold checkouts on the PS. This involves switching on all of the machine's systems, verifying that they respond to commands by OP and ensuring they are calibrated to beam timings. "These verifications were done, in part, during the hardware commissioning dry runs," says Rende Steerenberg, PS section leader. "But the cold checkouts are on a much larger scale, as we act as if there is beam in the whole machine. We placed a full load on the controls system, cooling, networks, etc. in order to setup the accelerator in the most realis...

The PS will soon be back in operation

CERN Multimedia

2006-01-01

The PS's power supply system is undergoing repairs for the accelerator to restart on 26 June. The AB Department's Power Converter Group is working flat out with Siemens to return the PS's power supply system to working order. A problem appeared on the insulation of the power cables of the rotor of the rotating machine (photo) which supplies power to the PS magnets. To prevent more significant damage to the rotating machine, the AB Department, with the approval of the CERN Management, decided to shut down the PS which had started running on 15 May. Everything is being done to restart the accelerator on 26 June. The PS's rotating machine comprises a motor coupled to a generator. The generator's rotor acts like a flywheel, supplying high-power pulses of 40 to 50 megawatts to the PS magnets. The 6 megawatt motor drives the installation at 1000 revolutions per minute and compensates only for variations in speed. It is an essential interface since it would be hard to imagine connecting such an electrical charge, p...

Supervision Software for the Integration of the Beam Interlock System with the CERN Accelerator Complex

CERN Document Server

Audrain, M; Dragu, M; Fuchsberger, K; Garnier, JC; Gorzawski, AA; Koza, M; Krol, K; Moscatelli, A; Puccio, B; Stamos, K; Zerlauth, M

2014-01-01

The Accelerator complex at the European Organisation for Nuclear Research (CERN) is composed of many systems which are required to function in a valid state to ensure safe beam operation. One key component of machine protection, the Beam Interlock System (BIS), was designed to interface critical systems around the accelerator chain, provide fast and reliable transmission of beam dump requests and trigger beam extraction in case of malfunctioning of equipment systems or beam losses. Numerous upgrades of accelerator and controls components during the Long Shutdown 1 (LS1) are followed by subsequent software updates that need to be thoroughly validated before the restart of beam operation in 2015. In parallel, the ongoing deployments of the BIS hardware in the PS booster (PSB) and the future LINAC4 give rise to new requirements for the related controls and monitoring software due to their fast cycle times. This paper describes the current status and ongoing work as well as the long-term vision for the integratio...

General man-machine interface used in accelerators controls

International Nuclear Information System (INIS)

Boutheon, M.; Di Maio, F.; Pace, A.

1992-01-01

A large community is now using Workstations as Accelerators Computer Controls Interface, through the concepts of windows - menus - synoptics - icons. Some standards were established for the CERN-PS control systems rejuvenation. The Booster-to-PS transfer and injection process is now entirely operated with these tools. This application constitutes a global environment providing the users with the controls, analysis, visualization of a part of an accelerator. Individual commands, measurements, and specialized programs including complex treatments are available in a homogeneous frame. Some months of experience in current operation have shown that this model can be extended to the whole project. (author)

PsB multiprotein complex of Dictyostelium discoideum. Demonstration of cellulose binding activity and order of protein subunit assembly.

Science.gov (United States)

McGuire, V; Alexander, S

1996-06-14

The differentiated spores of Dictyostelium are surrounded by an extracellular matrix, the spore coat, which protects them from environmental factors allowing them to remain viable for extended periods of time. This presumably is a major evolutionary advantage. This unique extracellular matrix is composed of cellulose and glycoproteins. Previous work has shown that some of these spore coat glycoproteins exist as a preassembled multiprotein complex (the PsB multiprotein complex) which is stored in the prespore vesicles (Watson, N., McGuire, V., and Alexander, S (1994) J. Cell Sci. 107, 2567-2579). Later in development, the complex is synchronously secreted from the prespore vesicles and incorporated into the spore coat. We now have shown that the PsB complex has a specific in vitro cellulose binding activity. The analysis of mutants lacking individual subunits of the PsB complex revealed the relative order of assembly of the subunit proteins and demonstrated that the protein subunits must be assembled for cellulose binding activity. These results provide a biochemical explanation for the localization of this multiprotein complex in the spore coat.

Proceedings of the workshop on the PS-spin collider

International Nuclear Information System (INIS)

Mori, Yoshiharu

1993-05-01

This volume is a record of the PS-Spin Collider Workshop which was held at KEK, Jan. 31-Feb.1, 1992. As a future project of the KEK 12-GeV proton synchrotron (KEK-PS), the hadron collider (PS-Collider), has been under discussion. Originally, the PSC was designed for heavy ion beam collisions with the energy range of 5-7 GeV/u. If polarized protons are accelerated in PSC, 19 x 19 GeV collisions are possible. This workshop was proposed to bring together interested experimentalists and accelerator physicists to discuss the case that could be made for polarization physics and the technical feasibility at the PS Spin Collider. More than 30 physicists participated in the workshop and very interesting and useful discussions took place. (author)

Access systems strategy in the accelerator complex and experimental areas

International Nuclear Information System (INIS)

Nunes, R.; Ninin, P.; Sanchez-Corral, E.; Ladzinski, T.

2012-01-01

This paper reviews the main features of the new PS Personnel Protection System (PSPSS) as well as the main milestones for its deployment during the Long Shutdown of 2013-2014. Access conditions in the PS, SPS and LHC complexes during this period shall be described as well as the upgrades and improvements that are under preparation. (authors)

Technical training: AXEL-2009 - Introduction to Particle Accelerators

CERN Multimedia

HR Department

2009-01-01

CERN Technical Training 2009: Learning for the LHC! AXEL-2009 is a course series on particle accelerators, given at CERN within the framework of the 2009 Technical Training Program. Known in the past as the PS Complex Operation Course (or the ‘PS Shutdown Course’), the general accelerator physics module as been organized since 2003 as a joint venture between the AB Department and Technical Training Service, and is open to a wider CERN community. The AXEL-2009 course series is designed for technicians who are operating an accelerator, or whose work is closely linked to accelerators, but it is also open to technicians, engineers, and physicists interested in this field. The course does not require any prior knowledge of accelerators. However, some basic knowledge of trigonometry, matrices and differential equations, and some basic notions of magnetism would be an advantage. The course series will be composed of 10 one-hour lectures (mornings and afternoons) from 19 to 23 January 2009, and will be given i...

Technical Training: AXEL-2005 - Introduction to Particle Accelerators

CERN Multimedia

Monique Duval

2005-01-01

CERN Technical Training 2005: Learning for the LHC! AXEL-2005 is a course series on particle accelerators, given at CERN within the framework of the 2005 Technical Training Programme. Known in the past as the PS Complex Operation Course (or the 'PS Shutdown Course', now AB/OP), the general accelerator physics section is organised since 2003 as a joint venture between the AB department and Technical Training, and is open to a wider CERN community. The AXEL-2005 course series is designed for technicians who are operating an accelerator, or whose work is closely linked to accelerators, but it is open to all people (technicians, engineers, physicists) interested in this field. The course does not require any prior knowledge on accelerators. However, some basic knowledge on trigonometry, matrices and differential equations, and some basic notions of magnetism would be an advantage. The course will be given in French on course supports in English; questions and answers possible in both languages. AXEL-2005 - I...

Technical training: AXEL-2006 - Introduction to Particle Accelerators

CERN Multimedia

Davide Vitè

2006-01-01

CERN Technical Training 2006: Learning for the LHC! AXEL-2006 is a course series on particle accelerators, given at CERN within the framework of the 2006 Technical Training Programme. Known in the past as the PS Complex Operation Course (or the 'PS Shutdown Course'), the general accelerator physics module is organised since 2003 as a joint venture between the AB department and Technical Training, and is open to a wider CERN community. The AXEL-2006 course series is designed for technicians who are operating an accelerator, or whose work is closely linked to accelerators, but it is open to technicians, engineers, and physicists interested in this field. The course does not require any prior knowledge on accelerators. However, some basic knowledge on trigonometry, matrices and differential equations, and some basic notions of magnetism would be an advantage. The course series will be composed of 10 one-hour lectures (mornings and afternoons) during the week 6-10 February March 2006, and given in English...

Technical Training: AXEL-2005: Introduction to Particle Accelerators

CERN Multimedia

Monique Duval

2005-01-01

CERN Technical Training 2005: Learning for the LHC! AXEL-2005 is a course series on particle accelerators, given at CERN within the framework of the 2005 Technical Training Programme. Known in the past as the PS Complex Operation Course (or the 'PS Shutdown Course', now AB/OP), the general accelerator physics section is organised since 2003 as a joint venture between the AB department and Technical Training, and is open to a wider CERN community. The AXEL-2005 course series is designed for technicians who are operating an accelerator, or whose work is closely linked to accelerators, but it is open to all people (technicians, engineers, physicists) interested in this field. The course does not require any prior knowledge on accelerators. However, some basic knowledge on trigonometry, matrices and differential equations, and some basic notions of magnetism would be an advantage. The course series will be composed of 10 one-hour lectures (mornings and afternoons) during the week 14-18 March 2005, given in Fr...

Technical training: AXEL-2009 - Introduction to Particle Accelerators

CERN Multimedia

HR Department

2008-01-01

CERN Technical Training 2009: Learning for the LHC! AXEL-2009 is a course series on particle accelerators, given at CERN within the framework of the 2009 Technical Training Program. Known in the past as the PS Complex Operation Course (or the ‘PS Shutdown Course’), the general accelerator physics module is organized since 2003 as a joint venture between the AB department and Technical Training, and is open to a wider CERN community. The AXEL-2009 course series is designed for technicians who are operating an accelerator, or whose work is closely linked to accelerators, but it is open to technicians, engineers, and physicists interested in this field. The course does not require any prior knowledge on accelerators. However, some basic knowledge on trigonometry, matrices and differential equations, and some basic notions of magnetism would be an advantage. The course series will be composed of 10 one-hour lectures (mornings and afternoons) from the 19th – 23rd of January 2009, and given in English with...

Technical training: AXEL-2010 - Introduction to particle accelerators

CERN Multimedia

HR Department

2010-01-01

CERN Technical Training 2010: Learning for the LHC! AXEL-2010 is a course series on particle accelerators, given at CERN within the framework of the 2010 Technical Training Program. Known in the past as the PS Complex Operation Course (or the ‘PS Shutdown Course’), the general accelerator physics module is organized since 2003 as a joint venture between the BE department and Technical Training, and is open to a wider CERN community. The AXEL-2010 course series is designed for technicians who are operating an accelerator, or whose work is closely linked to accelerators, but it is open to technicians, engineers, and physicists interested in this field. The course does not require any prior knowledge on accelerators. However, some basic knowledge on trigonometry, matrices and differential equations, and some basic notions of magnetism would be an advantage. The course series will be composed of 10 one-hour lectures (mornings and afternoons) from the 1st – 5th of February 201...

Proposal for a Simplified Management of Accelerator Settings in the Injector Complex Based on Automatic Setting Propagation

CERN Document Server

Damerau, Heiko

2018-01-01

With the increasing number of beams with different characteristics the number of controls settings to pilot the accelerator hardware has grown proportionally. In addition new hardware often comes with more possibilities to configure its behaviour, also requiring more parameters to be set. Both factors have lead to a significant growth of the number of set values to control the accelerators in the injector complex. To keep track of this myriad of settings, an automatic setting propagation mechanism is suggested. It allows to group cycles in families which partly share the same settings. This is in particular efficient for cycles where most of the settings must be identical, which is the case for many beams, e.g., in the PS.

PS auxiliary magnet

CERN Multimedia

CERN PhotoLab

1974-01-01

Units of the PS auxiliary magnet system. The picture shows how the new dipoles, used for vertical and horizontal high-energy beam manipulation, are split for installation and removal so that it is not necessary to break the accelerator vacuum. On the right, adjacent to the sector valve and the windings of the main magnet, is an octupole of the set.

Enhanced personal protection at the PS

CERN Multimedia

Samuel Morier Genoud

2013-01-01

Pictures 03, 06, 07 08 : Pierre Ninin, deputy group leader of GS-ASE and responsible for the installation of the new PS complex safety system, in front of a new access control system.Pictures 10, 12 ,13 : View of Building 271, the future control centre of the new PS complex safety system.

A great start for the whole CERN accelerator chain

CERN Multimedia

2016-01-01

With physics data-taking under way this week at the LHC, I’d like to take a look at what’s been happening at the rest of the CERN accelerator chain.   The LHC tends to dominate the news from CERN for all kinds of reasons, beech martens included, but we should not forget that there is a unique chain of accelerators upstream of the LHC, tended to and operated by an incredible group of people. If our whole accelerator chain does not work perfectly, nor can the LHC, and in addition to forming the LHC’s injector chain, our upstream accelerators support their own experiments, bringing great diversity to the CERN research programme. The chain begins with the proton source and Linac2, which have been faithfully delivering beams since 1978. This year, Linac2 accelerated its first beams on 29 February. Beams were then passed on to the PS Booster and the veteran PS, the linchpin of the CERN accelerator complex and in operation since 1959. The final link in the chain before the ...

Gamma Transition Jump for PS2

CERN Document Server

Bartmann, W; Métral, E; Möhl, D; Peggs, S

2008-01-01

The PS2, which is proposed as a replacement for the existing ~50-year old PS accelerator, is presently considered to be a normal conducting synchrotron with an injection kinetic energy of 4 GeV and a maximum energy of 50 GeV. One of the possible lattices (FODO option) foresees crossing of transition energy near 10 GeV. Since the phase-slip-factor $\\eta$ becomes very small near transition energy, many intensity dependent effects can take place in both longitudinal and transverse planes. The aim of the present paper is on the one hand to scale the gamma transition jump, used since 1973 in the PS, to the projected PS2 and on the other hand based on these results the analysis of the implementation and feasibility of a gamma transition jump scheme in a conventional FODO lattice.

GABA(A receptor-mediated acceleration of aging-associated memory decline in APP/PS1 mice and its pharmacological treatment by picrotoxin.

Directory of Open Access Journals (Sweden)

Yuji Yoshiike

Full Text Available Advanced age and mutations in the genes encoding amyloid precursor protein (APP and presenilin (PS1 are two serious risk factors for Alzheimer's disease (AD. Finding common pathogenic changes originating from these risks may lead to a new therapeutic strategy. We observed a decline in memory performance and reduction in hippocampal long-term potentiation (LTP in both mature adult (9-15 months transgenic APP/PS1 mice and old (19-25 months non-transgenic (nonTg mice. By contrast, in the presence of bicuculline, a GABA(A receptor antagonist, LTP in adult APP/PS1 mice and old nonTg mice was larger than that in adult nonTg mice. The increased LTP levels in bicuculline-treated slices suggested that GABA(A receptor-mediated inhibition in adult APP/PS1 and old nonTg mice was upregulated. Assuming that enhanced inhibition of LTP mediates memory decline in APP/PS1 mice, we rescued memory deficits in adult APP/PS1 mice by treating them with another GABA(A receptor antagonist, picrotoxin (PTX, at a non-epileptic dose for 10 days. Among the saline vehicle-treated groups, substantially higher levels of synaptic proteins such as GABA(A receptor alpha1 subunit, PSD95, and NR2B were observed in APP/PS1 mice than in nonTg control mice. This difference was insignificant among PTX-treated groups, suggesting that memory decline in APP/PS1 mice may result from changes in synaptic protein levels through homeostatic mechanisms. Several independent studies reported previously in aged rodents both an increased level of GABA(A receptor alpha1 subunit and improvement of cognitive functions by long term GABA(A receptor antagonist treatment. Therefore, reduced LTP linked to enhanced GABA(A receptor-mediated inhibition may be triggered by aging and may be accelerated by familial AD-linked gene products like Abeta and mutant PS1, leading to cognitive decline that is pharmacologically treatable at least at this stage of disease progression in mice.

GSK3 beta forms a tetrameric complex with endogenous PS1-CTF/NTF and beta-catenin. Effects of the D257/D385A and FAD-linked mutations.

Science.gov (United States)

Tesco, G; Tanzi, R E

2000-01-01

We have previously shown that the endogenous C-terminal fragment of presenilin 1 co-immunoprecipitates with endogenous beta-catenin. Since PS1 has been suggested to be involved in beta-catenin stabilization, we further investigated whether GSK3 beta, responsible for beta-catenin phosphorylation and degradation, is part of the PS1/beta-catenin complex. In naïve H4 and CHO cells, PS1 co-immunoprecipitated with both endogenous beta-catenin and GSK3 beta. In addition, GSK3 beta endogenously binds to the PS1-CTF/NTF complex and beta-catenin in naïve CHO cells. GSK3 beta also co-immunoprecipitated with PS1 full length in CHO cell lines overexpressing PS1 wild type. Given that it has been recently shown that PS1 mutations of aspartate 257 or 385 result in prevention of PS1 endoproteolysis and inhibition of gamma-secretase activity, we also tested whether PS1 endoproteolysis is required for beta-catenin/GSK3 beta/PS1 binding and whether PS1 FAD-linked mutations affect GSK3 beta recruitment in the PS1/beta-catenin complex. GSK3 beta was detected in PS1 immunoprecipitates from H4 cell lines overexpressing PS1 wild type, delta E10, A286E, L246V and in CHO cell lines overexpressing aspartate or M146L mutations. The latter data show that the absence of PS1 endoproteolysis (D257A/D385A and delta E10) or the presence of PS1-FAD mutations does not interfere with beta-catenin/GSK3 beta/PS1 complex formation.

Design of Injection and Extraction Systems with Optimisation of Lattice and Layout for the CERN PS2 Synchrotron

CERN Document Server

Bartmann, W

2009-01-01

The CERN Proton Synchrotron PS2 is one of the foreseen accelerators for the LHC injector upgrade. This upgrade aims first at increasing the instantaneous luminosity of LHC and second at providing a reliable beam for the CERN accelerator complex. From this aspect, the main characteristics of the PS2 are high reliability for high intensity beams. The goal of this thesis was the design of the machine’s lattice and injection/extraction systems meeting the constraints coming mainly from the LHC beam type but also from beam requirements of experiments at PS2 and the SPS. In the design, the given energy range together with filling schemes for different beam types and RF cogging were first used to define the circumference of the machine. Estimates on the space requirements of injection/extraction systems were made in order to divide the total machine length between arc and long straight section. Existing tunnels for transfer lines together with the minimisation of the total transfer line length favoured a race trac...

The PS booster

CERN Multimedia

CERN PhotoLab

1972-01-01

The PS booster which accelerates protons from the linac at an energy of 50 MeV to an energy of 800 MeV before injecting them into the main magnet ring of the synchrotron. The booster consists of four superposed rings. In the photograph can be seen the input beam line from the linac and the output beam lines, where beams from the four booster levels have been combined into two beams before final recombination.

Delay-line cables for the fast bumpers in the PS.

CERN Multimedia

CERN PhotoLab

1976-01-01

For 'continuous transfer' to the SPS, the beam accelerated in the PS is shaved off over several turns, so as to form a continuous sequence of bunches several times the length of the PS circumference. Fast bumpers, powered in a 'staircase' way, displace the PS beam stepwise towards the ejection septum. Each step lasts 2.1 microsec and the cable drums in this picture contain some of the bumper delay-lines of altogether 10 km.

PS proton source

CERN Multimedia

1959-01-01

The first proton source used at CERN's Proton Synchrotron (PS) which started operation in 1959. This is CERN's oldest accelerator still functioning today (2018). It is part of the accelerator chain that supplies proton beams to the Large Hadron Collider. The source is a Thonemann type. In order to extract and accelerate the protons at high energy, a high frequency electrical field is used (140Mhz). The field is transmitted by a coil around a discharge tube in order to maintain the gas hydrogen in an ionised state. An electrical field pulse, in the order of 15kV, is then applied via an impulse transformer between anode and cathode of the discharge tube. The electrons and protons of the plasma formed in the ionised gas in the tube, are then separated. Currents in the order of 200mA during 100 microseconds have benn obtained with this type of source.

PS overcomes two serious magnet failures

CERN Multimedia

Maximilien Brice

2003-01-01

Two magnets (no.'s 6 and 19)and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. Pictured here are members of the PS team with the replacement no. 6 magnet. From left to right: In the back row, Frédéric Roussel (Transport DBS), Yves Bernard (Transport DBS), Luc Moreno (Cegelec), Thierry Battimanza (Transport DBS), Raymond Brown (AB/ABP), Thomas Zickler (AT/MEL); at the front, Steven Southern (AT/VAC), Thierry Gaidon (Brun & Sorensen), Philippe Vidales (Cegelec), Daniel Aubert (Cegelec), Jerome Cachet (Transport DBS), Jose Manual Gomes de Faria (AT/MEL), Eric Page (AT/VAC).

CERN Technical Training 2003: Learning for the LHC! : AXEL-2003  -  Introduction to Particle Accelerators

CERN Multimedia

2003-01-01

AXEL-2003 is a course given at CERN within the framework of the Technical Training Programme. The course will present an introduction to particle accelerators. Known in the past as the PS Complex Operation Course (or the "PS Shutdown Course"), and organised by the ex-PS division until last year, it is now organised as a joint venture between the AB division and Technical Training, and open to a wider CERN community. The AXEL-2003 course series is designed for technicians who are operating an accelerator, or whose work is closely linked to accelerators, but it is open to all people (technicians, engineers, physicists) interested in this field. The course does not require any prior knowledge on accelerators. However, some basic knowledge on trigonometry, matrices and differential equations, and some basic notions of magnetism would be an advantage. The course and the course supports will be in English, with questions and answers also in French. Lectures will be recorded and available online via the Web Lectu...

The PS overcomes two serious magnet failures

CERN Multimedia

2003-01-01

Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks.

Acceleration of polarized protons in the IHEP accelerator complex

International Nuclear Information System (INIS)

Anferov, V.A.; Ado, Yu.M.; Shoumkin, D.

1995-01-01

The paper considers possibility to accelerate polarized beam in the IHEP accelerator complex (including first stage of the UNK). The scheme of preserving beam polarization is described for all acceleration stages up to 400 GeV beam energy. Polarization and intensity of the polarized proton beam are estimated. The suggested scheme includes using two Siberian snakes in opposite straight sections of the UNK-1, where each snake consists of five dipole magnets. In the U-70 it is suggested to use one helical Siberian snake, which is turned on adiabatically at 10 GeV, and four pulsed quadrupoles. To incorporate the snake into the accelerator lattice it is proposed to make modification of one superperiod. This would make a 13 m long straight section. Spin depolarization in the Booster is avoided by decreasing the extraction energy to 0.9 GeV. Then no additional hardware is required in the Booster

The CERN accelerator complex

CERN Multimedia

Mobs, Esma Anais

2016-01-01

The LHC is the last ring (dark blue line) in a complex chain of particle accelerators. The smaller machines are used in a chain to help boost the particles to their final energies and provide beams to a whole set of smaller experiments, which also aim to uncover the mysteries of the Universe.

The CERN accelerator complex

CERN Multimedia

Christiane Lefèvre

2008-01-01

The LHC is the last ring (dark grey line) in a complex chain of particle accelerators. The smaller machines are used in a chain to help boost the particles to their final energies and provide beams to a whole set of smaller experiments, which also aim to uncover the mysteries of the Universe.

The CERN accelerator complex

CERN Multimedia

Haffner, Julie

2013-01-01

The LHC is the last ring (dark grey line) in a complex chain of particle accelerators. The smaller machines are used in a chain to help boost the particles to their final energies and provide beams to a whole set of smaller experiments, which also aim to uncover the mysteries of the Universe.

PS overcomes two serious magnet failures

CERN Multimedia

Maximilien Brice

2003-01-01

Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators´ spring start-up to two weeks. Here we see one of the replacement magnets (no. 19) being prepared.

PS overcomes two serious magnet failures

CERN Multimedia

Maximilien Brice

2003-01-01

Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. Here we see one of the replacement magnets (no. 6) being prepared.

Inauguration of POPS: the new power system of the PS

CERN Multimedia

Maximilien Brice

2010-01-01

Pictures 03 and 04 : The team from the Electrical Power Converters Group (TE/EPC) is joined by the Director of Accelerators, the heads of the BE, TE and FI departments, CERN managers and Converteam representatives in a group portrait in front of three of the containers that house the capacitor banks of the PS's new power supply system, POPS. Pictures 01, 06 and 07 : Magid-Michel Saikaly, energy and infrastructure director at Converteam, receives a prize from Steve Myers, Director of Accelerators at CERN, for the development and fabrication of the new electrical power system for the PS, called POPS.

The IFVE accelerating-storage complex (Present status)

International Nuclear Information System (INIS)

Balbekov, V.I.; Dmitrevski, Yu.P.; Kurnaev, O.V.

1979-01-01

A description of an accelerating-storage complex and the results of the development of its preliminary design are given. The first stage of the complex is a proton synchrotron with a standard electromagnet intended for storage and preliminary acceleration of protons to 400 GeV. Acceleration to 3 TeV will be provided by the second stage which is assumed to employ a superconducting magnet with 5 T. The existing 70 GeV synchrotron will be used as an injector. The magnetic structures of the first and second stages are identical. They include 180 FODO-type periods. Every period contains 12 dipoles and 2 quadrupole lenses. The accelerating devices should provide a total voltage amplitude of 12 MV or the superconducting ring. Three extraction modes are envisaged: a singleturn mode, a slow resonance extraction (during 30 s), and a fast resonance extraction of ten 1 ms pulses at 3 s intervals (6x10 13 protons per pulse). At present the preparation for testing 1 m long superconducting dipoles, HF systems, input and output devices is being completed. Measures aimed at suppressing the space charge effect are described. A possibility is investigated of obtaining 6 TeV by realizing proton-antiproton colliding beams in the complex by using the electron cooling method

Wall-Current-Monitor based Ghost and Satellite Bunch Detection in the CERN PS and the LHC Accelerators

CERN Document Server

Steinhagen, R J; Belleman, J; Bohl, T; Damerau, H

2012-01-01

While most LHC detectors and instrumentation systems are optimised for a nominal bunch spacing of 25 ns, the LHC RF cavities themselves operate at the 10th harmonic of the maximum bunch frequency. Due to the beam production scheme and transfers in the injector chain, part of the nominally ‘empty’ RF buckets may contain particles, referred to as ghost or satellite bunches. These populations must be accurately quantified for high-precision experiments, luminosity calibration and control of parasitic particle encounters at the four LHC interaction points. This contribution summarises the wall-current-monitor based ghost and satellite bunch measurements in CERN’s PS and LHC accelerators. Instrumentation set-up, post-processing and achieved performance are discussed.

1170-MW(t) HTGR-PS/C plant application study report: Geismar, Louisiana refinery/chemical complex application

International Nuclear Information System (INIS)

McMain, A.T. Jr.; Stanley, J.D.

1981-05-01

This report summarizes a study to apply an 1170-MW(t) high-temperature gas-cooled reactor - process steam/cogeneration (HTGR-PS/C) to an industrial complex at Geismar, Louisiana. This study compares the HTGR with coal and oil as process plant fuels. This study uses a previous broad energy alternative study by the Stone and Webster Corporation on refinery and chemical plant needs in the Gulf States Utilities service area. The HTGR-PS/C was developed by General Atomic (GA) specifically for industries which require both steam and electric energy. The GA 1170-MW(t) HTGR-PC/C design is particularly well suited to industrial applications and is expected to have excellent cost benefits over other energy sources

Accelerator complex for unstable beams at INS

International Nuclear Information System (INIS)

Tomizawa, M.; Arai, S.; Doi, M.; Katayama, T.; Niki, K.; Tokuda, N.; Yoshizawa, M.

1992-11-01

The construction of the prototype facility of the Exotic arena in the Japan Hadron Project (JHP) is started in 1992 at the Institute for Nuclear Study (INS), University of Tokyo. The purpose of this facility is to study the various technical problems of the Exotic arena, and to perform the experiment on nuclear and astrophysics with unstable nuclear beam. The unstable nuclei produced by bombarding a thick target with 40 MeV proton beam from the existing SF cyclotron are ionized in the ion sources, mass-analyzed by an ISOL, and transported to the accelerator complex. The accelerator complex consists of a split coaxial RFQ and an interdigital H type linac. The construction of accelerator will be completed in fiscal year 1994. The development of the SCRFQ and the IH linac which is suitable to the post-accelerator of the SCRFQ are reported. Charge stripper and the beam matching between the SCRFQ and the IH linac are explained. A buncher is necessary for the matching of longitudinal phase space between the SCRFQ and the IH linac. (K.I.)

(PS)2: protein structure prediction server version 3.0.

Science.gov (United States)

Huang, Tsun-Tsao; Hwang, Jenn-Kang; Chen, Chu-Huang; Chu, Chih-Sheng; Lee, Chi-Wen; Chen, Chih-Chieh

2015-07-01

Protein complexes are involved in many biological processes. Examining coupling between subunits of a complex would be useful to understand the molecular basis of protein function. Here, our updated (PS)(2) web server predicts the three-dimensional structures of protein complexes based on comparative modeling; furthermore, this server examines the coupling between subunits of the predicted complex by combining structural and evolutionary considerations. The predicted complex structure could be indicated and visualized by Java-based 3D graphics viewers and the structural and evolutionary profiles are shown and compared chain-by-chain. For each subunit, considerations with or without the packing contribution of other subunits cause the differences in similarities between structural and evolutionary profiles, and these differences imply which form, complex or monomeric, is preferred in the biological condition for the subunit. We believe that the (PS)(2) server would be a useful tool for biologists who are interested not only in the structures of protein complexes but also in the coupling between subunits of the complexes. The (PS)(2) is freely available at http://ps2v3.life.nctu.edu.tw/. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Common control system for the CERN accelerators

International Nuclear Information System (INIS)

Rausch, R.; Serre, Ch.

1992-01-01

The PS and SPS Accelerator Control Systems are becoming obsolete and need urgent rejuvenation. After a control users forum, where users expressed their needs, two main Working Groups were set up, consisting of Control and Equipment Specialists and experienced Machine Operators. One Working Group studied the architecture and the front-end processing and the other a common approach to the application software needed to run the CERN accelerator complex. The paper presents the technical conclusion of their work and the policy to implement it, taking into account the necessity to operate both machines without interruption of the Physics Program. (author)

Accelerating complex for basic researches in the nuclear physics

NARCIS (Netherlands)

Dovbnya, A.N.; Guk, I.S.; Kononenko, S.G.; Peev, F.A.; Tarasenko, A.S.; Botman, J.I.M.

2009-01-01

In 2003 in NSC KIPT was begun the work on development the project of accelerator, base facility IHEPNP NSC KIPT electron recirculator SALO. The accelerator will be disposed in target hall of accelerator LU 2000 complex. It is projected first of all as facility for basic researches in the field of

Complex of electrostatic accelerators for simulation and diagnostics of radiation damage

International Nuclear Information System (INIS)

Antuf'ev, Yu.P.; Belyaev, V.Kh.; Vergunov, A.D.

1983-01-01

The installation for simulation and diagnostics of radiation damage of materials is described. The installation consists of two electrostatic accelerators of vertical type for 5 MV and horizontal type for 800 kV. The accelerating complex ensures accelerated ion beam production in the independent operation regime as well as in the two beams target simultaneous irradiation regime, energy range of accelerated single-charged ions is 80 keV ... 5 MeV, homogeneity is better than +-0.05%. Oilless vacuum pumping out system is realized at the accelerating complex

Workstations as consoles for the CERN-PS complex, setting-up the environment

International Nuclear Information System (INIS)

Antonsanti, P.; Arruat, M.; Bouche, J.M.; Cons, L.; Deloose, Y.; Di Maio, F.

1992-01-01

Within the framework of the rejuvenation project of the CERN control systems, commercial workstations have to replace existing home-designed operator consoles. RISC-based workstations with UNIX, X-window TM and OSF/Motif TM have been introduced for the control of the PS complex. The first versions of general functionalities like synoptic display, program selection and control panels have been implemented and the first large scale application has been realized. This paper describes the different components of the workstation environment for the implementation of the applications. The focus is on the set of tools which have been used, developed or integrated, and on how we plan to make them evolve. (author)

A&T Sector Note on the PS transverse feedback

CERN Document Server

Coly, Marcel; Blas, Alfred; Sterbini, Guido; CERN. Geneva. ATS Department

2017-01-01

In a particle accelerator, several contributions can degrade the beam quality and particularly the beam transverse emittance. In this document we will describe a system used in the CERN Proton Synchrotron (PS) to cope with the injection steering errors and the transverse instabilities: the PS transverse feedback (PS TFB). As time progresses, this system is also being used for other purpose, to increase in a controlled way the beam transverse emittance and to excite the beam for the Multi-Turn-Extraction (MTE). In 2016, it has been successfully used on some operational beams to damp injection oscillations. This allowed to test the reliability of the system for its operational deployment. A piquet service is available in case of problem.

The SPS was the second cross-border accelerator

CERN Multimedia

2004-01-01

In the Golden Jubilee article in the issue 25/2004 (14 June) we should have written that the SPS was the first big cross-border accelerator. In fact, the SPS was not the first cross-border accelerator: that title goes to the PS Booster which became operational in 1972. The PS Booster passes beams to the PS and to the ISOLDE facility. We are sorry for the mistake and thank our vigilant readers.

The new heart of the PS is beating strongly

CERN Multimedia

Corinne Pralavorio

2011-01-01

The PS has resumed operation with a brand new electrical power system called POPS; this enormous system comprising power electronics and capacitors is crucial because if it broke down practically no particles would be able to circulate at CERN. As soon as it started, POPS passed all the tests with flying colours and is now pulsing at full power.   The new PS power system is made up of 6 containers, each with 60 tonnes of capacitors and 8 power converters. The date 11/02/11 will always be remembered with affection by the engineers in the Electrical Power Converters Group. At 11:11 in the morning (no joke), the first beams powered by the new system began to circulate in the PS. The cutely-named POPS (POwer for PS) took over from the old rotating machine that had been working since 1968. From now on it will be POPS that supplies the PS main magnets with the electrical pulses needed to accelerate the beams for the LHC and all CERN's other facilities. The system is crucial as the PS is one of the lyn...

The CERN PS/SL Controls Java Application Programming Interface

International Nuclear Information System (INIS)

I. Deloose; J. Cuperus; P. Charrue; F. DiMaio; K. Kostro; M. Vanden Eynden; W. Watson

1999-01-01

The PS/SL Convergence Project was launched in March 1998. Its objective is to deliver a common control as infrastructure for the CERN accelerators by year 2001. In the framework of this convergence activity, a project was launched to develop a Java Application Programming Interface (API) between programs written in the Java language and the PS and SL accelerator equipment. This Java API was specified and developed in collaboration with TJNAF. It is based on the Java CDEV [1] package that has been extended in order to end up with a CERN/TJNAF common product. It implements a detailed model composed of devices organized in named classes that provide a property-based interface. It supports data subscription and introspection facilities. The device model is presented and the capabilities of the API are described with syntax examples. The software architecture is also described

Accelerating molecular dynamic simulation on the cell processor and Playstation 3.

Science.gov (United States)

Luttmann, Edgar; Ensign, Daniel L; Vaidyanathan, Vishal; Houston, Mike; Rimon, Noam; Øland, Jeppe; Jayachandran, Guha; Friedrichs, Mark; Pande, Vijay S

2009-01-30

Implementation of molecular dynamics (MD) calculations on novel architectures will vastly increase its power to calculate the physical properties of complex systems. Herein, we detail algorithmic advances developed to accelerate MD simulations on the Cell processor, a commodity processor found in PlayStation 3 (PS3). In particular, we discuss issues regarding memory access versus computation and the types of calculations which are best suited for streaming processors such as the Cell, focusing on implicit solvation models. We conclude with a comparison of improved performance on the PS3's Cell processor over more traditional processors. (c) 2008 Wiley Periodicals, Inc.

SAFETY: STRICTER CONTROLS IN CONTROLLED AREAS IN THE PS

CERN Multimedia

G. Daems

2001-01-01

The PS accelerators will soon stop for several months. Work will take place in controlled areas in the PS and will involve many people who are not always aware of the risks associated with the work sites. To guarentee the safety of these workers, the following two measures will be applied: everyone working in a controlled zone - Linacs, PSB, and PS machines tunnels, and transfer lines - must wear, visibly, his CERN access card and his film badge. the CERN access card and the film badge will only be issued after following a basic safety course. Regular checks will be carried out during the shutdown. Anyone without these two items on their person will be obliged to leave the area immediately.

Neutron and photon dose assessment in Indus accelerator complex

International Nuclear Information System (INIS)

Verma, Dimple; Haridas Nair, G.; Bandopadhyay, Tapas; Tripathy, R.M.; Pal, Rupali; Bakshi, A.K.; Palani Selvam, T.; Datta, D.

2016-02-01

Indus Accelerator Complex (IAC) consists of 20 MeV Microtron, 450/550 MeV Booster, 450 MeV Indus-1 and 2.5 GeV Indus-2 storage rings. The radiation environment in Indus Accelerator Complex comprises of bremsstrahlung photons, electrons, positrons, photo neutrons and muons, out of which, bremsstrahlung photons are the major constituent of the prompt radiation. Major problem faced for on-line detection of neutrons is their severely pulsed nature. In the present study, measurement of neutron and photon dose rates in Indus Accelerator Complex was carried out using passive dosimeters such as CR-39 solid state nuclear track detector (SSNTD) and CaSO 4 :Dy Teflon disc, 6 LiF:Mg,Ti (TLD 600) and 7 LiF:Mg,Ti (TLD 700) based thermo luminescent (TL) detectors. The report describes the details of the measurement and discusses the results. (author)

The cellulose-binding activity of the PsB multiprotein complex is required for proper assembly of the spore coat and spore viability in Dictyostelium discoideum.

Science.gov (United States)

Srinivasan, S; Griffiths, K R; McGuire, V; Champion, A; Williams, K L; Alexander, S

2000-08-01

The terminal event of spore differentiation in the cellular slime mould Dictyostelium discoideum is the assembly of the spore coat, which surrounds the dormant amoeba and allows the organism to survive during extended periods of environmental stress. The spore coat is a polarized extracellular matrix composed of glycoproteins and cellulose. The process of spore coat formation begins by the regulated secretion of spore coat proteins from the prespore vesicles (PSVs). Four of the major spore coat proteins (SP96, PsB/SP85, SP70 and SP60) exist as a preassembled multiprotein complex within the PSVs. This complete complex has an endogenous cellulose-binding activity. Mutant strains lacking either the SP96 or SP70 proteins produce partial complexes that do not have cellulose-binding activity, while mutants lacking SP60 produce a partial complex that retains this activity. Using a combination of immunofluorescence microscopy and biochemical methods we now show that the lack of cellulose-binding activity in the SP96 and SP70 mutants results in abnormally assembled spore coats and spores with greatly reduced viability. In contrast, the SP60 mutant, in which the PsB complex retains its cellulose-binding activity, produces spores with apparently unaltered structure and viability. Thus, it is the loss of the cellulose-binding activity of the PsB complex, rather than the mere loss of individual spore coat proteins, that results in compromised spore coat structure. These results support the idea that the cellulose-binding activity associated with the complete PsB complex plays an active role in the assembly of the spore coat.

On the polarized beam acceleration in medium energy synchrotrons

International Nuclear Information System (INIS)

Lee, S.Y.

1992-01-01

This lecture note reviews physics of spin motion in a synchrotron, spin depolarization mechanisms of spin resonances, and methods of overcoming the spin resonances during acceleration. Techniques used in accelerating polarized ions in the low/medium energy synchrotrons, such as the ZGS, the AGS, SATURNE, and the KEK PS and PS Booster are discussed. Problems related to polarized proton acceleration with snakes or partial snake are also examined

On the polarized beam acceleration in medium energy synchrotrons

Energy Technology Data Exchange (ETDEWEB)

Lee, S.Y.

1992-12-31

This lecture note reviews physics of spin motion in a synchrotron, spin depolarization mechanisms of spin resonances, and methods of overcoming the spin resonances during acceleration. Techniques used in accelerating polarized ions in the low/medium energy synchrotrons, such as the ZGS, the AGS, SATURNE, and the KEK PS and PS Booster are discussed. Problems related to polarized proton acceleration with snakes or partial snake are also examined.

On the crystallization behavior of syndiotactic-b-atactic polystyrene stereodiblock copolymers, atactic/syndiotactic polystyrene blends, and aPS/sPS blends modified with sPS-b-aPS

Energy Technology Data Exchange (ETDEWEB)

Annunziata, Liana, E-mail: liana.annunziatta@univ-rennes1.fr [Organométalliques et Catalyse, UMR 6226 Sciences Chimiques CNRS, Université de Rennes 1, Campus de Beaulieu, F-35042 Rennes Cedex (France); Monasse, Bernard, E-mail: bernard.monasse@mines-paristech.fr [Mines-ParisTech, CEMEF, Centre de Mise en Forme des Matériaux, UMR CNRS 7635, Sophia Antipolis (France); Rizzo, Paola; Guerra, Gaetano [Dipartimento di Chimica e Biologia, Università degli studi di Salerno, Via Ponte don Melillo, I-84084 Fisciano, SA (Italy); Duc, Michel [Total Petrochemicals Research Feluy, Zone Industrielle Feluy C, B-7181 Seneffe (Belgium); Carpentier, Jean-François, E-mail: jean-francois.carpentier@univ-rennes1.fr [Organométalliques et Catalyse, UMR 6226 Sciences Chimiques CNRS, Université de Rennes 1, Campus de Beaulieu, F-35042 Rennes Cedex (France)

2013-09-16

Crystallization and morphological features of syndiotactic-b-atactic polystyrene stereodiblock copolymers (sPS-b-aPS), atactic/syndiotactic polystyrene blends (aPS/sPS), and aPS/sPS blends modified with sPS-b-aPS, with different compositions in aPS and sPS, have been investigated using differential scanning calorimetry (DSC), polarized light optical microscopy (POM) and wide angle X-ray diffraction (WAXRD) techniques. For comparative purposes, the properties of parent pristine sPS samples were also studied. WAXRD analyses revealed for all the samples, independently from their composition (aPS/sPS ratio) and structure (blends, block copolymers, blends modified with block copolymers), the same polymorphic β form of sPS. The molecular weight of aPS and sPS showed opposite effects on the crystallization of 50:50 aPS/sPS blends: the lower the molecular weight of aPS, the slower the crystallization while the lower the molecular weight of sPS, the faster the crystallization. DSC studies performed under both isothermal and non-isothermal conditions, independently confirmed by POM studies, led to a clear trend for the crystallization rate at a given sPS/aPS ratio (ca. 50:50 and 20:80): sPS homopolymers > sPS-b-aPS block copolymers ∼sPS/aPS blends modified with sPS-b-aPS copolymers > sPS/aPS blends. Interestingly, sPS-b-aPS block copolymers not only crystallized faster than blends, but also affected positively the crystallization behavior of blends. At 50:50 sPS/aPS ratio, blends (Blend-2), block copolymers (Cop-1) and blends modified with block copolymers (Blend-2-mod) crystallized via spherulitic crystalline growth controlled by an interfacial process. In all cases, an instantaneous nucleation was observed. The density of nuclei in block copolymers (160,000−190,000 nuclei mm{sup −3}) was always higher than that in blends and modified blends (30,000−60,000 nuclei mm{sup −3}), even for quite different sPS/aPS ratio. At 20:80 sPS/aPS ratio, the block copolymers

Beyond metric gravity: Progress on PS-200

International Nuclear Information System (INIS)

Goldman, T.; Brown, R.E.; Camp, J.B.; Darling, T.; Dyer, P.; Holzscheiter, M.H.; Hughes, R.J.; Jarmie, N.; King, N.S.P.; Lizon, D.C.; Nieto, M.M.; Schauer, M.M.M.; Schecker, J.A.; Cornford, S.; Hosea, K.; Kenefick, R.A.; Hoibraaten, S.; Midzor, M.M.; Parry, S.P.; Ristenen, R.A.; Witteborn, F.C.

1993-01-01

The reconciliation of quantum mechanics and gravity on varying distance scales requires changes to General Relativity that may be testable implications. We briefly review the status of tests with matter of the inverse square law and the principle of equivalence, then report on progress on the drift-tube measurement section of PS- 200, the experiment to measure the gravitational acceleration of antiprotons

Complex calculation and improvement of beam shaping and accelerating system of the ''Sokol'' small-size electrostatic accelerator

International Nuclear Information System (INIS)

Simonenko, A.V.; Pistryak, V.M.; Zats, A.V.; Levchenko, Yu.Z.; Kuz'menko, V.V.

1987-01-01

Features of charged particle accelerated beam shaping in the electrostatic part of the ''Sokol'' small-size accelerator are considered in complex taking into account the electrode real geometry. Effect of the extracting, accelerating electorde potential and accelerator total voltage on beam behaviour is investigated. A modified variation of the beam shaping system, allowing to decrease 2 times the required interval of accelerating electrode potential adjustment and to decrease the beam size in the starting acceleration region, is presented. It permits to simplify the construction and to improve accelerator operation. Comparison of experimental and calculational data on the beam in the improved accelerator variation is carried out. Effect of peripheral parts of accelerating tube electrodes on the beam is investigated

KEK (High Energy Accelerator Research Organization) annual report, 2005

International Nuclear Information System (INIS)

2006-01-01

This report summarizes research activities of KEK (High Energy Accelerator Research Organization) in the fiscal year 2005. Two years have passed since the KEK was reorganized as an inter-university research institute corporation, and KEK continue to facilitate a wide range of research programs based on high-energy accelerators for users from universities. KEK consists of two research institutes, the Institute of Particle and Nuclear Studies (IPNS) and the Institute of Materials Science (IMSS); and two laboratories, the Accelerator Laboratory and the Applied Research Laboratory. KEK has been operating four major accelerator facilities in Tsukuba: the 12 GeV Proton Synchrotron (PS), the KEK B-factory (KEKB), the Photon Factory (PF), and the Electron/Positron Injector Linac. We are now engaged in the construction of the Japan Proton Accelerator Research Complex (J-PARC) in Tokai in cooperation with the Japan Atomic Energy Agency (JAEA). The J-PARC Center was established in February 2006 to take full responsibility for the operation of J-PARC. With the progress of construction, the PS ceased operation at the end of March 2006 after a history of 26 years. The task of KEK is to play a key role in the fields of elementary particle, nuclei, materials and life science as one of leading research facilities of the world. The fiscal year 2005 activities of both KEK employees and visiting researchers yielded excellent outcomes in these research fields. (J.P.N.)

First accelerator-based physics of 2014

CERN Multimedia

Katarina Anthony

2014-01-01

Experiments in the East Area received their first beams from the PS this week. Theirs is CERN's first accelerator-based physics since LS1 began last year.   For the East Area, the PS performs a so-called slow extraction, where beam is extracted during many revolution periods (the time it take for particles to go around the PS, ~2.1 μs). The yellow line shows the circulating beam current in the PS, decreasing slowly during the slow extraction, which lasts 350 ms. The green line is the measured proton intensity in the transfer line toward the East Area target. Although LHC physics is still far away, we can now confirm that the injectors are producing physics! In the East Area - the experimental area behind the PS - the T9 and T10 beam lines are providing beams for physics. These beam lines serve experiments such as AIDA - which looks at new detector solutions for future accelerators - and the ALICE Inner Tracking System - which tests components for the ALICE experiment. &qu...

Measuring target for the PS Booster

CERN Multimedia

1971-01-01

The measuring target for the PS Booster (originally 800 MeV, now 1.4 GeV). It measures the size of the beam by destroying all particles with amplitudes greater than the size of the fork, the position and width of which are adjustable. The plunging time is only 20 ms and the acceleration at the tip of the fork reaches 90 g. The servo-controlled linear motor is shown detached from the mechanism. See also 7602008.

GPU Accelerated Surgical Simulators for Complex Morhpology

DEFF Research Database (Denmark)

Mosegaard, Jesper; Sørensen, Thomas Sangild

2005-01-01

a springmass system in order to simulate a complex organ such as the heart. Computations are accelerated by taking advantage of modern graphics processing units (GPUs). Two GPU implementations are presented. They vary in their generality of spring connections and in the speedup factor they achieve...

Theoretical considerations regarding the existence of PsO and PsS+

International Nuclear Information System (INIS)

Farazdel, A.; Cade, P.E.

1977-01-01

It has been proposed from experimental studies and in analogy with hydrogen compounds that PsO may be an entity of some importance, or an intermediate, in the reaction of positronium, Ps, with aqueous oxyacid species such as H 2 PO 4 - , HSO 4 - , ClO 4 - , and NO 3 - . This communication explores the stability of PsO and PsS, or [O - :e + ] and [S - :e + ], respectively, relative to dissociation into Ps and O( 3 P) or S( 3 P) on the basis of restricted Hartree-Fock calculations for the PsO and PsS systems and certain correlation correction arguments. A reasonable lower estimate of the dissociation energy to Y+Ps of >-0.47 eV for PsO and >0.70 eV for PsS is obtained. It is suggested that a modest correlation correction to the positron affinity (PA) of O - would very probably lead to a bound state system for PsO. (Auth.)

The CERN Antiproton Collider Programme Accelerators and Accumulation Rings

CERN Document Server

Koziol, Heribert

2004-01-01

One of CERN's most daring and successful undertakings was the quest for the intermediate bosons, W and Z. In this paper, we describe the accelerator part of the venture which relied on a number of innovations: an extension of the budding method of stochastic cooling by many orders of magnitude; the construction of the Antiproton Accumulator, depending on several novel accelerator methods and technologies; major modifications to the 26 GeV PS Complex; and the radical conversion of the 300 GeV SPS, which just had started up as an accelerator, to a protonâ€"antiproton collider. The SPS Collider had to master the beamâ€"beam effect far beyond limits reached ever before and had to function in a tight symbiosis with the huge detectors UA1 and UA2.

Preparations for Upgrading the RF Systems of the PS Booster

CERN Document Server

Albright, Simon; Shaposhnikova, Elena

2016-01-01

The accelerators of the LHC injector chain need to be upgraded to provide the HL-LHC beams. The PS Booster, the first synchrotron in the LHC injection chain, uses three different RF systems (first, second and up to tenth harmonic) in each of its four rings. As part of the LHC Injector Upgrade the current ferrite RF systems will be replaced with broadband Finemet cavities, increasing the flexibility of the RF system. A Finemet test cavity has been installed in Ring 4 to investigate its effect on machine performance, especially beam stability, during extensive experimental studies. Due to large space charge impedance Landau damping is lost through most of the cycle in single harmonic operation, but is recovered when using the second harmonic and controlled longitudinal emittance blow-up. This paper compares beam parameters during acceleration with and without the Finemet test cavity. Comparisons were made using beam measurements and simulations with the BLonD code based on a full PS Booster impedance model. Thi...

Observations of the Coronal Mass Ejection with a Complex Acceleration Profile

Science.gov (United States)

Reva, A. A.; Kirichenko, A. S.; Ulyanov, A. S.; Kuzin, S. V.

2017-12-01

We study the coronal mass ejection (CME) with a complex acceleration profile. The event occurred on 2009 April 23. It had an impulsive acceleration phase, an impulsive deceleration phase, and a second impulsive acceleration phase. During its evolution, the CME showed signatures of different acceleration mechanisms: kink instability, prominence drainage, flare reconnection, and a CME–CME collision. The special feature of the observations is the usage of the TESIS EUV telescope. The instrument could image the solar corona in the Fe 171 Å line up to a distance of 2 {R}ȯ from the center of the Sun. This allows us to trace the CME up to the LASCO/C2 field of view without losing the CME from sight. The onset of the CME was caused by kink instability. The mass drainage occurred after the kink instability. The mass drainage played only an auxiliary role: it decreased the CME mass, which helped to accelerate the CME. The first impulsive acceleration phase was caused by the flare reconnection. We observed the two-ribbon flare and an increase of the soft X-ray flux during the first impulsive acceleration phase. The impulsive deceleration and the second impulsive acceleration phases were caused by the CME–CME collision. The studied event shows that CMEs are complex phenomena that cannot be explained with only one acceleration mechanism. We should seek a combination of different mechanisms that accelerate CMEs at different stages of their evolution.

The first acceleration test of polarized protons in KEK PS

International Nuclear Information System (INIS)

Hiramatsu, Shigenori; Sato, Hikaru; Toyama, Takeshi

1984-03-01

The outline of the polarized proton acceleration project at KEK and the results of the first acceleration test are described. Depolarization in the 500 MeV booster synchrotron was investigated as the first step of this program. The beam polarization was measured in the 20 MeV beam transport line from the linac to the booster and in the main ring at the injection energy. About 40 % of the linac beam polarization was kept in the main ring. This acceleration test encouraged us to proceed with this program. (author)

Determination of Beam Intensity and Position in a Particle Accelerator

CERN Document Server

Kasprowicz, Grzegorz; Raich, Uli

2011-10-04

A subject of the thesis is conception, design, implementation, tests and deployment of new position measurement system of particle bunch in the CERN PS circular accelerator. The system is based on novel algorithms of particle position determination. The Proton Synchrotron accelerator (PS), installed at CERN†, although commissioned in 1959, still plays a central role in the production of beams for the Antiproton Decelerator, Super Proton Synchrotron, various experimental areas and for the Large Hadron Collider (LHC)‡. The PS produces beams of different types of particles, mainly protons, but also various species of ions. Almost all these particle beams pass through the PS. The quality of the beams delivered to the LHC has a direct impact on the effective luminosity, and therefore the performance of the instrumentation of the PS is of great importance. The old trajectory and orbit measurement system of the PS is dated back to 1988 and no longer fulfilled present day requirements. It used 40 beam posi...

Determination of beam intensity and position in a particle accelerator

CERN Document Server

Kasprowicz, G

2011-01-01

A subject of the thesis is conception, design, implementation, tests and deployment of new position measurement system of particle bunch in the CERN PS circular accelerator. The system is based on novel algorithms of particle position determination. The Proton Synchrotron accelerator (PS), installed at CERN, although commissioned in 1959, still plays a central role in the production of beams for the Antiproton Decelerator, Super Proton Synchrotron, various experimental areas and for the Large Hadron Collider (LHC). The PS produces beams of different types of particles, mainly protons, but also various species of ions. Almost all these particle beams pass through the PS. The quality of the beams delivered to the LHC has a direct impact on the effective luminosity, and therefore the performance of the instrumentation of the PS is of great importance. The old trajectory and orbit measurement system of the PS is dated back to 1988 and no longer fulfilled present day requirements. It used 40 beam position monitors...

Plans for the Future of Proton Accelerators at CERN

CERN Document Server

Garoby, R; High Intensity Frontier Workshop (HIF04)

2005-01-01

The Large Hadron Collider, presently in construction at CERN, will be filled through a set of high performance proton accelerators providing the high brightness beam needed to reach the foreseen luminosity. Although this difficult project has top priority and uses most of the CERN resources, it is nevertheless time investigating improvements of the proton accelerator complex for physical cases beyond the LHC expectations. The needs of multiple physics communities have to be taken into account, as well as the necessity of consolidating the installations while keeping high reliability. This paper starts from the analysis and proposals made by the “High Intensity Proton” (HIP) working group [1, 2] to improve the performances of the PS and the SPS complex and better match the users requests in a staged scenario at short and medium term, and complement it, addressing the main possibilities beyond that horizon.

The high energy accelerator program in Japan

International Nuclear Information System (INIS)

Ozaki, S.

1987-01-01

The author observes that in order to survey the intentions of Japanese high energy physicists and to make a recommendation to the High Energy Committee on future plans for high energy physics in Japan, including accelerators after TRISTAN, international collaboration projects and non-accelerator physics, a subcommittee of fifteen members is formed. The committee recommendation reads: A) For a new energy frontier, 1. Immediate initiation of R/D efforts for an e/sup +/e/sup -/ linear collider of TeV class, constructs a possible home-based facility, 2. Promotes international collaborative experiments using the SSC for the hadron sector, B) As projects of immediate concern: 1. The energy of the TRISTAN main ring increases further makes a possible low energy, high luminosity e/sup +/e/sup -/ collider operation in the TRISTAN complex, 2. The intensity of the 12 GeV PS at KEK increases, 3. Experiments in non-accelerator particle physics are promoted. In this contribution, the current status of the TRISTAN project and some of the R/D program on accelerator technology are reported

Improvement Plans of Fermilab’s Proton Accelerator Complex

Science.gov (United States)

Shiltsev, Vladimir

2017-09-01

The flagship of Fermilab’s long term research program is the Deep Underground Neutrino Experiment (DUNE), located Sanford Underground Research Facility (SURF) in Lead, South Dakota, which will study neutrino oscillations with a baseline of 1300 km. The neutrinos will be produced in the Long Baseline Neutrino Facility (LBNF), a proposed new beam line from Fermilab’s Main Injector. The physics goals of the DUNE require a proton beam with a power of some 2.4 MW at 120 GeV, which is roughly four times the current maximum power. Here I discuss current performance of the Fermilab proton accelerator complex, our plans for construction of the SRF proton linac as key part of the Proton Improvement Plan-II (PIP-II), outline the main challenges toward multi-MW beam power operation of the Fermilab accelerator complex and the staged plan to achieve the required performance over the next 15 years.

Radiation safety aspects at Indus accelerator complex

International Nuclear Information System (INIS)

Marathe, R.G.

2011-01-01

Indus Accelerator Complex at Raja Ramanna Center for Advanced Technology houses two synchrotron radiation sources Indus-1 and Indus-2 that are being operated round-the-clock to cater to the needs of the research community. Indus-1 is a 450 MeV electron storage ring and Indus-2 is presently being operated with electrons stored at 2 GeV. Bremsstrahlung radiation and photo-neutrons form the major radiation environment in Indus Accelerator Complex. They are produced due to loss of electron-beam occurring at different stages of operation of various accelerators located in the complex. The synchrotron radiation (SR) also contributes as a potential hazard. In order to ensure safety of synchrotron radiation users and operation and maintenance staff working in the complex from this radiation, an elaborate radiation safety system is in place. The system comprises a Personnel Protection System (PPS) and a Radiation Monitoring System (RMS). The PPS includes zoning, radiation shielding, door interlocks, a search and scram system and machine operation trip-interlocks. The RMS consists of area radiation monitors and beam loss monitors, whose data is available online in the Indus control room. Historical data of radiation levels is also available for data analysis. Synchrotron radiation beamlines at Indus-2 are handled in a special manner owing to the possibility of exposure to synchrotron radiation. Shielding hutches with SR monitors are installed at each beamline of Indus-2. Health Physics Unit also carries out regular radiological surveillance for photons and neutrons during various modes of operation and data is logged shift wise. The operation staff is appropriately trained and qualified as per the recommendations of Atomic Energy Regulatory Board (AERB). Safety training is also imparted to the beamline users. Safe operation procedures and operation checklists are being followed strictly. A radiation instrument calibration facility is also being set-up at RRCAT. The radiation

Winter therapy for the accelerators

CERN Multimedia

Corinne Pralavorio

2016-01-01

Hundreds of people are hard at work during the year-end technical stop as all the accelerators are undergoing maintenance, renovation and upgrade operations in parallel.   The new beam absorber on its way to Point 2 before being lowered into the LHC tunnel for installation. The accelerator teams didn’t waste any time before starting their annual winter rejuvenation programme over the winter. At the end of November, as the LHC ion run was beginning, work got under way on the PS Booster, where operation had already stopped. On 14 December, once the whole complex had been shut down, the technical teams turned their attention to the other injectors and the LHC. The year-end technical stop (YETS) provides an opportunity to carry out maintenance work on equipment and repair any damage as well as to upgrade the machines for the upcoming runs. Numerous work projects are carried out simultaneously, so good coordination is crucial. Marzia Bernardini's team in the Enginee...

A provisional study of ADS within Turkic Accelerator Complex project

International Nuclear Information System (INIS)

Bilgin, P.S.; Caliskan, A.; Sultansoy, S.

2011-01-01

The Turkic Accelerator Complex (TAC) project has been developed with the support of the Turkish State Planning Organization by the collaboration of 10 Turkish universities. The complex is planned to have four main facilities, namely: SASE FEL Facility based on 1 GeV Electron Linac, Third Generation Synchrotron Radiation Facility (SR) based on 3.56 GeV Positron Synchrotron, Super-Charm factory (√s = 3.77 GeV) by colliding the electron beam coming from the linac with an energy of 1 GeV and positron beam coming through the positron ring with an energy of 3.56 GeV, GeV scale proton accelerator. Later has two-fold goal: Neutron Spallation Source (NSS) and ADS. The proton accelerator construction will have 3 MeV, 100 MeV, and 1 GeV phases. The technical design report is planned to be finished in 2013. Since Turkey has essential Thorium reserves the ADS becomes very attractive for our country as emerging energy technology. (author)

Asymmetric PS-block-(PS-co-PB)-block-PS block copolymers: morphology formation and deformation behaviour

International Nuclear Information System (INIS)

Adhikari, Rameshwar; Huy, Trinh An; Buschnakowski, Matthias; Michler, Goerg H; Knoll, Konrad

2004-01-01

Morphology formation and deformation behaviour of asymmetric styrene/butadiene triblock copolymers (total polystyrene (PS) content ∼70%) consisting of PS outer blocks held apart by a styrene-co-butadiene random copolymer block (PS-co-PB) each were investigated. The techniques used were differential scanning calorimetry, transmission electron microscopy, uniaxial tensile testing and Fourier-transform infrared spectroscopy. A significant shift of the phase behaviour relative to that of a neat symmetric triblock copolymer was observed, which can be attributed to the asymmetric architecture and the presence of PS-co-PB as a soft block. The mechanical properties and the microdeformation phenomena were mainly controlled by the nature of their solid-state morphology. Independent of morphology type, the soft phase was found to deform to a significantly higher degree of orientation when compared with the hard phase

Synthesis of NiPS3 and CoPS and its hydrogen storage capacity

International Nuclear Information System (INIS)

Ismail, N.; Madian, M.; El-Meligi, A.A.

2014-01-01

Highlights: • Preparation of NiPS 3 and CoPS using solid state reaction. • Characterization of compounds using XRD, TEM, SEM and IR. • Measuring the compounds thermal stability. • Estimation of the hydrogen storage capacity. -- Abstract: Prepared CoPS and NiPS 3 are studied as new materials for hydrogen energy storage. Single phase of CoPS and NiPS 3 were grown separately in evacuated silicatube via solid state reaction at 650 °C with controlled heating rate 1 °C/min. X-ray diffraction patterns confirm the formation of the desired compounds. Both CoPS and NiPS 3 exhibited high thermal stability up to 700 °C and 630 °C, respectively. The morphology of the prepared samples was investigated using scanning electron microscopy and folded sheets appeared in the transmission electron microscopy. The samples were exposed to 20 bar applied hydrogen pressure at 80 K. Both compounds appear to have feasible hydrogen storage capacity. CoPS was capable to adsorb 1.7 wt% while NiPS 3 storage capacity reached 1.2 wt%

The SPS as accelerator of Pb$^{82+}$ ions

CERN Document Server

Faugier, A; Bailey, R; Blanchard, R R; Bohl, T; Brouzet, E; Burkhardt, H; Collier, Paul; Cornelis, Karel; de Rijk, G; Ferioli, F; Hilaire, A; Lamont, M; Linnecar, Trevor Paul R; Jonker, M; Niquille, C; Roy, G; Schmickler, Hermann

1996-01-01

In 1994 the CERN SPS was used for the first time to accelerate fully stripped ions of the Pb208 isotope from the equivalent proton momentum of 13 GeV/c to 400 GeV/c. In the CERN PS, which was used as injector, the lead was accelerated as Pb53+ ions and then fully stripped in the transfer line from PS to SPS. The radio frequency swing which is needed in order to keep the synchronism during acceleration is too big to have the SPS cavities deliver enough voltage for all frequencies. For that reason a new technique of fixed frequency acceleration was used. With this technique up to 70% of the injected beam could be captured and accelerated up to the extraction energy, the equivalent of 2.2 1010 charges. The beam was extracted over a 5 sec. long spill and was then delivered to different experiments at the same time.

The PrPS4 type structure and a filled variant: the compounds TbPS4 and LiEuPS4

International Nuclear Information System (INIS)

Joergens, S.; Alili, L.; Mewis, A.

2005-01-01

Colourless single crystals of TbPS 4 (a = 10.696(2), c = 19.053(4) Aa) were obtained by reaction of the elements (750 C; 30 h). The compound crystallizes with the PrPS 4 type structure (I4 1 /acd; Z = 16). The structure consists of isolated PS 4 tetrahedra each surrounded by four Tb 3+ cations. Both crystallographically different Tb 3+ cations are coordinated by eight sulfur atoms which are part of four PS 4 tetrahedra. Orange single crystals of LiEuPS 4 (a = 11.498(2), c = 19.882(4) Aa) were prepared by reaction of Eu and P with Li 2 S 4 (700 C; 20 h). The crystal structure corresponds to the PrPS 4 type, in which tubes running along [001] are occupied by Li atoms, which are surrounded by four S atoms in strongly distorted tetrahedra. LiS 4 and PS 4 tetrahedra are connected via common edges into alternating chains. (orig.)

The BNL Accelerator Test Facility and experimental program

International Nuclear Information System (INIS)

Ben-Zvi, I.; State Univ. of New York, Stony Brook, NY

1992-01-01

The Accelerator Test Facility (ATF) at BNL is a users' facility for experiments in Accelerator and Beam Physics. The ATF provides high brightness electron beams and high-power laser pulses synchronized to the electron beam, suitable for studies of new methods of high-gradient acceleration and state-of-the-art Free-Electron Lasers. The electrons are produced by a laser photocathode rf gun and accelerated to 50 MeV by two traveling wave accelerator sections. The lasers include a 10 mJ, 10 ps ND:YAG laser and a 500 mJ, 10 to 100 ps C0 2 laser. A number of users from National Laboratories, universities and industry take part in experiments at the ATF. The experimental program includes various laser acceleration schemes, Free-Electron Laser experiments and a program on the development of high-brightness electron beams. The ATF's experimental program commenced in early 1991 at an energy of about 4 MeV. The full program, with 50 MeV and the high-power laser will begin operation this year

The BNL Accelerator Test Facility and experimental program

International Nuclear Information System (INIS)

Ben-Zvi, I.; State Univ. of New York, Stony Brook, NY

1991-01-01

The Accelerator Test Facility (ATF) at BNL is a users' facility for experiments in Accelerator and Beam Physics. The ATF provides high brightness electron beams and high power laser pulses synchronized to the electron beam, suitable for studies of new methods of high gradient acceleration and state of the art free electron lasers. The electrons are produced by a laser photocathode rf gun and accelerated to 50 to 100 MeV by two traveling wave accelerator sections. The lasers include a 10 mJ, 10 ps Nd:YAG laser and a 100 mJ, 10 ps CO 2 laser. A number of users from National Laboratories, universities and industry take part in experiments at the ATF. The experimental program includes various acceleration schemes, Free-Electron Laser experiments and a program on the development of high brightness electron beams. The AFT's experimental program commenced in early 1991 at an energy of about 4 MeV. The full program, with 50 MeV and the High power laser will begin operation this year. 28 refs., 4 figs

Early enriched environment exposure protects spatial memory and accelerates amyloid plaque formation in APP(Swe/PS1(L166P mice.

Directory of Open Access Journals (Sweden)

Francesca Montarolo

Full Text Available Enriched environment exposure improves several aspects of cognitive performance in Alzheimer's disease patients and in animal models and, although the role of amyloid plaques is questionable, several studies also assessed their response to enriched environment, with contrasting results. Here we report that rearing APP(Swe/PS1(L166P mice in an enriched environment since birth rescued the spatial memory impairment otherwise present at 6 months of age. At the same time, the exposure to the enriched environment caused a transient acceleration of plaque formation, while there was no effect on intracellular staining with the 6E10 antibody, which recognizes β-amyloid, full length amyloid precursor protein and its C-terminal fragments. The anticipation of plaque formation required exposure during early development, suggesting an action within critical periods for circuits formation. On the other hand, chronic neuronal activity suppression by tetrodotoxin decreased the number of plaques without affecting intracellular amyloid. These results indicate that enriched environment exposure since early life has a protective effect on cognitive deterioration although transiently accelerates amyloid deposition. In addition, the effects of the enriched environment might be due to increased neuronal activity, because plaques were reduced by suppression of electrical signaling by tetrodotoxin.

Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice

DEFF Research Database (Denmark)

Laursen, Bettina; Mørk, Arne; Plath, Niels

2013-01-01

mice was not due to a more extensive cholinergic degeneration since the reduction in choline acetyltransferase activity was similar following SAP treatment in APP/PS1 mice and Wt. Interestingly, plaque load was significantly increased in SAP treated APP/PS1 mice relative to sham lesioned APP/PS1 mice....... Additionally, APP/PS1 mice treated with SAP showed a tendency towards an increased level of soluble and insoluble Aß1-40 and Aß1-42 measured in brain tissue homogenate. Our results suggest that the combination of cholinergic degeneration and Aß overexpression in the APP/PS1 mouse model results in cognitive...... decline and accelerated plaque burden. SAP treated APP/PS1 mice might thus constitute an improved model of Alzheimer's disease-like neuropathology and cognitive deficits compared to the conventional APP/PS1 model without selective removal of basal forebrain cholinergic neurons....

Prevalence of antibodies to prothrombin in solid phase (aPT) and to phosphatidylserine-prothrombin complex (aPS/PT) in patients with and without lupus anticoagulant.

Science.gov (United States)

Bertolaccini, Maria Laura; Sciascia, Savino; Murru, Veronica; Garcia-Fernandez, Cesar; Sanna, Giovanni; Khamashta, Munther A

2013-02-01

Antibodies to prothrombin in solid phase (aPT) and those to phosphatidiyserine-prothrombin complex (aPS/PT) have been suggested to strongly correlate with the presence of lupus anticoagulant (LA). As their clinical diagnostic value and true relationship with the LA remains elusive, we designed this study to evaluate the prevalence and significance of aPT and aPS/PT in a large cohort of patients with and without LA. Samples from 257 patients were included. aPT and aPS/PT were tested by ELISA. LA was tested as per the current criteria from the ISTH Subcommittee on LA-Phospholipid-dependent antibodies. aPS/PT and aPT were found in 51% and 32% of LA-positive (LA+ve) patients and in 22% and 28% of LA-negative (LA-ve) patients, respectively. Thrombosis, particularly venous thrombosis was associated with IgG aPT in the LA+ve group (p=0.0006) and in the LA-ve group (p=0.017). Antibodies to phosphatidylserine-prothrombin, either IgG and IgM were associated with thrombosis in general (p=0.0003) in particularly with venous thrombosis in the LA+ve group (paPS/PT were independent risk factors for thrombosis and pregnancy loss. In conclusion, aPS/PT, but not aPT, are more frequently found in patients with LA. Their association with thrombosis seems to be independent of the presence of LA.

A complex molecular interplay of auxin and ethylene signaling pathways is involved in Arabidopsis growth promotion by Burkholderia phytofirmans PsJN

Directory of Open Access Journals (Sweden)

María Josefina Poupin

2016-04-01

Full Text Available Modulation of phytohormones homeostasis is one of the proposed mechanisms to explain plant growth promotion induced by beneficial rhizobacteria (PGPR. However, there is still limited knowledge about the molecular signals and pathways underlying these beneficial interactions. Even less is known concerning the interplay between phytohormones in plants inoculated with PGPR. Auxin and ethylene are crucial hormones in the control of plant growth and development, and recent studies report an important and complex crosstalk between them in the regulation of different plant developmental processes. The objective of this work was to study the role of both hormones in the growth promotion of Arabidopsis thaliana plants induced by the well-known PGPR Burkholderia phytofirmans PsJN. For this, the spatiotemporal expression patterns of several genes related to auxin biosynthesis, perception and response and ethylene biosynthesis were studied, finding that most of these genes showed specific transcriptional regulations after inoculation in roots and shoots. PsJN-growth promotion was not observed in Arabidopsis mutants with an impaired ethylene (ein2-1 or auxin (axr1-5 signaling. Even, PsJN did not promote growth in an ethylene overproducer (eto2, indicating that a fine regulation of both hormones signaling and homeostasis is necessary to induce growth of the aerial and root tissues. Auxin polar transport is also involved in growth promotion, since PsJN did not promote primary root growth in the pin2 mutant or under chemical inhibition of transport in wild type plants. Finally, a key role for ethylene biosynthesis was found in the PsJN-mediated increase in root hair number. These results not only give new insights of PGPR regulation of plant growth but also are also useful to understand key aspects of Arabidopsis growth control.

Wandering accelerators throughout my life (4)

International Nuclear Information System (INIS)

Nakai, Kozi

2010-01-01

My effort in the last stage of wandering about accelerator was to bridge the gap between nuclear and high-energy physics at the KEK-PS. Since the TRISTAN construction started, the KEK-PS has been opened to nuclear physics users. Among various possibilities, emphasis was placed on the hypernuclear experiments, K-decay experiments, and later, the long-base-line neutrino experiment (K2K), which were successfully carried out. Although the TRISTAN experiment was unable to find the top quark, the CP-test experiments at TRISTAN-II (KEKB) have proven the Kobayashi-Maskawa theory successfully. During the last three years of my tenure in KEK, I served as a science adviser to Minister of Education, and I was involved in international affairs of accelerator science. (author)

Picosecond CO2 laser for relativistic particle acceleration

International Nuclear Information System (INIS)

Pogorelsky, I.; Ben-Zvi, I.; Kimura, W.D.; Kurnit, N.A.; Kannari, F.

1994-01-01

A table-top 20-GW 50-ps CO 2 laser system is under operation at the Brookhaven Accelerator Test Facility. We compare laser performance with model predictions. Extrapolations suggest the possibility of compact terawatt CO 2 laser systems suitable as laser accelerator drivers and for other strong-field applications. Latest progress on an Inverse Cherenkov Laser Accelerator experiment is reported

NaPdPS{sub 4} and RbPdPS{sub 4}: systems with infinite straight ((1)/({infinity}))[PdPS{sub 4}]{sup -} chains soluble in polar solvents and the structure of cubic RbPdPS{sub 4}{l_brace}Rb{sub 0.33}P{sub 0.4}S{sub 2.23}O{sub x}{r_brace}

Energy Technology Data Exchange (ETDEWEB)

Coste, Servane; Hanko, Jason; Bujoli-Doeuff, Martine; Louarn, Guy; Evain, Michel; Brec, Raymond; Alonso, Bruno; Jobic, S; Kanatzidis, Mercouri G

2003-11-01

The synthesis, crystal structures, chemical and spectroscopic properties of NaPdPS{sub 4}, RbPdPS{sub 4}, and RbPdPS{sub 4}{l_brace}Rb{sub 0.33}P{sub 0.4}S{sub 2.23}O{sub x}{r_brace} are described. NaPdPS{sub 4}, RbPdPS{sub 4}, are isostructural and crystallize in the tetragonal system I4/mcm with cell parameters a=7.3074(8) A, c=12.2308(14) A and a=8.2954(3) A, c=12.2284(4) A respectively. RbPdPS{sub 4}{l_brace}Rb{sub 0.33}P{sub 0.4}S{sub 2.23}O{sub x}{r_brace} is cubic, space group Pm-3n and a=12.0042(2) A. All compounds contain the same ((1)/({infinity}))[PdPS{sub 4}]{sup -} chains made of alternating square planar Pd{sup 2+} cations and tetrahedral [PS{sub 4}]{sup 3-} anions. RbPdPS{sub 4}{l_brace}Rb{sub 0.33}P{sub 0.4}S{sub 2.23}O{sub x}{r_brace} contains co-crystallized highly disordered molecular species encapsulated within [Rb{sub 8}] cubic cavities. Spectroscopic solid state {sup 31}P NMR, infrared and Raman data as well as elemental analysis suggest that these species could be S{sub n}{sup 2-} (n=3 or 4) anions and possibly cationic [P{sub 4}S{sub 6}O]{sup 6+} fragments. NaPdPS{sub 4} and RbPdPS{sub 4} exhibit exfoliative dissolution in polar solvents giving rise to solutions that show signs of complex fluid behavior.

An Integration Testing Facility for the CERN Accelerator Controls System

CERN Document Server

Stapley, N; Bau, J C; Deghaye, S; Dehavay, C; Sliwinski, W; Sobczak, M

2009-01-01

A major effort has been invested in the design, development, and deployment of the LHC Control System. This large control system is made up of a set of core components and dependencies, which although tested individually, are often not able to be tested together on a system capable of representing the complete control system environment, including hardware. Furthermore this control system is being adapted and applied to CERN's whole accelerator complex, and in particular for the forthcoming renovation of the PS accelerators. To ensure quality is maintained as the system evolves, and toimprove defect prevention, the Controls Group launched a project to provide a dedicated facility for continuous, automated, integration testing of its core components to incorporate into its production process. We describe the project, initial lessons from its application, status, and future directions.

Control system for a heavy-ion accelerator complex K4 - K10

International Nuclear Information System (INIS)

Kotov, V.M.; Pose, R.

1992-01-01

Control systems for newly created accelerators, perhaps for the first time, may be designed almost only around international standards for communication and control techniques. This is also true for the project of a control system for the accelerator complex K4-K10 at the Joint Institute for Nuclear Research Dubna. Nevertheless, open systems architecture with construction principles being essential for modern systems of such big devices as particle accelerators leaves designers enough possibilities for solving even very sophisticated problems. (author)

Radio frequency systems for present and future accelerators

International Nuclear Information System (INIS)

Raka, E.C.

1987-01-01

Rf systems are described for the FNAL Main Ring and Tevatron Ring, CERN SPS and LEP, and HERA proton acceleration system, CERN PS e + e/sup minus/ acceleration system, and CERN EPA monochromatic cavity. Low impedance rf systems in CERN ISR, the Brookhaven CBA, and SSC are also discussed

Injection and transfer lines of the PS Booster

CERN Multimedia

Photographic Service

1972-01-01

In the foreground is the vacuum chamber for the 50 MeV proton beam coming from the Linac. The tank held by white frames houses the "Vertical Distributor", which deflects the Linac beam to the levels of the Booster's 4 superposed rings. After acceleration in the Booster, originally to 800 MeV, today to 1.4 GeV, the beams from the 4 rings are combined in the vertical plane and transfered to the 26 GeV PS. The "Recombination Line", intersecting the injection line, crosses the picture from left to right.

Status of the maintenance for the KEK 12GEV-PS main ring and power supply

International Nuclear Information System (INIS)

Sato, Hikaru; Igarashi, Susumu; Marutsuka, Katsumi; Mikawa, Katsuhiko; Shirakata, Masashi; Sueno, Tsuyoshi; Tokuda, Noboru

2004-01-01

More than 30 years passed since the KEK 12GeV-PS construction, some of accelerator equipments are highly radiated, especially the injection and the extraction equipments. In recent years, the higher intensity beam has been required for such as the long baseline neutrino oscillation experiment and rare decay experiments. Then, the circumference of the maintenance work has become severe. Further, almost equipments of main ring and power supply have deteriorated. Status of the Maintenance for the KEK 12GeV-PS main ring and power supply are presented. (author)

Evaluation of some commercial grade polymers as possible dosimeters for technological irradiations in electron accelerators

CERN Document Server

Bryl-Sandelewska, T

2002-01-01

Dosimetric properties of two kinds of clear polymethylmethacrylate (PMMA)and one kind of polystyrene (PS) sheets in technological accelerator irradiations, are presented. Absorbance of the sheets and its dependence on the dose have been measured at a suitable wavelength using a UV/VIS spectrophotometer. Both kind PMMA can be used for technological dose measurements but each of them in the different range of the doses (approx 3 to approx 30 kGy and approx 30 to above 200 kGy). Heating the samples after irradiation accelerates the stabilization of the absorbance, which change slowly during the storage of the samples if not heated.Absorbance of clear PS sheets decreases very much during the storage after irradiation, and heating of the samples does not accelerate the stabilization of the value. It can be said that the Ps investigated is not suitable for technological dose measurements in accelerator i radiations.

Evaluation of some commercial grade polymers as possible dosimeters for technological irradiations in electron accelerators

International Nuclear Information System (INIS)

Bryl-Sandelewska, T.; Panta, P.P.

2002-01-01

Dosimetric properties of two kinds of clear polymethylmethacrylate (PMMA)and one kind of polystyrene (PS) sheets in technological accelerator irradiations, are presented. Absorbance of the sheets and its dependence on the dose have been measured at a suitable wavelength using a UV/VIS spectrophotometer. Both kind PMMA can be used for technological dose measurements but each of them in the different range of the doses (∼ 3 to ∼30 kGy and ∼ 30 to above 200 kGy). Heating the samples after irradiation accelerates the stabilization of the absorbance, which change slowly during the storage of the samples if not heated.Absorbance of clear PS sheets decreases very much during the storage after irradiation, and heating of the samples does not accelerate the stabilization of the value. It can be said that the Ps investigated is not suitable for technological dose measurements in accelerator i radiations. (author)

Physics at the AD/PS/SPS (1/4)

CERN Multimedia

CERN. Geneva

2012-01-01

Lecture 1: The CERN injector complex and beams for non-LHC physics. The various machines and beam lines in the CERN injector complex are presented, from the linacs to the SPS. Special emphasis is given to the beam lines at the PS and SPS machines: AD, North and East Areas, nTOF and CNGS and HiRadMad as well as the ion beams. A short outlook is given to possible future upgrades and projects.

GPU-accelerated depth map generation for X-ray simulations of complex CAD geometries

Science.gov (United States)

Grandin, Robert J.; Young, Gavin; Holland, Stephen D.; Krishnamurthy, Adarsh

2018-04-01

Interactive x-ray simulations of complex computer-aided design (CAD) models can provide valuable insights for better interpretation of the defect signatures such as porosity from x-ray CT images. Generating the depth map along a particular direction for the given CAD geometry is the most compute-intensive step in x-ray simulations. We have developed a GPU-accelerated method for real-time generation of depth maps of complex CAD geometries. We preprocess complex components designed using commercial CAD systems using a custom CAD module and convert them into a fine user-defined surface tessellation. Our CAD module can be used by different simulators as well as handle complex geometries, including those that arise from complex castings and composite structures. We then make use of a parallel algorithm that runs on a graphics processing unit (GPU) to convert the finely-tessellated CAD model to a voxelized representation. The voxelized representation can enable heterogeneous modeling of the volume enclosed by the CAD model by assigning heterogeneous material properties in specific regions. The depth maps are generated from this voxelized representation with the help of a GPU-accelerated ray-casting algorithm. The GPU-accelerated ray-casting method enables interactive (> 60 frames-per-second) generation of the depth maps of complex CAD geometries. This enables arbitrarily rotation and slicing of the CAD model, leading to better interpretation of the x-ray images by the user. In addition, the depth maps can be used to aid directly in CT reconstruction algorithms.

Two members of the CERN personnel receive the 2002 Accelerator Prize

CERN Multimedia

2002-01-01

Kurt H bner and Frank Zimmermann have been awarded the 2002 Accelerator Prize by the Interdivisional Group on Accelerators of the European Physical Society (EPS-IGA).   Kurt H bner Frank Zimmermann Kurt H bner is well known to CERN, as he was Director of Accelerators from 1994 to 2001, after having been PS Division Leader. A member of the CERN personnel since 1966, Kurt H bner, who is of Austrian nationality, has taken part in the design and operation of many accelerators including the PS, the ISR and LEP. He has received the award for his major contributions to accelerator physics and for his excellent leadership in this field. In its citation, the Prize Selection Committee stated that «he has provided guidance for generations of accelerator physicists and engineers, thereby contributing immensely to the prosperity of accelerators at CERN and many other laboratories around the world.» Frank Zimmermann has been awarded the prize for an individual in the early part of his or her career who has made a rece...

Academic Training Lecture Regular Programme: Physics at the AD/PS/SPS

CERN Multimedia

2012-01-01

Physics at the AD/PS/SPS (1/4), by Lau Gatignon (CERN).   Monday, June 18, 2012 from 11:00 to 12:00 (Europe/Zurich) at CERN ( 222-R-001 - Filtration Plant )   Lecture 1: The CERN injector complex and beams for non-LHC physics. The various machines and beam lines in the CERN injector complex are presented, from the linacs to the SPS. Special emphasis is given to the beam lines at the PS and SPS machines: AD, North and East Areas, nTOF and CNGS and HiRadMad as well as the ion beams. A short outlook is given to possible future upgrades and projects.   More information here.  

Electron pulse shaping in the FELIX RF accelerator

International Nuclear Information System (INIS)

Weits, H.H.; Geer, C.A.J. van der; Oepts, D.; Meer, A.F.G. van der

1999-01-01

The FELIX free-electron laser uses short pulses of relativistic electrons produced by an RF accelerator. The design target for the duration of these electron bunches was around 3 ps. In experiments we observed that the bunches emit coherently enhanced spontaneous emission (CSE) when they travel through an undulator. It was demonstrated that the power level of the CSE critically depends on the settings of the accelerator. In this article we seek to explain these observations by studying the length and shape of the electron bunches as a function of the settings of the accelerator. A particle-tracking model was used to simulate the acceleration and transport processes. These include bunch compression in a 14-cell travelling wave buncher cavity, acceleration in a travelling wave linear accelerator, and passage through a (dispersive) chicane structure. The effect of the phase setting of the RF accelerating field with respect to the arrival time of the electron bunch in each accelerator structure was studied. The parameter range of the simulations is related to that of an actual free-electron laser experiment using these bunches. We find that, for specific settings of the accelerating system, electron pulses with a length of 350 μm FWHM (1 ps) are produced. The charge in the bunch rises steeply within a distance of 25 μm. This bunch shape explains the high level of coherently enhanced spontaneous emission observed in the FELIX laser. (author)

Proof on principle experiments of laser wakefield acceleration

International Nuclear Information System (INIS)

Nakajima, K.; Kawakubo, T.; Nakanishi, H.

1994-01-01

The principle of laser wakefield particle acceleration has been tested by the Nd:glass laser system providing a short pulse with a power of 10 TW and a duration of 1 ps. Electrons accelerated up to 18 MeV/c have been observed by injecting 1 MeV/c electrons emitted from a solid target by an intense laser impact. The accelerating field gradient of 30 GeV/m is inferred. (author)

International Scoping Study of a Future Accelerator Neutrino Complex

International Nuclear Information System (INIS)

Zisman, Michael S.

2006-01-01

The International Scoping Study (ISS), launched at NuFact05 to evaluate the physics case for a future neutrino facility, along with options for the accelerator complex and detectors, is laying the foundations for a subsequent conceptual-design study. It is hosted by Rutherford Appleton Laboratory (RAL) and organized by the international community, with participants from Europe, Japan, and the U.S. Here we cover the work of the Accelerator Working Group. For the 4-MW proton driver, linacs, synchrotrons, and Fixed-Field Alternating Gradient (FFAG) rings are considered. For targets, issues of both liquid-metal and solid materials are examined. For beam conditioning, (phase rotation, bunching, and ionization cooling), we evaluate schemes both with and without cooling, the latter based on scaling-FFAG rings. For acceleration, we examine scaling FFAGs and hybrid systems comprising linacs, dogbone RLAs, and non-scaling FFAGs. For the decay ring, we consider racetrack and triangular shapes, the latter capable of simultaneously illuminating two different detectors at different long baselines. Comparisons are made between various technical approaches to identify optimum design choices

Determination of grafting conversion degree in PS/PS-graft-POSS/POSS hybrid nanocomposites obtained through reactive processing

International Nuclear Information System (INIS)

Bianchi, Otavio; Repenning, Gustavo B.; Mauler, Raquel S.; Oliveira, Ricardo V.B.; Canto, Leonardo B.

2011-01-01

Hybrid nanocomposites of polystyrene (PS) and polyhedral oligomeric silsesquioxanes (POSS) - PS/PS-graft-POSS/POSS - with different grafting degrees were prepared by reactive melt processing using dicumyl peroxide (DCP) as initiator in the presence or absence of styrene monomer as radical transfer agent. Gel permeation chromatography (GPC) using triple-detector and proton nuclear magnetic resonance (NMR 1 H) analyses were used together to determine the conversion degree of PS-graft-POSS as a function of the reactive processing conditions adopted. GPC was employed to evaluate the effects of grafting (PS-graft-POSS) and PS chains degradation (β scission) that occur simultaneously during processing on the variation of average molecular masses and distributions for each PS/POSS sample. PS/POSS systems processed with styrene showed higher weight average molecular weights (M w ) and lower polydispersity indexes (M w /M n ), as a result of higher grafting (PS-graft-POSS) conversion (28-40%) and lower PS chain degradation level, as compared to PS/POSS systems processed without styrene in which the degree of grafting conversion was around 25-28%. (author)

Electrostatic septum for "Continuous Transfer" from PS to SPS

CERN Multimedia

CERN PhotoLab

1982-01-01

For "Continuous Transfer" to the SPS, the PS beam, after acceleration, is peeled off in 5 turns. To minimize losses, the magnetic septa are preceded by an electrostatic septum in straight section 31. We see the inner part of it, on a lab-bench. The first part consists of W-wires, the second part is a Mo-foil. The circulating beam passes through the opening, the ejected beam at the outside (above the wires, in this picture). This assembly is the anode-part, the cathode is not shown.

Possibility of a higher PSB to PS transfer energy

CERN Document Server

Hanke, K; Blas, A; Borburgh, J; Bozzini, D; Buzio, M; Capatina, O; Carli, C; Dobers, T; Fernandez, L; Findlay, A; Folch, R; Gilardoni, S; Gilbert, N; Hermanns, T; Mahner, E; Mikulec, B; Newborough, A; Nonis, M; Olek, S; Paoluzzi, M; Pittet, S; Ruehl, I; Rumolo, G; Steerenberg, R; Tan, J; Tommasini, D; Weterings, W; Widorski, M; Shaposhnikova, E

2011-01-01

Following the Chamonix 2010 workshop a task force has been set up to study the feasibility and the impact of an energy upgrade of the PS Booster from the present 1.4 GeV to about 2 GeV. The working group has confirmed the feasibility of such an upgrade, and analysed in detail the impact on the accelerator hardware along with a cost estimate and a tentative planning. The outcome of the task force will be summarized, with particular emphasis on the remaining limitations, risks and uncertainties.

Linear Accelerator Laboratory

International Nuclear Information System (INIS)

1976-01-01

This report covers the activity of the Linear Accelerator Laboratory during the period June 1974-June 1976. The activity of the Laboratory is essentially centered on high energy physics. The main activities were: experiments performed with the colliding rings (ACO), construction of the new colliding rings and beginning of the work at higher energy (DCI), bubble chamber experiments with the CERN PS neutrino beam, counter experiments with CERN's PS and setting-up of equipment for new experiments with CERN's SPS. During this period a project has also been prepared for an experiment with the new PETRA colliding ring at Hamburg. On the other hand, intense collaboration with the LURE Laboratory, using the electron synchrotron radiation emitted by ACO and DCI, has been developed [fr

50 MeV Run of the IOTA / FAST Electron Accelerator

Energy Technology Data Exchange (ETDEWEB)

Edstrom Jr., D.; et al.

2017-02-02

The low-energy section of the photoinjector-based electron linear accelerator at the Fermilab Accelerator Science & Technology (FAST) facility was recently commissioned to an energy of 50 MeV. This linear accelerator relies primarily upon pulsed SRF acceleration and an optional bunch compressor to produce a stable beam within a large operational regime in terms of bunch charge, total average charge, bunch length, and beam energy. Various instrumentation was used to characterize fundamental properties of the electron beam including the intensity, stability, emittance, and bunch length. While much of this instrumentation was commissioned in a 20 MeV running period prior, some (including a new Martin- Puplett interferometer) was in development or pending installation at that time. All instrumentation has since been recommissioned over the wide operational range of beam energies up to 50 MeV, intensities up to 4 nC/pulse, and bunch structures from ~1 ps to more than 50 ps in length.

ps-ro Fuzzy Open(Closed Functions and ps-ro Fuzzy Semi-Homeomorphism

Directory of Open Access Journals (Sweden)

Pankaj Chettri

2015-11-01

Full Text Available The aim of this paper is to introduce and characterize some new class of functions in a fuzzy topological space termed as ps-ro fuzzy open(closed functions, ps-ro fuzzy pre semiopen functions and ps-ro fuzzy semi-homeomorphism. The interrelation among these concepts and also their relations with the parallel existing concepts are established. It is also shown with the help of examples that these newly introduced concepts are independent of the well known existing allied concepts.

Effects of the plant growth-promoting bacterium Burkholderia phytofirmans PsJN throughout the life cycle of Arabidopsis thaliana.

Directory of Open Access Journals (Sweden)

María Josefina Poupin

Full Text Available Plant growth-promoting rhizobacteria (PGPR induce positive effects in plants, such as increased growth or reduced stress susceptibility. The mechanisms behind PGPR/plant interaction are poorly understood, as most studies have described short-term responses on plants and only a few studies have analyzed plant molecular responses under PGPR colonization. Here, we studied the effects of the PGPR bacterial model Burkholderiaphytofirmans PsJN on the whole life cycle of Arabidopsis thaliana plants. We reported that at different plant developmental points, strain PsJN can be found in the rhizosphere and also colonizing their internal tissues. In early ontogeny, strain PsJN increased several growth parameters and accelerated growth rate of the plants. Also, an Arabidopsis transcriptome analysis revealed that 408 genes showed differential expression in PsJN-inoculated plants; some of these genes are involved in stress response and hormone pathways. Specifically, genes implicated in auxin and gibberellin pathways were induced. Quantitative transcriptional analyses of selected genes in different developmental stages revealed that the beginning of these changes could be evidenced early in development, especially among the down-regulated genes. The inoculation with heat-killed bacteria provoked a more severe transcriptional response in plants, but was not able to induce plant growth-promotion. Later in ontogeny, the growth rates of inoculated plants decreased with respect to the non-inoculated group and, interestingly, the inoculation accelerated the flowering time and the appearance of senescence signs in plants; these modifications correlate with the early up-regulation of flowering control genes. Then, we show that a single inoculation with a PGPR could affect the whole life cycle of a plant, accelerating its growth rate and shortening its vegetative period, both effects relevant for most crops. Thus, these findings provide novel and interesting aspects

Supervision Application for the New Power Supply of the CERN PS (POPS)

CERN Document Server

Milcent, H; Gonzalez-Berges, M; Voitier, A

2011-01-01

The power supply system for the magnets of the CERN PS has been recently upgraded to a new system called POPS (POwer for PS). The old mechanical machine has been replaced by a system based on capacitors. The equipments as well as the low level controls have been provided by an external company (CONVERTEAM). The supervision application has been developed at CERN reusing the technologies and tools used for the LHC Accelerator and Experiments (UNICOS and JCOP frameworks, SIMATIC WinCC Open Architecture SCADA tool). The paper describes the full architecture of the control application, and the challenges faced for the integration with an outsourced system. The benefits of reusing the CERN industrial control frameworks and the required adaptations will be discussed. Finally, the initial operational experience will be presented.

Last PS magnet refurbished

CERN Multimedia

2009-01-01

PS Magnet Refurbishment Programme Completed. The 51st and final refurbished magnet was transported to the PS on Tuesday 3 February. The repair and consolidation work on the PS started back in 2003 when two magnets and a busbar connection were found to be faulty during routine high-voltage tests. The cause of the fault was a combination of age and radiation on electrical insulation. After further investigation the decision was taken to overhaul half of the PS’s 100 magnets to reduce the risk of a similar fault. As from 20 February the PS ring will start a five-week test programme to be ready for operation at the end of March.

Facile Synthesis of Mono-Dispersed Polystyrene (PS/Ag Composite Microspheres via Modified Chemical Reduction

Directory of Open Access Journals (Sweden)

Wen Zhu

2013-12-01

Full Text Available A modified method based on in situ chemical reduction was developed to prepare mono-dispersed polystyrene/silver (PS/Ag composite microspheres. In this approach; mono-dispersed PS microspheres were synthesized through dispersion polymerization using poly-vinylpyrrolidone (PVP as a dispersant at first. Then, poly-dopamine (PDA was fabricated to functionally modify the surfaces of PS microspheres. With the addition of [Ag(NH32]+ to the PS dispersion, [Ag(NH32]+ complex ions were absorbed and reduced to silver nanoparticles on the surfaces of PS-PDA microspheres to form PS/Ag composite microspheres. PVP acted both as a solvent of the metallic precursor and as a reducing agent. PDA also acted both as a chemical protocol to immobilize the silver nanoparticles at the PS surface and as a reducing agent. Therefore, no additional reducing agents were needed. The resulting composite microspheres were characterized by TEM, field emission scanning electron microscopy (FESEM, energy-dispersive X-ray spectroscopy (EDS, XRD, UV-Vis and surface-enhanced Raman spectroscopy (SERS. The results showed that Ag nanoparticles (NPs were homogeneously immobilized onto the PS microspheres’ surface in the presence of PDA and PVP. PS/Ag composite microspheres were well formed with a uniform and compact shell layer and were adjustable in terms of their optical property.

Optically isolated electronic trigger system for experiments on a subnanosecond time scale with a pulsed Van de Graaff electron accelerator

International Nuclear Information System (INIS)

Luthjens, L.H.; Vermeulen, M.J.W.; Hom, M.L.

1980-01-01

An optically isolated electronic trigger system for a pulsed Van de Graaff electron accelerator, producing an external pretrigger pulse 75 ns before arrival of the electron pulse at the target, is described. The total time jitter between trigger signal and electron pulse is 50 ps. The measurement of optical and electrical transients on a subnanosecond time scale with a sequential sampling oscilloscope is demonstrated. The contribution of various parts of the equipment to the total jitter is discussed. Those contributions to the jitter due to the electron transit time fluctuations in the accelerator assuming a constant acceleration voltage gradient and to the shot noise in the photomultiplier detector of the trigger system are calculated to be 5 ps and 12 to 21 ps respectively. Comparison with the experimental results leads to the conclusion that a considerable part of the total jitter may be attributed to acceleration voltage gradient fluctuations, to accelerator vibrations and possibly to density fluctuations in the insulation gas. Possible improvements of the trigger system are discussed. The apparatus is used for pulse radiolysis experiments with subnanosecond time resolution down to 100 ps in combination with subnanosecond time duration electron pulses

Study of the beam-cavity interaction in the CERN PS 10 MHz cavities and investigation of hardware solutions to reduce beam loading

CERN Document Server

AUTHOR|(CDS)2086984; Palumbo, Luigi

In the Proton Synchrotron (PS), where the LHC protons longitudinal structure (bunch spacing) is determined as the result of a sophisticated series of Radio Frequency (RF) gymnastics, collective effects were identified as a major limitation to the achievable beam current delivered to the LHC. Dedicated machine development studies pointed out the RF cavities to be one of the major source of instability in the PS. In particular, the 10 MHz RF system, responsible for beam acceleration, was identified as the most probable impedance source in the machine. The cavity impedance limits the circulating intensity in the accelerator since the beam-induced voltage could trigger longitudinal instabilities causing beam losses. For this reason the cavity impedance seen by the beam must be kept as low as possible. In the framework of the LHC Injector Upgrade (LIU) project, the present PS 10 MHz RF system requires an upgrade, in order to reach higher beam intensities and to reduce beam loading. This thesis focuses on the impro...

Design study of the large hadron electron collider and a rapid cycling synchrotron as alternative to the PS booster upgrade at CERN

International Nuclear Information System (INIS)

Fitterer, Miriam

2013-01-01

With the Large Hadron Collider (LHC) the exploration of particle physics at center of mass energies at the TeV scale has begun. To extend the discovery potential of the LHC, a major upgrade is foreseen around 2020 of the LHC itself and the LHC injectors - the chain of accelerators preparing the beam for the LHC. One of the injectors - the second one in the chain - is the Proton Synchrotron (PS) Booster. Its performance is currently limited by the space-charge effect, which is the effect of the electromagnetic field of the particle beam on itself. This effect becomes weaker with higher energy, and therefore an energy upgrade of the PS Booster to 2 GeV maximum beam energy is foreseen. As the PS Booster is with its 40 years already an old machine, the construction of a new accelerator, a Rapid Cycling Synchrotron (RCS), to replace the PS Booster has been proposed. In this thesis different options for the beam guidance in the RCS - referred to as lattice and optics - are studied, followed by a more general comparison of different lattices and optics and their performance under consideration of the space-charge effect. To further complement the LHC physics program, also the possibility of deep inelastic lepton-nucleon scattering at the LHC has been suggested, referred to as Large Hadron Electron Collider (LHeC). In this case the proton beam of the LHC collides with the electron beam, which is accelerated in a separate newly built machine. Two options are considered as electron accelerator: a new energy recovery linac - the Linac-Ring option - and the installation of an electron ring in the existing LHC tunnel - the Ring-Ring option. One of the main challenges of the Ring-Ring option is the integration of the electron ring in the current LHC tunnel. A layout, lattice and optics of the electron accelerator is developed in this thesis, which meets the requirements with regard to integration and reaches the beam parameters demanded by the particle physics experiments.

Design study of the large hadron electron collider and a rapid cycling synchrotron as alternative to the PS booster upgrade at CERN

Energy Technology Data Exchange (ETDEWEB)

Fitterer, Miriam

2013-02-22

With the Large Hadron Collider (LHC) the exploration of particle physics at center of mass energies at the TeV scale has begun. To extend the discovery potential of the LHC, a major upgrade is foreseen around 2020 of the LHC itself and the LHC injectors - the chain of accelerators preparing the beam for the LHC. One of the injectors - the second one in the chain - is the Proton Synchrotron (PS) Booster. Its performance is currently limited by the space-charge effect, which is the effect of the electromagnetic field of the particle beam on itself. This effect becomes weaker with higher energy, and therefore an energy upgrade of the PS Booster to 2 GeV maximum beam energy is foreseen. As the PS Booster is with its 40 years already an old machine, the construction of a new accelerator, a Rapid Cycling Synchrotron (RCS), to replace the PS Booster has been proposed. In this thesis different options for the beam guidance in the RCS - referred to as lattice and optics - are studied, followed by a more general comparison of different lattices and optics and their performance under consideration of the space-charge effect. To further complement the LHC physics program, also the possibility of deep inelastic lepton-nucleon scattering at the LHC has been suggested, referred to as Large Hadron Electron Collider (LHeC). In this case the proton beam of the LHC collides with the electron beam, which is accelerated in a separate newly built machine. Two options are considered as electron accelerator: a new energy recovery linac - the Linac-Ring option - and the installation of an electron ring in the existing LHC tunnel - the Ring-Ring option. One of the main challenges of the Ring-Ring option is the integration of the electron ring in the current LHC tunnel. A layout, lattice and optics of the electron accelerator is developed in this thesis, which meets the requirements with regard to integration and reaches the beam parameters demanded by the particle physics experiments.

Understanding Craftsman’s Creativity in a Framework of Person, Process, Product and Press (4Ps)

DEFF Research Database (Denmark)

Zhang, Hui; Zhou, Chunfang; Tanggaard, Lene

2016-01-01

, Process, Product, and Press (4Ps) This research question drives to develop a theoretical study bridging two areas of creativity and craftsman’s work. This will further indicate craftsman’s working practice is full of complexity that stimulates creative behavior and that also requires a systematic view...... to understand craftsman’s creativity as involving interaction between 4Ps....

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.

Science.gov (United States)

Lee, Ju-Hyun; Yu, W Haung; Kumar, Asok; Lee, Sooyeon; Mohan, Panaiyur S; Peterhoff, Corrinne M; Wolfe, Devin M; Martinez-Vicente, Marta; Massey, Ashish C; Sovak, Guy; Uchiyama, Yasuo; Westaway, David; Cuervo, Ana Maria; Nixon, Ralph A

2010-06-25

Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin-1 (PS1). In PS1 null blastocysts, neurons from mice hypomorphic for PS1 or conditionally depleted of PS1, substrate proteolysis and autophagosome clearance during macroautophagy are prevented as a result of a selective impairment of autolysosome acidification and cathepsin activation. These deficits are caused by failed PS1-dependent targeting of the v-ATPase V0a1 subunit to lysosomes. N-glycosylation of the V0a1 subunit, essential for its efficient ER-to-lysosome delivery, requires the selective binding of PS1 holoprotein to the unglycosylated subunit and the Sec61alpha/oligosaccharyltransferase complex. PS1 mutations causing early-onset AD produce a similar lysosomal/autophagy phenotype in fibroblasts from AD patients. PS1 is therefore essential for v-ATPase targeting to lysosomes, lysosome acidification, and proteolysis during autophagy. Defective lysosomal proteolysis represents a basis for pathogenic protein accumulations and neuronal cell death in AD and suggests previously unidentified therapeutic targets.

Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system.

Science.gov (United States)

Takayama, Kazuo; Igai, Keisuke; Hagihara, Yasuko; Hashimoto, Rina; Hanawa, Morifumi; Sakuma, Tetsushi; Tachibana, Masashi; Sakurai, Fuminori; Yamamoto, Takashi; Mizuguchi, Hiroyuki

2017-05-19

Genome editing research of human ES/iPS cells has been accelerated by clustered regularly interspaced short palindromic repeats/CRISPR-associated 9 (CRISPR/Cas9) and transcription activator-like effector nucleases (TALEN) technologies. However, the efficiency of biallelic genetic engineering in transcriptionally inactive genes is still low, unlike that in transcriptionally active genes. To enhance the biallelic homologous recombination efficiency in human ES/iPS cells, we performed screenings of accessorial genes and compounds. We found that RAD51 overexpression and valproic acid treatment enhanced biallelic-targeting efficiency in human ES/iPS cells regardless of the transcriptional activity of the targeted locus. Importantly, RAD51 overexpression and valproic acid treatment synergistically increased the biallelic homologous recombination efficiency. Our findings would facilitate genome editing study using human ES/iPS cells. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice

Directory of Open Access Journals (Sweden)

Lianne Hoeijmakers

2018-03-01

Full Text Available Life-time experiences are thought to influence the risk to develop the neurodegenerative disorder Alzheimer’s disease (AD. In particular, early-life stress (ES may modulate the onset and progression of AD. There is recent evidence by our group and others that AD-related neuropathological progression and the associated neuroimmune responses are modulated by ES in the classic APPswe/PS1dE9 mouse model for AD. We here extend our previous study on ES mediated modulation of neuropathology and neuroinflammation and address in the same cohort of mice whether ES accelerates and/or aggravates AD-induced cognitive decline and alterations in the process of adult hippocampal neurogenesis (AHN, a form of brain plasticity. Chronic ES was induced by limiting bedding and nesting material during the first postnatal week and is known to induce cognitive deficits by 4 months in wild type (WT mice. The onset of cognitive decline in APP/PS1 mice generally starts around 6 months of age. We here tested mice at ages 2–4 months to study acceleration and at ages 8–10 months for aggravation of the APP/PS1 phenotype. ES-exposed WT and APP/PS1 mice were able to perform the object recognition (ORT and location tasks (OLT at 2 months of age. Interestingly, at 3 months, ES induced impairments in the performance of the OLT in WT, but not in APP/PS1 mice. APP/PS1 mice exhibited alterations in hippocampal cell proliferation and differentiation, but ES exposure did not further change this. At 9 months, APP/PS1 mice exhibited impaired performance in the Morris Water Maze (MWM task, as well as reductions in markers of the AHN process, which were not further modulated by ES exposure. In addition, we observed a so far unreported hyperactivity in ES-exposed mice at 8 months of age, which hampered assessment of cognitive functions in the ORT and OLT. In conclusion, while ES has been reported to modulate AD neuropathology and neuroinflammation before, it failed to accelerate or

Synthesis and Characterization of the Rubidium Thiophosphate Rb 6 (PS 5 )(P 2 S 10 ) and the Rubidium Silver Thiophosphates Rb 2 AgPS 4 , RbAg 5 (PS 4 ) 2 and Rb 3 Ag 9 (PS 4 ) 4

KAUST Repository

Alahmary, Fatimah S.; Davaasuren, Bambar; Khanderi, Jayaprakash; Rothenberger, Alexander

2016-01-01

The metal thiophosphates Rb2AgPS4 (2), RbAg5(PS4)2 (3), and Rb3Ag9(PS4)4 (4) were synthesized by stoichiometric reactions, whereas Rb6(PS5)(P2S10) (1) was prepared with excess amount of sulfur. The compounds crystallize as follows: 1 monoclinic, P21

Radiation protection activities around the CERN accelerators

International Nuclear Information System (INIS)

Forkel-Wirth, D.; Silari, M.

1999-01-01

As planned, the PS complex started up at the end of March 1998. The machines worked smoothly and the availability of the beams reached from 90% up to 96%. New record intensities were achieved for the 14 GeV/c protons for the SPS fixed-target operation and for the Pb 53+ ions. The year 1998 saw the PS complex busy with the transformation of the Antiproton Accumulator (ACOL) into the Antiproton Decelerator (AD). This project is almost finished and the first test beams of protons have already been successfully decelerated in the machine. It is envisaged that the physicists will receive a 100 MeV antiproton beam from October 1999 onwards. Major modifications of the East Hall were required due to the installation of the DIRAC experiment, some test facilities for secondary particles used by LHC experimental groups, and an irradiation area (IRRAD1) for radiation hardness tests of LHC components. The first beams to experimental areas of the East Hall were already sent from July 1998 onwards. The ISOLDE mass separator delivered 275 shifts of radioactive beams of high quality to its user community. The SPS fixed-target programme lasted from 1 April to 30 November. The successful start-up of the accelerators for both the proton and lead-ion periods was followed by stable machine running and by record intensities. The year 1998 marked the end of the operation of the neutrino beam. The dismantling of CHORUS began before the end of the year, to be followed by that of the NOMAD experiment early in 1999

The Proton Beams for the New Time-of-Flight Neutron Facility at the CERN-PS

CERN Document Server

Cappi, R; Métral, G

2000-01-01

The experimental determination of neutron cross sections in fission and capture reactions as a function of the neutron energy is of primary importance in nuclear physics. Recent developments at CERN and elsewhere have shown that many fields of research and development, such as the design of Accelerator-Driven Systems (ADS) for nuclear waste incineration, nuclear astrophysics, fundamental nuclear physics, dosimetry for radiological protection and therapy, would benefit from a better knowledge of neutron cross sections. A neutron facility at the CERN-PS has been proposed with the aim of carrying out a systematic and high resolution study of neutron cross sections through Time-Of-Flight (n-TOF) measurement. The facility requires a high intensity proton beam (about 0.7x1013 particles/bunch) distributed in a short bunch (about 25 ns total length) to produce the neutrons by means of a spallation process in a lead target. To achieve these characteristics, a number of complex beam gymnastics have to be performed. All...

Electron cloud in the CERN accelerator complex

CERN Document Server

AUTHOR|(CDS)2069325; Bartosik, Hannes; Belli, Eleonora; Iadarola, Giovanni; Li, Kevin Shing Bruce; Mether, Lotta Maria; Romano, Annalisa; Schenk, Michael

2016-01-01

Operation with closely spaced bunched beams causes the build-up of an Electron Cloud (EC) in both the LHC and the two last synchrotrons of its injector chain (PS and SPS). Pressure rise and beam instabilities are observed at the PS during the last stage of preparation of the LHC beams. The SPS was affected by coherent and incoherent emittance growth along the LHC bunch train over many years, before scrubbing has finally suppressed the EC in a large fraction of the machine. When the LHC started regular operation with 50 ns beams in 2011, EC phenomena appeared in the arcs during the early phases, and in the interaction regions with two beams all along the run. Operation with 25 ns beams (late 2012 and 2015), which is nominal for LHC, has been hampered by EC induced high heat load in the cold arcs, bunch dependent emittance growth and degraded beam lifetime. Dedicated and parasitic machine scrubbing is presently the weapon used at the LHC to combat EC in this mode of operation. This talk summarises the EC experi...

Accelerating RF cavity of the Booster

CERN Multimedia

CERN PhotoLab

1981-01-01

Each of the 4 PS Booster rings has a single accelerating cavity. It consists of 2 quarter-wave ferrite-loaded resonators. There are 2 figure-of-eight loops on the ferrite loads for tuning the frequency throughout the acceleration cycle, from 3 to 8 MHz (from 50 MeV at injection to the original Booster energy of 800 MeV, 2 GeV today). The cavities have a flat design, to fit the ring-to-ring distance of 36 cm. The tube for forced-air cooling is visible in the left front. See also 8301084.

Accelerating RF cavity of the Booster

CERN Multimedia

CERN PhotoLab

1983-01-01

Each of the 4 PS Booster rings has a single accelerating cavity.It consists of 2 quarter-wave ferrite-loaded resonators. 2 figure-of-eight loops tune the frequency throughout the accelerating cycle, from 3 to 8 MHz (from 50 MeV at injection to the original Booster energy of 800 MeV, 2 GeV today). The cavities have a flat design, to fit the ring-to-ring distance of 36 cm, and are forced-air cooled. The 2 round objects in the front-compartments are the final-stage power-tetrodes. See also 8111095.

PS Booster - Festive colloquium

CERN Multimedia

2012-01-01

A festive colloquium will be held to celebrate the 40th anniversary of the PS Booster on Friday, 28 September at 2 p.m. in the CERN council chamber. The meeting will be open to everybody. Read more on the PS Booster in the CERN Bulletin and in the CERN Courier.

Symmetry of dipositronium Ps2

International Nuclear Information System (INIS)

Schrader, D.M.

2004-01-01

We work out the complete symmetry and spin problem for diatomic positronium Ps 2 for the ground and singly excited states of zero orbital angular momentum. The general form of the wave function for each state is given, with due regard to charge conjugation parity. Annihilation rates are discussed, and correlations to dissociation products are deduced. We indicate how the approach is extensible to larger aggregates: i.e., PsPs n , n>2

Is there a temperature? conceptual challenges at high energy, acceleration and complexity

CERN Document Server

Sándor Biró, Tamás

2011-01-01

Physical bodies can be hot or cold, moving or standing,simple or complex. In all such cases one assumes that their respective temperature is a well defined attribute.  What if, however, the ordinary measurement of temperature by direct body contact is not possible?  One conjectures its value, and yes, its very existence, by reasoning based on basic principles of thermodynamics. Is There a Temperature?  Conceptual Challenges at High Energy, Acceleration and Complexity, by Dr. Tamás Sándor Bíró, begins by asking the questions “Do we understand and can we explain in a unified framework the temperature of distant radiation sources, including event horizons, and that of the quark matter produced in high energy accelerator experiments? Or the astounding fluctuations on financial markets?” The book reviews the concept of temperature from its beginnings through the evolution of classical thermodynamics and atomic statistical physics through contemporary models of high energy particle matter.  Based on the...

Shielding considerations for an electron linear accelerator complex for high energy physics and photonics research

International Nuclear Information System (INIS)

Holmes, J.A.; Huntzinger, C.J.

1987-01-01

Radiation shielding considerations for a major high-energy physics and photonics research complex which comprise a 50 MeV electron linear accelerator injector, a 1.0 GeV electron linear accelerator and a 1.3 GeV storage ring are discussed. The facilities will be unique because of the close proximity of personnel to the accelerator beam lines, the need to adapt existing facilities and shielding materials and the application of strict ALARA dose guidelines while providing maximum access and flexibility during a phased construction program

CHANGE@CERN:Task Force 5 : Restructuring the accelerator sector

CERN Document Server

2002-01-01

The last of our series on the Task Forces. PS accelerator 'We had a clear mandate, which we could approach in a logical way', explains Steve Myers, Head of SL Division and convenor of Task Force 5, 'To avoid duplication of effort in the accelerator sector through a restructuring that would lead to greater efficiency and flexibility and so release resources for the LHC.' The implementation of all their recommendations is already underway, albeit with different time scales. In 2001 the accelerator sector involved more than 900 staff members in three divisions (LHC, PS and SL) and one unit (AC), working in 141 sections within 34 groups. The first step for the Task Force was to identify major activities within the sector and to set up inter-divisional working groups to review these activities (16 in all), identifying the technologies and the numbers of staff associated with each activity. The working groups were also asked to propose ways of grouping the activities into a new more efficient organizational stru...

Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution.

Science.gov (United States)

Sun, Zhenzhen; Xie, Yujie; Chen, Yintong; Yang, Qinghu; Quan, Zhenzhen; Dai, Rongji; Qing, Hong

2018-05-01

γ-Secretase has been a therapeutical target for its key role in cleaving APP to generate β-amyloid (Aβ), the primary constituents of senile plaques and a hallmark of Alzheimer's disease (AD) pathology. Recently, γ-secretase-associating proteins showed promising role in specifically modulating APP processing while sparing Notch signaling; however, the underlying mechanism is still unclear. A co-immunoprecipitation (Co-IP) coupled with mass spectrometry proteomic assay for Presenilin1 (PS1, the catalytic subunit of γ-secretase) was firstly conducted to find more γ-secretase-associating proteins. Gene ontology analysis of these results identified Rab21 as a potential PS1 interacting protein, and the interaction between them was validated by reciprocal Co-IP and immunofluorescence assay. Then, molecular and biochemical methods were used to investigate the effect of Rab21 on APP processing. Results showed that overexpression of Rab21 enhanced Aβ generation, while silencing of Rab21 reduced the accumulation of Aβ, which resulted due to change in γ-secretase activity rather than α- or β-secretase. Finally, we demonstrated that Rab21 had no effect on γ-secretase complex synthesis or metabolism but enhanced PS1 endocytosis and translocation to late endosome/lysosome. In conclusion, we identified a novel γ-secretase-associating protein Rab21 and illustrate that Rab21 promotes γ-secretase internalization and translocation to late endosome/lysosome. Moreover, silencing of Rab21 decreases the γ-secretase activity in APP processing thus production of Aβ. All these results open new gateways towards the understanding of γ-secretase-associating proteins in APP processing and make inhibition of Rab21 a promising strategy for AD therapy.

Prototype of cavity for lepton acceleration in the SPS

CERN Multimedia

CERN PhotoLab

1982-01-01

The SPS was to be the injector for LEP and had to accelerate the electrons and positrons delivered by the PS. This is a prototype of a 200 MHz, single-cell, standing-wave, cavity for lepton acceleration in the SPS. On top of the cavity, at the back, is the tetrode amplifier, the tuning mechanism is leaning towards the viewer. See also 8103523 and Annual Report 1981, p.114.

Positron annihilation and Wheeler complexes in semiconductors

International Nuclear Information System (INIS)

Prokob'ev, E.P.

1995-01-01

The Wheeler complexes Ps-Ex (positronium-exciton) were studied. These complexes are formed during irradiation of semiconductors and ionic crystals with positrons at low temperatures under optical excitation by excitons. The binding energy of these and more complex entities preventing dissociation into Ps and Ex and/or Ex ± is at least 0.1 eV, and the lifetime for the two-photon self-annihilation is τ 2γ ∼ 5.02 x 10 -10 x c 3 s (x c is the phenomenological parameter of the effective-mass method). The estimation of lifetimes τ 2γ and τ 2γ t (the total lifetime of Ps-Ex complexes with account for positron annihilation on valence electrons) led to the conclusion that Ps-Ex complexes can be observed in a number of oxide semiconductors, in zinc sulfide, and in alkali halide crystals; however, it was difficult to observe such complexes in silicon, gallium arsenide, and other A 3 B 5 and A 2 B 6 semiconductors

Characterization of cucurbita maxima phloem serpin-1 (CmPS-1). A developmentally regulated elastase inhibitor.

Science.gov (United States)

Yoo, B C; Aoki, K; Xiang, Y; Campbell, L R; Hull, R J; Xoconostle-Cázares, B; Monzer, J; Lee, J Y; Ullman, D E; Lucas, W J

2000-11-10

We report on the molecular, biochemical, and functional characterization of Cucurbita maxima phloem serpin-1 (CmPS-1), a novel 42-kDa serine proteinase inhibitor that is developmentally regulated and has anti-elastase properties. CmPS-1 was purified to near homogeneity from C. maxima (pumpkin) phloem exudate and, based on microsequence analysis, the cDNA encoding CmPS-1 was cloned. The association rate constant (k(a)) of phloem-purified and recombinant His(6)-tagged CmPS-1 for elastase was 3.5 +/- 1.6 x 10(5) and 2.7 +/- 0.4 x 10(5) m(-)(1) s(-)(1), respectively. The fraction of complex-forming CmPS-1, X(inh), was estimated at 79%. CmPS-1 displayed no detectable inhibitory properties against chymotrypsin, trypsin, or thrombin. The elastase cleavage sites within the reactive center loop of CmPS-1 were determined to be Val(347)-Gly(348) and Val(350)-Ser(351) with a 3:2 molar ratio. In vivo feeding assays conducted with the piercing-sucking aphid, Myzus persicae, established a close correlation between the developmentally regulated increase in CmPS-1 within the phloem sap and the reduced ability of these insects to survive and reproduce on C. maxima. However, in vitro feeding experiments, using purified phloem CmPS-1, failed to demonstrate a direct effect on aphid survival. Likely roles of this novel phloem serpin in defense against insects/pathogens are discussed.

Psychometric properties of the OARSI/OMERACT osteoarthritis pain and functional impairment scales: ICOAP, KOOS-PS and HOOS-PS.

Science.gov (United States)

Ruyssen-Witrand, A; Fernandez-Lopez, C J; Gossec, L; Anract, P; Courpied, J P; Dougados, M

2011-01-01

To evaluate the psychometric properties of the OARSI-OMERACT questionnaires in comparison to the existing validated scales. Consecutive hip or knee osteoarthritis patients consulting in an orthopedic department were enrolled in the study. Data collected were pain using the Intermittent and Constant Osteoarthritis Pain (ICOAP), a Numeric Rating Scale (NRS), the Western Ontario McMaster Universities' Osteoarthritis Index (WOMAC) pain subscale, the Lequesne pain subscale; functional impairment using the Knee disability and Osteoarthritis Outcome Score-Physical Function Shortform (KOOS-PS), the Hip disability and Osteoarthritis Outcome Score-Physical Function Shortform (HOOS-PS), a NRS, the WOMAC function sub-scale, the Lequesne function subscale. Validity was assessed by calculating the Spearman's correlation coefficient between all the scales. Reliability was assessed in out-patients with stable disease comparing the data collected within 2 weeks using the intra-class correlation coefficient (ICC). Responsiveness was assessed on the data from hospitalised patients prior to and 12 weeks after a total joint replacement (TJR) using the standardised response mean. Three hundred patients (mean age=68 years, females=62%, hip OA=57%) were included. There was a moderate to good correlation between ICOAP, KOOS-PS, HOOS-PS and the WOMAC, NRS and Lequesne scales. Reliability of the ICOAP hip OA HOOS-PS and KOOS-PS was good (ICC range 0.80-0.81) whereas it was moderate for knee ICOAP (ICC=0.65). Responsiveness of the ICOAP, KOOS-PS and HOOS-PS 12 weeks after TJR was comparable to responsiveness of other scales (SRM range: 0.54-1.82). The psychometric properties of the ICOAP, KOOS-PS and HOOS-PS were comparable to those of the WOMAC, Lequesne and NRS.

GP pain management: what are the 'Ps' and 'As' of pain management?

Science.gov (United States)

Wan, Aston

2014-08-01

Pain is one common reason for clinical encounters in primary care. The complex nature of chronic pain syndromes can make assessment and management daunting at times. This article presents an easy scheme to help general practitioners efficiently assess, manage and review/follow up patients with chronic pain. The mnemonic presented for assessment is the '4Ps' (pain, other pathology/past medical history, performance/function and psychological/psychiatric status). For management, we can also use '4Ps' (physical, psychological, pharmacological and procedural) and for review there are the '6As' (activities, analgesia, adverse effects, aberrance behaviours, affects and adequate documentation).

Expectation values of the e+PsH system

International Nuclear Information System (INIS)

Zhang, J.-Y.; Mitroy, J.

2007-01-01

Close to converged energies and expectation values for e + PsH are computed using a ground-state wave function consisting of 1500 explicitly correlated Gaussians. The best estimate of the e + PsH ∞ energy was -0.810 254 hartrees, which has a binding energy of 0.021 057 hartrees against dissociation into e + +PsH. The 2γ annihilation rate was 2.7508x10 9 s -1 . Binding energies and annihilation rates are also given for the different finite-mass variants of e + PsH. Comparisons between expectation values for e + PsH and PsH provide compelling evidence that the e + PsH ground state can be regarded as consisting of a weakly bound positron orbiting the PsH ground state

D-wave resonances in three-body system Ps- with pure Coulomb and screened Coulomb (Yukawa) potentials

International Nuclear Information System (INIS)

Kar, S.; Ho, Y.K.

2009-01-01

We have investigated the doubly excited 1 D e resonance states of Ps - interacting with pure Coulomb and screened Coulomb (Yukawa) potentials employing highly correlated wave functions. For pure Coulomb interaction, in the framework of stabilization method and complex coordinate rotation method we have obtained two resonances below the n = 2 threshold of the Ps atom. For screened Coulomb interaction, we employ the stabilization method to extract resonance parameters. Resonance energies and widths for the 1 D e resonance states of Ps - for different screening parameter ranging from infinity (pure Coulomb case) to a small value are also reported. (author)

The Fluka Linebuilder and Element Database: Tools for Building Complex Models of Accelerators Beam Lines

CERN Document Server

Mereghetti, A; Cerutti, F; Versaci, R; Vlachoudis, V

2012-01-01

Extended FLUKA models of accelerator beam lines can be extremely complex: heavy to manipulate, poorly versatile and prone to mismatched positioning. We developed a framework capable of creating the FLUKA model of an arbitrary portion of a given accelerator, starting from the optics configuration and a few other information provided by the user. The framework includes a builder (LineBuilder), an element database and a series of configuration and analysis scripts. The LineBuilder is a Python program aimed at dynamically assembling complex FLUKA models of accelerator beam lines: positions, magnetic fields and scorings are automatically set up, and geometry details such as apertures of collimators, tilting and misalignment of elements, beam pipes and tunnel geometries can be entered at user’s will. The element database (FEDB) is a collection of detailed FLUKA geometry models of machine elements. This framework has been widely used for recent LHC and SPS beam-machine interaction studies at CERN, and led to a dra...

A fast, noniterative approach for accelerated high-temporal resolution cine-CMR using dynamically interleaved streak removal in the power-spectral encoded domain with low-pass filtering (DISPEL) and modulo-prime spokes (MoPS).

Science.gov (United States)

Kawaji, Keigo; Patel, Mita B; Cantrell, Charles G; Tanaka, Akiko; Marino, Marco; Tamura, Satoshi; Wang, Hui; Wang, Yi; Carroll, Timothy J; Ota, Takeyoshi; Patel, Amit R

2017-07-01

To introduce a pair of accelerated non-Cartesian acquisition principles that when combined, exploit the periodicity of k-space acquisition, and thereby enable acquisition of high-temporal cine Cardiac Magnetic Resonance (CMR). The mathematical formulation of a noniterative, undersampled non-Cartesian cine acquisition and reconstruction is presented. First, a low-pass filtering step that exploits streaking artifact redundancy is provided (i.e., Dynamically Interleaved Streak removal in the Power-spectrum Encoded domain with Low-pass filtering [DISPEL]). Next, an effective radial acquisition for the DISPEL approach that exploits the property of prime numbers is described (i.e., Modulo-Prime Spoke [MoPS]). Both DISPEL and MoPS are examined using numerical simulation of a digital heart phantom to show that high-temporal cine-CMR is feasible without removing physiologic motion vs aperiodic interleaving using Golden Angles. The combined high-temporal cine approach is next examined in 11 healthy subjects for a time-volume curve assessment of left ventricular systolic and diastolic performance vs conventional Cartesian cine-CMR reference. The DISPEL method was first shown using simulation under different streak cycles to allow separation of undersampled radial streaking artifacts from physiologic motion with a sufficiently frequent streak-cycle interval. Radial interleaving with MoPS is next shown to allow interleaves with pseudo-Golden-Angle variants, and be more compatible with DISPEL against irrational and nonperiodic rotation angles, including the Golden-Angle-derived rotations. In the in vivo data, the proposed method showed no statistical difference in the systolic performance, while diastolic parameters sensitive to the cine's temporal resolution were statistically significant (P cine). We demonstrate a high-temporal resolution cine-CMR using DISPEL and MoPS, whose streaking artifact was separated from physiologic motion. © 2017 American Association of Physicists

PS2004 Light-harvesting Systems Workshop

Energy Technology Data Exchange (ETDEWEB)

Blankenship, Robert E.

2005-01-01

This special issue of the international scientific research journal Photosynthesis Research consists of 25 original peer-reviewed contributions from participants in the PS 2004 Lisht-Harvesting Systems Workshop. This workshop was held from 26-29, 2004 at Hotel Le Chantecler, Sainte-Adele, Quebec, Canada. The workshop was a satellite meeting of the XIII International Congress on Photosynthesis held August 29-September 3, 2004 in Montreal, Canada. The workshope dealt with all types of photosynthetic antenna systems and types of organisms, including anoxygenic photosynthetic bacteria, cyanobacteria, algae and higher plants, as well as in vitro studies of isolated pigments. This collection of papers is a good representation of the highly interdisciplinary nature of modern research on photosynthetic antenna complexes, utilizing techniques of advanced spectroscopy, biochemistry, molecular biology, synthetic chemistry and structural determination to understand these diverse and elegant molecular complexes.

Electron pulse shaping in the FELIX RF accelerator

NARCIS (Netherlands)

Weits, H. H.; van der Geer, C. A. J.; Oepts, D.; van der Meer, A. F. G.

1999-01-01

The FELIX free-electron laser uses short pulses of relativistic electrons produced by an RF accelerator. The design target for the duration of these electron bunches was around 3 ps. In experiments we observed that the bunches emit coherently enhanced spontaneous emission (CSE) when they travel

Rejuvenation of the controls of the CERN PS/ISOLDE facility using industrial components

CERN Document Server

Allard, J.; Locci, F.; Mornacchi, G.

2001-01-01

In the context of the general consolidation of the CERN ISOLDE facility, a project has been started to upgrade the ISOLDE control system. We describe the new ISOLDE control system, emphasizing the systematic use of industrial components such as PLCs and field buses, their integration with the existing, VME based, CERN PS control system and their potential applicability to both existing and new controls problems at the CERN PS complex. We also discuss how to extend a PLC-based solution to the case where real-time response is an issue.

Sequence control of phase separation and dewetting in PS/PVME blend thin films by changing molecular weight of PS.

Science.gov (United States)

Xia, Tian; Qin, Yaping; Huang, Yajiang; Huang, Ting; Xu, Jianhui; Li, Youbing

2016-11-28

The morphology evolution mechanism of polystyrene (PS)/poly (vinyl methyl ether) (PVME) blend thin films with different PS molecular weights (M w ) was studied. It was found that the morphology evolution was closely related to the molecular weight asymmetry between PS and PVME. In the film where M w (PS) ≈ M w (PVME), dewetting happened at the interface between the bottom layer and substrate after SD phase separation. While in the film where M w (PS) > M w (PVME), dewetting happened at the interface between the middle PS/PVME blend layer and bottom PVME layer near the substrate prior to phase separation. The different sequences of phase separation and dewetting and different interface for dewetting occurrence were studied by regarding the competitive effects of viscoelasticity contrast between polymer components and preferential wetting between PVME and the substrate. The viscoelastic nature of the PS component played a crucial role in the sequence of phase separation and dewetting.

Proceedings of the workshop on 12 GeV PS experiments

International Nuclear Information System (INIS)

Kumagai, N.; Chiba, J.; Tsuru, T.; Yoshimura, Y.; Sasao, N.

1988-01-01

It is considered that in the physics using the KEK (National Laboratory for High Energy Physics) PS, the experiment using high intensity proton beam such as the experiment on nuclei with kaons and the research on rare decay becomes important in future, therefore, the improvement of accelerators and the construction of new beam channels and a new laboratory have been investigated. The request of budget has been made according to this plan, and it was approved in the revised budget for fiscal year 1987. It was decided to construct a new laboratory in the existing bubble chamber beam line, and move a part of beam lines to there. A first plan was made by a KEK group, and based on it, it becomes necessary to work out the best plan to be executed, considering the experimental plan and schedule of PS users. Also the plan of using the existing laboratories after the move of beam channels must be examined, therefore, the workshop was held on October 12 and 13, 1987, and more than 50 people took part in the discussion. In this book, the reports presented at that time are collected. (Kako, I.)

Subunit stoichiometry of the chloroplast photosystem I complex

International Nuclear Information System (INIS)

Bruce, B.D.; Malkin, R.

1988-01-01

A native photosystem I (PS I) complex and a PS I core complex depleted of antenna subunits has been isolated from the uniformly 14 C-labeled aquatic higher plant, Lemna. These complexes have been analyzed for their subunit stoichiometry by quantitative sodium dodecyl sulfate-polyacrylamide gel electrophoresis methods. The results for both preparations indicate that one copy of each high molecular mass subunit is present per PS I complex and that a single copy of most low molecular mass subunits is also present. These results suggest that iron-sulfur center X, an early PS I electron acceptor proposed to bind to the high molecular mass subunits, contains a single [4Fe-4S] cluster which is bound to a dimeric structure of high molecular mass subunits, each providing 2 cysteine residues to coordinate this cluster

Multiple purpose research complex on the basis of electron accelerators and terahertz free electron laser

International Nuclear Information System (INIS)

Kulipanov, G.N.

2009-01-01

In this report the basic positioning parameters of multiple purpose research complex are presented, the list of potential experiments and technological uses on the example of results received in the multiuser center of G.I. Budker Institut of nuclear physics Siberian department of the Russian Academy of Sciences is discussed. This research complex is directed on work in the big universities and nano technology centers. Electron accelerators is intended for development of electron-beam technologies different material modification, for production of nano powder, nano materials and solution of ecological tasks. In this work the project of multiple purpose research complex on the basis of new generation electron accelerator Il-14 and workable terahertz free electron laser is suggested. Terahertz free electron laser will be used for researches in the sphere of physics and chemistry, biology and medicine, nanotechnology engineering and different methods of nanodiagnostics.

A proof of principle experiment of laser wakefield accelerator

International Nuclear Information System (INIS)

Nakajima, K.; Enomoto, A.; Nakanishi, H.; Ogata, A.; Kato, Y.; Kitagawa, Y.; Mima, K.; Shiraga, H.; Yamakawa, K.; Downer, M.; Horton, W.; Newberger, B.; Tajima, T.

1992-01-01

Ultrashort super-intense lasers allow us to test a principle of the laser wakefield particle acceleration. The peak power of 30 TW and the pulse width of 1 ps produced by the Nd:glass laser system is capable of creating a highly-ionized plasma of a moderate density gas in an ultrafast time scale and generating a large amplitude plasma wave with the accelerating gradient of 2.5 GeV/m. Particle acceleration can be demonstrated by injecting a few MeV electrons emitted from a solid target by intense laser irradiation. (Author) 2 figs., 5 refs

Electron Spin Resonance studies on PS, PP and PS/PP blends under gamma irradiation

International Nuclear Information System (INIS)

Reyes, J.; Claro, M.; Albano, C.; Venezuela Central University, Caracas; Moronta, D.

2002-01-01

Complete text of publication follows. Electron Spin Resonance (ESR) studies on Polystyrene (PS), Polypropylene (PP) and their mixtures at compositions of 80/20 with and without a compatibilizer (SBS in block), 7.5 wt.%, irradiated with gamma rays from a Cobalt-60 source with a dose rate of 4.8 KGy/h at integral doses of radiation of 10, 25, 50, 60, 70, 400, 800 and 1300 KGy in the presence of air and at room temperature (RT) are reported. The dependence of resonance line width, Hpp; resonance line shapes K, and radical concentration, S, with the integral dose of irradiation is investigated. The nature of the free radicals after ten days of air storage is discussed. The free radical concentration, the double integral of the resonance line, S, has been estimated at room temperature, RT, for a group of single lines, characterized by the same giromagnetic, g, value by direct numerical double integration. In the samples studied no spectrum of 0 kGy of integral dose was observed. The concentration of radicals, S, observed when the integral radiation doses was increased, presents a maximum value in the PP samples at high doses (70-1300 kGy) and minimum values in the PS samples with the same doses. This shows that the PP degrades at a faster rate than the PS, owing to the presence of the bencenic ring in the latter. In the PS/PP mixtures studied with and without compatibilizer, the values of the radical concentration is found between the observed values in the homopolymers, being closer to the PS, which might imply that the presence of PS decays the degradation process of the PP in the mixture

Determination of Beam Intensity and Position in a Particle Accelerator

CERN Document Server

Kasprowicz, Grzegorz

2010-01-01

The Proton Synchrotron accelerator (PS), installed at CERN, although commissioned in 1959, still plays a central role in the production of beams for the Antiproton Decelerator, Super Proton Synchrotron, various experimental areas and for the Large Hadron Collider (LHC). The PS produces beams of different types of particles, mainly protons, but also various species of ions. Almost all these particle beams pass through the PS. The quality of the beams delivered to the LHC has a direct impact on the effective luminosity, and therefore the performance of the instrumentation of the PS is of great importance. The old trajec- tory and orbit measurement system of the PS dated back to 1988 and no longer fulfilled present day requirements. It used 40 beam position monitors (BPMs) and an analogue signal processing chain to acquire the trajectory of one single particle bunch out of many, over two consecutive turns at a maximum rate of once every 5ms. The BPMs were in good condition, however the electronics was aging and ...

Cs0.49NbPS6

Directory of Open Access Journals (Sweden)

Hoseop Yun

2011-01-01

Full Text Available The quaternary thiophosphate, Cs0.49NbPS6, caesium hexathioniobiophosphate(V, has been synthesized by the reactive halide flux method. The title compound is isotypic with Rb0.46TaPS6 and is made up of a bicapped trigonal–biprismatic [Nb2S12] unit and a tetrahedral [PS4] group. The [Nb2S12] units linked by the [PS4] tetrahedra form infinite chains, yielding a three-dimensional network with rather large van der Waals gaps along the c axis in which the disordered Cs+ ions reside. The electrons released by the Cs atoms are transferred to the pairwise niobium metal site and there are substantial intermetallic Nb—Nb bonding interactions. This leads to a significant decrease of the intermetallic distance in the title compound compared to that in TaPS6. The classical charge balance of the title compound may be represented as [Cs+]0.49[Nb4.51+][P5+][S2−]4[S22−].

AXEL-2016: Introduction to Particle Accelerators

CERN Multimedia

2016-01-01

AXEL-2016 is the latest in a yearly lecture series on particle accelerators given at CERN within the framework of the 2016 Technical Training Programme. As part of the BE department's Operation group’s shutdown lecture series, this general accelerator physics module has been offered since 2003 as a joint venture between the BE department and the Technical Training team and is open to the wider CERN community.    The lecturer is Rende Steerenberg, deputy leader of the Operation group and PS section leader. Programme: basic mathematics; transverse optics; lattice calculations; resonances; longitudinal motion; transfer lines, injection and ejection; longitudinal and transverse beam instabilities; colliders. A detailed programme is available on the AXEL-2016 webpage. Target audience: designed for technicians who are operating an accelerator or whose work is closely linked to accelerators, but also open to technicians, engineers and physicists interested i...

Kinetic modeling of electron transfer reactions in photosystem I complexes of various structures with substituted quinone acceptors.

Science.gov (United States)

Milanovsky, Georgy E; Petrova, Anastasia A; Cherepanov, Dmitry A; Semenov, Alexey Yu

2017-09-01

The reduction kinetics of the photo-oxidized primary electron donor P 700 in photosystem I (PS I) complexes from cyanobacteria Synechocystis sp. PCC 6803 were analyzed within the kinetic model, which considers electron transfer (ET) reactions between P 700 , secondary quinone acceptor A 1 , iron-sulfur clusters and external electron donor and acceptors - methylviologen (MV), 2,3-dichloro-naphthoquinone (Cl 2 NQ) and oxygen. PS I complexes containing various quinones in the A 1 -binding site (phylloquinone PhQ, plastoquinone-9 PQ and Cl 2 NQ) as well as F X -core complexes, depleted of terminal iron-sulfur F A /F B clusters, were studied. The acceleration of charge recombination in F X -core complexes by PhQ/PQ substitution indicates that backward ET from the iron-sulfur clusters involves quinone in the A 1 -binding site. The kinetic parameters of ET reactions were obtained by global fitting of the P 700 + reduction with the kinetic model. The free energy gap ΔG 0 between F X and F A /F B clusters was estimated as -130 meV. The driving force of ET from A 1 to F X was determined as -50 and -220 meV for PhQ in the A and B cofactor branches, respectively. For PQ in A 1A -site, this reaction was found to be endergonic (ΔG 0  = +75 meV). The interaction of PS I with external acceptors was quantitatively described in terms of Michaelis-Menten kinetics. The second-order rate constants of ET from F A /F B , F X and Cl 2 NQ in the A 1 -site of PS I to external acceptors were estimated. The side production of superoxide radical in the A 1 -site by oxygen reduction via the Mehler reaction might comprise ≥0.3% of the total electron flow in PS I.

Visualization of complex DNA damage along accelerated ions tracks

Science.gov (United States)

Kulikova, Elena; Boreyko, Alla; Bulanova, Tatiana; Ježková, Lucie; Zadneprianetc, Mariia; Smirnova, Elena

2018-04-01

The most deleterious DNA lesions induced by ionizing radiation are clustered DNA double-strand breaks (DSB). Clustered or complex DNA damage is a combination of a few simple lesions (single-strand breaks, base damage etc.) within one or two DNA helix turns. It is known that yield of complex DNA lesions increases with increasing linear energy transfer (LET) of radiation. For investigation of the induction and repair of complex DNA lesions, human fibroblasts were irradiated with high-LET 15N ions (LET = 183.3 keV/μm, E = 13MeV/n) and low-LET 60Co γ-rays (LET ≈ 0.3 keV/μm) radiation. DNA DSBs (γH2AX and 53BP1) and base damage (OGG1) markers were visualized by immunofluorecence staining and high-resolution microscopy. The obtained results showed slower repair kinetics of induced DSBs in cells irradiated with accelerated ions compared to 60Co γ-rays, indicating induction of more complex DNA damage. Confirming previous assumptions, detailed 3D analysis of γH2AX/53BP1 foci in 15N ions tracks revealed more complicated structure of the foci in contrast to γ-rays. It was shown that proteins 53BP1 and OGG1 involved in repair of DNA DSBs and modified bases, respectively, were colocalized in tracks of 15N ions and thus represented clustered DNA DSBs.

SPS and PS Experiments Committee

CERN Multimedia

CERN. Geneva

2004-01-01

OPEN SESSION: 09:00 Status report of NA58 / COMPASS: A. Magnon 09:40 Status report of PS212 / DIRAC: L. Tausher 10:10 PS212 / DIRAC Addendum: L. Nemenov CLOSED SESSION on Tuesday, 27 April 2004 after the open session, Main Building, 6th floor conference room

Psühhodramaatikud annavad Pärnus eksami

Index Scriptorium Estoniae

2008-01-01

29. maist kuni 1. juunini kestab Pärnus psühhodraama konverents "Geeniuste kohtumine", kus rahvusvahelise koolituse läbinud annavad eksami. Ruuda Palmquist on psühhodraama kui teadusharu rajajaid Eestis. Pärnus on kohal Rootsi Moreno Instituudi juhataja, psühhodraama lavastaja Marc Treadwell

Preparation of PLLA/PMMA and PLLA/PS binary blend nanoparticles by incorporation of PLLA in methyl methacrylate or styrene miniemulsion homopolymerization

Directory of Open Access Journals (Sweden)

Luana Becker Peres

2015-02-01

Full Text Available Miniemulsion homopolymerization reactions of methyl methacrylate (MMA and styrene (STY using poly(L-lactide as co-stabilizer were carried out in order to prepare poly(L-lactide/poly(methyl methacrylate (PLLA/PMMA and poly(L-lactide/polystyrene (PLLA/PS binary blend nanoparticles. The effect of PLLA concentration on methyl methacrylate (MMA and styrene (STY homopolymerization reactions was evaluated. It was found that the incorporation of PLLA resulted on acceleration of MMA and STY homopolymerization reactions and led to a molar mass increase of up to 70% for PS in PLLA/PS blend nanoparticles in relation to those prepared without PLLA, which can be attributed to an increase of reaction loci viscosity (gel effect. PLLA also acted as an efficient co-stabilizer, since it was able to retard diffusional degradation of droplets when no other kind of co-stabilizer was used. Two isolated Tgs were found in both PLLA/PMMA and PLLA/PS blend nanoparticles which can be associated to blend immiscibility. TEM images corroborate these results, suggesting that immiscible PLLA/PMMA and PLLA/PS blend nanoparticles could be formed with two segregated phases and core-shell morphology.

LEADIR-PS: providing unprecedented SMR safety and economics

Energy Technology Data Exchange (ETDEWEB)

Hart, R.S., E-mail: N2i2@xplornet.ca [Northern Nuclear Industries Incorporated, Cambridge, ON (Canada)

2015-07-01

Northern Nuclear Industries Incorporated (N{sup 2} I{sup 2}) is developing Small Modular Reactors (SMRs) called LEADIR-PS, an acronym for LEAD-cooled Integral Reactor-Passively Safe. LEADIR-PS integrates proven technologies including TRISO fuel, Pebble Bed core and graphite moderator, with molten lead coolant in an integral pool type reactor configuration to achieve unprecedented safety and economics. Plants under development are LEADIR-PS30, producing 30 MWth, LEADIR-PS100 producing 100 MWth and LEADIR-PS300 producing 300 MWth that are focused on serving the energy demands of areas with a small electrical grid and/or process heat applications. A plant consisting of six LEADIR-PS300 reactor modules serving a common turbine-generator, called the LEADIR-PS Six-Pack, is focused on serving areas with higher energy demands and a robust electricity grid. The Gen{sup +} I LEADIR-PS plants are inherently/passively safe. There is no potential for a Loss Of Coolant Accident, a reactivity transient without shutdown, a loss of heat sink, or hydrogen generation. No active systems or operator actions are required to assure safety. The unprecedented safety of LEADIR-PS reactors avoids large exclusion radius and demanding evacuation plan requirements. LEADIR-PS, with steam conditions of 370 {sup o}C and 12 MPa can serve over 85% of the world's non-transportation process heat demands. In Canada, the electricity and process heat demands, ranging from those of remote communities and the oil sands to densely populated areas can be served by LEADIR-PS. (author)

Platform strategy for complex products and systems

NARCIS (Netherlands)

Alblas, A.A.

2011-01-01

The thesis of Alex Alblas presents a design reuse strategy for firms producing complex products and systems (CoPS). Examples of CoPS include industrial machinery, oil-rigs, electrical power distribution systems, integrated mail processing systems and printing press machinery. CoPS firms are

The histone acetyltransferase PsGcn5 mediates oxidative stress responses and is required for full virulence of Phytophthora sojae.

Science.gov (United States)

Zhao, Wei; Wang, Tao; Liu, Shusen; Chen, Qingqing; Qi, Rende

2015-10-01

In eukaryotic organisms, histone acetyltransferase complexes are coactivators that are important for transcriptional activation by modifying chromatin. In this study, a gene (PsGcn5) from Phytophthora sojae encoding a histone acetyltransferase was identified as a homolog of one component of the histone acetyltransferase complex from yeasts to mammals. PsGcn5 was constitutively expressed in each stage tested, but had a slightly higher expression in sporulating hyphae and 3 h after infection. PsGcn5-silenced mutants were generated using polyethylene glycol-mediated protoplast stable transformation. These mutants had normal development, but compared to wild type strains they had higher sensitivity to hydrogen peroxide (H2O2) and significantly reduced virulence in soybean. Diaminobenzidine staining revealed an accumulation of H2O2 around the infection sites of PsGcn5-silenced mutants but not for wild type strains. Inhibition of the plant NADPH oxidase by diphenyleneiodonium prevented host-derived H2O2 accumulation in soybean cells and restored infectious hyphal growth of the mutants. Thus, we concluded that PsGcn5 is important for growth under conditions of oxidative stress and contributes to the full virulence of P. sojae by suppressing the host-derived reactive oxygen species. Copyright © 2015 Elsevier Ltd. All rights reserved.

Two-year survival rates of anti-TNF-α therapy in psoriatic arthritis (PsA) patients with either polyarticular or oligoarticular PsA.

Science.gov (United States)

Iannone, F; Lopriore, S; Bucci, R; Scioscia, C; Anelli, M G; Notarnicola, A; Lapadula, G

2015-05-01

To evaluate the 2-year drug survival rates of the tumour necrosis factor (TNF)-α blockers adalimumab, etanercept, and infliximab in psoriatic arthritis (PsA) patients with either oligoarticular (oligo-PsA) or polyarticular PsA (poly-PsA). We studied a prospective cohort of 328 PsA patients with peripheral arthritis (213 with poly-PsA and 115 with oligo-PsA), beginning their first ever anti-TNF-α treatment with adalimumab, etanercept, or infliximab. The aim of the study was to evaluate the drug survival rates and possible baseline predictors at 2 years. After 24 months, persistence in therapy with the first anti-TNF-α blocker was not statistically different in the oligo-PsA (70.4%) and poly-PsA (65.7%) subsets. Predictors of drug discontinuation were female sex [hazard ratio (HR) 1.63, 95% confidence interval (CI) 1.00-2.68, p = 0.04] and starting the therapy in years 2003-8 (HR 0.51, 95% CI 0.33-0.80, p = 0.003). In poly-PsA, the persistence of etanercept (68.3%) was significantly higher than that of adalimumab (51.9%, p = 0.01), whereas in oligo-PsA no significant difference was detected. In poly-PsA, the period 2003-8 was a negative predictor (HR 0.36, 95% CI 0.21-0.62, p = 0.0001) whereas in oligo-PsA female gender was a positive predictor of drug discontinuation (HR 2.08, 95% CI 1.02-4.24, p = 0.04). With regard to clinical outcomes, the best responses in terms of European League Against Rheumatism (EULAR) 'good' response or Disease Activity Score (DAS28) remission, crude or adjusted according to the LUND Efficacy indeX (LUNDEX), were seen in patients on etanercept or infliximab. Our study provides some evidence that anti-TNF-α drugs may perform differently in PsA, and that the analysis of clinical disease subsets may improve our knowledge and promote better management of PsA.

Updating the Psoriatic Arthritis (PsA) Core Domain Set: A Report from the PsA Workshop at OMERACT 2016.

Science.gov (United States)

Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J; Callis Duffin, Kristina; Elmamoun, Musaab; Tillett, William; Campbell, Willemina; FitzGerald, Oliver; Gladman, Dafna D; Goel, Niti; Gossec, Laure; Hoejgaard, Pil; Leung, Ying Ying; Lindsay, Chris; Strand, Vibeke; van der Heijde, Désirée M; Shea, Bev; Christensen, Robin; Coates, Laura; Eder, Lihi; McHugh, Neil; Kalyoncu, Umut; Steinkoenig, Ingrid; Ogdie, Alexis

2017-10-01

To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants. We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted 24 focus groups with 130 patients from 7 countries representing 5 continents to identify patient domains. We achieved consensus through 2 rounds of separate surveys with 50 patients and 75 physicians, and a nominal group technique meeting with 12 patients and 12 physicians. We conducted a workshop and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA Core Domain Set endorsed with 90% agreement by OMERACT 2016 participants included musculoskeletal disease activity, skin disease activity, fatigue, pain, patient's global assessment, physical function, health-related quality of life, and systemic inflammation, which were recommended for all RCT and LOS. These were important, but not required in all RCT and LOS: economic cost, emotional well-being, participation, and structural damage. Independence, sleep, stiffness, and treatment burden were on the research agenda. The updated PsA Core Domain Set was endorsed at OMERACT 2016. Next steps for the PsA working group include evaluation of PsA outcome measures and development of a PsA Core Outcome Measurement Set.

Testing and interfacing intelligent power supplies for the Los Alamos National Laboratory Accelerator Complex

International Nuclear Information System (INIS)

Sturrock, J.C.; Cohen, S.; Weintraub, B.L.; Hayden, D.J.; Archuleta, S.F.

1992-01-01

New high-current, high-precision microprocessor-controlled power supplies, built by Alpha Scientific Electronics of Hayward, CA, have been installed at the Los Alamos National Laboratory Accelerator Complex. Each unit has sophisticated microprocessor control on-board and communicates via RS-422 (serial communications). The units use a high level ASCII-based control protocol. Performance tests were conducted to verify adherence to specification and to ascertain ultimate long-term stability. The ''front-end'' software used by the accelerator control system has been written to accommodate these new devices. The supplies are interfaced to the control system through a terminal server port connected to the site-wide ediernet backbone. Test design and results as well as details of the software implementation for the analog and digital control of the supplies through the accelerator control system are presented

A portable accelerator control toolkit

Energy Technology Data Exchange (ETDEWEB)

Watson, W.A. III

1997-06-01

In recent years, the expense of creating good control software has led to a number of collaborative efforts among laboratories to share this cost. The EPICS collaboration is a particularly successful example of this trend. More recently another collaborative effort has addressed the need for sophisticated high level software, including model driven accelerator controls. This work builds upon the CDEV (Common DEVice) software framework, which provides a generic abstraction of a control system, and maps that abstraction onto a number of site-specific control systems including EPICS, the SLAC control system, CERN/PS and others. In principle, it is now possible to create portable accelerator control applications which have no knowledge of the underlying and site-specific control system. Applications based on CDEV now provide a growing suite of tools for accelerator operations, including general purpose displays, an on-line accelerator model, beamline steering, machine status displays incorporating both hardware and model information (such as beam positions overlaid with beta functions) and more. A survey of CDEV compatible portable applications will be presented, as well as plans for future development.

A portable accelerator control toolkit

International Nuclear Information System (INIS)

Watson, W.A. III.

1997-01-01

In recent years, the expense of creating good control software has led to a number of collaborative efforts among laboratories to share this cost. The EPICS collaboration is a particularly successful example of this trend. More recently another collaborative effort has addressed the need for sophisticated high level software, including model driven accelerator controls. This work builds upon the CDEV (Common DEVice) software framework, which provides a generic abstraction of a control system, and maps that abstraction onto a number of site-specific control systems including EPICS, the SLAC control system, CERN/PS and others. In principle, it is now possible to create portable accelerator control applications which have no knowledge of the underlying and site-specific control system. Applications based on CDEV now provide a growing suite of tools for accelerator operations, including general purpose displays, an on-line accelerator model, beamline steering, machine status displays incorporating both hardware and model information (such as beam positions overlaid with beta functions) and more. A survey of CDEV compatible portable applications will be presented, as well as plans for future development

Heavy ion acceleration strategies in the AGS accelerator complex -- 1994 Status report

International Nuclear Information System (INIS)

Ahrens, L.A.; Benjamin, J.; Blaskiewicz, M.

1995-01-01

The strategies invoked to satisfy the injected beam specifications for the Brookhaven Relativistic Heavy Ion Collider (RHIC) continue to evolve, in the context of the yearly AGS fixed target heavy ion physics runs. The primary challenge is simply producing the required intensity. The acceleration flexibility available particularly in the Booster main magnet power supply and rf accelerating systems, together with variations in the charge state delivered from the Tandem van de Graaff, and accommodation by the AGS main magnet and rf systems allow the possibility for a wide range of options. The yearly physics run provides the opportunity for exploration of these options with the resulting significant evolution in the acceleration plan. This was particularly true in 1994 with strategies involving three different charge states and low and high acceleration rates employed in the Booster. The present status of this work will be presented

Temperature dependence of o-Ps annihilation lifetime in non-uniform cylindrical pores in comparison with ETE model

Energy Technology Data Exchange (ETDEWEB)

Khaghani, Morteza, E-mail: m.khaghani@pgs.usb.ac.ir; Mehmandoost-Khajeh-Dad, Ali Akbar, E-mail: mehmandoost@phys.usb.ac.ir

2017-04-01

Highlights: • Using the well known multi-physics program COMSOL calculating o-Ps annihilation lifetime in complex geometries. • Investigation of shape non-uniformity of cylindrical pores on o-Ps annihilation lifetime. • Verifying temperature dependency of o-Ps lifetime in non-uniform cylindrical pores. • Suggesting PALS at low temperature as a method to verify pore uniformity in porous material. - Abstract: Ortho-positronium (o-Ps) annihilation lifetime was calculated in non-uniform cylinder-shaped pores by solving Schrodinger equation using a well-known multi-physics program called COMSOL. The o-Ps annihilation lifetime variation in terms of temperature was calculated on the basis of ETE model via a numerical method. The COMSOL simulations indicate that as long as the pore is uniform cylinder-shaped, the results agree with those of two-dimensional ETE model, whereas deformations in the cylinder shape (indentation or protrusion) change the temperature behavior of ETE model and, thereby, higher values are predicted for o-Ps lifetime in the pore at lower temperatures. The geometry of the non-uniform cylinder-shaped pores, which is accompanied by empirical evidence, can be used for the analysis of empirical results obtained from positron lifetime spectroscopy in different temperatures.

iPS-Cinderella Story in Cell Biology

Directory of Open Access Journals (Sweden)

Editorial

2010-01-01

Full Text Available As we step through the frontiers of modern Science, we are all witnesses to the Cinderella story repeating itself in the form of the iPS. The process of re-programming adult somatic cells to derive Induced Pluripotent stem cells (iPS with the wand of transcription factors and then differentiating them back to adult somatic cells resembles the transformation of Cinderella from a Cinder girl to princess and back to a Cinder girl after the ball; but the iPS-Cinderella is the most fascinating thing ever in cell biology!From the day iPS first made its headlines when it was first produced by Shinya Yamanaka at Kyoto University in Japan, Stem Cell scientists all over the world are re- doing their experiments so far done using other sources like embryonic and adult Stem cells with the iPS cells exploring their potential to the fullest. A Stem Cell science news page without this magic word of iPS is difficult to imagine these days and Scientists have been successful in growing most of the adult Cell types from iPS cells.iPS cells was the key to solve the problems of Immune rejection and Immunosupression required when using other allogeneic Stem cell types which had baffled scientists previously. But the issues raised by scientists about the use of viruses and Oncogenes in producing iPS cells were made groundless when scientists in February 2008 published the discovery of a technique that could remove oncogenes after the induction of pluripotency and now it is possible to induce pluripotency using plasmid transfection, piggyback transposon system and piggyback transposon system combined with a non viral vector system. The word of the day is pIPS which are protein-induced Pluripotent stem cells which are iPS cells that were generated without any genetic alteration of the adult cell. This research by the group of Sheng Ding in La Jolla, California made public in April 2009 showed that the generation of poly-arginine anchors was sufficient to induce

Nanostructured silicate substituted calcium phosphate (NanoSiCaPs) nanoparticles — Efficient calcium phosphate based non-viral gene delivery systems

Energy Technology Data Exchange (ETDEWEB)

Shekhar, Sudhanshu [Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Center for Complex Engineered Multifunctional Materials, University of Pittsburgh, Pittsburgh, PA 15261 (United States); McGowan Institute of Regenerative Medicine, University of Pittsburgh, PA 15261 (United States); Roy, Abhijit; Hong, Daeho [Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Kumta, Prashant N., E-mail: pkumta@pitt.edu [Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Center for Complex Engineered Multifunctional Materials, University of Pittsburgh, Pittsburgh, PA 15261 (United States); McGowan Institute of Regenerative Medicine, University of Pittsburgh, PA 15261 (United States)

2016-12-01

Nanostructured ceramic particles, particularly, nanoparticles of calcium phosphate (CaP) remain an attractive option among the various types of non-viral gene delivery vectors studied because of their safety, biocompatibility, biodegradability, and ease of handling as well as their adsorptive capacity for DNA. We have accordingly developed an enhanced version of nanostructured calcium phosphates (NanoCaPs), by substituting known amounts of silicate for phosphate in the hydroxyapatite (HA) lattice (NanoSiCaPs). Results indicate that in addition to the excellent transfection levels exhibited by un-substituted NanoCaPs alone in vitro, an additional 20–50% increase in transfection is observed for NanoCaPs containing 8.3–50 mol% silicate aptly called NanoSiCaPs, owing to its rapid dissolution properties enabling nanoparticles escaping the lysosomal degradation. However, high silicate substitution (> 50 mol%) resulted in a drastic decline in transfection as the synthesized NanoCaPs deviated far from the characteristic hydroxyapatite phase formed as evidenced by the materials characterization results. - Highlights: • Successful demonstration of nanostructured NanoSiCaPs formation • Demonstration of superior transfection of NanoSiCaPs contrasted to NanoCaPs • Silicate substitution leads to smaller aggregates of nanoparticle complexes. • Enhanced dissolution of NanoSiCaPs demonstrated • Faster NanoSiCaPs dissolution leads to escape of pDNA from lysosomal degradation.

Manufacturing aspects of the new Pole Face correcting coils for the PS main magnets

CERN Document Server

Bodart, D

2011-01-01

This document reports about the Pole Face Winding (PFW) installed in the Main Magnets of the PS accelerator. Composed by sets of 4 and installed on every magnet, they are made of copper conductors and installed directly on the poles of the magnets. Their role is to compensate the saturation effect of the pole shape of the magnet yoke and compensate the eddy current in the vacuum chambers. Their manufacturing has evolved over the years, the dedicated fabrication process and requirements are explained in this document.

Complex workplace radiation fields at European high-energy accelerators and thermonuclear fusion facilities

CERN Document Server

Bilski, P; D'Errico, F; Esposito, A; Fehrenbacher, G; Fernàndez, F; Fuchs, A; Golnik, N; Lacoste, V; Leuschner, A; Sandri, S; Silari, M; Spurny, F; Wiegel, B; Wright, P

2006-01-01

This report outlines the research needs and research activities within Europe to develop new and improved methods and techniques for the characterization of complex radiation fields at workplaces around high-energy accelerators and the next generation of thermonuclear fusion facilities under the auspices of the COordinated Network for RAdiation Dosimetry (CONRAD) project funded by the European Commission.

The electron accelerator for the AWAKE experiment at CERN

Energy Technology Data Exchange (ETDEWEB)

Pepitone, K., E-mail: kevin.pepitone@cern.ch [CERN, Geneva (Switzerland); Doebert, S., E-mail: steffen.doebert@cern.ch [CERN, Geneva (Switzerland); Burt, G. [The University of Lancaster, Lancaster (United Kingdom); Chevallay, E.; Chritin, N.; Delory, C.; Fedosseev, V.; Hessler, Ch.; McMonagle, G. [CERN, Geneva (Switzerland); Mete, O. [The University of Manchester, Manchester (United Kingdom); Verzilov, V. [Triumf, Vancouver (Canada); Apsimon, R. [The University of Lancaster, Lancaster (United Kingdom)

2016-09-01

The AWAKE collaboration prepares a proton driven plasma wakefield acceleration experiment using the SPS beam at CERN. A long proton bunch extracted from the SPS interacts with a high power laser and a 10 m long rubidium vapour plasma cell to create strong wakefields allowing sustained electron acceleration. The electron bunch to probe these wakefields is supplied by a 20 MeV electron accelerator. The electron accelerator consists of an RF-gun and a short booster structure. This electron source should provide beams with intensities between 0.1 and 1 nC, bunch lengths between 0.3 and 3 ps and an emittance of the order of 2 mm mrad. The wide range of parameters should cope with the uncertainties and future prospects of the planned experiments. The layout of the electron accelerator, its instrumentation and beam dynamics simulations are presented.

Feasibility study of a 2 GeV superconducting $H^{-}$ linac as injector for the CERN PS

CERN Document Server

Garoby, R; Hill, C E; Lombardi, A M; Ostroumov, P N; Tessier, J M; Vretenar, Maurizio

1998-01-01

This preliminary feasibility study is based on the availability of the CERN LEP2 superconducting RF system after LEP de-commissioning. The option that is explored is to use this system as part of a high energy H- linac injecting at 2 GeV into the CERN PS, with the aim of reliably providing at its output twice the presently foreseen transverse beam brightness at the ultimate intensity envisaged for LHC. This requires the linac to be pulsed at the PS repetition rate of 0.8 Hz with a mean beam current of 10 mA which is sufficient for filling the PS in 240 ms (i.e. about 100 turns) with the ultimate intensity foreseen for injection for the LHC. The linac is composed of two RFQs with a chopping section, a room temperature DTL, a superconducting section with reduced beta cavities up to 1 GeV, and a section of LEP2 cavities up to 2 GeV. This study deals, in particular, with the problems inherent in H- acceleration up to high energy and in the pulsed operation of SC cavities. Means for compensating microphonic vibrat...

Dual-harmonic auto voltage control for the rapid cycling synchrotron of the Japan Proton Accelerator Research Complex

Directory of Open Access Journals (Sweden)

Fumihiko Tamura

2008-07-01

Full Text Available The dual-harmonic operation, in which the accelerating cavities are driven by the superposition of the fundamental and the second harmonic rf voltage, is useful for acceleration of the ultrahigh intensity proton beam in the rapid cycling synchrotron (RCS of Japan Proton Accelerator Research Complex (J-PARC. However, the precise and fast voltage control of the harmonics is necessary to realize the dual-harmonic acceleration. We developed the dual-harmonic auto voltage control system for the J-PARC RCS. We describe details of the design and the implementation. Various tests of the system are performed with the RCS rf system. Also, a preliminary beam test has been done. We report the test results.

Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells.

Science.gov (United States)

Kannappan, Ramaswamy; Mattapally, Saidulu; Wagle, Pooja A; Zhang, Jianyi

2018-05-18

The role of p53 transactivation domain (p53-TAD), a multifunctional and dynamic domain, on DNA repair and retaining DNA integrity in human iPS cells has never been studied. p53-TAD was knocked out in iPS cells using CRISPR/Cas9 and was confirmed by DNA sequencing. p53-TAD KO cells were characterized by: accelerated proliferation, decreased population doubling time, and unaltered Bcl2, BBC3, IGF1R, Bax and altered Mdm2, p21, and PIDD transcripts expression. In p53-TAD KO cells p53 regulated DNA repair proteins XPA, DNA polH and DDB2 expression were found to be reduced compared to p53-WT cells. Exposure to low dose of doxorubicin (Doxo) induced similar DNA damage and DNA damage response (DDR) measured by RAD50 and MRE11 expression, Checkpoint kinase 2 activation and γH2A.X recruitment at DNA strand breaks in both the cell groups indicating silencing p53-TAD do not affect DDR mechanism upstream of p53. Following removal of Doxo p53-WT hiPS cells underwent DNA repair, corrected their damaged DNA and restored DNA integrity. Conversely, p53-TAD KO hiPS cells did not undergo complete DNA repair and failed to restore DNA integrity. More importantly continuous culture of p53-TAD KO hiPS cells underwent G2/M cell cycle arrest and expressed cellular senescent marker p16 INK4a . Our data clearly shows that silencing transactivation domain of p53 did not affect DDR but affected the DNA repair process implying the crucial role of p53 transactivation domain in maintaining DNA integrity. Therefore, activating p53-TAD domain using small molecules may promote DNA repair and integrity of cells and prevent senescence.

Complexity analysis of accelerated MCMC methods for Bayesian inversion

International Nuclear Information System (INIS)

Hoang, Viet Ha; Schwab, Christoph; Stuart, Andrew M

2013-01-01

approximation methods used, in order for the accelerations of MCMC resulting from these strategies to lead to complexity reductions over ‘plain’ MCMC algorithms for the Bayesian inversion of PDEs. (paper)

New Control Structure of the 10 MHz RF System in the CERN PS

CERN Document Server

Damerau, H

2013-01-01

The 10MHz cavities comprise the main RF system in the CERN PS and the only one that allows acceleration. In total 11 tunable cavities (10 operational and a hot spare, grouped into 3+1 tuning groups and up to presently 6 voltage program groups) are distributed all around the circumference of the PS ring. Next to the RF drive signal each of the cavities is controlled by a voltage program and timing pulses to open and close the relays to short-circuit the cavity gaps. These control signals are presently generated by a dedicated hardware matrix. It translates voltage functions and relay timing pulses per cavity group into functions and timings per cavity. However, due to its central position in the RF beam control system, the dedicated hardware matrix can cause significant downtime in case of a major hardware failure. Instead of upgrading the existing obsolete hardware, this note suggests a replacement by standard controls hardware and dedicated application software. Thanks to advanced software concepts like “M...

Positron annihilation and Wheeler complexes in semiconductors

International Nuclear Information System (INIS)

Prokop'ev, E.P.

1995-01-01

Properties of Ps-Ex (positron-exciton) complex nature Wheeler complexes that may be formed at irradiation of semiconductors and ion crystals by positrons at low temperature under conditions of optical excitation by excitons are studied. Binding energy of similar and more complex systems regarding decomposition in Ps and Ex and/or Ex ± exceeds, at least, 0.1 eV, while lifetime regarding biquantum-self-annihilation constitutes τ 2γ ∼5.02x10 - 10 κ c 3 c (κ c -phenomenological parameter of the effective mass method). The lifetime estimations enabled to conclude that Ps-Ex complexes may be detected in some oxide semiconductors, in zinc sulfide, as well as, in alkaline-haloid crystals. At the same time, in silicon, gallium arsenide and in other semiconductors of A 3 B 5 and A 2 B 6 it is highly improbable to observe these complexes. 27 refs

Accelerated Biofluid Filling in Complex Microfluidic Networks by Vacuum-Pressure Accelerated Movement (V-PAM).

Science.gov (United States)

Yu, Zeta Tak For; Cheung, Mei Ki; Liu, Shirley Xiaosu; Fu, Jianping

2016-09-01

Rapid fluid transport and exchange are critical operations involved in many microfluidic applications. However, conventional mechanisms used for driving fluid transport in microfluidics, such as micropumping and high pressure, can be inaccurate and difficult for implementation for integrated microfluidics containing control components and closed compartments. Here, a technology has been developed termed Vacuum-Pressure Accelerated Movement (V-PAM) capable of significantly enhancing biofluid transport in complex microfluidic environments containing dead-end channels and closed chambers. Operation of the V-PAM entails a pressurized fluid loading into microfluidic channels where gas confined inside can rapidly be dissipated through permeation through a thin, gas-permeable membrane sandwiched between microfluidic channels and a network of vacuum channels. Effects of different structural and operational parameters of the V-PAM for promoting fluid filling in microfluidic environments have been studied systematically. This work further demonstrates the applicability of V-PAM for rapid filling of temperature-sensitive hydrogels and unprocessed whole blood into complex irregular microfluidic networks such as microfluidic leaf venation patterns and blood circulatory systems. Together, the V-PAM technology provides a promising generic microfluidic tool for advanced fluid control and transport in integrated microfluidics for different microfluidic diagnosis, organs-on-chips, and biomimetic studies. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Complex envelope control of pulsed accelerating fields in superconducting cavities

CERN Document Server

Czarski, T

2010-01-01

A digital control system for superconducting cavities of a linear accelerator is presented in this work. FPGA (Field Programmable Gate Arrays) based controller, managed by MATLAB, was developed to investigate a novel firmware implementation. The LLRF - Low Level Radio Frequency system for FLASH project in DESY is introduced. Essential modeling of a cavity resonator with signal and power analysis is considered as a key approach to the control methods. An electrical model is represented by the non-stationary state space equation for the complex envelope of the cavity voltage driven by the current generator and the beam loading. The electromechanical model of the superconducting cavity resonator including the Lorentz force detuning has been developed for a simulation purpose. The digital signal processing is proposed for the field vector detection. The field vector sum control is considered for multiple cavities driven by one klystron. An algebraic, complex domain model is proposed for the system analysis. The c...

Automated installations for reeling up of superconducting magnet windings of the accelerating-storage complex

International Nuclear Information System (INIS)

Dolzhenkov, V.I.; Elistratov, V.V.; Kuznetsov, Yu.V.; Petrov, V.B.; Popov, V.V.; Savel'ev, A.V.; Sokolov, B.V.; Sytnik, V.V.; Tarakanov, N.M.; Ustinov, E.A.

1992-01-01

An automated facility for reeling up the windings of model and full-scale superconducting magnets of the accelerating-storage complex is described. The control system monitors superconducting cable tension, transport carriage linear velocity and some other parameters. Maximum length of the winded coils is 6 m. Cable tension stability - 5%

Functional characterization of calcineurin homologs PsCNA1/PsCNB1 in Puccinia striiformis f. sp. tritici using a host-induced RNAi system.

Directory of Open Access Journals (Sweden)

Hong Zhang

Full Text Available Calcineurin plays a key role in morphogenesis, pathogenesis and drug resistance in most fungi. However, the function of calcineurin genes in Puccinia striiformis f. sp. tritici (Pst is unclear. We identified and characterized the calcineurin genes PsCNA1 and PsCNB1 in Pst. Phylogenetic analyses indicate that PsCNA1 and PsCNB1 form a calcium/calmodulin regulated protein phosphatase belonging to the calcineurin heterodimers composed of subunits A and B. Quantitative RT-PCR analyses revealed that both PsCNA1 and PsCNB1 expression reached their maximum in the stage of haustorium formation, which is one day after inoculation. Using barely stripe mosaic virus (BSMV as a transient expression vector in wheat, the expression of PsCNA1 and PsCNB1 in Pst was suppressed, leading to slower extension of fungal hyphae and reduced production of urediospores. The immune-suppressive drugs cyclosporin A and FK506 markedly reduced the germination rates of urediospores, and when germination did occur, more than two germtubes were produced. These results suggest that the calcineurin signaling pathway participates in stripe rust morphogenetic differentiation, especially the formation of haustoria during the early stage of infection and during the production of urediospores. Therefore PsCNA1 and PsCNB1 can be considered important pathogenicity genes involved in the wheat-Pst interaction.

Perceptual Characterization of the Macronutrient Picture System (MaPS for Food Image fMRI

Directory of Open Access Journals (Sweden)

Jill L. King

2018-01-01

Full Text Available Food image fMRI paradigms are used widely for investigating the neural basis of ingestive behavior. However, these paradigms have not been validated in terms of ingestive behavior constructs, engagement of food-relevant neural systems, or test-retest reliability, making the generalizability of study findings unclear. Therefore, we validated the Macronutrient Picture System (MaPS (McClernon et al., 2013, which includes food images from the six categories represented in the Geiselman Food Preference Questionnaire (FPQ (Geiselman et al., 1998. Twenty-five healthy young adults (n = 21 female, mean age = 20.6 ± 1.1 years, mean BMI = 22.1 ± 1.9 kg/m2 rated the MaPS images in terms of visual interest, appetitive quality, nutrition, emotional valence, liking, and frequency of consumption, and completed the FPQ. In a second study, 12 individuals (n=8 female, mean age = 25.0 ± 6.5 years, mean BMI = 28.2 ± 8.7 kg/m2 viewed MaPS and control images (vegetables and non-food during two separate 3T BOLD fMRI scans after fasting overnight. Intuitively, high fat/high sugar (HF/HS and high fat/high complex carbohydrate (HF/HCCHO images achieved higher liking and appetitive ratings, and lower nutrition ratings, than low fat/low complex carbohydrate/high protein (LF/LCHO/HP images on average. Within each food category, FPQ scores correlated strongly with MaPS image liking ratings (p < 0.001. Brain activation differences between viewing images of HF/HS and vegetables, and between HF/HCCHO and vegetables, were seen in several reward-related brain regions (e.g., putamen, insula, and medial frontal gyrus. Intra-individual, inter-scan agreement in a summary measure of brain activation differences in seven reward network regions of interest was high (ICC = 0.61, and was even higher when two distinct sets of food images with matching visual ratings were shown in the two scans (ICC = 0.74. These results suggest that the MaPS provides valid representation of food

Design of DC-60 specialized accelerator for the Inter-disciplinary Laboratory Complex by the L.N. Gumilev Eurasian State University

International Nuclear Information System (INIS)

Gikal, B.N.; Itkis, M.G.; Dmitriev, S.N.; Gul'bekyan, G.G.; Franko, J.; ); Kadyrzhanov, K.K.; Arzumanov, A.A.; Borisenko, A.N.; Lysukhin, S.N.

2001-01-01

Design of the Inter-disciplinary Laboratory Complex by the L.N. Eurasian State University allows development and implementation of specialized heavy ion accelerator. According requirements of research programme the most optimal accelerator is compact cyclotron with fixed magnetic field and varying frequency of high-frequency system in dependence on mass rate to accelerated ions charge. The accelerator has two accelerating modes - on 4 and 6 harmonics, that allow to accelerate ions from C to Xe with energies from 0.4 to 1.6 MeV/nucleon. The beam take out is occurring by electrostatic deflector. The beam will be transporting to physical unit for research conducting. The cyclotron is equipped with ECR source and axial beam injection system.The extending voltage on the ion source is 10-25 k W. On the injection line it is planning to create the channel - after analyzing magnet -for using of satellite beams, that allow to conduct experiments on a low energy ions beams. In all accelerating modes the ions energy does not exceeds the Coulomb barrier and so the unit is radiation safe. The cyclotron complex could be used for fulfilment of a wide circle of research and applied tasks, as well as for students and postgraduates training

100-ps framing-camera tube

International Nuclear Information System (INIS)

Kalibjian, R.

1978-01-01

The optoelectronic framing-camera tube described is capable of recording two-dimensional image frames with high spatial resolution in the <100-ps range. Framing is performed by streaking a two-dimensional electron image across narrow slits. The resulting dissected electron line images from the slits are restored into framed images by a restorer deflector operating synchronously with the dissector deflector. The number of framed images on the tube's viewing screen equals the number of dissecting slits in the tube. Performance has been demonstrated in a prototype tube by recording 135-ps-duration framed images of 2.5-mm patterns at the cathode. The limitation in the framing speed is in the external drivers for the deflectors and not in the tube design characteristics. Faster frame speeds in the <100-ps range can be obtained by use of faster deflection drivers

PsHint1, associated with the G-protein α subunit PsGPA1, is required for the chemotaxis and pathogenicity of Phytophthora sojae.

Science.gov (United States)

Zhang, Xin; Zhai, Chunhua; Hua, Chenlei; Qiu, Min; Hao, Yujuan; Nie, Pingping; Ye, Wenwu; Wang, Yuanchao

2016-02-01

Zoospore chemotaxis to soybean isoflavones is essential in the early stages of infection by the oomycete pathogen Phytophthora sojae. Previously, we have identified a G-protein α subunit encoded by PsGPA1 which regulates the chemotaxis and pathogenicity of P. sojae. In the present study, we used affinity purification to identify PsGPA1-interacting proteins, including PsHint1, a histidine triad (HIT) domain-containing protein orthologous to human HIT nucleotide-binding protein 1 (HINT1). PsHint1 interacted with both the guanosine triphosphate (GTP)- and guanosine diphosphate (GDP)-bound forms of PsGPA1. An analysis of the gene-silenced transformants revealed that PsHint1 was involved in the chemotropic response of zoospores to the isoflavone daidzein. During interaction with a susceptible soybean cultivar, PsHint1-silenced transformants displayed significantly reduced infectious hyphal extension and caused a strong cell death in plants. In addition, the transformants displayed defective cyst germination, forming abnormal germ tubes that were highly branched and exhibited apical swelling. These results suggest that PsHint1 not only regulates chemotaxis by interacting with PsGPA1, but also participates in a Gα-independent pathway involved in the pathogenicity of P. sojae. © 2015 BSPP AND JOHN WILEY & SONS LTD.

Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease

Science.gov (United States)

Kim, Hye Yun; Kim, Hyunjin V.; Yoon, Jin H.; Kang, Bo Ram; Cho, Soo Min; Lee, Sejin; Kim, Ji Yoon; Kim, Joo Won; Cho, Yakdol; Woo, Jiwan; Kim, YoungSoo

2014-01-01

Alzheimer's disease (AD) is a lethal progressive neurological disorder affecting the memory. Recently, US Food and Drug Administration mitigated the standard for drug approval, allowing symptomatic drugs that only improve cognitive deficits to be allowed to accelerate on to clinical trials. Our study focuses on taurine, an endogenous amino acid found in high concentrations in humans. It has demonstrated neuroprotective properties against many forms of dementia. In this study, we assessed cognitively enhancing property of taurine in transgenic mouse model of AD. We orally administered taurine via drinking water to adult APP/PS1 transgenic mouse model for 6 weeks. Taurine treatment rescued cognitive deficits in APP/PS1 mice up to the age-matching wild-type mice in Y-maze and passive avoidance tests without modifying the behaviours of cognitively normal mice. In the cortex of APP/PS1 mice, taurine slightly decreased insoluble fraction of Aβ. While the exact mechanism of taurine in AD has not yet been ascertained, our results suggest that taurine can aid cognitive impairment and may inhibit Aβ-related damages. PMID:25502280

Integration of complex-wide mixed low-level waste activities for program acceleration and optimization

International Nuclear Information System (INIS)

McKenney, D.E.

1998-01-01

In July 1996, the US Department of Energy (DOE) chartered a contractor-led effort to develop a suite of technically defensible, integrated alternatives which would allow the Environmental Management program to accomplish its mission objectives in an accelerated fashion and at a reduced cost. These alternatives, or opportunities, could then be evaluated by DOE and stakeholders for possible implementation, given precursor requirements (regulatory changes, etc.) could be met and benefits to the Complex realized. This contractor effort initially focused on six waste types, one of which was Mixed Low-Level Waste (MLLW). Many opportunities were identified by the contractor team for integrating MLLW activities across the DOE Complex. These opportunities were further narrowed to six that had the most promise for implementation and savings to the DOE Complex. The opportunities include six items: (1) the consolidation of individual site analytical services procurement efforts, (2) the consolidation of individual site MLLW treatment services procurement efforts, (3) establishment of ''de minimus'' radioactivity levels, (4) standardization of characterization requirements, (5) increased utilization of existing DOE treatment facilities, and (6) using a combination of DOE and commercial MLLW disposal capacity. The results of the integration effort showed that by managing MLLW activities across the DOE Complex as a cohesive unit rather than as independent site efforts, the DOE could improve the rate of progress toward meeting its objectives and reduce its overall MLLW program costs. Savings potential for MLLW, if the identified opportunities could be implemented, could total $224 million or more. Implementation of the opportunities also could result in the acceleration of the MLLW ''work off schedule'' across the DOE Complex by five years

Synthesis and Characterization of the Rubidium Thiophosphate Rb 6 (PS 5 )(P 2 S 10 ) and the Rubidium Silver Thiophosphates Rb 2 AgPS 4 , RbAg 5 (PS 4 ) 2 and Rb 3 Ag 9 (PS 4 ) 4

KAUST Repository

Alahmary, Fatimah S.

2016-02-18

The metal thiophosphates Rb2AgPS4 (2), RbAg5(PS4)2 (3), and Rb3Ag9(PS4)4 (4) were synthesized by stoichiometric reactions, whereas Rb6(PS5)(P2S10) (1) was prepared with excess amount of sulfur. The compounds crystallize as follows: 1 monoclinic, P21/c (no. 14), a = 17.0123(7) Å, b = 6.9102(2) Å, c = 23.179(1) Å, β = 94.399(4)°; 2 triclinic, P ¯ (no. 2), a = 6.600(1) Å, b = 6.856(1) Å, c = 10.943(3) Å, α = 95.150(2)°, β = 107.338(2)°, γ = 111.383(2)°; 3 orthorhombic, Pbca (no. 61), a = 12.607(1) Å, b = 12.612(1) Å, c = 17.759(2) Å; 4 orthorhombic, Pbcm (no. 57), a = 6.3481(2) Å, b = 12.5782(4) Å, c = 35.975(1) Å. The crystal structures contain discrete units, chains, and 3D polyanionic frameworks composed of PS4 tetrahedral units arranged and connected in different manner. Compounds 1-3 melt congruently, whereas incongruent melting behavior was observed for compound 4. 1-4 are semiconductors with bandgaps between 2.3 and 2.6 eV and thermally stable up to 450 °C in an inert atmosphere. Copyright © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

High-precision calculation of loosely bound states of LiPs+ and NaPs+

International Nuclear Information System (INIS)

Yamashita, Takuma; Kino, Yasushi

2015-01-01

A positronic alkali atom would be the first step to investigate behavior of a positronium(Ps) in an external field from atoms/molecules because the system can be regarded as a simple three-body system using model potentials reflecting electron orbitals of the ion core. In order to precisely determine binding energies and structures of positronic alkali atoms (LiPs + and NaPs + ), we improve the model potential so as to reproduce highly excited atomic energy levels of alkali atoms (Li and Na). The polarization potential included by the model potential is expanded in terms of Gaussian functions to finely determine a short range part of the potential which has been assumed to be a simple form. We find better reproducibility not only of atomic levels of the alkali atoms but also of the dipole polarizability of the core ion than previous works. We construct a model potential between a positron and an ion core based on the model potential between the valence electron and ion core. Binding energies associated with a dissociation of the alkali ion core and positronium, and interparticle distances are recalculated. Our results show slightly deeper bound than other previous studies. (paper)

Accelerator magnet power supply using storage generator

International Nuclear Information System (INIS)

Karady, G.; Thiessen, H.A.

1987-01-01

Recently, a study investigated the feasibility of a large, 60 GeV accelerator. This paper presents the conceptual design of the magnet power supply (PS() and energy storage system. The main ring magnets are supplied by six, high-voltage and two, low-voltage power supplies. These power supplies drive a trapezoidal shaped current wave through the magnets. The peak current is 10 kA and the repetition frequency is 3.3 Hz. During the acceleration period the current is increased from 1040 A to 10,000 A within 50 msec which requires a loop voltage of 120 kV and a peak power of 1250 MW. During the reset period, the PS operates as an inverter with a peak power of -1250 MW. The large energy fluctuation necessitates the use of a storage generator. Because of the relatively high operation frequency, this generator operates in a transient mode which significantly increases the rotor current and losses. The storage generator is directly driven by a variable speed drive, which draws a practically constant power of 17 MW from the ac supply network and eliminates the pulse loading. For the reduction of dc ripple, the power supplies operate in a 24 pulse mode

25th anniversary for Linac-2

CERN Multimedia

2003-01-01

On Friday, 3 October 2003, the Linac team celebrated a quarter century of successful operation of one of its linear accelerators: Linac-2, the proton workhorse of the CERN accelerator complex. Linac-2, CERN's linear proton accelerator, has now been running for 25 years - ample reason for a small celebration. About 30 members of the original team (10 of the initially more than 50 are still working at CERN), and other CERN personnel met on 3 October 2003. Linac-2 is the first link in the accelerator chain Linac-2 - PS Booster - PS - SPS and eventually LHC. Beams from Linac-2 are used after further acceleration in the CERN complex for SPS fixed target physics; for antiproton production for the Antiproton Decelerator (AD); for test beams in the East Experimental Hall and in the PS; for nuclear physics at ISOLDE; for LHC test beams and in the past for both ISR physics and Antiproton production (AA/AC) and test beams in LEAR. Linac-2 was built to obtain higher intensities and better stability than with ...

Phosphorene-directed self-assembly of asymmetric PS-b-PMMA block copolymer for perpendicularly-oriented sub-10 nm PS nanopore arrays

Science.gov (United States)

Zhang, Ziming; Zheng, Lu; Khurram, Muhammad; Yan, Qingfeng

2017-10-01

Few-layer black phosphorus, also known as phosphorene, is a new two-dimensional material which is of enormous interest for applications, mainly in electronics and optoelectronics. Herein, we for the first time employ phosphorene for directing the self-assembly of asymmetric polystyrene-block-polymethylmethacrylate (PS-b-PMMA) block copolymer (BCP) thin film to form the perpendicular orientation of sub-10 nm PS nanopore arrays in a hexagonal fashion normal to the interface. We experimentally demonstrate that none of the PS and PMMA blocks exhibit preferential affinity to the phosphorene-modified surface. Furthermore, the perpendicularly-oriented PS nanostructures almost stay unchanged with the variation of number of layers of few-layer phosphorene nanoflakes between 15-30 layers. Differing from the neutral polymer brushes which are widely used for chemical modification of the silicon substrate, phosphorene provides a novel physical way to control the interfacial interactions between the asymmetric PS-b-PMMA BCP thin film and the silicon substrate. Based on our results, it is possible to build a new scheme for producing sub-10 nm PS nanopore arrays oriented perpendicularly to the few-layer phosphorene nanoflakes. Furthermore, the nanostructural microdomains could serve as a promising nanolithography template for surface patterning of phosphorene nanoflakes.

Phosphorene-directed self-assembly of asymmetric PS-b-PMMA block copolymer for perpendicularly-oriented sub-10 nm PS nanopore arrays.

Science.gov (United States)

Zhang, Ziming; Zheng, Lu; Khurram, Muhammad; Yan, Qingfeng

2017-10-20

Few-layer black phosphorus, also known as phosphorene, is a new two-dimensional material which is of enormous interest for applications, mainly in electronics and optoelectronics. Herein, we for the first time employ phosphorene for directing the self-assembly of asymmetric polystyrene-block-polymethylmethacrylate (PS-b-PMMA) block copolymer (BCP) thin film to form the perpendicular orientation of sub-10 nm PS nanopore arrays in a hexagonal fashion normal to the interface. We experimentally demonstrate that none of the PS and PMMA blocks exhibit preferential affinity to the phosphorene-modified surface. Furthermore, the perpendicularly-oriented PS nanostructures almost stay unchanged with the variation of number of layers of few-layer phosphorene nanoflakes between 15-30 layers. Differing from the neutral polymer brushes which are widely used for chemical modification of the silicon substrate, phosphorene provides a novel physical way to control the interfacial interactions between the asymmetric PS-b-PMMA BCP thin film and the silicon substrate. Based on our results, it is possible to build a new scheme for producing sub-10 nm PS nanopore arrays oriented perpendicularly to the few-layer phosphorene nanoflakes. Furthermore, the nanostructural microdomains could serve as a promising nanolithography template for surface patterning of phosphorene nanoflakes.

Ruthenium chalcogenonitrosyl and bridged nitrido complexes containing chelating sulfur and oxygen ligands.

Science.gov (United States)

Ng, Ho-Yuen; Cheung, Wai-Man; Kwan Huang, Enrique; Wong, Kang-Long; Sung, Herman H-Y; Williams, Ian D; Leung, Wa-Hung

2015-11-14

Ruthenium thio- and seleno-nitrosyl complexes containing chelating sulfur and oxygen ligands have been synthesised and their de-chalcogenation reactions have been studied. The reaction of mer-[Ru(N)Cl3(AsPh3)2] with elemental sulfur and selenium in tetrahydrofuran at reflux afforded the chalcogenonitrosyl complexes mer-[Ru(NX)Cl3(AsPh3)2] [X = S (1), Se (2)]. Treatment of 1 with KN(R2PS)2 afforded trans-[Ru(NS)Cl{N(R2PS)2}2] [R = Ph (3), Pr(i) (4), Bu(t) (5)]. Alternatively, the thionitrosyl complex 5 was obtained from [Bu(n)4N][Ru(N)Cl4] and KN(Bu(t)2PS)2, presumably via sulfur atom transfer from [N(Bu(t)2PS)2](-) to the nitride. Reactions of 1 and 2 with NaLOEt (LOEt(-) = [Co(η(5)-C5H5){P(O)(LOEt)2}3](-)) gave [Ru(NX)LOEtCl2] (X = S (8), Se (9)). Treatment of [Bu(n)4N][Ru(N)Cl4] with KN(R2PS)2 produced Ru(IV)-Ru(IV)μ-nitrido complexes [Ru2(μ-N){N(R2PS)2}4Cl] [R = Ph (6), Pr(i) (7)]. Reactions of 3 and 9 with PPh3 afforded 6 and [Ru(NPPh3)LOEtCl2], respectively. The desulfurisation of 5 with [Ni(cod)2] (cod = 1,5-cyclooctadiene) gave the mixed valance Ru(III)-Ru(IV)μ-nitrido complex [Ru2(μ-N){N(Bu(t)2PS)2}4] (10) that was oxidised by [Cp2Fe](PF6) to give the Ru(IV)-Ru(IV) complex [Ru2(μ-N){N(Bu(t)2PS)2}4](PF6) ([10]PF6). The crystal structures of 1, 2, 3, 7, 9 and 10 have been determined.

The first terawatt picosecond CO2 laser for advanced accelerator studies at the Brookhaven ATF

International Nuclear Information System (INIS)

Pogorelsky, I.V.; Ben-Zvi, I.; Skaritka, J.

1996-10-01

The first terawatt picosecond C0 2 laser system is under development at the Brookhaven Accelerator Test Facility. Presently operational 1 Joule 100-ps ATF laser will be upgraded with a 10 atm amplifier capable of delivery ∼ 15 Joules of laser energy in a 3 ps pulse. We describe the design of the x-ray preionized 10 atm amplifier of a 10 liter active volume energized by a 1 MV, 200 kA transverse electric discharge. The amplifier, equipped with internal optics, permits the accommodation of a regenerative stage and a multi-pass booster in a relatively compact single discharge volume. The ATF terawatt C0 2 laser shall become operational in 1997 to serve for laser acceleration, x-ray generation and other strong-field physics experiments

The PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro.

Directory of Open Access Journals (Sweden)

Simon K W Lam

Full Text Available The pre-sensor 1 (PS1 hairpin is found in ring-shaped helicases of the AAA+ family (ATPases associated with a variety of cellular activities of proteins and is implicated in DNA translocation during DNA unwinding of archaeal mini-chromosome maintenance (MCM and superfamily 3 viral replicative helicases. To determine whether the PS1 hairpin is required for the function of the eukaryotic replicative helicase, Mcm2-7 (also comprised of AAA+ proteins, we mutated the conserved lysine residue in the putative PS1 hairpin motif in each of the Saccharomyces cerevisiae Mcm2-7 subunits to alanine. Interestingly, only the PS1 hairpin of Mcm3 was essential for viability. While mutation of the PS1 hairpin in the remaining MCM subunits resulted in minimal phenotypes, with the exception of Mcm7 which showed slow growth under all conditions examined, the viable alleles were synthetic lethal with each other. Reconstituted Mcm2-7 containing Mcm3 with the PS1 mutation (Mcm3(K499A had severely decreased helicase activity. The lack of helicase activity provides a probable explanation for the inviability of the mcm3(K499A strain. The ATPase activity of Mcm2-7(3K499A was similar to the wild type complex, but its interaction with single-stranded DNA in an electrophoretic mobility shift assay and its associations in cells were subtly altered. Together, these findings indicate that the PS1 hairpins in the Mcm2-7 subunits have important and distinct functions, most evident by the essential nature of the Mcm3 PS1 hairpin in DNA unwinding.

Comparative, validity and responsiveness of the HOOS-PS and KOOS-PS to the WOMAC physical function subscale in total joint replacement for osteoarthritis

DEFF Research Database (Denmark)

Davis, A M; Perruccio, A V; Canizares, M

2009-01-01

OBJECTIVE: To evaluate the internal consistency of the Hip disability and Osteoarthritis Outcome Score-Physical Function Short-form (HOOS-PS) and the Knee injury and Osteoarthritis Outcome Score-Physical Function Short-form (KOOS-PS) in total hip replacement (THR) and total knee (TKR) replacement....... Construct validity and responsiveness were compared to the Western Ontario McMaster Universities' Osteoarthritis Index (WOMAC) Likert 3.0 physical function (PF) subscale and the PF excluding the items in the short measures (PF-exclusions). METHODS: Participants completed the full HOOS or KOOS, measures...... of fatigue, anxiety, depression and the Chronic Pain Grade (CPG) pre-surgery and the HOOS or KOOS 6 months post-surgery. Internal consistency for the HOOS-PS and KOOS-PS was calculated using Cronbach's alpha. For construct validity, it was hypothesized that correlations between the HOOS-PS or KOOS-PS and PF...

Plasma based charged-particle accelerators

International Nuclear Information System (INIS)

Bingham, R; Mendonca, J T; Shukla, P K

2004-01-01

Studies of charged-particle acceleration processes remain one of the most important areas of research in laboratory, space and astrophysical plasmas. In this paper, we present the underlying physics and the present status of high gradient and high energy plasma accelerators. We will focus on the acceleration of charged particles to relativistic energies by plasma waves that are created by intense laser and particle beams. The generation of relativistic plasma waves by intense lasers or electron beams in plasmas is important in the quest for producing ultra-high acceleration gradients for accelerators. With the development of compact short pulse high brightness lasers and electron positron beams, new areas of studies for laser/particle beam-matter interactions is opening up. A number of methods are being pursued vigorously to achieve ultra-high acceleration gradients. These include the plasma beat wave accelerator mechanism, which uses conventional long pulse (∼100 ps) modest intensity lasers (I ∼ 10 14 -10 16 W cm -2 ), the laser wakefield accelerator (LWFA), which uses the new breed of compact high brightness lasers ( 10 18 W cm -2 , the self-modulated LWFA concept, which combines elements of stimulated Raman forward scattering, and electron acceleration by nonlinear plasma waves excited by relativistic electron and positron bunches. In the ultra-high intensity regime, laser/particle beam-plasma interactions are highly nonlinear and relativistic, leading to new phenomena such as the plasma wakefield excitation for particle acceleration, relativistic self-focusing and guiding of laser beams, high-harmonic generation, acceleration of electrons, positrons, protons and photons. Fields greater than 1 GV cm -1 have been generated with particles being accelerated to 200 MeV over a distance of millimetre. Plasma wakefields driven by positron beams at the Stanford Linear Accelerator Center facility have accelerated the tail of the positron beam. In the near future

The LLL compact 10-ps streak camera

International Nuclear Information System (INIS)

Thomas, S.W.; Houghton, J.W.; Tripp, G.R.; Coleman, L.W.

1975-01-01

The 10-ps streak camera has been redesigned to simplify its operation, reduce manufacturing costs, and improve its appearance. The electronics have been simplified, a film indexer added, and a contacted slit has been evaluated. Data support a 10-ps resolution. (author)

PS, SL and LHC Auditoria change names

CERN Multimedia

2003-01-01

Following the replacement of the PS, SL and LHC Divisions by the AB and AT Divisions, the Auditoria are also changing their names. PS Auditorium is renamed AB Meyrin SL Auditorium is renamed AB Prévessin LHC Auditorium is renamed AT

Initial Observations of Micropulse Elongation of Electron Beams in a SCRF Accelerator

Energy Technology Data Exchange (ETDEWEB)

Lumpkin, A. H. [Fermilab; Thurman-Keup, R. [Fermilab; Edstrom Jr., D. [Fermilab; Ruan, J. [Fermilab; Santucci, J. [Fermilab

2016-10-09

Commissioning at the SCRF accelerator at the Fermilab Accelerator Science and Technology (FAST) Facility has included the implementation of a versatile bunch-length monitor located after the 4-dipole chicane bunch compressor for electron beam energies of 20-50 MeV and integrated charges in excess of 10 nC. The team has initially used a Hamamatsu C5680 synchroscan streak camera to assess the effects of space charge on the electron beam bunch lengths. An Al-coated Si screen was used to generate optical transition radiation (OTR) resulting from the beam’s interaction with the screen. The chicane bypass beamline allowed the measurements of the bunch length without the compression stage at the downstream beamline location using OTR and the streak camera. We have observed electron beam bunch lengths from 5 to 16 ps (sigma) for micropulse charges of 60 pC to 800 pC, respectively. We also report a compressed sub-ps micropulse case.

Human hair follicle pluripotent stem (hfPS) cells promote regeneration of peripheral-nerve injury: an advantageous alternative to ES and iPS cells.

Science.gov (United States)

Amoh, Yasuyuki; Kanoh, Maho; Niiyama, Shiro; Hamada, Yuko; Kawahara, Katsumasa; Sato, Yuichi; Hoffman, Robert M; Katsuoka, Kensei

2009-08-01

The optimal source of stem cells for regenerative medicine is a major question. Embryonic stem (ES) cells have shown promise for pluripotency but have ethical issues and potential to form teratomas. Pluripotent stem cells have been produced from skin cells by either viral-, plasmid- or transposon-mediated gene transfer. These stem cells have been termed induced pluripotent stem cells or iPS cells. iPS cells may also have malignant potential and are inefficiently produced. Embryonic stem cells may not be suited for individualized therapy, since they can undergo immunologic rejection. To address these fundamental problems, our group is developing hair follicle pluripotent stem (hfPS) cells. Our previous studies have shown that mouse hfPS cells can differentiate to neurons, glial cells in vitro, and other cell types, and can promote nerve and spinal cord regeneration in vivo. hfPS cells are located above the hair follicle bulge in what we have termed the hfPS cell area (hfPSA) and are nestin positive and keratin 15 (K-15) negative. Human hfPS cells can also differentiate into neurons, glia, keratinocytes, smooth muscle cells, and melanocytes in vitro. In the present study, human hfPS cells were transplanted in the severed sciatic nerve of the mouse where they differentiated into glial fibrillary-acidic-protein (GFAP)-positive Schwann cells and promoted the recovery of pre-existing axons, leading to nerve generation. The regenerated nerve recovered function and, upon electrical stimulation, contracted the gastrocnemius muscle. The hfPS cells can be readily isolated from the human scalp, thereby providing an accessible, autologous and safe source of stem cells for regenerative medicine that have important advantages over ES or iPS cells. (c) 2009 Wiley-Liss, Inc.

The Accelerator Complex of CESLAB

Czech Academy of Sciences Publication Activity Database

Pokorná, Zuzana; Růžička, Bohdan

2008-01-01

Roč. 15, 1a (2008), s13-17 ISSN 1211-5894. [Struktura 2008 - colloquium of the Czech and Slovak Crystallographic Association. Valtice, 16.06.2008-20.06.2008] Institutional research plan: CEZ:AV0Z20650511 Keywords : accelerator * synchrotron radiation * linac * booster * storage ring * insertion device Subject RIV: BF - Elementary Particles and High Energy Physics

Psühhodraama - spontaansuse kool / Taimi Elenurm

Index Scriptorium Estoniae

Elenurm, Taimi

2010-01-01

Viinis ja New Yorgis tegutsenud psühhiaatri Jakob Levy Moreno loodud psühhodraamast, mis võimaldab rollimängu kaudu näha ennast läbi teiste silmade, aga ka vabaneda pingetest andes võimaluse käituda teisiti kui tavaelus

Pulse-dilation enhanced gated optical imager with 5 ps resolution (invited)

Energy Technology Data Exchange (ETDEWEB)

Hilsabeck, T. J.; Kilkenny, J. D. [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States); Hares, J. D.; Dymoke-Bradshaw, A. K. L. [Kentech Instruments Ltd., Wallingford, Oxfordshire OX10 (United Kingdom); Bell, P. M.; Koch, J. A.; Celliers, P. M.; Bradley, D. K.; McCarville, T.; Pivovaroff, M.; Soufli, R.; Bionta, R. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States)

2010-10-15

A 5 ps gated framing camera was demonstrated using the pulse-dilation of a drifting electron signal. The pulse-dilation is achieved by accelerating a photoelectron derived information pulse with a time varying potential [R. D. Prosser, J. Phys. E 9, 57 (1976)]. The temporal dependence of the accelerating potential causes a birth time dependent axial velocity dispersion that spreads the pulse as it transits a drift region. The expanded pulse is then imaged with a conventional gated microchannel plate based framing camera and the effective gating time of the combined instrument is reduced over that of the framing camera alone. In the drift region, electron image defocusing in the transverse or image plane is prevented with a large axial magnetic field. Details of the unique issues associated with rf excited photocathodes were investigated numerically and a prototype instrument based on this principle was recently constructed. Temporal resolution of the instrument was measured with a frequency tripled femtosecond laser operating at 266 nm. The system demonstrated 20x temporal magnification and the results are presented here. X-ray image formation strategies and photometric calculations for inertial confinement fusion implosion experiments are also examined.

Approach to the open advanced facilities initiative for innovation (strategic use by industry) at the University of Tsukuba, Tandem Accelerator Complex

International Nuclear Information System (INIS)

Sasa, K.; Tagishi, Y.; Naramoto, H.; Kudo, H.; Kita, E.

2010-01-01

The University of Tsukuba, Tandem Accelerator Complex (UTTAC) possesses the 12UD Pelletron tandem accelerator and the 1 MV Tandetron accelerator for University's inter-department education research. We have actively advanced collaborative researches with other research institutes and industrial users. Since the Open Advanced Facilities Initiative for Innovation by the Ministry of Education, Culture, Sports, Science and Technology started in 2007, 12 industrial experiments have been carried out at the UTTAC. This report describes efforts by University's accelerator facility to get industrial users. (author)

ELYSE, a new picosecond electron accelerator at Orsay

International Nuclear Information System (INIS)

Belloni, J.D.; Gaillard, M.; Monard, H.; Larbre, J.-P.; Gobert, F.; Mostafavi, M.; Lampre, I.; Marignier, J.-L.

2003-01-01

ELYSE is a new instrument allowing to study fast kinetics processes at picosecond range by the complementary techniques of pulse radiolysis and laser photochemistry which was installed by the Laboratoire de Chimie Physique, University Paris-Sud, at Orsay. It was designed and constructed by the Linear Accelerator Laboratory, Orsay. The accelerator is a RF photocathode electron gun type which will deliver electron pulses of less than 5 ps FWHM. The Cs 2 Te cathode was chosen because of its high efficiency and long life time. Photoelectrons are generated by a picosecond synchronized laser system with a normal incidence. The charge per pulse is 1 nC with a dark current less than 1 % and a repetition frequency 1 to 50 Hz. Other detailed specifications of the accelerator, of the laser and of the optical spectroscopy detection set-up are described

Charge Diagnostics for Laser Plasma Accelerators

International Nuclear Information System (INIS)

Nakamura, K.; Gonsalves, A.J.; Lin, C.; Sokollik, T.; Smith, A.; Rodgers, D.; Donahue, R.; Bryne, W.; Leemans, W.P.

2010-01-01

The electron energy dependence of a scintillating screen (Lanex Fast) was studied with sub-nanosecond electron beams ranging from 106 MeV to 1522 MeV at the Lawrence Berkeley National Laboratory Advanced Light Source (ALS) synchrotron booster accelerator. The sensitivity of the Lanex Fast decreased by 1percent per 100 MeV increase of the energy. The linear response of the screen against the charge was verified with charge density and intensity up to 160 pC/mm2 and 0.4 pC/ps/mm2, respectively. For electron beams from the laser plasma accelerator, a comprehensive study of charge diagnostics has been performed using a Lanex screen, an integrating current transformer, and an activation based measurement. The charge measured by each diagnostic was found to be within +/-10 percent.

Charge Diagnostics for Laser Plasma Accelerators

International Nuclear Information System (INIS)

Nakamura, K.; Gonsalves, A. J.; Lin, C.; Sokollik, T.; Smith, A.; Rodgers, D.; Donahue, R.; Bryne, W.; Leemans, W. P.

2010-01-01

The electron energy dependence of a scintillating screen (Lanex Fast) was studied with sub-nanosecond electron beams ranging from 106 MeV to 1522 MeV at the Lawrence Berkeley National Laboratory Advanced Light Source (ALS) synchrotron booster accelerator. The sensitivity of the Lanex Fast decreased by 1% per 100 MeV increase of the energy. The linear response of the screen against the charge was verified with charge density and intensity up to 160 pC/mm 2 and 0.4 pC/ps/mm 2 , respectively. For electron beams from the laser plasma accelerator, a comprehensive study of charge diagnostics has been performed using a Lanex screen, an integrating current transformer, and an activation based measurement. The charge measured by each diagnostic was found to be within ±10%.

Ps 22 in Gospels’ interpretation of Passion

Directory of Open Access Journals (Sweden)

Sylwester Jędrzejewski

2012-09-01

Full Text Available Ps 22 is a piece of artistically high poetry, clear images and metaphors, historical and prophetic references. The conviction of biblical scholars that the New Testament writers has recognized in Ps 22 prophetic witness of passion, accompanies the Church from its beginnings. The words of Jesus on the cross, taken from Ps 22: 2, have a character of lamentable re-symbolization of the prayer of Israel. These words establish a theological answer in the form of suitable credo as well. Dramatic question “why?” is connected with a proclamation and identification “My God”. The personal experience of oppression and death is included by Jesus in the history of his nation and in the experience of God. Ps 22 in the Gospels’ passion context becomes a proclamation form of prayer and a very personal, expressed in such dramatic circumstances confession of the faith.

CERN Proton Synchrotron Complex High-Level Controls Renovation

CERN Document Server

Deghaye, S; Garcia Quintas, D; Gourber-Pace, M; Kruk, G; Kulikova, O; Lezhebokov, V; Pasinelli, S; Peryt, M; Roderick, C; Roux, E; Sobczak, M; Steerenberg, R; Wozniak, J; Zaharieva, Z

2009-01-01

After a detailed study of the Proton Synchrotron (PS) complex requirements by experts of CERN controls & operation groups, a proposal to develop a new system, called Injector Controls Architecture (InCA), was presented to and accepted by the management late 2007. Aiming at the homogenisation of the control systems across CERN accelerators, InCA is based on components developed for the Large Hadron Collider (LHC) but also new components required to fulfil operation needs. In 2008, the project was in its elaboration phase and we successfully validated its architecture and critical use-cases during several machine development sessions. After description of the architecture put in place and the components used, this paper describes the planning approach taken combining iterative development phases with deployment in operation for validation sessions.

The operational status of the Booster injector for the AGS accelerator complex at BNL

International Nuclear Information System (INIS)

Ahrens, L.; Bleser, E.; Brennan, J.M.; Gardner, C.; Gill, E.; Glenn, J.W.; Reece, K.; Roser, T.; van Asselt, W.; Weng, W.T.

1992-01-01

The Booster synchrotron at Brookhaven National Laboratory has been incorporated into the accelerator chain at the Alternating Gradient Synchrotron (AGS) complex. After a successful first commissioning effort in the spring of 1991, the Booster has been part of this year's silicon, gold and proton physics runs. After a brief review of the Booster design goals, and of the early commissioning, this paper will summarize this year's activities

Real-life experience of using conventional disease-modifying anti-rheumatic drugs (DMARDs) in psoriatic arthritis (PsA). Retrospective analysis of the efficacy of methotrexate, sulfasalazine, and leflunomide in PsA in comparison to spondyloarthritides other than PsA and literature review of the use of conventional DMARDs in PsA

Science.gov (United States)

Roussou, Euthalia; Bouraoui, Aicha

2017-01-01

Objective With the aim of assessing the response to treatment with conventional disease-modifying anti-rheumatic drugs (DMARDs) used in patients with psoriatic arthritis (PsA), data on methotrexate, sulfasalazine (SSZ), and leflunomide were analyzed from baseline and subsequent follow-up (FU) questionnaires completed by patients with either PsA or other spondyloarthritides (SpAs). Material and Methods A single-center real-life retrospective analysis was performed by obtaining clinical data via questionnaires administered before and after treatment. The indices used were erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Function Index (BASFI), wellbeing (WB), and treatment effect (TxE). The indices measured at baseline were compared with those measured on one occasion in a FU visit at least 1 year later. Results A total of 73 patients, 51 with PsA (mean age 49.8±12.8 years; male-to-female ratio [M:F]=18:33) and 22 with other SpAs (mean age 50.6±16 years; M:F=2:20), were studied. BASDAI, BASFI, and WB displayed consistent improvements during FU assessments in both PsA patients and controls in comparison to baseline values. SSZ exhibited better efficacy as confirmed by TxE in both PsA patients and controls. ESR and CRP displayed no differences in either the PsA or the SpA group between the cases before and after treatment. Conclusion Real-life retrospective analysis of three DMARDs used in PsA (and SpAs other than PsA) demonstrated that all three DMARDs that were used brought about improvements in BASDAI, BASFI, TxE, and WB. However, the greatest improvements at FU were seen with SSZ use in both PsA and control cohorts. PMID:28293446

High energy gain electron beam acceleration by 100TW laser

International Nuclear Information System (INIS)

Kotaki, Hideyuki; Kando, Masaki; Kondo, Shuji; Hosokai, Tomonao; Kanazawa, Shuhei; Yokoyama, Takashi; Matoba, Toru; Nakajima, Kazuhisa

2001-01-01

A laser wakefield acceleration experiment using a 100TW laser is planed at JAERI-Kansai. High quality and short pulse electron beams are necessary to accelerate the electron beam by the laser. Electron beam - laser synchronization is also necessary. A microtron with a photocathode rf-gun was prepared as a high quality electron injector. The quantum efficiency (QE) of the photocathode of 2x10 -5 was obtained. A charge of 100pC from the microtron was measured. The emittance and pulse width of the electron beam was 6π mm-mrad and 10ps, respectively. In order to produce a short pulse electron beam, and to synchronize between the electron beam and the laser pulse, an inverse free electron laser (IFEL) is planned. One of problems of LWFA is the short acceleration length. In order to overcome the problem, a Z-pinch plasma waveguide will be prepared as a laser wakefield acceleration tube for 1 GeV acceleration. (author)

Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation.

Science.gov (United States)

Tesco, G; Kim, T W; Diehlmann, A; Beyreuther, K; Tanzi, R E

1998-12-18

beta-Catenin has previously been shown to interact with presenilin 1 (PS1) in transfected cells. Here we report that beta-catenin co-immunoprecipitates with the endogenous C-terminal fragment of presenilin 1 (PS1-CTF) but not with the endogenous CTF of presenilin 2 (PS2-CTF) in H4 human neuroglioma cells. During staurosporine (STS)-induced cell death, beta-catenin and PS1-CTF undergo a caspase-mediated cleavage. After 12 h of STS treatment, the beta-catenin.PS1-CTF interaction is abrogated. While PS1-CTF immunoprecipitated with all caspase-cleaved species of beta-catenin, beta-catenin holoprotein did not co-immunoprecipitate with the "alternative" caspase-derived PS1-CTF (PS1-aCTF). Thus, the abrogation of the beta-catenin.PS1-CTF complex was due to caspase cleavage of PS1-CTF. beta-Catenin co-immunoprecipitated with PS1-NTF, but only when PS1-NTF was associated with PS1-CTF. Even though PS1-NTF.CTF complex stability was not altered by caspase cleavage, its ability to bind beta-catenin was abolished. Thus, while the PS1-NTF.CTF complex is preserved after caspase cleavage, it may no longer be fully functional.

Bunch monitor for an S-band electron linear accelerator

International Nuclear Information System (INIS)

Otake, Yuji; Nakahara, Kazuo

1991-01-01

The measurement of bunch characteristics in an S-band electron linear accelerator is required in order to evaluate the quality of accelerated electron beams. A new-type bunch monitor has been developed which combines micro-stripline technology with an air insulator and wall-current monitoring technology. The obtained time resolution of the monitor was more than 150 ps. This result shows that the monitor can handle the bunch number of an S-band linac. The structure of the monitor is suitable for being installed in the vacuum area, since it is constructed of only metal and ceramic parts. It can therefore easily be employed in an actual machine

Efficient energy absorption of intense ps-laser pulse into nanowire target

Energy Technology Data Exchange (ETDEWEB)

Habara, H.; Honda, S.; Katayama, M.; Tanaka, K. A. [Graduate School of Engineering, Osaka University, 2-1 Suita, Osaka 565-0871 (Japan); Sakagami, H. [National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Nagai, K. [Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Nagatsuda 4259, Midori-ku, Yokohama 226-8503, Kanagawa (Japan)

2016-06-15

The interaction between ultra-intense laser light and vertically aligned carbon nanotubes is investigated to demonstrate efficient laser-energy absorption in the ps laser-pulse regime. Results indicate a clear enhancement of the energy conversion from laser to energetic electrons and a simultaneously small plasma expansion on the surface of the target. A two-dimensional plasma particle calculation exhibits a high absorption through laser propagation deep into the nanotube array, even for a dense array whose structure is much smaller than the laser wavelength. The propagation leads to the radial expansion of plasma perpendicular to the nanotubes rather than to the front side. These features may contribute to fast ignition in inertial confinement fusion and laser particle acceleration, both of which require high current and small surface plasma simultaneously.

European Committee for Future Accelerators

International Nuclear Information System (INIS)

Mulvey, John

1983-01-01

Nearly 21 years ago, in December 1962, Viktor Weisskopf and Cecil Powell, then respectively CERN's Director General and Chairman of the Scientific Policy Committee, called together a group of European high energy physicists to advise on steps to reach higher energy. The CERN PS had been in operation since 1959, its experimental programme was well established and the time had come to think of the future. The Chairman of the group, which later took the title 'European Committee for Future Accelerators', was Edoardo Amaldi and his influential report, presented to the CERN Council in June 1963, reviewed the whole structure and possible development of the field in the CERN Member States. Its proposals included the construction of the Intersecting Storage Rings (ISR), and of a 300 GeV proton accelerator which was then envisaged as being the major facility of a second CERN Laboratory elsewhere in Europe

Updating the Psoriatic Arthritis (PsA) Core Domain Set

DEFF Research Database (Denmark)

Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J

2017-01-01

OBJECTIVE: To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). METHODS: At OMERACT 2016, research...... conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants. RESULTS: We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted...... and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA Core Domain Set endorsed with 90% agreement by OMERACT 2016 participants included musculoskeletal disease activity, skin disease activity, fatigue, pain, patient's global assessment, physical function, health...

Effect of moisture on disintegration kinetics during anaerobic digestion of complex organic substrates.

Science.gov (United States)

Liotta, Flavia; d'Antonio, Giuseppe; Esposito, Giovanni; Fabbricino, Massimiliano; Frunzo, Luigi; van Hullebusch, Eric D; Lens, Piet N L; Pirozzi, Francesco

2014-01-01

The role of the moisture content and particle size (PS) on the disintegration of complex organic matter during the wet anaerobic digestion (AD) process was investigated. A range of total solids (TS) from 5% to 11.3% and PS from 0.25 to 15 mm was evaluated using carrot waste as model complex organic matter. The experimental results showed that the methane production rate decreased with higher TS and PS. A modified version of the AD model no.1 for complex organic substrates was used to model the experimental data. The simulations showed a decrease of the disintegration rate constants with increasing TS and PS. The results of the biomethanation tests were used to calibrate and validate the applied model. In particular, the values of the disintegration constant for various TS and PS were determined. The simulations showed good agreement between the numerical and observed data.

An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells

Science.gov (United States)

Wei, Tingyi; Chen, Wen; Wang, Xiukun; Zhang, Man; Chen, Jiayu; Zhu, Songcheng; Chen, Long; Yang, Dandan; Wang, Guiying; Jia, Wenwen; Yu, Yangyang; Duan, Tao; Wu, Minjuan; Liu, Houqi; Gao, Shaorong; Kang, Jiuhong

2015-01-01

The maturation of induced pluripotent stem cells (iPS) is one of the limiting steps of somatic cell reprogramming, but the underlying mechanism is largely unknown. Here, we reported that knockdown of histone deacetylase 2 (HDAC2) specifically promoted the maturation of iPS cells. Further studies showed that HDAC2 knockdown significantly increased histone acetylation, facilitated TET1 binding and DNA demethylation at the promoters of iPS cell maturation-related genes during the transition of pre-iPS cells to a fully reprogrammed state. We also found that HDAC2 competed with TET1 in the binding of the RbAp46 protein at the promoters of maturation genes and knockdown of TET1 markedly prevented the activation of these genes. Collectively, our data not only demonstrated a novel intrinsic mechanism that the HDAC2-TET1 switch critically regulates iPS cell maturation, but also revealed an underlying mechanism of the interplay between histone acetylation and DNA demethylation in gene regulation. PMID:25934799

Quasi-monoenergetic ion beam acceleration by laser-driven shock and solitary waves in near-critical plasmas

International Nuclear Information System (INIS)

Zhang, W. L.; Qiao, B.; Huang, T. W.; Shen, X. F.; You, W. Y.; Yan, X. Q.; Wu, S. Z.; Zhou, C. T.; He, X. T.

2016-01-01

Ion acceleration in near-critical plasmas driven by intense laser pulses is investigated theoretically and numerically. A theoretical model has been given for clarification of the ion acceleration dynamics in relation to different laser and target parameters. Two distinct regimes have been identified, where ions are accelerated by, respectively, the laser-induced shock wave in the weakly driven regime (comparatively low laser intensity) and the nonlinear solitary wave in the strongly driven regime (comparatively high laser intensity). Two-dimensional particle-in-cell simulations show that quasi-monoenergetic proton beams with a peak energy of 94.6 MeV and an energy spread 15.8% are obtained by intense laser pulses at intensity I_0 = 3 × 10"2"0" W/cm"2 and pulse duration τ = 0.5 ps in the strongly driven regime, which is more advantageous than that got in the weakly driven regime. In addition, 233 MeV proton beams with narrow spread can be produced by extending τ to 1.0 ps in the strongly driven regime.

Quasi-monoenergetic ion beam acceleration by laser-driven shock and solitary waves in near-critical plasmas

Energy Technology Data Exchange (ETDEWEB)

Zhang, W. L.; Qiao, B., E-mail: bqiao@pku.edu.cn; Huang, T. W.; Shen, X. F.; You, W. Y. [Center for Applied Physics and Technology, HEDPS, and State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871 (China); Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan, Shanxi 030006 (China); Yan, X. Q. [Center for Applied Physics and Technology, HEDPS, and State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871 (China); Wu, S. Z. [Institute of Applied Physics and Computational Mathematics, Beijing 100094 (China); Zhou, C. T.; He, X. T. [Center for Applied Physics and Technology, HEDPS, and State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871 (China); Institute of Applied Physics and Computational Mathematics, Beijing 100094 (China)

2016-07-15

Ion acceleration in near-critical plasmas driven by intense laser pulses is investigated theoretically and numerically. A theoretical model has been given for clarification of the ion acceleration dynamics in relation to different laser and target parameters. Two distinct regimes have been identified, where ions are accelerated by, respectively, the laser-induced shock wave in the weakly driven regime (comparatively low laser intensity) and the nonlinear solitary wave in the strongly driven regime (comparatively high laser intensity). Two-dimensional particle-in-cell simulations show that quasi-monoenergetic proton beams with a peak energy of 94.6 MeV and an energy spread 15.8% are obtained by intense laser pulses at intensity I{sub 0} = 3 × 10{sup 20 }W/cm{sup 2} and pulse duration τ = 0.5 ps in the strongly driven regime, which is more advantageous than that got in the weakly driven regime. In addition, 233 MeV proton beams with narrow spread can be produced by extending τ to 1.0 ps in the strongly driven regime.

PS Control Room

CERN Multimedia

CERN PhotoLab

1963-01-01

The good old PS Control Room, all manual. For each parameter, a knob or a button to control it; for each, a light or meter or oscilloscope to monitor it; carefully written pages serve as the data bank; phones and intercom for communication. D.Dekkers is at the microphone, M.Valvini sits in front.

View into the cage of the 520 keV preaccelerator of the PS Linac 1

CERN Multimedia

1974-01-01

The "open pill box" (in the background at the left) contains the ion source, where for many years all protons accelerated at CERN were "born". It is directly attached to the acceleration column where the protons pass from 520 kV to earth potential. The "electronics platform" (big metal structure on insulating pillars in the middle of the picture, for details see 7403120 and 7403071X) contains all the equipment that has to be at the same potential as the source itself. The smaller metal box in the foreground is part of the "bouncer", which compensated the voltage drop during acceleration of a proton pulse. The high voltage generator (not included in this photo)was originally a Cockcroft-Walton column. In 1973 it was replaced by a Sames generator (see 7403074X). Visible at the bottom right of the picture is the conductor from the "Sames". The "old" 50 MeV Linac 1, the original PS injector built in the 1950s, was (since 1976) replaced by a new 50 keV linac (Linac 2). It had a 750 keV "Cockcroft-Walton" pre-injec...

Prognostic significance of cytosolic pS2 content in ovarian tumors

International Nuclear Information System (INIS)

Raigoso, P.; Allende, T.; Zeidan, N.; Llana, B.; Bernardo, L.; Roiz, C.; Tejuca, S.; Vazquez, J.; Lamelas, M.L.

2002-01-01

Aim: pS2 is an estrogen regulated peptide which has been associated with a good prognosis an with a more favorable response to treatment in breast cancer patients. In ovarian tumors, the expression of pS2 was demonstrated at both mRNA and protein levels. In addition, it has been showed significant association of pS2 with mucinous differentiation or well differentiation grade of the tumors. However, it is little know about the prognostic significance of the pS2 content in ovarian carcinomas. The aims of the present work were to analyze the cytosolic pS2 content in benign and malignant ovarian tumors, its relationship with clinico-pathologic parameters, steroid receptor status, and prognostic significance. Material and Methods: We analysed the cytosolic concentrations of pS2 in 91 specimen ovarian tissues by an immunoradiometric assay (ELSA-pS2, CIS, France). The tissues were 8 normal ovaries, 43 benign tumors and 40 malignant ovarian tumors. The same ovarian tissues processed to pS2 were analyzed to Estrogen (ER) and Progesterone (PgR) Receptor status. These steroid receptors were quantified biochemically following commercial ELISA method (ABBOTT Diagnostics, Germany). The relationship between cytosolic content and clinico-pathologic factors was examined by the Mann-Whitney or Kruskall-Wallis test. Correlation between steroid receptors and pS2 content was calculated with the Spearman test. Survival curves were calculated using the Kaplan-Meier method and compared by the log-rank test. Differences were considered significant at 5% probability level. Results: pS2 could be detected in 30 cases (32.9%) with values ranged from 0.04 to 89 ng/mg prt. Only one normal ovary showed detectable levels of pS2 and there were not differences in cytosolic content between benign and malignant ovarian tumors. The pS2 levels were only associated to mucinous differentiation in both benign and malignant ovarian tumors (p=0.029 and p=0.015, respectively). Significantly higher

LEADIR-PS: the path to a safe and economic SMR

Energy Technology Data Exchange (ETDEWEB)

Hart, R.S. [Nothern Nuclear Industries Inc., Cambridge, Ontario (Canada)

2014-07-01

Northern Nuclear Industries Incorporated (N{sup 2} I{sup 2}) is developing a family of Small Modular Reactors (SMRs) called LEADIR-PS, an acronym for LEAD-cooled Integral Reactor-Passively Safe. LEADIR-PS plants under development, focused on process heat applications and the energy demands of Canada, are the LEADIR-PS100 with an output of 100 MWth and LEADIR-PS300 with an output of 300 MWth. A plant consisting of six LEADIR-PS300 reactor modules serving a common turbine-generator, called the LEADIR-PS Six-Pack, is focused on serving areas with higher energy demands. LEADIR-PS integrates the inherent safety features of the Modular High Temperature Gas Reactor and molten lead coolant in an integral pool type reactor configuration. Molten lead coolant, which boils at 1750 {sup o}C,avoids the cost of a reactor pressure vessel and high pressure/high temperature reactor coolant systems, and the safety concerns regarding pressure vessel and large capacity reactor coolant system piping rupture and precludes evaporation of the coolant. Molten lead does not chemically react with air, water, or graphite. The Gen IV+ LEADIR-PS plants are inherently/passively safe. There are no active systems required for safe shutdown and decay heat removal. Safety is assured without active or stored energy power supply, without a requirement to reposition valves or other devices and operator intervention or action. The unprecedented safety achieved by LEADIR-PS reactors avoids requirements for a large exclusion radius and demanding evacuation plan requirements. LEADIR-PS, with steam conditions of 370 {sup o}C and 12 MPa (more than twice that of water cooled reactors), can serve over 85% of the world's non-transportation process heat demands and is ideally suited to serving Combined Heat and Electricity demands and industrial parks. Energy utilization of over 95% is feasible in process heat and Combined Heat and Electricity applications. The simple robust design of LEADIR-PS plants in

Pressure Monitoring Using Hybrid fs/ps Rotational CARS

Science.gov (United States)

Kearney, Sean P.; Danehy, Paul M.

2015-01-01

We investigate the feasibility of gas-phase pressure measurements at kHz-rates using fs/ps rotational CARS. Femtosecond pump and Stokes pulses impulsively prepare a rotational Raman coherence, which is then probed by a high-energy 6-ps pulse introduced at a time delay from the Raman preparation. Rotational CARS spectra were recorded in N2 contained in a room-temperature gas cell for pressures from 0.1 to 3 atm and probe delays ranging from 10-330 ps. Using published self-broadened collisional linewidth data for N2, both the spectrally integrated coherence decay rate and the spectrally resolved decay were investigated as means for detecting pressure. Shot-averaged and single-laser-shot spectra were interrogated for pressure and the accuracy and precision as a function of probe delay and cell pressure are discussed. Single-shot measurement accuracies were within 0.1 to 6.5% when compared to a transducer values, while the precision was generally between 1% and 6% of measured pressure for probe delays of 200 ps or more, and better than 2% as the delay approached 300 ps. A byproduct of the pressure measurement is an independent but simultaneous measurement of the gas temperature.

The OMERACT psoriatic arthritis magnetic resonance imaging scoring system (PsAMRIS): definitions of key pathologies, suggested MRI sequences, and preliminary scoring system for PsA Hands

DEFF Research Database (Denmark)

Østergaard, Mikkel; McQueen, Fiona; Wiell, Charlotte

2009-01-01

This article describes a preliminary OMERACT psoriatic arthritis magnetic resonance image scoring system (PsAMRIS) for evaluation of inflammatory and destructive changes in PsA hands, which was developed by the international OMERACT MRI in inflammatory arthritis group. MRI definitions of important...... pathologies in peripheral PsA and suggestions concerning appropriate MRI sequences for use in PsA hands are also provided....

Radiation Effects on PP/PS Blends as a Model of Protection Effects by Aromatics

International Nuclear Information System (INIS)

Gluszewski, W.

2006-01-01

Polypropylene (PP) is the most popular polymer for the application in construction of medical devices, due to the hardness and temperature resistance. Unfortunately, the virgin PP is of low resistance towards ionizing radiation, already to sterilization doses and cannot be applied without additives. Another option is a blend with a second polymer, especially aromatic, and therefore polystyrene (PS) was applied. The classic case of protection in the aliphatic/aromatic system (benzene/cyclohexane in liquid or solid state) shows that the surface area and structure of the interphase is crucial for the effectiveness of energy transfer. Our blends of PP (virgin, F401 from Orlen-Olefins) with PS were prepared in a variety of ways, from mechanical blending, to radiation induced grafting. Two linac accelerators (10 MeV, 6-9 kW) were applied, with different shapes of electron beam, formed according to particular methods used for the investigation of effects; doses were 10-600 kGy. As in the classic case, the protection effect was quantisized from the curve of the effect vs 0-100% PP, 100-0 % PS. Main recognition of the protection effect has been done by the diffused reflection spectroscopy (DRS) developed in our Laboratory for the application to irradiated polymers. The dependence of intensity of bands in the DRS spectrum, attributed to keton groups, which are final products of oxidation, shows clearly the protection effect of PP, executed by PS. The second method of observation of radiation effects is gas chromatography (GC), applied for irradiation products analysis. The maximum sensitivity has been achieved using the instrument type GC 2014 by Shimadzu, with thermal conductivity detector, column packed with molecular sieves 5A. Radiation induced formation of gaseous produced at ambient and lower temperatures is unique in the field of chemistry of polymers. There is no form of energy, except ionizing radiation, to cause chemical reactions to produce a wide spectrum of low

Energy and expectation values of the PsH system

International Nuclear Information System (INIS)

Mitroy, J.

2006-01-01

Close to converged energies and expectation values for PsH are computed using a ground state wave function consisting of 1800 explicitly correlated gaussians. The best estimate of the Ps ∞ H energy was -0.789 196 740 hartree which is the lowest variational energy to date. The 2γ annihilation rate for Ps ∞ H was 2.471 78x10 9 s -1

Experimental and Numerical Investigation of Compact Dielectric Wakefield Accelerators

Science.gov (United States)

2016-03-01

macroparticles. Additionally the laser is chosen to have a transverse rms spot size of σc = 0.8 mm and rms duration of σt = 1 ps. A solenoidal lens is...photocathode laser . . . . . . . . . . 24 3.3 Experimental realization of a linearly-ramped bunch with a multifrequency linac... laser . Our approach toward the development of a compact beam-driven accelerator consists of four main components depicted in Fig. 1. The production of

Trapping and accumulation of positrons from a pulsed beam produced by a linear accelerator for gravitational interaction of antimatter study

International Nuclear Information System (INIS)

Grandemange, Pierre

2013-01-01

The Gravitational Behaviour of Anti-hydrogen at Rest experiment - GBAR - is designed to perform a direct measurement of the weak equivalence principle on antimatter by measuring the acceleration (g-bar) of anti-hydrogen atoms in free fall. Its originality is to produce H-bar + ions and use sympathetic cooling to achieve μK temperature. H-bar + ions are produced by the reactions: p-bar + Ps → H-bar + e - , and H-bar + Ps → H-bar + + e - , where p-bar is an antiproton, Ps stands for positronium (the bound-state of a positron and an electron), H-bar is the anti-hydrogen and H-bar + the anti-ion associated. To produce enough Ps atoms, 2*10 10 positrons must be impinged on a porous SiO 2 target within 100 ns. Such an intense flux requires the accumulation (collection and cooling) of the positrons in a particle trap. This thesis describes the injector being commissioned at CEA Saclay for GBAR. It consists of a Penning-Malmberg trap (moved from RIKEN) fed by a slow positron beam. A 4.3 MeV linear accelerator shooting electrons on a tungsten target produces the pulsed positron beam, which is moderated by a multi-grid tungsten moderator. The slow positron flux is 10 4 e + /pulse, or 2*10 6 e + /s at 200 Hz. This work presents the first ever accumulation of low-energy positrons produced by an accelerator (rather than a radioactive source) and their cooling by a prepared reservoir of 2*10 10 cold electrons. (author) [fr

Demonstration of two-beam acceleration in CTF II

CERN Document Server

Bossart, Rudolf; Carron, G; Chanudet, M; Chautard, F; Delahaye, J P; Godot, J C; Hutchins, S; Kamber, I; Martínez, C; Suberlucq, Guy; Tenenbaum, P G; Thorndahl, L; Valentini, M; Wilson, Ian H; Wuensch, Walter

1999-01-01

The second phase of the Compact LInear Collider (CLIC) Test Facility (CTF II) at CERN has demon-strated the feasibility of two-beam acceleration at 30 GHz using a high-charge drive beam, running paral lel to the main beam, as the RF power source. To date accelerating gradients of 59 MV/m at 30 GHz have been achieved. In CTF II, the two beams are generated by 3 GHz RF photo-injectors and are acceler ated in 3 GHz linacs, before injection into the 30 GHz modules. The drive beam linac has to accelerate a 16 ns long train of 48 bunches, each with a nominal charge of 13.4 nC. To cope with the very su bstantial beam-loading special accelerating structures are used (running slightly off the bunch repetition frequency). A magnetic chicane compresses the bunches to less than 5 ps fwhm, this is needed for efficient 30 GHz power generation. The 30 GHz modules are fully-engineered representative sections of CLIC, they include a 30 GHz decelerator for the drive beam, a 30 GHz accelerator for the main beam, high resolution...

Laser-driven ion acceleration: methods, challenges and prospects

Science.gov (United States)

Badziak, J.

2018-01-01

The recent development of laser technology has resulted in the construction of short-pulse lasers capable of generating fs light pulses with PW powers and intensities exceeding 1021 W/cm2, and has laid the basis for the multi-PW lasers, just being built in Europe, that will produce fs pulses of ultra-relativistic intensities ~ 1023 - 1024 W/cm2. The interaction of such an intense laser pulse with a dense target can result in the generation of collimated beams of ions of multi-MeV to GeV energies of sub-ps time durations and of extremely high beam intensities and ion fluencies, barely attainable with conventional RF-driven accelerators. Ion beams with such unique features have the potential for application in various fields of scientific research as well as in medical and technological developments. This paper provides a brief review of state-of-the art in laser-driven ion acceleration, with a focus on basic ion acceleration mechanisms and the production of ultra-intense ion beams. The challenges facing laser-driven ion acceleration studies, in particular those connected with potential applications of laser-accelerated ion beams, are also discussed.

Emission properties of porphyrin compounds in new polymeric PS:CBP host

Science.gov (United States)

Jafari, Mohammad Reza; Bahrami, Bahram

2015-06-01

In this study, a device with fundamental structure of ITO/PEDOT:PSS (60 nm)/PS:CBP (70 nm)/Al (150 nm) was fabricated. The electroluminescence spectrum of device designated a red shift rather than PS:CBP photoluminescence spectra. It can be suggested that the electroplex emission occurs at PS:CBP interface. By following this step, red light-emitting devices using porphyrin compounds as a red dopant in a new host material PS:CBP with a configuration of ITO/PEDOT:PSS (60 nm)/PS:CBP:porphyrin compounds(70 nm)/Al (150 nm) have been fabricated and investigated. The electroluminescent spectra of the porphyrin compounds were red-shifted as compared with the PS:CBP blend. OLED devices based on doping 3,4PtTPP and TPPNO2 in PS:CBP showed purer red emission compared with ZnTPP and CoTPP doped devices. We believe that the electroluminescence performance of OLED devices based on porphyrin compounds depends on overlaps between the absorption of the porphyrin compounds and the emission of PS:CBP.

Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease.

Directory of Open Access Journals (Sweden)

Naoki Yahata

Full Text Available BACKGROUND: Alzheimer's disease (AD is a neurodegenerative disorder that causes progressive memory and cognitive decline during middle to late adult life. The AD brain is characterized by deposition of amyloid β peptide (Aβ, which is produced from amyloid precursor protein by β- and γ-secretase (presenilin complex-mediated sequential cleavage. Induced pluripotent stem (iPS cells potentially provide an opportunity to generate a human cell-based model of AD that would be crucial for drug discovery as well as for investigating mechanisms of the disease. METHODOLOGY/PRINCIPAL FINDINGS: We differentiated human iPS (hiPS cells into neuronal cells expressing the forebrain marker, Foxg1, and the neocortical markers, Cux1, Satb2, Ctip2, and Tbr1. The iPS cell-derived neuronal cells also expressed amyloid precursor protein, β-secretase, and γ-secretase components, and were capable of secreting Aβ into the conditioned media. Aβ production was inhibited by β-secretase inhibitor, γ-secretase inhibitor (GSI, and an NSAID; however, there were different susceptibilities to all three drugs between early and late differentiation stages. At the early differentiation stage, GSI treatment caused a fast increase at lower dose (Aβ surge and drastic decline of Aβ production. CONCLUSIONS/SIGNIFICANCE: These results indicate that the hiPS cell-derived neuronal cells express functional β- and γ-secretases involved in Aβ production; however, anti-Aβ drug screening using these hiPS cell-derived neuronal cells requires sufficient neuronal differentiation.

Chemotherapy and quality of life in NSCLC PS 2 patients

DEFF Research Database (Denmark)

Helbekkmo, Nina; Strøm, Hans H; Sundstrøm, Stein H

2009-01-01

, fatigue, dyspnea, sleeping problems and appetite loss in comparison to the PS 0/1 group. CONCLUSIONS: PS 2 NSCLC patients seem to achieve valuable HRQOL benefits from platinum-based combination therapy. Prospective clinical studies with predefined HRQOL outcomes in PS 2 patients are needed to confirm...

Production of high power microwaves for particle acceleration with an FEL bunched electron beam

CERN Document Server

Gardelle, J; Marchese, G; Padois, M; Rullier, J L; Donohue, J T

1999-01-01

Among the studies in the framework of high gradient linear electron-positron collider research, the Two-Beam Accelerator (TBA) is a very promising concept, and two projects are in progress, the Compact Linear Collider project at CERN (W. Schnell, Report no. CERN SL/92-51 and CLIC note 184; K. Huebner, CERN/PS 92-43, CLIC note 176; S. Van der Meer, CERN/PS 89-50, CLIC note 97.) and the Relativistic Klystron-TBA project at LBNL (Technical Review Committee, International Linear Collider Technical Review Committee Report 1995, SLAC-R-95-471, 1995). In a TBA an extremely intense low-energy electron beam, called the drive beam, is bunched at the desired operating frequency, and upon passing through resonant cavities generates radio-frequency power for accelerating the main beam. Among the different approaches to the production of a suitable drive beam, the use of an FEL has been proposed and is under active study at CEA/CESTA.

First radioactive ions charge bred in REXEBIS at the REX-ISOLDE accelerator

CERN Document Server

Wolf, B H; Fostner, O; Wenander, F; Ames, F; Reisinger, K; Liljeby, L; Skeppstedt, Ö; Jonson, B; Nyman, G H

2003-01-01

REXEBIS is the charge breeder of the REX-ISOLDE post accelerator. The radioactive 1$^{+}$ ions produced at ISOLDE are accumulated, phase-space cooled and bunched in the REXTRAP, and thereafter injected into the EBIS with an energy up to 60 keV. The REXEBIS produced the first charge bred ions in August 2001 and has been running nearly non-stop during September to December 2001. It has delivered stable $^{39}$K$^{10+}$ and $^{23}$Na$^{6+}$ beams generated in the ion source in front of REXTRAP with a Na$^{7+}$ current exceeding 70 pA (6x10$^{7}$ p/s). Stable $^{27}$Al$^{7+}$ and $^{23}$Na$^{6+}$ from ISOLDE and also the first radioactive $^{26}$Na$^{7+}$ and $^{24}$Na$^{7+}$ beams (just 5x10$^{5}$ p/s) have been charge bred and accelerated for tests of the experimental setup. Despite some problems with the electron gun, which had one breakdown after about 1500 hours of operation and displays slow changes of the emission conditions, the EBIS is working remarkably stable (24 hours / 7 days a week). We will report ...

PS Main Control Room (partial view)

CERN Multimedia

1974-01-01

Jean-Pierre Potier (turning buttons) and Bertran Frammery (telephoning) on shift. The 26 GeV Synchrotron and later also its related machines (Linacs 1,2,3; PS-Booster; LEP-Injector Linacs and Electron-Positron Accumulator; Antiproton Accumulator, Antiproton Collector, Low Energy Antiproton Ring and more recently Antiproton Decelerator) were all controlled from the PS control room situated on the Meyrin site. The SPS and LEP were controlled from a separat control centre on the Prevessin site. In 2005 all controls were transferred to the Prevessin centre.

The impact of the ISR on accelerator physics and technology

International Nuclear Information System (INIS)

Bryant, P J

2012-01-01

The ISR (Intersecting Storage Rings) were two intersecting proton synchrotron rings each with a circumference of 942 m and eight-fold symmetry that were operational for 13 years from 1971 to 1984. The CERN PS injected 26 GeV/c proton beams into the two rings that could accelerate up to 31.4 GeV/c. The ISR worked for physics with beams of 30-40 A over 40-60 hours with luminosities in its superconducting low-β insertion of 1031-1032 cm-2 s-1. The ISR demonstrated the practicality of collider beam physics while catalysing a rapid advance in accelerator technologies and techniques. (author)

Experimental and theoretical investigation of high gradient acceleration

International Nuclear Information System (INIS)

Wurtele, J.S.; Bekefi, G.; Chen, C.; Chen, S.C.; Temkin, R.J.

1993-01-01

This report contains a technical progress summary of the research conducted under the auspices of DOE Grant No. DE-AC02-91-ER40648, ''Experimental and Theoretical Investigations of High Gradient Acceleration''. This grant supports three research tasks: Task A consists of the design, fabrication and testing of a 17GHz RF photocathode gun, which can produce 2ps electron pulses with up to 1nC of charge at 2MeV energy and at a 1OHz repetition rate. Task B supports the testing of high gradient acceleration at 33GHz structure, and Task C comprises theoretical investigations, both in support of the experimental tasks and on critical physics issues for the development of high energy linear colliders

Beyond iPS!

Directory of Open Access Journals (Sweden)

Editorial

2012-01-01

Full Text Available It’s undoubtedly a jubilant moment for scientists and clinicians working in the stem cell arena as Prof. Gurdon and Prof. Shinya Yamanaka have been chosen for the Nobel Prize in Physiology & Medicine this year. The mystery of cell biology is something unfathomable and probably the work of this duo as well as the other scientists, who have put their hands on in- vitro de-differentiation have opened our eyes to a new window or a new paradigm in cell biology. The iPS invention has brought a lot of hope in terms of potential direct benefits to treat several diseases, which have no definite options at the moment. But, we envisage that several spin-offs could come out of this invention and one very significant spin-off finding recently witnessed is the finding by Prof. Masaharu Seno and his team of researchers at the Okayama University, Japan (Chen L, et al. 2012, PLoS ONE 7(4:e33544.doi:10.1371/journal.pone.0033544. According to Prof. Seno, mouse iPS cells (miPS when cultured in the conditioned medium derived from cancer cell lines, differentiate into cancer stem cells (CSCs. While differentiating into CSCs, they do retain the potential to develop endothelial progenitor cells. Several questions arise here: 1.Are these miPS derived CSCs really pluripotent, even if the terminal differentiation destined to specific phenotypes? 2.Shouldn’t the Cancer Stem Cells be termed as cancer progenitor cells, as till date they are considered to be producing only cancer cells but not pluripotent to yield other types of normal tissues? The spin-offs could be infinite as the process of differentiation and de-differentiation happening due to trillions of signals and pathways, most still remaining not-so-well understood. A special mention should be made to Prof. Shinya Yamanaka as he has several sterling qualities to be a role-model for budding scientists. Apart from his passion for science, which made him shift his career from orthopedics to a cell biologist, his

Accelerator complex for a radioactive ion beam facility at ATLAS

International Nuclear Information System (INIS)

Nolen, J.A.

1995-01-01

Since the superconducting heavy ion linac ATLAS is an ideal post-accelerator for radioactive beams, plans are being developed for expansion of the facility with the addition of a driver accelerator, a production target/ion source combination, and a low q/m pre-accelerator for radioactive ions. A working group including staff from the ANL Physics Division and current ATLAS users are preparing a radioactive beam facility proposal. The present paper reviews the specifications of the accelerators required for the facility

Caracterização viscosimétrica de nanocompósitos híbridos PS/POSS Viscometric characterization of PS/POSS hybrid nanocomposites

Directory of Open Access Journals (Sweden)

Otávio Bianchi

2012-01-01

Full Text Available Nanocompósitos híbridos de poliestireno (PS e poliedros oligoméricos silsesquioxanos (POSS com diferentes composições e graus de hibridização foram obtidos por processamento reativo no estado fundido utilizando-se peróxido de dicumila (DCP como iniciador, na presença ou não de estireno como agente de transferência de radical. Os materiais foram caracterizados viscosimetricamente por cromatografia de permeação em gel (GPC usando detecção tripla por espalhamento de luz, viscosimetria e índice de refração. As amostras PS/POSS processadas com estireno apresentaram maiores valores de massa molar ponderal média (Mw e menores valores de polidispersão (Mw/Mn, devido ao maior grau de conversão da reação de hibridização do PS-POSS (28-40% e do menor grau de degradação (cisão das cadeias do PS, quando comparadas com amostras PS/POSS processadas sem estireno nas quais o grau de conversão ficou em torno de 24-28%. Para os sistemas PS e PS/POSS em solução com THF, os parâmetros da equação de Mark-Houwink-Sakurada (MHS, α ≅ 0,7 e log K ≅ -3,5 a -3,9 e os valores dos parâmetros de interação polímero-solvente, χij ≅ 0,49, não apresentaram diferenças significativas com relação aos tamanhos moleculares. Por outro lado, essas diferenças de tamanhos moleculares foram caracterizadas por uma função cumulativa da fração mássica de cadeias em função da distância média quadrática entre pontas de cadeia (0½.Polystyrene (PS and polyhedral oligomeric silsesquioxanes (POSS hybrid nanocomposites with different compositions were obtained by reactive melt processing using dicumyl peroxide (DCP as initiator in the presence or absence of styrene as radical transfer agent. The materials were characterized by viscosimetry by means of gel permeation chromatography (GPC using triple-detector: light scattering, viscometer and refractive index. PS/POSS samples processed with styrene showed higher weight average molecular

Community Petascale Project for Accelerator Science and Simulation: Advancing Computational Science for Future Accelerators and Accelerator Technologies

Energy Technology Data Exchange (ETDEWEB)

Spentzouris, P.; /Fermilab; Cary, J.; /Tech-X, Boulder; McInnes, L.C.; /Argonne; Mori, W.; /UCLA; Ng, C.; /SLAC; Ng, E.; Ryne, R.; /LBL, Berkeley

2011-11-14

The design and performance optimization of particle accelerators are essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC-1 Accelerator Science and Technology project, the SciDAC-2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modelling. ComPASS is providing accelerator scientists the tools required to enable the necessary accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multiphysics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R&D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors. ComPASS is in the first year of executing its plan to develop the next-generation HPC accelerator modeling tools. ComPASS aims to develop an integrated simulation environment that will utilize existing and new accelerator physics modules with petascale capabilities, by employing modern computing and solver technologies. The ComPASS vision is to deliver to accelerator scientists a virtual accelerator and virtual prototyping modeling environment, with the necessary multiphysics, multiscale capabilities. The plan for this development includes delivering accelerator modeling applications appropriate for each stage of the ComPASS software evolution. Such applications are already being used to address challenging problems in accelerator design and optimization. The ComPASS organization

Handling and Transport of Oversized Accelerator Components and Physics Detectors

CERN Document Server

Prodon, S; Guinchard, M; Minginette, P

2006-01-01

For cost, planning and organisational reasons, it is often decided to install large pre-built accelerators components and physics detectors. As a result surface exceptional transports are required from the construction to the installation sites. Such heavy transports have been numerous during the LHC installation phase. This paper will describe the different types of transport techniques used to fit the particularities of accelerators and detectors components (weight, height, acceleration, planarity) as well as the measurement techniques for monitoring and the logistical aspects (organisation with the police, obstacles on the roads, etc). As far as oversized equipment is concerned, the lowering into the pit is challenging, as well as the transport in tunnel galleries in a very scare space and without handling means attached to the structure like overhead travelling cranes. From the PS accelerator to the LHC, handling systems have been developed at CERN to fit with these particular working conditions. This pap...

The coat protein complex II, COPII, protein Sec13 directly interacts with presenilin-1

International Nuclear Information System (INIS)

Nielsen, Anders Lade

2009-01-01

Mutations in the human gene encoding presenilin-1, PS1, account for most cases of early-onset familial Alzheimer's disease. PS1 has nine transmembrane domains and a large loop orientated towards the cytoplasm. PS1 locates to cellular compartments as endoplasmic reticulum (ER), Golgi apparatus, vesicular structures, and plasma membrane, and is an integral member of γ-secretase, a protein protease complex with specificity for intra-membranous cleavage of substrates such as β-amyloid precursor protein. Here, an interaction between PS1 and the Sec13 protein is described. Sec13 takes part in coat protein complex II, COPII, vesicular trafficking, nuclear pore function, and ER directed protein sequestering and degradation control. The interaction maps to the N-terminal part of the large hydrophilic PS1 loop and the first of the six WD40-repeats present in Sec13. The identified Sec13 interaction to PS1 is a new candidate interaction for linking PS1 to secretory and protein degrading vesicular circuits.

The coat protein complex II, COPII, protein Sec13 directly interacts with presenilin-1

Energy Technology Data Exchange (ETDEWEB)

Nielsen, Anders Lade, E-mail: aln@humgen.au.dk [Department of Human Genetics, The Bartholin Building, University of Aarhus, DK-8000 Aarhus C (Denmark)

2009-10-23

Mutations in the human gene encoding presenilin-1, PS1, account for most cases of early-onset familial Alzheimer's disease. PS1 has nine transmembrane domains and a large loop orientated towards the cytoplasm. PS1 locates to cellular compartments as endoplasmic reticulum (ER), Golgi apparatus, vesicular structures, and plasma membrane, and is an integral member of {gamma}-secretase, a protein protease complex with specificity for intra-membranous cleavage of substrates such as {beta}-amyloid precursor protein. Here, an interaction between PS1 and the Sec13 protein is described. Sec13 takes part in coat protein complex II, COPII, vesicular trafficking, nuclear pore function, and ER directed protein sequestering and degradation control. The interaction maps to the N-terminal part of the large hydrophilic PS1 loop and the first of the six WD40-repeats present in Sec13. The identified Sec13 interaction to PS1 is a new candidate interaction for linking PS1 to secretory and protein degrading vesicular circuits.

1974 view into the cage of the 520 keV preaccelerator of the PS Linac 1

CERN Multimedia

1974-01-01

The "open pill box" (in the background at the left) contains the ion source, where for many years all protons accelerated at CERN were "born". It is directly attached to the acceleration column where the protons pass from 520 kV to earth potential. The "electronics platform" (big metal structure on insulating pillars in the middle of the picture, for details see 7403120 and 7403071X) contains all the equipment that has to be at the same potential as the source itself. It is being admired by Helmut Haseroth and Jean Luc Vallet (during servicing). The smaller metal box in the foreground is part of the "bouncer" which compensated the voltage drop during acceleration of a proton pulse. The high voltage supply (not included in this photo) was originally a Cockcroft-Walton generator. In 1973 it was replaced by a Sames generator (see 7403074X). The "old" 50 MeV Linac 1, the original PS injector built in the 1950s, was (since 1976) replaced by a new 50 MeV linac (Linac 2). It had a 750 keV "Cockcroft-Walton" (see 760...

Structure and function of complex carbohydrates active in regulating plant-microbe interactions

Energy Technology Data Exchange (ETDEWEB)

Albersheim, P; Darvill, A G; McNeil, M

1981-01-01

A key regulatory role of complex carbohydrates in the interactions between plants and microbes has been established. The complex carbohydrates act as regulatory molecules or hormones in that the carbohydrates induce de novo protein synthesis in receptive cells. The first complex carbohydrate recognized to possess such regulatory properties is a polysaccharide (PS) present in the walls of fungi. Hormonal concentrations of this PS elicit plant cells to accumulate phytoalexins (antibiotics). More recently we have recognized that a PS in the walls of growing plant cells also elicits phytoalexin accumulation; microbes and viruses may cause the release of active fragments of this endogenous elicitor. Another PS in plant cell walls is the Proteinase Inhibitor Inducing Factor (PIIF). This hormone appears to protect plants by inducing synthesis in plants of proteins which specifically inhibit digestive enzymes of insects and bacteria. Glycoproteins secreted by incompatible races (races that do not infect the plant) of a fungal pathogen of soybeans protect seedlings from attack by compatible races. Glycoproteins from compatible races do not protect the seedlings. The acidic PS secreted by the nitrogen-fixing rhizobia appear to function in the infection of legumes by the rhizobia. W.D. Bauer and his co-workers have evidence that these PS are required for the development of root hairs capable of being infected by symbiont rhizobia. Current knowledge of the structures of these biologically active complex carbohydrates will be presented.

Exact PsTd invariant and PsTd symmetric breaking solutions, symmetry reductions and Bäcklund transformations for an AB-KdV system

Science.gov (United States)

Jia, Man; Lou, Sen Yue

2018-05-01

In natural and social science, many events happened at different space-times may be closely correlated. Two events, A (Alice) and B (Bob) are defined as correlated if one event is determined by another, say, B = f ˆ A for suitable f ˆ operators. A nonlocal AB-KdV system with shifted-parity (Ps, parity with a shift), delayed time reversal (Td, time reversal with a delay) symmetry where B =Ps ˆ Td ˆ A is constructed directly from the normal KdV equation to describe two-area physical event. The exact solutions of the AB-KdV system, including PsTd invariant and PsTd symmetric breaking solutions are shown by different methods. The PsTd invariant solution show that the event happened at A will happen also at B. These solutions, such as single soliton solutions, infinitely many singular soliton solutions, soliton-cnoidal wave interaction solutions, and symmetry reduction solutions etc., show the AB-KdV system possesses rich structures. Also, a special Bäcklund transformation related to residual symmetry is presented via the localization of the residual symmetry to find interaction solutions between the solitons and other types of the AB-KdV system.

W-band accelerator study in KEK

International Nuclear Information System (INIS)

Zhu Xiongwei; Nakajima, Kazuhisa

2001-01-01

In this paper, we summarize the W-band accelerator study in KEK. We present a design study on W-Band photocathode RF gun which is capable of generating and accelerating 300 pC electron bunch. The design system is made up of 91.392 GHz photocathode RF gun and 91.392 GHz traveling wave linac cells. Based on the numerical simulation using SUPERFISH and PARMELA and the conventional RF linac scaling law, the design will produce 300 pC at 1.74 MeV with bunch length 0.72 ps and normalized transverse emittance 0.55 mm mrad. We study the beam dynamics in high frequency and high gradient; due to the high gradient, the pondermotive effect plays an important role in beam dynamics; we found the pondermotive effect still exist with only the fundamental space harmonics (synchrotron mode) due to the coupling of the transverse and longitudinal motion

Ultrafast energy transfer in dansylated POPAM--eosin complexes

Science.gov (United States)

Aumanen, Jukka; Lehtovuori, Viivi; Werner, Nicole; Richardt, Gabriele; van Heyst, Jeroen; Vögtle, Fritz; Korppi-Tommola, Jouko

2006-12-01

Excitation energy transfer (EET) in dendritic host-guest complexes has been studied. Three generations G2, G3 and G4 of dansyl substituted poly(propyleneamine) dendrimers (POPAM) were complexed with a fluorescent dye eosin in chloroform solution. Arrival of excitation from dansyls to eosin was monitored by femtosecond transient absorption spectroscopy. EET rates from the dansyls to eosin(s) are characterised by two time constants 1 ps and 6 ps independent of dendrimer generation. Relaxation processes in eosin were clearly faster when complexed with dendrimer than in solution. As several eosins are bound to G3 and G4 dendrimers, besides host-guest interaction, also eosin-eosin interactions may contribute to the faster relaxation observed in these complexes.

Physics design of an accelerator for an accelerator-driven subcritical system

Directory of Open Access Journals (Sweden)

Zhihui Li

2013-08-01

Full Text Available An accelerator-driven subcritical system (ADS program was launched in China in 2011, which aims to design and build an ADS demonstration facility with the capability of more than 1000 MW thermal power in multiple phases lasting about 20 years. The driver linac is defined to be 1.5 GeV in energy, 10 mA in current and in cw operation mode. To meet the extremely high reliability and availability, the linac is designed with much installed margin and fault tolerance, including hot-spare injectors and local compensation method for key element failures. The accelerator complex consists of two parallel 10-MeV injectors, a joint medium-energy beam transport line, a main linac, and a high-energy beam transport line. The superconducting acceleration structures are employed except for the radio frequency quadrupole accelerators (RFQs which are at room temperature. The general design considerations and the beam dynamics design of the driver linac complex are presented here.

Research project on accelerator-driven subcritical system using FFAG accelerator and Kyoto University critical assembly

International Nuclear Information System (INIS)

Mishima, Kaichiro; Unesaki, Hironobu; Misawa, Tsuyoshi; Tanigaki, Minoru; Mori, Yoshiharu; Shiroya, Seiji; Inoue, Makoto; Ishi, Y.; Fukumoto, Shintaro

2005-01-01

The KART (Kumatori Accelerator-driven Reactor Test facility) project started in Research Reactor Institute, Kyoto University in fiscal year 2002 with the grant by the Japanese Ministry of Education, Culture, Sports, Science and Technology. The purpose of this research project is to demonstrate the basis feasibility of accelerator driven system (ADS), studying the effect of incident neutron energy on the effective multiplication factor in a subcritical nuclear fuel system. For this purpose, a variable-energy FFAG (Fixed Field Alternating Gradient) accelerator complex is being constructed to be coupled with the Kyoto University Critical Assembly (KUCA). The FFAG proton accelerator complex consists of ion-beta, booster and main rings. This system aims to attain 1 μA proton beam with energy range from 20 to 150 MeV with a repetition rate of 120 Hz. The first beam from the FFAG complex is expected to be available by the end of FY 2005, and the experiment on ADS with KUCA and the FFAG complex (FFAG-KUCA experiment) will start in FY 2006. Before the FFAG-KUCA experiment starts, preliminary experiments with 14 MeV neutrons are currently being performed using a Cockcroft-Walton type accelerator coupled with the KUCA. Experimental data are analyzed using continuous energy Monte-Carlo codes MVP, MCNP and MNCP-X. (author)

PS-Modules over Ore Extensions and Skew Generalized Power Series Rings

Directory of Open Access Journals (Sweden)

Refaat M. Salem

2015-01-01

Full Text Available A right R-module MR is called a PS-module if its socle, SocMR, is projective. We investigate PS-modules over Ore extension and skew generalized power series extension. Let R be an associative ring with identity, MR a unitary right R-module, O=Rx;α,δ Ore extension, MxO a right O-module, S,≤ a strictly ordered additive monoid, ω:S→EndR a monoid homomorphism, A=RS,≤,ω the skew generalized power series ring, and BA=MS,≤RS,≤, ω the skew generalized power series module. Then, under some certain conditions, we prove the following: (1 If MR is a right PS-module, then MxO is a right PS-module. (2 If MR is a right PS-module, then BA is a right PS-module.

Experimental and Theoretical Researches of a Resonator Concept of a Dielectric Wakefield Accelerator

International Nuclear Information System (INIS)

Onishchenko, I.N.; Kiselev, V.A.; Linnik, A.F.; Onishchenko, N.I.; Sotnikov, G.V.; Uskov, V.V.

2006-01-01

Wakefield excitation in a cylindrical dielectric waveguide or resonator by a regular sequence of electron bunches foe application to high-gradient particle acceleration has been investigated theoretically and experimentally using an electron linac 'ALMAZ-2' (4.5 MeV, 6.10 3 bunches of duration 60 ps and charge 0.32 nC each)

The electron accelerator for FELIX [Free Electron Laser for Infrared eXperiments

International Nuclear Information System (INIS)

Amersfoort, P.W. van; Geer, C.A.J. van der; Meer, A.F.G. van der; Bruinsma, P.J.T.; Hoekstra, R.; Kroes, F.B.; Luyckx, G.; Noomen, J.G.; Poole, M.W.; Saxon, G.

1989-01-01

The authors discuss the design of the electron accelerator for the Free Electron Laser for Infrared eXperiments (FELIX), which is meant to provide the Dutch science community with a rapidly tunable source of infrared radiation. The first stage of the project will (at least) cover the wavelength range between 8 and 80 μm. The accelerator consists of a triode with a grid modulated at 1 GHz, a 3.8-MeV buncher, and two travelling-wave S-band linac structures, with which 70-A, 3-ps bunches are accelerated to an energy between 15 and 4-5 MeV. The system has been designed to minimize the energy spread in the electron beam. 8 refs., 2 figs., 1 tab

0,01-5 MeV heavy ion accelerators

International Nuclear Information System (INIS)

Golubev, V.P.; Ivanov, A.S.; Nikiforov, S.A.; Svin'in, M.P.; Tarvid, G.V.; Troshikhin, A.G.; Fedotov, M.T.

1983-01-01

The results of development of an accelerating complex on the base of the UP-2-1 heavy ion charge exchange accelerator and IMPLANT-500 high-voltage heavy ion accelerator are given. The accelerating complex provides overlapping of the 0.01 MeV to 5 MeV energy range at accelerated beam currents of 10 -3 -10 -6 A order. The structural features of accelerators and their basic units and systems are considered. The UP-2-1 accelerator is designed for researches in the field of experimental physics and applied problem solutions. The IMPLANT-500 accelerator is designed for commercial ion-beam facilities with closed loop of silicon plate treatment

Community petascale project for accelerator science and simulation: Advancing computational science for future accelerators and accelerator technologies

International Nuclear Information System (INIS)

Spentzouris, P.; Cary, J.; McInnes, L.C.; Mori, W.; Ng, C.; Ng, E.; Ryne, R.

2008-01-01

The design and performance optimization of particle accelerators are essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC-1 Accelerator Science and Technology project, the SciDAC-2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modelling. ComPASS is providing accelerator scientists the tools required to enable the necessary accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multiphysics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R and D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors.

Compact high-current, subnanosecond electron accelerator

Energy Technology Data Exchange (ETDEWEB)

Shpak, V G; Shunajlov, S A; Ulmaskulov, M R; Yalandin, M I [Russian Academy of Sciences, Ekaterinburg (Russian Federation). Inst. of Electrophysics; Pegel, I V [Russian Academy of Sciences, Tomsk (Russian Federation). High-Current Electronics Inst.; Tarakanov, V P [Russian Academy of Sciences, Moscow (Russian Federation). High-Temperature Inst.

1997-12-31

A compact subnanosecond, high-current electron accelerator producing an annular electron beam of duration up to 300 - 400 ps, energy about 250 keV, and current up to 1 kA has been developed to study transient processes in pulsed power microwave devices. The measuring and recording techniques used to experimentally investigate the dynamics of the beam current pulse and the transformation of the electron energy during the transportation of the beam in a longitudinal magnetic field are described. The experimental data obtained are compared with the predictions of a numerical simulation. (author). 6 figs., 5 refs.

CERN Technical Training 2003: Learning for the LHC!

CERN Multimedia

2003-01-01

AXEL-2003 - Introduction to Particle Accelerators AXEL-2003 is a course given at CERN within the framework of the Technical Training Programme. The course will present an introduction to particle accelerators. Known in the past as the PS Complex Operation Course (or the "PS Shutdown Course"), and organised by the ex-PS division until last year, it is now organised as a joint venture between the AB division and Technical Training, and open to a wider CERN community. The AXEL-2003 course series is designed for technicians who are operating an accelerator, or whose work is closely linked to accelerators, but it is open to all people (technicians, engineers, physicists) interested in this field. The course does not require any prior knowledge on accelerators. However, some basic knowledge on trigonometry, matrices and differential equations, and some basic notions of magnetism would be an advantage. The course and the course supports will be in English, with questions and answers also in French. Lectures wil...

CERN Technical Training 2003: Learning for the LHC!

CERN Multimedia

2003-01-01

AXEL-2003  -  Introduction to Particle Accelerators   AXEL-2003 is a course given at CERN within the framework of the Technical Training Programme. The course will present an introduction to particle accelerators. Known in the past as the PS Complex Operation Course (or the "PS Shutdown Course"), and organised by the ex-PS division until last year, it is now organised as a joint venture between the AB division and Technical Training, and open to a wider CERN community. The AXEL-2003 course series is designed for technicians who are operating an accelerator, or whose work is closely linked to accelerators, but it is open to all people (technicians, engineers, physicists) interested in this field. The course does not require any prior knowledge on accelerators. However, some basic knowledge on trigonometry, matrices and differential equations, and some basic notions of magnetism would be an advantage. The course and the course supports will be in English, with questions and answers also in French. Lectur...

Growth acceleration and photosynthesis of the scenedesmus algae and cocconeis algae in deuterium water

International Nuclear Information System (INIS)

Liu Feng; Wang Wenqing

1998-01-01

In order to find new way to treat the radioactive tritium waste water, scenedesmus algae and cocconeis algae are cultured in medium which contains 30% (w) deuterium water. During different time, activities of photosymthesis, absorption spectrum, growth rate and low-temperature fluorescence spectrum are measured. Accelerated growth is found in the deuterium water compared to the normal water. Activities of photosynthesis show the similar result (F v /F m ) to the growth data. It is also concluded from low-temperature fluorescence spectra that algae activities in the deuterium water, which are expressed by PS I/PS II, are more sensitive than those in the normal water

Antiphosphatidylserine/prothrombin (aPS/PT) antibodies are associated with Raynaud phenomenon and migraine in primary thrombotic antiphospholipid syndrome.

Science.gov (United States)

Kopytek, M; Natorska, J; Undas, A

2018-04-01

Objectives Antibodies to phosphatidylserine/prothrombin complex (aPS/PT) detectable in sera of some patients with antiphospholipid syndrome (APS) have been shown to correlate with thrombosis. However, associations of aPS/PT antibodies with APS related disorders remain unclear. Aim To evaluate whether there are any associations between aPS/PT antibodies and Raynaud phenomenon, migraine and/or valvular lesions in primary thrombotic APS (PAPS). Methods We enrolled 67 consecutive patients (56 women) with thrombotic PAPS (VTE in 80.6%), aged 46.2 ± 13.5 years. The exclusion criteria were: acute coronary syndromes or stroke within preceding 6 months, cancer, severe comorbidities and pregnancy. The IgG and IgM aPS/PT antibodies were determined by ELISA with the cut-off of 30 units. We recorded Raynaud phenomenon, migraine and valvular lesions. Results Positive IgM or/and IgG aPS/PT antibodies were observed in 29 patients (43.3%), with a higher prevalence of IgM antibodies ( n = 27, 40.3%) compared with IgG isotype ( n = 12, 17.9%, p = 0.014). aPS/PT antibodies were observed most commonly in patients with triple aPL ( n = 12, 85.7%) compared with those with double ( n = 5, 35.7%) or single aPL antibodies (n = 12, 30.8%, p = 0.03), with no association with demographics, the ANA titre, the type of thrombotic events or medications. Raynaud phenomenon, migraine and valvular lesions were observed in 15% ( n = 10), 30% ( n = 20) and 18% ( n = 12) of the patients, respectively. Raynaud phenomenon and migraine, but not valvular lesions, were markedly more frequent in PAPS patients presenting with positive aPS/PT antibodies ( n = 10, 34.5% vs. n = 0, 0%; p = 0.0001). Conclusions In PAPS patients aPS/PT antibodies are related to the occurrence of both Raynaud phenomenon and migraine.

The neutron total cross-section measurement of 56Fe and 57Fe by using Japan Proton Accelerator Research Complex facility

International Nuclear Information System (INIS)

Kim, Eun Ae; Shvetsov, Valery; Cho, Moo Hyun; Won, Nam Kung; Kim, Kwang Soo; Yang, Sung Chul; Lee, Man Woo; Kim, Guin Yun; Yi, Kyoung Rak; Choi, Hong Yub; Ro, Tae Ik; Mizumoto, Motoharu; Katabuchi, Tatsuya; Igashira, Masayuki

2012-01-01

The measurement of neutron cross section using Time-Of-Flight (TOF) method gives significant information for the nuclear data research. In the present work, the neutron total cross section of 56 Fe and 57 Fe has been measured in the energy range between 10 eV and 100 keV by using the neutron beam produced from 3-GeV proton synchrotron accelerator. The 3-GeV proton synchrotron accelerator is located at Japan Proton Accelerator Research Complex (J-PARC) facility in Tokai village. In this study, the neutron total cross section data measured by 6 Li glass scintillator detector was compared with the evaluated values of ENDF/B-VII.0

How to Commission, Operate and Maintain a Large Future Accelerator Complex From Far Remote Sites

International Nuclear Information System (INIS)

Phinney, Nan

2001-01-01

A study on future large accelerators [1] has considered a facility, which is designed, built and operated by a worldwide collaboration of equal partner institutions, and which is remote from most of these institutions. The full range of operation was considered including commissioning, machine development, maintenance, trouble shooting and repair. Experience from existing accelerators confirms that most of these activities are already performed remotely. The large high-energy physics experiments and astronomy projects, already involve international collaborations of distant institutions. Based on this experience, the prospects for a machine operated remotely from far sites are encouraging. Experts from each laboratory would remain at their home institution but continue to participate in the operation of the machine after construction. Experts are required to be on site only during initial commissioning and for particularly difficult problems. Repairs require an on-site non-expert maintenance crew. Most of the interventions can be made without an expert and many of the rest resolved with remote assistance. There appears to be no technical obstacle to controlling an accelerator from a distance. The major challenge is to solve the complex management and communication problems

How to Commission, Operate and Maintain a Large Future Accelerator Complex From Far Remote Sites

Energy Technology Data Exchange (ETDEWEB)

Phinney, Nan

2001-12-07

A study on future large accelerators [1] has considered a facility, which is designed, built and operated by a worldwide collaboration of equal partner institutions, and which is remote from most of these institutions. The full range of operation was considered including commissioning, machine development, maintenance, troubleshooting and repair. Experience from existing accelerators confirms that most of these activities are already performed 'remotely'. The large high-energy physics experiments and astronomy projects, already involve international collaborations of distant institutions. Based on this experience, the prospects for a machine operated remotely from far sites are encouraging. Experts from each laboratory would remain at their home institution but continue to participate in the operation of the machine after construction. Experts are required to be on site only during initial commissioning and for particularly difficult problems. Repairs require an on-site non-expert maintenance crew. Most of the interventions can be made without an expert and many of the rest resolved with remote assistance. There appears to be no technical obstacle to controlling an accelerator from a distance. The major challenge is to solve the complex management and communication problems.

PS1/γ-Secretase-Mediated Cadherin Cleavage Induces β-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells

Directory of Open Access Journals (Sweden)

Danielle C. Bonfim

2016-01-01

Full Text Available Bone marrow stromal cells (BMSCs are considered a promising tool for bone bioengineering. However, the mechanisms controlling osteoblastic commitment are still unclear. Osteogenic differentiation of BMSCs requires the activation of β-catenin signaling, classically known to be regulated by the canonical Wnt pathway. However, BMSCs treatment with canonical Wnts in vitro does not always result in osteogenic differentiation and evidence indicates that a more complex signaling pathway, involving cadherins, would be required to induce β-catenin signaling in these cells. Here we showed that Wnt3a alone did not induce TCF activation in BMSCs, maintaining the cells at a proliferative state. On the other hand, we verified that, upon BMSCs osteoinduction with dexamethasone, cadherins were cleaved by the PS1/γ-secretase complex at the plasma membrane, and this event was associated with an enhanced β-catenin translocation to the nucleus and signaling. When PS1/γ-secretase activity was inhibited, the osteogenic process was impaired. Altogether, we provide evidence that PS1/γ-secretase-mediated cadherin cleavage has as an important role in controlling β-catenin signaling during the onset of BMSCs osteogenic differentiation, as part of a complex signaling pathway responsible for cell fate decision. A comprehensive map of these pathways might contribute to the development of strategies to improve bone repair.

New tests to detect antiphospholipid antibodies: antiprothrombin (aPT) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies.

Science.gov (United States)

Sciascia, Savino; Khamashta, Munther A; Bertolaccini, Maria Laura

2014-05-01

Antiprothrombin antibodies have been proposed as potential new biomarkers for thrombosis and/or pregnancy morbidity in the setting of the antiphospholipid syndrome (APS). Antiprothrombin antibodies are commonly detected by ELISA, using prothrombin coated onto irradiated plates (aPT), or prothrombin in complex with phosphatidylserine (aPS/PT), as antigen. Although these antibodies can co-exist in the same patient, aPT and aPS/PT seem to belong to different populations of autoantibodies. Early research explored the role of antibodies to prothrombin as potential antigenic targets for the lupus anticoagulant (LA). To date their clinical significance is being investigated and their potential role in identifying patients at higher risk of developing thrombotic events or pregnancy morbidity is being probed.

Omega-conotoxin- and nifedipine-insensitive voltage-operated calcium channels mediate K(+)-induced release of pro-thyrotropin-releasing hormone-connecting peptides Ps4 and Ps5 from perifused rat hypothalamic slices.

Science.gov (United States)

Valentijn, K; Tranchand Bunel, D; Vaudry, H

1992-07-01

The rat thyrotropin-releasing hormone (TRH) precursor (prepro-TRH) contains five copies of the TRH progenitor sequence linked together by intervening sequences. Recently, we have shown that the connecting peptides prepro-TRH-(160-169) (Ps4) and prepro-TRH-(178-199) (Ps5) are released from rat hypothalamic neurones in response to elevated potassium concentrations, in a calcium-dependent manner. In the present study, the role of voltage-operated calcium channels in potassium-induced release of Ps4 and Ps5 was investigated, using a perifusion system for rat hypothalamic slices. The release of Ps4 and Ps5 stimulated by potassium (70 mM) was blocked by the inorganic ions Co2+ (2.6 mM) and Ni2+ (5 mM). In contrast, the stimulatory effect of KCl was insensitive to Cd2+ (100 microM). The dihydropyridine antagonist nifedipine (10 microM) had no effect on K(+)-evoked release of Ps4 and Ps5. Furthermore, the response to KCl was not affected by nifedipine (10 microM) in combination with diltiazem (1 microM), a benzothiazepine which increases the affinity of dihydropyridine antagonists for their receptor. The dihydropyridine agonist BAY K 8644, at concentrations as high as 1 mM, did not stimulate the basal secretion of Ps4 and Ps5. In addition, BAY K 8644 had no potentiating effect on K(+)-induced release of Ps4 and Ps5. The marine cone snail toxin omega-conotoxin, a blocker of both L- and N-type calcium channels had no effect on the release of Ps4 and Ps5 stimulated by potassium. Similarly, the omega-conopeptide SNX-111, a selective blocker of N-type calcium channels, did not inhibit the stimulatory effect of potassium. The release of Ps4 and Ps5 evoked by high K+ was insensitive to the non-selective calcium channel blocker verapamil (20 microM). Amiloride (1 microM), a putative blocker of T-type calcium channels, did not affect KCl-induced secretion of the two connecting peptides. Taken together, these results indicate that two connecting peptides derived from the pro-TRH, Ps

First high-power model of the annular-ring coupled structure for use in the Japan Proton Accelerator Research Complex linac

Directory of Open Access Journals (Sweden)

Hiroyuki Ao

2012-01-01

Full Text Available A prototype cavity for the annular-ring coupled structure (ACS for use in the Japan Proton Accelerator Research Complex (J-PARC linac has been developed to confirm the feasibility of achieving the required performance. This prototype cavity is a buncher module, which includes ten accelerating cells in total. The ACS cavity is formed by the silver brazing of ACS half-cell pieces stacked in a vacuum furnace. The accelerating cell of the ACS is surrounded by a coupling cell. We, therefore, tuned the frequencies of the accelerating and coupling cells by an ultraprecision lathe before brazing, taking into account the frequency shift due to brazing. The prototype buncher module was successfully conditioned up to 600 kW, which corresponds to an accelerating field that is higher than the designed field of 4.1  MV/m by 30%. We describe the frequency-tuning results for the prototype buncher module and its high-power conditioning.

Reaching for highest ion beam intensities through laser ion acceleration and beam compression

Energy Technology Data Exchange (ETDEWEB)

Schumacher, Dennis; Brabetz, Christian; Blazevic, Abel; Bagnoud, Vincent; Weih, Simon [GSI Helmholtzzentrum fuer Schwerionenforschung (Germany); Jahn, Diana; Ding, Johannes; Roth, Markus [TU Darmstadt (Germany); Kroll, Florian; Schramm, Ulrich; Cowan, Tom [Helmholtzzentrum Dresden Rossendorf (Germany); Collaboration: LIGHT-Collaboration

2016-07-01

Laser ion acceleration provides access to ion sources with unique properties. To use these capabilities the LIGHT collaboration (Laser Ion Generation Handling and Transport) was founded. The aim of this collaboration is the beam transport and manipulation of laser accelerated ions with conventional accelerator structures. Therefor a dedicated beam line has been build up at GSI Helmholtzzentrum fuer Schwerionenforschung. With this beam line the manipulation of the transversal and also the longitudinal beam parameters has been achieved. It has been shown that laser generated ion beams can be transported over more than 6 meters and pulses shorter than 300 ps can be generated at this distance. This Talk will give an overview over the recent developments and plans of the LIGHT collaboration.

Beam commissioning of the 3-GeV rapid cycling synchrotron of the Japan Proton Accelerator Research Complex

Directory of Open Access Journals (Sweden)

H. Hotchi

2009-04-01

Full Text Available The 3-GeV rapid cycling synchrotron (RCS of the Japan Proton Accelerator Research Complex (J-PARC was commissioned in October 2007, and successfully accomplished 3 GeV acceleration on October 31. Six run cycles through February 2008 were dedicated to commissioning the RCS, for which the initial machine parameter tuning and various underlying beam studies were completed. Then since May 2008 the RCS beam has been delivered to the downstream facilities for their beam commissioning. In this paper we describe beam tuning and study results following our beam commissioning scenario and a beam performance and operational experience obtained in the first commissioning phase through June 2008.

Differential expression of GSK3β and pS9GSK3β in normal human tissues: can pS9GSK3β be an epithelial marker?

Science.gov (United States)

Lee, Hojung; Ro, Jae Y

2015-01-01

Glycogen synthase kinase 3β (GSK3β) and phosphorylated GSK3β at Ser9 (pS9GSK3β) are crucial in cellular proliferation and metabolism. GSK3β and pS9GSK3β are deregulated in many diseases including tumors. Data on altered expression of GSK3β and pS9GSK3β are mainly limited to tumor tissues, thus the expression of GSK3β and pS9GSK3β in normal human tissue has been largely unknown. Thus, we examined the immunohistochemical localization of GSK3β and pS9GSK3β in human fetal and adult tissues, and also compared the expression pattern of GSK3β and pS9GSK3β with that of the CK7 and CK20. We found GSK3β expression in neurons of brain, myenteric plexus in gastrointestinal tract, squamous epithelium of skin, and mammary gland. The expression of pS9GSK3β was restricted to the epithelial cells of breast and pancreaticobiliary duct, distal nephron of kidney, gastrointestinal tract, fallopian tube, epididymis, secretory cell of prostatic gland, and umbrella cell of urinary tract. The staining pattern of pS9GSK3β and CK7 was overlapped in most organs except for gastrointestinal tract where CK7 was negative and CK20 was positive. Our results show that the expression of GSK3β may be associated with differentiation of ectodermal derived tissues and pS9GSK3β with that of epithelial cells of endodermal derived tissues in human. In addition, the expression of pS9GSK3β in the selective epithelial cells may indicate its association with secretory or barrier function of specific cells and may serve as another immunohistochemical marker for epithelial cells.

The Spallation Neutron Source accelerator system design

Science.gov (United States)

Henderson, S.; Abraham, W.; Aleksandrov, A.; Allen, C.; Alonso, J.; Anderson, D.; Arenius, D.; Arthur, T.; Assadi, S.; Ayers, J.; Bach, P.; Badea, V.; Battle, R.; Beebe-Wang, J.; Bergmann, B.; Bernardin, J.; Bhatia, T.; Billen, J.; Birke, T.; Bjorklund, E.; Blaskiewicz, M.; Blind, B.; Blokland, W.; Bookwalter, V.; Borovina, D.; Bowling, S.; Bradley, J.; Brantley, C.; Brennan, J.; Brodowski, J.; Brown, S.; Brown, R.; Bruce, D.; Bultman, N.; Cameron, P.; Campisi, I.; Casagrande, F.; Catalan-Lasheras, N.; Champion, M.; Champion, M.; Chen, Z.; Cheng, D.; Cho, Y.; Christensen, K.; Chu, C.; Cleaves, J.; Connolly, R.; Cote, T.; Cousineau, S.; Crandall, K.; Creel, J.; Crofford, M.; Cull, P.; Cutler, R.; Dabney, R.; Dalesio, L.; Daly, E.; Damm, R.; Danilov, V.; Davino, D.; Davis, K.; Dawson, C.; Day, L.; Deibele, C.; Delayen, J.; DeLong, J.; Demello, A.; DeVan, W.; Digennaro, R.; Dixon, K.; Dodson, G.; Doleans, M.; Doolittle, L.; Doss, J.; Drury, M.; Elliot, T.; Ellis, S.; Error, J.; Fazekas, J.; Fedotov, A.; Feng, P.; Fischer, J.; Fox, W.; Fuja, R.; Funk, W.; Galambos, J.; Ganni, V.; Garnett, R.; Geng, X.; Gentzlinger, R.; Giannella, M.; Gibson, P.; Gillis, R.; Gioia, J.; Gordon, J.; Gough, R.; Greer, J.; Gregory, W.; Gribble, R.; Grice, W.; Gurd, D.; Gurd, P.; Guthrie, A.; Hahn, H.; Hardek, T.; Hardekopf, R.; Harrison, J.; Hatfield, D.; He, P.; Hechler, M.; Heistermann, F.; Helus, S.; Hiatt, T.; Hicks, S.; Hill, J.; Hill, J.; Hoff, L.; Hoff, M.; Hogan, J.; Holding, M.; Holik, P.; Holmes, J.; Holtkamp, N.; Hovater, C.; Howell, M.; Hseuh, H.; Huhn, A.; Hunter, T.; Ilg, T.; Jackson, J.; Jain, A.; Jason, A.; Jeon, D.; Johnson, G.; Jones, A.; Joseph, S.; Justice, A.; Kang, Y.; Kasemir, K.; Keller, R.; Kersevan, R.; Kerstiens, D.; Kesselman, M.; Kim, S.; Kneisel, P.; Kravchuk, L.; Kuneli, T.; Kurennoy, S.; Kustom, R.; Kwon, S.; Ladd, P.; Lambiase, R.; Lee, Y. Y.; Leitner, M.; Leung, K.-N.; Lewis, S.; Liaw, C.; Lionberger, C.; Lo, C. C.; Long, C.; Ludewig, H.; Ludvig, J.; Luft, P.; Lynch, M.; Ma, H.; MacGill, R.; Macha, K.; Madre, B.; Mahler, G.; Mahoney, K.; Maines, J.; Mammosser, J.; Mann, T.; Marneris, I.; Marroquin, P.; Martineau, R.; Matsumoto, K.; McCarthy, M.; McChesney, C.; McGahern, W.; McGehee, P.; Meng, W.; Merz, B.; Meyer, R.; Meyer, R.; Miller, B.; Mitchell, R.; Mize, J.; Monroy, M.; Munro, J.; Murdoch, G.; Musson, J.; Nath, S.; Nelson, R.; Nelson, R.; O`Hara, J.; Olsen, D.; Oren, W.; Oshatz, D.; Owens, T.; Pai, C.; Papaphilippou, I.; Patterson, N.; Patterson, J.; Pearson, C.; Pelaia, T.; Pieck, M.; Piller, C.; Plawski, T.; Plum, M.; Pogge, J.; Power, J.; Powers, T.; Preble, J.; Prokop, M.; Pruyn, J.; Purcell, D.; Rank, J.; Raparia, D.; Ratti, A.; Reass, W.; Reece, K.; Rees, D.; Regan, A.; Regis, M.; Reijonen, J.; Rej, D.; Richards, D.; Richied, D.; Rode, C.; Rodriguez, W.; Rodriguez, M.; Rohlev, A.; Rose, C.; Roseberry, T.; Rowton, L.; Roybal, W.; Rust, K.; Salazer, G.; Sandberg, J.; Saunders, J.; Schenkel, T.; Schneider, W.; Schrage, D.; Schubert, J.; Severino, F.; Shafer, R.; Shea, T.; Shishlo, A.; Shoaee, H.; Sibley, C.; Sims, J.; Smee, S.; Smith, J.; Smith, K.; Spitz, R.; Staples, J.; Stein, P.; Stettler, M.; Stirbet, M.; Stockli, M.; Stone, W.; Stout, D.; Stovall, J.; Strelo, W.; Strong, H.; Sundelin, R.; Syversrud, D.; Szajbler, M.; Takeda, H.; Tallerico, P.; Tang, J.; Tanke, E.; Tepikian, S.; Thomae, R.; Thompson, D.; Thomson, D.; Thuot, M.; Treml, C.; Tsoupas, N.; Tuozzolo, J.; Tuzel, W.; Vassioutchenko, A.; Virostek, S.; Wallig, J.; Wanderer, P.; Wang, Y.; Wang, J. G.; Wangler, T.; Warren, D.; Wei, J.; Weiss, D.; Welton, R.; Weng, J.; Weng, W.-T.; Wezensky, M.; White, M.; Whitlatch, T.; Williams, D.; Williams, E.; Wilson, K.; Wiseman, M.; Wood, R.; Wright, P.; Wu, A.; Ybarrolaza, N.; Young, K.; Young, L.; Yourd, R.; Zachoszcz, A.; Zaltsman, A.; Zhang, S.; Zhang, W.; Zhang, Y.; Zhukov, A.

2014-11-01

The Spallation Neutron Source (SNS) was designed and constructed by a collaboration of six U.S. Department of Energy national laboratories. The SNS accelerator system consists of a 1 GeV linear accelerator and an accumulator ring providing 1.4 MW of proton beam power in microsecond-long beam pulses to a liquid mercury target for neutron production. The accelerator complex consists of a front-end negative hydrogen-ion injector system, an 87 MeV drift tube linear accelerator, a 186 MeV side-coupled linear accelerator, a 1 GeV superconducting linear accelerator, a 248-m circumference accumulator ring and associated beam transport lines. The accelerator complex is supported by ~100 high-power RF power systems, a 2 K cryogenic plant, ~400 DC and pulsed power supply systems, ~400 beam diagnostic devices and a distributed control system handling ~100,000 I/O signals. The beam dynamics design of the SNS accelerator is presented, as is the engineering design of the major accelerator subsystems.

Human amniotic epithelial cell feeder layers maintain human iPS cell pluripotency via inhibited endogenous microRNA-145 and increased Sox2 expression

International Nuclear Information System (INIS)

Liu, Te; Cheng, Weiwei; Huang, Yongyi; Huang, Qin; Jiang, Lizhen; Guo, Lihe

2012-01-01

Currently, human induced pluripotent stem (iPS) cells were generated from patient or disease-specific sources and share the same key properties as embryonic stem cells. This makes them attractive for personalized medicine, drug screens or cellular therapy. Long-term cultivation and maintenance of normal iPS cells in an undifferentiated self-renewing state are a major challenge. Our previous studies have shown that human amniotic epithelial cells (HuAECs) could provide a good source of feeder cells for mouse and human embryonic stem cells, or spermatogonial stem cells, but the mechanism for this is unknown. Here, we examined the effect of endogenous microRNA-145 regulation on Sox2 expression in human iPS cells by HuAECs feeder cells regulation, and in turn on human iPS cells pluripotency. We found that human IPS cells transfected with a microRNA-145 mutant expressed Sox2 at high levels, allowing iPS to maintain a high level of AP activity in long-term culture and form teratomas in SCID mice. Expression of stem cell markers was increased in iPS transfected with the microRNA-145 mutant, compared with iPS was transfected with microRNA-145. Besides, the expression of Drosha proteins of the microRNA-processor complex, required for the generation of precursor pre-miRNA, was significantly increased in human iPS cells cultured on MEF but not on HuAECs. Taken together, these results suggest that endogenous Sox2 expression may be regulated by microRNA-145 in human iPS cells with HuAECs feeder cells, and Sox2 is a crucial component required for maintenance of them in an undifferentiated, proliferative state capable of self-renewal. Highlights: ► microRNA-145 inhibits Sox2 expression in human iPS cells. ► microRNA-145 suppresses the self-renewal and pluripotency of human iPS cells. ► HuAECs regulate expression of microRNA-145 and Sox2 in human iPS cells. ► HuAECs feeder layers maintain human iPS cells pluripotency. ► HuAECs negatively regulates the synthesis of

Human amniotic epithelial cell feeder layers maintain human iPS cell pluripotency via inhibited endogenous microRNA-145 and increased Sox2 expression

Energy Technology Data Exchange (ETDEWEB)

Liu, Te, E-mail: liute79@yahoo.com [School of Environmental Science and Engineering, Donghua University, Shanghai 201620 (China); Shanghai Geriatric Institute of Chinese Medicine, Shanghai 200031 (China); Cheng, Weiwei [International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University, Shanghai 200030 (China); Huang, Yongyi [Laboratoire PROTEE, Batiment R, Universite du Sud Toulon-Var, 83957 LA GARDE Cedex (France); Huang, Qin; Jiang, Lizhen [Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031 (China); Guo, Lihe, E-mail: liute79@yahoo.com [Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031 (China)

2012-02-15

Currently, human induced pluripotent stem (iPS) cells were generated from patient or disease-specific sources and share the same key properties as embryonic stem cells. This makes them attractive for personalized medicine, drug screens or cellular therapy. Long-term cultivation and maintenance of normal iPS cells in an undifferentiated self-renewing state are a major challenge. Our previous studies have shown that human amniotic epithelial cells (HuAECs) could provide a good source of feeder cells for mouse and human embryonic stem cells, or spermatogonial stem cells, but the mechanism for this is unknown. Here, we examined the effect of endogenous microRNA-145 regulation on Sox2 expression in human iPS cells by HuAECs feeder cells regulation, and in turn on human iPS cells pluripotency. We found that human IPS cells transfected with a microRNA-145 mutant expressed Sox2 at high levels, allowing iPS to maintain a high level of AP activity in long-term culture and form teratomas in SCID mice. Expression of stem cell markers was increased in iPS transfected with the microRNA-145 mutant, compared with iPS was transfected with microRNA-145. Besides, the expression of Drosha proteins of the microRNA-processor complex, required for the generation of precursor pre-miRNA, was significantly increased in human iPS cells cultured on MEF but not on HuAECs. Taken together, these results suggest that endogenous Sox2 expression may be regulated by microRNA-145 in human iPS cells with HuAECs feeder cells, and Sox2 is a crucial component required for maintenance of them in an undifferentiated, proliferative state capable of self-renewal. Highlights: Black-Right-Pointing-Pointer microRNA-145 inhibits Sox2 expression in human iPS cells. Black-Right-Pointing-Pointer microRNA-145 suppresses the self-renewal and pluripotency of human iPS cells. Black-Right-Pointing-Pointer HuAECs regulate expression of microRNA-145 and Sox2 in human iPS cells. Black-Right-Pointing-Pointer HuAECs feeder

Motor-generator set of the PS main supply

CERN Multimedia

Photographic Service; CERN PhotoLab

1968-01-01

Already in 1964, the PS improvement programme included a new main magnet supply with more power for the longer cycles needed for slow extraction at the full energy of 26 GeV. This motor-generator set was installed in 1967 and took up service at the beginning of 1968. Regularly serviced and fitted with modern electronic regulation, it pulses the PS to this day.

Interleaving of beam lines inside the PS tunnel

CERN Multimedia

1983-01-01

View against the direction of the proton beams. The PS ring (section 26) is on the left. The injection tunnel for LEAR leaving from here has increased the trafic in this already busy area where the two Linacs and the transfer tunnel leading to the SPS, ISR and AA join the PS ring (cf. photo 7802260, 7802261, Annual Report 1981, p. 89, fig. 12).

Analysis of binding ability of two tetramethylpyridylporphyrins to albumin and its complex with bilirubin

Science.gov (United States)

Solomonov, Alexey V.; Shipitsyna, Maria K.; Vashurin, Arthur S.; Rumyantsev, Evgeniy V.; Timin, Alexander S.; Ivanov, Sergey P.

2016-11-01

An interaction between 5,10,15,20-tetrakis-(N-methyl-x-pyridyl)porphyrins, x = 2; 4 (TMPyPs) with bovine serum albumin (BSA) and its bilirubin (BR) complex was investigated by UV-Viz and fluorescence spectroscopy under imitated physiological conditions involving molecular docking studies. The parameters of forming intermolecular complexes (binding constants, quenching rate constants, quenching sphere radius etc.) were determined. It was showed that the interaction between proteins and TMPyPs occurs via static quenching of protein fluorescence and has predominantly hydrophobic and electrostatic character. It was revealed that obtained complexes are relatively stable, but in the case of TMPyP4 binding with proteins occurs better than TMPyP2. Nevertheless, both TMPyPs have better binding ability with free protein compared to BRBSA at the same time. The influence of TMPyPs on the conformational changes in protein molecules was studied using synchronous fluorescence spectroscopy. It was found that there is no competition of BR with TMPyPs for binging sites on protein molecule and BR displacement does not occur. Molecular docking calculations have showed that TMPyPs can bind with albumin via tryptophan residue in the hydrophilic binding site of protein molecule but it is not one possible interaction way.

Picosecond, single pulse electron linear accelerator

International Nuclear Information System (INIS)

Kikuchi, Riichi; Kawanishi, Masaharu

1979-01-01

The picosecond, single pulse electron linear accelerators, are described, which were installed in the Nuclear Engineering Laboratory of the University of Tokyo and in the Nuclear Radiation Laboratory of the Osaka University. The purpose of the picosecond, single pulse electron linear accelerators is to investigate the very short time reaction of the substances, into which gamma ray or electron beam enters. When the electrons in substances receive radiation energy, the electrons get high kinetic energy, and the energy and the electric charge shift, at last to the quasi-stable state. This transient state can be experimented with these special accelerators very accurately, during picoseconds, raising the accuracy of the time of incidence of radiation and also raising the accuracy of observation time. The outline of these picosecond, single pulse electron linear accelerators of the University of Tokyo and the Osaka University, including the history, the systems and components and the output beam characteristics, are explained. For example, the maximum energy 30 -- 35 MeV, the peak current 1 -- 8 n C, the pulse width 18 -- 40 ps, the pulse repetition rate 200 -- 720 pps, the energy spectrum 1 -- 1.8% and the output beam diameter 2 -- 5 mm are shown as the output beam characteristics of the accelerators in both universities. The investigations utilizing the picosecond single pulse electron linear accelerators, such as the investigation of short life excitation state by pulsed radiation, the dosimetry study of pulsed radiation, and the investigation of the transforming mechanism and the development of the transforming technology from picosecond, single pulse electron beam to X ray, vacuum ultraviolet ray and visual ray, are described. (Nakai, Y.)

A transmissão psíquica geracional

Directory of Open Access Journals (Sweden)

Vinícius Oliveira dos Santos

Full Text Available O artigo seguinte refere-se a um estudo sobre como ocorre a transmissão psíquica entre as gerações e qual sua importância na constituição psíquica do sujeito. É também objetivo deste artigo explicar o que são as transmissões intergeracional e transgeracional. Para buscar respostas para essas questões, fez-se uma pesquisa bibliográfica sobre a transmissão psíquica, pelo viés psicanalítico, principalmente a partir da teoria lacaniana e com conceitos oriundos da linguística saussuriana. Será a partir de uma determinada ordem simbólica, constituída pela linguagem que precede o sujeito, nomeado por Lacan como o Outro, que a transmissão psíquica entre gerações ganhará o seu caráter unívoco, sempre se tendo em mente a importância fundamental do recalcamento e de seus efeitos, bem como do retorno do recalcado nas diferentes gerações. A transmissão psíquica é necessária e concomitante à constituição do sujeito, e ocorre através da linguagem, dos significantes que irão determinar uma ordem simbólica para o ser que nasce através dos diferentes discursos que perpassam as gerações nas figuras dos pais desse novo ser. Essa ordem simbólica continuará a se fazer presente nesse novo sujeito pelo restante de sua existência. Este artigo busca dar nova luz ao aspecto da transmissão psíquica transgeracional, diferenciando-se da recalque s abordagens psicanalíticas contemporâneas por ser uma leitura lacaniana. Serão usados dois exemplos: um de como a transmissão aparece na cultura, outro, na subjetividade do sujeito através da arte.

The PS Booster, PS and SPS Magnets for the next 25 years

CERN Document Server

Tommasini, D

2010-01-01

This note provides information and analysis on the present status of the magnets installed in the CERN Proton Synchrotron Booster (PSB), the Proton Synchrotron (PS) and the Super Proton Synchrotron (SPS) in view of their possible operation for the next 25 years. The note does not cover the magnets installed in the transfer lines, neither it covers the fast injection/extraction magnets (septa and kickers).

The mechanism of anthracene interaction with photosynthetic apparatus: A study using intact cells, thylakoid membranes and PS II complexes isolated from Chlamydomonas reinhardtii

International Nuclear Information System (INIS)

Aksmann, Anna; Shutova, Tatiana; Samuelsson, Goeran; Tukaj, Zbigniew

2011-01-01

Intact cells of Chlamydomonas reinhardtii as well as isolated thylakoid membranes and photosystem II complexes were used to examine a possible mechanism of anthracene (ANT) interaction with the photosynthetic apparatus. Since ANT concentrations above 1 mM were required to significantly inhibit the rate of oxygen evolution in PS II membrane fragments it may indicate that the toxicant did not directly interact with this photosystem. On the other hand, stimulation of oxygen uptake by ANT-treated thylakoids suggested that ANT could either act as an artificial electron acceptor in the photosynthetic electron transport chain or function as an uncoupler. Electron transfer from excited chlorophyll to ANT is impossible due to the very low reduction potential of ANT and therefore we propose that toxic concentrations of ANT increase the thylakoid membrane permeability and thereby function as an uncoupler, enhancing electron transport in vitro. Hence, its unspecific interference with photosynthetic membranes in vitro suggests that the inhibitory effect observed on intact cell photosynthesis is caused by uncoupling of phosphorylation.

Probability-of-Superiority SEM (PS-SEM—Detecting Probability-Based Multivariate Relationships in Behavioral Research

Directory of Open Access Journals (Sweden)

Johnson Ching-Hong Li

2018-06-01

Full Text Available In behavioral research, exploring bivariate relationships between variables X and Y based on the concept of probability-of-superiority (PS has received increasing attention. Unlike the conventional, linear-based bivariate relationship (e.g., Pearson's correlation, PS defines that X and Y can be related based on their likelihood—e.g., a student who is above mean in SAT has 63% likelihood of achieving an above-mean college GPA. Despite its increasing attention, the concept of PS is restricted to a simple bivariate scenario (X-Y pair, which hinders the development and application of PS in popular multivariate modeling such as structural equation modeling (SEM. Therefore, this study addresses an empirical-based simulation study that explores the potential of detecting PS-based relationship in SEM, called PS-SEM. The simulation results showed that the proposed PS-SEM method can detect and identify PS-based when data follow PS-based relationships, thereby providing a useful method for researchers to explore PS-based SEM in their studies. Conclusions, implications, and future directions based on the findings are also discussed.

Intron-exon organization of the active human protein S gene PS. alpha. and its pseudogene PS. beta. : Duplication and silencing during primate evolution

Energy Technology Data Exchange (ETDEWEB)

Ploos van Amstel, H.; Reitsma, P.H.; van der Logt, C.P.; Bertina, R.M. (University Hospital, Leiden (Netherlands))

1990-08-28

The human protein S locus on chromosome 3 consists of two protein S genes, PS{alpha} and PS{beta}. Here the authors report the cloning and characterization of both genes. Fifteen exons of the PS{alpha} gene were identified that together code for protein S mRNA as derived from the reported protein S cDNAs. Analysis by primer extension of liver protein S mRNA, however, reveals the presence of two mRNA forms that differ in the length of their 5{prime}-noncoding region. Both transcripts contain a 5{prime}-noncoding region longer than found in the protein S cDNAs. The two products may arise from alternative splicing of an additional intron in this region or from the usage of two start sites for transcription. The intron-exon organization of the PS{alpha} gene fully supports the hypothesis that the protein S gene is the product of an evolutional assembling process in which gene modules coding for structural/functional protein units also found in other coagulation proteins have been put upstream of the ancestral gene of a steroid hormone binding protein. The PS{beta} gene is identified as a pseudogene. It contains a large variety of detrimental aberrations, viz., the absence of exon I, a splice site mutation, three stop codons, and a frame shift mutation. Overall the two genes PS{alpha} and PS{beta} show between their exonic sequences 96.5% homology. Southern analysis of primate DNA showed that the duplication of the ancestral protein S gene has occurred after the branching of the orangutan from the African apes. A nonsense mutation that is present in the pseudogene of man also could be identified in one of the two protein S genes of both chimpanzee and gorilla. This implicates that silencing of one of the two protein S genes must have taken place before the divergence of the three African apes.

Experimental study of laser acceleration of planar targets at the wavelength 0.26 μm

International Nuclear Information System (INIS)

Fabbro, R.; Faral, B.; Cottet, F.; Romain, J.P.

1984-01-01

The main characteristics of accelerated aluminum targets, which are the target velocity, the uniformity of the acceleration and the backside temperature have been studied in laser experiments performed at wavelength 0.26 μm with an absorbed flux of a few 10 13 W/cm 2 , in 400-ps pulse duration by using the double-foil technique and an optical pyrometry diagnostic: The ablation pressure was inferred from the velocity measurements. The uniformity of the acceleration was shown to be controlled by the hot spots in the focal spot, and the importance of studying the smoothing of laser inhomogeneities for accelerated targets with large ablated fractions was emphasized. The observed dependence of the backside temperature as a function of the initial foil thickness is discussed in the light of shock wave heating and radiative heating

Evaluation of Recycling Polystyrene (PS) from a Microbiology Product

OpenAIRE

Eklöf, Jonas

2014-01-01

Detta är ett beställningsarbete av Plastone Oy och i det undersöks möjligheterna vad man kan göra genom återvinning med avfallsmaterialet som uppstår då man tillverkar en mikrobiologisk produkt i deras plastfabrik. Produkten tillverkas genom formsprutning och materialet som används är polystyren (PS). Ur litteraturstudien fann man varierande möjligheter på hur man kan återvinna PS på bästa sätt, men ingen lösning som har varit effektiv i praktiken. Det framgick också att återvunnet PS inte är...

A Directory Service for the CERN PS/SL Java Programming Interface

International Nuclear Information System (INIS)

Cuperus, J.; Charrue, P.; DiMaio, F.; Kostro, K.; Watson, W.

1999-01-01

The CERN PS and SL accelerator control groups developed a common application programming interface (API) in Java [1]. Part of this API is a directory service that provide information about the underlying hardware and software. With this information, it is possible to write generic programs that do general actions on lists of devices without hard coding of device names. And, starting from a device name, full details about related devices, the device itself and its class and properties, can be obtained, including the meaning of bits and bit-patterns in status words. The interface definition is independent of any implementation but a reference implementation is provided using Java Database Connectivity (JDBC) against a set of tables in a relational database. Data from very different systems can be brought together and presented in a uniform way to the user. The full potential of the directory service is reached when it is used in software components (Java Beans)

Motor-Generator powering the PS (Proton Synchrotron) main magnets

CERN Multimedia

1983-01-01

This motor-generator,30 MW peak, 1500 r.p.m.,pulsed power supply for the PS main magnet replaced in 1968 the initial 3000 r.p.m. motor-generator-flywheel set which had served from the PS start-up in 1959 until end 1967. See also photo 8302337 and its abstract.

The surface properties of PS/PMMA blends nanostructured polymeric layers

International Nuclear Information System (INIS)

Prosycevas, I.; Tamulevicius, S.; Guobiene, A.

2004-01-01

Solvent cast thin films of blends polystyrene (PS) and poly (methylmethacrylate) (PMMA) with nominal compositions ranging from 25/75 wt.%/v% (w/v) up to 75/25 w/v PS/PMMA with toluene as the mutual solvent on crystalline Si (100) and silica substrates has been studied. Films of PS and PMMA blends have been examined by atomic force microscopy (AFM) and ellipsometry. The blend films with less than 50% PMMA bulk concentration generally exhibit pitted surfaces; the pit size varies with film thickness and bulk composition. When the PMMA bulk concentration is greater than 50%, the film surface can be described as island-like phase-separated structure. The surface segregation and morphology are explained in terms of solubility of the two polymers in the solvent and rewetting of PMMA relative to PS

Effectiveness of early adalimumab therapy in psoriatic arthritis patients from Reuma.pt - EARLY PsA.

Science.gov (United States)

Santos, Helena; Eusébio, Mónica; Borges, Joana; Gonçalves, Diana; Ávila-Ribeiro, Pedro; Faria, Daniela Santos; Lopes, Carina; Rovisco, João; Águeda, Ana; Nero, Patrícia; Valente, Paula; Cravo, Ana Rita; Santos, Maria José

2017-01-01

Objective To compare outcomes in psoriatic arthritis (PsA) patients initiating adalimumab (ADA), with short- and long-term disease duration and to evaluate the potential effect of concomitant conventional synthetic disease-modifying antirheumatic drugs (csDMARD) or glucocorticoids. Methods Analyses included adult PsA patients registered in the Rheumatic Diseases Portuguese Register (Reuma.pt) between June 2008-June 2016 who received ADA for ≥3 months. Psoriatic Arthritis Response Criteria (PsARC) response, tender and swollen joint count, inflammatory parameters, patient (PtGA) and physician global assessment (PhGA), Disease Activity Score-28 joints (DAS28), and Health Assessment Questionnaire Disability Index (HAQ-DI) were compared between patients with PsA) and those with ≥5 years of disease duration (late PsA). Time to achieving PsARC response was estimated using the Kaplan-Meier method. Results Of 135 PsA patients treated with ADA, 126 had information on disease duration (earlyPsA, n=41). PsARC response was achieved by 72.9% of the patients (88.0% early PsA vs 62.2% late PsA; P=0.022) after 3 months and by 85.4% after 24 months (100% early PsA vs 75.9% late PsA; P=0.044). Early PsA patients achieved significantly less painful joints (2.7 vs 6.7, p=0.006), lower mean C-reactive protein (0.5 mg/dL vs 1.3 mg/dL; P=0.011), and PhGA (18.3 vs 28.1; P=0.020) at 3 months. In the long term, early PsA patients also had fewer swollen joints (0.3 vs 1.7; P=0.030) and lower PhGA (6.3 vs 21.9; PPsA, respectively. Early PsA patients obtained PsARC response more rapidly than late PsA (3.8 and 7.4 months, respectively; P=0.008). Concomitant csDMARDs showed clinical benefit (2-year PsARC response, 88.3% vs 60.0%; P=0.044). Concomitant glucocorticoids had no effect on PsARC response over 2 years of follow-up. Persistence on ADA was similar in both groups. Conclusion Early PsA patients had a greater chance of improvement after ADA therapy and better functional outcome, and

Cytochrome b -f complex : The carburettor of exciton distribution in ...

Indian Academy of Sciences (India)

tribpo

of gaps which need to be explored. 2. Molecular ... A decrease in the yield of chlorophyll fluorescence of PS II was caused by the addition of ATP ... Similarly, in maize mutant (hcf 6) which lacks cyt b6-f complex but possesses PS. II, LHC II and ...

CoPs Facing Rationalization: The Politics of Community Reproduction

Science.gov (United States)

Kilskar, Stine Skaufel; Ingvaldsen, Jonas A.; Valle, Nina

2018-01-01

Purpose: This paper aims to explore the relationship between the contemporary forms of manufacturing rationalization and the reproduction of communities of practice (CoPs) centred on tasks and craft. Building on critical literature highlighting the tensions between CoPs and rationalization, this paper aims to develop a nuanced account of how CoPs…

Antiphosphatidylserine/prothrombin antibodies (aPS/PT) as potential markers of antiphospholipid syndrome.

Science.gov (United States)

Vlagea, Alexandru; Gil, Antonio; Cuesta, Maria V; Arribas, Florencia; Diez, Jesús; Lavilla, Paz; Pascual-Salcedo, Dora

2013-06-01

The antiphospholipid antibodies present in antiphospholipid syndrome (APS) are directed at a number of phospholipid-binding proteins: β2 glycoprotein I (β2GPI), prothrombin, and so on. Antibodies directed at β2GPI are accepted as a classification criterion for APS, while the presence of antiprothrombin antibodies is not. In the present article, we investigated the possible role of antiphosphatidylserine/prothrombin antibodies (aPS/PT) as marker of APS on a cohort of 295 individuals with APS (95 primary APS and 45 secondary APS) and APS-related diseases. We found aPS/PT to be highly associated with venous thrombosis (immunoglobulin G [IgG] aPS/PT odds ratio [OR], 7.44; 95% confidence interval [CI], 3.97-13.92 and IgM aPS/PT OR, 2.54; 95% CI, 1.35-4.77) and obstetric abnormalities (IgG aPS/PT OR, 2.37; 95% CI, 1.04-5.43), but not with arterial thrombosis. A very high degree of concordance between the concentration of aPS/PT and lupus anticoagulant activity was demonstrated. Therefore, we support the inclusion of aPS/PT determination as second-level assay to confirm APS classification.

From nGy to MGy - new TL dosimetry of complex radiation at high-energy accelerators and thermonuclear fusion facilities

International Nuclear Information System (INIS)

Obryk, B.; Bilski, P.; Budzanowski, M.; Olko, P.

2011-01-01

One of the well known advantages of thermoluminescence (TL) detectors made of lithium fluoride doped with magnesium, copper and phosphorus (LiF:Mg,Cu,P) is their very high sensitivity to ionizing radiation. LiF:Mg,Cu,P detectors enable measurements of radiation doses from tens of nano grays up to a few kilo grays, when the total saturation of the signal of the so-called main dosimetric peak (at about 220 C. degrees) occurs. In 2006 for the first time we observed unprecedented high-temperature emission of LiF detectors heated to temperatures up to 600 C. degrees, after exposures to radiation doses ranging from 1 kGy to 1 MGy. For quantification of the glow curve shape changes of LiF:Mg,Cu,P detectors in this range of doses and determination of the absorbed dose, the high temperature coefficient (UHTR) was defined. This newly established dosimetric method was tested in a range of radiation qualities, such as gamma radiation, electron and proton beams, thermal neutron fields and in high-energy mixed fields around the SPS and PS accelerators at CERN. A number of dosimetric sets with LiF:Mg,Cu,P detectors are currently installed around the LHC at CERN. The new method for ultra-high dose range monitoring with a single LiF:Mg,Cu,P detector, which is capable of covering at least twelve orders of magnitude of doses, can be used for dosimetry at high energy accelerators and has great potential for accident dosimetry in particular. (authors)

Spectrum Analyzer Application for the Proton Synchrotron Wall Current Monitors

CERN Document Server

Limpens, Rik

The Proton Synchrotron (PS) is a key component in CERN's accelerator complex, where it usually accelerates either protons or heavy ions. The new acquisition system for the PS ring wall current monitors has been installed to be able to perform higher frequency measurements of a beam bunch. This is an important improvement, since the oscillating signals are related to losses of a beam bunch. The main goal of this project is to develop a LabVIEW application running on a Real-Time target to perform continuous and triggered spectral acquisition of a PS beam bunch and to provide a data visualization and analysis tool for the operators and users of the machine.

Beyond the Point Ps Approximation

OpenAIRE

Stepanov, Sergey V.; Zvezhinskiy, Dmitry S.; Byakov, Vsevolod M.

2012-01-01

In application to positron annihilation spectroscopy, Ps atom is considered not as a point particle, but as a finite size e+ e- pair localized in a bubble-state in a medium. Variation of the internal Coulombic e+ -e- attraction vs. the bubble radius is estimated.

Complex formation in aqueous trimethylamine-N-oxide (TMAO) solutions.

Science.gov (United States)

Hunger, Johannes; Tielrooij, Klaas-Jan; Buchner, Richard; Bonn, Mischa; Bakker, Huib J

2012-04-26

We study aqueous solutions of the amphiphilic osmolyte trimethylamine-N-oxide (TMAO) using broadband dielectric spectroscopy and femtosecond mid-infrared spectroscopy. Both experiments provide strong evidence for distinctively slower rotation dynamics for water molecules interacting with the hydrophobic part of the TMAO molecules. Further, water is found to interact more strongly at the hydrophilic site of the TMAO molecules: we find evidence for the formation of stable, TMAO·2H2O and/or TMAO·3H2O complexes. While this coordination structure seems obvious, the lifetime of these complexes is found to be extraordinarily long (>50 ps). The existence of these long-lived complexes leads to pronounced parallel dipole correlations between water and TMAO, reflected in enhanced amplitudes in the dielectric spectra. The strong interaction between water and TMAO also results in a red-shifted band for the O-D stretching vibration of HDO molecules in an isotopically diluted aqueous TMAO solution. This O-D stretching vibration has a vibrational lifetime of 670 fs, which is significantly shorter than the lifetime of the O-D stretch vibration of bulk-like HDO molecules, presumably due to efficient coupling to vibrational modes of TMAO. The rotational dynamics of these O-D groups are slowed down dramatically, and are limited by the rotation of the whole complex, while the O-D vector oriented away from TMAO probably shows an accelerated reorientation.

RF Scenarios for Pb54+ Ions in the PS2

CERN Document Server

Benedikt, M; Hancock, S; CERN. Geneva. AB Department

2008-01-01

This note analyses some of the rf scenarios that are presently being considered for lead ions in the PS2. An earlier note principally concerning protons [1] highlighted the problem of the large revolution frequency swing of ions in the PS2 and the issue of bunching factor with direct injection from the LEIR machine. We present solutions based on additional rf systems in LEIR and consider the 40 MHz principal rf system proposed for the PS2 in the earlier work to have switchable tuning ranges to cover the large frequency swing required.

Role of trapped and solvated electrons in Ps formation

International Nuclear Information System (INIS)

Stepanov, S.V.; Byakov, V.M.; Mikhin, K.V.; He, C.; Hirade, T.

2005-01-01

Role of trapped and solvated electrons in Ps formation is discussed. Combination of thermalized positron with such electrons is possible from the view point of the energy balance and may results in Ps formation. This process proceeds during all e = lifetime matter. Fitting of raw experimental e + -e - annihilation spectra has to be based on an adequate physical input, which often leads to necessity of nonexponential deconvolution of the spectra. We have interpreted the Ps formation data in polyethylene, ethylene-methylmethacrylate and polymethylmethacrylate in dark and in light vs. tome of the measurement and temperature. parameters characterized accumulation of trapped electrons and their recombination with counter ions and positrons are obtained. (author)

High intensity proton operation at the Brookhaven AGS accelerator complex

International Nuclear Information System (INIS)

Ahrens, L.A.; Blaskiewicz, M.; Bleser, E.; Brennan, J.M.; Gardner, C.; Glenn, J.W.; Onillon, E.; Reece, R.K.; Roser, T.; Soukas, A.

1994-01-01

With the completion of the AGS rf upgrade, and the implementation of a transition open-quotes jumpclose quotes, all of accelerator systems were in place in 1994 to allow acceleration of the proton intensity available from the AGS Booster injector to AGS extraction energy and delivery to the high energy users. Beam commissioning results with these new systems are presented. Progress in identifying and overcoming other obstacles to higher intensity are given. These include a careful exploration of the stopband strengths present on the AGS injection magnetic porch, and implementation of the AGS single bunch transverse dampers throughout the acceleration cycle

A New High-intensity Proton Irradiation Facility at the CERN PS East Area

CERN Document Server

Gkotse, B; Lima, P; Matli, E; Moll, M; Ravotti, F

2014-01-01

and IRRAD2), were heavily and successfully used for irradiation of particle detectors, electronic components and materials since 1992. These facilities operated with particle bursts - protons with momentum of 24GeV/c - delivered from the PS accelerator in “spills” of about 400ms (slow extraction). With the increasing demand of irradiation experiments, these facilities suffered from a number of restrictions such as the space availability, the maximum achievable particle flux and several access constraints. In the framework of the AIDA project, an upgrade of these facilities has been realized during the CERN long shutdown (LS1). While the new proton facility (IRRAD) will continue to be mainly devoted to the radiation hardness studies for the High Energy Physics (HEP) experimental community, the new mixed-field facility (CHARM) will mainly host irradiation experiments for the validation of electronic systems used in a...

Anti-prothrombin (aPT) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies and the risk of thrombosis in the antiphospholipid syndrome. A systematic review.

Science.gov (United States)

Sciascia, Savino; Sanna, Giovanni; Murru, Veronica; Roccatello, Dario; Khamashta, Munther A; Bertolaccini, Maria Laura

2014-02-01

Antibodies to prothrombin are detected by directly coating prothrombin on irradiated ELISA plates (aPT) or by using the phosphatidylserine/prothrombin complex as antigen (aPS/PT). Although these antibodies have both been associated with antiphospholipid syndrome (APS) and a correlation between the two assays have been reported, it seems that aPT and aPS/PT belong to different populations of autoantibodies. It was our objective to systematically review the available evidence on aPT and aPS/PT antibodies and the risk of thrombosis in APS. Medline-reports published between 1988 and 2013 investigating aPT and aPS/PT as a risk factor for thrombosis were included. Whenever possible, antibody isotype(s) and site of thrombosis were analysed. This systematic review is based on available data from more than 7,000 patients and controls from 38 studies analysing aPT and 10 aPS/PT. Antibodies to prothrombin (both aPT and aPS/PT) increased the risk of thrombosis (odds ratio [OR] 2.3; 95% confidence interval [CI] 1.72-3.5). aPS/PT seemed to represent a stronger risk factor for thrombosis, both arterial and/or venous than aPT (OR 5.11; 95%CI 4.2-6.3 and OR 1.82; 95%CI 1.44-2.75, respectively). In conclusion, routine measurement of aPS/PT (but not aPT) might be useful in establishing the thrombotic risk of patients with previous thrombosis and/or systemic lupus erythematosus. Their inclusion as laboratory criteria for the APS should be indisputably further explored.

Discovery Mondays "Controlling the accelerators: tracking the protons"

CERN Multimedia

2007-01-01

Le Centre de contrôle des accélérateurs du CERN.Like a train of particles that picks up speed every time it passes a set of points, by the time they collide the protons and ions in the LHC will have followed their path through the six stages of the CERN accelerator complex, picking up speed at each stage. Operating the controls of this huge complex designed to accelerate the infinitesimally small are its peerless controllers. From the CERN Control Centre, they will be on duty day and night to accelerate the "wagon-loads" of particles, ensuring that they stay on track and lining them up for head-on collisions. At the next Discovery Monday you will discover the path taken by the particles through the accelerator chain. You will gain an insight into the complex work performed by those controlling the particles and learn more about the CERN accelerator complex and its Control Centre. Hop on board for a speed-of-light tour of the C...

A 96-channel, 500 ps resolution TDC board for the BaBar experiment at SLAC

CERN Document Server

Minutoli, S

2000-01-01

A TDC board has been designed and built to complete the readout of the Instrumented Flux Return of the BABAR experiment at the Stanford Linear Accelerator Center. The board has 96 input channels and makes use of 3 general purpose TDC chips designed at CERN, with time resolution up to 500 ps and configurable via a Test Access Port (IEEE standard 1149). Data are stored before readout in a multievent buffer. Communication with BABAR DAQ system is realized through 3 serial lines on the backplane connector. All the logic, including internal registers and the interfaces with the BABAR protocol and the TAP controller, is implemented in two fast FPGAs. The board is designed to work at 59.5 MHz clock frequency. (7 refs).

Clinical and Patient-reported Outcomes in Patients with Psoriatic Arthritis (PsA) by Body Surface Area Affected by Psoriasis: Results from the Corrona PsA/Spondyloarthritis Registry.

Science.gov (United States)

Mease, Philip J; Karki, Chitra; Palmer, Jacqueline B; Etzel, Carol J; Kavanaugh, Arthur; Ritchlin, Christopher T; Malley, Wendi; Herrera, Vivian; Tran, Melody; Greenberg, Jeffrey D

2017-08-01

Psoriatic arthritis (PsA) is commonly comorbid with psoriasis; the extent of skin lesions is a major contributor to psoriatic disease severity/burden. We evaluated whether extent of skin involvement with psoriasis [body surface area (BSA) > 3% vs ≤ 3%] affects overall clinical and patient-reported outcomes (PRO) in patients with PsA. Using the Corrona PsA/Spondyloarthritis Registry, patient characteristics, disease activity, and PRO at registry enrollment were assessed for patients with PsA aged ≥ 18 years with BSA > 3% versus ≤ 3%. Regression models were used to evaluate associations of BSA level with outcome [modified minimal disease activity (MDA), Health Assessment Questionnaire (HAQ) score, patient-reported pain and fatigue, and the Work Productivity and Activity Impairment questionnaire score]. Adjustments were made for age, sex, race, body mass index, disease duration, and history of biologics, disease-modifying antirheumatic drug, and prednisone use. This analysis included 1240 patients with PsA with known BSA level (n = 451, BSA > 3%; n = 789, BSA ≤ 3%). After adjusting for potential confounding variables, patients with BSA > 3% versus ≤ 3% had greater patient-reported pain and fatigue and higher HAQ scores (p = 2.33 × 10 -8 , p = 0.002, and p = 1.21 × 10 -7 , respectively), were 1.7× more likely not to be in modified MDA (95% CI 1.21-2.41, p = 0.002), and were 2.1× more likely to have overall work impairment (1.37-3.21, p = 0.0001). These Corrona Registry data show that substantial skin involvement (BSA > 3%) is associated with greater PsA disease burden, underscoring the importance of assessing and effectively managing psoriasis in patients with PsA because this may be a contributing factor in PsA severity.

Positronium Inhibition and Quenching by Organic Electron Acceptors and Charge Transfer Complexes

DEFF Research Database (Denmark)

Jansen, P.; Eldrup, Morten Mostgaard; Jensen, Bror Skytte

1975-01-01

Positron lifetime measurements were performed on a series of organic electron acceptors and charge-transfer complexes in solution. The acceptors cause both positronium (Ps) inhibition (with maybe one exception) and quenching, but when an acceptor takes part in a charge-transfer complex...... in terms of the spur reaction model of Ps formation. Correlation was also made to gas phase reaction between electron acceptors and free electron, as well as to pulse radiolysis data....

Jagiellonian University Advances in Ps Manipulations and Laser Studies in the AEgIS Experiment

CERN Document Server

Caravita, R; Amsler, C; Bonomi, G; Brusa, R S; Caccia, M; Castelli, F; Cerchiari, G; Comparat, D; Consolati, G; Demetrio, A; Di Noto, L; Doser, M; Evans, C; Ferragut, R; Fesel, J; Fontana, A; Gerber, S; Giammarchi, M; Gligorova, A; Guatieri, F; Haider, S; Hinterberger, A; Holmestad, H; Kellerbauer, A; Khalidova, O; Krasnický, D; Lagomarsino, V; Lansonneur, P; Lebrun, P; Malbrunot, C; Mariazzi, S; Marton, J; Matveev, V; Mazzotta, Z; Müller, S R; Nebbia, G; Nedelec, P; Oberthaler, M; Pacifico, N; Pagano, D; Penasa, L; Petracek, V; Prelz, F; Prevedelli, M; Ravelli, L; Rienäcker, B; Robert, J; Røhne, O M; Rotondi, A; Sandaker, H; Santoro, R; Smestad, L; Sorrentino, F; Testera, G; Tietje, I; Widmann, E; Yzombard, P; Zimmer, C; Zmeskal, J; Zurlo, N

2017-01-01

Positronium (Ps), the unstable bound state of electron and positron, is a valuable system for neutral antimatter spectroscopic studies and for antihydrogen production. Forming a pulsed beam cold antihydrogen using charge-exchange with the Rydberg Ps is the goal of the AEgIS Collaboration, which aims to measure gravity on neutral antimatter. Recent results achieved in producing, manipulating and studying Ps are summarized. Ps has been first produced with mesoporous silica targets in a reflection geometry. Spectroscopy of Ps n = 3 state has been conducted, yielding as a byproduct an independent estimate of the produced Ps temperature. Efficient laser excitation to the Rydberg levels was then achieved, validating the proof-of-concept of AEgIS. Subsequently, production of Ps from a new class of transmission targets was also achieved, opening the possibility for future experiments.

Experimental study of laser acceleration of planar targets at the wavelength 0. 26. mu. m

Energy Technology Data Exchange (ETDEWEB)

Fabbro, R.; Faral, B.; Cottet, F.; Romain, J.P.

1984-12-01

The main characteristics of accelerated aluminum targets, which are the target velocity, the uniformity of the acceleration and the backside temperature have been studied in laser experiments performed at wavelength 0.26 ..mu..m with an absorbed flux of a few 10/sup 13/ W/cm/sup 2/, in 400-ps pulse duration by using the double-foil technique and an optical pyrometry diagnostic: The ablation pressure was inferred from the velocity measurements. The uniformity of the acceleration was shown to be controlled by the hot spots in the focal spot, and the importance of studying the smoothing of laser inhomogeneities for accelerated targets with large ablated fractions was emphasized. The observed dependence of the backside temperature as a function of the initial foil thickness is discussed in the light of shock wave heating and radiative heating.

The Brookhaven Accelerator Test Facility

International Nuclear Information System (INIS)

Batchelor, K.; Chou, T.S.; Fernow, R.C.

1988-01-01

The Brookhaven Accelerator Test Facility (ATF) will consist of a 50--100 MeV/c electron linac and a 100 GW CO 2 laser system. A high brightness RF-gun operating at 2856 MHz is to be used as the injector into the linac. The RF-gun contains a Nd:Yag-laser-driven photocathode capable of producing a stream of six ps electron pulses separated by 12.5 ns. The maximum charge in a micropulse will be one nano-Coulomb. The CO 2 laser pulse length will be a few picoseconds and will be synchronized with the electron pulse. The first experimental beam is expected in Fall 89. The design electron beam parameters are given and possible initial experiments are discussed. 9 refs., 1 fig., 3 tabs

TiPs: a database of therapeutic targets in pathogens and associated tools.

KAUST Repository

Lepore, Rosalba

2013-05-21

MOTIVATION: The need for new drugs and new targets is particularly compelling in an era that is witnessing an alarming increase of drug resistance in human pathogens. The identification of new targets of known drugs is a promising approach, which has proven successful in several cases. Here, we describe a database that includes information on 5153 putative drug-target pairs for 150 human pathogens derived from available drug-target crystallographic complexes. AVAILABILITY AND IMPLEMENTATION: The TiPs database is freely available at http://biocomputing.it/tips. CONTACT: anna.tramontano@uniroma1.it or allegra.via@uniroma1.it.

DiPS: A Unifying Approach for developing System Software

OpenAIRE

Michiels, Sam; Matthijs, Frank; Walravens, Dirk; Verbaeten, Pierre

2002-01-01

In this paper we unify three essential features for flexible system software: a component oriented approach, self-adaptation and separation of concerns.We propose DiPS (Distrinet Protocol Stack), a component framework, which offers components, an anonymous interaction model and connectors to handle non-functional aspects such as concurrency. DiPS has effectively been used in industrial protocol stacks and device drivers.

Modelling of Ne-like copper X-ray laser driven by 1.2 ps short pulse and 280 ps background pulse configuration

International Nuclear Information System (INIS)

Demir, A.; Kenar, N.; Goktas, H.; Tallents, G.J.

2004-01-01

Detailed simulations of Ne-like Cu x-ray laser are undertaken using the EHYBRID code. The atomic physics data are obtained using the Cowan code. The optimization calculations are performed in terms of the intensity of background and the time separation between the background and the short pulse. The optimum value is obtained for the conditions of a Nd:glass laser with 1.2 ps pulse at 4.4 x 10 15 W cm -2 irradiance pumping a plasma pre-formed by a 280 ps duration pulse at 5.4 x 10 12 W cm -2 with peak-to-peak pulse separation set at 300 ps. X-ray resonance lines between 6 A and 15 A emitted from copper plasmas have been simulated. Free-free and free-bound emission from the Si-, Al-, Mg-, Na-, Ne- and F-like ions is calculated in the simulation. (author)

Framing-camera tube developed for sub-100-ps range

International Nuclear Information System (INIS)

Anon.

1978-01-01

A new framing-camera tube, developed by Electronics Engineering, is capable of recording two-dimensional image frames with high spatial resolution in the sub-100-ps range. Framing is performed by streaking a two-dimensional electron image across narrow slits; the resulting electron-line images from the slits are restored into a framed image by a restorer deflector operating synchronously with the dissector deflector. We have demonstrated its performance in a prototype tube by recording 125-ps-duration framed images of 2.5-mm patterns. The limitation in the framing speed is in the external electronic drivers for the deflectors and not in the tube design characteristics. Shorter frame durations (below 100 ps) can be obtained by use of faster deflection drivers

Electrophysical properties of PMN-PT-PS-PFN:Li ceramics

Directory of Open Access Journals (Sweden)

R. Skulski

2013-01-01

Full Text Available We present the technology of obtaining and the electrophysical properties of a multicomponent material 0.61PMN-0.20PT-0.09PS-0.1PFN:Li (PMN-PT-PS-PFN:Li. The addition of PFN into PMN-PT decreases the temperature of final sintering which is very important during technological process (addition of Li decreases electric conductivity of PFN. Addition of PS i.e., PbSnO3 (which is unstable in ceramic form permits to shift the temperature of the maximum of dielectric permittivity. One-step method of obtaining ceramic samples from oxides and carbonates has been used. XRD, microstructure, scanning calorimetry measurements and the main dielectric, ferroelectric and electromechanical properties have been investigated for the obtained samples.

The four Ps of marketing mix in Information Science literature

OpenAIRE

Amaral, Sueli Angelica Do

2000-01-01

Analisa 60 documentos sobre os 4Ps do composto de marketing cm unidades de informação da literatura de Ciência da Informação no período de 1975 a 1995, para conhecer quantos e quais autores escreveram sobre o tema, qual o pioneiro, quem foi o pioneiro a propor adição de Ps. Apresenta a cronologia dos documentos estudados e discute as 4Ps do composto de marketing. Propõe a adoção da mais completa proposta analisada como forma de garantir o futuro das unidades de informação. ___________________...

Heavy ion accelerators for inertial fusion

International Nuclear Information System (INIS)

Rubbia, C.

1992-01-01

Particle accelerators are used for accelerating the elementary, stable and separable constituents of matters to relativistic speed. These beams are of fundamental interest in the study on the ultimate constituents of matters and their interaction. Particle accelerators are the most promising driver for the fusion power reactors based on inertial confinement. The principle of inertial confinement fusion, radiation driven indirect drive, the accelerator complex and so on are described. (K.I.)

The TDCpix readout ASIC: A 75 ps resolution timing front-end for the NA62 Gigatracker hybrid pixel detector

Energy Technology Data Exchange (ETDEWEB)

Kluge, A., E-mail: alexander.kluge@cern.ch; Aglieri Rinella, G.; Bonacini, S.; Jarron, P.; Kaplon, J.; Morel, M.; Noy, M.; Perktold, L.; Poltorak, K.

2013-12-21

The TDCpix is a novel pixel readout ASIC for the NA62 Gigatracker detector. NA62 is a new experiment being installed at the CERN Super Proton Synchrotron. Its Gigatracker detector shall provide on-beam tracking and time stamping of individual particles with a time resolution of 150 ps rms. It will consist of three tracking stations, each with one hybrid pixel sensor. The peak flow of particles crossing the detector modules reaches 1.27 MHz/mm{sup 2} for a total rate of about 0.75 GHz. Ten TDCpix chips will be bump-bonded to every silicon pixel sensor. Each chip shall perform time stamping of 100 M particle hits per second with a detection efficiency above 99% and a timing accuracy better than 200 ps rms for an overall three-station-setup time resolution of better than 150 ps. The TDCpix chip has been designed in a 130 nm CMOS technology. It will feature 45×40 square pixels of 300×300μm{sup 2} and a complex End of Column peripheral region including an array of TDCs based on DLLs, four high speed serializers, a low-jitter PLL, readout and control circuits. This contribution will describe the complete design of the final TDCpix ASIC. It will discuss design choices, the challenges faced and some of the lessons learned. Furthermore, experimental results from the testing of circuit prototypes will be presented. These demonstrate the achievement of key performance figures such as a time resolution of the processing chain of 75 ps rms with a laser sent to the center of the pixel and the capability of time stamping charged particles with an overall resolution below 200 ps rms. -- Highlights: • Feasibility demonstration of a silicon pixel detector with sub-ns time tagging capability. • Demonstrator detector assembly with a time resolution of 75 ps RMS with laser charge injection; 170 ps RMS with particle beam. • Design of trigger-less TDCpix ASIC with 1800 pixels, 720 TDC channels and 4 3.2 Gbit/s serializers.

JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes.

Science.gov (United States)

Yin, T; Tsang, M L; Yang, Y C

1994-10-28

Interleukin (IL)-4 and IL-9 regulate the proliferation of T lymphocytes through interactions with their receptors. Previous studies have shown that unknown tyrosine kinases are involved in the proliferative signaling triggered by IL-4 and IL-9. Here we show that IL-4 and IL-9 induce overlapping (170, 130, and 125 kilodalton (kDa)) and distinct (45 and 88/90 kDa, respectively) protein tyrosine phosphorylation in T lymphocytes. We further identify the 170-kDa tyrosine-phosphorylated protein as 4PS/insulin receptor substrate-1-like (IRS-1L) protein and 130-kDa protein as JAK1 kinase. Furthermore, we demonstrate for the first time that JAK1 forms complexes with the IL-4 receptor and 4PS/IRS-1L protein following ligand-receptor interaction. In addition, we demonstrate that IL-9, but not IL-4, induced tyrosine phosphorylation of Stat 91 transcriptional factor. The overlapping and distinct protein tyrosine phosphorylation and activation of the same JAK1 kinase in T lymphocytes strongly suggests that IL-4 and IL-9 share the common signal transduction pathways and that the specificity for each cytokine could be achieved through the unique tyrosine-phosphorylated proteins triggered by individual cytokines.

HiPS - Hierarchical Progressive Survey Version 1.0

Science.gov (United States)

Fernique, Pierre; Allen, Mark; Boch, Thomas; Donaldson, Tom; Durand, Daniel; Ebisawa, Ken; Michel, Laurent; Salgado, Jesus; Stoehr, Felix; Fernique, Pierre

2017-05-01

This document presents HiPS, a hierarchical scheme for the description, storage and access of sky survey data. The system is based on hierarchical tiling of sky regions at finer and finer spatial resolution which facilitates a progressive view of a survey, and supports multi-resolution zooming and panning. HiPS uses the HEALPix tessellation of the sky as the basis for the scheme and is implemented as a simple file structure with a direct indexing scheme that leads to practical implementations.

Physics with primary beams of the KEK-PS

International Nuclear Information System (INIS)

Tanaka, Kazuhiro; Yoshii, Masahito

1993-08-01

The 12-GeV Proton Synchrotron (PS) at the National Laboratory for High Energy Physics (KEK) has provided great opportunities to high-energy-physics and related communities as a unique high-energy hadron machine, since its operation in 1976. Activities of the KEK-PS are indispensable for the rapid development in the field. Six experimental subjects are proposed in this Report; (1) media effects in φ meson decay, (2) multifragmentation in high-energy reactions, (3) mechanism of high-energy reactions by means of radio-chemical methods, (4) physics with polarized high-energy neutrons, (5) physics with polarized high-energy deuterons, and (6) hypernucleus with high-energy heavy-ion beams. As a summary, new facilities (a new injector, a new beamline and a new experimental area) and physics programs with primary beams, proposed in this Report are themselves unique and valuable. Moreover, technical developments and physics outcomes stimulated with those new facilities are indispensable for future plans of the KEK-PS. (J.P.N.)

Cyclotron method for heavy ion acceleration

International Nuclear Information System (INIS)

Gikal, B.N.; Gul'bekyan, G.G.; Kutner, V.B.; Oganesyan, R.Ts.

1984-01-01

Studies on heavy ion beams in a wide range of masses (up to uranium) and energies disclose essential potential opportunities for solution of both fundamental scientific and significant economical problems. A cyclotron method for heavy ion acceleration is considered. Development of low and medium energy heavy ion accelerators is revealed. The design of a complex comprising two isochronous cyclotrons which is planned to be constrdcted 1n the JINR is described. The cyclotron complex includes the U-400 and the U-400 M cyclotrons and it is intended for acceleration of both 35-20 MeV/nucleon superheavy ions such as Xe-U and 120 MeV/nucleon light ions. Certain systems of the accelerators are described. Prospects of the U-400 and the U-400 M development are displayed

Syntheses of polystyrene supported chelating resin containing the Schiff base derived from salicylaldehyde and triethylene tetramine and its copper(II), nickel(II), cobalt(II), iron(III), zinc(II), cadmium(II), molybdenum(VI), zirconium(IV) and uranium(VI) complexes

International Nuclear Information System (INIS)

Syamal, A.; Singh, M.M.

1998-01-01

A new polymer-anchored chelating ligand has been synthesized by the reaction of chloromethylated polystyrene (containing 0.94 mmol of Cl per gram of resin and 1% cross-linked with divinylbenzene) and the Schiff base derived from salicylaldehyde and triethylenetetramine. A new series of polystyrene supported, Cu(II), Ni(II), Co(II), Fe(III), Zn(II), Cd(II), Zr(IV), dioxomolybdenum (VI) and dioxouranium (VI) complexes of the formulae PS-LCu, PS-LNi, PS-LCo, PS-LFeCl.DMF, PS-LZn, PS-LCd, PS-LZr(OH) 2 . DMF, PS L MoO 2 and PS-LUO 2 (where PS-LH 2 = polymer-anchored Schiff base and DMF dimethyl-formamide) have been synthesized and characterised by elemental analysis, infrared, electronic spectra and magnetic susceptibility measurements. The complexes PS-LCu, PS-LNi and PS-LCo have square planar structure, PS-LFeCl.DMF, PS-LMoO 2 and PS-LUO 2 have octahedral structure, PS L Zn and PS-LCd are tetrahedral and PS-LZr(OH) 2 .DMF is pentagonal bipyramidal. The polymer-anchored Cu(II), Co(II) and Fe(III) complexes are paramagnetic while Ni(II), Zn(II), Cd(II), Zr(IV), dioxomolybdenum(VI) and dioxouranium(VI) complexes are diamagnetic. The negative shift of the v (C=N) (azomethine) and the positive shift of v (C--O)(phenolic) are indicative of ONNO donor behaviour of the polymer-anchored Schiff base. (author)

Replacing PS controls front end minicomputers by VME based 32-bit processors

International Nuclear Information System (INIS)

Gagnaire, A.; Metz Noblat, N. de; Serre, Ch.; Sicard, Cl.H.

1992-01-01

The PS controls have started the first phase of system rejuvenation, targeted towards the LEP Preinjector Controls. The main impact of this phase is in the architectural change, as both the front-end minicomputers and the CAMAC embedded microprocessors are replaced by microprocessor based VME crates called Device Stub Controllers (DSC). This paper discusses the different steps planned for this first phase, i.e: (1) implementing the basic set of CERN Accelerator common facilities for DSCs (error handling, system surveillance, remote boot and network access); (2) porting the equipment access software layer; (3) applying the Real-time tasks to the LynxOS operating system and I/O architecture, conforming to the real-time constraints for control and acquisition; (4) defining the number and contents of the different DSC needed, according to geographical and cpu-load constraints; (5) providing the general services outside the DSC crates (file servers, data-base services); (6) emulating the current Console programs onto the new workstations. (author)

Improvement of the 400 kV linac electron source of AmPS

International Nuclear Information System (INIS)

Kroes, F.B.; Beuzekom, M.G. van; Dobbe, N.J.; Es, J.T. van; Jansweijer, P.P.M.; Kruijer, A.H.; Luigjes, G.; Sluijk, T.G.B.

1992-01-01

An existing linac (MEA) injects electrons into the Amsterdam Pulse Stretcher (AmPS) ring. The linac's peak current increases from 20 to 80 mA. This requires the modification of the 400 kV low emittance gun. The fourfold increase of the peak current is obtained by doubling both the gun perveance (new gun part) and the pulsed extractor voltage. To obtain optimum beam quality over this increased current range, the hot deck electronics has been exchanged by a fast high voltage FET switching supply. A built-in microprocessor, coupled to the local computer by optical fibers, is used to monitor and control the gun parameters. The 5 kV gun extractor voltage pulse shape can be monitored by means of an analog fibre transducer with build in calibration. Finally, in order to improve the energy stability of the accelerated electrons, a serial electron-tube stabilizer was added to the 400 kV DC power supply. (K.A.) 4 refs.; 6 figs

Kultuur isiksuse psühholoogiat ei mõjuta / Tiit Kändler

Index Scriptorium Estoniae

Kändler, Tiit, 1948-

2010-01-01

Psühholoogia uuemate andmete kohaselt ei sõltu indiviidi seadumus kultuurist, soost, vanusest, haridusest. Eesti psühholoogide Jüri Alliku ja Ann Realo osalusel ajakirjas "Journal Personality and Social Psychology" ilmunud artiklist

Kultuur isiksuse psühholoogiat ei mõjuta / Tiit Kändler

Index Scriptorium Estoniae

Kändler, Tiit, 1948-

2005-01-01

Psühholoogia uuemate andmete kohaselt ei sõltu indiviidi seadumus kultuurist, soost, vanusest, haridusest. Eesti psühholoogide Jüri Alliku ja Anu Realo osalusel ajakirjas "Journal Personality and Social Psychology" ilmunud artiklist

File list: His.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.PSC.10.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX110016,S...315,SRX381309 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.10.AllAg.iPS_cells.bed ...

File list: His.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.PSC.05.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX317576,S...077,SRX317607 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.05.AllAg.iPS_cells.bed ...

File list: Oth.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Oth.PSC.05.AllAg.iPS_cells mm9 TFs and others Pluripotent stem cell iPS cells SRX65...RX146524 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.AllAg.iPS_cells.bed ...

File list: His.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.PSC.20.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX110015,S...315,SRX381309 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.20.AllAg.iPS_cells.bed ...

Comparison of molecular species of various transphosphatidylated phosphatidylserine (PS) with bovine cortex PS by mass spectrometry

NARCIS (Netherlands)

Chen, S.; Li, K.W.

2008-01-01

The exogenous introduction of a molecular species mixture of bovine cortex phosphatidylserine (BC-PS) has been claimed to improve memory function in subjects suffering from age-associated memory impairment and dementia. However, it has been also reported that oral administration of another molecular

Peer support of complex health behaviors in prevention and disease management with special reference to diabetes: systematic reviews.

Science.gov (United States)

Fisher, Edwin B; Boothroyd, Renée I; Elstad, Emily A; Hays, Laura; Henes, Amy; Maslow, Gary R; Velicer, Clayton

2017-01-01

Examine Peer Support (PS) for complex, sustained health behaviors in prevention or disease management with emphasis on diabetes prevention and management. PS was defined as emotional, motivational and practical assistance provided by nonprofessionals for complex health behaviors. Initial review examined 65 studies drawn from 1442 abstracts identified through PubMed, published 1/1/2000-7/15/2011. From this search, 24 reviews were also identified. Extension of the search in diabetes identified 30 studies published 1/1/2000-12/31/2015. In initial review, 54 of all 65 studies (83.1%) reported significant impacts of PS, 40 (61.5%) reporting between-group differences and another 14 (21.5%) reporting significant within-group changes. Across 19 of 24 reviews providing quantifiable findings, a median of 64.5% of studies reviewed reported significant effects of PS. In extended review of diabetes, 26 of all 30 studies (86.7%) reported significant impacts of PS, 17 (56.7%) reporting between-group differences and another nine (30.0%) reporting significant within-group changes. Among 19 of these 30 reporting HbA1c data, average reduction was 0.76 points. Studies that did not find effects of PS included other sources of support, implementation or methodological problems, lack of acceptance of interventions, poor fit to recipient needs, and possible harm of unmoderated PS. Across diverse settings, including under-resourced countries and health care systems, PS is effective in improving complex health behaviors in disease prevention and management including in diabetes.

Future directions in controlling the LAMPF-PSR accelerator complex at Los Alamos National Laboratory

International Nuclear Information System (INIS)

Stuewe, R.; Schaller, S.; Bjorklund, E.

1992-01-01

Four interrelated projects are underway whose purpose is to migrate the LAMPF-PSR Accelerator Complex control systems to a system with a common set of hardware and software components. Project goals address problems in performance, maintenance and growth potential. Front-end hardware, operator interface hardware and software, computer systems, network systems and data system software are being simultaneously upgraded as part of these efforts. The efforts are being coordinated to provide for a smooth and timely migration to a client-server model-based data acquisition and control system. An increased use of distributed intelligence at both the front-end and the operator interface is a key element of the projects. (author)

Chemical resistance of core-shell particles (PS/PMMA) polymerized by seeded suspension

Energy Technology Data Exchange (ETDEWEB)

Ribeiro, Luiz Fernando Belchior; Machado, Ricardo Antonio Francisco, E-mail: ricardo.machado@ufsc.br [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil). Departamento de Engenharia de Materiais; Gonçalves, Odinei Hess [Universidade Técnológica Federal do Paraná(UTFPR), Campo Mourão, PR (Brazil); Marangoni, Cintia [Universidade Federal de Santa Catarina (UFSC), Blumenau, SC (Brazil); Motz, Günter [Lehrstuhl Keramische Werkstoffe, Universität Bayreuth (Germany)

2017-07-01

Core-shell particles were produced on seeded suspension polymerization by using polystyrene (PS) as polymer core, or seed, and methyl methacrylate (MMA) as the shell forming monomer. Two synthesis routes were evaluated by varying the PS seed conversion before MMA addition. The main purpose of this work was to investigate the influence of synthesis routes on the morphology and chemical resistance of the resulting particles. {sup 1}H NMR spectroscopy showed that the use of PS seeds with lower conversion led to the formation of higher amount of poly(styrene-co-MMA). The copolymer acted as a compatibilizer, decreasing the interfacial energy between both homopolymers. As a consequence, a larger amount of reduced PMMA cluster were formed, as was revealed by TEM measurements. Samples in this system showed enhanced resistance to cyclohexane attack compared with pure PS, with a PS extraction of only 37% after 54 hours test. (author)

Chemical resistance of core-shell particles (PS/PMMA polymerized by seeded suspension

Directory of Open Access Journals (Sweden)

Luiz Fernando Belchior Ribeiro

2017-09-01

Full Text Available Abstract Core-shell particles were produced on seeded suspension polymerization by using polystyrene (PS as polymer core, or seed, and methyl methacrylate (MMA as the shell forming monomer. Two synthesis routes were evaluated by varying the PS seed conversion before MMA addition. The main purpose of this work was to investigate the influence of synthesis routes on the morphology and chemical resistance of the resulting particles. 1H NMR spectroscopy showed that the use of PS seeds with lower conversion led to the formation of higher amount of poly(styrene-co-MMA. The copolymer acted as a compatibilizer, decreasing the interfacial energy between both homopolymers. As a consequence, a larger amount of reduced PMMA cluster were formed, as was revealed by TEM measurements. Samples in this system showed enhanced resistance to cyclohexane attack compared with pure PS, with a PS extraction of only 37% after 54 hours test.

File list: ALL.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.PSC.50.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9773...1,SRX035985,SRX1090869 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.50.AllAg.iPS_cells.bed ...

File list: ALL.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.PSC.50.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX088...16,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.50.AllAg.iPS_cells.bed ...

File list: ALL.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.PSC.20.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX088...27,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.20.AllAg.iPS_cells.bed ...

File list: ALL.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.PSC.20.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9773...30,SRX146522,SRX146547 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.20.AllAg.iPS_cells.bed ...

File list: Pol.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Pol.PSC.05.AllAg.iPS_cells mm9 RNA polymerase Pluripotent stem cell iPS cells SRX97...7435,SRX027462,SRX977434 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.05.AllAg.iPS_cells.bed ...

Accelerating dewetting on deformable substrates by adding a liquid underlayer.

Science.gov (United States)

Xu, Lin; Reiter, Günter; Shi, Tongfei; An, Lijia

2010-05-18

We investigated the dependence of the dewetting velocity of a thin, low-viscosity polystyrene (PS) top film on a poly(methyl methacrylate) (PMMA) double layer consisting of a low-viscosity underlayer of thickness h(L) coated with a high-viscosity middle layer of thickness h(M). The addition of the liquid underlayer generated complex nonmonotonic behavior of the dewetting velocity as a function of increasing h(M). In particular, we observed an acceleration of dewetting for an intermediate range of h(M). This phenomenon has been interpreted by a combination deformation of the middle elastic layer and a concurrent change in the contact angle. On one hand, deformation led to the formation of a trench that dissipated energy during its movement through the liquid underlayer and thus caused a slowing down of dewetting. However, with an increase in the thickness of the elastic middle layer, the size of the trench decreased and its influence on the dewetting velocity also decreased. On the other hand, the deformation of the elastic layer also led to an increase in the contact angle. This increase in the driving capillary forces caused an increase in the dewetting velocity.

The neutron total cross-section measurement of {sup 56}Fe and {sup 57}Fe by using Japan Proton Accelerator Research Complex facility

Energy Technology Data Exchange (ETDEWEB)

Kim, Eun Ae; Shvetsov, Valery; Cho, Moo Hyun [Pohang University of Science and Technology, Pohang (Korea, Republic of); Won, Nam Kung [Pohang Accelerator Laboratory, Pohang (Korea, Republic of); Kim, Kwang Soo; Yang, Sung Chul; Lee, Man Woo; Kim, Guin Yun [Kyungpook National University, Daegu (Korea, Republic of); Yi, Kyoung Rak; Choi, Hong Yub; Ro, Tae Ik [Dong-A University, Pusan (Korea, Republic of); Mizumoto, Motoharu; Katabuchi, Tatsuya; Igashira, Masayuki [Tokyo Institute of Technology, Tokyo (Japan)

2012-05-15

The measurement of neutron cross section using Time-Of-Flight (TOF) method gives significant information for the nuclear data research. In the present work, the neutron total cross section of {sup 56}Fe and {sup 57}Fe has been measured in the energy range between 10 eV and 100 keV by using the neutron beam produced from 3-GeV proton synchrotron accelerator. The 3-GeV proton synchrotron accelerator is located at Japan Proton Accelerator Research Complex (J-PARC) facility in Tokai village. In this study, the neutron total cross section data measured by {sup 6}Li glass scintillator detector was compared with the evaluated values of ENDF/B-VII.0

PIGMI linear-accelerator technology

International Nuclear Information System (INIS)

Boyd, T.J.; Crandall, K.R.; Hamm, R.W.

1981-01-01

A new linear-accelerator technology has been developed that makes pi-meson (pion) generation possible for cancer therapy in the setting of a major hospital center. This technology uses several new major inventions in particle accelerator science-such as a new accelerator system called the radio-frequency quadrupole (RFQ), and permanent-magnet drift-tube focusing-to substantially reduce the size, cost, and complexity of a meson factory for this use. This paper describes this technology, discusses other possible uses for these new developments, and finally discusses possible costs for such installations

Shallow PS-logging by high frequency wave; Koshuha wo mochiita senbu PS kenso

Energy Technology Data Exchange (ETDEWEB)

Nakajima, A; Miyazawa, M; Azuma, H [OYO Corp., Tokyo (Japan)

1996-05-01

This paper describes the following matters on down-hole PS logging in shallow subsurface. Determining an elastic wave velocity structure in shallow subsurface with high accuracy by using down-hole PS logging requires reduction of errors in reading travel time. Therefore, a high-frequency vibration source was fabricated with an objective to raise frequencies of waves used for the measurement. Measurements were made on two holes, A and B, at a measurement interval of 0.5 m, whereas at the hole A a measurement was performed simultaneously by using a normal type (low-frequency) vibration source. A spectral analysis on the waveform record revealed that the frequencies with each vibration source were 127 Hz and 27 Hz for the hole A, 115 Hz for the hole B, and the S/N ratio was all the same for both holes. When the high-frequency vibration source was used, the velocity was determined at accuracy of 5% over the whole length of the shallow section. When the low-frequency vibration source was used, sections with the velocity determining error greater than 5% were found, and it was not possible to derive the velocity structure in the shallow subsurface in fine segments. 3 refs., 8 figs., 2 tabs.

File list: ALL.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.PSC.10.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9774...30,SRX146524,SRX146547,SRX146522 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.10.AllAg.iPS_cells.bed ...

EDH 'Millionaire' in PS Division

CERN Multimedia

2001-01-01

Christmas cheer! Left to right: Gerard Lobeau receives a bottle of Champagne from Derek Mathieson and Jurgen De Jonghe in recognition of EDH's millionth document. At 14:33 on Monday 3 December a technician in PS division, Gerard Lobeau, unwittingly became part of an important event in the life of CERN's Electronic Document Handling system (EDH). While ordering some pieces of aluminum for one of the PS's 10Mhz RF cavities, he created EDH document number 1,000,000. To celebrate the event Derek Mathieson (EDH Project Leader) and Jurgen De Jonghe (Original EDH Project Leader) presented Mr Lobeau with a bottle of champagne. As with 93% of material requests, Mr Lobeau's order was delivered within 24 hours. 'I usually never win anything' said Mr Lobeau as he accepted his prize, 'I initially though there may have been a problem with EDH when the document number had so many zeros in it, and was then surprised to get a phone call from you a few minutes later.' The EDH team had been monitoring the EDH document number ...

Characterizing Lithospheric Thickness in Australia using Ps and Sp Scattered Waves

Science.gov (United States)

Ford, H. A.; Fischer, K. M.; Rychert, C. A.

2008-12-01

The purpose of this study is to constrain the morphology of the lithosphere-asthenosphere boundary throughout Australia using scattered waves. Prior surface wave studies have shown a correlation between lithospheric thickness and the three primary geologic provinces of Australia, with the shallowest lithosphere located beneath the Phanerozoic province to the east, and the thicker lithosphere located beneath the Proterozoic and Archean regions. To determine lithospheric thickness, waveform data from twenty permanent broadband stations spanning mainland Australia and the island of Tasmania were analyzed using Ps and Sp migration techniques. Waveform selection for each station was based on epicentral distance (35° to 80° for Ps and 55° to 80° for Sp), and event depth (no greater than 300 km for Sp). For both Ps and Sp a simultaneous deconvolution was performed on the data for each of the twenty stations, and the resulting receiver function for each station was migrated to depth. Data were binned with epicentral distance to differentiate direct discontinuity phases from crustal reverberations (for Ps) and other teleseismic arrivals (for Sp). Early results in both Ps and Sp show a clear Moho discontinuity at most stations in addition to sharp, strong crustal reverberations seen in many of the Ps images. In the eastern Phanerozoic province, a strong negative phase at 100-105 km is evident in Ps for stations CAN and EIDS. The negative phase lies within a depth range that corresponds to the negative velocity gradient between fast lithosphere and slow asthenosphere imaged by surface waves. We therefore think that it is the lithosphere- asthenosphere boundary. On the island of Tasmania, a negative phase at 70-75 km in Ps images at stations TAU and MOO also appears to be the lithosphere-asthenosphere boundary. In the Proterozoic and Archean regions of the Australian continent, initial results for both Ps and Sp migration indicate clear crustal phases, but significantly

Analüütilised voolud psühholoogias ja nende rakendamine pedagoogikas / Aleksander Elango

Index Scriptorium Estoniae

Elango, Aleksander, 1902-2004

2001-01-01

Analüütise psühholoogia kolm koolkonda - S.Freudì koolkond e. päris-psühhoanalüüs, A.Adlerì koolkond e. individuaalpsühholoogia ja C.G.Jungì psühhoanalüüsi ja individuaalpsühholoogia sünteesi luua püüdev koolkond. Analüütise psühholoogia koolkondade ja pedagoogika suhetest

Proposal for a study of laser acceleration of electrons using micrograting structures at ATF (Phase 1)

International Nuclear Information System (INIS)

Chen, W.; Claus, J.; Fernow, R.C.

1989-01-01

We propose to investigate new methods of particle acceleration using a short-pulse CO 2 laser as the power source and grating-like structures as accelerator ''cavities''. Phase I of this program is intended to demonstrate the principle of the method. We will focus the laser light to a 3 mm line on the surface of the microstructure. The structure is used to transform the electric field pattern of the incoming transversely polarized laser beam to a mode which has a component along the electron beam direction in the vicinity of the surface. With 6 mJ of laser energy and a 6 ps pulse length, the electric field in the spot will be around 1 GV/m. The electron beam from the Brookhaven Accelerator Test Facility (ATF) will be focused transversely within the few micron transverse dimension of the microstructure. The maximum expected acceleration for a 1 GV/m field and a 3 mm acceleration length is 3 MeV. 17 refs., 11 figs., 2 tabs

Human iPS Cell-Derived Germ Cells: Current Status and Clinical Potential

Directory of Open Access Journals (Sweden)

Tetsuya Ishii

2014-10-01

Full Text Available Recently, fertile spermatozoa and oocytes were generated from mouse induced pluripotent (iPS cells using a combined in vitro and in vivo induction system. With regard to germ cell induction from human iPS cells, progress has been made particularly in the male germline, demonstrating in vitro generation of haploid, round spermatids. Although iPS-derived germ cells are expected to be developed to yield a form of assisted reproductive technology (ART that can address unmet reproductive needs, genetic and/or epigenetic instabilities abound in iPS cell generation and germ cell induction. In addition, there is still room to improve the induction protocol in the female germline. However, rapid advances in stem cell research are likely to make such obstacles surmountable, potentially translating induced germ cells into the clinical setting in the immediate future. This review examines the current status of the induction of germ cells from human iPS cells and discusses the clinical potential, as well as future directions.

Electron Beam Charge Diagnostics for Laser Plasma Accelerators

International Nuclear Information System (INIS)

Nakamura, Kei; Gonsalves, Anthony; Lin, Chen; Smith, Alan; Rodgers, David; Donahue, Rich; Byrne, Warren; Leemans, Wim

2011-01-01

A comprehensive study of charge diagnostics is conducted to verify their validity for measuring electron beams produced by laser plasma accelerators (LPAs). First, a scintillating screen (Lanex) was extensively studied using subnanosecond electron beams from the Advanced Light Source booster synchrotron, at the Lawrence Berkeley National Laboratory. The Lanex was cross calibrated with an integrating current transformer (ICT) for up to the electron energy of 1.5 GeV, and the linear response of the screen was confirmed for charge density and intensity up to 160 pC/mm 2 and 0.4 pC/(ps mm 2 ), respectively. After the radio-frequency accelerator based cross calibration, a series of measurements was conducted using electron beams from an LPA. Cross calibrations were carried out using an activation-based measurement that is immune to electromagnetic pulse noise, ICT, and Lanex. The diagnostics agreed within ±8%, showing that they all can provide accurate charge measurements for LPAs.

A paralogous decoy protects Phytophthora sojae apoplastic effector PsXEG1 from a host inhibitor.

Science.gov (United States)

Ma, Zhenchuan; Zhu, Lin; Song, Tianqiao; Wang, Yang; Zhang, Qi; Xia, Yeqiang; Qiu, Min; Lin, Yachun; Li, Haiyang; Kong, Liang; Fang, Yufeng; Ye, Wenwu; Wang, Yan; Dong, Suomeng; Zheng, Xiaobo; Tyler, Brett M; Wang, Yuanchao

2017-02-17

The extracellular space (apoplast) of plant tissue represents a critical battleground between plants and attacking microbes. Here we show that a pathogen-secreted apoplastic xyloglucan-specific endoglucanase, PsXEG1, is a focus of this struggle in the Phytophthora sojae -soybean interaction. We show that soybean produces an apoplastic glucanase inhibitor protein, GmGIP1, that binds to PsXEG1 to block its contribution to virulence. P. sojae , however, secretes a paralogous PsXEG1-like protein, PsXLP1, that has lost enzyme activity but binds to GmGIP1 more tightly than does PsXEG1, thus freeing PsXEG1 to support P. sojae infection. The gene pair encoding PsXEG1 and PsXLP1 is conserved in many Phytophthora species, and the P. parasitica orthologs PpXEG1 and PpXLP1 have similar functions. Thus, this apoplastic decoy strategy may be widely used in Phytophthora pathosystems. Copyright © 2017, American Association for the Advancement of Science.

Sub One-Hundred-PS Pyroelectric Detector Research and Evaluation Program at LASL

International Nuclear Information System (INIS)

McLellan, E.J.; Stotlar, S.C.

1978-01-01

Preliminary devices have been designed and evaluated with 1 ns and 90 ps FWHM CO 2 laser pulses. Good agreement between calculated and measured values of falltime and voltage responsivity has been obtained. The female SMA to male BNC connector appears to be the most desirable easily available package for sub-one-hundred ps CO 2 laser pulses. A new detector with an expected risetime of 13 ps has been designed

Perceptions of Community Health Workers (CHWs/PS in the U.S.-Mexico Border HEART CVD Study

Directory of Open Access Journals (Sweden)

Hector G. Balcazar

2014-02-01

Full Text Available Although prior research has shown that Community Health Workers/Promotores de Salud (CHW/PS can facilitate access to care, little is known about how CHW/PS are perceived in their community. The current study reports the findings of a randomized telephone survey conducted in a high-risk urban community environment along the U.S.-Mexico border. In preparation for a community-based CHW/PS intervention called the HEART ecological study, the survey aimed to assess perceptions of CHW/PS, availability and utilization of community resources (recreational and nutrition related and health behaviors and intentions. A total of 7,155 calls were placed to complete 444 surveys in three zip codes in El Paso, Texas. Results showed that participants felt that healthful community resources were available, but utilization was low and variable: 35% reported going to a park, 20% reported having taken a health class, few reported using a gym (12%, recreation center (8%, or YMCA/YWCA (0.9%. Awareness and utilization of CHW/PS services were low: 20% of respondents had heard of CHW/PS, with 8% reporting previous exposure to CHW/PS services. Upon review of a definition of CHW/PS, respondents expressed positive views of CHW/PS and their value in the healthcare system. Respondents who had previous contact with a CHW/PS reported a significantly more positive perception of the usefulness of CHW/PS (p = 0.006, were more likely to see CHW/PS as an important link between providers and patients (p = 0.008, and were more likely to ask a CHW/PS for help (p = 0.009. Participants who utilized CHW/PS services also had significantly healthier intentions to reduce fast food intake. Future research is needed to evaluate if CHW/PS can facilitate utilization of available community resources such as recreational facilities among Hispanic border residents at risk for CVD.

LS1 Report: PS Booster prepares for beam

CERN Multimedia

Katarina Anthony

2014-01-01

With Linac2 already up and running, the countdown to beam in the LHC has begun! The next in line is the PS Booster, which will close up shop to engineers early next week. The injector will be handed over to the Operations Group who are tasked with getting it ready for active duty.   Taken as we approach the end of LS1 activities, this image shows where protons will soon be injected from Linac2 into the four PS Booster rings. Over the coming two months, the Operations Group will be putting the Booster's new elements through their paces. "Because of the wide range of upgrades and repairs carried out in the Booster, we have a very full schedule of tests planned for the machine," says Bettina Mikulec, PS Booster Engineer in Charge. "We will begin with cold checks; these are a wide range of tests carried out without beam, including system tests with power on/off and with varying settings, as well as verification of the controls system and timings." Amon...

The Brookhaven Accelerator Test Facility

International Nuclear Information System (INIS)

Batchelor, K.; Chou, T.S.; Fernow, R.C.; Fischer, J.; Gallardo, J.; Kirk, H.G.; Koul, R.; Palmer, R.B.; Pellegrini, C.; Sheehan, J.; Srinivasan-Rao, T.; Ulc, S.; Woodle, M.; Bigio, I.; Kurnit, N.; McDonald, K.T.

1989-01-01

The Brookhaven Accelerator Test Facility ATF will consist of a 50-100 MeV/c electron linac and a 100 GW CO 2 laser system. A high brightness RF-gun operating at 2,856 MHz is to be used as the injector into the linac. The RF-gun contains a Nd:Yag-laser-driven photocathode capable of producing a stream of six ps electron pulses separated by 12.5 ns. The maximum charge in a micropulse will be one nano-Coulomb. The CO 2 laser pulse length will be a few picoseconds and will be synchronized with the electron pulse. The first experimental beam is expected in Fall 89. The design electron beam parameters are given and possible initial experiments are discussed. 9 refs., 1 fig., 3 tabs

Some aspects of radiation protection near high-energy proton accelerators

CERN Document Server

Tuyn, Jan Willem Nicolaas

1977-01-01

The CERN site near Geneva borders Satigny and Meyrin in Switzerland and Saint-Genis-Pouilly and Prevention in France. The 600 MeV proton synchrocyclotron (SC) has been in operation since 1957, the 28 GeV proton synchrotron (PS) since 1960, and the Intersecting Storage Rings (ISR) since 1971. A fourth large accelerator, the 400 GeV super proton synchrotron (SPS), will soon be in service. The internal and external radiation protection problems caused by these machines, together with the solutions, are reviewed in the light of experience. (5 refs).

Design and validation of an accelerator for an ultracold electron source

Directory of Open Access Journals (Sweden)

G. Taban

2008-05-01

Full Text Available We describe here a specially designed accelerator structure and a pulsed power supply that are essential parts of a high brightness cold atoms-based electron source. The accelerator structure allows a magneto-optical atom trap to be operated inside of it, and also transmits subnanosecond electric field pulses. The power supply produces high voltage pulses up to 30 kV, with a rise time of up to 30 ns. The resulting electric field inside the structure is characterized with an electro-optic measurement and with an ion time-of-flight experiment. Simulations predict that 100 fC electron bunches, generated from trapped atoms inside the structure, reach an emittance of 0.04 mm mrad and a bunch length of 80 ps.

Microangiopathic antiphospholipid antibody syndrome due to anti-phosphatidylserine/prothrombin complex IgM antibody.

Science.gov (United States)

Senda, Yumi; Ohta, Kazuhide; Yokoyama, Tadafumi; Shimizu, Masaki; Furuichi, Kengo; Wada, Takashi; Yachie, Akihiro

2017-03-01

Herein we describe a case of microangiopathic antiphospholipid syndrome (MAPS) due to anti-phosphatidylserine/prothrombin complex (aPS/PT) IgM antibody successfully treated with rituximab. A significant correlation was observed between the clinical course and the aPS/PT IgM antibody titer, which can rise earlier before the appearance of clinical symptoms. Rituximab can be safely and effectively used for MAPS. Although detection of only aPS/PT IgM antibody is rare, aPS/PT IgM antibody might be associated with the pathogenesis of MAPS and might be a useful marker of disease activity. © 2017 Japan Pediatric Society.

File list: DNS.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available DNS.PSC.50.AllAg.iPS_cells hg19 DNase-seq Pluripotent stem cell iPS cells SRX040379...,SRX040378,SRX135563,SRX040376,SRX040377,SRX189427,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.50.AllAg.iPS_cells.bed ...

File list: His.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.PSC.50.AllAg.iPS_cells mm9 Histone Pluripotent stem cell iPS cells SRX977417,SR...RX127376,SRX146530,SRX146522,SRX146547,SRX333561,SRX035985,SRX1090869 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.50.AllAg.iPS_cells.bed ...

Density functional theory study of bulk and single-layer magnetic semiconductor CrPS4

Science.gov (United States)

Zhuang, Houlong L.; Zhou, Jia

2016-11-01

Searching for two-dimensional (2D) materials with multifunctionality is one of the main goals of current research in 2D materials. Magnetism and semiconducting are certainly two desirable functional properties for a single 2D material. In line with this goal, here we report a density functional theory (DFT) study of bulk and single-layer magnetic semiconductor CrPS4. We find that the ground-state magnetic structure of bulk CrPS4 exhibits the A-type antiferromagnetic ordering, which transforms to ferromagnetic (FM) ordering in single-layer CrPS4. The calculated formation energy and phonon spectrum confirm the stability of single-layer CrPS4. The band gaps of FM single-layer CrPS4 calculated with a hybrid density functional are within the visible-light range. We also study the effects of FM ordering on the optical absorption spectra and band alignments for water splitting, indicating that single-layer CrPS4 could be a potential photocatalyst. Our work opens up ample opportunities of energy-related applications of single-layer CrPS4.

Sofrimento psíquico e trabalho

Directory of Open Access Journals (Sweden)

Sarah Rosa Salles Vieira

2014-03-01

Full Text Available O presente artigo aprofunda questões clínico-téoricas relacionadas especificamente ao trabalho docente e ao sofrimento psíquico a ele relacionado a partir da observação clínica e vivência grupal nos atendimentos terapêuticos ocupacionais realizados no Hospital do Servidor Público Estadual de São Paulo "Francisco Morato de Oliveira" (HSPE-FMO. Partindo dos estudos acerca da Psicopatologia do Trabalho de Christophe Dejours, do trabalho docente e do relato de um caso clínico, caracteriza a problemática do sofrimento no trabalho, os sistemas de defesa contra este sofrimento, a ameaça à subjetividade do próprio trabalhador, as representações e conflitos vivenciados no trabalho docente, bem como a relação aditiva estabelecida como uma estratégia inconsciente de sobrevivência psíquica.

Optimization And Single-Shot Characterization Of Ultrashort Thz Pulses From A Laser Wakefield Accelerator

International Nuclear Information System (INIS)

Plateau, G.R.; Matlis, N.H.; van Tilborg, J.; Geddes, C.G.R.; Toth, Cs.; Schroeder, C.B.; Leemans, W.P.

2009-01-01

We present spatiotemporal characterization of μJ-class ultrashort THz pulses generated from a laser wakefield accelerator (LWFA). Accelerated electrons, resulting from the interaction of a high-intensity laser pulse with a plasma, emit high-intensity THz pulses as coherent transition radiation. Such high peak-power THz pulses, suitable for high-field (MV/cm) pump-probe experiments, also provide a non-invasive bunch-length diagnostic and thus feedback for the accelerator. The characterization of the THz pulses includes energy measurement using a Golay cell, 2D sign-resolved electro-optic measurement and single-shot spatiotemporal electric-field distribution retrieval using a new technique, coined temporal electric-field cross-Correlation (TEX). All three techniques corroborate THz pulses of ∼ 5 μJ, with peak fields of 100's of kV/cm and ∼ 0.4 ps rms duration.

Simulation and experimental studies on electron cloud effects in particle accelerators

CERN Document Server

Romano, Annalisa; Cimino, Roberto; Iadarola, Giovanni; Rumolo, Giovanni

Electron Cloud (EC) effects represent a serious limitation for particle accelerators operating with intense beams of positively charged particles. This Master thesis work presents simulation and experimental studies on EC effects carried out in collaboration with the European Organization for Nuclear Research (CERN) in Geneva and with the INFN-LNF laboratories in Frascati. During the Long Shut- down 1 (LS1, 2013-2014), a new detector for EC measurements has been installed in one of the main magnets of the CERN Proton Synchrotron (PS) to study the EC formation in presence of a strong magnetic field. The aim is to develop a reli- able EC model of the PS vacuum chamber in order to identify possible limitation for the future high intensity and high brightness beams foreseen by Large Hadron Collider (LHC) Injectors Upgrade (LIU) project. Numerical simulations with the new PyECLOUD code were performed in order to quantify the expected signal at the detector under different beam conditions. The experimental activity...

Future directions in controlling the LAMPF-PSR Accelerator Complex at Los Alamos National Laboratory

International Nuclear Information System (INIS)

Stuewe, R.; Schaller, S.; Bjorklund, E.; Burns, M.; Callaway, T.; Carr, G.; Cohen, S.; Kubicek, D.; Harrington, M.; Poore, R.; Schultz, D.

1991-01-01

Four interrelated projects are underway whose purpose is to migrate the LAMPF-PSR Accelerator Complex control systems to a system with a common set of hardware and software components. Project goals address problems in performance, maintenance and growth potential. Front-end hardware, operator interface hardware and software, computer systems, network systems and data system software are being simultaneously upgraded as part of these efforts. The efforts are being coordinated to provide for a smooth and timely migration to a client-sever model-based data acquisition and control system. An increased use of the distributed intelligence at both the front-end and operator interface is a key element of the projects. 2 refs., 2 figs

JACoW Decoupling CERN accelerators

CERN Document Server

Dworak, Andrzej

2018-01-01

The accelerator complex at CERN is a living system. Accelerators are being dismantled, upgraded or change their purpose. New accelerators are built. The changes do not happen overnight, but when they happen they may require profound changes across the handling systems. Central timings (CT), responsible for sequencing and synchronization of accelerators, are good examples of such systems. This paper shows how over the past twenty years the changes and new requirements influenced the evolution of the CTs. It describes experience gained from using the Central Beam and Cycle Manager (CBCM) CT model, for strongly coupled accelerators, and how it led to a design of a new Dynamic Beam Negotiation (DBN) model for the AD and ELENA accelerators, which reduces the coupling, increasing accelerator independence. The paper ends with an idea how to merge strong points of both models in order to create a single generic system able to efficiently handle all CERN accelerators and provide more beam time to experiments and LHC.

O Trabalho Psíquico da Intersubjetividade

Directory of Open Access Journals (Sweden)

Maria Inês Assumpção Fernandes

2003-01-01

Full Text Available O presente trabalho procura refletir sobre o trabalho psíquico da intersubjetividade nos grupos. Trata-se de pensá-lo na relação com a ruptura de investimentos durante o processo de Transformação x Criação, em primeiro lugar. A partir desse ponto, discutiremos a relação entre Transformação, Trabalho e Dispositivo. Neste caso pensamos nas possibilidades de intervenção, refletindo sobre a intervenção inpidual e a intervenção grupal. A questão da Transmissão Psíquica entre gerações será focalizada, fundamentalmente, no que se refere aos tempos lógicos do recalque.

NIKHEF: AmPS of electron beam

International Nuclear Information System (INIS)

Anon.

1992-01-01

Now operational at the Dutch National Institute for Nuclear Physics and High Energy Physics (NIKHEF), Amsterdam, is a new tool for studying the electromagnetic properties of nuclei. Called AmPS - Amsterdam pulse stretcher - this ring provides experiments with a smoother, almost continuous supply of electrons

Approach to compact terawatt CO2 laser system for particle acceleration

International Nuclear Information System (INIS)

Pogorelsky, I.V.; Kimura, W.D.; Fisher, C.H.; Kannari, F.

1994-01-01

A compact table-top 20-GW 50-ps CO 2 laser system is in operation for strong-field physics studies at the ATF. We propose scaling up of the picosecond CO 2 laser to a terawatt peak power level to meet the requirements of advanced laser accelerators. Computer modeling shows that a relatively compact single-beam picosecond CO 2 laser system with a high-pressure x-ray picosecond amplifier of a 10-cm aperture is potentially scalable to the ∼1-TW peak power level

Multichannel low power time-to-digital converter card with 21 ps precision and full scale range up to 10 μs

International Nuclear Information System (INIS)

Tamborini, D.; Portaluppi, D.; Villa, F.; Tosi, A.; Tisa, S.

2014-01-01

We present a Time-to-Digital Converter (TDC) card with a compact form factor, suitable for multichannel timing instruments or for integration into more complex systems. The TDC Card provides 10 ps timing resolution over the whole measurement range, which is selectable from 160 ns up to 10 μs, reaching 21 ps rms precision, 1.25% LSB rms differential nonlinearity, up to 3 Mconversion/s with 400 mW power consumption. The I/O edge card connector provides timing data readout through either a parallel bus or a 100 MHz serial interface and further measurement information like input signal rate and valid conversion rate (typically useful for time-correlated single-photon counting application) through an independent serial link

Multichannel low power time-to-digital converter card with 21 ps precision and full scale range up to 10 μs

Energy Technology Data Exchange (ETDEWEB)

Tamborini, D., E-mail: davide.tamborini@polimi.it; Portaluppi, D.; Villa, F.; Tosi, A. [Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, Piazza Leonardo Da Vinci 32, 20133 Milano (Italy); Tisa, S. [Micro Photon Devices, via Stradivari 4, 39100 Bolzano (Italy)

2014-11-15

We present a Time-to-Digital Converter (TDC) card with a compact form factor, suitable for multichannel timing instruments or for integration into more complex systems. The TDC Card provides 10 ps timing resolution over the whole measurement range, which is selectable from 160 ns up to 10 μs, reaching 21 ps rms precision, 1.25% LSB rms differential nonlinearity, up to 3 Mconversion/s with 400 mW power consumption. The I/O edge card connector provides timing data readout through either a parallel bus or a 100 MHz serial interface and further measurement information like input signal rate and valid conversion rate (typically useful for time-correlated single-photon counting application) through an independent serial link.

Multichannel low power time-to-digital converter card with 21 ps precision and full scale range up to 10 μs.

Science.gov (United States)

Tamborini, D; Portaluppi, D; Villa, F; Tisa, S; Tosi, A

2014-11-01

We present a Time-to-Digital Converter (TDC) card with a compact form factor, suitable for multichannel timing instruments or for integration into more complex systems. The TDC Card provides 10 ps timing resolution over the whole measurement range, which is selectable from 160 ns up to 10 μs, reaching 21 ps rms precision, 1.25% LSB rms differential nonlinearity, up to 3 Mconversion/s with 400 mW power consumption. The I/O edge card connector provides timing data readout through either a parallel bus or a 100 MHz serial interface and further measurement information like input signal rate and valid conversion rate (typically useful for time-correlated single-photon counting application) through an independent serial link.

Antibodies to phosphatidylserine/prothrombin complex as an additional diagnostic marker of APS?

Science.gov (United States)

Žigon, P; Čučnik, S; Ambrožič, A; Sodin Šemrl, S; Kveder, T; Božič, B

2012-06-01

Antiprothrombin antibodies can be measured by ELISA using either a prothrombin/phosphatidylserine complex (aPS/PT) or prothrombin alone (aPT) as antigen. We aimed to compare the clinical features of autoimmune patients with avidity of aPS/PT and determine the diagnostic efficiency of aPS/PT and aPT for assessing antiphospholipid syndrome (APS). aPS/PT were of low (n = 9), heterogeneous (n = 31) and high (n = 8) avidity out of 48 cases. None of the samples with low avidity were positive in aPT ELISA. Among patients with heterogeneous or high avidity aPS/PT, there was a significantly greater number of patients with APS as compared to patients with low avidity (38/39 vs. 7/9; p < 0.05). No SLE patients had high avidity antiprothrombin antibodies.

Look into the PS Main Control Room (partial view)

CERN Multimedia

1974-01-01

Jean-Pierre Potier at work. The 26 GeV Synchrotron and later also its related machines (Linacs 1,2,3; PS-Booster, LEP-Injector Linacs and Electron-Positron Accumulator; Antiproton Accumulator, Antiproton Collector, Low Energy Antiproton Ring and more recently Antiproton Decelerator) were all controlled from the PS control room situated at the Meyrin site. The SPS and LEP were controlled from a separat control centre on the Prevessin site. In 2005 all controls were transferred to the Prevessin centre.

Multiple bunch-splitting in the PS results and plans

CERN Document Server

Garoby, R

2001-01-01

The nominal longitudinal characteristics of the PS proton beam for the LHC were attained during the year 2000, using a sequence of triple- and double-splittings to divide each PS Booster (PSB) bunch into 12. This method minimizes longitudinal emittance blow-up and preserves a gap, free of particles, in the bunch train. Some of the ideas for alternative bunch trains have also been tested. The performance achieved is described and the sources of limitations are discussed together with the foreseen improvements.

Preliminary Specifications for the PS Transverse Damper Control Interface

CERN Document Server

Blas, A

2003-01-01

The transverse feedback system foreseen for the PS in 2004 is composed of different units to be remotely controlled and monitored: the pick-up amplifiers, the DSPU, the fine delay, the driver and power amplifiers. A special VME unit being dedicated to the pick-up amplifier ("The VMOD-TRX: a device for communication with remote instrumentation", A. Barreira Sevillano, J. Belleman, PS/BD/Note 96-02), the new interface will have to deal with the remaining parts of the loop.

Chitosan oligosaccharide-Ca complex accelerates the depuration of cadmium from Chlamys ferrari

Science.gov (United States)

Huang, Guoqing; Sun, Jipeng; Wang, Dongfeng; Xu, Ying; Xu, Wei

2012-06-01

This study investigated the effect of a chitosan oligosaccharide-Ca complex (COS-Ca) on the depuration of cadmium (Cd) from Chlamys ferrari. After exposure to 0.5 mg L-1 CdCl2 for 3 or 7 d, the scallops were treated by COS-Ca prior to determination of Cd, calcium (Ca) and zinc (Zn) contents, Cd distribution in organs, malondialdehyde (MDA) content and antioxidant variables. Results showed that COS-Ca reduced Cd content in the viscera of the scallops, with highest Cd depuration rate (47%) observed on day 3. The COS-Ca concentration substantially affected Cd depuration, and the exposure to 8.75 mg L-1 COS-Ca led to significantly higher Cd depuration rate compared with those of lower COS-Ca concentrations (1.75, 3.5, 5.25, and 7.00 mg L-1). Distribution analysis of Cd in scallop organs indicated that COS-Ca significantly reduced Cd content in the kidney throughout the 5-d experiment, as well as in the gill during the early stage of Cd depuration. In addition, COS-Ca treatment decreased glutathione peroxidase (GSH-Px) activity and MDA content while increasing superoxide dismutase (SOD) and catalase (CAT) activities on different days. Our work suggested COS-Ca complex treatment as an effective method for acceleration of Cd depuration from Cd-contaminated bivalves.

The TDCpix readout ASIC: A 75ps resolution timing front-end for the NA62 Gigatracker hybrid pixel detector

CERN Document Server

Kluge, A; Bonacini, S; Jarron, P; Kaplon, J; Morel, M; Noy, M; Perktold, L; Poltorak, K

2013-01-01

The TDCpix is a novel pixel readout ASIC for the NA62 Gigatracker detector. NA62 is a new experiment being installed at the CERN Super Proton Synchrotron. Its Gigatracker detector shall provide on-beam tracking and time stamping of individual particles with a time resolution of 150 ps rms. It will consist of three tracking stations, each with one hybrid pixel sensor. The peak fl ow of particles crossing the detector modules reaches 1.27 MHz/mm 2 for a total rate of about 0.75 GHz. Ten TDCpix chips will be bump-bonded to every silicon pixel sensor. Each chip shall perform time stamping of 100 M particle hits per second with a detection ef fi ciency above 99% and a timing accuracy better than 200 ps rms for an overall three-station-setup time resolution of better than 150 ps. The TDCpix chip has been designed in a 130 nm CMOS technology. It will feature 45 40 square pixels of 300 300 μ m 2 and a complex End of Column peripheral region including an array of TDCs based on DLLs, four high speed serializers, a low...

Positron Annihilation Ratio Spectroscopy (PsARS) Applied to Positronium Formation Studies

Science.gov (United States)

2010-03-01

Positron Annihilation Ratio Spectroscopy (PsARS). These experimental techniques have been used for a variety of military and civilian applications ... POSITRON ANNIHILATION RATIO SPECTROSCOPY (PsARS) APPLIED TO POSITRONIUM FORMATION STUDIES THESIS...of Defense, or the United States Government. AFIT/GNE/ENP/10-M07 POSITRON ANNIHILATION RATIO SPECTROSCOPY

Muon Acceleration: Neutrino Factory and Beyond

Energy Technology Data Exchange (ETDEWEB)

Bogacz, Alex [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

2018-03-01

We summarize the current state of a concept for muon acceleration aimed at a future Neutrino Factory and extendable to Higgs Factory. The main thrust of these studies was to reduce the overall cost while maintaining performance by exploring the interplay between the complexity of the cooling systems and the acceptance of the accelerator complex. To ensure adequate survival for the short-lived muons, acceleration must occur at high average gradient. The need for large transverse and longitudinal acceptances drives the design of the acceleration system to an initially low RF frequency, e.g., 325 MHz, which is then increased to 650 MHz as the transverse size shrinks with increasing energy. High-gradient normal conducting RF cavities at these frequencies require extremely high peak-power RF sources. Hence superconducting RF (SRF) cavities are chosen. We consider an SRF-efficient design based on a multi-pass (4.5) ?dogbone? RLA, extendable to multi-pass FFAG-like arcs.

Highly accelerated cardiac cine parallel MRI using low-rank matrix completion and partial separability model

Science.gov (United States)

Lyu, Jingyuan; Nakarmi, Ukash; Zhang, Chaoyi; Ying, Leslie

2016-05-01

This paper presents a new approach to highly accelerated dynamic parallel MRI using low rank matrix completion, partial separability (PS) model. In data acquisition, k-space data is moderately randomly undersampled at the center kspace navigator locations, but highly undersampled at the outer k-space for each temporal frame. In reconstruction, the navigator data is reconstructed from undersampled data using structured low-rank matrix completion. After all the unacquired navigator data is estimated, the partial separable model is used to obtain partial k-t data. Then the parallel imaging method is used to acquire the entire dynamic image series from highly undersampled data. The proposed method has shown to achieve high quality reconstructions with reduction factors up to 31, and temporal resolution of 29ms, when the conventional PS method fails.

Structure and luminescent property of complexes of aryl carboxylic acid-functionalized polystyrene with Eu(III) and Tb(III) ions.

Science.gov (United States)

Gao, Baojiao; Shi, Nan; Qiao, Zongwen

2015-11-05

Via polymer reactions, naphthoic acid (NA) and benzoic acid (BA) were bonded onto the side chains of polystyrene (PS), respectively, and two aryl carboxylic acid-functionalized polystyrenes, PSNA and PSBA, were obtained. Using PSNA and PSBA as macromolecule ligands and Eu(3+) and Tb(3+) ions as central ions, various luminescent binary polymer-rare earth complexes were prepared. At the same time, with 1,10-phenanthroline (Phen) and 4,4'-bipyridine (Bipy) as small-molecule co-ligands, various ternary polymer-rare earth complexes were also prepared. On the basis of characterizing PSNA, PSBA and complexes, the relationship between structure and luminescent property for these prepared complexes were mainly investigated. The study results show that the macromolecule ligands PSNA and PSBA, or the bonded NA and BA ligands, can strongly sensitize the fluorescence emissions of Eu(3+) ion or Tb(3+) ion, but the sensitization effect is strongly dependent on the structure of the ligands and the property of the central ions, namely it is strongly dependent on the matching degree of energy levels. The fluorescence emission of the binary complex PS-(NA)3-Eu(III) is stronger than that PS-(BA)3-Eu(III), indicating ligand NA has stronger sensitization action for Eu(3+) ion than ligand BA; the binary complex PS-(BA)3-Tb(III) emit strong characteristic fluorescence of Tb(3+) ion, displaying that ligand BA can strongly sensitize Tb(3+) ion, whereas the binary complex PS-(NA)3-Tb(III) nearly does not emit the characteristic fluorescence of Tb(3+) ion, showing that ligand NA does not sensitize Tb(3+) ion. The fluorescence intensity of the ternary complexes is much stronger than that of the binary complexes in the same series. Copyright © 2015 Elsevier B.V. All rights reserved.

Radiation protection studies for a high-power 160 MeV proton linac

CERN Document Server

Mauro, Egidio

2009-01-01

CERN is presently designing a new chain of accelerators to replace the present Proton Synchrotron (PS) complex: a 160 MeV room-temperature H− linac (Linac4) to replace the present 50 MeV proton linac injector, a 3.5 GeV Superconducting Proton Linac (SPL) to replace the 1.4 GeV PS Booster (PSB) and a 50 GeV synchrotron (named PS2) to replace the 26 GeV PS. Linac4 has been funded and the civil engineering work started in October 2008, whilst the SPL is in an advanced stage of design. Beyond injecting into the future 50 GeV PS, the ultimate goal of the SPL is to generate a 4 MW beam for the production of intense neutrino beams. The radiation protection design is driven by the latter requirement. This work summarizes the radiation protection studies conducted for Linac4. FLUKA Monte Carlo simulations, complemented by analytical estimates, were performed to evaluate the propagation of neutrons through the waveguide, ventilation and cable ducts placed along the accelerator, to estimate the radiological impact of ...

Participation of electronic excited states in the positronium formation mechanism in the Gd(III) pentakis (picrate) complexes with imidazolium countercations

Energy Technology Data Exchange (ETDEWEB)

Fulgêncio, F., E-mail: fefulgencio@gmail.com [Departam ento de Química – ICEx Universidade Federal de Minas Gerais – UFMG, Belo Horizonte, MG (Brazil); Borges, A.S. [Coordenadoria de Química e Biologia – Instituto Federal do Espírito Santos – IFES, Campus Vitória, ES (Brazil); Araújo, M.H. [Departam ento de Química – ICEx Universidade Federal de Minas Gerais – UFMG, Belo Horizonte, MG (Brazil); Brito, H.F. [Instituto de Química, Departamento de Química Fundamental, Universidade de São Paulo, São Paulo (Brazil); Oliveira, F.C. [Departamento de Metalurgia e Química, Centro Federal de Educação Tecnológica de Minas Gerais – CEFET-MG, Campus Timóteo, MG (Brazil); Ribeiro, T.; Windmöller, D. [Departam ento de Química – ICEx Universidade Federal de Minas Gerais – UFMG, Belo Horizonte, MG (Brazil); Magalhães, W.F., E-mail: welmag@ufmg.br [Departam ento de Química – ICEx Universidade Federal de Minas Gerais – UFMG, Belo Horizonte, MG (Brazil)

2016-02-15

In this work, positron annihilation lifetime (PALS) and optical spectroscopies measurements were performed on [Gd(pic){sub 2}(H{sub 2}O){sub 6}](pic)·6H{sub 2}O and on complexes of general formula C{sub 2}[Gd(pic){sub 5}], where pic corresponds to picrate ligands and C to the countercations butyl-methyl, hexyl-methyl, butyl-ethyl and butyl-butyl imidazoles. Since all of these complexes have high energy ligand-to-metal charge transfer states (LMCTS) but form low amounts of Positronium (Ps), the LMCTS do not act here as a mechanism that suppress luminescence nor prevents Ps formation. This result suggests that, besides LMCTS, other effects should also contribute to prevent Ps formation. The results indicate that the electron withdrawing –NO{sub 2} groups in the picrate ligand are responsible by the effect that prevents Ps formation. Also, a rough correlation between the ligands' triplet states lifetimes and Ps formation was observed. The insertion of electron donor groups (the imidazolium countercations) increased the ligands' first triplet excited states ({sup 3}π{sup ⁎}) lifetimes and Ps formation, indicating that these two spectroscopic parameters are correlated. Also, it is demonstrated that there is no clear correlation between Ps formation probability and the excitation energy of the ligands' first triplet excited states. The results were discussed in terms of the recently proposed Ps formation mechanism, named cybotactic correlated system kinetic mechanism (CCSKM), showing that the Ps formation process involves molecular excited states and is kinetically controlled. - Highlights: • PALS and optical spectroscopies measurements performed on Gd{sup 3+} complexes. • A correlation was obtained between the ligands' {sup 3}π{sup ⁎} lifetimes and Ps formation. • Electronegative groups increased the ligands' {sup 3}π{sup ⁎} lifetimes and Ps formation. • Results discussed in terms of a new Ps formation mechanism (ccskm).

Magnetic behavior of MnPS3 phases intercalated by [Zn2L]2+ (LH2: macrocyclic ligand obtained by condensation of 2-hydroxy-5-methyl-1,3-benzenedicarbaldehyde and 1,2-diaminobenzene)

International Nuclear Information System (INIS)

Spodine, E.; Valencia-Galvez, P.; Fuentealba, P.; Manzur, J.; Ruiz, D.; Venegas-Yazigi, D.; Paredes-Garcia, V.; Cardoso-Gil, R.; Schnelle, W.; Kniep, R.

2011-01-01

The intercalation of the cationic binuclear macrocyclic complex [Zn 2 L] 2+ (LH 2 : macrocyclic ligand obtained by the template condensation of 2-hydroxy-5-methyl-1,3-benzenedicarbaldehyde and 1,2-diaminobenzene) was achieved by a cationic exchange process, using K 0.4 Mn 0.8 PS 3 as a precursor. Three intercalated materials were obtained and characterized: (Zn 2 L) 0.05 K 0.3 Mn 0.8 PS 3 (1), (Zn 2 L) 0.1 K 0.2 Mn 0.8 PS 3 (2) and (Zn 2 L) 0.05 K 0.3 Mn 0.8 PS 3 (3), the latter phase being obtained by an assisted microwave radiation process. The magnetic data permit to estimate the Weiss temperature θ of ∼-130 K for (1); ∼-155 K for (2) and ∼-130 K for (3). The spin canting present in the potassium precursor remains unperturbed in composite (3), and spontaneous magnetization is observed under 50 K in both materials. However composites (1) and (2) do not present this spontaneous magnetization at low temperatures. The electronic properties of the intercalates do not appear to be significantly altered. The reflectance spectra of the intercalated phases (1), (2) and (3) show a gap value between 1.90 and 1.80 eV, lower than the value observed for the K 0.4 Mn 0.8 PS 3 precursor of 2.8 eV. -- Graphical Abstract: Microwave assisted synthesis was used to obtain an intercalated MnPS 3 phase with a binuclear Zn(II) macrocyclic complex. A comparative magnetic study of the composites obtained by assisted microwave and traditional synthetic methods is reported. Display Omitted Highlights: → A rapid and efficient preparation of intercalated MnPS 3 composites by assisted microwave synthesis is described. → The exchange of potassium ions of the precursor by the macrocyclic Zn(II) complex is partial. → The composite obtained by assisted microwave synthesis retains the spontaneous magnetization, observed in the low temperature range of the magnetic susceptibility of the potassium precursor. → The materials obtained by the conventional method loose the spontaneous

Network structure control of binary mixed langmuir monolayers of homo-PS and PS-b-P2VP.

Science.gov (United States)

Wen, Gangyao

2010-03-25

Our recent work showed there existed a composition window for mixed Langmuir monolayers of homopolystyrene (h-PS) and a symmetric diblock copolymer polystyrene-block-poly(2-vinylpyridine) (PS-b-P2VP) to form necklace-network structures at the air/water interface. In order to study further the possible mechanism and control the network structure (i.e., surface coverage and nanoaggregate diameter), effects of spreading solution concentration and volume, subphase temperature, and transfer pressure on the network structure were studied by the Langmuir monolayer technique and tapping mode atomic force microscopy. With the increase of transfer pressure, there existed a novel nonlinear behavior for the nanoaggregate diameter first to increase, then to decrease, and finally to increase again, while the surface coverage tended to increase step by step. Moreover, with the elevation of temperature, chain motion between the adjoining nanoaggregates tended to be improved and thus the nanoaggregate diameter tended to be more uniform.

LIGHT - from laser ion acceleration to future applications

Science.gov (United States)

Roth, Markus; Light Collaboration

2013-10-01

Creation of high intensity multi-MeV ion bunches by high power lasers became a reliable tool during the last 15 years. The laser plasma source provides for TV/m accelerating field gradients and initially sub-ps bunch lengths. However, the large envelope divergence and the continuous exponential energy spectrum are substential drawbacks for many possible applications. To face this problem, the LIGHT collaboration was founded (Laser Ion Generation, Handling and Transport). The collaboration consists of several university groups and research centers, namely TU Darmstadt, JWGU Frankfurt, HI Jena, HZDR Dresden and GSI Darmstadt. The central goal is building a test beamline for merging laser ion acceleration with conventional accelerator infrastructure at the GSI facility. In the latest experiments, low divergent proton bunches with a central energy of up to 10 MeV and containing >109 particles could be provided at up to 2.2 m behind the plasma source, using a pulsed solenoid. In a next step, a radiofrequency cavity will be added to the beamline for phase rotation of these bunches, giving access to sub-ns bunch lengths and reaching highest intensities. An overview of the LIGHT objectives and the recent experimental results will be given. This work was supported by HIC4FAIR.

The development of the Asian Forum for Polar Sciences (AFoPS)

Science.gov (United States)

Kim, Yeadong; Jeong, Jihoon

2015-12-01

The Asian Forum for Polar Sciences (AFoPS), an international forum of Asian polar research institutes, was established for the advancement of polar sciences among its members in 2004. The Forum has served as an important medium of Asian collective endeavors for polar affairs in human and information exchange, research collaboration, and logistics cooperation for the last decade. The historical development of the AFoPS in retrospect can be divided into four phases: inception and establishment (2003-2004), growth and expansion (2005-2007), review and restructuring (2008-2011), and achievements and further measures (2012-2014). The progress of the AFoPS has not been linear and this trend will continue into the next decades. The Forum, however, clearly made achievements in this period of time, realizing multilateral research and logistics cooperation that would have been previously unimaginable; by doing so, it has laid the foundation for the future. Responsible for a great portion of the world's polar activities, the AFoPS will rise to meet the expectations of the world by producing notable research output, initiating international cooperative programs, and supporting non-polar Asian countries with education and research collaboration. These are the tasks of the AFoPS for the next decade and they require strategy that promotes and facilitates collaboration in a practical way and draws attention of non-polar Asian countries to the polar sciences.

X-ray spectroscopy of the photosynthetic oxygen-evolving complex

Energy Technology Data Exchange (ETDEWEB)

Sauer, Ken; Yano, Junko; Yachandra, Vittal K

2007-04-05

Water oxidation to dioxygen in photosynthesis is catalyzed by a Mn4Ca cluster with O bridging in Photosystem II (PS II) of plants, algae and cyanobacteria. A variety of spectroscopic methods have been applied to analyzing the participation of the complex. X-ray spectroscopy is particularly useful because it is element-specific, and because it can reveal important structural features of the complex with high accuracy and identify the participation of Mn in the redox chemistry. Following a brief history of the application of X-ray spectroscopy to PS II, an overview of newer results will be presented and a description of the present state of our knowledge based on this approach.

Paper sludge (PS) to bioethanol: Evaluation of virgin and recycle mill sludge for low enzyme, high-solids fermentation.

Science.gov (United States)

Boshoff, Sonja; Gottumukkala, Lalitha Devi; van Rensburg, Eugéne; Görgens, Johann

2016-03-01

Paper sludge (PS) from the paper and pulp industry consists primarily of cellulose and ash and has significant potential for ethanol production. Thirty-seven PS samples from 11 South African paper and pulp mills exhibited large variation in chemical composition and resulting ethanol production. Simultaneous saccharification and fermentation (SSF) of PS in fed-batch culture was investigated at high solid loadings and low enzyme dosages. Water holding capacity and viscosity of the PS influenced ethanol production at elevated solid loadings of PS. High viscosity of PS from virgin pulp mills restricted the solid loading to 18% (w/w) at an enzyme dosage of 20 FPU/gram dry PS (gdPS), whereas an optimal solid loading of 27% (w/w) was achieved with corrugated recycle mill PS at 11 FPU/gdPS. Ethanol concentration and yield of virgin pulp and corrugated recycle PS were 34.2g/L at 66.9% and 45.5 g/L at 78.2%, respectively. Copyright © 2015 Elsevier Ltd. All rights reserved.

Contribution of defective PS recognition and efferocytosis to chronic inflammation and autoimmunity

Directory of Open Access Journals (Sweden)

Stanley Gititu Kimani

2014-11-01

Full Text Available Rapid and efficient clearance of apoptotic cells results in elimination of auto-antigens and provides a strong anti-inflammatory and immunosuppressive signal to prevent autoimmunity. While professional and non-professional phagocytes utilize a wide array of surface receptors to recognize apoptotic cells, recognition of phosphatidylserine (PS on apoptotic cells by PS receptors on phagocytes is emblematic signal for efferocytosis in metazoans. PS-dependent efferocytosis is associated with production of anti-inflammatory factors such as IL-10 and TGF-β that function, in part, to maintain tolerance to auto-antigens. In contrast, when apoptotic cells fail to be recognized and processed for degradation, auto-antigens persist, which can trigger immune activation leading to autoantibody production and autoimmunity. Despite the fact that genetic mouse models clearly demonstrate that loss of PS receptors can lead to age-dependent autoimmune diseases reminiscent of systemic lupus erythematosus (SLE, link between PS and defective clearance in chronic inflammation and human autoimmunity is not well delineated. In this hypothesis and theory, we review emerging questions developing in the field that may be of relevance to SLE and human autoimmunity.

An investigation into radiosensitizer mechanisms using o-Ps lifetime measurements

International Nuclear Information System (INIS)

Beling, C.D.; Smith, F.A.

1982-01-01

Lifetime measurements have been made in a number of radiosensitizer solutions as a function of both concentration and temperature. The o-Ps yields, which were corrected for chemical quenching, showed that these compounds are strong Ps inhibitors. The temperature dependence of the yields in Misonidazole/water and Misonidazole/ethanol solutions may be associated either with the different electron solvation times in the two solvents, or with changes in electron mobility. (Auth.)

JKJ accelerator timing system

International Nuclear Information System (INIS)

Ohmori, C.; Mori, Y.; Yoshii, M.; Yamamoto, M.

2001-01-01

The JKJ (JAERl-KEK Joint Project) accelerator complex consists of the linear accelerator, 3 GeV and 50 GeV synchrotrons. To minimize the beam loss during the beam transfer from the 3 GeV synchrotron to the 50 GeV one, the synchronization of the two RF system of the rings is very important. To reduce the background from the high and low momentum neutron, the neutron beam chopper will be employed. The 3 GeV RF will be also synchronized to the chopper timing when the beam goes to the neutron facility. The whole timing control system of these accelerators and chopper will be described. (author)

Stabilizing effect of a double-harmonic RF system in the CERN PS

International Nuclear Information System (INIS)

Bhat, C.; Caspers, F.; Damerau, H.; Hancock, S.; Mahner, E.; Zimmermann, F.

2009-01-01

Motivated by the discussions on scenarios for LHC upgrades, beam studies on the stability of flat bunches in a double-harmonic RF system have been conducted in the CERN Proton Synchrotron (PS). Injecting nearly nominal LHC beam intensity per cycle, 18 bunches are accelerated on harmonic h = 21 to 26GeV with the 10MHz RF system. On the flat-top, all bunches are then transformed to flat bunches by adiabatically adding RF voltage at h = 42 from a 20 MHz cavity in anti-phase to the h = 21 system. The voltage ratio V (h42)/V (h21) of about 0.5 was set according to simulations. For the next 140 ms, longitudinal profiles show stable bunches in the double-harmonic RF bucket until extraction. Without the second harmonic component, coupled-bunch oscillations are observed. The flatness of the bunches along the batch is analyzed as a measure of the relative phase error between the RF systems due to beam loading. The results of beam dynamics simulations and their comparison with the measured data are presented

Design of the New Wideband RF System for the CERN PS Booster

CERN Document Server

Paoluzzi, Mauro; Angoletta, Maria Elena; Arnaudon, Luca; Energico, Salvatore; Findlay, Alan; Haase, Matthias; Jaussi, Michael; Jones, Anthony; Landré, David; Molendijk, John; Quartullo, Danilo; Shaposhnikova, Elena

2016-01-01

For the renovation and upgrade of the CERN PS Booster (PSB) RF systems a development project was launched in 2012. The design, based on a new approach, aimed at replacing the existing tuned, narrowband RF systems with wideband, modular, solid-state driven units. A wide range of issues had to be addressed spanning from RF power production, radiation hardness of solid-state devices, active cancellation of beam-induced voltages, dedicated low-level electronics allowing multi-harmonic operation and beam stability. Following a three-year prototyping and testing campaign and two international reviews, the project endorsement came at the end of year 2015. It foresees the complete removal of present h1, h2 and h10 systems and the deployment of a new one covering all the frequency ranges from 1 MHz to 18 MHz. The four PSB rings will be equipped with 144 identical acceleration cells providing 24 kV total RF voltage per ring. This paper describes the design concepts, the retained solutions, the expected performances and...

Tribology and Microstructure of PS212 with a Cr2O3 Seal Coat

Science.gov (United States)

Sliney, Harold E.; Benoy, Patricia A.; Korenyi-Both, Andras; Dellacorte, Christopher

1994-01-01

PS212 is a plasma sprayed metal bonding chrome carbide coating with solid lubricant additives which has lubricating properties at temperatures up to about 900 deg C. The coating is diamond ground to achieve an acceptable tribological surface. But, as with many plasma spray coatings, PS212 is not fully-dense. In this study, a chromium oxide base seal coating is used in an attempt to seal any porosity that is open to the surface of the PS212 coating, and to study the effect of the sealant on the tribological properties of PS212. The results indicate that the seal coating reduces friction and wear when it is applied and then diamond ground leaving a thin layer of seal coating which fills in the surface pits of the PS212 coating.

Sapphire implant based neuro-complex for deep-lying brain tumors phototheranostics

Science.gov (United States)

Sharova, A. S.; Maklygina, YU S.; Yusubalieva, G. M.; Shikunova, I. A.; Kurlov, V. N.; Loschenov, V. B.

2018-01-01

The neuro-complex as a combination of sapphire implant optical port and osteoplastic biomaterial "Collapan" as an Aluminum phthalocyanine nanoform photosensitizer (PS) depot was developed within the framework of this study. The main goals of such neuro-complex are to provide direct access of laser radiation to the brain tissue depth and to transfer PS directly to the pathological tissue location that will allow multiple optical phototheranostics of the deep-lying tumor region without repeated surgical intervention. The developed complex spectral-optical properties research was carried out by photodiagnostics method using the model sample: a brain tissue phantom. The optical transparency of sapphire implant allows obtaining a fluorescent signal with high accuracy, comparable to direct measurement "in contact" with the tissue.

At PS170 (APPLE)

CERN Multimedia

CERN PhotoLab

1983-01-01

APPLE stands for Antiproton-Proton to Pair of LEptons (an acronym of the ancestor experiment PAPLEP), the PS170 experiment setup at LEAR to study e+e-pair production in antiproton-proton annihilation by Padova-(CEN) Saclay- Torino Collaboration. It consisted of a liquid hydrogen target surrounded by several layers of proportional chambers in the vertical field of a C-magnet (this photo), a gas Cerenkov counter, wire chambers, hodoscopes, and an electromagnetic calorimeter (see photo 8302539X, 8302540X). See also photo 8301539X for the setup assembly at an early stage.

Inversion Algorithms and PS Detection in SAR Tomography, Case Study of Bucharest City

Directory of Open Access Journals (Sweden)

C. Dănişor

2016-06-01

Full Text Available Synthetic Aperture Radar (SAR tomography can reconstruct the elevation profile of each pixel based on a set of co-registered complex images of a scene. Its main advantage over classical interferometric methods consists in the capability to improve the detection of single persistent scatterers as well as to enable the detection of multiple scatterers interfering within the same pixel. In this paper, three tomographic algorithms are compared and applied to a dataset of 32 images to generate the elevation map of dominant scatterers from a scene. Targets which present stable proprieties over time - Persistent Scatterers (PS are then detected based on reflectivity functions reconstructed with Capon filtering.

Improvement of Data Acquisition of the BRTR (PS-43) Seismic Array

Science.gov (United States)

Ozel, N. M.; Kocak, S.; Semin, K. U.; Necmioglu, O.; Destici, T. C.; Teoman, U.

2010-05-01

Bogazici University, Kandilli Observatory and Earthquake Research Institute(KOERI) is currently operating the BRTR( PS-43) seismic arrays located in the vicinity of Ankara and town Keskin, providing real-time data to IDC. PS-43 is composed of two sub-arrays, the medium-period array with a ~45km radius located in Ankara and the short-period array with ~3 km radius located in Keskin. In 2009, data availabilty of the BRTR is exceeded %98 that value is the requirment of IDC. Substantial contribution to obtain this availabiliy is implementing the improvements that mainly replacement of the grid type parabolic antennas with the heavy-duty dish antennas at necessary sites called the repeater sites RE-BRTR (CCF), RE-PS43 (Mt. Elmadag), CF-PS43 (Central Recording Building) and all MP sites. Even this renewed system is at the tentative stage, communication status of the seismic arrays are solid and continuous. BRTR is expecting another improvement, June 2010, about the power system at Mt. Elmadag and the MP site BR237. Completion of this improvement will be stabilize of our current mission.

Character of the contact and biostratigraphical feature of distribution of the microfauna on border between productive series (PS) and underlying upper Miocene sediments of Absheron oil and gas bearing region

International Nuclear Information System (INIS)

Shikhlinsky, S.A.

2002-01-01

Full text: Productive Series (PS) is a basic hydrocarbon object and has a wide distribution in the Absheron Oil and Gas Bearing Region (AOGBR).In the normal stratigraphic sequences PS lays between Akchagylian and Pontian Regiostages (Pontian).From microfauna point of view, PS contains rare native ostracods , fish teeth, otolithes and forams.In situ, in PS, there are 34 of microfauna species present and more than half of them are transitional, which appear in the Upper Miocene and finish the existence in the Akchagylian-Apsheronian sediments.Others taxons are having the strict stratigraphical distribution and very important for the definition of the age of different lithostratones inside PS.Stratigraphical distribution of these species has been tested in numerous natural outcrops and well sections.The large interest for geologists is the boundary between PS and underlying Upper Miocene.The stratigraphic character of the given intermediate complex of sediments depends on paleotectonic conditions and different sections on the way it is expressed differently.In one section, in other-the gradual transition from Pontian to Kalinskaya Suite (KaS).The detailed study of the samples from the numerous old explorationwells drilled before 1972 and from new contract areas located in the Caspian sea, such as Karabakh, Dan Ulduzu, Ashrafi, where sampling was made very detailed, allowed us to discover the characteristic biomarkers and to specify the character of distribution of the microfauna on the Pontian-KaS boundary.The similar contact between KaC and Pontian is observed in the Karabakh field too.KaS here is represented by monotonous carbonated shale, clay and claystone, almost not distinguished from the black Potian shale, with increase at the contact with water.Despite of it, the boundary is precisely beaten by microfauna.In the Pontian sediments we have discovered a characteristic complex of Ostracoda and microscopic Pelecypoda.

The Pan-STARRS PS1 Image Processing Pipeline

Science.gov (United States)

Magnier, E.

The Pan-STARRS PS1 Image Processing Pipeline (IPP) performs the image processing and data analysis tasks needed to enable the scientific use of the images obtained by the Pan-STARRS PS1 prototype telescope. The primary goals of the IPP are to process the science images from the Pan-STARRS telescopes and make the results available to other systems within Pan-STARRS. It also is responsible for combining all of the science images in a given filter into a single representation of the non-variable component of the night sky defined as the "Static Sky". To achieve these goals, the IPP also performs other analysis functions to generate the calibrations needed in the science image processing, and to occasionally use the derived data to generate improved astrometric and photometric reference catalogs. It also provides the infrastructure needed to store the incoming data and the resulting data products. The IPP inherits lessons learned, and in some cases code and prototype code, from several other astronomy image analysis systems, including Imcat (Kaiser), the Sloan Digital Sky Survey (REF), the Elixir system (Magnier & Cuillandre), and Vista (Tonry). Imcat and Vista have a large number of robust image processing functions. SDSS has demonstrated a working analysis pipeline and large-scale databasesystem for a dedicated project. The Elixir system has demonstrated an automatic image processing system and an object database system for operational usage. This talk will present an overview of the IPP architecture, functional flow, code development structure, and selected analysis algorithms. Also discussed is the HW highly parallel HW configuration necessary to support PS1 operational requirements. Finally, results are presented of the processing of images collected during PS1 early commissioning tasks utilizing the Pan-STARRS Test Camera #3.

Source of polarized ions for the JINR accelerator complex

Science.gov (United States)

Belov, A. S.; Donets, D. E.; Fimushkin, V. V.; Kovalenko, A. D.; Kutuzova, L. V.; Prokofichev, Yu V.; Shutov, V. B.; Turbabin, A. V.; Zubets, V. N.

2017-12-01

The JINR atomic beam type polarized ion source is described. Results of tests of the plasma ionizer with a storage cell and of tuning of high frequency transition units are presented. The source was installed in a linac injector hall of NUCLOTRON in May 2016. The source has been commissioned and used in the NUCLOTRON runs in 2016 and February - March 2017. Polarized and unpolarized deuteron beams were produced as well as polarized protons for acceleration in the NUCLOTRON. Polarized deuteron beam with pulsed current up to 2 mA has been produced. Deuteron beam polarization of 0.6-0.9 of theoretical values for different modes of high frequency transition units operation has been measured with the NUCLOTRON ring internal polarimeter for the accelerated deuteron and proton beams.

File list: ALL.PSC.20.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

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Full Text Available ALL.PSC.20.AllAg.iPS_derived_neural_cells hg19 All antigens Pluripotent stem cell iPS derived neural...hive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.20.AllAg.iPS_derived_neural_cells.bed ...

File list: His.PSC.20.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.PSC.20.AllAg.iPS_derived_neural_cells hg19 Histone Pluripotent stem cell iPS derived neural...archive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.20.AllAg.iPS_derived_neural_cells.bed ...

File list: His.PSC.50.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.PSC.50.AllAg.iPS_derived_neural_cells hg19 Histone Pluripotent stem cell iPS derived neural...archive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.50.AllAg.iPS_derived_neural_cells.bed ...

Ps beam production and scattering from gaseous targets

International Nuclear Information System (INIS)

Garner, A.J.; Laricchia, G.; Oezen, A.

1996-01-01

We have investigated the conversion of a positron beam into an ortho-Ps beam via charge exchange in gaseous H 2 , He and Ar at energies up to 120 eV and gas pressures up to 14 μmHg. H 2 has been found to be the most efficient converter at energies up to 90 eV. At higher energies, Ar has been found to be the best. Total cross sections of ortho-Ps scattering from H 2 and He have also been measured. A comparison with available theories suggests that electron exchange at lower energies and target inelastic collisions at higher energies are playing a major role in the collisions. (author)

VME Switch for CERN's PS Analog Video System

CERN Document Server

Acebes, I; Heinze, W; Lewis, J; Serrano, J

2003-01-01

Analog video signal switching is used in CERN's Proton Synchrotron (PS) complex to route the video signals coming from Beam Diagnostics systems to the Meyrin Control Room (MCR). Traditionally, this has been done with custom electromechanical relay-based cards controlled serially via CAMAC crates. In order to improve the robustness and maintainability of the system, while keeping it analog to preserve the low latency, a VME card based on Analog Devices' AD8116 analog matrix chip has been developed. Video signals go into the front panel and exit the switch through the P2 connector of the VME backplane. The module is a 16 input, 32 output matrix. Larger matrices can be built using more modules and bussing their outputs together, thanks to the high impedance feature of the AD8116. Another VME module takes the selected signals from the P2 connector and performs automatic gain to send them at nominal output level through its front panel. This paper discusses both designs and presents experimental test results.

Structure-properties relationships of polyhedral oligomeric silsesquioxane (POSS filled PS nanocomposites

Directory of Open Access Journals (Sweden)

J. J. Schwab

2012-07-01

Full Text Available The polyhedral oligomeric silsesquioxane (POSS additivated polystyrene (PS based nanocomposites were prepared by melt processing and the structure-properties relationships of the POSS-PS systems were compared to those of the neat PS. In order to investigate the effect of these structural parameters on the final properties of the polymer nanocomposites, five different kinds of POSS samples were used, in particular, POSS with different inorganic cage and with different organic pendent groups. The rheological investigation suggests clearly that the POSS acts as a plasticizer and that the processability of the PS was positively modified. The affinity between the POSS samples and the PS matrix was estimated by the calculated theoretical solubility parameters, considering the Hoy’s method and by morphology analysis. Minor difference between the solubility parameter of POSS and the matrix means better compatibility and no aggregation tendency. Furthermore, the POSS loading leads to a decrease of the rigidity, of the glass transition temperature and of the damping factor of the nanocomposite systems. The loading of different POSS molecules with open cage leads to a more pronounced effect on all the investigated properties that the loading of the POSS molecules with closed cage. Moreover, the melt properties are significantly influenced by the type of inorganic framework, by the type of the pendent organic groups and by the interaction between the POSS organic groups and the host matrix, while, the solid state properties appears to be influenced more by the kind of cage.

N-hexanoyl-L-homoserine lactone-degrading Pseudomonas aeruginosa PsDAHP1 protects zebrafish against Vibrio parahaemolyticus infection.

Science.gov (United States)

Vinoj, Gopalakrishnan; Jayakumar, Rengarajan; Chen, Jiann-Chu; Withyachumnarnkul, Boonsirm; Shanthi, Sathappan; Vaseeharan, Baskaralingam

2015-01-01

Four strains of N-hexanoyl-L-homoserine lactone (AHL)-degrading Pseudomonas spp., named PsDAHP1, PsDAHP2, PsDAHP3, and PsDAHP4 were isolated and identified from the intestine of Fenneropenaeus indicus. PsDAHP1 showed the highest AHL-degrading activity among the four isolates. PsDAHP1 inhibited biofilm-forming exopolysaccharide and altered cell surface hydrophobicity of virulent green fluorescent protein (GFP)-tagged Vibrio parahaemolyticus DAHV2 (GFP-VpDAHV2). Oral administration of PsDAHP1 significantly reduced zebrafish mortality caused by GFP-VpDAHV2 challenge, and inhibited colonisation of GFP-VpDAHV2 in the gills and intestine of zebrafish as evidence by confocal laser scanning microscope and selective plating. Furthermore, zebrafish receiving PsDAHP1-containing feed had increased phagocytic cells of its leucocytes, increased serum activities of superoxide dismutase and lysozyme. The results suggest that Pseudomonas aeruginosa PsDAHP1 could protect zebrafish from V. parahaemolyticus infection by inhibiting biofilm formation and enhancing defence mechanisms of the fish. Copyright © 2014 Elsevier Ltd. All rights reserved.

New Electron Cloud Detectors for the PS Main Magnets

CERN Document Server

Yin Vallgren, Ch; Gilardoni, S; Taborelli, M; Neupert, H; Ferreira Somoza, J

2014-01-01

Electron cloud (EC) has already been observed during normal operation of the PS, therefore it is necessary to study its in fluence on any beam instability for the future LHC Injector Upgrade (LIU). Two new electron cloud detectors have been discussed, developed and installed during the Long Shutdown (LS1) in one of the PS main magnets. The first measurement method is based on current measurement by using a shielded button-type pick-up. Due to the geometry and space limitation in the PS magnet, the button-type pick-up made of a 96%Al2O3 block coated with a thin layer of solvent-based Ag painting, placed 30 degrees to the bottom part of the vacuum chamber was installed in the horizontal direction where the only opening of the magnet coil is. The other newly developed measurement method is based on detection of photons emitted by the electrons from the electron cloud impinging on the vacuum chamber walls. The emitted photons are reected to a quartz window. A MCP-PMT (Micro-Channel Plate Photomultiplier Tube) wit...

CNA-motion in a PS - Fn

International Nuclear Information System (INIS)

Singh, M.P.; Mishra, C.K.

1989-12-01

A Finsler space Fn (n > 2), throughout with the projective curvature tensor possessing vanishing covariant derivative, has been called a ''projectively symmetric Finsler space'' and such a space is denoted PS-Fn. The conditions in which an infinitesimal transformation defines non-affine motion with a contra-field, briefly called CNA-motion, are discussed. 7 refs

Proton beam transport experiments with pulsed high-field magnets at the Dresden laser acceleration source Draco

Energy Technology Data Exchange (ETDEWEB)

Kroll, Florian; Schramm, Ulrich [Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany); Technische Universitaet Dresden, Dresden (Germany); Kraft, Stephan; Metzkes, Josefine; Schlenvoigt, Hans-Peter; Zeil, Karl [Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany)

2016-07-01

Compact laser-driven ion accelerators are a potential alternative to large and expensive conventional accelerators. High-power short-pulse lasers, impinging on e.g. thin metal foils, enable multi-MeV ion acceleration on μm length and fs to ps time scale. The generated ion bunches (typically protons) show unique beam properties, like ultra-high pulse dose. Nevertheless, laser accelerators still require substantial development in reliable beam generation and transport. Recently developed pulsed magnets meet the demands of laser acceleration and open up new research opportunities: We present a pulsed solenoid for effective collection and focusing of laser-accelerated protons that acts as link between fundamental research and application. The solenoid is powered by a capacitor-based pulse generator and can reach a maximum magnetic field of 20 T. It was installed in the target chamber of the Draco laser at HZDR. The transported beam was detected by means of radiochromic film, scintillator and Thomson parabola spectrometer. We present the characterization of the solenoid with regard to future application in radiobiological irradiation studies. Furthermore, a detailed comparison to previous experiments with a similar magnet at the PHELIX laser at GSI, Darmstadt is provided.

File list: Pol.PSC.05.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

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Full Text Available Pol.PSC.05.AllAg.iPS_derived_neural_cells hg19 RNA polymerase Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.05.AllAg.iPS_derived_neural_cells.bed ...

File list: Unc.PSC.50.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

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Full Text Available Unc.PSC.50.AllAg.iPS_derived_neural_cells hg19 Unclassified Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Unc.PSC.50.AllAg.iPS_derived_neural_cells.bed ...

File list: DNS.PSC.10.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

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Full Text Available DNS.PSC.10.AllAg.iPS_derived_neural_cells hg19 DNase-seq Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.10.AllAg.iPS_derived_neural_cells.bed ...

MYC cis-Elements in PsMPT Promoter Is Involved in Chilling Response of Paeonia suffruticosa.

Directory of Open Access Journals (Sweden)

Yuxi Zhang

Full Text Available The MPT transports Pi to synthesize ATP. PsMPT, a chilling-induced gene, was previously reported to promote energy metabolism during bud dormancy release in tree peony. In this study, the regulatory elements of PsMPT promoter involved in chilling response were further analyzed. The PsMPT transcript was detected in different tree peony tissues and was highly expressed in the flower organs, including petal, stigma and stamen. An 1174 bp of the PsMPT promoter was isolated by TAIL-PCR, and the PsMPT promoter::GUS transgenic Arabidopsis was generated and analyzed. GUS staining and qPCR showed that the promoter was active in mainly the flower stigma and stamen. Moreover, it was found that the promoter activity was enhanced by chilling, NaCl, GA, ACC and NAA, but inhibited by ABA, mannitol and PEG. In transgenic plants harboring 421 bp of the PsMPT promoter, the GUS gene expression and the activity were significantly increased by chilling treatment. When the fragment from -421 to -408 containing a MYC cis-element was deleted, the chilling response could not be observed. Further mutation analysis confirmed that the MYC element was one of the key motifs responding to chilling in the PsMPT promoter. The present study provides useful information for further investigation of the regulatory mechanism of PsMPT during the endo-dormancy release.

Preliminary Evaluation of PS300: A New Self-Lubricating High Temperature Composite Coating for Use to 800 C

Science.gov (United States)

Dellacorte, C.; Edmonds, B. J.

1995-01-01

This paper introduces PS300, a plasma sprayed, self-lubricating composite coating for use in sliding contacts at temperatures to 800 C. PS300 is a metal bonded chrome oxide coating with silver and BaF2/CaF2 eutectic solid lubricant additives. PS300 is similar to PS200, a chromium carbide based coating, which is currently being investigated for a variety of tribological applications. In pin-on-disk testing up to 650 C, PS300 exhibited comparable friction and wear properties to PS200. The PS300 matrix, which is predominantly chromium oxide rather than chromium carbide, does not require diamond grinding and polishes readily with silicon carbide abrasives greatly reducing manufacturing costs compared to PS200. It is anticipated that PS300 has potential for sliding bearing and seal applications in both aerospace and general industry.

checkCIF/PLATON report Datablock: ps75

Indian Academy of Sciences (India)

THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors found. CIF dictionary Interpreting this report. Datablock: ps75. Bond precision:.

Crystal structure of the mixed-metal thiophosphate Nb1.18V0.82PS10

Directory of Open Access Journals (Sweden)

Joobin Sun

2015-03-01

Full Text Available The mixed-metal thiophosphate, Nb1.18V0.82PS10 (niobium vanadium phosphorus decasulfide, has been prepared though solid state reactions using an alkali-metal halide flux. The title compound is isostructural with two-dimensional Nb2PS10. [M2S12] (M = Nb or V dimers built up from two bicapped trigonal prisms and tetrahedral [PS4] units share sulfur atoms to construct 1∞[M2PS10] chains along the a axis. These chains are linked through the disulfide bonds between [PS4] units in adjacent chains to form layers parallel to the ab plane. These layers then stack on top of each other to complete the three-dimensional structure with van der Waals gaps. The M sites are occupied by 59% of Nb and 41% of V and the average M—S and M—M distances in the title compound are in between those of V2PS10 and Nb2PS10. The classical charge balance of the title compound can be represented by [(Nb/V4+]2[P5+][S2−]3[S−]7.

PS3 CELL Development for Scientific Computation and Research

Science.gov (United States)

Christiansen, M.; Sevre, E.; Wang, S. M.; Yuen, D. A.; Liu, S.; Lyness, M. D.; Broten, M.

2007-12-01

The Cell processor is one of the most powerful processors on the market, and researchers in the earth sciences may find its parallel architecture to be very useful. A cell processor, with 7 cores, can easily be obtained for experimentation by purchasing a PlayStation 3 (PS3) and installing linux and the IBM SDK. Each core of the PS3 is capable of 25 GFLOPS giving a potential limit of 150 GFLOPS when using all 6 SPUs (synergistic processing units) by using vectorized algorithms. We have used the Cell's computational power to create a program which takes simulated tsunami datasets, parses them, and returns a colorized height field image using ray casting techniques. As expected, the time required to create an image is inversely proportional to the number of SPUs used. We believe that this trend will continue when multiple PS3s are chained using OpenMP functionality and are in the process of researching this. By using the Cell to visualize tsunami data, we have found that its greatest feature is its power. This fact entwines well with the needs of the scientific community where the limiting factor is time. Any algorithm, such as the heat equation, that can be subdivided into multiple parts can take advantage of the PS3 Cell's ability to split the computations across the 6 SPUs reducing required run time by one sixth. Further vectorization of the code can allow for 4 simultanious floating point operations by using the SIMD (single instruction multiple data) capabilities of the SPU increasing efficiency 24 times.