WorldWideScience

Sample records for prt 1975-1976 ridership

  1. Research report 1975/1976

    International Nuclear Information System (INIS)

    Rogers, M.D.; Lakey, J.R.A.

    1976-09-01

    The activities of the Royal Naval College, Greenwich, Department of Nuclear Science and Technology, during 1975/1976 are reported under sections entitled: general; radiation physics and technology; environmental studies; chemistry and materials; engineering research; computing; the Jason Research and Training Reactor; personal research interest. (U.K.)

  2. Annual report, 1975-1976

    International Nuclear Information System (INIS)

    1977-02-01

    This report presents the activities of the Philippine Atomic Energy Commission for fiscal year 1975-1976. One of the highlights of activities was the first Philippine Nuclear Congress held from 7-9 December 1976 at the PICC (Philippine International Convention Center). Also presented is the National Atomic Energy Plan which includes nuclear research and development covering: food supply; energy and water resources; engineering and industry; medicine; public health and nutrition; improvement of the human environment; basic objective research; and radiological surveillance of the environment. Mentioned too, are the nuclear services offered, nuclear education, nuclear regulations and safety, public acceptance of atomic energy, PAEC technical assistance program, international affairs, and staff support services

  3. Standardized Test Results: KEEP and Control Students. 1975-1976, Technical Report #69.

    Science.gov (United States)

    Antill, Ellen; Speidel, Gisela E.

    This report presents the results of various standardized measures administered to Kamehameha Early Education Program (KEEP) students and control students in the school year 1975-1976. In contrast to previous comparisons, KEEP employed more rigorous procedures for the selection of the control students and for the conditions of test administration.…

  4. Universal Esperanto Association. Annual Report 1975-1976. Esperanto Documents, New Series, No. 10A.

    Science.gov (United States)

    Universal Esperanto Association, Rotterdam (Netherlands).

    The Universal Esperanto Association publishes an annual report each year, covering April-to-April, in Esperanto. This volume presents an edited English summary of the 1975-1976 report, the aim of which is to describe UEA activities and to inform the non-speaker of the language and culture of Esperanto as they relate to the UEA's program. The…

  5. Transit ridership, reliability, and retention.

    Science.gov (United States)

    2008-10-01

    This project explores two major components that affect transit ridership: travel time reliability and rider : retention. It has been recognized that transit travel time reliability may have a significant impact on : attractiveness of transit to many ...

  6. Soil moisture transport during the 1974--1975 and 1975--1976 water years

    International Nuclear Information System (INIS)

    Last, G.V.; Easley, P.G.; Brown, D.J.

    1976-12-01

    The rate and direction of soil moisture movement in Hanford sediments were determined for the 1974-1975 and 1975-1976 water years. The data for these determinations was obtained from two large lysimeters located on the 200 area plateau near the center of the Hanford Reservation. During the 1974-75 water year, meteoric moisture percolated to a depth of 2.5 meters with a peak moisture content of 10.5 volume-percent. This percolation envelope was eliminated by evaporation during the hot dry summer of 1975. The 1975-76 water year had only 70 percent of the normal precipitation, thus the percolation envelope was small and penetrated to a depth of only two meters. However, in spite of this shallow depth and low volume of moisture, the percolation envelope was not eliminated by the end of the water year because of lower seasonal temperatures and higher humidity during the drying season. Moisture content of sediments in the 4-18 meter depth range showed no relative change throughout the two water years, and no moisture accumulated at the bottom of the lysimeters, which indicates there is no deep percolation of meteoric moisture at this site, and no recharge to the ground water

  7. El PRT-ERP y la lucha por la libertad de los presos políticos, 1971-1973

    Directory of Open Access Journals (Sweden)

    Ariel Eidelman

    2009-11-01

    Full Text Available Este trabajo aborda la represión política de la militancia revolucionaria por parte del régimen militar y la problemática de los presos políticos en la etapa 1971-1973 en Argentina. Se realiza un análisis de las principales características de la legislación represiva. Centralmente refiere a las diferentes iniciativas desarrolladas por el PRT-ERP en relación con sus militantes presos y en particular a la constitución de una Comisión de familiares de presos políticos, estudiantiles y gremiales para la organización de la solidaridad y defensa de los mismos. Apuntamos a destacar la amplia actividad de defensa y solidaridad con los presos políticos desarrollada por un conjunto de organizaciones como un antecedente importante, pero no reconocido, para la constitución del movimiento de derechos humanos de la Argentina en 1975-1976

  8. Coverage vs Frequency : Is Spatial Coverage or Temporal Frequency More Impactful on Transit Ridership?

    Science.gov (United States)

    2017-08-01

    Transit ridership has long been studied, and the findings are concisely elucidated by Taylor & Fink (2003) when they say To sum, transit ridership is largely, though not completely, a product of factors outside the control of transit managers. ...

  9. Annual report 1975-1976

    International Nuclear Information System (INIS)

    1976-01-01

    Progress, performance, and future plans are described for Canadian nuclear power plants, heavy water plants, nuclear research, commercial uses of radiation and radioisotopes, operations and administration, health protection, and collaboration with industry. (E.C.B.)

  10. PRT Impact Study Pre-PRT Phase : Volume 1. Travel Analysis.

    Science.gov (United States)

    1976-03-01

    Part of a three-volume work, this report describes the analysis performed on travel data collected for the Pre-PRT Impact Study. The data analyzed consist of travel behavior, travel patterns, model utilization and travel costs of various modes of tra...

  11. Net effects of gasoline price changes on transit ridership in U.S. urban areas.

    Science.gov (United States)

    2014-12-01

    Using panel data of transit ridership and gasoline prices for ten selected U.S. urbanized areas over the time period of 2002 to 2011, : this study analyzes the effect of gasoline prices on ridership of the four main transit modesbus, light rail, h...

  12. An econometric analysis of determinants of transit ridership : 1960-1990

    Science.gov (United States)

    1996-05-25

    This study examines the principal dterminants of the levels and changes in transit ridership for the U.S. transit operators over the 30 year period from 1960 to 1990. Transit ridership is represented by annual boardings. We would hav e preferred to h...

  13. Predicting Short-Term Subway Ridership and Prioritizing Its Influential Factors Using Gradient Boosting Decision Trees

    Directory of Open Access Journals (Sweden)

    Chuan Ding

    2016-10-01

    Full Text Available Understanding the relationship between short-term subway ridership and its influential factors is crucial to improving the accuracy of short-term subway ridership prediction. Although there has been a growing body of studies on short-term ridership prediction approaches, limited effort is made to investigate the short-term subway ridership prediction considering bus transfer activities and temporal features. To fill this gap, a relatively recent data mining approach called gradient boosting decision trees (GBDT is applied to short-term subway ridership prediction and used to capture the associations with the independent variables. Taking three subway stations in Beijing as the cases, the short-term subway ridership and alighting passengers from its adjacent bus stops are obtained based on transit smart card data. To optimize the model performance with different combinations of regularization parameters, a series of GBDT models are built with various learning rates and tree complexities by fitting a maximum of trees. The optimal model performance confirms that the gradient boosting approach can incorporate different types of predictors, fit complex nonlinear relationships, and automatically handle the multicollinearity effect with high accuracy. In contrast to other machine learning methods—or “black-box” procedures—the GBDT model can identify and rank the relative influences of bus transfer activities and temporal features on short-term subway ridership. These findings suggest that the GBDT model has considerable advantages in improving short-term subway ridership prediction in a multimodal public transportation system.

  14. Transit forecasting accuracy : ridership forecasts and capital cost estimates, final research report.

    Science.gov (United States)

    2009-01-01

    In 1992, Pickrell published a seminal piece examining the accuracy of ridership forecasts and capital cost estimates for fixed-guideway transit systems in the US. His research created heated discussions in the transit industry regarding the ability o...

  15. Reviewing, analyzing and updating marketing strategies to increase public transit ridership.

    Science.gov (United States)

    2012-01-01

    Ridership in the United States has been fluctuating over the last decade. With fuel prices : increasing, urban and suburban communities growing and global warming and environmental : impact getting special attention, it is important to increase our k...

  16. Forecasting Method for Urban Rail Transit Ridership at Station Level Using Back Propagation Neural Network

    Directory of Open Access Journals (Sweden)

    Junfang Li

    2016-01-01

    Full Text Available Direct forecasting method for Urban Rail Transit (URT ridership at the station level is not able to reflect nonlinear relationship between ridership and its predictors. Also, population is inappropriately expressed in this method since it is not uniformly distributed by area. In this paper, a new variable, population per distance band, is considered and a back propagation neural network (BPNN model which can reflect nonlinear relationship between ridership and its predictors is proposed to forecast ridership. Key predictors are obtained through partial correlation analysis. The performance of the proposed model is compared with three other benchmark models, which are linear model with population per distance band, BPNN model with total population, and linear model with total population, using four measures of effectiveness (MOEs, maximum relative error (MRE, smallest relative error (SRE, average relative error (ARE, and mean square root of relative error (MSRRE. Also, another model for contribution rate of population per distance band to ridership is formulated based on the BPNN model with nonpopulation variables fixed. Case studies with Japanese data show that BPNN model with population per distance band outperforms other three models and the contribution rate of population within special distance band to ridership calculated through the contribution rate model is 70%~92.9% close to actual statistical value. The result confirms the effectiveness of models proposed in this paper.

  17. Sandia technology, Winter 1975--1976

    International Nuclear Information System (INIS)

    Weber, J.P.; Marcrum, L.S.

    1976-06-01

    Unclassified development activities at Sandia Laboratories are described. Information is included on rocket-powered aerial trolleys, material evaluation using a plasmajet, metal-hydride models, glass-ceramic tube insulators, ferroelectric ceramics, and systems to communicate with earth penetrators

  18. Changes in Service and Associated Ridership Impacts near a New Light Rail Transit Line

    Directory of Open Access Journals (Sweden)

    Jeongwoo Lee

    2017-10-01

    Full Text Available Los Angeles (LA, for many years a city with limited rail transit, is substantially expanding its public transit system. This paradigm change in transportation policy and investment creates new requirements for monitoring. One area needing evaluation is whether new, high quality transit options, such as light rail, near existing transit services increase sustainable transportation mode shares and reduce car travel. Few studies have explored light rail’s role as a catalyst to increase overall transit use and achieve sustainability goals within an auto-oriented city like LA. Metro’s data show that trips taken on its bus and rail system dropped overall by 10.5% between 2009 and 2016, but its rail ridership grew 21% during the same period due to the debut of the Gold Line and Expo Line extensions. We analyze changes to bus service and associated ridership impacts that resulted from the opening of these two LRT lines in LA. The immediate effect of the city’s bus service changes along the Gold Line light rail extension appear to be associated with a net “bus plus rail” ridership decline in that corridor. In contrast, the Expo Line corridor experienced an initial increase in ridership during the two years immediately after its opening, possibly because the bus service was not reduced by the same magnitude as along the Gold Line extension. Our findings indicate that changes in bus service made to coincide with the introduction of new light rail transit (LRT can negatively affect the overall transit ridership in the corridor. Planners and policy makers should closely monitor changes in bus service and ridership associated with new rail transit to ensure investments results in an overall net increase in more sustainable travel.

  19. Environmental, behavioral, and psychological predictors of transit ridership: Evidence from a community intervention

    Science.gov (United States)

    Brown, Barbara B.; Werner, Carol M.; Smith, Ken R.; Tribby, Calvin P.; Miller, Harvey J.; Jensen, Wyatt A.; Tharp, Doug

    2016-01-01

    Understanding who takes advantage of new transit (public transportation) interventions is important for personal and environmental health. We examine transit ridership for residents living near a new light rail construction as part of “complete street,” pedestrian-friendly improvements. Adult residents (n=536) completed surveys and wore accelerometer and GPS units that tracked ridership before and after new transit service started. Transit riders were more physically active. Those from environments rated as more walkable were likely to be continuing transit riders. Place attachment, but not perceived physical incivilities on the path to transit, was associated with those who continued to ride or became new riders of transit. This effect was mediated through pro-city attitudes, which emphasize how the new service makes residents eager to explore areas around transit. Thus, place attachment, along with physical and health conditions, may be important predictors and promoters of transit use. PMID:27672237

  20. The Effects of Bus Ridership on Airborne Particulate Matter (PM10 Concentrations

    Directory of Open Access Journals (Sweden)

    Jaeseok Her

    2016-07-01

    Full Text Available Air pollution caused by rapid urbanization and the increased use of private vehicles seriously affects citizens’ health. In order to alleviate air pollution, many cities have replaced diesel buses with compressed natural gas (CNG buses that emit less exhaust gas. Urban planning strategies such as transit-oriented development (TOD posit that reducing private vehicle use and increasing public transportation use would reduce air pollution levels. The present study examined the effects of bus ridership on airborne particulate matter (PM10 concentrations in the capital region of Korea. We interpolated the levels of PM10 from 128 air pollution monitoring stations, utilizing the Kriging method. Spatial regression models were used to estimate the impact of bus ridership on PM10 levels, controlling for physical environment attributes and socio-economic factors. The analysis identified that PM10 concentration levels tend to be lower in areas with greater bus ridership. This result implies that urban and transportation policies designed to promote public transportation may be effective strategies for reducing air pollution.

  1. Examining the Interaction of Taxi and Subway Ridership for Sustainable Urbanization

    Directory of Open Access Journals (Sweden)

    Miaoyi Li

    2017-02-01

    Full Text Available A transit ridership study is an essential part of sustainability, and can provide a deep understanding of people’s travel patterns for efficient transportation development and urbanization. However, there is a lack of empirical studies comparing subway and taxi services, and their interactions within a city, that is to say, the interdependent transportation networks. Incorporating new data, this study aims to examine the spatial variation of urban taxi ridership due to the impacts of a new subway line operation opened in 2014 in Wuxi, China. We examine the spatial patterns and interactions of ridership in Wuxi by integrating taxi trajectory from GPS data and subway data from continuously collected fare transactions. The results indicated that the demand for taxi and subway usage is quite elastic with respect to both location and time, and the new subway’s opening had more influence on areas adjacent to subway stations and urban center-suburban travel. Furthermore, increases in travel time and distance would increase the demand for subway, while taxi trips largely represented movements for those locations that the subway could not reach. This paper betters the understanding of travel patterns through large volumes of transportation data for sustainable urbanization policy design.

  2. Is prnt a pseudogene? Identification of ram Prt in testis and ejaculated spermatozoa.

    Directory of Open Access Journals (Sweden)

    Jorge Pimenta

    Full Text Available A hallmark of prion diseases or transmissible spongiform encephalopaties is the conversion of the cellular prion protein (PrP(C, expressed by the prion gene (prnp, into an abnormally folded isoform (PrP(Sc with amyloid-like features that causes scrapie in sheep among other diseases. prnp together with prnd (which encodes a prion-like protein designated as Doppel, and prnt (that encodes the prion protein testis specific--Prt with sprn (shadow of prion protein gene, that encodes Shadoo or Sho genes, constitute the "prion gene complex". Whereas a role for prnd in the proper functioning of male reproductive system has been confirmed, the function of prnt, a recently discovered prion family gene, comprises a conundrum leading to the assumption that ruminant prnt is a pseudogene with no protein expression. The main objective of the present study was to identify Prt localization in the ram reproductive system and simultaneously to elucidate if ovine prnt gene is transcribed into protein-coding RNA. Moreover, as Prt is a prnp-related protein, the amyloid propensity was also tested for ovine and caprine Prt. Recombinant Prt was used to immunize BALB/c mice, and the anti-Prt polyclonal antibody (APPA immune response was evaluated by ELISA and Western Blot. When tested by indirect immunofluorescence, APPA showed high avidity to the ram sperm head apical ridge subdomain, before and after induced capacitation, but did not show the same behavior against goat spermatozoa, suggesting high antibody specificity against ovine-Prt. Prt was also found in the testis when assayed by immunohistochemistry during ram spermatogenesis, where spermatogonia, spermatocytes, spermatids and spermatozoa, stained positive. These observations strongly suggest ovine prnt to be a translated protein-coding gene, pointing to a role for Prt protein in the ram reproductive physiology. Besides, caprine Prt appears to exhibit a higher amyloid propensity than ovine Prt, mostly associated

  3. Characterization of a New Cell Envelope Proteinase PrtP from Lactobacillus rhamnosus CGMCC11055.

    Science.gov (United States)

    Guo, Tingting; Ouyang, Xudong; Xin, Yongping; Wang, Yue; Zhang, Susu; Kong, Jian

    2016-09-21

    Cell envelope proteinases (CEPs) play essential roles in lactic acid bacteria growth in milk and health-promoting properties of fermented dairy products. The genome of Lactobacillus rhamnosus CGMCC11055 possesses two putative CEP genes prtP and prtR2, and the PrtP displays the distinctive domain organization from PrtR2 reported. The PrtP was purified and biochemically characterized. The results showed that the optimal activity occurred at 44 °C, pH 6.5. p-Amidinophenylmethylsulfonyl fluoride obviously inhibited enzymatic activity, suggesting PrtP was a member of serine proteinases. Under the optimal conditions, β-casein was a favorite substrate over αS1- and κ-casein, and 35 oligopeptides were identified in the β-casein hydrolysate, including the phosphoserine peptide and bioactive isoleucine-proline-proline. By analysis of the amino acid sequences of those oligopeptides, proline was the preferred residue at the breakdown site. Therefore, we speculated that PrtP was a new type of CEPs from Lb. rhamnosus.

  4. Mass transit ridership and self-reported hearing health in an urban population.

    Science.gov (United States)

    Gershon, Robyn R M; Sherman, Martin F; Magda, Lori A; Riley, Halley E; McAlexander, Tara P; Neitzel, Richard

    2013-04-01

    Information on prevalence and risk factors associated with self-reported hearing health among mass transit riders is extremely limited, even though evidence suggests mass transit may be a source of excessive exposure to noise. Data on mass transit ridership were collected from 756 study participants using a self-administered questionnaire. Hearing health was measured using two symptom items (tinnitus and temporary audiometric threshold shift), two subjective measures (self-rated hearing and hearing ability), and two medical-related questions (hearing testing and physician-diagnosed hearing loss). In logistic regression analyses that controlled for possible confounders, including demographic variables, occupational noise exposure, nonoccupational noise exposure (including MP3 player use) and use of hearing protection, frequent and lengthy mass transit (all forms) ridership (1,100 min or more per week vs. 350 min or less per week) was the strongest predictor of temporary threshold shift symptoms. Noise abatement strategies, such as engineering controls, and the promotion of hearing protection use should be encouraged to reduce the risk of adverse impacts on the hearing health of mass transit users.

  5. Transcriptional and proteomic analysis of the Aspergillus fumigatus ΔprtT protease-deficient mutant.

    Science.gov (United States)

    Hagag, Shelly; Kubitschek-Barreira, Paula; Neves, Gabriela W P; Amar, David; Nierman, William; Shalit, Itamar; Shamir, Ron; Lopes-Bezerra, Leila; Osherov, Nir

    2012-01-01

    Aspergillus fumigatus is the most common opportunistic mold pathogen of humans, infecting immunocompromised patients. The fungus invades the lungs and other organs, causing severe damage. Penetration of the pulmonary epithelium is a key step in the infectious process. A. fumigatus produces extracellular proteases to degrade the host structural barriers. The A. fumigatus transcription factor PrtT controls the expression of multiple secreted proteases. PrtT shows similarity to the fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain of several transcription factors. In this work, we further investigate the function of this transcription factor by performing a transcriptional and a proteomic analysis of the ΔprtT mutant. Unexpectedly, microarray analysis revealed that in addition to the expected decrease in protease expression, expression of genes involved in iron uptake and ergosterol synthesis was dramatically decreased in the ΔprtT mutant. A second finding of interest is that deletion of prtT resulted in the upregulation of four secondary metabolite clusters, including genes for the biosynthesis of toxic pseurotin A. Proteomic analysis identified reduced levels of three secreted proteases (ALP1 protease, TppA, AFUA_2G01250) and increased levels of three secreted polysaccharide-degrading enzymes in the ΔprtT mutant possibly in response to its inability to derive sufficient nourishment from protein breakdown. This report highlights the complexity of gene regulation by PrtT, and suggests a potential novel link between the regulation of protease secretion and the control of iron uptake, ergosterol biosynthesis and secondary metabolite production in A. fumigatus.

  6. Presence of fibronectin-binding protein gene prtF2 in invasive group A streptococci in tropical Australia is associated with increased internalisation efficiency.

    Science.gov (United States)

    Gorton, Davina; Norton, Robert; Layton, Ramon; Smith, Helen; Ketheesan, Natkunam

    2005-03-01

    The fibronectin-binding proteins (FnBPs) PrtF1 and PrtF2 are considered to be major group A streptococcal virulence factors, mediating adherence to and internalisation of host cells. The present study investigated an association between the presence of prtF1 and prtF2 genes and internalisation efficiency in group A streptococci (GAS) isolated from patients with invasive disease. Of the 80 isolates tested, 58 (73%) had prtF1 and 71 (89%) possessed prtF2. Three isolates (4%) had neither gene, seven (9%) had prtF1 only, 19 (24%) had prtF2 only and 51 isolates (64%) had both prtF1 and prtF2. prtF2-positive isolates internalised up to three times more efficiently than isolates that had prtF1 alone (Pinternalisation efficiency and presence of the prtF1 gene. Analysis of the fibronectin-binding repeat domain (FBRD) of prtF2 revealed that this gene can contain 2, 3, 4 or 5 repeat regions and that five repeat regions conferred very high internalisation efficiency in invasive GAS isolates.

  7. Phenotypic and Proteomic Analysis of the Aspergillus fumigatus ΔPrtT, ΔXprG and ΔXprG/ΔPrtT Protease-Deficient Mutants

    Directory of Open Access Journals (Sweden)

    Einav Shemesh

    2017-12-01

    Full Text Available Aspergillus fumigatus is the most common mold species to cause disease in immunocompromised patients. Infection usually begins when its spores (conidia are inhaled into the airways, where they germinate, forming hyphae that penetrate and destroy the lungs and disseminate to other organs, leading to high mortality. The ability of hyphae to penetrate the pulmonary epithelium is a key step in the infectious process. A. fumigatus produces extracellular proteases that are thought to enhance penetration by degrading host structural barriers. This study explores the role of the A. fumigatus transcription factor XprG in controlling secreted proteolytic activity and fungal virulence. We deleted xprG, alone and in combination with prtT, a transcription factor previously shown to regulate extracellular proteolysis. xprG deletion resulted in abnormal conidiogenesis and formation of lighter colored, more fragile conidia and a moderate reduction in the ability of culture filtrates (CFs to degrade substrate proteins. Deletion of both xprG and prtT resulted in an additive reduction, generating a mutant strain producing CF with almost no ability to degrade substrate proteins. Detailed proteomic analysis identified numerous secreted proteases regulated by XprG and PrtT, alone and in combination. Interestingly, proteomics also identified reduced levels of secreted cell wall modifying enzymes (glucanases, chitinases and allergens following deletion of these genes, suggesting they target additional cellular processes. Surprisingly, despite the major alteration in the secretome of the xprG/prtT null mutant, including two to fivefold reductions in the level of 24 proteases, 18 glucanases, 6 chitinases, and 19 allergens, it retained wild-type virulence in murine systemic and pulmonary models of infection. This study highlights the extreme adaptability of A. fumigatus during infection based on extensive gene redundancy.

  8. Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast.

    Science.gov (United States)

    Chatterjee, Debashree; Sanchez, Ana M; Goldgur, Yehuda; Shuman, Stewart; Schwer, Beate

    2016-07-01

    Expression of fission yeast Pho1 acid phosphatase is repressed during growth in phosphate-rich medium. Repression is mediated by transcription of the prt locus upstream of pho1 to produce a long noncoding (lnc) prt RNA. Repression is also governed by RNA polymerase II CTD phosphorylation status, whereby inability to place a Ser7-PO4 mark (as in S7A) derepresses Pho1 expression, and inability to place a Thr4-PO4 mark (as in T4A) hyper-represses Pho1 in phosphate replete cells. Here we find that basal pho1 expression from the prt-pho1 locus is inversely correlated with the activity of the prt promoter, which resides in a 110-nucleotide DNA segment preceding the prt transcription start site. CTD mutations S7A and T4A had no effect on the activity of the prt promoter or the pho1 promoter, suggesting that S7A and T4A affect post-initiation events in prt lncRNA synthesis that make it less and more repressive of pho1, respectively. prt lncRNA contains clusters of DSR (determinant of selective removal) sequences recognized by the YTH-domain-containing protein Mmi1. Altering the nucleobase sequence of two DSR clusters in the prt lncRNA caused hyper-repression of pho1 in phosphate replete cells, concomitant with increased levels of the prt transcript. The isolated Mmi1 YTH domain binds to RNAs with single or tandem DSR elements, to the latter in a noncooperative fashion. We report the 1.75 Å crystal structure of the Mmi1 YTH domain and provide evidence that Mmi1 recognizes DSR RNA via a binding mode distinct from that of structurally homologous YTH proteins that recognize m(6)A-modified RNA. © 2016 Chatterjee et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  9. Savanna ecosystem project - progress report 1975/1976

    CSIR Research Space (South Africa)

    Huntley, BJ

    1977-03-01

    Full Text Available the period (684 mm) was slightly above the long-term average of 630 mm. Primary production and phytomass were measured using harvest techniques for above ground herbage, C02 gas exchange, and destructive sampling of woody plants for the determination...

  10. A Report on Educational Developments in 1975-1976. Greece.

    Science.gov (United States)

    Ministry of National Education and Religion, Athens (Greece).

    Examining the educational system of Greece, this publication discusses the reorientation of policy, organization, and curriculum after overthrow of the military regime in July 1974. In accordance with the broader democratic principles set forth in the Greek Constitution of 1975, education is now compulsory for six years, free to everyone on all…

  11. Medical and Health Sciences Division research report 1975--1976

    International Nuclear Information System (INIS)

    1976-10-01

    Progress is reported on studies on the effects of irradiation and carcinogenic chemical environmental pollutants on the immune system of mammals; fundamental studies of membrane properties and lipid metabolism in neoplasms and respiratory diseases induced by chemical irritants, carcinogens, and mutagens; the development and testing of radiopharmaceuticals labeled with 11 C, 67 Ga, 157 Dy, or 171 Er as tumor-localizing agents; and the completion of a radiation emergency assistance center and training program. A list is included of 60 publications during the period covered by this report that give details of the studies

  12. Simultaneous Presence of PrtH and PrtH2 Proteinases in Lactobacillus helveticus Strains Improves Breakdown of the Pure αs1-Casein▿ †

    Science.gov (United States)

    Sadat-Mekmene, L.; Jardin, J.; Corre, C.; Mollé, D.; Richoux, R.; Delage, M.-M.; Lortal, S.; Gagnaire, V.

    2011-01-01

    Lactobacillus helveticus can possess one or two cell envelope proteinases (CEPs), called PrtH2 and PrtH. The aim of this work was to explore the diversity of 15 strains of L. helveticus, isolated from various origins, in terms of their proteolytic activities and specificities on pure caseins or on milk casein micelles. CEP activity differed 14-fold when the strains were assayed on a synthetic substrate, but no significant differences were detected between strains possessing one or two CEPs. No correlation was observed between the proteolytic activities of the strains and their rates of acidification in milk. The kinetics of hydrolysis of purified αs1- and β-casein by L. helveticus whole cells was monitored using Tris-Tricine sodium dodecyl sulfate (SDS) electrophoresis, and for four strains, the peptides released were identified using mass spectrometry. While rapid hydrolysis of pure β-casein was observed for all strains, the hydrolysis kinetics of αs1-casein was the only criterion capable of distinguishing between the strains based on the number of CEPs. Fifty-four to 74 peptides were identified for each strain. When only PrtH2 was present, 22 to 30% of the peptides originated from αs1-casein. The percentage increased to 41 to 49% for strains in which both CEPs were expressed. The peptide size ranged from 6 to 33 amino acids, revealing a broad range of cleavage specificities, involving all classes of amino acids (Leu, Val, Ala, Ile, Glu, Gln, Lys, Arg, Met, and Pro). Regions resistant to proteolysis were identified in both caseins. When strains were grown in milk, a drastic reduction in the number of peptides was observed, reflecting changes in accessibility and/or peptide assimilation during growth. PMID:21037305

  13. CpxR-Dependent Thermoregulation of Serratia marcescens PrtA Metalloprotease Expression and Its Contribution to Bacterial Biofilm Formation.

    Science.gov (United States)

    Bruna, Roberto E; Molino, María Victoria; Lazzaro, Martina; Mariscotti, Javier F; García Véscovi, Eleonora

    2018-04-15

    PrtA is the major secreted metalloprotease of Serratia marcescens Previous reports implicate PrtA in the pathogenic capacity of this bacterium. PrtA is also clinically used as a potent analgesic and anti-inflammatory drug, and its catalytic properties attract industrial interest. Comparatively, there is scarce knowledge about the mechanisms that physiologically govern PrtA expression in Serratia In this work, we demonstrate that PrtA production is derepressed when the bacterial growth temperature decreases from 37°C to 30°C. We show that this thermoregulation occurs at the transcriptional level. We determined that upstream of prtA , there is a conserved motif that is directly recognized by the CpxR transcriptional regulator. This feature is found along Serratia strains irrespective of their isolation source, suggesting an evolutionary conservation of CpxR-dependent regulation of PrtA expression. We found that in S. marcescen s, the CpxAR system is more active at 37°C than at 30°C. In good agreement with these results, in a cpxR mutant background, prtA is derepressed at 37°C, while overexpression of the NlpE lipoprotein, a well-known CpxAR-inducing condition, inhibits PrtA expression, suggesting that the levels of the activated form of CpxR are increased at 37°C over those at 30°C. In addition, we establish that PrtA is involved in the ability of S. marcescens to develop biofilm. In accordance, CpxR influences the biofilm phenotype only when bacteria are grown at 37°C. In sum, our findings shed light on regulatory mechanisms that fine-tune PrtA expression and reveal a novel role for PrtA in the lifestyle of S. marcescens IMPORTANCE We demonstrate that S. marcescens metalloprotease PrtA expression is transcriptionally thermoregulated. While strongly activated below 30°C, its expression is downregulated at 37°C. We found that in S. marcescens , the CpxAR signal transduction system, which responds to envelope stress and bacterial surface adhesion, is

  14. Impacts of public transit improvements on ridership, and implications for physical activity, in a low-density Canadian city.

    Science.gov (United States)

    Collins, Patricia A; Agarwal, Ajay

    2015-01-01

    Public transit ridership offers valuable opportunities for modest amounts of daily physical activity (PA). Transit is a more feasible option for most Canadian commuters who live too far from work to walk or cycle, yet public transit usage in midsized Canadian cities has historically remained low due to inefficient transit service. The objectives of this longitudinal study were threefold: to assess whether the introduction of express transit service in the low-density city of Kingston, Ontario, has translated to greater transit use among a targeted employee group; to document the characteristics of those employees that have shifted to transit; and to examine the PA levels of employees using transit compared to other commute modes. An online survey was administered in October 2013 and October 2014 to all non-student employees at Queen's University. 1356 employees completed the survey in 2013, and 1123 in 2014; 656 of these employees completed the survey both years, constituting our longitudinal sample. Year-round transit ridership increased from 5.5% in 2013 to 8.5% in 2014 (p transit had fewer household-level opportunities to drive to work and more positive attitudes toward transit. Transit commuters accrued an average of 80 minutes/week of commute-related PA, and 50 minutes/week more total PA than those that commuted entirely passively. Kingston Transit's express service has stimulated an increase in transit ridership among one of their target employers, Queen's University. The findings from this study suggest that shifting to transit from entirely passive commuting can generate higher overall PA levels.

  15. Research on strategy and optimization method of PRT empty vehicles resource allocation based on traffic demand forecast

    Science.gov (United States)

    Xiang, Yu; Tao, Cheng

    2018-05-01

    During the operation of the personal rapid transit system(PRT), the empty vehicle resources is distributed unevenly because of different passenger demand. In order to maintain the balance between supply and demand, and to meet the passenger needs of the ride, PRT empty vehicle resource allocation model is constructed based on the future demand forecasted by historical demand in this paper. The improved genetic algorithm is implied in distribution of the empty vehicle which can reduce the customers waiting time and improve the operation efficiency of the PRT system so that all passengers can take the PRT vehicles in the shortest time. The experimental result shows that the improved genetic algorithm can allocate the empty vehicle from the system level optimally, and realize the distribution of the empty vehicle resources reasonably in the system.

  16. Transformation of PRT6 RNAi construct into tomato (Solanum lycopersicum) cv. Micro-Tom

    Science.gov (United States)

    Suka, Intan Elya; Chew, Bee Lynn; Goh, Hoe-Han; Isa, Nurulhikma Md

    2018-04-01

    PROTEOLYSIS 6 plays major role in the N-end rule pathway as N-recognin which functions as E3 ligase enzyme. It mediates ubiquitin processes that lead to degradation of unstable substrate protein. The aim of the current study is to transform the PRT6 gene into tomato (Solanum lycopersicum) from the cultivar Micro-Tom and to investigate its function in regulating ripening in tomato fruits. The PRT6_RNAi construct was successfully transformed into Agrobacterium C58 via heat shock method and transformed into seven days old cotyledon explants. Factors affecting transformation efficiency such as co-cultivation time and type of plant growth regulator combination were evaluated. Results from this study found that pre-cultured cotyledons from seven days old seedlings incubated for 2 days in co-cultivation medium increased shoot regeneration. Plant growth hormones zeatin combine with auxin produced a higher number of callus formation but lower shoot proliferation and transformation frequency compared to treatments of single plant hormone in the selection medium. Polymerase chain reaction (PCR) was performed on the regenerated shoots to confirm the integration of PRT6 fragment into the genome of transgenic plants. Based on PCR analysis, all putative shoots were positive transformants.

  17. The Secreted Protease PrtA Controls Cell Growth, Biofilm Formation and Pathogenicity in Xylella fastidiosa.

    Science.gov (United States)

    Gouran, Hossein; Gillespie, Hyrum; Nascimento, Rafael; Chakraborty, Sandeep; Zaini, Paulo A; Jacobson, Aaron; Phinney, Brett S; Dolan, David; Durbin-Johnson, Blythe P; Antonova, Elena S; Lindow, Steven E; Mellema, Matthew S; Goulart, Luiz R; Dandekar, Abhaya M

    2016-08-05

    Pierce's disease (PD) is a deadly disease of grapevines caused by the Gram-negative bacterium Xylella fastidiosa. Though disease symptoms were formerly attributed to bacteria blocking the plant xylem, this hypothesis is at best overly simplistic. Recently, we used a proteomic approach to characterize the secretome of X. fastidiosa, both in vitro and in planta, and identified LesA as one of the pathogenicity factors of X. fastidiosa in grapevines that leads to leaf scorching and chlorosis. Herein, we characterize another such factor encoded by PD0956, designated as an antivirulence secreted protease "PrtA" that displays a central role in controlling in vitro cell proliferation, length, motility, biofilm formation, and in planta virulence. The mutant in X. fastidiosa exhibited reduced cell length, hypermotility (and subsequent lack of biofilm formation) and hypervirulence in grapevines. These findings are supported by transcriptomic and proteomic analyses with corresponding plant infection data. Of particular interest, is the hypervirulent response in grapevines observed when X. fastidiosa is disrupted for production of PrtA, and that PD-model tobacco plants transformed to express PrtA exhibited decreased symptoms after infection by X. fastidiosa.

  18. Interaction of the RNP1 motif in PRT1 with HCR1 promotes 40S binding of eukaryotic initiation factor 3 in yeast

    DEFF Research Database (Denmark)

    Nielsen, Klaus H; Valásek, Leos; Sykes, Caroah

    2006-01-01

    We found that mutating the RNP1 motif in the predicted RRM domain in yeast eukaryotic initiation factor 3 (eIF3) subunit b/PRT1 (prt1-rnp1) impairs its direct interactions in vitro with both eIF3a/TIF32 and eIF3j/HCR1. The rnp1 mutation in PRT1 confers temperature-sensitive translation initiation...

  19. Characterization of an extensin-modifying metalloprotease: N-terminal processing and substrate cleavage pattern of Pectobacterium carotovorum Prt1.

    Science.gov (United States)

    Feng, Tao; Nyffenegger, Christian; Højrup, Peter; Vidal-Melgosa, Silvia; Yan, Kok-Phen; Fangel, Jonatan Ulrik; Meyer, Anne S; Kirpekar, Finn; Willats, William G; Mikkelsen, Jørn D

    2014-12-01

    Compared to other plant cell wall-degrading enzymes, proteases are less well understood. In this study, the extracellular metalloprotease Prt1 from Pectobacterium carotovorum (formerly Erwinia carotovora) was expressed in Escherichia coli and characterized with respect to N-terminal processing, thermal stability, substrate targets, and cleavage patterns. Prt1 is an autoprocessing protease with an N-terminal signal pre-peptide and a pro-peptide which has to be removed in order to activate the protease. The sequential cleavage of the N-terminus was confirmed by mass spectrometry (MS) fingerprinting and N-terminus analysis. The optimal reaction conditions for the activity of Prt1 on azocasein were at pH 6.0, 50 °C. At these reaction conditions, K M was 1.81 mg/mL and k cat was 1.82 × 10(7) U M(-1). The enzyme was relatively stable at 50 °C with a half-life of 20 min. Ethylenediaminetetraacetic acid (EDTA) treatment abolished activity; Zn(2+) addition caused regain of the activity, but Zn(2+)addition decreased the thermal stability of the Prt1 enzyme presumably as a result of increased proteolytic autolysis. In addition to casein, the enzyme catalyzed degradation of collagen, potato lectin, and plant extensin. Analysis of the cleavage pattern of different substrates after treatment with Prt1 indicated that the protease had a substrate cleavage preference for proline in substrate residue position P1 followed by a hydrophobic residue in residue position P1' at the cleavage point. The activity of Prt1 against plant cell wall structural proteins suggests that this enzyme might become an important new addition to the toolbox of cell-wall-degrading enzymes for biomass processing.

  20. Mirasol PRT system inactivation efficacy evaluated in platelet concentrates by bacteria-contamination model

    Directory of Open Access Journals (Sweden)

    Jocić Miodrag

    2011-01-01

    Full Text Available Background/Aim. Bacterial contamination of blood components, primarily platelet concentrates (PCs, has been identified as one of the most frequent infectious complications in transfusion practice. PC units have a high risk for bacterial growth/multiplication due to their storage at ambient temperature (20 ± 2°C. Consequences of blood contamination could be effectively prevented or reduced by pathogen inactivation systems. The aim of this study was to determine the Mirasol pathogen reduction technology (PRT system efficacy in PCs using an artificial bacteria-contamination model. Methods. According to the ABO blood groups, PC units (n = 216 were pooled into 54 pools (PC-Ps. PC-Ps were divided into three equal groups, with 18 units in each, designed for an artificial bacteria-contamination. Briefly, PC-Ps were contaminated by Staphylococcus epidermidis, Staphylococcus aureus or Escherichia coli in concentrations 102 to 107 colony forming units (CFU per unit. Afterward, PC-Ps were underwent to inactivation by Mirasol PRT system, using UV (l = 265-370 nm activated riboflavin (RB. All PC-Ps were assayed by BacT/Alert Microbial Detection System for CFU quantification before and after the Mirasol treatment. Samples from non-inactivated PC-P units were tested after preparation and immediately following bacterial contamination. Samples from Mirasol treated units were quantified for CFUs one hour, 3 days and 5 days after inactivation. Results. A complete inactivation of all bacteria species was obtained at CFU concentrations of 102 and 103 per PC-P unit through storage/ investigation period. The most effective inactivation (105 CFU per PC-P unit was obtained in Escherichia coli setting. Contrary, inactivation of all the three tested bacteria species was unworkable in concentrations of ≥ 106 CFU per PC-P unit. Conclusion. Efficient inactivation of investigated bacteria types with a significant CFU depletion in PC-P units was obtained - 3 Log for all

  1. Characterization of an extensin-modifying metalloprotease: N-terminal processing and substrate cleavage pattern of Pectobacterium carotovorum Prt1

    DEFF Research Database (Denmark)

    Feng, Tao; Nyffenegger, Christian; Højrup, Peter

    2014-01-01

    Compared to other plant cell wall-degrading enzymes, proteases are less well understood. In this study, the extracellular metalloprotease Prt1 from Pectobacterium carotovorum (formerly Erwinia carotovora) was expressed in Escherichia coli and characterized with respect to N-terminal processing...

  2. Survey for collagenase gene prtC in Porphyromonas gingivalis and Porphyromonas endodontalis isolated from endodontic infections.

    Science.gov (United States)

    Odell, L J; Baumgartner, J C; Xia, T; David, L L

    1999-08-01

    Collagenase is a potential virulence factor shown to be expressed by Porphyromonas gingivalis associated with periodontal disease. The purpose of this study was to use the polymerase chain reaction (PCR) to detect the presence of the collagenase gene (prtC) in 21 strains of Porphyromonas species isolated from endodontic infections. Type strains for P. gingivalis (ATCC 33277), P. endodontalis (ATCC 35406), Prevotella intermedia (ATCC 25611), and Prevotella nigrescens (ATCC 33563) were used as controls. When PCR primers specific for the 16S ribosomal RNA gene of P. gingivalis or P. endodontalis were used, 16 of the strains were identified as P. gingivalis, and five strains were identified as P. endodontalis. The presence of the prtC gene for collagenase was detected using PCR. Amplicons were analyzed by agarose gel electrophoresis, with an 815 bp amplicon representing the presence of the collagenase gene. Type strain ATCC 33277 and all 16 clinical isolates of P. gingivalis produced the collagenase gene amplicon. Neither type strain ATCC 35406 nor the five strains from clinical isolates of P. endodontalis produced the collagenase gene amplicon. These results indicate that P. gingivalis from endodontic infections possesses the prtC gene. P. endodontalis does not seem to exhibit prtC. The virulence of P. gingivalis may be related to its production of collagenase.

  3. ETR fuel element shipping container addendum to PR-T-79-011 (TR-466). Internal technical report

    International Nuclear Information System (INIS)

    Smith, M.C.

    1979-01-01

    In July, 1979, EG and G Idaho, Inc. was requested to evaluate the ETR Fuel Element Shipping Container for compliance with existing transport regulations, in order to ship GETR fuel elements from Vallecitos, California to the INEL. Technical report PR-T-79-011 (TR-466), ATR Fuel Element Shipping Container Safety Analysis, was used as a basis for this evaluation. The safety analysis contained in technical report PR-T-79-011 (TR-466) was performed utilizing the ATR, ETR, MTR, and SPERT shipping containers. The report determined the ETR Fuel Element Shipping Container does comply with the existing transport regulations for a Type A quantity, Fissile Class I shipping container. The ETR and GETR fuel elements are essentially identical in physical size, construction, and fissile material content, the analysis documented in this report has determined the shipment of GETR fuel elements in the ETR shipping container to be safe and pose no threat to the public health and safety

  4. The S-layer Associated Serine Protease Homolog PrtX Impacts Cell Surface-Mediated Microbe-Host Interactions of Lactobacillus acidophilus NCFM

    Directory of Open Access Journals (Sweden)

    Brant R. Johnson

    2017-06-01

    Full Text Available Health-promoting aspects attributed to probiotic microorganisms, including adhesion to intestinal epithelia and modulation of the host mucosal immune system, are mediated by proteins found on the bacterial cell surface. Notably, certain probiotic and commensal bacteria contain a surface (S- layer as the outermost stratum of the cell wall. S-layers are non-covalently bound semi-porous, crystalline arrays of self-assembling, proteinaceous subunits called S-layer proteins (SLPs. Recent evidence has shown that multiple proteins are non-covalently co-localized within the S-layer, designated S-layer associated proteins (SLAPs. In Lactobacillus acidophilus NCFM, SLP and SLAPs have been implicated in both mucosal immunomodulation and adhesion to the host intestinal epithelium. In this study, a S-layer associated serine protease homolog, PrtX (prtX, lba1578, was deleted from the chromosome of L. acidophilus NCFM. Compared to the parent strain, the PrtX-deficient strain (ΔprtX demonstrated increased autoaggregation, an altered cellular morphology, and pleiotropic increases in adhesion to mucin and fibronectin, in vitro. Furthermore, ΔprtX demonstrated increased in vitro immune stimulation of IL-6, IL-12, and IL-10 compared to wild-type, when exposed to mouse dendritic cells. Finally, in vivo colonization of germ-free mice with ΔprtX led to an increase in epithelial barrier integrity. The absence of PrtX within the exoproteome of a ΔprtX strain caused morphological changes, resulting in a pleiotropic increase of the organisms’ immunomodulatory properties and interactions with some intestinal epithelial cell components.

  5. Technological and Genomic Analysis of Roles of the Cell-Envelope Protease PrtS in Yoghurt Starter Development

    Directory of Open Access Journals (Sweden)

    Hui Tian

    2018-04-01

    Full Text Available The cell-envelope protease PrtS was proved to be efficient in optimal bacterial growth and fast acidification in pure culture, while its positive effect on the performance of mixed-cultures in milk fermentation was not defined. The aim was to analyze effects of the PrtS on the symbiosis between strains during yoghurt production and cold storage. Two Streptococcus thermophilus strains, KLDS3.1012 and KLDS SM, and two different proteolytic strains of Lactobacillus delbrueckii subsp. Bulgaricus, L7 and L12, were used. Technological properties (viability, acid production, and proteolysis were determined. Comparative genomics was used to analyze the proteolytic system (cell-envelope protease, transport system, intracellular peptidase of Streptococcus thermophilus strains. S. thermophilus KLDS SM possesses an intact gene encoding PrtS (A9497_00420, which was not found in the genome of S. thermophilus KLDS3.1012. This gene is the main difference in the proteolytic system between the two genomes. PrtS endowed KLDS SM high levels of viability during fermentation and cold storage. When combined with a weaker lactobacillus strain during fermentation, the acceleration of acid production of mixed-culture by KLDS SM would start at an earlier time. KLDS SM increased the post-acidification of yoghurts during cold storage, but the pH was steadily maintained during 14–28 days. Results suggest that strains of Streptococcus thermophilus with strong proteolytic ability could be used in a wide range of dairy production. The present study provided data for yoghurt starter development from the point of view of proteolysis.

  6. Network-based model for predicting the effect of fuel price on transit ridership and greenhouse gas emissions

    Directory of Open Access Journals (Sweden)

    Michael W. Levin

    2017-12-01

    Full Text Available As fuel prices increase, drivers may make travel choices to minimize not only travel time, but also fuel consumption. Consideration of fuel consumption would affect route choice and influence trip frequency and mode choice. For instance, travelers may elect to live closer to their workplace, or use public transit to avoid fuel consumption and the associated costs. To incorporate network characteristics into predictions of the effects of fuel prices, we develop a multi-class combined elastic demand, mode choice, and user equilibrium model using a generalized cost function of travel time and fuel consumption with a combined solution algorithm. The algorithm is implemented in a custom software package, and a case study application on the Austin, Texas network is presented. We evaluate the fuel-price sensitivity of key variables such as drive-alone and transit class proportions, person-miles traveled, link-level traffic flow and per capita fuel consumption and emissions. These effects are examined across a heterogeneous demand set, with multiple user-classes categorized based on their value of travel time. The highest relative transit elasticities against fuel price are observed among low value of time classes, as expected. Although total personal vehicle travel decreases, congestion increases on some roads due to the generalized cost function. Reductions in system-wide fuel consumption and greenhouse gas emissions are observed as well. The study uncovers the combined interactions among fuel prices, multi-modal choice behavior, travel performance, and resultant environmental impacts, all of which dictate the urban travel market. It also equips agencies with motivation to tailor emissions reduction and transit-ridership stimulus policies around the most responsive user classes.

  7. Identification of developmentally regulated PCP-responsive non-coding RNA, prt6, in the rat thalamus.

    Directory of Open Access Journals (Sweden)

    Hironao Takebayashi

    Full Text Available Schizophrenia and similar psychoses induced by NMDA-type glutamate receptor antagonists, such as phencyclidine (PCP and ketamine, usually develop after adolescence. Moreover, adult-type behavioral disturbance following NMDA receptor antagonist application in rodents is observed after a critical period at around 3 postnatal weeks. These observations suggest that the schizophrenic symptoms caused by and psychotomimetic effects of NMDA antagonists require the maturation of certain brain neuron circuits and molecular networks, which differentially respond to NMDA receptor antagonists across adolescence and the critical period. From this viewpoint, we have identified a novel developmentally regulated phencyclidine-responsive transcript from the rat thalamus, designated as prt6, as a candidate molecule involved in the above schizophrenia-related systems using a DNA microarray technique. The transcript is a non-coding RNA that includes sequences of at least two microRNAs, miR132 and miR212, and is expressed strongly in the brain and testis, with trace or non-detectable levels in the spleen, heart, liver, kidney, lung and skeletal muscle, as revealed by Northern blot analysis. The systemic administration of PCP (7.5 mg/kg, subcutaneously (s.c. significantly elevated the expression of prt6 mRNA in the thalamus at postnatal days (PD 32 and 50, but not at PD 8, 13, 20, or 24 as compared to saline-treated controls. At PD 50, another NMDA receptor antagonist, dizocilpine (0.5 mg/kg, s.c., and a schizophrenomimetic dopamine agonist, methamphetamine (4.8 mg/kg, s.c., mimicked a significant increase in the levels of thalamic prt6 mRNAs, while a D2 dopmamine receptor antagonist, haloperidol, partly inhibited the increasing influence of PCP on thalamic prt6 expression without its own effects. These data indicate that prt6 may be involved in the pathophysiology of the onset of drug-induced schizophrenia-like symptoms and schizophrenia through the possible

  8. El PRT-ERP y la lucha por la libertad de los presos políticos: 1971-1973

    OpenAIRE

    Eidelman, Ariel

    2009-01-01

    Este trabajo aborda la represión política de la militancia revolucionaria por parte del régimen militar y la problemática de los presos políticos en la etapa 1971-1973 en Argentina. Se realiza un análisis de las principales características de la legislación represiva. Centralmente refiere a las diferentes iniciativas desarrolladas por el PRT-ERP en relación con sus militantes presos y en particular a la constitución de una Comisión de familiares de presos políticos, estudiantiles y gremiales ...

  9. Vibrio cholerae cytolysin causes an inflammatory response in human intestinal epithelial cells that is modulated by the PrtV protease.

    Directory of Open Access Journals (Sweden)

    Gangwei Ou

    Full Text Available BACKGROUND: Vibrio cholerae is the causal intestinal pathogen of the diarrheal disease cholera. It secretes the protease PrtV, which protects the bacterium from invertebrate predators but reduces the ability of Vibrio-secreted factor(s to induce interleukin-8 (IL-8 production by human intestinal epithelial cells. The aim was to identify the secreted component(s of V. cholerae that induces an epithelial inflammatory response and to define whether it is a substrate for PrtV. METHODOLOGY/PRINCIPAL FINDINGS: Culture supernatants of wild type V. cholerae O1 strain C6706, its derivatives and pure V. cholerae cytolysin (VCC were analyzed for the capacity to induce changes in cytokine mRNA expression levels, IL-8 and tumor necrosis factor-alpha (TNF-alpha secretion, permeability and cell viability when added to the apical side of polarized tight monolayer T84 cells used as an in vitro model for human intestinal epithelium. Culture supernatants were also analyzed for hemolytic activity and for the presence of PrtV and VCC by immunoblot analysis. CONCLUSIONS/SIGNIFICANCE: We suggest that VCC is capable of causing an inflammatory response characterized by increased permeability and production of IL-8 and TNF-alpha in tight monolayers. Pure VCC at a concentration of 160 ng/ml caused an inflammatory response that reached the magnitude of that caused by Vibrio-secreted factors, while higher concentrations caused epithelial cell death. The inflammatory response was totally abolished by treatment with PrtV. The findings suggest that low doses of VCC initiate a local immune defense reaction while high doses lead to intestinal epithelial lesions. Furthermore, VCC is indeed a substrate for PrtV and PrtV seems to execute an environment-dependent modulation of the activity of VCC that may be the cause of V. cholerae reactogenicity.

  10. The Self-Perception and Relationships Tool (S-PRT: A novel approach to the measurement of subjective health-related quality of life

    Directory of Open Access Journals (Sweden)

    Wishart Paul M

    2004-07-01

    Full Text Available Abstract Background The Self-Perception and Relationships Tool (S-PRT is intended to be a clinically responsive and holistic assessment of patients' experience of illness and subjective Health Related Quality of Life (HRQL. Methods A diversity of patients were involved in two phases of this study. Patient samples included individuals involved with renal, cardiology, psychiatric, cancer, chronic pelvic pain, and sleep services. In Phase I, five patient focus groups generated 128 perceptual rating scales. These scales described important characteristics of illness-related experience within six life domains (i.e., Physical, Mental-Emotional, Interpersonal Receptiveness, Interpersonal Contribution, Transpersonal Receptiveness and Transpersonal Orientation. Item reduction was accomplished using Importance Q-sort and Importance Checklist methodologies with 150 patients across the participating services. In Phase II, a refined item pool (88 items was administered along with measures of health status (SF-36 and spiritual beliefs (Spiritual Involvements and Beliefs Scale – SIBS to 160 patients, of these 136 patients returned complete response sets. Results Factor analysis of S-PRT results produced a surprisingly clean five-factor solution (Eigen values> 2.0 explaining 73.5% of the pooled variance. Items with weaker or split loadings were removed leaving 36 items to form the final S-PRT rating scales; Intrapersonal Well-being (physical, mental & emotional items, Interpersonal Receptivity, Interpersonal Contribution, Transpersonal Receptivity and Transpersonal Orientation (Eigen values> 5.4 explaining 83.5% of the pooled variance. The internal consistency (Cronbach's Alpha of these scales was very high (0.82–0.97. Good convergent correlations (0.40 to 0.67 were observed between the S-PRT scales and the Mental Health scales of the SF-36. Correlations between the S-PRT Intrapersonal Well-being scale and three of SF-36 Physical Health scales were moderate

  11. El PRT-La Verdad entre los trabajadores de la carne de Berisso: La agrupación El Activista de la Carne y la Lista Gris [1967-1972

    Directory of Open Access Journals (Sweden)

    Christian Carlos Hernán Castillo

    2011-10-01

    Full Text Available This article is part of a research about the working class and students struggles and the strategies of the left parties in La Plata city and Gran La Plata between 1966 and 1973. This work is focused on the study of the political activity of the PRT-La Verdad during this period. At the beginning of 1968 the Partido Revolucionario de los Trabajadores -PRT split in two fractions. The fraction led by Nahuel Moreno -named PRT-La Verdad [PRT- The Truth]- was the largest of the two in La Plata y Gran La Plata. In this area the PRT had many members among the students and in the workers movement. This article studies the political activity of the PRT, and the PRT-LV after the split- in the Sindicato de Obreros y Empleados de la Industria de la Carne y Afines de Berisso [Meat Processing Plants Workers Union], between 1967 and 1972 at the Swift and Armour meat processing plants. During the period analyzed in the article, the members and supporters of the PRT-LV were organized in a rank and file union group named El Activista de la Carne - Lista Gris [The Activist-Gray List]. The sources of this research are the bulletins and leaflets edited by El Activista de la Carne. We also consulted the files of DIPBA as well as the bibliography on the subject

  12. Study of CD69 antigen expression and integrity of leukocyte cellular membrane in stored platelet concentrates following irradiation and treatment with Mirasol® PRT System.

    Science.gov (United States)

    Lachert, Elżbieta; Woźniak, Jolanta; Antoniewicz-Papis, Jolanta; Krzywdzińska, Agnieszka; Kubis, Jolanta; Mikołowska, Agata; Letowska, Magdalena

    2017-01-01

    Leukocytes in transfused blood components, particularly residual lymphocytes, have been shown to contribute to the occurrence of various adverse reactions. One of the most severe is transfusionassociated graft versus host disease (TA-GvHD) following transfusion of blood components contaminated with immunocompetent T lymphocytes. Irradiation is a routine method for protection against TA-GvHD. According to the literature, some pathogen reduction methods have also been proven effective for the inactivation of T lymphocytes, and so they may be considered as an alternative to irradiation. Comparison of CD69 antigen expression and the integrity of the leukocyte cellular membrane in stored platelet concentrates (PCs) following irradiation with the Gammacell 3000 Elan (Nordion Inc., Ottawa, Canada) and treatment with the Mirasol® Pathogen Reduction Technology (PRT) System (Terumo BCT, Lakewood, USA). The study included seven experiments. For each experiment we used 3 PCs, for Mirasol® PRT System treatment (M), for Gammacell 3000 Elan irradiation (R), and for the control (C). 7-amino-actinomycin D (7-AAD, Becton Dickinson, Franklin Lakes, USA) permeability was used to determine lymphocyte viability while CD69 antigen expression was the marker of lymphocyte activation. Analyses of 7-AAD and CD69 antigen expression were performed in a FACS Canto I flow cytometer (Becton Dickinson, USA). During 6 storage days, viable lymphocyte count decreased to 28% (p = 0.001) in the Mirasol® PRT System treated PCs and to 65% (p = 0.004) in the irradiated PCs. A statistically significant increase in CD69 expression in the irradiated PCs was observed; 1.3-fold on day 3 and 1.5-fold on day 6. In the Mirasol ® PRT System treated PCs, no statistically significant increase was observed. The in vitro results suggest that the Mirasol® PRT System is as effective as irradiation due to donor leukocyte inactivation capacity.

  13. Mutagenic effect of radionuclides incorporated into DNA of Drosophila melanogaster. Progress report, 1975--1976

    International Nuclear Information System (INIS)

    Lee, W.R.

    1976-01-01

    Progress is reported on research in the following areas: determination of mutagenic effects of tritium incorporated into DNA using 32 P, 33 P, and 14 C; dosimetry studies using number of disintegrations per minute per sperm cell; effect of the 5-position of the label of the cytosine moiety on mutation frequency; distribution of labeled thymine and comparison with labeled cytosine and a non-DNA labeled arginine-rich protein; detection of temperature sensitive mutants; induction of mosaics by x radiation; and methods for determining quantitatively the location of tritium in the deoxycytidine moiety

  14. The Use of Minimum Objectives in Curriculum Research and Development, 1975-1976. Technical Report #45.

    Science.gov (United States)

    Crowell, Doris

    This report describes a curriculum, based on stated performance objectives, which was developed and implemented by the Kamehameha Early Education Program (KEEP). The structure of the mathematics and reading curriculum is described briefly and the use of performance objectives in evaluating student progress is discussed. Advantages of the…

  15. Research program in elementary particle theory. Progress report, 1975--1976

    International Nuclear Information System (INIS)

    Sudarshan, E.C.G.; Ne'eman, Y.

    1976-01-01

    Research on particle theory is summarized including field theory models, phenomenological applications of field theory, strong interactions, the algebraic approach to weak and electromagnetic interactions, and superdense matter. A list of reports is also included

  16. Research program in elementary particle theory. Progress report, 1975--1976. [Summaries of research activities

    Energy Technology Data Exchange (ETDEWEB)

    Sudarshan, E.C.G.; Ne' eman, Y.

    1976-01-01

    Research on particle theory is summarized including field theory models, phenomenological applications of field theory, strong interactions, the algebraic approach to weak and electromagnetic interactions, and superdense matter. A list of reports is also included. (JFP)

  17. Enewetak Radioecology Research Program. I. Ecological studies on Engebi Island, 1975--1976

    International Nuclear Information System (INIS)

    Koranda, J.J.; Robison, W.; Thompson, S.E.; Stuart, M.L.

    1978-01-01

    As part of the Lawrence Livermore Laboratory Enewetak Radioecology Research Program, we studied radionuclide cycling from soil to plant to soil on Engebi Island at the Enewetak Atoll. Mature and dying leaves, young and old litter, humus, and soil beneath these organic strata were collected from 1975-76 at three Engebi sites. To study radionuclide depth distributions, five trenches of > 1 m were dug and sampled. From three representative sites, we found that 137 Cs rapidly cycles from the plant biomass through the litter and humus into the vegetation. Continuously deposited litter decomposes within 6 to 12 months, but the constituent radionuclides are released early during physical decomposition. Soil radionuclides generally occur in the upper 40 cm of the soil profile, strongly associated with the organic horizon. Radionuclides such as 60 Co, 152-155 Eu, 207 Bi, and 241 Am are complexed in the finely divided organic matter or humus where 137 Cs and 40 K predominate. Our data suggest that there is a circulating pool of rapidly cycling 137 Cs in the Engebi ecosystem that may be entirely associated with the plant biomass and organic strata of the soil. Soilbound radionuclides below the humus are low in concentration and may not enter into this pool because they are below the vegetation root zone, where they may be leached by rainwater. This information is needed in making realistic long-term radionuclide dose assessments for the Enewetak peoples

  18. Annual report of reactor management section for fiscal year 1975 - 1976

    International Nuclear Information System (INIS)

    Major activities and events concerning YAYOI (a fast neutron source reactor at the Nuclear Engineering Research Laboratory of the University of Tokyo) during fiscal 1975 and 1976 are summarized. In this period, the reactivity-pulse-operation of the reactor was approved and started. This report presents all efforts for obtaining the license and preliminary performance tests. Major events during this period are weekly recorded and tabulated in a list. Major items included in this report are; details of major events, list of documentation prepared for licensing, revision of safety prescription, submission of preliminary inspections, the history of the reactor operation, and the detail of the expences. (Aoki, K.)

  19. LMFBR safety. 5. Review of current issues and bibliography of literature (1975--1976)

    International Nuclear Information System (INIS)

    Buchanan, J.R.; Keilholtz, G.W.

    1977-01-01

    The current status of liquid-metal fast breeder reactor (LMFBR) development and one of the principal safety issues, a hypothetical core-disruptive accident (HCDA), are discussed. Bibliographic information on worldwide LMFBRs relative to the development and safety of the breeder reactor is presented for the period 1975 through 1976. The bibliography consists of approximately 1618 abstracts covering early research and development and operating experiences leading up to the present design practices that are necessary for the licensing of breeder reactors. Keyword, author, and permuted-title indexes are included for completeness

  20. Phylogeny and sequence variability of the Sarcocystis singaporensis Zaman and Colley, (1975) 1976 ssrDNA

    Czech Academy of Sciences Publication Activity Database

    Šlapeta, Jan Roger; Kyselová, Iveta; Richardson, A. O.; Modrý, David; Lukeš, Julius

    2002-01-01

    Roč. 88, č. 9 (2002), s. 810-815 ISSN 0932-0113 R&D Projects: GA ČR GA524/00/P015; GA AV ČR KSK6005114 Institutional research plan: CEZ:AV0Z6022909 Keywords : Sarcocystis * phylogeny * ssrDNA Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine Impact factor: 1.046, year: 2002

  1. Worldwide photometry and lightcurve observations of 16 Psyche during the 1975-1976 apparition

    Science.gov (United States)

    Tedesco, E. F.; Taylor, R. C.; Drummond, J.; Harwood, D.; Nickoloff, I.; Scaltriti, F.; Zappala, V.

    1983-01-01

    Twenty-six lightcurves of Psyche are presented together with UBV photometry and phase functions from 1975 and 1976. Combining photometric data from this opposition with those from previous apparitions resulted in a mean phase coefficient in V of 0.026 + or - 0.002 mag/deg. No significant phase-dependent variation in the U-B color could be determined from the data; the B-V color, however, displayed a reddening with phase of 0.0010 + or - 0.0004 mag/deg. It is concluded that compositional variations over Psyche's surface are minor, and that Psyche's opposition effect is typical of that for other well-observed asteroids. Psyche's behavior is accounted for if, to the first order, its shape is that of a triaxial ellipsoid with axial ratios near 5:4:3.

  2. Worldwide photometry and lightcurve observations of 16 Psyche during the 1975-1976 apparition

    International Nuclear Information System (INIS)

    Tedesco, E.F.; Taylor, R.C.; Drummond, J.; Harwood, D.; Nickoloff, I.

    1983-01-01

    Twenty-six lightcurves of Psyche are presented together with UBV photometry and phase functions from 1975 and 1976. Combining photometric data from this opposition with those from previous apparitions resulted in a mean phase coefficient in V of 0.026 + or - 0.002 mag/deg. No significant phase-dependent variation in the U-B color could be determined from the data. The B-V color, however, displayed a reddening with phase of 0.0010 + or - 0.0004 mag/deg. It is concluded that compositional variations over Psyche's surface are minor, and that Psyche's opposition effect is typical of that for other well-observed asteroids. Psyche's behavior is accounted for if, to the first order, its shape is that of a triaxial ellipsoid with axial ratios near 5:4:3

  3. Biogeochemistry of radionuclides in aquatic environments. Annual progress report, 1975--1976

    International Nuclear Information System (INIS)

    Schell, W.R.

    1976-01-01

    The present work is a combination of studies on natural radionuclides 210 Po and 210 Pb in aquatic environments and on the biogeochemistry of the transuranium elements 239 Pu, 240 Pu, and 241 Am, in the Bikini Lagoon. The objectives of the biogeochemical studies are to evaluate the cycling of the radionuclides in the aquatic environment from their sources, their distribution within ecosystems, their uptake by biota, and their sinks. Detailed studies of the conditions which now exist some 17 years since the last nuclear detonations at Bikini should give a basis for predicting the effects of large-scale or low-level continuous releases of nuclear waste products in the marine environment

  4. Prime Contract Awards by Service Category and Federal Supply Classification, Fiscal Years 1973, 1974, 1975, 1976.

    Science.gov (United States)

    1976-11-09

    most of the steel plate for ships is purchased by Defense prime contractors, and only a small portion is obtained by direct DoD purchase (see Code 9515...7.14S 9,0St U29 TRAINING OF GOVT PERSONNEL OTHER THAN U621-UG26 26, h13 4.7,63S 215,165 61,603 ’ TOTAL 86,092 116,316 333,121 145,039 V4...S5 M4AFID TOOLS 2.566 4,696 4,SS6 11,206 S2 EASURING TOOLS 1,46S LS6L 1,S94 16 a3 S3 MARONARE AND ABRASIVES 2 364Y 37,967 4.534 o.26 6 54

  5. LMFBR safety. 5. Review of current issues and bibliography of literature (1975--1976)

    Energy Technology Data Exchange (ETDEWEB)

    Buchanan, J.R.; Keilholtz, G.W.

    1977-06-08

    The current status of liquid-metal fast breeder reactor (LMFBR) development and one of the principal safety issues, a hypothetical core-disruptive accident (HCDA), are discussed. Bibliographic information on worldwide LMFBRs relative to the development and safety of the breeder reactor is presented for the period 1975 through 1976. The bibliography consists of approximately 1618 abstracts covering early research and development and operating experiences leading up to the present design practices that are necessary for the licensing of breeder reactors. Keyword, author, and permuted-title indexes are included for completeness.

  6. Population Transplant From Adana After Peace Operations Carried Out In Cyprus (1975-1976

    Directory of Open Access Journals (Sweden)

    Erdem ÇANAK

    2015-12-01

    Full Text Available Ottoman Empire ruled Cyprus between the years 1571-1878, in 1878 with Treaty of Lausanne was officially passed to England temporarily. Greeks who want to take advantage of this situation, gave fresh impetus to activities for“Enosis” . This process which led to the struggle for existence of Turks in the island and has resulted Peace Operation in 1974. However, Turks emigrated to different parts of the world, mainly toTurkey due to the pressure that they are exposed in the period leading up to the Peace Operation. Therefore, after the operation, Turkish control of the labor needed to eliminate the deficit for the processing of the soil and the new government in order to ensure the economic development of the population of Turkey was carried transplant candidates. “Agricultural labor” the province’s population transfer carried out of Adana. In this regard all farmers from Adana, 1.480 men in 531 households, 1.287’s including women 2.767 people were resettled on the island. In this study, after the operation settlement the process with the transplant population of immigrants from Adana has been discussed.

  7. Population Transplant From Adana After Peace Operations Carried Out In Cyprus (1975-1976)

    OpenAIRE

    Erdem ÇANAK

    2015-01-01

    Ottoman Empire ruled Cyprus between the years 1571-1878, in 1878 with Treaty of Lausanne was officially passed to England temporarily. Greeks who want to take advantage of this situation, gave fresh impetus to activities for“Enosis” . This process which led to the struggle for existence of Turks in the island and has resulted Peace Operation in 1974. However, Turks emigrated to different parts of the world, mainly toTurkey due to the pressure that they are exposed in the period leading up to ...

  8. Solid state chemistry of rare earth oxides. Technical progress report, 1975--1976

    International Nuclear Information System (INIS)

    Eyring, L.; Skarnulis, A.J.; Tuenge, R.T.; Von Dreele, R.B.

    1976-01-01

    It has been demonstrated that electron microscope images obtained at about 3A resolution for Pr 7 O 12 are in agreement with calculated images based upon known structures. This establishes the efficacy of crystal structure image interpretation in structural terms, including the defect structure and mechanism of phase reactions, for these types of related phases whose structures are as yet beyond conventional means to determine. Further work on the epsilon (Pr 10 O 18 ) phase is reported both utilizing electron optical methods and single crystal X-ray techniques. The ternary ceramic system HfO 2 .xEr 2 O 3 is being examined using electron optical techniques and ordering not hitherto reported is being observed. An interactive crystal structure image calculation system is being developed which will permit the immediate comparison of enhanced images synthesized from trial structures (including defects) and displayed in juxtaposition on a graphics unit. 22 fig

  9. Biofilm Formation on Stainless Steel by Streptococcus thermophilus UC8547 in Milk Environments Is Mediated by the Proteinase PrtS.

    Science.gov (United States)

    Bassi, D; Cappa, F; Gazzola, S; Orrù, L; Cocconcelli, P S

    2017-04-15

    In Streptococcus thermophilus , gene transfer events and loss of ancestral traits over the years contribute to its high level of adaptation to milk environments. Biofilm formation capacity, a phenotype that is lost in the majority of strains, plays a role in persistence in dairy environments, such as milk pasteurization and cheese manufacturing plants. To investigate this property, we have studied S. thermophilus UC8547, a fast-acidifying dairy starter culture selected for its high capacity to form biofilm on stainless steel under environmental conditions resembling the dairy environment. Using a dynamic flow cell apparatus, it was shown that S. thermophilus UC8547 biofilm formation on stainless steel depends on the presence of milk proteins. From this strain, which harbors the prtS gene for the cell wall protease and shows an aggregative phenotype, spontaneous mutants with impaired biofilm capacity can be isolated at high frequency. These mutants lack the PrtS expendable island, as confirmed by comparison of the genome sequence of UC8547Δ3 with that of the parent strain. The prtS island excision occurs between two 26-bp direct repeats located in the two copies of the IS Sth1 flanking this genomic island. The central role of PrtS was confirmed by analyzing the derivative strain UC8547Δ16, whose prtS gene was interrupted by an insertional mutation, thereby making it incapable of biofilm formation. PrtS, acting as a binding substance between the milk proteins adhered to stainless steel and S. thermophilus cell envelopes, mediates biofilm formation in dairy environments. This feature provides S. thermophilus with an ecological benefit for its survival and persistence in this environment. IMPORTANCE The increased persistence of S. thermophilus biofilm has consequences in the dairy environment: if, on the one hand, the release of this microorganism from biofilm can promote the fermentation of artisanal cheeses, under industrial conditions it may lead to undesirable

  10. A Randomized Clinical Trial Comparison Between Pivotal Response Treatment (PRT) and Adult-Driven Applied Behavior Analysis (ABA) Intervention on Disruptive Behaviors in Public School Children with Autism.

    Science.gov (United States)

    Mohammadzaheri, Fereshteh; Koegel, Lynn Kern; Rezaei, Mohammad; Bakhshi, Enayatolah

    2015-09-01

    Children with autism often demonstrate disruptive behaviors during demanding teaching tasks. Language intervention can be particularly difficult as it involves social and communicative areas, which are challenging for this population. The purpose of this study was to compare two intervention conditions, a naturalistic approach, Pivotal Response Treatment (PRT) with an adult-directed ABA approach on disruptive behavior during language intervention in the public schools. A randomized clinical trial design was used with two groups of children, matched according to age, sex and mean length of utterance. The data showed that the children demonstrated significantly lower levels of disruptive behavior during the PRT condition. The results are discussed with respect to antecedent manipulations that may be helpful in reducing disruptive behavior.

  11. Studies on a novel serine protease of a ΔhapAΔprtV Vibrio cholerae O1 strain and its role in hemorrhagic response in the rabbit ileal loop model.

    Directory of Open Access Journals (Sweden)

    Aurelia Syngkon

    Full Text Available BACKGROUND: Two well-characterized proteases secreted by Vibrio cholerae O1 strains are hemagglutinin protease (HAP and V. cholerae protease (PrtV. The hapA and prtV knock out mutant, V. cholerae O1 strain CHA6.8ΔprtV, still retains residual protease activity. We initiated this study to characterize the protease present in CHA6.8ΔprtV strain and study its role in pathogenesis in rabbit ileal loop model (RIL. METHODOLOGY/PRINCIPAL FINDINGS: We partially purified the residual protease secreted by strain CHA6.8ΔprtV from culture supernatant by anion-exchange chromatography. The major protein band in native PAGE was identified by MS peptide mapping and sequence analysis showed homology with a 59-kDa trypsin-like serine protease encoded by VC1649. The protease activity was partially inhibited by 25 mM PMSF and 10 mM EDTA and completely inhibited by EDTA and PMSF together. RIL assay with culture supernatants of strains C6709 (FA ratio 1.1+/-0.3 n = 3, CHA6.8 (FA ratio 1.08+/-0.2 n = 3, CHA6.8ΔprtV (FA ratio 1.02+/-0.2 n = 3 and partially purified serine protease from CHA6.8ΔprtV (FA ratio 1.2+/-0.3 n = 3 induced fluid accumulation and histopathological studies on rabbit ileum showed destruction of the villus structure with hemorrhage in all layers of the mucosa. RIL assay with culture supernatant of CHA6.8ΔprtVΔVC1649 strain (FA ratio 0.11+/-0.005 n = 3 and with protease incubated with PMSF and EDTA (FA ratio 0.3+/-0.05 n = 3 induced a significantly reduced FA ratio with almost complete normal villus structure. CONCLUSION: Our results show the presence of a novel 59-kDa serine protease in a ΔhapAΔprtV V. cholerae O1 strain and its role in hemorrhagic response in RIL model.

  12. El PRT-La Verdad entre los trabajadores de la carne de Berisso: La agrupación El Activista de la Carne y la Lista Gris (1967-1972)

    OpenAIRE

    Castillo, Christian

    2011-01-01

    Este trabajo se enmarca dentro de un proyecto más general referido al estudio de los conflictos obreros y estudiantiles y las estrategias de la izquierda en La Plata y Gran La Plata entre 1966 y 1973 y, más en particular, del estudio de la actividad en la región durante ese período del PRT-La Verdad. De las dos fracciones en las que se escindió el Partido Revolucionario de los Trabajadores a comienzos de 1968, el sector encabezado por Nahuel Moreno ?que pasó a denominarse "PRT-La Verdad"- fue...

  13. Proton radiation therapy (prt) for pediatric optic pathway gliomas: comparison with 3d planned conventional photons and a standard photon technique

    International Nuclear Information System (INIS)

    Fuss, Martin; Hug, Eugen B.; Schaefer, Rosemary A.; Nevinny-Stickel, Meinhard; Miller, Daniel W.; Slater, James M.; Slater, Jerry D.

    1999-01-01

    Purpose: Following adequate therapy, excellent long-term survival rates can be achieved for patients with optic pathway gliomas. Therefore, avoidance of treatment-related functional long-term sequelae is of utmost importance. Optimized sparing of normal tissue is of primary concern in the development of new treatment modalities. The present study compares proton radiation therapy (PRT) with a three-dimensional (3D)-planned multiport photon and a lateral beam photon technique for localized and extensive optic pathway tumors. Methods and Materials: Between February 1992 and November 1997, seven children with optic pathway gliomas underwent PRT. For this study, we computed proton, 3D photon, and lateral photon plans based on the same CT data sets, and using the same treatment planning software for all plans. Radiation exposure for normal tissue and discrete organs at risk was quantified based on dose-volume histograms. Results: Gross tumor volume (GTV) ranged from 3.9 cm 3 to 127.2 cm 3 . Conformity index (relation of encompassing isodose to GTV volume) was 2.3 for protons, 2.9 for 3D photons, and 7.3 for lateral photons. The relative increase of normal tissue (NT) encompassed at several isodose levels in relation to NT encompassed by the 95% proton isodose volume was computed. Relative NT volume of proton plan isodoses at the 95%, 90%, 80%, 50%, and 25% isodose level increased from 1 to 1.6, 2.8, 6.4, to a maximum of 13.3. Relative volumes for 3D photons were 1.6, 2.4, 3.8, 11.5, and 34.8. Lateral plan relative values were 6, 8.3, 11.5, 19.2, and 26.8. Analysis for small ( 3 ) and larger (> 80 cm 3 ) tumors showed that protons encompassed the smallest volumes of NT at all isodose levels. Comparable conformity and high-dose gradient were achieved for proton and 3D photon plans in small tumors. However, with increasing tumor volume and complexity, differences became larger. At the 50% isodose level, 3D photons were superior to lateral photons for small tumors; this

  14. Contribution of plasmid-encoded peptidase S8 (PrtP) to adhesion and transit in the gut of Lactococcus lactis IBB477 strain.

    Science.gov (United States)

    Radziwill-Bienkowska, Joanna Maria; Robert, Véronique; Drabot, Karolina; Chain, Florian; Cherbuy, Claire; Langella, Philippe; Thomas, Muriel; Bardowski, Jacek Karol; Mercier-Bonin, Muriel; Kowalczyk, Magdalena

    2017-07-01

    The ability of Lactococcus lactis to adhere to the intestinal mucosa can potentially prolong the contact with the host, and therefore favour its persistence in the gut. In the present study, the contribution of plasmid-encoded factors to the adhesive and transit properties of the L. lactis subsp. cremoris IBB477 strain was investigated. Plasmid-cured derivatives as well as deletion mutants were obtained and analysed. Adhesion tests were performed using non-coated polystyrene plates, plates coated with mucin or fibronectin and mucus-secreting HT29-MTX intestinal epithelial cells. The results indicate that two plasmids, pIBB477a and b, are involved in adhesion of the IBB477 strain. One of the genes localised on plasmid pIBB477b (AJ89_14230), which encodes cell wall-associated peptidase S8 (PrtP), mediates adhesion of the IBB477 strain to bare, mucin- and fibronectin-coated polystyrene, as well as to HT29-MTX cells. Interactions between bacteria and mucus secreted by HT29-MTX cells were further investigated by fluorescent staining and confocal microscopy. Confocal images showed that IBB477 forms dense clusters embedded in secreted mucus. Finally, the ability of IBB477 strain and its ΔprtP deletion mutant to colonise the gastrointestinal tract of conventional C57Bl/6 mice was determined. Both strains were present in the gut for up to 72 h. In summary, adhesion and persistence of IBB477 were analysed by in vitro and in vivo approaches, respectively. Our studies revealed that plasmidic genes encoding cell surface proteins are more involved in the adhesion of IBB477 strain than in the ability to confer a selective advantage in the gut.

  15. La Participación Empresarial en la Conspiración Golpista en Argentina (1975-1976

    Directory of Open Access Journals (Sweden)

    Gonzalo Sanz Cerbino

    2016-03-01

    Full Text Available RESUMEN El golpe de Estado consumado en la Argentina en 1976 fue el resultado de una extensa conspiración que involucró a importantes fracciones de la burguesía local. Este artículo pretende echar luz sobre el problema, poco estudiado por las ciencias sociales, reconstruyendo la ofensiva golpista que se inicia en 1975. Tras analizar en detalle los posicionamientos públicos, las acciones de protesta y los vínculos políticos de distintos agrupamientos y corporaciones empresariales con los militares, el texto demuestra que las Fuerzas Armadas no actuaron por su cuenta al perpetrar el golpe, sino que fueron el instrumento de una amplia alianza social conformada para tal fin.

  16. Temel Tepki Öğretimi-TTÖ (Pivotal Response Treatment-PRT İle Gerçekleştirilen Etkililik Araştırmalarının Betimsel Analizi

    Directory of Open Access Journals (Sweden)

    Özlem TOPER-KORKMAZ

    2013-01-01

    Full Text Available Temel Tepki Öğretimi (TTÖ Amerika Ulusal Otizm Merkezi (NAC, 2009 tarafından yayınlanmış olan Ulusal Standartlar Raporun’da otizmli çocukların eğitimde kullanılan bilimsel dayanaklı uygulamalardan bir tanesi olarak kabul edilmektedir. TTÖ hem uygulamalı davranış analizi ilkelerine dayanan hem de doğal bir öğretim yöntemidir. Yöntem öğrenci merkezli ve aile eğitimi esaslı olup çocuklara belli temel davranışları kazandırmayı ve buna bağlı olarakta hedeflenmeyen başka alanlarda da ilerlemeler sağlanacağını savunur. Bu çalışmada TTÖ’ne yönelik bir alan yazın çalışması amaçlanmış ve bu amaçla 1995 ile 2011 yılları arasında TTÖ ile gerçekleştirilmiş olan 16 etkililik araştırmasına ulaşılarak bu araştımalar betimsel olarak analiz edilmiştir. Elde edilen bulgular TTÖ’nün okul öncesi ve ilköğretim dönemindeki otizm spektrum bozukluğu gösteren çocuklara ifade edici dil becerilerinin kazandırılmasında, sosyal becerilerin ve oyun becerilerinin öğretiminde etkili olduğunu göstermektedir Pivotal Response Treatment (PRT is one of evidence based treatments identified in the US National Autism Center's National Standards Report published in 2009. PRT is a comprehensive instructional model based on developmental approach and applied behavior analysis principles to provide learning opportunities for supporting children in their natural environments. PRT is a student-centered and parent-training based procedure and advocates that if children achieve some pivotal behaviors, it provides positive effects on untargeted behaviors and also if these pivotal behaviors are achieved once, results will be common and generalizable. The purpose of this study is, by using descriptive analysis, to review the sixteen effectiveness studies of PRT published in 1995-2011. Results of review showed that PRT is an effective procedure on language skills, social skills and play skills of preschool and

  17. Pathogen inactivation efficacy of Mirasol PRT System and Intercept Blood System for non-leucoreduced platelet-rich plasma-derived platelets suspended in plasma.

    Science.gov (United States)

    Kwon, S Y; Kim, I S; Bae, J E; Kang, J W; Cho, Y J; Cho, N S; Lee, S W

    2014-10-01

    This study was conducted to evaluate the efficacy of pathogen inactivation (PI) in non-leucoreduced platelet-rich plasma-derived platelets suspended in plasma using the Mirasol PRT System and the Intercept Blood System. Platelets were pooled using the Acrodose PL system and separated into two aliquots for Mirasol and Intercept treatment. Four replicates of each viral strain were used for the evaluation. For bacteria, both low-titre (45-152 CFU/unit) inoculation and high-titre (7·34-10·18 log CFU/unit) inoculation with two replicates for each bacterial strain were used. Platelets with non-detectable bacterial growth and platelets inoculated with a low titre were stored for 5 days, and culture was performed with the BacT/ALERT system. The inactivation efficacy expressed as log reduction for Mirasol and Intercept systems for viruses was as follows: human immunodeficiency virus 1, ≥4·19 vs. ≥4·23; bovine viral diarrhoea virus, 1·83 vs. ≥6·03; pseudorabies virus, 2·73 vs. ≥5·20; hepatitis A virus, 0·62 vs. 0·76; and porcine parvovirus, 0·28 vs. 0·38. The inactivation efficacy for bacteria was as follows: Escherichia coli, 5·45 vs. ≥9·22; Staphylococcus aureus, 4·26 vs. ≥10·11; and Bacillus subtilis, 5·09 vs. ≥7·74. Postinactivation bacterial growth in platelets inoculated with a low titre of S. aureus or B. subtilis was detected only with Mirasol. Pathogen inactivation efficacy of Intercept for enveloped viruses was found to be satisfactory. Mirasol showed satisfactory inactivation efficacy for HIV-1 only. The two selected non-enveloped viruses were not inactivated by both systems. Inactivation efficacy of Intercept was more robust for all bacteria tested at high or low titres. © 2014 International Society of Blood Transfusion.

  18. Integration of Staff Development and Research: Description of the Staff Development Project in Progress for the School Year 1975-1976. Technical Report #62.

    Science.gov (United States)

    Speidel, Gisela E.

    This report from the Kamehameha Early Education Program (KEEP) describes the 1975-76 KEEP staff development program, which was designed to integrate staff development and research. Specific purposes of the program were: (1) to develop the abilities of the teaching staff in teaching, consultation, and research; (2) to conduct pilot research in…

  19. Plutonium and americum concentration along fresh water food chains of the Great Lakes, U.S.A. General summary of progress, 1975--1976

    International Nuclear Information System (INIS)

    Bowen, V.T.

    1976-01-01

    Progress is reported for studies on the distribution of long-lived transuranic nuclides and 137 Cs introduced into the Great Lakes by fallout deposits or in radioactive effluents from nuclear facilities. Emphasis is placed on the content of 137 Cs, 241 Am, 239 Pu, 240 Pu, and 244 Cm in plankton, fish, and sediments sampled in Lake Erie and Lake Ontario during 1975 and 1976

  20. Ecological study of the effects of power plants on benthic macroplant microcosms in subtropical and tropical estuaries. Annual progress report, 1975--1976

    International Nuclear Information System (INIS)

    Thorhaug, A.

    1976-05-01

    The major focus was to understand the function of the seagrass community and to relate this to the impact of energy related activities, most importantly, thermal effluent. In addition, the increased turbidity, current, siltation and heavy metals were factors at the Turkey Point site. We attempted to delineate the effect of heat in the laboratory to determine the upper thermal tolerance of the seagrass. This was shown to be quite close to the combined effect of all the pollutants in the field for Thalassia and the macroalgae. This would indicate that temperature is a very fundamental factor in the growth and survival of the seagrass community

  1. Arctic Ice Dynamics Joint Experiment 1975-1976. Physical Oceanography Data Report, Salinity, Temperature and Depth Data, Camp Big Bear. Volume IV.

    Science.gov (United States)

    1980-02-01

    C to~~~ II qo 3 4 .. ..N~ V. ...... .V . .N N . .S ... .V .fI . i 0 Wi . .... . 53 .O .00... 0--N. .. ZZ W. I -. 0 -z J~~D &Z av F - -q qWe at s-a...q .a1 2c z oft ew dw- lp- eE- W - 0- fP- M .. 1 ,1e mc VftWU 00, 0%0 0000 - P-PtftoO. -%ffE Uqvv 4i . qwE ft . 04W -f ewF-0 wa rnm~~t.- tol Uw0 f E0

  2. Arctic Ice Dynamics Joint Experiment (AIDJEX) 1975-1976, Physical Oceanography Data Report Profiling Current Meter Data -- Camp Caribou. Volume 1.

    Science.gov (United States)

    1980-02-01

    base of the ice. Hourly averages pertaining to the fixed-mast current meters can be obtained through the National Oceano - graphic Data Center. The...431 441 451 461 471 481 49t 50 40 ’II 421 431 441 󈧷j 461 4󈨋 481 491 Sol , 71ME :N :AYs Fig’ure 11. Speed and direction plotted for the manned AIDJEX...EDDIES Swift mesoscale undercurrents are one of the most notable oceano - graphic features observed in the AIDJEX area of the Arctic Ocean. The eddy form

  3. Arctic Ice Dynamics Joint Experiment 1975-1976. Physical Oceanography Data Report, Salinity, Temperature and Depth Data, Camp Caribou. Volume I.

    Science.gov (United States)

    1980-02-01

    0 wr NM 1 NNNN .VIDT00m 00~ V"!8% 00 WVm Mmp 08NN M8MM f"i M0 Ott " -n-nn ON & MM 84. 0’IM-0 Ic 5-0 0 . .8. . ....... .. o noemn l I.50n MM MM.f m.MN...0 .4-O"s- W oo P Sn .0o %.in-0 06"l 00l-o 0--P- s-fp.P ?o’ 0-0~- .. Me5U MM5i MW We M Pa- 0* PIM - .4 ൈM" IMts...8217 It T- Ott , Tq 5 :Tn.a- 0 a11-0 T .:C UW-0- C t LJ34 0 -M N MM ~ ~ lM 44 Irvf: 555. 55?? o0 02 :t!:: 4 ljWOWU"M, n HO I 1010. . X 000..4~Iin00.0. 50

  4. Arctic Ice Dynamics Joint Experiment 1975-1976. Physical Oceanography Data Report, Salinity, Temperature and Depth Data, Camp Blue Fox. Volume II.

    Science.gov (United States)

    1980-02-01

    their place within the chart system (even to the width of the ink line) the failings of the human hand and the subjective judgements made tend to...I.no OArw Wn 0 00 CC%04"n00000000000&IM ~000 0000000 00 000000 CMe IN MN INI16 er6 111 1 c-I NN Mm CVMMC "NwtedC Ivr~ IVC MIN Ilf e" Ivf I~c I4,MN Mr Mr...DECL ASSI FI C ATI ON/DOWN GRADING SCHEDULE IS. DISTRIBUTION STATEMENT (of tli Report) Approved for public release; distribution unlimited. Reproduction

  5. NODC Standard Format Marine Mammals of Coastal Alaska Data (1975-1976): Marine Mammal Sighting 2 (F026) (NODC Accession 0014151)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC maintains data in three NODC Standard Format Marine Mammal Data Sets: Marine Mammal Sighting and Census (F127); Marine Mammal Specimens (F025); Marine Mammal...

  6. Results of environmental radioactivity measurements in the member states of the European Community for air, deposition, water, milk, 1975-1976

    International Nuclear Information System (INIS)

    1978-01-01

    The present document is the sixteenth report published by the Health and Safety Directorate of the Commission of the European Communities concerning ambient radioactivity. It was drawn up using the data collected by the stations in charge of the surveillance of environmental radioactivity in the Member States. The results are extracts from the data sent to the Commission in application of Article 36 of the Treaty of Rome instituting the European Atomic Energy Community. This is the second document which includes data from the enlarged community-viz. Belgium, the Federal Republic of Germany, France, Italy, Luxembourg, the Netherlands, plus Denmark, Ireland and the United Kingdom, who joined the Community on 1 January 1973. The results presented in this report deal with radioactive contamination of the air, precipitaton and fallout, surface water and milk during 1975 and 1976

  7. Managing Transit Ridership with Short-Term Economic Incentives

    Science.gov (United States)

    1982-08-01

    It is the purpose of this booklet to give the reader an overview of the variety, : type, and nature of short-term economic incentive programs that have been : introduced by transit properties over the past few years. 3054k, 55p.

  8. Ridership impacts of South Florida's EASY smart card : [summary].

    Science.gov (United States)

    2013-07-01

    Transit agencies across the U.S. increasingly are replacing electronic fare reading systems with Advanced Fare Collection (AFC) or smart card systems. In 2009, Miami-Dade Transit (MDT) was the first Florida transit agency to deploy AFC, branded...

  9. Real-time subway information for improving transit ridership.

    Science.gov (United States)

    2016-08-01

    In recent years, the standardization of transit schedule information has yielded a dramatic increase in the accessibility of computerized transit schedules and given rise to real-time service schedules. Two such real-time service schedules are the Ge...

  10. Barış Harekâtı Sonrasında Adana’dan Kıbrıs’a Gerçekleştirilen Nüfus Nakli (1975-1976)

    OpenAIRE

    ÇANAK, Erdem

    2015-01-01

    1571-1878 yılları arasında Osmanlı Devleti’nin hâkimiyeti altında bulunan Kıbrıs, 1878 yılında geçici olarak, Lozan Antlaşması ile de resmen İngiltere’ye geçmiştir. Bu durumdan faydalanmak isteyen Rumlar da “Enosis”e yönelik faaliyetlerine hız vermişlerdir. Adadaki Türklerin var olma mücadelesine neden olan bu süreç, 1974 Barış Harekâtı ile neticelenmiştir. Ancak Türkler, Barış Harekâtı’na kadar olan dönemde maruz kaldıkları baskıdan dolayı zaman zaman başta Türkiye olmak üzere dünyanın farkl...

  11. Etude de l'influence des produits de traitement de la vigne sur la microflore des raisins et des vins. Expérimentation 1978-1979. Comparaison avec les résultats de 1975, 1976 et 1977

    Directory of Open Access Journals (Sweden)

    Simone Sapis-domercq

    1980-09-01

    Following preceding work about microflora identification of pesticides treated grapes, the influence of some of these products (especially anti-mildiou and anti-Botrytis on usual types of yeasts and bacteria involved in wine technology was studied. Hanseniaspora uvarum, Saccharomyces cerevisiae, Saccharomyces bayanus are sensitive to Euparène, Cuprosan and Mycodifol. Lactic and acetic bacteria are less sensitive. Howewer, the highest resistant yeasts have not an alcoholic power sufficient to achieve the fermentation of the sugar up to complete consumption.

  12. Estudo comparativo da pressão arterial e da prevalência de hipertensão arterial em duas coortes sucessivas (1975-1976 de estudantes de 16 a 25 anos, Botucatu, SP, Brasil Blood pressure levels and hipertension prevalence in 16 to 25 year-old students in Botucatu, S. Paulo, Brazil. A comparative study of two successive cohorts, 1975-1976

    Directory of Open Access Journals (Sweden)

    Dináh Borges de Almeida

    1978-12-01

    Full Text Available Com o objetivo de determinar os níveis de pressão arterial e a prevalência de hipertensão arterial em uma população jovem, foram realizados pesquisas em dois anos sucessivos em 1.288 e 736 estudantes de Botucatu, SP (Brasil tendo sido comparados os resultados obtidos. As médias das pressões sistólicas da população estudada e dos dois grupos etários desta população (16 a 20 anos e 21 a 25 anos foram idênticas em ambos os anos, tendo as médias das pressões diastólicas diferido de no máximo 2 mmHg; as médias, tanto sistólicas quanto diastólicas, dos dois sexos e da parcela branca da população estudada quanto à idade e sexo também diferiram de no máximo 2 mmHg. As médias da população estudada e sua parcela branca, em ambos os anos, foram superiores no sexo masculino e no grupo etário de 21 a 25 anos. Na população negra e amarela houve disparidade de resultados entre 1975 e 1976, indicando influência da exiguidade do tamanho dos contigentes negro e amarelo desta população. A prevalência de hipertensão arterial (pressão sistólica igual ou maior que 140 mmHg e diastólica igual ou maior que 90 mmHg foi de 5,04% em 1975 e 6,22% em 1976, tendo sido em ambos os anos maior no sexo masculino do que no feminino e no grupo de 21 a 25 do que no de 16 a 20 anos.To determine the prevalence of hypertension and blood pressure levels in a young population group, two groups, one of 1288 students and another of 736, all from Botucatu, were investigated during two consecutive years, and the results were then compared. The mean values for systolic readings of the whole population, as for the two age groups (16 to 20 and 21 to 25 years old, were identical for both years studied; the diastolic mean values differed by 2 mmHg at most. The mean systolic and diastolic reading for both sexes and among the whites also differed by 2 mmHg at most. The mean values for the whole population and among the white population were higher for males than for females, and also higher in the 21 to 25 age group than in the 16 to 20 group. The 1975 and 1976 results for the black and yellow population were inconsistent, reflecting the influence of the small size of these groups. The prevalence of arterial hypertension (systolic readings equal to or higher than 140 mmHg and diastolic readings equal to or higher than 90 mmHg was 5.04% in 1975 and 6.22% in 1976, being higher in the males than in the females and higher in the 21 to 25 age group than in the 16 to 20 year-old group.

  13. The PRT Concept -- US Experiences and Their Relevance for Norway

    National Research Council Canada - National Science Library

    Vaagland, Per O

    2008-01-01

    ...) in Afghanistan, and Norway's concept of operations of PRTs in that country. One of the goals of this study is to examine the challenges connected with the establishment of such a concept, which is interagency and civilian-military in nature...

  14. An assessment of transit ridership: increased suburban to urban public transportation options in Houston, Texas.

    Science.gov (United States)

    2008-11-01

    Suburban development is occurring near urban areas across America. Often these communities are : separated by large masses of land with no linkage to the urban core. Referred to as urban sprawl, this type : of development causes a challenge for trans...

  15. Effect of bike lane infrastructure improvements on ridership in one New Orleans neighborhood.

    Science.gov (United States)

    Parker, Kathryn M; Rice, Janet; Gustat, Jeanette; Ruley, Jennifer; Spriggs, Aubrey; Johnson, Carolyn

    2013-02-01

    Incorporating cycling into daily life is one way to increase physical activity. This study examined the impact of building new bike lanes in New Orleans to determine whether more people were cycling on the street and with the flow of traffic after bike lanes were built. Through direct observation of one intervention and two adjacent streets, observers counted cyclists riding on the street and sidewalk, with and against traffic, before and after installation of the lanes. Data were tallied separately for adults, children, males, females, and by race for each location. There was an increase in cyclists on all three streets after the installation of the bike lanes, with the largest increase on the street with the new lane. Additionally, the proportion of riders cycling with traffic increased after the lanes were striped. Bike lanes can have a positive impact in creating a healthy neighborhood.

  16. Short-Term Prediction of Ridership on Public Transport with Smart Card Data

    NARCIS (Netherlands)

    van Oort, N.; Brands, Ties; de Romph, E.

    2015-01-01

    Public transport operators are collecting massive amounts of data from smart card systems. In the Netherlands, every passenger checks in and checks out; this system creates detailed records of demand patterns. In buses and trams, users check in and check out in the vehicle; this factor provides good

  17. Data-driven public transport ridership prediction approach including comfort aspects

    NARCIS (Netherlands)

    Van Oort, N.; Drost, M.; Brands, T.; Yap, M.

    2015-01-01

    The most important aspects on which passengers base their choice whether to travel by public transport are the perceived travel time, costs, reliability and comfort. Despite its importance, comfort is often not explicitly considered when predicting demand for public transport. In this paper, we

  18. Evaluating the Impacts of Real-Time Information on Subway Ridership in New York City

    Science.gov (United States)

    2018-05-21

    It is now common for transit operators to provide real-time information (RTI) to passengers about the location or predicted arrival times of transit vehicles. The Metropolitan Transportation Authority (MTA) in New York City has recently made RTI avai...

  19. The Effects of Bus Ridership on Airborne Particulate Matter (PM10) Concentrations

    OpenAIRE

    Jaeseok Her; Sungjin Park; Jae Seung Lee

    2016-01-01

    Air pollution caused by rapid urbanization and the increased use of private vehicles seriously affects citizens’ health. In order to alleviate air pollution, many cities have replaced diesel buses with compressed natural gas (CNG) buses that emit less exhaust gas. Urban planning strategies such as transit-oriented development (TOD) posit that reducing private vehicle use and increasing public transportation use would reduce air pollution levels. The present study examined the effects of bus r...

  20. Characterization of the Aspergillus niger prtT, a unique regulator of extracellular protease encoding genes

    NARCIS (Netherlands)

    Punt, P.J.; Schuren, F.H.J.; Lehmbeck, J.; Christensen, T.; Hjort, C.; Hondel, C.A.M.J.J. van den

    2008-01-01

    Expression of several Aspergillus niger genes encoding major secreted, but not vacuolar, protease genes including the major acid protease gene pepA, was shown to be affected in the previously isolated A. niger protease mutant, AB1.13 [Mattern, I.E., van Noort, J.M., van den Berg, P., Archer, D.A.,

  1. Application of AE to evaluate deterioration of prt and harbor structures

    International Nuclear Information System (INIS)

    Matsuyama, Kimitoshi; Ishibashi, Akichika; Fujiwara, Tetsuro; Kanemoto, Yasuhiro; Hamada, Shigenori; Ohtsu, Masayasu

    1997-01-01

    The degree of concrete deterioration is normally evaluated by uniaxial compression tests of core samples taken from existing concrete structures. The uniaxial compression test can give details on concrete strength, elastic modulus and so forth. By using AE(acoustic emission) technique with uniaxial compression tests, we can get more useful information on interior failures of the core sample. The observation of AE activity was conducted during uniaxial compression tests of concrete specimens and samples. The specimens were cast with 5, 10, 15 and 20% air content. The samples were taken from 2 harbor sites in Japan. Generating behavior of AE was studied quantitatively on the basis of rate process theory. Distribution of pores in the concrete could be measured by the porosimeter. The relation between AE activity in the uniaxial compression test of core samples and concrete property is clarified.

  2. Pekerja Rumah Tangga (PRT dan penerimaan terhadap makna spiritual dalam tayangan religi di televisi

    Directory of Open Access Journals (Sweden)

    Reny Triwardani

    2014-07-01

    Full Text Available Religious soap opera is a tv shows that display story and culture which related to Islam within its story line. Different representations within religoius soap opera could lead to various interpretations. The text displayed posses dynamic values, particularly about how a text receive a value after being consumed by its audience. This research aims to describe audience acceptance level of spiritual meaning in religion tv shows. TV programs that had been observed were Layar kemilau (MNC TV and sinema Pintu Taubat (Indosiar. This research uses descriptive qualitative method with in depth interview using 3 informants. Stuart Hall acceptance analysis was was used to identify two from three different affeptance models; dominant and negotiating. This research identify dominant and negotiating audience as informant to answer the research question. Informant background, peer group influence, the need of enterainment and audience gender were founded as significant inlfluencer of domestic workers’ decision to watch religion soap opera in TV. This research shows that different interpretation obtained the audience can be reciprocal or contradict with the content of religious soap opera in TV

  3. The Spatial Effect of Socio-Economic Demographics on Transit Ridership: a Case Study in New York

    Science.gov (United States)

    2018-03-01

    Demand for vehicle and public transportation systems continues to increase in and around major urban centers. This increase is especially pronounced during the morning and evening commutes and is further complicated by the complex spatial interaction...

  4. Estimate of Fuel Consumption and GHG Emission Impact on an Automated Mobility District: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yuche; Young, Stanley; Gonder, Jeff; Qi, Xuewei

    2015-12-11

    This study estimates the range of fuel and emissions impact of an automated-vehicle (AV) based transit system that services campus-based developments, termed an automated mobility district (AMD). The study develops a framework to quantify the fuel consumption and greenhouse gas (GHG) emission impacts of a transit system comprised of AVs, taking into consideration average vehicle fleet composition, fuel consumption/GHG emission of vehicles within specific speed bins, and the average occupancy of passenger vehicles and transit vehicles. The framework is exercised using a previous mobility analysis of a personal rapid transit (PRT) system, a system which shares many attributes with envisioned AV-based transit systems. Total fuel consumption and GHG emissions with and without an AMD are estimated, providing a range of potential system impacts on sustainability. The results of a previous case study based of a proposed implementation of PRT on the Kansas State University (KSU) campus in Manhattan, Kansas, serves as the basis to estimate personal miles traveled supplanted by an AMD at varying levels of service. The results show that an AMD has the potential to reduce total system fuel consumption and GHG emissions, but the amount is largely dependent on operating and ridership assumptions. The study points to the need to better understand ride-sharing scenarios and calls for future research on sustainability benefits of an AMD system at both vehicle and system levels.

  5. Performance Improvements for Coarse Mesh Finite Difference Acceleration L3:RTM.PRT.P13.02

    International Nuclear Information System (INIS)

    Collins, Benjamin S.; Hamilton, Steven P.; Stimpson, Shane; Yee, Ben; Larsen, Edward W.; Kochunas, Brendan

    2016-01-01

    The development of VERA-CS in recent years has focused on developing the capability to simulate multiple cycles of operating commercial nuclear power plants. Now that these capabilities have advanced to the point where it is being deployed to users, the focus is on improving the computational performance of various components in VERA-CS. In this work, the focus is on the Coarse Mesh Finite Difference (CMFD) solution in MPACT. CMFD serves multiple purposes in the 2D/1D solution methodology. First, it is a natural mechanism to tie together the radial MOC transport and the axial SP3 solution. Because the CMFD system solves the multigroup three-dimensional core in one system, it pulls together the global response of the system. In addition, the CMFD solution provides a framework to accelerate the convergence of the eigenvalue problem.

  6. Evaluating Opportunities to Enhance Hoosier State Train Ridership through a Survey of Riders’ Opinions and an Assessment of Access to the Line

    Science.gov (United States)

    2017-12-01

    Passenger rail is an integral part of intercity transportation networks, especially in areas where residents do not have access to a car or there are not any other options for intercity travel. The Hoosier State Train (HST) line connects five station...

  7. A Randomized Clinical Trial Comparison between Pivotal Response Treatment (PRT) and Structured Applied Behavior Analysis (ABA) Intervention for Children with Autism

    Science.gov (United States)

    Mohammadzaheri, Fereshteh; Koegel, Lynn Kern; Rezaee, Mohammad; Rafiee, Seyed Majid

    2014-01-01

    Accumulating studies are documenting specific motivational variables that, when combined into a naturalistic teaching paradigm, can positively influence the effectiveness of interventions for children with autism spectrum disorder (ASD). The purpose of this study was to compare two applied behavior analysis (ABA) intervention procedures, a…

  8. Formation of a PRT and the instrumentation of x-ray diffraction on the NSLS. Progress report, September 1, 1980-October 30, 1981

    International Nuclear Information System (INIS)

    Liedl, G.L.

    1981-09-01

    The Midwest Analytical Team for Research Instrumentation of X-Rays (MATRIX) was organized to formulate a research team to design, construct and utilize a port at NSLS for diffuse scattering. MATRIX, which was formally initiated in September of 1980 upon receipt of funding, consists of active members from Purdue University, Northwestern University, University of Illinois, Iowa State University, Michigan Technological University, University of Missouri, and Argonne National Laboratories. The Executive Committee and all design teams have met three times with two other meetings scheduled for 1981. The first year's design phase is near completion and has concentrated around the diffractometer system, beam line, and computer control system. Some changes which have influenced the design progress are the addition of a full time design person and the inclusion of added expertise in our design teams. These changes have accelerated our progress beyond the state originally estimated. These factors have made it possible to advance some aspects of our design, in particular, the monochromator-mirror design which had been reserved for the second year. The final design phase is expected to be completed in early 1982 with installation in late summer of 1982. Initial research on local atomic arrangements and lattice effects will then be initiated

  9. RPP-PRT-58489, Revision 1, One Systems Consistent Safety Analysis Methodologies Report. 24590-WTP-RPT-MGT-15-014

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Mukesh [URS Professional Solutions LLC, Aiken, SC (United States); Niemi, Belinda [Washington River Protection Solutions, LLC, Richland, WA (United States); Paik, Ingle [Washington River Protection Solutions, LLC, Richland, WA (United States)

    2015-09-02

    In 2012, One System Nuclear Safety performed a comparison of the safety bases for the Tank Farms Operations Contractor (TOC) and Hanford Tank Waste Treatment and Immobilization Plant (WTP) (RPP-RPT-53222 / 24590-WTP-RPT-MGT-12-018, “One System Report of Comparative Evaluation of Safety Bases for Hanford Waste Treatment and Immobilization Plant Project and Tank Operations Contract”), and identified 25 recommendations that required further evaluation for consensus disposition. This report documents ten NSSC approved consistent methodologies and guides and the results of the additional evaluation process using a new set of evaluation criteria developed for the evaluation of the new methodologies.

  10. Biofilm Formation on Stainless Steel by Streptococcus thermophilus UC8547 in Milk Environments Is Mediated by the Proteinase PrtS

    OpenAIRE

    Bassi, D.; Cappa, F.; Gazzola, S.; Orrù, L.; Cocconcelli, P. S.

    2017-01-01

    In Streptococcus thermophilus, gene transfer events and loss of ancestral traits over the years contribute to its high level of adaptation to milk environments. Biofilm formation capacity, a phenotype that is lost in the majority of strains, plays a role in persistence in dairy environments, such as milk pasteurization and cheese manufacturing plants. To investigate this property, we have studied S. thermophilus UC8547, a fast-acidifying dairy starter culture selected for its high capacity to...

  11. Interim report for documentation of computer programs for crude oil profile analysis. [Codes, CV, CRULE, CPR, CIMPACT, ENT ADJ, REF VOLS, CIMP PRT, C MODEL, C PRINT

    Energy Technology Data Exchange (ETDEWEB)

    This report is summarizing the findings and documenting the programs developed by Economic Regulatory Administration (ERA) for the Crude Oil Profile Analysis. Based on a variety of estimates and assumptions from different sources, ERA developed a series of computer programs which generate a 24-month projection of the crude oil production in each of the price categories. AVANTE International Systems Corporation is contracted to provide an organized documentation for all of these data base, assumptions, estimation rationale and computing procedures.

  12. Bioremediation Approaches for Treating Low Concentrations of N-Nitrosodimethylamine in Groundwater

    Science.gov (United States)

    2008-10-01

    Tate and Alexander, 1975, 1976; Mallik and Tesfai, 1981). The persistence of NDMA derived originally from 1,1-dimethylhydrazine- based rocket fuel over...metabolism: Organic carbon oxidation coupled to dissimilatory reduction of iron or manganese. Appl. Environ. Microbiol. 54:1472-1480. Mallik , M

  13. Double Bass

    Science.gov (United States)

    Askenfelt, Anders

    The study of the acoustics of bowed instruments has for several reasons focused on the violin. A substantial amount of knowledge has been accumulated over the last century (see Hutchins 1975, 1976; Hutchins and Benade 1997). The violin is discussed in Chap. 13, while the cello is discussed in Chap. 14. The bow is discussed in Chap. 16.

  14. Mapping pine mortality by aerial photography, Umstead State Park, North Carolina

    Science.gov (United States)

    Clarence J. DeMars; Garey W. Slaughter; Lnla E. Greene; John H. Ghent

    1982-01-01

    In 1975-1976, pine trees killed by the southern pine beetle Dendroctonus frontalis Zimm.) in a 2l70-hectare (5362-acre) area at the William B. Umstead State Park in central North Carolina, were monitored by sequential color infrared aerial photography. From 1973 through summer 1975, beetles in 350 infestation spots killed more than 20,500 pines on...

  15. Pontonides sympathes, a new species of commensal shrimp (Crustacea, Decapoda, Pontoniinae) from Antipatharia in the Galapagos Islands

    NARCIS (Netherlands)

    Ridder, de Ch.; Holthuis, L.B.

    1979-01-01

    During a stay at the Galapagos Islands (1975-1976), one of us (Ch. de Ridder) made a study of Gorgonaria and Antipatharia, paying special attention to commensals found with these corals. On Antipathes galapagensis Deichmann, 1941, a species of the pontoniine shrimp genus Pontonides was observed,

  16. List of Theses 1975 and 1976.

    Science.gov (United States)

    Espejo, Cristina Y., Comp.

    The fourth in a continuing series, this publication lists the masters' and doctoral theses on various aspects of mass communication concerning Asia submitted to colleges and universities in Asia and abroad in 1975-1976. The 93 entries are grouped into eight sections: general; advertising, management, and public relations; broadcast media; social…

  17. Existence of undiscovered Uranian satellites

    International Nuclear Information System (INIS)

    Boice, D.C.

    1986-04-01

    Structure in the Uranian ring system as observed in recent occultations may contain indirect evidence for the existence of undiscovered satellites. Using the Alfven and Arrhenius (1975, 1976) scenario for the formation of planetary systems, the orbital radii of up to nine hypothetical satellites interior to Miranda are computed. These calculations should provide interesting comparisons when the results from the Voyager 2 encounter with Uranus are made public. 15 refs., 1 fig., 1 tab

  18. Reprint of "Seismic monitoring of the Plosky Tolbachik eruption in 2012-2013 (Kamchatka Peninsula Russia)"

    Science.gov (United States)

    Senyukov, S. L.; Nuzhdina, I. N.; Droznina, S. Ya.; Garbuzova, V. T.; Kozhevnikova, T. Yu.; Sobolevskaya, O. V.; Nazarova, Z. A.; Bliznetsov, V. E.

    2015-12-01

    The active basaltic volcano Plosky Tolbachik (Pl. Tolbachik) is located in the southern part of the Klyuchevskoy volcano group on the Kamchatka Peninsula. The previous 1975-1976 Great Tolbachik Fissure Eruption (1975-1976 GTFE) occurred in the southern sector of Pl. Tolbachik. It was preceded by powerful earthquakes with local magnitudes between 2.5 and 4.9 and it was successfully predicted with a short-term forecast. The Kamchatka Branch of Geophysical Survey (KBGS) of the Russian Academy of Science (RAS) began to publish the results of daily seismic monitoring of active Kamchatka volcanoes on the Internet in 2000. Unlike the 1975-1976 GTFE precursor, (1) seismicity before the 2012-2013 Tolbachik Fissure Eruption (2012-2013 TFE) was relatively weak and earthquake magnitudes did not exceed 2.5. (2) Precursory earthquake hypocenters at 0-5 km depth were concentrated mainly under the southeastern part of the volcano. (3) The frequency of events gradually increased in September 2012, and rose sharply on the eve of the eruption. (4) According to seismic data, the explosive-effusive 2012-2013 TFE began at 05 h 15 min UTC on November 27, 2012; the outbreak occurred between the summit of the Pl. Tolbachik and the Northern Breakthrough of the 1975-1976 GTFE. (5) Because of bad weather, early interpretations of the onset time and the character of the eruption were made using seismological data only and were confirmed later by other monitoring methods. The eruption finished in early September 2013. This article presents the data obtained through real-time seismic monitoring and the results of retrospective analysis, with additional comments on the future monitoring of volcanic activity.

  19. Cost analysis of the Ohio nursing home industry.

    OpenAIRE

    Caswell, R J; Cleverley, W O

    1983-01-01

    This study was part of a major review of long-term care policy in the state of Ohio. The authors analyzed 1532 cost reports filed by nursing homes in 1975-1976 with the Ohio Medical Assistance (Medicaid) program. The objective was to guide policy on size (economies of scale), ownership, certification status, and reimbursement. Economies of scale were not found important: skilled nursing facilities (SNFs) offered the only evidence of operation below optimal scale, and the savings attributable ...

  20. Transit Rider Body Mass Index Before and After Completion of Street Light-Rail Line in Utah.

    Science.gov (United States)

    Brown, Barbara B; Smith, Ken R; Jensen, Wyatt A; Tharp, Doug

    2017-09-01

    To determine whether 2012 to 2015 (times 1-3) ridership changes correlated with body mass index (BMI) changes after transit line completion in Salt Lake City, Utah. We used Global Positioning System/accelerometry-measured transit ridership measures in 2012 to 2013 (times 1-2) to compare objective and self-reported ridership. Regression models related changes in objectively measured ridership (times 1-2) and self-reported ridership (times 1-2 and times 1-3) to BMI changes, adjusting for control variables. Objective and self-reported ridership measures were consistent. From time 1 to 2 (P = .021) or to 3 (P = .015), BMI increased among self-reported former riders and decreased among new riders (P = .09 for both times 1-2 and times 1-3), although the latter was nonsignificant. Time 3 attrition adjustment had no effect on results. Adjusting for baseline BMI, the nonsignificant effect for new riders remained nonsignificant, indicating no BMI change; the BMI increase after discontinuing transit remained significant. Observed BMI increases subsequent to stopping transit ridership persisted for more than 2 years (postintervention). These results suggest that transit ridership protects against BMI gains and support the need to provide convenient transit for public health.

  1. Chatbots no serviço de referência online:uma ferramenta para a gestão da biblioteca da PRT 13ª Região.

    OpenAIRE

    Henn, Gustavo

    2006-01-01

    This work proposes guidelines to construct a chatbot for digital reference service of Procuradoria Regional do Trabalho da 13a Região Library. For this, a exploratory bibliographic research was done. The activities had consisted in: (1) to explore the chatbots and digital reference service thematic and, (2) to define consultation types and reference questions that the chatbot will assist, besides proposing its interface and its personality. Concludes that the use of the chatbots in the digita...

  2. Physical Readiness Training: A Meta-Analysis

    National Research Council Canada - National Science Library

    Vickers, Jr, Ross R

    2007-01-01

    .... This meta-analysis of available PRT studies (k = 3) indicated that (a) Fitness gains in the PRT program were equal to the gains in traditional fitness programs, and (b) the injury rate (i.e., hazard ratio...

  3. 77 FR 30547 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2012-05-23

    .... Applicant: James Bruner, Comfort, TX; PRT-72932A The applicant requests a captive-bred wildlife registration... conducted by the applicant over a 5-year period. Applicant: James Bruner, Comfort, TX; PRT-72933A The...

  4. Integrating Civilian Agencies in Stability Operations

    Science.gov (United States)

    2009-01-01

    maternal health and nutrition, HIV/AIDS, infectious disease, population, family planning and related reproductive health, and health systems. GH is also... authoritative definition of the PRT goal. Several sources, including the PRT Charter,7 the ISAF PRT Handbook,8 and statements 6 Perito, 2005, p. 11

  5. 77 FR 298 - Endangered Species Receipt of Applications for Permit

    Science.gov (United States)

    2012-01-04

    ... fruit bat (Pteropus rodricensis) Applicant: Disney's Animal Kingdom, Lake Buena Vista, FL; PRT-812907... applicant over a 5-year period. Applicant: Feld Entertainment Inc., Vienna, VA; PRT-702230 The applicant... Anderson, Hastings, NE; PRT-59366A The applicant requests a permit to import a sport-hunted trophy of one...

  6. Space Transportation Technology Workshop: Propulsion Research and Technology

    Science.gov (United States)

    2000-01-01

    This viewgraph presentation gives an overview of the Space Transportation Technology Workshop topics, including Propulsion Research and Technology (PR&T) project level organization, FY 2001 - 2006 project roadmap, points of contact, foundation technologies, auxiliary propulsion technology, PR&T Low Cost Turbo Rocket, and PR&T advanced reusable technologies RBCC test bed.

  7. San Antonio's 1983 Bus Passenger Survey

    Science.gov (United States)

    1983-10-01

    Many transit operators routinely collect ridership data in order to provide a : basis for the planning of bus services. Often a survey is conducted of bus : riders to determine their riding habits, their views about the quality of : current service, ...

  8. Analyzing the Potential for High-speed Rail as Part of the Multimodal Transportation System in the United States' Midwest Corridor

    Directory of Open Access Journals (Sweden)

    Jeffrey C. Peters

    2014-06-01

    Full Text Available With increasing demand and rising fuel costs, both travel time and cost of current intercity passenger transportation modes are becoming increasingly relevant. Around the world, highspeed rail (HSR is seen as a way to alleviate demand on highways and at airports. Ridership is the critical element in determining the viability of a large capital, long-term transportation investment. This paper provides a systematic, consistent methodology for analyzing systemwide modal ridership with and without a proposed HSR network and analyzes the potential for highspeed rail as part of the existing multimodal transportation system in a region in terms of ridership. Considerations of capital investment (e.g., network design and HSR speed, along with exogenous demographic, technological, economic, and policy trends in the long-term, are used to project ridership over time. This study represents an important step toward a consistent, comprehensive economic analysis of HSR in the United States.

  9. Improving Travel Projections for Public Transportation

    Science.gov (United States)

    1995-08-01

    Public transportation use saves energy and reduces emissions by taking people : out of single passenger automobiles and putting them into high occupancy, energy : efficient transit vehicles. Furthermore, public transit ridership and vehicular : trip ...

  10. Integration of multi-modal public transportation systems.

    Science.gov (United States)

    2013-05-01

    Transit ridership may be sensitive to fares, travel times, waiting times, and access times, among other factors. Thus, : elastic demands are considered in formulations for maximizing the system welfare for conventional and flexible bus : services. Tw...

  11. Transit boardings estimation and simulation tool (TBEST) calibration for guideway and BRT modes : [summary].

    Science.gov (United States)

    2013-06-01

    As demand for public transportation grows, planning tools used by Florida Department of Transportation (FDOT) and other transit agencies must evolve to effectively predict changing patterns of ridership. A key tool for this purpose is the Transit Boa...

  12. Analysis of movable bus stop boarding and alighting areas : [summary].

    Science.gov (United States)

    2013-05-01

    Floridas transit ridership comprises persons from : varying demographic backgrounds, including : those with disabilities. An important goal for the : Florida Deaprtment of Transportation (FDOT) : and Florida transit agencies is to ensure that all ...

  13. A smartphone-based system for automated detection of walking.

    Science.gov (United States)

    2015-08-01

    Walking is the most effective mode of travel to access transit: transit hubs with higher residential and employment densities have higher : ridership levels because they serve areas where a large population is within a short walk of transit service. ...

  14. A Framework for Assessing Feasibility of Transit-Oriented Development (TOD) Project Sites

    Science.gov (United States)

    2017-09-01

    After the Second World War, the United States saw a decline in ridership on transit systems, which eventually resulted in the dismantling and abandonment of many rail systems. The primary mode of public transportation shifted from transit to buses. I...

  15. The influence of service planning decisions on rail transit success or failure.

    Science.gov (United States)

    2009-06-01

    Some United States metropolitan areas with rail transit systems enjoy ridership and productivity success while : others do not. This study examines the experiences of 11 U.S. metropolitan areas with between onr million and : five million persons to b...

  16. Bicycle-bus conflict area study.

    Science.gov (United States)

    2009-11-01

    Increasing bicycle use and bus ridership are both desirable policy goals : from a sustainability standpoint, but on city streets these two modes of : transport are often in conflict. While occupying opposite ends of the size : and weight spectrum, th...

  17. How does transportation affordability vary among TODs, TADs, and other areas?

    Science.gov (United States)

    2017-08-01

    Transit-oriented development (TOD) has gained popularity worldwide as a sustainable form of urbanism; it concentrates development near a transit station so as to reduce auto-dependency and increase ridership. Existing travel behavior studies in the c...

  18. An Assessment of Public Transport Facility in Johor Bahru: a case study in Taman Ungku Tun Aminah Area, Majlis Perbandaran Johor Bahru Tengah, Malaysia

    OpenAIRE

    Musarrat Zaman; Zahid Sultan; Maryam Fard; Abdulrahman Siyaka; Jia Chyi Pung

    2017-01-01

    Provision of public transport infrastructure is important to increase the ridership and at the same time decrease the use of private transport. Like the other Malaysian cities, Johor Bahru is mostly dependent on private vehicles such as motor cars and motor cycles. The ridership on public transport especially public bus is getting lower over the years. In this situation the sustainability in transportation and land use cannot be ensured. This paper aims to assess the public transport facility...

  19. How change of public transportation usage reveals fear of the SARS virus in a city.

    Science.gov (United States)

    Wang, Kuo-Ying

    2014-01-01

    The outbreaks of the severe acute respiratory syndrome (SARS) epidemic in 2003 resulted in unprecedented impacts on people's daily life. One of the most significant impacts to people is the fear of contacting the SARS virus while engaging daily routine activity. Here we use data from daily underground ridership in Taipei City and daily reported new SARS cases in Taiwan to model the dynamics of the public fear of the SARS virus during the wax and wane of the SARS period. We found that for each reported new SARS case there is an immediate loss of about 1200 underground ridership (the fresh fear). These daily loss rates dissipate to the following days with an e-folding time of about 28 days, reflecting the public perception on the risk of contacting SARS virus when traveling with the underground system (the residual fear). About 50% of daily ridership was lost during the peak of the 2003 SARS period, compared with the loss of 80% daily ridership during the closure of the underground system after Typhoon Nari, the loss of 50-70% ridership due to the closure of the governmental offices and schools during typhoon periods, and the loss of 60% daily ridership during Chinese New Year holidays.

  20. How change of public transportation usage reveals fear of the SARS virus in a city.

    Directory of Open Access Journals (Sweden)

    Kuo-Ying Wang

    Full Text Available The outbreaks of the severe acute respiratory syndrome (SARS epidemic in 2003 resulted in unprecedented impacts on people's daily life. One of the most significant impacts to people is the fear of contacting the SARS virus while engaging daily routine activity. Here we use data from daily underground ridership in Taipei City and daily reported new SARS cases in Taiwan to model the dynamics of the public fear of the SARS virus during the wax and wane of the SARS period. We found that for each reported new SARS case there is an immediate loss of about 1200 underground ridership (the fresh fear. These daily loss rates dissipate to the following days with an e-folding time of about 28 days, reflecting the public perception on the risk of contacting SARS virus when traveling with the underground system (the residual fear. About 50% of daily ridership was lost during the peak of the 2003 SARS period, compared with the loss of 80% daily ridership during the closure of the underground system after Typhoon Nari, the loss of 50-70% ridership due to the closure of the governmental offices and schools during typhoon periods, and the loss of 60% daily ridership during Chinese New Year holidays.

  1. Douglas Davis / Douglas Davis ; interv. Tilman Baumgärtel

    Index Scriptorium Estoniae

    Davis, Douglas

    2006-01-01

    Ameerika kunstnikust Douglas Davisest (sünd. 1933) ja tema loonmingust, intervjuu kunstnikuga 8. 05. 1999 Osnabrückis. D. Davis oma interaktiivsetest performance'itest "Austrian Tapes" ja "Florence Tapes" (1970-ndad), Interneti-projektist "Terrible Beauty", sateliidiperformance'ist "Seven Thoughts" (1976), teleperformance'ist "The Last Nine Minutes" (1977), Vitali Komari ja Aleksander Melamidiga koos tehtud projektist "Questions Moscow New York" (1975-1976), võrguprojektidest "The World's Longest Sentence" (1994, asub New Yorgi Whitney Muuseumis), "MetaBody" jm.

  2. Annual report of the Gama Atomic Energy Research Centre, National Atomic Energy Agency, April 1975-March 1976

    International Nuclear Information System (INIS)

    1976-01-01

    Contents of this 1975-1976 Annual Report include organization structure personnel, procurement and acquisition of laboratory materials and equipment, maintenance of laboratory equipments, budgeting and financial accounts, preliminary fundamental research on plasma physics and particle physics, development of several prototypes of radiation detectors, construction of prototypes of high voltage tension, research in reactor physics, construction of BATAN Yogyakarta nuclear reactor, development of electronic equipment prototypes for reactor instrumentation, research on radiochemistry and radiation chemistry, preliminary research on uranium extraction using organic solvents, laboratory scale heavy water separation by distillation method, and research publication list. The institute's programmes for 1976-1977 are summarized. (author)

  3. El joven Joyce y el pathos del lenguaje

    Directory of Open Access Journals (Sweden)

    Julieta De Battista

    Full Text Available Este artículo ofrece una construcción del caso Joyce como un relato clínico a partir de los lineamientos que Lacan subrayó en 1975-1976. Metodológicamente se basa en la obra autobiográfica sobre la infancia y adolescencia de James Joyce y ofrece una lectura de la constelación original del nacimiento, la posición fundacional de la orientación subjetiva, los efectos del rechazo y el pathos singular que lo aquejaba: las palabras impuestas o experiencia del lenguaje parásito.

  4. Pivotal response treatment for autism spectrum disorder: current perspectives

    Directory of Open Access Journals (Sweden)

    Lei J

    2017-06-01

    Full Text Available Jiedi Lei, Pamela Ventola Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA Abstract: Pivotal response treatment (PRT is an evidence-based behavioral intervention based on applied behavior analysis principles aimed to improve social communication skills in individuals with autism spectrum disorder (ASD. PRT adopts a more naturalistic approach and focuses on using a number of strategies to help increase children’s motivation during intervention. Since its conceptualization, PRT has received much empirical support for eliciting therapeutic gains in greater use of functional social communication skills in individuals with ASD. Building upon the empirical evidence supporting PRT, recent advancements have increasingly turned to using interdisciplinary research integrating neuroimaging techniques and behavioral measures to help identify objective biomarkers of treatment, which have two primary purposes. First, neuroimaging results can help characterize how PRT may elicit change, and facilitate partitioning of the heterogeneous profiles of neural mechanisms underlying similar profile of behavioral changes observed over PRT. Second, neuroimaging provides an objective means to both map and track how biomarkers may serve as reliable and sensitive predictors of responder profiles to PRT, assisting clinicians to identify who will most likely benefit from PRT. Together, a better understanding of both mechanisms of change and predictors of responder profile will help PRT to serve as a more precise and targeted intervention for individuals with ASD, thus moving towards the goal of precision medicine and improving quality of care. This review focuses on the recent emerging neuroimaging evidences supporting PRT, offering current perspectives on the importance of interdisciplinary research to help clinicians better understand how PRT works and predict who will respond to PRT. Keywords: PRT, ASD, biomarkers, neuroimaging

  5. Support to X-33/Resusable Launch Vehicle Technology Program

    Science.gov (United States)

    2000-01-01

    The X-33 Guidance, Navigation, and Control (GN&C) Peer Review Team (PRT) was formed to assess the integrated X-33 vehicle GN&C system in order to identify any areas of disproportionate risk for initial flight. The eventual scope of the PRT assessment encompasses the GN&C algorithms, software, avionics, control effectors, applicable models, and testing. The initial (phase 1) focus of the PRT was on the GN&C algorithms and the Flight Control Actuation Subsystem (FCAS). The PRT held meetings during its phase 1 assessment at X-33 assembly facilities in Palmdale, California on May 17-18, 2000 and at Honeywell facilities in Tempe, Arizona on June 7, 2000. The purpose of these meetings was for the PRT members to get background briefings on the X-33 vehicle and for the PRT team to be briefed on the design basis and current status of the X-33 GN&C algorithms as well as the FCAS. The following material is covered in this PRT phase 1 final report. Some significant GN&C-related accomplishments by the X-33 development team are noted. Some topics are identified that were found during phase 1 to require fuller consideration when the PRT reconvenes in the future. Some new recommendations by the PRT to the X-33 program will likely result from a thorough assessment of these subjects. An initial list of recommendations from the PRT to the X-33 program is provided. These recommendations stem from topics that received adequate review by the PRT in phase 1. Significant technical observations by the PRT members as a result of the phase 1 meetings are detailed. (These are covered in an appendix.) There were many X-33 development team members who contributed to the technical information used by the PRT during the phase 1 assessment, who supported presentations to the PRT, and who helped to address the many questions posed by the PRT members at and after the phase 1 meetings. In all instances the interaction between the PRT and the X-33 development team members was cordial and very

  6. Implementing peer review of teaching: a guide for dental educators.

    Science.gov (United States)

    Cunningham, I M; Johnson, I; Lynch, C D

    2017-04-07

    Peer review of teaching (PRT) is well established and valued within higher education. Increasingly, dental educators involved in undergraduate or postgraduate teaching are required to undertake PRT as part of their teaching development. Despite this, there is a paucity of literature relating to PRT within dental education, and none that considers the implementation of PRT within large dental teaching establishments. This article describes in detail a staged process for the planning and implementation of PRT within a UK dental school. It uses relevant educational literature to supplement the authors' experiences and recommendations. By highlighting aspects of the process which are key to successful implementation, it is a useful guide for all dental educator teams who wish to successfully introduce, restructure or refresh a PRT scheme.

  7. Solar Powered Remediation and pH Control

    Science.gov (United States)

    2017-04-13

    zone. The PRT system was completely powered via an off-the-grid solar power system . The system consisted of four 85 watt photovoltaic solar panels...polarity of the proton reduction system can be periodically alternated (i.e., the anode becomes a cathode) to increase the size of the treatment area, to...PRT System The PRT system was completely powered via an off-the-grid solar power system . The system consisted of four 85 watt photovoltaic solar

  8. Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?

    DEFF Research Database (Denmark)

    Kjølhede, Tue; Siemonsen, Susanne; Wenzel, Damian

    2017-01-01

    BACKGROUND: Multiple sclerosis (MS) is characterised by accelerated brain atrophy, which relates to disease progression. Previous research shows that progressive resistance training (PRT) can counteract brain atrophy in other populations. OBJECTIVE: To evaluate the effects of PRT by magnetic...... lifestyle followed by PRT). Assessments included disability measures and MRI (lesion load, global brain volume, percentage brain volume change (PBVC) and cortical thickness). RESULTS: While the MS Functional Composite score improved, Expanded Disability Status Scale, lesion load and global brain volumes did...

  9. 78 FR 16292 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2013-03-14

    ... Lorisidae Rhinocerotidae Tapiridae Gruidae Threskiornithidae Genus: Tragopan Species: Koala (Phascolarctos cinereus) Applicant: Field Museum of Natural History, Chicago, IL; PRT-698170 The applicant requests...

  10. Pulsed Radiation Therapy With Concurrent Cisplatin Results in Superior Tumor Growth Delay in a Head and Neck Squamous Cell Carcinoma Murine Model

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Kurt; Krueger, Sarah A.; Kane, Jonathan L.; Wilson, Thomas G.; Hanna, Alaa; Dabjan, Mohamad; Hege, Katie M.; Wilson, George D.; Grills, Inga; Marples, Brian, E-mail: brian.marples@beaumont.edu

    2016-09-01

    Purpose: To assess the efficacy of 3-week schedules of low-dose pulsed radiation treatment (PRT) and standard radiation therapy (SRT), with concurrent cisplatin (CDDP) in a head and neck squamous cell carcinoma xenograft model. Methods and Materials: Subcutaneous UT-SCC-14 tumors were established in athymic NIH III HO female mice. A total of 30 Gy was administered as 2 Gy/d, 5 d/wk for 3 weeks, either by PRT (10 × 0.2 Gy/d, with a 3-minute break between each 0.2-Gy dose) or SRT (2 Gy/d, uninterrupted delivery) in combination with concurrent 2 mg/kg CDDP 3 times per week in the final 2 weeks of radiation therapy. Treatment-induced growth delays were defined from twice-weekly tumor volume measurements. Tumor hypoxia was assessed by {sup 18}F-fluoromisonidazole positron emission tomography imaging, and calculated maximum standardized uptake values compared with tumor histology. Tumor vessel density and hypoxia were measured by quantitative immunohistochemistry. Normal tissues effects were evaluated in gut and skin. Results: Untreated tumors grew to 1000 mm{sup 3} in 25.4 days (±1.2), compared with delays of 62.3 days (±3.5) for SRT + CDDP and 80.2 days (±5.0) for PRT + CDDP. Time to reach 2× pretreatment volume ranged from 8.2 days (±1.8) for untreated tumors to 67.1 days (±4.7) after PRT + CDDP. Significant differences in tumor growth delay were observed for SRT versus SRT + CDDP (P=.04), PRT versus PRT + CDDP (P=.035), and SRT + CDDP versus PRT + CDDP (P=.033), and for survival between PRT versus PRT + CDDP (P=.017) and SRT + CDDP versus PRT + CDDP (P=.008). Differences in tumor hypoxia were evident by {sup 18}F-fluoromisonidazole positron emission tomography imaging between SRT and PRT (P=.025), although not with concurrent CDDP. Tumor vessel density differed between SRT + CDDP and PRT + CDDP (P=.011). No differences in normal tissue parameters were seen. Conclusions: Concurrent CDDP was more effective in combination PRT than SRT at

  11. Estimating the Need for Palliative Radiation Therapy: A Benchmarking Approach

    Energy Technology Data Exchange (ETDEWEB)

    Mackillop, William J., E-mail: william.mackillop@krcc.on.ca [Cancer Care and Epidemiology, Queen' s Cancer Research Institute, Queen' s University, Kingston, Ontario (Canada); Department of Public Health Sciences, Queen' s University, Kingston, Ontario (Canada); Department of Oncology, Queen' s University, Kingston, Ontario (Canada); Kong, Weidong [Cancer Care and Epidemiology, Queen' s Cancer Research Institute, Queen' s University, Kingston, Ontario (Canada)

    2016-01-01

    Purpose: Palliative radiation therapy (PRT) benefits many patients with incurable cancer, but the overall need for PRT is unknown. Our primary objective was to estimate the appropriate rate of use of PRT in Ontario. Methods and Materials: The Ontario Cancer Registry identified patients who died of cancer in Ontario between 2006 and 2010. Comprehensive RT records were linked to the registry. Multivariate analysis identified social and health system-related factors affecting the use of PRT, enabling us to define a benchmark population of patients with unimpeded access to PRT. The proportion of cases treated at any time (PRT{sub lifetime}), the proportion of cases treated in the last 2 years of life (PRT{sub 2y}), and number of courses of PRT per thousand cancer deaths were measured in the benchmark population. These benchmarks were standardized to the characteristics of the overall population, and province-wide PRT rates were then compared to benchmarks. Results: Cases diagnosed at hospitals with no RT on-site and residents of poorer communities and those who lived farther from an RT center, were significantly less likely than others to receive PRT. However, availability of RT at the diagnosing hospital was the dominant factor. Neither socioeconomic status nor distance from home to nearest RT center had a significant effect on the use of PRT in patients diagnosed at a hospital with RT facilities. The benchmark population therefore consisted of patients diagnosed at a hospital with RT facilities. The standardized benchmark for PRT{sub lifetime} was 33.9%, and the corresponding province-wide rate was 28.5%. The standardized benchmark for PRT{sub 2y} was 32.4%, and the corresponding province-wide rate was 27.0%. The standardized benchmark for the number of courses of PRT per thousand cancer deaths was 652, and the corresponding province-wide rate was 542. Conclusions: Approximately one-third of patients who die of cancer in Ontario need PRT, but many of them are never

  12. Evaluating the attractiveness of a new light rail extension: Testing simple change and displacement change hypotheses.

    Science.gov (United States)

    Werner, Carol M; Brown, Barbara B; Tribby, Calvin P; Tharp, Doug; Flick, Kristi; Miller, Harvey J; Smith, Ken R; Jensen, Wyatt

    2016-01-01

    Many communities in the United States have been adding new light rail to bus-predominant public transit systems. However, there is disagreement as to whether opening light rail lines attracts new ridership or merely draws ridership from existing transit users. We study a new light rail line in Salt Lake City, Utah, USA, which is part of a complete street redevelopment. We utilize a pre-test post-test control group quasi-experimental design to test two different measures of ridership change. The first measure is calculated from stops along the light rail route; the second assumes that nearby bus stops might be displaced by the rail and calculates ridership change with those stops included as baseline. Both the simple measure (transit use changes on the complete street light rail corridor) and the "displacement" measure (transit use changes in the one-quarter mile catchment areas around new light rail stops) showed significant ( p rail bus users. In particular, the displacement analysis discredits a common challenge that when a new light rail line opens, most passengers are simply former bus riders whose routes were canceled in favor of light rail. The study suggests that light rail services can attract additional ridership to public transit systems. In addition, although pre-post control-group designs require time and effort, this project underscores the benefits of such quasi-experimental designs in terms of the strength of the inferences that can be drawn about the impacts of new transit infrastructure and services.

  13. The Indispensable N-Terminal Half of elF3j/HCR1 Cooperates with its Structurally Conserved Binding Partner eIF3b/PRT1-RRM and with eIF1A in Stringent AUG Selection

    Czech Academy of Sciences Publication Activity Database

    ElAntak, L.; Wagner, Susan; Herrmannová, Anna; Karásková, Martina; Rutkai, Edit; Lukavsky, P. J.; Valášek, Leoš

    2010-01-01

    Roč. 396, č. 4 (2010), s. 1097-1116 ISSN 0022-2836 Institutional research plan: CEZ:AV0Z50200510 Keywords : translation initiation * AUG recognition * eIF3 Subject RIV: CE - Biochemistry Impact factor: 4.008, year: 2010

  14. Ship motion effects in CTD-data from weakly stratified waters of the Puerto Rico trench

    NARCIS (Netherlands)

    van Haren, H.

    2015-01-01

    Shipborne SBE 911plus Conductivity Temperature Depth (CTD)-casts have been made to maximum 7220 m in the Puerto Rico Trench (PRT). In PRT-waters from 5500 m and deeper and specifically below the 6500 m transition to the hadal-zone, the vertical density stratification is found very weak, with

  15. Antecedents and Consequences of Parental Rights Termination for Abused and Neglected Children.

    Science.gov (United States)

    Borgman, Robert

    1981-01-01

    This study of 29 adopted children examines the consequences of parental rights termination (PRT) for neglected or abused children in relation to antecedent characteristics of children, parents, and circumstances in the foster care process. Suggests alternative plans for children whose PRT has not been followed by permanent adoptive placement.…

  16. Peer Collaboration: Improving Teaching through Comprehensive Peer Review

    Science.gov (United States)

    Smith, Shelley L.

    2014-01-01

    This article includes a brief rationale and review of the literature on peer review of teaching (PRT). Based on that literature review, it offers a proposal for an optimal formative review process that results in a teaching portfolio that would reflect a faculty member's efforts and successes in a critically reflective PRT process, and contributes…

  17. The Effectiveness of Peer Review of Teaching When Performed between Early-Career Academics

    Science.gov (United States)

    Woodman, Richard J.; Parappilly, Maria B.

    2015-01-01

    The success of peer review of teaching (PRT) in shaping teaching practice during an academic's formative years may depend on the peers' teaching experience and the frequency of evaluation. Two Australian early-career University lecturers with no previous experience of peer review performed a single PRT on one another following a one week academic…

  18. 78 FR 50083 - Endangered Species; Marine Mammals; Receipt of Applications for Permit

    Science.gov (United States)

    2013-08-16

    ... a 5-year period. Applicant: Zoological Society of San Diego, San Diego, CA; PRT-08827B The applicant requests a permit to re-import a live female African elephant (Loxodonta africana) born in the wild for the... conducted by the applicant over a 5-year period. Applicant: Pinto Ranch, Hunt, TX; PRT-13263B The applicant...

  19. The Effect of Pivotal Response Treatment in Children with Autism Spectrum Disorders: A Non-Randomized Study with a Blinded Outcome Measure

    Science.gov (United States)

    Duifhuis, E. A.; den Boer, J. C.; Doornbos, A.; Buitelaar, J. K.; Oosterling, I. J.; Klip, H.

    2017-01-01

    Purpose of this quasi-experimental trial was to investigate the effect of Pivotal response treatment (PRT) versus treatment as usual (TAU) on autism symptoms. Children with autism spectrum disorder (ASD), aged 3-8 years, received either PRT (n = 11) or TAU (n = 13). Primary outcome measure was the total score on the Autism Diagnostic Observation…

  20. Pivotal Response Treatment for Infants At-Risk for Autism Spectrum Disorders: A Pilot Study

    Science.gov (United States)

    Steiner, Amanda Mossman; Gengoux, Grace W.; Klin, Ami; Chawarska, Katarzyna

    2013-01-01

    Presently there is limited research to suggest efficacious interventions for infants at-risk for autism. Pivotal response treatment (PRT) has empirical support for use with preschool children with autism, but there are no reports in the literature utilizing this approach with infants. In the current study, a developmental adaptation of PRT was…

  1. The Effect of Pivotal Response Treatment in Children with Autism Spectrum Disorders: A Non-randomized Study with a Blinded Outcome Measure

    NARCIS (Netherlands)

    Duifhuis, E.A.; Boer, J.C. den; Doornbos, A.; Buitelaar, J.K.; Oosterling, I.J.; Klip, H.

    2017-01-01

    Purpose of this quasi-experimental trial was to investigate the effect of Pivotal response treatment (PRT) versus treatment as usual (TAU) on autism symptoms. Children with autism spectrum disorder (ASD), aged 3-8 years, received either PRT (n = 11) or TAU (n = 13). Primary outcome measure was the

  2. Covalent Modification of Human Serum Albumin by the Natural Sesquiterpene Lactone Parthenolide

    Directory of Open Access Journals (Sweden)

    Michael Plöger

    2015-04-01

    Full Text Available The reactivity of parthenolide (PRT, a natural sesquiterpene lactone from Tanacetum parthenium (Asteraceae, with human serum albumin (HSA was studied by UHPLC/+ESI-QqTOF MS analysis after tryptic digestion of albumin samples after incubation with this compound. It was found that the single free cysteine residue, C34, of HSA (0.6 mM reacted readily with PRT when incubated at approximately 13-fold excess of PRT (8 mM. Time-course studies with PRT and its 11β,13-dihydro derivative at equimolar ratios of the reactants revealed that PRT under the chosen conditions reacts preferably with C34 and does so exclusively via its α-methylene-γ-lactone moiety, while the epoxide structure is not involved in the reaction.

  3. Feasibility and efficacy of progressive resistance training and dietary supplements in radiotherapy treated head and neck cancer patients - the DAHANCA 25A study

    DEFF Research Database (Denmark)

    Lønbro, Simon; Dalgas, Ulrik; Primdahl, Hanne

    2013-01-01

    weeks of PRT ± protein and creatine supplementation among HNSCC patients. Secondly, to investigate group changes over time and group differences regarding lean body mass (LBM), muscle strength and functional performance following PRT ± dietary supplementation. Material and methods. Thirty patients were...... supplementation. Before the pre-trial and pre- and post-PRT evaluation of LBM, maximal isometric and isokinetic muscle strength and functional performance were performed. Results. Seventy percent of the patients completed the intervention and the PRT adherence rate was 97%. No significant group differences were...... found in any endpoints. From pre- to post-PRT, LBM increased significantly in the PROCR group by 2.6 ± 2.2 kg (p

  4. What works for you? Using teacher feedback to inform adaptations of pivotal response training for classroom use.

    Science.gov (United States)

    Stahmer, Aubyn C; Suhrheinrich, Jessica; Reed, Sarah; Schreibman, Laura

    2012-01-01

    Several evidence-based practices (EBPs) have been identified as efficacious for the education of students with autism spectrum disorders (ASD). However, effectiveness research has rarely been conducted in schools and teachers express skepticism about the clinical utility of EBPs for the classroom. Innovative methods are needed to optimally adapt EBPs for community use. This study utilizes qualitative methods to identify perceived benefits and barriers of classroom implementation of a specific EBP for ASD, Pivotal Response Training (PRT). Teachers' perspectives on the components of PRT, use of PRT as a classroom intervention strategy, and barriers to the use of PRT were identified through guided discussion. Teachers found PRT valuable; however, they also found some components challenging. Specific teacher recommendations for adaptation and resource development are discussed. This process of obtaining qualitative feedback from frontline practitioners provides a generalizable model for researchers to collaborate with teachers to optimally promote EBPs for classroom use.

  5. Photoradiation therapy of animal tumors and nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Zhao, S.P.; Tao, Z.D.; Xiao, J.Y.; Peng, Y.Y.; Yang, Y.H.; Zeng, Q.S.; Liu, Z.W.

    1990-01-01

    Both animal tumors and human nasopharyngeal carcinoma were submitted to a photoradiation therapy (PRT) trial in order to determine the efficacy and side effects of PRT, as well as to elucidate its mechanism of cytotoxicity. In animal tumors, the inhibition rate was 70%, and of 20 patients, eight achieved complete remission, and ten, significant remission, with an overall response rate of 90%. The blood picture and the values of serum IgG, IgM, IgA, and C3 all remained stable post-PRT. Only three patients developed mild generalized skin photosensitive reactions, and these did not affect subsequent treatment. There was no immunosuppressive effect as evidenced by a tritium-labeled thymidine-incorporated lymphocytoblast transformation assay performed both before and after PRT. Ultrastructural studies at different time intervals after PRT highly suggested that the mitochondria and rough endoplasmic reticulum were among the first organelles to be damaged

  6. Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design.

    Science.gov (United States)

    Evans, Genevieve L; Furkert, Daniel P; Abermil, Nacim; Kundu, Preeti; de Lange, Katrina M; Parker, Emily J; Brimble, Margaret A; Baker, Edward N; Lott, J Shaun

    2018-02-01

    Phosphoribosyltransferases (PRTs) bind 5'-phospho-α-d-ribosyl-1'-pyrophosphate (PRPP) and transfer its phosphoribosyl group (PRib) to specific nucleophiles. Anthranilate PRT (AnPRT) is a promiscuous PRT that can phosphoribosylate both anthranilate and alternative substrates, and is the only example of a type III PRT. Comparison of the PRPP binding mode in type I, II and III PRTs indicates that AnPRT does not bind PRPP, or nearby metals, in the same conformation as other PRTs. A structure with a stereoisomer of PRPP bound to AnPRT from Mycobacterium tuberculosis (Mtb) suggests a catalytic or post-catalytic state that links PRib movement to metal movement. Crystal structures of Mtb-AnPRT in complex with PRPP and with varying occupancies of the two metal binding sites, complemented by activity assay data, indicate that this type III PRT binds a single metal-coordinated species of PRPP, while an adjacent second metal site can be occupied due to a separate binding event. A series of compounds were synthesized that included a phosphonate group to probe PRPP binding site. Compounds containing a "bianthranilate"-like moiety are inhibitors with IC 50 values of 10-60μM, and K i values of 1.3-15μM. Structures of Mtb-AnPRT in complex with these compounds indicate that their phosphonate moieties are unable to mimic the binding modes of the PRib or pyrophosphate moieties of PRPP. The AnPRT structures presented herein indicated that PRPP binds a surface cleft and becomes enclosed due to re-positioning of two mobile loops. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Progressive resistance training rebuilds lean body mass in head and neck cancer patients after radiotherapy – Results from the randomized DAHANCA 25B trial

    International Nuclear Information System (INIS)

    Lønbro, Simon; Dalgas, Ulrik; Primdahl, Hanne; Johansen, Jørgen; Nielsen, Jakob Lindberg; Aagaard, Per; Hermann, Anne Pernille; Overgaard, Jens; Overgaard, Kristian

    2013-01-01

    Purpose: The critical weight loss observed in head and neck squamous cell carcinoma (HNSCC) patients following radiotherapy is mainly due to loss of lean body mass. This is associated with decreases in muscle strength, functional performance and Quality of Life (QoL). The present study investigated the effect of progressive resistance training (PRT) on lean body mass, muscle strength and functional performance in HNSCC patients following radiotherapy. Patients and methods: Following radiotherapy HNSCC patients were randomized into two groups: Early Exercise (EE, n = 20) initiated 12 weeks of PRT followed by 12 weeks of self-chosen physical activity. Delayed Exercise (DE, n = 21) initiated 12 weeks of self-chosen physical activity followed by 12 weeks of PRT. Lean body mass, muscle strength, functional performance and QoL were evaluated at baseline and after week 12 and 24. Results: In the first 12 weeks lean body mass increased by 4.3% in EE after PRT and in the last 12 weeks by 4.2% in DE after PRT. These increases were significantly larger than the changes after self-chosen physical activity (p ⩽ 0.005). Regardless of PRT start-up time, the odds ratio of increasing lean body mass by more than 4% after PRT was 6.26 (p < 0.05). PRT significantly increased muscle strength, whereas functional performance increased significantly more than after self-chosen physical activity only after delayed onset of PRT. Overall QoL improved significantly more in EE than DE from baseline to week 12. Conclusion: PRT effectively increased lean body mass and muscle strength in HNSCC patients following radiotherapy, irrespectively of early or delayed start-up

  8. Sequence analysis of PROTEOLYSIS 6 from Solanum lycopersicum

    Science.gov (United States)

    Roslan, Nur Farhana; Chew, Bee Lyn; Goh, Hoe-Han; Isa, Nurulhikma Md

    2018-04-01

    The N-end rule pathway is a protein degradation pathway that relates the protein half-life with the identity of its N-terminal residues. A destabilizing N-terminal residues is created by enzymatic reaction or chemical modifications. This destabilized substrate will be recognized by PROTEOLYSIS 6 (PRT6) protein, which encodes an E3 ligase enzyme and resulted in substrate degradation by proteasome. PRT6 has been studied in Arabidopsis thaliana and barley but not yet been studied in fleshy fruit plants. Hence, this study was carried out in tomato that is known as the model for fleshy fruit plants. BLASTX analysis identified that Solyc09g010830 which encodes for a PRT6 gene in tomato based on its sequence similarity with PRT6 in A. thaliana. In silico gene expression analysis shows that PRT6 gene was highly expressed in tomato fruits breaker +5. Co-expression analysis shows that PRT6 may not only involved in abiotic stresses but also in biotic stresses. The objective is to analyze the sequence and characterize PRT6 gene in tomato.

  9. N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway.

    Science.gov (United States)

    Zhang, Hongtao; Gannon, Lucy; Hassall, Kirsty L; Deery, Michael J; Gibbs, Daniel J; Holdsworth, Michael J; van der Hoorn, Renier A L; Lilley, Kathryn S; Theodoulou, Frederica L

    2018-05-01

    The N-end rule pathway of targeted protein degradation is an important regulator of diverse processes in plants but detailed knowledge regarding its influence on the proteome is lacking. To investigate the impact of the Arg/N-end rule pathway on the proteome of etiolated seedlings, we used terminal amine isotopic labelling of substrates with tandem mass tags (TMT-TAILS) for relative quantification of N-terminal peptides in prt6, an Arabidopsis thaliana N-end rule mutant lacking the E3 ligase PROTEOLYSIS6 (PRT6). TMT-TAILS identified over 4000 unique N-terminal peptides representing c. 2000 protein groups. Forty-five protein groups exhibited significantly increased N-terminal peptide abundance in prt6 seedlings, including cruciferins, major seed storage proteins, which were regulated by Group VII Ethylene Response Factor (ERFVII) transcription factors, known substrates of PRT6. Mobilisation of endosperm α-cruciferin was delayed in prt6 seedlings. N-termini of several proteases were downregulated in prt6, including RD21A. RD21A transcript, protein and activity levels were downregulated in a largely ERFVII-dependent manner. By contrast, cathepsin B3 protein and activity were upregulated by ERFVIIs independent of transcript. We propose that the PRT6 branch of the pathway regulates protease activities in a complex manner and optimises storage reserve mobilisation in the transition from seed to seedling via control of ERFVII action. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

  10. Exercise in myasthenia gravis: A feasibility study of aerobic and resistance training.

    Science.gov (United States)

    Rahbek, Martin Amadeus; Mikkelsen, Erik Elgaard; Overgaard, Kristian; Vinge, Lotte; Andersen, Henning; Dalgas, Ulrik

    2017-10-01

    It has not been established whether progressive resistance training (PRT) and aerobic training (AT) are feasible and efficient in myasthenia gravis (MG). Fifteen subjects with generalized MG (Myasthenia Gravis Foundation of America (MGFA) clinical classification II-IV) were randomly assigned to 20 training sessions during 8 weeks of either PRT or AT. Feasibility was evaluated based on adherence, drop-out rate, adverse events, and Quantitative Myasthenia Gravis (QMG) score. Twelve subjects (MGFA II, n = 11; MGFA III, n=1) completed the intervention with a mean adherence of 95 % ± 8. One dropout (PRT) could potentially be related to PRT. Both groups reported adverse events, including bulbar symptoms (n = 2) and increased fatigue (n = 3), but no change in QMG score was observed in either group. The PRT group showed increases in maximal strength and functional capacity. Eight weeks of moderate to high intensity AT and PRT were feasible for most patients with mild MG. Maximal strength and functional capacity increased in the PRT group. Muscle Nerve 56: 700-709, 2017. © 2017 Wiley Periodicals, Inc.

  11. Molecular characterization of a subtilase from the vascular wilt fungus Fusarium oxysporum.

    Science.gov (United States)

    Di Pietro, A; Huertas-González, M D; Gutierrez-Corona, J F; Martínez-Cadena, G; Méglecz, E; Roncero, M I

    2001-05-01

    The gene prt1 was isolated from the tomato vascular wilt fungus Fusarium oxysporum f. sp. lycopersici, whose predicted amino acid sequence shows significant homology with subtilisin-like fungal proteinases. Prt1 is a single-copy gene, and its structure is highly conserved among different formae speciales of F. oxysporum. Prt1 is expressed constitutively at low levels during growth on different carbon and nitrogen sources and strongly induced in medium containing collagen and glucose. As shown by reverse transcription-polymerase chain reaction and fluorescence microscopy of F. oxysporum strains carrying a prt1-promoter-green fluorescent protein fusion, prt1 is expressed at low levels during the entire cycle of infection on tomato plants. F. oxysporum strains transformed with an expression vector containing the prt1 coding region fused to the inducible endopolygalacturonase pg1 gene promoter and grown under promoter-inducing conditions secreted high levels of extracellular subtilase activity that resolved into a single peak of pI 4.0 upon isoelectric focusing. The active fraction produced two clearing bands of 29 and 32 kDa in sodium dodecyl sulfate gels containing gelatin. Targeted inactivation of prt1 in F. oxysporum f. sp. lycopersici had no detectable effect on mycelial growth, sporulation, and pathogenicity on tomato plants.

  12. The development of the market for neutron transmutation doped silicon

    International Nuclear Information System (INIS)

    Herzer, H.; Vieweg-Gutberlet, G.

    1984-01-01

    Neutron transmutation doped silicon was introduced to the electronic device market in the 1975-1976 time period. Today, neutron transmutation doping is definitely a mature technology applied mainly to semiconductor power devices. There is no doubt that the power device sector will remain the major consumer of NTD silicon in the near future. This paper examines the possible application of NTD silicon to other areas of the semiconductor market, and concludes that the need for NTD silicon will continue to grow and will expand into other applications. Consequently, unless new reactor capacities become available by the end of the decade, NTD silicon applications will probably be limited mainly to power and sensor devices

  13. Evidence for 20th century climate warming and wetland drying in the North American Prairie Pothole Region

    Science.gov (United States)

    Werner, B.A.; Johnson, W. Carter; Guntenspergen, Glenn R.

    2013-01-01

    The Prairie Pothole Region (PPR) of North America is a globally important resource that provides abundant and valuable ecosystem goods and services in the form of biodiversity, groundwater recharge, water purification, flood attenuation, and water and forage for agriculture. Numerous studies have found these wetlands, which number in the millions, to be highly sensitive to climate variability. Here, we compare wetland conditions between two 30-year periods (1946–1975; 1976–2005) using a hindcast simulation approach to determine if recent climate warming in the region has already resulted in changes in wetland condition. Simulations using the WETLANDSCAPE model show that 20th century climate change may have been sufficient to have a significant impact on wetland cover cycling. Modeled wetlands in the PPR's western Canadian prairies show the most dramatic effects: a recent trend toward shorter hydroperiods and less dynamic vegetation cycles, which already may have reduced the productivity of hundreds of wetland-dependent species.

  14. Inner shell coulomb ionization by heavy charged particles studied by the SCA model

    International Nuclear Information System (INIS)

    Hansteen, J.M.

    1976-06-01

    An outline is given of the development of and some achievements hitherto gained from the semi-classical approximation (SCA) model of atomic Coulomb excitation by heavy charged particles. A few very recent results (1975-1976) are incorporated in the discussion. The SCA model has by now reached a mature state. Hence it seems reasonable to regard the atomic Coulomb excitation phenomenon as part of the extremely complicated excitation mechanism operative in the general ion-atom collision. A clear understanding of the complicated X-ray producing mechanisms in heavy-ion-atom collisions is lacking at present. Despite these facts, the conceptually simple SCA model has furthered our understanding far beyond initial expectations. Moreover, this model has at the same time provided a well-founded starting point for continued researches in this rapidly expanding field of physics. (JIW)

  15. Transport and transfer rates in the waters of the continental shelf. Annual report

    International Nuclear Information System (INIS)

    Biscaye, P.E.; Broecker, W.S.; Feely, H.W.; Gerard, R.D.

    1976-04-01

    The report is to the Energy Research and Development Administration on accomplishments of the Lamont-Doherty Geological Observatory geochemistry and physical oceanography groups during the 1975-1976 funding period on grant E(11-1)2185. Goals are to obtain detailed, quantitative knowledge of the rates of mixing within coastal waters of the New York Bight and across the continental slope and the exchange of water masses and species transported within them between shelf and Atlantic Ocean waters. The research is aimed at understanding the chemical, physical, and biological processes which control the origin, dispersal, and fate of particulate matter and trace metals, and to ultimately model the impact of energy related pollutants on the continental shelf

  16. Evidence for 20th century climate warming and wetland drying in the North American Prairie Pothole Region.

    Science.gov (United States)

    Werner, Brett A; Johnson, W Carter; Guntenspergen, Glenn R

    2013-09-01

    The Prairie Pothole Region (PPR) of North America is a globally important resource that provides abundant and valuable ecosystem goods and services in the form of biodiversity, groundwater recharge, water purification, flood attenuation, and water and forage for agriculture. Numerous studies have found these wetlands, which number in the millions, to be highly sensitive to climate variability. Here, we compare wetland conditions between two 30-year periods (1946-1975; 1976-2005) using a hindcast simulation approach to determine if recent climate warming in the region has already resulted in changes in wetland condition. Simulations using the WETLANDSCAPE model show that 20th century climate change may have been sufficient to have a significant impact on wetland cover cycling. Modeled wetlands in the PPR's western Canadian prairies show the most dramatic effects: a recent trend toward shorter hydroperiods and less dynamic vegetation cycles, which already may have reduced the productivity of hundreds of wetland-dependent species.

  17. Comparison of ground-based and Viking Orbiter measurements of Martian water vapor - Variability of the seasonal cycle

    Science.gov (United States)

    Jakosky, B. M.; Barker, E. S.

    1984-01-01

    Earth-based observations of Mars atmospheric water vapor are presented for the 1975-1976, 1977-1978, and 1983 apparitions. Comparisons are made with near-simultaneous spacecraft measurements made from the Viking Orbiter Mars Atmospheric Water Detection experiment during 1976-1978 and with previous earth-based measurements. Differences occur between the behavior in the different years, and may be related to the Mars climate. Measurements during the southern summer in 1969 indicate a factor of three times as much water as is present at this same season in other years. This difference may have resulted from the sublimation of water from the south polar residual cap upon removal of most or all of the CO2 ice present; sublimation of all of the CO2 ice during some years could be a result of a greater thermal load being placed on the cap due to the presence of differing amounts of atmospheric dust.

  18. Value of individual household water supplies in the maintenance phase of a schistosomiasis control programme in Saint-Lucia, after chemotherapy.

    Science.gov (United States)

    Jordan, P; Unrau, G O; Bartholomew, R K; Cook, J A; Grist, E

    1982-01-01

    Between 1970 and 1975, the incidence of new Schistosoma mansoni infections was reduced in 5 villages after each household was provided with its individual water supply and community laundry shower units were made available. In 1975, 1976, and 1977 chemotherapy with oxamniquine was offered to persons found to be infected. Transmission was reduced further and remained at a low level for the next 4 years, with no sign of an increase in spite of the reservoir of infection remaining after therapy and a poor level of sanitation in the villages.Thus, properly maintained water supplies appear to be effective in maintaining transmission at a low level during the maintenance phase of a schistosomiasis control programme, after chemotherapy. Sporadic new infections must be anticipated among children, but these will probably be of low intensity and associated with minimal morbidity.

  19. A comprehensive proteomics study on platelet concentrates: Platelet proteome, storage time and Mirasol pathogen reduction technology.

    Science.gov (United States)

    Salunkhe, Vishal; De Cuyper, Iris M; Papadopoulos, Petros; van der Meer, Pieter F; Daal, Brunette B; Villa-Fajardo, María; de Korte, Dirk; van den Berg, Timo K; Gutiérrez, Laura

    2018-03-19

    Platelet concentrates (PCs) represent a blood transfusion product with a major concern for safety as their storage temperature (20-24°C) allows bacterial growth, and their maximum storage time period (less than a week) precludes complete microbiological testing. Pathogen inactivation technologies (PITs) provide an additional layer of safety to the blood transfusion products from known and unknown pathogens such as bacteria, viruses, and parasites. In this context, PITs, such as Mirasol Pathogen Reduction Technology (PRT), have been developed and are implemented in many countries. However, several studies have shown in vitro that Mirasol PRT induces a certain level of platelet shape change, hyperactivation, basal degranulation, and increased oxidative damage during storage. It has been suggested that Mirasol PRT might accelerate what has been described as the platelet storage lesion (PSL), but supportive molecular signatures have not been obtained. We aimed at dissecting the influence of both variables, that is, Mirasol PRT and storage time, at the proteome level. We present comprehensive proteomics data analysis of Control PCs and PCs treated with Mirasol PRT at storage days 1, 2, 6, and 8. Our workflow was set to perform proteomics analysis using a gel-free and label-free quantification (LFQ) approach. Semi-quantification was based on LFQ signal intensities of identified proteins using MaxQuant/Perseus software platform. Data are available via ProteomeXchange with identifier PXD008119. We identified marginal differences between Mirasol PRT and Control PCs during storage. However, those significant changes at the proteome level were specifically related to the functional aspects previously described to affect platelets upon Mirasol PRT. In addition, the effect of Mirasol PRT on the platelet proteome appeared not to be exclusively due to an accelerated or enhanced PSL. In summary, semi-quantitative proteomics allows to discern between proteome changes due to

  20. Joyce y el inconsciente. // Joyce and the unconscious.

    Directory of Open Access Journals (Sweden)

    Ana Cristina Ramírez Carmen

    2009-12-01

    Full Text Available This paper analyzes two references proposed by Lacan that apparently pose a paradox: in the first reference, in 1975, he stated that Joyce is an unsubscribed from the unconscious; in the second one, in 1976, he affirmed that Unconscious and Real in Joyce are tied one to another, which lead us to ask this question: from which unconscious is Joyce unsubscribed? This way, the author intends to examine the rule of unconscious in Joyce’s case, as explained by Lacan in 1975-1976. If Lacan considers the Unconscious structured like a language to be a lucubration of knowledge in relation with lalangue, this paper will show how Joyce finds a particular answer for the issue of joy that does not pass through that lucubration. // En el presente trabajo se retoman dos referencias de Lacan que plantean una aparente paradoja; en la primera, de 1975, habla de Joyce como desabonado del Inconsciente, en la segunda, en 1976, dice que en Joyce Inconsciente y real se anudan, razón suficiente para preguntarse ¿De qué Inconsciente está desabonado Joyce? Así, se pretende interrogar el estatuto del Inconsciente en el caso de Joyce, tal como lo aborda Lacan en 1975-1976. Si para Lacan el Inconsciente estructurado como un lenguaje es una elucubración de saber sobre lalengua, este recorrido permitirá ver cómo Joyce encuentra una respuesta singular al problema del goce que no pasa por dicha elucubración.

  1. Analysis of organic compounds in industrial and preindustrial ice samples from an Alpine glacier in Switzerland

    Science.gov (United States)

    Holzinger, R.; Schwikowski, M.; Saris, L.

    2013-12-01

    With a newly developed method based on Proton-Transfer-Reaction Mass-Spectrometry (PTR-TOF 8000, Ionicon Inc., Austria) we measured organic compounds in ice samples. We analyzed 8 pre-industrial samples (1738-1747) and 10 post-industrial samples (winter 1975-1976) from the Fiescherhorn Glacier, Switzerland, and 5 firn samples from the Jungfraujoch, Switzerland. Ice cubes made from deionized water (Millipore, 18.2 MΩ.cm @ 25 °C) were used as blank samples. We detected 450 and 138 organic ions that were enhanced in the post-industrial and preindustrial samples, and their total concentration summed up to 24×12 and 3.5×1.8 μgL-1, respectively. The most abundant species in the post-industrial samples were detected at m/z ratios above 200 Da and many of these ions contained nitrogen, while the pre-industrial samples contained lower molecular weight ions (typically below 100 Da) and only a few of them contained nitrogen atoms. If this case study can be extrapolated, our results suggest that human influence significantly enhanced the organic fraction of aerosols since the onset of industrialization (by a factor of ~7). The different chemical composition suggests that the additional organic mass must be due to new sources and chemical pathways. The presented method is a strong tool to constrain organics in the preindustrial atmosphere which may have been very different from conditions prevailing in the remote contemporary atmosphere.Four major ions detected in post-industrial samples (1975/1976) Four major ions detected in pre-industrial samples (1738-1747)

  2. Dosimetric Study of Pelvic Proton Radiotherapy for High-Risk Prostate Cancer

    International Nuclear Information System (INIS)

    Chera, Bhishamjit S.; Vargas, Carlos; Morris, Christopher G.; Louis, Debbie; Flampouri, Stella; Yeung, Daniel; Duvvuri, Srividya; Li Zuofeng; Mendenhall, Nancy Price

    2009-01-01

    Purpose: To compare dose distributions in targeted tissues (prostate, seminal vesicles, pelvic regional nodes) and nontargeted tissues in the pelvis with intensity-modulated radiotherapy (IMRT) and forward-planned, double-scattered, three-dimensional proton radiotherapy (3D-PRT). Methods and Materials: IMRT, IMRT followed by a prostate 3D-PRT boost (IMRT/3D-PRT), and 3D-PRT plans were created for 5 high-risk prostate cancer patients (n = 15 plans). A 78-CGE/Gy dose was prescribed to the prostate and proximal seminal vesicles and a 46-CGE/Gy was prescribed to the pelvic nodes. Various dosimetric endpoints were compared. Results: Target coverage of the prostate and nodal planning target volumes was adequate for all three plans. Compared with the IMRT and IMRT/3D-PRT plans, the 3D-PRT plans reduced the mean dose to the rectum, rectal wall, bladder, bladder wall, small bowel, and pelvis. The relative benefit of 3D-PRT (vs IMRT) at reducing the rectum and rectal wall V5-V40 was 53% to 71% (p < 0.05). For the bladder and bladder wall, the relative benefit for V5 to V40 CGE/Gy was 40% to 63% (p < 0.05). The relative benefit for reducing the volume of small bowel irradiated from 5 to 30 CGE/Gy in the 3D-PRT ranged from 62% to 69% (p < 0.05). Use of 3D-PRT did not produce the typical low-dose 'bath' of radiation to the pelvis seen with IMRT. Femoral head doses were higher for the 3D-PRT. Conclusions: Use of 3D-PRT significantly reduced the dose to normal tissues in the pelvis while maintaining adequate target coverage compared with IMRT or IMRT/3D-PRT. When treating the prostate, seminal vesicles, and pelvic lymph nodes in prostate cancer, proton therapy may improve the therapeutic ratio beyond what is possible with IMRT.

  3. A comparison of efficacy of photoradiation therapy and other conventional treatment modalities on experimental MS-2 sarcoma

    International Nuclear Information System (INIS)

    Pazzoni, Gabriella; Savi, Giuseppina; Melloni, Elsa; Marchesini, Renato; Fava, Giannino; Locati, Lucia; Zunino, Franco

    1984-01-01

    The therapeutic efficacy of photoradiation therapy (PRT) following hematoporthyrin derivative (HpD) administration was compared in the experimental MS-2 tumour model to that of conventional treatment methods for local control of neoplastic diseases (i.e. surgery and radiotherapy). The therapeutic effects of PRT and surgical removal of primary tumour were comparable in these experiments. However, optimal effects were critically dependent on the stage of tumour development. In addition, the therapeutic advantage of PRT over radiotherapy suggests an interesting role of a new approach in tumours resistant to this conventional treatment. (author)

  4. 77 FR 12673 - Approval of Air Quality Implementation Plans; California; South Coast; Attainment Plan for 1997 8...

    Science.gov (United States)

    2012-03-01

    ..., Douglas Ito, Chief, Air Quality and Transportation Planning Branch; California Air Resources Board... District determine compliance with the ``global commitment'' target, thus leaving them in a situation faced... plans, after consultation with the operators adopt ridership increase target for 1983-1987. Emission...

  5. Unauthorized Appropriations and Expiring Authorizations

    Science.gov (United States)

    2015-01-15

    Unauthorized FY 2015 Appropriations: Not Available Organ Donation and Recovery Improvement ActP.L. 108-216 Reimbursement of travel and subsistence...FY 2013 Appropriation Authorized: Indefinite Unauthorized FY 2015 Appropriations: Not Available Capital investment grants to support intercity ...priority rail corridor projects necessary to reduce congestion or facilitate ridership growth in intercity rail passenger transportation * FY 2013

  6. Measuring Passenger Travel Time Reliability Using Smart Card Data

    NARCIS (Netherlands)

    Bagherian, M.; Cats, O.; van Oort, N.; Hickman, M

    2016-01-01

    Service reliability is a key performance measure for transit agencies in increasing their service quality and thus ridership. Conventional reliability metrics are established based on vehicle movements and thus do not adequately reflect passenger’s experience. In the past few years, the growing

  7. 40 CFR 51.493 - State program requirements.

    Science.gov (United States)

    2010-07-01

    ..., the current ridership rates, and the availability and usage of parking facilities. (7) Information... rates. (iii) Mass balance calculations which are a function of inventory, usage, and/or disposal records... support of the SIP submittal, a statistical showing that the specified averaging time is consistent with...

  8. Using the GTFS format to improve public transport data accessibility in Gauteng

    CSIR Research Space (South Africa)

    Koetsier, Sumarie

    2017-10-01

    Full Text Available Public transport plays an important role in cities. It is a less expensive option than private transport and could reduce congestion and improve accessibility to jobs. However, ridership could be hampered when information regarding an operator’s...

  9. Improving public transport decision making, planning and operations by using big data : Cases from Sweden and the Netherlands

    NARCIS (Netherlands)

    Van Oort, N.; Cats, O.

    2015-01-01

    New big data (sources) in the public transport industry enable to deal with major challenges such as elevating efficiency, increasing passenger ridership and satisfaction and facilitate the information flow between service providers and service users. This paper presents two actual cases from the

  10. Train station access and train use: a joint stated and revealed preference choice modelling study

    NARCIS (Netherlands)

    La Paix Puello, Lissy Cesarina; Geurs, Karst Teunis; Geurs, K.T.; Patuelli, R.; Dentinho, T.

    2016-01-01

    Public transport accessibility depends not only on the places and opportunities that can be reached by transit, but also on accessibility to public transport. The characteristics of access and egress modes influence accessibility patterns but also ridership levels of public transport modes. In

  11. Measuring Passenger Travel Time Reliability using Smartcard Data

    NARCIS (Netherlands)

    Bagherian, M.; Cats, O.; van Oort, N.; Hickman, M

    2016-01-01

    Service reliability is a key performance measure for transit agencies in increasing their service quality and thus ridership. Conventional reliability metrics are established based on vehicle movements and thus do not adequately reflect passenger’s experience. In the past few years, the growing

  12. Public transportation research study : price elasticity of rideshare : commuter fringe benefits & parking cash-out

    Science.gov (United States)

    2004-06-01

    The goal of this research project was to determine the price elasticity of rideshare with specific objectives of helping to assess what the effect on ridership would be if the effective price paid by the traveler was substantially reduced (i.e., incr...

  13. Hemostatic function of buffy coat platelets in additive solution treated with pathogen reduction technology

    DEFF Research Database (Denmark)

    Ostrowski, Sisse R; Bochsen, Louise; Windeløv, Nis Agerlin

    2011-01-01

    BACKGROUND: Pathogen reduction technologies (PRTs) may influence the hemostatic potential of stored platelet (PLT) concentrates. To investigate this, buffy coat PLTs (BCPs) stored in PLT additive solution (SSP+) with or without Mirasol PRT treatment (CaridianBCT Biotechnologies) were compared...

  14. 77 FR 49453 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2012-08-16

    ... citations to, and analyses of, the applicable laws and regulations. We will not consider or include in our... period. Applicant: Alexandria Rosati, Cambridge, MA; PRT-72061A The applicant requests a permit to...

  15. Winning the Peace: Institutionalizing Provincial Reconstruction Teams in the United States Military

    Science.gov (United States)

    2012-06-15

    dental and veterinary care; the construction of rudimentary surface transportation systems and public facilities; and...rather than at the tactical unit level. Provided that this change occurs, the entire calculus of the PRT could correspondingly change. Assuming that

  16. Forging Provincial Reconstruction Teams

    National Research Council Canada - National Science Library

    Honore, Russel L; Boslego, David V

    2007-01-01

    The Provincial Reconstruction Team (PRT) training mission completed by First U.S. Army in April 2006 was a joint Service effort to meet a requirement from the combatant commander to support goals in Afghanistan...

  17. 77 FR 66476 - Endangered Species; Marine Mammals; Receipt of Applications for Permit

    Science.gov (United States)

    2012-11-05

    ... Desert, Palm Desert, CA; PRT-88568A The applicant requests a permit to import three jaguars (Panthera... biological samples of black rhinos (Diceros bicornis) to Kruger National Park, Mpumalanga, South Africa, for...

  18. Allogeneic Hematopoietic Stem Cell Transplantation in patients with Acute Myeloid Leukemia : a personalized approach : Allogene hematopoïetische stamcel transplantatie voor patiënten met acute myeloïde leukemie : een gepersonaliseerde benadering

    NARCIS (Netherlands)

    J. Versluis (Jurjen)

    2017-01-01

    textabstractThe majority of patients with newly diagnosed acute myeloid leukemia (AML) obtain complete hematological remission (CR) after induction chemotherapy, but the incidence of relapse is considerable despite chemotherapeutic consolidation therapy. Currently, post-remission treatment (PRT) for

  19. 77 FR 3493 - Endangered Species Receipt of Applications for Permit

    Science.gov (United States)

    2012-01-24

    ..., Moseley, VA; PRT-57466A. The applicant requests a permit to import 6 female captive-born cheetahs (Acinonyx jubatus jubatus) from De Wildt Cheetah Breeding Centre, De Wildt, South Africa for the purpose of...

  20. 76 FR 30386 - Endangered Species; Marine Mammals; Receipt of Applications for Permit

    Science.gov (United States)

    2011-05-25

    ...) Those supported by quantitative information or studies; and (2) Those that include citations to, and.... Applicant: Mary Hunt, Edmore, MI; PRT-42976A The applicant requests a permit to import a sport-hunted trophy...

  1. 78 FR 21627 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2013-04-11

    ... decisions are: (1) Those supported by quantitative information or studies; and (2) Those that include... Tapiridae Applicant: Michael Tomb, Jackson, LA; PRT-01602B The applicant requests a permit to import a sport...

  2. Can palliative radiotherapy influence prostate-specific antigen response in patients with castrate-resistant prostate cancer treated with systemic therapy (chemotherapy or abiraterone)?—a report of three cases

    International Nuclear Information System (INIS)

    Hingorani, Mohan; Dixit, Sanjay; Pugazhenthi, Pattu; Hawkyard, Simon; Robertson, Andrew; Khafagy, Richard

    2015-01-01

    Palliative radiotherapy (pRT) is primarily employed for palliation of bone pain in patients with castrate-resistant prostate cancer (CRPC). However, evidence that pRT influences prostate-specific antigen response in patients with CRPC on systemic therapy is lacking. We describe three cases of CRPC progressing after treatment with docetaxel (n=2) and abiraterone (n=1), who responded unusually after pRT for bone pain with the development of a significant biochemical response and restoration of response to systemic therapy. The possibility of pRT influencing metastatic disease in CRPC has not been previously reported, and raises the possibility of radiation-induced modulation of anti-tumor immune response mechanisms that may play a role in the restoration of response to systemic treatment

  3. Immunosuppression Adherence in Stable Kidney Transplant Patients Converted From Immediate- to Prolonged-Release Tacrolimus in Clinical Practice: A Norwegian Study

    Directory of Open Access Journals (Sweden)

    Sadollah Abedini, MD, PhD

    2018-02-01

    Conclusions. There was disparity between high, patient-perceived and low, actual adherence. Converting stable KTPs from IR-T to PR-T in routine practice did not impact long-term adherence to immunosuppression; renal function remained stable.

  4. 75 FR 14627 - Receipt of Applications for Permit

    Science.gov (United States)

    2010-03-26

    ... Zoological, LLC, Greenwich, CT; PRT-01671A The applicant requests a permit to import a female cheetah (Acrinonyx jubatus) from DeWildt Cheetah Breeding Centre, South Africa where the individual cheetah was...

  5. 77 FR 9687 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2012-02-17

    ... Comment Procedures A. How do I request copies of applications or comment on submitted applications? Send...: James Whipple & Nancy Nunke, Romona, CA; PRT-053952 The applicant requests amendment and renewal of his...

  6. Analysis of patterns of palliative radiotherapy in north west India: A regional cancer center experience

    Directory of Open Access Journals (Sweden)

    Akhil Kapoor

    2015-01-01

    Full Text Available Background: Palliative radiotherapy (PRT is the eventual requirement in 30-50% of all cancer patients. PRT is primarily aimed to relieve pain and prevent/treat collapse or fracture in case of bone metastasis, to reduce edema in patients with cranial metastasis, and to control distressing symptoms of rapid primary growth. An audit of PRT planned in a busy cancer center can help in the characterization of the requirements of the patients and the formulation of institutional policies. Materials and Methods: In total, 516 patients who received PRT in our regional cancer center from January 2012 to December 2012 and whose complete records were available for analysis were selected for this retrospective study. Medical records and radiotherapy files were analyzed to obtain data such as sociodemographic parameters, prescription of PRT, and follow up. Descriptive statistics were evaluated in terms of frequencies and percentages to allow comparisons. Results: Of the 516 patients, 73% patients were male; the median age of the patients receiving PRT was 62 years (range 13-83 years. About 48% ( n = 248 patients received PRT at the primary site while rest (52% were given PRT at the metastatic site. The most common indication of PRT was pain (56.8% cases, followed by cytostatic PRT (19.8% and raised ICT (12.4%. The median dose prescribed was 30 Gy (range 8-36 Gy delivered in 1-12 fractions over the duration of 1-18 days. The overall response rate was about 43% at 2 weeks of completion of PRT; the median follow-up of the patients was 154 days (range 9-256 days. The long-term symptom relief at median follow up was 8%. Conclusions: Good clinical judgment and expertise is required in prescribing correct fractionation schedule to achieve effective symptom palliation with lowest possible cost and inconvenience to the patients and relatives. Hypofractionated radiotherapy is a feasible treatment option in patients with advanced incurable disease to achieve effective

  7. Impact of Preoperative Radiotherapy on General and Disease-Specific Health Status of Rectal Cancer Survivors: A Population-Based Study

    International Nuclear Information System (INIS)

    Thong, Melissa S.Y.; Mols, Floortje; Lemmens, Valery E.P.P.; Rutten, Harm J.T.; Roukema, Jan A.; Martijn, Hendrik; Poll-Franse, Lonneke V. van de

    2011-01-01

    Purpose: To date, few studies have evaluated the impact of preoperative radiotherapy (pRT) on long-term health status of rectal cancer survivors. Using a population-based sample, we assessed the impact of pRT on general and disease-specific health status of rectal cancer survivors up to 10 years postdiagnosis. The health status of older (≥75 years old at diagnosis) pRT survivors was also compared with that of younger survivors. Methods and Materials: Survivors identified from the Eindhoven Cancer Registry treated with surgery only (SU) or with pRT between 1998 and 2007 were included. Survivors completed the Short Form-36 (SF-36) health survey questionnaire and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal 38 (EORTC QLQ-CR38) questionnaire. The SF-36 and EORTC QLQ-CR38 (sexuality subscale) scores of the survivors were compared to an age- and sex-matched Dutch normal population. Results: A total of 340 survivors (response, 85%; pRT survivors, 71%) were analyzed. Overall, survivors had similar general health status. Both short-term (<5 years) and long-term (≥5 years) pRT survivors had significantly poorer body image and more problems with gastrointestinal function, male sexual dysfunction, and defecation than SU survivors. Survivors had comparable general health status but greater sexual dysfunction than the normal population. Older pRT survivors had general and disease-specific health status comparable to that of younger pRT survivors. Conclusions: For better survivorship care, rectal cancer survivors could benefit from increased clinical and psychological focus on the possible long-term morbidity of treatment and its effects on health status.

  8. Special Inspector General for Iraq Reconstruction, Report to Congress, October 30, 2006

    Science.gov (United States)

    2006-10-30

    challenges have limited the teaching , coaching, and mentoring that form the core of the PRT capacity-development mission. PRT members are at particular...es p o n si b ili ti es . A s n ec es sa ry , th e M O A s h o u ld b e u p d at ed s o t h at it ac cu ra te ly r efl ec ts t h e b u

  9. Special Inspector General for Iraq Reconstruction (SIGIR): The Year of Transition Enters the Fourth Quarter

    Science.gov (United States)

    2006-10-30

    have limited the teaching , coaching, and mentoring that form the core of the PRT capacity-development mission. PRT members are at particular risk when...si b ili ti es . A s n ec es sa ry , th e M O A s h o u ld b e u p d at ed s o t h at it ac cu ra te ly r efl ec ts t h e b u si n es

  10. Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals - the Swiss HIV Cohort Study

    Directory of Open Access Journals (Sweden)

    Martinetti Gladys

    2011-01-01

    Full Text Available Abstract Background Replicative phenotypic HIV resistance testing (rPRT uses recombinant infectious virus to measure viral replication in the presence of antiretroviral drugs. Due to its high sensitivity of detection of viral minorities and its dissecting power for complex viral resistance patterns and mixed virus populations rPRT might help to improve HIV resistance diagnostics, particularly for patients with multiple drug failures. The aim was to investigate whether the addition of rPRT to genotypic resistance testing (GRT compared to GRT alone is beneficial for obtaining a virological response in heavily pre-treated HIV-infected patients. Methods Patients with resistance tests between 2002 and 2006 were followed within the Swiss HIV Cohort Study (SHCS. We assessed patients' virological success after their antiretroviral therapy was switched following resistance testing. Multilevel logistic regression models with SHCS centre as a random effect were used to investigate the association between the type of resistance test and virological response (HIV-1 RNA Results Of 1158 individuals with resistance tests 221 with GRT+rPRT and 937 with GRT were eligible for analysis. Overall virological response rates were 85.1% for GRT+rPRT and 81.4% for GRT. In the subgroup of patients with >2 previous failures, the odds ratio (OR for virological response of GRT+rPRT compared to GRT was 1.45 (95% CI 1.00-2.09. Multivariate analyses indicate a significant improvement with GRT+rPRT compared to GRT alone (OR 1.68, 95% CI 1.31-2.15. Conclusions In heavily pre-treated patients rPRT-based resistance information adds benefit, contributing to a higher rate of treatment success.

  11. Hubble Space Telescope EVA Power Ratchet Tool redesign

    Science.gov (United States)

    Richards, Paul W.; Park, Chan; Brown, Lee

    The Power Ratchet Tool (PRT) is a self contained, power-driven, 3/8 inch drive ratchet wrench which will be used by astronauts during Extravehicular Activities (EVA). This battery-powered tool is controlled by a dedicated electonic controller. The PRT was flown during the Hubble Space Telescope (HST) Deployment Mission STS-31 to deploy the solar arrays if the automatic mechanisms failed. The PRT is currently intended for use during the first HST Servicing Mission STS-61 as a general purpose power tool. The PRT consists of three major components; the wrench, the controller, and the battery module. Fourteen discrete combinations of torque, turns, and speed may be programmed into the controller before the EVA. The crewmember selects the desired parameter profile by a switch mounted on the controller. The tool may also be used in the manual mode as a non-powered ratchet wrench. The power is provided by a silver-zinc battery module, which fits into the controller and is replaceable during an EVA. The original PRT did not meet the design specification of torque output and hours of operation. To increase efficiency and reliability the PRT underwent a redesign effort. The majority of this effort focused on the wrench. The original PRT drive train consisted of a low torque, high speed brushless DC motor, a face gear set, and a planocentric gear assembly. The total gear reduction was 300:1. The new PRT wrench consists of a low speed, high torque brushless DC motor, two planetary gear sets and a bevel gear set. The total gear reduction is now 75:1. A spline clutch has also been added to disengage the drive train in the manual mode. The design changes to the controller will consist of only those modifications necessary to accomodate the redesigned wrench.

  12. Interaction of hyperthermia and photoradiation therapy

    International Nuclear Information System (INIS)

    Waldow, S.M.; Dougherty, T.J.

    1984-01-01

    Local microwave hyperthermia (2450 MHz) was applied to auxillary implants of the SMT-F mammary carcinoma in mice in combination with photoradiation therapy (PRT) in an attempt to determine if the two modalities interact. When 40.5 0 C was applied for 30 min immediately prior to or immediately following PRT enhancement of tumor response over that of PRT alone was seen as judged by lack of tumor regrowth (35 days or longer after treatment). A temperature of 41.5 0 C applied for 30 min immediately following the 30-min PRT treatment produced a result slightly greater than that seen at 40.5 0 C. When a temperature of 44.5 0 C for 30 min was applied immediately following PRT, a substantial enhancement of tumor control at 35 days post-treatment was found. These results suggest that tumor response to PRT is enhanced by both a sublethal hyperthermic treatment (40.5 0 C, 41.5 0 C) and a moderately lethal heat treatment (44.5 0 C) given for a short duration, when applied immediately before or after photoradiation

  13. Study of Variable Turbulent Prandtl Number Model for Heat Transfer to Supercritical Fluids in Vertical Tubes

    Science.gov (United States)

    Tian, Ran; Dai, Xiaoye; Wang, Dabiao; Shi, Lin

    2018-06-01

    In order to improve the prediction performance of the numerical simulations for heat transfer of supercritical pressure fluids, a variable turbulent Prandtl number (Prt) model for vertical upward flow at supercritical pressures was developed in this study. The effects of Prt on the numerical simulation were analyzed, especially for the heat transfer deterioration conditions. Based on the analyses, the turbulent Prandtl number was modeled as a function of the turbulent viscosity ratio and molecular Prandtl number. The model was evaluated using experimental heat transfer data of CO2, water and Freon. The wall temperatures, including the heat transfer deterioration cases, were more accurately predicted by this model than by traditional numerical calculations with a constant Prt. By analyzing the predicted results with and without the variable Prt model, it was found that the predicted velocity distribution and turbulent mixing characteristics with the variable Prt model are quite different from that predicted by a constant Prt. When heat transfer deterioration occurs, the radial velocity profile deviates from the log-law profile and the restrained turbulent mixing then leads to the deteriorated heat transfer.

  14. The effect of trigger point management by positional release therapy on tension type headache.

    Science.gov (United States)

    Ghanbari, Ali; Rahimijaberi, Abbas; Mohamadi, Marzieh; Abbasi, Leila; Sarvestani, Fahimeh Kamali

    2012-01-01

    The aim of this study was to compare the effectiveness of trigger points' management by Positional Release Therapy (PRT) and routine medical therapy in treatment of Tension Type Headache. Tension Type Headache is the most frequent headache with the basis of myofascial and trigger point disorders. PRT is an indirect technique that treats trigger points. 30 Patients with active trigger points in cervical muscles entered to the study. They were randomly assigned to PRT or medical therapy group. Headache frequency, intensity and duration and tablet count were recorded by use of a daily headache diary. Sensitivity of trigger points was assessed by numeric pain intensity and by use of a digital force gauge (FG 5020). Both groups showed significant reduction in headache frequency and duration and tablet count after treatment phase. However, the reduction of study variables was persisted only in PRT group after follow up phase. There was no significant reduction in headache intensity, neither in PRT and nor in medication group. Sensitivity of trigger points was significantly reduced. In comparison of the two study groups, there was no significant difference in headache frequency, intensity, duration and tablet count (p> 0.05). Both procedures were equally effective according to the study. Thus, PRT can be a treatment choice for patients with T.T.H.

  15. Whole blood pathogen reduction technology and blood safety in sub-Saharan Africa: A systematic review with regional discussion.

    Science.gov (United States)

    Nkohkwo, Asa'ah; Agbor, Gabriel; Asongalem, Emmanuel; Tagny, Claude; Asonganyi, Tazoacha

    2016-01-01

    Despite vast improvements in transfusion services in sub-Saharan Africa over the last decade, there remain serious concerns on the safety and adequacy of the blood supply across the region. This review paper ascertains the role of pathogen reduction technology (PRT) in improving blood safety and supply adequacy in the region. The state of blood safety in sub-Saharan Africa was reviewed. Meetings, seminars and correspondence were undertaken with key clinicians, scientists and professional bodies in the region, including the World Health Organization's Regional Office for Africa, to examine the suitability of PRT for improving the safety of whole blood transfusion, a prevalent transfusion format in the region. Existing literature suggests that combining PRT with current blood safety measures (such as serology) would improve the safety and adequacy of the blood supply for transfusions in sub-Saharan Africa. This was echoed by the findings of the stakeholder meetings. Following a detailed appraisal of two leading PRT systems, the Mirasol ® PRT System and the Cerus S-303 System, we suggest that companies conduct comprehensive toxicological evaluation of the agents used for PRT and publish this in the scientific literature. We also recommend that the safety and efficacy of these technologies should be established in a randomised clinical trial conducted in sub-Saharan Africa.

  16. Photobiology of porphyrins

    International Nuclear Information System (INIS)

    Gomer, C.J.

    1984-01-01

    Hematoporphyrin derivative (HpD) photoradiation therapy (PRT) continues to show promise as a modality for the treatment of certain solid tumors. However, there are still numerous photobiological parameters pertaining to HpD PRT which are not fully defined. This presentation describes preclinical studies performed to examine the efficacy of HpD PRT for the treatment of ocular tumors. In addition, results of photobiological experiments designed to define the action spectrum characteristics, light dose rate properties and mutagenic potential of HpD PRT are discussed. Preclinical studies have examined the pharmacology of HpD and the toxicology of HpD PRT in both normal and malignant structures in the eye of pigmented rabbits. Distribution of HpD was measured by an acid extraction procedure. Vascular structures of the eye such as the choroid, iris and the experimental tumor retained significant levels of HpD following I.V. administration. Non-vascular structures such as cornea and lens did not take up HpD. Toxicity studies demonstrated that HpD administration (1-10 mg/kg) followed 48 hr later with a transpupil irradiation of red light (630 nm, 40-90 J/cm/sup 2/) resulted in well defined areas of retinal damage within the treatment field. The lenses of 18 eyes have remained clear during a 24 month follow-up. Tumor response following HpD PRT is rapid and is characterized by massive vascular disruption and tumor tissue necrosis

  17. Characterization of the mature cell surface proteinase of Lactobacillus delbrueckii subsp. lactis CRL 581.

    Science.gov (United States)

    Villegas, Josefina M; Brown, Lucía; Savoy de Giori, Graciela; Hebert, Elvira M

    2015-05-01

    The cell envelope-associated proteinase (CEP) of Lactobacillus delbrueckii subsp. lactis CRL 581 (PrtL) has an essential role in bacterial growth, contributes to the flavor and texture development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. The genome of L. delbrueckii subsp. lactis CRL 581 possesses only one gene that encodes PrtL, which consists of 1924 amino acids and is a multidomain protein anchored to the cell via its W domain. PrtL was extracted from the cell under high ionic strength conditions using NaCl, suggesting an electrostatic interaction between the proteinase and the cell envelope. The released PrtL was purified and biochemically characterized; its activity was maximal at temperatures between 37 and 40 °C and at pH between 7 and 8. Under optimal conditions, PrtL exhibited higher affinity for succinyl-alanyl-alanyl-prolyl-phenylalanine-p-nitroanilide than for succinyl-alanyl-glutamyl-prolyl-phenylalanine-p-nitroanilide, while methoxy-succinyl-arginyl-prolyl-tyrosyl-p-nitroanilide was not degraded. A similar α- and β-casein degradation pattern was observed with the purified and the cell envelope-bound proteinase. Finally, on the basis of its specificity towards caseins and the unique combination of amino acids at residues thought to be involved in substrate specificity, PrtL can be classified as a representative of a new group of CEP.

  18. The feasibility of progressive resistance training in women with polycystic ovary syndrome: a pilot randomized controlled trial.

    Science.gov (United States)

    Vizza, Lisa; Smith, Caroline A; Swaraj, Soji; Agho, Kingsley; Cheema, Birinder S

    2016-01-01

    To evaluate the feasibility of executing a randomized controlled trial of progressive resistance training (PRT) in women with polycystic ovary syndrome (PCOS). Women with PCOS were randomized to an experimental (PRT) group or a no-exercise (usual care) control group. The PRT group was prescribed two supervised and two unsupervised (home-based) training sessions per week for 12 weeks. Feasibility outcomes included recruitment and attrition, adherence, adverse events, and completion of assessments. Secondary outcomes, collected pre and post intervention, included a range of pertinent physiological, functional and psychological measures. Fifteen participants were randomised into the PRT group (n = 8) or control group (n = 7); five women (n = 2 in PRT group and n = 3 in control group) withdrew from the study. The most successful recruitment sources were Facebook (40 %) and online advertisement (27 %), while least successful methods were referrals by clinicians, colleagues and flyers. In the PRT group, attendance to supervised sessions was higher (95 %; standard deviation ±6 %) compared to unsupervised sessions (51 %; standard deviation ±28 %). No adverse events were attributed to PRT. Change in menstrual cycle status was not significantly different between groups over time (p = 0.503). However, the PRT group significantly increased body weight (p = 0.01), BMI (p = 0.04), lean mass (p = 0.01), fat-free mass (p = 0.005) and lower body strength (p = 0.03), while reducing waist circumference (p = 0.03) and HbA1c (p = 0.033) versus the control group. The PRT group also significantly improved across several domains of disease-specific and general health-related quality of life, depression, anxiety and exercise self-efficacy. A randomized controlled trial of PRT in PCOS would be feasible, and this mode of exercise may elicit a therapeutic effect on clinically important outcomes in this cohort. The success of a large

  19. A Population-based Study of the Fractionation of Palliative Radiotherapy for Bone Metastasis in Ontario

    International Nuclear Information System (INIS)

    Kong, Weidong; Zhang-Salomons, Jina; Hanna, Timothy P.; Mackillop, William J.

    2007-01-01

    Purpose: To describe the use of palliative radiotherapy (PRT) for bone metastases in Ontario between 1984 and 2001 and identify factors associated with the choice of fractionation. Methods and Materials: Electronic RT records from the nine provincial RT centers in Ontario were linked to the Ontario Cancer Registry to identify all courses of PRT for bone metastases. Results: Between 1984 and 2001, 44,884 patients received 74,432 courses of PRT for bone metastases in Ontario. The mean number of courses per patient was 1.7, and 65% of patients received only a single course of PRT for bone metastasis. The mean number of fractions per course was 3.9. The proportion of patients treated with a single fraction increased from 27.2% in 1984-1986 to 40.3% in 1987-1992 and decreased thereafter. Single fractions were used more frequently in patients with a shorter life expectancy, in older patients, and in patients who lived further from an RT center. Single fractions were used more frequently when the prevailing waiting time for RT was longer. There were wide variations in the use of single fractions among the different RT centers (intercenter range, 11.8-62.3%). Intercenter variations persisted throughout the study period and were not explained by differences in case mix. Conclusions: Despite increasing evidence of the effectiveness of single-fraction PRT for bone metastases, most patients continued to receive fractionated PRT throughout the two decades of this study. Single fractions were used more frequently when waiting times were longer. There was persistent, unexplained variation in the fractionation of PRT among different centers

  20. Resistance Exercise Impacts Lean Muscle Mass in Women with Polycystic Ovary Syndrome.

    Science.gov (United States)

    Kogure, Gislaine Satyko; Miranda-Furtado, Cristiana Libardi; Silva, Rafael Costa; Melo, Anderson Sanches; Ferriani, Rui Alberto; De Sá, Marcos Felipe Silva; Dos Reis, Rosana Maria

    2016-04-01

    This study investigated the effects of progressive resistance training (PRT) on lean muscle mass (LMM) in women with or without polycystic ovary syndrome (PCOS) and its effects on metabolic factors and concentrations of related steroid hormones. This was a nonrandomized, therapeutic, open, single-arm study. All in all, 45 sedentary women with PCOS and 52 without (non-PCOS), 18-37 yr of age, with body mass indexes (BMI) of 18-39.9 kg·m(-2) of all races and social status, performed PRT three times a week for 4 months. Before and after PRT, the concentrations of hormones and metabolic factors and waist circumference were measured. LMM and total body fat percentage were determined using dual-energy x-ray absorptiometry. Clinical characteristics, LMM, and fasting glucose were adjusted for confounding covariables and compared using general linear mixed models. Each patient's menstrual history was taken before study enrollment and after PRT. PRT resulted in reduced plasma testosterone and fasting glucose levels. After PRT, the androstenedione concentration increased and the sex hormone-binding globulin concentration decreased in women with PCOS. The waist circumference was reduced (P lean mass (LM)/height2, increased in women with PCOS (P = 0.04). Women with PCOS showed increased muscle mass indexes of appendicular LM/height2 (P = 0.03) and LM/height2 (P women with PCOS (P = 0.01) at the baseline and after PRT. To our knowledge, this is the first report to show that resistance exercise alone can improve hyperandrogenism, reproductive function, and body composition by decreasing visceral fat and increasing LMM, but it has no metabolic impact on women with PCOS.

  1. Deep-Sea Trench Microbiology Down to 10.9 Kilometers Below the Surface

    Science.gov (United States)

    Bartlett, D. H.

    2012-12-01

    Deep-sea trenches, extending to more than 10.9 km below the sea surface, are among the most remote and infrequently sampled habitats. As a result a global perspective of microbial diversity and adaptation is lacking in these extreme settings. I will present the results of studies of deep-sea trench microbes collected in the Puerto Rico Trench (PRT), Tonga Trench, New Britain Trench and Mariana Trench. The samples collected include sediment, seawater and animals in baited traps. The analyses to be described include microbial community activity and viability measurements as a function of hydrostatic pressure, microbial culturing at high pressure under various physiological conditions, phylogenetics and metagenome and single-cell genome characterizations. Most of the results to date stem from samples recovered from the PRT. The deep-sea PRT Trench microbes have more in common at the species level with other deep-sea microbial communities previously characterized in the Pacific Ocean and the Mediterranean Sea than with the microbial populations above them in shallow waters. They also harbor larger genomes with more genes assigned to signal transduction, transcription, replication, recombination and repair and inorganic ion transport. The overrepresented transporters in the PRT metagenome include di- and tri-carboxylate transporters that correspond to the prevailing catabolic processes such as butanoate, glyoxylate and dicarboxylate metabolism. A surprisingly high abundance of sulfatases for the degradation of sulfated polysaccharides were also present in the PRT. But, perhaps the most dramatic adaptational feature of the PRT microbes is heavy metal resistance, as reflected in the high numbers of metal efflux systems present. Single-cell genomics approaches have proven particularly useful for placing PRT metagenomic data into context.

  2. Proton Radiation Therapy for the Treatment of Retinoblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Mouw, Kent W. [Harvard Radiation Oncology Program, Boston, Massachusetts (United States); Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Sethi, Roshan V.; Yeap, Beow Y.; MacDonald, Shannon M.; Chen, Yen-Lin E.; Tarbell, Nancy J.; Yock, Torunn I.; Munzenrider, John E.; Adams, Judith [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Grabowski, Eric [Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts (United States); Mukai, Shizuo [Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts (United States); Shih, Helen A., E-mail: hshih@partners.org [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2014-11-15

    Purpose: To investigate long-term disease and toxicity outcomes for pediatric retinoblastoma patients treated with proton radiation therapy (PRT). Methods and Materials: This is a retrospective analysis of 49 retinoblastoma patients (60 eyes) treated with PRT between 1986 and 2012. Results: The majority (84%) of patients had bilateral disease, and nearly half (45%) had received prior chemotherapy. At a median follow-up of 8 years (range, 1-24 years), no patients died of retinoblastoma or developed metastatic disease. The post-PRT enucleation rate was low (18%), especially in patients with early-stage disease (11% for patients with International Classification for Intraocular Retinoblastoma [ICIR] stage A-B disease vs 23% for patients with ICIR stage C-D disease). Post-PRT ophthalmologic follow-up was available for 61% of the preserved eyes (30 of 49): 14 of 30 eyes (47%) had 20/40 visual acuity or better, 7 of 30 (23%) had moderate visual acuity (20/40-20/600), and 9 of 30 (30%) had little or no useful vision (worse than 20/600). Twelve of 60 treated eyes (20%) experienced a post-PRT event requiring intervention, with cataracts the most common (4 eyes). No patients developed an in-field second malignancy. Conclusions: Long-term follow-up of retinoblastoma patients treated with PRT demonstrates that PRT can achieve high local control rates, even in advanced cases, and many patients retain useful vision in the treated eye. Treatment-related ocular side effects were uncommon, and no radiation-associated malignancies were observed.

  3. United States Army physical readiness training: rationale and evaluation of the physical training doctrine.

    Science.gov (United States)

    Knapik, Joseph J; Rieger, William; Palkoska, Frank; Van Camp, Steven; Darakjy, Salima

    2009-07-01

    This paper reviews the rationale and evaluations of Physical Readiness Training (PRT), the new U.S. Army physical training doctrine designed to improve soldiers' physical capability for military operations. The purposes of PRT are to improve physical fitness, prevent injuries, progressively train soldiers, and develop soldiers' self-confidence and discipline. The PRT follows the principles of progressive overload, regularity, specificity, precision, variety, and balance. Specificity was achieved by examining the standard list of military (warrior) tasks and determining 1) the physical requirements, 2) the fitness components involved, and 3) the training activities that most likely could improve the military tasks. Injury-prevention features include reduced running mileage, exercise variety (cross-training), and gradual, progressive training. In 3 military field studies, the overall adjusted risk of injury was 1.5-1.8 times higher in groups of soldiers performing traditional military physical training programs when compared with groups using a PRT program. Scores on the Army Physical Fitness Test were similar or higher in groups using PRT programs. In an 8-week laboratory study comparing PRT with a weightlifting/running program, both programs resulted in major improvements in militarily relevant tasks (e.g., 3.2-km walk/run with 32-kg load, 400-m run with 18-kg load, 5- to 30-second rushes to and from prone position, 80-kg casualty drag, obstacle course). When compared with traditional military physical training programs, PRT consistently resulted in fewer injuries and in equal or greater improvements in fitness and military task performance.

  4. Riboflavin and ultraviolet light for pathogen reduction of murine cytomegalovirus in blood products.

    Science.gov (United States)

    Keil, Shawn D; Saakadze, Natia; Bowen, Richard; Newman, James L; Karatela, Sulaiman; Gordy, Paul; Marschner, Susanne; Roback, John; Hillyer, Christopher D

    2015-04-01

    Two studies were performed to test the effectiveness of riboflavin and ultraviolet (UV) light treatment (Mirasol PRT, Terumo BCT) against murine cytomegalovirus (MCMV). The first study utilized immune-compromised mice to measure the reduction of cell-free MCMV. A second study used a murine model to evaluate the ability of Mirasol PRT to prevent transfusion-transmitted (TT)-MCMV infection. Human plasma was inoculated with MCMV and then treated with Mirasol PRT. The viral titer was measured using an infectious dose 50% assay in nude mice. Mice were euthanized on Day 10 posttransfusion, and their spleens were tested for the presence of MCMV DNA using polymerase chain reaction (PCR). Mirasol PRT was also evaluated to determine its effectiveness in preventing TT-MCMV in platelets (PLTs) stored in PLT additive solution. PLTs were inoculated with either cell-associated MCMV or cell-free MCMV and then treated with Mirasol PRT. Mice were transfused with treated or untreated product and were euthanized 14 days posttransfusion. Blood and spleens were assayed for MCMV DNA by real-time-PCR. Using nude mice to titer MCMV, a modest 2.1-log reduction was observed in plasma products after Mirasol PRT treatment. TT-MCMV was not observed in the mouse transfusion model when either cell-free or cell-associated MCMV was treated with Mirasol PRT; MCMV transmission was uniformly observed in mice transfused with untreated PLTs. These results suggest that using riboflavin and UV light treatment may be able to reduce the occurrence of transmission of human CMV from infectious PLTs and plasma units. © 2014 AABB.

  5. Qualifications of Bonding Process of Temperature Sensors to Deep-Space Missions

    Science.gov (United States)

    Ramesham, Rajeshuni; Kitiyakara, Amarit; Redick, Richard W., III; Sunada, Eric T.

    2011-01-01

    A process has been examined for bonding a platinum resistance thermometer (PRT) onto potential aerospace materials such as flat aluminum surfaces and a flexible copper tube to simulate coaxial cables for flight applications. Primarily, PRTs were inserted into a silver-plated copper braid to avoid stresses on the sensor while the sensor was attached with the braid to the base material for long-duration, deep-space missions. A1-1145/graphite composite (planar substrate) and copper tube have been used in this study to assess the reliability of PRT bonding materials. A flexible copper tube was chosen to simulate the coaxial cable to attach PRTs. The substrate materials were cleaned with acetone wipes to remove oils and contaminants. Later, the surface was also cleaned with ethyl alcohol and was air-dried. The materials were gently abraded and then were cleaned again the same way as previously mentioned. Initially, shielded (silver plated copper braid) PRT (type X) test articles were fabricated and cleaned. The base antenna material was pretreated and shielded, and CV-2566 NuSil silicone was used to attach the shielded PRT to the base material. The test articles were cured at room temperature and humidity for seven days. The resistance of the PRTs was continuously monitored during the thermal cycling, and the test articles were inspected prior to, at various intermediate steps during, and at the end of the thermal cycling as well. All of the PRTs survived three times the expected mission life for the JUNO project. No adhesion problems were observed in the PRT sensor area, or under the shielded PRT. Furthermore, the PRT resistance accurately tracked the thermal cycling of the chamber.

  6. Modeling and evaluation of characteristics for on-street Rapid Transit systems

    DEFF Research Database (Denmark)

    Andersen, Jonas Lohmann Elkjær; Landex, Alex

    2012-01-01

    to obtain the main objective of introducing a Rapid Transit System. to increase the number of passengers. Variations in the system characteristics have a direct impact on ridership. However, it is difficult to predict the impact of implementing or altering the characteristics. A Rapid Transit system should...... display sufficient service already in the planning phase. That is why pre-acquired knowledge of the impact of the characteristics on the system performance is valuable. Such knowledge could provide a firm basis for planning the service and operation of a Rapid Transit system. This article focuses....... It focuses on the following characteristics for Rapid Transit systems: rail factor, travel time, headway and capacity. It evaluates how the implementation and variation of these characteristics affected the ridership of a case project. It evaluates the magnitude of the impacts for the various characteristics...

  7. Transit Use, Physical Activity, and Body Mass Index Changes: Objective Measures Associated With Complete Street Light-Rail Construction

    Science.gov (United States)

    Werner, Carol M.; Tribby, Calvin P.; Miller, Harvey J.; Smith, Ken R.

    2015-01-01

    Objectives. We assessed effects on physical activity (PA) and weight among participants in a complete street intervention that extended a light-rail line in Salt Lake City, Utah. Methods. Participants in the Moving Across Places Study resided within 2 kilometers of the new line. They wore accelerometers and global positioning system (GPS) loggers for 1 week before and after rail construction. Regression analyses compared change scores of participants who never rode transit with continuing, former, and new riders, after adjustment for control variables (total n = 537). Results. New riders had significantly more accelerometer-measured counts per minute than never-riders (P transit ridership in the complete street area, research should address how to encourage more sustained ridership. PMID:25973829

  8. Results of the Fall 2007 UC Davis Campus Travel Assessment

    OpenAIRE

    Congleton, Christopher

    2009-01-01

    Our collective transportation choices have far-reaching effects both locally and globally, from traffic congestion to global warming. While the concerted actions of many travelers working together could make significant inroads into solving these problems, a single traveler working alone could not. This report presents a snapshot of campus travel at the outset of the 2007-2008 academic year, measures campus mode split and average vehicle ridership, collects UC Davis travelers' opinions about ...

  9. Transportation assimilation revisited: New evidence from repeated cross-sectional survey data

    Science.gov (United States)

    2018-01-01

    Background Based on single cross-sectional data, prior research finds evidence of “transportation assimilation” among U.S. immigrants: the length of stay in the U.S. is negatively correlated with public transit use. This paper revisits this question by using repeated cross-sectional data, and examines the trend of transportation assimilation over time. Methods and results Using 1980, 1990, 2000 1% census and 2010 (1%) American Community Survey, I examine the relationship between the length of stay in the U.S. and public transit ridership among immigrants. I first run regressions separately in four data sets: I regress public transit ridership on the length of stay, controlling for other individual and geographic variables. I then compare the magnitudes of the relationship in four regressions. To study how the rate of transportation assimilation changes over time, I pool the data set and regress public transit ridership on the length of stay and its interactions with year dummies to compare the coefficients across surveys. Results confirm the conclusion of transportation assimilation: as the length of stay in the U.S. increases, an immigrant’s public transit use decreases. However, the repeated cross-section analysis suggests the assimilation rate has been decreasing in the past few decades. Conclusions This paper finds evidence of transportation assimilation: immigrants become less likely to ride public transit as the length of stay in the U.S. increases. The assimilation rate, however, has been decreasing over time. This paper finds that the rate of public transit ridership among new immigrants upon arrival, the geographic distribution of immigrants, and the changing demographics of the U.S. immigrants play roles in affecting the trend of transportation assimilation. PMID:29668676

  10. The FasX Small Regulatory RNA Negatively Regulates the Expression of Two Fibronectin-Binding Proteins in Group A Streptococcus.

    Science.gov (United States)

    Danger, Jessica L; Makthal, Nishanth; Kumaraswami, Muthiah; Sumby, Paul

    2015-12-01

    The group A Streptococcus (GAS; Streptococcus pyogenes) causes more than 700 million human infections each year. The success of this pathogen can be traced in part to the extensive arsenal of virulence factors that are available for expression in temporally and spatially specific manners. To modify the expression of these virulence factors, GAS use both protein- and RNA-based regulators, with the best-characterized RNA-based regulator being the small regulatory RNA (sRNA) FasX. FasX is a 205-nucleotide sRNA that contributes to GAS virulence by enhancing the expression of the thrombolytic secreted virulence factor streptokinase and by repressing the expression of the collagen-binding cell surface pili. Here, we have expanded the FasX regulon, showing that this sRNA also negatively regulates the expression of the adhesion- and internalization-promoting, fibronectin-binding proteins PrtF1 and PrtF2. FasX posttranscriptionally regulates the expression of PrtF1/2 through a mechanism that involves base pairing to the prtF1 and prtF2 mRNAs within their 5' untranslated regions, overlapping the mRNA ribosome-binding sites. Thus, duplex formation between FasX and the prtF1 and prtF2 mRNAs blocks ribosome access, leading to an inhibition of mRNA translation. Given that FasX positively regulates the expression of the spreading factor streptokinase and negatively regulates the expression of the collagen-binding pili and of the fibronectin-binding PrtF1/2, our data are consistent with FasX functioning as a molecular switch that governs the transition of GAS between the colonization and dissemination stages of infection. More than half a million deaths each year are a consequence of infections caused by GAS. Insights into how this pathogen regulates the production of proteins during infection may facilitate the development of novel therapeutic or preventative regimens aimed at inhibiting this activity. Here, we have expanded insight into the regulatory activity of the GAS small

  11. Selective albumin-binding surfaces modified with a thrombin-inhibiting peptide.

    Science.gov (United States)

    Freitas, Sidónio C; Maia, Sílvia; Figueiredo, Ana C; Gomes, Paula; Pereira, Pedro J B; Barbosa, Mário A; Martins, M Cristina L

    2014-03-01

    Blood-contacting medical devices have been associated with severe clinical complications, such as thrombus formation, triggered by the activation of the coagulation cascade due to the adsorption of certain plasma proteins on the surface of biomaterials. Hence, the coating of such surfaces with antithrombotic agents has been used to increase biomaterial haemocompatibility. Biomaterial-induced clotting may also be decreased by albumin adsorption from blood plasma in a selective and reversible way, since this protein is not involved in the coagulation cascade. In this context, this paper reports that the immobilization of the thrombin inhibitor D-Phe-Pro-D-Arg-D-Thr-CONH2 (fPrt) onto nanostructured surfaces induces selective and reversible adsorption of albumin, delaying the clotting time when compared to peptide-free surfaces. fPrt, synthesized with two glycine residues attached to the N-terminus (GGfPrt), was covalently immobilized onto self-assembled monolayers (SAMs) having different ratios of carboxylate-hexa(ethylene glycol)- and tri(ethylene glycol)-terminated thiols (EG6-COOH/EG3) that were specifically designed to control GGfPrt orientation, exposure and density at the molecular level. In solution, GGfPrt was able to inactivate the enzymatic activity of thrombin and to delay plasma clotting time in a concentration-dependent way. After surface immobilization, and independently of its concentration, GGfPrt lost its selectivity to thrombin and its capacity to inhibit thrombin enzymatic activity against the chromogenic substrate n-p-tosyl-Gly-Pro-Arg-p-nitroanilide. Nevertheless, surfaces with low concentrations of GGfPrt could delay the capacity of adsorbed thrombin to cleave fibrinogen. In contrast, GGfPrt immobilized in high concentrations was found to induce the procoagulant activity of the adsorbed thrombin. However, all surfaces containing GGfPrt have a plasma clotting time similar to the negative control (empty polystyrene wells), showing resistance to

  12. Concurrent transcranial direct current stimulation and progressive resistance training in Parkinson's disease: study protocol for a randomised controlled trial.

    Science.gov (United States)

    Hendy, Ashlee M; Tillman, Alex; Rantalainen, Timo; Muthalib, Makii; Johnson, Liam; Kidgell, Dawson J; Wundersitz, Daniel; Enticott, Peter G; Teo, Wei-Peng

    2016-07-19

    Parkinson's disease (PD) results from a loss of dopamine in the brain, leading to movement dysfunctions such as bradykinesia, postural instability, resting tremor and muscle rigidity. Furthermore, dopamine deficiency in PD has been shown to result in maladaptive plasticity of the primary motor cortex (M1). Progressive resistance training (PRT) is a popular intervention in PD that improves muscular strength and results in clinically significant improvements on the Unified Parkinson's Disease Rating Scale (UPDRS). In separate studies, the application of anodal transcranial direct current stimulation (a-tDCS) to the M1 has been shown to improve motor function in PD; however, the combined use of tDCS and PRT has not been investigated. We propose a 6-week, double-blind randomised controlled trial combining M1 tDCS and PRT of the lower body in participants (n = 42) with moderate PD (Hoehn and Yahr scale score 2-4). Supervised lower body PRT combined with functional balance tasks will be performed three times per week with concurrent a-tDCS delivered at 2 mA for 20 minutes (a-tDCS group) or with sham tDCS (sham group). Control participants will receive standard care (control group). Outcome measures will include functional strength, gait speed and variability, balance, neurophysiological function at rest and during movement execution, and the UPDRS motor subscale, measured at baseline, 3 weeks (during), 6 weeks (post), and 9 weeks (retention). Ethical approval has been granted by the Deakin University Human Research Ethics Committee (project number 2015-014), and the trial has been registered with the Australian New Zealand Clinical Trials Registry (ACTRN12615001241527). This will be the first randomised controlled trial to combine PRT and a-tDCS targeting balance and gait in people with PD. The study will elucidate the functional, clinical and neurophysiological outcomes of combined PRT and a-tDCS. It is hypothesised that combined PRT and a-tDCS will significantly

  13. Introduction to the 2012-2013 Tolbachik eruption special issue

    Science.gov (United States)

    Edwards, Benjamin R.; Belousov, Alexander; Belousova, Marina; Volynets, Anna

    2015-12-01

    The Tolbachik volcanic complex in central Kamchatka holds a special place in global volcanological studies. It is one of 4 areas of extensive historic volcanic activity in the northern part of the Central Kamchatka Depression (the others being Klyuchevskoy, Bezymianny, Shiveluch), and is part of the Klyuchevskoy volcanic group, which is one of the most active areas of volcanism on Earth. Tolbachik is especially well-known due largely to the massive 1975-1976 eruption that became known as the Great Tolbachik Fissure eruption (GTFE; Fedotov, 1983; Fedotov et al., 1984). This was one of the first eruptions in Russia to be predicted based on precursory seismic activity, based on M5 earthquakes approximately one week before the eruption started, and was intensively studied during its course by a large number of Russian scientists. A summary of those studies was published, first in Russian and then in English, and it became widely read for many reasons. One in particular is that the eruption was somewhat unusual for a subduction zone setting; although many subduction zone stratovolcanoes have associated basaltic tephra cone-lava fields, this was the first such Hawaiian-style eruption to be widely observed. After the end of the eruption in 1976, the complex showed no signs of activity until 27 November 2012, when increased seismic activity was registered by the Kamchatka Branch of the Russian Geophysical Survey and a red glow from the eruption site was first noticed through the snowstorm haze. This prompted them, and then the Kamchatka Volcanic Emergency Response Team (KVERT) to issue an alert that activity was coming from the south flank of Plosky Tolbachik volcano, the younger of two volcanic edifices (the older is Ostry Tolbachik) that together make up the bulk of the complex along with tephra cone-lava fields that lie along a NE-SW fissure zone that transects Plosky Tolbachik. The new eruption lasted for more than 250 days and, like the 1975-1976 eruption, was

  14. CT-guided periradicular therapy in cervical and lumbar radicular syndromes

    International Nuclear Information System (INIS)

    Nian Dingfang; Zhou Jun; Li Wenhua; Cao Qingxuan; Xia Baosu; Apitzsch, D.E.

    2007-01-01

    Objective: To evaluate the effectiveness of CT-guided periradicular therapy (PRT) in cervical and lumber radicular syndromes. Methods: Seventy two cases of cervical and lumbar radicular syndromes were treated by CT-guided PRT. During PRT, 10-20 mg of Triamhexal and 3-4 ml of Carbostesin 0.25%(Bupivacainhydrochlorid) were injected into the space around the corresponding spinal root, once a week, all together six times as a course. Results: Four hundreds and forty six PRT procedures were carried out in 72 patients having a successful puncture and a satisfying spread of Triamhexal and Carbostesin around the spinal nerve root space for every time. After 6 to 24 months follow up, 62 patients showed a significant pain reduction or complete disappearance. Moderate improvement was not noted in 6 and no improvement in 4. The effective rate was 94.4% without any correlative complication. Conclusions: CT-guided PRT is an effective, easy and safe procedure to treat patients with refractory cervical or lumbar radicular pain syndromes. (authors)

  15. Relationships among age, gender, anthropometric characteristics, and dynamic balance in children 5 to 12 years old.

    Science.gov (United States)

    Butz, Sarah M; Sweeney, Jane K; Roberts, Pamela L; Rauh, Mitchell J

    2015-01-01

    To examine relationships among age, gender, anthropometrics, and dynamic balance. Height, weight, and arm and foot length were measured in 160 children with typical development aged 5 to 12 years. Dynamic balance was assessed using the Timed Up and Go (TUG) test, Pediatric Reach Test (PRT), and Pediatric Balance Scale (PBS). Moderate to good positive relationships (r = 0.61 and r = 0.56) were found between increasing age and PRT and PBS scores. A fair negative relationship (r = -0.49) was observed between age and TUG test. No significant gender-by-age group difference was observed. Age had the strongest influence on TUG and PBS scores; arm length had the strongest influence on PRT scores. Dynamic balance ability is directly related to chronological age. Age and arm length have the strongest relationships with balance scores. These findings may assist pediatric therapists in selecting dynamic balance tests according to age rather than specific diagnosis.

  16. Habituation of exploratory activity in aged rats: effects of pyritinol Habituação da atividade exploratória em ratos idosos: efeitos do piritinol

    Directory of Open Access Journals (Sweden)

    Roberto DeLucia

    2005-03-01

    Full Text Available Acetylcholine (Ach is a neurotransmitter considered to play a critical role in processes underlying behavior, learning, and memory. Pyritinol (pyrithioxine, Encephabolâ, PRT is a nootropic drug that increases cholinergic transmission in the central nervous system. Behavioral habituation following multiple exposures to an open field is an experimental paradigm frequently used to assess the cognitive actions of drugs. In this paradigm the decrease of exploratory activity as a function of repeated exposure to the same environment is taken as an index memory. In the present study, effects PRT administrated to aged rats in powder form added to the diet (200 mg /kg / day, p.o., for 14 days were evaluated in the habituation to an open field. A total of 18 aged rats were randomly assigned to one of two groups control (vehicle-treated rats, n = 8 and experimental group (PRT-treated rats, n = 10 and were used in the following procedure. In the exploratory task, the post-training treatment with PRT significantly decreased the number of total area crossings and rears when compared to the control group, indicating habituation. PRT treatment enhanced retention in the total number of area crossings and rears when compared with control animals. Taken together, the data of present study suggest that muscarinic cholinergic systems could be involved in the effect of PRT in habituation of exploratory activity to an open field in aged rats.A acetilcolina é um neurotransmissor que desempenha considerável papel crítico nos processos subjacentes ao comportamento, aprendizagem e memória. Piritinol (piritioxina, Encefabolâ, PRT é um fármaco nootrópico que aumenta a transmissão colinérgica no sistema nervoso central. Habituação comportamental seguida de múltipla exposição no campo aberto é um paradigma experimental freqüentemente usado na avaliação das ações cognitivas de fármacos. Neste paradigma, a diminuição da atividade exploratória em fun

  17. Gamma knife surgery for pineal region tumors: an alternative strategy for negative pathology

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Peng [Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu (China); Department of Neurosurgery, The Fifth People' s Hospital of Chengdu, Chengdu (China); Mao, Qing; Wang, Wei; Zhou, Liang-Xue; Liu, Yan-Hui, E-mail: liuyanhui9@gmail.com [Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu (China)

    2014-03-01

    Objective: pineal region tumors (PRTs) are uncommon, and treatments vary among neoplasm types. The authors report their experience with gamma knife surgery (GKS) as an initial treatment in a series of PRT patients with unclear pathological diagnoses. Method: seventeen PRT patients with negative pathology who underwent GKS were retrospectively studied. Nine patients had further whole-brain and spinal cord radiotherapy and chemotherapy 6-9 months after GKS. Results: Sixteen of 17 cases were followed up over a mean of 33.3 months. The total response rate was 75%, and the control rate was 81.3%. No obvious neurological deficits or complications were attributable to GKS. Conclusion: the findings indicate that GKS may be an alternative strategy in selected PRT patients who have negative pathological diagnoses, and that good outcomes and quality of life can be obtained with few complications. (author)

  18. The role of peer review in responsive decisions - a case study of clean-up and safe long-term management of historic waste at Port Hope and Clarington

    International Nuclear Information System (INIS)

    Hardy, D.

    2006-01-01

    'Full text:' The Municipalities of Port Hope and Clarington ('Municipalities') are committed to leading the clean- up and safe long-term management of historic low- level radioactive and hazardous wastes deposited in Port Granby (in the Municipality of Clarington) and several locations in the Municipality of Port Hope. They are supported by the Government of Canada through Atomic Energy of Canada Limited's (AECL) Low- Level Radioactive Waste Management Office (LLRWMO). The wastes are the result of radium and uranium processing in Port Hope by Eldorado since the 1930s. To establish the parameters of the clean- up, including the ability to veto the project, the local municipalities negotiated and signed a Legal Agreement with the Government of Canada in 2001. As a Responsible Authority, Natural Resources Canada has defined and approved the scope of the two projects. The LLRWMO is designated as the proponent. Accordingly, the LLRWMO is conducting the Environmental Assessment (EA) Studies and seeking approval of a preferred method of conducting the clean up for each municipality. The municipalities recognized that these large and complex environmental assessment studies would challenge the resources of citizens, municipal professional staff and politicians. Thus, the Legal Agreement specified that both municipalities would have funded staff to work together to coordinate and expedite the project. A Peer Review Team (PRT) would be retained by the municipalities and funded by the Government of Canada. The PRT is made up of experienced professionals led by Hardy Stevenson and Associates Limited in disciplines appropriate to the peer review tasks on hand. The PRT has brought a unique approach to the peer review. The PRT is headed by planners and social scientists trained to be sensitive to the 'people aspects' of the EA process as a major priority. They are supported by engineers and technical specialists. The team includes a physician with a family practice who is also an

  19. A Functional Thinking Approach to the Design of Future Transportation Systems: Taxis as a Proxy for Personal Rapid Transit in South Korea

    DEFF Research Database (Denmark)

    Thompson, Mary Kathryn; Bae, Hyun Hye

    2014-01-01

    For over 50 years, personal rapid transit (PRT) has been viewed as one of the most promising ways to provide sustainable, economical, and convenient transportation while reducing reliance on personal automobiles. However, despite concerted efforts around the world, the promise of PRT has yet...... to be realized. This work demonstrates that different physical means, such as the Korean taxi system, can be used to perform the same highest-level functional requirement, satisfy the same constraints, and provide many of the benefits that are expected of a city-scale personal rapid transit system. Thus, Korean...... taxis can be used as an alternative embodiment of personal rapid transit and can serve as a test bed to support PRT-related design, research, and development. The paper then explores the transportation patterns and characteristics of cities in South Korea and the United States in order to determine...

  20. Addressing the risk of bacterial contamination in platelets: a hospital economic perspective.

    Science.gov (United States)

    Li, Justin W; Brecher, Mark E; Jacobson, Jessica L; Harm, Sarah K; Chen, Dorothy; El-Gamil, Audrey; Dobson, Al; Mintz, Paul D

    2017-10-01

    Bacterially contaminated platelets (PLTs) remain a serious risk. The Food and Drug Administration has issued draft guidance recommending hospitals implement secondary testing or transfuse PLTs that have been treated with pathogen reduction technology (PRT). The cost implications of these approaches are not well understood. We modeled incurred costs when hospitals acquire, process, and transfuse PLTs that are PRT treated with INTERCEPT (Cerus Corp.) or secondary tested with the PLT PGD Test (Verax Biomedical). Hospitals will spend $221.27 (30.0%) more per PRT-treated apheresis PLT unit administered compared to a Zika-tested apheresis PLT unit that is irradiated and PGD tested in hospital. This difference is reflected in PRT PLT units having: 1) a higher hospital purchase price ($100.00 additional charge compared to an untreated PLT); 2) lower therapeutic effectiveness than untreated PLTs among hematologic-oncologic patients, which contributes to additional transfusions ($96.05); or 3) fewer PLT storage days, which contributes to higher outdating cost from expired PLTs ($67.87). Only a small portion of the incremental costs for PRT-treated PLTs are offset by costs that may be avoided, including primary bacterial culture, secondary bacterial testing ($26.65), hospital irradiation ($8.50), Zika testing ($4.47), and other costs ($3.03). The significantly higher cost of PRT-treated PLTs over PGD-tested PLTs should interest stakeholders. For hospitals that outdate PLTs, savings associated with expiration extension to 7 days by adding PGD testing will likely be substantially greater than the cost of implementing PGD-testing. Our findings might usefully inform a hospital's decision to select a particular blood safety approach. © 2017 The Authors Transfusion published by Wiley Periodicals, Inc. on behalf of AABB.

  1. Clinical and dosimetric predictors of acute hematologic toxicity in rectal cancer patients undergoing chemoradiotherapy

    International Nuclear Information System (INIS)

    Yang, T. Jonathan; Oh, Jung Hun; Apte, Aditya; Son, Christina H.; Deasy, Joseph O.; Goodman, Karyn A.

    2014-01-01

    Background and purpose: To identify clinical and dosimetric factors associated with hematologic toxicity (HT) during chemoradiotherapy for rectal cancer. Materials and methods: We analyzed 120 rectal cancer patients treated with neoadjuvant pelvic radiotherapy (PRT) with concurrent 5-fluorouracil-based chemotherapy. The coxal (ilium, ischium, and pubis) bone marrow (BM), sacral BM, and femoral BM were contoured and dose-volume parameters were extracted. Associations between cell count trend and clinical predictors were tested using repeated-measures analysis of variance (ANOVA) test. Associations between clinical variables, Vx (percentage volume receiving x Gy), and cell count ratio at nadir were tested using linear regression models. Results: Nadirs for white blood cell count (WBC), absolute neutrophil count (ANC), and platelets (PLT) occurred in the second week of PRT and the fifth week for hemoglobin and absolute lymphocyte count (ALC). Using cell count ratio, patients treated with 3DCRT had a lower WBC ratio trend during PRT compared to patients treated with IMRT (p = 0.04), and patients ⩾59 years of age had a lower hemoglobin ratio trend during PRT (p = 0.02). Using absolute cell count, patients treated with 3DCRT had lower ANC cell count trend (p = 0.03), and women had lower hemoglobin cell count trend compared to men (p = 0.03). On univariate analysis, use of 3DCRT was associated with a lower WBC ratio at nadir (p = 0.02). On multiple regression analysis using dosimetric variables, coxal BM V45 (p = 0.03) and sacral BM V45 (p = 0.03) were associated with a lower WBC and ANC ratio at nadir, respectively. Conclusions: HT trends during PRT revealed distinct patterns: WBC, ANC, and PLT cell counts reach nadirs early and recover, while hemoglobin and ALC decline steadily. Patients who were treated with 3DCRT and older patients experienced lower cell count ratio trend during PRT. Dosimetric constraints using coxal BM V45 and sacral BM V45 can be considered

  2. Identification of SlpB, a Cytotoxic Protease from Serratia marcescens.

    Science.gov (United States)

    Shanks, Robert M Q; Stella, Nicholas A; Hunt, Kristin M; Brothers, Kimberly M; Zhang, Liang; Thibodeau, Patrick H

    2015-07-01

    The Gram-negative bacterium and opportunistic pathogen Serratia marcescens causes ocular infections in healthy individuals. Secreted protease activity was characterized from 44 ocular clinical isolates, and a higher frequency of protease-positive strains was observed among keratitis isolates than among conjunctivitis isolates. A positive correlation between protease activity and cytotoxicity to human corneal epithelial cells in vitro was determined. Deletion of prtS in clinical keratitis isolate K904 reduced, but did not eliminate, cytotoxicity and secreted protease production. This indicated that PrtS is necessary for full cytotoxicity to ocular cells and implied the existence of another secreted protease(s) and cytotoxic factors. Bioinformatic analysis of the S. marcescens Db11 genome revealed three additional open reading frames predicted to code for serralysin-like proteases noted here as slpB, slpC, and slpD. Induced expression of prtS and slpB, but not slpC and slpD, in strain PIC3611 rendered the strain cytotoxic to a lung carcinoma cell line; however, only prtS induction was sufficient for cytotoxicity to a corneal cell line. Strain K904 with deletion of both prtS and slpB genes was defective in secreted protease activity and cytotoxicity to human cell lines. PAGE analysis suggests that SlpB is produced at lower levels than PrtS. Purified SlpB demonstrated calcium-dependent and AprI-inhibited protease activity and cytotoxicity to airway and ocular cell lines in vitro. Lastly, genetic analysis indicated that the type I secretion system gene, lipD, is required for SlpB secretion. These genetic data introduce SlpB as a new cytotoxic protease from S. marcescens. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  3. Lower limb progressive resistance training improves leg strength but not gait speed or balance in Parkinson's disease: a systematic review and meta-analysis.

    Science.gov (United States)

    Tillman, Alex; Muthalib, Makii; Hendy, Ashlee M; Johnson, Liam G; Rantalainen, Timo; Kidgell, Dawson J; Enticott, Peter G; Teo, Wei-Peng

    2015-01-01

    The use of progressive resistance training (PRT) to improve gait and balance in people with Parkinson's disease (PD) is an emerging area of interest. However, the main effects of PRT on lower limb functions such as gait, balance, and leg strength in people with PD remain unclear. Therefore, the aim of the meta-analysis is to evaluate the evidence surrounding the use of PRT to improve gait and balance in people with PD. Five electronic databases, from inception to December 2014, were searched to identify the relevant studies. Data extraction was performed by two independent reviewers and methodological quality was assessed using the PEDro scale. Standardized mean differences (SMD) and 95% confidence intervals (CIs) of fixed and random effects models were used to calculate the effect sizes between experimental and control groups and I (2) statistics were used to determine levels of heterogeneity. In total, seven studies were identified consisting of 172 participants (experimental n = 84; control n = 88). The pooled results showed a moderate but significant effect of PRT on leg strength (SMD 1.42, 95% CI 0.464-2.376); however, no significant effects were observed for gait speed (SMD 0.418, 95% CI -0.219 to 1.055). No significant effects were observed for balance measures included in this review. In conclusion, our results showed no discernable effect of PRT on gait and balance measures, although this is likely due to the lack of studies available. It may be suggested that PRT be performed in conjunction with balance or task-specific functional training to elicit greater lower limb functional benefits in people with PD.

  4. Lower Limb Progressive Resistance Training Improves Leg Strength but Not Gait Speed or Balance in Parkinson’s Disease: A Systematic Review and Meta-Analysis

    Science.gov (United States)

    Tillman, Alex; Muthalib, Makii; Hendy, Ashlee M.; Johnson, Liam G.; Rantalainen, Timo; Kidgell, Dawson J.; Enticott, Peter G.; Teo, Wei-Peng

    2015-01-01

    The use of progressive resistance training (PRT) to improve gait and balance in people with Parkinson’s disease (PD) is an emerging area of interest. However, the main effects of PRT on lower limb functions such as gait, balance, and leg strength in people with PD remain unclear. Therefore, the aim of the meta-analysis is to evaluate the evidence surrounding the use of PRT to improve gait and balance in people with PD. Five electronic databases, from inception to December 2014, were searched to identify the relevant studies. Data extraction was performed by two independent reviewers and methodological quality was assessed using the PEDro scale. Standardized mean differences (SMD) and 95% confidence intervals (CIs) of fixed and random effects models were used to calculate the effect sizes between experimental and control groups and I2 statistics were used to determine levels of heterogeneity. In total, seven studies were identified consisting of 172 participants (experimental n = 84; control n = 88). The pooled results showed a moderate but significant effect of PRT on leg strength (SMD 1.42, 95% CI 0.464–2.376); however, no significant effects were observed for gait speed (SMD 0.418, 95% CI −0.219 to 1.055). No significant effects were observed for balance measures included in this review. In conclusion, our results showed no discernable effect of PRT on gait and balance measures, although this is likely due to the lack of studies available. It may be suggested that PRT be performed in conjunction with balance or task-specific functional training to elicit greater lower limb functional benefits in people with PD. PMID:25852550

  5. Exercise in myasthenia gravis: A feasibility study of aerobic and resistance training

    DEFF Research Database (Denmark)

    Rahbek, Martin Amadeus; Mikkelsen, Erik Elgaard; Overgaard, Kristian

    2017-01-01

    Introduction: It has not been established whether progressive resistance training (PRT) and aerobic training (AT) are feasible and efficient in myasthenia gravis (MG). Methods: Fifteen subjects with generalized MG (Myasthenia Gravis Foundation of America (MGFA) clinical classification II-IV) were...... randomly assigned to 20 training sessions during 8 weeks of either PRT or AT. Feasibility was evaluated based on adherence, drop-out rate, adverse events, and Quantitative Myasthenia Gravis (QMG) score. Results: Twelve subjects (MGFA II, n = 11; MGFA III, n=1) completed the intervention with a mean...

  6. Fetal irradiation of the fetus patient during periradicular therapy

    International Nuclear Information System (INIS)

    Salat, D.; Klepanec, A.

    2018-01-01

    In this presentation, female fetal irradiation in periradicular therapy (PRT) is described. Although such CT examinations are not acute, there are cases where pregnant women are also exposed, as is shown in this case study. Fetal dose calculation was performed using the Monte Carlo simulation contained in the DQC system, designed to automatically monitor patient radiation at the CT workplace. Also, the process of optimization of radiation protection has not been sufficiently implemented in the CT workplace. Consistent with the basic principles of radiation protection would avoid unnecessary risks high fetal doses in PRT examinations. (authors)

  7. Progressive strength training to prevent LYmphoedema in the first year after breast CAncer

    DEFF Research Database (Denmark)

    Ammitzbøll, Gunn; Lanng, Charlotte; Kroman, Niels

    2017-01-01

    BACKGROUND: Lymphoedema is a common late effect after breast cancer (BC) that has no effective cure once chronic. Accumulating evidence supports progressive strength training (PRT) as a safe exercise modality in relation to the onset and exacerbation of lymphoedema. In the 'preventive intervention...... against LYmphoedema after breast CAncer' (LYCA) feasibility study we examined the feasibility of a program of PRT in the first year after BC to inform a planned randomised controlled trial (RCT). MATERIAL AND METHODS: LYCA was a one-group prospective pilot trial inviting women operated with axillary lymph...

  8. Acute Effects of Plyometric and Resistance Training on Running Economy in Trained Runners.

    Science.gov (United States)

    Marcello, Richard T; Greer, Beau K; Greer, Anna E

    2017-09-01

    Marcello, RT, Greer, BK, and Greer, AE. Acute effects of plyometric and resistance training on running economy in trained runners. J Strength Cond Res 31(9): 2432-2437, 2017-Results regarding the acute effects of plyometrics and resistance training (PRT) on running economy (RE) are conflicting. Eight male collegiate distance runners (21 ± 1 years, 62.5 ± 7.8 ml·kg·min V[Combining Dot Above]O2 peak) completed V[Combining Dot Above]O2 peak and 1 repetition maximum (1RM) testing. Seven days later, subjects completed a 12 minutes RE test at 60 and 80% V[Combining Dot Above]O2 peak, followed by a PRT protocol or a rested condition of equal duration (CON). The PRT protocol consisted of 3 sets of 5 repetitions at 85% 1RM for barbell squats, Romanian deadlifts, and barbell lunges; the same volume was used for resisted lateral lunges, box jumps, and depth jumps. Subjects completed another RE test immediately after the treatments and 24 hours later. Subjects followed an identical protocol 6 days later with condition assignment reversed. Running economy was determined by both relative V[Combining Dot Above]O2 (ml·kg·min) and energy expenditure (EE) (kcal·min). There was a significant (p ≤ 0.05) between-trial increase in V[Combining Dot Above]O2 (37.1 ± 4.2 ml·kg·min PRT vs. 35.5 ± 3.9 ml·kg·min CON) and EE (11.4 ± 1.3 kcal·min PRT vs. 11.0 ± 1.4 kcal·min CON) immediately after PRT at 60% V[Combining Dot Above]O2 peak, but no significant changes were observed at 80% V[Combining Dot Above]O2 peak. Respiratory exchange ratio was significantly (p ≤ 0.05) reduced 24 hours after PRT (0.93 ± 0.0) as compared to the CON trial (0.96 ± 0.0) at 80% V[Combining Dot Above]O2 peak. Results indicate that high-intensity PRT may acutely impair RE in aerobically trained individuals at a moderate running intensity, but that the attenuation lasts less than 24 hours in duration.

  9. Factors affecting initial training success of blood glucose testing in captive chimpanzees (Pan troglodytes)

    DEFF Research Database (Denmark)

    Reamer, Lisa A; Haller, Rachel L; Thiele, Erica J

    2014-01-01

    Type 2 diabetes can be a problem for captive chimpanzees. Accurate blood glucose (BG) readings are necessary to monitor and treat this disease. Thus, obtaining voluntary samples from primates through positive reinforcement training (PRT) is critical. The current study assessed the voluntary...... participation of 123 chimpanzees in BG sampling and investigated factors that may contribute to individual success. All subjects participate in regular PRT sessions as part of a comprehensive behavioral management program. Basic steps involved in obtaining BG values include: voluntarily presenting a finger...

  10. Analysis performed in cooperation with the SALE program, (1)

    International Nuclear Information System (INIS)

    Tuboya, Takao; Wada, Yukio; Suzuki, Takeshi

    1978-01-01

    One of the objects of the SALE (Safeguard Analytical Laboratory Evaluation) program is a development of technique in safeguard and accountability. The SALE program was established by the United States Atomic Energy Commission's New Brunswick Laboratory in 1970. Six years later, SALE program has grown into a worldwide quality control program, receiving analysis results from about 60 laboratories that includes 19 non-U.S. laboratories. All laboratories, participating at present or in the past in the SALE program are listed in Table 1. By 1973, the program was expanded to include six different materials; uranium dioxide (UO 2 ), uranyl nitrate (U-NO 3 ), plutonium dioxide (PuO 2 ), plutonium nitrate (Pu-NO 3 ), uranium-plutonium mixed oxides [(Pu,U)O 2 ], and uranium-plutonium mixed nitrates (Pu-U-NO 3 ). PNC has joined in this program in 1975 for the analysis of samples shown in Table 2. SALE program participants analyze, on a bimonthly basis, materials supplied by the New Brunswick Laboratory (NBL) and report measurement results to NBL for evaluation and inclusion in the bimonthly reports. Present paper describes analysis result and evaluations for these samples which were measured in 1975 -- 1976. (author)

  11. Reporting on nuclear power: the Tennessee Valley case

    International Nuclear Information System (INIS)

    Shapley, D.

    1977-01-01

    The Tennessee Valley Authority (TVA), by deciding to have 90 percent of its new generating capacity nuclear, has made the valley a testing ground for civilian nuclear power, but valley newspapers have not provided consumers with enough information on either the pros or cons. A 1975 Browns Ferry plant fire, the most serious in the history of the civilian nuclear industry, prompted some nuclear critics to question TVA's competence to plan and manage the program. Newspapers carried wire-service stories of the fire, while their editorials gave strong support to TVA and the effort to reopen the plant. Valley newspapers have traditionally favored TVA as a powerful economic and political force which has brought many benefits. Local pride in the Oak Ridge Laboratory and plant facilities and the Federal fast-breeder reactor project headquarters also enhanced the positive attitude of the press, which tended to report details but not question nuclear safety or TVA ability. Newspapers have also failed to question TVA's claims that rates will decline as nuclear plants begin operating. A review of relevant news stories during the 1975--1976 period addresses the press coverage and notes its failure to question whether power demands justify TVA's plant construction program. Knowledgeable consultants are available to provide information on the issues, while editors are advised to give comprehensive, critical coverage and avoid promotion

  12. Magnetic field of the Sun as a star, 1969-1976

    International Nuclear Information System (INIS)

    Kotov, V.A.; Demidov, M.L.

    1980-01-01

    A superposed epoch analysis of the solar mean magnetic field measured in Crimea during 1969-1976 was performed about 215 sector boundaries as observed at Earth. Mean field has showed quite good organization about sector boundaries with a typical field strength of about 0.4-0.3 Grin average sector. There is a significant difference between (+, -) and (-, +) boundaries with respect to the value of dH/dt (approximately 0.20 and 0.08 Gs/day respectively). It is found that average magnitude of the mean field has decreased from 0.5 Gs in 1969-1970 to 0.15 Gs in 1975-1976. The most principal recurrence period found in the data is 27sup(d),04+-0sup(d),06; resultant 27sup(d),04-curve exhibits remarcable asymmetry between magnetic fields of opposite signs (duration of S polarity is by 3-4 days larger than that of N polarity)

  13. Memory for Public Events in Mild Cognitive Impairment and Alzheimer's Disease: The Importance of Rehearsal.

    Science.gov (United States)

    Langlois, Roxane; Joubert, Sven; Benoit, Sophie; Dostie, Valérie; Rouleau, Isabelle

    2016-01-01

    Ribot's law refers to the better preservation of remote memories compared with recent ones that presumably characterizes retrograde amnesia. Even if Ribot-type temporal gradient has been extensively studied in retrograde amnesia, particularly in Alzheimer's disease (AD), this pattern has not been consistently found. One explanation for these results may be that rehearsal frequency rather than remoteness accounts for the better preservation of these memories. Thus, the aim of present study was to address this question by studying retrograde semantic memory in subjects with amnestic mild cognitive impairment (aMCI) (n = 20), mild AD (n = 20) and in healthy older controls (HC; n = 19). In order to evaluate the impact of repetition as well as the impact of remoteness, we used a test assessing memory for enduring and transient public events that occurred in the recent and remote past. Results show no clear temporal gradient across time periods (1960-1975; 1976-1990; 1991-2005; 2006-2011), but a better performance was observed in all three groups for enduring compared with transient events. Moreover, although deficits were globally found in both patients groups compared with HC, more specific analyses revealed that aMCI patients were only impaired on transient events while AD patients were impaired on both transient and enduring events. Exploratory analyses also revealed a tendency suggesting preservation of remote transient events in aMCI. These findings are discussed with regards to memory consolidation models.

  14. Near-surface distribution of radium in the Gulf of Mexico and Caribbean Sea: temporal and spatial variability and hydrographic relationships

    International Nuclear Information System (INIS)

    Reid, D.F.

    1979-01-01

    Only a few radium measurements have been made in the near-surface (0-600m) Gulf of Mexico and Caribbean Sea. Published 228 Ra data from 1968 and 1973 reveal a significant increase of 228 Ra activity in the near-surface Gulf of Mexico. The increase has been attributed to factors affecting the water prior to its entry into the Caribbean-Gulf system. It has been proposed that 228 Ra can be used to study thermocline mixing rates, but few detailed studies have been made to test the validity of this hypothesis. Physical oceanographic evidence indicates that vertical mixing significantly impacts the upper 100 to 150 meters of the water column in the Gulf of Mexico. This dissertation reports and discusses the results of 123 measurements of the 228 Ra: 226 Ra activity ratio (radium activity ratio), and 73 measurements of 226 Ra in the 1975-1976 near-surface water columns of the Gulf of Mexico and Caribbean Sea. 228 Ra activities are calculated from the activity ratio and 226 Ra data

  15. Exploring the gender gap in healthcare management.

    Science.gov (United States)

    Weil, P; Haddock, C C; Barowsky, D

    1996-01-01

    A 1990 study by ACHE and the University of Iowa compared the career attainments and attitudes of a group of male and female healthcare executives. The research showed that among men and women who had entered the field at the same time and had achieved similar educational levels, women did not fare as well as men in terms of salary, position level, or job satisfaction. A follow-up to this study, which consisted of two parts, was conducted in 1995 by ACHE, the University of Alabama at Birmingham, and Lamalie Amrop International to learn whether the gender gap had narrowed. The 1990 study divided respondents into groups according to the year they entered healthcare management: 1971-1975, 1976-1980, or 1981-1985. The first part of the 1995 project was a replication study that paralleled the 1990 study, dividing a new pool of respondents into three groups: 1976-1980, 1981-1985, and 1986-1990. The second part of the follow-up project was a panel study, in which respondents from the 1990 study were surveyed again. Following are highlights from the 1995 study.

  16. Detection of hot gas in clusters of galaxies by observation of the microwave background radiation

    International Nuclear Information System (INIS)

    Gull, S.F.; Northover, K.J.E.

    1976-01-01

    It is stated that satellite observations have indicated that many rich clusters are powerful sources of x-rays. This has been interpreted as due to either thermal bremsstrahlung from very hot gas filling the clusters or as inverse Compton scattering of photons by relativistic electrons. Spectral evidence appears to favour a thermal origin for the radiation, implying the existence of large amounts of hot gas. This gas may be a major constituent of the Universe, and independent confirmation of its existence is very important. Observations are here reported of small diminutions in the cosmic microwave background radiation in the direction of several rich clusters of galaxies. This is considered to confirm the existence of large amounts of very hot gas in these clusters and to indicate that the x-radiation is thermal bremsstrahlung and not inverse Compton emission. The observations were made in 1975/1976 using the 25m. telescope at the SRC Appleton Laboratory at a frequency of 10.6 GH2, and details are given of the technique employed. (U.K.)

  17. The spectral and temporal behavior of the variable X-ray binary star Cyg X-1 in the hard region of X-radiation

    International Nuclear Information System (INIS)

    Steinle, H.

    1981-01-01

    In the present work the measurements of the X-ray spectrum of Cyg X-1 in the energy range 15 to 160 keV in the years 1975, 1976, 1977 are investigated. The measurements are of such a good quality, that a simple power spectrum as the best fit of a model to the data of Cyg X-1 can be excluded because the spectrum breaks off in the range 70-100 keV. The model of Sunyaev and Titarchuk which describes the comptonizing of protons will low energy in a hot plasma is used first time for filling to the Cyg X-1 spectra and it is seen, that the shape of the spectrum is represented in an excellent manner. From the parameters of the best fit to the spectrum from 1977 an electron temperature of 3.4 x 10 8 K and an optical depth tau = 5 for the plasma in which the photons are scattered are found. (orig./WB) [de

  18. Training of engineers for Czechoslovak nuclear programme at Czech Technical University in Prague

    International Nuclear Information System (INIS)

    Klik, F.; Stoll, I.

    1983-01-01

    Between the year 1959 and the 1970's specialists for the Czechoslovak nuclear programme were only educated at the Faculty of Nuclar and Physics Engineering. In the early 1970's instruction and research related to nuclear power generation was introduced at the mechanical engineering and electrical engineering faculties. The specialization ''Nuclear power facilities'' was introduced within the study field ''Thermal and nuclear machines and equipment'' at the mechanical engineering faculty, and the electrical engineering faculty opened the study course ''Nuclear power plants'' in the study year 1975/1976. Most specialists for the nuclear programme are educated at the Faculty of Nuclear and Physics Engineering in the field ''Nuclear chemical engineering'' and in specializations ''Theory and technology of nuclear reactors'', ''Dosimetry and application of ionizing radiation'' in the study field ''Nuclear engineering''. The Faculty of Nuclear and Physics Engineering also trains specialists in the field ''Structure and materials properties'', the study courses ''Measuring technology'' and ''Control technology'' are run at the electrical engineering faculty and at the mechanical engineering faculty were introduced study courses of ''Applied mechanics'' and ''Mechanical engineering technology''. Graduates of all said study courses may be employed in the nuclear programme. (E.S.)

  19. Cosmogony as an extrapolation of magnetospheric research

    International Nuclear Information System (INIS)

    Alfven, H.

    1984-03-01

    A theory of the origin and evolution of the Solar System (Alfven and Arrhenius, 1975: 1976) which considered electromagnetic forces and plasma effects is revised in the light of new information supplied by space research. In situ measurements in the magnetospheres and solar wind have changed our views of basic properties of cosmic plasmas. These results can be extrapolated both outwards in space, to interstellar clouds, backwards in time, to the formation of the solar system. The first extrapolation leads to a revision of some cloud properties which are essential for the early phases in the formation of stars and solar nebule. The latter extrapolation makes possible to approach the cosmogonic processes by extrapolation of (rather) well-known magnetospheric phenomena. Pioneer-Voyager observations of the Saturnian rings indicate that essential parts of their structure are fossils from cosmogonic times. By using detailed information from these space missions, it seems possible to reconstruct certain events 4-5 billion years ago with an accuracy of a few percent. This will cause a change in our views of the evolution of the solar system.(author)

  20. The Wernicke-Korsakoff syndrome: a reappraisal in Queensland with special reference to prevention.

    Science.gov (United States)

    Price, J; Kerr, R; Hicks, M; Nixon, P F

    The Wernicke-Korsakoff syndrome occurs most frequently in alcoholic patients when they become thiamin deficient. First admissions to psychiatric units with the chronic component of this syndrome, Korsakoff's psychosis, peaked in Queensland in 1975-1976. The fall in hospital admission rates since this time could relate to a decline in per-capita alcohol consumption in Australia, or to more awareness of the thiamin needs of drinkers. Alternatively, the improvement may be illusory: although many cases of Wernicke's encephalopathy are being diagnosed, many of these patients are not receiving psychiatric assessment and treatment, perhaps because admission to psychiatric hospital beds is more difficult than it was formerly. Patients who are diagnosed as having Korsakoff's psychosis fare badly in the community, and have a greatly increased mortality rate than do such patients in hospital. Optimal care for such patients is necessarily costly of medical resources. Of available preventive measures, evidence is presented to support the fortification of beer with thiamin and the provision of community educational programmes. The fortification of flour with thiamin may have little impact on the thiamin-deficiency syndromes that arise in problem drinkers in Queensland.

  1. On broadened definitions of instability for stars in thermal imbalance

    International Nuclear Information System (INIS)

    Simon, N.R.

    1977-01-01

    The classical theory of stability of dynamical systems is employed to demonstrate that traditional definitions of pulsational instability cannot be directly applied to stars in thermal imbalance. In particular, it is shown that, for the case of thermal imbalance, pulsational displacements and pulsational velocities have separate and distinct e-folding times. This being true, a broadened set of definitions becomes necessary, and such a set is formulated again with reference to the classical theory. In accordance with the new definitions, it is argued that the development of observable pulsations requires as a necessary condition infinitesimal instability of both absolute displacement and velocity. If either one is unstable without the other, this constitutes a class of (probably) non-pulsational instability, not previously treated in the astrophysical literature. Finally, it is shown that the stability of stars in thermal imbalance may be evaluated according to the present definitions by employing either of two existing theories - the energy approach due to Demaret (1974; 1975; 1976) or the small perturbation technique of Cox et al. (1973). (Auth.)

  2. The role of space communication in promoting national development with specific reference to experiments conducted in India

    Science.gov (United States)

    Chitnis, E. V.

    The paper describes the role of space communication in promoting national development with special reference to experiments conducted in India, namely SITE (1975-1976), STEP (1977-1979) and APPLE (1981 onwards). The impact of these experiments in economic, cultural and educational terms are discussed, pointing out social implications involved in using advance space communication technology for instruction and information in the areas of education, national integration and development. The paper covers special requirements which arise when a communication system covers backward and remote rural areas in a developing country. The impact on the population measured by conducting social surveys has been discussed - especially the gains of predominently illiterate new media - participants have been highlighted. Possibilities of improving skills of teachers, the quality of the primary and higher education have been covered. The preparation required both on ground as well as space to derive benefits of space technology are considered. A profile of INSAT which marks the culmination of the experimental phase and the beginning of operational domestic satellite system is sketched.

  3. Likelihood of early detection of breast cancer in relation to false-positive risk in life-time mammographic screening: population-based cohort study.

    Science.gov (United States)

    Otten, J D M; Fracheboud, J; den Heeten, G J; Otto, S J; Holland, R; de Koning, H J; Broeders, M J M; Verbeek, A L M

    2013-10-01

    Women require balanced, high-quality information when making an informed decision on screening benefits and harms before attending biennial mammographic screening. The cumulative risk of a false-positive recall and/or (small) screen-detected or interval cancer over 13 consecutive screening examinations for women aged 50 from the start of screening were estimated using data from the Nijmegen programme, the Netherlands. Women who underwent 13 successive screens in the period 1975-1976 had a 5.3% cumulative chance of a screen-detected cancer, with a 4.2% risk of at least one false-positive recall. The risk of being diagnosed with interval cancer was 3.7%. Two decades later, these estimates were 6.9%, 7.3% and 2.9%, respectively. The chance of detection of a small, favourable invasive breast cancer, anticipating a normal life-expectancy, rose from 2.3% to 3.7%. Extrapolation to digital screening mammography indicates that the proportion of false-positive results will rise to 16%. Dutch women about to participate in the screening programme can be reassured that the chance of false-positive recall in the Netherlands is relatively low. A new screening policy and improved mammography have increased the detection of an early screening carcinoma and lowering the risk of interval carcinoma.

  4. [Transurethral electroresection--an alternative to the indwelling catheter of old patients with prostatic hypertrophy].

    Science.gov (United States)

    Thiel, U; Krebs, W

    1978-01-01

    The people become elder in this time, everywhere. The number of patients with adenoma of the prostate is increasing. Most of them have other diseases, too. A retrospective study (2646 cases in 8 years, exactly specially analysed 469 cases from 1975/1976) was done, comparing the results of TUR and open surgery. Well known is the lower risk of TUR, the lower blood loss, the lower discomfort, the lower nursing in the postoperative period ect. There are not news in this study. But it is important, to recall some things, because it's more and more difficult, to classify an old man as an "inoperable case". Nobody knows, where he should stay. The family does not like him at home (his "dripping", his incontinence etc.) In the veterans house it's the same problem, and from the hospital he is removed, because he is an "inoperable case". The situation of this old man is very bad, because he feels there isn't a place for him and nobody likes him. Each man, also if it's the strongest one, will be broken psychically and physically after a short time. Concerning these aspects, must be enlarged the indication of removal the bladder neck obstruction per transurethral resection, more and more.

  5. Determination trends and abnormal seasonal wind speed in Iraq

    Energy Technology Data Exchange (ETDEWEB)

    Hassoon, Ahmed F. [Department of Atmospheric Sciences, College of Science, AL- Mustansiriyah University, Baghdad (Iraq)

    2013-07-01

    Monthly observed wind speed data at four weather stations (Baghdad, Mosul, Basra, Rutba) at 10m above surface were used to explore the temporal variations of the wind speed (1971-2000) in Iraq. There are different methods to analyze wind speed variation data, but the time series are one of the powerful analysis methods to diagnose the seasonal wind speed anomaly. The results show most high abnormal data is found in summer seasons in all the stations of study, where it concentrated at 1975, 1976, 1978,1996-1995, 2000. Rutba station is different where its high deviation about annual average at nearly all the seasons, in this station there are trends in seasonal wind towards decreases in all the seasons, for example in winter it reached to about 0.046m/s.a-1, while in other stations Mosul and Basra there increases in annual seasonal wind speed trends in seasons spring, summer, autumn where its reached higher value at summer in Basra about 0.0482m/s.a-1. The second method to determine abnormal annual seasonal wind speed is through comparison seasonal average wind speed, where the average wind speed at the seasons summer and spring in Baghdad and Basra station have very high averages at nearly all years, this cannot see in Mosul and Rutba, in Rutba the seasonal average is intersected with each other, summer and spring is not have greater seasonal average in this station.

  6. 37 CFR 1.823 - Requirements for nucleotide and/or amino acid sequences as part of the application.

    Science.gov (United States)

    2010-07-01

    ... may not include material other than part of the sequence listing. A fixed-width font should be used... integer expressing the number of bases or amino acid residues M. Type Whether presented sequence molecule is DNA, RNA, or PRT (protein). If a nucleotide sequence contains both DNA and RNA fragments, the type...

  7. Special Inspector General for Iraq Reconstruction

    Science.gov (United States)

    2010-10-30

    property law. Other PRT RoL initiatives focus on improving anticorruption awareness and ad- dressing detention and rehabilitation challenges for adults...and it has identified irriga- tion, seed inputs, storage, commercial farming, and applied expertise in dairying, poultry , and organics as areas of

  8. Autolysis of Lactococcus lactis is influenced by proteolysis

    NARCIS (Netherlands)

    Buist, G; Venema, G; Kok, J.

    1998-01-01

    The autolysin AcmA of Lactococcus lactis was shown to be degraded by the extracellular Lactococcal proteinase PrtP. Autolysis, as evidenced by reduction in optical density of a stationary-phase culture and concomitant release of intracellular proteins, was greatly reduced when L. lactis MG1363 cells

  9. In vitro cell quality of buffy coat platelets in additive solution treated with pathogen reduction technology

    DEFF Research Database (Denmark)

    Ostrowski, Sisse R; Bochsen, Louise; Salado-Jimena, José A

    2010-01-01

    Pathogen reduction technologies (PRTs) may induce storage lesion in platelet (PLT) concentrates. To investigate this, buffy coat PLTs (BCPs) in PLT additive solution (AS; SSP+) with or without Mirasol PRT (CaridianBCT Biotechnologies) were assessed by quality control tests and four-color flow...

  10. 77 FR 6816 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2012-02-09

    ... notification covers activities to be conducted by the applicant over a 5-year period. Applicant: Bar H Bar Land...: Bar H Bar Land & Cattle Company, Houston, TX; PRT-63872A The applicant requests a permit authorizing... covers activities to be conducted by the applicant over a 5-year period. Applicant: Diamond J Game Ranch...

  11. Immunogenicity of a malaria parasite antigen displayed by Lactococcus lactis in oral immunisations

    NARCIS (Netherlands)

    Ramasamy, R; Yasawardena, S; Zomer, A; Venema, G; Kok, J; Leenhouts, K

    2006-01-01

    A putative protective protein from Plasmodium falciparum merozoites, MSA2, was expressed in two different ways on the cell surface of the Gram-positive food-grade bacterium, Lactococcus lactis. The first display format exploits an LPXTG-type anchoring motif of the lactococcal proteinase PrtP to

  12. Shades of Cords in the Kush: The False Hope of Unity of Effort in American Counterinsurgency

    Science.gov (United States)

    2010-04-01

    together, exercise together. So, if they piss someone off at the Embassy compound, repercussions last for weeks. They don’t want to make waves in...the capital. If they piss off someone in the PRT [by ignoring the appeal from the field], what is that person going to do? Send an email? Ooooh!45

  13. Evaluation of Probabilistic Reasoning Evidence from Seventh-Graders

    Science.gov (United States)

    Erdem, Emrullah; Gürbüz, Ramazan

    2016-01-01

    The purpose of this study was to evaluate probabilistic reasoning of seventh-grade students (N=167) studying at randomly selected three middle schools that served low and middle socioeconomic areas in a city of Turkey. "Probabilistic Reasoning Test (PRT)" was developed and used as a data collection tool. In analyzing the data,…

  14. Agency Stovepipes vs Strategic Agility: Lessons We Need to Learn from Provincial Reconstruction Teams in Iraq and Afghanistan

    Science.gov (United States)

    2008-04-01

    soil testing labs, farming cooperatives, flood protection walls, veterinary services, solar meat chillers, poultry industry development, fish farms...measuring a PRT’s performance or effectiveness. Many of our sources observed that PRT operations have been and continue to be a “pick up game

  15. 76 FR 35464 - Endangered Species; Marine Mammals; Receipt of Applications for Permit

    Science.gov (United States)

    2011-06-17

    ... issued that allows such activities. Both laws require that we invite public comment before issuing these... laws and regulations. We will not consider or include in our administrative record comments we receive... a 5-year period. Applicant: Harvard University, Museum of Comparative Zoology, Cambridge, MA; PRT...

  16. Construction and maintenance of SUNY facilities at the National Synchrotron Light Source. Progress report, 1 July 1983-1 July 1984. Final report

    International Nuclear Information System (INIS)

    Bigeleisen, J.

    1984-01-01

    Research reported includes beamline facilities, X-21 beamline update, SUNY-PRT participation in the design and commissioning of the CHESS crystallography facility, surface physics, material and structure studies using EXAFS, x-ray standing wave studies of surfaces and interfaces, and surface diffraction of adsorbed polyatomic molecules

  17. Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer : Report of a multicenter randomized trial

    NARCIS (Netherlands)

    Marijnen, CAM; van de Velde, CJH; Putter, H; van den Brink, M; Maas, CP; Martijn, H; Rutten, HJ; Wiggers, T; Kranenbarg, EK; Leer, JWH; Stiggelbout, AM

    2005-01-01

    Background Few prospective studies have been performed about the impact of preoperative radiotherapy (PRT) or total mesorectal excision (TME) on health-related quality of life (HRQL) and sexual functioning in patients with resectable rectal cancer. This report describes the HRQL and sexual

  18. Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial.

    NARCIS (Netherlands)

    Marijnen, C.A.; Velde, C.J. van de; Putter, H.; Brink, M.; Maas, C.P.; Martijn, H.; Rutten, H.J.; Wiggers, T.; Kranenbarg, E.K.; Leer, J.W.H.; Stiggelbout, A.M.

    2005-01-01

    BACKGROUND: Few prospective studies have been performed about the impact of preoperative radiotherapy (PRT) or total mesorectal excision (TME) on health-related quality of life (HRQL) and sexual functioning in patients with resectable rectal cancer. This report describes the HRQL and sexual

  19. Interagency Task Forces: The Right Tools for the Job

    Science.gov (United States)

    2011-01-01

    of State: The Interagency and National Security, ed. Gabriel Marcella (Carlisle, PA: Strategic Studies Institute, December 2008), 420–21. 12. US...2006, S. Prt. 109-52, 2. 74. Defense Secretary Robert M. Gates, quoted in Gabriel Marcella , “Understanding the Interagency Process: The Challenge of

  20. The Effect of Post-Racial Theory on Education

    Science.gov (United States)

    Warren, Christopher A.

    2012-01-01

    The proliferation of post-racial theory (PRT) in both social and political spheres of dominant American hegemony has illustrated a desire among academic circles to move past race and racial categories in social analysis. However, absent within post-racial rhetoric is critical language on how to abolish racism and racial inequality. (Samad 2009) It…

  1. 76 FR 36934 - Endangered Species; Marine Mammals; Receipt of Applications for Permit

    Science.gov (United States)

    2011-06-23

    ... Entertainment Inc., Vienna, VA; PRT-37444A The applicant requests a permit to import for the purpose of... tiger (Panthera tigris altaica), and 6 tigers (Panthera tigris). The captive-born animals are being... following applicants each request a permit to import the sport- hunted [[Page 36935

  2. Neurorehabilitation with versus without resistance training after botulinum toxin treatment in children with cerebral palsy

    DEFF Research Database (Denmark)

    Bandholm, Thomas Quaade; Jensen, Bente Rona; Nielsen, Lone M

    2012-01-01

    Objective: To compare the effects of physical rehabilitation with (PRT) and without (CON) progressive resistance training following treatment of spastic plantarflexors with botulinum toxin type A (BoNT) in children with cerebral palsy (CP). Methods: Fourteen children with CP performed supervised...

  3. Effectiveness of a Novel Community-Based Early Intervention Model for Children with Autistic Spectrum Disorder

    Science.gov (United States)

    Smith, Isabel M.; Koegel, Robert L.; Koegel, Lynn K.; Openden, Daniel A.; Fossum, Kristin L.; Bryson, Susan E.

    2010-01-01

    The Nova Scotia early intensive behavior intervention model--NS EIBI (Bryson et al., 2007) for children with autistic spectrum disorders was designed to be feasible and sustainable in community settings. It combines parent training and naturalistic one-to-one behavior intervention employing Pivotal Response Treatment--PRT (R. Koegel & Koegel,…

  4. Examination of Studies Targeting Social Skills with Pivotal Response Treatment

    Science.gov (United States)

    Bozkus Genc, Gulden; Vuran, Sezgin

    2013-01-01

    In early education, especially in effective teaching to children with autism spectrum disorders, the teaching methods which are applicable in natural settings like pivotal response treatment (PRT) are commonly used. It is one of the naturalistic intervention models aiming to facilitate the stimulant-response generalization, decrease the dependency…

  5. Engineering of the Lactococcus lactis serine proteinase by construction of hybrid enzymes

    NARCIS (Netherlands)

    Boerrigter, Ingrid J.; Buist, Girbe; Haandrikman, Alfred J.; Nijhuis, Monique; Reuver, Marjon B. de; Siezen, Roland J.; Venema, Gerhardus; Vos, Willem M. de; Kok, Jan

    Plasmids containing wild-type and hybrid proteinase genes were constructed from DNA fragments of the prtP genes of Lactococcus lactis strains Wg2 and SK11. These plasmids were introduced into the plasmid-free strain L. lactis MG1363. The serine proteinases produced by these L. lactis strains were

  6. Noncompliance and Dissent with Cell Phone Policies: A Psychological Reactance Theoretical Perspective

    Science.gov (United States)

    Tatum, Nicholas T.; Olson, Michele K.; Frey, T. K.

    2018-01-01

    This study employed Brehm's psychological reactance theory (PRT) to understand why students do or do not choose to follow classroom cell phone policies. Results (N = 750) from this study demonstrate that when instructors discourage cell phone use for noninstructional reasons, students feel their autonomy has been threatened. These perceptions of…

  7. A Qualitative Review of Literature on Peer Review of Teaching in Higher Education: An Application of the SWOT Framework

    Science.gov (United States)

    Thomas, Susan; Chie, Qiu Ting; Abraham, Mathew; Raj, Sony Jalarajan; Beh, Loo-See

    2014-01-01

    The issues of professional accountability, faculty member development, and enhancing higher education quality in universities are gaining importance. A strategy that could increase personal control over teaching practices in addition to improving professional development among faculty members is peer review of teaching (PRT). Five themes that are…

  8. 76 FR 45303 - ING Asia Pacific High Dividend Equity Income Fund, et al.; Notice of Application

    Science.gov (United States)

    2011-07-28

    ... Premium Opportunity Fund (``IGA''); ING Global Equity Dividend and Premium Opportunity Fund (``IGD''); ING... Exchange. PRT has also issued preferred shares. Each Current Fund reserves the right to issue preferred... market price and its net asset value per common share (``NAV'')) and the relationship between such Fund's...

  9. 75 FR 38117 - Receipt of Applications for Permit

    Science.gov (United States)

    2010-07-01

    ..., 2010. ADDRESSES: Brenda Tapia, Division of Management Authority, U.S. Fish and Wildlife Service, 4401... available at any time. While you can ask us in your comment to withhold your personal identifying... Spidle, Bellville, TX; PRT-10399A The applicant requests a permit to import the sport-hunted trophy of...

  10. Physical Exercise and Multiple Sclerosis

    DEFF Research Database (Denmark)

    Dalgas, Ulrik

    Baggrund: Kun få ikke-kontrollerede studier har undersøgt effekten af progressive styrketræning hos patienter med multipel sklerose (MS).  Formål: Undersøgelsens formål var at teste om progressiv styrketræning (PRT) af benene forbedrer muskelstyrke, muskelmorfologi, funktionel kapacitet, træthed,...

  11. On the predictability of extreme events in records with linear and nonlinear long-range memory: Efficiency and noise robustness

    Science.gov (United States)

    Bogachev, Mikhail I.; Bunde, Armin

    2011-06-01

    We study the predictability of extreme events in records with linear and nonlinear long-range memory in the presence of additive white noise using two different approaches: (i) the precursory pattern recognition technique (PRT) that exploits solely the information about short-term precursors, and (ii) the return interval approach (RIA) that exploits long-range memory incorporated in the elapsed time after the last extreme event. We find that the PRT always performs better when only linear memory is present. In the presence of nonlinear memory, both methods demonstrate comparable efficiency in the absence of white noise. When additional white noise is present in the record (which is the case in most observational records), the efficiency of the PRT decreases monotonously with increasing noise level. In contrast, the RIA shows an abrupt transition between a phase of low level noise where the prediction is as good as in the absence of noise, and a phase of high level noise where the prediction becomes poor. In the phase of low and intermediate noise the RIA predicts considerably better than the PRT, which explains our recent findings in physiological and financial records.

  12. Accuracy and differential bias in copy number measurement of CCL3L1 in association studies with three auto-immune disorders.

    Science.gov (United States)

    Carpenter, Danielle; Walker, Susan; Prescott, Natalie; Schalkwijk, Joost; Armour, John Al

    2011-08-18

    Copy number variation (CNV) contributes to the variation observed between individuals and can influence human disease progression, but the accurate measurement of individual copy numbers is technically challenging. In the work presented here we describe a modification to a previously described paralogue ratio test (PRT) method for genotyping the CCL3L1/CCL4L1 copy variable region, which we use to ascertain CCL3L1/CCL4L1 copy number in 1581 European samples. As the products of CCL3L1 and CCL4L1 potentially play a role in autoimmunity we performed case control association studies with Crohn's disease, rheumatoid arthritis and psoriasis clinical cohorts. We evaluate the PRT methodology used, paying particular attention to accuracy and precision, and highlight the problems of differential bias in copy number measurements. Our PRT methods for measuring copy number were of sufficient precision to detect very slight but systematic differential bias between results from case and control DNA samples in one study. We find no evidence for an association between CCL3L1 copy number and Crohn's disease, rheumatoid arthritis or psoriasis. Differential bias of this small magnitude, but applied systematically across large numbers of samples, would create a serious risk of false positive associations in copy number, if measured using methods of lower precision, or methods relying on single uncorroborated measurements. In this study the small differential bias detected by PRT in one sample set was resolved by a simple pre-treatment by restriction enzyme digestion.

  13. Amotivation in schizophrenia: integrated assessment with behavioral, clinical, and imaging measures.

    Science.gov (United States)

    Wolf, Daniel H; Satterthwaite, Theodore D; Kantrowitz, Jacob J; Katchmar, Natalie; Vandekar, Lillie; Elliott, Mark A; Ruparel, Kosha

    2014-11-01

    Motivational deficits play a central role in disability caused by schizophrenia and constitute a major unmet therapeutic need. Negative symptoms have previously been linked to hypofunction in ventral striatum (VS), a core component of brain motivation circuitry. However, it remains unclear to what extent this relationship holds for specific negative symptoms such as amotivation, and this question has not been addressed with integrated behavioral, clinical, and imaging measures. Here, 41 individuals with schizophrenia and 37 controls performed a brief, computerized progressive ratio task (PRT) that quantifies effort exerted in pursuit of monetary reward. Clinical amotivation was assessed using the recently validated Clinical Assessment Interview for Negative Symptoms (CAINS). VS function was probed during functional magnetic resonance imaging using a monetary guessing paradigm. We found that individuals with schizophrenia had diminished motivation as measured by the PRT, which significantly and selectively related to clinical amotivation as measured by the CAINS. Critically, lower PRT motivation in schizophrenia was also dimensionally related to VS hypofunction. Our results demonstrate robust dimensional associations between behavioral amotivation, clinical amotivation, and VS hypofunction in schizophrenia. Integrating behavioral measures such as the PRT will facilitate translational efforts to identify biomarkers of amotivation and to assess response to novel therapeutic interventions. © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  14. 77 FR 54604 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2012-09-05

    ...) Those supported by quantitative information or studies; and (2) Those that include citations to, and... applicant requests a permit to export sport hunted trophies of one male addax (Addax nasomaculatus), one.... Applicant: John Fry, Carson City, NV; PRT-82592A The applicant requests a permit to import a sport-hunted...

  15. 78 FR 76171 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2013-12-16

    ...) Those supported by quantitative information or studies; and (2) Those that include citations to, and...: Geoffrey Ridder; Utopia, TX; PRT-00030B The applicant requests a permit to export the sport-hunted trophy... period. Multiple Applicants The following applicants each request a permit to import the sport- hunted...

  16. 78 FR 4162 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2013-01-18

    ...) Those supported by quantitative information or studies; and (2) Those that include citations to, and..., Greer, SC; PRT-89822A The applicant requests a permit to import a sport-hunted trophy of two male... import the sport- hunted trophy of one male bontebok (Damaliscus pygargus pygargus) culled from a captive...

  17. 77 FR 43108 - Endangered Species; Marine Mammals; Receipt of Applications for Permit

    Science.gov (United States)

    2012-07-23

    ... agency decisions are: (1) Those supported by quantitative information or studies; and (2) Those that... Taxidermy, Brady, TX; PRT-75675A The applicant requests a permit to export the sport-hunted trophy/ trophies... following applicants each request a permit to import the sport- hunted trophy of one male bontebok...

  18. Modularity and Perspectives of Command and Control of Contingent Army of the Czech Republic during the Operation in Afghanistan

    Science.gov (United States)

    2011-06-01

    are provided as needed: − RCP requesting – in favour of mobile patrols, due to engineer reconnaissance in areas with higher risk of IED occurrence... hospitals , EOD and other military specialists gradually operated. PRT established by the Czech Republic within the ISAF operation in the province of Logar

  19. 77 FR 74506 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2012-12-14

    ... applicant over a 5-year period. Families: Lemuridae Iguanidae Species: African wild dog (Lycaon pictus) Amur... Costa Rica, for the purpose of scientific research. This notification covers activities to be conducted... purpose of enhancement of the survival of the species. Applicant: Thomas Archipley, Okemos, MI; PRT-91717A...

  20. Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases

    Czech Academy of Sciences Publication Activity Database

    Hocková, Dana; Janeba, Zlatko; Naesens, L.; Edstein, M. D.; Chavchich, M.; Keough, D. T.; Guddat, L. W.

    2015-01-01

    Roč. 23, č. 17 (2015), s. 5502-5510 ISSN 0968-0896 R&D Projects: GA ČR GAP207/11/0108 Institutional support: RVO:61388963 Keywords : nucleotide analogues * enzyme inhibitors * malaria * HG(X)PRT * ANP Subject RIV: CC - Organic Chemistry Impact factor: 2.923, year: 2015

  1. McCallen Professional Research and Teaching Leave Report

    Energy Technology Data Exchange (ETDEWEB)

    McCallen, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-10-16

    This end of assignment report for a Professional Research and Teaching (PRT) Leave award includes the attached assessment of success by the host organization, University of California Davis (UCD). The following summarizes the accomplishments and attached are a selection of documented items.

  2. Increasing Opportunities for Question-Asking in School-Aged Children with Autism Spectrum Disorder: Effectiveness of Staff Training in Pivotal Response Treatment

    Science.gov (United States)

    Verschuur, Rianne; Huskens, Bibi; Verhoeven, Ludo; Didden, Robert

    2017-01-01

    Deficits in question-asking are common in children with autism spectrum disorder (ASD). Furthermore, their opportunities to self-initiate questions are often hindered by directive behavior of their conversation partners. This study assessed the effectiveness of staff training in pivotal response treatment (PRT) on staff member-created…

  3. U.S. EPA, Pesticide Product Label, SECURITY INDOOR INSECT FOGGER, 09/19/1988

    Science.gov (United States)

    2011-04-21

    ... ri Dc! (' .. t .r t .. --. 1 • ;"":t· i. t .. ," }1I t ~- !; I . .. jill • ~-, t} t , , (. ~ u I ", ;-cCur I' !. - ll.'J71pr't f1rlfr'n(:f inc ~ r~· r ".tf' 'I, rune! t." ! ,( I ; C):: • I •• ' : ' ...

  4. 76 FR 14985 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2011-03-18

    ... the applicant over a 5-year period. Applicant: Rosamond Gifford Zoo at Burnet Park, Syracuse, NY; PRT- 28295A The applicant requests a permit to re-import two captive born female Asian elephants (Elephas maximus) and one captive born male Asian elephant from African Lion Safari and Game Farm, Ontario, Canada...

  5. 76 FR 68205 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2011-11-03

    ... be conducted by the applicant over a 5-year period. Applicant: Honolulu Zoo, Honolulu, HI; PRT 699515... activities to be conducted by the applicant over a 5-year period. Families: Callithricidae, Canidae... include Aplonis pelzelni), Pelomedusidae, Testudinidae. Species: Asian elephant (Elephas maximus...

  6. 77 FR 41198 - Endangered Species; Marine Mammals; Receipt of Applications for Permit

    Science.gov (United States)

    2012-07-12

    ... scientific research. This notification covers activities conducted by the applicant over a 5-year period... Foundation, Denver, CO; PRT-69465A The applicant requests a permit to import two male Asian elephants... elephant (Elephas maximus) born in captivity from Dublin Zoo, Dublin, Ireland, for the purpose of...

  7. 75 FR 75491 - Endangered Species; Receipt of Applications for Permit

    Science.gov (United States)

    2010-12-03

    ... Species Applicant: International Elephant Foundation, Fort Worth, TX; PRT- 15923A On October 25, 2010, we... applicant requests a permit to import biological specimens of Asian elephant (Elephus maximus) from wild... scientific research. This notification covers activities to be conducted by the applicant over a 5-year...

  8. Download this PDF file

    African Journals Online (AJOL)

    prt1sence . of viruses,' bacteria, -fi!ngi·-· and mycoplasma, (Lange et al:;\\ ... CMV in desiccated leaf tissues were received from the Danish Institute for ... sterilized Forrest soil. The pots were maintained in the greenhouse at 25-35°C under natural light until maturity. For BYMV, 40 healthy bean seedlings. 51 were inoculated ...

  9. MORPHOLOGICAL REPRESENTATION AND SEMANTIC ...

    African Journals Online (AJOL)

    The present paper deals with the question of whether the Compositionality. Condition can be ... Selkirk's rule for assigning grammatical functions to the nonhead of .... the meaning of Godel numbering is strictly compositional, a simple ... ennoble, encase), and (ii) nouns of the form V P which are headless ..... *v --> her Prt.

  10. Construction and maintenance of SUNY facilities at the National Synchrotron Light Source. Progress report, 1 July 1982-1 July 1983

    International Nuclear Information System (INIS)

    Bigeleisen, J.

    1983-01-01

    Experimental facilities on the X-21 beam line at the National Synchrotron Light Source are described, and synchrotron radiation experiments performed by PRT members are discussed. The report includes a description of the beam line development stages and the experimental equipment

  11. Neural Mechanisms of Improvements in Social Motivation after Pivotal Response Treatment: Two Case Studies

    Science.gov (United States)

    Voos, Avery C.; Pelphrey, Kevin A.; Tirrell, Jonathan; Bolling, Danielle Z.; Vander Wyk, Brent; Kaiser, Martha D.; McPartland, James C.; Volkmar, Fred R.; Ventola, Pamela

    2013-01-01

    Pivotal response treatment (PRT) is an empirically validated behavioral treatment that has widespread positive effects on communication, behavior, and social skills in young children with autism spectrum disorder (ASD). For the first time, functional magnetic resonance imaging was used to identify the neural correlates of successful response to…

  12. Dicty_cDB: SHA389 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available equence. 34 0.12 3 CR044130 |CR044130.1 Forward strand read from insert in 3'HPRT insertion targeting and chromosome engineering...PRT insertion targeting and chromosome engineering clone MHPP142o16. 50 0.13 1 CR...034434 |CR034434.1 Forward strand read from insert in 3'HPRT insertion targeting and chromosome engineering

  13. The influence of passenger flow on the topology characteristics of urban rail transit networks

    Science.gov (United States)

    Hu, Yingyue; Chen, Feng; Chen, Peiwen; Tan, Yurong

    2017-05-01

    Current researches on the network characteristics of metro networks are generally carried out on topology networks without passenger flows running on it, thus more complex features of the networks with ridership loaded on it cannot be captured. In this study, we incorporated the load of metro networks, passenger volume, into the exploration of network features. Thus, the network can be examined in the context of operation, which is the ultimate purpose of the existence of a metro network. To this end, section load was selected as an edge weight to demonstrate the influence of ridership on the network, and a weighted calculation method for complex network indicators and robustness were proposed to capture the unique behaviors of a metro network with passengers flowing in it. The proposed method was applied on Beijing Subway. Firstly, the passenger volume in terms of daily origin and destination matrix was extracted from exhausted transit smart card data. Using the established approach and the matrix as weighting, common indicators of complex network including clustering coefficient, betweenness and degree were calculated, and network robustness were evaluated under potential attacks. The results were further compared to that of unweighted networks, and it suggests indicators of the network with consideration of passenger volumes differ from that without ridership to some extent, and networks tend to be more vulnerable than that without load on it. The significance sequence for the stations can be changed. By introducing passenger flow weighting, actual operation status of the network can be reflected more accurately. It is beneficial to determine the crucial stations and make precautionary measures for the entire network’s operation security.

  14. Toronto smog report card 2003 : final grade C -

    International Nuclear Information System (INIS)

    2003-10-01

    An annual Smog Report Card for Toronto has been published annually by the Toronto Environmental Alliance since 1997, evaluating the progress made by the City toward reducing the environmental and health impacts of smog. The final grade for the City in 2003 was a C -, an improvement over last year's D +. The evaluation examined the performance on 33 initiatives in six major areas: leadership, transit, electricity, fleets and fuels, bikes and pedestrians, and public education. Issues that stood out were: a $30 million increase in funding to the Toronto Transit Commission (TTC), and the release of the TTC's Ridership Growth Strategy depicting how transit ridership can be increased through improved service and lower fares. The drive-through and pesticide by-laws were passed by Council, which should result in smog reduction from unnecessary activities. Leadership was found to be lacking at City Hall in the area of clean air, in view of its decision to proceed with the expansion of Island Airport. The decision to move forward on only 20 per cent of planned green power and energy efficiency measures was a low point in 2002. The City's budget process, which effectively screened out most environmental initiatives was in part responsible for the lack of progress. The following grades were awarded: transit and trip reduction (B), energy efficiency and green power received (D), fleets and fuels (C), bikes and pedestrians (C), public education (B). Recommendations for next year included: implementation of the TTC's Ridership Growth Strategy; creation of a Smog Plan Implementation Fund of $20 million per year to invest in energy efficiency, green fleets, green power and other related measures; and stop the expansion of Island Airport

  15. Prophylactic lower para-aortic irradiation using intensity-modulated radiotherapy mitigates the risk of para-aortic recurrence in locally advanced cervical cancer: A 10-year institutional experience.

    Science.gov (United States)

    Lee, Jie; Lin, Jhen-Bin; Chang, Chih-Long; Jan, Ya-Ting; Sun, Fang-Ju; Wu, Meng-Hao; Chen, Yu-Jen

    2017-07-01

    To evaluate the effects of prophylactic sub-renal vein radiotherapy (SRVRT) using intensity-modulated radiotherapy (IMRT) for cervical cancer. A total of 206 patients with FIGO stage IB2-IVA cervical cancer and negative para-aortic lymph nodes (PALNs) who underwent pelvic IMRT (PRT) or SRVRT between 2004 and 2013 at our institution were reviewed. SRVRT cranially extended the PRT field for PALNs up to the left renal vein level. The prescribed dose was consistent 50.4Gy in 28 fractions. Overall, 110 and 96 patients underwent PRT and SRVRT, respectively. The SRVRT group had more advanced disease based on FIGO stage and positive pelvic lymph nodes (PLNs). The median follow-up time was 60months (range, 7-143). For the total study population, the 5-year PALN recurrence-free survival (PARFS) and overall survival (OS) for PRT vs. SRVRT were 87.6% vs. 97.9% (p=0.03) and 74.5% vs. 87.8% (p=0.04), respectively. In patients with FIGO III-IVA or positive PLNs, the 5-year PARFS and OS for PRT vs. SRVRT were 80.1% vs. 96.4% (p=0.02) and 58.1% vs. 83.5% (p=0.012), respectively. However, there were no significant differences in these outcomes for patients with FIGO IB-IIB and negative PLNs. In a multivariate analysis, only SRVRT was associated with better PARFS (HR, 0.21; 95% CI, 0.06-0.78; p=0.02). The SRVRT did not significantly increase severe late toxicities. Prophylactic SRVRT using IMRT reduced PALN recurrence with tolerable toxicities, supporting the application of risk-based radiation fields for cervical cancer. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Controlled comparison of family cognitive behavioral therapy and psychoeducation/relaxation training for child obsessive-compulsive disorder.

    Science.gov (United States)

    Piacentini, John; Bergman, R Lindsey; Chang, Susanna; Langley, Audra; Peris, Tara; Wood, Jeffrey J; McCracken, James

    2011-11-01

    To examine the efficacy of exposure-based cognitive-behavioral therapy (CBT) plus a structured family intervention (FCBT) versus psychoeducation plus relaxation training (PRT) for reducing symptom severity, functional impairment, and family accommodation in youths with obsessive-compulsive disorder (OCD). A total of 71 youngsters 8 to 17 years of age (mean 12.2 years; range, 8-17 years, 37% male, 78% Caucasian) with primary OCD were randomized (70:30) to 12 sessions over 14 weeks of FCBT or PRT. Blind raters assessed outcomes with responders followed for 6 months to assess treatment durability. FCBT led to significantly higher response rates than PRT in ITT (57.1% vs 27.3%) and completer analyses (68.3% vs. 35.3%). Using HLM, FCBT was associated with significantly greater change in OCD severity and child-reported functional impairment than PRT and marginally greater change in parent-reported accommodation of symptoms. These findings were confirmed in some, but not all, secondary analyses. Clinical remission rates were 42.5% for FCBT versus 17.6% for PRT. Reduction in family accommodation temporally preceded improvement in OCD for both groups and child functional status for FCBT only. Treatment gains were maintained at 6 months. FCBT is effective for reducing OCD severity and impairment. Importantly, treatment also reduced parent-reported involvement in symptoms with reduced accommodation preceding reduced symptom severity and functional impairment. CLINICAL TRIALS REGISTRY INFORMATION: Behavior Therapy for Children and Adolescents with Obsessive-Compulsive Disorder (OCD); http://www.clinicaltrials.gov; NCT00000386. Copyright © 2011 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

  17. THE INFLUENCE OF BALL VELOCITY AND COURT ILLUMINATION ON REACTION TIME FOR TENNIS VOLLEY

    Directory of Open Access Journals (Sweden)

    Jui-hung Tu

    2010-03-01

    Full Text Available The he purpose of this study is to examine the effects of ball velocity, court illumination, and volley type on the reaction time (RT of a tennis athlete for a volley stroke. Eights cases with two different ball velocities (high and low, two volley types (forehand and backhand and two court illumination levels (dark and bright were studied. The 30 participating subjects consisted of 18 male and 12 female college tennis athletes (age: 24 ± 3.2 yr, with a United States Tennis Association (USTA ranking above 2.5. In order to ensure the validity of real-world correlations, the experiments were designed to simulate real competition situations. Reaction times were measured for volley strokes in response to different approaching ball velocities (high: 25.05 ± 0.37 m/s and low: 17.56 ± 0.92 m·s-1 for several volley types (forehand and backhand and court illumination levels (55649 ± 4292 lux and 363.24 ± 6.53 lux on the court. During the tests, the signals from an electromyogram sensor and a 3-axis accelerometer (± 50 g were recorded using an NI DAQ card (NI PXI-6251 and then analyzed to determine reaction time (RT, premotor reaction time (PRT, and motor reaction time (MRT through the LabVIEW system. Subsequent 3-way ANOVA analysis indicated no RT, PRT, or MRT interaction between ball velocity, volley type and illumination. The ball velocity and illumination parameters did affect RT and PRT values significantly with p < 0.05, no significant variation in MRT was observed across any implemented experimental conditions. All experimental results indicate that ball velocity and illumination levels strongly affect the value of PRT, but have no significant effect on the value of MRT, the changes in RT were dominated by PRT

  18. WE-D-BRE-03: Late Toxicity Following Photon Or Proton Radiotherapy in Patients with Brain Tumors

    Energy Technology Data Exchange (ETDEWEB)

    Munbodh, R; Ding, X; Yin, L; Anamalayil, S; Dorsey, J; Lustig, R; Alonso-Basanta, M [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States)

    2014-06-15

    Purpose: To identify indicators of Late Grade 3 (LG3) toxicity, late vision and hearing changes in patients treated for primary brain tumors with photon (XRT) or proton radiotherapy (PRT). Methods: We retrospectively reviewed 102 patients who received brain XRT or PRT to doses of 54 or 59.6 Gy in daily fractions of 1.8–2 Gy. Of the 80 patients (34 XRT, 39 PRT and 7 both modalities) reviewed for indicators of LG3 toxicity, 25 developed LG3 toxicity 90 to 500 days after radiotherapy completion. 55 patients had less than LG3 toxicity > 500 days after treatment. In that time, late vision and hearing changes were seen in 44 of 75 and 25 of 78 patients, respectively. The correlation between late toxicity and prescription dose, planning target volume (PTV) size, and doses to the brainstem, brain, optic chiasm, optic nerves, eyes and cochlea was evaluated. A two-tailed Fisher's exact test and Wilcoxon rank sum test were used for the statistical analysis for XRT, PRT and all patients combined. Results: Exceeding the 54 Gy-5% dose-volume brainstem constraint, but not the optic structure constraints, was significantly correlated (p < 0.05) with late vision changes in all three groups. Exceeding maximum and mean cochlear doses of 45 and 30 Gy, respectively, was a significant indicator of hearing changes (p < 0.05) in PRT patients and all patients combined. In a sub-group of 52 patients in whom the brain was contoured, the absolute brain volume receiving ≤ 50 Gy and > 60 Gy was significantly larger in patients with LG3 toxicity for all patients combined (p < 0.05). Prescription dose, brainstem dose and PTV volume were not correlated to LG3 toxicity. Conclusion: Our results indicate the importance of minimizing the brain volume irradiated, and brainstem and cochlea doses to reduce the risk of late toxicities following brain radiotherapy.

  19. The Prognostic Value of Hemoglobin Concentration in Postoperative Radiotherapy of 835 Patients With Laryngeal Cancer

    International Nuclear Information System (INIS)

    Rutkowski, Tomasz; Suwinski, Rafal; Idasiak, Adam

    2007-01-01

    Purpose: To investigate the prognostic value of hemoglobin (Hb) concentration in patients with laryngeal cancer treated with postoperative radiotherapy (pRT). Methods and Materials: The records of 835 patients who underwent pRT between 1980 and 2003 were reviewed. Most patients (526 of 835 patients; 63%) were in advanced clinical stages (T3-T4) and 371 of 835 patients (44%) were node positive. Total laryngectomy had been performed in 676 of 835 patients (81%). Median Hb concentration before (Hb0) and after pRT (Hb1) was the same (13.3 g/dl). However, individual differences between Hb1 and Hb0 (dHb) varied within a broad range (-8.8; 5.0 g/dl). Univariate and multivariate analyses were performed to identify variables significantly associated with locoregional control (LRC), metastases-free survival, and overall survival. Results: Patients with dHb greater than 0 had significantly improved 5-year LRC compared with those with dHb of 0 or less (80% vs. 72%, p = 0.01). Conversely, when categorized, neither Hb0 nor Hb1 had a significant influence on LRC. In multivariate analysis, dHb remained a prognostic factor for LRC (p = 0.01) among the other variables, which included overall radiation treatment time and nodal status. None of the Hb-related variables significantly influenced metastases-free or overall survival. Conclusion: Individual change in Hb concentration during the course of pRT (dHb) rather than Hb level before or after pRT appeared as an independent prognostic factor for LRC in this set of patients

  20. Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.

    Science.gov (United States)

    Kim, Yun-Hee; Kim, Kyung Tae; Lee, Sang-Jin; Hong, Seung-Hee; Moon, Ju Young; Yoon, Eun Kyung; Kim, Sukyoung; Kim, Eun Ok; Kang, Se Hun; Kim, Seok Ki; Choi, Sun Il; Goh, Sung Ho; Kim, Daehong; Lee, Seong-Wook; Ju, Mi Ha; Jeong, Jin Sook; Kim, In-Hoo

    2016-01-01

    Trans-splicing ribozyme enables to sense and reprogram target RNA into therapeutic transgene and thereby becomes a good sensing device for detection of cancer cells, judging from transgene expression. Previously we proposed PEPCK-Rz-HSVtk (PRT), hTERT targeting trans-splicing ribozyme (Rz) driven by liver-specific promoter phosphoenolpyruvate carboxykinase (PEPCK) with downstream suicide gene, herpes simplex virus thymidine kinase (HSVtk) for hepatocellular carcinoma (HCC) gene therapy. Here, we describe success of a re-engineered adenoviral vector harboring PRT in obtaining greater antitumor activity with less off-target effect for clinical application as a theranostics. We introduced liver-selective apolipoprotein E (ApoE) enhancer to the distal region of PRT unit to augment activity and liver selectivity of PEPCK promoter, and achieved better transduction into liver cancer cells by replacement of serotype 35 fiber knob on additional E4orf1-4 deletion of E1&E3-deleted serotype 5 back bone. We demonstrated that our refined adenovirus harboring PEPCK/ApoE-Rz-HSVtk (Ad-PRT-E) achieved great anti-tumor efficacy and improved ability to specifically target HCC without damaging normal hepatocytes. We also showed noninvasive imaging modalities were successfully employed to monitor both how well a therapeutic gene (HSVtk) was expressed inside tumor and how effectively a gene therapy took an action in terms of tumor growth. Collectively, this study suggests that the advanced therapeutic adenoviruses Ad-PRT-E and its image-aided evaluation system may lead to the powerful strategy for successful clinical translation and the development of clinical protocols for HCC therapy.

  1. Two Paralogous Families of a Two-Gene Subtilisin Operon Are Widely Distributed in Oral Treponemes

    Science.gov (United States)

    Correia, Frederick F.; Plummer, Alvin R.; Ellen, Richard P.; Wyss, Chris; Boches, Susan K.; Galvin, Jamie L.; Paster, Bruce J.; Dewhirst, Floyd E.

    2003-01-01

    Certain oral treponemes express a highly proteolytic phenotype and have been associated with periodontal diseases. The periodontal pathogen Treponema denticola produces dentilisin, a serine protease of the subtilisin family. The two-gene operon prcA-prtP is required for expression of active dentilisin (PrtP), a putative lipoprotein attached to the treponeme's outer membrane or sheath. The purpose of this study was to examine the diversity and structure of treponemal subtilisin-like proteases in order to better understand their distribution and function. The complete sequences of five prcA-prtP operons were determined for Treponema lecithinolyticum, “Treponema vincentii,” and two canine species. Partial operon sequences were obtained for T. socranskii subsp. 04 as well as 450- to 1,000-base fragments of prtP genes from four additional treponeme strains. Phylogenetic analysis demonstrated that the sequences fall into two paralogous families. The first family includes the sequence from T. denticola. Treponemes possessing this operon family express chymotrypsin-like protease activity and can cleave the substrate N-succinyl-alanyl-alanyl-prolyl-phenylalanine-p-nitroanilide (SAAPFNA). Treponemes possessing the second paralog family do not possess chymotrypsin-like activity or cleave SAAPFNA. Despite examination of a range of protein and peptide substrates, the specificity of the second protease family remains unknown. Each of the fully sequenced prcA and prtP genes contains a 5′ hydrophobic leader sequence with a treponeme lipobox. The two paralogous families of treponeme subtilisins represent a new subgroup within the subtilisin family of proteases and are the only subtilisin lipoprotein family. The present study demonstrated that the subtilisin paralogs comprising a two-gene operon are widely distributed among treponemes. PMID:14617650

  2. Comparison of the effectiveness of resistance training in women with chronic computer-related neck pain: a randomized controlled study.

    Science.gov (United States)

    Li, Xiao; Lin, Caina; Liu, Cuicui; Ke, Songjian; Wan, Qing; Luo, Haijie; Huang, Zhuxi; Xin, Wenjun; Ma, Chao; Wu, Shaoling

    2017-10-01

    Chronic computer-related neck pain is common among office workers. Studies have proposed neck strengthening exercise as a therapy to pain relieving and function improvement. The aim of this study was to compare the efficacy of different loading resistance trainings and we hypothesized that women with work-related neck pain could benefit more from progressive resistance training for pain and function recovery. A randomized controlled trial was conducted and subjects characterized by monotonous jobs were recruited. One hundred and nine employed women with chronic neck pain were randomly allocated into three groups, namely, progressive resistance training (PRT), fixed resistance training (FRT), and control group (CG). In PRT and FRT, four exercises for neck muscles with an elastic rubber band were performed on regular basis for 6 weeks. The therapeutic effectiveness was then evaluated at pretreatment, 2, 4, and 6 weeks during training period, and 3-month posttreatment. Assessment tools included visual analog scale (VAS), Neck Disability Index (NDI), pressure pain threshold (PPT), and maximal isometric neck strength. The outcomes were significantly better in PRT and FRT than those in CG at 6-week timepoint and 3-month follow-up (p = 0.000), in terms of VAS, NDI, PPT, and neck muscle strength. Besides, there were statistically significant decreases observed in VAS scores of PRT group compared with those in FRT at 4-, 6-week timepoints, and 3-month follow-up (p training was an effective method for pain relieving, mobility improving, pain threshold, and neck muscle strength enhancing in women with chronic computer-related neck pain. Thus, our study provided evidence that women with work-related neck pain might benefit more from PRT, which may have important implications for future clinical practice. The study was qualified and registered in the Chinese Clinical Trial Registry as ChiCTR-TRC-12002723.

  3. Effects of new bus and rail rapid transit systems – an international review

    DEFF Research Database (Denmark)

    Ingvardson, Jesper Bláfoss; Nielsen, Otto Anker

    2018-01-01

    areas surrounding the transit line with increasing property values. Such effects are traditionally associated with attractive rail-based public transport systems. However, a statistical comparison of 41 systems did not show significant deviations between effects on property values resulting from BRT...... time, ridership and modal shifts, and (ii) the indirect strategic effects in terms of effects on property values and urban development. The review confirms the existing literature suggesting that BRT can attract many passengers if travel time reductions are significantly high. This leads to attractive...

  4. Evaluation of 0 ≤ M ≤ 8 earthquake data sets in African – Asian region during 1966–2015

    Directory of Open Access Journals (Sweden)

    Theophilus Aanuoluwa Adagunodo

    2018-04-01

    Full Text Available This article evaluates the occurrence of 0 ≤ M ≤ 8 earthquake data sets for the period of 50 years (that is, January 1, 1966 to December 31, 2015 in African and Western Asia region. It is bounded by latitude 40° S to 40° N and longitude 30° W to 60° E with the focal depth of 0–700 km. Seventy seven thousand, six hundred and ninety-six data points were presented for the analysis. The data used were extracted from earthquake catalog of Advanced National Seismic system via http://quake.geo.berkeley.edu/cnss/, an official website of the Northern California Earthquake Data Centre, USA. Each datum comprised the earthquake occurrence date, time of the earthquake occurrence, epicenter’s coordinates, focal depth and magnitude. The Gutenberg-Richter’s relationship being the longest observed empirical relationship in seismology, analysis of variance and time series were used to analyze the seismicity of the study area. Annual distributions of earthquake occurrence based on magnitude variations with the limit 0 ≤ M ≤ 8 were presented. The two constants a and b in the Gutenberg-Richter’s equation, magnitude of completeness (MC adjusted R-Square and F-value for the period of 1966–1975, 1976–1985, 1986–1995, 1996–2005, 2006–2015, and the entire period of investigation ranging from 1966 to 2015 were determined so as to investigate the variations of these parameters on earthquake occurrence over time. The histograms of earthquake occurrence against magnitude of earthquakes for the selected years (1966–1975, 1976–1985, 1986–1995, 1996–2005, 2006–2015, and 1966–2015, and the decadal frequency distributions of earthquake occurrence were also plotted. The focal depth occurrence for each magnitude bins (0–0.9, 1–1.9, 2–2.9, 3–3.9, 4–4.9, 5–5.9, 6–6.9, 7–7.9, 8–8.9 were grouped into shallow, intermediate, and deep depths ranging from 0 to 70, 71 to 300, and 301 to 700 km as being used in seismology. The

  5. Historical and current atmospheric deposition to the epilithic lichen Xanthoparmelia in Maricopa County, Arizona

    Energy Technology Data Exchange (ETDEWEB)

    Zschau, T.; Getty, S.; Gries, C.; Ameron, Y.; Zambrano, A.; Nash, T.H

    2003-09-01

    Spatial variation of elemental deposition to lichen receptors across Maricopa County, Arizona, USA is documented for 1998 and historical trends relative to 1974 are documented. - Spatial patterns of atmospheric deposition of trace elements to an epilithic lichen were assessed using a spatial grid of 28 field sites in 1998 throughout Maricopa County, Arizona, USA. In addition, samples of Xanthoparmelia spp. from Arizona State University lichen herbarium material (1975-1976) was utilized for a limited number of sites in order to explore temporal trends. The lichen material was cleaned, wet digested and analyzed by ICP-MS for a suite of elemental concentrations [antimony (Sb), cadmium (Cd), cerium (Ce), chromium (Cr), cobalt (Co), copper (Cu), dysprosium (Dy), europium (Eu), gadolinium (Gd), gold (Au), holmium (Ho), lead (Pb), lutetium (Lu), neodymium (Nd), nickel (Ni), palladium (Pd), platinum (Pt), praseodymium (Pr), samarium (Sm), scandium (Sc), silver (Ag), terbium (Tb), thulium (Tm), tin (Sn), uranium (U), ytterbium (Yb), yttrium (Y), and zinc (Zn)]. Cluster analysis and principal component analysis suggest three major factors, which, depending on regional aerosol fractionation, explain most of the variation in elemental signatures: (1) a group of widely distributed rare earth elements (2) a highly homogenous Co, Cr, Ni, and Sc component representing the influence of mafic rocks, and (3) anthropogenic emissions. Elemental concentrations in Maricopa County lichens were generally comparable to those reported for relatively unpolluted areas. Only highly urbanized regions, such as the greater Phoenix Metropolitan Area and the NW corner of the county, exhibited elevated concentrations for Zn, Cu, Pb, and Cd. Lead levels in lichens have fallen over the last 30 years by 71%, while Zn concentrations for some regions have increased by as much as 245%. From the spatial pattern of elemental deposition for Cd, Cu, Ni, Pr, Pb, and Cu, we infer that agriculture, mining

  6. Some aspects of organic and inorganic particulate transport at Rocky Flats. Final report

    International Nuclear Information System (INIS)

    Nichols, H.

    Findings from the summer 1975 sampling program and the conclusions from the 1975-1976 winter sampling program are summarized. Large radionuclide particles were not found attached to pollen. Sampling the airborne pollen throughout the Rocky Flats area demonstrated that the Rocky Flats air samplers were deficient in their abilities to properly collect large lightweight pollen grains. This may not have serious consequences for the undetected transport of radionuclides by pollen, however, it has implications of sampling inefficiency in some particulate size ranges, and implies that if radionuclides are carried at times by larger particles, then the standard Rocky Flats air samplers are not sampling these materials efficiently. Some initial findings suggested that soil samples from downwind areas associated with winter snow accumulation had abnormally high fissile particle accumulations, and this suggested the need to sample these sites in winter. Areas of preferred particle accumulation such as snow banks had higher concentrations of radionuclide particles than surrounding areas which are more windswept. Any soil sampling program at Rocky Flats which seeks to monitor background radionuclide levels and movement of fissile particles across the site should take account of these topographically and wind-controlled accumulation areas, and not rely solely on a grid pattern of sampling. The snow samples contained radionuclide material in substantial quantities. In terms of fissile particulates smaller than 0.5 microns the snow banks three miles east of the plant site contained as much or more radionuclides than sites close to the Hot Spot contaminated area. The snow samples immediately east of the Hot Spot contained many more large particles (>0.5 m), as did soil samples from the upwind site next to the plant fence. The Hot Spot is clearly implicated again as the source of these materials

  7. Radionuclide distributions in sediment cores retrieved from marine radioactive waste dumpsites

    International Nuclear Information System (INIS)

    Bowen, V.T.; Livingston, H.D.

    1981-01-01

    The concentrations, distributions and inventories of 55 Fe, 60 Co, 137 Cs, 134 Cs, 238 Pu, sup(239,240)Pu, 241 Am, 244 Cm and 242 Cm were measured in sediment samples collected in 1975-1976 from some Atlantic and Pacific sites used by the United States of America from 1946-1970 to dump solidified radioactive waste. Criteria used to distinguish waste-contaminated sediments from fallout-contaminated sediments include deviations of nuclide concentrations, inventories, internuclide ratios and depth distributions. The detection of nuclides absent from fallout is a further indicator. The data set used in comparing dumpsite sediment radioactivity with non-dumpsite radioactivity comes from a population of 11 North Atlantic cores in the depth range 2000-4000 m. A further set of 19 cores from the central North Pacific provides an interesting contrast to the data set for the shallower sediments closer to the coasts. The principal conclusion drawn from consideration of a large body of data, especially for 15 sediment cores from the Atlantic dumpsite, is that contamination is extremely localized with respect to the sources from which the waste is believed to originate. The majority of cores from both dumpsites are indistinguishable from populations of cores contaminated only by world-wide fallout. Clearly, contaminated sediments from both dumpsites show evidence of the introduction of waste radioactivity below the sediment surface before subsequent redistribution by in-sediment processes. These findings have significance for the selection and monitoring of sites to be used in connection with the ocean disposal of radioactive waste. (author)

  8. Historical and current atmospheric deposition to the epilithic lichen Xanthoparmelia in Maricopa County, Arizona

    International Nuclear Information System (INIS)

    Zschau, T.; Getty, S.; Gries, C.; Ameron, Y.; Zambrano, A.; Nash, T.H.

    2003-01-01

    Spatial variation of elemental deposition to lichen receptors across Maricopa County, Arizona, USA is documented for 1998 and historical trends relative to 1974 are documented. - Spatial patterns of atmospheric deposition of trace elements to an epilithic lichen were assessed using a spatial grid of 28 field sites in 1998 throughout Maricopa County, Arizona, USA. In addition, samples of Xanthoparmelia spp. from Arizona State University lichen herbarium material (1975-1976) was utilized for a limited number of sites in order to explore temporal trends. The lichen material was cleaned, wet digested and analyzed by ICP-MS for a suite of elemental concentrations [antimony (Sb), cadmium (Cd), cerium (Ce), chromium (Cr), cobalt (Co), copper (Cu), dysprosium (Dy), europium (Eu), gadolinium (Gd), gold (Au), holmium (Ho), lead (Pb), lutetium (Lu), neodymium (Nd), nickel (Ni), palladium (Pd), platinum (Pt), praseodymium (Pr), samarium (Sm), scandium (Sc), silver (Ag), terbium (Tb), thulium (Tm), tin (Sn), uranium (U), ytterbium (Yb), yttrium (Y), and zinc (Zn)]. Cluster analysis and principal component analysis suggest three major factors, which, depending on regional aerosol fractionation, explain most of the variation in elemental signatures: (1) a group of widely distributed rare earth elements (2) a highly homogenous Co, Cr, Ni, and Sc component representing the influence of mafic rocks, and (3) anthropogenic emissions. Elemental concentrations in Maricopa County lichens were generally comparable to those reported for relatively unpolluted areas. Only highly urbanized regions, such as the greater Phoenix Metropolitan Area and the NW corner of the county, exhibited elevated concentrations for Zn, Cu, Pb, and Cd. Lead levels in lichens have fallen over the last 30 years by 71%, while Zn concentrations for some regions have increased by as much as 245%. From the spatial pattern of elemental deposition for Cd, Cu, Ni, Pr, Pb, and Cu, we infer that agriculture, mining

  9. Deep Structure of the Zone of Tolbachik Fissure Eruptions (Kamchatka, Klyuchevskoy Volcano Group): Evidence from a Complex of Geological and Geophysical Data

    Science.gov (United States)

    Kugaenko, Yu. A.; Saltykov, V. A.; Gorvatikov, A. V.; Stepanova, M. Yu.

    2018-05-01

    With the use of the method of low-frequency microseismic sounding, the configuration of the magmatic feeding system of the Tolbachinsky Dol—a regional zone of areal basaltic volcanism in the southern part of the Klyuchevskoy volcano group in Kamchatka—is studied. The initial data are obtained by a stepby-step recording of the background microseismic noise in 2010-2015 within a thoroughly marked-out survey area covering the zones of fissure eruptions in 1975-1976 and 2012-2013 and, partly, the edifice of the Ploskii (flat) Tolbachik volcano. The depth sections reflecting the distributions of the relative velocities of seismic waves in the Earth's crust are constructed. For a more reliable interpretation of the revealed deep anomalies, the results of independent geological and geophysical studies are used. The ascertained low-velocity structures are closely correlated to the manifestations of present-day volcanism. It is shown that the feeding structure of the Tolbachinsky Dol is spatially heterogeneous, incorporating subvertical and lateral pipeshaped magma conduits, closely spaced magma feeding channels, and shallow magma reservoirs. A longlived local transcrustal magma conducting zone is revealed, and regularities in the deep structure of the feeding systems of fissure eruptions are identified. The configuration of the established subvertical magma conduits permits basalts moving to rise to the surface by different paths, which, inter alia, explains the contrasting magma compositions observed during a single eruption. Thus, based on the instrumental data, it is shown that the magmatic feeding structure of the Tolbachinsky Dol has a number of specific peculiarities and is significantly more complicated than has been previously thought about the areal volcanic fields.

  10. Reward Learning, Neurocognition, Social Cognition, and Symptomatology in Psychosis.

    Science.gov (United States)

    Lewandowski, Kathryn E; Whitton, Alexis E; Pizzagalli, Diego A; Norris, Lesley A; Ongur, Dost; Hall, Mei-Hua

    2016-01-01

    Patients with psychosis spectrum disorders exhibit deficits in social and neurocognition, as well as hallmark abnormalities in motivation and reward processing. Aspects of reward processing may overlap behaviorally and neurobiologically with some elements of cognitive functioning, and abnormalities in these processes may share partially overlapping etiologies in patients. However, whether reward processing and cognition are associated across the psychoses and linked to state and trait clinical symptomatology is unclear. The present study examined associations between cognitive functioning, reward learning, and clinical symptomatology in a cross-diagnostic sample. Patients with schizophrenia (SZ; n = 37), bipolar I disorder with psychosis (BD; n = 42), and healthy controls (n = 29) were assessed for clinical symptoms (patients only), neurocognitive functioning using the MATRICS Battery (MCCB) and reward learning using the probabilistic reward task (PRT). Groups were compared on neurocognition and PRT response bias, and associations between PRT response bias and neurocognition or clinical symptoms were examined controlling for demographic variables and PRT task difficulty (discriminability). Patients with SZ performed worse than controls on most measures of neurocognition; patients with BD exhibited deficits in some domains between the level of patients with SZ and controls. The SZ - but not BD - group exhibited deficits in social cognition compared to controls. Patients and controls did not differ on PRT response bias, but did differ on PRT discriminability. Better response bias across the sample was associated with poorer social cognition, but not neurocognition; conversely, discriminability was associated with neurocognition but not social cognition. Symptoms of psychosis, particularly negative symptoms, were associated with poorer response bias across patient groups. Reward learning was associated with symptoms of psychosis - in particular negative

  11. Projected Second Tumor Risk and Dose to Neurocognitive Structures After Proton Versus Photon Radiotherapy for Benign Meningioma

    Energy Technology Data Exchange (ETDEWEB)

    Arvold, Nils D. [Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA (United States); Niemierko, Andrzej; Broussard, George P.; Adams, Judith; Fullerton, Barbara; Loeffler, Jay S. [Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA (United States); Shih, Helen A., E-mail: hshih@partners.org [Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA (United States)

    2012-07-15

    Purpose: To calculated projected second tumor rates and dose to organs at risk (OAR) in patients with benign intracranial meningioma (BM), according to dosimetric comparisons between proton radiotherapy (PRT) and photon radiotherapy (XRT) treatment plans. Methods and Materials: Ten patients with BM treated at Massachusetts General Hospital during 2006-2010 with PRT were replanned with XRT (intensity-modulated or three-dimensional conformal radiotherapy), optimizing dose to the tumor while sparing OAR. Total dose was 54 Gy in 1.8 Gy per fraction for all plans. We calculated equivalent uniform doses, normal tissue complication probabilities, and whole brain-based estimates of excess risk of radiation-associated intracranial second tumors. Results: Excess risk of second tumors was significantly lower among PRT compared with XRT plans (1.3 vs. 2.8 per 10,000 patients per year, p < 0.002). Mean equivalent uniform doses were lower among PRT plans for the whole brain (19.0 vs. 22.8 Gy, p < 0.0001), brainstem (23.8 vs. 35.2 Gy, p = 0.004), hippocampi (left, 13.5 vs. 25.6 Gy, p < 0.0001; right, 7.6 vs. 21.8 Gy, p = 0.001), temporal lobes (left, 25.8 vs. 34.6 Gy, p = 0.007; right, 25.8 vs. 32.9 Gy, p = 0.008), pituitary gland (29.2 vs. 37.0 Gy, p = 0.047), optic nerves (left, 28.5 vs. 33.8 Gy, p = 0.04; right, 25.1 vs. 31.1 Gy, p = 0.07), and cochleas (left, 12.2 vs. 15.8 Gy, p = 0.39; right,1.5 vs. 8.8 Gy, p = 0.01). Mean normal tissue complication probability was <1% for all structures and not significantly different between PRT and XRT plans. Conclusions: Compared with XRT, PRT for BM decreases the risk of RT-associated second tumors by half and delivers significantly lower doses to neurocognitive and critical structures of vision and hearing.

  12. Projected Second Tumor Risk and Dose to Neurocognitive Structures After Proton Versus Photon Radiotherapy for Benign Meningioma

    International Nuclear Information System (INIS)

    Arvold, Nils D.; Niemierko, Andrzej; Broussard, George P.; Adams, Judith; Fullerton, Barbara; Loeffler, Jay S.; Shih, Helen A.

    2012-01-01

    Purpose: To calculated projected second tumor rates and dose to organs at risk (OAR) in patients with benign intracranial meningioma (BM), according to dosimetric comparisons between proton radiotherapy (PRT) and photon radiotherapy (XRT) treatment plans. Methods and Materials: Ten patients with BM treated at Massachusetts General Hospital during 2006–2010 with PRT were replanned with XRT (intensity-modulated or three-dimensional conformal radiotherapy), optimizing dose to the tumor while sparing OAR. Total dose was 54 Gy in 1.8 Gy per fraction for all plans. We calculated equivalent uniform doses, normal tissue complication probabilities, and whole brain–based estimates of excess risk of radiation-associated intracranial second tumors. Results: Excess risk of second tumors was significantly lower among PRT compared with XRT plans (1.3 vs. 2.8 per 10,000 patients per year, p < 0.002). Mean equivalent uniform doses were lower among PRT plans for the whole brain (19.0 vs. 22.8 Gy, p < 0.0001), brainstem (23.8 vs. 35.2 Gy, p = 0.004), hippocampi (left, 13.5 vs. 25.6 Gy, p < 0.0001; right, 7.6 vs. 21.8 Gy, p = 0.001), temporal lobes (left, 25.8 vs. 34.6 Gy, p = 0.007; right, 25.8 vs. 32.9 Gy, p = 0.008), pituitary gland (29.2 vs. 37.0 Gy, p = 0.047), optic nerves (left, 28.5 vs. 33.8 Gy, p = 0.04; right, 25.1 vs. 31.1 Gy, p = 0.07), and cochleas (left, 12.2 vs. 15.8 Gy, p = 0.39; right,1.5 vs. 8.8 Gy, p = 0.01). Mean normal tissue complication probability was <1% for all structures and not significantly different between PRT and XRT plans. Conclusions: Compared with XRT, PRT for BM decreases the risk of RT-associated second tumors by half and delivers significantly lower doses to neurocognitive and critical structures of vision and hearing.

  13. Keberlanjutan Transportasi di Kota Surabaya Melalui Pengembangan Kawasan Berbasis TOD (Transit Oriented Development

    Directory of Open Access Journals (Sweden)

    Ketut Dewi Martha Erli Handayani

    2014-05-01

    Full Text Available Development plan of monorail and tramway in Surabaya City aimed to encourage the movement based transit. TOD (Transit Oriented Development is model for integration of transportation and land use in order to encourage the transit ridership. The result of study in worldwide show the success of TOD application in increasing the usage of transit mode by developing policies on land uses around station/terminal. Therefore, it needs to adopt TOD in transit area of Surabaya City to achieve the sustainable transportation. This study conclude criteria of TOD that can be applied in transit area of Surabaya City are mixed land uses, high intensity of activities around station/terminal, integrated design of circulation and road network, and pedestrians/cyclists friendly design.Development plan of monorail and tramway in Surabaya City aimed to encourage the movement based transit. TOD (Transit Oriented Development is model for integration of transportation and land use in order to encourage the transit ridership. The result of study in worldwide show the success of TOD application in increasing the usage of transit mode by developing policies on land uses around station/terminal. Therefore, it needs to adopt TOD in transit area of Surabaya City to achieve the sustainable transportation. This study conclude criteria of TOD that can be applied in transit area of Surabaya City are mixed land uses, high intensity of activities around station/terminal, integrated design of circulation and road network, and pedestrians/cyclists friendly design.

  14. A preliminary survey analysis of school shuttle bus system towards smart mobility solutions

    Science.gov (United States)

    Yue, Wong Seng; Hoy, Cheong Wan; Chye, Koh Keng

    2017-10-01

    Mobility and accessibility are crucial indicators of urban development. Public transport in the urban areas came into existence to fulfil transportation needs as well as mobility and accessibility demands. Ridership can be affected by the quality and quantity of transit service. However, technical improvements are needed for such as real-time bus information, controlling run time and headway delay. Thus, this paper is aimed to carry out a preliminary survey to determine the problems of school shuttle bus that faced by the students in a selected educational institution, their perceptions of using shuttle bus tracking and information mobile application and impacts of real-time information of public transits on bus ridership and towards smart mobility solutions. Efficient public transportation system needs further investigation about the role of mobile application for the bus tracking system in supporting smart mobility actions and real-time information. The proposed application also provides a smart solution for the management of public infrastructures and urban facilities in Malaysia in future. Eventually, this study opens an opportunity to improve Malaysian quality of life on the public value that created for the city as a whole.

  15. Transit Traffic Analysis Zone Delineating Method Based on Thiessen Polygon

    Directory of Open Access Journals (Sweden)

    Shuwei Wang

    2014-04-01

    Full Text Available A green transportation system composed of transit, busses and bicycles could be a significant in alleviating traffic congestion. However, the inaccuracy of current transit ridership forecasting methods is imposing a negative impact on the development of urban transit systems. Traffic Analysis Zone (TAZ delineating is a fundamental and essential step in ridership forecasting, existing delineating method in four-step models have some problems in reflecting the travel characteristics of urban transit. This paper aims to come up with a Transit Traffic Analysis Zone delineation method as supplement of traditional TAZs in transit service analysis. The deficiencies of current TAZ delineating methods were analyzed, and the requirements of Transit Traffic Analysis Zone (TTAZ were summarized. Considering these requirements, Thiessen Polygon was introduced into TTAZ delineating. In order to validate its feasibility, Beijing was then taken as an example to delineate TTAZs, followed by a spatial analysis of office buildings within a TTAZ and transit station departure passengers. Analysis result shows that the TTAZs based on Thiessen polygon could reflect the transit travel characteristic and is of in-depth research value.

  16. Palliative radiotherapy in head and neck cancers: Evidence based review

    Directory of Open Access Journals (Sweden)

    Talapatra Kaustav

    2006-01-01

    Full Text Available Squamous cell carcinoma of head and neck (SCCHN is one of the commonest cancers seen in India, constituting up to 25% of their overall cancer burden. Advanced SCCHN is a bad disease with a poor prognosis and patients usually die of uncontrolled loco-regional disease. Curative intent management of loco-regionally advanced SCCHN has become more evidence-based with active clinical research in the form of large prospective randomized controlled trials and meta-analyses. However, little has been written about palliative radiotherapy (PRT in head and neck cancers. It is widely recognized that PRT provides effective palliation and improved quality-of-life in advanced incurable malignancies. It is in this context that this study proposes to review the existing literature on palliative radiotherapy in advanced incurable SCCHN to help formulate consensus guidelines and recommendations.

  17. Synchronous Routing for Personal Rapid Transit Pods

    Directory of Open Access Journals (Sweden)

    Mehdi Mrad

    2014-01-01

    Full Text Available Personal rapid transit (PRT is a public and automated transport system in which a fleet of small driverless vehicles operate in order to transport passengers between a set of stations through a network of guided ways. Each customer is carried from one station to another directly with no stop in intermediate stations. This mode of transport can result in a high level of unused capacity due to the empty moves of the vehicles. In this paper, we model the problem of minimizing the energy consumed by the PRT system while assuming predeterministic list of orders; then we solve it using some constructive heuristics. Experiments are run on 1320 randomly generated test problems with various sizes. Our algorithms are shown to give good results over large trip instances.

  18. Increasing Opportunities for Question-Asking in School-Aged Children with Autism Spectrum Disorder: Effectiveness of Staff Training in Pivotal Response Treatment.

    Science.gov (United States)

    Verschuur, Rianne; Huskens, Bibi; Verhoeven, Ludo; Didden, Robert

    2017-02-01

    Deficits in question-asking are common in children with autism spectrum disorder (ASD). Furthermore, their opportunities to self-initiate questions are often hindered by directive behavior of their conversation partners. This study assessed the effectiveness of staff training in pivotal response treatment (PRT) on staff member-created opportunities and self-initiated questions of school-aged children with ASD. Generalization and maintenance were also assessed. Participants were 14 staff members and children with ASD attending an inpatient treatment facility. Data showed that PRT resulted in significant increases in both staff member-created opportunities and child-initiated questions. Generalization to group situations and collateral changes in children's language, pragmatic, and adaptive skills, and maladaptive behaviors did not occur. Implications for clinical practice and directions for future research are discussed.

  19. KWIK Smoke Obscuration Model: User’s Guide.

    Science.gov (United States)

    1982-09-01

    t ’ustr ( td I IK,j) 384: prt 3o :: pr t 6 k AC 1-4G" 36~b : pr t " ~ L 3b7: if j~i;prt &t(t1,] 3 8 8: it J=2;pr. "&str(Zjl,1,KI) 3 0 9: j~r t "I 39u...t.2~t71. * j3 3 2u: w r t 7uX ,"i(Lz~j i21iJ "c3wt70, )i: lnt 4 5X, "irI I U uIL - = 01 17.2;wrt 701,kq3 j~b: Lirt. 45x,"a..~c4 uAT - LiLY = g,t4.2

  20. Sharing the Burden? Assessing the Lithuanian Decision to Establish a Provincial Reconstruction Team in Afghanistan

    Directory of Open Access Journals (Sweden)

    Maskaliūnaitė Asta

    2014-12-01

    Full Text Available The paper assesses theories explaining the states’ burden-sharing decisions in an alliance and uses them to evaluate the Lithuanian decision to establish a Provincial Reconstruction Team (PRT in Afghanistan. In the literature, several influences on such decision-making are identified. These fall into two broad categories of systemic and domestic factors. From the former, threat perception, alliance dependence, systemic pressures of alliance politics are analysed; and from the latter three clusters of aspects such as: state autonomy, elite consensus, space of manoeuver of the executive; bureaucratic politics and organizational interests, and third, some additional elements of strategic culture/state identity. While most factors have some explanatory value, the analysis invites the conclusion that in case of the decision to lead a PRT, the two most important elements were alliance dependence from the first cluster and strategic culture and bureaucratic politics from the second.

  1. Intensity-modulated proton therapy, volumetric-modulated arc therapy, and 3D conformal radiotherapy in anaplastic astrocytoma and glioblastoma. A dosimetric comparison

    Energy Technology Data Exchange (ETDEWEB)

    Adeberg, S.; Debus, J. [Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg (Germany); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg (Germany); University Hospital Heidelberg, Department of Radiation Oncology, Heidelberg (Germany); German Cancer Research Center (DKFZ), Clinical Cooperation Unit Radiation Oncology, Heidelberg (Germany); Harrabi, S.B.; Bougatf, N.; Rieber, J.; Koerber, S.A.; Herfarth, K.; Rieken, S. [Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg (Germany); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg (Germany); University Hospital Heidelberg, Department of Radiation Oncology, Heidelberg (Germany); Bernhardt, D.; Syed, M.; Sprave, T.; Mohr, A. [Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg (Germany); University Hospital Heidelberg, Department of Radiation Oncology, Heidelberg (Germany); Abdollahi, A. [University Hospital Heidelberg, Department of Radiation Oncology, Heidelberg (Germany); Haberer, T. [Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg (Germany); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg (Germany); Combs, S.E. [Technische Universitaet Muenchen, Department of Radiation Oncology, Muenchen (Germany); Helmholtz Zentrum Muenchen, Institut fuer Innovative Radiotherapie (iRT), Department of Radiation Sciences (DRS), Neuherberg (Germany)

    2016-11-15

    The prognosis for high-grade glioma (HGG) patients is poor; thus, treatment-related side effects need to be minimized to conserve quality of life and functionality. Advanced techniques such as proton radiation therapy (PRT) and volumetric-modulated arc therapy (VMAT) may potentially further reduce the frequency and severity of radiogenic impairment. We retrospectively assessed 12 HGG patients who had undergone postoperative intensity-modulated proton therapy (IMPT). VMAT and 3D conformal radiotherapy (3D-CRT) plans were generated and optimized for comparison after contouring crucial neuronal structures important for neurogenesis and neurocognitive function. Integral dose (ID), homogeneity index (HI), and inhomogeneity coefficient (IC) were calculated from dose statistics. Toxicity data were evaluated. Target volume coverage was comparable for all three modalities. Compared to 3D-CRT and VMAT, PRT showed statistically significant reductions (p < 0.05) in mean dose to whole brain (-20.2 %, -22.7 %); supratentorial (-14.2 %, -20,8 %) and infratentorial (-91.0 %, -77.0 %) regions; brainstem (-67.6 %, -28.1 %); pituitary gland (-52.9 %, -52.5 %); contralateral hippocampus (-98.9 %, -98.7 %); and contralateral subventricular zone (-62.7 %, -66.7 %, respectively). Fatigue (91.7 %), radiation dermatitis (75.0 %), focal alopecia (100.0 %), nausea (41.7 %), cephalgia (58.3 %), and transient cerebral edema (16.7 %) were the most common acute toxicities. Essential dose reduction while maintaining equal target volume coverage was observed using PRT, particularly in contralaterally located critical neuronal structures, areas of neurogenesis, and structures of neurocognitive functions. These findings were supported by preliminary clinical results confirming the safety and feasibility of PRT in HGG. (orig.) [German] Die Prognose bei ''High-grade''-Gliomen (HGG) ist infaust. Gerade bei diesen Patienten sollten therapieassoziierte Nebenwirkungen minimiert werden

  2. A cost-effectiveness analysis of adjuvant therapies for resected adenocarcinoma of the rectum

    International Nuclear Information System (INIS)

    Lee, Jason H.

    1997-01-01

    PURPOSE: Several prospective randomized trials have shown a significant survival advantage with adjuvant chemotherapy and radiation therapy following surgical resection of adenocarcinoma of the rectum. Recent and ongoing trials are evaluating the role of modulated and/or protracted venous infusion [PVI] chemotherapy with pelvic irradiation [PRT]. The economic implications of additional therapies compared with their incremental benefits have not been rigorously analyzed. This study attempts to assess the incremental cost effectiveness of adjuvant therapy over surgery alone, and secondly, adjuvant therapy with PVI delivery systems versus rapid infusion. METHODS: A Markov model was constructed to describe the natural history of rectal carcinoma [stage B2, C] following surgical resection in a hypothetical cohort of 60 year old patients. This model was used to perform two sets of comparisons: [1] surgery alone versus adjuvant bolus fluorouracil [5-FU] with PRT, and [2] bolus 5-FU with PRT versus PVI 5-FU with PRT. Relapse rates and overall survival were derived from an early GITSG trial for the first comparison and from the NCCTG 86-47-51 trial for the second comparison. Medicare reimbursement rates and reports from health maintenance organizations were used to obtain net medical costs of adjuvant treatments, routine follow-up, advanced recurrent disease, and terminal illness as a result of rectal carcinoma. Total years of life and medical costs were projected over an 8-year time horizon for the first comparison [GITSG data] and over a 5-year time horizon for the second comparison [NCCTG data]. Monetary and nonmonetary benefits were discounted at 5% per year. Adjustments for quality of life, costs of adverse effects from treatment, and indirect costs of disease or treatment were not included in this current analysis. RESULTS: The main survival and economic outcomes for each treatment arm in the two comparisons are reported in the table below. For the first comparison

  3. Domestic Worker, Transnational Advocacy and the State of Exception: A Case Study on The Advocacy of Domestic Worker’s Rights in Indonesia

    Directory of Open Access Journals (Sweden)

    Gema Ramadhan Bastari

    2018-01-01

    Full Text Available This paper explains why domestic workers (PRT remain not considered as formal workers in Indonesia. This problem becomes very urgent as PRT covers 76% of the national labor population and there has been considerable pressure from transnational community. This question is answered by applying  Agamben's theory of state of exception. This paper deploysdiscourse analysis method to examine a number of texts related to the Government of Indonesian's stance and the advocacy for PRT’s rights in Indonesia. This study finds that the Government of Indonesia has established a state of exception allowing to ignore PRT’s rights as workers under existing law. The study, then, concludes that the Government of Indonesian cannot be expected to meet PRT’s rights. Consequently, the strategy of advocacy should be directed to encourage other countries to push Indonesia so as to meet PRT’s rights.

  4. Grid-connected vehicles as the core of future land-based transport systems

    International Nuclear Information System (INIS)

    Gilbert, Richard; Perl, Anthony

    2007-01-01

    Grid-connected vehicles (GCVs)-e.g., electric trains, metros, trams, and trolley buses-are propelled by electric motors directly connected to remote power sources. Their low at-vehicle energy consumption and ability to use a wide range of renewable energy sources make them strong contenders for urban and interurban transport systems in an era of energy constraints that favours use of renewable fuels, which may lie ahead. Needs for autonomous motorised mobility could be acceptably met in large measure by deployment of personal GCVs, also known as personal rapid transit (PRT). Alternatives, including fuel-cell vehicles and dual-drive vehicles fuelled with ethanol, will be less feasible. The 'car of the future' may not be an automobile so much as a PRT element of a comprehensive GCV-based system that offers at least as much utility and convenience as today's transport systems

  5. Progressive resistance training in head and neck cancer patients undergoing concomitant chemoradiotherapy

    DEFF Research Database (Denmark)

    Lonkvist, Camilla K; Vinther, Anders; Zerahn, Bo

    2017-01-01

    was feasibility measured as attendance to training sessions. Secondary endpoints included changes in functional performance, muscle strength, and body composition measured by Dual-energy X-ray Absorptiometry (DXA) scans. Furthermore, sarcomeric protein content, pentose phosphate pathway (PPP) activity......, and glycolysis were determined in muscle biopsies. Results: Twelve patients with p16 positive oropharyngeal cancer were enrolled. The primary endpoint was met with 9 of the 12 patients completing at least 25 of 36 planned training sessions. The mean attendance rate was 77%. Functional performance was maintained...... resistance training (PRT) program during CCRT is feasible in the clinical setting before planning initiation of a larger randomized study which is the long-term goal. Study design: Prospective pilot study. Methods: Twelve patients receiving CCRT were planned to attend a 12-week PRT program. Primary endpoint...

  6. Development of a platinum resistance thermometer on the silicon substrate for phase change studies

    International Nuclear Information System (INIS)

    Cai, Qingjun; Chen, Ya-Chi; Tsai, Chialun; DeNatale, Jeffrey F

    2012-01-01

    Resistance temperature detectors are commonly used measurement sensors in heat transfer studies. In many resistance temperature detectors, the platinum resistance thermometer (PRT) is chemically stable, has a wide temperature measurement range and possesses high measurement accuracy. In phase change studies of carbon nanotubes, bi-porous structures for microelectronic thermal management, 100 nm thick PRTs are developed on silicon substrates with 10 nm titanium adhesive to achieve precise and interface-free temperature measurements. After an annealing at 375 °C, the PRT samples are calibrated at a temperature range from 20 to 180 °C. Measurement hysteresis of temperature appears in thermal cycles. Electrical resistance tends to become low during all heating periods, which establishes the maximum measurement deviation of 10 °C. Experimental results from two different thin-film PRTs indicate that accurate and repeatable temperature measurements can be achieved by either reducing heating speed or using data in the cooling period. (paper)

  7. No exacerbation of knee joint pain and effusion following preoperative progressive resistance training in patients scheduled for total knee arthroplasty

    DEFF Research Database (Denmark)

    Skoffer, Birgit; Dalgas, Ulrik; Maribo, Thomas

    2017-01-01

    BACKGROUND: Preoperative progressive resistance training (PRT) is controversial in patients scheduled for total knee arthroplasty (TKA), because of the concern that it may exacerbate knee joint pain and effusion. OBJECTIVE: To examine if preoperative PRT initiated 5 weeks prior to TKA would 1......) exacerbate pain and knee effusion, 2) allow a progressively increased training load throughout the training period that would subsequently increase muscle strength. DESIGN: Secondary analyses from a randomized controlled trial. SETTING: University Hospital and a Regional Hospital. PATIENTS: Thirty patients...... OUTCOME MEASURES: Before and after each training session, knee joint pain rated on an 11-point scale, effusion assessed by measuring the knee joint circumference, and training load were recorded. The first and last training session were initiated by 1RM testing of unilateral leg press, knee extension...

  8. Publication bias in studies of an applied behavior-analytic intervention: an initial analysis.

    Science.gov (United States)

    Sham, Elyssa; Smith, Tristram

    2014-01-01

    Publication bias arises when studies with favorable results are more likely to be reported than are studies with null findings. If this bias occurs in studies with single-subject experimental designs(SSEDs) on applied behavior-analytic (ABA) interventions, it could lead to exaggerated estimates of intervention effects. Therefore, we conducted an initial test of bias by comparing effect sizes, measured by percentage of nonoverlapping data (PND), in published SSED studies (n=21) and unpublished dissertations (n=10) on 1 well-established intervention for children with autism, pivotal response treatment (PRT). Although published and unpublished studies had similar methodologies, the mean PND in published studies was 22% higher than in unpublished studies, 95% confidence interval (4%, 38%). Even when unpublished studies are included, PRT appeared to be effective (PNDM=62%). Nevertheless, the disparity between published and unpublished studies suggests a need for further assessment of publication bias in the ABA literature.

  9. Effect of early supervised progressive resistance training compared to unsupervised home-based exercise after fast-track total hip replacement applied to patients with preoperative functional limitations

    DEFF Research Database (Denmark)

    Mikkelsen, L R; Mechlenburg, I; Søballe, K

    2014-01-01

    OBJECTIVE: To examine if 2 weekly sessions of supervised progressive resistance training (PRT) in combination with 5 weekly sessions of unsupervised home-based exercise is more effective than 7 weekly sessions of unsupervised home-based exercise in improving leg-extension power of the operated leg...... 10 weeks after total hip replacement (THR) in patients with lower pre-operative function. METHOD: A total of 73 patients scheduled for THR were randomised (1:1) to intervention group (IG, home based exercise 5 days/week and PRT 2 days/week) or control group (CG, home based exercise 7 days...... of the operated leg, at the primary endpoint 10 weeks after surgery in THR patients with lower pre-operative function. TRIAL REGISTRATION: NCT01214954....

  10. Neuromuscular adaptations to long-term progressive resistance training translates to improved functional capacity for people with multiple sclerosis and is maintained at follow-up

    DEFF Research Database (Denmark)

    Kjolhede, T.; Vissing, K.; de Place, L.

    2015-01-01

    BACKGROUND: Progressive resistance training (PRT) is acknowledged to effectively improve muscle strength for people with multiple sclerosis (PwMS), but diverging results exist regarding whether such improvements translates to improved functional capacity, possibly relating to insufficient duration......: This study was a randomised controlled trial, with a training group and a waitlist group undergoing supervised PRT for 24 weeks initially or after 24 weeks of habitual lifestyle, respectively. Functional capacity, isometric muscle strength of knee extensors and flexors, neural drive and thigh muscle cross......-sectional area was measured at baseline, after 24 and 48 weeks. RESULTS: The training group significantly improved neuromuscular function of the knee extensors and flexors, which translated to improvements in functional capacity. Furthermore, the improved functional capacity was maintained after 24 weeks of self...

  11. Resistance training improves muscle strength and functional capacity in multiple sclerosis

    DEFF Research Database (Denmark)

    Dalgas, U; Stenager, E; Jakobsen, J

    2009-01-01

    strength and functional capacity in patients with multiple sclerosis, the effects persisting after 12 weeks of self-guided physical activity. Level of evidence: The present study provides level III evidence supporting the hypothesis that lower extremity progressive resistance training can improve muscle......OBJECTIVE: To test the hypothesis that lower extremity progressive resistance training (PRT) can improve muscle strength and functional capacity in patients with multiple sclerosis (MS) and to evaluate whether the improvements are maintained after the trial. METHODS: The present study was a 2-arm...... and was afterward encouraged to continue training. After the trial, the control group completed the PRT intervention. Both groups were tested before and after 12 weeks of the trial and at 24 weeks (follow-up), where isometric muscle strength of the knee extensors (KE MVC) and functional capacity (FS; combined score...

  12. The use of positive reinforcement in training zebra sharks (Stegostoma fasciatum).

    Science.gov (United States)

    Marranzino, Ashley

    2013-01-01

    Positive reinforcement training (PRT) was used on 4 adult zebra sharks, Stegostoma fasciatum, housed at the Downtown Aquarium, Denver, to determine the ability of zebra sharks to become desensitized to various stimuli associated with veterinary procedures. One male and 3 female sharks were trained for 12 weeks. As a result of PRT, all 4 zebra sharks were desensitized to staying within a closed holding tank off of the main exhibit, the presence of multiple trainers in the closed holding tank, and tactile stimulation. One of the 4 zebra sharks was also successfully desensitized to the presence of a stretcher being brought into the holding tank. All of these procedures are common in veterinary examinations, and it is hoped that desensitization to these stimuli will reduce the stress associated with examinations. The training accomplished has allowed for easier maintenance of the zebra sharks by the aquarium staff and an improvement in the care of the sharks.

  13. "Leaving it to chance"-Passive risk taking in everyday life

    Directory of Open Access Journals (Sweden)

    Ruty Keinan

    2012-11-01

    Full Text Available While risk research focuses on actions that put people at risk, this paper introduces the concept of ``passive risk''---risk brought on or magnified by inaction. We developed a scale measuring personal tendency for passive risk taking (PRT, validated it using a 150 undergraduate student sample, and obtained three factors indicating separate domains of passive risk taking: risk involving resources, medical risks and ethical risks. The scale has criterion validity, as it is correlated with reported passive risk taking in everyday life, and also has high test-retest reliability. While correlated with the DOSPERT scale, the PRT shows divergent validity from classic risk taking constructs like sensation seeking, and convergent validity with tendencies previously not linked to risk taking, such as procrastination and avoidance. The results indicate that passive risk is a separate and unique domain of risk taking, which merits further research to understand the cognitive and motivational mechanism perpetuating it.

  14. Operation Iraqi Freedom: Strategies, Approaches, Results, and Issues for Congress

    Science.gov (United States)

    2009-04-02

    Joost Hiltermann characterized the operations as “a fairly transparent partisan effort by the Supreme Council [ISCI] dressed in government uniforms to... poultry debate” of 2008. In mid-2008, as part of the search for sustainable economic activity, some military and PRT officials proposed supporting the...development of domestic poultry and egg farming. Some argued that such a business required relatively low start- up costs, and would provide both

  15. Erwinia carotovora extracellular proteases : characterization and role in soft rot

    OpenAIRE

    Kyöstiö, Sirkka R. M.

    1990-01-01

    Erwinia carotovora subsp. carotovora (Ecc) strain EC14, a Gram-negative bacterium, causes soft rot on several crops, including potato. Maceration of potato tuber tissue is caused by secreted pectolytic enzymes. Other cell-degrading enzymes may also have roles in pathogenesis, including cellulases, phospholipases, and protease(s). The objectives of this research were to (1) characterize Ecc extracellular protease (Prt) and (2) elucidate its role in potato soft rot. A gene enc...

  16. Challenges in Assessing Progress in Multifunctional Operations: Experiences from a Provincial Reconstruction Team in Afghanistan

    Science.gov (United States)

    2011-06-01

    these measures. Assessment of progress can thus be seen as a process consisting of monitoring and evaluation activities ( Sida , 2007). Input...limited integration and understanding between the Swedish Armed Forces and SIDA at the domestic interagency level. Four participants said that the...military and SIDA personnel had been sent to the PRT with different mandates, objectives and cultures, without practical instructions on how to

  17. Special Inspector General for Iraq Reconstruction

    Science.gov (United States)

    2008-10-30

    managing childhood illness, Acute Respiratory Infection (ARI), pneumonia, and diarrhea, as well as maternal and newborn care. Nearly 20,000 IDPs have...More than 100 participants from the Kirkuk Veterinary Syndicate will receive new textbooks, clinical manuals, stethoscopes , thermometers, obstetrics...The PRT reported this quarter that the province’s date palms are threatened by disease and insect infestation because of a lack of insecticides

  18. No Exacerbation of Knee Joint Pain and Effusion Following Preoperative Progressive Resistance Training in Patients Scheduled for Total Knee Arthroplasty: Secondary Analyses From a Randomized Controlled Trial.

    Science.gov (United States)

    Skoffer, Birgit; Dalgas, Ulrik; Maribo, Thomas; Søballe, Kjeld; Mechlenburg, Inger

    2017-11-09

    Preoperative progressive resistance training (PRT) is controversial in patients scheduled for total knee arthroplasty (TKA), because of the concern that it may exacerbate knee joint pain and effusion. To examine whether preoperative PRT initiated 5 weeks prior to TKA would exacerbate pain and knee effusion, and would allow a progressively increased training load throughout the training period that would subsequently increase muscle strength. Secondary analyses from a randomized controlled trial. University Hospital and a Regional Hospital. A total of 30 patients who were scheduled for TKA due to osteoarthritis and assigned as the intervention group. Patients underwent unilateral PRT (3 sessions per week). Exercise loading was 12 repetitions maximum (RM) with progression toward 8 RM. The training program consisted of 6 exercises performed unilaterally. Before and after each training session, knee joint pain was rated on an 11-point scale, effusion was assessed by measuring the knee joint circumference, and training load was recorded. The first and last training sessions were initiated by 1 RM testing of unilateral leg press, unilateral knee extension, and unilateral knee flexion. The median pain change score from before to after each training session was 0 at all training sessions. The average increase in knee joint effusion across the 12 training sessions was a mean 0.16 cm ± 0.23 cm. No consistent increase in knee joint effusion after training sessions during the training period was found (P = .21). Training load generally increased, and maximal muscle strength improved as follows: unilateral leg press: 18% ± 30% (P = .03); unilateral knee extension: 81% ± 156% (P knee flexion: 53% ± 57% (P knee joint pain and effusion, despite a substantial progression in loading and increased muscle strength. Concerns for side effects such as pain and effusion after PRT seem unfounded. To be determined. Copyright © 2017. Published by Elsevier Inc.

  19. Cigarette craving is associated with blunted reward processing in nicotine-dependent smokers.

    Science.gov (United States)

    Peechatka, Alyssa L; Whitton, Alexis E; Farmer, Stacey L; Pizzagalli, Diego A; Janes, Amy C

    2015-10-01

    Dysfunctional reward processing leading to the undervaluation of non-drug rewards is hypothesized to play a crucial role in nicotine dependence. However, it is unclear if blunted reward responsivity and the desire to use nicotine are directly linked after a brief period of abstinence. Such an association would suggest that individuals with reduced reward responsivity may be at increased risk to experience nicotine craving. Reward function was evaluated with a probabilistic reward task (PRT), which measures reward responsivity to monetary incentives. To identify whether smoking status influenced reward function, PRT performance was compared between non-depressed, nicotine-dependent smokers and non-smokers. Within smokers, correlations were conducted to determine if blunted reward responsivity on the PRT was associated with increased nicotine craving. Time since last nicotine exposure was standardized to 4h for all smokers. Smokers and non-smokers did not differ in reward responsivity on the PRT. However, within smokers, a significant negative correlation was found between reward responsivity and intensity of nicotine craving. The current findings show that, among smokers, the intensity of nicotine craving is linked to lower sensitivity to non-drug rewards. This finding is in line with prior theories that suggest reward dysfunction in some clinical populations (e.g., depressive disorders, schizophrenia) may facilitate nicotine use. The current study expands on such theories by indicating that sub-clinical variations in reward function are related to motivation for nicotine use. Identifying smokers who show blunted sensitivity to non-drug rewards may help guide treatments aimed at mitigating the motivation to smoke. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  20. Dynamics of Interagency Cooperation Process at Provincial Reconstruction Team in Operations ISAF and Enduring Freedom

    Science.gov (United States)

    2010-06-11

    products to review what is known already about the interagency cooperation process at PRT level in operations Enduring Freedom and ISAF. The...Patricia Thomson, A Framework for Success: International Intervention in Societies Emerging from Conflict, Leashing the Dogs of War U.S. Institute...in detail in Chapter 4, the authors reported the experiences of PRTs manned by Canada, Germany, Italy, Lithuania , UK and USA. Four sections cover the

  1. Peer Review and Reflective Teaching Practices: An Effective Mechanism for Quality Enhancement in Higher Education

    OpenAIRE

    Raj, Sony Jalarajan; Massey, Susan R.; Jose, Soumya

    2017-01-01

    Quality education and teacher accountability are predominant issues generating apprehension in higher education. Traditional methods of evaluation are giving way to more contemporary methods. One technique that is being implemented in many universities throughout the world that provides feedback and improves pedagogical approaches is a formative and collaborative process known as peer review of teaching (PRT). Review of the literature included 34 studies which identified five themes that offe...

  2. Incidence of CNS Injury for a Cohort of 111 Patients Treated With Proton Therapy for Medulloblastoma: LET and RBE Associations for Areas of Injury

    Energy Technology Data Exchange (ETDEWEB)

    Giantsoudi, Drosoula; Sethi, Roshan V. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Yeap, Beow Y. [Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts (United States); Eaton, Bree R. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Ebb, David H. [Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts (United States); Caruso, Paul A.; Rapalino, Otto [Department of Radiology (O.R.) at the Massachusetts General Hospital, Boston, Massachusetts (United States); Chen, Yen-Lin E.; Adams, Judith A.; Yock, Torunn I.; Tarbell, Nancy J.; Paganetti, Harald [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); MacDonald, Shannon M., E-mail: smacdonald@mgh.harvard.edu [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2016-05-01

    Background: Central nervous system (CNS) injury is a rare complication of radiation therapy for pediatric brain tumors, but its incidence with proton radiation therapy (PRT) is less well defined. Increased linear energy transfer (LET) and relative biological effectiveness (RBE) at the distal end of proton beams may influence this risk. We report the incidence of CNS injury in medulloblastoma patients treated with PRT and investigate correlations with LET and RBE values. Methods and Materials: We reviewed 111 consecutive patients treated with PRT for medulloblastoma between 2002 and 2011 and selected patients with clinical symptoms of CNS injury. Magnetic resonance imaging (MRI) findings for all patients were contoured on original planning scans (treatment change areas [TCA]). Dose and LET distributions were calculated for the treated plans using Monte Carlo system. RBE values were estimated based on LET-based published models. Results: At a median follow-up of 4.2 years, the 5-year cumulative incidence of CNS injury was 3.6% for any grade and 2.7% for grade 3+. Three of 4 symptomatic patients were treated with a whole posterior fossa boost. Eight of 10 defined TCAs had higher LET values than the target but statistically nonsignificant differences in RBE values (P=.12). Conclusions: Central nervous system and brainstem injury incidence for PRT in this series is similar to that reported for photon radiation therapy. The risk of CNS injury was higher for whole posterior fossa boost than for involved field. Although no clear correlation with RBE values was found, numbers were small and additional investigation is warranted to better determine the relationship between injury and LET.

  3. Radiotherapy does not cause increase psychological fatigue in prostate cancer patients: a prospective study

    International Nuclear Information System (INIS)

    Monga, Uma; Kerrigan, Anthony J.; Monga, Trilok N.

    1997-01-01

    Objectives: The origin of fatigue, a common symptom in cancer patients undergoing radiotherapy(RT), remains unresolved. The objectives of this study were to evaluate subjective fatigue in patients with localized prostate cancer utilizing validated instruments and to examine the relationship of fatigue with radiotherapy. Methods: Instruments used included: Piper Fatigue Scale (PFS), Beck Depression Inventory (BDI), Epworth Sleepiness Scale (ESS) and Functional Assessment of Cancer Therapy - Prostate (FACT-P). Patients are evaluated before radiation therapy (PRT), at 4 weeks' (RT4), at completion of RT (7-8 weeks, RTC) of radiotherapy, and at 4 weeks follow-up (RTF). Seventeen prostate cancer subjects with a mean age of 64.6 years (range 55-73) were assessed. Results: PRT median scores on BDI, PFS, ESS, FACT(G), and FACT (P) were 4.00, 2.41, 6.0, 94, and 130 respectively. No significant changes in these scores were noted at RT4, RTC and RTF. Significant negative relationship was noted between PFS and physical well being sub-scale of FACT (G) at PRT(r=-0.76), RTC(r=-0.58), and RTF(r=-0.86). On BDI, four subjects reported depressive symptoms PRT. Two of these four subjects also scored higher on PFS. However, no significant changes were noted on their BDI and PFS scores during the study. No other patients reported depressive symptoms during treatment. Conclusions: These findings indicate: (1) No significant change in the baseline scores of fatigue and psychological measures during radiotherapy. (2) Self reported fatigue is not common in our patient population. (3) A significant relationship exists between scores on PFS and Physical well being sub-scale of FACT (G). Relationship between PFS, FACT-P and psychological functioning, severity of disease and PSA levels will also be presented

  4. Reirradiation of Head and Neck Cancers With Proton Therapy: Outcomes and Analyses

    Energy Technology Data Exchange (ETDEWEB)

    Phan, Jack [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Sio, Terence T. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Oncology, Mayo Clinic, Scottsdale, Arizona (United States); Nguyen, Theresa P. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Takiar, Vinita [Department of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio (United States); Gunn, G. Brandon; Garden, Adam S.; Rosenthal, David I.; Fuller, Clifton D.; Morrison, William H.; Beadle, Beth; Ma, Dominic [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zafereo, Mark E. [Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hutcheson, Kate A. [Department of Speech Pathology University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kupferman, Michael E. [Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); William, William N. [Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Frank, Steven J., E-mail: sjfrank@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2016-09-01

    Purpose: Reirradiation of head and neck (H&N) cancer is a clinical challenge. Proton radiation therapy (PRT) offers dosimetric advantages for normal tissue sparing and may benefit previously irradiated patients. Here, we report our initial experience with the use of PRT for H&N reirradiation, with focus on clinical outcomes and toxicity. Methods and Materials: We retrospectively reviewed the records of patients who received H&N reirradiation with PRT from April 2011 through June 2015. Patients reirradiated with palliative intent or without prior documentation of H&N radiation therapy were excluded. Radiation-related toxicities were recorded according to the Common Terminology Criteria for Adverse Events Version 4.0. Results: The conditions of 60 patients were evaluated, with a median follow-up time of 13.6 months. Fifteen patients (25%) received passive scatter proton therapy (PSPT), and 45 (75%) received intensity modulated proton therapy (IMPT). Thirty-five patients (58%) received upfront surgery, and 44 (73%) received concurrent chemotherapy. The 1-year rates of locoregional failure–free survival, overall survival, progression-free survival, and distant metastasis–free survival were 68.4%, 83.8%, 60.1%, and 74.9%, respectively. Eighteen patients (30%) experienced acute grade 3 (G3) toxicity, and 13 (22%) required a feeding tube at the end of PRT. The 1-year rates of late G3 toxicity and feeding tube independence were 16.7% and 2.0%, respectively. Three patients may have died of reirradiation-related effects (1 acute and 2 late). Conclusions: Proton beam therapy can be a safe and effective curative reirradiation strategy, with acceptable rates of toxicity and durable disease control.

  5. Early Cognitive Outcomes Following Proton Radiation in Pediatric Patients With Brain and Central Nervous System Tumors

    International Nuclear Information System (INIS)

    Pulsifer, Margaret B.; Sethi, Roshan V.; Kuhlthau, Karen A.; MacDonald, Shannon M.; Tarbell, Nancy J.; Yock, Torunn I.

    2015-01-01

    Purpose: To report, from a longitudinal study, cognitive outcome in pediatric patients treated with proton radiation therapy (PRT) for central nervous system (CNS) tumors. Methods and Materials: Sixty patients receiving PRT for medulloblastoma (38.3%), gliomas (18.3%), craniopharyngioma (15.0%), ependymoma (11.7%), and other CNS tumors (16.7%) were administered age-appropriate measures of cognitive abilities at or near PRT initiation (baseline) and afterward (follow-up). Patients were aged ≥6 years at baseline to ensure consistency in neurocognitive measures. Results: Mean age was 12.3 years at baseline; mean follow-up interval was 2.5 years. Treatment included prior surgical resection (76.7%) and chemotherapy (61.7%). Proton radiation therapy included craniospinal irradiation (46.7%) and partial brain radiation (53.3%). At baseline, mean Wechsler Full Scale IQ was 104.6; means of all 4 Index scores were also in the average range. At follow-up, no significant change was observed in mean Wechsler Full Scale IQ, Verbal Comprehension, Perceptual Reasoning/Organization, or Working Memory. However, Processing Speed scores declined significantly (mean 5.2 points), with a significantly greater decline for subjects aged <12 years at baseline and those with the highest baseline scores. Cognitive outcome was not significantly related to gender, extent of radiation, radiation dose, tumor location, histology, socioeconomic status, chemotherapy, or history of surgical resection. Conclusions: Early cognitive outcomes after PRT for pediatric CNS tumors are encouraging, compared with published outcomes from photon radiation therapy

  6. Whole blood pathogen reduction technology and blood safety in sub-Saharan Africa: A systematic review with regional discussion

    OpenAIRE

    Nkohkwo, Asa?ah; Agbor, Gabriel; Asongalem, Emmanuel; Tagny, Claude; Asonganyi, Tazoacha

    2016-01-01

    Background: Despite vast improvements in transfusion services in sub-Saharan Africa over the last decade, there remain serious concerns on the safety and adequacy of the blood supply across the region. Objective: This review paper ascertains the role of pathogen reduction technology (PRT) in improving blood safety and supply adequacy in the region. Method: The state of blood safety in sub-Saharan Africa was reviewed. Meetings, seminars and correspondence were undertaken with key clinic...

  7. Evaluation of adherence and tolerability of prolonged-release tacrolimus (Advagraf™) in kidney transplant patients in Germany: A multicenter, noninterventional study.

    Science.gov (United States)

    Lehner, Lukas J; Reinke, Petra; Hörstrup, Jan H; Rath, Thomas; Suwelack, Barbara; Krämer, Bernhard K; Budde, Klemens; Banas, Bernhard

    2018-01-01

    This study assessed adherence to prolonged-release tacrolimus (PR-T)-based immunosuppression during routine maintenance of renal transplant recipients in Germany. Patients had received PR-T for ≥1 month at inclusion. Data were collected during four visits (V): baseline (V1), 6 (V2), 12 (V3), and 18 (V4) months. Composite primary endpoint: nonadherence at V4, defined as self-reported nonadherence on the Basel Assessment of Adherence with Immunosuppressive Medication Scale (BAASIS © ), investigator-rated nonadherence, and/or V4 tacrolimus trough level outside a predefined range. Secondary endpoints: individual BAASIS items, incidence of rejection, kidney function, and safety. Overall, 153 adult kidney recipients (mean [standard deviation] time post-transplant 5.8 [4.6] years) were included. Nonadherence was high at V4 (67.7% [95% confidence interval 58.9%, 75.6%]). Medication-taking adherence was 86.9% and 91.3% at V1 and V4, respectively; adherence to timing of medication intake was 58.2% and 58.3%, with little evidence of missed doses/drug holidays. Investigators rated adherence "good" in 85.6% of patients (V4). Two (1.3%) patients had acute rejection episodes. Kidney function remained stable (mean creatinine clearance, V1: 62.1 mL/min; V4: 65.3 mL/min). Investigators rated effectiveness of PR-T as "very good"/"good" in 91.5% of patients. Most patients (94.7%) found PR-T dosing more convenient than immediate-release tacrolimus. PR-T was well tolerated with high medication persistence. © 2017 The Authors. Clinical Transplantation Published by John Wiley & Sons Ltd.

  8. Reirradiation of Head and Neck Cancers With Proton Therapy: Outcomes and Analyses

    International Nuclear Information System (INIS)

    Phan, Jack; Sio, Terence T.; Nguyen, Theresa P.; Takiar, Vinita; Gunn, G. Brandon; Garden, Adam S.; Rosenthal, David I.; Fuller, Clifton D.; Morrison, William H.; Beadle, Beth; Ma, Dominic; Zafereo, Mark E.; Hutcheson, Kate A.; Kupferman, Michael E.; William, William N.; Frank, Steven J.

    2016-01-01

    Purpose: Reirradiation of head and neck (H&N) cancer is a clinical challenge. Proton radiation therapy (PRT) offers dosimetric advantages for normal tissue sparing and may benefit previously irradiated patients. Here, we report our initial experience with the use of PRT for H&N reirradiation, with focus on clinical outcomes and toxicity. Methods and Materials: We retrospectively reviewed the records of patients who received H&N reirradiation with PRT from April 2011 through June 2015. Patients reirradiated with palliative intent or without prior documentation of H&N radiation therapy were excluded. Radiation-related toxicities were recorded according to the Common Terminology Criteria for Adverse Events Version 4.0. Results: The conditions of 60 patients were evaluated, with a median follow-up time of 13.6 months. Fifteen patients (25%) received passive scatter proton therapy (PSPT), and 45 (75%) received intensity modulated proton therapy (IMPT). Thirty-five patients (58%) received upfront surgery, and 44 (73%) received concurrent chemotherapy. The 1-year rates of locoregional failure–free survival, overall survival, progression-free survival, and distant metastasis–free survival were 68.4%, 83.8%, 60.1%, and 74.9%, respectively. Eighteen patients (30%) experienced acute grade 3 (G3) toxicity, and 13 (22%) required a feeding tube at the end of PRT. The 1-year rates of late G3 toxicity and feeding tube independence were 16.7% and 2.0%, respectively. Three patients may have died of reirradiation-related effects (1 acute and 2 late). Conclusions: Proton beam therapy can be a safe and effective curative reirradiation strategy, with acceptable rates of toxicity and durable disease control.

  9. Accuracy and differential bias in copy number measurement of CCL3L1 in association studies with three auto-immune disorders

    Directory of Open Access Journals (Sweden)

    Carpenter Danielle

    2011-08-01

    Full Text Available Abstract Background Copy number variation (CNV contributes to the variation observed between individuals and can influence human disease progression, but the accurate measurement of individual copy numbers is technically challenging. In the work presented here we describe a modification to a previously described paralogue ratio test (PRT method for genotyping the CCL3L1/CCL4L1 copy variable region, which we use to ascertain CCL3L1/CCL4L1 copy number in 1581 European samples. As the products of CCL3L1 and CCL4L1 potentially play a role in autoimmunity we performed case control association studies with Crohn's disease, rheumatoid arthritis and psoriasis clinical cohorts. Results We evaluate the PRT methodology used, paying particular attention to accuracy and precision, and highlight the problems of differential bias in copy number measurements. Our PRT methods for measuring copy number were of sufficient precision to detect very slight but systematic differential bias between results from case and control DNA samples in one study. We find no evidence for an association between CCL3L1 copy number and Crohn's disease, rheumatoid arthritis or psoriasis. Conclusions Differential bias of this small magnitude, but applied systematically across large numbers of samples, would create a serious risk of false positive associations in copy number, if measured using methods of lower precision, or methods relying on single uncorroborated measurements. In this study the small differential bias detected by PRT in one sample set was resolved by a simple pre-treatment by restriction enzyme digestion.

  10. 2007 Stability, Security, Transition and Reconstruction Operations Conference

    Science.gov (United States)

    2007-11-28

    narcotics Foster sustainable economy U.S.PRT tasks Jalalabad June 2007 Who can respond to which challeges ? 2. Battlespace or Humanitarian Space...Education Integrated Interagency Stabilization and Reconstruction Training Plug and Play System Lessons Learned from the Field USAID NGOs World Bank ...World Bank , IMF? Expanding the Focus… At the US and NATO Strategic/Operational Level Enhanced/new structures and procedures to improve: Interaction

  11. The NATO Warsaw Summit: How to Strengthen Alliance Cohesion (Strategic Forum, Number 296)

    Science.gov (United States)

    2016-06-01

    notion of European disintegration—if it were to take hold—cannot have but the most profound im- plications for Alliance management. The rise of political...BEL SVN CAN DEU HRV NOR FRA ESP HUN GBR USA TUR DNK NLD CZE ROU PRT EST GRC LVA SVK LUX POL LTU Figure. NATO Defense Expenditure Data Source: Defence ...Danish Institute for International Studies, August 2015); Rainer L. Glatz and Martin Zapfe, NATO Defence Planning between Wales and Warsaw: Politico

  12. Incidence of CNS Injury for a Cohort of 111 Patients Treated With Proton Therapy for Medulloblastoma: LET and RBE Associations for Areas of Injury

    International Nuclear Information System (INIS)

    Giantsoudi, Drosoula; Sethi, Roshan V.; Yeap, Beow Y.; Eaton, Bree R.; Ebb, David H.; Caruso, Paul A.; Rapalino, Otto; Chen, Yen-Lin E.; Adams, Judith A.; Yock, Torunn I.; Tarbell, Nancy J.; Paganetti, Harald; MacDonald, Shannon M.

    2016-01-01

    Background: Central nervous system (CNS) injury is a rare complication of radiation therapy for pediatric brain tumors, but its incidence with proton radiation therapy (PRT) is less well defined. Increased linear energy transfer (LET) and relative biological effectiveness (RBE) at the distal end of proton beams may influence this risk. We report the incidence of CNS injury in medulloblastoma patients treated with PRT and investigate correlations with LET and RBE values. Methods and Materials: We reviewed 111 consecutive patients treated with PRT for medulloblastoma between 2002 and 2011 and selected patients with clinical symptoms of CNS injury. Magnetic resonance imaging (MRI) findings for all patients were contoured on original planning scans (treatment change areas [TCA]). Dose and LET distributions were calculated for the treated plans using Monte Carlo system. RBE values were estimated based on LET-based published models. Results: At a median follow-up of 4.2 years, the 5-year cumulative incidence of CNS injury was 3.6% for any grade and 2.7% for grade 3+. Three of 4 symptomatic patients were treated with a whole posterior fossa boost. Eight of 10 defined TCAs had higher LET values than the target but statistically nonsignificant differences in RBE values (P=.12). Conclusions: Central nervous system and brainstem injury incidence for PRT in this series is similar to that reported for photon radiation therapy. The risk of CNS injury was higher for whole posterior fossa boost than for involved field. Although no clear correlation with RBE values was found, numbers were small and additional investigation is warranted to better determine the relationship between injury and LET.

  13. Incidence of CNS Injury for a Cohort of 111 Patients Treated With Proton Therapy for Medulloblastoma: LET and RBE Associations for Areas of Injury.

    Science.gov (United States)

    Giantsoudi, Drosoula; Sethi, Roshan V; Yeap, Beow Y; Eaton, Bree R; Ebb, David H; Caruso, Paul A; Rapalino, Otto; Chen, Yen-Lin E; Adams, Judith A; Yock, Torunn I; Tarbell, Nancy J; Paganetti, Harald; MacDonald, Shannon M

    2016-05-01

    Central nervous system (CNS) injury is a rare complication of radiation therapy for pediatric brain tumors, but its incidence with proton radiation therapy (PRT) is less well defined. Increased linear energy transfer (LET) and relative biological effectiveness (RBE) at the distal end of proton beams may influence this risk. We report the incidence of CNS injury in medulloblastoma patients treated with PRT and investigate correlations with LET and RBE values. We reviewed 111 consecutive patients treated with PRT for medulloblastoma between 2002 and 2011 and selected patients with clinical symptoms of CNS injury. Magnetic resonance imaging (MRI) findings for all patients were contoured on original planning scans (treatment change areas [TCA]). Dose and LET distributions were calculated for the treated plans using Monte Carlo system. RBE values were estimated based on LET-based published models. At a median follow-up of 4.2 years, the 5-year cumulative incidence of CNS injury was 3.6% for any grade and 2.7% for grade 3+. Three of 4 symptomatic patients were treated with a whole posterior fossa boost. Eight of 10 defined TCAs had higher LET values than the target but statistically nonsignificant differences in RBE values (P=.12). Central nervous system and brainstem injury incidence for PRT in this series is similar to that reported for photon radiation therapy. The risk of CNS injury was higher for whole posterior fossa boost than for involved field. Although no clear correlation with RBE values was found, numbers were small and additional investigation is warranted to better determine the relationship between injury and LET. Published by Elsevier Inc.

  14. "Plan gubernamental de reinserción": una alternativa para la creación de empresas

    Directory of Open Access Journals (Sweden)

    Yaneth Prieto Forero

    2015-05-01

    Full Text Available RESUMEN Uno de los planes destacados en este artículo  es un acuerdo de paz realizados con los grupos subversivos, que trata de la búsqueda de paz. El gobierno Nacional y los grupos subversivos: M-19, el partido revolucionario de los trabajadores (PRT., el ejército popular de liberación  (EPL. y quintín Lame (QL han logrado llegar a acuerdos.

  15. Pathogen reduction of whole blood: utility and feasibility.

    Science.gov (United States)

    Allain, J-P; Goodrich, R

    2017-10-01

    To collect information on pathogen reduction applied to whole blood. Pathogen reduction (PR) of blood components has been developed over the past two decades, and pathogen-reduced fresh-frozen plasma and platelet concentrates are currently in clinical use. High cost and incomplete coverage of components make PR out of reach for low- and middle-income countries (LMIC). However, should PR become applicable to whole blood (WB), the main product transfused in sub-Saharan Africa, and be compatible with the preparation of clinically suitable components, cost would be minimised, and a range of safety measures in place at high cost in developed areas would become redundant. All articles called with "pathogen reduction", "pathogen inactivation" and "whole blood" were retrieved from Medline. References in articles were utilised. One such PR technology (PRT) applied to WB has been developed and has shown efficacious against viruses, bacteria and parasites in vitro; and has been able to inactivate nucleated blood cells whilst retaining the ability to prepare components with acceptable characteristics. The efficacy of this WB PRT has been demonstrated in vivo using the inactivation of Plasmodium falciparum as a model and showing a high degree of correlation between in vitro and in vivo data. Obtaining further evidence of efficacy on other suitable targets is warranted. Shortening of the process, which is currently around 50 min, or increasing the number of units simultaneously processed would be necessary to make PRT WB conducive to LMIC blood services' needs. Even if not 100% effective against agents that are present in high pathogen load titres, WB PRT could massively impact blood safety in LMIC by providing safer products at an affordable cost. © 2017 British Blood Transfusion Society.

  16. Three New Forms of Movement That Encourage Walkable Urban Designs

    OpenAIRE

    McDonald, Shannon-Sanders

    2010-01-01

    New movement technology is currently becoming reality around the world. PRT (Personal Rapid Transit) now sometimes called ATN (Automated Transit Network) is currently available at Heathrow airport with systems in various planning stages in South Korea, San Jose, CA -Sam Mineta Airport, and Abu Dhabi, United Arab Emirates - Mazdar City. Technology that allows elevators to move three-dimensionally is currently applied in the Tower of Terror ride at Disneyland, Anaheim, CA. New automobiles are a...

  17. Palliative Radiotherapy in the Presence of Well-Controlled Metastatic Disease after Initial Chemotherapy May Prolong Survival in Patients with Metastatic Esophageal and Gastric Cancer.

    Science.gov (United States)

    Hingorani, Mohan; Dixit, Sanjay; Johnson, Miriam; Plested, Victoria; Alty, Kevin; Colley, Peter; Beavis, Andrew W; Roy, Rajarshi; Maraveyas, Anthony

    2015-10-01

    We report the outcomes of patients treated with palliative radiotherapy (pRT) to the primary tumour in the context of well-controlled metastatic disease after initial chemotherapy. Clinical records of 132 patients with metastatic esophago-gastric (OG) cancer treated with palliative chemotherapy (pCT) between January 2009 and June 2013 were reviewed. Ninetyseven patients had responding or stable disease after 3 months of chemotherapy, of whom 53 patients received pRT to the primary tumour after initial chemotherapy in the presence of well-controlled metastatic disease (group A, pCT-RT). The remaining 44 patients were treated with pCT alone (group B, pCT). Treatment-related outcomes were assessed in above groups including time to local progression (TTLP), progression-free and overall survival. The median overall survival for patients treated with pRT after initial chemotherapy (group A) was 23.3 months (95% confidence interval [CI], 17.70 to 28.89 months) and significantly higher than the 14 months (95% CI, 10.91 to 17.08 months) in patients treated with pCT alone (group B) (p < 0.001). The use of pCT-RT was an independent predictor of OS in multivariate analysis. Local recurrence was observed in 12/53 of patients (23%) in group A compared to 16/44 (36%) in group B. The median TTLP was significantly higher in patients after pCT-RT at 17.3 months (5.23 months to 44.50 months) compared to 8.3 months (range, 4.10 to 25.23 months) in patients treated with pCT alone (p=0.006). The possibility of pRT influencing systemic disease in advanced OG cancer has not been reported, and results from the present study present strong arguments for investigation of this therapeutic strategy in a randomized trial.

  18. Identificación molecular de mutaciones puntuales relacionadas con resistencia a drogas en VIH-1 de pacientes peruanos

    Directory of Open Access Journals (Sweden)

    Carlos Yabar V

    2006-07-01

    Full Text Available Objetivo: Identificar mutaciones puntuales relacionadas con resistencia a drogas en VIH-1 de pacientes peruanos. Materiales y metodos: Se seleccionaron 11 muestras de VIH provenientes de sangre total de sujetos con tratamiento antirretroviral (ARV. Posteriormente se realizo la optimizacion de la amplificacion de 337 pb del gen de la transcriptasa reversa (tr y 377 pb de todo el gen de la proteasa (prt. Los productos de PCR fueron secuenciados directamente para el analisis de mutaciones de resistencia. Las secuencias finales fueron analizadas en programas de analisis de mutaciones de la HIV Drug Resistance Database de la Universidad de Stanford. mutaciones de la HIV Drug Resistance Database de la Universidad de Stanford. Resultados: La optimizacion de la concentracion de ADN (2,5 ng / µL asi como la concentracion de magnesio (4 mM fueron factores criticos para la amplificacion de la tr y la prt respectivamente. De otro lado, el analisis de secuencia revelo la presencia de las mutaciones T215Y y la M184V en tr, implicadas en conferir resistencia a zidovudina (AZT y estavudina (D4T asi como a lamivudina (3TC y emtricitabina (FTC respectivamente. En prt se observaron las mutaciones D30N y N88D implicadas en conferir resistencia a nelfinavir (NFV. Es importante senalar que solo tres muestras de VIH-1 presentaron mutaciones de resistencia, las demas mostraron mutaciones compensatorias. Conclusiones: Se demuestra la existencia de mutaciones de resistencia a ARV a nivel de tr y prt de VIH-1 en sujetos peruanos que reciben terapia TARGA. Se requieren de mayores estudios para establecer un perfil de resistencia a ARV en la poblacion peruana.

  19. Russian autonomous labor colony in the People’s Republic of Tuva as a unique case of Russian regionalism

    Directory of Open Access Journals (Sweden)

    Vladimir G. Dazishen

    2016-09-01

    Full Text Available The article examines the experience of Russian regionalism in mid-19th – early 20th century Tuva, which took shape of setting up a colony of Russian subjects and became one of the most powerful factors behind the declaration of the People’s Republic of Tuva. Russian Autonomous Labor Colony (RALC was established in early 1920s and lasted for 10 years as a unique political entity in the history of Russia. RALC was fully controlled by official representatives of the Soviet state. Its stable population of over 10000 was mainly involved in cattle breeding, agriculture, crafts and even trade. RALC had its own legislation which even provided for certain elements of statehood. It was allowed to create its own flag and emblem, control its budget, and had its own military unit. The land under use by the colonists was on official lease from the government of the People’s Republic of Tuva (PRT. Ethnic Russians with Soviet citizenship complied with the legislation of the RSFSR. RALC had its own court, with convicted criminals serving their sentence in the PRT. Both RALC and PRT passed through several stages of increasingly radical left-wing reforms, which gave Moscow a firm grip over the local political establishment. In the second half of the decade the sociopolitical structure that included the RALC started to crumble away. On May 24, 1932, the autonomy was abolished by the new USSR-PRT agreement that oversaw the transformation of the colony’s remnants into Committees of Soviet Citizens. The article introduces a number of unpublished or little-known documents from the state archives of Krasnoyarsk, Novosibirsk, Irkutsk and other cities of the Russian Federation.

  20. Early Cognitive Outcomes Following Proton Radiation in Pediatric Patients With Brain and Central Nervous System Tumors

    Energy Technology Data Exchange (ETDEWEB)

    Pulsifer, Margaret B., E-mail: mpulsifer@mgh.harvard.edu [Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts (United States); Sethi, Roshan V. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Kuhlthau, Karen A. [Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts (United States); MacDonald, Shannon M.; Tarbell, Nancy J.; Yock, Torunn I. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2015-10-01

    Purpose: To report, from a longitudinal study, cognitive outcome in pediatric patients treated with proton radiation therapy (PRT) for central nervous system (CNS) tumors. Methods and Materials: Sixty patients receiving PRT for medulloblastoma (38.3%), gliomas (18.3%), craniopharyngioma (15.0%), ependymoma (11.7%), and other CNS tumors (16.7%) were administered age-appropriate measures of cognitive abilities at or near PRT initiation (baseline) and afterward (follow-up). Patients were aged ≥6 years at baseline to ensure consistency in neurocognitive measures. Results: Mean age was 12.3 years at baseline; mean follow-up interval was 2.5 years. Treatment included prior surgical resection (76.7%) and chemotherapy (61.7%). Proton radiation therapy included craniospinal irradiation (46.7%) and partial brain radiation (53.3%). At baseline, mean Wechsler Full Scale IQ was 104.6; means of all 4 Index scores were also in the average range. At follow-up, no significant change was observed in mean Wechsler Full Scale IQ, Verbal Comprehension, Perceptual Reasoning/Organization, or Working Memory. However, Processing Speed scores declined significantly (mean 5.2 points), with a significantly greater decline for subjects aged <12 years at baseline and those with the highest baseline scores. Cognitive outcome was not significantly related to gender, extent of radiation, radiation dose, tumor location, histology, socioeconomic status, chemotherapy, or history of surgical resection. Conclusions: Early cognitive outcomes after PRT for pediatric CNS tumors are encouraging, compared with published outcomes from photon radiation therapy.

  1. Ovarian steroid hormones modulate the expression of progesterone receptors and histone acetylation patterns in uterine leiomyoma cells.

    Science.gov (United States)

    Sant'Anna, Gabriela Dos Santos; Brum, Ilma Simoni; Branchini, Gisele; Pizzolato, Lolita Schneider; Capp, Edison; Corleta, Helena von Eye

    2017-08-01

    Uterine leiomyomas are the most common benign smooth muscle cell tumors in women. Estrogen (E2), progesterone (P4) and environmental factors play important roles in the development of these tumors. New treatments, such as mifepristone, have been proposed. We evaluated the gene expression of total (PRT) and B (PRB) progesterone receptors, and the histone acetyltransferase (HAT) and deacetylase (HDAC) activity after treatment with E2, P4 and mifepristone (RU486) in primary cell cultures from uterine leiomyoma and normal myometrium. Compared to myometrium, uterine leiomyoma cells showed an increase in PRT mRNA expression when treated with E2, and increase in PRB mRNA expression when treated with E2 and P4. Treatment with mifepristone had no significant impact on mRNA expression in these cells. The HDAC activity was higher in uterine leiomyoma compared to myometrial cells after treatment with E2 and E2 + P4 + mifepristone. HAT activity was barely detectable. Our results suggest that ovarian steroid hormones modulate PR, and mifepristone was unable to decrease PRT and PRB mRNA. The higher activity of HDAC leiomyoma cells could be involved in transcriptional repression of genes implicated in normal myometrium cell function, contributing to the maintenance and growth of uterine leiomyoma.

  2. The design evaluation of inductive power-transformer for personal rapid transit by measuring impedance

    International Nuclear Information System (INIS)

    Han, Kyung-Hee; Lee, Byung-Song; Baek, Soo-Hyun

    2008-01-01

    The contact-less inductive power transformer (IPT) uses the principle of electromagnetic induction. The concept of the IPT for vehicles such as the personal rapid transit (PRT) system is proposed and some suggestions for power collector design of IPT to improve power transfer performance are presented in this paper. The aim of this paper is to recommend the concept of IPT for vehicles such as the PRT system and also to present some propositions for the power collector design of the IPT, which is to improve the power transfer performance. Generally, there are diverse methods to evaluate transfer performance of the traditional transformers. Although the principle of IPT is similar to that of the general transformer, it is impossible to apply the methods directly because of large air gap. The system must be compensated by resonant circuit due to the large air gap. Consequently, it is difficult to apply numerical formulas to the magnetic design of IPT systems. This paper investigates the magnetic design of a PRT system using three-dimensional magnetic modeling and measurements of the pick-up coupling coefficient and its impedances. In addition, how the use of Litz wire and leakage inductance is related will be observed through experiment and simulation

  3. Development of an x-ray beam line at the NSLS for studies in materials science using x-ray absorption spectroscopy: Annual progress report

    International Nuclear Information System (INIS)

    Sayers, D.E.

    1986-01-01

    Although only in operation since May, 1985, the X-11 participation research team (PRT) at the NSLS has already demonstrated that it is one of the leading centers of x-ray absorption spectroscopy (XAS). During this time, results have been obtained and programs initiated in a number of areas, for example: interfaces, including deposited metal-metal and metal-semiconductor systems, multilayers and ion implanted layers; electrochemical systems, including Pt electrode fuel cells, Ni oxide battery electrodes, conducting polymers, passivation and corrosion; catalysts, including highly-dispersed supported metal catalysts and zeolite systems; quasi-crystals, heavy fermion systems, uranium and neptunium compounds, rare gas clusters, disordered metals and semiconductors, ferroelectric transition; and, biological systems and related models, including synthetic porphyrins and a number of metalloproteins. In concert with these scientific results have been a number of developments involving the technique itself. These include implementation of unique optical systems on both the A and B lines for optical performance over their designed energy ranges, advances in experimental capability, particular in glancing angle studies, optimization of ion chambers for surface studies, the improvement of electron yield detectors, and improved software for data acquisition and analysis. This report emphasizes some of the research highlights and significant developments of our PRT which occurred during the past year. A detailed bibliography of papers and talks resulting from work done at our beamline and the progress reports for our PRT which were in the 1985 NSLS Annual Report are appended

  4. Tooth for a tooth: Tissue engineering made easy at dental chairside

    Directory of Open Access Journals (Sweden)

    Vandana Kharidhi Laxman

    2017-01-01

    Full Text Available Background: Stem cells are unspecialized, multipotent cells which can differentiate into different cell types. The human periodontal ligament encloses subpopulation of Periodontal Ligament Stem Cells (PDLSCs which are able to regenerate the periodontium by differentiating into various cells of PDL. Literature have shown the promising results of periodontal regeneration by exvivo cultured transplantation of PDLSCs into the osseous defects. Methods: Based on current literature on use of ex vivo culture and associated problems, a novel technique is being presented , Stem cell application in periodontal regeneration (SAI-PRT which uses autologous PDLSCs along with its niche adhering to extracted tooth root for direct application using gelatin sponge as scaffold in regeneration of intrabony periodontal defect bypassing ex-vivo culture. Results: The cases initiated under SAI-PRT protocol, and have shown excellent clinical and radiographic improvement in intrabony defect using direct transplant of autologous PDLSCs . Conclusions: SAI-PRT can be used for the treatment of periodontal osseous defects at chair side.

  5. Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease

    Science.gov (United States)

    Aldhous, Marian C.; Abu Bakar, Suhaili; Prescott, Natalie J.; Palla, Raquel; Soo, Kimberley; Mansfield, John C.; Mathew, Christopher G.; Satsangi, Jack; Armour, John A.L.

    2010-01-01

    The copy number variation in beta-defensin genes on human chromosome 8 has been proposed to underlie susceptibility to inflammatory disorders, but presents considerable challenges for accurate typing on the scale required for adequately powered case–control studies. In this work, we have used accurate methods of copy number typing based on the paralogue ratio test (PRT) to assess beta-defensin copy number in more than 1500 UK DNA samples including more than 1000 cases of Crohn's disease. A subset of 625 samples was typed using both PRT-based methods and standard real-time PCR methods, from which direct comparisons highlight potentially serious shortcomings of a real-time PCR assay for typing this variant. Comparing our PRT-based results with two previous studies based only on real-time PCR, we find no evidence to support the reported association of Crohn's disease with either low or high beta-defensin copy number; furthermore, it is noteworthy that there are disagreements between different studies on the observed frequency distribution of copy number states among European controls. We suggest safeguards to be adopted in assessing and reporting the accuracy of copy number measurement, with particular emphasis on integer clustering of results, to avoid reporting of spurious associations in future case–control studies. PMID:20858604

  6. EFFECTS OF A SHORT-TERM PLYOMETRIC AND RESISTANCE TRAINING PROGRAM ON FITNESS PERFORMANCE IN BOYS AGE 12 TO 15 YEARS

    Directory of Open Access Journals (Sweden)

    Avery D. Faigenbaum

    2007-12-01

    Full Text Available The purpose of this study was to compare the effects of a six week training period of combined plyometric and resistance training (PRT, n = 13 or resistance training alone (RT, n = 14 on fitness performance in boys (12-15 yr. The RT group performed static stretching exercises followed by resistance training whereas the PRT group performed plyometric exercises followed by the same resistance training program. The training duration per session for both groups was 90 min. At baseline and after training all participants were tested on the vertical jump, long jump, medicine ball toss, 9.1 m sprint, pro agility shuttle run and flexibility. The PRT group made significantly (p < 0.05 greater improvements than RT in long jump (10.8 cm vs. 2.2 cm, medicine ball toss (39.1 cm vs. 17.7 cm and pro agility shuttle run time (-0.23 sec vs. -0.02 sec following training. These findings suggest that the addition of plyometric training to a resistance training program may be more beneficial than resistance training and static stretching for enhancing selected measures of upper and lower body power in boys

  7. Multilocus analysis using putative fungal effectors to describe a population of Fusarium oxysporum from sugar beet.

    Science.gov (United States)

    Covey, Paul A; Kuwitzky, Brett; Hanson, Mia; Webb, Kimberly M

    2014-08-01

    Sugar beet (Beta vulgaris) Fusarium yellows is caused by Fusarium oxysporum f. sp. betae and can lead to significant reductions in root yield, sucrose percentage, juice purity, and storability. F. oxysporum f. sp. betae can be highly variable and many F. oxysporum strains isolated from symptomatic sugar beet are nonpathogenic. Identifying pathogenicity factors and their diversity in the F. oxysporum f. sp. betae population could further understanding of how this pathogen causes disease and potentially provide molecular markers to rapidly identify pathogenic isolates. This study used several previously described fungal effector genes (Fmk1, Fow1, Pda1, PelA, PelD, Pep1, Prt1, Rho1, Sge1, Six1, Six6, Snf1, and Ste12) as genetic markers, in a population of 26 pathogenic and nonpathogenic isolates of F. oxysporum originally isolated from symptomatic sugar beet. Of the genes investigated, six were present in all F. oxysporum isolates from sugar beet (Fmk1, Fow1, PelA, Rho1, Snf1, and Ste12), and seven were found to be dispersed within the population (Pda1, PelD, Pep1, Prt1, Sge1, Six1, and Six6). Of these, Fmk1, Fow1, PelA, Rho1, Sge1, Snf1, and Ste12 were significant in relating clade designations and PelD, and Prt1 were significant for correlating with pathogenicity in F. oxysporum f. sp. betae.

  8. Speed of recovery from disorientation may predict the treatment outcome of electroconvulsive therapy (ECT) in elderly patients with major depression.

    Science.gov (United States)

    Magne Bjølseth, Tor; Engedal, Knut; Šaltytė Benth, Jūratė; Bergsholm, Per; Strømnes Dybedal, Gro; Lødøen Gaarden, Torfinn; Tanum, Lars

    2016-01-15

    No study has previously investigated whether the speed of recovery from disorientation in the post-ictal period may predict the short-term treatment outcome of electroconvulsive therapy (ECT). This longitudinal cohort study included 57 elderly patients with unipolar or bipolar major depression, aged 60-85 years, treated with formula-based ECT. Treatment outcome was assessed weekly during the ECT course using the 17-item Hamilton Rating Scale for Depression (HRSD17). The post-ictal reorientation time (PRT) was assessed at the first and third treatments. Longer PRTs at the first and third treatments predicted a more rapid decline and a lower end-point in continuous HRSD17 scores (p=0.002 and 0.019, respectively). None of the patients who recovered from disorientation in less than 5 min met the remission criterion, defined as an HRSD17 score of 7 or less. A greater increment in stimulus dosage from the first to the third ECT session rendered a smaller relative decline in PRT (p<0.001). The limited number of subjects may reduce the generalizability of the findings. The speed of recovery from disorientation at the first and third sessions seems to be a predictor of the treatment outcome of formula-based ECT, at least in elderly patients with major depression. It remains to be clarified how the PRT may be utilized to guide stimulus dosing. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  9. Neutron spectrometer for DD/DT burning ratio measurement in fusion experimental reactor

    International Nuclear Information System (INIS)

    Asai, Keisuke; Naoi, Norihiro; Iguchi, Tetsuo; Watanabe, Kenichi; Kawarabayashi, Jun; Nishitani, Takeo

    2006-01-01

    The most feasible fuels for a fusion reactor are D (Deuterium) and T (Tritium). DD and/or DT fusion reaction or nuclear burning reaction provides two kinds of neutrons, DD neutron and DT neutron, respectively. DD/DT burning ratio, which can be estimated by DD/DT neutron ratio in the burning plasma, is essential for burn control, alpha particle emission rate monitoring and tritium fuel cycle estimation. Here we propose a new neutron spectrometer for the absolute DD/DT burning ratio measurement. The system consists of a Proton Recoil Telescope (PRT) and a Time-of-Flight (TOF) technique. We have conducted preliminary experiments with a prototype detector and a DT neutron beam (φ20 mm) at the Fusion Neutronics Source, Japan Atomic Energy Agency (JAEA), to assess its basic performance. The detection efficiency obtained by the experiment is consistent with the calculation results in PRT, and sufficient energy resolution for the DD/DT neutron discrimination has been achieved in PRT and TOF. The validity of the Monte Carlo calculation has also been confirmed by comparing the experimental results with the calculation results. The design consideration of this system for use in ITER (International Thermonuclear Experimental Reactor) has shown that this system is capable of monitoring the line-integrated DD/DT burning ratio for the plasma core line of sight with the required measurement accuracy of 20% in the upper 4 decades of the ITER operation (fusion power: 100 kW-700 MW). (author)

  10. Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease.

    Science.gov (United States)

    Aldhous, Marian C; Abu Bakar, Suhaili; Prescott, Natalie J; Palla, Raquel; Soo, Kimberley; Mansfield, John C; Mathew, Christopher G; Satsangi, Jack; Armour, John A L

    2010-12-15

    The copy number variation in beta-defensin genes on human chromosome 8 has been proposed to underlie susceptibility to inflammatory disorders, but presents considerable challenges for accurate typing on the scale required for adequately powered case-control studies. In this work, we have used accurate methods of copy number typing based on the paralogue ratio test (PRT) to assess beta-defensin copy number in more than 1500 UK DNA samples including more than 1000 cases of Crohn's disease. A subset of 625 samples was typed using both PRT-based methods and standard real-time PCR methods, from which direct comparisons highlight potentially serious shortcomings of a real-time PCR assay for typing this variant. Comparing our PRT-based results with two previous studies based only on real-time PCR, we find no evidence to support the reported association of Crohn's disease with either low or high beta-defensin copy number; furthermore, it is noteworthy that there are disagreements between different studies on the observed frequency distribution of copy number states among European controls. We suggest safeguards to be adopted in assessing and reporting the accuracy of copy number measurement, with particular emphasis on integer clustering of results, to avoid reporting of spurious associations in future case-control studies.

  11. Fundamental study of photoradiation therapy for cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kashimura, Hiromasa; Kawakita, Isao; Nakahara, Akira; Sai, Shoki; Mitamura, Keiji; Fukutomi, Hisayuki; Sakita, Takao

    1984-12-01

    In an attempt to obtain basic data for endoscopical photoactivation therapy for cancer, photoactivation effect of various porphyrins have been studied using a human hepatoceller carcinoma cell line (PLC/PRF/5) and its transplanted tumors. Porphyrins tested were hematoporphyrin derivative (HpD), protoporphyrin disodium (PPNa), hematoporphyrin (Hp), coproporphyrin, and cobalt-protoporphyrin (COPP). To investigate cytocidal effects by laser irradiation with these drugs, the /sup 51/Cr release assay was used. The results indicate that laser irradiation only has no cytocidal effect, while PPNa has more intense cytocidal effect than that of HpD. To investigate anti-tumor effect by PRT further, 2mg of HpD, 2mg of PPNa or 0.9% NaCl were injected into human hepatocellar cartinomas transplanted to the flanks of BALB/c nu nu mice 48 hours before laser irradiation (514.5nm, 0.1 W, 30 min). The results were analized with respect to effects on tumor regression curve and their histology. The results suggest that laser irradiation alone has no antitumor effect, while PRT with PPNa has stronger anti-tumor effect than PRT with HpD. Therefore, PPNa may be used as a new photosensitizer for photoradiation therapy for cancer. (author).

  12. Further evaluation in field tests of the activity of three anthelmintics (fenbendazole, oxibendazole, and pyrantel pamoate) against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010).

    Science.gov (United States)

    Lyons, Eugene T; Tolliver, Sharon C; Kuzmina, Tetiana A; Collins, Sandra S

    2011-10-01

    The activity of three anthelmintics (fenbendazole-FBZ; oxibendazole-OBZ; and pyrantel pamoate-PRT) was ascertained against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010) in field tests. A total of 316 foals were treated, and 168 (53.2%) were passing ascarid eggs on the day of treatment. Evaluation of drug efficacy was determined qualitatively by comparing the number of foals passing ascarid eggs in their feces before and after treatment. The main purpose was to obtain data on current activity of these compounds against ascarids. Additionally, the objective was to compare these findings with those from earlier data on the efficacy of these three compounds on nematodes in foals in this geographical area. Efficacies (average) for the foals ranged for FBZ (10 mg/kg) from 50% to 100% (80%), for OBZ (10 mg/kg) from 75% to 100% (97%), and for PRT at 1× (6.6 mg base/kg) from 0% to 71% (2%) and at 2× (13.2 mg base/kg) 0% to 0% (0%). Although the efficacy varied among the drugs, combined data for all farms indicated a significant reduction of ascarid infections for FBZ (p < 0.0001) and OBZ (p < 0.0001) but not for PRT (p = 0.0953).

  13. Dosimetric advantages of proton therapy over conventional radiotherapy with photons in young patients and adults with low-grade glioma

    Energy Technology Data Exchange (ETDEWEB)

    Harrabi, S.B.; Herfarth, K. [Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg (Germany); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg (Germany); University Hospital Heidelberg, Dept. of Radiation Oncology, Heidelberg (Germany); Bougatf, N. [Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg (Germany); University Hospital Heidelberg, Dept. of Radiation Oncology, Heidelberg (Germany); German Cancer Research Center (DKFZ), Department of Medical Physics in Radiation Oncology, Heidelberg (Germany); Mohr, A. [Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg (Germany); University Hospital Heidelberg, Dept. of Radiation Oncology, Heidelberg (Germany); Haberer, T. [Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg (Germany); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg (Germany); Combs, S.E. [Helmholtz Zentrum Muenchen, Department of Radiation Sciences (DRS), Institute of Innovative Radiotherapy (iRT), Oberschleissheim (Germany); Deutsches Konsortium fuer Translationale Krebsforschung (dktk), Partner Site Munich, Munich (Germany); Debus, J.; Adeberg, S. [Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg (Germany); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg (Germany); University Hospital Heidelberg, Dept. of Radiation Oncology, Heidelberg (Germany); German Cancer Research Center (DKFZ), Clinical Cooperation Unit Radiation Oncology, Heidelberg (Germany)

    2016-11-15

    Low-grade glioma (LGG) is a very common brain tumor in pediatric patients typically associated with a very good prognosis. This prognosis makes it imperative that the risk of long-term treatment-related side effects be kept at an absolute minimum. Proton therapy (PRT) provides a radiation technique that has the potential to further reduce the genesis of radiogenic impairment. We retrospectively assessed 74 patients with LGG who underwent PRT. Conventional three-dimensional photon and PRT plans were generated after contouring structures of neurogenesis, crucial neuronal structures, and areas susceptible to secondary malignancies. Target volume coverage was evaluated using the homogeneity index (HI) and inhomogeneity coefficient (IC). Results were compared using the Wilcoxon-signed rank test, with p < 0.05 being statistically significant. Target volume coverage was comparable for the photon and proton plans. Overall, we could show an essential reduction in maximal, mean, and integral doses in critical neurologic structures, areas of neurogenesis, and structures of neurocognitive function. The study indicated specifically how contralaterally located structures could be spared with PRT. PRT is a highly conformal radiation technique offering superior dosimetric advantages over conventional radiotherapy by allowing significant dose reduction for organs at risk (OAR) that are essential for neurologic function, neurocognition, and quality of life, thus demonstrating the potential of this technique for minimizing long-term sequelae. (orig.) [German] Niedriggradige Gliome (LGG) zaehlen zu den haeufigsten Hirntumoren im Kindesalter und sind ueblicherweise mit einer sehr guten Prognose vergesellschaftet. Es gilt daher, das Risiko fuer therapieassoziierte Spaetfolgen so gering wie moeglich zu halten. Mit der Protonenbestrahlung steht eine Bestrahlungsmodalitaet zur Verfuegung, mit der das Auftreten radiogener Spaetfolgen im Vergleich zu konventionellen Bestrahlungstechniken

  14. The effects of a protein enriched diet with lean red meat combined with a multi-modal exercise program on muscle and cognitive health and function in older adults: study protocol for a randomised controlled trial.

    Science.gov (United States)

    Daly, Robin M; Gianoudis, Jenny; Prosser, Melissa; Kidgell, Dawson; Ellis, Kathryn A; O'Connell, Stella; Nowson, Caryl A

    2015-08-08

    Age-related muscle wasting has been strongly implicated with falls and fractures in the elderly, but it has also been associated with cognitive decline and dementia. Progressive resistance training (PRT) and adequate dietary protein are recognised as important contributors to the maintenance of muscle health and function in older adults. However, both factors also have the potential to improve brain function and prevent cognitive decline via several pathways, including the regulation of various growth and neurotrophic factors [insulin-like growth factor-1 (IGF-1)]; brain-derived growth factor (BDNF)] and/or the modulation of systemic inflammation. The primary aim of this study is to investigate whether a modest increase in dietary protein achieved through the consumption of lean red meat three days per week, when combined with PRT, can enhance muscle mass, size and strength and cognitive function in community-dwelling older people. The study design is a 48-week randomised controlled trial consisting of a 24-week intervention with a 24-week follow-up. Men and women (n=152) aged 65 years and over residing in the community will be randomly allocated to: 1) PRT and provided with 220 g (raw weight) of lean red meat to be cooked and divided into two 80 g servings on each of the three days that they complete their exercise session, or 2) control PRT in which participants will be provided with and advised to consume ≥1 serving (~1/2 cup) of rice and/or pasta or 1 medium potato on each of the three training days. The primary outcome measures will be muscle mass, size and strength and cognitive function. Secondary outcomes will include changes in: muscle function, neural health (corticospinal excitability and inhibition and voluntary activation), serum IGF-1 and BDNF, adipokines and inflammatory markers, fat mass and inter-/intra-muscular fat, blood pressure, lipids and health-related quality of life. All outcome measures will be assessed at baseline and 24 weeks, with the

  15. Biochemical composition of seston in two upwelling sites within the Humboldt Current System (21°S to 23°S): Summer conditions

    Science.gov (United States)

    Isla, Enrique; Homs, Patricia; Sañé, Elisabet; Escribano, Rubén; Claramunt, Gabriel; Teixidó, Nuria

    2010-07-01

    The biochemical composition of seston within the Humboldt Current System (HCS) in two bays off northern Chile (21°S-23°S) was assessed to estimate its chemical quality as potential food supply for benthic communities, large zooplankton and fish larvae. As part of the CENSOR project, in the summer of 2006 physical and biochemical variables were analyzed in Chipana and Mejillones Bays during one week at four depths determined by the occurrence of the upper boundary of the oxygen minimum zone and fluorescence peaks. The depth of the oxy- and pycnoclines controlled the distribution of biochemical variables in both bays. There were significant differences in the concentration of protein (PRT), lipid (LPD) and carbohydrates (CHO) among depths in both bays. The differences were also found in the PRT and LPD contribution to the biopolymeric carbon (BPC) among bays and among depths in the case of CHO. However, the concentration of suspended particulate matter and biogenic silica (bSi) were similar in both bays. PRT, LPD and CHO showed the highest concentrations in the upper meters of the water column and small peaks close to the seabed related to sediment resuspension and/or lateral transport. In Chipana Bay, the high nutritive quality of seston occurring near the seabed suggests a rapid sinking of diatom aggregates and a reduced respiration of the particulate organic matter. PRT, LPD and CHO varied between 0.05 and 0.47 mg l - 1 , 0.06 and 0.39 mg l - 1 and 0.07 and 0.51 mg l - 1 , respectively. LPD were the most important contributors to the BPC in both bays. The seston in these bays presented a high PRT and LPD content in comparison to a number of settings of different latitudes and oceanographic characteristics. The high quantity and biochemical quality of the particulate matter in both bays may reflect the high productivity of this zone and partially explain their condition as spawning areas within the HCS.

  16. Effect of Irradiation on Tumor Microenvironment and Bone Marrow Cell Migration in a Preclinical Tumor Model

    Energy Technology Data Exchange (ETDEWEB)

    Kane, Jonathan L. [Department of Biological Sciences, Oakland University, Rochester, Michigan (United States); Department of Radiation Oncology, William Beaumont Health System, Royal Oak, Michigan (United States); Krueger, Sarah A.; Hanna, Alaa [Department of Radiation Oncology, William Beaumont Health System, Royal Oak, Michigan (United States); Raffel, Thomas R. [Department of Biological Sciences, Oakland University, Rochester, Michigan (United States); Wilson, George D. [Department of Radiation Oncology, William Beaumont Health System, Royal Oak, Michigan (United States); Madlambayan, Gerard J. [Department of Biological Sciences, Oakland University, Rochester, Michigan (United States); Marples, Brian, E-mail: Brian.Marples@beaumont.edu [Department of Radiation Oncology, William Beaumont Health System, Royal Oak, Michigan (United States)

    2016-09-01

    Purpose: To characterize the tumor microenvironment after standard radiation therapy (SRT) and pulsed radiation therapy (PRT) in Lewis lung carcinoma (LLC) allografts. Methods and Materials: Subcutaneous LLC tumors were established in C57BL/6 mice. Standard RT or PRT was given at 2 Gy/d for a total dose of 20 Gy using a 5 days on, 2 days off schedule to mimic clinical delivery. Radiation-induced tumor microenvironment changes were examined after treatment using flow cytometry and antibody-specific histopathology. Normal tissue effects were measured using noninvasive {sup 18}F-fluorodeoxyglucose positron emission tomography/computed tomography after naïve animals were given whole-lung irradiation to 40 Gy in 4 weeks using the same 2-Gy/d regimens. Results: Over the 2 weeks of therapy, PRT was more effective than SRT at reducing tumor growth rate (0.31 ± 0.02 mm{sup 3}/d and 0.55 ± 0.04 mm{sup 3}/d, respectively; P<.007). Histopathology showed a significant comparative reduction in the levels of Ki-67 (14.5% ± 3%), hypoxia (10% ± 3.5%), vascular endothelial growth factor (2.3% ± 1%), and stromal-derived factor-1α (2.5% ± 1.4%), as well as a concomitant decrease in CD45{sup +} bone marrow–derived cell (BMDC) migration (7.8% ± 2.2%) after PRT. The addition of AMD3100 also decreased CD45{sup +} BMDC migration in treated tumors (0.6% ± 0.1%). Higher vessel density was observed in treated tumors. No differences were observed in normal lung tissue after PRT or SRT. Conclusions: Pulsed RT–treated tumors exhibited slower growth and reduced hypoxia. Pulsed RT eliminated initiation of supportive mechanisms utilized by tumors in low oxygen microenvironments, including angiogenesis and recruitment of BMDCs.

  17. Protein-enriched diet, with the use of lean red meat, combined with progressive resistance training enhances lean tissue mass and muscle strength and reduces circulating IL-6 concentrations in elderly women: a cluster randomized controlled trial.

    Science.gov (United States)

    Daly, Robin M; O'Connell, Stella L; Mundell, Niamh L; Grimes, Carley A; Dunstan, David W; Nowson, Caryl A

    2014-04-01

    Physical inactivity, inadequate dietary protein, and low-grade systemic inflammation contribute to age-related muscle loss, impaired function, and disability. We assessed the effects of progressive resistance training (PRT) combined with a protein-enriched diet facilitated through lean red meat on lean tissue mass (LTM), muscle size, strength and function, circulating inflammatory markers, blood pressure, and lipids in elderly women. In a 4-mo cluster randomized controlled trial, 100 women aged 60-90 y who were residing in 15 retirement villages were allocated to receive PRT with lean red meat (∼160 g cooked) to be consumed 6 d/wk [resistance training plus lean red meat (RT+Meat) group; n = 53] or control PRT [1 serving pasta or rice/d; control resistance training (CRT) group; n = 47)]. All women undertook PRT 2 times/wk and received 1000 IU vitamin D3/d. The mean (± SD) protein intake was greater in the RT+Meat group than in the CRT group throughout the study (1.3 ± 0.3 compared with 1.1 ± 0.3 g · kg⁻¹ · d⁻¹, respectively; P < 0.05). The RT+Meat group experienced greater gains in total body LTM (0.45 kg; 95% CI: 0.07, 0.84 kg), leg LTM (0.22 kg; 95% CI: 0.02, 0.42 kg), and muscle strength (18%; 95% CI: 0.03, 0.34) than did the CRT group (all P < 0.05). The RT+Meat group also experienced a 10% greater increase in serum insulin-like growth factor I (P < 0.05) and a 16% greater reduction in the proinflammatory marker interleukin-6 (IL-6) (P < 0.05) after 4 mo. There were no between-group differences for the change in blood lipids or blood pressure. A protein-enriched diet equivalent to ∼1.3 g · kg⁻¹ · d⁻¹ achieved through lean red meat is safe and effective for enhancing the effects of PRT on LTM and muscle strength and reducing circulating IL-6 concentrations in elderly women. This trial was registered at the Australian Clinical Trials Registry as ACTRN12609000223235.

  18. Combined effects of compact cevelopment, transportation investments, and road user pricing on vehicle miles traveled in urbanized areas

    Science.gov (United States)

    Ewing, Reid; Hamidi, Shima; Gallivan, Frank; Nelson, Arthur C.; Grace, James B.

    2014-01-01

    Vehicle miles traveled (VMT) is the primary determinant of traffic congestion, vehicle crashes, greenhouse gas emissions, and other effects of transportation. Two previous studies have sought to explain VMT levels in urbanized areas. This study updates and expands on previous work with more recent data, additional metrics, and structural equation modeling (SEM) to explain VMT levels in 315 urbanized areas. According to SEM, population, income, and gasoline prices are primary exogenous drivers of VMT. Development density is a primary endogenous driver. Urbanized areas with more freeway capacity are significantly less dense and have significantly higher VMT per capita. Areas with more transit service coverage and service frequency have higher development densities and per capita transit use, which leads to lower VMT per capita. The indirect effect of transit on VMT through land use, the so-called land use multiplier, is more than three times greater than the direct effect through transit ridership.

  19. A review of the program of the Office of the Commission for the Management of Road Traffic

    Energy Technology Data Exchange (ETDEWEB)

    Saraswadi, K.

    1995-12-31

    This report describes the development of a Mass Rapid Transit Systems Master Plan by the Office for the Commission of Road Traffic (OCMRT) for Bangkok as detailed in the full Master Plan document. The Master Plan document addresses the following topic areas: evolution of the Master Plan Concept; socio-economic and development benefits; transport model development and applications; ridership findings; environmental considerations; capital and operating costs; economic and financial analysis findings; priority projects and construction program phasing; and implementation of the Master Plan - institutional issues. Each of these topics is discussed in further detail in its own chapter in the document. For purposes of this workshop and subsequent proceedings, the last section is highlighed in this presentation.

  20. Life-cycle assessment of high-speed rail: the case of California

    International Nuclear Information System (INIS)

    Chester, Mikhail; Horvath, Arpad

    2010-01-01

    The state of California is expected to have significant population growth in the next half-century resulting in additional passenger transportation demand. Planning for a high-speed rail system connecting San Diego, Los Angeles, San Francisco, and Sacramento as well as many population centers between is now underway. The considerable investment in California high-speed rail has been debated for some time and now includes the energy and environmental tradeoffs. The per-trip energy consumption, greenhouse gas emissions, and other emissions are often compared against the alternatives (automobiles, heavy rail, and aircraft), but typically only considering vehicle operation. An environmental life-cycle assessment of the four modes was created to compare both direct effects of vehicle operation and indirect effects from vehicle, infrastructure, and fuel components. Energy consumption, greenhouse gas emissions, and SO 2 , CO, NO X , VOC, and PM 10 emissions were evaluated. The energy and emission intensities of each mode were normalized per passenger kilometer traveled by using high and low occupancies to illustrate the range in modal environmental performance at potential ridership levels. While high-speed rail has the potential to be the lowest energy consumer and greenhouse gas emitter, appropriate planning and continued investment would be needed to ensure sustained high occupancy. The time to environmental payback is discussed highlighting the ridership conditions where high-speed rail will or will not produce fewer environmental burdens than existing modes. Furthermore, environmental tradeoffs may occur. High-speed rail may lower energy consumption and greenhouse gas emissions per trip but can create more SO 2 emissions (given the current electricity mix) leading to environmental acidification and human health issues. The significance of life-cycle inventorying is discussed as well as the potential of increasing occupancy on mass transit modes.

  1. Privatisation of fixed-rail transit systems : a case study of Malaysia's STAR and PUTRA

    Energy Technology Data Exchange (ETDEWEB)

    Abdul-Aziz, A.R. [St. Malaysia Univ., (Malaysia). School of Housing, Building and Planning

    2006-06-15

    Malaysia was the first developing country to embrace the idea of privatizing its public utilities in an effort to reduce public expenditure and improve services. Many public utilities were sold in the early 1980s under Malaysia's privatization program. Some, however, have returned to government hands. Among them are the two light-rail transit (LRT) systems in the capital city of Kuala Lumpur. The main objective of privatization had been to expand transportation capabilities to keep pace with economic development. The private sector was allowed to construct various rail-based mass transportation systems to alleviate vehicular traffic congestion in the city. The STAR and PUTRA light-rail transit systems were built in the 1990s by 2 concession companies at a total cost of US$2.27 billion with the bulk of the expenditure going into infrastructure and rolling stock. Generous financial incentives were offered by the Malaysian government. However, the 2 LRTs suffered below-expectation ridership right from the beginning. Even a reduction in rates to promote greater public use, failed to meet projected ridership figures. The concession companies began defaulting on their loan servicing obligations within months of becoming operational. In 2002, the government took over the operation of the 2 LRT systems. The pre- and post-privatization events of both facilities were chronicled in this paper. It examined how the entire process was administered and tried to rationalize why private ownership of the 2 LRT systems was short-lived. Based on publicly available material, this paper argued that neither the quality of government negotiators nor the length of time devoted to negotiating could be attributed to the bailout. There was no indication that political favouritism and corruption were at play. Rather, the 2 projects proved to be financially unviable, despite the large financial incentives provided to the two concession companies. 83 refs., 5 tabs.

  2. Unhealthful Food-and-Beverage Advertising in Subway Stations: Targeted Marketing, Vulnerable Groups, Dietary Intake, and Poor Health.

    Science.gov (United States)

    Lucan, Sean C; Maroko, Andrew R; Sanon, Omar C; Schechter, Clyde B

    2017-04-01

    Unhealthful food-and-beverage advertising often targets vulnerable groups. The extent of such advertising in subway stations has not been reported and it is not clear how ad placement may relate to subway ridership or community demographics, or what the implications might be for diets and diet-related health in surrounding communities. Riding all subway lines (n = 7) in the Bronx, NY, USA, investigators systematically assessed all print ads (n = 1586) in all stations (n = 68) in 2012. Data about subway ridership came from the Metropolitan Transportation Authority. Demographic data on surrounding residential areas came from the U.S. Census Bureau. Data on dietary intake and diet-related conditions came from a city health-department survey. There were no ads promoting "more-healthful" food-or-beverage items (i.e., fruits, vegetables, whole grains, nuts, water or milk). There were many ads for "less-healthful" items (e.g., candies, chips, sugary cereals, frozen pizzas, "energy" drinks, coffee confections, hard alcohol, and beer). Ad placement did not relate to the number of riders entering at stations. Instead, exposure to food-or-beverage ads generally, and to "less-healthful" ads particularly (specifically ads in Spanish, directed at youth, and/or featuring minorities), was directly correlated with poverty, lower high-school graduation rates, higher percentages of Hispanics, and/or higher percentages of children in surrounding residential areas. Correlations were robust to sensitivity analyses. Additional analyses suggested correlations between ad exposures and sugary-drink consumption, fruit-and-vegetable intake, and diabetes, hypertension, and high-cholesterol rates. Subway-station ads for "less-healthful" items were located disproportionately in areas home to vulnerable populations facing diet and diet-related-health challenges. The fact that uneven ad placement did not relate to total rider counts suggests ads were not directed at the largest

  3. An Assessment of Public Transport Facility in Johor Bahru: a case study in Taman Ungku Tun Aminah Area, Majlis Perbandaran Johor Bahru Tengah, Malaysia

    Directory of Open Access Journals (Sweden)

    Musarrat Zaman

    2017-05-01

    Full Text Available Provision of public transport infrastructure is important to increase the ridership and at the same time decrease the use of private transport. Like the other Malaysian cities, Johor Bahru is mostly dependent on private vehicles such as motor cars and motor cycles. The ridership on public transport especially public bus is getting lower over the years. In this situation the sustainability in transportation and land use cannot be ensured. This paper aims to assess the public transport facility in Taman Ungku Tun Aminah in Johor Bahru which is very old and traditional residential area with some major extent of commercial and educational land uses. The actual scenario of public transport service and underlying problems that impeded the residents to use public bus service is observed in this paper. The possible options for the improvement of the bus service and turning it into an effective short and medium length inter town travel media are also discussed as well. Both the primary and secondary information are collected for the purpose of study. Various descriptive statistical data analysis are done in order to get the expected outcome from the collected data. According to this study only 26.7% of the respondents use public bus for their daily travel. The opinion of the respondents is taken for the underlying causes of their reluctance on using public bus service and also the effective measures for the enhancement of this service to the users like them. Finally some recommendations and strategic actions and policy frameworks are also suggested in this paper.

  4. Direct gravimetric measurements of the mass of the antarctic aerosol collected by high volume sampler: PM10 summer seasonal variation at Terra Nova Bay.

    Science.gov (United States)

    Truzzi, Cristina; Lambertucci, Luca; Illuminati, Silvia; Annibaldi, Anna; Scarponi, Giuseppe

    2005-01-01

    An on-site procedure was set up for direct gravimetric measurement of the mass of aerosol collected using high volume impactors (aerodynamic size cut point of 10 microm, PM10); this knowledge has hitherto been unavailable. Using a computerized microbalance in a clean chemistry laboratory, under controlled temperature (+/-0.5 degrees C) and relative humidity (+/-1%), continuous, long time filter mass measurements (hours) were carried out before and after exposure, after a 48 h minimun equilibration at the laboratory conditions. The effect of the electrostatic charge was exhausted in 30-60 min, after which stable measurements were obtained. Measurements of filters exposed for 7-11 days (1.13 m3 min(-1)) in a coastal site near Terra Nova Bay (December 2000 - February 2001), gave results for aerosol mass in the order of 10-20 mg (SD approximately 2 mg), corresponding to atmospheric concentrations of 0.52-1.27 microg m(-3). Data show a seasonal behaviour in the PM10 content with an increase during December - early January, followed by a net decrease. The above results compare well with estimates obtained from proxy data for the Antarctic Peninsula (0.30 microg m(-3)), the Ronne Ice Shelf (1.49 microg m(-3)), and the South Pole (0.18 microg m(-3), summer 1974-1975, and 0.37 microg m(-3), average summer seasons 1975-1976 and 1977-1978), and from direct gravimetric measurements recently obtained from medium volume samplers at McMurdo station (downwind 3.39 microg m(-3), upwind 4.15 microg m(-3)) and at King George Island (2.5 microg m(-3), summer, particle diameter <20 microm). This finding opens the way to the direct measurement of the chemical composition of the Antarctic aerosol and, in turn, to a better knowledge of the snow/air relationships as required for the reconstruction of the chemical composition of past atmospheres from deep ice core data.

  5. Produção primária e algumas considerações ecológicas da região de Ubatuba (Lat. 23º30's - Long. 45º06'w, Brasil Primary production and some ecological considerations from Ubatuba region (Lat. 23º30'S - Long. 45º06'W, Brazil

    Directory of Open Access Journals (Sweden)

    Clóvis Teixeira

    1979-01-01

    Full Text Available Medidas sobre produção primária, foram determinadas em trés diferentes pontos de uma enseada (Lat. 23º30'S; Long. 45º06'W durante o inverno e verão (1975-1976 . Algumas características fotossintéticas das populações naturais foram determinadas em condições simuladas. Os valores da produção primaria, relacionados às condições ambientais e aos diferentes valores C:clorofila-a encontrados, demonstraram que a região estudada apresenta características oligotroficas . A composição do fitoplâncton, com relaçao ao seu tamanho celular, deve, entretanto, favorecer um aproveitamento máximo dos nutrientes em termos de assimilação e propiciar uma elevada taxa de multiplicação celular. Os altos valores encontrados para os diferentes demonstraram que as populações estudadas sao adaptadas às altas intensidades luminosas, desde que nenhuma barreira física seja estabelecida. Além das considerações ecologicas apresentadas, os dados obtidos permitiram sugerir uma possível viabilidade da criação de organismos filtradores como uma opção para a maricultura.Primary production and hydrographic measurements were taken at three different points at a bight (Lat. 23º30'S; Long. 45º06'W during the winter and summer (1975-76. Some photosynthetic characteristics of the natural populations were also simulated in laboratory experiments. The relation between primary production and the environmental parameters, as well as with the different values of C: chlorophyll obtained, showed that the region is oligotrophic. However the cell size composition of phytoplarikton may promove a maximum uptake of nutrients and improve the cellular reproduction. High values found for Ik showed that the population is adapted to high intensities as long as no physical barrier is established. Besides the ecological aspects presented the results allow us to suggest the viability of growing filter-feeding organisms as an option for marine culture.

  6. Research within the coordinated programme on isotopic-tracer-aided studies of chemical residues in cotton seed, oil, feed and related products

    International Nuclear Information System (INIS)

    Qureshi, M.J.

    1981-06-01

    14 C-methyl and 14 C-ring-labelled carbaryl (1-naphthyl-N-methyl carbamate) were used to study the fate and magnitude of the insecticide in the plant and cotton seed products. Under conditions of actual agricultural practice, 0.08-0.09, 0.23-0.30 and 0.05 mg/kg of 14 C-residues were found in the seed, crude oil and cake respectively. In oil, the residue was resolved into 4 compounds, 2 identified as carbaryl and 1-naphthol. Residues from the soil did not exceed 0.3 mg/kg after the first week and declined to 0.1 mg/kg after 5 weeks. Parallel experiments were conducted under field conditions using 14 C-phenyl leptophos (4-bromo-2,5-dichlorophenyl methyl phenyl phosphorothioate). Leptophos residues were determined in the cotton seed products during 1975, 1976 and 1977, with mean values for leptophos residues in the cotton seed, crude oil and cake of 0.26, 1.10 and 0.07 mg/kg, respectively. Experiments with non-labelled monocrotophos [3-(dimethoxy phosphinyloxy)-N-methyl cis-crotonamide] gave residues of 0.30, 1.56 and 0.02 mg/kg in the seed, crude oil and cake, respectively. Carbaryl residues in two local maize varieties were determined by a colorimetric method. Cooking in aqueous, oil or aqueous-oil media led to 63-83% loss of carbaryl residues, after 30 minutes. Storage of corn oil for one year had essentially no effect on the concentration of carbaryl residues under laboratory conditions (presumably similar to regular storage conditions). An overall effect of simulated commercial processing procedures (saponification, deodorization and winterization) gave a loss of 70% of the original carbaryl in the oil. Commercial cooking procedures for national popular dishes resulted in near-complete elimination of carbaryl residues (up to 98%). Frying onions and potatoes in carbaryl-spiked corn oil for 3 min. up to 210 0 C resulted in 55-60% loss of the residue

  7. Les hommes et la peste en France et dans les pays européens et méditerranéens: tomo I. La peste dans l'histoire e tomo II Les hommes face à la peste

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    Hilario Franco Júnior

    1977-09-01

    Full Text Available BIRABEN, Jean-Nöel. Les hommes et la peste en France et dans les pays européens et méditerranéens: tomo I. La peste dans l'histoire e tomo II Les hommes face à la peste. Paris: Mouton, 1975-1976. (primeiro parágrafo do texto Os dois volumes desta obra foram concebidos de maneiras diferentes, o primeiro com uma estrutura histórica, voltada para a evolução da peste através do tempo, o segundo examinando as diversas formas do homem encarar aquele flagelo. Inicialmente o autor faz uma introdução médico-epidemiológica, fornecendo certas noções importantes, e quase sempre desconhecidas do historiador e do demógrafo, para se seguir o desenvolvimento histórico da peste. Este é então examinado em três grandes momentos: a peste justiniana da Alta Idade Média, a Peste Negra do século XIV e a peste na Época Moderna, até seu desaparecimento do Ocidente na primeira metade do século XVIII. Depois de o ritmo sazonal da peste e seu reaparecimento cíclico terem sido estudados, a atenção de Biraben volta-se para as perdas humanas provocadas pela doença, bem como para o comportamento demográfico das populações em tempo de peste. O segundo volume começa com um interessante estudo das concepções antigas sobre a peste, vista dentre outras formas como resultado de castigo divino, de conjunção de planetas, de eclipses, ou da passagem de cometas. Analisa-se em seguida a luta contra a peste, que assumia duas formas: de um lado, magia, sacrifícios, exorcismos, uso de talismãs, preces, procissões, apelo a santos e outras crendices; de outro lado, com uma crescente importância, a presença cada vez mais constante das intervenções estatais, através de regulamentos sobre higiene, medidas contra o contágio, contra a difusão da peste de uma região para outras, recrutamento de pessoal especializado para tratar dos doentes, etc.

  8. Geochemistry of the late Holocene rocks from the Tolbachik volcanic field, Kamchatka: Quantitative modelling of subduction-related open magmatic systems

    Science.gov (United States)

    Portnyagin, Maxim; Duggen, Svend; Hauff, Folkmar; Mironov, Nikita; Bindeman, Ilya; Thirlwall, Matthew; Hoernle, Kaj

    2015-12-01

    We present new major and trace element, high-precision Sr-Nd-Pb (double spike), and O-isotope data for the whole range of rocks from the Holocene Tolbachik volcanic field in the Central Kamchatka Depression (CKD). The Tolbachik rocks range from high-Mg basalts to low-Mg basaltic trachyandesites. The rocks considered in this paper represent mostly Late Holocene eruptions (using tephrochronological dating), including historic ones in 1941, 1975-1976 and 2012-2013. Major compositional features of the Tolbachik volcanic rocks include the prolonged predominance of one erupted magma type, close association of middle-K primitive and high-K evolved rocks, large variations in incompatible element abundances and ratios but narrow range in isotopic composition. We quantify the conditions of the Tolbachik magma origin and evolution and revise previously proposed models. We conclude that all Tolbachik rocks are genetically related by crystal fractionation of medium-K primary magmas with only a small range in trace element and isotope composition. The primary Tolbachik magmas contain 14 wt.% of MgO and 4% wt.% of H2O and originated by partial melting ( 6%) of moderately depleted mantle peridotite with Indian-MORB-type isotopic composition at temperature of 1250 °C and pressure of 2 GPa. The melting of the mantle wedge was triggered by slab-derived hydrous melts formed at 2.8 GPa and 725 °C from a mixture of sediments and MORB- and Meiji-type altered oceanic crust. The primary magmas experienced a complex open-system evolution termed Recharge-Evacuation-Fractional Crystallization (REFC). First the original primary magmas underwent open-system crystal fractionation combined with periodic recharge of the magma chamber with more primitive magma, followed by mixing of both magma types, further fractionation and finally eruption. Evolved high-K basalts, which predominate in the Tolbachik field, and basaltic trachyandesites erupted in 2012-2013 approach steady-state REFC liquid

  9. Tissue As A Medium For Laser Light Transport-Implications For Photoradiation Therapy

    Science.gov (United States)

    Preuss, L. E.; Bolin, F. P.; Cain, B. W.

    1982-12-01

    An important medical laser application is in the emerging field of photoradiation therapy (PRT). PRT is the process in which malignant tissue is destroyed by administration of light to a specific photosensitized site. Filtered arcs, incandescents and dye lasers have been used as sources of activating light. We have carried out light experiments in tissue to study such PRT light distributions. The results of this research have shown that a number of important optical phenomena occurring within illuminated tissue must be accounted for in order to make good predictions of tumor light dosage. Among these are; tissue type, interface effects and anomalies due to composition. These effects substantially influence light levels in PRT and, thus, the therapeutic effect. The uniqueness of tissue as a medium for light transport presents special problems for optics research and instrumentation. Successful solutions necessarily will involve collaboration between the life sciences and optic specialists. Attempts at treatment of human disease using non-ionizing radiation have a history archaeologically traceable to archaic societies (in which the sun's photons were used and often worshipped).1 Western medicine in the past, has used visible light beneficially, albeit empirically, on a few ailments. However, in this century, a significant development in the understanding and in the therapeutic use of this electromagnetic radiation in the UV, visible and IR has occurred, based on scientific study. This utilization of radiation in the visible and ultraviolet can be by two distinct processes. One is through the direct action of the photons which serve as the sole treatment agent. In this case the photon interacts with the cell, or its components, in a single step, to produce a desired effect. An example is the successful use of blue light for treatment of bilirubinemia in newborns. The second process is a biological effect produced through the combination of electromagnetic radiation

  10. A novel rat genomic simple repeat DNA with RNA-homology shows triplex (H-DNA)-like structure and tissue-specific RNA expression

    International Nuclear Information System (INIS)

    Dey, Indranil; Rath, Pramod C.

    2005-01-01

    Mammalian genome contains a wide variety of repetitive DNA sequences of relatively unknown function. We report a novel 227 bp simple repeat DNA (3.3 DNA) with a d {(GA) 7 A (AG) 7 } dinucleotide mirror repeat from the rat (Rattus norvegicus) genome. 3.3 DNA showed 75-85% homology with several eukaryotic mRNAs due to (GA/CU) n dinucleotide repeats by nBlast search and a dispersed distribution in the rat genome by Southern blot hybridization with [ 32 P]3.3 DNA. The d {(GA) 7 A (AG) 7 } mirror repeat formed a triplex (H-DNA)-like structure in vitro. Two large RNAs of 9.1 and 7.5 kb were detected by [ 32 P]3.3 DNA in rat brain by Northern blot hybridization indicating expression of such simple sequence repeats at RNA level in vivo. Further, several cDNAs were isolated from a rat cDNA library by [ 32 P]3.3 DNA probe. Three such cDNAs showed tissue-specific RNA expression in rat. pRT 4.1 cDNA showed strong expression of a 2.39 kb RNA in brain and spleen, pRT 5.5 cDNA showed strong expression of a 2.8 kb RNA in brain and a 3.9 kb RNA in lungs, and pRT 11.4 cDNA showed weak expression of a 2.4 kb RNA in lungs. Thus, genomic simple sequence repeats containing d (GA/CT) n dinucleotides are transcriptionally expressed and regulated in rat tissues. Such d (GA/CT) n dinucleotide repeats may form structural elements (e.g., triplex) which may be sites for functional regulation of genomic coding sequences as well as RNAs. This may be a general function of such transcriptionally active simple sequence repeats widely dispersed in mammalian genome

  11. Effects of acute static, ballistic, and PNF stretching exercise on the muscle and tendon tissue properties.

    Science.gov (United States)

    Konrad, A; Stafilidis, S; Tilp, M

    2017-10-01

    The purpose of this study was to investigate the influence of a single static, ballistic, or proprioceptive neuromuscular facilitation (PNF) stretching exercise on the various muscle-tendon parameters of the lower leg and to detect possible differences in the effects between the methods. Volunteers (n = 122) were randomly divided into static, ballistic, and PNF stretching groups and a control group. Before and after the 4 × 30 s stretching intervention, we determined the maximum dorsiflexion range of motion (RoM) with the corresponding fascicle length and pennation angle of the gastrocnemius medialis. Passive resistive torque (PRT) and maximum voluntary contraction (MVC) were measured with a dynamometer. Observation of muscle-tendon junction (MTJ) displacement with ultrasound allowed us to determine the length changes in the tendon and muscle, respectively, and hence to calculate stiffness. Although RoM increased (static: +4.3%, ballistic: +4.5%, PNF: +3.5%), PRT (static: -11.4%, ballistic: -11.5%, PNF: -13,7%), muscle stiffness (static: -13.1%, ballistic: -20.3%, PNF: -20.2%), and muscle-tendon stiffness (static: -11.3%, ballistic: -10.5%, PNF: -13.7%) decreased significantly in all the stretching groups. Only in the PNF stretching group, the pennation angle in the stretched position (-4.2%) and plantar flexor MVC (-4.6%) decreased significantly. Multivariate analysis showed no clinically relevant difference between the stretching groups. The increase in RoM and the decrease in PRT and muscle-tendon stiffness could be explained by more compliant muscle tissue following a single static, ballistic, or PNF stretching exercise. © 2017 The Authors Scandinavian Journal of Medicine & Science In Sports Published by John Wiley & Sons Ltd.

  12. Effects of ginger (Zingiber officinale Roscoe supplementation and resistance training on some blood oxidative stress markers in obese men

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    Sirvan Atashak

    2014-06-01

    Full Text Available Excessive adiposity increases oxidative stress, and thus may play a critical role in the pathogenesis and development of obesity-associated comorbidities, in particular atherosclerosis, diabetes mellitus, and arterial hypertension. Improved body composition, through exercise training and diet, may therefore significantly contribute to a reduction in oxidative stress. Further, some foods high in antioxidants (e.g., ginger provide additional defense against oxidation. This study was conducted to assess the effects of ginger (Zingiber officinale Roscoe supplementation and progressive resistance training (PRT on some nonenzymatic blood [total antioxidant capacity (TAC and malondialdehyde (MDA] oxidative stress markers in obese men. Thirty-two obese males (body mass index ≥30, aged 18–30 years were randomized to one of the following four groups: a placebo (PL; n = 8; resistance training plus placebo (RTPL; n = 8; resistance training plus ginger supplementation (RTGI; n = 8; and ginger supplementation only (GI; n = 8. Participants in the RTGI and GI groups consumed 1 g ginger/day for 10 weeks. At the same time, PRT was undertaken by the RTPL and RTGI groups three times/week. Resting blood samples were collected at baseline and at 10 weeks, and analyzed for plasma nonenzymatic TAC and MDA concentration. After the 10-week intervention, we observed significant training × ginger supplementation × resistance training interaction for TAC (p = 0.043 and significant interactions for training × resistance training and training × ginger supplementation for MDA levels (p < 0.05. The results of this study show that 10 weeks of either ginger supplementation or PRT protects against oxidative stress and therefore both of these interventions can be beneficial for obese individuals; however, when combined, the effects cancel each other out.

  13. The Effect of the Peer-Review Technique on Students’ Writing Ability

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    Martin Kustati

    2014-10-01

    Full Text Available The  aim of this  study  was  to investigate  if  there could be a  significant positive effect by using Peer-Review Technique (PRT on students‟ ability in writing  English. An experimental research  method  was used in this study. A writing test based on the indicators of Jacobs et al. (1981 was completed by 65  undergraduate  students  in  English  from  the  English Department  at  the Faculty  of Education and Teacher Training in the  State Institute for Islamic Studies “Imam Bonjol‟  at  Padang.  The students  were divided into two groups:  an  experimental group (n=33 and  a  control group (n=32. Both groups  were similar in terms of academic level,  the  given writing task and their  target language  [English]   proficiency. The experimental participants were introduced to  Peer-Review  Technique in  essay writing sessions whilst the control group participants were taught through the teacher’s traditional feedback (TTF whereby  students worked individually to produce their texts. The findings  showed that PRT gave  a  significant  improvement  effect on  the students‟ writing abilities. This study is expected to serve as (1  data  for further  developing PRT; (2 input for  lecturers  in  writing  to  develop more effective and innovative learning; and (3  additional  material  for  the development of critical and cooperative learning theories in teaching writing.

  14. Dose-Volume Histogram Analysis of the Safety of Proton Beam Therapy for Unresectable Hepatocellular Carcinoma

    International Nuclear Information System (INIS)

    Kawashima, Mitsuhiko; Kohno, Ryosuke; Nakachi, Kohei; Nishio, Teiji; Mitsunaga, Shuichi; Ikeda, Masafumi; Konishi, Masaru; Takahashi, Shinichiro; Gotohda, Naoto; Arahira, Satoko; Zenda, Sadamoto; Ogino, Takashi; Kinoshita, Taira

    2011-01-01

    Purpose: To evaluate the safety and efficacy of radiotherapy using proton beam (PRT) for unresectable hepatocellular carcinoma. Methods and Materials: Sixty consecutive patients who underwent PRT between May 1999 and July 2007 were analyzed. There were 42 males and 18 females, with a median age of 70 years (48-92 years). All but 1 patient had a single lesion with a median diameter of 45 mm (20-100 mm). Total PRT dose/fractionation was 76-cobalt Gray equivalent (CGE)/20 fractions in 46 patients, 65 CGE/26 fractions in 11 patients, and 60 CGE/10 fractions in 3 patients. The risk of developing proton-induced hepatic insufficiency (PHI) was estimated using dose-volume histograms and an indocyanine-green retention rate at 15 minutes (ICG R15). Results: None of the 20 patients with ICG R15 of less than 20% developed PHI, whereas 6 of 8 patients with ICG R15 values of 50% or higher developed PHI. Among 32 patients whose ICG R15 ranged from 20% to 49.9%, PHI was observed only in patients who had received 30 CGE (V30) to more than 25% of the noncancerous parts of the liver (n = 5) Local progression-free and overall survival rates at 3 years were 90% (95% confidence interval [CI], 80-99%) and 56% (95% CI, 43-69%), respectively. A gastrointestinal toxicity of Grade ≥2 was observed in 3 patients. Conclusions: ICG R15 and V30 are recommended as useful predictors for the risk of developing PHI, which should be incorporated into multidisciplinary treatment plans for patients with this disease.

  15. Pattern of palliative care, pain management and referral trends in patients receiving radiotherapy at a tertiary cancer center

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    Kuldeep Sharma

    2009-01-01

    Full Text Available Background: Pain is a common primary symptom of advanced cancer and metastatic disease, occurring in 50-75% of all patients. Although palliative care and pain management are essential components in oncology practice, studies show that these areas are often inadequately addressed. Materials and Methods: We randomly selected 152 patients receiving palliative radiotherapy (PRT from October 2006 to August 2008, excluding metastatic bone lesions. Patients′ records were studied retrospectively. Results: A median follow-up of 21 weeks was available for 119 males and 33 females with a median age of 55 years. Maximum (60% patients were of head and neck cancers followed by esophagus (14%, lung (10% and others. Dysphagia, growth/ulcer and pain were the chief indications for PRT. Pain was present in 93 (61% cases out of which, 56 (60% were referred to pain clinic. All except one consulted pain clinic with a median pain score of 8 (0-10 point scale. Fifty-three of these 56 patients (96% received opioid-based treatment with adequate pain relief in 33% cases and loss of follow-up in 40% cases. Only five (3% cases were referred to a hospice. Twenty-two (14% cases were considered for radical treatment following excellent response to PRT. Conclusion: In this selective sample, the standard of analgesic treatment was found to be satisfactory. However, there is a lot of scope for improvement regarding referral to pain clinic and later to the hospice. Patients′ follow-up needs to be improved along with future studies evaluating those patients who were considered for further RT till radical dose. Programs to change the patients′ attitude towards palliative care, physicians′ (residents′ training to improve communication skills, and institutional policies may be promising strategies.

  16. Influence of evenness of poultry manure application on grain crops productivity

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    T. Yu. Anisimova

    2015-01-01

    Full Text Available Possibility of increase of efficiency of poultry manure application due to more evenness of fertilizer application into the soil was investigated. Machines with a wide range of regulation of an application rate, for example ROU-6 with interval from 4 to 80 t/ha are for this purpose necessary. Efficiency of poultry manure application for grain crops was increased due to using of machines of drum type with optimum doses fertilizing (12-16 t/ha. An assessment of efficiency was carried out. The drums rotation speed, shovel quantity and shape, their installation angle and a design of the directing board were determined. The developed modified working of a spreader of drum type allowed to reduce unevenness of width fertilizing by 12-14 percent, on length of unit pass - by 5 percent. It was established that if the dose increases more than 8 t/ha, the crop productivity growths not significant. At reduction of fertilizing unevenness from 97 to 72 percent yield losses decrease by 54.4 percent. At reduction of fertilizing unevenness more than 97 percent, efficiency worsens by 58 percent. Poultry manure spreading by the machine and tractor unit MTZ-82.1 + ROU-6M afforded an yield by 38 percent higher, in comparison with the machine and tractor unit T-150K + PRT-10. At decrease in unevenness from 82 to 43 percent of barley loss decreased by 29 percent. It was revealed that spreading by machine ROU-6M provided a yield increase by 8.6 percent more, than by machine PRT-10. Yield losses because of spreading unevenness made: by the PRT-10 operating - 30 percent; by the ROU-6M operating - 0.33 percent. The grain yield increase was higher thanks to more evenness of fertilizer application by ROU-6M with the new spreading working element.

  17. Independent and Combined Effects of Exercise and Vitamin D on Muscle Morphology, Function and Falls in the Elderly

    Directory of Open Access Journals (Sweden)

    Robin M. Daly

    2010-09-01

    Full Text Available Regular exercise, particularly progressive resistance training (PRT, is recognized as one of the most effective strategies to prevent age-related muscle loss (sarcopenia, but its effects on muscle function are mixed. However, emerging data indicates that high velocity PRT (fast concentric muscle contractions is more effective for improving functional outcomes than traditional PRT. In terms of falls prevention, high-challenging balance training programs appear to be most effective. There is also compelling evidence that supplemental vitamin D is an effective therapeutic option for falls prevention. The findings from a recent meta-analysis revealed that supplemental vitamin D at a dose of at least 700–1,000 IU/d or an achieved serum 25(OHD level of at least 60 nmol/L was associated with reduced falls risk among older individuals. Based on these findings, it is possible that the combination of exercise and vitamin D could have a synergistic effect on muscle morphology and function, particularly since both interventions have been shown to have beneficial effects on type II “fast twitch” muscle fibers and systemic inflammation, which have both been linked to losses in muscle mass and function. Unfortunately however, the findings from the limited number of factorial 2 × 2 design RCTs indicate that additional vitamin D does not enhance the effects of exercise on measures of muscle morphology, function or falls risk. However, none of these trials were adequately powered to detect a “synergistic” effect between the two treatment strategies, but it is likely that if an exercise-by-vitamin D interaction does exist, it may be limited to situations when vitamin D deficiency/insufficiency is corrected. Further targeted research in “high risk” groups is still needed to address this question, and evaluate whether there is a threshold level of serum 25(OHD to maximize the effects of exercise on muscle and falls risk.

  18. Hypophosphatemic osteomalacia induced by tenofovir in HIV-infected patients.

    Science.gov (United States)

    Mateo, Lourdes; Holgado, Susana; Mariñoso, Maria Luisa; Pérez-Andrés, Ricard; Bonjoch, Anna; Romeu, Joan; Olivé, Alejandro

    2016-05-01

    Tenofovir disoproxil fumarate (TDF) is an adenine analogue reverse transcription inhibitor widely used in first-line treatment of human immunodeficiency virus (HIV) infection and also in hepatitis B virus infection. Its use has been linked to sporadic Fanconi syndrome, renal failure and bone disease. We present the clinical characteristics of tenofovir-induced osteomalacia, discuss bone biopsy findings, describe predisposing factors and compare our results with other reported cases. We describe five cases of hypophosphatemic osteomalacia induced by TDF and recorded at the rheumatology service of a university hospital between 2010 and 2014. We also report the characteristics of bone biopsies of this pathology, which have not been previously described. We include a review of published cases of proximal renal tubulopathy (PRT) and osteomalacia induced by TDF (PubMed 1995-2014; keywords: osteomalacia, tenofovir, Fanconi syndrome, hypophosphatemic osteomalacia, proximal renal tubulopathy, bone biopsy). Five HIV patients who developed hypophosphatemic osteomalacia under TDF treatment (>5 years) presented increasing bone pain and a progressive inability to walk without assistance as a result of multiple insufficiency fractures. Bone biopsy performed in three patients after tetracycline labelling showed increased osteoid thickness, confirming osteomalacia. A literature review retrieved 17 publications on this condition, including 53 cases: 26 patients developed isolated PRT, 25 presented PRT and with multiple insufficiency fractures and two presented isolated bone disease, including osteomalacia and osteoporosis. Rheumatologists should be alert to this complication in patients receiving tenofovir. The main complaint reported by these patients is diffuse pain, predominantly in the lower limbs, indicating multiple stress fractures. Serum phosphate and appropriate screening for abnormal proximal tubule function should be monitored. Bone scintigraphy should be carried out in

  19. Swallowing therapy and progressive resistance training in head and neck cancer patients undergoing radiotherapy treatment

    DEFF Research Database (Denmark)

    Hajdú, Sara F; Wessel, Irene; Johansen, Christoffer

    2017-01-01

    BACKGROUND: Head and neck cancer (HNC) patients are often challenged by treatment induced dysphagia and trismus. Traditionally, rehabilitation is initiated when loss of function has already occurred. There is increasing evidence that it is of benefit to patients to initiate an early rehabilitation...... process before and during treatment. HNC patients have a unique set of functional challenges such as pre- and post-treatment dysphagia, pain and weight loss. The aim of the trial is to investigate the effects of swallowing and mouth-opening exercises combined with progressive resistance training (PRT...

  20. Creatine fails to augment the benefits from resistance training in patients with HIV infection: a randomized, double-blind, placebo-controlled study.

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    Giorgos K Sakkas

    Full Text Available Progressive resistance exercise training (PRT improves physical functioning in patients with HIV infection. Creatine supplementation can augment the benefits derived from training in athletes and improve muscle function in patients with muscle wasting. The objective of this study was to determine whether creatine supplementation augments the effects of PRT on muscle strength, energetics, and body composition in HIV-infected patients.This is a randomized, double blind, placebo-controlled, clinical research center-based, outpatient study in San Francisco. 40 HIV-positive men (20 creatine, 20 placebo enrolled in a 14-week study. Subjects were randomly assigned to receive creatine monohydrate or placebo for 14 weeks. Treatment began with a loading dose of 20 g/day or an equivalent number of placebo capsules for 5 days, followed by maintenance dosing of 4.8 g/day or placebo. Beginning at week 2 and continuing to week 14, all subjects underwent thrice-weekly supervised resistance exercise while continuing on the assigned study medication (with repeated 6-week cycles of loading and maintenance. The main outcome measurements included muscle strength (one repetition maximum, energetics ((31P magnetic resonance spectroscopy, composition and size (magnetic resonance imaging, as well as total body composition (dual-energy X-ray absorptiometry. Thirty-three subjects completed the study (17 creatine, 16 placebo. Strength increased in all 8 muscle groups studied following PRT, but this increase was not augmented by creatine supplementation (average increase 44 vs. 42%, difference 2%, 95% CI -9.5% to 13.9% in creatine and placebo, respectively. There were no differences between groups in changes in muscle energetics. Thigh muscle cross-sectional area increased following resistance exercise, with no additive effect of creatine. Lean body mass (LBM increased to a significantly greater extent with creatine. CONCLUSIONS / SIGNIFICANCE: Resistance exercise improved

  1. Progressive resistance training in head and neck cancer patients during concomitant chemoradiotherapy -- design of the DAHANCA 31 randomized trial.

    Science.gov (United States)

    Lonkvist, Camilla K; Lønbro, Simon; Vinther, Anders; Zerahn, Bo; Rosenbom, Eva; Primdahl, Hanne; Hojman, Pernille; Gehl, Julie

    2017-06-03

    Head and neck cancer patients undergoing concomitant chemoradiotherapy (CCRT) frequently experience loss of muscle mass and reduced functional performance. Positive effects of exercise training are reported for many cancer types but biological mechanisms need further elucidation. This randomized study investigates whether progressive resistance training (PRT) may attenuate loss of muscle mass and functional performance. Furthermore, biochemical markers and muscle biopsies will be investigated trying to link biological mechanisms to training effects. At the Departments of Oncology at Herlev and Aarhus University Hospitals, patients with stage III/IV squamous cell carcinoma of the head and neck, scheduled for CCRT are randomized 1:1 to either a 12-week PRT program or control group, both with 1 year follow-up. Planned enrollment is 72 patients, and stratification variables are study site, sex, p16-status, and body mass index. Primary endpoint is difference in change in lean body mass (LBM) after 12 weeks of PRT, assessed by dual-energy X-ray absorptiometry (DXA). The hypothesis is that 12 weeks of PRT can attenuate the loss of LBM by at least 25%. Secondary endpoints include training adherence, changes in body composition, muscle strength, functional performance, weight, adverse events, dietary intake, self-reported physical activity, quality of life, labor market affiliation, blood biochemistry, plasma cytokine concentrations, NK-cell frequency in blood, sarcomeric protein content in muscles, as well as muscle fiber type and fiber size in muscle biopsies. Muscle biopsies are optional. This randomized study investigates the impact of a 12-week progressive resistance training program on lean body mass and several other physiological endpoints, as well as impact on adverse events and quality of life. Furthermore, a translational approach is integrated with extensive biological sampling and exploration into cytokines and mechanisms involved. The current paper discusses

  2. Fractionated, three-dimensional, planning-assisted proton-radiation therapy for orbital rhabdomyosarcoma: a novel technique

    International Nuclear Information System (INIS)

    Hug, Eugen B.; Adams, Judy; Fitzek, Markus; Vries, Alexander de; Munzenrider, John E.

    2000-01-01

    Purpose: Most children with orbital rhabdomyosarcoma will survive their disease. However, conventional photon-radiation treatment, as part of multimodality therapy, results in varying degrees of long-term functional and cosmetic side effects. This report introduces external beam proton radiation therapy (PRT) as a conformal, three-dimensional planned radiation technique for this disease, analyzes normal tissue dosimetry, and describes the technique's application in the first 2 patients. Material and Methods: Between January 1995 and February 1996, 2 patients underwent PRT following biopsy and chemotherapy for orbital rhabdomyosarcoma. Fifty and 55 Cobalt Gray Equivalent (CGE) were delivered to the gross tumor volume and 40 CGE to clinical target volumes in both patients. A relative biologic effectiveness (RBE) of 1.1 was utilized to correlate proton dose calculations with CGE. To achieve dose conformity, a ''patch technique'' was utilized, where target regions were divided into segments, each treated by a separate proton field. Dose-volume histograms were obtained for target and nontarget regions, including lens, bony orbit, pituitary gland, optic chiasm, optic nerves, lacrimal gland, and ipsilateral frontal and temporal lobes. Results: At 3.4 and 2.5 years after PRT, both patients are clinically and radiographically free of disease. Visual acuity remains excellent, without signs of cataract formation; pituitary function is normal; cosmetically, only mild enophthalmos is noticeable. Doses to 90%, 50%, and 5% of lens volume were kept at less than 1%, less than 2%, and less than 8%, respectively. Fifty percent of lacrimal gland volume received less than 36% of the prescribed dose and 50% of the volume of the optic chiasm, pituitary gland, and hypothalamus were restricted to less than 2%. Proton conformity to orbital contents resulted in between 9% and 36% of the prescribed dose reaching the ipsilateral temporal and frontal lobes immediately adjacent to bony orbit (5

  3. Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple-sequence alignments.

    Science.gov (United States)

    Dietrich, Susanne; Borst, Nadine; Schlee, Sandra; Schneider, Daniel; Janda, Jan-Oliver; Sterner, Reinhard; Merkl, Rainer

    2012-07-17

    The analysis of a multiple-sequence alignment (MSA) with correlation methods identifies pairs of residue positions whose occupation with amino acids changes in a concerted manner. It is plausible to assume that positions that are part of many such correlation pairs are important for protein function or stability. We have used the algorithm H2r to identify positions k in the MSAs of the enzymes anthranilate phosphoribosyl transferase (AnPRT) and indole-3-glycerol phosphate synthase (IGPS) that show a high conn(k) value, i.e., a large number of significant correlations in which k is involved. The importance of the identified residues was experimentally validated by performing mutagenesis studies with sAnPRT and sIGPS from the archaeon Sulfolobus solfataricus. For sAnPRT, five H2r mutant proteins were generated by replacing nonconserved residues with alanine or the prevalent residue of the MSA. As a control, five residues with conn(k) values of zero were chosen randomly and replaced with alanine. The catalytic activities and conformational stabilities of the H2r and control mutant proteins were analyzed by steady-state enzyme kinetics and thermal unfolding studies. Compared to wild-type sAnPRT, the catalytic efficiencies (k(cat)/K(M)) were largely unaltered. In contrast, the apparent thermal unfolding temperature (T(M)(app)) was lowered in most proteins. Remarkably, the strongest observed destabilization (ΔT(M)(app) = 14 °C) was caused by the V284A exchange, which pertains to the position with the highest correlation signal [conn(k) = 11]. For sIGPS, six H2r mutant and four control proteins with alanine exchanges were generated and characterized. The k(cat)/K(M) values of four H2r mutant proteins were reduced between 13- and 120-fold, and their T(M)(app) values were decreased by up to 5 °C. For the sIGPS control proteins, the observed activity and stability decreases were much less severe. Our findings demonstrate that positions with high conn(k) values have an

  4. Elements of traditional Tuvan cosmology in the state emblem of the People’s Republic of Tuva, 1935-1939

    OpenAIRE

    Boris B. Mongush

    2016-01-01

    The article examines the constituent elements of the state emblem of the People’s Republic of Tuva (in its 1935/1939 version). We view state emblems as a special type of historical source where constituent emblems and elements are, in fact, reflections of a certain worldview. Emblems of the People’s Republic of Tuva (PRT) originally were full of Buddhist religious symbolism, but in the course of time it switched over to representing the dominance of the Soviet heraldic symbolism. Among the...

  5. Strain-specific impact of PsaR of Streptococcus pneumoniae on global gene expression and virulence

    OpenAIRE

    Hendriksen, Wouter T.; Bootsma, Hester J.; van Diepen, Angela; Estevao, Silvia; Kuipers, Oscar P.; de Groot, Ronald; Hermans, Peter W. M.

    2009-01-01

    Previous studies have indicated that PsaR of Streptococcus pneumoniae is a manganese-dependent regulator, negatively affecting the expression of at least seven genes. Here, we extended these observations by transcriptome and proteome analysis of psaR mutants in strains D39 and TIGR4. The microarray analysis identified three shared PsaR targets: the psa operon, pcpA and prtA. In addition, we found 31 genes to be regulated by PsaR in D39 only, most strikingly a cellobiose-specific phosphotrains...

  6. Application of a Microcomputer to a Mobile Electric Power Plant.

    Science.gov (United States)

    1980-05-28

    CIRCUITS, ADAPTIVE LOGIC .LRMFNTS SECTION CLASS CODES: C7551, C6120, C9950, C6240 TEE MOTIVATION FOR THIS IS THE POSSIBILITY OF USING SMALL GENERAL... PS4 7NTP1.JA’r~otAL coNliiiNcip ON CA! TURP7NPS (P1IPPRI’JTcS 1i8 1474 21 r Al;I - La A I P IL 19754 AFMF1 71PTCI1, SWIT?.PRT.ANn SuP!l.: As!1F NFIJ

  7. The Remote Sensing of Surface Radiative Temperature over Barbados.

    Science.gov (United States)

    remote sensing of surface radiative temperature over Barbados was undertaken using a PRT-5 attached to a light aircraft. Traverses across the centre of the island, over the rugged east coast area, and the urban area of Bridgetown were undertaken at different times of day and night in the last week of June and the first week of December, 1969. These traverses show that surface variations in long-wave radiation emission lie within plus or minus 5% of the observations over grass at a representative site. The quick response of the surface to sunset and sunrise was

  8. Dosimetric Comparison of Three-Dimensional Conformal Proton Radiotherapy, Intensity-Modulated Proton Therapy, and Intensity-Modulated Radiotherapy for Treatment of Pediatric Craniopharyngiomas

    Energy Technology Data Exchange (ETDEWEB)

    Boehling, Nicholas S. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Grosshans, David R., E-mail: dgrossha@mdanderson.org [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Bluett, Jaques B. [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Palmer, Matthew T. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Song, Xiaofei; Amos, Richard A.; Sahoo, Narayan [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Meyer, Jeffrey J.; Mahajan, Anita; Woo, Shiao Y. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)

    2012-02-01

    Purpose: Cranial irradiation in pediatric patients is associated with serious long-term adverse effects. We sought to determine whether both three-dimensional conformal proton radiotherapy (3D-PRT) and intensity-modulated proton therapy (IMPT) compared with intensity-modulated radiotherapy (IMRT) decrease integral dose to brain areas known to harbor neuronal stem cells, major blood vessels, and other normal brain structures for pediatric patients with craniopharyngiomas. Methods and Materials: IMRT, forward planned, passive scattering proton, and IMPT plans were generated and optimized for 10 pediatric patients. The dose was 50.4 Gy (or cobalt Gy equivalent) delivered in 28 fractions with the requirement for planning target volume (PTV) coverage of 95% or better. Integral dose data were calculated from differential dose-volume histograms. Results: The PTV target coverage was adequate for all modalities. IMRT and IMPT yielded the most conformal plans in comparison to 3D-PRT. Compared with IMRT, 3D-PRT and IMPT plans had a relative reduction of integral dose to the hippocampus (3D-PRT, 20.4; IMPT, 51.3%{sup Asterisk-Operator }), dentate gyrus (27.3, 75.0%{sup Asterisk-Operator }), and subventricular zone (4.5, 57.8%{sup Asterisk-Operator }). Vascular organs at risk also had reduced integral dose with the use of proton therapy (anterior cerebral arteries, 33.3{sup Asterisk-Operator }, 100.0%{sup Asterisk-Operator }; middle cerebral arteries, 25.9%{sup Asterisk-Operator }, 100%{sup Asterisk-Operator }; anterior communicating arteries, 30.8{sup Asterisk-Operator }, 41.7%{sup Asterisk-Operator }; and carotid arteries, 51.5{sup Asterisk-Operator }, 77.6{sup Asterisk-Operator }). Relative reduction of integral dose to the infratentorial brain (190.7{sup Asterisk-Operator }, 109.7%{sup Asterisk-Operator }), supratentorial brain without PTV (9.6, 26.8%{sup Asterisk-Operator }), brainstem (45.6, 22.4%{sup Asterisk-Operator }), and whole brain without PTV (19.4{sup Asterisk

  9. How does strength training and balance training affect gait and fatigue in patients with Multiple Sclerosis? A study protocol of a randomized controlled trial

    DEFF Research Database (Denmark)

    Callesen, Jacob Lynge; Brincks, John; Cattaneo, Davide

    2018-01-01

    with group and time as fixed effects and center and patient within center as random effects. Spearman or Pearson correlation analysis will be conducted on baseline data to determine associations between the primary outcomes on gait function and the secondary outcomes on fatigue, spatial gait parameters......Abstract: INTRODUCTION:Multiple sclerosis (MS) is characterized by a demyelination that results in reduced conductivity in the somatosensory nervous system, decreased muscle strength, vestibular alteration, and severe fatigue. Progressive resistance training (PRT) has proven to be a promising...

  10. Pupillary Response and Phenotype in ASD: Latency to Constriction Discriminates ASD from Typically Developing Adolescents.

    Science.gov (United States)

    Lynch, Georgina T F; James, Stephen M; VanDam, Mark

    2018-02-01

    Brain imaging data describe differences in the ASD brain, including amygdala overgrowth, neural interconnectivity, and a three-phase model of neuroanatomical changes from early post-natal development through late adolescence. The pupil reflex test (PRT), a noninvasive measure of brain function, may help improve early diagnosis and elucidate underlying physiology in expression of ASD endophenotype. Commonly observed characteristics of ASD include normal visual acuity but difficulty with eye gaze and photosensitivity, suggesting deficient neuromodulation of cranial nerves. Aims of this study were to confirm sensitivity of the PRT for identifying adolescents with ASD, determine if a phenotype for a subtype of ASD marked by pupil response is present in adolescence, and determine whether differences could be observed on a neurologic exam testing cranial nerves II and III (CNII; CNIII). Using pupillometry, constriction latency was measured serving as a proxy for recording neuromodulation of cranial nerves underlying the pupillary reflex. The swinging flashlight method, used to perform the PRT for measuring constriction latency and return to baseline, discriminated ASD participants from typically developing adolescents on 72.2% of trials. Results further confirmed this measure's sensitivity within a subtype of ASD in later stages of development, serving as a correlate of neural activity within the locus-coeruleus norepinephrine (LC-NE) system. A brainstem model of atypical PRT in ASD is examined in relation to modulation of cranial nerves and atypical arousal levels subserving the atypical pupillary reflex. Autism Res 2018, 11: 364-375. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Milder forms of autism spectrum disorder (ASD) can be difficult to diagnose based on behavioral testing alone. This study used eye-tracking equipment and a hand-held penlight to measure the pupil reflex in adolescents with "high functioning" ASD and in adolescents

  11. Communist Party Organs and Non-governmental Organizations in People’s Republic of Tuva during Great Patriotic war

    Directory of Open Access Journals (Sweden)

    Aldyn-ool K. Kanzay

    2017-12-01

    Full Text Available The article examines the main directions, forms and methods of work used by Revolutionary Party organs and non-governmental organizations of the People’s Republic of Tuva (PRT which helped ensure the participation of Tuvans in the Great Patriotic war of the USSR (WWII. To describe the forms and types of support the people of Tuva gave to the Soviet Union in its fight against the Nazi invaders, the author provides facts, statistics and quotations from Tuvan statesmen. These pieces of data come from both academically published sources and those found in the Central State Archives of the Republic of Tuva. The steps and measures initiated by the Revolutionary Party include the program of wartime rebuilding of the economy (adopted at the 2nd plenum of the Central Committee of Tuvan National Revolutionary Party (CC TNRP, June 26, 1941; plans of mass production of skis and warm clothes for the Red Army, of an increase in livestock and crop field areas, of enhancing competitive work and introducing ‘shock work’ practices (adopted at 3rd Plenum of CC TNRP, December 22, 1941; the resolution on the readiness to enlist Tuvan youth in the Red Army, adopted by the 3rd session of the PRT’s Small Khural, February 17, 1942; the joint order by the Cabinet of Ministers of PRT and the CC TNRP to set up a system of war training for the citizens of PRT and a national militia, adopted in July 1942; etc. The war years gave rise to a lot of grassroots initiatives of supporting the USSR, the most massive and fruitful among them being the movement to raise the money for the USSR’s Defense Fund. Donations included money transfers, providing spoils of the chase and livestock to the collective farms of Ukraine, and wheat and millet, to the Defense Fund. Among the donors were schools, Revolutionary Youth cells and private individuals. Mobilization in Tuva was accompanied by dedicated everyday organizational, explanatory and agitational work of the organs of the

  12. Area Handbook Series: Costa Rica, a Country Study.

    Science.gov (United States)

    1983-11-01

    the Independent Party (Partido Independiente -PI) to support his own candidacy, waged a campaign against the government’s financial irresponsi- bility...range Photo by James D. Rudolph ley, chiefly by small farmers, began only in the 1920s. The open- ing of the Inter-American Highway in the post -World...the country (see The Calder6n Era, ch. 1). In the post -World War 11 era, anticlericalism was no longer a major issue, in prt because many of the

  13. In vitro blood compatibility of poly (hydroxybutyrate-co-hydroxyhexanoate) and the influence of surface modification by alkali treatment

    International Nuclear Information System (INIS)

    Shen Feng; Zhang Erlin; Wei Zunjie

    2010-01-01

    In vitro blood compatibility of poly (hydroxybutyrate-co-hydroxyhexanoate) (PHBHHx) was evaluated in comparison with poly (L-lactic acid) (PLLA) by a haemolysis assay, in vitro platelet adhesion test and coagulation measurements including plasma recalcification time (PRT), plasma prothrombin time (PT) and kinetic clotting time. The results showed that PHBHHx exhibited better blood compatibility than PLLA. Furthermore, PHBHHx film was modified by NaOH treatment to improve the surface hydrophilic property and the influence of the surface modification on the blood compatibility was investigated. Surface properties including hydrophilic property, surface appearance and functional groups were characterized by water contact angle measurement, scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The results showed that the hydrophilic property of PHBHHx film was obviously improved by the NaOH treatment. It was also shown that the NaOH treatment could significantly enhance the blood compatibility of PHBHHx by prolonging PRT, PT, and kinetic clotting time and decreasing platelet activation. It is thought that the improvement in the hydrophilic property mainly contributes to the enhancement of blood compatibility.

  14. Equipos de reconstrucción provincial en Afganistán y el proceso de construcción de paz

    Directory of Open Access Journals (Sweden)

    Yuji Uesugi

    2009-06-01

    Full Text Available El derrocamiento del régimen taliban en Afganistán ha planteado enormes retos a las organizaciones que tienen por objetivo la reconstrucción física y el establecimiento de la democracia y el Estado de derecho en este país. Uno de los principales problemas es la situación de inseguridad que en muchas provincias todavía impide el trabajo de organizaciones que proveen ayuda humanitaria o asisten en proyectos de desarrollo. Para hacerle frente a esta situación se han creado los Equipos de Reconstrucción Provincial (PRT, compuestos tanto por personal civil como militar, los cuales buscan realizar proyectos que beneficien a la población afgana en regiones donde aún no pueden operar las organizaciones civiles convencionales. Este artículo presenta un análisis crítico de los PRT, explica las razones que llevaron a su creación, las críticas que ha recibido de parte de las organizaciones civiles y los retos que deben superar si se desea impulsar con ellos el desarrollo de Afganistán.

  15. Which benefits and harms of preoperative radiotherapy should be addressed? A Delphi consensus study among rectal cancer patients and radiation oncologists

    International Nuclear Information System (INIS)

    Kunneman, Marleen; Pieterse, Arwen H.; Stiggelbout, Anne M.; Marijnen, Corrie A.M.

    2015-01-01

    Background and purpose: We previously found considerable variation in information provision on preoperative radiotherapy (PRT) in rectal cancer. Our aims were to reach consensus among patients and oncologists on which benefits/harms of PRT should be addressed during the consultation, and to assess congruence with daily clinical practice. Materials and methods: A four-round Delphi-study was conducted with two expert panels: (1) 31 treated rectal cancer patients and (2) 35 radiation oncologists. Thirty-seven possible benefits/harms were shown. Participants indicated whether addressing the benefit/harm was (1) essential, (2) desired, (3) not necessary, or (4) to be avoided. Consensus was assumed when ⩾80% of the panel agreed. Results were compared to 81 audio-taped consultations. Results: The panels reached consensus that six topics should be addressed in all patients (local control, survival, long term altered defecation pattern and faecal incontinence, perineal wound healing problems, advice to avoid pregnancy), three in male patients (erectile dysfunction, ejaculation disorder, infertility), and four in female patients (vaginal dryness, pain during intercourse, menopause, infertility). On average, less than half of these topics were addressed in daily clinical practice. Conclusions: This study showed substantial overlap between benefits/harms that patients and oncologists consider important to address during the consultation, and at the same time poor congruence with daily clinical practice

  16. An Improved Clutter Suppression Method for Weather Radars Using Multiple Pulse Repetition Time Technique

    Directory of Open Access Journals (Sweden)

    Yingjie Yu

    2017-01-01

    Full Text Available This paper describes the implementation of an improved clutter suppression method for the multiple pulse repetition time (PRT technique based on simulated radar data. The suppression method is constructed using maximum likelihood methodology in time domain and is called parametric time domain method (PTDM. The procedure relies on the assumption that precipitation and clutter signal spectra follow a Gaussian functional form. The multiple interleaved pulse repetition frequencies (PRFs that are used in this work are set to four PRFs (952, 833, 667, and 513 Hz. Based on radar simulation, it is shown that the new method can provide accurate retrieval of Doppler velocity even in the case of strong clutter contamination. The obtained velocity is nearly unbiased for all the range of Nyquist velocity interval. Also, the performance of the method is illustrated on simulated radar data for plan position indicator (PPI scan. Compared with staggered 2-PRT transmission schemes with PTDM, the proposed method presents better estimation accuracy under certain clutter situations.

  17. Hemodynamic Based Coronary Artery Aneurysm Thrombosis Risk Stratification in Kawasaki Disease Patients

    Science.gov (United States)

    Grande Gutierrez, Noelia; Mathew, M.; McCrindle, B.; Kahn, A.; Burns, J.; Marsden, A.

    2017-11-01

    Coronary artery aneurysms (CAA) as a result of Kawasaki Disease (KD) put patients at risk for thrombosis and myocardial infarction. Current AHA guidelines recommend CAA diameter >8 mm or Z-score >10 as the criterion for initiating systemic anticoagulation. Our hypothesis is that hemodynamic data derived from computational blood flow simulations is a better predictor of thrombosis than aneurysm diameter alone. Patient-specific coronary models were constructed from CMRI for a cohort of 10 KD patients (5 confirmed thrombosis cases) and simulations with fluid structure interaction were performed using the stabilized finite element Navier-Stokes solver available in SimVascular. We used a closed-loop lumped parameter network (LPN) to model the heart and vascular boundary conditions coupled numerically to the flow solver. An automated parameter estimation method was used to match LPN values to clinical data for each patient. Hemodynamic data analysis resulted in low correlation between Wall Shear Stress (WSS)/ Particle Residence Time (PRT) and CAA diameter but demonstrates the positive correlation between hemodynamics and adverse patient outcomes. Our results suggest that quantifying WSS and PRT should enable identification of regions at higher risk of thrombosis. We propose a quantitative method to non-invasively assess the abnormal flow in CAA following KD that could potentially improve clinical decision-making regarding anticoagulation therapy.

  18. Development of an x-ray beam line at the NSLS for studies in materials science using x-ray absorption spectroscopy

    International Nuclear Information System (INIS)

    Sayers, D.E.

    1989-01-01

    At the time of the submission of the original proposal more than 7 years ago, the X-11 PRT had set as a goal to develop one of the leading and most comprehensive x-ray absorption beam lines in the world. By any measure we have been successful. As is well documented in previous annual progress report and in the NSLS annual reports, our PRT has been extremely productive in a wide range of topics in materials science, solid state physics, chemistry and biology. Well over 100 papers have been published acknowledging the support of this contract and this continues at a rate of about 30 papers per year and about 20 invited presentations per year. Significant in this report are major studies in high T c compounds, advances in interface studies, new results in premelting phenomena, several pioneering studies in application of XAS to electrochemistry and significant progress in our understanding of the structure of amorphous chalcogenide systems and their photostructural changes

  19. Effects of L-arginine immobilization on the anticoagulant activity and hemolytic property of polyethylene terephthalate films

    International Nuclear Information System (INIS)

    Liu Yun; Yang Yun; Wu Feng

    2010-01-01

    Surface modification of polyethylene terephthalate (PET) films was performed with L-arginine (L-Arg) to gain an improved anticoagulant surface. The surface chemistry changes of modified films were characterized by X-ray photoelectron spectroscopy (XPS) and attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy. The in vitro anticoagulant activities of the surface-modified PET films were evaluated by blood clotting test, hemolytic test, and the measurement of clotting time including plasma recalcification time (PRT), activated partial thromboplastin time (APTT), and prothrombin time (PT). The data of blood coagulation index (BCI) for L-arginine modified PET films (PET-Arg) was larger than that for PET at the same blood-sample contact time. The hemolysis ratio for PET-Arg was less than that for PET and within the accepted standard for biomaterials. The PRT and APTT for PET-Arg were significantly prolonged by 189 s and 25 s, respectively, compared to those for the unmodified PET. All results suggested that the currently described modification method could be a possible candidate to create antithrombogenic PET surfaces which would be useful for further medical applications.

  20. Considering patient values and treatment preferences enhances patient involvement in rectal cancer treatment decision making.

    Science.gov (United States)

    Kunneman, Marleen; Marijnen, Corrie A M; Baas-Thijssen, Monique C M; van der Linden, Yvette M; Rozema, Tom; Muller, Karin; Geijsen, Elisabeth D; Stiggelbout, Anne M; Pieterse, Arwen H

    2015-11-01

    The shared decision making (SDM) model states that patients' values and preferences should be clarified to choose a strategy that best fits the patient. This study aimed to assess whether values and preferences of rectal cancer patients are voiced and considered in deciding about preoperative radiotherapy (PRT), and whether this makes patients feel more involved in treatment decision making. Pre-treatment consultations of radiation oncologists and patients eligible for PRT were audiotaped (N=90). Tapes were transcribed and coded to identify patients' values and treatment preferences. Patients filled in a post-consultation questionnaire on their perceived involvement in decision making (N=60). Patients' values were voiced for 62/611 of benefits/harms addressed (10%), in 38/90 consultations (42%; maximum 4 values per consultation), and most often related to major long-term treatment outcomes. Patients' treatment preferences were discussed in 20/90 consultations (22%). In 16/90 consultations (18%), the oncologists explicitly indicated to consider patients' values or preferences. Patients perceived a significantly more active role in decision making if their values or preferences had been voiced or considered. Patients' values and treatment preferences are voiced or considered in a minority of consultations. If they are, this increases patients' perceived involvement in the decision making process. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  1. Effect of strontium tantalate surface texture on nickel nanoparticle dispersion by electroless deposition

    Energy Technology Data Exchange (ETDEWEB)

    Compean-González, C.L. [Universidad Autónoma de Nuevo León, Facultad de Ingeniería Civil, Departamento de Ecomateriales y Energía, Av. Universidad s/n, Ciudad Universitaria, San Nicolás de los Garza, Nuevo León C.P. 66451 (Mexico); Arredondo-Torres, V.M. [Facultad de Químico Farmacobiología, Universidad Michoacana de San Nicolás de Hidalgo, Tzintzuntzan #173, Col. Matamoros, Morelia, Michoacán C.P. 58240 (Mexico); Zarazúa-Morin, M.E. [Universidad Autónoma de Nuevo León, Facultad de Ingeniería Civil, Departamento de Ecomateriales y Energía, Av. Universidad s/n, Ciudad Universitaria, San Nicolás de los Garza, Nuevo León C.P. 66451 (Mexico); Figueroa-Torres, M.Z., E-mail: m.zyzlila@gmail.com [Universidad Autónoma de Nuevo León, Facultad de Ingeniería Civil, Departamento de Ecomateriales y Energía, Av. Universidad s/n, Ciudad Universitaria, San Nicolás de los Garza, Nuevo León C.P. 66451 (Mexico)

    2015-09-15

    Highlights: • Efficient short-time procedure for nickel nanoparticles dispersion by electroless. • Nanoparticles are spherical in shape with an average size of 15 nm. • Influence of surface texture on deposition temperature and time was observed. • Nickel deposition can be done below 50 °C. - Abstract: The present work studies the effect of smooth and porous texture of Sr{sub 2}Ta{sub 2}O{sub 7} on its surface modification with nickel nanoparticles through electroless deposition technique. The influence of temperature to control Ni nanoparticles loading amount and dispersion were analyzed. Nitrogen adsorption isotherms were used to examine surface texture characteristics. The morphology was observed by scanning electron microscopy (MEB) equipped with an energy dispersive spectrometry system (EDS), which was used to determine the amount of deposited Ni. The material with smooth texture (SMT) consists of big agglomerates of semispherical shape particles of 400 nm. Whilst the porous texture (PRT) exhibit a pore-wall formed of needles shape particles of around 200 nm in size. Results indicated that texture characteristics strongly influence the deposition reaction rate; for PRT oxide, Ni deposition can be done from 20 °C while for SMT oxide deposition begins at 40 °C. Analysis of Sr{sub 2}Ta{sub 2}O{sub 7} surface indicated that in both textures, Ni nanoparticles with spherical shape in the range of 10–20 nm were obtained.

  2. Lactocepin secreted by Lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines.

    Science.gov (United States)

    von Schillde, Marie-Anne; Hörmannsperger, Gabriele; Weiher, Monika; Alpert, Carl-Alfred; Hahne, Hannes; Bäuerl, Christine; van Huynegem, Karolien; Steidler, Lothar; Hrncir, Tomas; Pérez-Martínez, Gaspar; Kuster, Bernhard; Haller, Dirk

    2012-04-19

    The intestinal microbiota has been linked to inflammatory bowel diseases (IBD), and oral treatment with specific bacteria can ameliorate IBD. One bacterial mixture, VSL#3, containing Lactobacillus, Bifidobacterium, and Streptococcus, was clinically shown to reduce inflammation in IBD patients and normalize intestinal levels of IP-10, a lymphocyte-recruiting chemokine, in a murine colitis model. We identified Lactobacillus paracasei prtP-encoded lactocepin as a protease that selectively degrades secreted, cell-associated, and tissue-distributed IP-10, resulting in significantly reduced lymphocyte recruitment after intraperitoneal injection in an ileitis model. A human Lactobacillus casei isolate was also found to encode lactocepin and degrade IP-10. L. casei feeding studies in a murine colitis model (T cell transferred Rag2(-/-) mice) revealed that a prtP-disruption mutant was significantly less potent in reducing IP-10 levels, T cell infiltration and inflammation in cecal tissue compared to the isogenic wild-type strain. Thus, lactocepin-based therapies may be effective treatments for chemokine-mediated diseases like IBD. Copyright © 2012 Elsevier Inc. All rights reserved.

  3. Posterior urethral injuries associated with pelvic injuries in young adults: computerized finite element model creation and application to improve knowledge and prevention of these lesions.

    Science.gov (United States)

    Bréaud, J; Baqué, P; Loeffler, J; Colomb, F; Brunet, C; Thollon, L

    2012-05-01

    Young adult males involved in motorcycle accidents are particularly at risk for posterior urethral injury whenever pelvic injury occurs. Posterior urethral injuries remain problematic because their diagnosis may be missed, and during the initial treatment response the urethral injury can be aggravated by urethral catheterization. Few anatomical and clinical tools exist that establish a correlation between injuries and fractures of the pelvic ring and the risk of posterior urethral injury. Based on experience with traffic accident modeling, a computerized finite element model was conceived integrating the specific anatomic structures concerned. This model was extrapolated from a CAT scan of a young adult. The anatomic structures concerned in urethral and pelvic ring trauma (PRT) were isolated, placed in 3D and given biomechanical properties. The model was verified according to available experiments on PRT. To apply the model, we recreated a lateral impact mechanism on the pelvic ring. Stretching between the prostatic and membranous portions of the urethra (before and after visualization of a pelvic fracture) as well as timing of injury was studied. The model's application permitted us to analyze precisely the link between lateral impact trauma of the pelvic ring and lesions of the posterior urethra and to identify an urethra stretching prior to visualization of a pelvic fracture. Utilization of the model with other mechanisms of injury should allow for better comprehension of this associated trauma, improved prevention, iatrogenic aggravation of, and care for, these serious injuries. © Springer-Verlag 2011

  4. SlpE is a calcium-dependent cytotoxic metalloprotease associated with clinical isolates of Serratia marcescens.

    Science.gov (United States)

    Stella, Nicholas A; Callaghan, Jake D; Zhang, Liang; Brothers, Kimberly M; Kowalski, Regis P; Huang, Jean J; Thibodeau, Patrick H; Shanks, Robert M Q

    Serralysin-like proteases are found in a wide variety of bacteria. These metalloproteases are frequently implicated in virulence and are members of the widely conserved RTX-toxin family. We identified a serralysin-like protease in the genome of a clinical isolate of Serratia marcescens that is highly similar to the canonical serralysin protein, PrtS. This gene was named serralysin-like protease E, SlpE, and was found in the majority (67%) of tested clinical isolates, but was absent from most tested non-clinical isolates including the insect pathogen and reference S. marcescens strain Db11. Purified recombinant SlpE exhibited calcium-dependent protease activity similar to metalloproteases PrtS and SlpB. Induction of slpE in the low-protease-producing S. marcescens strain PIC3611 highly elevated extracellular protease activity, and extracellular secretion required the lipD type 1 secretion system gene. Transcription of slpE was highly reduced in an eepR transcription factor mutant. Mutation of the slpE gene in a highly proteolytic clinical isolate reduced its protease activity, and evidence suggests that SlpE confers cytotoxicity of S. marcescens to the A549 airway carcinoma cell line. Together, these data reveal SlpE to be an EepR-regulated cytotoxic metalloprotease associated with clinical isolates of an important opportunistic pathogen. Copyright © 2017 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

  5. Tension - Type - Headache treated by Positional Release Therapy: a case report.

    Science.gov (United States)

    Mohamadi, Marzieh; Ghanbari, Ali; Rahimi Jaberi, Abbas

    2012-10-01

    Tension Type Headache (T.T.H) is the most prevalent headache. Myofascial abnormalities & trigger points are important in this type of headache which can be managed by Positional Release Therapy (PRT). This is a report of a 47 years old female patient with Tension Type Headache treated by Positional Release Therapy for her trigger points. She had a constant dull headache, which continued all the day for 9 months. A physiotherapist evaluated the patient and found active trigger points in her cervical muscles. Then, she received Positional Release Therapy for her trigger points. After 3 treatment sessions, the patient's headache stopped completely. During the 8 months following the treatment she was without pain, and did not use any medication. Positional Release Therapy was effective in treating Tension Type Headache. This suggests that PRT could be an alternative treatment to medication in patients with T.T.H if the effectiveness of that can be confirmed by further studies. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. Simple and versatile molecular method of copy-number measurement using cloned competitors.

    Directory of Open Access Journals (Sweden)

    Hyun-Kyoung Kim

    Full Text Available Variations and alterations of copy numbers (CNVs and CNAs carry disease susceptibility and drug responsiveness implications. Although there are many molecular methods to measure copy numbers, sensitivity, reproducibility, cost, and time issues remain. In the present study, we were able to solve those problems utilizing our modified real competitive PCR method with cloned competitors (mrcPCR. First, the mrcPCR for ERBB2 copy number was established, and the results were comparable to current standard methods but with a shorter assay time and a lower cost. Second, the mrcPCR assays for 24 drug-target genes were established, and the results in a panel of NCI-60 cells were comparable to those from real-time PCR and microarray. Third, the mrcPCR results for FCGR3A and the FCGR3B CNVs were comparable to those by the paralog ratio test (PRT, but without PRT's limitations. These results suggest that mrcPCR is comparable to the currently available standard or the most sensitive methods. In addition, mrcPCR would be invaluable for measurement of CNVs in genes with variants of similar structures, because combination of the other methods is not necessary, along with its other advantages such as short assay time, small sample amount requirement, and applicability to all sequences and genes.

  7. A randomized trial comparison of the effects of verbal and pictorial naturalistic communication strategies on spoken language for young children with autism.

    Science.gov (United States)

    Schreibman, Laura; Stahmer, Aubyn C

    2014-05-01

    Presently there is no consensus on the specific behavioral treatment of choice for targeting language in young nonverbal children with autism. This randomized clinical trial compared the effectiveness of a verbally-based intervention, Pivotal Response Training (PRT) to a pictorially-based behavioral intervention, the Picture Exchange Communication System (PECS) on the acquisition of spoken language by young (2-4 years), nonverbal or minimally verbal (≤9 words) children with autism. Thirty-nine children were randomly assigned to either the PRT or PECS condition. Participants received on average 247 h of intervention across 23 weeks. Dependent measures included overall communication, expressive vocabulary, pictorial communication and parent satisfaction. Children in both intervention groups demonstrated increases in spoken language skills, with no significant difference between the two conditions. Seventy-eight percent of all children exited the program with more than 10 functional words. Parents were very satisfied with both programs but indicated PECS was more difficult to implement.

  8. Comparison of photobiomodulation therapy and suprascapular nerve-pulsed radiofrequency in chronic shoulder pain: a randomized controlled, single-blind, clinical trial.

    Science.gov (United States)

    Ökmen, Burcu Metin; Ökmen, Korgün

    2017-11-01

    Shoulder pain can be difficult to treat due to its complex anatomic structure, and different treatment methods can be used. We aimed to examine the efficacy of photobiomodulation therapy (PBMT) and suprascapular nerve (SSN)-pulsed radiofrequency (RF) therapy. In this prospective, randomized, controlled, single-blind study, 59 patients with chronic shoulder pain due to impingement syndrome received PBMT (group H) or SSN-pulsed RF therapy (group P) in addition to exercise therapy for 14 sessions over 2 weeks. Records were taken using visual analog scale (VAS), Shoulder Pain and Disability Index (SPADI), and Nottingham Health Profile (NHP) scoring systems for pretreatment (PRT), posttreatment (PST), and PST follow-up at months 1, 3, and 6. There was no statistically significant difference in initial VAS score, SPADI, and NHP values between group H and group P (p > 0.05). Compared to the values of PRT, PST, and PST at months 1, 3, and 6, VAS, SPADI, and NHP values were statistically significantly lower in both groups (p measurement times in VAS, SPADI, and NHP between the two groups. We established that PBMT and SSN-pulsed RF therapy are effective methods, in addition to exercise therapy, in patients with chronic shoulder pain. PBMT seems to be advantageous compared to SSN-pulsed RF therapy, as it is a noninvasive method.

  9. PRESENTASI DIRI PEKERJA RUMAH TANGGA PADA SITUS JEJARING SOSIAL FACEBOOK

    Directory of Open Access Journals (Sweden)

    Nuria Astagini

    2016-08-01

    Full Text Available Abstrak Pengguna situs jejaring sosial Facebook kini sudah merambah berbagai kalangan, mulai dari pemimpin negara, hingga para pekerja rumah tangga (PRT. Meski sering diasosiasikan sebagai kalangan kelas bawah, para pekerja rumah tangga  ini merupakan pengguna aktif situs jejaring sosial. Melalui metode penelitian kualitatif dengan wawancara mendalam kepada informan yang berprofesi sebagai pekerja rumah tangga; diketahui bahwa mereka menggunakan situs jejaring sosial Facebook karena Facebook telah menjadi pengganti sahabat atau teman dekat yang mereka miliki di dunia nyata. Oleh karena itu penting bagi informan untuk menampilkan diri secara berbeda pada halaman profil Facebook mereka. Kedua informan mempresentasikan diri pada situs jejaring sosial ini sesuai dengan peran, naskah dan kostum mereka masing-masing.  Hal ini terlihat melalui berbagai konten yang mereka unggah, interaksi yang terjalin melalui halaman profil dan foto-foto yag ditampilkan pada profil mereka. Adapun terkait dengan profesi mereka sebagai PRT, keduanya sama-sama melemahkan stigma negatif dengan tidak mengasosiasikan profil mereka dengan profesi sebagai pekerja rumah tangga. Keberhasilan pengelolaan kesan pada panggung depan dinilai melalui tanda suka (like dan komentar positif yang diberikan audience kepada informan. Bagi informan kedua hal ini merupakan bentuk perhatian dan penerimaan yang diberikan kepada mereka Kata kunci:Pekerja Rumah Tangga, Domestik, Facebook, Situs Jejaring Sosial, Presentasi Diri, Dramaturgi

  10. Laser light and magnetic field stimulation effect on biochemical, enzymes activities and chlorophyll contents in soybean seeds and seedlings during early growth stages.

    Science.gov (United States)

    Asghar, Tehseen; Jamil, Yasir; Iqbal, Munawar; Zia-Ul-Haq; Abbas, Mazhar

    2016-12-01

    Laser and magnetic field bio-stimulation attracted the keen interest of scientific community in view of their potential to enhance seed germination, seedling growth, physiological, biochemical and yield attributes of plants, cereal crops and vegetables. Present study was conducted to appraise the laser and magnetic field pre-sowing seed treatment effects on soybean sugar, protein, nitrogen, hydrogen peroxide (H 2 O 2 ) ascorbic acid (AsA), proline, phenolic and malondialdehyde (MDA) along with chlorophyll contents (Chl "a" "b" and total chlorophyll contents). Specific activities of enzymes such as protease (PRT), amylase (AMY), catalyst (CAT), superoxide dismutase (SOD) and peroxides (POD) were also assayed. The specific activity of enzymes (during germination and early growth), biochemical and chlorophyll contents were enhanced significantly under the effect of both laser and magnetic pre-sowing treatments. Magnetic field treatment effect was slightly higher than laser treatment except PRT, AMY and ascorbic acid contents. However, both treatments (laser and magnetic field) effects were significantly higher versus control (un-treated seeds). Results revealed that laser and magnetic field pre-sowing seed treatments have potential to enhance soybean biological moieties, chlorophyll contents and metabolically important enzymes (degrade stored food and scavenge reactive oxygen species). Future study should be focused on growth characteristics at later stages and yield attributes. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. A case study employing operant conditioning to reduce stress of capture for red-bellied tamarins (Saguinus labiatus).

    Science.gov (United States)

    Owen, Yvonne; Amory, Jonathan R

    2011-01-01

    Traditional techniques used to capture New World monkeys, such as net capture, can induce high levels of acute stress detrimental to welfare. Alternatively, training nonhuman animals via operant conditioning to voluntarily participate in husbandry and/or veterinary practices is accepted as a humane process that can reduce stress and improve welfare. This study details the use of operant conditioning using positive reinforcement training (PRT) and target training to train a family of 5 captive red-bellied tamarins (Saguinus labiatus) in a wildlife park to voluntarily enter a transportation box and remain calm for 1 min after 54 training sessions. Observations of 2 unrelated net-capture processes provided measures of locomotion and vocalizations as indicators of stress behavior that were compared with those of the trained tamarins. Net-captured monkeys exhibited rapid erratic locomotion and emitted long, high-frequency vocalizations during capture whereas the trained tamarins exhibited minimal locomotion and emitted only 4 brief vocalizations (root mean square 35 dB) during capture. This indicates that the use of PRT considerably reduced potential for stress and improved welfare during the capture and containment of the tamarins. Copyright © Taylor & Francis Group, LLC

  12. Practical reporting times for environmental samples

    International Nuclear Information System (INIS)

    Bayne, C.K.; Schmoyer, D.D.; Jenkins, R.A.

    1993-02-01

    Preanalytical holding times for environmental samples are specified because chemical and physical characteristics may change between sampling and chemical analysis. For example, the Federal Register prescribes a preanalytical holding time of 14 days for volatile organic compounds in soil stored at 4 degrees C. The American Society for Testing Materials (ASTM) uses a more technical definition that the preanalytical holding time is the day when the analyte concentration for an environmental sample falls below the lower 99% confidence interval on the analyte concentration at day zero. This study reviews various holding time definitions and suggest a new preanalytical holding time approach using acceptable error rates for measuring an environmental analyte. This practical reporting time (PRT) approach has been applied to nineteen volatile organic compounds and four explosives in three environmental soil samples. A PRT nomograph of error rates has been developed to estimate the consequences of missing a preanalytical holding time. This nomograph can be applied to a large class of analytes with concentrations that decay linearly or exponentially with time regardless of sample matrices and storage conditions

  13. Practical reporting times for environmental samples

    Energy Technology Data Exchange (ETDEWEB)

    Bayne, C.K.; Schmoyer, D.D.; Jenkins, R.A.

    1993-02-01

    Preanalytical holding times for environmental samples are specified because chemical and physical characteristics may change between sampling and chemical analysis. For example, the Federal Register prescribes a preanalytical holding time of 14 days for volatile organic compounds in soil stored at 4{degrees}C. The American Society for Testing Materials (ASTM) uses a more technical definition that the preanalytical holding time is the day when the analyte concentration for an environmental sample falls below the lower 99% confidence interval on the analyte concentration at day zero. This study reviews various holding time definitions and suggest a new preanalytical holding time approach using acceptable error rates for measuring an environmental analyte. This practical reporting time (PRT) approach has been applied to nineteen volatile organic compounds and four explosives in three environmental soil samples. A PRT nomograph of error rates has been developed to estimate the consequences of missing a preanalytical holding time. This nomograph can be applied to a large class of analytes with concentrations that decay linearly or exponentially with time regardless of sample matrices and storage conditions.

  14. RANS Modeling of Stably Stratified Turbulent Boundary Layer Flows in OpenFOAM®

    Directory of Open Access Journals (Sweden)

    Wilson Jordan M.

    2015-01-01

    Full Text Available Quantifying mixing processes relating to the transport of heat, momentum, and scalar quantities of stably stratified turbulent geophysical flows remains a substantial task. In a stably stratified flow, such as the stable atmospheric boundary layer (SABL, buoyancy forces have a significant impact on the flow characteristics. This study investigates constant and stability-dependent turbulent Prandtl number (Prt formulations linking the turbulent viscosity (νt and diffusivity (κt for modeling applications of boundary layer flows. Numerical simulations of plane Couette flow and pressure-driven channel flow are performed using the Reynolds-averaged Navier-Stokes (RANS framework with the standard k-ε turbulence model. Results are compared with DNS data to evaluate model efficacy for predicting mean velocity and density fields. In channel flow simulations, a Prandtl number formulation for wall-bounded flows is introduced to alleviate overmixing of the mean density field. This research reveals that appropriate specification of Prt can improve predictions of stably stratified turbulent boundary layer flows.

  15. Heat Transfer Characteristics and Prediction Model of Supercritical Carbon Dioxide (SC-CO2 in a Vertical Tube

    Directory of Open Access Journals (Sweden)

    Can Cai

    2017-11-01

    Full Text Available Due to its distinct capability to improve the efficiency of shale gas production, supercritical carbon dioxide (SC-CO2 fracturing has attracted increased attention in recent years. Heat transfer occurs in the transportation and fracture processes. To better predict and understand the heat transfer of SC-CO2 near the critical region, numerical simulations focusing on a vertical flow pipe were performed. Various turbulence models and turbulent Prandtl numbers (Prt were evaluated to capture the heat transfer deterioration (HTD. The simulations show that the turbulent Prandtl number model (TWL model combined with the Shear Stress Transport (SST k-ω turbulence model accurately predicts the HTD in the critical region. It was found that Prt has a strong effect on the heat transfer prediction. The HTD occurred under larger heat flux density conditions, and an acceleration process was observed. Gravity also affects the HTD through the linkage of buoyancy, and HTD did not occur under zero-gravity conditions.

  16. Scalable Fault-Tolerant Location Management Scheme for Mobile IP

    Directory of Open Access Journals (Sweden)

    JinHo Ahn

    2001-11-01

    Full Text Available As the number of mobile nodes registering with a network rapidly increases in Mobile IP, multiple mobility (home of foreign agents can be allocated to a network in order to improve performance and availability. Previous fault tolerant schemes (denoted by PRT schemes to mask failures of the mobility agents use passive replication techniques. However, they result in high failure-free latency during registration process if the number of mobility agents in the same network increases, and force each mobility agent to manage bindings of all the mobile nodes registering with its network. In this paper, we present a new fault-tolerant scheme (denoted by CML scheme using checkpointing and message logging techniques. The CML scheme achieves low failure-free latency even if the number of mobility agents in a network increases, and improves scalability to a large number of mobile nodes registering with each network compared with the PRT schemes. Additionally, the CML scheme allows each failed mobility agent to recover bindings of the mobile nodes registering with the mobility agent when it is repaired even if all the other mobility agents in the same network concurrently fail.

  17. Fiscal instruments for regulating the sustainable development of urban transport systems in Russia

    Science.gov (United States)

    Mayburov, I.; Leontyeva, Y.

    2017-06-01

    The article explains the role of public transport pricing. It proves the need for a systemic approach to building a modern public transit system. The authors argue that the main objective of the approach should be to reduce the use of private vehicles in the urban environment and increasing public transport use. It is proven that for the consumer of transport services the price per trip is an important factor when deciding whether to travel by car or by public transport. The authors analyze the available literature assessing the effects of widespread car ownership on users of the city transit system. Conflict situations that occur due to the unabated desire of city residents to travel by car are analyzed. A research method is proposed. It is shown that public transport fares have been growing in Russia at an accelerated pace when compared to the overall increase in prices of all goods and services, including motor vehicles, petrol and oils. The fare growth has resulted in a 3.6 fold drop in demand for public transport services over the 15 years being analyzed. Over the same period, the number of privately owned cars grew 120 percent. A conclusion is drawn that regular fare hikes have encouraged urban population to gradually opt against travelling by public transport. That resulted in higher demand for car travel and, eventually, in an accelerated growth in car usage. One can conclude that a persistent institutional trap has taken shape in Russian metropolises. Essentially, it means that higher public transport fares have led to lower demand for public transit services. As ridership goes down, public transport operators have to again increase prices, thus driving the demand for their services down. It is proven that escaping the trap will require restoring the ratio of prices to make sure that the price charged for a public transport trip is far lower than the cost of travelling by car. The aim of this study is to assess the influence of the factor of public

  18. Towards Energy Efficient and Shared Mobility Services

    Energy Technology Data Exchange (ETDEWEB)

    Rames, Clement L [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-10-24

    Throughout the 20th century, automobiles have shaped urban and suburban landscapes, especially in North America. Globally, the car-centric transportation paradigm has contributed to unprecedented issues in terms of air quality, fossil-fuel dependence, carbon emissions lock-in, traffic congestion, road safety, parking scarcity, serious public health concerns, and socioeconomic inequality. Nonetheless, in the United States the percentage of single-occupant vehicle (SOV) commuters has continued to rise since 1960 while the proportion of carpooling has decreased by more than half since 1980. Evolving mobility services, in conjunction with new behavioral insights, have motivated recent inquiries in how to best foster sustainable growth while reducing traffic congestion and improving health outcomes. Few studies have assessed their true effectiveness, unanticipated effects (e.g., 'dead-head' or 'empty-vehicle' ride-hailing trips) or measured their impact on a specific city (e.g., modal shift, changes in personal miles traveled/vehicle miles traveled). This effort aims to answer the following questions: to what extent can shared mobility help invert the trend of increasing SOV trips? What are the energy risks and benefits of shared mobility? How do interactions between technology, policy, urban design, and behavioral change shape the transition to energy-efficient transportation? To this end, an assessment framework for sustainable urban mobility is developed, incorporating behavioral metrics (percent active transportation, percent transit ridership, percent shared trips), energy use (vehicle miles traveled per capita, percent SOV trips) and urban planning (population density, average commute time). We apply this framework to three cities (Denver, CO; San Francisco, CA; and Paris, France) to evaluate the sustainability of their transportation systems and explore their potential for shared mobility. The influence of incentives, social norms, and public

  19. Remote sensing, geographical information systems, and spatial modeling for analyzing public transit services

    Science.gov (United States)

    Wu, Changshan

    Public transit service is a promising transportation mode because of its potential to address urban sustainability. Current ridership of public transit, however, is very low in most urban regions, particularly those in the United States. This woeful transit ridership can be attributed to many factors, among which poor service quality is key. Given this, there is a need for transit planning and analysis to improve service quality. Traditionally, spatially aggregate data are utilized in transit analysis and planning. Examples include data associated with the census, zip codes, states, etc. Few studies, however, address the influences of spatially aggregate data on transit planning results. In this research, previous studies in transit planning that use spatially aggregate data are reviewed. Next, problems associated with the utilization of aggregate data, the so-called modifiable areal unit problem (MAUP), are detailed and the need for fine resolution data to support public transit planning is argued. Fine resolution data is generated using intelligent interpolation techniques with the help of remote sensing imagery. In particular, impervious surface fraction, an important socio-economic indicator, is estimated through a fully constrained linear spectral mixture model using Landsat Enhanced Thematic Mapper Plus (ETM+) data within the metropolitan area of Columbus, Ohio in the United States. Four endmembers, low albedo, high albedo, vegetation, and soil are selected to model heterogeneous urban land cover. Impervious surface fraction is estimated by analyzing low and high albedo endmembers. With the derived impervious surface fraction, three spatial interpolation methods, spatial regression, dasymetric mapping, and cokriging, are developed to interpolate detailed population density. Results suggest that cokriging applied to impervious surface is a better alternative for estimating fine resolution population density. With the derived fine resolution data, a multiple

  20. Dynamical Predictability of Monthly Means.

    Science.gov (United States)

    Shukla, J.

    1981-12-01

    We have attempted to determine the theoretical upper limit of dynamical predictability of monthly means for prescribed nonfluctuating external forcings. We have extended the concept of `classical' predictability, which primarily refers to the lack of predictability due mainly to the instabilities of synoptic-scale disturbances, to the predictability of time averages, which are determined by the predictability of low-frequency planetary waves. We have carded out 60-day integrations of a global general circulation model with nine different initial conditions but identical boundary conditions of sea surface temperature, snow, sea ice and soil moisture. Three of these initial conditions are the observed atmospheric conditions on 1 January of 1975, 1976 and 1977. The other six initial conditions are obtained by superimposing over the observed initial conditions a random perturbation comparable to the errors of observation. The root-mean-square (rms) error of random perturbations at all the grid points and all the model levels is 3 m s1 in u and v components of wind. The rms vector wind error between the observed initial conditions is >15 m s1.It is hypothesized that for a given averaging period, if the rms error among the time averages predicted from largely different initial conditions becomes comparable to the rms error among the time averages predicted from randomly perturbed initial conditions, the time averages are dynamically unpredictable. We have carried out the analysis of variance to compare the variability, among the three groups, due to largely different initial conditions, and within each group due to random perturbations.It is found that the variances among the first 30-day means, predicted from largely different initial conditions, are significantly different from the variances due to random perturbations in the initial conditions, whereas the variances among 30-day means for days 31-60 are not distinguishable from the variances due to random initial

  1. Bowen ratio/energy balance technique for estimating crop net CO2 assimilation, and comparison with a canopy chamber

    Science.gov (United States)

    Held, A. A.; Steduto, P.; Orgaz, F.; Matista, A.; Hsiao, T. C.

    1990-12-01

    This paper describes a Bowen ratio/energy balance (BREB) system which, in conjunction with an infra-red gas analyzer (IRGA), is referred to as BREB+ and is used to estimate evapotranspiration ( ET) and net CO2 flux ( NCF) over crop canopies. The system is composed of a net radiometer, soil heat flux plates, two psychrometers based on platinum resistance thermometers (PRT), bridge circuits to measure resistances, an IRGA, air pumps and switching valves, and a data logger. The psychrometers are triple shielded and aspirated, and with aspiration also between the two inner shields. High resistance (1 000 ohm) PRT's are used for dry and wet bulbs to minimize errors due to wiring and connector resistances. A high (55 K ohm) fixed resistance serves as one arm of the resistance bridge to ensure linearity in output signals. To minimize gaps in data, to allow measurements at short (e.g., 5 min) intervals, and to simplify operation, the psychrometers were fixed at their upper and lower position over the crop and not alternated. Instead, the PRT's, connected to the bridge circuit and the data logger, were carefully calibrated together. Field tests using a common air source showed appartent effects of the local environment around each psychrometer on the temperatures measured. ET rates estimated with the BREB system were compared to those measured with large lysimeters. Daily totals agreed within 5%. There was a tendency, however, for the lysimeter measurements to lag behind the BREB measurements. Daily patterns of NCF estimated with the BREB+ system are consistent with expectations from theories and data in the literature. Side-by-side comparisons with a stirred Mylar canopy chamber showed similar NCF patterns. On the other hand, discrepancies between the results of the two methods were quite marked in the morning or afternoon on certain dates. Part of the discrepancies may be attributed to inaccuracies in the psychrometric temperature measurements. Other possible causes

  2. The collection of Tuvan stamps (1926–1943 in the National Museum of the Republic of Tuva and the prospects of philately in Tuva

    Directory of Open Access Journals (Sweden)

    Kaadyr-ool A. Bicheldey

    2016-09-01

    Full Text Available Stamps of the People’s Republic of Tuva (PRT, 1921-1944 as indicia and as items of collectors’ interest, are universally renowned, and as such have been the subject of a good deal of research. These works contain more than a mere story of Tuvan stamps – they provide a lot of useful information on Tuva, its history, including the history of postal service in the region. This article describes the collection of indicia (more than 500 pieces dated 1926-1943 and preserved at Aldan Maadyr National Museum of Tuva. On the basis of this analysis we have formulated the current problems and prospects of philately in the region. The stamp collection in the National Museum fills 4 albums of various sizes and a number of envelopes with 1-72 stamps in each. The compilers of 2 albums attempted to systematize stamps by issue date, but this work is far from complete. There is no definitive collection of Tuvan stamps to act as a model for others, regardless of the quality of the stamps preserved. The rest of the stamps in the museum collection is in unsorted state. Overall, the degree of preservation can be tentatively described as average. Given the great interest of scholars and collectors, Tuvan stamps are relatively little studies. The overall bulk of material on the uses of stamps in Tuva lacks an overarching study. We have summed up the main research problems that call for in-depth research, including studying Tuvan stamps as pieces of art, the financial and economic viability of issuing stamps in PRT, the official documentations licensing the issue, full catalogization of all existing issues, the study of individual stamps, etc. Especially urgent is the issue of propagating knowledge of history of Tuvan postal service as a precondition for collecting and preserving PRT stamps. Archives of many Tuvan families may contain unique stamps, rare envelopes or postcards – but few of their owners recognize the full value of what they have. This puts unique

  3. DIMENSI-DIMENSI PERLINDUNGAN HUKUM BAGI PEKERJA RUMAH TANGGA DI ERA INDUSTRIALISAI

    Directory of Open Access Journals (Sweden)

    Briliyan Erna Wati

    2016-03-01

    Full Text Available Pekerja Rumah Tangga (PRT adalah kelompok marginalyang paling rentan terhadap kelalaian yang dilakukanoleh majikan. Hal ini terbukti dengan tidak adanyakejelasan hukum atau perlindungan bagi status mereka.Seharusnya jaminan konstitusional sebagai bentukkepedulian negara untuk memberikan perlindunganekonomi, sosial serta keadilan dan kesejahteraan bagipekerja rumah tangga sudah ada sejak kemerdekaanIndonesia. Artikel ini bertujuan untuk menunjukkanbetapa pentingnya regulasi perlindungan pekerjarumah tangga. Temuan dari artikel ini adalah bahwaada berbagai alasan baik normatif, hukum dan bahkanpraktis yang menunjukkan bahwa perlindungan hukumbagi pekerja rumah tangga harus diatur dalam undangundangkhusus dan harus direalisasikan. Pertama,keberadaan undang-undang tentang pekerja rumah tangga sebagai bentuk perlindungan hukum bagi pekerja rumah tangga sebagai titik tolak bagi pemerintah untuksecara bertahap merubah status hukum Pekerja RumahTangga (sebagai pekerja non formal menjadi pekerja formal. Pergeseran ini penting karena itu berdampakpositif pada nilai ekonomi mereka. kata kunci: Pekerja Rumah Tangga, PerlindunganHukum, Peraturan   Household Workers (PRT are marginal groups whichare the most vulnerable to the abuse of the employer.This proved by the absence of legal clarity or protectionfor their work. Constitutional Guarantees  as a formof  state contracts in order to provide Economical andSocial protection as well as justice and welfare for humanincluding domestic workers should be a fundamentalregulation since Indonesian independence. This articleaimed to show how important is the regulation in terms ofhousehold worker protection. The finding of this article isthat the existence of normative , legal and even practicalreasons to strengthen the argument that the protection ofthe law for domestic workers should be regulated in thelegislation specifically in  Drafts or Bill on Protection of Household Workers. There are many reasons

  4. Standardizing operational vector sampling techniques for measuring malaria transmission intensity: evaluation of six mosquito collection methods in western Kenya.

    Science.gov (United States)

    Wong, Jacklyn; Bayoh, Nabie; Olang, George; Killeen, Gerry F; Hamel, Mary J; Vulule, John M; Gimnig, John E

    2013-04-30

    Operational vector sampling methods lack standardization, making quantitative comparisons of malaria transmission across different settings difficult. Human landing catch (HLC) is considered the research gold standard for measuring human-mosquito contact, but is unsuitable for large-scale sampling. This study assessed mosquito catch rates of CDC light trap (CDC-LT), Ifakara tent trap (ITT), window exit trap (WET), pot resting trap (PRT), and box resting trap (BRT) relative to HLC in western Kenya to 1) identify appropriate methods for operational sampling in this region, and 2) contribute to a larger, overarching project comparing standardized evaluations of vector trapping methods across multiple countries. Mosquitoes were collected from June to July 2009 in four districts: Rarieda, Kisumu West, Nyando, and Rachuonyo. In each district, all trapping methods were rotated 10 times through three houses in a 3 × 3 Latin Square design. Anophelines were identified by morphology and females classified as fed or non-fed. Anopheles gambiae s.l. were further identified as Anopheles gambiae s.s. or Anopheles arabiensis by PCR. Relative catch rates were estimated by negative binomial regression. When data were pooled across all four districts, catch rates (relative to HLC indoor) for An. gambiae s.l (95.6% An. arabiensis, 4.4% An. gambiae s.s) were high for HLC outdoor (RR = 1.01), CDC-LT (RR = 1.18), and ITT (RR = 1.39); moderate for WET (RR = 0.52) and PRT outdoor (RR = 0.32); and low for all remaining types of resting traps (PRT indoor, BRT indoor, and BRT outdoor; RR < 0.08 for all). For Anopheles funestus, relative catch rates were high for ITT (RR = 1.21); moderate for HLC outdoor (RR = 0.47), CDC-LT (RR = 0.69), and WET (RR = 0.49); and low for all resting traps (RR < 0.02 for all). At finer geographic scales, however, efficacy of each trap type varied from district to district. ITT, CDC-LT, and WET appear to be effective methods for large-scale vector sampling in

  5. Fractionation of Palliative Radiation Therapy for Bone Metastases in Ontario: Do Practice Guidelines Guide Practice?

    Energy Technology Data Exchange (ETDEWEB)

    Ashworth, Allison [Division of Cancer Care and Epidemiology, Queen' s Cancer Research Institute, Queen' s University, Kingston, Ontario (Canada); Cancer Center of Southeastern Ontario, Kingston, Ontario (Canada); Kong, Weidong [Division of Cancer Care and Epidemiology, Queen' s Cancer Research Institute, Queen' s University, Kingston, Ontario (Canada); Chow, Edward [Sunnybrook Regional Cancer Centre, Toronto, Ontario (Canada); Mackillop, William J., E-mail: william.mackillop@krcc.on.ca [Division of Cancer Care and Epidemiology, Queen' s Cancer Research Institute, Queen' s University, Kingston, Ontario (Canada); Cancer Center of Southeastern Ontario, Kingston, Ontario (Canada)

    2016-01-01

    Purpose: To evaluate the effect of a provincial practice guideline on the fractionation of palliative radiation therapy for bone metastases (PRT.B) in Ontario. Methods and Materials: The present retrospective study used electronic treatment records linked to Ontario's population-based cancer registry. Hierarchical multivariable regression analysis was used to evaluate temporal trends in the use of single fractions (SFs), controlling for patient-related factors associated with the use of SFs. Results: From 1984 to 2012, 43.9% of 161,835 courses of PRT.B were administered as SFs. The percentage of SF courses was greater for older patients (age <50 years, 39.8% vs age >80 years, 52.5%), those with a shorter life expectancy (survival >12 months, 36.9% vs < 1 month, 53.6%), and those who lived farther from a radiation therapy center (<10 km, 42.1% vs > 50 km, 47.3%). The percentage of SFs to spinal fields was lower than that to other skeletal sites (31.5% vs 57.1%). The percentage of SFs varied among the cancer centers (range, 26.0%-67.8%). These differences were all highly significant in the multivariable analysis (P<.0001). In 2004, Cancer Care Ontario released a practice guideline endorsing the use of SFs for uncomplicated bone metastases. The rate of use of SFs increased from 42.3% in the pre-guideline period (1999-2003) to 52.6% in the immediate post-guideline period (2004-2007). However, it subsequently decreased again to 44.0% (2009-2012). These temporal trends were significant after controlling for patient-related factors in the multivariable analysis (P<.0001). Large intercenter variations in the use of SFs persisted after publication of the guideline. Conclusions: The publication of an Ontario practice guideline endorsing the use of SF PRT.B was associated with only a transient increase in the use of SFs in Ontario and did little to reduce intercenter variations in fractionation.

  6. Immunosuppression Adherence in Stable Kidney Transplant Patients Converted From Immediate- to Prolonged-Release Tacrolimus in Clinical Practice: A Norwegian Study.

    Science.gov (United States)

    Abedini, Sadollah; Gøransson, Lasse; Cockburn, Elinor; Kilany, Suzanne; Holdaas, Hallvard

    2018-02-01

    This study investigated medication adherence in kidney transplant patients (KTPs) converted from immediate-release tacrolimus (IR-T) to prolonged-release tacrolimus (PR-T)-based immunosuppression in routine practice. Noninterventional, observational, multicenter study in Norway. Included adult KTPs with stable graft function, converted from IR-T (baseline) to PR-T (1 mg:1 mg) in routine practice. Data were collected at baseline, and months 1, 3, 6, and 12 postconversion. Primary endpoint: adherence using the Basel Assessment of Adherence to Immunosuppressive Medication Scale. Secondary assessments: tacrolimus dose and trough levels (target, 3-7 ng/mL), clinical laboratory parameters (eg, estimated glomerular filtration rate [Modified Diet in Renal Disease]), and adverse events. Ninety-one KTPs (mean ± SD age 47.7 ± 14.3 years) were analyzed. Mean ± SD change in PR-T dose from baseline (4.4 ± 2.4 mg/d) to month 12 was -0.1 ± 0.9 mg/d; mean tacrolimus trough levels remained within target. Overall medication adherence increased from 45.6% at baseline to 58.1% at month 1, but was similar to baseline thereafter; taking and timing adherence followed a similar pattern. Odds ratio (OR) for adherence at month 1 (but not at other time points) was greater versus baseline for overall (OR, 1.71; P = 0.0205), taking (OR, 3.38; P = 0.0004), and timing (OR, 1.77, P = 0.0252) dimensions. Mean ± SD Basel Assessment of Adherence to Immunosuppressive Medication Scale visual analogue scale score at baseline was 96.4 ± 5.5%, and increased postconversion. Estimated glomerular filtration rate remained stable (month 12, 61.6 ± 17.7 mL/min per 1.73 m 2 ), as did other laboratory parameters. Two (2.2%) patients had adverse events considered probably/possibly treatment-related. There was disparity between high, patient-perceived and low, actual adherence. Converting stable KTPs from IR-T to PR-T in routine practice did not impact long-term adherence to immunosuppression; renal

  7. Evaluation of an adjustable epidemiologic information system.

    Directory of Open Access Journals (Sweden)

    Jiunn-Shyan Julian Wu

    Full Text Available BACKGROUND: In order to facilitate public health response and to achieve early control of infectious disease epidemics, an adjustable epidemiologic information system (AEIS was established in the Taiwan public health network in February 2006. METHODOLOGY/PRINCIPAL FINDINGS: The performance of AEIS for the period 2006 through 2008 was evaluated based on a number of response times (RT and the public health impact. After implementation of the system, the apparent overall shortened RT was mainly due to the shortening of personnel response time (PRT and the time needed to draft a new questionnaire that incurred as personnel-system interface (PSI; PRT dropped from a fluctuating range of 9.8 ∼28.8 days in the first four months to <10 days in the following months and remained low till 2008 (0.88±1.52 days. The PSIs for newly emerged infectious diseases were 2.6 and 3.4 person-hours for H5N1 in 2007 and chikungunya in 2008, respectively, a much improvement from 1142.5 person-hours for SARS in 2003. The duration of each rubella epidemic cluster was evaluated as public health impact and showed a shortening trend (p = 0.019 that concurred with the shortening of PRT from 64.8±47.3 to 25.2±38.2 hours per cluster (p<0.0001. CONCLUSIONS/SIGNIFICANCE: The first evaluation of the novel instrument AEIS that had been used to assist Taiwan's multi-level government for infectious diseases control demonstrated that it was well integrated into the existing public health infrastructure. It provided flexible tools and computer algorithms with friendly interface for timely data collection, integration, and analysis; as a result, it shortened RTs, filled in gaps of personnel lacking sufficient experiences, created a more efficient flow of response, and identified asymptomatic/mild cases early to minimize further spreading. With further development, AEIS is anticipated to be useful in the application of other acute public health events needing immediate

  8. Evaluation of parasiticidal activity of fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate in horse foals with emphasis on ascarids (Parascaris equorum) in field studies on five farms in Central Kentucky in 2007.

    Science.gov (United States)

    Lyons, E T; Tolliver, S C; Ionita, M; Collins, S S

    2008-07-01

    Horse foals on five farms in Central Kentucky were used in field studies in 2007 evaluating activity of paste formulations of four compounds (fenbendazole-FBZ, ivermectin-IVM, oxibendazole-OBZ, and pyrantel pamoate-PRT) against internal parasites with emphasis on ascarids (Parascaris equorum). It has been well established the last few years that there is widespread resistance of P. equorum to ivermectin. The main purpose of the present research was to obtain current data on ascaridicidal activity of FBZ, OBZ, and PRT; also, to acquire further information on ascarid resistance to ivermectin. Additionally, data were documented on drug activity on small strongyles. Detection of ascarid and strongyle eggs in feces of foals was by a qualitative method (presence or absence) or a quantitative method (eggs per gram of feces). Strongyle eggs all were assumed to be from small strongyles. This is based on fecal cultures from horses on one farm and historic records from horses in this area on excellent deworming programs. A girth tape was used to estimate the body weight of each foal so that the appropriate dose rate of each drug could be given. Many of the foals were used in more than one cycle of treatments. Efficacy of the drugs, administered intraorally, was determined by calculating the average percentage reduction (% red.) of the number of foals passing eggs after vs. before treatment: (1) FBZ at 10 mg/kg was tested on four farms; 76 foals were examined, 50 with ascarid eggs (84% red.) and 62 with strongyle eggs (0% red.); (2) IVM at 200 microg/kg was tested on three farms; 58 foals were examined, 18 with ascarid eggs (0% red.) and 48 with strongyle eggs (100% red.); (3) OBZ at 10 mg/kg was tested on three farms; 181 foals were examined, 78 with ascarid eggs (94% red.) and 79 with strongyle eggs (0% red.); (4) PRT was tested on two farms, one farm at 1x (6.6 mg base/kg); 42 were foals examined, 16 with ascarid eggs (0% red.) and 33 with strongyle eggs (12% red.) and one

  9. Distinctive proteolytic activity of cell envelope proteinase of Lactobacillus helveticus isolated from airag, a traditional Mongolian fermented mare's milk.

    Science.gov (United States)

    Miyamoto, Mari; Ueno, Hiroshi M; Watanabe, Masayuki; Tatsuma, Yumi; Seto, Yasuyuki; Miyamoto, Taku; Nakajima, Hadjime

    2015-03-16

    Airag is a traditional fermented milk of Mongolia that is usually made from raw mare's milk. Lactobacillus helveticus is one of the lactic acid bacteria most frequently isolated from airag. In this study, we investigated the genetic and physiological characteristics of L. helveticus strains isolated from airag and clarified their significance in airag by comparing them with strains from different sources. Six strains of L. helveticus were isolated from five home-made airag samples collected from different regions of Mongolia. The optimal temperature for acidification in skim milk was 30 to 35°C for all the Mongolian strains, which is lower than those for the reference strains (JCM 1554 and JCM 1120(T)) isolated from European cheeses. All of the strains had a prtH1-like gene encoding a variant type of cell envelope proteinase (CEP). The CEP amino acid sequence in Snow Brand Typeculture (SBT) 11087 isolated from airag shared 71% identity with PrtH of L. helveticus CNRZ32 (AAD50643.1) but 98% identity with PrtH of Lactobacillus kefiranofaciens ZW3 (AEG40278.1) isolated from a traditional fermented milk in Tibet. The proteolytic activities of the CEP from SBT11087 on artificial substrate (N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide) and pure casein were measured using an intact-cell degradation assay. The activity of the CEP from SBT11087 was observed to be weak and exhibited a lower optimal temperature (40°C) than those from the reference strains (45-50°C). The specificity of the SBT11087 CEP for αS1-casein was typical of the CEPs previously reported in L. helveticus, as determined through the degradation profiles obtained through gel electrophoresis and mass spectrometry analyses. In contrast, the degradation profile of β-casein revealed that the CEP of SBT11087 primarily hydrolyzes its C-terminal domain and hydrolyzed nine of the 16 cleavage sites shared among the CEPs of other L. helveticus strains. Thus, the CEP of SBT11087 is distinct from those from

  10. Optical properties and light irradiance of monolithic zirconia at variable thicknesses.

    Science.gov (United States)

    Sulaiman, Taiseer A; Abdulmajeed, Aous A; Donovan, Terrence E; Ritter, André V; Vallittu, Pekka K; Närhi, Timo O; Lassila, Lippo V

    2015-10-01

    The aims of this study were to: (1) estimate the effect of polishing on the surface gloss of monolithic zirconia, (2) measure and compare the translucency of monolithic zirconia at variable thicknesses, and (3) determine the effect of zirconia thickness on irradiance and total irradiant energy. Four monolithic partially stabilized zirconia (PSZ) brands; Prettau® (PRT, Zirkonzahn), Bruxzir® (BRX, Glidewell), Zenostar® (ZEN, Wieland), Katana® (KAT, Noritake), and one fully stabilized zirconia (FSZ); Prettau Anterior® (PRTA, Zirkonzahn) were used to fabricate specimens (n=5/subgroup) with different thicknesses (0.5, 0.7, 1.0, 1.2, 1.5, and 2.0mm). Zirconia core material ICE® Zircon (ICE, Zirkonzahn) was used as a control. Surface gloss and translucency were evaluated using a reflection spectrophotometer. Irradiance and total irradiant energy transmitted through each specimen was quantified using MARC® Resin Calibrator. All specimens were then subjected to a standardized polishing method and the surface gloss, translucency, irradiance, and total irradiant energy measurements were repeated. Statistical analysis was performed using two-way ANOVA and post-hoc Tukey's tests (pgloss was significantly affected by polishing (p<0.05), regardless of brand and thickness. Translucency values ranged from 5.65 to 20.40 before polishing and 5.10 to 19.95 after polishing. The ranking from least to highest translucent (after polish) was: BRX=ICE=PRTPRT

  11. Agenda for action on air and health

    Energy Technology Data Exchange (ETDEWEB)

    Yaffe, B.; Perrotta, K.; Campbell, M.; Li-Muller, A.; Macfarlane, R.; Gingrich, S. [Toronto Public Health, ON (Canada)

    2004-07-01

    Toronto's acting medical officer of health estimates that five common air pollutants contribute to thousands of premature deaths and even more hospital admissions in Toronto every year. This report includes information from studies around the world which show that air pollution causes reduced lung function, asthma attacks, emergency room visits, lung cancer, high blood pressure and reduced life expectancy. The medical officer of health calls for action on air quality. The transportation sector was identified as the most significant source of air pollutants within the city, followed by the industrial sector and fuel consumption for power generation and home heating. Air quality in Toronto is also affected by coal-fired power plants that are upwind in southwestern Ontario and mid-western United States. This report was divided into 4 priority areas: (1) reduce use of, and emissions from, the transportation sector by increasing ridership on public transit and curbing urban sprawl, (2) reducing emissions from fuel consumption for home heating and power generation by phasing out coal-fired power plants and promoting energy efficiency, (3) reducing emissions from point sources that contribute to local and regional air quality concerns, and (4) improving the support systems needed to promote air quality improvements. Some of the recommendations were to develop a regional air quality plan that mandates significant reductions in smog-forming precursors from the industrial sector. 95 refs., 6 tabs., 1 fig., 2 appendices.

  12. Modeling of passengers' safety perception for buses on mountainous roads.

    Science.gov (United States)

    Khoo, Hooi Ling; Ahmed, Muaid

    2018-04-01

    This study had developed a passenger safety perception model specifically for buses taking into consideration the various factors, namely driver characteristics, environmental conditions, and bus characteristics using Bayesian Network. The behaviour of bus driver is observed through the bus motion profile, measured in longitudinal, lateral, and vertical accelerations. The road geometry is recorded using GPS and is computed with the aid of the Google map while the perceived bus safety is rated by the passengers in the bus in real time. A total of 13 variables were derived and used in the model development. The developed Bayesian Network model shows that the type of bus and the experience of the driver on the investigated route could have an influence on passenger's perception of their safety on buses. Road geometry is an indirect influencing factor through the driver's behavior. The findings of this model are useful for the authorities to structure an effective strategy to improve the level of perceived bus safety. A high level of bus safety will definitely boost passenger usage confidence which will subsequently increase ridership. Copyright © 2018 Elsevier Ltd. All rights reserved.

  13. Long-term User and Community Impacts of High-speed Rail in the United States’ Midwest Corridor

    Directory of Open Access Journals (Sweden)

    Jeffrey C. Peters

    2014-09-01

    Full Text Available This study contributes new insights in the debate over the viability of high-speed rail (HSR in the United States and the value proposition for government investment. The modeling focus of this study is two-fold, and the modeling approach makes a case for a fundamental shift from the current perspective of HSR viability. First, the user and community impact assessment of HSR is conducted in the same manner as traditional transportation system evaluation (i.e., vehicle operating costs (VOC, travel time, safety, emissions, and energy consumption to provide comparable conclusions regarding intercity transportation alternatives. Second, the model presented in this study analyzes both ridership and impacts within the same systematic framework to assess the long-term impacts on the individual transportation modes, total system metrics, and efficacy of alternate policies. Using this model, decision-makers can introduce various externalities to determine both the ideal and problematic conditions for the viability of a new HSR system.

  14. Transit's leading edge : innovations in service and technology : issue paper 7

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-11-01

    The Canadian Urban Transit Association is committed to raising awareness of the social, environmental and economic benefits of mass transit systems. Innovation is needed to address the challenges of attracting new riders, resolving fiscal imbalances, and meeting environmental concerns. This issue paper presents examples of how Canada's transit industry has used innovation to address the issue of climate change and fight smog. It includes a brief description of some of the ways that Canadian transit suppliers and transit systems are going green: Canada's bus builders are developing hybrid buses; Grand River Transit is improving air quality with clean diesel; Montreal's Transit Society is reducing emissions with biodiesel buses; Saskatoon Transit Service is using biodiesel buses; Laval's Transit Society is listening to customer complaints in an effort to reduce response times and improve customer service; Canadian Urban Transit Association is improving customer service; Transit Windsor is promoting a smog solution; Winnipeg Transit is working with employers to boost ridership; Trapeze Software Group is providing customers with quick and accurate trip itineraries; St. John's Transportation Commission has added solar-powered, light emitting diode illumination to bus stops; the City of Ottawa has an established transit priority measures; and, Infodev EDI Inc. has supplied automated high-technology solutions for passenger counting and vehicle location tracking to several Canadian transit systems. refs., figs.

  15. Bias of averages in life-cycle footprinting of infrastructure: truck and bus case studies.

    Science.gov (United States)

    Taptich, Michael N; Horvath, Arpad

    2014-11-18

    The life-cycle output (e.g., level of service) of infrastructure systems heavily influences their normalized environmental footprint. Many studies and tools calculate emission factors based on average productivity; however, the performance of these systems varies over time and space. We evaluate the appropriate use of emission factors based on average levels of service by comparing them to those reflecting a distribution of system outputs. For the provision of truck and bus services where fuel economy is assumed constant over levels of service, emission factor estimation biases, described by Jensen's inequality, always result in larger-than-expected environmental impacts (3%-400%) and depend strongly on the variability and skew of truck payloads and bus ridership. Well-to-wheel greenhouse gas emission factors for diesel trucks in California range from 87 to 1,500 g of CO2 equivalents per ton-km, depending on the size and type of trucks and the services performed. Along a bus route in San Francisco, well-to-wheel emission factors ranged between 53 and 940 g of CO2 equivalents per passenger-km. The use of biased emission factors can have profound effects on various policy decisions. If average emission rates must be used, reflecting a distribution of productivity can reduce emission factor biases.

  16. Analyzing the United States Department of Transportation's Implementation Strategy for High Speed Rail: Three Case Studies

    Science.gov (United States)

    Robinson, Ryan

    High-speed rail (HSR) has become a major contributor to the transportation sector with a strong push by the Obama Administration and the Department of Transportation to implement high-speed rail in the United States. High-speed rail is a costly transportation alternative that has the potential displace some car and airport travel while increase energy security and environmental sustainability. This thesis will examine the United States high-speed rail implementation strategy by comparing it to the implementation strategies of France, Japan, and Germany in a multiple case study under four main criteria of success: economic profitability, reliability, safety, and ridership. Analysis will conclude with lessons to be taken away from the case studies and applied to the United States strategy. It is important to understand that this project has not been established to create a comprehensive implementation plan for high-speed rail in the United States; rather, this project is intended to observe the depth and quality of the current United States implementation strategy and make additional recommendations by comparing it with France, Japan, and Germany.

  17. An Assessment of Future Demands for and Benefits of Public Transit Srevices in Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    Southworth, F.

    2004-04-29

    This report documents results from a study carried out by Oak Ridge National Laboratory and the University of Tennessee at Knoxville for the Office of Public Transportation, Tennessee Department of Transportation. The study team was tasked with developing a process and a supporting methodology for estimating the benefits accruing to the State from the operation of state supported public transit services. The team was also tasked with developing forecasts of the future demands for these State supported transit services at five year intervals through the year 2020, broken down where possible to the local transit system level. Separate ridership benefits and forecasts were also requested for the State's urban and rural transit operations. Tennessee's public transit systems are subsidized to a degree by taxpayers. It is therefore in the public interest that assessments of the benefits of such systems be carried out at intervals, to determine how they are contributing to the well-being of the state's population. For some population groups within the State of Tennessee these transit services have become essential as a means of gaining access to workplaces and job training centers, to educational and health care facilities, as well as to shops, social functions and recreational sites.

  18. An Assessment of Future Demands for and Benefits of Public Transit Services in Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    Southworth, F.

    2003-06-10

    This report documents results from a study carried out by Oak Ridge National Laboratory and the University of Tennessee at Knoxville for the Office of Public Transportation, Tennessee Department of Transportation. The study team was tasked with developing a process and a supporting methodology for estimating the benefits accruing to the State from the operation of state supported public transit services. The team was also tasked with developing forecasts of the future demands for these State supported transit services at five year intervals through the year 2020, broken down where possible to the local transit system level. Separate ridership benefits and forecasts were also requested for the State's urban and rural transit operations. Tennessee's public transit systems are subsidized to a degree by taxpayers. It is therefore in the public interest that assessments of the benefits of such systems be carried out at intervals, to determine how they are contributing to the well-being of the state's population. For some population groups within the State of Tennessee these transit services have become essential as a means of gaining access to workplaces and job training centers, to educational and health care facilities, as well as to shops, social functions and recreational sites.

  19. Human mobility in space from three modes of public transportation

    Science.gov (United States)

    Jiang, Shixiong; Guan, Wei; Zhang, Wenyi; Chen, Xu; Yang, Liu

    2017-10-01

    The human mobility patterns have drew much attention from researchers for decades, considering about its importance for urban planning and traffic management. In this study, the taxi GPS trajectories, smart card transaction data of subway and bus from Beijing are utilized to model human mobility in space. The original datasets are cleaned and processed to attain the displacement of each trip according to the origin and destination locations. Then, the Akaike information criterion is adopted to screen out the best fitting distribution for each mode from candidate ones. The results indicate that displacements of taxi trips follow the exponential distribution. Besides, the exponential distribution also fits displacements of bus trips well. However, their exponents are significantly different. Displacements of subway trips show great specialties and can be well fitted by the gamma distribution. It is obvious that human mobility of each mode is different. To explore the overall human mobility, the three datasets are mixed up to form a fusion dataset according to the annual ridership proportions. Finally, the fusion displacements follow the power-law distribution with an exponential cutoff. It is innovative to combine different transportation modes to model human mobility in the city.

  20. Global bike share: What the data tells us about road safety.

    Science.gov (United States)

    Fishman, Elliot; Schepers, Paul

    2016-02-01

    Bike share has emerged as a rapidly growing mode of transport in over 800 cities globally, up from just a handful in the 1990s. Some analysts had forecast a rise in the number of bicycle crashes after the introduction of bike share, but empirical research on bike share safety is rare. The goal of this study is to examine the impact of bike share programs on cycling safety. The paper has two substudies. Study 1 was a secondary analysis of longitudinal hospital injury data from the Graves et al. (2014) study. It compared cycling safety in cities that introduced bike share programs with cities that did not. Study 2 combined ridership data with crash data of selected North American and European cities to compare bike share users to other cyclists. Study 1 indicated that the introduction of a bike share system was associated with a reduction in cycling injury risk. Study 2 found that bike share users were less likely than other cyclists to sustain fatal or severe injuries. On a per kilometer basis, bike share is associated with decreased risk of both fatal and non-fatal bicycle crashes when compared to private bike riding. The results of this study suggest that concerns of decreased levels of cycling safety are unjustified and should not prevent decision makers from introducing public bike share schemes, especially if combined with other safety measures like traffic calming. Copyright © 2015 Elsevier Ltd and National Safety Council. All rights reserved.

  1. Season-ahead streamflow forecast informed tax strategies for semi-arid water rights markets

    Science.gov (United States)

    Delorit, J. D.; Block, P. J.

    2016-12-01

    In many semi-arid regions multisectoral demands stress available water supplies. The Elqui River valley of north central Chile, which draws on limited capacity reservoirs supplied largely by annually variable snowmelt, is one of these cases. This variability forces water managers to develop demand-based allocation strategies which have typically resulted in water right volume reductions, applied equally per right. Compounding this issue is often deferred or delayed infrastructure investments, which has been linked Chile's Coasian approach to water markets, under which rights holders do not pay direct procurement costs, non-use fees, nor taxes. Here we build upon our previous research using forecasts of likely water rights reductions, informed by season-ahead prediction models of October-January (austral growing season) streamflow, to construct annual, forecast-sensitive, per right tax. We believe this tax, to be borne by right holders, will improve the beneficial use of water resources by stimulating water rights trading and improving system efficiency by generating funds for infrastructure investment, thereby reducing free-ridership and conflict between rights holders. Research outputs will include sectoral per right tax assessments, tax revenue generation, Elqui River valley economic output, and water rights trading activity.

  2. The role of subway travel in an influenza epidemic: a New York City simulation.

    Science.gov (United States)

    Cooley, Philip; Brown, Shawn; Cajka, James; Chasteen, Bernadette; Ganapathi, Laxminarayana; Grefenstette, John; Hollingsworth, Craig R; Lee, Bruce Y; Levine, Burton; Wheaton, William D; Wagener, Diane K

    2011-10-01

    The interactions of people using public transportation in large metropolitan areas may help spread an influenza epidemic. An agent-based model computer simulation of New York City's (NYC's) five boroughs was developed that incorporated subway ridership into a Susceptible-Exposed-Infected-Recovered disease model framework. The model contains a total of 7,847,465 virtual people. Each person resides in one of the five boroughs of NYC and has a set of socio-demographic characteristics and daily behaviors that include age, sex, employment status, income, occupation, and household location and membership. The model simulates the interactions of subway riders with their workplaces, schools, households, and community activities. It was calibrated using historical data from the 1957-1958 influenza pandemics and from NYC travel surveys. The surveys were necessary to enable inclusion of subway riders into the model. The model results estimate that if influenza did occur in NYC with the characteristics of the 1957-1958 pandemic, 4% of transmissions would occur on the subway. This suggests that interventions targeted at subway riders would be relatively ineffective in containing the epidemic. A number of hypothetical examples demonstrate this feature. This information could prove useful to public health officials planning responses to epidemics.

  3. Future Parking Demand at Rail Stations in Klang Valley

    Directory of Open Access Journals (Sweden)

    Ho Phooi Wai

    2017-01-01

    Full Text Available Klang Valley, Malaysia is currently undergoing a massive development of rail transportation system expansion where the current integrated rail transit system will see new extensions of two MRT lines and an LRT line by year 2020. By year 2017, the first MRT line will be ready to run with 31 new rail stations connected to the current passenger rail network. The existing Park and Ride facilities in Klang Valley are commonly known as being unable to sufficiently cater for the current parking space demand. Therefore, with the expansion of many additional rail stations which are rapidly under construction, there are doubts that the future parking space at rail stations will be able to accommodate the sudden rise of rail passengers. Although the authorities are increasing parking bays at various locations, will the future parking demand at rail stations be sufficient? This paper studies the factors influencing parking demand in terms of population, car ownership, new car registrations and passenger rail ridership and estimating the future parking demand using Linear Regression method. Result shows that the forecasted parking demand at rail stations after the implementation of the first new MRT system in 2017 is 2.7 times more than in 2014.

  4. Exploring the safety in numbers effect for vulnerable road users on a macroscopic scale.

    Science.gov (United States)

    Tasic, Ivana; Elvik, Rune; Brewer, Simon

    2017-12-01

    A "Safety in Numbers" effect for a certain group of road users is present if the number of crashes increases at a lower rate than the number of road users. The existence of this effect has been invoked to justify investments in multimodal transportation improvements in order to create more sustainable urban transportation systems by encouraging walking, biking, and transit ridership. The goal of this paper is to explore safety in numbers effect for cyclists and pedestrians in areas with different levels of access to multimodal infrastructure. Data from Chicago served to estimate the expected number of crashes on the census tract level by applying Generalized Additive Models (GAM) to capture spatial dependence in crash data. Measures of trip generation, multimodal infrastructure, network connectivity and completeness, and accessibility were used to model travel exposure in terms of activity, number of trips, trip length, travel opportunities, and conflicts. The results show that a safety in numbers effect exists on a macroscopic level for motor vehicles, pedestrians, and bicyclists. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. A STUDY ON THE INTRODUCTION OF BUS RAPID TRANSIT SYSTEM IN ASIAN DEVELOPING CITIES

    Directory of Open Access Journals (Sweden)

    Thaned SATIENNAM

    2006-01-01

    Full Text Available Bus Rapid Transit (BRT has increasingly become an attractive urban transit alternative in many Asian developing cities due to its cost-effective and flexible implementation. However, it still seems to be difficult to introduce BRT to these cities because almost all of their city structures have been developed under solely a road transport development city plan and weakness of land use control gives rise to many problems, such as urban sprawl, traffic congestion, and air pollution. The purpose of this study was to introduce several strategies to support BRT implementation in Asian developing cities, such as a strategy to appropriately integrate the paratransit system into BRT system as being a feeder along a BRT corridor to supply demand. These proposed strategies were evaluated by applying demand forecasting and emission models to the BRT project plan of Bangkok Metropolitan Administration (BMA in Thailand. It was demonstrated that the proposed strategies could effectively improve the BRT ridership, traffic conditions, and air pollution emission of the entire system in Bangkok. This study could be further extended to include strategy recommendation if a BRT system were to be introduced to other Asian developing cities.

  6. Saturday Driving Restrictions Fail to Improve Air Quality in Mexico City

    Science.gov (United States)

    Davis, Lucas W.

    2017-02-01

    Policymakers around the world are turning to license-plate based driving restrictions in an effort to address urban air pollution. The format differs across cities, but most programs restrict driving once or twice a week during weekdays. This paper focuses on Mexico City, home to one of the oldest and best-known driving restriction policies. For almost two decades Mexico City’s driving restrictions applied during weekdays only. This changed recently, however, when the program was expanded to include Saturdays. This paper uses hourly data from pollution monitoring stations to measure the effect of the Saturday expansion on air quality. Overall, there is little evidence that the program expansion improved air quality. Across eight major pollutants, the program expansion had virtually no discernible effect on pollution levels. These disappointing results stand in sharp contrast to estimates made before the expansion which predicted a 15%+ decrease in vehicle emissions on Saturdays. To understand why the program has been less effective than expected, the paper then turns to evidence from subway, bus, and light rail ridership, finding no evidence that the expansion was successful in getting drivers to switch to lower-emitting forms of transportation.

  7. High-speed rail with emerging automobiles and aircraft can reduce environmental impacts in California’s future

    International Nuclear Information System (INIS)

    Chester, Mikhail; Horvath, Arpad

    2012-01-01

    Sustainable mobility policy for long-distance transportation services should consider emerging automobiles and aircraft as well as infrastructure and supply chain life-cycle effects in the assessment of new high-speed rail systems. Using the California corridor, future automobiles, high-speed rail and aircraft long-distance travel are evaluated, considering emerging fuel-efficient vehicles, new train designs and the possibility that the region will meet renewable electricity goals. An attributional per passenger-kilometer-traveled life-cycle inventory is first developed including vehicle, infrastructure and energy production components. A consequential life-cycle impact assessment is then established to evaluate existing infrastructure expansion against the construction of a new high-speed rail system. The results show that when using the life-cycle assessment framework, greenhouse gas footprints increase significantly and human health and environmental damage potentials may be dominated by indirect and supply chain components. The environmental payback is most sensitive to the number of automobile trips shifted to high-speed rail, and for greenhouse gases is likely to occur in 20–30 years. A high-speed rail system that is deployed with state-of-the-art trains, electricity that has met renewable goals, and in a configuration that endorses high ridership will provide significant environmental benefits over existing modes. Opportunities exist for reducing the long-distance transportation footprint by incentivizing large automobile trip shifts, meeting clean electricity goals and reducing material production effects. (letter)

  8. Evaluating the impacts of the clean cities program.

    Science.gov (United States)

    Qiu, Shiyong; Kaza, Nikhil

    2017-02-01

    The Department of Energy's Clean Cities program was created in 1993 to reduce petroleum usage in the transportation sector. The program promotes alternative fuels such as biofuels and fuel-saving strategies such as idle reduction and fleet management through coalitions of local government, non-profit, and private actors. Few studies have evaluated the impact of the program because of its complexity that include interrelated strategies of grants, education and training and diversity of participants. This paper uses a Difference-in-Differences (DiD) approach to evaluate the effectiveness of the program between 1990 and 2010. We quantify the effectiveness of the Clean Cities program by focusing on performance measures such as air quality, number of alternative fueling stations, private vehicle occupancy and transit ridership. We find that counties that participate in the program perform better on all these measures compared to counties that did not participate. Compared to the control group, counties in the Clean Cities program experienced a reduction in days with bad air quality (3.7%), a decrease in automobile commuters (2.9%), an overall increase in transit commuters (2.1%) and had greater numbers of new alternative fueling stations (12.9). The results suggest that the program is a qualified success. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. Performance Analysis of Trans-Jakarta Bus Suburban Service Move-Across Greater Jakarta

    Science.gov (United States)

    Tangkudung, ESW; Widyadayinta, C.

    2018-03-01

    Trans-Jakarta have developed their services scope as Suburban Service or Feeder move-across service that operate from greater Jakarta into Jakarta central vice versa. One of the route is Ciputat – Bundaran Hotel Indonesia (Tosari) and integrated with corridor 1 (one) and 8 (eight). This service is not travel on the exclusive lane or bus-way. Objective of Government Jakarta to provide this service is to decrease private car to enter the central of Jakarta. The objective of this study is to find the performance of the service. Survey have conducted static and dynamic on work day to get variable of travel time and delay, waiting time of passenger at the bus stop, headway and ridership of the bus. Service Standard Minimum of Trans-Jakarta have compared with the result of variable headway, travel speed, and waiting time at bus stop as concern of all the passengers. Analysis use correlation test method and linear regression model have done. The performance of Trans-Jakarta bus suburban service, based on travel speed indicator is fairly bad, only 8.1% of trip could comply with Minimum Service Standard. Bus performance based on the indicator of density in the bus is good, where all points are below the maximum limit i.e. 8 people/m2 at peak hour and 5 people/m2 at off-peak hour.

  10. Proceedings of the first users meeting for the Advanced Photon Source

    Energy Technology Data Exchange (ETDEWEB)

    1988-02-01

    The first national users meeting for the Advanced Photon Source (APS) at Argonne National Laboratory - held November 13-14, 1986, at Argonne - brought together scientists and engineers from industry, universities, and national laboratories to exchange information on the design of the facility and expectations for its use. Presented papers and potential participating research team (PRT) plans are documented in these proceedings. Topics covered include the current status of the project, an overview of the APS conceptual design, scientific opportunities offered by the facility for synchrotron-radiation-related research, current proposals and funding mechanisms for beam lines, and user policies. A number of participants representing universities and private industry discussed plans for the possible formation of PRTs to build and use beam lines at the APS site. The meeting also provided an opportunity for potential users to organize their efforts to support and guide the facility's development.

  11. Proceedings of the first users meeting for the Advanced Photon Source

    International Nuclear Information System (INIS)

    1988-02-01

    The first national users meeting for the Advanced Photon Source (APS) at Argonne National Laboratory - held November 13-14, 1986, at Argonne - brought together scientists and engineers from industry, universities, and national laboratories to exchange information on the design of the facility and expectations for its use. Presented papers and potential participating research team (PRT) plans are documented in these proceedings. Topics covered include the current status of the project, an overview of the APS conceptual design, scientific opportunities offered by the facility for synchrotron-radiation-related research, current proposals and funding mechanisms for beam lines, and user policies. A number of participants representing universities and private industry discussed plans for the possible formation of PRTs to build and use beam lines at the APS site. The meeting also provided an opportunity for potential users to organize their efforts to support and guide the facility's development

  12. The Beam Line X NdFe-steel hybrid wiggler for SSRL

    International Nuclear Information System (INIS)

    Hoyer, E.; Halbach, K.; Humphries, D.; Marks, S.; Plate, D.; Shuman, D.; Karpenko, V.P.; Kulkarni, S.; Tirsell, K.G.

    1987-01-01

    A wiggler magnet with 15 periods, each 12.85 cm long, which achieves 1.40 T at a 2.1 cm gap (2.26T at 0.8 cm) has been designed and is now in fabrication at LBL. This wiggler will be the radiation source of the high intensity synchrotron radiation beam line for the Beam Line X PRT facility at SSRL. The magnet utilizes Neodymium-Iron (NdFe) material and Vanadium Permendur (steel) in the hybrid configuration to achieve simultaneously a high magnetic field and short period. Magnetic field adjustment is with a driven chain and ball screw drive system. The magnetic structure is external to an s.s. vacuum chamber which has thin walls, 0.76 mm thickness, at each pole tip for higher field operation. Magnetic design, construction details and magnetic measurements are presented

  13. Progressive resistance training in head and neck cancer patients during concomitant chemoradiotherapy -- design of the DAHANCA 31 randomized trial

    DEFF Research Database (Denmark)

    Lonkvist, Camilla K; Lønbro, Simon; Vinther, Anders

    2017-01-01

    . This randomized study investigates whether progressive resistance training (PRT) may attenuate loss of muscle mass and functional performance. Furthermore, biochemical markers and muscle biopsies will be investigated trying to link biological mechanisms to training effects. METHODS: At the Departments of Oncology...... content in muscles, as well as muscle fiber type and fiber size in muscle biopsies. Muscle biopsies are optional. DISCUSSION: This randomized study investigates the impact of a 12-week progressive resistance training program on lean body mass and several other physiological endpoints, as well as impact...... on adverse events and quality of life. Furthermore, a translational approach is integrated with extensive biological sampling and exploration into cytokines and mechanisms involved. The current paper discusses decisions and methods behind exercise in head and neck cancer patients undergoing concomitant...

  14. PepJ is a new extracellular proteinase of Aspergillus nidulans.

    Science.gov (United States)

    Emri, T; Szilágyi, M; László, K; M-Hamvas, M; Pócsi, I

    2009-01-01

    Under carbon starvation, Aspergillus nidulans released a metallo-proteinase with activities comparable to those of PrtA, the major extracellular serine proteinase of the fungus. The relative molar mass of the enzyme was 19 kDa as determined with both denaturing and renaturing SDS PAGE, while its isoelectric point and pH and temperature optima were 8.6, 5.5 and 65 degrees C, respectively. The enzyme was stable at pH 3.5-10.5 and was still active at 95 degrees C in the presence of azocasein substrate. MALDI-TOF MS analysis demonstrated that the proteinase was encoded by the pepJ gene (locus ID AN7962.3), and showed high similarity to deuterolysin from Aspergillus oryzae. The size of the mature enzyme, its EDTA sensitivity and heat stability also supported the view that A. nidulans PepJ is a deuterolysin-type metallo-proteinase.

  15. Two-stage multipolar ordering in Pr T2Al20 Kondo materials

    Science.gov (United States)

    Freyer, Frederic; Attig, Jan; Lee, SungBin; Paramekanti, Arun; Trebst, Simon; Kim, Yong Baek

    2018-03-01

    Among heavy fermion materials, there is a set of rare-earth intermetallics with non-Kramers Pr3 +4 f2 moments which exhibit a rich phase diagram with intertwined quadrupolar orders, superconductivity, and non-Fermi liquid behavior. However, more subtle broken symmetries such as multipolar orders in these Kondo materials remain poorly studied. Here, we argue that multi-spin interactions between local moments beyond the conventional two-spin exchange must play an important role in Kondo materials near the ordered to heavy Fermi liquid transition. We show that this drives a plethora of phases with coexisting multipolar orders and multiple thermal phase transitions, providing a natural framework for interpreting experiments on the Pr(T) 2Al20 class of compounds.

  16. Regulatory processes in Aspergillus niger

    DEFF Research Database (Denmark)

    Poulsen, Lars

    characteristics, as a lower oxalic ii acid formation and wild type growth performance; it was therefore argued that this strain could be an attractive alternative to ΔprtT. Finally, in order to characterize the formation of the carcinogenic mycotoxin fumonisin, a reporter strain of A. niger was constructed, where...... the promoter from the fumonisin synthase was fused to the green fluorescent protein. This strain was used together with the commercial large-scale nutrient profiling platform, Biolog Phenotype MicroArrays. Out of the 476 conditions tested, six compounds significantly induce fumonisin production, identified....... These formed the basis for the subsequent examinations, which resulted in the identification of azelaic acid, a plant hormone and a very potent fumonisin inducer....

  17. Self-diffusion in periodic porous media: a comparison of numerical simulation and eigenvalue methods.

    Science.gov (United States)

    Schwartz, L M; Bergman, D J; Dunn, K J; Mitra, P P

    1996-01-01

    Random walk computer simulations are an important tool in understanding magnetic resonance measurements in porous media. In this paper we focus on the description of pulsed field gradient spin echo (PGSE) experiments that measure the probability, P(R,t), that a diffusing water molecule will travel a distance R in a time t. Because PGSE simulations are often limited by statistical considerations, we will see that valuable insight can be gained by working with simple periodic geometries and comparing simulation data to the results of exact eigenvalue expansions. In this connection, our attention will be focused on (1) the wavevector, k, and time dependent magnetization, M(k, t); and (2) the normalized probability, Ps(delta R, t), that a diffusing particle will return to within delta R of the origin after time t.

  18. Mechanical Devices Readiness FY04.0402.1

    Energy Technology Data Exchange (ETDEWEB)

    Bender, Thomas R.

    2008-10-10

    This Advanced Design and Production Technologies (ADAPT) project funded production process and tooling improvements to meet and sustain rate production for the program mechanism assemblies. Techniques were developed to allow evaluation and rework of sealed mechanisms that will result in prevention of the scrapping of future mechanisms. Future system mechanisms will likely be smaller with tighter tolerance parts that will require improved inspection equipment and techniques. During the latter phase of this project, the ISL (Intent Stronglink) PRT (Product Realization Team) developed designs and manufacturing processes at Sandia and at multiple KCP (Kansas City Plant) vendors, to produce glass ceramic headers to replace the brazed ceramic headers in the ISL. This achievement will result in significant production costs savings (unit cost and product scrap due to leaking headers).

  19. The Impact of Locus of Control and Controlling Language on Psychological Reactance and Ad Effectiveness in Health Communication.

    Science.gov (United States)

    Xu, Jie

    2017-12-01

    Based on two theoretical models-psychological reactance theory (PRT) and locus of control-this study examines the individual and joint effects of locus of control and controlling language on young adults' information processing. Two experimental studies on anti-driving-after-drinking (anti-DAD) and antismoking public service announcements (PSAs) were conducted that were conceptual replications of each other. Both studies afforded evidence that those with external locus of control were more involved in risky behaviors. There was a consistent interaction between locus of control and controlling language, such that those with internal locus of control were more sensitive to this message feature compared to those with external locus of control. Controlling language was found to increase reactance. The theoretical and managerial implications for health communication are elaborated. Limitations and directions for future research are also outlined.

  20. Large-q correlations from a Hubble-type pion source

    International Nuclear Information System (INIS)

    Barghouty, A.F.; Miller, J.; Frankel, K.A.

    1993-01-01

    In two-pion correlation measurements from relativistic nuclear collisions, the correlation function, C 2 (q), appears to exhibit an oscillatory structure at large (q ≥100 MeV/c) relative momentum. If real, this structure may have consequences for the determination of the space-time extent of the pion source. A qualitatively similar feature is seen in cellular automaton simulations of a Lorentz gas. It has been argued phenomenologically that the q-dependent oscillations can arise from an interplay between successive scattering probabilities and density variations of an exploding pion source. To further illustrate this interplay we consider a Hubble-type free expansion model for the source in which the density is time-folded from an initial Gaussian. This allows the source expansion to enter as a dynamical variable in the source density p[r(t); t] and thus C 2 , along with any signature of the interplay between scattering and source density