WorldWideScience

Sample records for proximal diminutive adr

  1. Administrative Data Repository (ADR)

    Data.gov (United States)

    Department of Veterans Affairs — The Administrative Data Repository (ADR) was established to provide support for the administrative data elements relative to multiple categories of a person entity...

  2. Breakup of diminutive Rayleigh jets

    NARCIS (Netherlands)

    van Hoeve, W.; Gekle, S.; Snoeijer, Jacobus Hendrikus; Versluis, Michel; Brenner, Michael P.; Lohse, Detlef

    2010-01-01

    Discharging a liquid from a nozzle at sufficient large velocity leads to a continuous jet that due to capillary forces breaks up into droplets. Here we investigate the formation of microdroplets from the breakup of micron-sized jets with ultra high-speed imaging. The diminutive size of the jet

  3. Market segmentation: Venezuelan ADRs

    Directory of Open Access Journals (Sweden)

    Urbi Garay

    2012-12-01

    Full Text Available The control on foreign exchange imposed by Venezuela in 2003 constitute a natural experiment that allows researchers to observe the effects of exchange controls on stock market segmentation. This paper provides empirical evidence that although the Venezuelan capital market as a whole was highly segmented before the controls were imposed, the shares in the firm CANTV were, through their American Depositary Receipts (ADRs, partially integrated with the global market. Following the imposition of the exchange controls this integration was lost. Research also documents the spectacular and apparently contradictory rise experienced by the Caracas Stock Exchange during the serious economic crisis of 2003. It is argued that, as it happened in Argentina in 2002, the rise in share prices occurred because the depreciation of the Bolívar in the parallel currency market increased the local price of the stocks that had associated ADRs, which were negotiated in dollars.

  4. Colombian ADRs: Why so few?

    Directory of Open Access Journals (Sweden)

    Maximiliano González

    2011-12-01

    Full Text Available We address the question of why Colombian companies have had such a limited presence in the American Depositary Receipts (ADRs market. Traditional explanations state that weak investor protection and the degree of economic and financial development in Colombia increase the cost of entry in the ADR market. However, in the case of Colombia these explanations do not suffice because in these respects Colombia is no different from other Latin American countries. Using a theoretical model, we show that additional factors such as drug trafficking and armed conflict better explain why Colombian firms have moved away from the ADRs market

  5. Shielded ADR Magnets For Space Applications Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Phase II program will concentrate on manufacturing of qualified low-current, light-weight, 10K ADR magnets for space application. Shielded ADR solenoidal magnets...

  6. Universal Tendencies in the Semantics of the Diminutive.

    Science.gov (United States)

    Jurafsky, Daniel

    1996-01-01

    Proposes to model the synchronic and diachronic semantics of the diminutive category with a "Radial Category," a type of structured polysemy that explicitly models the different senses of the diminutive and the metaphorical and inferential relations that bind them. The model is tested by considering the semantics of the diminutive in…

  7. Adræt Virksomhedsudvikling

    DEFF Research Database (Denmark)

    Mikkelsen, Hans; Riis, Jens Ove

    fra Industriens Realkredit Fond og Center for Industriel Produktion (CIP) har muliggjort gennemførelse af et projekt om Agile Project Portfolio Management, som har omfattet en sammenfattende og struktureret fremstilling af de to begreber og deres anvendelse inden for virksomhedsudvikling. Case...... principper og virkemidler, der ligger i begreberne Lean (slank) og Agile (adræt), rummer interessante perspektiver for også at kunne finde anvendelse inden for virksomhedsudvikling. En sammenstilling af de to begreber til Agilean udgør et forsøg på at uddrage det bedste fra de to begrebssæt. Økonomisk støtte...

  8. Adræt Virksomhedsudvikling

    DEFF Research Database (Denmark)

    Mikkelsen, Hans; Riis, Jens Ove

    principper og virkemidler, der ligger i begreberne Lean (slank) og Agile (adræt), rummer interessante perspektiver for også at kunne finde anvendelse inden for virksomhedsudvikling. En sammenstilling af de to begreber til Agilean udgør et forsøg på at uddrage det bedste fra de to begrebssæt. Økonomisk støtte...... fra Industriens Realkredit Fond og Center for Industriel Produktion (CIP) har muliggjort gennemførelse af et projekt om Agile Project Portfolio Management, som har omfattet en sammenfattende og struktureret fremstilling af de to begreber og deres anvendelse inden for virksomhedsudvikling. Case...

  9. Slovene Nominal Diminutives and their English Equivalents: A Comparison

    Directory of Open Access Journals (Sweden)

    Eva Sicherl

    2012-05-01

    Full Text Available A contrastive analysis of nominal diminutives in Slovene and English clearly shows that diminutive formation and use of diminutives in Slovene is tied to the morphological characteristics of nouns and, consequently, their morphological–lexemic features, whereas the focus of diminutive formation and use in English remains bound to the syntactic use, or rather, the respective syntactico–semantic use of a given lexeme. In all languages, diminutiveness is a basic meaning– forming element, which can, however, be realized predominantly morphologically, as is the case in Slovene, or predominantly syntactically, as is the case in English. As a meaning–forming element it also plays a crucial role in the development of terminology – in this case the diminutive as language metaphor gains semantic independence and becomes a technical term.

  10. The derivation of diminutives from abstract noun bases in Bulgarian

    Directory of Open Access Journals (Sweden)

    Nicolova Ruselina L.

    2013-01-01

    Full Text Available The paper reviews the formal and semantic characteristics of the formation of diminutives in Bulgarian, where the process affects nouns, adjectives, numerals, adverbs, verbs and pronouns. The derivation of diminutives from abstract nouns is analyzed on the basis of material excerpted from blogs and forums in the Bulgarian Google, in which significant activation of the process in the language practices of young speakers is observed. The factors which facilitate or constrain the derivation of diminutives from abstract nouns are studied, as well as the semantic interaction between diminutive suffixes and certain semantic components (both denotative and connotative of base words.

  11. Early postmenopausal diminution of forearm and spinal bone mineral density

    DEFF Research Database (Denmark)

    Bjarnason, K; Hassager, C; Ravn, Pernille

    1995-01-01

    ) and anteroposterior (AP) projections, and in the distal third of the forearm. The postmenopausal diminution of BMD was best described by an exponential fit. The initial rate of postmenopausal diminution of BMD was highest in the most trabecular sites (LAT > AP > forearm), but 10-year diminution was similar at all...... sites (12%-13%, corresponding to about 1.0-1.5 SD), and extrapolation suggested reverse order of the rates of diminution thereafter (forearm > AP > LAT). When bone mineral content of the entire L3 vertebra (tBMC) was measured in vivo, AP tBMC could account for only 67% of the variation in LAT t...

  12. Shielded ADR Magnets For Space Applications Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An important consideration of the use of superconducting magnets in ADR applications is shielding of the other instruments in the vicinity of the superconducting...

  13. Syntactic Variation in Diminutive Suffixes: Russian, Kolyma Yukaghir, and Itelmen

    Directory of Open Access Journals (Sweden)

    Olga Steriopolo

    2017-11-01

    Full Text Available This article presents a syntactic analysis and comparison of diminutive suffixes in Russian, Kolyma Yukaghir, and Itelmen, three genetically unrelated languages of the Russian Federation. Kolyma Yukaghir and Itelmen are on the verge of extinction. This article investigates how contact with Russian (specifically the syntax of Russian diminutives has influenced the syntax of diminutives in Kolyma Yukaghir and Itlemen. Adopting the framework of Distributed Morphology, a syntactic analysis of diminutives across the three languages reveals that they share the same manner of syntactic attachment, but differ in regards to the site or place of attachment. Specifically, it is proposed that diminutives in all three languages are syntactic modifiers; however, in relation to the place of attachment, in Russian, diminutives attach below the functional category of Number, while diminutives in Kolyma Yukaghir and Itelmen attach above the Number category. This article contributes to our understanding of variation in universal grammar and linguistic outcomes of the syntactic feature ‘diminutive’ in a multilingual situation where a majority language is in contact with two genetically unrelated endangered languages.

  14. 49 CFR 1109.3 - Confidentiality in ADR Matters

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Confidentiality in ADR Matters 1109.3 Section 1109... PROCEEDINGS AND THOSE IN WHICH THE BOARD IS A PARTY § 1109.3 Confidentiality in ADR Matters In all ADR matters involving the Board, whether under the Administrative Dispute Resolution Act or not, the confidentiality...

  15. Conditioned diminution of the unconditioned skin conductance response.

    Science.gov (United States)

    Knight, David C; Lewis, Eleanor P; Wood, Kimberly H

    2011-08-01

    During Pavlovian conditioning the expression of a conditioned response typically serves as evidence that an association between a conditioned stimulus (CS) and an unconditioned stimulus (UCS) has been learned. However, learning-related changes in the unconditioned response (UCR) produced by a predictable UCS can also develop. In the present study, we investigated learning-related reductions in the magnitude of the unconditioned skin conductance response (SCR). Healthy volunteers participated in a differential conditioning study in which one tone (CS+) was paired with a loud white-noise UCS and a second tone (CS-) was presented alone. In addition, probe trials that consisted of UCS presentations paired with the CS+ (CS + UCS) and CS- (CS - UCS), as well as presentations of the UCS alone were included to assess UCR diminution. SCR and participants' expectations of UCS presentation were monitored during conditioning. Greater diminution of the UCR was observed to the UCS when it followed the CS+ compared to when it followed the CS- or was presented alone. Further, UCR amplitude showed an inverse relationship with the participants' ratings of UCS expectancy. However, conditioned UCR diminution was also observed independent of differential UCS expectancies. Our findings demonstrate conditioned diminution of the unconditioned SCR. Further, these findings suggest that although UCR amplitude is modified by conscious expectations of the UCS, conditioned diminution of the UCR can be expressed independent of learning-related changes in these expectations. (PsycINFO Database Record (c) 2011 APA, all rights reserved).

  16. ADVERSE DRUG REACTION (ADR) MONITORING AND PHARMACOVIGILANCE

    OpenAIRE

    D. KAVITHA

    2013-01-01

    The need for systematic follow up of medicines for adverse drug reactions once they are introduced into general use has been widely recognised today. Even in developing countries like India, national pharmacovigilance programme has been started for monitoring adverse drug reactions. In its first year this program mainly aimed to foster the culture of ADR notification among health care professionals. As a part of health care team every pharmacist must have knowledge about adverse drug reaction...

  17. Magnesium Diboride Superconducting Coils for Adiabatic Demagnetization Refrigerators (ADR's) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — For Adiabatic Demagnetization Refrigerators (ADRs) in space applications, it is desirable to have very light weight, small diameter, high current density...

  18. Development of continuous ADR system for weak gravity missions

    Energy Technology Data Exchange (ETDEWEB)

    Numazawa, T; Kamiya, K [Tsukuba Magnet Laboratory, NIMS, 3-13 Sakura, Tsukuba 305-0003 (Japan); Shirron, P [NASA/Goddard Space Flight Center, Code 552 Greenbelt, MD 20771 (United States); Mitsuda, K [JAXA/ISAS, 3-1-1 Yoshinodai, Sagamihara, Kanagawa 229-8510 (Japan)], E-mail: Numazawa.takenori@nims.go.jp

    2009-02-01

    Adiabatic Demagnetization Refrigeration (ADR) does not use working fluids contrary to conventional refrigerators that make use of the fluid density difference, which leads to superiority of the ADR under the weak gravity condition. In this study, we developed a continuous ADR system to provide constant cooling temperatures {approx}0.1 K. The system consists of four stages of magnetic materials and magnets cascaded with heat switches. The magnetic materials CPA and GdLiF{sub 4} are used for 3 stages between 0.1K and 1.4 K, and single stage between 1.4 K and 4 K, respectively. Passive heat switches are used for the stages > 0.3 K and a superconducting heat switch is used for the continuous stage at {approx}0.1 K. A G-M cycle cooler with a 100 V compressor unit is used to cool the ADR and cryostat shieldings. Total mass of flight model is less than 60 kg. Cooling tests with Transition Edge Sensor on the ground showed that the ADR provided continuous cooling temperatures between 105 mK and 120 mK and it successfully operated the TES. Airborne flight experiments confirmed the ability of the cooling system under the mili-gravity condition. The experimental results showed that the ADR could provide stable temperature under the weak gravity, however, strong vibrations coming from turbulence or takeoff affected to the stability of ADR cycle.

  19. Magnesium Diboride Superconducting Coils for Adiabatic Demagnetization Refrigerators (ADR's) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — For Adiabatic Demagnetization Refrigerators(ADR's) for space it is desirable to have very light weight, small diameter, high current density superconducting wires...

  20. ADR Magnets Operating at 30-40K Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This program is designed to achieve high operational efficiency for superconducting ADR magnets in space, and to meet space launch requirements. The overall...

  1. A new diminutive sisorid catfish (Actinopterygii: Siluriformes) from northeastern India.

    Science.gov (United States)

    Ng, Heok Hee; Lalramliana, Lalramliana; Lalronunga, Samuel

    2016-04-26

    This study describes a new diminutive sisorid catfish from the upper reaches of the Karnaphuli River drainage in northeastern India. The new species can be distinguished from congeners in having a combination of: length of dorsal-fin spine 18.0-21.6% SL; 4-10 serrations on the anterior edge of the dorsal spine; length of pectoral-fin spine 20.7-26.1% SL; length of adipose-fin base 21.5-26.3% SL; body depth at anus 12.3-15.9% SL; caudal peduncle depth 7.5-9.8% SL; caudal peduncle length 17.0-20.5% SL; pale, y-shaped marking on dorsal surface of head; sides of body with pale yellowish patches and irregular bands.

  2. Biological soil crusts: Diminutive communities of potential global importance

    Science.gov (United States)

    Ferrenberg, Scott; Tucker, Colin; Reed, Sasha C.

    2017-01-01

    Biological soil crusts (biocrusts) are widespread, diverse communities of cyanobacteria, fungi, lichens, and mosses living on soil surfaces, primarily in drylands. Biocrusts can locally govern primary production, soil fertility, hydrology, and surface energy balance, with considerable variation in these functions across alternate community states. Further, these communities have been implicated in Earth system functioning via potential influences on global biogeochemistry and climate. Biocrusts are easily destroyed by disturbances and appear to be exceptionally vulnerable to warming temperatures and altered precipitation inputs, signaling possible losses of dryland functions with global change. Despite these concerns, we lack sufficient spatiotemporal data on biocrust function, cover, and community structure to confidently assess their ecological roles across the extensive dryland biome. Here, we present the case for cross-scale research and restoration efforts coupled with remote-sensing and modeling approaches that improve our collective understanding of biocrust responses to global change and the ecological roles of these diminutive communities at global scales.

  3. Digital radiography system, ADR-2000A; Digital gazo shori sochi ADR-2000A

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    A digital radiography system, ADR-2000A has been developed. It provides high-precision images (2,048 by 2,048 pixels), and is applicable to digestive organ examination and angiography. Its major features are: (1) real time collection of the images (2,048 by 2,048 pixels, 10 bits, and 2.5 frames/s), which are useful for diagnosis of, e.g., the esophagus, radiographic timing for which is difficult (2,048 by 2,048 pixels, 10 bits, and 3.75 frames/s), (2) parallel processing for image observation (high-speed image processing), and automatic filing/filming/network image transfer, while the data are being collected, to increase examination through-put, and (3) the advanced PC techniques and the world standard medical image communication techniques adopted to decrease size and weight, and to help systematize hospital jobs, respectively. (translated by NEDO)

  4. Development of magnetic materials for continuous ADR system; Uchu yo ADR jiseitai no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    Numazawa, T.; Sato, A. [National Research Inst. of Metals, Tokyo (Japan); Arai, O. [Tokyo Inst. of Tech., Tokyo (Japan); Canavan, E.; Shirron, P.

    2000-05-29

    Next generation high resolution light quantum detector using micro-calorimeter such as XRS analyzing equipment mounted on Astro-E is at present under development. For these sensors, ultra-low temperature environment below 100 mK is indispensable, and a cooling system capable of generating ultra-low temperature under no coolant and no gravity is desired. This time, the Metallic Materials Research Institute participated in the development program of ADR for space proceeding in GSFC requested by NASA/Goddard space flight Center (GSFC). The feature of this cooling system is that magnetic materials are divided into multiple bodies in order to generate continuously 50 mK for realization of Carnot cycle. Ferric alum is used for lowest temperature generating magnetic material unit and use of DGGG magnetic material is under examination above 1 K. (NEDO)

  5. Mission Design and Simulation Considerations for ADReS-A

    Science.gov (United States)

    Peters, S.; Förstner, R.; Fiedler, H.

    2016-09-01

    Space debris in general has become a major problem for modern space activities. Guidelines to mitigate the threat have been recommended, better prediction models are developed and an advanced observation of objects orbiting Earth is in progress. And still - without the implementation of active debris removal (ADR), the number of debris in space will exponentially increase. To support the ongoing research on ADR-missions, this paper presents the updated mission design of ADReS-A (Autonomous Debris Removal Satellite - #A) - one possible concept for the multiple active removal of large debris in Low Earth orbit, in this case especially of rocket bodies of the SL-8-type. ADReS-A as chaser satellite is supported by at least 5 de-orbit kits, allowing for the same number of targets to be removed. While ADReS-A is conceived for handling of the target, the kit's task is the controlled re-entry of the designated rocket body. The presented mission design forms the basis for the simulation environment in progress. The simulation shall serve as testbed to test multiple scenarios in terms of approach and abort optimization or different tumbling modes of the target. The ultimate goal is the test of autonomous behaviors of the spacecraft in case of unforeseen failures during the approach phase. Considerations to create a simulation for the described mission are presented and discussed. A first visualization of pre-calculated aboard trajectories can be found at the end of this paper.

  6. New genus of diminutive microhylid frogs from Papua New Guinea

    Directory of Open Access Journals (Sweden)

    Fred Kraus

    2010-06-01

    Full Text Available A new genus of diminutive (10.1-11.3 mm microhylid frogs is described from New Guinea that is unique in its combination ofonly seven presacral vertebrae, a reduced phalangeal formula that leaves the first fingers and first toes as vestigial nubs, and reduction of the prepollex and prehallux to single elements. Relationships to other genera are unknown, but overall similarity suggests some relationship to Cophixalus, although that genus also differs in some muscle characters and likely remains paraphyletic. The new genus contains two species, which are among the smallest known frogs in the world. Their miniaturization may be related to their inhabiting leaf litter, exploitation of which may for small size. The new genus is currently known only from one mountaintop in the southeasternmost portion of New Guinea and another on a nearby island. This region is part of the East Papuan Composite Terrane and, should this lineage prove endemic to that region, it may suggest that it originated prior to that geological unit’s docking with mainland New Guinea at 23–29 MY.

  7. Digital Chromoendoscopy for Diagnosis of Diminutive Colorectal Lesions

    Science.gov (United States)

    dos Santos, Carlos Eduardo Oliveira; Malaman, Daniele; Lopes, César Vivian; Pereira-Lima, Júlio Carlos; Parada, Artur Adolfo

    2012-01-01

    Introduction. To compare the accuracy of digital and real-time chromoendoscopy for the differential diagnosis of diminutive (indigo carmine (69 patients/120 lesions) in the analysis of capillary meshwork and pit pattern, respectively. All lesions were less than 5 mm in diameter, and magnification was used in both groups. Histopathology was the gold standard examination. Results. Of 215 colorectal lesions, 153 (71.2%) were adenomas, and 62 were hyperplastic polyps (28.8%). Morphological analysis revealed 132 (61.4%) superficial lesions, with 7 (3.3%) depressed lesions, and 83 (38.6%) protruding lesions. Vascular meshwork analysis using FICE and magnification resulted in 91.7% sensitivity, 95.7% specificity, and 92.6% accuracy in differentiating neoplastic from nonneoplastic lesions. Pit pattern analysis with indigo carmine and magnification showed 96.5% sensitivity, 88.2% specificity, and 94.2% accuracy for the same purpose. Conclusion. Both magnifying virtual chromoendoscopy and indigo carmine chromoendoscopy showed high accuracy in the histopathological diagnosis of colorectal lesions less than 5 mm in diameter. PMID:23082070

  8. Digital Chromoendoscopy for Diagnosis of Diminutive Colorectal Lesions

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Oliveira dos Santos

    2012-01-01

    Full Text Available Introduction. To compare the accuracy of digital and real-time chromoendoscopy for the differential diagnosis of diminutive (<5 mm neoplastic and nonneoplastic colorectal lesions. Materials and Methods. This is a prospective randomized study comparing the Fujinon intelligent color enhancement (FICE system (65 patients/95 lesions and indigo carmine (69 patients/120 lesions in the analysis of capillary meshwork and pit pattern, respectively. All lesions were less than 5 mm in diameter, and magnification was used in both groups. Histopathology was the gold standard examination. Results. Of 215 colorectal lesions, 153 (71.2% were adenomas, and 62 were hyperplastic polyps (28.8%. Morphological analysis revealed 132 (61.4% superficial lesions, with 7 (3.3% depressed lesions, and 83 (38.6% protruding lesions. Vascular meshwork analysis using FICE and magnification resulted in 91.7% sensitivity, 95.7% specificity, and 92.6% accuracy in differentiating neoplastic from nonneoplastic lesions. Pit pattern analysis with indigo carmine and magnification showed 96.5% sensitivity, 88.2% specificity, and 94.2% accuracy for the same purpose. Conclusion. Both magnifying virtual chromoendoscopy and indigo carmine chromoendoscopy showed high accuracy in the histopathological diagnosis of colorectal lesions less than 5 mm in diameter.

  9. Slov. Adráš “Quercus ilex”

    Directory of Open Access Journals (Sweden)

    Milan Grošelj

    1973-12-01

    Full Text Available Slow.adráš " ercus ilex" wird mit berb especie de pino, roble Encino Silvestre, adern chêne à glands deux''aderr 'glands de chene' verglichen, -aš würde dem vorgall. Deminutivsuffix -asso (dieses aus alterem –asto hervorgegangenentsprechen.Auch lat.wird als ein mediterranes Wort betrachtet.

  10. MT-ADRES: Multithreading on Coarse-Grained Reconfigurable Architecture

    DEFF Research Database (Denmark)

    Wu, Kehuai; Kanstein, Andreas; Madsen, Jan

    2007-01-01

    The coarse-grained reconfigurable architecture ADRES (Architecture for Dynamically Reconfigurable Embedded Systems) and its compiler offer high instruction-level parallelism (ILP) to applications by means of a sparsely interconnected array of functional units and register files. As high-ILP archi...

  11. 76 FR 22848 - Alternative Dispute Resolution (ADR) and Conflict Management

    Science.gov (United States)

    2011-04-25

    ... of the Secretary 32 CFR Part 83 RIN 0790-AI63 Alternative Dispute Resolution (ADR) and Conflict... policy and assigns responsibilities. It establishes a framework for encouraging the expanded use of alternative means of dispute resolution and conflict management practices as an integral part of normal...

  12. Application of Reinforced HTS 2212 Wires in ADR Magnets Operating at 30K-40K Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Adiabatic Demagnetization Refrigerators (ADRs) are considered for operations in many space missions. At the heart of an ADR is a magnet that produces the background...

  13. Knowledge creation about ADRs-turning the perspective from the rear mirror to the projector?

    DEFF Research Database (Denmark)

    Aagaard, Lise; Soendergaard, Birthe; Stenver, Doris I

    2008-01-01

    What is already known about this subject? Serious and unexpected adverse drug reactions (ADRs) have been reported shortly after marketing of a number of drugs. Review of ADR cases by the regulatory authorities has resulted in suspension of drugs or restrictions in product information. What...... this study adds? Information about serious and unexpected ADRs of three drugs with reported serious ADRs was already present in the registration files. Observations of these ADRs were not investigated further before marketing. A more active utilization of the ADR information in premarketing studies could...... probably prevent the appearance of unexpected and serious ADR cases after marketing. AIMS: Spontaneous reports of adverse drug reactions (ADRs) are often the only documentation used to justify the recall of drugs from the market. The purpose of this study was to investigate whether it would have been...

  14. The EU-ADR Web Platform: delivering advanced pharmacovigilance tools.

    Science.gov (United States)

    Oliveira, José Luis; Lopes, Pedro; Nunes, Tiago; Campos, David; Boyer, Scott; Ahlberg, Ernst; van Mulligen, Erik M; Kors, Jan A; Singh, Bharat; Furlong, Laura I; Sanz, Ferran; Bauer-Mehren, Anna; Carrascosa, Maria C; Mestres, Jordi; Avillach, Paul; Diallo, Gayo; Díaz Acedo, Carlos; van der Lei, Johan

    2013-05-01

    Pharmacovigilance methods have advanced greatly during the last decades, making post-market drug assessment an essential drug evaluation component. These methods mainly rely on the use of spontaneous reporting systems and health information databases to collect expertise from huge amounts of real-world reports. The EU-ADR Web Platform was built to further facilitate accessing, monitoring and exploring these data, enabling an in-depth analysis of adverse drug reactions risks. The EU-ADR Web Platform exploits the wealth of data collected within a large-scale European initiative, the EU-ADR project. Millions of electronic health records, provided by national health agencies, are mined for specific drug events, which are correlated with literature, protein and pathway data, resulting in a rich drug-event dataset. Next, advanced distributed computing methods are tailored to coordinate the execution of data-mining and statistical analysis tasks. This permits obtaining a ranked drug-event list, removing spurious entries and highlighting relationships with high risk potential. The EU-ADR Web Platform is an open workspace for the integrated analysis of pharmacovigilance datasets. Using this software, researchers can access a variety of tools provided by distinct partners in a single centralized environment. Besides performing standalone drug-event assessments, they can also control the pipeline for an improved batch analysis of custom datasets. Drug-event pairs can be substantiated and statistically analysed within the platform's innovative working environment. A pioneering workspace that helps in explaining the biological path of adverse drug reactions was developed within the EU-ADR project consortium. This tool, targeted at the pharmacovigilance community, is available online at https://bioinformatics.ua.pt/euadr/. Copyright © 2012 John Wiley & Sons, Ltd.

  15. Enforcing consumer rights through ADR at the detriment of consumer law

    NARCIS (Netherlands)

    Loos, M.B.M.

    2016-01-01

    Alternative dispute resolution (ADR) is seen by the European legislator as a key instrument for the enforcement of consumer rights. To further ADR, the EU has adopted the ADR Directive, which was to be implemented by the Member States by 9 July 2015. This article shows that the Directive has

  16. Performance of CT Colonography for Detecting Small Diminutive and Flat Polyps

    Science.gov (United States)

    2010-04-01

    polyps detected at CTC, the appropriate handling of potential diminutive lesions becomes even more apparent. Even at OC, the need to remove or take...CTC-detected diminutive lesions,44 the real controversy regarding the clinical management of polyps detected at CTC relates more to the handling of...J Roentgenol Radium Ther Nucl Med 1963;90:673–87. 41. Togashi K, Shimura K, Konishi F, et al. Prospective observation of small adenomas in patients

  17. Investigation of the cumulative diminution process using the Fibonacci method and fractional calculus

    Science.gov (United States)

    Buyukkilic, F.; Ok Bayrakdar, Z.; Demirhan, D.

    2016-02-01

    In this study, we investigate the cumulative diminution phenomenon for a physical quantity and a diminution process with a constant acquisition quantity in each step in a viscous medium. We analyze the existence of a dynamical mechanism that underlies the success of fractional calculus ​compared with standard mathematics for describing stochastic processes by ​proposing a Fibonacci approach, where we assume that the complex processes evolves cumulatively in fractal space and discrete time. ​Thus, when the differential-integral order α is attained, this indicates the ​involvement of the viscosity of the medium ​in the evolving process. The future value of the diminishing physical quantity is obtained in terms of the Mittag-Leffler function (MLF) and two rheological laws ​are inferred from the asymptotic limits. Thus, we conclude that the differential-integral calculus of fractional mathematics implicitly embodies the cumulative diminution mechanism ​that occurs in a viscous medium.

  18. Proximal Hypospadias

    Science.gov (United States)

    Kraft, Kate H.; Shukla, Aseem R.; Canning, Douglas A.

    2011-01-01

    Hypospadias results from abnormal development of the penis that leaves the urethral meatus proximal to its normal glanular position. Meatal position may be located anywhere along the penile shaft, but more severe forms of hypospadias may have a urethral meatus located at the scrotum or perineum. The spectrum of abnormalities may also include ventral curvature of the penis, a dorsally redundant prepuce, and atrophic corpus spongiosum. Due to the severity of these abnormalities, proximal hypospadias often requires more extensive reconstruction in order to achieve an anatomically and functionally successful result. We review the spectrum of proximal hypospadias etiology, presentation, correction, and possible associated complications. PMID:21516286

  19. Prevalence of sessile serrated adenoma/polyp in hyperplastic-appearing diminutive rectosigmoid polyps.

    Science.gov (United States)

    Ponugoti, Prasanna; Lin, Jingmei; Odze, Robert; Snover, Dale; Kahi, Charles; Rex, Douglas K

    2017-03-01

    The American Society for Gastrointestinal Endoscopy recommends that distal colon hyperplastic lesions can be left in place without resection if adenomatous histology can be excluded with >90% negative predictive value. However, some lesions could be sessile serrated adenomas/polyps (SSA/Ps), which is also precancerous. The aim of this study was to describe the prevalence of SSA/Ps in hyperplastic-appearing diminutive rectosigmoid polyps. We prospectively placed 513 consecutive diminutive rectosigmoid polyps that appeared hyperplastic to an expert endoscopist in individual bottles for pathologic. Each polyp was examined by 3 expert GI pathologists. The prevalence of SSA/P in the study polyps ranged from .6% to 2.1%. The lowest negative predictive value found by the endoscopist for the combination of adenomas plus SSA/Ps was 96.7%. The prevalence of SSA/Ps in diminutive rectosigmoid hyperplastic-appearing polyps is very low. These results support the safety and feasibility of a "do not resect" policy for diminutive hyperplastic-appearing rectosigmoid polyps. Copyright © 2017 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

  20. Real-Time Implementation of Demand Response Programs Based on Open ADR Technology

    OpenAIRE

    Omid Abrishambaf; Pedro Faria; Zita Vale

    2017-01-01

    In the Demand Response (DR) concepts, we witness several barriers that need to be addressed such as, data transferring from promoting entities to demand side. The Open Automated Demand Response (Open ADR) standard specification is a solution for overcoming these barriers. This PhD work proposes a real business model for DR implementation based on Open ADR technology.

  1. Spontaneous ADR reports as a trigger for pharmacogenetic research : a prospective observational study in the Netherlands

    NARCIS (Netherlands)

    van Puijenbroek, Eugène; Conemans, Jean; van Grootheest, Kees

    2009-01-01

    BACKGROUND: Information on genetic polymorphisms in drug-metabolizing enzymes is valuable when analysing the causal relationship between drug intake and an adverse drug reaction (ADR). Patients who have experienced an ADR should be informed about the possible existence of genetic polymorphisms that

  2. Mechanical Design of a 4-Stage ADR for the PIPER mission

    Science.gov (United States)

    James, Bryan L.; Kimball, Mark O.; Shirron, Peter J.; Sampson, Michael A.; Letmate, Richard V.; Jackson, Michael L.

    2017-01-01

    The four 1,280 bolometer detector arrays that will fly on the balloon borne PIPER mission will be cooled by a 4-stage adiabatic demagnetization refrigerator (ADR). Two of the three mechanically independent ADR assemblies provide thermal isolation to their salt pills through Kevlar suspensions while the other provides thermal isolation to its salt pill through the use of bellows and Vespel material. The ADR integrates with the detector arrays and it sits in a large bucket Dewar containing superfluid liquid helium. This paper will describe the complex mechanical design of the PIPER ADR, and summarize the mechanical analysis done to validate the design.The four 1,280 bolometer detector arrays that will fly on the balloon borne PIPER mission will be cooled by a 4-stage adiabatic demagnetization refrigerator (ADR). Two of the three mechanically independent ADR assemblies provide thermal isolation to their salt pills through Kevlar suspensions while the other provides thermal isolation to its salt pill through the use of bellows and Vespel material. The ADR integrates with the detector arrays and it sits in a large bucket Dewar containing superfluid liquid helium. This paper will describe the complex mechanical design of the PIPER ADR, and summarize the mechanical analysis done to validate the design.

  3. Using text-mining techniques in electronic patient records to identify ADRs from medicine use.

    Science.gov (United States)

    Warrer, Pernille; Hansen, Ebba Holme; Juhl-Jensen, Lars; Aagaard, Lise

    2012-05-01

    This literature review included studies that use text-mining techniques in narrative documents stored in electronic patient records (EPRs) to investigate ADRs. We searched PubMed, Embase, Web of Science and International Pharmaceutical Abstracts without restrictions from origin until July 2011. We included empirically based studies on text mining of electronic patient records (EPRs) that focused on detecting ADRs, excluding those that investigated adverse events not related to medicine use. We extracted information on study populations, EPR data sources, frequencies and types of the identified ADRs, medicines associated with ADRs, text-mining algorithms used and their performance. Seven studies, all from the United States, were eligible for inclusion in the review. Studies were published from 2001, the majority between 2009 and 2010. Text-mining techniques varied over time from simple free text searching of outpatient visit notes and inpatient discharge summaries to more advanced techniques involving natural language processing (NLP) of inpatient discharge summaries. Performance appeared to increase with the use of NLP, although many ADRs were still missed. Due to differences in study design and populations, various types of ADRs were identified and thus we could not make comparisons across studies. The review underscores the feasibility and potential of text mining to investigate narrative documents in EPRs for ADRs. However, more empirical studies are needed to evaluate whether text mining of EPRs can be used systematically to collect new information about ADRs. © 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society.

  4. Structures and processes in spontaneous ADR reporting systems: a comparative study of Australia and Denmark.

    Science.gov (United States)

    Aagaard, Lise; Stenver, Doris Irene; Hansen, Ebba Holme

    2008-10-01

    To explore the organisational structure and processes of the Danish and Australian spontaneous ADR reporting systems with a view to how information is generated about new ADRs. The Danish and Australian spontaneous ADR reporting systems. Qualitative analyses of documentary material, descriptive interviews with key informants, and observations were made. We analysed the organisational structure of the Danish and Australian ADR reporting systems with respect to structures and processes, including information flow and exchange of ADR data. The analysis was made based on Scott's adapted version of Leavitt's diamond model, with the components: goals/tasks, social structure, technology and participants, within a surrounding environment. The main differences between the systems were: (1) PARTICIPANTS: Outsourcing of ADR assessments to the pharmaceutical companies complicates maintenance of scientific skills within the Danish Medicines Agency (DKMA), as it leaves the handling of spontaneous ADR reports purely administrative within the DKMA, and the knowledge creation process remains with the pharmaceutical companies, while in Australia senior scientific staff work with evaluation of the ADR report; (2) Goals/tasks: In Denmark, resources are targeted at evaluating Periodic Safety Update Reports (PSUR) submitted by the companies, while the resources in Australia are focused on single case assessment resulting in faster and more proactive medicine surveillance; (3) Social structure: Discussions between scientific staff about ADRs take place in Australia, while the Danish system primarily focuses on entering and forwarding ADR data to the relevant pharmaceutical companies; (4) Technology: The Danish system exchanges ADR data electronically with pharmaceutical companies and the other EU countries, while Australia does not have a system for electronic exchange of ADR data; and (5) ENVIRONMENT: The Danish ADR system is embedded in the routines of cooperation within European

  5. Prospective assessment of NSAIDs induced ADRs in orthopaedic in-patients

    Directory of Open Access Journals (Sweden)

    Padmanabha TS, Bhaskara K, Nandini T

    2014-04-01

    Full Text Available Background and Objectives: nonsteroidal anti-inflammatory drugs (NSAIDs are one among the most widely used medications to treat pain and inflammation condition. But inadvertent use of NSAIDs have resulted in gastric upset and even death. Hence to minimize such consequences and to identify the incidence of the Adverse drug reaction (ADRs due to NSAIDs in orthopaedic in-patients to promote rational prescribing. Materials and Methods: A prospective study was done in one hundred orthopaedic in-patients of a tertiary care hospital for 3 months from June-Augest 2012. The ADRs pattern were noted with respect to age, gender and drugs involved . The causality of ADRs were assessed by Naranjo’s Algorithm. Results: Among one hundred in- patients 16% developed ADR due to NSAIDs and 1.92% due to Antimicrobial agents (AMAs. The ADRs were more in males (11% than females (5%. Most prescribed NSAID was Diclofenac (76 %, and least was nimesulide (2%. Others were Paracetamol (16%, Ibuprofen (3% and Etoricoxib (3% . Out of 16 ADRs Tablet (Tab Diclofenac accounted for maximum number {87.5%, (n=14} of ADRs, followed by Tab. Paracetamol {12.5 % (n=2}. Conclusion: ADR incidence rate in orthopaedic in-patient due to NSAIDs was 16%. Educating, establishment and encouragement of Pharmacovigilance system among medical and non-health professionals including medical undergraduates improve ADRs identification and to identify the drugs causing it, therefore prolonged hospitalization, treatment cost, morbidity and mortalities can be minimized. Hence, further ADRs due to particular drugs can be reduced in other patients with rational prescription.

  6. [Drug resistance reversal of HL-60/ADR cells by simultaneous suppression of XIAP and MRP].

    Science.gov (United States)

    Wang, Xiao-Fang; Wang, Chun; Qin, You-Wen; Yan, Shi-Ke; Gao, Yan-Rong

    2006-12-01

    This study was purposed to explore the mechanisms of drug resistance of HL-60/ADR cells and to compare the reversal drug-resistance effects of antisense oligonucleotides (AS ODN) of XIAP (X-linked inhibitor of apoptosis protein) and AS ODNs of MRP (multidrug resistance-associated protein) by use alone or in combination. Reverse transcription-PCR and Western blot were applied to detect the expression of XIAP, BCL-2, MRP and MDR1 in mRNA and protein levels of HL-60 cells and HL-60/ADR cells, respectively. Fully phosphorothioated AS ODN of XIAP and MRP was delivered into HL-60/ADR cells with Lipofectamine 2000 in the form of liposome-ODN complexes alone or in combination. CCK-8 cell viability assay was used to determine the effect of AS ODN of XIAP and MRP used alone or in combination on the chemotherapy sensitivity of HL-60/ADR cells to daunorubicin (DNR). Reverse transcription-PCR and Western blot were applied to examine the changes of XIAP, MRP in mRNA and protein levels respectively. The results showed that MRP and XIAP were both significantly higher in HL-60/ADR cells than those in HL-60 cells. AS ODN of XIAP and MRP down-regulated the expression of XIAP and MRP in HL-60/ADR cells and increased the sensitivity of HL-60/ADR cells to DNR, respectively. AS ODN of XIAP + MRP did not enhance the inhibition expression of XIAP in HL-60/ADR cells but increased the sensitivity of HL-60/ADR cells to DNR significantly as compared with AS ODN of XIAP (P MRP did not increase the concentration of DNR nor enhanced the inhibition expression of MRP in HL-60/ADR cells but increased the sensitivity of HL-60/ADR cells to DNR significantly (P MRP. It is concluded that both XIAP and MRP may be involved in the drug resistance mechanisms of HL-60/ADR cells. Drug-resistance of HL-60/ADR cells can be reversed significantly when antisense oligonucleotides of XIAP and MRP were used in combination.

  7. Cooperative and diminutive effects of pnicogen bonds and cation-π interactions.

    Science.gov (United States)

    Li, Qingzhong; Zhuo, Hongying; Yang, Xin; Cheng, Jianbo; Li, Wenzuo; Loffredo, Robert E

    2014-02-24

    The interplay between pnicogen bonds and cation-π interactions has been investigated at the MP2/aug-cc-pVDZ level. Interesting cooperative and diminutive effects are observed when pnicogen bonds and cation-π interactions coexist in the same complex. These effects have been analyzed in terms of the structural, energetic, and charge-transfer properties of the complexes. The variations in electron density at critical points of the intermolecular bond have been used to analyze bond strengthening or weakening. The nature of the interactions and the mechanisms of cooperative and diminutive effects have been studied by means of symmetry-adapted perturbation theory and molecular electrostatic potentials. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. An enigmatic, diminutive theropod footprint in the shallow marine Pliensbachian Hasle Formation, Bornholm, Denmark

    DEFF Research Database (Denmark)

    Milàn, Jesper; Surlyk, Finn

    2015-01-01

    A well-preserved three-toed footprint, measuring 34 mm in length from a very small predatory dinosaur with an estimated hip height of 153 mm and a total body length around 50 cm including tail, is reported from the type section of the marine Lower Jurassic (Pliensbachian), Hasle Formation...... on the Danish island of Bornholm in the Baltic Sea. The morphology of the footprint is similar to the ichnogenus Stenonyx Lull 1904 from the contemporaneous Pliensbachian Szydlowek site in Poland. Apart from the Polish material, footprints from diminutive dinosaurs are rare and reported from few other...... localities around the world. The occurrence of a diminutive dinosaur footprint in a shallow marine sandstone is enigmatic. The well-defined morphology of the footprint, together with the very small size of the trackmaker, excludes the possibility that the track was emplaced by a swimming or wading animal...

  9. Gastroenterology trainees can easily learn histologic characterization of diminutive colorectal polyps with narrow band imaging.

    Science.gov (United States)

    Patel, Swati G; Rastogi, Amit; Austin, Gregory; Hall, Matthew; Siller, Brittany A; Berman, Kenneth; Yen, Roy; Bansal, Ajay; Ahnen, Dennis J; Wani, Sachin

    2013-08-01

    Little is known about how teaching gastroenterology trainees polyp patterns by using narrow band imaging (NBI) affects their ability to characterize the histology of diminutive colorectal polyps. We developed and tested a tool to teach trainees to characterize the histology of diminutive polyps by using NBI. Twelve gastroenterology trainees with varying levels of colonoscopy experience watched a teaching tool that described the NBI criteria to distinguish polyp histology. The trainees then watched 80 videos of NBI examination of diminutive polyps, recording their predictions of polyp histology and their degree of confidence. After each video, an expert provided feedback about actual polyp histology and the NBI criteria that supported each diagnosis. Twelve weeks later, without training or feedback during the interval, the trainees watched the same videos and predicted histologies of the polyps. Performance was evaluated by comparing predicted classification with actual histologic findings. Cumulative sum analysis was used to determine the learning curve for each trainee. Trainees made significant improvements in accuracy and the proportion of high-confidence predictions as they progressed through video blocks during the first session (P polyp histologies with >90% accuracy, with a negative predictive value >90% for adenomatous histology. A median of 49 videos was required to achieve competency. For diagnoses made with high confidence, trainee performance exceeded 90% during the first and second sessions. Interobserver agreement was substantial (session 1, κ = 0.71; session 2, κ = 0.70). We developed a computer-based tool, combined with short videos and active feedback, to train gastroenterologists to identify polyp histology by using NBI. After training, gastroenterology trainees characterized the histology of diminutive polyps with ≥ 90% accuracy. Published by Elsevier Inc.

  10. Resection of Diminutive and Small Colorectal Polyps: What Is the Optimal Technique?

    OpenAIRE

    Lee, Jun

    2016-01-01

    Colorectal polyps are classified as neoplastic or non-neoplastic on the basis of malignant potential. All neoplastic polyps should be completely removed because both the incidence of colorectal cancer and the mortality of colorectal cancer patients have been found to be strongly correlated with incomplete polypectomy. The majority of colorectal polyps discovered on diagnostic colonoscopy are diminutive and small polyps; therefore, complete resection of these polyps is very important. However,...

  11. A study on the impediment of thickness diminution of carbon steel tube using applied magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong Oh; Hong, Seong Min [Chungnam National Univ., Taejon (Korea, Republic of); Park, Yun Won [Korea Institute of Nuclear Safety, Taejon (Korea, Republic of)

    2002-03-15

    Carbon steel pipe is used as a pipe laying for the cooling water of nuclear reactor. In order to examine the diminution of steel thickness, the magnetic field permeability of applicable permanent magnets was simulated by computer. The susceptibility of the permanent magnets according to the temperature was measured to investigate the applicability of permanent magnets at the cooling water temperature of nuclear power plant. The structure and magnetic properties of carbon steel tube were observed regarding to the existence of oxidized layer.

  12. A revisit on the current practice of dispute resolution and ADR in the Malaysian construction industry

    Directory of Open Access Journals (Sweden)

    Mohd Suhaimi Mohd Danuri

    2012-06-01

    Full Text Available The current dispute resolution procedures available in the Malaysian construction industry are mainly litigation and arbitration. In addition, the alternative dispute resolutions (ADR, namely mediation and adjudication, have also been introduced as the other methods for resolving disputes. The objective of this study is to examine the current practice of dispute resolution and ADR available in the Malaysian construction industry. The aim of this paper is two-fold: to report the current practice of dispute resolution and ADR, and identify the attributes of successful implementation of both mechanisms based on the perceptions of the Malaysian construction industry players. From the jurisprudence point of view, this study looks into the law as it is, in relation to the current practice of dispute resolution and ADR, by showing how those findings can be used to explain why improvement is needed to promote a successful and well received dispute resolution and ADR, and what lessons can be learnt, towards the formulation of a more viable methods for the Malaysian construction industry. NVivo software has been used to manage and organise the complete interview transcripts and facilitate the data analysis process for this study. Literature review reveals a continuous development of dispute resolution and ADR in the Malaysian construction industry, while, globally the industry has not only embraced ADR but also spearheaded the development of innovative forms of dispute avoidance mechanism. The findings of interviews show that locally, apart from litigation, the common types of ADR are arbitration, mediation and ad hoc mechanism. The findings also lead to the discovery of the following attributes: faster, less procedural, cost effective and enforceable; regulation and government's support; professionalism and ethic; training; and facility, that may promote a successful implementation of dispute resolution and ADR in Malaysia.

  13. Development of an End-to-End Active Debris Removal (ADR) Mission Strategic Plan Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Since the majority of the potential ADR targets are large (>meters) upper stages and payloads between 800 and 1100 km altitude, they are relatively bright, with...

  14. Low Heat-Leak YBCO Leads for Satellite-Borne ADR Magnets Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Future satellite missions carrying X-ray spectrometers will be cooled to milliKelvin temperatures by multi-stage Adiabatic Demagnetization Refrigerators (ADR),...

  15. Low-Frequency, All Digital Radar (ADR) for Biomass and Ice-sheet Investigations Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Low-Frequency, All Digital Radar (ADR) can be a key component for NASA Phased-array and tomographic Radar systems spanning multiple earth-science measurement...

  16. The EU-ADR project: preliminary results and perspective.

    Science.gov (United States)

    Trifiro, Gianluca; Fourrier-Reglat, Annie; Sturkenboom, Miriam C J M; Díaz Acedo, Carlos; Van Der Lei, Johan

    2009-01-01

    The EU-ADR project aims to exploit different European electronic healthcare records (EHR) databases for drug safety signal detection. In this paper we describe the project framework and the preliminary results. As first step we created a ranked list of the events that are deemed to be important in pharmacovigilance as mining on all possible events was considered to unduly increase the number of spurious signals. All the drugs that are potentially associated to these events will be detected via data mining techniques. Data sources are eight 8 databases in four countries (Denmark, Italy, the Netherlands, and the United Kingdom) that are virtually linked through harmonisation of input data followed by local elaboration of input data through custom-built software (Jerboa). All the identified drug-event associations (signals) will be thereafter biologically substantiated and epidemiologically validated. To date, only Upper gastrointestinal bleeding (UGIB) event has been used to test the ability of the system in signal detection. An initial ranked list comprising 23 adverse events was identified. The top-ranking events were: cutaneous bullous eruptions, acute renal failure, acute myocardial infarction, anaphylactic shock, and rhabdomyolysis. Regarding the UGIB test, a total of 48,016 first-ever episodes were identified. The age-standardized incidence rates of UGIB varied between 40-100/100,000 person-years depending on country and type of healthcare database. A statistically significant association between use of NSAIDs and UGIB was detected in all of the databases. a dynamic ranked list of 23 adverse drug events judged as important in pharmacovigilance was created to permit focused data mining. Preliminary results on the UGIB event detection demonstrate the feasibility of harmonizing various health care databases in different European countries through a distributed network approach.

  17. A systematic investigation of computation models for predicting Adverse Drug Reactions (ADRs.

    Directory of Open Access Journals (Sweden)

    Qifan Kuang

    Full Text Available BACKGROUND: Early and accurate identification of adverse drug reactions (ADRs is critically important for drug development and clinical safety. Computer-aided prediction of ADRs has attracted increasing attention in recent years, and many computational models have been proposed. However, because of the lack of systematic analysis and comparison of the different computational models, there remain limitations in designing more effective algorithms and selecting more useful features. There is therefore an urgent need to review and analyze previous computation models to obtain general conclusions that can provide useful guidance to construct more effective computational models to predict ADRs. PRINCIPAL FINDINGS: In the current study, the main work is to compare and analyze the performance of existing computational methods to predict ADRs, by implementing and evaluating additional algorithms that have been earlier used for predicting drug targets. Our results indicated that topological and intrinsic features were complementary to an extent and the Jaccard coefficient had an important and general effect on the prediction of drug-ADR associations. By comparing the structure of each algorithm, final formulas of these algorithms were all converted to linear model in form, based on this finding we propose a new algorithm called the general weighted profile method and it yielded the best overall performance among the algorithms investigated in this paper. CONCLUSION: Several meaningful conclusions and useful findings regarding the prediction of ADRs are provided for selecting optimal features and algorithms.

  18. Interaction and sonodynamic damage activity of acridine red (AD-R) to bovine serum albumin (BSA)

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Dandan; Xie, Jinhui; Wu, Qiong; Fan, Ping; Wang, Jun, E-mail: wangjun888tg@126.com

    2015-04-15

    The sonodynamic therapy (SDT) has become an attractive antitumor treatment method in recent years, but the selection of sonosensitizer, mechanism of damage biomolecule and kind of reactive oxygen species (ROS) generated during sonodynamic process have not been investigated in detail. In this paper, the acridine red (AD-R), as a sonosensitizer, combining with ultrasonic irradiation to damage bovine serum albumin (BSA) was investigated. At first, the interaction of AD-R to BSA molecules in aqueous solution was studied by fluorescence spectroscopy. As judged from the experimental results, the quenching mechanism of BSA fluorescence belongs to a static process. Synchronous fluorescence spectra demonstrate that the binding and damage sites to BSA molecules are mainly on the tryptophan residues. The generation and kind of generated ROS were also estimated by the method of oxidation and extraction photometry. This paper may offer some valuable references for the study of the sonodynamic activity and application of AD-R in SDT for tumor treatment. - Highlights: ●Acridine red (AD-R) is used to study interaction with BSA. ●Spectroscopy is used to study sonodynamic damage activity of AD-R to BSA. ●Generation of ROS caused by AD-R under ultrasonic irradiation was determined.

  19. Neural mechanisms underlying the conditioned diminution of the unconditioned fear response.

    Science.gov (United States)

    Wood, Kimberly H; Ver Hoef, Lawrence W; Knight, David C

    2012-03-01

    Recognizing cues that predict an aversive event allows one to react more effectively under threatening conditions, and minimizes the reaction to the threat itself. This is demonstrated during Pavlovian fear conditioning when the unconditioned response (UCR) to a predictable unconditioned stimulus (UCS) is diminished compared to the UCR to an unpredictable UCS. The present study investigated the functional magnetic resonance imaging (fMRI) signal response associated with Pavlovian conditioned UCR diminution to better understand the relationship between individual differences in behavior and the neural mechanisms of the threat-related emotional response. Healthy volunteers participated in a fear conditioning study in which trait anxiety, skin conductance response (SCR), UCS expectancy, and the fMRI signal were assessed. During acquisition trials, a tone (CS+) was paired with a white noise UCS and a second tone (CS-) was presented without the UCS. Test trials consisted of the CS+ paired with the UCS, CS- paired with the UCS, and presentations of the UCS alone to assess conditioned UCR diminution. UCR diminution was observed within the dorsolateral PFC, dorsomedial PFC, cingulate cortex, inferior parietal lobule (IPL), anterior insula, and amygdala. The threat-related activity within the dorsolateral PFC, dorsomedial PFC, posterior cingulate cortex, and IPL varied with individual differences in trait anxiety. In addition, anticipatory (i.e. CS elicited) activity within the PFC showed an inverse relationship with threat-related (i.e. UCS elicited) activity within the PFC, IPL, and amygdala. Further, the emotional response (indexed via SCR) elicited by the threat was closely linked to amygdala activity. These findings are consistent with the view that the amygdala and PFC support learning-related processes that influence the emotional response evoked by a threat. Copyright © 2011 Elsevier Inc. All rights reserved.

  20. Information about ADRs explored by pharmacovigilance approaches: a qualitative review of studies on antibiotics, SSRIs and NSAIDs

    Science.gov (United States)

    Aagaard, Lise; Hansen, Ebba Holme

    2009-01-01

    Background Despite surveillance efforts, unexpected and serious adverse drug reactions (ADRs) repeatedly occur after marketing. The aim of this article is to analyse ADRs reported by available ADR signal detection approaches and to explore which information about new and unexpected ADRs these approaches have detected. Methods We selected three therapeutic cases for the review: antibiotics for systemic use, non-steroidal anti-inflammatory medicines (NSAID) and selective serotonin re-uptake inhibitors (SSRI). These groups are widely used and represent different therapeutic classes of medicines. The ADR studies were identified through literature search in Medline and Embase. The search was conducted in July 2007. For each therapeutic case, we analysed the time of publication, the strengths of the evidence of safety in the different approaches, reported ADRs and whether the studies have produced new information about ADRs compared to the information available at the time of marketing. Results 79 studies were eligible for inclusion in the analysis: 23 antibiotics studies, 35 NSAID studies, 20 SSRI studies. Studies were mainly published from the end of the 1990s and onwards. Although the drugs were launched in different decades, both analytical and observational approaches to ADR studies were similar for all three therapeutic cases: antibiotics, NSAIDs and SSRIs. The studies primarily dealt with analyses of ADRs of the type A and B and to a lesser extent C and D, cf. Rawlins' classification system. The therapeutic cases provided similar results with regard to detecting information about new ADRs despite different time periods and organs attacked. Approaches ranging higher in the evidence hierarchy provided information about risks of already known or expected ADRs, while information about new and previously unknown ADRs was only detected by case reports, the lowest ranking approach in the evidence hierarchy. Conclusion Although the medicines were launched in different

  1. Operation of an ADR using helium exchange gas as a substitute for a failed heat switch

    Science.gov (United States)

    Shirron, P.; DiPirro, M.; Kimball, M.; Sneiderman, G.; Porter, F. S.; Kilbourne, C.; Kelley, R.; Fujimoto, R.; Yoshida, S.; Takei, Y.; Mitsuda, K.

    2014-11-01

    The Soft X-ray Spectrometer (SXS) is one of four instruments on the Japanese Astro-H mission, which is currently planned for launch in late 2015. The SXS will perform imaging spectroscopy in the soft X-ray band (0.3-12 keV) using a 6 × 6 pixel array of microcalorimeters cooled to 50 mK. The detectors are cooled by a 3-stage adiabatic demagnetization refrigerator (ADR) that rejects heat to either a superfluid helium tank (at 1.2 K) or to a 4.5 K Joule-Thomson (JT) cryocooler. Four gas-gap heat switches are used in the assembly to manage heat flow between the ADR stages and the heat sinks. The engineering model (EM) ADR was assembled and performance tested at NASA/GSFC in November 2011, and subsequently installed in the EM dewar at Sumitomo Heavy Industries, Japan. During the first cooldown in July 2012, a failure of the heat switch that linked the two colder stages of the ADR to the helium tank was observed. Operation of the ADR requires some mechanism for thermally linking the salt pills to the heat sink, and then thermally isolating them. With the failed heat switch unable to perform this function, an alternate plan was devised which used carefully controlled amounts of exchange gas in the dewar's guard vacuum to facilitate heat exchange. The process was successfully demonstrated in November 2012, allowing the ADR to cool the detectors to 50 mK for hold times in excess of 10 h. This paper describes the exchange-gas-assisted recycling process, and the strategies used to avoid helium contamination of the detectors at low temperature.

  2. Operation of an ADR Using Helium Exchange Gas as a Substitute for a Failed Heat Switch

    Science.gov (United States)

    Shirron, P.; DiPirro, M.; Kimball, M.; Sneiderman, G.; Porter, F. S.; Kilbourne, C.; Kelley, R.; Fujimoto, R.; Yoshida, S.; Takei, Y.; hide

    2014-01-01

    The Soft X-ray Spectrometer (SXS) is one of four instruments on the Japanese Astro-H mission, which is currently planned for launch in late 2015. The SXS will perform imaging spectroscopy in the soft X-ray band (0.3-12 keV) using a 6 6 pixel array of microcalorimeters cooled to 50 mK. The detectors are cooled by a 3-stage adiabatic demagnetization refrigerator (ADR) that rejects heat to either a superfluid helium tank (at 1.2 K) or to a 4.5 K Joule-Thomson (JT) cryocooler. Four gas-gap heat switches are used in the assembly to manage heat flow between the ADR stages and the heat sinks. The engineering model (EM) ADR was assembled and performance tested at NASA/GSFC in November 2011, and subsequently installed in the EM dewar at Sumitomo Heavy Industries, Japan. During the first cooldown in July 2012, a failure of the heat switch that linked the two colder stages of the ADR to the helium tank was observed. Operation of the ADR requires some mechanism for thermally linking the salt pills to the heat sink, and then thermally isolating them. With the failed heat switch unable to perform this function, an alternate plan was devised which used carefully controlled amounts of exchange gas in the dewar's guard vacuum to facilitate heat exchange. The process was successfully demonstrated in November 2012, allowing the ADR to cool the detectors to 50 mK for hold times in excess of 10 h. This paper describes the exchange-gas-assisted recycling process, and the strategies used to avoid helium contamination of the detectors at low temperature.

  3. Proximal renal tubular acidosis

    Science.gov (United States)

    Renal tubular acidosis - proximal; Type II RTA; RTA - proximal; Renal tubular acidosis type II ... by alkaline substances, mainly bicarbonate. Proximal renal tubular acidosis (Type II RTA) occurs when bicarbonate is not ...

  4. EU-ADR healthcare database network vs. spontaneous reporting system database: preliminary comparison of signal detection.

    Science.gov (United States)

    Trifirò, Gianluca; Patadia, Vaishali; Schuemie, Martijn J; Coloma, Preciosa M; Gini, Rosa; Herings, Ron; Hippisley-Cox, Julia; Mazzaglia, Giampiero; Giaquinto, Carlo; Scotti, Lorenza; Pedersen, Lars; Avillach, Paul; Sturkenboom, Miriam C J M; van der Lei, Johan; Eu-Adr Group

    2011-01-01

    The EU-ADR project aims to exploit different European electronic healthcare records (EHR) databases for drug safety signal detection. In this paper we report the preliminary results concerning the comparison of signal detection between EU-ADR network and two spontaneous reporting databases, the Food and Drug Administration and World Health Organization databases. EU-ADR data sources consist of eight databases in four countries (Denmark, Italy, Netherlands, and United Kingdom) that are virtually linked through distributed data network. A custom-built software (Jerboa©) elaborates harmonized input data that are produced locally and generates aggregated data which are then stored in a central repository. Those data are subsequently analyzed through different statistics (i.e. Longitudinal Gamma Poisson Shrinker). As potential signals, all the drugs that are associated to six events of interest (bullous eruptions - BE, acute renal failure - ARF, acute myocardial infarction - AMI, anaphylactic shock - AS, rhabdomyolysis - RHABD, and upper gastrointestinal bleeding - UGIB) have been detected via different data mining techniques in the two systems. Subsequently a comparison concerning the number of drugs that could be investigated and the potential signals detected for each event in the spontaneous reporting systems (SRSs) and EU-ADR network was made. SRSs could explore, as potential signals, a larger number of drugs for the six events, in comparison to EU-ADR (range: 630-3,393 vs. 87-856), particularly for those events commonly thought to be potentially drug-induced (i.e. BE: 3,393 vs. 228). The highest proportion of signals detected in SRSs was found for BE, ARF and AS, while for ARF, and UGIB in EU-ADR. In conclusion, it seems that EU-ADR longitudinal database network may complement traditional spontaneous reporting system for signal detection, especially for those adverse events that are frequent in general population and are not commonly thought to be drug

  5. The "valley sign" in small and diminutive adenomas: prevalence, interobserver agreement, and validation as an adenoma marker.

    Science.gov (United States)

    Rex, Douglas K; Ponugoti, Prasanna; Kahi, Charles

    2017-03-01

    Classification schemes for differentiation of conventional colorectal adenomas from serrated lesions rely on patterns of blood vessels and pits. Morphologic features have not been validated as predictors of histology. The aim of this study was to describe the prevalence of the "valley sign" and validate it as a marker of conventional adenomas. Three experts judged the prevalence of the valley sign in 301 consecutive small adenomas. Medical students were taught to recognize the valley and were tested on their recognition of the valley sign. Consecutive diminutive polyps were video-recorded and used to validate the association of the valley sign with conventional adenomas. The prevalence of the valley sign in 301 consecutive adenomas sign and recognized it with accuracy of 96% or higher in 50 selected photographs of diminutive polyps. Four medical students evaluated video-recordings of 170 consecutive diminutive polyps for the presence of the valley sign. Kappa values for the interpretation of the valley sign ranged from 0.52 to 0.68 among the students. The sensitivity of the valley sign for adenoma ranged from 40.2% to 54.9%, and specificity ranged from 90.2% to 91.7%. The valley sign was strongly associated with adenomas (P sign is insensitive but highly specific for conventional adenoma in diminutive polyps. It may enhance classification schemes for differentiation of adenomas from serrated lesions based on vessels and pits. Copyright © 2017 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

  6. Masculinos y femeninos en funcion diminutiva y aumentativa (Masculine and Feminine Genders Used in Diminutive and Augmentative Functions)

    Science.gov (United States)

    Carnicer, Ramon

    1975-01-01

    Some Spanish nouns designating non-animate things may have either feminine or masculine gender. The reasons given for the choice of gender are many and varied. It is put forward that in some cases the masculine acts as a diminutive and the feminine as an augmentative. (Text is in Spanish.) (TL)

  7. The proportion of patient reports of suspected ADRs to signal detection in the Netherlands : case-control study

    NARCIS (Netherlands)

    van Hunsel, Florence; Talsma, Attje; van Puijenbroek, Eugène; de Jong-van den Berg, Lolkje; van Grootheest, Kees

    Aim To determine the contribution of patients' adverse drug reaction (ADR) reports to signals detection, through a study of the signals sent by Lareb to the Dutch Medicines Evaluation Board. Methods The percentage of patient's ADR reports contributing to generate signals of adverse drug reactions

  8. Thermodynamic Performance of the 3-Stage ADR for the Astro-H Soft X-Ray Spectrometer Instrument

    Science.gov (United States)

    Shirron, Peter J.; Kimball, Mark O.; James, Bryan L.; Muench, Theodore; DiPirro, Michael J.; Bialas, Thomas G.; Sneiderman, Gary A.; Porter, Frederick S.; Kelley, Richard L.

    2015-01-01

    The Soft X-ray Spectrometer (SXS) instrument[1] on Astro-H[2] will use a 3-stage ADR[3] to cool the microcalorimeter array to 50 mK. In the primary operating mode, two stages of the ADR cool the detectors using superfluid helium at =1.20 K as the heat sink[4]. In the secondary mode, which is activated when the liquid helium is depleted, the ADR uses a 4.5 K Joule-Thomson cooler as its heat sink. In this mode, all three stages operate together to continuously cool the (empty) helium tank and singleshot cool the detectors. The flight instrument - dewar, ADR, detectors and electronics - were integrated in 2014 and have since undergone extensive performance testing. This paper presents a thermodynamic analysis of the ADR's operation, including cooling capacity, heat rejection to the heat sinks, and various measures of efficiency.

  9. 26 CFR 12.4 - Election of Class Life Asset Depreciation Range System (ADR).

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 14 2010-04-01 2010-04-01 false Election of Class Life Asset Depreciation Range... Election of Class Life Asset Depreciation Range System (ADR). (a) Elections filed before February 1, 1972... tax return in accordance with § 1.167(a)-11 of this chapter (relating to depreciation allowances using...

  10. Using text-mining techniques in electronic patient records to identify ADRs from medicine use

    DEFF Research Database (Denmark)

    Warrer, Pernille; Hansen, Ebba Holme; Jensen, Lars Juhl

    2012-01-01

    searching of outpatient visit notes and inpatient discharge summaries to more advanced techniques involving natural language processing (NLP) of inpatient discharge summaries. Performance appeared to increase with the use of NLP, although many ADRs were still missed. Due to differences in study design...

  11. MT-ADRES: multi-threading on coarse-grained reconfigurable architecture

    DEFF Research Database (Denmark)

    Wu, Kehuai; Kanstein, Andreas; Madsen, Jan

    2008-01-01

    The coarse-grained reconfigurable architecture ADRES (architecture for dynamically reconfigurable embedded systems) and its compiler offer high instruction-level parallelism (ILP) to applications by means of a sparsely interconnected array of functional units and register files. As high-ILP archi...

  12. Fast Screening Technology for Drug Emergency Management: Predicting Suspicious SNPs for ADR with Information Theory-based Models.

    Science.gov (United States)

    Liang, Zhaohui; Liu, Jun; Huang, Jimmy Xiangji; Zeng, Xing

    2018-01-14

    The genetic polymorphism of Cytochrome P450 (CYP 450) is considered as one of the main causes for adverse drug reactions (ADRs). In order to explore the latent correlations between ADRs and potentially corresponding single-nucleotide polymorphism (SNPs) in CYP450, three algorithms based on information theory are used as the main method to predict the possible relation. The study uses a retrospective case-control study to explore the potential relation of ADRs to specific genomic locations and single-nucleotide polymorphism (SNP). The genomic data collected from 53 healthy volunteers are applied for the analysis, another group of genomic data collected from 30 healthy volunteers excluded from the study are used as the control group. The SNPs respective on five loci of CYP2D6*2,*10,*14 and CYP1A2*1C, *1F are detected by the Applied Biosystem 3130xl. The raw data is processed by ChromasPro to detected the specific alleles on the above loci from each sample. The secondary data are reorganized and processed by R combined with the reports of ADRs from clinical reports. Three information theory based algorithms are implemented for the screening task: JMI, CMIM, and mRMR. If a SNP is selected by more than two algorithms, we are confident to conclude that it is related to the corresponding ADR. The selection results are compared with the control decision tree + LASSO regression model. In the study group where ADRs occur, 10 SNPs are considered relevant to the occurrence of a specific ADR by the combined information theory model. In comparison, only 5 SNPs are considered relevant to a specific ADR by the decision tree + LASSO regression model. In addition, the new method detects more relevant pairs of SNP and ADR which are affected both by SNP and dosage. This implies that the new information theory based model is effective to discover correlations of ADRs and CYP 450 SNPs and is helpful to predict the potential vulnerable genotype for some ADRs. The newly proposed

  13. Piriformospora indica rescues growth diminution of rice seedlings during high salt stress.

    Science.gov (United States)

    Jogawat, Abhimanyu; Saha, Shreya; Bakshi, Madhunita; Dayaman, Vikram; Kumar, Manoj; Dua, Meenakshi; Varma, Ajit; Oelmüller, Ralf; Tuteja, Narendra; Johri, Atul Kumar

    2013-10-01

    Piriformospora indica association has been reported to increase biotic as well as abiotic stress tolerance of its host plants. We analyzed the beneficial effect of P. indica association on rice seedlings during high salt stress conditions (200 and 300 mM NaCl). The growth parameters of rice seedlings such as root and shoot lengths or fresh and dry weights were found to be enhanced in P. indica-inoculated rice seedlings as compared with non-inoculated control seedlings, irrespective of whether they are exposed to salt stress or not. However, salt-stressed seedlings performed much better in the presence of the fungus compared with non-inoculated control seedlings. The photosynthetic pigment content [chlorophyll (Chl) a, Chl b, and carotenoids] was significantly higher in P. indica-inoculated rice seedlings under high salt stress conditions as compared with salt-treated non-inoculated rice seedlings, in which these pigments were found to be decreased. Proline accumulation was also observed during P. indica colonization, which may help the inoculated plants to become salt tolerant. Taken together, P. indica rescues growth diminution of rice seedlings under salt stress.

  14. Piriformospora indica rescues growth diminution of rice seedlings during high salt stress

    Science.gov (United States)

    Jogawat, Abhimanyu; Saha, Shreya; Bakshi, Madhunita; Dayaman, Vikram; Kumar, Manoj; Dua, Meenakshi; Varma, Ajit; Oelmüller, Ralf; Tuteja, Narendra; Johri, Atul Kumar

    2013-01-01

    Piriformospora indica association has been reported to increase biotic as well as abiotic stress tolerance of its host plants. We analyzed the beneficial effect of P. indica association on rice seedlings during high salt stress conditions (200 and 300 mM NaCl). The growth parameters of rice seedlings such as root and shoot lengths or fresh and dry weights were found to be enhanced in P. indica-inoculated rice seedlings as compared with non-inoculated control seedlings, irrespective of whether they are exposed to salt stress or not. However, salt-stressed seedlings performed much better in the presence of the fungus compared with non-inoculated control seedlings. The photosynthetic pigment content [chlorophyll (Chl) a, Chl b, and carotenoids] was significantly higher in P. indica-inoculated rice seedlings under high salt stress conditions as compared with salt-treated non-inoculated rice seedlings, in which these pigments were found to be decreased. Proline accumulation was also observed during P. indica colonization, which may help the inoculated plants to become salt tolerant. Taken together, P. indica rescues growth diminution of rice seedlings under salt stress.

  15. My Car Is a Lemon! Use of the Better Business Bureau's Auto Line[R] Program as a Pedagogical Model of ADR

    Science.gov (United States)

    Steslow, Donna M.

    2010-01-01

    Alternative dispute resolution (ADR) is normally included as part of an introductory business law/legal environment course. While some business schools offer stand-alone ADR courses, the majority do not. As a result, a business student's only exposure to ADR processes may be through a Legal Studies in Business course. Several scholars have created…

  16. Arbitrage with ADRs: a sectorial case study for companies in Colombia, Mexico, Brazil and Chile Arbitraje con ADRs: un estudio de caso sectorial para empresas de Colombia, México, Brasil y Chile

    Directory of Open Access Journals (Sweden)

    Andrés Mauricio Mora

    2011-10-01

    Full Text Available This research continues the paper “Generalidades de los ADRs: Un estudio de casosectorial para empresas de Colombia, Mexico, Brasil y Chile” [ADRs generalities: a sectorial case study for companies in Colombia, Mexico, Brazil and Chile]. It is organizedin two sections. The first one covers the unique price theory and the efficient markets hypothesis. In the second one, arbitrage conditions with ADRs are empirically evaluated. The objective is to prove the existence of price differentials between stocks and ADRs, which would allow investors to obtain a risk free return.El presente artículo es la continuación del artículo “Generalidades de los ADRs: Un estudio de caso sectorial para empresas de Colombia, México, Brasil y Chile” y al igual que este, es un subproducto de la investigación “Arbitraje con ADRs: Un estudio de caso sectorial para empresas de Colombia, México, Brasil y Chile”. El artículo se divide en dos partes, en la primera se trata la teoría sobre la ley del precio único y la hipótesis de los mercados eficientes, y en la segunda parte se abarca el tema de arbitraje con activos financieros desde la práctica, haciendo un ejercicio econométrico de arbitraje con ADRs. El objetivo de esta investigación es comprobar la existencia de diferenciales de precio entre las acciones y sus respectivos ADRs, lo que permitiría a los inversionistas obtener una ganancia libre de riesgo.Abstract This research continues the paper “Generalidades de los ADRs: Un estudio de caso sectorial para empresas de Colombia, Mexico, Brasil y Chile” [ADRs generalities: a sectorial case study for companies in Colombia, Mexico, Brazil and Chile]. It is organized in two sections. The first one covers the unique price theory and the efficient markets hypothesis. In the second one, arbitrage conditions with ADRs are empirically evaluated. The objective is to prove the existence of price differentials between stocks and ADRs, which would allow

  17. Continuous cooling from 10 to 4 K using a toroidal ADR

    Energy Technology Data Exchange (ETDEWEB)

    DiPirro, Michael; Canavan, Edgar; Shirron, Peter; Tuttle, James [NASA/Goddard Space Flight Center, Code 552, Greenbelt, MD (United States)

    2004-08-01

    Future large infrared space telescopes will require cooling to 4 K to achieve background limited performance for submillimeter wavelengths. These observatories will require lifetimes of many years and will have relatively large cooling requirements making stored helium dewars impractical. We have designed and are building an adiabatic demagnetization refrigerator (ADR) for use in cooling relatively large loads (10-100 mW) at 4 K and rejecting that heat to a cryocooler operating at 10 K. The ADR magnet consists of eight short coils wired in series and arranged in a toroid to provide self shielding of its magnetic field. We will use gas gap heat switches to alternately connect the toroid to the cold load and the warm heat sink. A small continuous stage will maintain the cold end at 4 K while the main toroid is recycled. (Author)

  18. Active Debris Removal (ADR) System Architecture Analysis Tool (SAAT) Prototype for Orbital Debris Stabilization and Removal Architecture Development Project

    Data.gov (United States)

    National Aeronautics and Space Administration — It is critically important that a physics based ADR SAAT prototype be developed that can be refined and used across the community to study and analyze various remote...

  19. Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells

    Energy Technology Data Exchange (ETDEWEB)

    Yao, Jingyun; Wei, Xing [State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai (China); Shanghai Collaborative Innovation Center for Biomanufacturing Technology, 130 Meilong Road, Shanghai (China); Lu, Yanhua, E-mail: luyanhua@ecust.edu.cn [State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai (China); Shanghai Collaborative Innovation Center for Biomanufacturing Technology, 130 Meilong Road, Shanghai (China)

    2016-05-13

    Drug resistance limits leukemia treatment and chaetominine, a cytotoxic alkaloid that promotes apoptosis in a K562 human leukemia cell line via the mitochondrial pathway was studied with respect to chemoresistance in a K562/Adr human resistant leukemia cell line. Cytotoxicity assays indicated that K562/Adr resistance to adriamycin (ADR) did not occur in the presence of chaetominine and that chaetominine increased chemosensitivity of K562/Adr to ADR. Data show that chaetominine enhanced ADR-induced apoptosis and intracellular ADR accumulation in K562/Adr cells. Accordingly, chaetominine induced apoptosis by upregulating ROS, pro-apoptotic Bax and downregulating anti-apoptotic Bcl-2. RT-PCR and western-blot confirmed that chaetominine suppressed highly expressed MRP1 at mRNA and protein levels. But little obvious alternation of another drug transporter MDR1 mRNA was observed. Furthermore, inhibition of MRP1 by chaetominine relied on inhibiting Akt phosphorylation and nuclear Nrf2. In summary, chaetominine strongly reverses drug resistance by interfering with the PI3K/Akt/Nrf2 signaling, resulting in reduction of MRP1-mediated drug efflux and induction of Bax/Bcl-2-dependent apoptosis in an ADR-resistant K562/Adr leukemia cell line. - Highlights: • Chaetominine enhanced chemosensitivity of ADR against K562/Adr cells. • Chaetominine increased intracellular ADR levels via inhibiting MRP1. • Chaetominine induced apoptosis of K562/Adr cells through upregulation of ROS and modulation of Bax/Bcl-2. • Inhibition of MRP1 and Nrf2 by chaetominine treatment was correlative with blockade of PI3K/Akt signaling.

  20. Multiset proximity spaces

    Directory of Open Access Journals (Sweden)

    A. Kandil

    2016-10-01

    Full Text Available A multiset is a collection of objects in which repetition of elements is essential. This paper is an attempt to explore the theoretical aspects of multiset by extending the notions of compact, proximity relation and proximal neighborhood to the multiset context. Examples of new multiset topologies, open multiset cover, compact multiset and many identities involving the concept of multiset have been introduced. Further, an integral examples of multiset proximity relations are obtained. A multiset topology induced by a multiset proximity relation on a multiset M has been presented. Also the concept of multiset δ- neighborhood in the multiset proximity space which furnishes an alternative approach to the study of multiset proximity spaces has been mentioned. Finally, some results on this new approach have been obtained and one of the most important results is: every T4- multiset space is semi-compatible with multiset proximity relation δ on M (Theorem 5.10.

  1. Proximal Probes Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Proximal Probes Facility consists of laboratories for microscopy, spectroscopy, and probing of nanostructured materials and their functional properties. At the...

  2. Design of a 3-Stage ADR for the Soft X-Ray Spectrometer Instrument on the Astro-H Mission

    Science.gov (United States)

    Shirron, Peter J.; Kimball, Mark O.; Wegel, Donald C.; Canavan, Edgar R.; DiPirro, Michael J.

    2011-01-01

    The Japanese Astro-H mission will include the Soft X-ray Spectrometer (SXS) instrument, whose 36-pixel detector array of ultra-sensitive x-ray microcalorimeters requires cooling to 50 mK. This will be accomplished using a 3-stage adiabatic demagnetization refrigerator (ADR). The design is dictated by the need to operate with full redundancy with both a superfluid helium dewar at 1.3 K or below, and with a 4.5 K Joule-Thomson (JT) cooler. The ADR is configured as a 2-stage unit that is located in a well in the helium tank, and a third stage that is mounted to the top of the helium tank. The third stage is directly connected through two heat switches to the JT cooler and the helium tank, and manages heat flow between the two. When liquid helium is present, the 2-stage ADR operates in a single-shot manner using the superfluid helium as a heat sink. The third stage may be used independently to reduce the time-average heat load on the liquid to extend its lifetime. When the liquid is depleted, the 2nd and 3rd stages operate as a continuous ADR to maintain the helium tank at as low a temperature as possible - expected to be 1.2 K - and the 1st stage cools from that temperature as a single-stage, single-shot ADR. The ADR s design and operating modes are discussed, along with test results of the prototype 3-stage ADR.

  3. Ticlopidine safety profile: a case/non-case study on the basis of the spontaneous ADRs reporting in Italy.

    Science.gov (United States)

    Motola, Domenico; Biagi, Chiara; Leone, Roberto; Venegoni, Mauro; Lapi, Francesco; Cutroneo, Paola; Vargiu, Antonio; Bonaiuti, Roberto; Montanaro, Nicola; Vaccheri, Alberto

    2012-04-01

    INTRODUCTON: Ticlopidine is an antiplatelet agent available from several decades. Its most important adverse drug reactions (ADRs) involve haematological system. Our aim was to evaluate the safety profile of ticlopidine in the real life, on the basis of spontaneous ADR reporting. Spontaneous reports from 8 Italian Regions collected from 1990 to March 2007 were analysed. According to WHO Adverse Reaction Terminology for causality assessment only "certain", "probable" or "possible" ADRs were included. Association between drugs and any ADR was assessed by using the case/non-case methodoloy. Reporting odds ratio (ROR) was computed as a measure of disproportionality. Overall, 478 reports concerning ticlopidine were analysed. The system organ classes with significant disproportionality for ticlopidine included White Cell Disorders (ROR=22.43, 95% CI 18.54-27.12), Red Cell Disorders (8.22; 6.03-11.18), Liver And Biliary System (6.67; 5.35-8.32), Platelet, Bleeding & Clotting (6.59; 5.16-8.40). Fifteen percent of the ADRs occurred beyond the first three months of ticlopidine therapy. In 386 reports (80.7%), ticlopidine was the only suspected drug. Safety profile of ticlopidine can be considered well-established in terms of ADRs type but their frequency and severity continue to be higher in its current use. Since this drug is still widely used in Italy, both healthcare providers and patients should be aware of its ADRs. More specifically, patients should be regularly monitored during the whole period of use and not only in the first months of treatment.

  4. Causes of DMARD withdrawal following ADR within 6 months of initiation among Indian rheumatoid arthritis patients.

    Science.gov (United States)

    Mittal, Niti; Sharma, Aman; Jose, Vinu; Mittal, Rakesh; Wanchu, Ajay; Bambery, Pradeep

    2012-03-01

    The present study was conducted in Indian rheumatoid arthritis (RA) patients prescribed disease-modifying anti-rheumatic drugs (DMARDs) to determine the incidence and type of adverse drug reactions (ADRs) leading to their withdrawal in the initial 6 months of therapy. This was considered important as pharmacogenetic variations in the pattern of RA in different populations and genetic differences in efficacy and safety to drugs demand separate studies to be conducted in different populations. Hospital records were used to identify 1,000 consecutive patients with RA fulfilling the American College of Rheumatology criteria and having at least 6-month follow-up. Age, gender, duration of arthritis, drug usage and ADR-related drug withdrawal were recorded from the charts. Most of the patients were put on single DMARD. Combined use of DMARD was less frequent and non-use of DMARD was common; however, disease control was good. The commonest DMARD used in our hospital was hydroxychloroquine 444 (44%) and the commonest combination used was methotrexate with hydroxychloroquine by 55 (6%). Sulphasalazine use showed preference to young and males. Supportive drugs used were NSAIDs by 883 (88%), corticosteroids by 646 (65%), paracetamol by 594 (59%) and amitriptyline by 88 (9%). Incidence of ADR-related DMARD withdrawal was maximum with leflunomide 2/15 (13.33%) followed by methotrexate 9/116 (7.76%), sulphasalazine 6/185 (3.24%), chloroquine 3/131 (2.29%) and hydroxychloroquine 8/444 (1.8%). Severity and symptomatology of disease, genetic pattern of patients, financial status, previous experience of the clinicians and patients, availability of drugs, patient expectations and compliance were the main factors that lead to a difference in pattern of therapy in our patients compared to other population.

  5. ADR-IPO latinoamericanos registrados en la Bolsa de Comercio de Nueva York

    Directory of Open Access Journals (Sweden)

    Franco Parisi

    2008-01-01

    Full Text Available El objetivo de este trabajo es estudiar el desempeño de corto y largo plazo de los retornos accionarios de las empresas latinoamericanas que realizaron una oferta inicial de acciones (IPO por medio de American Depositary Receipts (ADR en la Bolsa de Comercio de Nueva York (NYSE. Los resultados señalan una subvaloración estadísticamente significativa de 9,22% para las ADR-IPOs que componen la cartera, y un rendimiento al finalizar el tercer año de 3,75%, estadísticamente significativo. Ambos comportamientos fueron confirmados por la metodología Block Bootstrap, y obtuvieron -en promedio- 11,33% para la subvaloración inicial y 3,92% para el tercer año posregistro. Estos resultados son esperados y de acuerdo a lo indicado por la bibliografía financiera internacional. Al estudiar estos activos latinoamericanos, comparando su rentabilidad con las carteras de mercado locales, la subvaloración inicial es de –0,51% y de 2,95% al cabo de tres años, ambos resultados no son estadísticamente significativos. Por lo anterior, los inversionistas estadounidenses son los que se ven más beneficiados con este tipo de emisión por sobre los inversionistas locales. Llama la atención que los ADR-IPOs no presenten un rendimiento anormal negativo al cabo de tres años de la emisión, hecho que es contrario a lo indicado por la bibliografía financiera.

  6. Educational intervention to improve physician reporting of adverse drug reactions (ADRs in a primary care setting in complementary and alternative medicine

    Directory of Open Access Journals (Sweden)

    Ostermann Thomas

    2009-07-01

    Full Text Available Abstract Background Recent studies have shown that adverse drug reactions (ADRs are underreported. This may be particularly true of ADRs associated with complementary and alternative medicine (CAM. Data on CAM-related ADRs, however, are sparse. Objective was to evaluate the impact of an educational intervention and monitoring programme designed to improve physician reporting of ADRs in a primary care setting. Methods A prospective multicentre study with 38 primary care practitioners specialized in CAM was conducted from January 2004 through June 2007. After 21 month all physicians received an educational intervention in terms of face-to-face training to assist them in classifying and reporting ADRs. The study centre monitored the quantity and quality of ADR reports and analysed the results. To measure changes in the ADR reporting rate, the median number of ADR reports and interquartile range (IQR were calculated before and after the educational intervention. The pre-intervention and post-intervention quality of the reports was assessed in terms of changes in the completeness of data provided for obligatory items. Interrater reliability between the physicians and the study centre was calculated using Cohen's kappa with a 95% confidence interval (CI. We used Mann Whitney U-test for testing continuous data and chi-square test was used for categorical data. The level of statistical significance was set at P Results A total of 404 ADRs were reported during the complete study period. An initial 148% increase (P = 0.001 in the number of ADR reports was observed after the educational intervention. Compared to baseline the postinterventional number of ADR reportings was statistically significant higher (P P Conclusion The results of the present study demonstrate that an educational intervention can increase physician awareness of ADRs. Participating physicians were able to incorporate the knowledge they had gained from face-to-face training into their

  7. Xanthohumol, a Prenylated Chalcone from Hops, Inhibits the Viability and Stemness of Doxorubicin-Resistant MCF-7/ADR Cells

    Directory of Open Access Journals (Sweden)

    Ming Liu

    2016-12-01

    Full Text Available Xanthohumol is a unique prenylated flavonoid in hops (Humulus lupulus L. and beer. Xanthohumol has been shown to possess a variety of pharmacological activities. There is little research on its effect on doxorubicin-resistant breast cancer cells (MCF-7/ADR and the cancer stem-like cells exiting in this cell line. In the present study, we investigate the effect of xanthohumol on the viability and stemness of MCF-7/ADR cells. Xanthohumol inhibits viability, induces apoptosis, and arrests the cell cycle of MCF-7/ADR cells in a dose-dependent manner; in addition, xanthohumol sensitizes the inhibition effect of doxorubicin on MCF-7/ADR cells. Interestingly, we also find that xanthohumol can reduce the stemness of MCF-7/ADR cells evidenced by the xanthohumol-induced decrease in the colony formation, the migration, the percentage of side population cells, the sphere formation, and the down-regulation of stemness-related biomarkers. These results demonstrate that xanthohumol is a promising compound targeting the doxorubicin resistant breast cancer cells and regulating their stemness, which, therefore, will be applied as a potential candidate for the development of a doxorubicin-resistant breast cancer agent and combination therapy of breast cancer.

  8. Thermodynamic Analysis of the 3-Stage ADR for the Astro-H Soft X-Ray Spectrometer Instrument

    Science.gov (United States)

    Shirron, Peter; Kimball, Mark; DiPirro, Michael; Bialas, Tom; Sneiderman, Gary; Porter, Scott; Kelley, Richard

    2015-01-01

    The Soft X-ray Spectrometer (SXS) instrument on Astro-H will use a 3-stage ADR to cool the microcalorimeter array to 50 mK. In the primary operating mode, two stages of the ADR cool the detectors using superfluid helium at 1.20 K as the heat sink. In the secondary mode, which is activated when the liquid helium is depleted, two of the stages continuously cool the (empty) helium tank using a 4.5 K Joule-Thomson cooler as the heat sink, and the third stage cools the detectors. In the design phase, a high-fidelity model of the ADR was developed in order to predict both the cooling capacity and heat rejection rates in both operating modes. The primary sources of heat flow are from the salt pills, hysteresis heat from the magnets and magnetic shields, and power dissipated by the heat switches. The flight instrument dewar, ADR, detectors and electronics were integrated in mid-2014 and have since undergone extensive performance testing, in part to validate the performance model. This paper will present the thermodynamic performance of the ADR, including cooling capacity, heat rejection to the heat sinks, and various measures of efficiency.

  9. Traceability of Biologics in The Netherlands: An Analysis of Information-Recording Systems in Clinical Practice and Spontaneous ADR Reports.

    Science.gov (United States)

    Klein, Kevin; Scholl, Joep H G; Vermeer, Niels S; Broekmans, André W; Van Puijenbroek, Eugène P; De Bruin, Marie L; Stolk, Pieter

    2016-02-01

    Pharmacovigilance requirements for biologics mandate that EU Member States shall ensure that any biologic that is the subject of a suspected adverse drug reaction (ADR) is identifiable by brand name and batch number. Recent studies showed that brand name identification is well established, whereas batch numbers are (still) poorly reported. We evaluated information-recording systems and practices in the Dutch hospital setting to identify determinants for brand name and batch number recording as well as success factors and bottlenecks for traceability. We surveyed Dutch hospital pharmacists with an online questionnaire on systems and practices in hospitals for recording brand names and batch numbers. Additionally, we performed an analysis of the traceability of recombinant biologics in spontaneous ADR reports (received between 2009 and 2014) from the Netherlands Pharmacovigilance Centre Lareb. The survey showed that brand names are not routinely recorded in the clinical practice of Dutch hospitals, whereas batch numbers are poorly recorded. Seventy-six percent of the 1523 ADR reports for recombinant biologics had a traceable brand name whereas 5% of these reports contained a batch number. The results suggest a possible relationship between the availability of brand and batch number information in clinical practice and the inclusion of this information in ADR reports for biologics. The limited traceability of brand names and batch numbers in ADR reports may be primarily caused by the shortcomings in the recording of information in clinical practice. We recommend efforts to improve information-recording systems as a first step to improve the traceability of biologics in ADR reporting.

  10. Estimation and diminution of CO2 emissions by clean development mechanism option at power sector in Oman

    Energy Technology Data Exchange (ETDEWEB)

    Singh Solanki, Parmal; Sarma Mallela, Venkateswara [Caledonian (University) College of Engineering, Muscat (Oman); Zhou, Chengke [Glasgow Caledonian University, Glasgow, Scotland (United Kingdom)

    2013-07-01

    Carbon dioxide (CO2) is one of the major pollutants among greenhouse gases emitted by fossil fuel based power plants and responsible for environmental tribulations. Therefore diminution of carbon dioxide level by Clean Development Mechanism (CDM) is now serious concern worldwide. This paper evaluates the emission factors of national electric grid in Oman and proposes a wind energy based CDM project to diminish the CO2 emissions. Estimations show that operating margin emission factors of national grid during five years lies in the range of 0.74 to 0.69 kg CO2/kWh. Further, proposed CDM project revealed the annual baseline emissions reduction of 45552 ton CO2 and able to earn the revenue of US$ 61.49 million by certify emission reductions in the first crediting period of project. Paper also critically analyse the opportunities for CDM project, its lucrative aspect, barrier and challenges.

  11. Operating Modes and Cooling Capabilities of the 3-Stage ADR Developed for the Soft-X-Ray Spectrometer Instrument on Astro-H

    Science.gov (United States)

    Shirron, Peter J.; Kimball, Mark O.; James, Bryan L.; Muench, Theo; DiPirro, Michael J.; Letmate, Richard V.; Sampson, Michael A.; Bialas, Tom G.; Sneiderman, Gary A.; Porter, Frederick S.; hide

    2015-01-01

    A 3-stage adiabatic demagnetization refrigerator (ADR) is used on the Soft X-ray Spectrometer instrument on Astro-H to cool a 6x6 array of x-ray microcalorimeters to 50 mK. The ADR is supported by a cryogenic system consisting of a superfluid helium tank, a 4.5 K Joule-Thomson (JT) cryocooler, and additional 2-stage Stirling cryocoolers that pre-cool the JT cooler and cool radiation shields within the cryostat. The ADR is configured so that it can use either the liquid helium or the JT cryocooler as its heat sink, giving the instrument an unusual degree of tolerance for component failures or degradation in the cryogenic system. The flight detector assembly, ADR and dewar were integrated into the flight dewar in early 2014, and have since been extensively characterized and calibrated. This paper summarizes the operation and performance of the ADR in all of its operating modes

  12. Traceability of Biologics in The Netherlands : An Analysis of Information-Recording Systems in Clinical Practice and Spontaneous ADR Reports

    NARCIS (Netherlands)

    Klein, Kevin; Scholl, Joep H G; Vermeer, Niels S; Broekmans, André W; Van Puijenbroek, Eugène P; De Bruin, Marie L; Stolk, Pieter

    INTRODUCTION AND OBJECTIVE: Pharmacovigilance requirements for biologics mandate that EU Member States shall ensure that any biologic that is the subject of a suspected adverse drug reaction (ADR) is identifiable by brand name and batch number. Recent studies showed that brand name identification is

  13. Capacitive proximity sensor

    Science.gov (United States)

    Kronberg, James W.

    1994-01-01

    A proximity sensor based on a closed field circuit. The circuit comprises a ring oscillator using a symmetrical array of plates that creates an oscillating displacement current. The displacement current varies as a function of the proximity of objects to the plate array. Preferably the plates are in the form of a group of three pair of symmetric plates having a common center, arranged in a hexagonal pattern with opposing plates linked as a pair. The sensor produces logic level pulses suitable for interfacing with a computer or process controller. The proximity sensor can be incorporated into a load cell, a differential pressure gauge, or a device for measuring the consistency of a characteristic of a material where a variation in the consistency causes the dielectric constant of the material to change.

  14. Neighborhoods and manageable proximity

    Directory of Open Access Journals (Sweden)

    Stavros Stavrides

    2011-08-01

    Full Text Available The theatricality of urban encounters is above all a theatricality of distances which allow for the encounter. The absolute “strangeness” of the crowd (Simmel 1997: 74 expressed, in its purest form, in the absolute proximity of a crowded subway train, does not generally allow for any movements of approach, but only for nervous hostile reactions and submissive hypnotic gestures. Neither forced intersections in the course of pedestrians or vehicles, nor the instantaneous crossing of distances by the technology of live broadcasting and remote control give birth to places of encounter. In the forced proximity of the metropolitan crowd which haunted the city of the 19th and 20th century, as well as in the forced proximity of the tele-presence which haunts the dystopic prospect of the future “omnipolis” (Virilio 1997: 74, the necessary distance, which is the stage of an encounter between different instances of otherness, is dissipated.

  15. Atrofia muscular proximal familiar

    Directory of Open Access Journals (Sweden)

    José Antonio Levy

    1962-09-01

    Full Text Available Os autores relatam dois casos de atrofia muscular proximal familiar, moléstia caracterizada por déficit motor e atrofias musculares de distribuição proximal, secundárias a lesão de neurônios periféricos. Assim, como em outros casos descritos na literatura, foi feito inicialmente o diagnóstico de distrofia muscular progressiva. O diagnóstico correto foi conseguido com auxílio da eletromiografia e da biopsia muscular.

  16. [Experimental proximal carpectomy. Biodynamics].

    Science.gov (United States)

    Kuhlmann, J N

    1992-01-01

    Proximal carpectomy was performed in 10 fresh cadavre wrists. Dynamic x-rays were taken and the forces necessary to obtain different movements before and after the operation were measured. Comparison of these parameters clearly defines the advantages and limitations of carpectomy and indicates the reasons.

  17. Proximate Analysis of Coal

    Science.gov (United States)

    Donahue, Craig J.; Rais, Elizabeth A.

    2009-01-01

    This lab experiment illustrates the use of thermogravimetric analysis (TGA) to perform proximate analysis on a series of coal samples of different rank. Peat and coke are also examined. A total of four exercises are described. These are dry exercises as students interpret previously recorded scans. The weight percent moisture, volatile matter,…

  18. Proximal Tibial Bone Graft

    Science.gov (United States)

    ... the Big Toe Ailments of the Smaller Toes Diabetic Foot Treatments Currently selected Injections and other Procedures Treatments ... from which the bone was taken if the foot/ankle surgeries done at the same time allow for it. ... problems after a PTBG include infection, fracture of the proximal tibia and pain related ...

  19. The extraordinary events of the major, sudden stratospheric warming, the diminutive antarctic ozone hole, and its split in 2002.

    Science.gov (United States)

    Varotsos, Costas

    2004-01-01

    Great interest in the unprecedented events of the major, sudden stratospheric warming and the ozone hole split over Antarctica in September 25, 2002 motivates a necessity to analyze the current understanding on the dynamics, chemistry and climate impacts that are associated with both events. Significant progress in the analysis of the observational data obtained, as well as successful development and application of dynamical modeling, which have been achieved very recently, create a basis for the first survey on the role of the major, sudden stratospheric warming observed in the southern hemisphere and its relationship to the diminutive Antarctic ozone hole and its break up into two parts. Special attention has been paid to assessments of the causes of the major warming event and the future expectations concerning the stratospheric ozone depletion effect. Among the principal results is the fact that, as the polar vortex elongated, it became hydrodynamically unstable, and this insta-, bility affected the upper troposphere and stratosphere. During the major, sudden stratospheric warming, the middle stratospheric vortex split into two pieces; one piece rapidly mixed with extra vortex air, while the other returned to the pole as a much weaker and smaller vortex. The polar night jet was considerably weaker than normal, and was displaced more poleward than has been observed in previous winters, resulting from a series of wave events (propagated from the troposphere) that took place over the course of the winter. Finally, the relative ozone decrease (increase) in the eastern Antarctic is tightly associated with westerly (easterly) zonal wind anomalies near the southern tip of South America, and the unusual behavior of the ozone hole in 2002 therefore appears to be caused by great easterlies in this region. The main conclusion is that the southern polar vortex and the diminutive ozone hole split into two parts in September 2002, due to the prevalence of very strong

  20. The GMRT 150 MHz all-sky radio survey. First alternative data release TGSS ADR1

    Science.gov (United States)

    Intema, H. T.; Jagannathan, P.; Mooley, K. P.; Frail, D. A.

    2017-02-01

    We present the first full release of a survey of the 150 MHz radio sky, observed with the Giant Metrewave Radio Telescope (GMRT) between April 2010 and March 2012 as part of the TIFR GMRT Sky Survey (TGSS) project. Aimed at producing a reliable compact source survey, our automated data reduction pipeline efficiently processed more than 2000 h of observations with minimal human interaction. Through application of innovative techniques such as image-based flagging, direction-dependent calibration of ionospheric phase errors, correcting for systematic offsets in antenna pointing, and improving the primary beam model, we created good quality images for over 95 percent of the 5336 pointings. Our data release covers 36 900 deg2 (or 3.6 π steradians) of the sky between -53° and +90° declination (Dec), which is 90 percent of the total sky. The majority of pointing images have a noise level below 5 mJy beam-1 with an approximate resolution of 25''×25'' (or 25''×25''/ cos(Dec-19°) for pointings south of 19° declination). We have produced a catalog of 0.62 Million radio sources derived from an initial, high reliability source extraction at the seven sigma level. For the bulk of the survey, the measured overall astrometric accuracy is better than two arcseconds in right ascension and declination, while the flux density accuracy is estimated at approximately ten percent. Within the scope of the TGSS alternative data release (TGSS ADR) project, the source catalog, as well as 5336 mosaic images (5°×5°) and an image cutout service, are made publicly available at the CDS as a service to the astronomical community. Next to enabling a wide range of different scientific investigations, we anticipate that these survey products will provide a solid reference for various new low-frequency radio aperture array telescopes (LOFAR, LWA, MWA, SKA-low), and can play an important role in characterizing the epoch-of-reionisation (EoR) foreground. The TGSS ADR project aims at

  1. OntoADR a semantic resource describing adverse drug reactions to support searching, coding, and information retrieval.

    Science.gov (United States)

    Souvignet, Julien; Declerck, Gunnar; Asfari, Hadyl; Jaulent, Marie-Christine; Bousquet, Cédric

    2016-10-01

    Efficient searching and coding in databases that use terminological resources requires that they support efficient data retrieval. The Medical Dictionary for Regulatory Activities (MedDRA) is a reference terminology for several countries and organizations to code adverse drug reactions (ADRs) for pharmacovigilance. Ontologies that are available in the medical domain provide several advantages such as reasoning to improve data retrieval. The field of pharmacovigilance does not yet benefit from a fully operational ontology to formally represent the MedDRA terms. Our objective was to build a semantic resource based on formal description logic to improve MedDRA term retrieval and aid the generation of on-demand custom groupings by appropriately and efficiently selecting terms: OntoADR. The method consists of the following steps: (1) mapping between MedDRA terms and SNOMED-CT, (2) generation of semantic definitions using semi-automatic methods, (3) storage of the resource and (4) manual curation by pharmacovigilance experts. We built a semantic resource for ADRs enabling a new type of semantics-based term search. OntoADR adds new search capabilities relative to previous approaches, overcoming the usual limitations of computation using lightweight description logic, such as the intractability of unions or negation queries, bringing it closer to user needs. Our automated approach for defining MedDRA terms enabled the association of at least one defining relationship with 67% of preferred terms. The curation work performed on our sample showed an error level of 14% for this automated approach. We tested OntoADR in practice, which allowed us to build custom groupings for several medical topics of interest. The methods we describe in this article could be adapted and extended to other terminologies which do not benefit from a formal semantic representation, thus enabling better data retrieval performance. Our custom groupings of MedDRA terms were used while performing signal

  2. Predicting the Risk of Adverse Drug Reactions in Older Inpatients: External Validation of the GerontoNet ADR Risk Score Using the CRIME Cohort.

    Science.gov (United States)

    Petrovic, Mirko; Tangiisuran, Balamurugan; Rajkumar, Chakravarthi; van der Cammen, Tischa; Onder, Graziano

    2017-02-01

    Adverse drug reactions (ADRs) in older people are often preventable, indicating that screening and prevention programs aimed at reducing their rate are needed in this population. The aim of this study was to externally validate the GerontoNet ADR risk score and to assess its validity in specific subpopulations of older inpatients. Data from the prospective CRIteria to assess appropriate Medication use among Elderly complex patients (CRIME) cohort were used. Dose-dependent and predictable ADRs were classified as type A, probable or definite ADRs were defined according to the Naranjo algorithm, and diagnostic accuracy was tested using receiver operating characteristic (ROC) analyses. Sensitivity and specificity were calculated for a cut-off point of 4. The mean age of the 1075 patients was 81.4 years (standard deviation 7.4) and the median number of drugs was 10 (range 7-13). At least one ADR was observed in 70 patients (6.5%); ADRs were classified as type A in 50 patients (4.7%) and defined as probable or definite in 41 patients (3.8%). Fair diagnostic accuracy to predict both type A and probable or definite ADRs was found in subpopulations aged 18.5 kg/m2) and a Mini-Mental State Examination (MMSE) score of >24/30 points, as well as in patients with osteoarthritis. The cut-off point of 4 points yielded very good sensitivity but poor specificity results in these subpopulations. This study suggests that the GerontoNet ADR risk score might represent a pragmatic approach to identifying specific subpopulations of older inpatients at increased risk of an ADR with a fair to good diagnostic accuracy.

  3. Proximal femoral fractures

    DEFF Research Database (Denmark)

    Palm, Henrik; Teixidor, Jordi

    2015-01-01

    -displaced femoral neck fractures and prosthesis for displaced among the elderly; and sliding hip screw for stabile- and intramedullary nails for unstable- and sub-trochanteric fractures) but they are based on a variety of criteria and definitions - and often leave wide space for the individual surgeons' subjective...... guidelines for hip fracture surgery and discuss a method for future pathway/guideline implementation and evaluation. METHODS: By a PubMed search in March 2015 six studies of surgical treatment pathways covering all types of proximal femoral fractures with publication after 1995 were identified. Also we...... searched the homepages of the national heath authorities and national orthopedic societies in West Europe and found 11 national or regional (in case of no national) guidelines including any type of proximal femoral fracture surgery. RESULTS: Pathway consensus is outspread (internal fixation for un...

  4. Proximal humeral fractures

    OpenAIRE

    Mauro, Craig S.

    2011-01-01

    Proximal humeral fractures may present with many different configurations in patients with varying co-morbities and expectations. As a result, the treating physician must understand the fracture pattern, the quality of the bone, other patient-related factors, and the expanding range of reconstructive options to achieve the best functional outcome and to minimize complications. Current treatment options range from non-operative treatment with physical therapy to fracture fixation using percuta...

  5. Development of a Space-Flight ADR Providing Continuous Cooling at 50 Mk with Heat Rejection at 10 K

    Science.gov (United States)

    Tuttle, James; Canavan, Edgar; DeLee, Hudson; DiPirro, Michael; Jahromi, Amir; James, Byron; Kimball, Mark; Shirron, Peter; Sullivan, Dan; Switzer, Eric

    2017-01-01

    Future astronomical instruments will require sub-Kelvin detector temperatures to obtain high sensitivity. In many cases large arrays of detectors will be used, and the associated cooling systems will need performance surpassing the limits of present technologies. NASA is developing a compact cooling system that will lift heat continuously at temperatures below 50 mK and reject it at over 10 K. Based on Adiabatic Demagnetization Refrigerators (ADRs), it will have high thermodynamic efficiency and vibration-free operation with no moving parts. It will provide more than 10 times the current flight ADR cooling power at 50 mK and will also continuously cool a 4 K stage for instruments and optics. In addition, it will include an advanced magnetic shield resulting in external field variations below 5 T. We describe the cooling system here and report on the progress in its development.

  6. PAEDIATRIC ADVERSE DRUG REACTIONS (ADRS): A COMPARISON OF A NEWLY DEVELOPED AVOIDABILITY TOOL TO EXISTING HALLAS ASSESSMENTS.

    Science.gov (United States)

    Bracken, Louise; Kirkham, Jamie; Nunn, Anthony; Pirmohamed, Munir; Peak, Matthew; Turner, Mark

    2016-09-01

    To compare a newly developed avoidability assessment tool (AAT) to existing Hallas assessments1 for a set of paediatric ADR cases. The new AAT was employed to assess 249 case reports of ADRs causing admission to hospital. The case reports contained a description of the ADR, details of suspected and concurrent medication and past medical history. Each case report was independently assessed and an avoidability category assigned. For ADRs categorised as either 'possibly' or 'definitely avoidable' a rationale was recorded. A second reviewer independently assessed a purposive sample (10%) for validation and quality assurance purposes.The final outcome was then compared to the Hallas assessments (1) previously completed as part of another study, which was carried out in a consensus group setting. Both tools used categorical scores with the same four point ordinal scale 'definitely avoidable', 'possibly avoidable', 'not avoidable' and 'unassessable'. Assessment of the 249 ADR case reports using the new AAT found that 19.3% were either possibly or definitely avoidable. This figure increased to almost 32% for the non-oncology cases (129/249) and decreased to 5.8% for the oncology cases (120/249). This was similar to the Hallas results (1), where overall, 22% of ADRs were deemed either possibly or definitely avoidable.Percentage exact agreement (%EA) was 90% overall; when subcategorised into oncology and non-oncology cases the %EA was found to be 94.2% and 86% respectively. Percentage extreme disagreement (%ED) was 0.8%. The kappa score was 0.71 (95% CI 0.60-0.82) for all cases, 0.54 (95% CI 0.40-0.68) for the oncology cases and 0.73 (95% CI 0.58-0.88) for the non-oncology cases. In total there were 25/249 cases with disagreement. %EA agreement from the validation check was 72%. Assessment with the new AAT showed that approximately 19% of all cases were either possibly or definitely avoidable. This was comparable to the Hallas assessments (1). The sub-categorisation of the

  7. Automated Price and Demand Response Demonstration for Large Customers in New York City using OpenADR

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Joyce Jihyun; Yin, Rongxin; Kiliccote, Sila

    2013-10-01

    Open Automated Demand Response (OpenADR), an XML-based information exchange model, is used to facilitate continuous price-responsive operation and demand response participation for large commercial buildings in New York who are subject to the default day-ahead hourly pricing. We summarize the existing demand response programs in New York and discuss OpenADR communication, prioritization of demand response signals, and control methods. Building energy simulation models are developed and field tests are conducted to evaluate continuous energy management and demand response capabilities of two commercial buildings in New York City. Preliminary results reveal that providing machine-readable prices to commercial buildings can facilitate both demand response participation and continuous energy cost savings. Hence, efforts should be made to develop more sophisticated algorithms for building control systems to minimize customer's utility bill based on price and reliability information from the electricity grid.

  8. Development of a quality instrument for assessing the spontaneous reports of ADR/ADE using Delphi method in China.

    Science.gov (United States)

    Chen, Lixun; Jiang, Ling; Shen, Aizong; Wei, Wei

    2016-09-01

    The frequently low quality of submitted spontaneous reports is of an increasing concern; to our knowledge, no validated instrument exists for assessing case reports' quality comprehensively enough. This work was conducted to develop such a quality instrument for assessing the spontaneous reports of adverse drug reaction (ADR)/adverse drug event (ADE) in China. Initial evaluation indicators were generated using systematic and literature data analysis. Final indicators and their weights were identified using Delphi method. The final quality instrument was developed by adopting the synthetic scoring method. A consensus was reached after four rounds of Delphi survey. The developed quality instrument consisted of 6 first-rank indicators, 18 second-rank indicators, and 115 third-rank indicators, and each rank indicator has been weighted. It evaluates the quality of spontaneous reports of ADR/ADE comprehensively and quantitatively on six parameters: authenticity, duplication, regulatory, completeness, vigilance level, and reporting time frame. The developed instrument was tested with good reliability and validity, which can be used to comprehensively and quantitatively assess the submitted spontaneous reports of ADR/ADE in China.

  9. New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse.

    Science.gov (United States)

    De Luca, Annamaria; Pierno, Sabata; Liantonio, Antonella; Desaphy, Jean-François; Natuzzi, Fedele; Didonna, Maria Paola; Ferrannini, Ermanno; Jockusch, Harald; Franchini, Carlo; Lentini, Giovanni; Corbo, Filomena; Tortorella, Vincenzo; Camerino, Diana Conte

    2004-07-01

    The antimyotonic activity of chiral derivatives of mexiletine and tocainide, selected as potent use-dependent blockers of skeletal muscle sodium channels, was evaluated in vivo acutely in myotonic ADR mice. The compounds had either aromatic (Me4 and Me6) or branched isopropyl groups (Me5 and To1) on the asymmetric centre, or had this latter one methylene apart from the amino group (Me2). Therapeutic doses of mexiletine (5-10 mg/kg) and tocainide (7-20 mg/kg) significantly reduced the long time of righting reflex (TRR), typical of ADR mice. Me4, Me5 and Me6 were 2-fold more potent than mexiletine. To1 fully normalised the TRR at 7 mg/kg. The electromyographic analysis confirmed a muscle-based activity for drug effectiveness on TRR. All the compounds reduced the myotonic hyperexcitability of intercostal muscle fibres when tested in vitro by current-clamp recordings, with a potency correlated with their action on sodium channels. On stimulus-evoked firing, the isopropyl analogues were 2-4-fold more potent than parent compounds, while the aromatic analogues were about 10-fold more potent than mexiletine. Patch-clamp recordings confirmed a normal-like pharmacological sensitivity of sodium channels of native ADR muscle fibres. Finally, the in vivo antimyotonic activity is due to the block of sodium channels and divergences with in vitro potency can be related to structure-based changes in drug pharmacokinetics.

  10. Real-time differentiation of adenomatous and hyperplastic diminutive colorectal polyps during analysis of unaltered videos of standard colonoscopy using a deep learning model.

    Science.gov (United States)

    Byrne, Michael F; Chapados, Nicolas; Soudan, Florian; Oertel, Clemens; Linares Pérez, Milagros; Kelly, Raymond; Iqbal, Nadeem; Chandelier, Florent; Rex, Douglas K

    2017-10-24

    In general, academic but not community endoscopists have demonstrated adequate endoscopic differentiation accuracy to make the 'resect and discard' paradigm for diminutive colorectal polyps workable. Computer analysis of video could potentially eliminate the obstacle of interobserver variability in endoscopic polyp interpretation and enable widespread acceptance of 'resect and discard'. We developed an artificial intelligence (AI) model for real-time assessment of endoscopic video images of colorectal polyps. A deep convolutional neural network model was used. Only narrow band imaging video frames were used, split equally between relevant multiclasses. Unaltered videos from routine exams not specifically designed or adapted for AI classification were used to train and validate the model. The model was tested on a separate series of 125 videos of consecutively encountered diminutive polyps that were proven to be adenomas or hyperplastic polyps. The AI model works with a confidence mechanism and did not generate sufficient confidence to predict the histology of 19 polyps in the test set, representing 15% of the polyps. For the remaining 106 diminutive polyps, the accuracy of the model was 94% (95% CI 86% to 97%), the sensitivity for identification of adenomas was 98% (95% CI 92% to 100%), specificity was 83% (95% CI 67% to 93%), negative predictive value 97% and positive predictive value 90%. An AI model trained on endoscopic video can differentiate diminutive adenomas from hyperplastic polyps with high accuracy. Additional study of this programme in a live patient clinical trial setting to address resect and discard is planned. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  11. 2009 Workshop International sobre ADR/ODR. Construir ponts: marc jurídic i principis

    Directory of Open Access Journals (Sweden)

    Aura Ester Vilalta

    2009-12-01

    Full Text Available Ressenya de la jornada que va tenir lloc el 15 de setembre de 2009, dedicada a l'anàlisi i sistematització dels principis i estàndards que regeixen les modalitats alternatives de resolució de conflictes (ADR/ODR i les particularitats que tenen, amb l'objectiu d'avançar en la delimitació del marc normatiu i la futura interoperativitat judicial d'aquestes modalitats.

  12. ASGE Technology Committee systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting real-time endoscopic assessment of the histology of diminutive colorectal polyps.

    Science.gov (United States)

    Abu Dayyeh, Barham K; Thosani, Nirav; Konda, Vani; Wallace, Michael B; Rex, Douglas K; Chauhan, Shailendra S; Hwang, Joo Ha; Komanduri, Sri; Manfredi, Michael; Maple, John T; Murad, Faris M; Siddiqui, Uzma D; Banerjee, Subhas

    2015-03-01

    In vivo real-time assessment of the histology of diminutive (≤5 mm) colorectal polyps detected at colonoscopy can be achieved by means of an "optical biopsy" by using currently available endoscopic technologies. This systematic review and meta-analysis was performed by the American Society for Gastrointestinal Endoscopy (ASGE) Technology Committee to specifically assess whether acceptable performance thresholds outlined by an ASGE Preservation and Incorporation of Valuable endoscopic Innovations (PIVI) document for clinical adoption of these technologies have been met. We conducted direct meta-analyses calculating the pooled negative predictive value (NPV) for narrow-band imaging (NBI), i-SCAN, and Fujinon Intelligent Color Enhancement (FICE)-assisted optical biopsy for predicting adenomatous polyp histology of small/diminutive colorectal polyps. We also calculated the pooled percentage agreement with histopathology when assigning postpolypectomy surveillance intervals based on combining real-time optical biopsy of colorectal polyps 5 mm or smaller with histopathologic assessment of polyps larger than 5 mm. Random-effects meta-analysis models were used. Statistical heterogeneity was evaluated by means of I(2) statistics. Our meta-analyses indicate that optical biopsy with NBI, exceeds the NPV threshold for adenomatous polyp histology, supporting a "diagnose-and-leave" strategy for diminutive predicted nonneoplastic polyps in the rectosigmoid colon. The pooled NPV of NBI for adenomatous polyp histology by using the random-effects model was 91% (95% confidence interval [CI], 88-94). This finding was associated with a high degree of heterogeneity (I(2) = 89%). Subgroup analysis indicated that the pooled NPV was greater than 90% for academic medical centers (91.8%; 95% CI, 89-94), for experts (93%; 95% CI, 91-96), and when the optical biopsy assessment was made with high confidence (93%; 95% CI, 90-96). Our meta-analyses also indicate that the agreement in

  13. Surface protein Adr2 of Rickettsia rickettsii induced protective immunity against Rocky Mountain spotted fever in C3H/HeN mice.

    Science.gov (United States)

    Gong, Wenping; Xiong, Xiaolu; Qi, Yong; Jiao, Jun; Duan, Changsong; Wen, Bohai

    2014-04-11

    Rickettsia rickettsii is the pathogen of Rocky Mountain spotted fever (RMSF), a life-threatening tick-transmitted infection. Adr2 was a surface-exposed adhesion protein of R. rickettsii and its immunoprotection against RMSF was investigated in mice. Recombinant Adr2 (rAdr2) was used to immunize C3H/HeN mice, and the rickettsial loads in organs of the mice were detected after challenge with R. rickettsii. The levels of specific antibodies of sera from the immunized mice were determined and the sera from immunized mice were applied to neutralize R. rickettsii. Proliferation and cytokine secretion of CD4(+) and CD8(+) T cells isolated from R. rickettsii-infected mice were also assayed after rAdr2 stimulation. After R. rickettsii challenge, the rickettsial loads in spleens, livers, and lungs were significantly lower and the impairment degrees of these organs in rAdr2-immunized mice were markedly slighter, compared with those in negative control mice. The ratio of specific IgG2a/IgG1 of rAdr2-immunized mice kept increasing during the immunization. After treatment with rAdr2-immunized sera, the total number of R. rickettsii organisms adhering and invading host cells was significantly lower than that treated with PBS-immunized sera. Interferon-γ secretion by CD4(+) or CD8(+) T cells and tumor necrosis factor-α secretion by CD4(+) T cells from R. rickettsii-infected mice were respectively significantly greater than those from uninfected mice after rAdr2 stimulation. Adr2 is a protective antigen of R. rickettsii. Protection offered by Adr2 is mainly dependent on antigen-specific cell-mediated immune responses, including efficient activity of CD4(+) and CD8(+) T cells to produce great amount of TNF-α and/or IFN-γ as well as rapid increase of specific IgG2a, which synergistically activate and opsonize host cells to killing intracellular rickettsiae. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Some Properties of Fuzzy Soft Proximity Spaces

    Science.gov (United States)

    Demir, İzzettin; Özbakır, Oya Bedre

    2015-01-01

    We study the fuzzy soft proximity spaces in Katsaras's sense. First, we show how a fuzzy soft topology is derived from a fuzzy soft proximity. Also, we define the notion of fuzzy soft δ-neighborhood in the fuzzy soft proximity space which offers an alternative approach to the study of fuzzy soft proximity spaces. Later, we obtain the initial fuzzy soft proximity determined by a family of fuzzy soft proximities. Finally, we investigate relationship between fuzzy soft proximities and proximities. PMID:25793224

  15. PROXIMITY MANAGEMENT IN CRISIS CONDITIONS

    Directory of Open Access Journals (Sweden)

    Ion Dorin BUMBENECI

    2010-01-01

    Full Text Available The purpose of this study is to evaluate the level of assimilation for the terms "Proximity Management" and "Proximity Manager", both in the specialized literature and in practice. The study has two parts: the theoretical research of the two terms, and an evaluation of the use of Proximity management in 32 companies in Gorj, Romania. The object of the evaluation resides in 27 companies with less than 50 employees and 5 companies with more than 50 employees.

  16. Demonstration of automated price response in large customers in New York City using Auto-DR and OpenADR

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Joyce Jihyun [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Schetrit, Oren [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Yin, Rongxin [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kiliccote, Sila [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2014-05-01

    Demand response (DR) – allowing customers to respond to reliability requests and market prices by changing electricity use from their normal consumption pattern – continues to be seen as an attractive means of demand-side management and a fundamental smart-grid improvement that links supply and demand. From October 2011 to December 2013, the Demand Response Research Center at Lawrence Berkeley National Laboratory, the New York State Energy Research and Development Authority, and partners Honeywell and Akuacom, have conducted a demonstration project enabling Automated Demand Response (Auto-DR) in large commercial buildings located in New York City using Open Automated Demand Response (OpenADR) communication protocols. In particular, this project focuses on demonstrating how the OpenADR platform, enabled by Akuacom, can automate and simplify interactions between buildings and various stakeholders in New York State and enable the automation of customers’ price response to yield bill savings under dynamic pricing. In this paper, the cost control opportunities under day-ahead hourly pricing and Auto-DR control strategies are presented for four demonstration buildings; present the breakdown of Auto-DR enablement costs; summarize the field test results and their load impact; and show potential bill savings by enabling automated price response under Consolidated Edison’s Mandatory Hourly Pricing (MHP) tariff. For one of the sites, the potential bill savings at the site’s current retail rate are shown. Facility managers were given granular equipment-level opt-out capability to ensure full control of the sites during the Auto-DR implementation. The expected bill savings ranged from 1.1% to 8.0% of the total MHP bill. The automation and enablement costs ranged from $70 to $725 per kW shed. The results show that OpenADR can facilitate the automation of price response, deliver savings to the customers and opt-out capability of the implementation retains control of the

  17. Operating Modes and Cooling Capabilities of the 3-Stage ADR Developed for the Soft-X-ray Spectrometer Instrument on Astro-H.

    Science.gov (United States)

    Shirron, Peter J; Kimball, Mark O; James, Bryan L; Muench, Theo; DiPirro, Michael J; Letmate, Richard V; Sampson, Michael A; Bialas, Tom G; Sneiderman, Gary A; Porter, Frederick S; Kelley, Richard L

    2016-03-01

    A 3-stage adiabatic demagnetization refrigerator (ADR)[1] is used on the Soft X-ray Spectrometer instrument[2] on Astro-H[3] to cool a 6×6 array of x-ray microcalorimeters to 50 mK. The ADR is supported by a cryogenic system[4] consisting of a superfluid helium tank, a 4.5 K Joule-Thomson (JT) cryocooler, and additional 2-stage Stirling cryocoolers that pre-cool the JT cooler and cool radiation shields within the cryostat. The ADR is configured so that it can use either the liquid helium or the JT cryocooler as its heat sink, giving the instrument an unusual degree of tolerance for component failures or degradation in the cryogenic system. The flight detector assembly, ADR and dewar were integrated into the flight dewar in early 2014, and have since been extensively characterized and calibrated. This paper summarizes the operation and performance of the ADR in all of its operating modes.

  18. TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease.

    Science.gov (United States)

    Pappu, Bhanu P; Borodovsky, Anna; Zheng, Timothy S; Yang, Xuexian; Wu, Ping; Dong, Xingwen; Weng, Shawn; Browning, Beth; Scott, Martin L; Ma, Li; Su, Lihe; Tian, Qiang; Schneider, Pascal; Flavell, Richard A; Dong, Chen; Burkly, Linda C

    2008-05-12

    T helper type 17 (Th17) cells play an important pathogenic function in autoimmune diseases; their regulation, however, is not well understood. We show that the expression of a tumor necrosis factor receptor family member, death receptor 3 (DR3; also known as TNFRSF25), is selectively elevated in Th17 cells, and that TL1A, its cognate ligand, can promote the proliferation of effector Th17 cells. To further investigate the role of the TL1A-DR3 pathway in Th17 regulation, we generated a TL1A-deficient mouse and found that TL1A(-/-) dendritic cells exhibited a reduced capacity in supporting Th17 differentiation and proliferation. Consistent with these data, TL1A(-/-) animals displayed decreased clinical severity in experimental autoimmune encephalomyelitis (EAE). Finally, we demonstrated that during EAE disease progression, TL1A was required for the optimal differentiation as well as effector function of Th17 cells. These observations thus establish an important role of the TL1A-DR3 pathway in promoting Th17 cell function and Th17-mediated autoimmune disease.

  19. Is it Code Imperfection or 'garbage in Garbage Out'? Outline of Experiences from a Comprehensive Adr Code Verification

    Science.gov (United States)

    Zamani, K.; Bombardelli, F. A.

    2013-12-01

    ADR equation describes many physical phenomena of interest in the field of water quality in natural streams and groundwater. In many cases such as: density driven flow, multiphase reactive transport, and sediment transport, either one or a number of terms in the ADR equation may become nonlinear. For that reason, numerical tools are the only practical choice to solve these PDEs. All numerical solvers developed for transport equation need to undergo code verification procedure before they are put in to practice. Code verification is a mathematical activity to uncover failures and check for rigorous discretization of PDEs and implementation of initial/boundary conditions. In the context computational PDE verification is not a well-defined procedure on a clear path. Thus, verification tests should be designed and implemented with in-depth knowledge of numerical algorithms and physics of the phenomena as well as mathematical behavior of the solution. Even test results need to be mathematically analyzed to distinguish between an inherent limitation of algorithm and a coding error. Therefore, it is well known that code verification is a state of the art, in which innovative methods and case-based tricks are very common. This study presents full verification of a general transport code. To that end, a complete test suite is designed to probe the ADR solver comprehensively and discover all possible imperfections. In this study we convey our experiences in finding several errors which were not detectable with routine verification techniques. We developed a test suit including hundreds of unit tests and system tests. The test package has gradual increment in complexity such that tests start from simple and increase to the most sophisticated level. Appropriate verification metrics are defined for the required capabilities of the solver as follows: mass conservation, convergence order, capabilities in handling stiff problems, nonnegative concentration, shape preservation, and

  20. O impacto da Lei Sarbanes-Oxley (SOX na qualidade do lucro das empresas brasileiras que emitiram ADRs The impact of Sarbanes-Oxley on earnings quality of Brazilian ADR issuers

    Directory of Open Access Journals (Sweden)

    Mark Miranda de Mendonça

    2010-01-01

    Full Text Available Este trabalho objetiva analisar o impacto da Lei Sarbanes-Oxley (SOX na qualidade do lucro das empresas brasileiras que emitiram ADR antes de 2002. Os escândalos contábeis de companhias como Enron e WorldCom reduziram a confiança dos investidores sobre a veracidade das demonstrações financeiras. A SOX surgiu com o propósito de proteger os investidores pela melhora na precisão e na confiabilidade na divulgação das demonstrações das empresas. Para medir a qualidade dos lucros, foram utilizados o Modelo de Basu (1997 e os modelos apresentados em Ball e Shivakumar (2005, estimados com dados em painel. Esperava-se que o aumento da regulamentação implicasse em maior grau de qualidade dos lucros nas empresas no período pós-SOX. Os resultados encontrados não são significativos nos modelos de Reversão à média das variações dos lucros e Cash Flow de Ball e Shivakumar (2005, mas os resultados do Modelo de Basu (1997 sugerem indício de aumento do conservadorismo contábil após a SOX, nas empresas brasileiras que emitiram ADR antes de 2002. Contudo, esse aumento do conservadorismo pelo Modelo de Basu (1997 também foi observado para todas as empresas brasileiras. Portanto, os resultados aqui apresentados sugerem indícios de aumento do conservadorismo brasileiro a partir de 2002, mas por outros motivos econômicos que não ocasionados pelo efeito SOX.This study analyzes the impact of the Sarbanes-Oxley Act (SOX on earnings quality of Brazilian companies qualified as ADR issuers before 2002. The accounting scandals involving firms like Enron and WorldCom reduced investors confidence in the reliability of financial statements. SOX arose to protect investors by mandating more precise and reliable financial disclosure by firms. To measure earnings quality, we used the models by Basu (1997 and Ball and Shivakumar (2005, estimated with panel data. We expected that the enhanced legal framework would imply greater earnings quality in the

  1. Fractures of the proximal humerus

    DEFF Research Database (Denmark)

    Brorson, Stig

    2013-01-01

    . The bandages were further supported by splints made of wood or coarse grass. Healing was expected in forty days. Different fracture patterns have been discussed and classified since Ancient Greece. Current classification of proximal humeral fractures mainly relies on the classifications proposed by Charles......, classification of proximal humeral fractures remains a challenge for the conduct, reporting, and interpretation of clinical trials. The evidence for the benefits of surgery in complex fractures of the proximal humerus is weak. In three systematic reviews I studied the outcome after locking plate osteosynthesis......Fractures of the proximal humerus have been diagnosed and managed since the earliest known surgical texts. For more than four millennia the preferred treatment was forceful traction, closed reduction, and immobilization with linen soaked in combinations of oil, honey, alum, wine, or cerate...

  2. The infrastructure of psychological proximity

    DEFF Research Database (Denmark)

    Nickelsen, Niels Christian Mossfeldt

    2015-01-01

    ). The experience of psychological proximity between patient and nurse is provided through confidence, continuity and the practical set-up. This constitutes an important enactment of skillfulness, which may render telemedicine a convincing health service in the future. Methodology: The study draws on a pilot...... (Langstrup & Winthereik 2008). This study contributes by showing the infrastructure of psychological proximity, which is provided by way of device, confidence, continuity and accountability....

  3. Targeting of Micelles and Liposomes Loaded with the Pro-Apoptotic Drug, NCL-240, into NCI/ADR-RES Cells in a 3D Spheroid Model.

    Science.gov (United States)

    Pattni, Bhushan S; Nagelli, Srikar G; Aryasomayajula, Bhawani; Deshpande, Pranali P; Kulkarni, Abhijit; Hartner, William C; Thakur, Ganesh; Degterev, Alexei; Torchilin, Vladimir P

    2016-10-01

    To develop transferrin (Tf)-targeted delivery systems for the pro-apoptotic drug, NCL-240, and to evaluate the efficacy of this delivery system in ovarian cancer NCI/ADR-RES cells, grown in vitro in a 3D spheroid model. Tf-targeted PEG-PE-based micellar and ePC/CHOL-based liposomal delivery systems for NCL-240 were prepared. NCI/ADR-RES cells were used to generate spheroids by a non-adhesive liquid overlay technique. Spheroid growth and development were monitored by size (diameter) analysis and H&E staining. The targeted formulations were compared to untargeted ones in terms of their degree of spheroid association and penetration. A cell viability analysis with NCL-240-loaded micelles and liposomes was performed to assess the effectiveness of Tf-targeting. Tf-targeted polymeric micelles and Tf-targeted liposomes loaded with NCL-240 were prepared. NCI/ADR-RES cells generated spheroids that demonstrated the presence of a distinct necrotic core along with proliferating cells in the spheroid periphery, partly mimicking in vivo tumors. The Tf-targeted micelles and liposomes had a deeper spheroid penetration as compared to the untargeted delivery systems. Cell viability studies using the spheroid model demonstrated that Tf-mediated targeting markedly improved the cytotoxicity profile of NCL-240. Transferrin targeting enhanced delivery and effectiveness of micelles and liposomes loaded with NCL-240 against NCI/ADR-RES cancer cells in a 3D spheroid model.

  4. Design and validation of an automated method to detect known adverse drug reactions in MEDLINE: A contribution from the EU-ADR project

    NARCIS (Netherlands)

    P. Avillach (Paul); J.-C. Dufour (Jean-Charles); G. Diallo (Gayo); F. Salvo (Francesco); B.R. Joubert (Bonnie); F. Thiessard (Frantz); F. Mougin (Fleur); G. Trifirò (Gianluca); A. Fourrier-Reglat (Annie); A. Pariente (Antoine); M. Fieschi (Marius)

    2013-01-01

    textabstractObjectives: The aim of this research was to automate the search of publications concerning adverse drug reactions (ADR) by defining the queries used to search MEDLINE and by determining the required threshold for the number of extracted publications to confirm the drug/event association

  5. Categorias de Riscos Evidenciadas nos Relatórios da Administração de Empresas Brasileiras com ADRsRisk Categories Disclosed in the Administration Reports of Brazilian Companies with ADRsCategorías de Riesgos Constatadas en los Informes de Administración de Empresas Brasileñas con ADRs

    Directory of Open Access Journals (Sweden)

    ZONATTO, Vinícius Costa da Silva

    2010-06-01

    Full Text Available RESUMOO estudo objetiva identificar as categorias de riscos evidenciadas no Relatório da Administração (RA, relativa ao ano de 2007, das empresas brasileiras com emissão de American Depositary Receipt (ADRs. A pesquisa caracteriza-se como descritiva, realizada por meio de análise documental. A amostra compreende 28 empresas brasileiras com emissão de ADRs na Bolsa de Valores de Nova Iorque (EUA. Consideraram-se sete categorias de riscos corporativos, identificadas a partir da metodologia do Committee of Sponsoring Organizations of the Treadway Commission (COSO, 2004: riscos estratégicos, riscos de mercado, riscos de crédito, riscos de liquidez, riscos operacionais, riscos legais e riscos de imagem. Os resultados da pesquisa mostram que, em geral, não há uma padronização quanto aos tipos de riscos evidenciados pelas empresas. Ao todo foram identificados 14 tipos de riscos. A categoria predominante na evidenciação foi risco operacional, com 20,72% das observações. Não foi encontrada evidenciação de riscos de imagem nos RA das empresas pesquisadas. Constatou-se que 19 empresas evidenciam algum tipo de risco a que a empresa está exposta, o que representa 67,86% da amostra. Por outro lado, nove empresas (32,14% não evidenciaram nenhum tipo de risco.ABSTRACTThe study aims to find the categories of risks disclosed in the Administration Reports of Brazilian companies with the issuance of ADR's. The research is characterized as descriptive, accomplished through documentary analysis. The sample includes 28 Brazilian companies with the issuance of American Depositary Receipt (ADR's in the Stock Exchange of New York (USA. We have tried to identify the categories of risk, presented by the companies surveyed in the Administration Reports (AR of 2007. Seven categories of corporate risks were considered, identified through COSO (2004 methodology: strategic risks, market risks, credit risks, liquidity risks, operational risks, legal risks

  6. Cubesat Proximity Operations Demonstration (CPOD)

    Science.gov (United States)

    Villa, Marco; Martinez, Andres; Petro, Andrew

    2015-01-01

    The CubeSat Proximity Operations Demonstration (CPOD) project will demonstrate rendezvous, proximity operations and docking (RPOD) using two 3-unit (3U) CubeSats. Each CubeSat is a satellite with the dimensions 4 inches x 4 inches x 13 inches (10 centimeters x 10 centimeters x 33 centimeters) and weighing approximately 11 pounds (5 kilograms). This flight demonstration will validate and characterize many new miniature low-power proximity operations technologies applicable to future missions. This mission will advance the state of the art in nanosatellite attitude determination,navigation and control systems, in addition to demonstrating relative navigation capabilities.The two CPOD satellites are scheduled to be launched together to low-Earth orbit no earlier than Dec. 1, 2015.

  7. SHORT COMMUNICATION PROXIMATE COMPOSITION, MINERAL ...

    African Journals Online (AJOL)

    Preferred Customer

    SHORT COMMUNICATION. PROXIMATE COMPOSITION, MINERAL CONTENT AND ANTINUTRITIONAL. FACTORS OF SOME CAPSICUM (Capsicum annum) VARIETIES GROWN IN. ETHIOPIA. Esayas K.1, Shimelis A.2, Ashebir F.3, Negussie R.3, Tilahun B.4 and Gulelat D.4*. 1Hawassa University, Department of Food ...

  8. DNH 109: A fragmentary hominin near-proximal ulna from Drimolen, South Africa

    Directory of Open Access Journals (Sweden)

    Andrew Gallagher

    2011-05-01

    Full Text Available We describe a fragmentary, yet significant, diminutive proximal ulna (DNH 109 from the Lower Pleistocene deposits of Drimolen, Republic of South Africa. On the basis of observable morphology and available comparative metrics, DNH 109 is definitively hominin and is the smallest African Plio-Pleistocene australopith ulna yet recovered. Mediolateral and anteroposterior dimensions of the proximal diaphysis immediately distal to the m. brachialis sulcus in DNH 109 yield an elliptical area (π/4 *m-l*a-p that is smaller than the A.L. 333-38 Australopithecus afarensis subadult from Hadar. Given the unusually broad mediolateral/anteroposterior diaphyseal proportions distal to the brachialis sulcus, the osseous development of the medial and lateral borders of the sulcus, and the overall size of the specimen relative to comparative infant, juvenile, subadult and adult comparative hominid ulnae (Gorilla, Pan and Homo, it is probable that DNH 109 samples an australopith of probable juvenile age at death. As a result of the fragmentary state of preservation and absence of association with taxonomically diagnostic craniodental remains, DNH 109 cannot be provisionally assigned to any particular hominin genus (Paranthropus or Homo at present. Nonetheless, DNH 109 increases our known sample of available Plio-Pleistocene subadult early hominin postcrania.

  9. Diseño, cálculo, fabricación y evaluación de la conformidad (marcado CE) de un cisterna destinada al transporte de propano según ADR 2014

    OpenAIRE

    Rey Martín, José Álvaro del

    2014-01-01

    El objeto de este proyecto es el del diseño, cálculo y fabricación de una cisterna de gran capacidad de carga, destinada a transportar propano por carretera, cumpliendo con el marcado CE y con las exigencias del ADR 2014 (Acuerdo Europeo sobre el transporte internacional de cargas peligrosas por vía terrestre). En caso de no estar especificado en el ADR, se regirá por las normas UNE-EN garantizando el marcado CE. Prevalecerá lo expuesto en el ADR ante cualquier otra norma. Al cump...

  10. Qualification campaign of the 50 mK hybrid sorption-ADR cooler for SPICA/SAFARI

    Science.gov (United States)

    Duval, J.-M.; Duband, L.; Attard, A.

    2015-12-01

    SAFARI (SpicA FAR-infrared Instrument) is an infrared instrument planned to be part of the SPICA (SPace Infrared telescope for Cosmology and Astrophysics) Satellite. It will offer high spectral resolution in the 30 - 210 μm frequency range. SAFARI will benefit from the cold telescope of SPICA and to obtain the required detectors sensitivity, a temperature of 50 mK is required. This temperature is reached thanks to the use of a hybrid sorption - ADR (Adiabatic Demagnetization Refrigerator) cooler presented here. This cooler provides respectively 14 μW and 0.4 μW of cooling power at 300 mK and 50 mK. The cooler is planned to advantageously use two thermal interfaces of the instrument at 1.8 and 4.9 K. One of the challenges discussed in this paper is the low power available at each intercept. A dedicated laboratory electronic is being designed based on previous development with a particular focus on the 50 mK readout. Temperature regulation at 50 mK is also discussed. This cooler has been designed following flight constraints and will reach a high TRL, including mechanical and environmental tests at the end of the on-going qualification campaign.

  11. Photoactivated In Vivo Proximity Labeling.

    Science.gov (United States)

    Beck, David B; Bonasio, Roberto

    2017-06-19

    Identification of molecular interactions is paramount to understanding how cells function. Most available technologies rely on co-purification of a protein of interest and its binding partners. Therefore, they are limited in their ability to detect low-affinity interactions and cannot be applied to proteins that localize to difficult-to-solubilize cellular compartments. In vivo proximity labeling (IPL) overcomes these obstacles by covalently tagging proteins and RNAs based on their proximity in vivo to a protein of interest. In IPL, a heterobifunctional probe comprising a photoactivatable moiety and biotin is recruited by a monomeric streptavidin tag fused to a protein of interest. Following UV irradiation, candidate interacting proteins and RNAs are covalently biotinylated with tight spatial and temporal control and subsequently recovered using biotin as an affinity handle. Here, we describe experimental protocols to discover novel protein-protein and protein-RNA interactions using IPL. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley & Sons, Inc.

  12. Development of a space-flight ADR providing continuous cooling at 50 mK with heat rejection at 10 K

    Science.gov (United States)

    Tuttle, James; Canavan, Edgar; DeLee, Hudson; DiPirro, Michael; Jahromi, Amir; James, Bryan; Kimball, Mark; Shirron, Peter; Sullivan, Dan; Switzer, Eric

    2017-12-01

    Future astronomical instruments will require sub-Kelvin detector temperatures to obtain high sensitivity. In many cases large arrays of detectors will be used, and the associated cooling systems will need performance surpassing the limits of present technologies. NASA is developing a compact cooling system that will lift heat continuously at temperatures below 50 mK and reject it at over 10 K. Based on adiabatic demagnetization refrigerators (ADRs), it will have high thermodynamic efficiency and vibration-free operation with no moving parts. It will provide more than 10 times the current flight ADR cooling power at 50 mK and will also continuously cool a 4 K stage for instruments and optics. In addition, it will include an advanced magnetic shield resulting in external field variations below 5 μT. We describe the cooling system here and report on the progress in its development.

  13. Prox-1 Automated Proximity Operations

    Science.gov (United States)

    2016-01-13

    on demonstrating the functionality required to meet minimum mission success criteria. The minimum mission includes on- orbit spacecraft checkout of...also includes deployment of LightSail-B from the P-POD, and imaging of LightSail-B for 20 minutes as it recedes from Prox-1. small satellite ; proximity...criteria. The minimum mission includes on- orbit spacecraft checkout of all spacecraft subsystems, including flight qualification of the following new

  14. Knowledge and attitudes of HIV-infected patients on antiretroviral therapy regarding adverse drug reactions (ADRs in selected hospitals in Nigeria

    Directory of Open Access Journals (Sweden)

    Kenneth Anene Agu

    2012-01-01

    Full Text Available Purpose: The study evaluated the knowledge and attitudes of HIV-infected patients on ART regarding ADRs following routine patient counseling and education in selected hospitals in Nigeria. Materials and Methods: From 36,459 HIV-infected patients on ART in the 36 selected hospitals, a study-specific instrument was administered to 3,650 patients in a cross-sectional study. Patients were provided counseling and education on ADRs before and after commencing ART. Factor analysis was performed using principal components extraction. Item score means above midpoint (3.7 on a 5-point scale were regarded as positive attitudes and below as negative attitudes. A chi-square test was used for inferential statistics; P3.7 which denotes positive attitudes to ADRs. Three extracted factors accounted for 73.1% of cumulative variability. All attitude items had very significant loadings of ≥0.5. Conclusion: Overall, participants reported good knowledge and positive attitudes to adverse effects of their medicines compared to what was reported previously. The patient counseling and education on drug therapy provided to patients may have contributed to these findings and are highly recommended.

  15. PROXIMATE AND ELEMENTAL COMPOSITION OF WHITE GRUBS

    African Journals Online (AJOL)

    DR. AMINU

    PROXIMATE AND ELEMENTAL COMPOSITION OF WHITE GRUBS. 1 Alhassan, A. J. 1M .S. Sule, 1J. ... ABSTRACT. This study determined the proximate and mineral element composition of whole white grubs using standard methods of analysis. Proximate ... days, before pulverized to powder and kept in plastic container.

  16. Finger Proximal Interphalangeal Joint Dislocation.

    Science.gov (United States)

    Ramponi, Denise; Cerepani, Mary Jo

    2015-01-01

    Finger dislocations are common injuries that are often managed by emergency nurse practitioners. A systematic physical examination following these injuries is imperative to avoid complications. Radiographic views, including the anteroposterior, lateral, and oblique views, are imperative to evaluate these finger dislocations. A dorsal dislocation of the proximal interphalangeal (PIP) joint is the most common finger dislocation type often easily reduced. A volar PIP dislocation can often be difficult to reduce and may result in finger deformity. Finger dislocations should be reduced promptly. Referral to an orthopedic hand specialist is required if the dislocation is unable to be reduced or if the finger joint is unstable following reduction attempts.

  17. Equilibrium properties of proximity effect

    Energy Technology Data Exchange (ETDEWEB)

    Esteve, D.; Pothier, H.; Gueron, S.; Birge, N.O.; Devoret, M.

    1996-12-31

    The proximity effect in diffusive normal-superconducting (NS) nano-structures is described by the Usadel equations for the electron pair correlations. We show that these equations obey a variational principle with a potential which generalizes the Ginzburg-Landau energy functional. We discuss simple examples of NS circuits using this formalism. In order to test the theoretical predictions of the Usadel equations, we have measured the density of states as a function of energy on a long N wire in contact with a S wire at one end, at different distances from the NS interface. (authors). 12 refs.

  18. Laju Penurunan Logam Berat Plumbum (Pb) Dan Cadmium (Cd) Oleh Eichornia Crassipes Dan Cyperus Papyrus (the Diminution Rate of Heavy Metals, Plumbum and Cadmium by Eichornia Crassipes and Cyperus)

    OpenAIRE

    Tosepu, Ramadhan

    2012-01-01

    The aim of the study was to analyze the diminution rate of heavy metals, plumbum and cadmium by Eichornia crassipes and Cyperus papyrus and to compare the rate of their decrease. The study conducted in Makassar city by examining the water sample in the Brackish Water Culture Fishery Research in Maros. The data were analyzed statistically by employing T test and Post Hoc test. The results of the study indicate that the concentration of heavy metal, plumbum is quicker by using Eichornia crassi...

  19. Complications in proximal humeral fractures.

    Science.gov (United States)

    Calori, Giorgio Maria; Colombo, Massimiliano; Bucci, Miguel Simon; Fadigati, Piero; Colombo, Alessandra Ines Maria; Mazzola, Simone; Cefalo, Vittorio; Mazza, Emilio

    2016-10-01

    Necrosis of the humeral head, infections and non-unions are among the most dangerous and difficult-to-treat complications of proximal humeral fractures. The aim of this work was to analyse in detail non-unions and post-traumatic bone defects and to suggest an algorithm of care. Treatment options are based not only on the radiological frame, but also according to a detailed analysis of the patient, who is classified using a risk factor analysis. This method enables the surgeon to choose the most suitable treatment for the patient, thereby facilitating return of function in the shortest possible time. The treatment of such serious complications requires the surgeon to be knowledgeable about the following possible solutions: increased mechanical stability; biological stimulation; and reconstructive techniques in two steps, with application of biotechnologies and prosthetic substitution. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Rare-Earth Garnets and Perovskites for Space-Based ADR Cooling at High T and Low H

    Science.gov (United States)

    King, T. T.; Rowlett, B. A.; Ramirez, R. A.; Shirron, P. J.; Canavan, E. R.; DiPirro, M. J.; Panek, J. S.; Tuttle, J. G.; Shull, R. D.; Fry, R. A.; hide

    2001-01-01

    Future NASA satellite detector systems must be cooled to the 0.1 K temperature range to meet the stringent energy resolution and sensitivity requirements demanded by mid-term astronomy missions. The development of adiabatic demagnetization refrigeration (ADR) materials that can efficiently cool from the passive radiative cooling limit of approx. 30 K down to sub-Kelvin under low magnetic fields (H less than or equal to 3 T) would represent a significant improvement in space-based cooling technology. Governed by these engineering goals, our efforts have focused on quantifying the change in magnetic entropy of rare-earth garnets and perovskites. Various compositions within the gadolinium gallium iron garnet solid solution series (GGIG, Gd3Ga(5-x)Fe(x)O12, 0.00 less than or equal to X less than or equal to 5.00) and gadolinium aluminum perovskite (GAP, GdAlO3) have been synthesized via an organometallic complex approach and confirmed with powder x-ray diffraction. The magnetization of the GGIG and GAP materials has been measured as a function of composition (0.00 less than or equal to X less than or equal to 5.00), temperature (2 K less than or equal to T less than or equal to 30 K) and applied magnetic field (0 T less than or equal to H less than or equal to 3 T). The magnetic entropy change (DeltaS(sub mag)) between 0 T and 3 T was determined from the magnetization data. In the GGIG system, DeltaS(sub mag) was compositionally dependent; Fe(sup 3+) additions up to X less than or equal to 2.44 increased DeltaS(sub mag) at T > 5 K. For GAP, DeltaS(sub mag) was similar to that of GGIG, X = 0.00, both in terms of magnitude and temperature dependence at T > 10 K. However, the DeltaS(sub mag) of GAP at T < 10 K was less than the endmember GGIG composition, X = 0.00, and exhibited maximum approx. 5 K.

  1. Data Extraction and Management in Networks of Observational Health Care Databases for Scientific Research: A Comparison of EU-ADR, OMOP, Mini-Sentinel and MATRICE Strategies.

    Science.gov (United States)

    Gini, Rosa; Schuemie, Martijn; Brown, Jeffrey; Ryan, Patrick; Vacchi, Edoardo; Coppola, Massimo; Cazzola, Walter; Coloma, Preciosa; Berni, Roberto; Diallo, Gayo; Oliveira, José Luis; Avillach, Paul; Trifirò, Gianluca; Rijnbeek, Peter; Bellentani, Mariadonata; van Der Lei, Johan; Klazinga, Niek; Sturkenboom, Miriam

    2016-01-01

    We see increased use of existing observational data in order to achieve fast and transparent production of empirical evidence in health care research. Multiple databases are often used to increase power, to assess rare exposures or outcomes, or to study diverse populations. For privacy and sociological reasons, original data on individual subjects can't be shared, requiring a distributed network approach where data processing is performed prior to data sharing. We created a conceptual framework distinguishing three steps in local data processing: (1) data reorganization into a data structure common across the network; (2) derivation of study variables not present in original data; and (3) application of study design to transform longitudinal data into aggregated data sets for statistical analysis. We applied this framework to four case studies to identify similarities and differences in the United States and Europe: Exploring and Understanding Adverse Drug Reactions by Integrative Mining of Clinical Records and Biomedical Knowledge (EU-ADR), Observational Medical Outcomes Partnership (OMOP), the Food and Drug Administration's (FDA's) Mini-Sentinel, and the Italian network-the Integration of Content Management Information on the Territory of Patients with Complex Diseases or with Chronic Conditions (MATRICE). National networks (OMOP, Mini-Sentinel, MATRICE) all adopted shared procedures for local data reorganization. The multinational EU-ADR network needed locally defined procedures to reorganize its heterogeneous data into a common structure. Derivation of new data elements was centrally defined in all networks but the procedure was not shared in EU-ADR. Application of study design was a common and shared procedure in all the case studies. Computer procedures were embodied in different programming languages, including SAS, R, SQL, Java, and C++. Using our conceptual framework we found several areas that would benefit from research to identify optimal standards for

  2. Proximity sensor technology for manipulator end effectors

    Science.gov (United States)

    Johnston, A. R.

    1975-01-01

    Optical proximity sensing techniques which could be used to help control the critical grasping phase of a remote manipulation are described. The proximity sensors described use a triangulation geometry to detect a surface located in a pre-determined region. The design of the proximity sensors themselves is discussed, as well as their application to manipulator control with a local control loop, and possibilities for future development are discussed.

  3. Els ADR, procediments extrajudicials de resolució de conflictes: Legislació vigent i aplicació pràctica als conflictes empresarials

    OpenAIRE

    Casulleras Climent, Francesc

    2016-01-01

    En el present estudi s'analitzen els principals procediments extrajudicials de resolució de conflictes, anomenats ADR per les seves sigles en anglès (Alternative Dispute Resolution), o MASC per les sigles en castellà (Medios Alternativos de Solución de Conflictos), com son la mediació, l'arbitratge i la conciliació; es fa una anàlisi jurídica de la legislació vigent de cadascuna d¿aquestes modalitats, i s'analitza la seva aplicació pràctica en els conflictes empresarials. En el prese...

  4. Identification and characterization of microRNAs expressed in human breast cancer chemo-resistant MCF-7/Adr cells by Solexa deep-sequencing technology.

    Science.gov (United States)

    Xu, Pengfei; Wang, Luyu; Huang, Lei; Li, Wenqu; Lv, Shanshan; Lv, Mingming; Ma, Jingjing; Zhou, Qian; Wu, Xiaowei; Fu, Ziyi; Lu, Cheng; Yin, Hong

    2015-10-01

    Breast cancer is the most common type of tumor in female and chemoresistance has been a major clinical obstacle to the treatment in clinical patients. miRNA was one of the factors demonstrated to play certain roles in chemoesistance in breast cancer. In this study, we exploited Solexa deep sequencing technology to identify differentially expressed miRNA from samples in vitro, trying to find novel relationship between miRNA and chemoresistance in breast cancer. The human breast cancer MCF-7 cell line was pulse-selected with doxorubicin (10 pulses, once a week for 4h, with 1μM doxorubicin) to generate MCF-7/Adr cells. Total RNA was extracted from the treated and untreated MCF-7 cells and subsequently subjected to real time PCR. Two small RNA libraries of MCF7NON and MCF7ADR were established to record the Solexa sequencing results of the PCR products above. All the sequencing results were verified by Stem-loop real-time PCR. GO annotation and KEGG analysis program were exploited to enrich the differentially expressed miRNAs. The results showed that 214,822 and 378,597 reads were mapped in the MCF7ADR and MCF7NON libraries when aligned to hairpin structure respectively. Meanwhile, 1323 and 520 reads were mapped when aligned to mature sequences. In addition, 310 known mature miRNAs were coexpressed in both libraries. Comparing the MCF7ADR group to the MCF7NON group, 18 miRNAs were significantly differentially expressed. GO annotation and KEGG analysis showed that the target genes were enriched in regulation of transcription and development as well as Wnt signaling pathway, MAPK signaling pathway and TGF-ß signaling pathway. The results proved that the Solexa deep sequencing was a powerful and reliable platform to analyze small RNAs. And further investigation should be conducted for the biological process and pathways that have been identified and more efforts should be made to research the mechanism of chemoresistance in breast cancer. Copyright © 2015. Published by

  5. Proximate composition and antinutrient content of pumpkin ...

    African Journals Online (AJOL)

    Proximate composition and antinutrient content of pumpkin ( Cucurbita pepo ) and sorghum ( Sorghum bicolor ) flour blends fermented with Lactobacillus plantarum , Aspergillus niger and Bacillus subtilis.

  6. Functional outcome following proximal humeral interlocking system plating for displaced proximal humeral fractures

    OpenAIRE

    Thyagarajan David; Haridas Samarth; Jones Denise; Dent Colin; Evans Richard; Williams Rhys

    2009-01-01

    Aim: To assess the functional outcome following internal fixation with the PHILOS (proximal humeral interlocking system) for displaced proximal humeral fractures. Patients and Methods: We reviewed 30 consecutive patients treated surgically with the proximal humeral locking plate for a displaced proximal humeral fracture. Functional outcome was determined using the American Shoulder and Elbow Society (ASES) score and Constant Murley score. Results: Average age of the patients was 58 years...

  7. Best Proximity Points for a New Class of Generalized Proximal Mappings

    Directory of Open Access Journals (Sweden)

    Tayyab Kamran

    2017-03-01

    Full Text Available The best proximity points are usually used to find the optimal approximate solution of the operator equation Tx = x, when T has no fixed point. In this paper, we prove some best proximity point theorems for nonself multivalued operators, following the foot steps of Basha and Shahzad [Best proximity point theorems for generalized proximal contractions, Fixed Point Theory Appl., 2012, 2012:42].

  8. Preliminary phytochemical screening, proximate and elemental ...

    African Journals Online (AJOL)

    The seed powder of Moringa oleifera was analysed for its phytochemical, proximate and elemental composition using Folin-Denis spectrophotometric method, gravimetric method and energy dispersing X-ray fluorescence (EDXRF) transmission emission technique respectively. The seed powder had the following proximate ...

  9. Bimalleolar ankle fracture with proximal fibular fracture

    NARCIS (Netherlands)

    Colenbrander, R. J.; Struijs, P. A. A.; Ultee, J. M.

    2005-01-01

    A 56-year-old female patient suffered a bimalleolar ankle fracture with an additional proximal fibular fracture. This is an unusual fracture type, seldom reported in literature. It was operatively treated by open reduction and internal fixation of the lateral malleolar fracture. The proximal fibular

  10. Grouping by Proximity in Haptic Contour Detection

    Science.gov (United States)

    Overvliet, Krista E.; Krampe, Ralf Th.; Wagemans, Johan

    2013-01-01

    We investigated the applicability of the Gestalt principle of perceptual grouping by proximity in the haptic modality. To do so, we investigated the influence of element proximity on haptic contour detection. In the course of four sessions ten participants performed a haptic contour detection task in which they freely explored a haptic random dot display that contained a contour in 50% of the trials. A contour was defined by a higher density of elements (raised dots), relative to the background surface. Proximity of the contour elements as well as the average proximity of background elements was systematically varied. We hypothesized that if proximity of contour elements influences haptic contour detection, detection will be more likely when contour elements are in closer proximity. This should be irrespective of the ratio with the proximity of the background elements. Results showed indeed that the closer the contour elements were, the higher the detection rates. Moreover, this was the case independent of the contour/background ratio. We conclude that the Gestalt law of proximity applies to haptic contour detection. PMID:23762364

  11. Proximate analysis on four edible mushrooms ADEDAYO ...

    African Journals Online (AJOL)

    Michael Horsfall

    Vol. 15 (1) 9 - 11. Full-text Available Online at www.bioline.org.br/ja. Proximate analysis on four edible mushrooms. ADEDAYO, MAJEKODUNMI RACHEL. Nigerian Stored Product Research Institute, P.M.B.3032, Kano. ABSTRACT: Proximate study was conducted on four edible mushrooms commonly found in farmlands in.

  12. Proximate Sources of Collective Teacher Efficacy

    Science.gov (United States)

    Adams, Curt M.; Forsyth, Patrick B.

    2006-01-01

    Purpose: Recent scholarship has augmented Bandura's theory underlying efficacy formation by pointing to more proximate sources of efficacy information involved in forming collective teacher efficacy. These proximate sources of efficacy information theoretically shape a teacher's perception of the teaching context, operationalizing the difficulty…

  13. Phytochemical screening, proximate analysis and anticonvulsant ...

    African Journals Online (AJOL)

    Spigelia anthelmia is used traditionally in Southern Nigeria for the treatment of infant convulsion and epilepsy. This study investigated the phytochemical constituents, proximate analysis and anticonvulsant effect of the methanolic extract of Spigelia anthelmia. Phytochemical evaluation and proximate analysis was carried ...

  14. Design and validation of an automated method to detect known adverse drug reactions in MEDLINE: a contribution from the EU–ADR project

    Science.gov (United States)

    Avillach, Paul; Dufour, Jean-Charles; Diallo, Gayo; Salvo, Francesco; Joubert, Michel; Thiessard, Frantz; Mougin, Fleur; Trifirò, Gianluca; Fourrier-Réglat, Annie; Pariente, Antoine; Fieschi, Marius

    2013-01-01

    Objectives The aim of this research was to automate the search of publications concerning adverse drug reactions (ADR) by defining the queries used to search MEDLINE and by determining the required threshold for the number of extracted publications to confirm the drug/event association in the literature. Methods We defined an approach based on the medical subject headings (MeSH) ‘descriptor records’ and ‘supplementary concept records’ thesaurus, using the subheadings ‘chemically induced’ and ‘adverse effects’ with the ‘pharmacological action’ knowledge. An expert-built validation set of true positive and true negative drug/adverse event associations (n=61) was used to validate our method. Results Using a threshold of three of more extracted publications, the automated search method presented a sensitivity of 90% and a specificity of 100%. For nine different drug/event pairs selected, the recall of the automated search ranged from 24% to 64% and the precision from 93% to 48%. Conclusions This work presents a method to find previously established relationships between drugs and adverse events in the literature. Using MEDLINE, following a MeSH approach to filter the signals, is a valid option. Our contribution is available as a web service that will be integrated in the final European EU–ADR project (Exploring and Understanding Adverse Drug Reactions by integrative mining of clinical records and biomedical knowledge) automated system. PMID:23195749

  15. Design and validation of an automated method to detect known adverse drug reactions in MEDLINE: a contribution from the EU-ADR project.

    Science.gov (United States)

    Avillach, Paul; Dufour, Jean-Charles; Diallo, Gayo; Salvo, Francesco; Joubert, Michel; Thiessard, Frantz; Mougin, Fleur; Trifirò, Gianluca; Fourrier-Réglat, Annie; Pariente, Antoine; Fieschi, Marius

    2013-05-01

    The aim of this research was to automate the search of publications concerning adverse drug reactions (ADR) by defining the queries used to search MEDLINE and by determining the required threshold for the number of extracted publications to confirm the drug/event association in the literature. We defined an approach based on the medical subject headings (MeSH) 'descriptor records' and 'supplementary concept records' thesaurus, using the subheadings 'chemically induced' and 'adverse effects' with the 'pharmacological action' knowledge. An expert-built validation set of true positive and true negative drug/adverse event associations (n=61) was used to validate our method. Using a threshold of three of more extracted publications, the automated search method presented a sensitivity of 90% and a specificity of 100%. For nine different drug/event pairs selected, the recall of the automated search ranged from 24% to 64% and the precision from 93% to 48%. This work presents a method to find previously established relationships between drugs and adverse events in the literature. Using MEDLINE, following a MeSH approach to filter the signals, is a valid option. Our contribution is available as a web service that will be integrated in the final European EU-ADR project (Exploring and Understanding Adverse Drug Reactions by integrative mining of clinical records and biomedical knowledge) automated system.

  16. Intramedullary compression device for proximal ulna fracture.

    Science.gov (United States)

    Hong, Choon Chiet; Han, Fucai; Decruz, Joshua; Pannirselvam, Vinodhkumar; Murphy, Diarmuid

    2015-02-01

    Proximal ulna fractures account for 20% of all proximal forearm fractures. Many treatment options are available for such fractures, such as cast immobilisation, plate and screw fixation, tension band wiring and intramedullary screw fixation, depending on the fracture pattern. Due to the subcutaneous nature of the proximal forearm, it is vulnerable to open injuries over the dorsal aspect of the proximal ulna. This may in turn prove challenging, as it is critical to obtain adequate soft tissue coverage to reduce the risk of implant exposure and bony infections. We herein describe a patient with a Gustillo III-B open fracture of the proximal ulna, treated with minimally invasive intramedullary screw fixation using a 6.0-mm cannulated headless titanium compression screw (FusiFIX, Péronnas, France).

  17. Proximal Alternating Direction Method with Relaxed Proximal Parameters for the Least Squares Covariance Adjustment Problem

    Directory of Open Access Journals (Sweden)

    Minghua Xu

    2014-01-01

    Full Text Available We consider the problem of seeking a symmetric positive semidefinite matrix in a closed convex set to approximate a given matrix. This problem may arise in several areas of numerical linear algebra or come from finance industry or statistics and thus has many applications. For solving this class of matrix optimization problems, many methods have been proposed in the literature. The proximal alternating direction method is one of those methods which can be easily applied to solve these matrix optimization problems. Generally, the proximal parameters of the proximal alternating direction method are greater than zero. In this paper, we conclude that the restriction on the proximal parameters can be relaxed for solving this kind of matrix optimization problems. Numerical experiments also show that the proximal alternating direction method with the relaxed proximal parameters is convergent and generally has a better performance than the classical proximal alternating direction method.

  18. The Life Saving Effects of Hospital Proximity

    DEFF Research Database (Denmark)

    Bertoli, Paola; Grembi, Veronica

    We assess the lifesaving effect of hospital proximity using data on fatality rates of road-traffic accidents. While most of the literature on this topic is based on changes in distance to the nearest hospital triggered by hospital closures and use OLS estimates, our identification comes from......) increases the fatality rate by 13.84% on the sample average. This is equal to a 0.92 additional death per every 100 accidents. We show that OLS estimates provide a downward biased measure of the real effect of hospital proximity because they do not fully solve spatial sorting problems. Proximity matters...

  19. Data Extraction and Management in Networks of Observational Health Care Databases for Scientific Research: A Comparison of EU-ADR, OMOP, Mini-Sentinel and MATRICE Strategies

    Science.gov (United States)

    Gini, Rosa; Schuemie, Martijn; Brown, Jeffrey; Ryan, Patrick; Vacchi, Edoardo; Coppola, Massimo; Cazzola, Walter; Coloma, Preciosa; Berni, Roberto; Diallo, Gayo; Oliveira, José Luis; Avillach, Paul; Trifirò, Gianluca; Rijnbeek, Peter; Bellentani, Mariadonata; van Der Lei, Johan; Klazinga, Niek; Sturkenboom, Miriam

    2016-01-01

    Introduction: We see increased use of existing observational data in order to achieve fast and transparent production of empirical evidence in health care research. Multiple databases are often used to increase power, to assess rare exposures or outcomes, or to study diverse populations. For privacy and sociological reasons, original data on individual subjects can’t be shared, requiring a distributed network approach where data processing is performed prior to data sharing. Case Descriptions and Variation Among Sites: We created a conceptual framework distinguishing three steps in local data processing: (1) data reorganization into a data structure common across the network; (2) derivation of study variables not present in original data; and (3) application of study design to transform longitudinal data into aggregated data sets for statistical analysis. We applied this framework to four case studies to identify similarities and differences in the United States and Europe: Exploring and Understanding Adverse Drug Reactions by Integrative Mining of Clinical Records and Biomedical Knowledge (EU-ADR), Observational Medical Outcomes Partnership (OMOP), the Food and Drug Administration’s (FDA’s) Mini-Sentinel, and the Italian network—the Integration of Content Management Information on the Territory of Patients with Complex Diseases or with Chronic Conditions (MATRICE). Findings: National networks (OMOP, Mini-Sentinel, MATRICE) all adopted shared procedures for local data reorganization. The multinational EU-ADR network needed locally defined procedures to reorganize its heterogeneous data into a common structure. Derivation of new data elements was centrally defined in all networks but the procedure was not shared in EU-ADR. Application of study design was a common and shared procedure in all the case studies. Computer procedures were embodied in different programming languages, including SAS, R, SQL, Java, and C++. Conclusion: Using our conceptual framework

  20. Proximity and Collaboration in European Nanotechnology

    NARCIS (Netherlands)

    Cunningham, S.W.; Werker, C.

    2011-01-01

    Collaborations are particularly important for the development and deployment of technology. We analyze the influence of organizational, technological and geographical proximity on European nanotechnology collaborations with the help of a publication dataset and additional geographical information.

  1. Promoting proximal formative assessment with relational discourse

    Science.gov (United States)

    Scherr, Rachel E.; Close, Hunter G.; McKagan, Sarah B.

    2012-02-01

    The practice of proximal formative assessment - the continual, responsive attention to students' developing understanding as it is expressed in real time - depends on students' sharing their ideas with instructors and on teachers' attending to them. Rogerian psychology presents an account of the conditions under which proximal formative assessment may be promoted or inhibited: (1) Normal classroom conditions, characterized by evaluation and attention to learning targets, may present threats to students' sense of their own competence and value, causing them to conceal their ideas and reducing the potential for proximal formative assessment. (2) In contrast, discourse patterns characterized by positive anticipation and attention to learner ideas increase the potential for proximal formative assessment and promote self-directed learning. We present an analysis methodology based on these principles and demonstrate its utility for understanding episodes of university physics instruction.

  2. Ammonia transport in the proximal tubule.

    Science.gov (United States)

    Hamm, L L; Simon, E E

    1990-01-01

    The transport of ammonia in the proximal tubule is a complex interaction of a number of processes. Ammonia transport in the proximal tubule is clearly bidirectional; ammonia is secreted into the early proximal tubule lumen, but later in the proximal tubule, efflux out of the lumen may result in net ammonia reabsorption. Two mechanisms of ammonia transport have clearly been established: NH3 diffusion and NH4+ transport on the Na(+)-H+ exchanger. The relative contribution of these pathways to ammonia transport is still unsettled. Other pathways for ammonia transport, particularly NH4+ efflux out of the lumen, may be important as well. A variety of factors may modulate ammonia transport: plasma, cell and luminal pH, luminal flow rate, luminal potassium, and angiotensin II. Each of these factors also alters ammonia production rates and in most circumstances, ammonia transport appears to follow ammonia production rates.

  3. Proximate composition and cholesterol concentrations of ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-05-18

    DWB) for raw and fried samples, respectively, but decreased to 295.20 ... Key words: Rhynchophorus phoenicis, Oryctes monoceros, proximate composition, cholesterol, heat treatment. INTRODUCTION. Insects have played ...

  4. COMPARATIVE ANALYSIS OF PROXIMATE COMPOSITIONS OF ...

    African Journals Online (AJOL)

    Babatunde Emmanuel

    2011-10-06

    Oct 6, 2011 ... Fish allows for protein improved nutrition in that it has a high biological value in terms of high ... marine algae upon which the fish feed [11]. ... Proximate composition of catfish Clarias gariepinus and Tarpon atlanticus were.

  5. Phytochemical screening, proximate analysis and acute toxicity ...

    African Journals Online (AJOL)

    Phytochemical screening, proximate analysis and acute toxicity studies were carried out on the leaf extract of Cola lepidota, in accordance with established standard procedures. The proximate analysis reveals a moisture content of 27.43 ± 3.11 % w/w, total ash value 9.32 ± 0.27 % w/w, acid insoluble ash 3.12 ± 1.05 % w/w ...

  6. Proximate, Mineral and Phytochemical Composition of Dioscorea ...

    African Journals Online (AJOL)

    ADOWIE PERE

    ABSTRACT: Proximate, mineral and phytochemical composition of Dioscorea dumetorum tubers was investigated using standard procedures. Proximate analysis included in g% dry weight: crude protein (6.44 ± 0.32), crude fat (0.75 ± 0.04), crude fibre (15.00 ± 0.56), total ash. (3.45 ± 0.20) and a moisture content of 70.04 ...

  7. Painful Spastic Hip Dislocation: Proximal Femoral Resection

    OpenAIRE

    Albiñana, Javier; Gonzalez-Moran, Gaspar

    2002-01-01

    The dislocated hip in a non-ambulatory child with spastic paresis tends to be a painful interference to sleep, sitting upright, and perineal care. Proximal femoral resection-interposition arthroplasty is one method of treatment for this condition. We reviewed eight hips, two bilateral cases, with a mean follow-up of 30 months. Clinical improvement was observed in all except one case, with respect to pain relief and sitting tolerance. Some proximal migration was observed in three cases, despit...

  8. Proximity sensor system development. CRADA final report

    Energy Technology Data Exchange (ETDEWEB)

    Haley, D.C. [Oak Ridge National Lab., TN (United States); Pigoski, T.M. [Merrit Systems, Inc. (United States)

    1998-01-01

    Lockheed Martin Energy Research Corporation (LMERC) and Merritt Systems, Inc. (MSI) entered into a Cooperative Research and Development Agreement (CRADA) for the development and demonstration of a compact, modular proximity sensing system suitable for application to a wide class of manipulator systems operated in support of environmental restoration and waste management activities. In teleoperated modes, proximity sensing provides the manipulator operator continuous information regarding the proximity of the manipulator to objects in the workspace. In teleoperated and robotic modes, proximity sensing provides added safety through the implementation of active whole arm collision avoidance capabilities. Oak Ridge National Laboratory (ORNL), managed by LMERC for the United States Department of Energy (DOE), has developed an application specific integrated circuit (ASIC) design for the electronics required to support a modular whole arm proximity sensing system based on the use of capacitive sensors developed at Sandia National Laboratories. The use of ASIC technology greatly reduces the size of the electronics required to support the selected sensor types allowing deployment of many small sensor nodes over a large area of the manipulator surface to provide maximum sensor coverage. The ASIC design also provides a communication interface to support sensor commands from and sensor data transmission to a distributed processing system which allows modular implementation and operation of the sensor system. MSI is a commercial small business specializing in proximity sensing systems based upon infrared and acoustic sensors.

  9. Transformations through Proximity Flying: A Phenomenological Investigation

    Science.gov (United States)

    Holmbom, Maria; Brymer, Eric; Schweitzer, Robert D.

    2017-01-01

    Participation in extreme sports has been linked to personal transformations in everyday life. Descriptions of lived experience resulting from transformative experiences are limited. Proximity flying, a relatively new discipline involving BASE jumping with a wingsuit where participants fly close to solid structures, is arguably one of the most extreme of extreme sports. The aim of this paper, part of a larger phenomenological study on the lived experience of proximity flying, is to explicate the ways in which participating in proximity flying influences the everyday lives of participants. Interpretative phenomenological analysis was used to explicate the lived experience of six proximity pilots. An analysis of interview transcripts revealed three significant themes describing the lived experience of participants. First, experiences of change were described as positive and skills developed through proximity flying were transferable into everyday life. Second, transformative experiences were considered fundamental to participants’ perspectives on life. Third, experience of transformation influenced their sense of personal identity and facilitated flourishing in other aspects of everyday life. Participants were clear that their experiences in proximity flying facilitated a profound process of transformation which manifest as changes in everyday capabilities and behaviors, values and sense of identity. PMID:29104552

  10. Preparation and evaluation of poly(l-histidine based pH-sensitive micelles for intracellular delivery of doxorubicin against MCF-7/ADR cells

    Directory of Open Access Journals (Sweden)

    Nan Jia

    2017-09-01

    Full Text Available In this study, a pH-sensitive micelle self-assembled from poly(l-histidine based triblock copolymers of poly(ethylene glycol–poly(d,l-lactide–poly(l-histidine (mPEG-PLA-PHis was prepared and used as the intracellular doxorubicin (Dox delivery for cancer chemotherapy. Dox was loaded into the micelles by thin-film hydration method and a Box–Behnken design for three factors at three levels was used to optimize the preparations. The optimized mPEG-PLA-Phis/Dox micelles exhibited good encapsulation efficiency of 91.12%, a mean diameter of 45 nm and narrow size distribution with polydispersity index of 0.256. In vitro drug release studies demonstrated that Dox was released from the micelles in a pH-dependent manner. Furthermore, the cellular evaluation of Dox loaded micelles displayed that the micelles possessed high antitumor activity in vitro with an IC50 of 35.30 µg/ml against MCF-7/ADR cells. The confocal microscopy and flow cytometry experiments indicated that mPEG-PLA-Phis micelles mediated efficient cytoplasmic delivery of Dox with the aid of poly(l-histidine mediated endosomal escape. In addition, blank mPEG-PLA-Phis micelles were shown to be nontoxic to MCF-7/ADR cells even at a high concentration of 200 µg/ml. The pH-sensitive mPEG-PLA-PHis micelles have been demonstrated to be a promising nanosystem for the intracellular delivery of Dox for MDR reversal.

  11. LAJU PENURUNAN LOGAM BERAT PLUMBUM (PB DAN CADMIUM (CD OLEH EICHORNIA CRASSIPES DAN CYPERUS PAPYRUS (The Diminution Rate Of Heavy Metals, Plumbum And Cadmium By Eichornia Crassipes And Cyperus

    Directory of Open Access Journals (Sweden)

    Ramadhan Tosepu

    2012-03-01

    Full Text Available ABSTRAK Penelitian ini bertujuan untuk (1 menganalisis lama waktu (hari laju penurunan logam berat plumbum dan cadmium oleh Eichornia crassipes dan Cyperus papyrus. (2 membandingkan laju penurunan logam lumbum dan cadmium oleh Eichornia crassipes dan Cyperus papyrus. Penelitian ini dilaksanakan di Kota Makassar dengan pemeriksaan sampel air dilakukan di Laboratotium Balai Riset Perikanan Budidaya Air Payau Maros. Data dianalisis dengan menggunakan analisis statistik dengan uji T test dan uji Post Hoc Test. Hasil Penelitian menunjukkan bahwa konsentrasi logam berat plumbum lebih cepat terakumulasi habis dengan menggunakan tumbuhan Eichornia crassipes dibandingkan dengan menggunakan tumbuhan Cyperus papyrus. Logam berat plumbum dan cadmium memiliki laju penurunan yang cepat oleh tumbuhan Eichornia crassipes dibandingkan dengan tumbuhan Cyperus papyrus. ABSTRACT The aim of the study was to analyze the diminution rate of heavy metals, plumbum and cadmium by Eichornia crassipes and Cyperus papyrus and to compare the rate of their decrease. The study conducted in Makassar city by examining the water sample in the Brackish Water Culture Fishery Research in Maros.  The data were analyzed statistically by employing T test and Post Hoc test. The results of the study indicate that the concentration of heavy metal, plumbum is quicker by using Eichornia crassipes plant than the Cyperus papyrus plant. The heavy metals, plumbum and cadmium have rapid rates of diminution by  Eichornia crassipes plant than the Cyperus papyrus plant.

  12. Treatment of three- and four-part proximal humeral fractures with locking proximal humerus plate.

    Science.gov (United States)

    Sun, Jing-Cheng; Li, Yu-Lin; Ning, Guang-Zhi; Wu, Qiang; Feng, Shi-Qing

    2013-08-01

    The purpose of this study was to evaluate the effectiveness and complications of the locking proximal humerus plate to treat proximal humerus fractures. A retrospective clinical trial. Department of Orthopaedics, Tianjin Medical University General Hospital. Sixty-eight consecutive patients with three- or four-part fractures of the proximal humerus were treated with locking proximal humerus plates. The deltopectoral anterolateral acromial approach was used to the proximal humerus; open reduction and locking proximal humerus plate were applied. Constant Score was used to measure the shoulder functional recovery, and Visual Analog Scale (VAS) was used to measure subjective evaluation of pain. The radiology was observed. After average 26.7 months, the average Constant Score was 72.6 ± 13.2 points and the average VAS was 1.2 ± 0.8 points. All the complications such as screw perforation into the glenohumeral joint, screws loosening, soft tissue infections, avascular necrosis and delayed union occurred in eight cases (11.8 %). The effectiveness of the locking proximal humerus plate was similar to other published literatures on treating fractures of the proximal humerus; however, a lower complications rate in short follow-up time was observed in this study. It may potentially provide a favorable option for treating three- or four-part fractures of the proximal humerus. Dealing with each particular fracture pattern, surgeons should have a decision of appropriate way to internal fixation.

  13. Locking plate fixation for proximal humerus fractures.

    LENUS (Irish Health Repository)

    Burke, Neil G

    2012-02-01

    Locking plates are increasingly used to surgically treat proximal humerus fractures. Knowledge of the bone quality of the proximal humerus is important. Studies have shown the medial and dorsal aspects of the proximal humeral head to have the highest bone strength, and this should be exploited by fixation techniques, particularly in elderly patients with osteoporosis. The goals of surgery for proximal humeral fractures should involve minimal soft tissue dissection and achieve anatomic reduction of the head complex with sufficient stability to allow for early shoulder mobilization. This article reviews various treatment options, in particular locking plate fixation. Locking plate fixation is associated with a high complication rate, such as avascular necrosis (7.9%), screw cutout (11.6%), and revision surgery (13.7%). These complications are frequently due to the varus deformation of the humeral head. Strategic screw placement in the humeral head would minimize the possibility of loss of fracture reduction and potential hardware complications. Locking plate fixation is a good surgical option for the management of proximal humerus fractures. Complications can be avoided by using better bone stock and by careful screw placement in the humeral head.

  14. Industrial Computed Tomography using Proximal Algorithm

    KAUST Repository

    Zang, Guangming

    2016-04-14

    In this thesis, we present ProxiSART, a flexible proximal framework for robust 3D cone beam tomographic reconstruction based on the Simultaneous Algebraic Reconstruction Technique (SART). We derive the proximal operator for the SART algorithm and use it for minimizing the data term in a proximal algorithm. We show the flexibility of the framework by plugging in different powerful regularizers, and show its robustness in achieving better reconstruction results in the presence of noise and using fewer projections. We compare our framework to state-of-the-art methods and existing popular software tomography reconstruction packages, on both synthetic and real datasets, and show superior reconstruction quality, especially from noisy data and a small number of projections.

  15. Correlation between social proximity and mobility similarity.

    Science.gov (United States)

    Fan, Chao; Liu, Yiding; Huang, Junming; Rong, Zhihai; Zhou, Tao

    2017-09-20

    Human behaviors exhibit ubiquitous correlations in many aspects, such as individual and collective levels, temporal and spatial dimensions, content, social and geographical layers. With rich Internet data of online behaviors becoming available, it attracts academic interests to explore human mobility similarity from the perspective of social network proximity. Existent analysis shows a strong correlation between online social proximity and offline mobility similarity, namely, mobile records between friends are significantly more similar than between strangers, and those between friends with common neighbors are even more similar. We argue the importance of the number and diversity of common friends, with a counter intuitive finding that the number of common friends has no positive impact on mobility similarity while the diversity plays a key role, disagreeing with previous studies. Our analysis provides a novel view for better understanding the coupling between human online and offline behaviors, and will help model and predict human behaviors based on social proximity.

  16. [Disorders of sex development and proximal hypospadias].

    Science.gov (United States)

    Oswald, J

    2016-01-01

    Children with ambiguous genitalia due to different chromosome or gonadal sex are a particular challenge concerning the diagnostic and therapeutic implications. Proximal hypospadias patients with normal gonadal development should be distinguished from children with DSD (disorders of sex development) to guarantee normal gender identity and the best possible surgical therapy. This paper focuses on the terminology, embryology, and pathophysiology of the different manifestations of DSD. The state of knowledge about this disease pattern with particular emphasis on proximal hypospadias based on national and international scientific discussions is presented. The different clinical pictures as well as therapeutic options of DSD with a special focus on recent literature and giving particular attention to patients with proximal hypospadias are presented. Because of the complexity of patients suffering from disorders of sex development an interdisciplinary DSD healthcare team including a paediatric endocrinologist as well as paediatric urologist should be provided. These specialists enable an accurate diagnosis in severe hypospadias patients without reference to DSD diseases patterns.

  17. Infiltrating/sealing proximal caries lesions

    DEFF Research Database (Denmark)

    Martignon, S; Ekstrand, K R; Gomez, J

    2012-01-01

    This randomized split-mouth controlled clinical trial aimed at assessing the therapeutic effects of infiltration vs. sealing for controlling caries progression on proximal surfaces. Out of 90 adult students/patients assessed at university clinics and agreeing to participate, 39, each with 3...... differences in lesion progression between infiltration and placebo (P = 0.0012) and between sealing and placebo (P = 0.0269). The study showed that infiltration and sealing are significantly better than placebo treatment for controlling caries progression on proximal lesions. No significant difference...... proximal lesions identified radiographically around the enamel-dentin junction to the outer third of the dentin, were included. Lesions were randomly allocated for treatment to test-A (Infiltration: ICON-pre-product; DMG), test-B (Sealing: Prime-Bond-NT; Dentsply), or control-C (Placebo). Primary outcome...

  18. Knowledge networks in the Dutch aviation industry: The proximity paradox

    NARCIS (Netherlands)

    Broekel, T.; Boschma, R.A.

    2012-01-01

    The importance of geographical proximity for interaction and knowledge sharing has been discussed extensively in recent years. There is increasing consensus that geographical proximity is just one out of many types of proximities that might be relevant. We argue that proximity may be a crucial

  19. The developmental spectrum of proximal radioulnar synostosis

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, Alison M. [University of Manitoba, Winnipeg Regional Health Association Program of Genetics and Metabolism, Winnipeg, MB (Canada); University of Manitoba, Department of Paediatrics and Child Health, Winnipeg, MB (Canada); University of Manitoba, Department of Biochemistry and Medical Genetics, Winnipeg, MB (Canada); University of Manitoba, WRHA Program of Genetics and Metabolism, Departments of Paediatrics and Child Health, Biochemistry and Medical Genetics, Winnipeg, MB (Canada); Kibria, Lisa [University of Manitoba, Department of School of Medical Rehabilitation, Winnipeg, MB (Canada); Reed, Martin H. [University of Manitoba, Department of Paediatrics and Child Health, Winnipeg, MB (Canada); University of Manitoba, Department of Biochemistry and Medical Genetics, Winnipeg, MB (Canada); University of Manitoba, Department of Diagnostic Imaging, Winnipeg, MB (Canada)

    2010-01-15

    Proximal radioulnar synostosis is a rare upper limb malformation. The elbow is first identifiable at 35 days (after conception), at which stage the cartilaginous anlagen of the humerus, radius and ulna are continuous. Subsequently, longitudinal segmentation produces separation of the distal radius and ulna. However, temporarily, the proximal ends are united and continue to share a common perichondrium. We investigated the hypothesis that posterior congenital dislocation of the radial head and proximal radioulnar fusion are different clinical manifestations of the same primary developmental abnormality. Records were searched for ''proximal radioulnar fusion/posterior radial head dislocation'' in patients followed at the local Children's Hospital and Rehabilitation Centre for Children. Relevant radiographic, demographic and clinical data were recorded. Ethics approval was obtained through the University Research Ethics Board. In total, 28 patients met the inclusion criteria. The majority of patients (16) had bilateral involvement; eight with posterior dislocation of the radial head only; five had posterior radial head dislocation with radioulnar fusion and two had radioulnar fusion without dislocation. One patient had bilateral proximal radioulnar fusion and posterior dislocation of the left radial head. Nine patients had only left-sided involvement, and three had only right-sided involvement.The degree of proximal fusion varied, with some patients showing 'complete' proximal fusion and others showing fusion that occurred slightly distal to the radial head: 'partially separated.' Associated disorders in our cohort included Poland syndrome (two patients), Cornelia de Lange syndrome, chromosome anomalies (including tetrasomy X) and Cenani Lenz syndactyly. The suggestion of a developmental relationship between posterior dislocation of the radial head and proximal radioulnar fusion is supported by the fact that both anomalies

  20. preliminary phytochemical screening, proximate and elemental

    African Journals Online (AJOL)

    DR. AMINU

    ABSTRACT. The seed powder of Moringa oleifera was analysed for its phytochemical, proximate and elemental composition using Folin-Denis spectrophotometric method, gravimetric method and energy dispersing X-ray fluorescence (EDXRF) transmission emission technique respectively. The seed powder had the ...

  1. Proximate, mineral composition, antioxidant activity, and total ...

    African Journals Online (AJOL)

    Four varieties of the red pepper fruits (Capsicum species) were evaluated for chemical composition, antioxidant activity and total phenolic contents using standard analytical technique, ferric-ion reducing antioxidant potential (FRAP) assay and Folin-Colcalteau method respectively. The proximate composition values ...

  2. 9__43 - 50__Tijjani_Proximate

    African Journals Online (AJOL)

    User

    Sena et al., 1998). In Nigeria, the plant is commonly consumed by the Hausa speaking communities as a spice and a sauce (Ibrahim et al., 2012). However, during preparation the leaves and stem are not carefully separated before processing of food. Thus, the present study was aimed at evaluating the proximate, minerals ...

  3. Phytochemistry and proximate composition of ginger ( Zingiber ...

    African Journals Online (AJOL)

    ... a little crude fibre content of 0.92 %. The results indicated that ginger rhizome is an excellent natural remedy for a wide range of ailments. Keywords: Zingiber officinale, spice, rhizome, phytochemistry, proximate analysis, Zingiberaceae, zingerone, methanolic extraction. Journal of Pharmaceutical and Allied Sciences, Vol.

  4. DEPRESSIONARY EFFECT OF PROXIMITY OF RESIDENTIAL ...

    African Journals Online (AJOL)

    Osondu

    2012-10-24

    Oct 24, 2012 ... opinions are analyzed and it revealed that the site has major impacts on the residents perceived quality of life, security and ... Key words: Landfill, Property value, Health and safety, Residential property, Solous. Introduction. The location ... Proximity to landfills and hazardous waste sites can severely affect ...

  5. Renal fibrosis: Primacy of the proximal tubule.

    Science.gov (United States)

    Gewin, Leslie S

    2018-02-06

    Tubulointerstitial fibrosis (TIF) is the hallmark of chronic kidney disease and best predictor of renal survival. Many different cell types contribute to TIF progression including tubular epithelial cells, myofibroblasts, endothelia, and inflammatory cells. Previously, most of the attention has centered on myofibroblasts given their central importance in extracellular matrix production. However, emerging data focuses on how the response of the proximal tubule, a specialized epithelial segment vulnerable to injury, plays a central role in TIF progression. Several proximal tubular responses such as de-differentiation, cell cycle changes, autophagy, and metabolic changes may be adaptive initially, but can lead to maladaptive responses that promote TIF both through autocrine and paracrine effects. This review discusses the current paradigm of TIF progression and the increasingly important role of the proximal tubule in promoting TIF both in tubulointerstitial and glomerular injuries. A better understanding and appreciation of the role of the proximal tubule in TIF has important implications for therapeutic strategies to halt chronic kidney disease progression. Copyright © 2017 International Society of Matrix Biology. Published by Elsevier B.V. All rights reserved.

  6. 182 179 Comparative Study on the Proximate

    African Journals Online (AJOL)

    2008-12-02

    Dec 2, 2008 ... Key words: Annona squamosa, Fruits, Proximate, Minerals, nutrient density. INTRODUCTION. Sugar apple (Annona squamosa) also called. “Gwanda masar” in Hausa belong to the family. Annonacae. The most widely grown of all the species are A. muricata, A. cherimola, A reticulata, A. senegalensis and ...

  7. Phytochemical Screening, Proximate and Mineral Composition of ...

    African Journals Online (AJOL)

    Leaves of sweet potato (Ipomoea batatas) grown in Tepi area was studied for their class of phytochemicals, mineral and proximate composition using standard analytical methods. The phytochemical screening revealed the presence of alkaloids, flavonoid, terpenoids, saponins, quinones, phenol, tannins, amino acid and ...

  8. Phytochemical screening, proximate and elemental analysis of ...

    African Journals Online (AJOL)

    Citrus sinensis was screened for its phytochemical composition and was evaluated for the proximate and elemental analysis. The phytochemical analysis indicated the presence of reducing sugar, saponins, cardiac glycosides, tannins and flavonoids. The elemental analysis indicated the presence of the following mineral ...

  9. Phytochemical Screening and Proximate Analysis of Newbouldia ...

    African Journals Online (AJOL)

    The study was conducted to assess the phytochemical and proximate composition of Newboudia laevis leaves and Allium sativum bulb extracts. The leaves and bulbs extracts were analyzed for their chemical composition and antinutritional factors (ANFs) which include moisture, crude protein, crude fat, crude fiber, total ash ...

  10. Disability occurrence and proximity to death

    NARCIS (Netherlands)

    Klijs, Bart; Mackenbach, Johan P.; Kunst, Anton E.

    2010-01-01

    Purpose. This paper aims to assess whether disability occurrence is related more strongly to proximity to death than to age. Method. Self reported disability and vital status were available from six annual waves and a subsequent 12-year mortality follow-up of the Dutch GLOBE longitudinal study.

  11. [Four family members with proximal myotonic myopathy

    NARCIS (Netherlands)

    Tieleman, A.A.; Velden, M.P. van der; Visser, M.C.; Wokke, J.H.J.; Scheffer, H.; Engelen, B.G.M. van

    2004-01-01

    A 41-year-old woman had a 15-year history of pain in her thighs and arms, which also became weaker, and a decrease in visual acuity. Her 35-year-old brother, their 38-year-old sister and their 64-year-old mother also had myalgia, myotonia and proximal muscle weakness, and the women also had

  12. Phytochemical screening, proximate and elemental analysis of ...

    African Journals Online (AJOL)

    ... was about 0.01 in concentration. Proximate analysis also shows that it has a high nutritional value such as carbohydrate, fibre, Ash, fat and protein. These results recommended the consumption of these peels of desired physiochemical properties as sources of food fibres or low-calorie bulk ingredients in food applications ...

  13. Proximate composition and consumer acceptability of African ...

    African Journals Online (AJOL)

    The aim of the study was to assess the organoleptic differences of Clarias gariepinus smoked with two different energy sources, Anogeissus leiocarpus and Tamarindus indica with the help of a hedonic scale and to determine possible proximate composition difference between the smoked products. Smoking of the fishes ...

  14. Controllable proximity effect in superconducting hybrid devices

    NARCIS (Netherlands)

    Bakurskiy, S.V.

    2015-01-01

    This thesis is devoted to the study of controllable proximity effects in superconductors, both in terms of fundamental aspects and applications. As a part of this thesis theoretical description was suggested for a number of structures with superconducting electrodes and multiple interlayers. These

  15. Proximate, chemical compositions and sulphur concentrations on ...

    African Journals Online (AJOL)

    0, 10, 20, 50, 100, 150, 200, 250 and 300 ppm) on the nutritional value and the proximate composition of six selected mango cultivars (Tommy Atkins, Peach, Saber, Sunshine, Keitt and Vhavenda) grown in South Africa. The study shows that ...

  16. Proximate composition, bread characteristics and sensory ...

    African Journals Online (AJOL)

    This study was carried out to investigate proximate composition, bread characteristics and sensory evaluation of cocoyam-wheat composite breads at different levels of cocoyam flour substitution for human consumption.A whole wheat bread (WWB) and cocoyam-composite breads (CCB1,CCB 2 and CCB 3) were prepared ...

  17. Evaluation of the Proximate, Chemical and Phytochemical ...

    African Journals Online (AJOL)

    The increased interest in the utilization of the leaves of Moringa oleifera necessitated this study which evaluated the proximate, chemical and phytochemical composition, especially the presence of anti- physiological and toxic factors in the leaves. The results of the phytochemical analyses were: alkaloid 1.24 ± 0.141%; ...

  18. comparative proximate composition and antioxidant vitamins

    African Journals Online (AJOL)

    DR. AMINU

    ABSTRACT. The proximate composition and antioxidant vitamins analysis of two varieties of honey (dark amber and light amber) were carried out using standard methods. The values for moisture, ash, crude lipid, crude protein and crude carbohydrate contents of the two honeys, (light amber and dark amber) are 9.39 ...

  19. Proximate composition and cholesterol concentrations of ...

    African Journals Online (AJOL)

    Proximate composition and cholesterol concentrations of Rhynchophorus phoenicis and Oryctes monoceros larvae subjected to different heat treatments. ... 514.63 mg/100g dry weight basis (DWB) for raw and fried samples, respectively, but decreased to 295.20 mg/100 g DWB in the smoke-dried samples. Similarly, the ...

  20. Preliminary Phytochemical Screening, Elemental and Proximate ...

    African Journals Online (AJOL)

    The study aimed at phytochemical screening, elemental and proximate composition of two varieties of Cyperus esculentus (tiger nut) big yellow and small brown nuts using standard methods. The phytochemicals tested for were alkaloid, saponin, tannin, glycoside, flavonoid, steroid and resin. All the aforementioned ...

  1. Protein biomarker validation via proximity ligation assays.

    Science.gov (United States)

    Blokzijl, A; Nong, R; Darmanis, S; Hertz, E; Landegren, U; Kamali-Moghaddam, M

    2014-05-01

    The ability to detect minute amounts of specific proteins or protein modifications in blood as biomarkers for a plethora of human pathological conditions holds great promise for future medicine. Despite a large number of plausible candidate protein biomarkers published annually, the translation to clinical use is impeded by factors such as the required size of the initial studies, and limitations of the technologies used. The proximity ligation assay (PLA) is a versatile molecular tool that has the potential to address some obstacles, both in validation of biomarkers previously discovered using other techniques, and for future routine clinical diagnostic needs. The enhanced specificity of PLA extends the opportunities for large-scale, high-performance analyses of proteins. Besides advantages in the form of minimal sample consumption and an extended dynamic range, the PLA technique allows flexible assay reconfiguration. The technology can be adapted for detecting protein complexes, proximity between proteins in extracellular vesicles or in circulating tumor cells, and to address multiple post-translational modifications in the same protein molecule. We discuss herein requirements for biomarker validation, and how PLA may play an increasing role in this regard. We describe some recent developments of the technology, including proximity extension assays, the use of recombinant affinity reagents suitable for use in proximity assays, and the potential for single cell proteomics. This article is part of a Special Issue entitled: Biomarkers: A Proteomic Challenge. © 2013.

  2. Phytochemical screening, proximate and elemental analysis of ...

    African Journals Online (AJOL)

    Michael Horsfall

    2009). The aim of this study was to analyses the extract of. Citrus sinensis peels for the phytochemical, proximate and elemental composition. MATERIALS AND METHODS. Plant materials Fresh peels of Citrus sinensis were collected from Uselu market in Benin City, Edo. State, Nigeria. It was identified and authenticated by.

  3. Keldysh proximity action for disordered superconductors

    Indian Academy of Sciences (India)

    Abstract. We review a novel approach to the superconductive proximity effect in dis- ordered normal–superconducting (N–S) structures. The method is based on the multi- charge Keldysh action and is suitable for the treatment of interaction and fluctuation effects. As an application of the formalism, we study the subgap ...

  4. Goal-Proximity Decision-Making

    Science.gov (United States)

    Veksler, Vladislav D.; Gray, Wayne D.; Schoelles, Michael J.

    2013-01-01

    Reinforcement learning (RL) models of decision-making cannot account for human decisions in the absence of prior reward or punishment. We propose a mechanism for choosing among available options based on goal-option association strengths, where association strengths between objects represent previously experienced object proximity. The proposed…

  5. Internal fixation of proximal humerus fractures using the T2-proximal humeral nail.

    Science.gov (United States)

    Popescu, Dragos; Fernandez-Valencia, Jenaro A; Rios, Moisés; Cuñé, Jordi; Domingo, Anna; Prat, Salvi

    2009-09-01

    Surgical management of proximal humerus fractures remains controversial and there is an increasing interest in intramedullary nailing. Created to improve previous designs, the T2-proximal humeral nail (PHN) (Stryker) has been recently released, and the English literature lacks a series evaluating its results. We present a clinical prospective study evaluating this implant for proximal humeral fractures. We evaluated the functional and radiological results and possible complications. Twenty-nine patients with displaced fractures of the proximal humerus were treated with this nail. One patient was lost right after surgery and excluded from the assessment. Eighteen patients were older than 70 years. There were 21 fractures of the proximal part of the humerus and 7 fractures that also involved the shaft; 15 of the fractures were two-part fractures (surgical neck), 5 were three-part fractures, and 1 was a four-part fracture. All fractures healed in a mean period of 2.7 months. There was one delayed union that healed in 4 months. One case of avascular necrosis of the humeral head was observed (a four-part fracture), but remained asymptomatic and did not require further treatment. In one case a back-out of one proximal screw was observed. A final evaluation with a minimum 1 year follow-up was performed by an independent observer; in 18 patients, the mean Constant score was 65.7 or 76.1% with the adjustment of age and gender; in 19 patients, the mean Oxford Shoulder Score was 21.7. The results obtained with the T2-PHN nail indicate that it represents a safe and reliable method in the treatment of two- and three-part fractures of the proximal humerus. The proximal fixation mechanism diminishes the rate of back-out of the screws, a frequent complication described in the literature. Better functional results were obtained from the patients younger than 70 years, but these were not statistically significant.

  6. Proximal tubular hypertrophy and enlarged glomerular and proximal tubular urinary space in obese subjects with proteinuria.

    Directory of Open Access Journals (Sweden)

    Ana Tobar

    Full Text Available BACKGROUND: Obesity is associated with glomerular hyperfiltration, increased proximal tubular sodium reabsorption, glomerular enlargement and renal hypertrophy. A single experimental study reported an increased glomerular urinary space in obese dogs. Whether proximal tubular volume is increased in obese subjects and whether their glomerular and tubular urinary spaces are enlarged is unknown. OBJECTIVE: To determine whether proximal tubules and glomerular and tubular urinary space are enlarged in obese subjects with proteinuria and glomerular hyperfiltration. METHODS: Kidney biopsies from 11 non-diabetic obese with proteinuria and 14 non-diabetic lean patients with a creatinine clearance above 50 ml/min and with mild or no interstitial fibrosis were retrospectively analyzed using morphometric methods. The cross-sectional area of the proximal tubular epithelium and lumen, the volume of the glomerular tuft and of Bowman's space and the nuclei number per tubular profile were estimated. RESULTS: Creatinine clearance was higher in the obese than in the lean group (P=0.03. Proteinuria was similarly increased in both groups. Compared to the lean group, the obese group displayed a 104% higher glomerular tuft volume (P=0.001, a 94% higher Bowman's space volume (P=0.003, a 33% higher cross-sectional area of the proximal tubular epithelium (P=0.02 and a 54% higher cross-sectional area of the proximal tubular lumen (P=0.01. The nuclei number per proximal tubular profile was similar in both groups, suggesting that the increase in tubular volume is due to hypertrophy and not to hyperplasia. CONCLUSIONS: Obesity-related glomerular hyperfiltration is associated with proximal tubular epithelial hypertrophy and increased glomerular and tubular urinary space volume in subjects with proteinuria. The expanded glomerular and urinary space is probably a direct consequence of glomerular hyperfiltration. These effects may be involved in the pathogenesis of obesity

  7. [Arthroscopic fracture management in proximal humeral fractures].

    Science.gov (United States)

    Lill, H; Katthagen, C; Jensen, G; Voigt, C

    2013-04-01

    Arthroscopy has become increasingly more established in the treatment of proximal humeral fractures. In addition to the known advantages of minimally invasive surgery fracture and implant positioning can be optimized and controlled arthroscopically and relevant intra-articular concomitant pathologies (e.g. biceps tendon complex and rotator cuff) can be diagnosed and treated. Arthroscopic techniques have proven to be advantageous in the treatment of various entities of greater tuberosity fractures, lesser tuberosity fractures (suture bridging technique) and subcapital humeral fractures (arthroscopic nailing). This article presents an overview on innovative arthroscopic modalities for treating proximal humeral fractures, describes the surgical techniques and the advantages compared to open procedures as well as initial clinical results.

  8. SINA: A test system for proximity fuses

    Science.gov (United States)

    Ruizenaar, M. G. A.

    1989-04-01

    SINA, a signal generator that can be used for testing proximity fuses, is described. The circuitry of proximity fuses is presented; the output signal of the RF circuit results from a mixing of the emitted signal and received signal that is Doppler shifted in frequency by the relative motion of the fuse with respect to the reflecting target of surface. With SINA, digitized and stored target and clutter signals (previously measured) can be transformed to Doppler signals, for example during a real flight. SINA can be used for testing fuse circuitry, for example in the verification of results of computer simulations of the low frequency Doppler signal processing. The software of SINA and its use are explained.

  9. Tunable Magnetic Proximity Effects in Graphene Junctions

    Science.gov (United States)

    Lazic, Predrag; Belashchenko, Kirill; Zutic, Igor

    2015-03-01

    The characteristic length of the magnetic proximity effects exceed the thickness of a graphene layer leading to an important, but typically overlooked, modifications of equilibrium and transport properties, as well as the implications for graphene spintronics. Using the first-principles studies that integrate a real space density functional theory (GPAW) with the state-of-the art boundary elements electrostatic code based on the Robin Hood method, we explore tunable electronic structure and magnetic proximity effects in the ferromagnet/insulator/graphene junctions. We show that the inclusion of a finite-size gate electrodes and van der Walls interaction lead to nontrivial effects that could also be important in other two-dimensional materials beyond graphene. Work supported by US ONR, NSF-DMR and Nebraska NSF MRSEC.

  10. Management of Proximal Third Arm Replantation

    Directory of Open Access Journals (Sweden)

    Süleyman Taş

    2017-12-01

    Full Text Available Notwithstanding the recent success in major limb replantation achieved through the advancements in microsurgical techniques, the viability of the extremity is still relatively low at the transhumeral level following a replantation. There are no exact guidelines for deciding whether to undertake a stump repair or a replantation in such amputations at the proximal level. However, a highly motivated patient with realistic expectations and protected shoulder function can be a candidate to undergo replantation. The replanted arm may help the uninjured arm in daily activities. In this report we present the case of a 47-year-old man whose arm was amputated at proximal third level by an asphalt machine and successfully replanted together with the encountered problems and their solutions. The roadmap followed in this rare case may be a guide for hand surgeons.

  11. Dedifferentiated chondrosarcoma of right proximal femur

    Directory of Open Access Journals (Sweden)

    Sachin A Badge

    2016-01-01

    Full Text Available Dedifferentiated chondrosarcoma (DDCS comprises approximately 10% of all chondrosarcomas. The tumor generally occurs after the age of 50 years, with equal distribution among males and females. It is most often located in the bones of the pelvis, the proximal femur or humerus, the distal femur, and the ribs. Regardless of treatment, the prognosis is ominous with 90% of patients dying with distant metastases within 2 years. We report a case of DDCS of right proximal femur in a 73-year-old woman. The most important factors affecting survival are early recognition of the radiographic features, adequate histological sampling, and wide-margin resection of the lesion. So for the correct histopathological diagnosis the biopsy sample should be adequate to visualize both cartilaginous and noncartilaginous sarcomatous component which helps to increase the survival of patients before the distant metastasis occurs.

  12. Management of Acute Proximal Humeral Fractures.

    Science.gov (United States)

    Kancherla, Vamsi Krishna; Singh, Anshuman; Anakwenze, Oke A

    2017-01-01

    Proximal humeral fractures, which typically occur in elderly persons, are among the most common fractures. A myriad of nonsurgical and surgical treatment options exist for these injuries, including short-term immobilization and early physical therapy, percutaneous fixation, plate osteosynthesis, intramedullary nailing, hemiarthroplasty, and reverse shoulder arthroplasty. The choice of treatment depends on the fracture type and severity, surgeon expertise, patient age, and patient health status.

  13. Superconducting proximity effect in clean ferromagnetic layers

    OpenAIRE

    Zareyan, M.; Belzig, W.; Nazarov, Yu. V.

    2002-01-01

    We investigate the superconducting proximity effect in clean ferromagnetic layers with rough boundaries. The subgap density of states is formed by Andreev bound states at energies which depend on trajectory length and the ferromagnetic exchange field. At energies above the gap, the spectrum is governed by resonant scattering states. The resulting density of states, measurable by tunneling spectroscopy, exhibits a rich structure, which allows us to connect the theoretical parameters from exper...

  14. Alternating proximal algorithm for blind image recovery

    OpenAIRE

    Bolte, Jérôme; Combettes, Patrick Louis; Pesquet, Jean-Christophe

    2010-01-01

    International audience; We consider a variational formulation of blind image recovery problems. A novel iterative proximal algorithm is proposed to solve the associated nonconvex minimization problem. Under suitable assumptions, this algorithm is shown to have better convergence properties than standard alternating minimization techniques. The objective function includes a smooth convex data fidelity term and nonsmooth convex regularization terms modeling prior information on the data and on ...

  15. Transverse Stress Fracture of the Proximal Patella

    Science.gov (United States)

    Atsumi, Satoru; Arai, Yuji; Kato, Ko; Nishimura, Akinobu; Nakazora, Shigeto; Nakagawa, Shuji; Ikoma, Kazuya; Fujiwara, Hiroyoshi; Sudo, Akihiro; Kubo, Toshikazu

    2016-01-01

    Abstract Among stress fractures associated with sports activities, patellar stress fracture is rare. Regarding patella stress fractures, so far only distal transverse or lateral longitudinal fractures have been reported, but there are no reports of transverse fractures occurring in the proximal patella. We describe an extremely rare case of transverse stress fracture of proximal patella in a 9-year-old athlete. A 9-year old boy, who participated in sports (sprints and Kendo) presented with left knee pain without any external injury. In plain radiographs, a fracture line was observed in the proximal 1/3 of the left patella, and a patella stress fracture was diagnosed. For treatment, because 7 months of conservative therapy showed no improvement, internal fixation was carried out using Acutrak screws, and bone union was thus achieved. Three months after the operation, he was able to return to his previous level of athletic sports activity. Regarding the mechanism of onset, it is believed that the causes are longitudinal traction force and patellofemoral contact pressure. On the other hand, the contact region of the patella with the femur changes with the flexion angle of the knee. In the current case, the fracture occurred at a site where the patella was in contact with the femur at a flexion angle of >90°, so it is believed that it occurred as a clinical condition from being subjected to repeated longitudinal traction force and patellofemoral contact pressure at a flexion angle of >90°, during the sports activities of sprints and Kendo. The nonunion of the transverse stress fracture of his proximal patella was successfully treated with internal fixation using Acutrak screws. PMID:26871789

  16. Isolated Proximal Tibiofibular Dislocation during Soccer

    Directory of Open Access Journals (Sweden)

    Casey Chiu

    2015-01-01

    Full Text Available Proximal tibiofibular dislocations are rarely encountered in the Emergency Department (ED. We present a case involving a man presenting to the ED with left knee pain after making a sharp left turn on the soccer field. His physical exam was only remarkable for tenderness over the lateral fibular head. His X-rays showed subtle abnormalities of the tibiofibular joint. The dislocation was reduced and the patient was discharged from the ED with orthopedic follow-up.

  17. Capacitive Proximity Sensor Has Longer Range

    Science.gov (United States)

    Vranish, John M.

    1992-01-01

    Capacitive proximity sensor on robot arm detects nearby object via capacitive effect of object on frequency of oscillator. Sensing element part of oscillator circuit operating at about 20 kHz. Total capacitance between sensing element and ground constitutes tuning capacitance of oscillator. Sensor circuit includes shield driven by replica of alternating voltage applied to sensing element. Driven shield concentrates sensing electrostatic field in exterior region to enhance sensitivity to object. Sensitivity and dynamic range has corresponding 12-to-1 improvement.

  18. THE PROXIMATE COMPOSITION OF AFRICAN BUSH MANGO ...

    African Journals Online (AJOL)

    BIG TIMMY

    The proximate analysis (moisture, crude protein, crude fat, mineral ash and total carbohydrates) in the kernels and flour of African Bush Mango (. ) were investigated. The results revealed that the kernels contained moisture (2.5 g/100 g), crude protein (8.9 g/100 g), crude fat (68.4 g/100 g), mineral ash (2.3 g/100 g) and total ...

  19. [Proximity and breastfeeding at the maternity hospital].

    Science.gov (United States)

    Fradin-Charrier, Anne-Claire

    2015-01-01

    The establishment of breastfeeding, as well as its duration, are facilitated through the proximity of the mother with her new baby. However, in maternity hospitals, breastfeeding mothers very often leave their baby in the nursery at night time. A study carried out in 2014 in several maternity hospitals put forward suggestions and highlighted areas to improve in everyday practice. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  20. Sistemas de Resolución Alternativa de Conflictos (ADR en derecho tributario español y comparado. Propuestas para Latinoamérica y España

    Directory of Open Access Journals (Sweden)

    Eva Andrés Aucejo

    2016-12-01

    Full Text Available En línea con la opinión del Departamento de Derechos de los Ciudadanos y Asuntos Constitucionales del Parlamento Europeo (2014, en este artículo se aboga por la inclusión de los sistemas alternativos de resolución de conflictos (ADR como sistemas absolutamente cooperantes a la reducción de la litigiosidad en aquellos países como España y muchos Estados de Latinoamérica donde desafortunadamente la litigiosidad tributaria es un hecho de difícil erradicación. Tras ser analizados los principales referentes mundiales internacionales de ADR en derecho tributario comparado legislados en Estados Unidos, Alemania, Francia, Reino Unido, Italia, Holanda, Suecia y otros países, este artículo realiza una propuesta de política fiscal para su aplicación en España y Latinoamérica, consistente en legislar tres paquetes de medida de adr arbitrables en los tres estadios siguientes: a con antelación a la fase administrativa, b en la fase administrativa, c en la fase contencioso administrativa.

  1. Proximal Gastrojejunal Reconstruction after Pancreaticoduodenal Resection

    Directory of Open Access Journals (Sweden)

    M. Wayne

    2012-01-01

    Full Text Available Introduction. Reconstruction by proximal gastrojejunostomy, and distal biliary and pancreatic anastomoses is infrequently used after resection of the head of the pancreas because of fear of fistulas and cholangitis. Pancreaticoduodenectomy is being performed more frequently for cystic malignant and premalignant lesions. Because of this there is a need for endoscopic visualization and biopsy of the residual pancreatic duct, since multi-centricity is characteristic of some of these malignancies. Since endoscopic access of the bile duct and pancreatic duct is difficult and unsuccessful in 50–70% after B II or Roux Y reconstruction, we prospectively studied the merit and complications (early and late of proximal gastrojejunal (PGJ reconstruction after pancreaticoduodenal resection. Material and Methods. Thirty nine consecutive, non-radomized patients underwent pancreaticoduodenectomy and PGJ reconstruction over 14 mos. There were 21 males and 18 females. Results. 7 patients with IPMN have undergone repeat CT scanning for surveillance, with 3 requiring repeat EUS and ERCP. There were no technical difficulties accessing the pancreas or the pancreatic duct, supporting the PGJ reconstruction. Conclusion. Proximal gastrojejunal reconstruction following pancreaticoduodenal resection may be safely done with similar morbidity to traditional pancreaticojejunal reconstructions. PGJ reconstruction may be of greater value when direct visual access to the bile duct or pancreatic duct is necessary, and should be considered when doing resection for mucinous cysts or IPMN of the head of the pancreas.

  2. Bilateral, atraumatic, proximal tibiofibular joint instability.

    Science.gov (United States)

    Morrison, Troy D; Shaer, James A; Little, Jill E

    2011-01-01

    Dislocation of the tibiofibular joint is rare and usually results from a traumatic event. Only 1 case of atraumatic proximal tibiofibular joint instability in a 14-year-old girl has been reported in the literature, however this condition might occur more frequently than once thought. A wide range of treatment options exist for tibiofibular dislocations. Currently, the first choice is a conservative approach, and when this fails, surgical means such as resection of the fibula head, arthrodesis, and reconstruction are considered. However, no consensus exists on the most effective treatment. This article reports a unique case of bilateral, atraumatic, proximal tibia and fibular joint instability involving a 30-year-old man with a 20-year history of pain and laxity in the right knee. The patient had no trauma to his knees; he reported 2 immediate family members with similar complaints, which suggests that this case is likely congenital. After conservative approaches proved to be ineffective, the patient underwent capsular reconstruction using free autologous gracilis tendon. At 6-month postoperative follow-up, the patient was pain free with no locking and instability. He then underwent surgery on the left knee. At 1-year follow-up after the second surgery, the patient had no symptoms or restrictions in mobility. We provide an alternative surgical approach to arthrodesis and resection for the treatment of chronic proximal tibiofibular instability. In the treatment of chronic tibiofibular instability, we believe that reconstruction of the tibiofibular joint is a safe and effective choice. Copyright 2011, SLACK Incorporated.

  3. Calibrating animal-borne proximity loggers.

    Science.gov (United States)

    Rutz, Christian; Morrissey, Michael B; Burns, Zackory T; Burt, John; Otis, Brian; St Clair, James J H; James, Richard

    2015-06-01

    Growing interest in the structure and dynamics of animal social networks has stimulated efforts to develop automated tracking technologies that can reliably record encounters in free-ranging subjects. A particularly promising approach is the use of animal-attached 'proximity loggers', which collect data on the incidence, duration and proximity of spatial associations through inter-logger radio communication. While proximity logging is based on a straightforward physical principle - the attenuation of propagating radio waves with distance - calibrating systems for field deployment is challenging, since most study species roam across complex, heterogeneous environments.In this study, we calibrated a recently developed digital proximity-logging system ('Encounternet') for deployment on a wild population of New Caledonian crows Corvus moneduloides. Our principal objective was to establish a quantitative model that enables robust post hoc estimation of logger-to-logger (and, hence, crow-to-crow) distances from logger-recorded signal-strength values. To achieve an accurate description of the radio communication between crow-borne loggers, we conducted a calibration exercise that combines theoretical analyses, field experiments, statistical modelling, behavioural observations, and computer simulations.We show that, using signal-strength information only, it is possible to assign crow encounters reliably to predefined distance classes, enabling powerful analyses of social dynamics. For example, raw data sets from field-deployed loggers can be filtered at the analysis stage to include predominantly encounters where crows would have come to within a few metres of each other, and could therefore have socially learned new behaviours through direct observation. One of the main challenges for improving data classification further is the fact that crows - like most other study species - associate across a wide variety of habitats and behavioural contexts, with different signal

  4. Proximate chemical composition and fatty acid profiles of ...

    African Journals Online (AJOL)

    Proximate chemical composition and fatty acid profiles of Longissimus Proximate chemical composition and fatty acid profiles of Longissimus thoracis from pasture fed LHRH immunocastrated, castrated and intact Bos indicus bulls.

  5. Proximate Analysis and Total Lycopene Content of Some Tomato ...

    African Journals Online (AJOL)

    MBI

    2017-06-05

    Jun 5, 2017 ... Standard analytical techniques were employed to determine the proximate composition and lycopene content of three tomato cultivars namely: ... Keywords: Antioxidant, lycopene content, proximate composition, tomato cultivars. INTRODUCTION ..... from oranges, tomatoes and carrots. African. Journal of ...

  6. A Regularized Algorithm for the Proximal Split Feasibility Problem

    Directory of Open Access Journals (Sweden)

    Zhangsong Yao

    2014-01-01

    Full Text Available The proximal split feasibility problem has been studied. A regularized method has been presented for solving the proximal split feasibility problem. Strong convergence theorem is given.

  7. The regional dimension of intergenerational proximity in the Netherlands

    NARCIS (Netherlands)

    van der Pers, Marieke; Mulder, Clara H.

    Previous research has shown the impact of individual characteristics on intergenerational proximity but has largely ignored the regional dimension of such proximity. In this paper, we examine the regional variation in intergenerational proximity in the Netherlands. We address this issue by

  8. Quality Assessment and Proximate Analysis of Amaranthus hybridus ...

    African Journals Online (AJOL)

    The aim of this research is to determine the quality and proximate composition of Amaranthus hybridus, Celosia argentea, and Talinum triangulare obtained from open markets in Benin City, Nigeria. Microbiological and proximate analysis were carried out using standard methods. Results of the proximate analysis revealed ...

  9. Proximal femur geometry in the adult Kenyan femur and its ...

    African Journals Online (AJOL)

    Background: Numerous orthopaedic procedures are carried out on the proximal femur. For optimal hip function, these procedures must restore the anatomy of the proximal femur to as near normal as possible. There are currently no local studies that have described in detail the normal anatomy of the proximal femur and its ...

  10. Near-infrared triggered co-delivery of doxorubicin and quercetin by using gold nanocages with tetradecanol to maximize anti-tumor effects on MCF-7/ADR cells.

    Science.gov (United States)

    Zhang, Zhipeng; Xu, Shaohui; Wang, Yun; Yu, Yanna; Li, Fangzhou; Zhu, Hao; Shen, Yuanyuan; Huang, Shengtang; Guo, Shengrong

    2018-01-01

    Previously, combination chemotherapy of doxorubicin (DOX) and quercetin (QUR) was developed to improve antitumor effects and reverse multidrug resistance and several biocompatible nanocarriers, such as liposomes and micelles, were validated for their targeted delivery. In this study, we report a near-infrared (NIR)-responsive drug delivery system based on DOX and QUR co-loaded gold nanocages (AuNCs) with biotin modification. The system was simply fabricated by filling the hollow interiors of AuNCs with tetradecanol (TD), a phase-change material with a melting point of 39°C, to control the drug release. The main cause of multidrug resistance (MDR) of DOX is the overexpression of P-glycoprotein (P-gp), which can be inhibited by QUR. Thus the combination chemotherapy of DOX and QUR may provide a promising strategy for MDR. The in vitro cytotoxicity of DOX and QUR at several fixed mass ratios was carried out and showed that the combination index (CI) was the smallest at the ratio of 1:0.2, indicating that the best synergistic effect was achieved. The resultant nanocomplex (abbreviated as BPQD-AuNCs) exhibited fast release (80% released in 20min) and strong cytotoxicity against MCF-7/ADR cells (IC50, 1.5μg/mL) under NIR irradiation. Additionally, BPQD-AuNCs were found to generate a large amount of reactive oxygen species (ROS), to inhibit P-gp expression and ATP activity. Taken together, the results show that BPQD-AuNC is a prospective nano-delivery system for overcoming multidrug-resistant cancer. Copyright © 2017. Published by Elsevier Inc.

  11. Minimally Invasive Fixation for Proximal Humeral Fracture: A Review on the use of T2 Proximal Humeral Nail

    Directory of Open Access Journals (Sweden)

    Sze-Ling Iris Ngai

    2013-12-01

    Discussion and conclusion: With the proper surgical technique high union rate, good functional recovery, and low complication rate can be achieved by using T2 Proximal Humeral Nail in managing traumatic proximal humeral fracture.

  12. Delayed homicides and the proximate cause.

    Science.gov (United States)

    Lin, Peter; Gill, James R

    2009-12-01

    Delayed homicides result from complications of remote injuries inflicted by "the hands of another." The investigation of delayed homicides may be a challenge due to a number of factors including: failure to report the death to the proper authorities, lack of ready and adequate documentation of the original injury and circumstances, and jurisdictional differences between the places of injury and death. The certification of these deaths also requires the demonstration of a pathophysiologic link between the remote injury and death. In sorting through these issues, it is helpful to rely upon the definition of the proximate cause of death. Over a 2-year period in New York City, there were 1211 deaths certified as homicide of which 42 were due to injuries sustained greater than 1 year before death. The survival interval ranged from 1.3 to 43.2 years. The most common immediate causes of death were: infections (22), seizures (7), and intestinal obstructions/hernias (6). Common patterns of complications included infection following a gunshot wound of the spinal cord, seizure disorder due to blunt head trauma, and intestinal obstruction/hernia due to adhesions from an abdominal stab wound. Spinal cord injuries resulted in paraplegia in 14 instances and quadriplegia in 8. The mean survival interval for paraplegics was 20.3 years and 14.8 years for quadriplegics; infections were a frequent immediate cause of death in both groups, particularly infections due to chronic bladder catheterization. The definition of proximate cause originated with civil law cases and was later applied to death certification as the proximate cause of death. The gradual extinction of the "year and a day rule" for the limitation of bringing homicide charges in delayed deaths may result in more of these deaths going to trial. Medical examiners/coroners must be able to explain the reasoning behind these death certifications and maintain consistent standards for the certification of all delayed deaths due

  13. Laparoscopic proximal gastrectomy with oblique jejunogastrostomy.

    Science.gov (United States)

    Tanaka, Kimitaka; Ebihara, Yuma; Kurashima, Yo; Nakanishi, Yoshitsugu; Asano, Toshimichi; Noji, Takehiro; Murakami, Soichi; Nakamura, Toru; Tsuchikawa, Takahiro; Okamura, Keisuke; Shichinohe, Toshiaki; Hirano, Satoshi

    2017-05-10

    Proximal early gastric cancer is a good indication for totally laparoscopic proximal gastrectomy (TLPG) with double-tract reconstruction (DTR). However, when most of the dietary intake passes through the escape route of the jejunum, the functional benefits of proximal gastrectomy might be similar to those after total gastrectomy. Our DTR procedure was improved for easy passage through the remnant stomach. The purposes of this study were to present a novel technique for intracorporeal DTR using linear staplers after TLPG and to investigate surgical outcomes. DTR was performed using linear staplers only. A side-to-side jejunogastrostomy with twisting of both the remnant stomach and the anal jejunum was performed for the purpose of passing meals through the remnant stomach (an oblique jejunogastrostomy technique). The ten patients who underwent TLPG with DTR from January 2011 to August 2016 in Hokkaido University Hospital were retrospectively reviewed. Their clinicopathological characteristics and surgical and postoperative outcomes were collected and analyzed. The median duration of operation was 285 (range 146-440) min. No patients required blood transfusions. The number of dissected lymph nodes was 32 (range 22-56). There were no intraoperative complications, and no cases were converted to open surgery. All the patients were pT1N0M0 stage IA. No anastomotic leakage or complications were detected. Postoperative gastrography after reconstruction showed that contrast medium flowed mainly to the remnant stomach. The average percentage body weight loss was 14.0 ± 7.1% at 10 months. The average percentage decrease in serum hemoglobin was 5.4 ± 10.4% at 12 months. This novel technique for intracorporeal DTR provided a considerable advantage by the passage of dietary intake to the remnant stomach after LPG.

  14. Bicarbonate secretion by rabbit proximal colon.

    Science.gov (United States)

    Sullivan, S K; Smith, P L

    1986-10-01

    Stripped segments of proximal colon (1-6 cm distal to the ampulla caecalis coli) were studied in vitro in Ussing chambers under short-circuit conditions using the pH-stat technique. With glucose and HCO3-CO2 present in the serosal bathing solution only, proximal colon alkalinizes the luminal bathing solution at a rate of 2.1 +/- 0.2 mu eq X h-1 X cm-2 (n = 36). With HCO3-CO2 present in the luminal bathing solution alone, proximal colon does not significantly acidify or alkalinize the serosal bathing solution. Addition of glucose (10 mM) to the luminal bathing solution abolished luminal alkalinization. Removal of HCO3 and CO2 from the serosal bathing solution or replacement of O2 with N2 also abolished luminal alkalinization. Acetazolamide (0.1 mM) added to both bathing solutions did not alter the rate of luminal alkalinization. Ion-replacement studies revealed that the alkalinization process was highly dependent on the presence of Na in the bathing solutions and much less dependent on the presence of Cl. Furthermore, ouabain (0.1 mM) significantly reduced luminal alkalinization. As in rabbit ileum, serosal epinephrine (0.1 mM) did not alter luminal alkalinization but increased serosal alkalinization by a Na-dependent mechanism. These results suggest that luminal alkalinization results from a Na-dependent, active transcellular HCO3 transport process and that a Na-dependent HCO3 absorptive process is activated by adrenergic stimuli.

  15. Temporal Proximity Promotes Integration of Overlapping Events.

    Science.gov (United States)

    Zeithamova, Dagmar; Preston, Alison R

    2017-08-01

    Events with overlapping elements can be encoded as two separate representations or linked into an integrated representation, yet we know little about the conditions that promote one form of representation over the other. Here, we tested the hypothesis that the proximity of overlapping events would increase the probability of integration. Participants first established memories for house-object and face-object pairs; half of the pairs were learned 24 hr before an fMRI session, and the other half 30 min before the session. During scanning, participants encoded object-object pairs that overlapped with the initial pairs acquired on the same or prior day. Participants were also scanned as they made inference judgments about the relationships among overlapping pairs learned on the same or different day. Participants were more accurate and faster when inferring relationships among memories learned on the same day relative to those acquired across days, suggesting that temporal proximity promotes integration. Evidence for reactivation of existing memories-as measured by a visual content classifier-was equivalent during encoding of overlapping pairs from the two temporal conditions. In contrast, evidence for integration-as measured by a mnemonic strategy classifier from an independent study [Richter, F. R., Chanales, A. J. H., & Kuhl, B. A. Predicting the integration of overlapping memories by decoding mnemonic processing states during learning. Neuroimage, 124, 323-335, 2016]-was greater for same-day overlapping events, paralleling the behavioral results. During inference itself, activation patterns further differentiated when participants were making inferences about events acquired on the same day versus across days. These findings indicate that temporal proximity of events promotes integration and further influences the neural mechanisms engaged during inference.

  16. [Angle-stable intramedullary nailing of proximal humerus fractures with the PHN (proximal humeral nail)].

    Science.gov (United States)

    Blum, Jochen; Hansen, Matthias; Rommens, Pol Maria

    2009-09-01

    Stable fixation of two- and three-part fractures of the proximal humerus through minimally invasive operative technique and rapid bone healing as well as restoration of original anatomy. Early functional training with the goal of restoration of former mobility and daily activities. Unstabile two- and three-part fractures of the proximal humerus (AO classification: 11-A2, 11-A3, 11-B1, 11-B2, 11-B3). Subcapital nonunion of the humerus. Pathologic fractures. Pediatric fractures of the proximal humerus. Fractures of the proximal humerus types 11-C2 und 11-C3 according to the AO classification. Active local infection, e.g., after former operation. Closed reduction. Anterior acromial incision, splitting of the deltoid muscle and the rotator cuff. Opening of the medullary canal with the awl. Nail introduction. Spiral blade introduction in cannulated technique through stab incision. Distal interlocking through aiming device, angle-stable blocking of nail and blade through end cap. Postoperative fixation in Gilchrist sling until 2nd postoperative day; then physiotherapy respecting fracture type and stability, local swelling, patient's age and compliance, and concomitant injuries. 151 proximal humeral fractures were treated with a proximal humeral nail (PHN). 108 patients could be followed up 1 year postoperatively. Significant complications were perforation of the articular surface through bolts or blades (n = 8), implant-related pain (n = 10), fragment dislocation (n = 2), nonunion (n = 2), humeral head necrosis (n = 3), and superficial infection (n = 1). 1 year after the operation, the Constant-Murley Score showed a median value of 75.3 in the injured shoulder and of 89.9 in the uninjured shoulder. The DASH (Disability of the Arm, Shoulder and Hand) Score was 5.9 preoperatively and 9.3 at 1 year postoperatively. The worst results regarding the Constant-Murley Score as well as the DASH Score were found in C-type fractures.

  17. Impacted valgus fractures of the proximal humerus

    Directory of Open Access Journals (Sweden)

    Fabiano Rebouças Ribeiro

    2016-04-01

    Full Text Available Impacted valgus fractures of the proximal humerus are considered to be a special type fracture, since impaction of the humeral head on the metaphysis with maintenance of the posteromedial periosteum improves the prognosis regarding occurrences of avascular necrosis. This characteristic can also facilitate the reduction maneuver and increase the consolidation rate of these fractures, even in more complex cases. The studies included were obtained by searching the Bireme, Medline, PubMed, Cochrane Library and Google Scholar databases for those published between 1991 and 2013. The objective of this study was to identify the most common definitions, classifications and treatment methods used for these fractures in the orthopedic medical literature.

  18. Management of posttraumatic proximal interphalangeal joint contracture.

    Science.gov (United States)

    Houshian, Shirzad; Jing, Shan Shan; Chikkamuniyappa, Chandrasekar; Kazemian, Gholam Hussein; Emami-Moghaddam-Tehrani, Mohammad

    2013-08-01

    Chronic flexion contracture of the proximal interphalangeal (PIP) joint presents a common yet challenging problem to hand surgeons. Over the years, multiple treatment modalities have been described for this problem, producing limited results. Nonoperative treatment using serial casting and splints should be tried before attempting open surgical release, which should be done in selected patients. The use of external fixation for treating PIP contracture has been encouraging and can be a useful alterative. This review provides an update on the current management of PIP joint contractures and presents a flowchart of treatment to aid decision making. Copyright © 2013 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

  19. Proximal iliotibial band syndrome: case report

    Directory of Open Access Journals (Sweden)

    Guilherme Guadagnini Falotico

    2013-08-01

    Full Text Available OBJECTIVE: The overuse injuries in the hip joint occur commonly in sports practitioners and currently due to technical advances in diagnostic imaging, especially magnetic resonance imaging (MRI, are often misdiagnosed. Recently, a group of people were reported, all female, with pain and swelling in the pelvic region.T2-weighted MRI showed increased signal in the enthesis of the iliotibial band (ITB along the lower border of the iliac tubercle. We report a case of a 34 year old woman, non-professional runner, with pain at the iliac crest with no history of trauma and whose MRI was compatible with the proximal iliotibial band syndrome.

  20. Ontogeny of rabbit proximal tubule urea permeability

    Science.gov (United States)

    QUIGLEY, RAYMOND; LISEC, AMBER; BAUM, MICHEL

    2014-01-01

    Urea transport in the proximal tubule is passive and is dependent on the epithelial permeability. The present study examined the maturation of urea permeability (Purea) in in vitro perfused proximal convoluted tubules (PCT) and basolateral membrane vesicles (BLMV) from rabbit renal cortex. Urea transport was lower in neonatal than adult PCT at both 37 and 25°C. The PCT Purea was also lower in the neonates than the adults (37°C: 45.4 ± 10.8 vs. 88.5 ± 15.2 × 10−6 cm/s, P 0.05). The activation energy for PCT Purea was not different between the neonatal and adult groups. BLMV Purea was determined by measuring vesicle shrinkage, due to efflux of urea, using a stop-flow instrument. Neonatal BLMV Purea was not different from adult BLMV Purea at 37°C [1.14 ± 0.05 × 10−6 vs. 1.25 ± 0.05 × 10−6 cm/s; P = not significant (NS)] or 25°C (0.94 ± 0.06 vs. 1.05 ± 0.10 × 10−6 cm/s; P = NS). There was no effect of 250 μM phloretin, an inhibitor of the urea transporter, on Purea in either adult or neonatal BLMV. The activation energy for urea diffusion was also identical in the neonatal and adult BLMV. These findings in the BLMV are in contrast to the brush-border membrane vesicles (BBMV) where we have previously demonstrated that urea transport is lower in the neonate than the adult. Urea transport is lower in the neonatal proximal tubule than the adult. This is due to a lower rate of apical membrane urea transport, whereas basolateral urea transport is the same in neonates and adults. The lower Purea in neonatal proximal tubules may play a role in overall urea excretion and in developing and maintaining a high medullary urea concentration and thus in the ability to concentrate the urine during renal maturation. PMID:11353675

  1. Congenital anomalies and proximity to landfill sites.

    LENUS (Irish Health Repository)

    Boyle, E

    2004-01-01

    The occurrence of congenital anomalies in proximity to municipal landfill sites in the Eastern Region (counties Dublin, Kildare, Wicklow) was examined by small area (district electoral division), distance and clustering tendancies in relation to 83 landfills, five of which were major sites. The study included 2136 cases of congenital anomaly, 37,487 births and 1423 controls between 1986 and 1990. For the more populous areas of the region 50% of the population lived within 2-3 km of a landfill and within 4-5 km for more rural areas. In the area-level analysis, the standardised prevalence ratios, empirical and full Bayesian modelling, and Kulldorff\\'s spatial scan statistic found no association between the residential area of cases and location of landfills. In the case control analysis, the mean distance of cases and controls from the nearest landfill was similar. The odds ratios of cases compared to controls for increasing distances from all landfills and major landfills showed no significant difference from the baseline value of 1. The kernel and K methods showed no tendency of cases to cluster in relationship to landfills. In conclusion, congenital anomalies were not found to occur more commonly in proximity to municipal landfills.

  2. Scattering Effects in Proximity Effect Tunneling Spectroscopy.

    Science.gov (United States)

    Gai, Wei

    PETS (Proximity Effect Tunneling Spectroscopy) technique has been applied to Niobium/Yttrium and Niobium/Lutetium bilayers. We have determined electron - phonon interaction parameter lambda_{rm e -ph} is 0.55 for Yttrium and 0.67 for Lutetium. Spin fluctuations parameter lambda_{ rm S} is 0.20 for Yttrium and 0.33 for Lutetium. We found that the large spin fluctuations in Yttrium and Lutetium has responsibility to the absence of superconductivity in them. Our results have given a reasonable explanation of high superconducting transition temperature in them under high pressure. The large reflection coefficient and strong diffuse scattering at Nb/Y and Nb/Lu interface has been discovered and it should have strong influence on the transport properties of metallic superlattices. From the modeling study of elastic scattering in proximity effect tunnel junctions, we have explained why some conventional made high {rm T_{C}} superconducting tunnel junctions give ideal like characteristics in the gap region but variable strength phonon structures in the phonon region.

  3. Proteomics of Primary Cilia by Proximity Labeling.

    Science.gov (United States)

    Mick, David U; Rodrigues, Rachel B; Leib, Ryan D; Adams, Christopher M; Chien, Allis S; Gygi, Steven P; Nachury, Maxence V

    2015-11-23

    While cilia are recognized as important signaling organelles, the extent of ciliary functions remains unknown because of difficulties in cataloguing proteins from mammalian primary cilia. We present a method that readily captures rapid snapshots of the ciliary proteome by selectively biotinylating ciliary proteins using a cilia-targeted proximity labeling enzyme (cilia-APEX). Besides identifying known ciliary proteins, cilia-APEX uncovered several ciliary signaling molecules. The kinases PKA, AMPK, and LKB1 were validated as bona fide ciliary proteins and PKA was found to regulate Hedgehog signaling in primary cilia. Furthermore, proteomics profiling of Ift27/Bbs19 mutant cilia correctly detected BBSome accumulation inside Ift27(-/-) cilia and revealed that β-arrestin 2 and the viral receptor CAR are candidate cargoes of the BBSome. This work demonstrates that proximity labeling can be applied to proteomics of non-membrane-enclosed organelles and suggests that proteomics profiling of cilia will enable a rapid and powerful characterization of ciliopathies. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Empathy: Its ultimate and proximate bases.

    Science.gov (United States)

    Preston, Stephanie D; de Waal, Frans B M

    2002-02-01

    There is disagreement in the literature about the exact nature of the phenomenon of empathy. There are emotional, cognitive, and conditioning views, applying in varying degrees across species. An adequate description of the ultimate and proximate mechanism can integrate these views. Proximately, the perception of an object's state activates the subject's corresponding representations, which in turn activate somatic and autonomic responses. This mechanism supports basic behaviors (e.g., alarm, social facilitation, vicariousness of emotions, mother-infant responsiveness, and the modeling of competitors and predators) that are crucial for the reproductive success of animals living in groups. The Perception-Action Model (PAM), together with an understanding of how representations change with experience, can explain the major empirical effects in the literature (similarity, familiarity, past experience, explicit teaching, and salience). It can also predict a variety of empathy disorders. The interaction between the PAM and prefrontal functioning can also explain different levels of empathy across species and age groups. This view can advance our evolutionary understanding of empathy beyond inclusive fitness and reciprocal altruism and can explain different levels of empathy across individuals, species, stages of development, and situations.

  5. Proximal femoral osteotomy in cerebral palsy.

    Science.gov (United States)

    Tylkowski, C M; Rosenthal, R K; Simon, S R

    1980-09-01

    The purpose of this study was to examine the results of the proximal femoral osteotomy for the management of hip deformity in 32 children, aged 4 to 15 years. Twenty-two bilateral and ten unilateral procedures were performed. The indications for surgery were subluxation in 16, dislocation in two, and intoeing and femoral anteversion in 14. The average follow-up was two years and 11 months. CE angle of Wiberg, acetabular index and neck shaft angle were evaluated. The average time to regain preoperative ambulatory status was six months with intensive physical therapy. In osteotomies performed for subluxation, dislocation did not occur; roentgenographic indices showed variability in the degree of subluxation. Osteotomy performed in children older than 8 years of age produced no evidence of acetabular remodeling. THere was no recurrence with osteotomies for dislocation. In those patients with internal rotation gait, improvement resulted. Complications were few and minor. Hip dislocation in children with progressive subluxation, in spite of previous soft-tissue releases, is preventable by proximal femoral osteotomy. The inability of the roentgenographic indices to quantitate the increased stability indicates the procedure's major effect is to realign muscle forces about the hip. Treatment of the intoeing gait produced improvement of rotational deformity.

  6. Obesity and supermarket access: proximity or price?

    Science.gov (United States)

    Drewnowski, Adam; Aggarwal, Anju; Hurvitz, Philip M; Monsivais, Pablo; Moudon, Anne V

    2012-08-01

    We examined whether physical proximity to supermarkets or supermarket price was more strongly associated with obesity risk. The Seattle Obesity Study (SOS) collected and geocoded data on home addresses and food shopping destinations for a representative sample of adult residents of King County, Washington. Supermarkets were stratified into 3 price levels based on average cost of the market basket. Sociodemographic and health data were obtained from a telephone survey. Modified Poisson regression was used to test the associations between obesity and supermarket variables. Only 1 in 7 respondents reported shopping at the nearest supermarket. The risk of obesity was not associated with street network distances between home and the nearest supermarket or the supermarket that SOS participants reported as their primary food source. The type of supermarket, by price, was found to be inversely and significantly associated with obesity rates, even after adjusting for individual-level sociodemographic and lifestyle variables, and proximity measures (adjusted relative risk=0.34; 95% confidence interval=0.19, 0.63) Improving physical access to supermarkets may be one strategy to deal with the obesity epidemic; improving economic access to healthy foods is another.

  7. Demonstration of automated proximity and docking technology

    Science.gov (United States)

    Anderson, Robert L.; Tsugawa, Roy K.; Bryan, Thomas C.

    1991-01-01

    Automated spacecraft docking operations are being performed using a full scale motion based simulator and an optical sensor. This presentation will discuss the work in progress at TRW and MSFC facilities to study the problem of automated proximity and docking operations. The docking sensor used in the MSFC Optical Sensor and simulation runs are performed using the MSFC Flat Floor Facility. The control algorithms and six degrees of freedom (6DOF) simulation software were developed at TRW and integrated into the MSFC facility. Key issues being studied are the quantification of docking sensor requirements and operational constraints necessary to perform automated docking maneuvers, control algorithms capable of performing automated docking in the presence of sensitive and noisy sensor data, and sensor technologies for automated proximity and docking operations. As part of this study the MSFC sensor characteristics were analyzed and modeled so that off line simulation runs can be performed for control algorithm testing. Our goal is to develop and demonstrate full 6DOF docking capabilities with actual sensors on the MSFC motion based simulator. We present findings from actual docking simulation runs which show sensor and control loop performance as well as problem areas which require close attention. The evolution of various control algorithms using both phase plane and Clohessy-Wiltshire techniques are discussed. In addition, 6DOF target acquisition and control strategies are described.

  8. Further contribution to the knowledge of Ityphilus calinus Chamberlin, 1957, a poorly known ballophilid centipede from Colombia, with description of Ityphilus bonatoi, a new diminutive geophilomorph species from Brazil (Myriapoda: Chilopoda, Geophilomorpha).

    Science.gov (United States)

    Pereira, Luis Alberto

    2013-01-01

    Ityphilus calinus Chamberlin, 1957 (Chilopoda: Geophilomorpha, Ballophilidae), a poorly known centipede from Cauca Valley, Colombia, is herein redescribed and illustrated after the male holotype, revealing the condition of the forcipular tarsungulum (which is completely smooth), also giving new data on many other morphological features of specific value until now unknown. A new diminutive species named Ityphilus bonatoi sp. nov. is herein proposed after the holotype female from Rio de Janeiro State, Brazil. The new species is characterized by having the internal edge of the forcipular tarsungulum serrate; among the other Neotropical members of the genus having the same trait, it only shares with I. donatellae Pereira, 2012 (from Central Amazon) a very small body size and a low number of leg-bearing segments. The new species represents the first record of the genus Ityphilus from the Atlantic Rainforest biome, and the southernmost representative of the genus in the Continent. A key for identification of the Neotropical species currently included in Ityphilus is also given.

  9. Conservadorismo contábil e timeliness: evidências empíricas nas demonstrações contábeis de empresas Brasileiras com ADRs negociados na bolsa de Nova Iorque Accounting conservatism and timeliness: empirical evidence in financial statements of Brazilian companies with ADRs traded on the New York stock exchange

    Directory of Open Access Journals (Sweden)

    Luis Sérgio Ribeiro dos Santos

    2008-12-01

    Full Text Available Este estudo investiga o nível de utilização do conservadorismo e da oportunidade (timeliness da informação contábil nas demonstrações contábeis de empresas brasileiras com ADRs negociados na Bolsa de Nova Iorque. Essas empresas apresentam suas demonstrações contábeis tanto conforme o modelo contábil brasileiro quanto segundo o norte-americano, atendendo às exigências da Securities and Exchange Commission (SEC. Os dados foram coletados compreendendo o período de 1999 a 2004 e aplicou-se o modelo de Basu (BASU, 1997 para a avaliação da oportunidade e do conservadorismo da informação contábil. Os resultados encontrados indicam que (1 não há diferenças no nível de utilização do conservadorismo e (2 o lucro contábil segundo o modelo brasileiro seria mais oportuno do que o norte-americano. Assim, as evidências contribuem para o atual debate sobre a inserção do Brasil no atual estágio de convergência de demonstrações contábeis.This study investigates the timeliness and the degree of conservatism in fi nancial statements disclosed by Brazilian companies with ADRs traded on the New York Stock Exchange. According to the Securities and Exchange Commission (SEC, those companies must disclose accounting information according to the Brazilian Generally Accepted Accounting Principles (BR GAAP as well as the United States Generally Accepted Accounting Principles (US GAAP. The data were collected between 1999 and 2004 and the Basu Model (BASU, 1997 was applied to evaluate earnings timeliness and conservatism. The results are: (1 there is no difference in earnings conservatism and (2 earnings according to the BR GAAP are more timely than those according to the US GAAP. The evidence contributes to the current debate about the role of Brazil in the current stage of the convergence process.

  10. Pathological fractures of the proximal humerus treated with a proximal humeral locking plate and bone cement.

    Science.gov (United States)

    Siegel, H J; Lopez-Ben, R; Mann, J P; Ponce, B A

    2010-05-01

    Bone loss secondary to primary or metastatic lesions of the proximal humerus remains a challenging surgical problem. Options include preservation of the joint with stabilisation using internal fixation or resection of the tumour with prosthetic replacement. Resection of the proximal humerus often includes the greater tuberosity and adjacent diaphysis, which may result in poor function secondary to loss of the rotator cuff and/or deltoid function. Preservation of the joint with internal fixation may reduce the time in hospital and peri-operative morbidity compared with joint replacement, and result in a better functional outcome. We included 32 patients with pathological fractures of the proximal humerus in this study. Functional and radiological assessments were performed. At a mean follow-up of 17.6 months (8 to 61) there was no radiological evidence of failure of fixation. The mean revised musculoskeletal Tumour Society functional score was 94.6% (86% to 99%). There was recurrent tumour requiring further surgery in four patients (12.5%). Of the 22 patients who were employed prior to presentation all returned to work without restrictions. The use of a locking plate combined with augmentation with cement extends the indications for salvage of the proximal humerus with good function in patients with pathological and impending pathological fractures.

  11. Challenges of Pluralistic Societies with Dissimilar Cultural Identities and Religious Legal Traditions: ADR and the Role of Religious Mediation and Arbitration

    Directory of Open Access Journals (Sweden)

    Gloria M. Morán García

    2017-10-01

    Abstract: Most of juridical systems are historically developed from the interaction of two main legal principles: the principle of personality and the principle of territoriality. Roman Law is one of the best examples of it; its legacy channeled the growth and coexistence of religious and secular jurisdictions in the Germanic kingdoms of Western Europe. Under the principle of personality of laws, bonding individuals to their cultural or religious communities, legal pluralism was the common grounds from the Antiquity to the pre-Modern era. However, as a result of the religious wars in the Holy Roman Empire between Catholics and Protestants in the 16th and the 17th centuries, the Westphalian state model reinforced a territorial religious jurisdiction under the principle cuius regio eius religio, allowing the ruler to impose his religion on his subjects. The Muslim legal tradition developed, as well, plural juridical systems from the Dhimma System. One of them was the Ottoman Millet system that was adapted from the colonial era to the most of Middle East nation-states as a bonding personal religious law applied to non-Muslim communities. The secular paradigm of the Rule of Law, centralizing and reinforcing state and federal legislative powers, is implemented in Europe and her former colonies in the 19th century under the nation-state constitutional model, expanding worldwide the principles of territoriality and citizenship. As a result, religious legal systems are progressively confined to the private sphere. However, the secular paradigm is confronted gradually by a new development of legal pluralism, mainly as an effect of an extensive increment of global migrations; Halakha or Jewish Law, Canon Law or Catholic Law, Sharia or Islamic Law, are gaining strength as formal or informal religious ADR under the principle of Religious Freedom. Religious legal systems are becoming an innovative tool of mediation, conciliation, and arbitration accepted by some secular

  12. Digital camera resolution and proximal caries detection.

    Science.gov (United States)

    Prapayasatok, S; Janhom, A; Verochana, K; Pramojanee, S

    2006-07-01

    To evaluate the diagnostic accuracy of proximal caries detection from digitized film images captured by a digital camera at different resolution settings. Twenty-five periapical radiographs of 50 premolar and 25 molar teeth were photographed using a digital camera, Sony Cyber-shot, DSC-S75 at three different resolution settings: 640 x 480, 1280 x 960 and 1600 x 1200. Seventy-five digital images were transferred to a computer, saved and opened using ACDSee software. In addition, a PowerPoint slide was made from each digital image. Five observers scored three groups of images (the films, the displayed 1:1 digital images on the ACDSee software, and the PowerPoint slides) for the existence of proximal caries using a 5-point confidence scale, and the depth of caries on a 4-point scale. Ground sections of the teeth were used as the gold standard. Az values under the receiver operating characteristic (ROC) curve of each group of images and at different resolutions were compared using the Friedman and Wilcoxon signed rank tests. Mean different values between the lesions' depth interpreted by the observers and that of the gold standard were analysed. Films showed the highest Az values. Only the 1280 x 960 images on the ACDSee software showed no significant difference of the Az value from the films (P=0.28). The digital images from three resolution settings on the PowerPoint slides showed no significant differences, either among each other or between them and the films. For caries depth, the 1280 x 960 images showed lower values of mean difference in enamel lesions compared with the other two resolution groups. This study showed that in order to digitize conventional films, it was not necessary to use the highest camera resolution setting to achieve high diagnostic accuracy for proximal caries detection. The 1280 x 960 resolution setting of the digital camera demonstrated comparable diagnostic accuracy with film and was adequate for digitizing radiographs for caries

  13. The non-operative resin treatment of proximal caries lesions.

    Science.gov (United States)

    Ekstrand, Kim; Martignon, Stefania; Bakhshandeh, Azam; Ricketts, David N J

    2012-11-01

    Epidemiological data show that the prevalence of caries on proximal surfaces in need of operative treatment is very high around the world, both in the primary and the permanent dentition. This article presents two new treatment methods: proximal sealing and proximal infiltration. The indications are progressing proximal caries lesions, radiographically with a depth around the enamel-dentine junction. A small number of studies regarding the effect of sealing and infiltration on proximal caries versus the use of fluoride varnish, placebo treatment and flossing instructions have been carried out. About half of the studies disclose a not significant difference between test and control treatment. In the other half, the therapeutic effect is significant and corresponds to about 30% reduction in lesion progression. However, longitudinal studies of longer duration are lacking. Proximal sealing and proximal infiltration may have a place in the treatment of non-cavitated proximal lesions. Proximal caries is a problem in both primary and permanent dentitions. Proximal sealants or lesion infiltration are possible treatments.

  14. Rehabilitation and Prevention of Proximal Hamstring Tendinopathy.

    Science.gov (United States)

    Beatty, Nicholas R; Félix, Ioonna; Hettler, Jessica; Moley, Peter J; Wyss, James F

    Proximal hamstring tendinopathy (PHT) comprises a small but significant portion of hamstring injuries in athletes, especially runners. PHT is a chronic condition that is clinically diagnosed but can be supported with imaging. The main presenting complaint is pain in the lower gluteal or ischial region that may or may not radiate along the hamstrings in the posterior thigh. There is little scientific evidence on which to base the rehabilitation management of PHT. Treatment is almost always conservative, with a focus on activity modification, addressing contributing biomechanical deficiencies, effective tendon loading including eccentric training, and ultrasound-guided interventional procedures which may facilitate rehabilitation. Surgery is limited to recalcitrant cases or those involving concomitant high-grade musculotendinous pathology. The keys to PHT management include early and accurate diagnosis, optimal rehabilitation to allow for a safe return to preinjury activity level, and preventative strategies to reduce risk of reinjury.

  15. DC Proximal Newton for Nonconvex Optimization Problems.

    Science.gov (United States)

    Rakotomamonjy, Alain; Flamary, Rémi; Gasso, Gilles

    2016-03-01

    We introduce a novel algorithm for solving learning problems where both the loss function and the regularizer are nonconvex but belong to the class of difference of convex (DC) functions. Our contribution is a new general purpose proximal Newton algorithm that is able to deal with such a situation. The algorithm consists in obtaining a descent direction from an approximation of the loss function and then in performing a line search to ensure a sufficient descent. A theoretical analysis is provided showing that the iterates of the proposed algorithm admit as limit points stationary points of the DC objective function. Numerical experiments show that our approach is more efficient than the current state of the art for a problem with a convex loss function and a nonconvex regularizer. We have also illustrated the benefit of our algorithm in high-dimensional transductive learning problem where both the loss function and regularizers are nonconvex.

  16. Proximity Effects in Superconductor-Graphene Junctions

    Science.gov (United States)

    Cuellar, Fabian A.; Perconte, David; Martin, Marie-Blandine; Dlubak, Bruno; Piquemail, Maelis; Bernard, Rozenn; Trastoy, Juan; Moreau-Luchaire, Constance; Seneor, Pierre; Villegas, Javier E.; Kidambi, Piran; Hofmann, Stephan; Robertson, John

    2015-03-01

    Superconducting proximity effects are of particular interest in graphene: because of its band structure, an unconventional (specular) Andreev reflection is expected. In this context, high-Tc superconductor-graphene junctions are especially attractive. In these, the size of the superconducting energy-gap may exceed the graphene doping inhomogeneities around the Dirac point, which should favor the observation of the specular Andreev reflection. Yet, the fabrication of high-Tc superconductor-graphene junctions is challenging: the usual growth and lithography processes in both materials are incompatible. We report here on a fabrication method that allow us to fabricate planar cuprate superconductor-graphene junctions, which we characterize via conductance spectroscopy. We analyze the features in the conductance spectra as a function of graphene doping, and discuss them in the framework of the Andreev reflection. Work supported by Labex Nanosaclay.

  17. Phonon engineering in proximity enhanced superconductor heterostructures.

    Science.gov (United States)

    Tang, Yong-Chao; Kwon, Sangil; Mohebbi, Hamid R; Cory, David G; Miao, Guo-Xing

    2017-06-27

    In this research, we tailor the phonon density of states (DOS) in thin superconducting films to suppress quasiparticle losses. We examine a model system of a proximity-enhanced three-layered Al/Nb/Al heterostructure and show that the local quantized phonon spectrum of the ultrathin Al cladding layers in the heterostructure has a pronounced effect on the superconducting resonator's quality factors. Instead of a monotonic increase of quality factors with decreasing temperatures, we observe the quality factor reaches a maximum at 1.2 K in 5/50/5 nm Al/Nb/Al microstrip resonators, because of a quantized phonon ladder. The phonon DOS may be engineered to enhance the performance of quantum devices.

  18. Structure and substrate specificity of the pyrococcal coenzyme A disulfide reductases/polysulfide reductases (CoADR/Psr): implications for S(0)-based respiration and a sulfur-dependent antioxidant system in Pyrococcus.

    Science.gov (United States)

    Herwald, Sanna; Liu, Albert Y; Zhu, Brian E; Sea, Kevin W; Lopez, Karlo M; Sazinsky, Matthew H; Crane, Edward J

    2013-04-23

    FAD and NAD(P)H-dependent coenzyme A disulfide reductases/polysulfide reductases (CoADR/Psr) have been proposed to be important for the reduction of sulfur and disulfides in the sulfur-reducing anaerobic hyperthermophiles Pyrococcus horikoshii and Pyrococcus furiosus; however, the form(s) of sulfur that the enzyme actually reduces are not clear. Here we determined the structure for the FAD- and coenzyme A-containing holoenzyme from P. horikoshii to 2.7 Å resolution and characterized its substrate specificity. The enzyme is relatively promiscuous and reduces a range of disulfide, persulfide, and polysulfide compounds. These results indicate that the likely in vivo substrates are NAD(P)H and di-, poly-, and persulfide derivatives of coenzyme A, although polysulfide itself is also efficiently reduced. The role of the enzyme in the reduction of elemental sulfur (S(8)) in situ is not, however, ruled out by these results, and the possible roles of this substrate are discussed. During aerobic persulfide reduction, rapid recycling of the persulfide substrate was observed, which is proposed to occur via sulfide oxidation by O(2) and/or H(2)O(2). As expected, this reaction disappears under anaerobic conditions and may explain observations by others that CoADR is not essential for S(0) respiration in Pyrococcus or Thermococcus but appears to participate in oxidative defense in the presence of S(0). When compared to the homologous Npsr enzyme from Shewanella loihica PV-4 and homologous enzymes known to reduce CoA disulfide, the phCoADR structure shows a relatively restricted substrate channel leading into the sulfur-reducing side of the FAD isoalloxazine ring, suggesting how this enzyme class may select for specific disulfide substrates.

  19. Mouse model of proximal tubule endocytic dysfunction.

    Science.gov (United States)

    Weyer, Kathrin; Storm, Tina; Shan, Jingdong; Vainio, Seppo; Kozyraki, Renata; Verroust, Pierre J; Christensen, Erik I; Nielsen, Rikke

    2011-11-01

    Several studies have indicated the central role of the megalin/cubilin multiligand endocytic receptor complex in protein reabsorption in the kidney proximal tubule. However, the poor viability of the existing megalin-deficient mice precludes further studies and comparison of homogeneous groups of mice. Megalin- and/or cubilin-deficient mice were generated using a conditional Cre-loxP system, where the Cre gene is driven by the Wnt4 promoter. Kidney tissues from the mice were analysed for megalin and cubilin expression by quantitative reverse transcription-polymerase chain reaction, western blotting and immunohistochemistry. Renal albumin uptake was visualized by immunohistochemistry. Twenty-four-hour urine samples were collected in metabolic cages and analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and western blotting. Urinary albumin/creatinine ratios were measured by ELISA and the alkaline picrate method. The Meg(lox/lox);Cre(+), Cubn(lox/lox);Cre(+) and Meg(lox/lox), Cubn(lox/lox);Cre(+) mice were all viable, fertile and developed normal kidneys. Megalin and/or cubilin expression, assessed by immunohistology and western blotting, was reduced by >89%. Consistent with this observation, the mice excreted megalin and cubilin ligands such as transferrin and albumin in addition to low-molecular weight proteins. We further show that megalin/cubilin double-deficient mice excrete albumin with an average of 1.45 ± 0.54 mg/day, suggesting a very low albumin concentration in the glomerular ultrafiltrate. We report here the efficient genetic ablation of megalin, cubilin or both, using a Cre transgene driven by the Wnt4 promoter. The viable megalin/cubilin double-deficient mice now allow for detailed large-scale group analysis, and we anticipate that the mice will be of great value as an animal model for proximal tubulopathies with disrupted endocytosis.

  20. Proximal and distal muscle fatigue differentially affect movement coordination.

    Science.gov (United States)

    Cowley, Jeffrey C; Gates, Deanna H

    2017-01-01

    Muscle fatigue can cause people to change their movement patterns and these changes could contribute to acute or overuse injuries. However, these effects depend on which muscles are fatigued. The purpose of this study was to determine the differential effects of proximal and distal upper extremity muscle fatigue on repetitive movements. Fourteen subjects completed a repetitive ratcheting task before and after a fatigue protocol on separate days. The fatigue protocol either fatigued the proximal (shoulder flexor) or distal (finger flexor) muscles. Pre/Post changes in trunk, shoulder, elbow, and wrist kinematics were compared to determine how proximal and distal fatigue affected multi-joint movement patterns and variability. Proximal fatigue caused a significant increase (7°, p fatigue caused small but significant changes in trunk angles (2°, p fatigue protocols (p fatigue at either proximal or distal joints. The identified differences between proximal and distal muscle fatigue adaptations could facilitate risk assessment of occupational tasks.

  1. Proximal and distal muscle fatigue differentially affect movement coordination

    Science.gov (United States)

    Cowley, Jeffrey C.

    2017-01-01

    Muscle fatigue can cause people to change their movement patterns and these changes could contribute to acute or overuse injuries. However, these effects depend on which muscles are fatigued. The purpose of this study was to determine the differential effects of proximal and distal upper extremity muscle fatigue on repetitive movements. Fourteen subjects completed a repetitive ratcheting task before and after a fatigue protocol on separate days. The fatigue protocol either fatigued the proximal (shoulder flexor) or distal (finger flexor) muscles. Pre/Post changes in trunk, shoulder, elbow, and wrist kinematics were compared to determine how proximal and distal fatigue affected multi-joint movement patterns and variability. Proximal fatigue caused a significant increase (7°, p fatigue caused small but significant changes in trunk angles (2°, p fatigue protocols (p fatigue at either proximal or distal joints. The identified differences between proximal and distal muscle fatigue adaptations could facilitate risk assessment of occupational tasks. PMID:28235005

  2. Spatial Proximity and Intercompany Communication: Myths and Realities

    OpenAIRE

    Aguilera, Anne; Lethiais, Virginie; Alain RALLET

    2015-01-01

    Spatial proximity is credited with numerous virtues in the economic literature. In particular, for a company to be located near other companies is seen as conducive to the development of business relations. Spatial proximity is also considered to contribute to the quality and efficiency of these relations by facilitating face-to-face meetings that foster the exchange of complex knowledge and, in particular, the emergence of innovation. This article explores the notion of spatial proximity in ...

  3. Diagnosis of Proximal Caries in Primary Molars with DIAGNOdent pen

    OpenAIRE

    Ermler, Romy

    2010-01-01

    Proximal surfaces, together with fissures, are the areas where most primary caries occur. Due to the anatomy of the deciduous molars, proximal caries cannot be detected at an early stage in crowded teeth by simply using a mirror and probe. Therefore, additional methods to find early proximal caries have to be used. KaVo uses laser fluorescence to detect caries. Originally, the DIAGNOdent devices were able to detect only occlusal caries (56, 61, 62, 65, 66). New results are now also available ...

  4. Inexact proximal Newton methods for self-concordant functions

    DEFF Research Database (Denmark)

    Li, Jinchao; Andersen, Martin Skovgaard; Vandenberghe, Lieven

    2016-01-01

    with an application to L1-regularized covariance selection, in which prior constraints on the sparsity pattern of the inverse covariance matrix are imposed. In the numerical experiments the proximal Newton steps are computed by an accelerated proximal gradient method, and multifrontal algorithms for positive definite......We analyze the proximal Newton method for minimizing a sum of a self-concordant function and a convex function with an inexpensive proximal operator. We present new results on the global and local convergence of the method when inexact search directions are used. The method is illustrated...

  5. Multimodal Biometrics Recognition by Dimensionality Diminution Method

    Directory of Open Access Journals (Sweden)

    Suvarnsing Bhable

    2015-12-01

    Full Text Available Multimodal biometric system utilizes two or more character modalities, e.g., face, ear, and fingerprint, Signature, plamprint to improve the recognition accuracy of conventional unimodal methods. We propose a new dimensionality reduction method called Dimension Diminish Projection (DDP in this paper. DDP can not only preserve local information by capturing the intra-modal geometry, but also extract between-class relevant structures for classification effectively. Experimental results show that our proposed method performs better than other algorithms including PCA, LDA and MFA.

  6. Diminution in energy expenditure during lactation.

    OpenAIRE

    Illingworth, P J; Jung, R. T.; Howie, P W; P; Leslie; Isles, T E

    1986-01-01

    Energy expenditure at rest and in response to a meal and to an infusion of noradrenaline was measured in 12 lactating women and compared with that in seven bottle feeding women and seven non-pregnant, non-lactating controls. The energy response of the lactating women was remeasured after lactation stopped. During lactation the resting metabolic rate was unaltered but there was a reduced response to infusion of noradrenaline and to a meal, which increased to normal control values after lactati...

  7. Imaging of rectus femoris proximal tendinopathies

    Energy Technology Data Exchange (ETDEWEB)

    Pesquer, Lionel; Poussange, Nicolas; Meyer, Philippe; Dallaudiere, Benjamin; Feldis, Matthieu [Clinique du Sport de Bordeaux, Centre d' Imagerie Osteo-articulaire, Merignac (France); Sonnery-Cottet, Bertrand [Groupe Ramsay Generale de Sante - Hopital Prive Jean Mermoz, Centre Orthopedique Santy, Lyon (France); Graveleau, Nicolas [Clinique du Sport de Bordeaux, Centre de Chirurgie Orthopedique et Sportive, Merignac (France)

    2016-07-15

    The rectus femoris is the most commonly injured muscle of the anterior thigh among athletes, especially soccer players. Although the injury pattern of the muscle belly is well documented, less is known about the anatomy and specific lesions of the proximal tendons. For each head, three distinctive patterns may be encountered according to the location of the injury, which can be at the enthesis, within the tendon, or at the musculotendinous junction. In children, injuries correspond most commonly to avulsion of the anteroinferior iliac spine from the direct head and can lead to subspine impingement. Calcific tendinitis and traumatic tears may be encountered in adults. Recent studies have shown that traumatic injuries of the indirect head may be underdiagnosed and that injuries of both heads may have a surgical issue. Finally, in the case of tears, functional outcome and treatment may vary if the rupture involves one or both tendons and if the tear is partial or complete. Thus, it is mandatory for the radiologist to know the different ultrasound and magnetic resonance imaging (MRI) patterns of these lesions in order to provide accurate diagnosis and treatment. The purpose of this article is to recall the anatomy of the two heads of rectus femoris, describe a reliable method of assessment with ultrasound and MRI and know the main injury patterns, through our own experience and literature review. (orig.)

  8. Proximate industrial activity and psychological distress

    Science.gov (United States)

    Downey, Liam; Jackson, James S.; Merrill, J. Bryce; Saint Onge, Jarron M.; Williams, David R.

    2009-01-01

    This paper examines the role that gender, occupational status, and family status play in moderating the effect of industrial activity on the psychological well-being of nearby residents. Using a unique spatial assessment of industrial activity and an environmental risk/social stressor framework in conjunction with individual-level data from the Detroit Area Study (DAS) and demographic data from the U.S. census, we find that residents of neighborhoods in close proximity to industrial activity report elevated levels of psychological distress compared to residents of neighborhoods removed from this type of activity. These influences are more pronounced among women but gender differences are also contingent upon occupational and family statuses. We show that specific combinations of work and family statuses make persons particularly vulnerable to the influence of this environmental stressor and women are two and a half times more likely than men to have these vulnerable statuses. This study makes an important contribution to the environmental health literature because it reminds researchers of the fundamental influence of social roles when examining the link between environmental risks and mental health. PMID:19444334

  9. [Ophthalmologists in the proximity of Adolf Hitler].

    Science.gov (United States)

    Rohrbach, J M

    2012-10-01

    Adolf Hitler met or at least knew about 5 ophthalmologists. The chair of ophthalmology in Berlin, Walther Löhlein, personally examined Hitler's eyes at least two times. The chair of ophthalmology in Breslau, Walter Dieter, developed "air raid protection spectacles" with the aid of high representatives of the NS-system and probably Adolf Hitler himself. Heinrich Wilhelm Kranz became rector of the universities of Giessen and Frankfurt/Main. He was known as a very strict advocate of the NS-race hygiene. Werner Zabel made plans for Hitler's diet and tried to interfere with Hitler's medical treatment. Finally, Hellmuth Unger was an influential representative of the medical press and a famous writer. Three of his novels with medical topics were made into a film which Hitler probably saw. Hitler had, so to say, a small "ophthalmological proximity" which, however, did not play a significant role for himself or the NS-state. © Georg Thieme Verlag KG Stuttgart · New York.

  10. Proximity coupling in superconductor-graphene heterostructures.

    Science.gov (United States)

    Lee, Gil-Ho; Lee, Hu-Jong

    2018-02-16

    This review discusses the electronic properties and the prospective research directions of superconductor-graphene heterostructures. The basic electronic properties of graphene are introduced to highlight the unique possibility of combining two seemingly unrelated physics, superconductivity and relativity. We then focus on graphene-based Josephson junctions, one of the most versatile superconducting quantum devices. The various theoretical methods that have been developed to describe graphene Josephson junctions are examined, together with their advantages and limitations, followed by a discussion on the advances in device fabrication and the relevant length scales. The phase-sensitive properties and phase-particle dynamics of graphene Josephson junctions are examined to provide an understanding of the underlying mechanisms of Josephson coupling via graphene. Thereafter, microscopic transport of correlated quasiparticles produced by Andreev reflections at superconducting interfaces and their phase-coherent behaviors are discussed. Quantum phase transitions studied with graphene as an electrostatically tunable two-dimensional platform are reviewed. The interplay between proximity-induced superconductivity and the quantum-Hall phase is discussed as a possible route to study topological superconductivity and non-Abelian physics. Finally, a brief summary on the prospective future research directions is given. © 2018 IOP Publishing Ltd.

  11. Semiconductor detectors with proximity signal readout

    Energy Technology Data Exchange (ETDEWEB)

    Asztalos, Stephen J. [XIA, LLC, Hayward, CA (United States)

    2014-01-30

    Semiconductor-based radiation detectors are routinely used for the detection, imaging, and spectroscopy of x-rays, gamma rays, and charged particles for applications in the areas of nuclear and medical physics, astrophysics, environmental remediation, nuclear nonproliferation, and homeland security. Detectors used for imaging and particle tracking are more complex in that they typically must also measure the location of the radiation interaction in addition to the deposited energy. In such detectors, the position measurement is often achieved by dividing or segmenting the electrodes into many strips or pixels and then reading out the signals from all of the electrode segments. Fine electrode segmentation is problematic for many of the standard semiconductor detector technologies. Clearly there is a need for a semiconductor-based radiation detector technology that can achieve fine position resolution while maintaining the excellent energy resolution intrinsic to semiconductor detectors, can be fabricated through simple processes, does not require complex electrical interconnections to the detector, and can reduce the number of required channels of readout electronics. Proximity electrode signal readout (PESR), in which the electrodes are not in physical contact with the detector surface, satisfies this need.

  12. Altruism by age and social proximity.

    Science.gov (United States)

    Long, Mark C; Krause, Eleanor

    2017-01-01

    This study evaluates the extent to which an individual's stated altruistic sentiments can be influenced by context-most importantly, by the age and social proximity of the other person and by the nature of what is being sacrificed. We measure willingness to sacrifice own health for another person's health and willingness to sacrifice own wealth for another person's wealth. To evaluate these sentiments, two surveys were administered to representative samples of Americans which contained hypothetical scenarios with context randomly assigned; the first survey posed a dictator game question and the second survey was designed to elicit marginal rates of substitution between own and other's health/wealth. As expected, we find less altruism towards those who are more socially distant (e.g., strangers relative to family). We find individuals are more health altruistic towards young children and more wealth altruistic towards adults, and health altruism tends to be lowest for survey respondents near retirement age. We find no relationship between levels of altruism and the distance between the respondent's state of birth and state of current residence. These findings improve society's understanding of situational altruism and kinship and reciprocity as motivations for altruism, and they have practical implications concerning the economic valuation of human lives used to guide public policy-making.

  13. Proximal spinal muscular atrophy: current orthopedic perspective

    Directory of Open Access Journals (Sweden)

    Haaker G

    2013-11-01

    Full Text Available Gerrit Haaker, Albert Fujak Department of Orthopaedic Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany Abstract: Spinal muscular atrophy (SMA is a hereditary neuromuscular disease of lower motor neurons that is caused by a defective "survival motor neuron" (SMN protein that is mainly associated with proximal progressive muscle weakness and atrophy. Although SMA involves a wide range of disease severity and a high mortality and morbidity rate, recent advances in multidisciplinary supportive care have enhanced quality of life and life expectancy. Active research for possible treatment options has become possible since the disease-causing gene defect was identified in 1995. Nevertheless, a causal therapy is not available at present, and therapeutic management of SMA remains challenging; the prolonged survival is increasing, especially orthopedic, respiratory and nutritive problems. This review focuses on orthopedic management of the disease, with discussion of key aspects that include scoliosis, muscular contractures, hip joint disorders, fractures, technical devices, and a comparative approach of conservative and surgical treatment. Also emphasized are associated complications including respiratory involvement, perioperative care and anesthesia, nutrition problems, and rehabilitation. The SMA disease course can be greatly improved with adequate therapy with established orthopedic procedures in a multidisciplinary therapeutic approach. Keywords: spinal muscular atrophy, scoliosis, contractures, fractures, lung function, treatment, rehabilitation, surgery, ventilation, nutrition, perioperative management

  14. Optical proximity correction with principal component regression

    Science.gov (United States)

    Gao, Peiran; Gu, Allan; Zakhor, Avideh

    2008-03-01

    An important step in today's Integrated Circuit (IC) manufacturing is optical proximity correction (OPC). In model based OPC, masks are systematically modified to compensate for the non-ideal optical and process effects of optical lithography system. The polygons in the layout are fragmented, and simulations are performed to determine the image intensity pattern on the wafer. Then the mask is perturbed by moving the fragments to match the desired wafer pattern. This iterative process continues until the pattern on the wafer matches the desired one. Although OPC increases the fidelity of pattern transfer to the wafer, it is quite CPU intensive; OPC for modern IC designs can take days to complete on computer clusters with thousands of CPU. In this paper, techniques from statistical machine learning are used to predict the fragment movements. The goal is to reduce the number of iterations required in model based OPC by using a fast and efficient solution as the initial guess to model based OPC. To determine the best model, we train and evaluate several principal component regression models based on prediction error. Experimental results show that fragment movement predictions via regression model significantly decrease the number of iterations required in model based OPC.

  15. Altruism by age and social proximity.

    Directory of Open Access Journals (Sweden)

    Mark C Long

    Full Text Available This study evaluates the extent to which an individual's stated altruistic sentiments can be influenced by context-most importantly, by the age and social proximity of the other person and by the nature of what is being sacrificed. We measure willingness to sacrifice own health for another person's health and willingness to sacrifice own wealth for another person's wealth. To evaluate these sentiments, two surveys were administered to representative samples of Americans which contained hypothetical scenarios with context randomly assigned; the first survey posed a dictator game question and the second survey was designed to elicit marginal rates of substitution between own and other's health/wealth. As expected, we find less altruism towards those who are more socially distant (e.g., strangers relative to family. We find individuals are more health altruistic towards young children and more wealth altruistic towards adults, and health altruism tends to be lowest for survey respondents near retirement age. We find no relationship between levels of altruism and the distance between the respondent's state of birth and state of current residence. These findings improve society's understanding of situational altruism and kinship and reciprocity as motivations for altruism, and they have practical implications concerning the economic valuation of human lives used to guide public policy-making.

  16. Altruism by age and social proximity

    Science.gov (United States)

    2017-01-01

    This study evaluates the extent to which an individual’s stated altruistic sentiments can be influenced by context–most importantly, by the age and social proximity of the other person and by the nature of what is being sacrificed. We measure willingness to sacrifice own health for another person’s health and willingness to sacrifice own wealth for another person’s wealth. To evaluate these sentiments, two surveys were administered to representative samples of Americans which contained hypothetical scenarios with context randomly assigned; the first survey posed a dictator game question and the second survey was designed to elicit marginal rates of substitution between own and other’s health/wealth. As expected, we find less altruism towards those who are more socially distant (e.g., strangers relative to family). We find individuals are more health altruistic towards young children and more wealth altruistic towards adults, and health altruism tends to be lowest for survey respondents near retirement age. We find no relationship between levels of altruism and the distance between the respondent’s state of birth and state of current residence. These findings improve society’s understanding of situational altruism and kinship and reciprocity as motivations for altruism, and they have practical implications concerning the economic valuation of human lives used to guide public policy-making. PMID:28837557

  17. EVIDENCIAÇÃO DA GESTÃO DE RISCOS DO COSO (2004 NOS RELATÓRIOS DA ADMINISTRAÇÃO DE EMPRESAS BRASILEIRAS COM ADRs [doi: 10.5329/RECADM.20100902001

    Directory of Open Access Journals (Sweden)

    Vinícius Costa da Silva Zonatto

    2010-11-01

    Full Text Available Diego M. Coraiola 12.00 Normal 0 21 false false false PT-BR X-NONE X-NONE RESUMO O estudo objetiva analisar o conteúdo de evidenciação da gestão de riscos, tendo como referência a metodologia do Committee of Sponsoring Organizations of the Treadway Commission (COSO (2004, nos relatórios da administração das empresas brasileiras com emissão de American Depositary Receipt (ADRs na Bolsa de Valores de Nova York (NYSE. Estudo descritivo foi realizado por meio de pesquisa documental, utilizando-se da técnica da análise de conteúdo nos relatórios da administração de 28 empresas, tendo como unidade de registro o termo risco. Foram identificados 400 termos relacionados à gestão de riscos em ambientes de controle. O ambiente que apresenta maior evidenciação de termos relacionados à gestão de riscos é o ambiente de controle, e o menor, resposta ao risco. Conclui-se que não há uniformidade nas informações divulgadas pelas empresas a respeito das práticas de gestão de riscos. Em geral, divulgam ações relativas às atividades de controle e identificação de riscos, mas não indicam como respondem a estes riscos.   Palavras-Chave Evidenciação; gestão de riscos; coso; relatório da administração; empresas com adrs.     RISK MANAGEMENT OF COSO (2004 DISCLOSED ON THE ADMINISTRATION REPORTS OF BRAZILIAN COMPANIES ISSUING ADRs   ABSTRACT The goal of this study is analyze the content of the risk management disclosed, having as reference the methodology of Committee of Sponsoring Organizations of the Treadway Commission (COSO (2004, disclosed on the administration reports of Brazilian companies issuing American Depositary Receipts (ADRs in the New York Stock Exchange (NYSE.  A descriptive study was conducted through documental research, using the technique of content analysis on the administration reports of 28 companies, having as unit record the term risk. Were identified 400 terms related to risk management in control

  18. On the existence of best proximity points for generalized contractions

    Directory of Open Access Journals (Sweden)

    V. Vetrivel

    2014-04-01

    Full Text Available In this article we establish the existence of a unique best proximity point for some generalized non self contractions on a metric space in a simpler way using a geometric result. Our results generalize some recent best proximity point theorems and several fixed point theorems proved by various authors.

  19. Phytochemical, Proximate and Toxicity Studies of Aqueous Extract of ...

    African Journals Online (AJOL)

    Phytochemical, Proximate and Toxicity Studies of Aqueous Extract of Crinum ornatum (Toad's Onion) ... The results indicate that, the bulbs can be considered as a spice that could serve as potential sources of flavouring agent with medicinal benefits. Keywords: Crinum ornatum, Phytochemical, Proximate, Toxicity ...

  20. Proximity and inter-organizational collaboration: a literature review

    NARCIS (Netherlands)

    Knoben, J.; Oerlemans, L.A.G.

    2006-01-01

    The proximity concept is used in many different ways in the literature. These dimensions of proximity are, however, defined and measured in many different (sometimes even contradictory) ways, show large amounts of overlap, and often are under- or over-specified. The goal of this paper is to specify

  1. Proximate composition and levels of some toxicants in four ...

    African Journals Online (AJOL)

    Proximate composition and levels of some toxicants (anti-nutrients) in four commonly consumed spices were investigated. The spices were garlic (Allium sativum), ginger (Zingiber officinale), onion (Allium cepa var. cepa), and Piper guineense seeds (Ashanti pepper). Proximate analyses showed the spices to contain (on ...

  2. Proximal and distal muscle fatigue differentially affect movement coordination.

    Directory of Open Access Journals (Sweden)

    Jeffrey C Cowley

    Full Text Available Muscle fatigue can cause people to change their movement patterns and these changes could contribute to acute or overuse injuries. However, these effects depend on which muscles are fatigued. The purpose of this study was to determine the differential effects of proximal and distal upper extremity muscle fatigue on repetitive movements. Fourteen subjects completed a repetitive ratcheting task before and after a fatigue protocol on separate days. The fatigue protocol either fatigued the proximal (shoulder flexor or distal (finger flexor muscles. Pre/Post changes in trunk, shoulder, elbow, and wrist kinematics were compared to determine how proximal and distal fatigue affected multi-joint movement patterns and variability. Proximal fatigue caused a significant increase (7°, p < 0.005 in trunk lean and velocity, reduced humeral elevation (11°, p < 0.005, and increased elbow flexion (4°, p < 0.01. In contrast, distal fatigue caused small but significant changes in trunk angles (2°, p < 0.05, increased velocity of wrench movement relative to the hand (17°/s, p < 0.001, and earlier wrist extension (4%, p < 0.005. Movement variability increased at proximal joints but not distal joints after both fatigue protocols (p < 0.05. Varying movements at proximal joints may help people adapt to fatigue at either proximal or distal joints. The identified differences between proximal and distal muscle fatigue adaptations could facilitate risk assessment of occupational tasks.

  3. Properties of Sn-Ag proximity effect bridges

    Energy Technology Data Exchange (ETDEWEB)

    Fan Hongchang; Yu Zheng

    1983-09-01

    We have measured the I-V characteristics, I/sub c/(t) and T/sub c/ of Sn-Ag proximity effect bridges, obtaining some interesting results. We have also analyzed and tried to explain the results in terms of phenomenological theories, believing that microbridge theories of Skocpol, Beasley and Tinkham (SBT) also apply to our proximity effect bridges.

  4. Determination of Proximate Composition and Amino Acid Profile of ...

    African Journals Online (AJOL)

    The proximate composition and amino acid profile of the seed of 30 Nigerian sesame genotypes were determined based on the standard methods of the Association of Official Analytical Chemists (AOAC) and the Sequential Multi- sample amino acid Analyzer (TSM). Proximate analysis showed that sesame seed contained ...

  5. Management of proximal interphalangeal joint dislocations in athletes.

    Science.gov (United States)

    Bindra, Randy R; Foster, Brian J

    2009-08-01

    Proximal interphalangeal joint dislocations are common athletic injuries. In dislocations and fracture dislocations, the most important treatment principle is congruent joint reduction and maintenance of stability. This article reviews the relevant anatomy, injury characteristics, and treatment options for proximal interphalangeal joint dislocations and fracture dislocations. Treatment methods discussed include closed reduction, percutaneous fixation, and open reduction.

  6. Water Balance and Proximate Composition in Cowpea ( vigna ...

    African Journals Online (AJOL)

    Studying the water balance and proximate composition in plants subjected to these stresses compared the influence of drought and flooding on cowpea seedlings. In drought plants the leaf water potential, its components and the proximate composition were markedly reduced by the end of the experimental period.

  7. Cast index in predicting outcome of proximal pediatric forearm fractures

    Directory of Open Access Journals (Sweden)

    Hassaan Qaiser Sheikh

    2015-01-01

    Conclusion: Cast index is useful in predicting redisplacement of manipulated distal forearm fractures. We found that in proximal half forearm fractures it is difficult to achieve a CI of <0.8, but increased CI does not predict loss of position in these fractures. We therefore discourage the use of CI in proximal half forearm fractures.

  8. Proximate composition and mineral contents of Pebbly fish, Alestes ...

    African Journals Online (AJOL)

    ACSS

    The objective of this study was to determine the proximate composition and mineral contents of A. ... and also develop suitable processing method. This study determined the proximate composition and mineral contents of A. baremoze fillets based on fish size. Materials and .... moisture contents can vary with sex of the fish ...

  9. proximal femur geometry in the adult kenyan femur and its ...

    African Journals Online (AJOL)

    implications considering that the implants used to treat fractures in the proximal femur would usually traverse the neck and lodge in the femoral head. A very narrow neck may not allow adequate implant placement especially for those implants that employ two proximal locking screws. This has been shown, in a study by ...

  10. Spontaneous Healing of a Pediatric Scaphoid Proximal Pole Fracture Nonunion.

    Science.gov (United States)

    Rupani, Neal; Riley, Nicholas; McNab, Ian

    2018-02-01

    Background  Scaphoid fractures in the pediatric population are rare. The majority of nondisplaced fractures tend to unite; however, there is an increased risk of nonunion in proximal pole fractures. Limited evidence exists in their outcomes, owing to the scarcity of the fracture pattern. Case Description  A 13-year-old boy who presented late after developing a traumatic proximal pole scaphoid fracture developed nonunion. He was treated conservatively owing to it being asymptomatic and developed union at 18 months. Literature Review  No previous case of proximal pole pediatric scaphoid fractures with established nonunion that has developed union with conservative management has been described. Clinical Relevance  The authors highlight a unique case of an established proximal pole scaphoid nonunion in a child progressing to union with nonoperative intervention. Owing to its rarity and difficulty in obtaining research, we recommend consideration of nonoperative management of asymptomatic nondisplaced proximal pole fractures in children.

  11. Nanocrystal Bioassembly: Asymmetry, Proximity, and Enzymatic Manipulation

    Energy Technology Data Exchange (ETDEWEB)

    Claridge, Shelley A. [Univ. of California, Berkeley, CA (United States)

    2008-05-01

    Research at the interface between biomolecules and inorganic nanocrystals has resulted in a great number of new discoveries. In part this arises from the synergistic duality of the system: biomolecules may act as self-assembly agents for organizing inorganic nanocrystals into functional materials; alternatively, nanocrystals may act as microscopic or spectroscopic labels for elucidating the behavior of complex biomolecular systems. However, success in either of these functions relies heavily uponthe ability to control the conjugation and assembly processes.In the work presented here, we first design a branched DNA scaffold which allows hybridization of DNA-nanocrystal monoconjugates to form discrete assemblies. Importantly, the asymmetry of the branched scaffold allows the formation of asymmetric2assemblies of nanocrystals. In the context of a self-assembled device, this can be considered a step toward the ability to engineer functionally distinct inputs and outputs.Next we develop an anion-exchange high performance liquid chromatography purification method which allows large gold nanocrystals attached to single strands of very short DNA to be purified. When two such complementary conjugates are hybridized, the large nanocrystals are brought into close proximity, allowing their plasmon resonances to couple. Such plasmon-coupled constructs are of interest both as optical interconnects for nanoscale devices and as `plasmon ruler? biomolecular probes.We then present an enzymatic ligation strategy for creating multi-nanoparticle building blocks for self-assembly. In constructing a nanoscale device, such a strategy would allow pre-assembly and purification of components; these constructs can also act as multi-label probes of single-stranded DNA conformational dynamics. Finally we demonstrate a simple proof-of-concept of a nanoparticle analog of the polymerase chain reaction.

  12. Translational Imaging Spectroscopy for Proximal Sensing.

    Science.gov (United States)

    Rogass, Christian; Koerting, Friederike M; Mielke, Christian; Brell, Maximilian; Boesche, Nina K; Bade, Maria; Hohmann, Christian

    2017-08-11

    Proximal sensing as the near field counterpart of remote sensing offers a broad variety of applications. Imaging spectroscopy in general and translational laboratory imaging spectroscopy in particular can be utilized for a variety of different research topics. Geoscientific applications require a precise pre-processing of hyperspectral data cubes to retrieve at-surface reflectance in order to conduct spectral feature-based comparison of unknown sample spectra to known library spectra. A new pre-processing chain called GeoMAP-Trans for at-surface reflectance retrieval is proposed here as an analogue to other algorithms published by the team of authors. It consists of a radiometric, a geometric and a spectral module. Each module consists of several processing steps that are described in detail. The processing chain was adapted to the broadly used HySPEX VNIR/SWIR imaging spectrometer system and tested using geological mineral samples. The performance was subjectively and objectively evaluated using standard artificial image quality metrics and comparative measurements of mineral and Lambertian diffuser standards with standard field and laboratory spectrometers. The proposed algorithm provides highly qualitative results, offers broad applicability through its generic design and might be the first one of its kind to be published. A high radiometric accuracy is achieved by the incorporation of the Reduction of Miscalibration Effects (ROME) framework. The geometric accuracy is higher than 1 μpixel. The critical spectral accuracy was relatively estimated by comparing spectra of standard field spectrometers to those from HySPEX for a Lambertian diffuser. The achieved spectral accuracy is better than 0.02% for the full spectrum and better than 98% for the absorption features. It was empirically shown that point and imaging spectrometers provide different results for non-Lambertian samples due to their different sensing principles, adjacency scattering impacts on the signal

  13. Observer differentiation of proximal enamel mechanical defects versus natural proximal dental caries with computed dental radiography.

    Science.gov (United States)

    Kang, B C; Farman, A G; Scarfe, W C; Goldsmith, L J

    1996-10-01

    Various models have been used to study the accuracy of imaging systems for detection of dental caries. This study compares the ability of dentists to detect mechanically created defects versus natural dental caries cavitations on the proximal surfaces of extracted teeth with Computed Dental Radiography (Schick Industries, Long Island City, N.Y.). Detection rates are investigated according to lesion depth to permit comparisons to be made between studies in the literature with other mechanical defects or natural caries models. Discrimination of natural caries versus artificial defects with Computed Dental Radiography is also compared with a previous report that used standard dental film. Fifty-two extracted molar and premolar teeth were mounted into representative sets of maxillary and mandibular posterior arches for bite-wing radiography. There were 16 proximal surfaces with natural caries and 28 proximal surfaces with mechanical defects. An optical bench was used to ensure constant beam geometry. A 1.8 cm acrylic soft tissue equivalent attenuator was placed in front of the receptor. Thirty dentists acted independently as observers to differentiate between sound proximal tooth surfaces, natural dental caries, and mechanical defects. Evaluation of intra- and interobserver variability was made with use of the kappa statistic. The Zelen test of odds ratios was used to test for homogeneity, and the Mantel-Haenszel analysis plus stratified logistic regression were used for inference about the common odds ratio. Significance was set at p detection was 74% for mechanical defects and 67% for natural caries. The odds of detecting a mechanical defect were 1.40 times the odds of finding natural dental caries cavitation of the same depth. Lesion depth did influence the probability of correctly identifying the presence of a lesion; the odds of identifying cavitation increased 1.41 times with every 0.1 mm increase in lesion depth. Correct designation of lesion type was 1.42 times

  14. Numerical Optimization of the Position in Femoral Head of Proximal Locking Screws of Proximal Femoral Nail System; Biomechanical Study.

    Science.gov (United States)

    Konya, Mehmet Nuri; Verim, Özgür

    2017-09-29

    Proximal femoral fracture rates are increasing due to osteoporosis and traffic accidents. Proximal femoral nails are routinely used in the treatment of these fractures in the proximal femur. To compare various combinations and to determine the ideal proximal lag screw position in pertrochanteric fractures (Arbeitsgemeinschaft für Osteosynthesefragen classification 31-A1) of the femur by using optimized finite element analysis. Biomechanical study. Computed tomography images of patients' right femurs were processed with Mimics. Afterwards a solid femur model was created with SolidWorks 2015 and transferred to ANSYS Workbench 16.0 for response surface optimization analysis which was carried out according to anterior-posterior (-10°0) and posterior-anterior directions of the femur neck significantly increased these stresses. The most suitable position of the proximal lag screw was confirmed as the middle of the femoral neck by using optimized finite element analysis.

  15. Instrument access device for instrument access system, has connector member connecting proximal member with instrument seals, where proximal member and connector member are configured to retain proximal end of retractor member

    OpenAIRE

    Bonadio, Frank; Vaugh, Trevor; McManus, Ronan; MacNally, Shane

    2010-01-01

    The device (203) has instrument seals sealingly arranged in a body of a patient, and a distal anchoring member located in a wound interior. A retractor member is proximally extended from a distal anchoring member to retract sides of a wound opening. A proximal member is adopted for locating an external part of the wound opening. A connector member connects the proximal member with the instrument seals. The proximal member and the connector member are configured to retain a proximal end of the...

  16. Effect of age on proximal esophageal response to swallowing

    Directory of Open Access Journals (Sweden)

    Roberto Oliveira Dantas

    2010-12-01

    Full Text Available CONTEXT: It has been demonstrated that the ageing process affects esophageal motility. OBJECTIVES: To evaluate the effect of the age on the proximal esophageal response to wet swallows. METHOD: We measured the proximal esophageal response to swallows of a 5 mL bolus of water in 69 healthy volunteers, 20 of them aged 18-30 years (group I, 27 aged 31-50 years (group II, and 22 aged 51-74 years (group III. We used the manometric method with continuous perfusion. The proximal esophageal contractions were recorded 5 cm from a pharyngeal recording site located 1 cm above the upper esophageal sphincter. The time between the onset of the pharyngeal and of the proximal esophageal recording (pharyngeal-esophageal time and the amplitude, duration and area under the curve of the proximal esophageal contraction were measured. RESULTS: The pharyngeal-esophageal time was shorter in group I subjects than in group II and III subjects (P<0.05. The duration of proximal esophageal contractions was longer in group I than in groups II and III (P<0.001. There was no differences between groups in the amplitude or area under the curve of contractions. There were no differences between groups II and III for any of the measurements. CONCLUSION: We conclude that the age may affects the response of the proximal esophagus to wet swallows.

  17. Dual pathology proximal median nerve compression of the forearm.

    LENUS (Irish Health Repository)

    Murphy, Siun M

    2013-12-01

    We report an unusual case of synchronous pathology in the forearm- the coexistence of a large lipoma of the median nerve together with an osteochondroma of the proximal ulna, giving rise to a dual proximal median nerve compression. Proximal median nerve compression neuropathies in the forearm are uncommon compared to the prevalence of distal compression neuropathies (eg Carpal Tunnel Syndrome). Both neural fibrolipomas (Refs. 1,2) and osteochondromas of the proximal ulna (Ref. 3) in isolation are rare but well documented. Unlike that of a distal compression, a proximal compression of the median nerve will often have a definite cause. Neural fibrolipoma, also called fibrolipomatous hamartoma are rare, slow-growing, benign tumours of peripheral nerves, most often occurring in the median nerve of younger patients. To our knowledge, this is the first report of such dual pathology in the same forearm, giving rise to a severe proximal compression of the median nerve. In this case, the nerve was being pushed anteriorly by the osteochondroma, and was being compressed from within by the intraneural lipoma. This unusual case highlights the advantage of preoperative imaging as part of the workup of proximal median nerve compression.

  18. Digital contrast subtraction radiography for proximal caries diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Byung Cheol; Yoon, Suk Ja [Department of Dental Radiology, Chonnam National University Hospital, Gwangju (Korea, Republic of)

    2002-06-15

    To determine whether subtraction images utilizing contrast media can improve the diagnostic performance of proximal caries diagnosis compared to conventional periapical radiographic images. Thirty-six teeth with 57 proximal surfaces were radiographied using a size no.2 RVG-ui sensor (Trophy Radiology, Marne-la-Vallee, France). The teeth immersed in water-soluble contrast media and subtraction images were taken. Each tooth was then sectioned for histologic examination. The digital radiographic images and subtraction images were examined and interpreted by three dentists for proximal caries. The results of the proximal caries diagnosis were then verified with the results of the histologic examination. The proximal caries sensitivity using digital subtraction radiography was significantly higher than simply examining a single digital radiograph. The sensitivity of the proximal dentinal carious lesion when analyzed with the subtraction radiograph and the radiograph together was higher than with the subtraction radiograph or the radiograph alone. The use of subtraction radiography with contrast media may be useful for detecting proximal dentinal carious lesions.

  19. Proximity to urban parks and mental health.

    Science.gov (United States)

    Sturm, Roland; Cohen, Deborah

    2014-03-01

    Urban parks have received attention in recent years as a possible environmental factor that could encourage physical activity, prevent obesity, and reduce the incidence of chronic conditions. Despite long hypothesized benefits of parks for mental health, few park studies incorporate mental health measures. To test the association between proximity to urban parks and psychological distress. Cross-sectional analysis of individual health survey responses. Data were collected for a study of capital improvements of neighborhood parks in Los Angeles. A survey was fielded on a sample of residential addresses, stratified by distance from the park (within 400m, 800m, 1.6 km, and 3.2km; N=1070). We used multiple regression to estimate the relationship between the psychological distress as measured by the MHI-5 (outcome variable) and distance to parks (main explanatory variable), controlling for observed individual characteristics. Mental health is significantly related to residential distance from parks, with the highest MHI-5 scores among residents within short walking distance from the park (400m) and decreasing significantly over the next distances. The number of visits and physical activity minutes are significantly and independently related to distance, although controlling for them does not reduce the association between distance and mental health. This paper provides a new data point for an arguably very old question, but for which empirical data are sparse for the US. A nearby urban park is associated with the same mental health benefits as decreasing local unemployment rates by 2 percentage points, suggesting at least the potential of environmental interventions to improve mental health. The analysis is cross-sectional, making it impossible to control for important confounders, including residential selection. Mental health policy has traditionally focused on individual-centered interventions. Just as health policy for preventable chronic illnesses has shifted

  20. Proximal caries detection: Sirona Sidexis versus Kodak Ektaspeed Plus.

    Science.gov (United States)

    Khan, Emad A; Tyndall, Donald A; Ludlow, John B; Caplan, Daniel

    2005-01-01

    This study compared the accuracy of intraoral film and a charge-coupled device (CCD) receptor for proximal caries detection. Four observers evaluated images of the proximal surfaces of 40 extracted posterior teeth. The presence or absence of caries was scored using a five-point confidence scale. The actual status of each surface was determined from ground section histology. Responses were evaluated by means of receiver operating characteristic (ROC) analysis. Areas under ROC curves (Az) were assessed through a paired t-test. The performance of the CCD-based intraoral sensor was not different statistically from Ektaspeed Plus film in detecting proximal caries.

  1. Ajustes aos US-GAAPS: estudo empírico sobre sua relevância para empresas brasileiras com ADRs negociados na bolsa de Nova Iorque Adjustments to US-GAAPS: empirical study on their relevance for brazilian companies with ADR traded on the New York exchange

    Directory of Open Access Journals (Sweden)

    Fábio Moraes da Costa

    2007-06-01

    Full Text Available A relevância das informações disponibilizadas ao mercado por empresas brasileiras com American Depositary Recepts (ADRs negociados na Bolsa de Nova Iorque foi avaliada neste trabalho. Essas empresas devem atender à exigência da Securities and Exchange Commission e elaborar suas demonstrações contábeis de acordo com os United States Generally Accepted Accounting Principles (US-GAAP até 30 de junho, anualmente. Diante desse fato, dois conjuntos de informações estão disponíveis, promovendo a base de dados para o estudo da relevância das variáveis lucro líquido e patrimônio líquido para o período entre 1999 e 2003. Após a utilização do modelo desenvolvido por Ohlson (1995 e de seus desdobramentos posteriores, os resultados evidenciam que (1 as informações elaboradas segundo os princípios de contabilidade geralmente aceitos no Brasil são relevantes; (2 as informações em US-GAAP disponibilizadas em junho possuem menor ou igual relevância do que as divulgadas em abril e (3 os ajustes aos US-GAAP efetuados no patrimônio líquido são relevantes para o mercado de capitais brasileiro.This study evaluated the value-relevance of the information disclosed by Brazilian companies with American Depositary Receipts traded on the New York Stock Exchange. Those companies must comply with the requirement of the Securities and Exchange Commission and elaborate their financial statements according to the United States Generally Accepted Accounting Principles (US-GAAP until 30th of June, annually. Thus, two sets of information are available, providing data to evaluate the value-relevance of the variables net income and stockholders’ equity, from 1999 to 2003. After applying the model Ohlson developed in 1995 and its further developments, results indicate that (1 the information elaborated according to the generally accepted accounting principles in Brazil are value-relevant; (2 the relevance of the information in US-GAAP made available

  2. On Optimal Fuzzy Best Proximity Coincidence Points of Proximal Contractions Involving Cyclic Mappings in Non-Archimedean Fuzzy Metric Spaces

    Directory of Open Access Journals (Sweden)

    Manuel De la Sen

    2017-04-01

    Full Text Available The main objective of this paper is to deal with some properties of interest in two types of fuzzy ordered proximal contractions of cyclic self-mappings T integrated in a pair ( g , T of mappings. In particular, g is a non-contractive fuzzy self-mapping, in the framework of non-Archimedean ordered fuzzy complete metric spaces and T is a p -cyclic proximal contraction. Two types of such contractions (so called of type I and of type II are dealt with. In particular, the existence, uniqueness and limit properties for sequences to optimal fuzzy best proximity coincidence points are investigated for such pairs of mappings.

  3. Population Exposure Estimates in Proximity to Nuclear Power Plants, Locations

    Data.gov (United States)

    National Aeronautics and Space Administration — The Population Exposure Estimates in Proximity to Nuclear Power Plants, Locations data set combines information from a global data set developed by Declan Butler of...

  4. Transverse Stress Fracture of the Proximal Patella: A Case Report

    National Research Council Canada - National Science Library

    Atsumi, Satoru; Arai, Yuji; Kato, Ko; Nishimura, Akinobu; Nakazora, Shigeto; Nakagawa, Shuji; Ikoma, Kazuya; Fujiwara, Hiroyoshi; Sudo, Akihiro; Kubo, Toshikazu

    2016-01-01

    .... Regarding patella stress fractures, so far only distal transverse or lateral longitudinal fractures have been reported, but there are no reports of transverse fractures occurring in the proximal patella...

  5. Genetics Home Reference: proximal 18q deletion syndrome

    Science.gov (United States)

    ... can range from mild to severe. In particular, vocabulary and the production of speech (expressive language skills) ... Some affected individuals have an unusually large head size ( macrocephaly ). People with proximal 18q deletion syndrome often ...

  6. Perinatal mortality and residential proximity to an industrial park.

    Science.gov (United States)

    Sarov, Batia; Bentov, Yaakov; Kordysh, Ella; Karakis, Isabella; Bolotin, Arkady; Hershkovitz, Reli; Belmaker, Ilana

    2008-01-01

    The authors' objective was to determine whether residential proximity to an industrial park (IP) is associated with increased perinatal mortality (PM). This semiecological study included 63,850 delivered births with 840 cases of PM (1995-2000). The authors categorized the study populations by ethnicity (ie, Bedouin and Jewish) and type of locality. Residential distance from the IP served as a surrogate indicator of exposure. Among Bedouin newborns, proximity to the IP was associated with increased PM rates (relative risk = 1.45; 95% confidence interval = 1.22-1.72). The excess in PM was not related to maternal or newborn physical characteristics that the authors observed. The risk of PM and its components in the Jewish localities was not associated with IP proximity. The association between residential proximity to the IP and excess in PM among only Bedouin newborns may be related to vulnerability caused by the nomadic nature of the society.

  7. Computational proximity excursions in the topology of digital images

    CERN Document Server

    Peters, James F

    2016-01-01

    This book introduces computational proximity (CP) as an algorithmic approach to finding nonempty sets of points that are either close to each other or far apart. Typically in computational proximity, the book starts with some form of proximity space (topological space equipped with a proximity relation) that has an inherent geometry. In CP, two types of near sets are considered, namely, spatially near sets and descriptivelynear sets. It is shown that connectedness, boundedness, mesh nerves, convexity, shapes and shape theory are principal topics in the study of nearness and separation of physical aswell as abstract sets. CP has a hefty visual content. Applications of CP in computer vision, multimedia, brain activity, biology, social networks, and cosmology are included. The book has been derived from the lectures of the author in a graduate course on the topology of digital images taught over the past several years. Many of the students have provided important insights and valuable suggestions. The topics in ...

  8. Proximate and Amino Acid Composition of Celosia argentea Leaves ...

    African Journals Online (AJOL)

    % respectively while ... were analyzed using flame photometer for K and ... low in methionine. Table 1: Proximate Composition of C. argentea. Parameter. Composition (%). Moisture content. Crude Fat. Crude protein. Crude fibre. Ash. Nitrogen ...

  9. [A case of proximal type epithelioid sarcoma of the perineum].

    Science.gov (United States)

    Murashima, Takaya; Kamibeppu, Toyoharu; Hiromasa, Tukino; Mukai, Syoichiro; Kamoto, Toshiyuki

    2013-11-01

    Epithelioid sarcomas are rare soft tissue neoplasms which occur more often in young people. They tend to relapse, metastatize and show poor prognosis. Proximal-type epithelioid sarcomas arise from the more proximal part of body and are more malignant than distal-type epithelioid sarcomas. We present a case of proximal-type epithelioid sarcoma which occurred in the perineum. A 24-year-old male visited our hospital with the chief complaint of pain in the perineum. Computed tomography and magnetic resonance imaging showed a tumor 30×23×17 mm in diameter in the perineal region. The tumor was excised regionally and the pathological examination with immunohistochemical staining revealed that the tumor was proximal-type epithelioid sarcoma. The patient is free of recurrence and metastasis one year after local excision.

  10. Effect of processing method on the Proximate composition, mineral ...

    African Journals Online (AJOL)

    Effect of processing method on the Proximate composition, mineral content and antinutritional factors of Taro (Colocasia esculenta, L.) growth in Ethiopia. T Adane, A Shimelis, R Negussie, B Tilahun, GD Haki ...

  11. TETRAPOLIS - an exercise in building the complexities of proximity space

    National Research Council Canada - National Science Library

    Cristian Blidariu; Diana Giurea

    2017-01-01

    ... student’s intuitive ways for understanding these vicinities, their physical and symbolic proximities, through participatory tactics and certain poetic/architectural tools required in the phenomenological build-up of space...

  12. The KCNH2 genetic polymorphism (1956, C>T is a novel biomarker that is associated with CCB and α,β-ADR blocker response in EH patients in China.

    Directory of Open Access Journals (Sweden)

    Fazhong He

    Full Text Available KCNH2 (hERG potassium channels have an integral role in regulating the excitability of smooth muscle cells. Some pathways driven by angiotensin II, nitric oxide and adrenergic receptors blocker are involved in modulating the properties of KCNH2 potassium channels. And these pathways are closely related to blood pressure regulation. Therefore, we hypothesized that KCNH2 genetic polymorphisms may affect blood pressure response to the antihypertensive drug therapies.To evaluate the interactions between KCNH2 genetic polymorphisms and individual blood pressure response to antihypertensive drugs, 370 subjects with essential hypertension (EH were studied. In evaluating the interactions between KCNH2 genetic polymorphisms and drug response to blood pressure, multivariable ANOVA analysis followed by Bonferroni correction were carried out.There were statistically significant interactions between KCNH2 (1956, C>T polymorphism and DBP change (P = 0.010, MAP change (P = 0.014 on azelnidipine or nitrendipine therapy patients at the end of 6 weeks. We found that the KCNH2 (1956,C>T polymorphism was associated with the hypotensive effects of α,β-ADR blockers of DBP change at the end of 4 and 6 weeks' treatment in an age- and gender-dependent manner (P = 0.007 and 0.019, respectively. Similar results were also observed for changes in MAP at the end of 4 and 6 weeks (P-values were 0.035 and 0.078, respectively. While patients who received imidapril, candesartan and irbesartan therapy, no significant difference in drug response among KCNH2(1956,C>T genotype was observed.We have reported for the first time that KCNH2 (1956, C>T polymorphism is associated with efficacy of antihypertensive drugs CCBs and ADR blockers, and may serve as a novel biomarker for individualized therapy for certain antihypertensive drugs.

  13. Orthopaedic approaches to proximal humeral fractures following trauma.

    OpenAIRE

    Mafi, R.; Khan, W.; Mafi, P; Hindocha, S.

    2014-01-01

    Proximal humeral fractures have been a topic of discussion in medical literature dating back as far as 3rd century BC. Today, these fractures are the most common type of humeral fractures and account for about 5-6% of all fractures in adults with the incidence rising rapidly with age. In broad terms the management of proximal humeral fractures can be divided into two categories: conservative versus surgical intervention. The aim of treatment is to stabilize the fracture, aid better union and ...

  14. Conservative Treatment for Bilateral Displaced Proximal Humerus Head Fracture

    OpenAIRE

    Rodriguez-Corlay, Ruy E; Velutini-Becker, Ricardo; Aguilar-Alcal?, Luis D

    2016-01-01

    Proximal humerus fracture represents five to eight percent of all fractures and is twice as common in women than in men. Most cases of displaced fracture of the proximal humerus are treated surgically; it is probable that more cases are preferred to be treated surgically greater than required. The optimal treatment for these fractures remains controversial, but physicians have a tendency to treat via open reduction and fixation with angular locking plates or glenohumeral arthroplasty.? We pre...

  15. Proximal and distal muscle fatigue differentially affect movement coordination

    OpenAIRE

    Cowley, Jeffrey C.; Gates, Deanna H.

    2017-01-01

    Muscle fatigue can cause people to change their movement patterns and these changes could contribute to acute or overuse injuries. However, these effects depend on which muscles are fatigued. The purpose of this study was to determine the differential effects of proximal and distal upper extremity muscle fatigue on repetitive movements. Fourteen subjects completed a repetitive ratcheting task before and after a fatigue protocol on separate days. The fatigue protocol either fatigued the proxim...

  16. Developing survey metrics for analysing cross-border proximity

    DEFF Research Database (Denmark)

    Makkonen, Teemu; Williams, Allan

    2017-01-01

    Cross-border innovation cooperation (CBIC) has been heralded as one of the corner stones of innovation-driven growth opportunities for firms located in cross-border regions (CBRs). The success of this cooperation is affected by varying types of proximities identified in the literature....... The findings indicate that the developed survey metrics are effective in depicting the phenomenon of proximity. The foundational work undertaken in this research note provides a platform, and catalyst, for more extensive investigations of the topic....

  17. Partial proximal trisomy 10q syndrome: a new case.

    Science.gov (United States)

    Nucaro, A; Faedda, A; Cao, A; Boccone, L

    2002-01-01

    We report a case of partial proximal trisomy of the long arm of chromosome 10 confirmed by fluorescence in situ hibridization (FISH) performed with whole chromosome 10 specific painting and specific yac clones. The phenotypic findings, compared to those found in other published cases with the same karyotype, support the recognition of a distinctive partial proximal trisomy 10q syndrome (10q11-->q22).

  18. Proximity functions for electrons up to 10 keV

    Energy Technology Data Exchange (ETDEWEB)

    Chmelevsky, D. (Institut fuer Medizinische Strahlenkunde der Universitaet Wuerzburg, Germany); Kellerer, A.M.; Terrissol, M.; Patau, J.P.

    1980-11-01

    Proximity functions for electrons up to 10 keV in water are computed from simulated particle tracks. Numerical results are given for the differential functions t(x) and the integral functions T(x). Basic characteristics of these functions and their connections to other microdosimetric quantities are considered. As an example of the applicability of the proximity functions, the quantity y/sub D/ for spheres is derived from t(x).

  19. Inexact proximal Newton methods for self-concordant functions

    DEFF Research Database (Denmark)

    Li, Jinchao; Andersen, Martin Skovgaard; Vandenberghe, Lieven

    2016-01-01

    We analyze the proximal Newton method for minimizing a sum of a self-concordant function and a convex function with an inexpensive proximal operator. We present new results on the global and local convergence of the method when inexact search directions are used. The method is illustrated...... matrices with chordal sparsity patterns are used to evaluate gradients and matrix-vector products with the Hessian of the smooth component of the objective....

  20. Critical Proximity as a Methodological Move in Techno-Anthropology

    OpenAIRE

    Birkbak, Andreas; Petersen, Morten Krogh; Elgaard Jensen, Torben

    2015-01-01

    echno-Anthropology is a new field, operating with a broad range of methodologies and approaches. This gives rise to the question: What does it mean for Techno-Anthropological research to be critical? In this paper, we discuss this question by developing and specifying the notion of ‘critical proximity.’ Critical proximity offers an alternative to critical distance, especially with respect to avoiding premature references to abstract panoramas such as democratization and capitalist exploitatio...

  1. Design and Clinical Application of Proximal Humerus Memory Connector

    Science.gov (United States)

    Xu, Shuo-Gui; Zhang, Chun-Cai

    2011-02-01

    Treatment for comminuted proximal humerus fractures and nonunions are a substantial challenge for orthopedic surgeons. Plate and screw fixation does not provide enough stability to allow patients to begin functional exercises early after surgery. Using shape memory material nickel titanium alloy, we designed a new device for treating severe comminuted proximal humerus fractures that accommodates for the anatomical features of the proximal humerus. Twenty-two cases of comminuted fracture, malunion, and nonunion of the proximal humerus were treated with the proximal humeral memory connector (PHMC). No external fixation was needed after the operation and patients began active shoulder exercises an average of 8 days after the operation. Follow-up evaluation (mean 18.5 months) revealed that bone healing with lamellar bone formation occurred an average of 3.6 months after surgery for the fracture cases and 4.5 months after surgery for the nonunion cases. Average shoulder function was 88.5 according to the criteria of Michael Reese. PHMC is an effective new device to treat comminuted proximal humerus fractures and nonunions. The use of this device may reduce the need for shoulder joint arthroplasty.

  2. The sooner, the better: exercise outcome proximity and intrinsic motivation.

    Science.gov (United States)

    Evans, M Blair; Cooke, Lisa M; Murray, Robyn A; Wilson, Anne E

    2014-11-01

    Despite evidence that outcomes are highly valued when they are expected sooner rather than further into the future (Ainslie, 1975), limited research effort has been devoted to understanding the role of exercise outcome proximity. The purpose of this study was to examine how temporal proximity to positive outcomes influences exercisers' intrinsic motivation. We expected that focusing people on temporally proximal exercise outcomes would increase intrinsic motivation, especially among low-frequency exercisers. This online experimental study was completed by 135 community exercisers (Mage  = 31.11, SD = 10.29; 62% female) who reported an average of 4.86 exercise bouts per week (SD = 2.12). Participants were randomly assigned to a condition that primed temporally proximal positive exercise outcomes (i.e. experienced during or directly following an exercise bout) or temporally distal outcomes (i.e. experienced after days, months, or years of regular exercise). Participants then reported perceptions of behavioral regulation in exercise. As expected, the proximal exercise outcome condition elicited increased intrinsic regulation among those participants who exercised less frequently (i.e. 1 SD below the mean). This study reveals the importance of considering proximity as an important dimension of exercise outcomes-particularly when promoting intrinsic motivation among relatively infrequent exercisers. © 2014 The International Association of Applied Psychology.

  3. Optical proximity correction: a first look at manufacturability

    Science.gov (United States)

    Liebmann, Lars W.; Grenon, Brian J.; Lavin, Mark A.; Schomody, Stephen; Zell, Thomas

    1994-12-01

    The feasibility of large scale optical proximity correction with a focus on mask manufacturability is demonstrated on the support and logic gates of a leading edge 64 Mb DRAM chip. Analysis of post reactive ion etch SEM data of the 500 - 600 nm, DUV exposed gates indicates two major contributors to across chip line width variation: first order proximity, that is, the minimum spacing to the nearest neighboring structure, and local area density or pattern loading. Data presented show a very long range (approximately equals 1 mm) impact of pattern density on post reactive ion etch line widths, favoring optical proximity correction approaches that are not based on biasing patterns to compensate for these effects. In this project, pattern density induced effects were alleviated by homogenizing the pattern loading across the chip to approximately 50% instead of biasing the gate structures to compensate for pattern density differences. Proximity induced effects were compensated for with a one- dimensional, single parameter (distance to nearest neighbor), four bucket proximity correction routine with a strong focus on mask manufacturability. Even though the unbiased 64 Mb DRAM gate level challenges mask makers with 480 MB of MEBES data, the optical proximity corrected mask posed no substantial post-processing, writing, or inspection problems in IBM's Burlington, Vermont maskhouse. A very significant 80% reduction in post reactive ion etch across chip line width variation was achieved with this corrected mask.

  4. Lactate oxidation by three segments of the rabbit proximal tubule

    Energy Technology Data Exchange (ETDEWEB)

    Brand, P.H.; Taylor, B.B.

    1986-09-01

    Oxidation of (U/sup 14/C)lactate to /sup 14/CO/sub 2/ was measured in vitro, in nonperfused anatomically defined segments of rabbit proximal tubule (S1, proximal convoluted, and S2 and S3, proximal straight tubules). The rate of lactate oxidation was similar in S2 and S3 segments, and within the range of lactate oxidation rates measured in vivo. In contrast, the oxidation rate of S1 segments was significantly lower than that of S2 or S3. In proximal straight tubules, lactate oxidation was inhibited by incubation at 0/sup 0/C, or by application of 1 mM ouabain. To determine if the rate of transepithelial transport affected the rate of lactate oxidation, lactate oxidation was measured in proximal straight tubules after the lumen had been opened by perfusion with Ringer's containing 10 mM polyethylene glycol. No difference in lactate oxidation rate was observed between tubules with patent lumina and nonperfused tubules. These results suggest that the various segments of the renal proximal tubule have difference metabolic characteristics, and that the rate of substrate oxidation is related to the activity of the Na/sup +/, K/sup +/-ATPase.

  5. Psychological responses to the proximity of climate change

    Science.gov (United States)

    Brügger, Adrian; Dessai, Suraje; Devine-Wright, Patrick; Morton, Thomas A.; Pidgeon, Nicholas F.

    2015-12-01

    A frequent suggestion to increase individuals' willingness to take action on climate change and to support relevant policies is to highlight its proximal consequences, that is, those that are close in space and time. But previous studies that have tested this proximizing approach have not revealed the expected positive effects on individual action and support for addressing climate change. We present three lines of psychological reasoning that provide compelling arguments as to why highlighting proximal impacts of climate change might not be as effective a way to increase individual mitigation and adaptation efforts as is often assumed. Our contextualization of the proximizing approach within established psychological research suggests that, depending on the particular theoretical perspective one takes on this issue, and on specific individual characteristics suggested by these perspectives, proximizing can bring about the intended positive effects, can have no (visible) effect or can even backfire. Thus, the effects of proximizing are much more complex than is commonly assumed. Revealing this complexity contributes to a refined theoretical understanding of the role that psychological distance plays in the context of climate change and opens up further avenues for future research and for interventions.

  6. The validity of proximal caries detection using magnifying visual aids.

    Science.gov (United States)

    Haak, Rainer; Wicht, Michael J; Hellmich, Martin; Gossmann, Andrea; Noack, Michael J

    2002-01-01

    The purpose of this study was to determine the validity of proximal caries detection supported by a prism loupe and a surgical microscope used by examiners having different professional experience. One hundred and sixty extracted premolars and molars with varying degrees of proximal caries or sound surfaces were embedded in 10 pairs of models with proximal tooth contacts and a simulated gingiva mask. The proximal surfaces were visually evaluated by 14 observers (7 students, 7 dentists) according to a 5-point caries rating scale using a head-worn prism loupe (x4.5), a surgical microscope (x 14) and without any magnifying device (control). The validity of observations was expressed as ROC curves calculated for two gold standard thresholds: (a) the presence of caries and (b) macroscopic cavitation. Repeated measures analysis of variance was used to determine the effects of 'observer group' and 'diagnostic modality'. An influence of the observer group could not be demonstrated (p > 0.72), whereas significant differences were revealed between the diagnostic modalities (p caries detection with magnifying aids were smaller compared to the control group. It was concluded that the use of a prism loupe or a surgical microscope does not improve the validity of proximal caries detection if the operators, irrespective of being dental students or clinical instructors, are inexperienced in its utilisation. In general only moderate validity was achieved with visual inspection of proximal sites. Copyright 2002 S. Karger AG, Basel

  7. Proximity strategies in outsourcing relations: the role of geographical, cultural and relational proximity in the European automotive industry

    OpenAIRE

    Schmitt, Alexander; Van Biesebroeck, Jo

    2013-01-01

    Several trends that affect the manufacturing of sophisticated goods - increasing international fragmentation of production, and lean and modular process technologies - have increased the importance of proximity in the supply chain. We use the case of the European automotive industry to simultaneously evaluate the relative importance of three dimensions: geographical, cultural, and relational proximity. Using a rich and novel data set, we find that carmakers value some aspects of each dimensio...

  8. Minimally invasive plate osteosynthesis for proximal humeral fractures.

    Science.gov (United States)

    Koljonen, Paul Aarne; Fang, Christian; Lau, Tak Wing; Leung, Frankie; Cheung, Nigel W K

    2015-08-01

    To report the outcome after minimally invasive plate osteosynthesis (MIPO) through the deltoid-splitting approach for proximal humeral fractures. 10 men and 30 women aged 37 to 88 years underwent MIPO through the deltoid-splitting approach using the Proximal Humerus Internal Locking System or the Locking Proximal Humerus Plate for 2-part (n=18), 3-part (n=20), and 4-part (n=2) proximal humeral fractures. The rehabilitation protocol was standardised. All 40 patients were followed up at 3 months, 34 (85%) at 6 months, 30 (75%) at one year, and 13 (33%) at 2 years. Two patients had malunion. No patient had avascular necrosis, infection, nerve palsy, or nonunion. The mean Constant score at one year and 2 years was 75 and 87.5, respectively. The Constant score at 6 months correlated to that at one year (r=0.926, pfracture grade, or hand dominance. MIPO for fixation of proximal humeral fractures using a locking plate is safe and effective in enabling an early return of shoulder function.

  9. The Applications of Finite Element Analysis in Proximal Humeral Fractures

    Science.gov (United States)

    Ye, Yongyu; You, Wei; Zhu, Weimin; Cui, Jiaming; Chen, Kang

    2017-01-01

    Proximal humeral fractures are common and most challenging, due to the complexity of the glenohumeral joint, especially in the geriatric population with impacted fractures, that the development of implants continues because currently the problems with their fixation are not solved. Pre-, intra-, and postoperative assessments are crucial in management of those patients. Finite element analysis, as one of the valuable tools, has been implemented as an effective and noninvasive method to analyze proximal humeral fractures, providing solid evidence for management of troublesome patients. However, no review article about the applications and effects of finite element analysis in assessing proximal humeral fractures has been reported yet. This review article summarized the applications, contribution, and clinical significance of finite element analysis in assessing proximal humeral fractures. Furthermore, the limitations of finite element analysis, the difficulties of more realistic simulation, and the validation and also the creation of validated FE models were discussed. We concluded that although some advancements in proximal humeral fractures researches have been made by using finite element analysis, utility of this powerful tool for routine clinical management and adequate simulation requires more state-of-the-art studies to provide evidence and bases. PMID:29081829

  10. The Applications of Finite Element Analysis in Proximal Humeral Fractures

    Directory of Open Access Journals (Sweden)

    Yongyu Ye

    2017-01-01

    Full Text Available Proximal humeral fractures are common and most challenging, due to the complexity of the glenohumeral joint, especially in the geriatric population with impacted fractures, that the development of implants continues because currently the problems with their fixation are not solved. Pre-, intra-, and postoperative assessments are crucial in management of those patients. Finite element analysis, as one of the valuable tools, has been implemented as an effective and noninvasive method to analyze proximal humeral fractures, providing solid evidence for management of troublesome patients. However, no review article about the applications and effects of finite element analysis in assessing proximal humeral fractures has been reported yet. This review article summarized the applications, contribution, and clinical significance of finite element analysis in assessing proximal humeral fractures. Furthermore, the limitations of finite element analysis, the difficulties of more realistic simulation, and the validation and also the creation of validated FE models were discussed. We concluded that although some advancements in proximal humeral fractures researches have been made by using finite element analysis, utility of this powerful tool for routine clinical management and adequate simulation requires more state-of-the-art studies to provide evidence and bases.

  11. Intramedullary Nailing for Pathological Fractures of the Proximal Humerus.

    Science.gov (United States)

    Choi, Eun-Seok; Han, Ilkyu; Cho, Hwan Seong; Park, In Woong; Park, Jong Woong; Kim, Han-Soo

    2016-12-01

    Endoprosthetic reconstruction is widely applied for pathological fractures of the proximal humerus; however, functional impairment is usually unsatisfactory. The aims of the current study are to evaluate the reliability of interlocking intramedullary (IM) nailing with cement augmentation as a fixation method in proximal humeral lesions and to assess functional outcomes. We reviewed 32 patients with pathological fractures of the proximal humerus who underwent interlocking IM nailing and cement augmentation. Functional scores and pain relief were assessed as outcomes. The mean follow-up period was 14.2 months. The mean Musculoskeletal Tumor Society functional score and Karnofsky performance status scale score were 27.7 and 75.6, respectively. Improvement of pain assessed using the visual analogue scale was 6.2 on average. Thirty-one patients (97%) experienced no pain after surgery. The mean ranges of forward flexion and abduction were 115° and 112.6°, respectively. All patients achieved stability and had no local recurrence without failure of fixation until the last follow-up. Proximal interlocking IM nailing with cement augmentation appears to be a reliable treatment option for pathological or impending fractures of the proximal humerus in selected patients with metastatic tumors, even with extensive bone destruction.

  12. FUNCTIONAL OUTCOME OF PHILOS PLATE FIXATION FOR PROXIMAL HUMERUS FRACTURES

    Directory of Open Access Journals (Sweden)

    Ch. Venkateswarlu

    2016-01-01

    Full Text Available INTRODUCTION Treating a proximal humerus fracture remained a challenging problem until proximal humeral internal locking system has been developed. Our study aims at evaluating the functional outcome of 30 consecutive patients with proximal humeral fracture treated by Philos plate fixation; 30 patients with proximal humeral fractures who attended our hospital between December 2013 and December 2015 were included in the study; 18 women and 12 men with a mean age of 47.5years (30-60 years are included. Data was collected prospectively and outcomes were assessed using constant shoulder score. The mean follow-up period was 12 months (6-18 months. Mean union time of all the fractures was 11.4 weeks (8-20 weeks. The mean constant shoulder score at final review was 70.5 (52-92. Philos plate provides stable fracture fixation for proximal humerus fracture in both young and elderly patients, which enables for early mobilisation and achieves acceptable functional results.

  13. Topology of digital images visual pattern discovery in proximity spaces

    CERN Document Server

    Peters, James F

    2014-01-01

    This book carries forward recent work on visual patterns and structures in digital images and introduces a near set-based a topology of digital images. Visual patterns arise naturally in digital images viewed as sets of non-abstract points endowed with some form of proximity (nearness) relation. Proximity relations make it possible to construct uniform topolo- gies on the sets of points that constitute a digital image. In keeping with an interest in gaining an understanding of digital images themselves as a rich source of patterns, this book introduces the basics of digital images from a computer vision perspective. In parallel with a computer vision perspective on digital images, this book also introduces the basics of prox- imity spaces. Not only the traditional view of spatial proximity relations but also the more recent descriptive proximity relations are considered. The beauty of the descriptive proximity approach is that it is possible to discover visual set patterns among sets that are non-overlapping ...

  14. Results of the proximal humerus endoprosthetic reconstruction after tumour resection

    Directory of Open Access Journals (Sweden)

    I. M. Mikailov

    2014-01-01

    Full Text Available The purpose of the study was to evaluate the results of surgical reconstructions of the proximal humerus after transarticular tumour resection, compare the functional results with the results of shoulder arthroplasty in patients with extensive damage of the proximal humerus of non-neoplastic origin. Material and methods. Between 2001 and 2013 38 proximal humeral reconstructions were performed in our clinic: using monopolar endoprostheses - 26 (68% and modular systems with reversible head -12 (32%. The control group included 46 patients with extensive lesions of the proximal humerus of non-neoplastic origin, operated in our clinic in the period from 2006 to 2012. Term follow-up of patients ranged from 7 months to 9 years. Assessment of functional results was carried out in a period from six months to one year. Results. The seven-year survival according the Kaplan - Meier method for patients with primary malignant tumors of the proximal humerus (25 patients was 77%. In the study group the average value of functional outcome MSTS score was 77.7%. Unipolar prosthesis showed a bad result, both in the control (61,3% MSTS, 60,7 Neer and in the main (67,7% MSTS, 61,1 Neer study groups. Conclusion. Currently the method of choice which doesn’t impair the oncologic component of treatment patients with shoulder neoplastic lesions is its replacement with modular reversible systems in combination with additional soft tissue fixation.

  15. Clinical applicability of resin infiltration for proximal caries.

    Science.gov (United States)

    Altarabulsi, Mohammad Basel; Alkilzy, Mohammad; Splieth, Christian H

    2013-02-01

    Resin infiltration is a new microinvasive treatment to arrest the progress of proximal initial caries lesions. This study evaluated the clinical applicability of proximal caries infiltration. In the study population of 50 children, adolescents, and young adults (mean age, 17.3 ± 6.4 years), 10 dentists at the University of Greifswald, Greifswald, Germany, applied the infiltration material Icon on noncavitated proximal lesions in permanent and primary teeth as described by the manufacturer. The applicability was evaluated using two questionnaires filled out by clinicians and patients assessing the comfort, complexity, time, and difficulties of the application in comparison to a filling. The results showed good patient satisfaction with the procedure. The mean time for infiltration (24.3 ± 7.4 minutes), which included rubber dam application (7.7 ± 4 minutes) and the effort were perceived to be comparable to or even easier than a composite filling by clinicians. In three patients (6%), it was not possible to gain sufficient proximal space for the application of an infiltration. The location of the infiltrated tooth, separation problems, and the routine of clinicians with the infiltration technique had an effect on the duration of the infiltration. A clear learning curve with a reduction of treatment time for subsequent treatments was observed (P proximal lesion showed good clinical applicability for clinicians and very high acceptance by patients.

  16. The Proximity Cryogenic System for the ATLAS Toroidal Magnets

    CERN Document Server

    Baynham, D Elwyn; Brown, G; Cragg, D; Crook, M; Haug, F; Mayri, C; Orlowska, A H; Passardi, Giorgio; Pengo, R; ten Kate, H H J; Rochford, J; Sole, D

    2002-01-01

    ATLAS is a very high-energy detector for the Large Hadron Collider (LHC) at CERN. The superconducting magnet used to provide the required magnetic field consists of four sub-systems: a central solenoid and a very large toroidal magnet comprising two end-cap magnets and the barrel toroid magnet. The associated cryogenic system, currently in the final specification and procurement phase has been sub-divided into three parts: internal, proximity and external. The internal cryogenics minimizes and extracts the heat loads to/from the 4.5 K cold mass and its thermal shields, while the proximity cryogenics takes the cooling capacity generated by the external common system and distributes it to the four magnets according to the various operating scenarios. Two independent proximity cryogenic systems have been designed taking into account the difference in cooling principle of the solenoid and the three toroids, respectively.

  17. The proximity cryogenic system for the ATLAS toroidal magnets

    Science.gov (United States)

    Haug, F.; Passardi, G.; Pengo, R.; ten Kate, H.; Baynham, E.; Bradshaw, T.; Brown, G.; Cragg, D.; Crook, M.; Orlowska, A. H.; Rochford, J.; Sole, D.; Mayri, C.

    2002-05-01

    ATLAS is a very high-energy detector for the Large Hadron Collider (LHC) at CERN. The superconducting magnet used to provide the required magnetic field consists of four sub-systems: a central solenoid and a very large toroidal magnet comprising two end-cap magnets and the barrel toroid magnet. The associated cryogenic system, currently in the final specification and procurement phase has been sub-divided into three parts: internal, proximity and external. The internal cryogenics minimizes and extracts the heat loads to/from the 4.5 K cold mass and its thermal shields, while the proximity cryogenics takes the cooling capacity generated by the external common system and distributes it to the four magnets according to the various operating scenarios. Two independent proximity cryogenic systems have been designed taking into account the difference in cooling principle of the solenoid and the three toroids, respectively.

  18. How to improve outcome in surgery for Proximal Hypospadias?

    Science.gov (United States)

    Qureshi, Abdul Hafeez; Zaidi, Syed Zafar

    2016-02-01

    To evaluate the role of subdartos fascial tissue as watertight layer in improving outcome for 2-stage proximal hypospadias surgery. The experimental study was conducted at the Department of Urology, Indus Hospital, Karachi, and comprised an audit of patients with proximal hypospadias who underwent surgery from July 1, 2007, to December 31, 2011. The initial two-stage repair of proximal hypospadias led to a high rate of urethrocutanous fistula formation (Group A), and, thus, a modification was introduced and subdartos facial double layer was applied over the urethral suture line (Group B). The results were compared regarding age, type of hypospadias, graft failure and urethrocutanous fistula in these patients. There were 27 patients in Group A and 16(59.3%) of them ended up having urethrocutanous fistula. Group B had 25 patients and only 2(8%) had fistula formation. The application of dartos facial flap waterproofing layer reduced fistula rate.

  19. Specifics of proximal caries and their diagnostics in posterior teeth

    Directory of Open Access Journals (Sweden)

    Wojcik-Checinska Ilona

    2015-06-01

    Full Text Available Proximal surfaces are the second in turn after the occlusal surfaces, as being the most exposed places to the carious process. The specificity of changes and location makes the diagnostic of approximal cavities difficult. The aim of the study was to collect information on possibilities of detection, monitoring and assessment of carious lesions located on proximal surfaces, starting from the early stage. On the base of current literature, chosen methods of diagnosis, from conventional, to advanced technologies were presented. Current literature also suggests that none of the diagnostic methods exclude the possibility of misdiagnosis of proximal caries. Therefore, during the diagnosing of doubtful cases, it is advisable to employ several methods of assessment, with simultaneous individual appraisal of caries risk factors, such as oral hygiene, frequency of eating sweets or the number of active caries foci.

  20. Cilastatin attenuates cisplatin-induced proximal tubular cell damage.

    Science.gov (United States)

    Camano, Sonia; Lazaro, Alberto; Moreno-Gordaliza, Estefania; Torres, Ana M; de Lucas, Carmen; Humanes, Blanca; Lazaro, Jose A; Milagros Gomez-Gomez, M; Bosca, Lisardo; Tejedor, Alberto

    2010-08-01

    A major area in cancer therapy is the search for protective strategies against cisplatin-induced nephrotoxicity. We investigated the protective effect of cilastatin on cisplatin-induced injury to renal proximal tubular cells. Cilastatin is a specific inhibitor of renal dehydrodipeptidase I (DHP-I), which prevents hydrolysis of imipenem and its accumulation in the proximal tubule. Primary cultures of proximal cells were treated with cisplatin (1-30 microM) in the presence or absence of cilastatin (200 microg/ml). Apoptosis and mitochondrial injury were assessed by different techniques. Cisplatin uptake and DNA binding were measured by inductively coupled plasma spectrometry. HeLa cells were used to control the effect of cilastatin on the tumoricidal activity of cisplatin. Cisplatin increased cell death, apoptotic-like morphology, caspase activation, and mitochondrial injury in proximal tubular cells in a dose- and time-dependent way. Concomitant treatment with cilastatin reduced cisplatin-induced changes. Cilastatin also reduced the DNA-bound platinum but did not modify cisplatin-dependent up-regulation of death receptors (Fas) or ligands (tumor necrosis factor alpha, Fas ligand). In contrast, cilastatin did not show any effects on cisplatin-treated HeLa cells. Renal DHP-I was virtually absent in HeLa cells. Cilastatin attenuates cisplatin-induced cell death in proximal tubular cells without reducing the cytotoxic activity of cisplatin in tumor cells. Our findings suggest that the affinity of cilastatin for renal dipeptidase makes this effect specific for proximal tubular cells and may be related to a reduction in intracellular drug accumulation. Therefore, cilastatin administration might represent a novel strategy in the prevention of cisplatin-induced acute renal injury.

  1. One-stage surgical correction of proximal hypospadias.

    Science.gov (United States)

    Joseph, V T

    2003-01-01

    Proximal hypospadias poses major problems in surgical correction owing to the complexity and severity of the abnormalities, leading to the use of staged repairs to correct this condition. However, with precise definition of the components of this deformity a single-stage operation can be developed and applied successfully for surgical correction of this condition. Twenty-six patients with severe proximal hypospadias were subjected to a one-stage repair. Excision of proximal fibrotic dartos tissue and removal of dysplastic urethral plate tissue corrected chordee completely. Urethral reconstruction was then performed by tubularising a flap of dorso-lateral preputial skin which was then anastomosed to the proximal urethra. The glandular part of the urethra was reconstructed using the distal part of the flap as an onlay graft over the meatal groove. The suture lines were covered with a layer of dartos tissue and skin closure was completed by transposing dorsal skin to surface the ventral penile shaft. A urethral catheter was left in for 10 days. All patients have been followed up after surgery from 1 to 5 years with a median period of 2 years. There were no fistulas. Two patients had mild stenosis at the meatus which responded to dilatation. One patient developed a stricture at the proximal anastomosis which required secondary correction. All other patients achieved satisfactory correction, both in terms of voiding and in the cosmetic appearance of the genitalia. Single-stage repair of hypospadias can be successfully applied in the correction of severe proximal hypospadias. It requires meticulous dissection and careful design of reconstructive techniques. The end results are comparable to staged procedures and morbidity is significantly lower.

  2. Evolution of treatment of of the proximal humerus fractures (review

    Directory of Open Access Journals (Sweden)

    P. G. Kogan

    2013-01-01

    Full Text Available The article in generalized form acquaints with the publications devoted to the bases of proximal humeral fractures treatment. A brief digression on anatomy and biomechanics of the humeral joint allows to consider the main morphological features of it. The most commonly used classification of proximal humeral fractures concisely classify many types of damage. According to the clinical and anatomical characteristics of fractures tracked the historical aspect, the development and the current state of the most common methods of treatment. In his review collected works authors share their experience in the application of methods. It allows to further the perspective directions.

  3. Critical Proximity as a Methodological Move in Techno-Anthropology

    DEFF Research Database (Denmark)

    Birkbak, Andreas; Petersen, Morten Krogh; Elgaard Jensen, Torben

    2015-01-01

    echno-Anthropology is a new field, operating with a broad range of methodologies and approaches. This gives rise to the question: What does it mean for Techno-Anthropological research to be critical? In this paper, we discuss this question by developing and specifying the notion of ‘critical...... work through two cases—one on the involvement of users in innovation projects and another on commercial web technologies for tracing issues—to show how critical proximity may be practiced. We sum up the lessons derived in four methodological guidelines for doing research with critical proximity....

  4. Improving outcomes for patients with proximal femoral fractures.

    Science.gov (United States)

    Shah, Dipal; Dhillon, Amritpaul; Mulvaney, Emily; Robinson, Margaret; Weerasuriya, Namal

    2014-09-25

    A peri-operative bay was created to treat all patients with proximal femoral fractures admitted to one trauma ward at the Queen's Medical Centre, Nottingham. All patients had urinary catheterisation and their fluid intake and output was recorded; patients had daily blood tests and were cared for on pressure-relieving mattresses. In addition, a study day was provided for all nursing staff on the management of patients with proximal femoral fractures. These measures resulted in a significant decrease in the incidence of acute kidney injury, reduced the length of hospital stay for patients on this ward and reduced the numbers of falls and pressure-related injuries for these patients.

  5. Bizarre parosteal osteochondromatous proliferation of the proximal humerus: case report

    Energy Technology Data Exchange (ETDEWEB)

    Bush, J.B.; Meyer, Mark S. [Ochsner Clinic Foundation, Department of Orthopedics, New Orleans, LA (United States); Reith, John D. [University of Florida College of Medicine, Departments of Pathology, Immunology and Laboratory Medicine and Orthopaedics and Rehabilitation, Gainesville, Florida (United States)

    2007-06-15

    Bizarre parosteal osteochondromatous proliferation (BPOP), or Nora's lesion, is a rare lesion of bone occurring predominantly in the long bones of the hands and feet. It exists as a puzzling clinical entity of uncertain origins and high recurrence rates after surgical resection. To our knowledge, this clinical entity has not been reported in the proximal aspect of the humerus. An interesting report of a lesion occurring in the proximal humerus, which initially was misinterpreted as a parosteal osteosarcoma, is discussed outlining the clinical, radiographic and pathologic features of the BPOP lesion. (orig.)

  6. Proximal antecedents to violent events in adolescent dating relationships.

    Science.gov (United States)

    Stephenson, Pamela S; Martsolf, Donna S; Draucker, Claire Burke

    2011-01-01

    Dating violence affects 25-60% of adolescents. This study developed a typology of proximal antecedents to violent events in adolescent dating relationships. Descriptions of 307 dating violence events were extracted from transcribed interviews with 87 young adults who experienced dating violence as adolescents. Verbatim text preceding the description of each violent event was identified as a proximal antecedent. Cross-case analysis was used to develop a typology of five antecedent categories: "pulling away,"  "demanding obedience," "discovering involvement with a rival," "defining the relationship," "demonstrating disrespect." Practitioners can use this typology to engage teens in discussions of factors that precede dating violence events.

  7. Modelling and Analysis of Proximity Effect in IGBT Fuses

    DEFF Research Database (Denmark)

    Iov, Florin; Blaabjerg, Frede; Rasmussen, Henrik

    2005-01-01

    . Even with an active protection, a high power IGBT still has a risk of exhibiting a violent rupture in the case of a fault if e.g. IGBT fuses are not protecting it. By introducing fuses into voltage source converters a better protection of IGBT's can be achieved. However, skin and proximity effects...... affect the current distribution in a fuse due to the high frequency currents and thus a need for de-rating the fuse. This paper shows an analytical model for studying the proximity effect into a fuse. The results obtained using this model are compared with experiments....

  8. Efficient Indoor Proximity and Separation Detection for Location Fingerprinting

    DEFF Research Database (Denmark)

    Kjærgaard, Mikkel Baun; Treu, Georg; Ruppel, Peter

    2008-01-01

    Detecting proximity and separation among mobile targets is a basic mechanism for many location-based services (LBSs) and requires continuous positioning and tracking. However, realizing both mechanisms for indoor usage is still a major challenge. Positioning methods like GPS cannot be applied there......, and for distance calculations the particular building topology has to be taken into account. To address these challenges, this paper presents a novel approach for indoor proximity and separation detection, which uses location fingerprinting for indoor positioning of targets and walking distances for modeling...

  9. Arthroscopic-assisted removal of proximal tibia locking plates

    Directory of Open Access Journals (Sweden)

    Gille Justus

    2012-05-01

    Full Text Available Abstract We present a new technique to remove plates from the proximal tibia arthroscopic-assisted with all advantages of the minimally invasive surgery and the possibility to treat concomitant intraarticular pathologies. The initial results (n = 7 are promising with an increase of the Lysholm score in all cases studied [preop. median 78 (range 32–100, postop. median 89 (range 60–100]. In conclusion, arthroscopic-assisted hardware removal at the proximal tibia is feasible and may provide patients with all the benefits of minimal-invasive hardware removal. The described technique can be recommended for all surgeons familiar with arthroscopic surgery.

  10. Longitudinal spin Seebeck effect free from the proximity Nernst effect.

    Science.gov (United States)

    Kikkawa, T; Uchida, K; Shiomi, Y; Qiu, Z; Hou, D; Tian, D; Nakayama, H; Jin, X-F; Saitoh, E

    2013-02-08

    This Letter provides evidence for intrinsic longitudinal spin Seebeck effects (LSSEs) that are free from the anomalous Nernst effect (ANE) caused by an extrinsic proximity effect. We report the observation of LSSEs in Au/Y(3)Fe(5)O(12) (YIG) and Pt/Cu/YIG systems, showing that the LSSE appears even when the mechanism of the proximity ANE is clearly removed. In the conventional Pt/YIG structure, furthermore, we separate the LSSE from the ANE by comparing the voltages in different magnetization and temperature-gradient configurations; the ANE contamination was found to be negligibly small even in the Pt/YIG structure.

  11. Proximal focal humeral deficiency in a large breed dog.

    Science.gov (United States)

    Kalff, S; Gemmill, T

    2012-01-01

    A 26-week-old female Boerboel was referred for evaluation of progressive left thoracic limb lameness. Computed tomography and radiographic evaluation revealed radiolucency of the caudal region of the proximal humeral metaphysis, absence of the humeral head, and gross distortion of the glenoid. Given the severe glenohumeral deformation, arthrodesis of the left shoulder was performed using orthogonal locking bone plates, lag screw fixation, and bone grafting. Despite late implant failure, arthrodesis was successful in this case, and satisfactory limb function was restored. To the author's knowledge, this is the first report of a case of a focal developmental deficiency of the proximal humerus reported in a dog.

  12. Proximity Operations Nano-Satellite Flight Demonstration (PONSFD) Rendezvous Proximity Operations Design and Trade Studies

    Science.gov (United States)

    Griesbach, J.; Westphal, J. J.; Roscoe, C.; Hawes, D. R.; Carrico, J. P.

    2013-09-01

    The Proximity Operations Nano-Satellite Flight Demonstration (PONSFD) program is to demonstrate rendezvous proximity operations (RPO), formation flying, and docking with a pair of 3U CubeSats. The program is sponsored by NASA Ames via the Office of the Chief Technologist (OCT) in support of its Small Spacecraft Technology Program (SSTP). The goal of the mission is to demonstrate complex RPO and docking operations with a pair of low-cost 3U CubeSat satellites using passive navigation sensors. The program encompasses the entire system evolution including system design, acquisition, satellite construction, launch, mission operations, and final disposal. The satellite is scheduled for launch in Fall 2015 with a 1-year mission lifetime. This paper provides a brief mission overview but will then focus on the current design and driving trade study results for the RPO mission specific processor and relevant ground software. The current design involves multiple on-board processors, each specifically tasked with providing mission critical capabilities. These capabilities range from attitude determination and control to image processing. The RPO system processor is responsible for absolute and relative navigation, maneuver planning, attitude commanding, and abort monitoring for mission safety. A low power processor running a Linux operating system has been selected for implementation. Navigation is one of the RPO processor's key tasks. This entails processing data obtained from the on-board GPS unit as well as the on-board imaging sensors. To do this, Kalman filters will be hosted on the processor to ingest and process measurements for maintenance of position and velocity estimates with associated uncertainties. While each satellite carries a GPS unit, it will be used sparsely to conserve power. As such, absolute navigation will mainly consist of propagating past known states, and relative navigation will be considered to be of greater importance. For relative observations

  13. Us gaap x normas brasileiras: mensuração do impacto das diferenças de normas no lucro duplamente reportado pelas empresas brasileiras emissoras de adrs na nyse

    Directory of Open Access Journals (Sweden)

    Edilene Santana Santos

    2011-01-01

    Full Text Available A falta de um conjunto único de normas contábeis válido para todos os países pode conduzir a resultados conflitantes. Por exemplo, entre as emissoras brasileiras de ADRs (American Depositary Receipts na NYSE (New York Stock Exchange, a CEMIG apresentou em 2002 um prejuízo de R$ 12 milhões conforme as normas americanas (US GAAP e, sob as normas brasileiras, um prejuízo de R$ 1 bilhão (ou seja, 83 vezes maior. Também a CSN apresentou no mesmo ano um lucro de R$ 6 milhões conforme os US GAAP (United States Generally Accepted Accounting Principles, contra um prejuízo de R$ 218 milhões conforme as normas brasileiras (ou seja, 30 vezes maior. Este estudo objetiva verificar se diferenças entre as normas contábeis brasileira e norte-americana (US GAAP geram impacto significativo no resultado duplamente reportado no Formulário 20F pelas 30 emissoras brasileiras de ADRs na NYSE. Para mensurar o efeito dessas diferenças normativas no resultado foi utilizado o “Índice de Conservadorismo” (IC de Gray, que mede o quanto um sistema contábil nacional gera lucros menores (“é conservador” ou maiores (“é otimista” em relação aos US GAAP. A média e a mediana do IC no período 2001 a 2005 indicaram conservadorismo das normas brasileiras, não confirmado pelo teste t-Student, mas corroborado pelo teste de Wilcoxon a 10% de significância. Dividindo-se em dois subperíodos, obteve-se um IC médio de 1,2 para 2001-2002 (significativo a 3,3% e de 0,86 para 2003-2005 (significativo a 3%, indicando uma disparidade de comportamento: a contabilidade brasileira mostra-se mais otimista que os US GAAP até 2002, passando a mais conservadora a partir de 2003 até 2005.

  14. The theoretical simulation on electrostatic distribution of 1st proximity region in proximity focusing low-light-level image intensifier

    Science.gov (United States)

    Zhang, Liandong; Bai, Xiaofeng; Song, De; Fu, Shencheng; Li, Ye; Duanmu, Qingduo

    2015-03-01

    Low-light-level night vision technology is magnifying low light level signal large enough to be seen by naked eye, which uses the photons - photoelectron as information carrier. Until the micro-channel plate was invented, it has been possibility for the realization of high performance and miniaturization of low-light-level night vision device. The device is double-proximity focusing low-light-level image intensifier which places a micro-channel plate close to photocathode and phosphor screen. The advantages of proximity focusing low-light-level night vision are small size, light weight, small power consumption, no distortion, fast response speed, wide dynamic range and so on. It is placed parallel to each other for Micro-channel plate (both sides of it with metal electrode), the photocathode and the phosphor screen are placed parallel to each other. The voltage is applied between photocathode and the input of micro-channel plate when image intensifier works. The emission electron excited by photo on the photocathode move towards to micro-channel plate under the electric field in 1st proximity focusing region, and then it is multiplied through the micro-channel. The movement locus of emission electrons can be calculated and simulated when the distributions of electrostatic field equipotential lines are determined in the 1st proximity focusing region. Furthermore the resolution of image tube can be determined. However the distributions of electrostatic fields and equipotential lines are complex due to a lot of micro-channel existing in the micro channel plate. This paper simulates electrostatic distribution of 1st proximity region in double-proximity focusing low-light-level image intensifier with the finite element simulation analysis software Ansoft maxwell 3D. The electrostatic field distributions of 1st proximity region are compared when the micro-channel plates' pore size, spacing and inclination angle ranged. We believe that the electron beam movement

  15. Depressionary Effect of Proximity of Residential Properties to Waste ...

    African Journals Online (AJOL)

    Depressionary Effect of Proximity of Residential Properties to Waste Disposal Sites in Nigeria. ... a helpful Frequently Asked Questions about PDFs. Alternatively, you can download the PDF file directly to your computer, from where it can be opened using a PDF reader. To download the PDF, click the Download link above.

  16. PROXIMAL RADIUS RECONSTRUCTION BY METATARSAL OSTEOCHONDRAL AUTO GRAFT

    Directory of Open Access Journals (Sweden)

    Kammar

    2015-04-01

    Full Text Available 17 Year Old student, Pavan presents with swelling since 8 months. Swelling was diffuse over forearm. Tenderness was present. No local rise of temperature. Range of m ovement at elbow was restricted and painful terminally. No distal neurovascular deficits. X - ray reveale d it to be an a neurysmal bone cyst of proximal right radius. FNAC showed Aneurysmal bone cyst for which curettage and bone grafting was done. Post 6 months tumour recurred with a swelling around upper third of right fo rearm. FNAC and J - needle biopsy showed it to be a neurysmal bone cyst. MRI showed ABC of proximal radius without soft tissue involvement. Excision of proximal third of radius with reconstruction by 3 rd metatarsal and augmented with fib ular graft and stabili zed with dynamic c ompression plate and screws . Tumour specimen was sent for h istopathology a t 2 weeks p ost operatively patient had good range of movements. At present patient has full range of flexion , extension , supination & pronation . He is able to carry out his ADL. In the literature proximal radius reconstruction has been tried in traumatic communited radial head fractures. Here it done for r ecurrent benign tumour like aneurysmal bone cyst, as the base of 3rd metatarsal anatomically coincides with radial head and hence a better radio - capital articulation

  17. outcome of plate osteosynthesis in the management of proximal

    African Journals Online (AJOL)

    through decreased bone mineral density, disruption of bone micro-architecture and reduction in non- collagenous proteins. Proximal humerus fractures are difficult to manage, particularly in the osteoporotic bone, where the fracture is usually .... is followed by pendulum shoulder exercises which gradually graduate to active ...

  18. Proximate analysis and total lycopene content of some tomato ...

    African Journals Online (AJOL)

    Standard analytical techniques were employed to determine the proximate composition and lycopene content of three tomato cultivars namely: Roma VF, Ronita and UTC grown in six local government areas of Kano state, Nigeria. Results indicated mean values of 0.15±0.03, 0.16±0.01, 0.15±0.01% titratable acidity; ...

  19. Case report of LCP pediatric hip osteosynthesis of a proximal ...

    African Journals Online (AJOL)

    We present a case report demonstrating the experience of the department of pediatric orthopaedics of the University Orthopedic Hospital at Sofia Medical University in the treatment of an intertrochanteric proximal femoral fracture in a child with osteopetrosis. We performed open fracture reduction with stable 120° LCP ...

  20. Quality Assessment and Proximate Analysis of Amaranthus hybridus ...

    African Journals Online (AJOL)

    user

    ABSTRACT: The aim of this research is to determine the quality and proximate composition of. Amaranthus hybridus, Celosia argentea, and Talinum triangulare obtained from open .... Vegetable microbiota is very diverse and vegetable quality and safety depend on many factors, including soil, fertilizer, irrigation water, ...

  1. Noncycling mappings and best proximity pair results in Hilbert and ...

    African Journals Online (AJOL)

    A new class of noncyclic mappings, called generalized noncyclic relatively nonexpansive, is introduced and used to study the existence of best proximity pairs in the setting of uniformly convex Banach spaces. We also obtain a weak convergence theorem for noncyclic relatively nonexpansive mappings in the setting of ...

  2. Two Stages repair of proximal hypospadias: Review of 33 cases

    African Journals Online (AJOL)

    HussamHassan

    It decreases the rate of fistula formation; disruption; stenosis and gives a satisfactory cosmetic appearance. Index Word: proximal hypospadias, two stages repair. ... Second procedure: a) formation of the neo-urethra, b) skin closure, c) dressing. Complete degloving of the penile shaft was performed till its base. Then artificial ...

  3. Fractures of the proximal humerus in children and adolescents

    Directory of Open Access Journals (Sweden)

    Ruban Raj Joshi, Dr

    2013-12-01

    Full Text Available Background: In most children proximal humeral fractures are treated non-operatively with generally good results. The aim of the study was to evaluate the clinical outcome of closed/open reduction in children with severely displaced proximal humeral fractures. Materials and Methods: The charts of 15 patients (8 girls and 7 boys; mean age: 9.4 years with proximal humeral fractures who were managed at our institution were reviewed from October 2011 to December 2013. Results: There were 7 metaphyseal fractures and 8 physeal injuries which were angulated according to Neer-Horowitz score as grade II (n=2, grade III(n=4 and grade IV(n=9. Associated lesions comprised open fracture with head trauma in a 2 year old female child which was operated on primarily and the 14 others by secondary intention. All patients were treated surgically with either closed (n = 5 or open (n=10 reduction and internal fixation with Kirschner wire or titanium elastic nails (TENs. They were assessed for clinical and radiological healing at a mean follow up of 1.25 years ranging from 0.5 to 2.0 years. Conclusion: Surgical option is indicated for severely displaced and unstable fractures in older children and adolescents. In addition to the periosteum , long head of the biceps, deltoid muscle, and bone fragments in combination can prevent fracture reduction. Key words: Proximal humerus fracture, Children, Open reduction, Operative.

  4. Proximate composition and amino acid profile of rice husk ...

    African Journals Online (AJOL)

    Native rice husk (NRH) was fermented with Pleurotus ostreatus for 7, 14 and 21 days to improve the nutritional values. The proximate composition and amino acid profiles were determined. The results showed that crude fibre (CF), nitrogen free extract (NFE), acid detergent fibre (ADF), and neutral detergent fibre (NDF) were ...

  5. Proximate composition of traditional local sorghum beer “dolo ...

    African Journals Online (AJOL)

    Dolo is a local beer manufactured from malted sorghum grains. It is the most commonly consumed alcoholic beverage in Burkina Faso (60% of population). Thirty (30) samples of dolo were collected from local markets in Ouagadougou and analyzed with respect to their proximate compositions and pH values using ...

  6. Effect of cooking method on proximate and mineral composition of ...

    African Journals Online (AJOL)

    This study investigated effect(s) of cooking fresh fish (Lake Malawi tilapia) by boiling, roasting, pan frying and, using a locally made fireless cooker) on its proximate (protein, fat, ash and moisture) and mineral (calcium, magnesium, zinc, iron and phosphorus) composition. Highest and lowest values for crude protein were ...

  7. Proximate composition of some agricultural wastes in Nigeria and ...

    African Journals Online (AJOL)

    The proximate composition of five agricultural wastes were determined and latter subjected to low temperature conversion process in the presence of nitrogen atmosphere.These agricultural wastes are Cocos nucifera husk,Theobroma cacao pod, Kola nitida pods and Plantago major peels(ripe and unripe peels). All the ...

  8. Proximal focal femoral deficiency in Ibadan a developing country's ...

    African Journals Online (AJOL)

    Prof Ezechukwu

    2011-06-09

    Jun 9, 2011 ... The major problems are limb length inequality and variable inadequacy of the proximal femoral musculature and hip joint. Treatment is indicated and ranges from amputation and prosthetic rehabilitation to limb salvage, lengthening, and hip re- construction. Until the early 1960s, treatment for PFFD at the St.

  9. Using an index of habitat patch proximity for landscape design

    Science.gov (United States)

    Eric J. Gustafson; George R. Parker

    1994-01-01

    A proximity index (PX) inspired by island biogeography theory is described which quantifies the spatial context of a habitat patch in relation to its neighbors. The index distinguishes sparse distributions of small habitat patches from clusters of large patches. An evaluation of the relationship between PX and variation in the spatial characteristics of clusters of...

  10. Proximate and mineral composition of Tamarindus indica linn 1753 ...

    African Journals Online (AJOL)

    Science World Journal ... Physical parameters and nutrient contents of the whole seeds and seed nuts of Tamarindus indica L. 1753 were determined. ... were found to be potential sources of mineral elements while the whole seeds were richer in other proximate components with the exception of moisture and ash contents.

  11. Private and Flexible Proximity Detection in Mobile Social Networks

    DEFF Research Database (Denmark)

    Siksnys, Laurynas; Thomsen, Jeppe Rishede; Saltenis, Simonas

    2010-01-01

    A privacy-aware proximity detection service determines if two mobile users are close to each other without requiring them to disclose their exact locations. Existing proposals for such services provide weak privacy, give low accuracy guarantees, incur high communication costs, or lack flexibility...

  12. Comparative physico-chemical and proximate analysis of oils of ...

    African Journals Online (AJOL)

    In rural areas of developing countries like Burkina Faso, nutritive elements are mainly composed of vegetable source. Shea nut, seeds of Sesamum indicum, Cucumis melo and Cucurbita pepo, four species widely consumed were studied. The proximate parameters: moisture, proteins and fat were analysed. Saponification ...

  13. Oscillations in the proximal intratubular pressure: a mathematical model

    DEFF Research Database (Denmark)

    Holstein-Rathlou, N H; Leyssac, P P

    1987-01-01

    This study presents a dynamic continuous time model of the regulation of the renal proximal intratubular pressure in the rat. The model integrates a functional model of the glomerulus, a tubular model, a feedback model, and an afferent arteriolar model. The model has one equilibrium solution for ...

  14. Levels and proximate determinants of fertility in Butajira District ...

    African Journals Online (AJOL)

    admin

    and child health services in Ethiopia were one of the main aims of the health extension program. The impediment of ... Objectives: This study aimed at measuring levels and fertility inhibition effects of proximate determinants in Butajira district. Methods: A ... its link to the success of reproductive health programs and policies ...

  15. Proximate analysis on four edible mushrooms | Adedayo | Journal of ...

    African Journals Online (AJOL)

    Proximate study was conducted on four edible mushrooms commonly found in farmlands in West Yagba Local Government Areas of Kogi state of Nigeria to ... The high fibre content make them a good source of roughages while their low acidity and alkalinity confirms their edibility and the fact that they are not likely to ...

  16. Seasonal variations in the proximate compositions of five ...

    African Journals Online (AJOL)

    Proximate compositions of five economically-important fish species from Lake Victoria and Lake Tanganyika, Tanzania were determined using standard methods and procedures of the Association of the Analytical Chemists. Samples of Lates niloticus, Oreochromis niloticus, Rastrineobola argentea, Limnothrissa miodon ...

  17. Two stages repair of proximal hypospadias: Review of 700 cases

    Directory of Open Access Journals (Sweden)

    Arvind Kumar Shukla

    2017-01-01

    Conclusion: Two stages procedure using the principles of Byar's technique is a versatile operation that can be used for 2 two-stage procedures the proximal hypospadias. It decreases the rate of fistula formation, disruption, and stenosis and gives a satisfactory cosmetic appearance.

  18. Proximate analysis of Sweet Potato Toasted Granules | Meludu ...

    African Journals Online (AJOL)

    Sweet potato is an important root crop in the food system of many African countries. The yield, nutrition and economic potential of sweet potato have been identified as very high. In this study, sweet potato was processed and toasted into granules. The proximate analysis performed on the toasted granules showed protein, ...

  19. Impact of Relational Proximity on Distress from Infidelity

    NARCIS (Netherlands)

    Fisher, Maryanne; Geher, Glenn; Cox, Anthony; Tran, Ulrich S.; Hoben, Ashley; Arrabaca, Andrew; Chaize, Corinna; Dietrich, Robert; Voracek, Martin

    2009-01-01

    Men are generally more distressed by a partner's sexual infidelity whereas women are generally more distressed by a partner's emotional infidelity. The importance of the identity of the interloper, however, has been neglected. We explored the influence of relational proximity (i.e., the degree of

  20. User's proximity effects for talk mode in mobile phones

    DEFF Research Database (Denmark)

    Pelosi, Mauro; B. Knudsen, Mikael; Pedersen, Gert Frølund

    Thanks to a recent grip study, 3D CAD model of the human hand have been generated, investigating user's proximity effects for talk mode in mobile phones. The simulation results show that the human hand exhibits a major contribution in determining the total loss when compared to the phantom head...

  1. Proximate composition of Mystus bleekeri in relation to body size ...

    African Journals Online (AJOL)

    Proximate composition of small catfish, Mystus bleekeri, from Nala Daik, Sialkot, Pakistan was investigated and fluctuation in relation to body size and condition factor was carried out. Mean percentages for water, fat, protein and ash contents in the whole wet body weight of wild M. bleekeri were 77.87, 3.26, 15.01 and ...

  2. 7383 EFFECT OF PROCESSING METHOD ON THE PROXIMATE ...

    African Journals Online (AJOL)

    Dr. Tilahun

    2013-04-02

    Apr 2, 2013 ... Although taro is widely grown in Ethiopia, it is an underutilized crop and little is known about its proximate and micro-element composition and the antinutritional factors of the raw, boiled and fermented products. Boiling and fermentation processing techniques are widely used in the country, especially ...

  3. Heavy metal and proximate composition associated with the ...

    African Journals Online (AJOL)

    User

    2014-05-08

    May 8, 2014 ... Changes in the heavy metal content and proximate composition during the 28 day composting of cassava peels used in the cultivation of the oyster mushrooms Pleurotus ostreatus strain EM-1 was studied. Significant dry weight variations of cellulose, hemicellulose and fat contents were observed from day ...

  4. Proximal femoral nail: a minimally invasive treatment for ...

    African Journals Online (AJOL)

    Materials and Methods: In our study patients who presented to department of orthopaedics, Katuri Medical College between January 2013 and December 2014, with intertrochanteric fractures were included and treated with Proximal Femoral Nail. Total of 82 patients were included in the study. Medically unfit patients and ...

  5. Comparative analysis of the Proximate composition and Sensory ...

    African Journals Online (AJOL)

    Comparative analysis of the Proximate composition and Sensory properties of dokuwa produced in Niger State Metropolis. ... Sensory evaluation of the samples on the basis of colour, texture, aroma, taste and overall acceptability showed that significant difference (p<0.05) existed between the samples. The sample from ...

  6. Do Proximate Micro-Swimmers Synchronize their Gait?

    CERN Document Server

    Yuan, Jinzhou; Raizen, David M; Bau, Haim H

    2012-01-01

    In this fluid dynamics video, we show that low Reynolds number swimmers, such as Caenorhabditis (C.) elegans, synchronize their gait when swimming in close proximity to maximize utilization of space. Synchronization most likely results from steric hindrance and enhances the propulsive speed only marginally.

  7. Proximity to coast is linked to climate change belief.

    Science.gov (United States)

    Milfont, Taciano L; Evans, Laurel; Sibley, Chris G; Ries, Jan; Cunningham, Andrew

    2014-01-01

    Psychologists have examined the many psychological barriers to both climate change belief and concern. One barrier is the belief that climate change is too uncertain, and likely to happen in distant places and times, to people unlike oneself. Related to this perceived psychological distance of climate change, studies have shown that direct experience of the effects of climate change increases climate change concern. The present study examined the relationship between physical proximity to the coastline and climate change belief, as proximity may be related to experiencing or anticipating the effects of climate change such as sea-level rise. We show, in a national probability sample of 5,815 New Zealanders, that people living in closer proximity to the shoreline expressed greater belief that climate change is real and greater support for government regulation of carbon emissions. This proximity effect held when adjusting for height above sea level and regional poverty. The model also included individual differences in respondents' sex, age, education, political orientation, and wealth. The results indicate that physical place plays a role in the psychological acceptance of climate change, perhaps because the effects of climate change become more concrete and local.

  8. Effect of Soaking Time on Proximate and Mineral Compositions and ...

    African Journals Online (AJOL)

    Effect of soaking time on some composition of yellow maize was investigated. Yellow maize seeds (Zea mays) were soaked in deionized water for 12, 24, 36 and 48 hours respectively followed by draining, drying and milling. The unsoaked seeds were milled and served as the control. Proximate and mineral compositions ...

  9. Phytochemical, proximate and anti-nutrient compositions of four ...

    African Journals Online (AJOL)

    Chemical constituents of plants are influenced by environmental factors and fluctuations just as many other polygenic traits. Four different green leafy vegetables commonly used in the diets of South Eastern Nigeria were analyzed with a view to determine the phytochemicals, proximate and anti-nutrient compositions of ...

  10. Studies on the proximate composition, functional properties and ...

    African Journals Online (AJOL)

    The present study produced full fat and defatted flours from matured ackee apple arils and evaluated the proximate composition and the effect of pH and salt concentrations on some of the functional properties of the full fat flour and the defatted flour. Matured ackee apple arils were oven-dried at 60 oC and milled to obtain ...

  11. Proximate and elemental composition of Bauhinia rufescens Lam ...

    African Journals Online (AJOL)

    This study is aimed at investigating the proximate contents, concentrations of some micro/macroelements and anions of the stem bark and leaves of B. rufescens with the view of validating its used as forage and medicinally by man in the treatment of diarrhoea, dysentery and in wound healing. The stem bark and leaves of ...

  12. Bridging Pedagogies: Drama, Multiliteracies, and the Zone of Proximal Development

    Science.gov (United States)

    Macy, Leonora

    2016-01-01

    This article examines how one educator embraced Vygotsky's concept of the zone of proximal development (ZPD) while using drama to scaffold learning about Dr. Seuss's "The Lorax" for first-grade students. This learning event is interpreted with reference to the ZPD and the New London Group's pedagogy of multiliteracies. The author asserts…

  13. Proximate analyses and mineral compositions of the pulp and seeds ...

    African Journals Online (AJOL)

    Proximate analyses and mineral compositions of the pulp and seeds of Adansonia digitata (Baobab fruit) ... It was concluded that the pulp of Adansonia digitata is an important source of vitamin C, while the seed is a potential source of edible oil, potassium, sodium, calcium and magnesium. Keywords: Baobab, Adansonia ...

  14. Effect Of Processing On The Proximate, Mineral, And Pasting ...

    African Journals Online (AJOL)

    Effect Of Processing On The Proximate, Mineral, And Pasting Properties Of Whole Flour Made From Some New Plantain And Banana Hybrids Pulp And Peel ... Whole plantain and banana flour may constitute an important feeding stuff for livestock, which may eventually provide protein in human diet from consumption of ...

  15. Proximate and mineral composition of six commercially important ...

    African Journals Online (AJOL)

    This study was conducted from May 2015 to April 2016 on the proximate and mineral composition of six species of fish from Obueyinomo River in Edo State, Nigeria. The six (6) species are M. electricus, C. gariepinus, T. zilli, A. monkei, P. obscura, P. africana. Biochemical assay of moisture, ash, crude protein, crude fiber, ...

  16. Rate of water absorption and proximate analysis of different varieties ...

    African Journals Online (AJOL)

    Water absorption and proximate composition of four varieties of maize; sweet corn, pop corn, white corn and yellow corn soaked at different temperatures and time duration were determined. Absorption increased with increase in temperatures and time but generally low at 45°C. The total average rate of hydration at different ...

  17. Correction of Misclassifications Using a Proximity-Based Estimation Method

    Directory of Open Access Journals (Sweden)

    Shmulevich Ilya

    2004-01-01

    Full Text Available An estimation method for correcting misclassifications in signal and image processing is presented. The method is based on the use of context-based (temporal or spatial information in a sliding-window fashion. The classes can be purely nominal, that is, an ordering of the classes is not required. The method employs nonlinear operations based on class proximities defined by a proximity matrix. Two case studies are presented. In the first, the proposed method is applied to one-dimensional signals for processing data that are obtained by a musical key-finding algorithm. In the second, the estimation method is applied to two-dimensional signals for correction of misclassifications in images. In the first case study, the proximity matrix employed by the estimation method follows directly from music perception studies, whereas in the second case study, the optimal proximity matrix is obtained with genetic algorithms as the learning rule in a training-based optimization framework. Simulation results are presented in both case studies and the degree of improvement in classification accuracy that is obtained by the proposed method is assessed statistically using Kappa analysis.

  18. The Grammaticalization of the Proximative in Tok Pisin.

    Science.gov (United States)

    Romaine, Suzanne

    1999-01-01

    Discusses grammaticalization of "laik" in Tok Pisin, meaning "want/like/desire" (from English "like") and "klostu," meaning "near" (from English "close to") as markers of proximative. Shows although "klostu" was more generally a feature of Pacific Pidgin English and began to…

  19. Phytochemical, Proximate and Mineral contents of Leaves and Back ...

    African Journals Online (AJOL)

    The phytochemical, proximate and mineral contents of Ficus capensis (leaves & bark) were analyzed, using Trease and Evans and Harboure procedure, the Association of Official Analytical Chemist (AOAC) method and Atomic Absorption Spectrophotometry and Flame Photometry respectively. This study is aimed at ...

  20. Nutritive Value Assessment of Four Crop Residues by Proximate ...

    African Journals Online (AJOL)

    Dr Grace Tona

    and well-being of the populace. There is regular supply of different kinds of animal protein sources. The keeping of sheep and goats in rural communities is an age long practice in Nigeria. The West ... the amount of methane produced as reported by Fievezet al. (2005). .... negatively to global warming. Table 2: Proximate ...

  1. Local Perception and Proximate Analysis of some Edible Forest ...

    African Journals Online (AJOL)

    Local perception and proximate analysis of some edible forest plants around the University of Agriculture Makurdi Wildlife Park were investigated. The selected plants were Anona senegalensis, Cissus populnea, Tacca leontopetaloides and Vitex doniana. The Focus Group Discussion (FGD) technique was employed to ...

  2. 75 FR 5009 - Proximity Detection Systems for Underground Mines

    Science.gov (United States)

    2010-02-01

    ..., feeders, loaders/muckers, track equipment, trucks, roof bolting machines, and mobile bridge conveyors... which you rely. Include experiences, data, models, calculations, studies and articles, and standard... outreach and/or training in the area of proximity detection (e.g., red zone warning materials). How often...

  3. Dislocation of the proximal tibiofibular joint, do not miss it

    NARCIS (Netherlands)

    van Wulfften Palthe, A.F.Y.; Musters, L.; Sonnega, R.J.A.; van der Sluijs, J.A.

    2015-01-01

    We present a case of a 45-year-old woman with a right proximal tibiofibular dislocation she sustained after a fall during roller skating. Anteroposterior and lateral radiographs confirmed the diagnosis; there were no other injuries. The dislocation was reduced by direct manipulation after

  4. Proximate and Amino Acid Composition of Celosia argentea Leaves ...

    African Journals Online (AJOL)

    The proximate, trace metals and amino acids composition of Celosia argentea were determined. The crude fat, fibre and protein contents were moderate with 1.10, 3.53 and 5.17% respectively while high in the ash content (22.43%). Results of the amino acid analysis revealed high contents of the essential amino acids with ...

  5. Proximate, phytochemical and mineral compositions of seeds of ...

    African Journals Online (AJOL)

    The envelopes were put into an oven set at 60°C for 6 h. Seeds of each plant species were milled ... This research work recommends that little quantities of these seeds should be taken periodically to minimize the adverse effects arising from consuming large quantities of the seeds. Key words: Proximate, oil, Poga oleosa, ...

  6. Performance, proximate and mineral analyses of African giant land ...

    African Journals Online (AJOL)

    Performance, proximate and mineral analyses of African giant land snail ( Archachatina marginata ) fed different nitrogen sources. ... Analysis of the Hemolymph mineral composition revealed that snails fed Diet I had the highest value for Ca2+, Mg2+ and Fe2+ while the highest value in Na+ and Zn2+ was recorded in snails ...

  7. Proximate and Anti-Nutritional Constituents of Forage Legumes at ...

    African Journals Online (AJOL)

    Five non-conventional forage legumes used as alternative plant protein sources in livestock nutrition in Nigeria were assayed for proximate and anti-nutritional compositions. The forages, Cajanus cajan, Vigna radiata, Mucuna ghana, Mucuna conchinchinensis and Mucuna rajada were harvested at emergence, 4 and 8 ...

  8. Proximate composition and functional properties of raw and ...

    African Journals Online (AJOL)

    Water binding capacity was affected in the order boiled > roasted > steeped > control. No significant change was observed for oil absorption capacity of the processed samples when compared with increase observed in water binding capacity. Key Words: Plantain, proximate composition, functional properties and ...

  9. Proximity effect in normal metal-multiband superconductor hybrid structures

    NARCIS (Netherlands)

    Brinkman, Alexander; Golubov, Alexandre Avraamovitch; Kupriyanov, M. Yu

    2004-01-01

    A theory of the proximity effect in normal metal¿multiband superconductor hybrid structures is formulated within the quasiclassical Green's function formalism. The quasiclassical boundary conditions for multiband hybrid structures are derived in the dirty limit. It is shown that the existence of

  10. local perception and proximate analysis of some edible forest plants ...

    African Journals Online (AJOL)

    User

    2. S.A. Shomkegh and. 3. Mbakwe, R. 1. Department of Forest Production and Products, University of Agriculture Makurdi, Benue State. ... Key words: Local Perception, Proximate Analysis, Edible Forest Plants, Focused Group. Discussions. INTRODUCTION ..... Deciduous Forests of India: An Explorative. Study Towards Non ...

  11. Proximate composition and sensory properties of freeze-dried ...

    African Journals Online (AJOL)

    Two Nigerian soups (Egusi soup and bitter leaf soup) were prepared and freeze - dried to produce instant soups. These instant soups and the freshly prepared portions were subjected to proximate and sensory analysis using standard methods. The results of the analysis showed that instant egusi soup contained 10.89 ...

  12. Microbiological, proximate analysis and sensory evaluation of baked ...

    African Journals Online (AJOL)

    The possibility of making bread of good nutritional, microbiological and sensory qualities from blends of wheat-breadfruit flours was examined. Blends of wheat flour (WF) with percentages of 0, 5, 10, 15, 20 and 25 of breadfruits flour (BF) were used in the production process. The proximate analysis, sensory evaluation and ...

  13. Depressionary Effect of Proximity of Residential Properties to Waste ...

    African Journals Online (AJOL)

    It is important to know if and to which extent proximity to waste disposal sites or treatment plants depresses residential property values for many reasons. Whether as a measure of the impact of the sites on health and general welfare of the resident, or to ascertain the degree of monetary depression that would be suffered by ...

  14. Proximal tibiofibular dislocation: a case report and review of literature

    NARCIS (Netherlands)

    Nieuwe Weme, R. A.; Somford, M. P.; Schepers, T.

    2014-01-01

    An isolated dislocation of the proximal tibiofibular joint is uncommon. The mechanism of this injury is usually sports related. We present a case where initial X-rays did not show the tibiofibular joint dislocation conclusively. It was diagnosed after comparative bilateral AP X-rays of the knees

  15. Unilateral proximal focal femoral deficiency, fibular aplasia, tibial ...

    African Journals Online (AJOL)

    Rabah M. Shawky

    2014-04-30

    Apr 30, 2014 ... Unilateral proximal focal femoral deficiency, fibular aplasia, tibial campomelia and oligosyndactyly in an Egyptian child – Probable. FFU syndrome. Rabah M. ... Our patient is an Egyptian male child, fifteen months old, the third in order of .... 4th and 5th metatarsal bones are absent), absent middle phalanx.

  16. Proximate Compositions and physical properties of selected maize ...

    African Journals Online (AJOL)

    Proximate compositions and physical properties of five different maize grain varieties, Oba Supa, DMR, Popcorn, local Tiv and SWAM 1 were determined in accordance with established methods. Significant differences (P≤ 0.05) were found in the moisture, ash, crude fibre, carbohydrate and fat contents among the varieties.

  17. Effect of Processing Methods on the Proximate and Energy ...

    African Journals Online (AJOL)

    Four methods of processing were assessed to investigate the effect of processing methods on the digestibility, proximate and energy composition of Lablab purpureus (Rongai) beans. The processing methods were boiling (in water), fermentation, toasting and fermentation plus toasting. Some of The beans were boiled for 0, ...

  18. Irreducible Proximal Interphalangeal Joint Dislocation of the Fourth ...

    African Journals Online (AJOL)

    Dislocation of the interphalangeal joint of the toe is a very rare injury and there are only few published reports. Most of the cases reported are those of the hallucal interphalangeal joint. There are only very few reports of complex dislocations of the proximal interphalangeal joint of the fourth toe in the world literature. Nigerian ...

  19. Worlds largest particle physics laboratory selects Proxim Wireless Mesh

    CERN Multimedia

    2007-01-01

    "Proxim Wireless has announced that the European Organization for Nuclear Research (CERN), the world's largest particle physics laboratory and the birthplace of the World Wide Web, is using it's ORiNOCO AP-4000 mesh access points to extend the range of the laboratory's Wi-Fi network and to provide continuous monitoring of the lab's calorimeters" (1/2 page)

  20. Outcome of plate osteosynthesis in the management of proximal ...

    African Journals Online (AJOL)

    Background: This paper reports the aetiology, presentation and management of proximal humeral fractures (PHF) in our setup. Objective: To ... Five of thirty two operated cases (15%) developed significant shoulder joint stiffness. ... There is need for arthroplasty in those with severe injury, particularly those with osteoporosis.

  1. Two Stages repair of proximal hypospadias: Review of 33 cases ...

    African Journals Online (AJOL)

    Materials & Methods: During the period from June 2002 to December 2009, I performed 33 cases with proximal hypospadias, at Demerdash hospital; Ain Shams University; department of paediatric surgery. Data were collected retrospectively and included patient's age at operation, degree of the hypospadias, degree of ...

  2. Reflections on the Ecolab and the Zone of Proximal Development

    Science.gov (United States)

    Luckin, Rosemary; du Boulay, Benedict

    2016-01-01

    In 1999 we reported a study that explored the way that Vygotsky's Zone of Proximal Development could be used to inform the design of an Interactive Learning Environment called the Ecolab. Two aspects of this work have subsequently been used for further research. Firstly, there is the interpretation of the ZPD and its associated theory that was…

  3. Biomechanical superiority of plate fixation for proximal tibial osteotomy.

    Science.gov (United States)

    Hartford, James M; Hester, Peter; Watt, Phil M; Hamilton, Doris; Rohmiller, Michael; Pienkowski, David

    2003-07-01

    Proximal tibial osteotomies require secure and durable fixation to allow early range of motion; however, biomechanical data comparing commonly used fixation methods are lacking. The current study was done to quantify the dynamic biomechanical performance of blade staple fixation and plate fixation of simulated proximal tibial osteotomies. A 15 degrees proximal tibial osteotomy was done on each of 18 synthetic adult composite tibias. Blade staples were used as the means of fixation in nine tibias; plate fixation was used in the remaining nine tibias. The specimens were stressed cyclically in sinusoidal loading whose peak compression and tension loads imitate those measured during normal gait. Device performance was quantified by measuring displacement at the osteotomy site and the number of cycles to failure. Plate fixation had a greater fatigue life than staples (eight plates surviving past 200,000 cycles versus one blade staple) and showed a trend toward less displacement (0.69 mm versus 0.97 mm). Plate fixation of proximal tibial osteotomies offers better fixation and dynamic mechanical performance than blade staples.

  4. Unilateral proximal focal femoral deficiency, fibular aplasia, tibial ...

    African Journals Online (AJOL)

    ... dominant mutation with possible gonadal mosaicism and with variable expression in the family, as limb anomaly in one child and cyanotic congenital heart disease in another child. Keywords: Short femur; Limb anomaly; FFU syndrome; Proximal focal femoral deficiency; Fibular aplasia; Tibial campomelia; Oligosyndactyly ...

  5. Proximity effects of high voltage electric power transmission lines on ...

    African Journals Online (AJOL)

    Yomi

    Zeki Demir. Department of Landscape Architecture, Faculty of Forestry, Düzce University. Konuralp, 81620 Düzce, Turkey. E-mail: zekidemir@duzce.edu.tr. Tel: +90-380-5421136. Fax: +90-380-5421136. Accepted 18 August, 2010. The proximity effects of high voltage electric power transmission lines on Leyland Cypress.

  6. Effect of Graded Bambara Nut Flour on Proximate Composition and ...

    African Journals Online (AJOL)

    Proximate composition and some physico-chemical properties were determined using the parameters of protein, fat, fibre, ash, moisture, carbohydrate, swelling capacity, foam capacity, foam stability, loose and packed bulk density, water absorption capacity, pH and TTA. The protein content of the samples ranged between ...

  7. Proximity Effect at Graphene - High Tc Superconductor Junctions

    Science.gov (United States)

    Wang, Da; Shih, En-Min; Arefe, Ghidewon; Kim, Youngduck; Edelberg, Drew; Andrade, Erick; Wang, Dennis; Hone, James; Dean, Cory; Pasupathy, Abhay; Department of Physics, Columbia University, New York, NY 10027, USA Collaboration

    The proximity effect is a well-known mesoscopic phenomenon where Cooper pairs from a superconductor (S) enter into a normal metal (N) that is well coupled to it. Since graphene was discovered a decade ago, the proximity effect at superconductor-graphene junctions has been extensively studied and interesting phenomena such as specular Andreev reflection and ballistic transport at graphene Josephson junctions have been observed. However, superconductors used in these experiments to date are of conventional low Tc, such as aluminum(Tc=1.2K), NbSe2(Tc=7K), and MoRe(Tc=8K). Understanding how the proximity effect works between high-Tc superconductors (pnictides and cuprates) and the Dirac Fermions of graphene remains largely unexplored. The chief technical challenge here is to create high-quality junctions between high-Tc superconductors and graphene. In this work, we will introduce a home-made setup that allows us to exfoliate, transfer and encapsulate superconductor-graphene junctions in a well controlled inert atmosphere. Transport measurements of the proximity effect at graphene-iron pnictide(FeSe, FeTeSe) and graphene-cuprate(BSCCO) junctions will be described.

  8. Effects of Planting Locations on the Proximate Compositions of ...

    African Journals Online (AJOL)

    ADOWIE PERE

    https://dx.doi.org/10.4314/jasem.v21i2.14. Keywords: locations, moringa, LGA, proximate composition, soil factors. Moringa leaves contain more vitamin A than carrots, more calcium than milk, more iron than spinach, more potassium than bananas, and more vitamin C than oranges. The leaves are considered to offer great.

  9. Proximate analysis of some dry season vegetables in Anyigba, Kogi ...

    African Journals Online (AJOL)

    STORAGESEVER

    2008-05-16

    May 16, 2008 ... the exotic vegetables cultivated in Nigeria are cabbage, lettuce, cauli-flower and turnip leafy as well as stems such as Carrot (Aliyu, 2006). ... at 550°C for 48 h, proximate chemical composition of each vegetable sample was carried out to determine the moisture, ash, fat, crude fibre, protein and carbohydrate ...

  10. Comparison of proximate and fatty acid compositions of wild brown ...

    African Journals Online (AJOL)

    The purpose of this study was to compare the fatty acid and proximate composition of two commercially exploited trout species (wild brown trout (WBT) and farmed rainbow trout (FRT)). The mean crude lipid content in FRT (4.3%) was significantly higher than that in WBT (2.7%). Total saturated fatty acid concentration ...

  11. Proximate and chemical composition of three species of snails in ...

    African Journals Online (AJOL)

    This trial was conducted to determine the proximate and chemical composition of three common species of snails in Nigeria. The species were Archachatina marginata (T1), Achatina achatina (T2), and Achatina fulica (T3). The three species constituted the three treatments and thirty-six adult snails were used for this trial ...

  12. Proximate, Physical And Sensory Properties Of Soy-Sweet Potato ...

    African Journals Online (AJOL)

    Flour mixtures consisting of full-fat soy flour and sweet potato flour at 25-75% levels were used in cookie production. Proximate, physical and sensory properties of the cookies were determined. Physical and sensory properties investigated included thickness, diameter, spread factor, spread ratio, fragility, appearance, ...

  13. Proximate and Cholesterol Composition of Selected Fast Foods ...

    African Journals Online (AJOL)

    Fast foods consumption has been on the increase in Nigeria raising concerns about the nutritional and health implications. This study was carried out to determine the proximate composition and cholesterol contents of four commonly consumed fast foods (doughnut, chicken pie, roasted chicken, and Jollof rice) sold in ...

  14. Proximate composition and basic phytochemical assessment of two ...

    African Journals Online (AJOL)

    Administrator

    The nut of the yellow variety had terpenoids and steroids present in it while the nut of the red variety had alkaloids present. Statistical analyses carried out showed that there were no significant differences (p≤0.05) between the two varieties based on their proximate composition. INTRODUCTION. Terminalia catappa is ...

  15. Fertility decline in Malawi: An analysis of the proximate determinants ...

    African Journals Online (AJOL)

    The paper examines trends in the proximate determinants of fertility (nuptiality or marriage, contraception and post-partum infecundability) in Malawi during the twelve-year period 1992-2004, with a view to explaining the factors responsible for fertility decline in the country. The study uses the Malawi Demographic and ...

  16. Levels and proximate determinants of fertility in Butajira District ...

    African Journals Online (AJOL)

    The impediment of early marriage was revised in the national family code which claims assessment of fertility situations. Objectives: This study aimed at measuring levels and fertility inhibition effects of proximate determinants in Butajira district. Methods: A cross-sectional study was conducted on resident women of ...

  17. Proximity effect of electron beam lithography on single-electron ...

    Indian Academy of Sciences (India)

    monly used technique in this field, and many researchers have been investigating its application to make nanopatterns. In electron beam lithography, the well-known proximity effect refers to .... electrodes are grounded. The charging effect, which blocks the injection/ejection of a single charge into/from a quantum dot, ...

  18. Proximate and Vitamin Content of Four Nigerian Pterocarpus Species

    African Journals Online (AJOL)

    Determination of the proximate and vitamin contents of four Nigerian Pterocarpus species; Pterocarpus osun, P. soyauxii, P. santalinoides and P. mildbraedii was carried out. Freshly expanded and mature leaves of the plants were used for the analysis. The investigation revealed that on the average the plants contained ...

  19. Proximity focusing RICH detector based on multilayer silica aerogel radiator

    CERN Document Server

    De Leo, R; Bellunato, T; Calvi, M; Cisbani, E; Cusanno, F; Garibaldi, F; Lagamba, L; Marra, M; Marrone, S; Matteuzzi, C; Musico, P; Nappi, E; Perego, D L; Torrioli, S; Vilardi, I

    2010-01-01

    The performance of a proximity focusing Ring Imaging Cherenkov detector equipped with a radiator of silica aerogel is presented. The aerogel tile used is a monolith with variable index of refraction. Cherenkov photons are detected with high granularity by eight Hamamatsu H9500 flat panel multi anode phototubes.

  20. Proximate, Vitamins and Mineral Composition of Vitex doniana ...

    African Journals Online (AJOL)

    Keywords: Vitex doniana, micronutrients, proximate, vitamins and mineral composition, Fruit. ... Vitamin B2 and Spectrophotometric method for. Vitamin B6, while titremetric method was used for Vitamin C. Mineral content: Mineral analysis was carried out after sample .... to calcium for bone, teeth and muscles growth.

  1. Effect of drought/irrigation on proximate composition and ...

    African Journals Online (AJOL)

    Enset [Ensete ventricosum (Welw.) Cheesman] is an important root crop serving as a carbohydrate rich food source in Ethiopia. Perennial crops, like enset, are often exposed to recurrent dry periods which could greatly affect their growth, physiology and yield. The effect of induced drought/irrigation on the proximate ...

  2. Heavy metal and proximate composition associated with the ...

    African Journals Online (AJOL)

    Changes in the heavy metal content and proximate composition during the 28 day composting of cassava peels used in the cultivation of the oyster mushrooms Pleurotus ostreatus strain EM-1 was studied. Significant dry weight variations of cellulose, hemicellulose and fat contents were observed from day 0 to 12.

  3. Proximate and mineral analysis of some wild edible mushrooms ...

    African Journals Online (AJOL)

    Proximate and mineral analysis of five species of mushroom, Lentinus squarrosulus, Volvariella volvacea, Coprinus micaceus, Lepiota procera, and Auricularia auricula were examined in this study to determine their nutritional value. These mushrooms were found to contain on the average, 3.24 to 8.70% of crude fibre; 4.12 ...

  4. Proximal femoral periprosthetic fracture fixation with a hooked ...

    African Journals Online (AJOL)

    Proximal femoral periprosthetic fracture fixation with a hooked locking plate: a Kenyan experience. ... The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader). If you would like more information about how to print, save, and ...

  5. Proximate, mineral and vitamin C composition of vegetable Gbolo ...

    African Journals Online (AJOL)

    Gbolo (Crassocephalum crepidioides and Crassocephalum rubens) is a traditional leafy vegetable highly consumed in southern and central Benin, as well as in some part of northern Benin. The nutritional potential of the two species of Gbolo were evaluated through their proximate composition, mineral and vitamin C ...

  6. Effect of drying temperatures on the proximate composition and ...

    African Journals Online (AJOL)

    A study was conducted to dry chicken eggs in order to determine the effect of drying temperatures on the proximate composition and sensory attributes of dried eggs. The albumen, yolk and whole egg were dried separately at temperatures of 50, 55 and 60oC. The drying time for the samples ranged from 7hrs20mins to ...

  7. Long‑Term Outcome of Endoprosthetic Replacement for Proximal ...

    African Journals Online (AJOL)

    Giant cell tumor (GCT) represents 5% of neoplasms of bone. It is a benign locally aggressive tumor usually involving the distal end of the femur, proximal tibia and distal radius in young adults.[1-3] The main variables to be considered for planning treatment include the site of involvement and Campanacci stage of the tumor.

  8. Children's Attentional Processing of Mother and Proximity Seeking.

    Directory of Open Access Journals (Sweden)

    Guy Bosmans

    Full Text Available Attachment expectations regarding the availability of mother as a source for support are supposed to influence distressed children's support seeking behavior. Because research is needed to better understand the mechanisms related to support seeking behavior, this study tested the hypothesis that the cognitive processing of mother-related information is linked to proximity and support seeking behavior. Uncertainty in maternal support has been shown to be characterized by a biased attentional encoding of mother, reducing the breadth of children's attentional field around her. We investigated whether this attentional bias is related to how long distressed children wait before seeking their mother's proximity. Thirty-three children (9-11 years participated in this study that consisted of experimental tasks to measure attentional breadth and to observe proximity seeking behavior and of questionnaires to measure confidence in maternal support and experienced distress. Results suggested that distressed children with a more narrow attentional field around their mother wait longer to seek her proximity. Key Message: These findings provide a first support for the hypothesis that the attentional processing of mother is related to children's attachment behavior.

  9. Effect of thermal processing methods on the proximate composition ...

    African Journals Online (AJOL)

    The nutritive value of raw and thermal processed castor oil seed (Ricinus communis) was investigated using the following parameters; proximate composition, gross energy, mineral constituents and ricin content. Three thermal processing methods; toasting, boiling and soaking-and-boiling were used in the processing of the ...

  10. Proximity effects of high voltage electric power transmission lines on ...

    African Journals Online (AJOL)

    The proximity effects of high voltage electric power transmission lines on Leyland Cypress (xCupressocyparis leylandii (Dallim. and A.B. Jacks.) Dallim) and Japanese Privet (Ligustrum japonicum Thunb.) growth were examined in a private nursery located in Sakarya, Turkey. Five transect were randomly chosen in both ...

  11. 37 Nigerian Journal of Chemical Research Vol. 19, 2014 Proximate ...

    African Journals Online (AJOL)

    AL-AMAANI

    Nigerian Journal of Chemical Research. Vol. 19, 2014. Proximate, Mineral and Anti-nutritional Composition of Cucurbita Maxima Fruits Parts. Mohaammed S. S. 1 ., Paiko Y. B. 2 ., Mann A. 2 ., Ndamitso M. M. 3 ., Mathew J. T. 2 . and Maaji, S. 1 . 1. Deparment of Biochemistry, Federal University of Technology, P.M. B. 65, ...

  12. Observing Complex Systems Thinking in the Zone of Proximal Development

    Science.gov (United States)

    Danish, Joshua; Saleh, Asmalina; Andrade, Alejandro; Bryan, Branden

    2017-01-01

    Our paper builds on the construct of the zone of proximal development (ZPD) (Vygotsky in Mind in society: the development of higher psychological processes, Harvard University Press, Cambridge, 1978) to analyze the relationship between students' answers and the help they receive as they construct them. We report on a secondary analysis of…

  13. Visualizing cellular interactions with a generalized proximity reporter.

    Science.gov (United States)

    Sellmyer, Mark A; Bronsart, Laura; Imoto, Hiroshi; Contag, Christopher H; Wandless, Thomas J; Prescher, Jennifer A

    2013-05-21

    Interactions among neighboring cells underpin many physiological processes ranging from early development to immune responses. When these interactions do not function properly, numerous pathologies, including infection and cancer, can result. Molecular imaging technologies, especially optical imaging, are uniquely suited to illuminate complex cellular interactions within the context of living tissues in the body. However, no tools yet exist that allow the detection of microscopic events, such as two cells coming into close proximity, on a global, whole-animal scale. We report here a broadly applicable, longitudinal strategy for probing interactions among cells in living subjects. This approach relies on the generation of bioluminescent light when two distinct cell populations come into close proximity, with the intensity of the optical signal correlating with relative cellular location. We demonstrate the ability of this reporter strategy to gauge cell-cell proximity in culture models in vitro and then evaluate this approach for imaging tumor-immune cell interactions using a murine breast cancer model. In these studies, our imaging strategy enabled the facile visualization of features that are otherwise difficult to observe with conventional imaging techniques, including detection of micrometastatic lesions and potential sites of tumor immunosurveillance. This proximity reporter will facilitate probing of numerous types of cell-cell interactions and will stimulate the development of similar techniques to detect rare events and pathological processes in live animals.

  14. Proximate composition and the functional properties of defatted ...

    African Journals Online (AJOL)

    The proximate composition of the Kargo seeds and the physico-chemical properties of the seed oil have been determined. Matured dried seeds were collected. They were then dehusked and pulverized into a fine powder and kept in air tight sample bottle for further analysis. Functional properties of the defatted sample and ...

  15. Proximate and nutrient analysis of selected vegetable species: A ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-06-17

    Jun 17, 2009 ... ascorbic acid and palpable concentration of trace minerals (Prakash and Pal, ... vegetables plays a crucial role in assessing their nutri- tional significance .... Table 4. Correlation matrix of the various parameters studied for the proximate analysis of selected plant species. Moisture. (wet). Moistures. (dry). Ash.

  16. Determination of Proximate Composition and Amino Acid Profile of ...

    African Journals Online (AJOL)

    Johnny

    livestock nutrition. Keywords: Sesamum indicum; Proximate composition; Amino acid profile; Nutrient value. Correspondence: ubi.benjamin@yahoo.com. Introduction. Sesame ... presence of oxygen in the air to CO2 at a temperature of 600 0C (dry ashing). The % ash content was ..... Effect of Heat Treatment and Defatting.

  17. Proximity to coast is linked to climate change belief.

    Directory of Open Access Journals (Sweden)

    Taciano L Milfont

    Full Text Available Psychologists have examined the many psychological barriers to both climate change belief and concern. One barrier is the belief that climate change is too uncertain, and likely to happen in distant places and times, to people unlike oneself. Related to this perceived psychological distance of climate change, studies have shown that direct experience of the effects of climate change increases climate change concern. The present study examined the relationship between physical proximity to the coastline and climate change belief, as proximity may be related to experiencing or anticipating the effects of climate change such as sea-level rise. We show, in a national probability sample of 5,815 New Zealanders, that people living in closer proximity to the shoreline expressed greater belief that climate change is real and greater support for government regulation of carbon emissions. This proximity effect held when adjusting for height above sea level and regional poverty. The model also included individual differences in respondents' sex, age, education, political orientation, and wealth. The results indicate that physical place plays a role in the psychological acceptance of climate change, perhaps because the effects of climate change become more concrete and local.

  18. Some Proximate Analysis of African Pear ( Dacryodes Edulis ...

    African Journals Online (AJOL)

    0.05) were observed between the samples for all the parameters measured. Fruit density showed a negative correlation (r = -0.86) with the pulp/seed ratio. Significant differences were also observed in the proximate composition of the African pear pulp. The major components of the pulp were moisture (36.5% to 53.82%), ...

  19. Proximate composition and mineral content in different, types of ...

    African Journals Online (AJOL)

    Proximate composition and mineral content in different, types of traditional TOGWA used in Tanzania as a weaning food. ... Crude fibre was also higher in traditional and simulated togwa than in the main ingredients, while carbohydrate percent of DM and energy contents were lower than in the ingredients. Ash contents in ...

  20. Proximate analysis of selected sorghum cultivars | Jimoh | Bayero ...

    African Journals Online (AJOL)

    The proximate analysis revealed that sorghum samples contains appreciable nutrient contents. Also from the result, it has shown that the values of the improved varieties from the Institute for Agricultural research (IAR) Zaria is higher in the parameters analysed as compared to the local samples. The mineral composition of ...

  1. Extraoral imaging for proximal caries detection: Bitewings vs scanogram.

    Science.gov (United States)

    Khan, Emad A; Tyndall, Donald A; Caplan, Daniel

    2004-12-01

    The objective of this study was to compare the diagnostic accuracy of 3 extraoral imaging modalities with an intraoral bitewing radiograph for proximal caries detection. Three modalities of Cranex TOME scanograms, x-ray film and DenOptix photostimulable phosphor plates with and without digital enhancement, were compared with Insight intraoral radiographs for proximal caries detection. Nine observers evaluated images of the proximal surfaces of 45 extracted posterior teeth. The presence or absence of caries was scored using a 5-point confidence scale. The ground truth was determined from histological sections. Responses were evaluated by repeated measures analysis of variance (ANOVA) for areas under receiver operating characteristic (ROC) curves (A z ). Repeated measures ANOVA (at alpha = 0.05) demonstrated significant differences among modalities ( P = .041). Paired t tests with Bonferroni correction demonstrated that Insight was superior to only unenhanced digital scanograms ( P = .003). Mean A z scores (+/-SD) were 0.73 (+/-0.08) for Insight, 0.65 (+/-0.06) for screen/film scanogram, 0.64 (+/-0.04) for unenhanced digital scanogram, and 0.66 (+/-0.07) for enhanced digital scanogram. The performances of film-based and enhanced digital scanograms were not statistically different from Insight film for proximal caries detection. Unenhanced digital scanograms exhibited a statistically significant lower diagnostic accuracy than Insight film.

  2. Sharpening a Tool for Teaching: The Zone of Proximal Development

    Science.gov (United States)

    Wass, Rob; Golding, Clinton

    2014-01-01

    Vygotsky's Zone of Proximal Development (ZPD) provides an important understanding of learning, but its implications for teachers are often unclear or limited and could be further explored. We use conceptual analysis to sharpen the ZPD as a teaching tool, illustrated with examples from teaching critical thinking in zoology. Our conclusions are…

  3. Scaffolding Critical Thinking in the Zone of Proximal Development

    Science.gov (United States)

    Wass, Rob; Harland, Tony; Mercer, Alison

    2011-01-01

    This paper explores student experiences of learning to think critically. Twenty-six zoology undergraduates took part in the study for three years of their degree at the University of Otago, New Zealand. Vygotsky's developmental model of the Zone of Proximal Development (ZPD) provided a framework as we examined how critical thinking was developed.…

  4. Effect of Different Soaking Time and Boiling on the Proximate ...

    African Journals Online (AJOL)

    The effect of soaking time on the proximate composition and functional properties of sprouted sesame seed flour were investigated. Sesame seed samples were cleaned and pretreated by soaking in clean water for 8, 10, 12, 14 and 16 h. One batch was sprouted for 36 h and another portion was sprouted and then boiled ...

  5. Proximal dup(10q): Case report and literature review

    Energy Technology Data Exchange (ETDEWEB)

    Barritt, J.A.; Teague, K.E.; Bodurtha, J.N. [Virginia Commonwealth Univ., Richmond, VA (United States)] [and others

    1994-09-01

    We report a case of a proximal dir dup(10q) in a female with multiple congenital anomalies. During infancy she was noted to gave growth retardation, microcephaly, microphthalmia, coloboma, a long, beaked nose, posteriorly rotated ears with simple helices, full bowed lips, widely-spaced nipples, broad first toes, hypermobile and proximally placed thumbs, a heart murmur, PDA, and coarctation of the aorta. Additional findings at age 13 included a full columella, short philtrum, thin limbs, bilateral blindness, and mental retardation, as well as continued growth retardation. Her medical history included precocious puberty at age 8 and a diagnosis of hyperactivity. Using FISH with multiple probes combined with GTG-banding, the aberrant chromosome was determined to be a dir dup(10)(q21{r_arrow}q22). Parental chromosomes were normal and the family history was unremarkable. The parental origin of the dir dup(10) is being assessed using DNA markers. Five similar cases of proximal dup(10q) have been reported previously. Consistent characteristics include low birth weight, developmental and psychomotor delay, growth retardation, and microcephaly. Also found in most cases were short prominent philtrum, bowed mouth, PDA, thin limbs, coloboma, micropthalmia, deep set eyes, and other ocular anomalies. Our case is unique in that she has a long, beaked nose, precocious puberty, and hyperactivity. Future studies such as this, using molecular cytogenetic techniques to better define the chromatin involved in proximal dup(10q), may lead to its recognition as a distinct clinical phenotype.

  6. A STUDY ON PROXIMAL HUMERAL FRACTURES STABILISED WITH PHILOS PLATE

    Directory of Open Access Journals (Sweden)

    Praveen Sivakumar K

    2017-02-01

    Full Text Available BACKGROUND Techniques for treating complex proximal humeral fractures vary and include fixations using tension bands, percutaneous pins, bone suture, T-plates, intramedullary nails, double tubular plates, hemiarthroplasty, plant tan humerus fixator plates, Polaris nails and blade plates. Complications of these techniques include cutout or back out of the screws and plates, avascular necrosis, nonunion, malunion, nail migration, rotator cuff impairment and impingement syndromes. Insufficient anchorage from conventional implants may lead to early loosening and failure, especially in osteoporotic bones. In general, nonoperative treatment of displaced three and four-part fractures of the proximal humerus leads to poor outcome due to intraarticular nature of injury and inherent instability of the fragments. Comminuted fractures of the proximal humerus are at risk of fixation failure, screw loosening and fracture displacement. Open reduction and internal fixation with conventional plate and screws has been associated with unacceptably high incidence of screw pull out. PHILOS (the proximal humeral internal locking system plate is an internal fixation system that enables angled stabilisation with multiple interlocking screws for fractures of the proximal humerus. MATERIALS AND METHODS 30 patients with proximal humerus fractures who were admitted in the Department of Orthopaedics, Government General Hospital, Kakinada, during the period November 2014 - November 2016 were taken up for study according to inclusion criteria. All patients were treated with PHILOS plate. These proximal humerus fractures were classified according to Neer’s classification. Patients were followed up at 6 weeks, 12 weeks and 6 months’ interval. Functional outcomes for pain, range of motion and muscle power and function were assessed using the Constant-Murley scoring system. Collected data analysed with independent t-test and ANNOVA test. RESULTS The outcome of the study was 1

  7. Surgical treatment of proximal humerus fractures using PHILOS plate

    Directory of Open Access Journals (Sweden)

    Vijay Sharma

    2014-10-01

    Full Text Available 【Abstract】Objective: To evaluate functional outcome and complications of open reduction and internal fixation with proximal humeral internal locking system (PHILOS plate for proximal humerus fractures. Methods: We reviewed 51 patients who underwent open reduction and internal fixation with PHILOS plate between the years 2007 to 2012. There were 35 men and 16 women with a mean age of 38 years (range 24-68. There were 41 patients in the age group of <60 years and 10 patients in the age group of >60 years. According to Neer classification system, 8, 15 and 23 patients had 2-part, 3-part, and 4-part fractures, respectively and 5 patients had 4-part fracture dislocation. All surgeries were carried out at our tertiary care trauma centre. Functional evaluation of the shoulder at final follow-up was done using Constant-Murley score. Results: The mean follow-up period was 30 months (range 12-44 months. Two patients were lost to followup. Of the remaining 49 patients, all fractures were united clinically and radiologically. The mean time for radiological union was 12 weeks (range 8-20 weeks. At the final follow-up the mean Constant-Murley score was 79 (range 50-100. The results were excellent in 25 patients, good in 13 patients, fair in 6 atients and poor in 5 patients. During the follow-up, four cases of varus malunion, one case of subacromial impingement, one case of deep infection, one case of intraarticular screw penetration and one case of failure of fi xation were noted. No cases of avascular necrosis, hardware failure, locking screw loosening or nonunion were noted. Conclusion: PHILOS provides stable fixation in proximal humerus fractures. To prevent potential complications like avascular necrosis, meticulous surgical dissection to preserve vascularity of humeral head is necessary. Key words: Proximal humerus fracture; Fracture fixation, internal; Proximal humeral internal locking system

  8. Proximal supination osteotomy of the first metatarsal for hallux valgus.

    Science.gov (United States)

    Yasuda, Toshito; Okuda, Ryuzo; Jotoku, Tsuyoshi; Shima, Hiroaki; Hida, Takashi; Neo, Masashi

    2015-06-01

    Risk factors for hallux valgus recurrence include postoperative round-shaped lateral edge of the first metatarsal head and postoperative incomplete reduction of the sesamoids. To prevent the occurrence of such conditions, we developed a proximal supination osteotomy of the first metatarsal. Our aim was to describe this novel technique and report the outcomes in this report. Sixty-six patients (83 feet) underwent a distal soft tissue procedure combined with a proximal supination osteotomy. After the proximal crescentic osteotomy, the proximal fragment was pushed medially, and the distal fragment was abducted, and then the distal fragment of the first metatarsal was manually supinated. Outcomes were assessed using the American Orthopaedic Foot & Ankle Society (AOFAS) score and radiographic examinations. The average follow-up duration was 34 (range, 25 to 52) months. The mean AOFAS score improved significantly from 58.0 points preoperatively to 93.8 points postoperatively (P hallux valgus and intermetatarsal angle decreased significantly from 38.6 and 18.0 degrees preoperatively to 11.0 and 7.9 degrees postoperatively, respectively (both, P hallux valgus, defined as a hallux valgus angle ≥ 25 degrees. The rates of occurrence of a positive round sign and incomplete reduction of the sesamoids significantly decreased postoperatively, which may have contributed to the low hallux valgus recurrence rates. We conclude that a proximal supination osteotomy was an effective procedure for correction of hallux valgus and can achieve a low rate of hallux valgus recurrence. Level IV, retrospective case series. © The Author(s) 2015.

  9. Open reduction and internal fixation of proximal humeral fractures with use of the locking proximal humerus plate. Surgical technique.

    Science.gov (United States)

    Konrad, G; Bayer, J; Hepp, P; Voigt, C; Oestern, H; Kääb, M; Luo, C; Plecko, M; Wendt, K; Köstler, W; Südkamp, N

    2010-03-01

    The treatment of unstable displaced proximal humeral fractures, especially in the elderly, remains controversial. The objective of the present prospective, multicenter, observational study was to evaluate the functional outcome and the complication rate after open reduction and internal fixation of proximal humeral fractures with use of a locking proximal humeral plate. One hundred and eighty-seven patients (mean age, 62.9 +/- 15.7 years) with an acute proximal humeral fracture were managed with open reduction and internal fixation with a locking proximal humeral plate. At the three-month, six month,and one-year follow-up examinations, 165 (88%), 158 (84%), and 155 (83%) of the 187 patients were assessed with regard to pain, shoulder mobility, and strength. The Constant score was determined at each interval, and the Disabilities of the Arm, Shoulder and Hand (DASH) score was determined for the injured and contralateral extremities at the time of the one-year follow-up. Between three months and one year, the mean range of motion and the mean Constant score for the injured shoulders improved substantially. Twelve months after surgery, the mean Constant score for the injured side was 70.6 +/- 13.7 points, corresponding to 85.1% +/- 14.0% of the score for the contralateral side. The mean DASH score at the time of the one-year follow-up was 15.2 +/- 16.8 points. Sixty-two complications were encountered in fifty-two (34%) of 155 patients at the time of the one-year follow-up. Twenty-five complications (40%) were related to incorrect surgical technique and were present at the end of the operative procedure. The most common complication, noted in twenty-one (14%) of 155 patients, was intraoperative screw perforation of the humeral head. Twenty-nine patients (19%) had an unplanned second operation within twelve months after the fracture. Surgical treatment of displaced proximal humeral fractures with use of the locking proximal humeral plate that was evaluated in the

  10. Radiographic and Computed Tomographic Configuration of Incomplete Proximal Fractures of the Proximal Phalanx in Horses Not Used for Racing.

    Science.gov (United States)

    Brünisholz, Hervé P; Hagen, Regine; Fürst, Anton E; Kuemmerle, Jan M

    2015-10-01

    To characterize the configuration of incomplete proximal fractures of the proximal phalanx (P1) in horses not used for racing and compare radiographic with computed tomography (CT) findings. Historical cohort. Twenty-four horses with incomplete fractures of P1. Medical records of horses not used for racing diagnosed with an incomplete proximal fracture of P1 based on clinical and radiographic examination and confirmed by CT between 2008 and 2013 were retrieved. Radiographs and CT studies of these horses were analyzed using a subjective grading system and by measuring variables that characterized fracture configuration. Twenty-four horses were included (20 Warmbloods) with a mean age of 9.5 years and mean body weight of 574 kg. Fourteen forelimbs and 10 hind limbs were affected. Mean duration of lameness was 8.7 weeks. Computed tomography was superior to radiography in both identifying the fracture and determining fracture size and location. On CT, 92% of fractures were located in the mid-sagittal plane. Mean proximodistal length of the fracture was 13 mm. Fractures were frequently not bicortical. Fractures in forelimbs were located significantly more dorsally than fractures in hind limbs. A distinct fracture pattern with 2 subchondral lines running parallel in close proximity to each other was identified in 54% of cases. Incomplete proximal fractures of P1 have significant variation in their configurations, especially their dorsopalmar/-plantar location. Computed tomography examination allowed clear identification of the fracture configurations and was superior to radiography. © Copyright 2015 by The American College of Veterinary Surgeons.

  11. Extrapolating demography with climate, proximity and phylogeny: approach with caution.

    Science.gov (United States)

    Coutts, Shaun R; Salguero-Gómez, Roberto; Csergő, Anna M; Buckley, Yvonne M

    2016-12-01

    Plant population responses are key to understanding the effects of threats such as climate change and invasions. However, we lack demographic data for most species, and the data we have are often geographically aggregated. We determined to what extent existing data can be extrapolated to predict population performance across larger sets of species and spatial areas. We used 550 matrix models, across 210 species, sourced from the COMPADRE Plant Matrix Database, to model how climate, geographic proximity and phylogeny predicted population performance. Models including only geographic proximity and phylogeny explained 5-40% of the variation in four key metrics of population performance. However, there was poor extrapolation between species and extrapolation was limited to geographic scales smaller than those at which landscape scale threats typically occur. Thus, demographic information should only be extrapolated with caution. Capturing demography at scales relevant to landscape level threats will require more geographically extensive sampling. © 2016 John Wiley & Sons Ltd/CNRS.

  12. Proximal Limb Weakness Reverting After CSF Diversion In Intracranial Hypertension

    Directory of Open Access Journals (Sweden)

    Sinha S

    2005-01-01

    Full Text Available We report about two young girls who developed progressive visual failure secondary to increased intracranial pressure and had significant proximal muscle weakness of limbs. Patients with elevated intracranial pressure (ICP may present with "false localizing signs", besides having headache, vomiting and papilledema. Radicular pain as a manifestation of raised ICP is rare and motor weakness attributable to polyradiculopathy is exceptional. Two patients with increased intracranial pressure without lateralizing signs′ had singnificant muscle weakness. Clinical evaluation and laboratory tests did not disclose any other cause for weakness. Following theco-peritoneal shunt, in both patients, there was variable recovery of vision but the proximal weakness and symptoms of elevated ICP improved rapidly. Recognition of this uncommon manifestation of raised ICP may obviate the need for unnecessary investigation and reduce morbidity due to weakness by CSF diversion procedure.

  13. STRaND-2: Visual inspection, proximity operations & nanosatellite docking

    Science.gov (United States)

    Bridges, C. P.; Taylor, B.; Horri, N.; Underwood, C. I.; Kenyon, S.; Barrera-Ars, J.; Pryce, L.; Bird, R.

    The Surrey Training Research and Nanosatellite Demonstrator (STRaND) programme has been success in identifying and creating a leading low-cost nanosatellite programme with advanced attitude and orbit control system (AOCS) and experimental computing platforms based on smart-phone technologies. The next demonstration capabilities, that provide a challenging mission to the existing STRaND platform, is to perform visual inspection, proximity operations and nanosatellite docking. Visual inspection is to be performed using a COTS LIDAR system to estimate range and pose under 100 m. Proximity operations are controlled using a comprehensive guidance, navigation and control (GNC) loop in a polar form of the Hills Clohessy Wiltshire (HCW) frame including J2 perturbations. And finally, nanosatellite docking is performed at under 30 cm using a series of tuned magnetic coils. This paper will document the initial experiments and calculations used to qualify LIDAR components, size the mission thrust and tank requirements, and air cushion table demonstrations of the docking mechanism.

  14. Proximate composition analysis posterior to the cryopreservation of Chaetoceros calcitrans

    Directory of Open Access Journals (Sweden)

    Joan Salas-Leiva

    2015-12-01

    Full Text Available Objective. The effect of cryopreservation on the proximate composition of microalgae Chaetoceros calcitrans was evaluated. Materials and methods. C. calcitrans was cultured and cryopreserved using 5% (v/v dimethylsulfoxide as cryoprotectant. The freezing was controlled at a rate of 3°C/min, up to -60°C and then the microalgae were immersed in liquid nitrogen (-196°C. After storage in liquid nitrogen, microalgae were rapidly thawed out and subcultured. The percentage of proteins, lipids and carbohydrates was analyzed using absorption spectrophotometry and the organic matter was studied by gravimetric analysis. Results. There was no significant variation between the proximate composition of C. calcitrans cryopreserved and the controls (p>0.05. Conclusion. Our results show that, despite low cell recovery after the preservation of this organism at low temperatures, there is no apparent loss of nutritional characteristics caused by the storing process at low temperatures.

  15. Impact of Relational Proximity on Distress from Infidelity

    Directory of Open Access Journals (Sweden)

    Maryanne Fisher

    2009-10-01

    Full Text Available Men are generally more distressed by a partner's sexual infidelity whereas women are generally more distressed by a partner's emotional infidelity. The importance of the identity of the interloper, however, has been neglected. We explored the influence of relational proximity (i.e., the degree of genetic relatedness on distress about infidelity. In Study 1, participants were most distressed when the imagined infidelity occurred between their current mate and close kin. In Study 2, relational proximity mattered more than the type of sexual behavior, the likelihood of contracting a sexually transmitted disease, and the likelihood of the infidelity leading to a damaged reputation. Together, the results indicate that identity matters, especially if the interloper is someone with whom we have familial bonds.

  16. Automated space vehicle control for rendezvous proximity operations

    Science.gov (United States)

    Lea, Robert N.

    1988-01-01

    Rendezvous during the unmanned space exploration missions, such as a Mars Rover/Sample Return will require a completely automatic system from liftoff to docking. A conceptual design of an automated rendezvous, proximity operations, and docking system is being implemented and validated at the Johnson Space Center (JSC). The emphasis is on the progress of the development and testing of a prototype system for control of the rendezvous vehicle during proximity operations that is currently being developed at JSC. Fuzzy sets are used to model the human capability of common sense reasoning in decision making tasks and such models are integrated with the expert systems and engineering control system technology to create a system that performs comparably to a manned system.

  17. Proximal hamstring lengthening in the sitting cerebral palsy patient.

    Science.gov (United States)

    Elmer, E B; Wenger, D R; Mubarak, S J; Sutherland, D H

    1992-01-01

    We retrospectively studied 62 nonambulatory children with spastic quadriplegic cerebral palsy who underwent proximal hamstring lengthening to improve hip and spine positioning. Preoperatively, all had hamstring contracture, with difficulty sitting due to hip extensor thrust and increased kyphosis. Thirty-five patients with follow-up greater than or equal to 2 years were studied using a modified Reimer scale to assess sitting ability. Sitting ability improved significantly (p less than 0.01) postoperatively, along with popliteal angle (p less than 0.001) and straight leg raising (p less than 0.001). Proximal hamstring lengthening is effective in treating severe hamstring contractures in the wheelchair-bound child with cerebral palsy.

  18. Affordable dual-sensing proximity sensor for touchless interactive systems

    KAUST Repository

    Nassar, Joanna M.

    2016-09-13

    We report an ultra-low cost flexible proximity sensor using only off-the-shelf recyclable materials such as aluminum foil, napkin and double-sided tape. Unlike previous reports, our device structure exhibits two sensing capabilities in one platform, with outstanding long detection range of 20 cm and pressure sensitivity of 0.05 kPa. This is the first ever demonstration of a low-cost, accessible, and batch manufacturing process for pressure and proximity sensing on a singular platform. The mechanical flexibility of the sensor makes it possible to mount on various irregular platforms, which is vital in many areas, such as robotics, machine automation, vehicular technology and inspection tools.

  19. Alternating proximal gradient method for nonnegative matrix factorization

    CERN Document Server

    Xu, Yangyang

    2011-01-01

    Nonnegative matrix factorization has been widely applied in face recognition, text mining, as well as spectral analysis. This paper proposes an alternating proximal gradient method for solving this problem. With a uniformly positive lower bound assumption on the iterates, any limit point can be proved to satisfy the first-order optimality conditions. A Nesterov-type extrapolation technique is then applied to accelerate the algorithm. Though this technique is at first used for convex program, it turns out to work very well for the non-convex nonnegative matrix factorization problem. Extensive numerical experiments illustrate the efficiency of the alternating proximal gradient method and the accleration technique. Especially for real data tests, the accelerated method reveals high superiority to state-of-the-art algorithms in speed with comparable solution qualities.

  20. Longitudinal Proximity Effects in Superconducting Transition-Edge Sensors

    Energy Technology Data Exchange (ETDEWEB)

    Sadleir, John E.; Smith, Stephen J.; Bandler, Simon R.; Chervenak, James A.; Clem, John R.

    2010-01-29

    We have found experimentally that the critical current of a square thin-film superconducting transition-edge sensor (TES) depends exponentially upon the side length L and the square root of the temperature T, a behavior that has a natural theoretical explanation in terms of longitudinal proximity effects if the TES is regarded as a weak link between superconducting leads. As a consequence, the effective transition temperature T{sub c} of the TES is current dependent and at fixed current scales as 1/L{sup 2}. We have also found that the critical current can show clear Fraunhofer-like oscillations in an applied magnetic field, similar to those found in Josephson junctions. We have observed the longitudinal proximity effect in these devices over extraordinarily long lengths up to 290 {micro}m, 1450 times the mean-free path.

  1. Indications for computed tomography (CT-) diagnostics in proximal humeral fractures

    DEFF Research Database (Denmark)

    Bahrs, Christian; Rolauffs, Bernd; Südkamp, Norbert P

    2009-01-01

    diagnostics depending on the fractured parts. METHODS: In a prospective diagnostic study in two level 1 trauma centers, 44 patients with proximal humeral fractures were diagnosed with conventional X-rays (22 AP + axillary views, 22 AP + scapular Y-views) and CT (multi-planar reconstruction (MPR) and maximum...... a significantly better assessment of the relevant structures than conventional diagnostics (p X-rays with AP view and a high-quality axillary view are useful for primary diagnostics of the fracture......--independently of the number of fractured parts--when the proximal humerus and the shoulder joint are not presented with sufficient X-ray-quality to establish a treatment plan....

  2. Copper in silicon: Quantitative analysis of internal and proximity gettering

    Energy Technology Data Exchange (ETDEWEB)

    McHugo, S.A. [Lawrence Berkeley National Lab., CA (United States); Flink, C.; Weber, E.R. [Univ. of California, Berkeley, CA (United States)] [and others

    1997-08-01

    The behavior of copper in the presence of a proximity gettering mechanism and a standard internal gettering mechanism in silicon was studied. He implantation-induced cavities in the near surface region were used as a proximity gettering mechanism and oxygen precipitates in the bulk of the material provided internal gettering sites. Moderate levels of copper contamination were introduced by ion implantation such that the copper was not supersaturated during the anneals, thus providing realistic copper contamination/gettering conditions. Copper concentrations at cavities and internal gettering sites were quantitatively measured after the annealings. In this manner, the gettering effectiveness of cavities was measured when in direct competition with internal gettering sites. The cavities were found to be the dominant gettering mechanism with only a small amount of copper gettered at the internal gettering sites. These results reveal the benefits of a segregation-type gettering mechanism for typical contamination conditions.

  3. Synostosis of proximal phalangeal bases for loss of distal metacarpal

    Directory of Open Access Journals (Sweden)

    Pankaj Jindal

    2016-01-01

    Full Text Available A finger rendered unstable due to loss of metacarpal head can be stabilized by creating a synostosis at the base of the proximal phalanx of the affected finger with the adjacent normal finger. A cortico cancellous graft bridges the two adjacent proximal phalanges at their bases which are temporarily stabilized with an external fixator. The procedure can be done for, recurrence of giant cell tumor of metacarpal and for traumatic metacarpal loss. The procedure and long term follow up of one patient is presented who had giant cell tumor. This option should be considered before offering ray amputation. There is no micro vascular surgery involved, nor is there any donor site morbidity. The graft heals well without any absorption. The affected finger shows excellent function in the long term followup.

  4. Proximate Composition, Macro and Trace Mineral Compositions of ...

    African Journals Online (AJOL)

    The proximate composition of the whole portion was significantly (P<0.05) higher in levels of moisture and carbohydrates (9.10± 0.33 % and 62.66± 0.54%), crude protein in the flesh (41.94± 0.69% and 4.36± 0.14%) whereas fat, ash and crude fibre content (2.20± 0.05% and 0.56± 0.02%) were higher in the exoskeleton.

  5. A positioned +1 nucleosome enhances promoter-proximal pausing

    OpenAIRE

    Jimeno-Gonz?lez, Silvia; Ceballos-Ch?vez, Mar?a; Reyes, Jos? C.

    2015-01-01

    Chromatin distribution is not uniform along the human genome. In most genes there is a promoter-associated nucleosome free region (NFR) followed by an array of nucleosomes towards the gene body in which the first (+1) nucleosome is strongly positioned. The function of this characteristic chromatin distribution in transcription is not fully understood. Here we show in vivo that the +1 nucleosome plays a role in modulating RNA polymerase II (RNAPII) promoter-proximal pausing. When a +1 nucleoso...

  6. The Applications of Finite Element Analysis in Proximal Humeral Fractures

    OpenAIRE

    Yongyu Ye; Wei You; Weimin Zhu; Jiaming Cui; Kang Chen; Daping Wang

    2017-01-01

    Proximal humeral fractures are common and most challenging, due to the complexity of the glenohumeral joint, especially in the geriatric population with impacted fractures, that the development of implants continues because currently the problems with their fixation are not solved. Pre-, intra-, and postoperative assessments are crucial in management of those patients. Finite element analysis, as one of the valuable tools, has been implemented as an effective and noninvasive method to analyze...

  7. Pseudoarthrosis following proximal humeral fractures: A possible mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Rooney, P.J.; Cockshott, W.P.

    1986-01-01

    A small series of four patients with pseudarthrosis of the proximal humeral shaft is reported. These patients all had restricted movement of the shoulder joint prior to the trauma, three as a result of rheumatoid arthritis and one due a surgical fusion of the glenohumeral joint. It is suggested that pseudarthrosis is more likely under these circumstances and that pursuit of union of the fracture in such patients may not always be necessary.

  8. Bilateral trampoline fracture of the proximal tibia in a child

    Directory of Open Access Journals (Sweden)

    Enrico B Arkink, MD

    2017-12-01

    Full Text Available Trampoline fractures are transversely oriented impaction fractures of the proximal tibia sustained by young children jumping on a trampoline. Unaware of the mechanism of this specific nontraumatic fracture, physicians may fail to detect these fractures on plain radiographs, as radiological findings may be very subtle. In this case report, we present a rare case of bilateral trampoline fractures with an explanation of the trauma mechanism.

  9. Hierarchical e-beam proximity correction in mask making

    Science.gov (United States)

    Hofmann, Ulrich; Kalus, Christian K.; Rosenbusch, Anja; Jonckheere, Rik M.; Hourd, Andrew C.

    1996-05-01

    Both e-beam and optical proximity effects are still a major barrier in the transfer of an ULSI design from the CAD station to the printed result on wafer. Optical proximity effect correction (OPC) is shown to be a strong tool to improve the printing latitudes for i-line lithography of 0.35 micrometers feature sizes and below, but leads to fractal geometries around 0.1 micrometers (corresponding to 0.5 micrometers on a 5x reticle). This quantum leap in required minimum linewidth on the mask may urge mask makers to apply e-beam proximity effect correction (PEC), even more than a decrease in the reticle magnification from 5x to 4x (and further) would. For raster scan e-beams, which are typically used in mask making, correction by dose variation is not practical. Hence, PEC for these systems must be tackled by modifying the geometry of the design, in a way similar to OPC techniques. Both corrections must compromise between the accuracy achieved, which is dominated by the selected (correction and exposure) grid size, and the resulting throughput loss, caused by the use of a smaller grid size. Sigma-C now introduces a new algorithm, which enables the proximity effect correction by shape variation. It is included into CAPROX and supports hierarchy in the same manner as the other postprocessing operations. The exposure of the shape corrected pattern on a raster scan machine requires only one beam pass, whereas dose variation would require one pass for each dose. Exposures were made at IMEC and at Compugraphics. The first results on Leica EBMF10.5 and MEBES III are promising. The pure shape correction increases the line width uniformity and opens the process window for critical dimensions below 1 micrometers . Performance measurements show that the 64 Mb DRAM is a job of a few hours.

  10. Sensitivity Analysis of the Proximal-Based Parallel Decomposition Methods

    Directory of Open Access Journals (Sweden)

    Feng Ma

    2014-01-01

    Full Text Available The proximal-based parallel decomposition methods were recently proposed to solve structured convex optimization problems. These algorithms are eligible for parallel computation and can be used efficiently for solving large-scale separable problems. In this paper, compared with the previous theoretical results, we show that the range of the involved parameters can be enlarged while the convergence can be still established. Preliminary numerical tests on stable principal component pursuit problem testify to the advantages of the enlargement.

  11. Convex programming with fast proximal and linear operators

    OpenAIRE

    Wytock, Matt; Wang, Po-Wei; Kolter, J. Zico

    2015-01-01

    We present Epsilon, a system for general convex programming using fast linear and proximal operators. As with existing convex programming frameworks, users specify convex optimization problems using a natural grammar for mathematical expressions, composing functions in a way that is guaranteed to be convex by the rules of disciplined convex programming. Given such an input, the Epsilon compiler transforms the optimization problem into a mathematically equivalent form consisting only of functi...

  12. Experiments of the superconducting proximity effect between superconductor and semiconductor

    Science.gov (United States)

    Hatano, Mutsuko; Nishino, Toshikazu; Kawabe, Ushio

    1987-01-01

    Coherence length in a semiconductor induced by the superconductor proximity effect is obtained experimentally from superconducting transition temperature measurements based on the de Gennes-Werthamer-Hauser theory. It was found that the coherence length in the semiconductor increases with increase in the carrier concentration n as a function of n1/3. This result agreed with the numerical result derived from the Seto-Van Duzer theory.

  13. Transverse Stress Fracture of the Proximal Patella: A Case Report.

    Science.gov (United States)

    Atsumi, Satoru; Arai, Yuji; Kato, Ko; Nishimura, Akinobu; Nakazora, Shigeto; Nakagawa, Shuji; Ikoma, Kazuya; Fujiwara, Hiroyoshi; Sudo, Akihiro; Kubo, Toshikazu

    2016-02-01

    Among stress fractures associated with sports activities, patellar stress fracture is rare. Regarding patella stress fractures, so far only distal transverse or lateral longitudinal fractures have been reported, but there are no reports of transverse fractures occurring in the proximal patella. We describe an extremely rare case of transverse stress fracture of proximal patella in a 9-year-old athlete.A 9-year old boy, who participated in sports (sprints and Kendo) presented with left knee pain without any external injury. In plain radiographs, a fracture line was observed in the proximal 1/3 of the left patella, and a patella stress fracture was diagnosed. For treatment, because 7 months of conservative therapy showed no improvement, internal fixation was carried out using Acutrak screws, and bone union was thus achieved. Three months after the operation, he was able to return to his previous level of athletic sports activity.Regarding the mechanism of onset, it is believed that the causes are longitudinal traction force and patellofemoral contact pressure. On the other hand, the contact region of the patella with the femur changes with the flexion angle of the knee. In the current case, the fracture occurred at a site where the patella was in contact with the femur at a flexion angle of >90°, so it is believed that it occurred as a clinical condition from being subjected to repeated longitudinal traction force and patellofemoral contact pressure at a flexion angle of >90°, during the sports activities of sprints and Kendo. The nonunion of the transverse stress fracture of his proximal patella was successfully treated with internal fixation using Acutrak screws.

  14. Scanning Tunneling Spectroscopy of Proximity Superconductivity in Epitaxial Multilayer Graphene

    OpenAIRE

    Natterer, Fabian D.; Ha, Jeonghoon; Baek, Hongwoo; Zhang, Duming; Cullen, William; Zhitenev, Nikolai B.; Kuk, Young; Stroscio, Joseph A.

    2016-01-01

    We report on spatial measurements of the superconducting proximity effect in epitaxial graphene induced by a graphene-superconductor interface. Superconducting aluminum films were grown on epitaxial multilayer graphene on SiC. The aluminum films were discontinuous with networks of trenches in the film morphology reaching down to exposed graphene terraces. Scanning tunneling spectra measured on the graphene terraces show a clear decay of the superconducting energy gap with increasing separatio...

  15. The Proximate and Functional Properties of African Yam Bean ...

    African Journals Online (AJOL)

    Also, there were decreases in the gelation from 30oC to 20oC; wettability from 9 sec to 1 sec; foam capacity from 29.0 cm3 to 23.3 cm3 and viscosity from 12.30 to 23.3 cp. As a result of these improvements in both the proximate and functional properties of the flour, it could be incorporated in various foods to improve their ...

  16. Total hip arthroplasty after failed treatment of proximal femur fracture.

    Science.gov (United States)

    Tetsunaga, Tomonori; Fujiwara, Kazuo; Endo, Hirosuke; Noda, Tomoyuki; Tetsunaga, Tomoko; Sato, Toru; Shiota, Naofumi; Ozaki, Toshifumi

    2017-03-01

    Total hip arthroplasty (THA) is a good option as a salvage procedure after failed treatment of proximal femur fracture. The anatomy of the proximal femur, however, makes this surgery complicated and challenging. The purpose of this study was to evaluate the radiographic and clinical outcomes of THA after failed treatment of proximal femur fractures. We retrospectively analysed 50 consecutive THAs (42 women, 8 men; mean age 77 years) after failed treatment of a proximal femur fracture. Mean postoperative follow-up was 58.1 months. Preoperative diagnoses were femoral neck fracture in 18 hips and trochanteric fracture in 32 hips, including three that were infected. Failure resulted from cutout in 22 cases, osteonecrosis in 12, non-union with failed fixation in nine, postoperative osteoarthritis in four, and infection in three. Factors compared included radiographic assessment, complication rate, visual analogue scale (VAS), and Harris Hip Scores (HHS). Radiographic variables included femoral neck anteversion and cup and stem alignment. Absolute values of the differences in femoral neck anteversion between the affected and healthy sides were 6.0° in the femoral neck fracture group and 19.2° in the trochanteric fracture group (p = 0.01). There were no significant differences in cup anteversion (p = 0.20) or stem anteversion (p = 0.08). The complication rate was significantly higher in the trochanteric fracture group than in the femoral neck fracture group (25 vs 0%, p fracture group included three periprosthetic fractures (9.4%), two dislocations (6.3%), two surgical-site infections (6.3%), and one stem penetration (3.1%). Although no significant differences between groups were seen in the VAS or HHS at final follow-up (p = 0.32, 0.09, respectively), these measures were significantly improved at final follow-up in both groups (p fractures requires consideration of complication risk and incorrect femoral neck anteversion.

  17. How to tell the History. Proximity strategies on Argentine television

    Directory of Open Access Journals (Sweden)

    Elena Galán Fajardo

    2014-11-01

    Full Text Available This paper focuses on the analysis of a television documentary Algo habrán hecho (por la historia argentina, broadcast on Telefe and Canal 13, between 2005 and 2008. The interrelationship of discursive tools and informative and evocation strategies are very relevant in this text. Its effectiveness is related to a combined use of resources that appeal to different meanings of proximity, with the objective to make accessible the history to a popular audience.

  18. Exocrine pancreatic function following proximal small bowel resection in rats.

    Science.gov (United States)

    Gelinas, M D; Morin, C L; Morisset, J

    1982-01-01

    1. In order to assess if proximal enterectomy induces changes in the function of the exocrine pancreas, the exocrine pancreas was studied 1 week, 4 weeks, and 6 months after 50 or 75% proximal small bowel resection. 2. One week after 50 and 75% proximal small bowel resections, basal pancreatic bicarbonate outputs, studied by means of an external pancreatic fistula in conscious rats, were increased significantly over control values by 43 and 78% respectively. Four weeks after a 75% resection, the bicarbonate output was still significantly higher in resected animals than in sham operated animals. 3. The increase of volume and bicarbonate of the basal pancreatic secretion coincided with a 4-fold increase in plasma secretin concentration 1 week after resection. Both increased pancreatic secretion and plasma secretin concentration were transient. 4. The pancreatic hypersecretion was specifically reversed to control values with an I.P. injection of jejunoileal mucosa homogenate. 5. Serum gastrin and somatostatin values in intestinal mucosa and pancreas were not changed 1 and 4 weeks after enterectomy compared with sham operated animals. 6. The weight of the pancreas and its content of DNA were unaltered by resection. Amylase and chymotrypsinogen per gram pancreatic tissue and per microgram DNA were reduced 4 weeks following resections as compared with sham operated rats. After 6 months, chymotrypsinogen appeared further reduced in resected animals. 7. It is concluded that extensive proximal enterectomy in rats produced early, transient and marked increases in basal pancreatic water and bicarbonate secretion and in plasma secretin due to the loss of jejunoileal inhibitor(s), and a selective decrease in certain enzymes in pancreatic tissue. PMID:6121911

  19. Investigating magnetic proximity effects at ferrite/Pt interfaces

    Science.gov (United States)

    Collet, M.; Mattana, R.; Moussy, J.-B.; Ollefs, K.; Collin, S.; Deranlot, C.; Anane, A.; Cros, V.; Petroff, F.; Wilhelm, F.; Rogalev, A.

    2017-11-01

    Spintronic devices based on pure spin currents have drawn a lot of attention during the last few years for low energy device design. One approach to generate pure spin currents is to combine a metallic or insulating ferromagnetic layer with a non-magnetic metallic layer with a large spin-orbit coupling. A recent controversy has arisen in the possible role of magnetic proximity effects at ferromagnetic/non-magnetic interfaces, which can hamper the understanding of pure spin current generation mechanisms. While magnetic proximity effects have been frequently observed at ferromagnetic metal/non-magnetic interfaces, there are only a few studies on ferromagnetic insulator/non-magnetic interfaces. Regarding the use of ferromagnetic insulators, the focus has been mainly on yttrium iron garnet (YIG). However, investigation of induced magnetic moments at YIG/Pt interfaces has engendered contradictory results. Here, we propose to study insulating ferrites for which electronic and magnetic properties can be modulated. Magnetic proximity effects have been investigated at MnFe2O4/Pt, CoFe2O4/Pt, and NiFe2O4/Pt interfaces by X-ray circular magnetic dichroism (XMCD) measurements at the Pt L3 edge. Although hybridization with Pt seems to be different among the ferrites, we do not detect any XMCD signal as the signature of an induced magnetism in Pt. We have then studied the Fe3O4 ferrite below and above the Verwey transition temperature. No XMCD signal has been measured in the insulating or conducting phase of Fe3O4. This suggests that the absence of magnetic proximity effects at ferrite/Pt interfaces is not linked to the insulating character or not of the ferrites.

  20. Superconducting proximity effect for in situ and model layered systems

    Energy Technology Data Exchange (ETDEWEB)

    Finnemore, D.K.

    1980-01-01

    The primary drawback for in situ composites is that the ac losses are higher than for mechanically produced multifilamentary wire. To develop an understanding of the proximity effect so that analytical expressions will be available for design, a model system is developed based on PbCd. Items discussed include boundary conditions at SN interface, phonon spectral function, supercurrents through normal barriers, flux entry fields, and implications for in situ composites. (GHT)