WorldWideScience

Sample records for provisional maximum tolerable

  1. Maximum Metric Spanning Tree made Byzantine Tolerant

    OpenAIRE

    Dubois, Swan; Masuzawa, Toshimitsu; Tixeuil, Sébastien

    2011-01-01

    Self-stabilization is a versatile approach to fault-tolerance since it permits a distributed system to recover from any transient fault that arbitrarily corrupts the contents of all memories in the system. Byzantine tolerance is an attractive feature of distributed systems that permits to cope with arbitrary malicious behaviors. This paper focus on systems that are both self-stabilizing and Byzantine tolerant. We consider the well known problem of constructing a maximum metric tree in this co...

  2. Deriving a provisional tolerable intake for intravenous exposure to silver nanoparticles released from medical devices.

    Science.gov (United States)

    Savery, Laura C; Viñas, René; Nagy, Amber M; Pradeep, Prachi; Merrill, Stephen J; Hood, Alan M; Malghan, Subhas G; Goering, Peter L; Brown, Ronald P

    2017-04-01

    Silver nanoparticles (AgNP) are incorporated into medical devices for their anti-microbial characteristics. The potential exposure and toxicity of AgNPs is unknown due to varying physicochemical particle properties and lack of toxicological data. The aim of this safety assessment is to derive a provisional tolerable intake (pTI) value for AgNPs released from blood-contacting medical devices. A literature review of in vivo studies investigating critical health effects induced from intravenous (i. v.) exposure to AgNPs was evaluated by the Annapolis Accords principles and Toxicological Data Reliability Assessment Tool (ToxRTool). The point of departure (POD) was based on an i. v. 28-day repeated AgNP (20 nm) dose toxicity study reporting an increase in relative spleen weight in rats with a 5% lower confidence bound of the benchmark dose (BMDL05) of 0.14 mg/kg bw/day. The POD was extrapolated to humans by a modifying factor of 1,000 to account for intraspecies variability, interspecies differences and lack of long-term toxicity data. The pTI for long-term i. v. exposure to 20 nm AgNPs released from blood-contacting medical devices was 0.14 μg/kg bw/day. This pTI may not be appropriate for nanoparticles of other physicochemical properties or routes of administration. The methodology is appropriate for deriving pTIs for nanoparticles in general. Published by Elsevier Inc.

  3. Assessing drinking water treatment systems for safety against cyanotoxin breakthrough using maximum tolerable values.

    Science.gov (United States)

    Schmidt, Wido; Bornmann, Katrin; Imhof, Lutz; Mankiewicz, Joanna; Izydorczyk, Katarzyna

    2008-06-01

    For assessing the safety of drinking water supplies suffering cyanobacterial blooms in their water source, a methodology is proposed which relates the performance of their current treatment train to the quality of the raw water. The approach considers that different treatment trains can remove algal toxins with different efficiency. Maximum Tolerable (MT-) values of the raw water expressed by cell counts or by biovolumes of cyanobacteria were calculated. Three MT-categories were identified by colours; high risk (red), moderate risk (yellow) and no risk (green). Two treatment facilities using a conventional (1) and polishing train (2) were assessed using this methodology. For most of the time during an algal bloom the water quality could be classified as yellow which means short term higher toxin levels in comparison to the guide line in clear water were found. However, the red classification, indicating a high risk for drinking water quality was never reached. The model proposed can be understood as supplement of the common alert level framework, ALF-concept (Chorus and Bartram, Situation Assessment, Planning and Management. London and New York: E & FN Spon. 1999; House et al., Management Strategies for Toxic Blue Green Algae: Literature Review. Australia: CRC for Water Quality and Treatment. 2004).

  4. Determination of the maximum tolerated dose and the safety index of an experimental fasciolicide in cattle.

    Science.gov (United States)

    Vera, Y; Ibarra, F; Cantó, G J; Soria, O; Castillo, R; Hernández, A

    2006-04-01

    The aim of the present study was to determine the maximum tolerated dose (MTD) and the safety index (SI) of 5-chloro-2-methylthio-6-(1-napthyloxy)1H-benzimidazole, called compound alpha, in cattle. In addition, to search for possible adverse effects after treatment, the measurement of some biochemical, haematological and physiological parameters were also analysed. Eighteen crossbred heifers were divided into six groups of three animals each. Groups 1-5 received a single oral dose of 12, 36, 60, 120 and 180 mg/kg of body weight (bw) of compound alpha. Group 6 served as an untreated control. To determine the biochemical, haematological and enzymatic parameters, sera and blood samples were individually taken at 0, 4, 8, 16, 32, 128, and 720 h after treatment. Physiological parameters such as rectal temperature, heart rate (HR), respiration rate (RR) and ruminal motility were measured at the time intervals mentioned above. Estimation of the MTD and SI was obtained by using the formula reported by the Food and Drug Administration (FDA), the results showing an MTD of 180 mg/kg/bw and an SI of 15 times the recommended clinical dose. Some statistical differences were observed in a few of the biochemical, haematological and enzymatic parameters, the adverse effects being not highly representative. Alterations on HR and RR were statistically different (P<0.05) only in heifers treated with 180 mg.

  5. A practical Bayesian design to identify the maximum tolerated dose contour for drug combination trials.

    Science.gov (United States)

    Zhang, Liangcai; Yuan, Ying

    2016-11-30

    Drug combination therapy has become the mainstream approach to cancer treatment. One fundamental feature that makes combination trials different from single-agent trials is the existence of the maximum tolerated dose (MTD) contour, that is, multiple MTDs. As a result, unlike single-agent phase I trials, which aim to find a single MTD, it is often of interest to find the MTD contour for combination trials. We propose a new dose-finding design, the waterfall design, to find the MTD contour for drug combination trials. Taking the divide-and-conquer strategy, the waterfall design divides the task of finding the MTD contour into a sequence of one-dimensional dose-finding processes, known as subtrials. The subtrials are conducted sequentially in a certain order, such that the results of each subtrial will be used to inform the design of subsequent subtrials. Such information borrowing allows the waterfall design to explore the two-dimensional dose space efficiently using a limited sample size and decreases the chance of overdosing and underdosing patients. To accommodate the consideration that doses on the MTD contour may have very different efficacy or synergistic effects because of drug-drug interaction, we further extend our approach to a phase I/II design with the goal of finding the MTD with the highest efficacy. Simulation studies show that the waterfall design is safer and has higher probability of identifying the true MTD contour than some existing designs. The R package "BOIN" to implement the waterfall design is freely available from CRAN. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  6. A Bayesian adaptive design for estimating the maximum tolerated dose curve using drug combinations in cancer phase I clinical trials.

    Science.gov (United States)

    Tighiouart, Mourad; Li, Quanlin; Rogatko, André

    2017-01-30

    We present a cancer phase I clinical trial design of a combination of two drugs with the goal of estimating the maximum tolerated dose curve in the two-dimensional Cartesian plane. A parametric model is used to describe the relationship between the doses of the two agents and the probability of dose limiting toxicity. The model is re-parameterized in terms of the probabilities of toxicities at dose combinations corresponding to the minimum and maximum doses available in the trial and the interaction parameter. Trial design proceeds using cohorts of two patients receiving doses according to univariate escalation with overdose control (EWOC), where at each stage of the trial, we seek a dose of one agent using the current posterior distribution of the MTD of this agent given the current dose of the other agent. The maximum tolerated dose curve is estimated as a function of Bayes estimates of the model parameters. Performance of the trial is studied by evaluating its design operating characteristics in terms of safety of the trial and percent of dose recommendation at dose combination neighborhoods around the true MTD curve and under model misspecifications for the true dose-toxicity relationship. The method is further extended to accommodate discrete dose combinations and compared with previous approaches under several scenarios. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  7. An iterative method applied to optimize the design of PIN photodiodes for enhanced radiation tolerance and maximum light response

    Energy Technology Data Exchange (ETDEWEB)

    Cedola, A.P., E-mail: ariel.cedola@ing.unlp.edu.a [Grupo de Estudio de Materiales y Dispositivos Electronicos (GEMyDE), Dpto. Electrotecnia, Facultad de Ingenieria, Universidad Nacional de La Plata, 48 y 116, C.C. 91, La Plata 1900, Buenos Aires (Argentina); Cappelletti, M.A. [Grupo de Estudio de Materiales y Dispositivos Electronicos (GEMyDE), Dpto. Electrotecnia, Facultad de Ingenieria, Universidad Nacional de La Plata, 48 y 116, C.C. 91, La Plata 1900, Buenos Aires (Argentina); Casas, G. [Grupo de Estudio de Materiales y Dispositivos Electronicos (GEMyDE), Dpto. Electrotecnia, Facultad de Ingenieria, Universidad Nacional de La Plata, 48 y 116, C.C. 91, La Plata 1900, Buenos Aires (Argentina); Universidad Nacional de Quilmes, Roque Saenz Pena 352, Bernal 1876, Buenos Aires (Argentina); Peltzer y Blanca, E.L. [Grupo de Estudio de Materiales y Dispositivos Electronicos (GEMyDE), Dpto. Electrotecnia, Facultad de Ingenieria, Universidad Nacional de La Plata, 48 y 116, C.C. 91, La Plata 1900, Buenos Aires (Argentina); Instituto de Fisica de Liquidos y Sistemas Biologicos (IFLYSIB), CONICET - UNLP - CIC, La Plata 1900, Buenos Aires (Argentina)

    2011-02-11

    An iterative method based on numerical simulations was developed to enhance the proton radiation tolerance and the responsivity of Si PIN photodiodes. The method allows to calculate the optimal values of the intrinsic layer thickness and the incident light wavelength, in function of the light intensity and the maximum proton fluence to be supported by the device. These results minimize the effects of radiation on the total reverse current of the photodiode and maximize its response to light. The implementation of the method is useful in the design of devices whose operation point should not suffer variations due to radiation.

  8. Maximum tolerated osmolarity for peripheral administration of parenteral nutrition in pediatric patients.

    Science.gov (United States)

    Dugan, Shannon; Le, Jennifer; Jew, Rita K

    2014-09-01

    Limited data support a recommended maximum osmolarity for administration of peripheral parenteral nutrition (PPN). In this retrospective, matched-cohort study, we evaluated the incidence of phlebitis or infiltration associated with administration of PPN with an osmolarity >1000 mOsm/L vs ≤1000 mOsm/L. Patients ≤18 years old who received PPN in a 2-year period were included in the study. Data related to patient demographics, PPN constituents, and adverse effects were analyzed. A total of 352 patients met entry criteria. Overall, 139 (40%) patients experienced phlebitis or infiltration. There were no differences between patients who did or did not develop adverse events in terms of age or weight. Administration of PPN with osmolarity >1000 mOsm/L vs ≤1000 mOsm/L significantly increased infiltration (17% vs 7%; odds ratio [OR, 2.47]; 95% confidence interval [CI], 1.24-4.94; P = .01) and the combined composite end point of phlebitis or infiltration (45% vs 34%; OR, 1.65; 95% CI, 1.07-2.54; P = .02). In multivariate analysis, osmolarity >1000 mOsm/L vs ≤1000 mOsm/L was an independent risk factor for developing complications (OR, 1.67; 95% CI, 1.08-2.52; P = .02). Two of every 5 children experienced phlebitis or infiltration during administration of PPN. These adverse effects were more often observed in those who received PPN with osmolarity >1000 mOsm/L vs ≤1000 mOsm/L. With this high incidence of adverse effects, we recommend that if PPN is used, the osmolarity should not exceed 1000 mOsm/L. More important, PPN should only be used temporarily until central access is obtained. © 2013 American Society for Parenteral and Enteral Nutrition.

  9. Sequential provisional implant prosthodontics therapy.

    Science.gov (United States)

    Zinner, Ira D; Markovits, Stanley; Jansen, Curtis E; Reid, Patrick E; Schnader, Yale E; Shapiro, Herbert J

    2012-01-01

    The fabrication and long-term use of first- and second-stage provisional implant prostheses is critical to create a favorable prognosis for function and esthetics of a fixed-implant supported prosthesis. The fixed metal and acrylic resin cemented first-stage prosthesis, as reviewed in Part I, is needed for prevention of adjacent and opposing tooth movement, pressure on the implant site as well as protection to avoid micromovement of the freshly placed implant body. The second-stage prosthesis, reviewed in Part II, should be used following implant uncovering and abutment installation. The patient wears this provisional prosthesis until maturation of the bone and healing of soft tissues. The second-stage provisional prosthesis is also a fail-safe mechanism for possible early implant failures and also can be used with late failures and/or for the necessity to repair the definitive prosthesis. In addition, the screw-retained provisional prosthesis is used if and when an implant requires removal or other implants are to be placed as in a sequential approach. The creation and use of both first- and second-stage provisional prostheses involve a restorative dentist, dental technician, surgeon, and patient to work as a team. If the dentist alone cannot do diagnosis and treatment planning, surgery, and laboratory techniques, he or she needs help by employing the expertise of a surgeon and a laboratory technician. This team approach is essential for optimum results.

  10. Dose Titration Algorithm Tuning (DTAT) should supersede 'the' Maximum Tolerated Dose (MTD) in oncology dose-finding trials.

    Science.gov (United States)

    Norris, David C

    2017-01-01

    Background. Absent adaptive, individualized dose-finding in early-phase oncology trials, subsequent 'confirmatory' Phase III trials risk suboptimal dosing, with resulting loss of statistical power and reduced probability of technical success for the investigational therapy. While progress has been made toward explicitly adaptive dose-finding and quantitative modeling of dose-response relationships, most such work continues to be organized around a concept of 'the' maximum tolerated dose (MTD). The purpose of this paper is to demonstrate concretely how the aim of early-phase trials might be conceived, not as 'dose-finding', but as dose titration algorithm (DTA)-finding. Methods. A Phase I dosing study is simulated, for a notional cytotoxic chemotherapy drug, with neutropenia constituting the critical dose-limiting toxicity. The drug's population pharmacokinetics and myelosuppression dynamics are simulated using published parameter estimates for docetaxel. The amenability of this model to linearization is explored empirically. The properties of a simple DTA targeting neutrophil nadir of 500 cells/mm 3 using a Newton-Raphson heuristic are explored through simulation in 25 simulated study subjects. Results. Individual-level myelosuppression dynamics in the simulation model approximately linearize under simple transformations of neutrophil concentration and drug dose. The simulated dose titration exhibits largely satisfactory convergence, with great variance in individualized optimal dosing. Some titration courses exhibit overshooting. Conclusions. The large inter-individual variability in simulated optimal dosing underscores the need to replace 'the' MTD with an individualized concept of MTD i . To illustrate this principle, the simplest possible DTA capable of realizing such a concept is demonstrated. Qualitative phenomena observed in this demonstration support discussion of the notion of tuning such algorithms. Although here illustrated specifically in relation to

  11. Dose Titration Algorithm Tuning (DTAT) should supersede ‘the’ Maximum Tolerated Dose (MTD) in oncology dose-finding trials

    Science.gov (United States)

    Norris, David C.

    2017-01-01

    Background. Absent adaptive, individualized dose-finding in early-phase oncology trials, subsequent ‘confirmatory’ Phase III trials risk suboptimal dosing, with resulting loss of statistical power and reduced probability of technical success for the investigational therapy. While progress has been made toward explicitly adaptive dose-finding and quantitative modeling of dose-response relationships, most such work continues to be organized around a concept of ‘the’ maximum tolerated dose (MTD). The purpose of this paper is to demonstrate concretely how the aim of early-phase trials might be conceived, not as ‘dose-finding’, but as dose titration algorithm (DTA)-finding. Methods. A Phase I dosing study is simulated, for a notional cytotoxic chemotherapy drug, with neutropenia constituting the critical dose-limiting toxicity. The drug’s population pharmacokinetics and myelosuppression dynamics are simulated using published parameter estimates for docetaxel. The amenability of this model to linearization is explored empirically. The properties of a simple DTA targeting neutrophil nadir of 500 cells/mm 3 using a Newton-Raphson heuristic are explored through simulation in 25 simulated study subjects. Results. Individual-level myelosuppression dynamics in the simulation model approximately linearize under simple transformations of neutrophil concentration and drug dose. The simulated dose titration exhibits largely satisfactory convergence, with great variance in individualized optimal dosing. Some titration courses exhibit overshooting. Conclusions. The large inter-individual variability in simulated optimal dosing underscores the need to replace ‘the’ MTD with an individualized concept of MTD i . To illustrate this principle, the simplest possible DTA capable of realizing such a concept is demonstrated. Qualitative phenomena observed in this demonstration support discussion of the notion of tuning such algorithms. Although here illustrated specifically

  12. Tolerance

    DEFF Research Database (Denmark)

    Tønder, Lars

    Tolerance: A Sensorial Orientation to Politics is an experiment in re-orientation. The book is based on the wager that tolerance exceeds the more prevalent images of self-restraint and repressive benevolence because neither precludes the possibility of a more “active tolerance” motivated...... by the desire to experiment and to become otherwise. The objective is to discuss what gets lost, conceptually as well as politically, when we neglect the subsistence of active tolerance within other practices of tolerance, and to develop a theory of active tolerance in which tolerance's mobilizing character...... the current models of restraint and benevolence, other ways of understanding the politics of democratic pluralism might be developed, which will enable us to conceive of tolerance's future in terms different than those currently on offer. Tolerance: A Sensorial Orientation to Politics develops...

  13. Tolerance

    DEFF Research Database (Denmark)

    Tønder, Lars

    Tolerance: A Sensorial Orientation to Politics is an experiment in re-orientation. The book is based on the wager that tolerance exceeds the more prevalent images of self-restraint and repressive benevolence because neither precludes the possibility of a more “active tolerance” motivated by the d...... these alternatives by returning to the notion of tolerance as the endurance of pain, linking this notion to exemplars and theories relevant to the politics of multiculturalism, religious freedom, and free speech....

  14. Tolerance

    DEFF Research Database (Denmark)

    Tønder, Lars

    Tolerance: A Sensorial Orientation to Politics is an experiment in re-orientation. The book is based on the wager that tolerance exceeds the more prevalent images of self-restraint and repressive benevolence because neither precludes the possibility of a more “active tolerance” motivated by the d...... these alternatives by returning to the notion of tolerance as the endurance of pain, linking this notion to exemplars and theories relevant to the politics of multiculturalism, religious freedom, and free speech.......Tolerance: A Sensorial Orientation to Politics is an experiment in re-orientation. The book is based on the wager that tolerance exceeds the more prevalent images of self-restraint and repressive benevolence because neither precludes the possibility of a more “active tolerance” motivated...... by the desire to experiment and to become otherwise. The objective is to discuss what gets lost, conceptually as well as politically, when we neglect the subsistence of active tolerance within other practices of tolerance, and to develop a theory of active tolerance in which tolerance's mobilizing character...

  15. Using a fixed provisional prosthesis during post-extraction healing and implant placement.

    Science.gov (United States)

    McArdle, Barry F

    2006-03-01

    Most dental patients insist on the use of provisional prostheses throughout healing and osseointegration when replacing extracted teeth with implants in esthetically sensitive areas. Removable appliances of some kind are normally used for this purpose, but patients often consider them to be too cumbersome. This can lead to decreased case acceptance and compliance with the use of the provisional restoration, which can compromise the final result of treatment. Custom fixed solutions to this problem exist, but they tend to be more complicated, less practical, and more expensive than other options now available. The Monodont bridge, a new system of prefabricated components for the creation of provisional fixed partial dentures, can be more esthetic, more retentive, more functional, more cost-effective, and more universally applicable than any other available techniques. This can raise patient tolerance of provisional prostheses and thus increase case acceptance, while fostering a more predictable esthetic result with regard to soft tissue contours and emergence profile.

  16. Ecotypic variation in growth responses to simulated herbivory: trade-off between maximum relative growth rate and tolerance to defoliation in an annual plant

    Science.gov (United States)

    Camargo, Iván D.; Tapia-López, Rosalinda; Núñez-Farfán, Juan

    2015-01-01

    It has been hypothesized that slow-growing plants are more likely to maximize above-ground biomass and fitness when defoliated by herbivores than those with an already high relative growth rate (RGR). Some populations of the annual herb Datura stramonium L. can tolerate foliar damage better than others. The physiological basis of this difference is examined here in a comparative study of two ecotypes that differ in tolerance and maximum growth rate, using a growth analytical approach. One hundred and fifty-four plants of each ecotype grown under controlled conditions were suddenly defoliated (35 % of total leaf area removed) and a similar sample size of plants remained undefoliated (control). Ontogenetic plastic changes in RGR and its growth components [net assimilation rate (NAR), specific leaf area and leaf weight ratio (LWR)] after defoliation were measured to determine whether these plastic changes maximize plant growth and fitness. Different ontogenetic phases of the response were discerned and increased RGR of defoliated plants was detected at the end of the experimental period, but brought about by a different growth component (NAR or LWR) in each ecotype. These changes in RGR are putatively related to increases in fitness in defoliated environments. At the intra-specific scale, data showed a trade-off between the ability to grow under benign environmental conditions and the ability to tolerate resource limitation due to defoliation. PMID:25725085

  17. VSRR Provisional Drug Overdose Death Counts

    Data.gov (United States)

    U.S. Department of Health & Human Services — This data contains provisional counts for drug overdose deaths based on a current flow of mortality data in the National Vital Statistics System. National...

  18. A study on provisional cements, cementation techniques, and their effects on bonding of porcelain laminate veneers.

    Science.gov (United States)

    Vinod Kumar, G; Soorya Poduval, T; Bipin Reddy; Shesha Reddy, P

    2014-03-01

    Minimal tooth preparation is required for porcelain laminate veneers, but interim restorations are a must to protect their teeth against thermal insult, chemical irritation, and to provide aesthetics. Cement remaining after the removal of the provisional restoration can impair the etching quality of the tooth surface and fit and final bonding of the porcelain laminate veneer. This in vitro study examined the tooth surface for remaining debris of cement after removal of a provisional restoration. Determine the presence of cement debris on prepared tooth surface subsequent to the removal of provisional restoration. Determine the cement with the least residue following the cleansing procedures. Determine the effect of smear layer on the amount of residual luting cement. Eighty-four extracted natural anterior teeth were prepared for porcelain laminate veneers. For half of the teeth, the smear layer was removed before luting provisional restorations. Veneer provisional restorations were fabricated and luted to teeth with six bonding methods: varnish combined with glass ionomer cement (GIC), varnish combined with resin modified GIC, varnish, spot etching combined with dual-cure luting cement, adhesive combined with GIC, adhesive combined with resin modified GIC, and adhesive, spot etching combined with dual-cure luting cement. After removal of provisional restorations 1 week later, the tooth surface was examined for residual luting material with SEM. Traces of cement debris were found on all the prepared teeth surfaces for all six groups which were cemented with different methods. Cement debris was seen on teeth subsequent to the removal of provisional's. Dual-cure cement had the least residue following the cleansing procedures. Presence of smear layer had no statistical significance in comparison with cement residue. With the use of adhesive the cement debris was always found to be more than with the use of varnish. GIC showed maximum residual cement followed by dual-cure.

  19. The fixed/detachable implant provisional prosthesis.

    Science.gov (United States)

    Cibirka, R M; Linebaugh, M L

    1997-06-01

    Interim modification and management of a complete denture following surgical uncovering of dental implants can be time-intensive and may fail to provide adequate patient benefit until the definitive prosthesis can be completed. Inadequate interim management can result in functional and tissue difficulties. Modification of the conventional complete denture to a fixed/detachable provisional prosthesis in a one-stage procedure provides the patient an opportunity to experience a fixed prosthesis. The incorporation of fixed, provisional cylinders to the existing denture base using autopolymerizing acrylic resin with a closed-mouth technique is described. The peripheral regions are reduced and the distal extension shortened to resemble a fixed/detachable prosthesis. This conversion technique can provide patient satisfaction and comfort until delivery of the definitive prosthesis. Esthetic concerns, home care problems, or patient difficulties with the provisional prosthesis can be rectified in the final prosthesis.

  20. Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells.

    Science.gov (United States)

    Vives, Marta; Ginestà, Mireia M; Gracova, Kristina; Graupera, Mariona; Casanovas, Oriol; Capellà, Gabriel; Serrano, Teresa; Laquente, Berta; Viñals, Francesc

    2013-11-15

    In this article, the effectiveness of a multi-targeted chemo-switch (C-S) schedule that combines metronomic chemotherapy (MET) after treatment with the maximum tolerated dose (MTD) is reported. This schedule was tested with gemcitabine in two distinct human pancreatic adenocarcinoma orthotopic models and with cyclophosphamide in an orthotopic ovarian cancer model. In both models, the C-S schedule had the most favourable effect, achieving at least 80% tumour growth inhibition without increased toxicity. Moreover, in the pancreatic cancer model, although peritoneal metastases were observed in control and MTD groups, no dissemination was observed in the MET and C-S groups. C-S treatment caused a decrease in angiogenesis, and its effect on tumour growth was similar to that produced by the MTD followed by anti-angiogenic DC101 treatment. C-S treatment combined an increase in thrombospondin-1 expression with a decrease in the number of CD133+ cancer cells and triple-positive CD133+/CD44+/CD24+ cancer stem cells (CSCs). These findings confirm that the C-S schedule is a challenging clinical strategy with demonstrable inhibitory effects on tumour dissemination, angiogenesis and CSCs. Copyright © 2013 UICC.

  1. MAK and BAT values list 2017. Maximum permissible concentrations at the place of work and biological tolerance values for working materials; MAK- und BAT-Werte-Liste 2017. Maximale Arbeitsplatzkonzentrationen und Biologische Arbeitsstofftoleranzwerte

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2017-08-01

    The MAK and BAT values list 2017 includes the maximum permissible concentrations at the place of work and biological tolerance values for working materials. The following working materials are covered: carcinogenic working materials, sensitizing materials and aerosols. The report discusses the restriction of exposure peaks, skin resorption, MAK (maximum working place concentration) values during pregnancy, germ cell mutagens and specific working materials. Importance and application of BAT (biological working material tolerance) values, list of materials, carcinogens, biological guide values and reference values are also included.

  2. MAK and BAT values list 2015. Maximum permissible concentrations at the place of work and biological tolerance values for working materials; MAK- und BAT-Werte-Liste 2015. Maximale Arbeitsplatzkonzentrationen und Biologische Arbeitsstofftoleranzwerte

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-11-01

    The book on the MAK (maximum permissible concentrations at the place of work) and BAT (biological tolerance values for working materials) value list 2015 includes the following chapters: (a) Maximum permissible concentrations at the place of work: definition, application and determination of MAT values, list of materials; carcinogenic working materials, sensibilizing working materials, aerosols, limiting the exposition peaks, skin resorption, MAK values during pregnancy, germ cell mutagens, specific working materials; (b) Biological tolerance values for working materials: definition and application of BAT values, list of materials, carcinogenic working materials, biological guide values, biological working material reference values.

  3. 14 CFR 121.207 - Provisionally certificated airplanes: Operating limitations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Provisionally certificated airplanes... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.207 Provisionally certificated airplanes: Operating limitations. In...

  4. VSRR - Provisional monthly number of live births by state

    Data.gov (United States)

    U.S. Department of Health & Human Services — https://www.cdc.gov/nchs/products/vsrr/provisional-tables.htm Monthly provisional counts of births are provided by state of residence (50 states, District of...

  5. VSRR - Provisional monthly number of deaths by state

    Data.gov (United States)

    U.S. Department of Health & Human Services — https://www.cdc.gov/nchs/products/vsrr/provisional-tables.htm Monthly provisional counts of deaths and infant deaths are provided by state of residence (50 states,...

  6. Bacterial adhesion of porphyromonas gingivalis on provisional fixed prosthetic materials

    Directory of Open Access Journals (Sweden)

    Mustafa Zortuk

    2010-01-01

    Conclusion : The quantity of bacterial adhesion and surface roughness differed among the assessed provisional fixed prosthodontic materials. The light-polymerized provisional material Revotek LC had rougher surface and more bacterial adhesion compared with the others.

  7. Generalized provisional seed zones for native plants

    Science.gov (United States)

    Andrew D. Bower; J. Bradley St.Clair; Vicky. Erickson

    2014-01-01

    Deploying well-adapted and ecologically appropriate plant materials is a core component of successful restoration projects. We have developed generalized provisional seed zones that can be applied to any plant species in the United States to help guide seed movement. These seed zones are based on the intersection of high-resolution climatic data for winter minimum...

  8. INTERACTIVE NAME PLACEMENT FOR PROVISIONAL MAPS.

    Science.gov (United States)

    Goldberg, Jeffrey L.; Miller, Thomas C.

    1983-01-01

    Computer generation and placement of map type has been refined into a production mode at Mid-Continent Mapping Center (MCMC) for USGS 1:24,000- and 1:25,000-scale Provisional maps. The map collar program is written in FORTRAN using batch processing that allows the program to work in the background.

  9. VSRR - Quarterly provisional estimates for infant mortality

    Data.gov (United States)

    U.S. Department of Health & Human Services — Provisional estimates of infant mortality (deaths of infants under 1 year per 1,000 live births), neonatal mortality (deaths of infants aged 0-27 days per 1,000 live...

  10. Assessment of maximum tolerated dose of a new herbal drug, Semelil (ANGIPARSTM in patients with diabetic foot ulcer: A Phase I clinical trial

    Directory of Open Access Journals (Sweden)

    Heshmat R

    2008-04-01

    Full Text Available Background and the purpose of the study: In many cases of diabetic foot ulcer (DFU management, wound healing is incomplete, and wound closure and epithelial junctional integrity are rarely achieved. Our aim was to evaluate the maximum tolerated dose (MTD and dose-limiting toxicity (DLT of Semelil (ANGIPARSTM, a new herbal compound for wound treatment in a Phase I clinical trial.Methods: In this open label study, six male diabetic patients with a mean age of 57±7.6 years were treated with escalating intravenous doses of Semelil, which started at 2 cc/day to 13.5 cc/day for 28 days. Patients were assessed with a full physical exam; variables which analyzed included age, past history of diabetes and its duration, blood pressure, body temperature, weight, characteristics of DFU, Na, K, liver function test, Complete Blood Count and Differential(CBC & diff, serum amylase, HbA1c, PT, PTT, proteinuria, hematuria, and side effects were recorded. All the measurements were taken at the beginning of treatment, the end of week 2 and week 4. We also evaluated Semelil's side effects at the end of weeks 4 and 8 after ending therapy.Results and major conclusions: Up to the drug dose of 10 cc/day foot ulcer dramatically improved. We did not observe any clinical or laboratory side effects at this or lower dose levels in diabetic patients. With daily dose of 13.5 cc of Semelil we observed phlebitis at the infusion site, which was the only side effect. Therefore, in this study we determined the MTD of Semelil at 10 cc/day, and the only DLT was phlebitis in injection vein. The recommended dose of Semelil I.V. administration for Phase II studies was 4 cc/day.

  11. A provisional fixed partial denture for an implant prosthesis.

    Science.gov (United States)

    Hansen, Paul A; Kim, Eunghwan

    2010-01-01

    This article presents a technique for fabricating an esthetic provisional restoration on multiple implants. Fabricating a provisional restoration allows the dentist to make a replica of the desired restoration. The incisal edge can be placed for esthetics and function in the new provisional restoration, allowing patients to evaluate comfort and test their ability to speak with the contour of the provisional restoration. Patients can evaluate both the ease of cleaning the restoration and how tissue esthetics can be duplicated to their satisfaction. By adding acrylic resin to or removing it from the provisional, the dentist can easily change the restoration until the patient is satisfied with the esthetic and functional result. This technique will allow the dentist to fabricate the provisional prosthesis quickly, while the patient is in the chair.

  12. Fixed and removable provisional options for patients undergoing implant treatment.

    Science.gov (United States)

    Cho, Sang-Choon; Shetty, Saphal; Froum, Stuart; Elian, Nicolas; Tarnow, Dennis

    2007-11-01

    The provisional phase of treatment can be the most challenging aspect of implant dentistry. The techniques available today include removable, tooth-supported, and implant-retained provisional restorations. The selection of the type of provisional prosthesis should be based on esthetic demands, functional requirements, duration, and ease of fabrication. This article includes a review of 118 articles from peer-reviewed journals published in English from January 1986 to February 2007. This review was performed using MEDLINE. The indications, advantages, and disadvantages of the various provisional restorations are discussed.

  13. 2012 Provisional classification criteria for polymyalgia rheumatica

    DEFF Research Database (Denmark)

    Dasgupta, Bhaskar; Cimmino, Marco A; Kremers, Hilal Maradit

    2012-01-01

    % and specificity to 81%. According to these provisional classification criteria, patients ≥50 years old presenting with bilateral shoulder pain, not better explained by an alternative pathology, can be classified as having PMR in the presence of morning stiffness >45 minutes, elevated C-reactive protein and......The objective of this study was to develop European League Against Rheumatism/American College of Rheumatology classification criteria for polymyalgia rheumatica (PMR). Candidate criteria were evaluated in a 6-month prospective cohort study of 125 patients with new-onset PMR and 169 non......-PMR comparison subjects with conditions mimicking PMR. A scoring algorithm was developed based on morning stiffness >45 minutes (2 points), hip pain/limited range of motion (1 point), absence of rheumatoid factor and/or anti-citrullinated protein antibody (2 points), and absence of peripheral joint pain (1 point...

  14. Metronomic chemotherapy: an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance.

    Science.gov (United States)

    Kareva, Irina; Waxman, David J; Lakka Klement, Giannoula

    2015-03-28

    The administration of chemotherapy at reduced doses given at regular, frequent time intervals, termed 'metronomic' chemotherapy, presents an alternative to standard maximal tolerated dose (MTD) chemotherapy. The primary target of metronomic chemotherapy was originally identified as endothelial cells supporting the tumor vasculature, and not the tumor cells themselves, consistent with the emerging concept of cancer as a systemic disease involving both tumor cells and their microenvironment. While anti-angiogenesis is an important mechanism of action of metronomic chemotherapy, other mechanisms, including activation of anti-tumor immunity and a decrease in acquired therapeutic resistance, have also been identified. Here we present evidence supporting a mechanistic explanation for the improved activity of cancer chemotherapy when administered on a metronomic, rather than an MTD schedule and discuss the implications of these findings for further translation into the clinic. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  15. Biomechanical impact of provisional stenting and balloon dilatation on coronary bifurcation: clinical implications.

    Science.gov (United States)

    Chen, Henry Y; Al-Saadon, Khalid; Louvard, Yves; Kassab, Ghassan S

    2017-07-01

    In-stent restenosis (ISR) and stent thrombosis remain clinically significant problems for bifurcations. Although the role of wall shear stress (WSS) has been well investigated, the role of circumferential wall stresses (CWS) has not been well studied in provisional stenting with and without final kissing balloon (FKB). We hypothesized that the perturbation of CWS at the SB in provisional stenting and balloon dilatation is an important factor in addition to WSS, and, hence, may affect restenosis rates (i.e., higher CWS correlates with higher restenosis). To test this hypothesis, we developed computational models of stent, FKB at bifurcation, and finite element simulations that considered both fluid and solid mechanics of the vessel wall. We computed the stress ratio (CWS/WSS) to show potential correlation with restenosis in clinical studies (i.e., higher stress ratio correlates with higher restenosis). Our simulation results show that stenting in the main branch (MB) increases the maximum CWS in the side branch (SB) and, hence, yields a higher stress ratio in the SB, as compared with the MB. FKB dilatation decreases the CWS and increases WSS, which collectively lowers the stress ratio in the SB. The changes of stress ratio were correlated positively with clinical data in provisional stenting and FKB. Both fluid and solid mechanics need to be evaluated when considering various stenting techniques at bifurcations, as solid stresses also play an important role in clinical outcome. An integrative index of bifurcation mechanics is the stress ratio that considers both CWS and WSS.NEW & NOTEWORTHY Although the role of wall shear stress (WSS) has been well investigated, the role of circumferential wall stresses (CWS) has not been well studied in provisional stenting with and without final kissing balloon. Both fluid and solid mechanics need to be evaluated when considering various stenting techniques at bifurcations. An integrative index of bifurcation mechanics is the

  16. Acute administration of tramadol and tapentadol at effective analgesic and maximum tolerated doses causes hepato- and nephrotoxic effects in Wistar rats.

    Science.gov (United States)

    Barbosa, Joana; Faria, Juliana; Leal, Sandra; Afonso, Luís Pedro; Lobo, João; Queirós, Odília; Moreira, Roxana; Carvalho, Félix; Dinis-Oliveira, Ricardo Jorge

    2017-08-15

    Tramadol and tapentadol are two atypical synthetic opioid analgesics, with monoamine reuptake inhibition properties. Mainly aimed at the treatment of moderate to severe pain, these drugs are extensively prescribed for multiple clinical applications. Along with the increase in their use, there has been an increment in their abuse, and consequently in the reported number of adverse reactions and intoxications. However, little is known about their mechanisms of toxicity. In this study, we have analyzed the in vivo toxicological effects in liver and kidney resulting from an acute exposure of a rodent animal model to both opioids. Male Wistar rats were intraperitoneally administered with 10, 25 and 50mg/kg tramadol and tapentadol, corresponding to a low, effective analgesic dose, an intermediate dose and the maximum recommended daily dose, respectively, for 24h. Toxicological effects were assessed in terms of oxidative stress, biochemical and metabolic parameters and histopathology, using serum and urine samples, liver and kidney homogenates and tissue specimens. The acute exposure to tapentadol caused a dose-dependent increase in protein oxidation in liver and kidney. Additionally, exposure to both opioids led to hepatic commitment, as shown by increased serum lipid levels, decreased urea concentration, increased alanine aminotransferase and decreased butyrylcholinesterase activities. It also led to renal impairment, as reflected by proteinuria and decreased glomerular filtration rate. Histopathological findings included sinusoidal dilatation, microsteatosis, vacuolization, cell infiltrates and cell degeneration, indicating metabolic changes, inflammation and cell damage. In conclusion, a single effective analgesic dose or the maximum recommended daily dose of both opioids leads to hepatotoxicity and nephrotoxicity, with tapentadol inducing comparatively more toxicity. Whether these effects reflect risks during the therapeutic use or human overdoses requires focused

  17. VSRR - Quarterly provisional estimates for selected birth indicators

    Data.gov (United States)

    U.S. Department of Health & Human Services — Provisional estimates of selected reproductive indicators. Estimates are presented for: general fertility rates, age-specific birth rates, total and low risk...

  18. VSRR - Quarterly provisional estimates for selected indicators of mortality

    Data.gov (United States)

    U.S. Department of Health & Human Services — Provisional estimates of death rates. Estimates are presented for each of the 15 leading causes of death plus estimates for deaths attributed to drug overdose, falls...

  19. Comparative evaluation of marginal leakage of provisional crowns cemented with different temporary luting cements: In vitro study

    Science.gov (United States)

    Arora, Sheen Juneja; Arora, Aman; Upadhyaya, Viram; Jain, Shilpi

    2016-01-01

    Background or Statement of Problem: As, the longevity of provisional restorations is related to, a perfect adaptation and a strong, long-term union between restoration and teeth structures, therefore, evaluation of marginal leakage of provisional restorative materials luted with cements using the standardized procedures is essential. Aims and Objectives: To compare the marginal leakage of the provisional crowns fabricated from Autopolymerizing acrylic resin crowns and bisphenol A-glycidyl dimethacrylate (BIS-GMA) resin crowns. To compare the marginal leakage of the provisional crowns fabricated from autopolymerizing acrylic resin crowns and BIS-GMA resin crowns cemented with different temporary luting cements. To compare the marginal leakage of the provisional crowns fabricated from autopolymerizing acrylic resin (SC-10) crowns cemented with different temporary luting cements. To compare the marginal leakage of the provisional crowns fabricated from BIS-GMA resin crowns (Protemp 4) cemented with different temporary luting cements. Methodology: Freshly extracted 60 maxillary premolars of approximately similar dimensions were mounted in dental plaster. Tooth reduction with shoulder margin was planned to use a customized handpiece-holding jig. Provisional crowns were prepared using the wax pattern fabricated from computer aided designing/computer aided manufacturing milling machine following the tooth preparation. Sixty provisional crowns were made, thirty each of SC-10 and Protemp 4 and were then cemented with three different luting cements. Specimens were thermocycled, submerged in a 2% methylene blue solution, then sectioned and observed under a stereomicroscope for the evaluation of marginal microleakage. A five-level scale was used to score dye penetration in the tooth/cement interface and the results of this study was analyzed using the Chi-square test, Mann–Whitney U-test, Kruskal–Wallis H-test and the results were statistically significant P crowns

  20. Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]).

    Science.gov (United States)

    Hänggi, Daniel; Etminan, Nima; Aldrich, Francois; Steiger, Hans Jakob; Mayer, Stephan A; Diringer, Michael N; Hoh, Brian L; Mocco, J; Faleck, Herbert J; Macdonald, R Loch

    2017-01-01

    We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal subarachnoid hemorrhage. Subjects with aneurysmal subarachnoid hemorrhage repaired by clipping or coiling were randomized to EG-1962 or enteral nimodipine. Subjects were World Federation of Neurological Surgeons grade 2 to 4 and had an external ventricular drain. Cohorts of 12 subjects received 100 to 1200 mg EG-1962 (9 per cohort) or enteral nimodipine (3 per cohort). The primary objective was to determine the maximum tolerated dose. Fifty-four subjects in North America were randomized to EG-1962, and 18 subjects were randomized to enteral nimodipine. The maximum tolerated dose was 800 mg. One serious adverse event related to EG-1962 (400 mg) and 2 EG-1962 dose-limiting toxicities were without clinical sequelae. There was no EG-1962-related hypotension compared with 17% (3/18) with enteral nimodipine. Favorable outcome at 90 days on the extended Glasgow outcome scale occurred in 27/45 (60%, 95% confidence interval 46%-74%) EG-1962 subjects (5/9 with 100, 6/9 with 200, 7/9 with 400, 4/9 with 600, and 5/9 with 800 mg) and 5/18 (28%, 95% confidence interval 7%-48%, relative risk reduction of unfavorable outcome; 1.45, 95% confidence interval 1.04-2.03; P=0.027) enteral nimodipine subjects. EG-1962 reduced delayed cerebral ischemia (14/45 [31%] EG-1962 versus 11/18 [61%] enteral nimodipine) and rescue therapy (11/45 [24%] versus 10/18 [56%]). EG-1962 was safe and tolerable to 800 mg, and in this, aneurysmal subarachnoid hemorrhage population was associated with reduced delayed cerebral ischemia and rescue therapy. Overall, the rate of favorable clinical outcome was greater in the EG-1962-treated group. URL: http://www.clinicaltrials.gov. Unique identifier: NCT01893190. © 2016 The Authors.

  1. Technology and the use of acrylics for provisional dentine protection.

    Science.gov (United States)

    Kapusevska, Biljana; Dereban, Nikola; Popovska, Mirjana; Nikolovska, Julijana; Radojkova Nikolovska, Vеrа; Zabokova Bilbilova, Efka; Mijoska, Aneta

    2013-01-01

    Acrylics are compounds polymerized from monomers of acrylic, metacrylic acid or acrylonitrates. The purpose of this paper is to present the technology and use of acrylics for provisional dentine protection in the practice of dental prosthodontics. For this reason, we followed 120 clinical cases from the everyday clinical practice, divided into 4 groups of 30 patients who needed prosthetic reconstruction. The first group included cases in which we applied celluloid crowns for dentine protection, for the second group we used acrylic teeth from a set of teeth for complete dentures; in the third and fourth groups the fabrication was done with the system of an impression matrix and the acrylic resin block technique respectively. In all the examined patients, the gingival index by Silness and Loe and the vitality of the dental pulp were verified clinically, after preparation and 8 days from the placement of the provisional crown. The value for dental sensitivity measured after preparation was 2.59, and 8 days after the placement of the provisional crown it bwas 3.1. From these results we can conclude that after the 8th day from the placement of the provisional crown, there was an adaptation period, characterized by a decrease in the painful sensations. The value of the Silness and Loe gingival index measured after the preparation was 1.34, and 8 days from the placement of the provisional crown was 0.94. The results inclined us to the fact that the provisional acrylic crowns facilitated the reparation of the periodontal tissue.

  2. Pesticide Tolerances

    Science.gov (United States)

    EPA regulates pesticides used to protect crops and sets limits on the amount of pesticide remaining in or on foods in the U.S. The limits on pesticides on foods are called tolerances in the U.S. (maximum residue limits (MRLs) in many other countries).

  3. La ejecución provisional de las sentencias

    OpenAIRE

    Silva Álvarez,Óscar

    2008-01-01

    Dentro de la corriente reformista del proceso civil en Chile, un lugar importante debería estar ocupado por la figura de la ejecución provisional de las sentencias judiciales, como una manifestación del derecho a la tutela judicial efectiva y un instrumento para el acortamiento de los tiempos en el proceso. El presente artículo contiene un examen teórico a la figura de la ejecución provisional, y establece las reglas técnicas de su configuración legal. También analiza los aislados casos de ta...

  4. Occlusal wear of provisional implant-supported restorations

    NARCIS (Netherlands)

    Santing, Hendrik J.; Kleverlaan, Cornelis J.; Werner, Arie; Feilzer, Albert J.; Raghoebar, Gerry M.; Meijer, Henny J. A.

    BACKGROUND: Implant-supported provisional restorations should be resistant to occlusal wear. PURPOSE: The purpose of this laboratory study was to evaluate three-body wear of three indirect laboratory composite resins, five chair side bis-acryl resin-based materials, and two chair side

  5. Evaluation of Vertical Marginal Adaptation of Provisional Crowns by ...

    African Journals Online (AJOL)

    2018-01-30

    Jan 30, 2018 ... Department of Prosthetic Dental Sciences, College of Dentistry,. King Saud University, Riyadh, Kingdom of Saudi Arabia. E‑mail: malrifaiy@hotmail.com. How to cite this article: Al Rifaiy MQ. Evaluation of vertical marginal adaptation of provisional crowns by digital microscope. Niger J Clin Pract. 2017 ...

  6. Effect of provisional cements on shear bond strength of porcelain laminate veneers.

    Science.gov (United States)

    Altintas, Subutay Han; Tak, Onjen; Secilmis, Asli; Usumez, Aslihan

    2011-08-01

    The purpose of this study was to evaluate the effect of three provisional cements and two cleaning techniques on the final bond strength of porcelain laminate veneers. The occlusal third of the crowns of forty molar teeth were sectioned and embedded in autopolymerizing acrylic resin. Dentin surfaces were polished and specimens were randomly divided into four groups (n=10). Provisional restorations were fabricated and two provisional restorations were cemented onto each tooth. Restorations were fixed with one of three different provisional cements: eugenol-free provisional cement (Cavex), calcium hydroxide (Dycal), and light-cured provisional cement (Tempond Clear). Provisional restorations were removed with either a dental explorer and air-water spray, or a cleaning bur (Opticlean). In the control group, provisional restorations were not used on the surfaces of specimens. IPS Empress 2 ceramic discs were luted with a dual-cured resin cement (Panavia F). Shear bond strength was measured using a universal testing machine. Data were statistically analyzed by ANOVA, Tukey's HSD and Dunnett tests. Surfaces were examined by scanning electronic microscopy. Significant differences were found between the control group and both the light-cured provisional cement groups and the eugenol-free provisional cement-cleaning bur group (Pprovisional cement showed the lowest bond strength values. Selection of the provisional cement is an important factor in the ultimate bond strength of the final restoration. Calcium hydroxide provisional cement and cleaning with a dental explorer are advisable.

  7. Finite element analysis of provisional structures of implant-supported complete prostheses.

    Science.gov (United States)

    Carneiro, Bruno Albuquerque; de Brito, Rui Barbosa; França, Fabiana Mantovani Gomes

    2014-04-01

    The use of provisional resin implant-supported complete dentures is a fast and safe procedure to restore mastication and esthetics of patients soon after surgery and during the adaptation phase to the new denture. This study assessed stress distribution of provisional implant-supported fixed dentures and the all-on-4 concept using self-curing acrylic resin (Tempron) and bis-acrylic resin (Luxatemp) to simulate functional loads through the three-dimensional finite element method. Solidworks software was used to build three-dimensional models using acrylic resin (Tempron, model A) and bis-acrylic resin (Luxatemp, model B) for denture captions. Two loading patterns were applied on each model: (1) right unilateral axial loading of 150 N on the occlusal surfaces of posterior teeth and (2) oblique loading vector of 150 N at 45°. The results showed that higher stress was found on the bone crest below oblique load application with a maximum value of 187.57 MPa on model A and 167.45 MPa on model B. It was concluded that model B improved stress distribution on the denture compared with model A.

  8. Dose Titration Algorithm Tuning (DTAT should supersede ‘the’ Maximum Tolerated Dose (MTD in oncology dose-finding trials [version 2; referees: 2 approved, 1 approved with reservations

    Directory of Open Access Journals (Sweden)

    David C. Norris

    2017-03-01

    Full Text Available Background. Absent adaptive, individualized dose-finding in early-phase oncology trials, subsequent ‘confirmatory’ Phase III trials risk suboptimal dosing, with resulting loss of statistical power and reduced probability of technical success for the investigational therapy. While progress has been made toward explicitly adaptive dose-finding and quantitative modeling of dose-response relationships, most such work continues to be organized around a concept of ‘the’ maximum tolerated dose (MTD. The purpose of this paper is to demonstrate concretely how the aim of early-phase trials might be conceived, not as ‘dose-finding’, but as dose titration algorithm (DTA-finding. Methods. A Phase I dosing study is simulated, for a notional cytotoxic chemotherapy drug, with neutropenia constituting the critical dose-limiting toxicity. The drug’s population pharmacokinetics and myelosuppression dynamics are simulated using published parameter estimates for docetaxel. The amenability of this model to linearization is explored empirically. The properties of a simple DTA targeting neutrophil nadir of 500 cells/mm 3 using a Newton-Raphson heuristic are explored through simulation in 25 simulated study subjects. Results. Individual-level myelosuppression dynamics in the simulation model approximately linearize under simple transformations of neutrophil concentration and drug dose. The simulated dose titration exhibits largely satisfactory convergence, with great variance in individualized optimal dosing. Some titration courses exhibit overshooting. Conclusions. The large inter-individual variability in simulated optimal dosing underscores the need to replace ‘the’ MTD with an individualized concept of MTDi . To illustrate this principle, the simplest possible DTA capable of realizing such a concept is demonstrated. Qualitative phenomena observed in this demonstration support discussion of the notion of tuning such algorithms. Although here

  9. Dose Titration Algorithm Tuning (DTAT should supersede ‘the’ Maximum Tolerated Dose (MTD in oncology dose-finding trials [version 3; referees: 3 approved, 1 approved with reservations

    Directory of Open Access Journals (Sweden)

    David C. Norris

    2017-07-01

    Full Text Available Background. Absent adaptive, individualized dose-finding in early-phase oncology trials, subsequent ‘confirmatory’ Phase III trials risk suboptimal dosing, with resulting loss of statistical power and reduced probability of technical success for the investigational therapy. While progress has been made toward explicitly adaptive dose-finding and quantitative modeling of dose-response relationships, most such work continues to be organized around a concept of ‘the’ maximum tolerated dose (MTD. The purpose of this paper is to demonstrate concretely how the aim of early-phase trials might be conceived, not as ‘dose-finding’, but as dose titration algorithm (DTA-finding. Methods. A Phase I dosing study is simulated, for a notional cytotoxic chemotherapy drug, with neutropenia constituting the critical dose-limiting toxicity. The drug’s population pharmacokinetics and myelosuppression dynamics are simulated using published parameter estimates for docetaxel. The amenability of this model to linearization is explored empirically. The properties of a simple DTA targeting neutrophil nadir of 500 cells/mm 3 using a Newton-Raphson heuristic are explored through simulation in 25 simulated study subjects. Results. Individual-level myelosuppression dynamics in the simulation model approximately linearize under simple transformations of neutrophil concentration and drug dose. The simulated dose titration exhibits largely satisfactory convergence, with great variance in individualized optimal dosing. Some titration courses exhibit overshooting. Conclusions. The large inter-individual variability in simulated optimal dosing underscores the need to replace ‘the’ MTD with an individualized concept of MTDi . To illustrate this principle, the simplest possible DTA capable of realizing such a concept is demonstrated. Qualitative phenomena observed in this demonstration support discussion of the notion of tuning such algorithms. Although here

  10. Bacterial leakage of provisional restorative materials used in endodontics.

    Science.gov (United States)

    Hartwell, Gary R; Loucks, Carina A; Reavley, Brenton A

    2010-04-01

    To test the bacterial sealing ability of commonly used provisional endodontic restorative materials. This study investigated Cavit (3M ESPE), Ketac (3M ESPE), DuoTemp (Coltane/Whaledent), and a combination technique using Ketac and Cavit. One hundred molars were randomly selected and then mounted in an apparatus that isolated the crown portion of the tooth. Provisional restorative materials were placed in an open access following manufacturer guidelines. Streptococcus mutans was applied to the samples, and results were tabulated over the course of 4 weeks. Cavit and DuoTemp performed the best, and Ketac performed the worst. After 14 days, however, all materials leaked in over half of the samples. No material can be recommended as superior in providing a reliable seal after 14 days.

  11. Provisional Crown Dislodgement during Scuba Diving: A Case of Barotrauma

    OpenAIRE

    Meenal Nitin Gulve; Nitin Dilip Gulve

    2013-01-01

    Changes in ambient pressure, for example, during flying, diving, or hyperbaric oxygen therapy, can lead to barotrauma. Although it may seem that this issue was neglected in dental education and research in recent decades, familiarity with and understanding of these facts may be of importance for dental practitioners. We report the case of a patient who experienced barotrauma involving dislodgement of a provisional crown during scuba diving. Patients who are exposed to pressure changes as a pa...

  12. Immediately Loaded Intraorally Welded Complete-Arch Maxillary Provisional Prosthesis.

    Science.gov (United States)

    Albiero, Alberto Maria; Benato, Renato; Fincato, Andrea

    2015-01-01

    Guided implant surgery is not completely accurate when using computer-designed stereolithographic surgical guides. Complications are frequently reported when combining computer-guided flapless surgery with an immediately loaded prefabricated prosthesis. Achieving passive fit of a prefabricated prosthesis on the inserted implants the same day of the surgery can be difficult. The aim of this report is to show a new treatment approach to immediately loaded implants inserted with computer-guided surgery using an intraoral welded full-arch provisional prosthesis.

  13. In vitro color stability of provisional restorative materials

    Directory of Open Access Journals (Sweden)

    Hamid Jalali

    2012-01-01

    Aims: The purpose of this study was to investigate the effect of tea on provisional restorative materials. Setting and Design: This study was designed to measure the degree of color change of three acrylic resin provisional materials, before and after immersion in artificial saliva and artificial saliva-tea solution for 2 and 4 weeks. Materials and Methods : Three types of acrylic provisional materials (duralay, tempron, acropars TRP, were studied. Twenty disks (20±0.1 mm by 2±0.05 mm were fabricated from each material. Specimens were polished with acrylic bur using pumice and diamond polishing paste. Base line color was measured using a spectrophotometer. Ten disks were stored in artificial saliva and 10 were stored in a solution of artificial saliva and tea at room temperature. Color measurements were made after 2 and 4 weeks of immersion. Statistical analysis used: Differences in color changes were compared by two way ANOVA, across the six groups, followed by a Turkey-Kramer′s multiple comparison test. Results: For specimens immersed in artificial saliva, the color change of methyl methacrylate materials; duralay (ΔE=4.94 and tempron (ΔE=6.54, was significantly more than butyl methacrylate material; acropars (ΔE=4.10. After immersion in an artificial saliva- tea solution, tempron exhibited less color change (ΔE=8.50 compared to duralay (ΔE=10.93 and acropars (ΔE=15.64. Conclusion: Color stability of methyl methacrylate is higher than butyl methacrylates so if provisional materials are used for extended periods of time; tempron is preferred.

  14. Provisional implants for immediate restoration of partially edentulous jaws: a clinical study.

    Science.gov (United States)

    Krennmair, Gerald; Krainhöfner, Martin; Weinländer, Michael; Piehslinger, Eva

    2008-01-01

    The aim of this study was to evaluate the use of provisional implants, which can provide patients with provisional fixed partial dentures during the healing time of augmentation procedures and/or during the osseointegration period of definitive implants until delivery of the definitive prosthesis. Thirty-one patients were consecutively included in the study. Eighteen patients (group A, primary simultaneous group) were initially treated simultaneously with provisional and definitive implants and provided with 18 interim fixed partial dentures. Thirteen patients (group B) received provisional implants in a staggered procedure. In the first stage of group B patients (augmentation phase), provisional implants were placed to bridge the augmentation phase and for anchoring 13 interim fixed partial dentures. In the second stage (secondary simultaneous group), patients of group B received provisional implants to bridge the osseointegration phase for simultaneously placed definitive implants by further use of 13 interim fixed partial dentures. All patients were followed from provisional implant and definitive implant placement to delivery of the definitive prosthesis. Loss of provisional implants and interim fixed partial dentures was noted, and stability of provisional implants was evaluated using the Periotest device. The procedures of immediate rehabilitation with fixed partial dentures using provisional implants were subjectively rated by patients with regard to satisfaction, treatment period, and acceptance. In 31 patients, 44 provisional fixed partial dentures were supported by 98 provisional implants. No provisional implant loss in group A or group B-second stage was observed. Only 3 (3%) provisional implants were lost in group B-first stage during the augmentation phase. Incidence (90.8% versus 9.2%) and stability (Periotest values: 8.6 +/- 3.9 versus 4.8 +/- 2.7) of provisional implants differed significantly between maxilla and mandible (P fixed partial dentures

  15. Effect of Provisional Cements on Shear Bond Strength of Porcelain Laminate Veneers

    Science.gov (United States)

    Altintas, Subutay Han; Tak, Onjen; Secilmis, Asli; Usumez, Aslihan

    2011-01-01

    Objectives: The purpose of this study was to evaluate the effect of three provisional cements and two cleaning techniques on the final bond strength of porcelain laminate veneers. Methods: The occlusal third of the crowns of forty molar teeth were sectioned and embedded in autopolymerizing acrylic resin. Dentin surfaces were polished and specimens were randomly divided into four groups (n=10). Provisional restorations were fabricated and two provisional restorations were cemented onto each tooth. Restorations were fixed with one of three different provisional cements: eugenol-free provisional cement (Cavex), calcium hydroxide (Dycal), and light-cured provisional cement (Tempond Clear). Provisional restorations were removed with either a dental explorer and air-water spray, or a cleaning bur (Opticlean). In the control group, provisional restorations were not used on the surfaces of specimens. IPS Empress 2 ceramic discs were luted with a dual-cured resin cement (Panavia F). Shear bond strength was measured using a universal testing machine. Data were statistically analyzed by ANOVA, Tukey’s HSD and Dunnett tests. Surfaces were examined by scanning electronic microscopy. Results: Significant differences were found between the control group and both the light-cured provisional cement groups and the eugenol-free provisional cement-cleaning bur group (P<.05). Groups that had received light-cured provisional cement showed the lowest bond strength values. Conclusions: Selection of the provisional cement is an important factor in the ultimate bond strength of the final restoration. Calcium hydroxide provisional cement and cleaning with a dental explorer are advisable. PMID:21912495

  16. Effect of Provisional Cements on Shear Bond Strength of Porcelain Laminate Veneers

    OpenAIRE

    Altintas, Subutay Han; Tak, Onjen; Secilmis, Asli; Usumez, Aslihan

    2011-01-01

    Objectives: The purpose of this study was to evaluate the effect of three provisional cements and two cleaning techniques on the final bond strength of porcelain laminate veneers. Methods: The occlusal third of the crowns of forty molar teeth were sectioned and embedded in autopolymerizing acrylic resin. Dentin surfaces were polished and specimens were randomly divided into four groups (n=10). Provisional restorations were fabricated and two provisional restorations were cemented onto each to...

  17. Provisional drivers' perceptions of the impact of displaying P plates.

    Science.gov (United States)

    Bates, Lyndel; Scott-Parker, Bridie; Darvell, Millie; Watson, Barry

    2017-11-17

    P plates (or decals) identify a driver's license status to other road users. They are a compulsory part of the graduated driver licensing system in Queensland, Australia, for drivers on a P1 (provisional 1) or P2 (provisional 2) license. This study explored the perceptions of young drivers regarding the display of P plates (decals) in Queensland, Australia. In this study, 226 young drivers with a provisional (intermediate/restricted) license completed a 30-min online survey between October 2013 and June 2014. t Tests were used to compare the opinions of people who displayed their plates nearly always with those who displayed them less frequently. Participants approved of the requirement to display P plates with 69% of those on a P1 license and 79% on a P2 license supporting the condition to display P1 (red) plates. Participants on a P1 license (62%) and a P2 license (68%) also approved the requirement to display P2 (green) plates. However, young drivers also perceived that the display of P plates (measured from 1 = never to 5 = nearly all the time) enabled newly licensed drivers to be targeted by police and other drivers (those who do not always display P plates: M = 3.72, SD = 0.94; those who nearly always display P plates: M = 3.43, SD = 1.09). The study findings suggest that participants who nearly always display their P plates are more likely to report that having to display their plates resulted in them driving more carefully.

  18. Workplace exposure to nanoparticles and the application of provisional nanoreference values in times of uncertain risks

    NARCIS (Netherlands)

    van Broekhuizen, P; van Broekhuizen, F.; Cornelissen, R.; Reijnders, L.

    2012-01-01

    Nano reference values (NRVs) for occupational use of nanomaterials were tested as provisional substitute for Occupational Exposure Limits (OELs). NRVs can be used as provisional limit values until Health-Based OELs or derived no-effect levels (DNEL) become available. NRVs were defined for 8 h

  19. Provisional Admission Practices: Blending Access and Support to Facilitate Student Success

    Science.gov (United States)

    Nichols, Andrew Howard; Clinedinst, Melissa

    2013-01-01

    This report examines provisional admission as an initiative that can expand four-year college access and success for students from economically disadvantaged backgrounds. Provisional admission policies and programs enable students to enroll at an institution under specific conditions. Students are often required to meet certain academic…

  20. 76 FR 61042 - Modification of Regulations Regarding the Practice of Accepting Bonds During the Provisional...

    Science.gov (United States)

    2011-10-03

    ... Practice of Accepting Bonds During the Provisional Measures Period in Antidumping and Countervailing Duty... importers directly responsible for the payment of AD and CVD duties. DATES: This Final Rule is effective... practice of accepting bonds during the provisional measures period in AD and CVD investigations. See...

  1. Fabrication of a screw-retained fixed provisional prosthesis supported by dental implants.

    Science.gov (United States)

    Kökat, Ali Murat; Akça, Kivanç

    2004-03-01

    Screw-retained provisional implant-supported prostheses may have advantages over cement-retained prostheses in certain situations. This article describes a technique for fabrication of screw-retained provisional acrylic resin implant-supported prostheses from the modified metal components provided with the implant.

  2. Indirect implant-supported fixed provisional restoration in the esthetic zone: fabrication technique and treatment workflow.

    Science.gov (United States)

    Shor, Alexander; Schuler, Ralf; Goto, Yoshihiro

    2008-01-01

    Treatment objectives of an implant-supported fixed provisional restoration include shaping/preservation of the gingival soft tissue contour, functional and esthetic substitution of the missing dentition during postsurgical healing, and definitive prosthesis fabrication stages. Fixed provisional restoration can also serve as an esthetic and functional blueprint in the fabrication of the definitive restoration. Despite its common use and important indications, limited information is available on the various aspects of the provisional fabrication and treatment. This article presents a production technique and treatment workflow of a laboratory-fabricated, screw-retained fixed provisional restoration. Provisional restoration is fabricated using layering technique and internal stain characterization. The soft tissue profile of the working cast is modified according to the coronal contour of the diagnostic wax-up. Upon delivery, the provisional contour is reevaluated and modified as necessary. The developed emergence profile of the provisional restoration is transferred to the master cast via customized impression copings. Laboratory-fabricated implant-supported provisional restorations allow the esthetic and functional substitution of the missing dentition and the shaping of the soft tissue profile, and can act as a blueprint in the fabrication of definitive restorations.

  3. 78 FR 36571 - North American Datum of 1983 (NAD 83) Outer Continental Shelf (OCS) Provisional Official...

    Science.gov (United States)

    2013-06-18

    ... Official Protraction Diagrams in the Pacific Ocean, Hawaiian Islands Description/Date NF04-08 (Kaua'i... with this publication two NAD 83-based OCS Provisional OPDs that represent the Island of Oahu and... Title 43, Code of Federal Regulations, has created provisional versions of the basic record used for the...

  4. Early versus delayed, provisional eptifibatide in acute coronary syndromes.

    Science.gov (United States)

    Giugliano, Robert P; White, Jennifer A; Bode, Christoph; Armstrong, Paul W; Montalescot, Gilles; Lewis, Basil S; van 't Hof, Arnoud; Berdan, Lisa G; Lee, Kerry L; Strony, John T; Hildemann, Steven; Veltri, Enrico; Van de Werf, Frans; Braunwald, Eugene; Harrington, Robert A; Califf, Robert M; Newby, L Kristin

    2009-05-21

    Glycoprotein IIb/IIIa inhibitors are indicated in patients with acute coronary syndromes who are undergoing an invasive procedure. The optimal timing of the initiation of such therapy is unknown. We compared a strategy of early, routine administration of eptifibatide with delayed, provisional administration in 9492 patients who had acute coronary syndromes without ST-segment elevation and who were assigned to an invasive strategy. Patients were randomly assigned to receive either early eptifibatide (two boluses, each containing 180 microg per kilogram of body weight, administered 10 minutes apart, and a standard infusion > or = 12 hours before angiography) or a matching placebo infusion with provisional use of eptifibatide after angiography (delayed eptifibatide). The primary efficacy end point was a composite of death, myocardial infarction, recurrent ischemia requiring urgent revascularization, or the occurrence of a thrombotic complication during percutaneous coronary intervention that required bolus therapy opposite to the initial study-group assignment ("thrombotic bailout") at 96 hours. The key secondary end point was a composite of death or myocardial infarction within the first 30 days. Key safety end points were bleeding and the need for transfusion within the first 120 hours after randomization. The primary end point occurred in 9.3% of patients in the early-eptifibatide group and in 10.0% in the delayed-eptifibatide group (odds ratio, 0.92; 95% confidence interval [CI], 0.80 to 1.06; P=0.23). At 30 days, the rate of death or myocardial infarction was 11.2% in the early-eptifibatide group, as compared with 12.3% in the delayed-eptifibatide group (odds ratio, 0.89; 95% CI, 0.79 to 1.01; P=0.08). Patients in the early-eptifibatide group had significantly higher rates of bleeding and red-cell transfusion. There was no significant difference between the two groups in rates of severe bleeding or nonhemorrhagic serious adverse events. In patients who had acute

  5. VSRR - Provisional monthly and 12-month ending number of live births, deaths and infant deaths: United States

    Data.gov (United States)

    U.S. Department of Health & Human Services — https://www.cdc.gov/nchs/products/vsrr/provisional-tables.htm Monthly and 12 month-ending provisional counts of births, deaths and infant deaths are provided for the...

  6. Provisional Crown Dislodgement during Scuba Diving: A Case of Barotrauma

    Directory of Open Access Journals (Sweden)

    Meenal Nitin Gulve

    2013-01-01

    Full Text Available Changes in ambient pressure, for example, during flying, diving, or hyperbaric oxygen therapy, can lead to barotrauma. Although it may seem that this issue was neglected in dental education and research in recent decades, familiarity with and understanding of these facts may be of importance for dental practitioners. We report the case of a patient who experienced barotrauma involving dislodgement of a provisional crown during scuba diving. Patients who are exposed to pressure changes as a part of their jobs or hobbies and their dentists should know the causes of barotrauma. In addition, the clinician must be aware of the possible influence of pressure changes on the retention of dental components.

  7. [Clinical evaluation of "All-on-Four" provisional prostheses reinforced with carbon fibers].

    Science.gov (United States)

    Li, Bei-bei; Lin, Ye; Cui, Hong-yan; Hao, Qiang; Xu, Jia-bin; Di, Ping

    2016-02-18

    To assess the clinical effects of carbon fiber reinforcement on the "All-on-Four" provisional prostheses. Provisional prostheses were divided into control group and carbon fiber reinforcing group according to whether carbon fiber reinforcement was used in the provisional prostheses base resin. In our study, a total of 60 patients (32 males and 28 females) with 71 provisional prostheses(28 maxilla and 43 mandible)were enrolled between April 2008 and December 2012 for control group; a total of 23 patients (13 males and 10 females) with 28 provisional prostheses (9 maxillas and 19 mandibles) were enrolled between January 2013 and March 2014 for carbon fiber reinforcing group. The information of provisional prostheses in the patients was recorded according to preoperative examination. We used the date of definitive prosthesis restoration as the cut-off point, observing whether fracture occurred on the provisional prostheses in the two groups. Additionally we observed whether fiber exposure occurred on the tissue surface of the provisional prostheses and caused mucosal irritation. The interface between the denture base resin and the fibers was examined using scanning electron microscopy (SEM). The age [(57.3 ± 10.1) years vs.(55.1 ± 11.4) years], gender (32 males and 28 females vs. 13 males and 10 females), maxilla and mandible distributions (28 maxillas and 43 mandibles vs. 9 maxillas and 19 mandibles), the number of extraction jaws (46 vs. 23), the average using time [(7.8 ± 1.3) months vs. (7.5 ± 1.1) months], and the opposing dentition distributions of provisional prostheses of the patients showed no significant differences between the control and reinforcing groups. There were 21(29.6%) fractures that occurred on the 71 provisional prostheses in the control group; there was no fracture that occurred on the 28 provisional prosthesesin the carbon fiber reinforcing group. The fracture rate of the carbon fiber reinforcing group was significantly lower than that of

  8. Maximum Autocorrelation Factorial Kriging

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg; Conradsen, Knut; Pedersen, John L.

    2000-01-01

    This paper describes maximum autocorrelation factor (MAF) analysis, maximum autocorrelation factorial kriging, and its application to irregularly sampled stream sediment geochemical data from South Greenland. Kriged MAF images are compared with kriged images of varimax rotated factors from...

  9. VSRR - State and National Provisional Counts for Live Births, Deaths, and Infant Deaths

    Data.gov (United States)

    U.S. Department of Health & Human Services — NOTES: Figures include all revisions received from the states and, therefore, may differ from those previously published. Data are provisional and are subject to...

  10. A provisional gene regulatory atlas for mouse heart development.

    Science.gov (United States)

    Chen, Hailin; VanBuren, Vincent

    2014-01-01

    Congenital Heart Disease (CHD) is one of the most common birth defects. Elucidating the molecular mechanisms underlying normal cardiac development is an important step towards early identification of abnormalities during the developmental program and towards the creation of early intervention strategies. We developed a novel computational strategy for leveraging high-content data sets, including a large selection of microarray data associated with mouse cardiac development, mouse genome sequence, ChIP-seq data of selected mouse transcription factors and Y2H data of mouse protein-protein interactions, to infer the active transcriptional regulatory network of mouse cardiac development. We identified phase-specific expression activity for 765 overlapping gene co-expression modules that were defined for obtained cardiac lineage microarray data. For each co-expression module, we identified the phase of cardiac development where gene expression for that module was higher than other phases. Co-expression modules were found to be consistent with biological pathway knowledge in Wikipathways, and met expectations for enrichment of pathways involved in heart lineage development. Over 359,000 transcription factor-target relationships were inferred by analyzing the promoter sequences within each gene module for overrepresentation against the JASPAR database of Transcription Factor Binding Site (TFBS) motifs. The provisional regulatory network will provide a framework of studying the genetic basis of CHD.

  11. A provisional gene regulatory atlas for mouse heart development.

    Directory of Open Access Journals (Sweden)

    Hailin Chen

    Full Text Available Congenital Heart Disease (CHD is one of the most common birth defects. Elucidating the molecular mechanisms underlying normal cardiac development is an important step towards early identification of abnormalities during the developmental program and towards the creation of early intervention strategies. We developed a novel computational strategy for leveraging high-content data sets, including a large selection of microarray data associated with mouse cardiac development, mouse genome sequence, ChIP-seq data of selected mouse transcription factors and Y2H data of mouse protein-protein interactions, to infer the active transcriptional regulatory network of mouse cardiac development. We identified phase-specific expression activity for 765 overlapping gene co-expression modules that were defined for obtained cardiac lineage microarray data. For each co-expression module, we identified the phase of cardiac development where gene expression for that module was higher than other phases. Co-expression modules were found to be consistent with biological pathway knowledge in Wikipathways, and met expectations for enrichment of pathways involved in heart lineage development. Over 359,000 transcription factor-target relationships were inferred by analyzing the promoter sequences within each gene module for overrepresentation against the JASPAR database of Transcription Factor Binding Site (TFBS motifs. The provisional regulatory network will provide a framework of studying the genetic basis of CHD.

  12. Effect of nightguard vital bleaching gel on the color stability of provisional restorative materials

    OpenAIRE

    Salwa Omar Bajunaid

    2016-01-01

    Purpose: To assess the hypothesis that there was no difference in effect of 10% and 15% tooth bleaching agents on color stability of materials used for provisional fixed dental prosthesis. Methodology: Fifteen samples from two materials used for provisional fixed dental prosthesis: methacrylate-based and composite-based materials and 15 preformed polycarbonate crowns soaked in bleaching gel or distilled water. Spectrophotometer recorded color of specimens at baseline, after 3, 7, and 14 d...

  13. Evaluation of surface physical properties of acrylic resins for provisional prosthesis

    OpenAIRE

    Sérgio Paulo Hilgenberg; Emigdio Enrique Orellana-Jimenez; Wilmer Fabian Sepúlveda-Navarro; Beatriz Elena Arana-Correa; Dario César Teixeira Alves; Nara Hellen Campanha

    2008-01-01

    Acrylic resins used for provisional prostheses should have satisfactory superficial characteristics in order to ensure gingival health and low bacterial attachment. The purpose of the present study was to evaluate the superficial roughness and contact angle after two types of polishing and the Vickers hardness of three acrylic resins (Duralay - G1, Dencrilay - G2, and Dencor - G3), all shade 66, indicated for provisional fixed prostheses. Five 20 x 3 ± 1 mm diameter discoid specimens were obt...

  14. In Vitro Fit and Cementation Resistance of Provisional Crowns for Single Implant-Supported Restorations

    OpenAIRE

    Moris,Izabela Cristina Maurício; Oliveira,Juliana Elias de; Faria,Adriana Cláudia Lapria; Ribeiro,Ricardo Faria; Rodrigues,Renata Cristina Silveira

    2015-01-01

    Abstract: This study aimed to verify marginal fit and the effect of cement film thickness standardization on retention of provisional crowns made with prefabricated acrylic cylinders on abutments, using two temporary luting agents subjected or not to mechanical cycling. Provisional crowns were made from bis-acryl (Luxatemp Fluorescence) or methyl methacrylate (Duralay) resins on acrylic cylinders and marginal fit and cement film thickness were evaluated. For retention evaluation, crowns were ...

  15. Clinical evaluation of a visible light-cured indirect composite for long-term provisionalization.

    Science.gov (United States)

    Ewoldsen, Nels; Sundar, Veeraraghavan; Bennett, William; Kanya, Kevin; Magyar, Karl

    2008-01-01

    To clinically evaluate a visible light-cured (VLC) resin composite system for long-term provisional and esthetic diagnostic restorations, fabricated using indirect techniques. One-hundred and nine teeth were restored in 31 patients. Preoperational impressions were used to create VLC resin composite restorations (Radica) using indirect techniques. Restorations were relined as necessary and placed using various provisional cements at a follow-up appointment, subsequent to preparation of the teeth. Both fabricating laboratory technicians and placing dentists rated the restorations for acceptability in esthetics, marginal fit, occlusion, and functionality in various stages of provisionalization. All restorations (100%) were rated acceptable for esthetics prior to relining. After relining, a majority (93-100%) of restorations were rated acceptable in esthetic and functional criteria. At the placement of the permanent restoration, a majority (96-100%) of restorations were rated acceptable in esthetic and functional criteria. Terms of service ranged from two to seventy-six days. In combination with in vitro results, the clinical performance of the Radica VLC system for provisionalization and esthetic diagnostic restorations was judged to be acceptable. The system offers esthetics that are superior to conventional provisional restorations, and should be a valuable option to practitioners considering longer-term provisionalization in complex cases.

  16. MAK and BAT values list 2007. Maximum permissible concentrations at the place of work and biological tolerance values for working materials; MAK- und BAT-Werte-Liste 2007. Maximale Arbeitsplatzkonzentrationen und biologische Arbeitsstofftoleranzwerte

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The MAK value is the maximum permissible concentration of a substance, in gaseous, vaporous or airborne solid form, at the place of work which according to current knowledge does not affect the health or comfort of a person working there repeatedly for longer periods of time but no longer than 40 hours per week. As a rule, it is given as an average value for periods up to one day or one manshift. MAK values are established on the basis of the characteristic effects of substances but also, as far as possible, on the basis of practical working procedures and typical exposure patterns resulting from these. They are based on scientifically founded health protection criteria, not on the technical and economic options for practical implementation. Further, the cancerogenic effects, the sensitizing effects, the contribution to systematic toxicity after resorption by the skin, hazardous effects in case of pregnancy, and gonadal mutagenicity are taken in to account, and the substance is classified accordingly. (orig.)

  17. Molecular characterization of serologically atypical provisional serovars of Shigella isolates from Kolkata, India.

    Science.gov (United States)

    Dutta, Shanta; Jain, Priyanka; Nandy, Suman; Matsushita, Shigeru; Yoshida, Shin-ichi

    2014-12-01

    During 2000-2004, 13 Shigella strains that were untypable by commercially available antisera were isolated from children Shigella dysenteriae provisional serovar 204/96 (n = 3), Shigella dysenteriae provisional serovar E23507 (n = 1), Shigella dysenteriae provisional serovar I9809-73 (n = 1), Shigella dysenteriae provisional serovar 93-119 (n = 1), Shigella flexneri provisional serovar 88-893 (n = 6) and Shigella boydii provisional serovar E16553 (n = 1). In this study, characterization of those provisional serovars of Shigella was performed with respect to their antimicrobial resistance, plasmids, virulence genes and PFGE profiles. The drug resistant strains (n = 10) of Shigella identified in this study possessed various antibiotic resistance genetic markers like catA (for chloramphenicol resistance); tetA and tetB (for tetracycline resistance); dfrA1 and sul2 (for co-trimoxazole resistance); aadA1, strA and strB (for streptomycin resistance) and blaOXA-1 (for ampicillin resistance). Class 1 and/or class 2 integrons were present in eight resistant strains. Three study strains were pan-susceptible. A single mutation in the gyrA gene (serine to leucine at codon 83) was present in four quinolone resistant strains. The virulence gene ipaH (invasion plasmid antigen H) was uniformly present in all strains in this study, but the stx (Shiga toxin) and set1 (Shigella enterotoxin 1) genes were absent. Other virulence genes like ial (invasion associated locus) and sen (Shigella enterotoxin 2) were occasionally present. A large plasmid of 212 kb and of incompatibility type IncFIIA was present in the majority of the strains (n = 10) and diversity was noticed in the smaller plasmid profiles of these strains even within the same provisional serovars. PFGE profile analysis showed the presence of multiple unrelated clones among the isolates of provisional Shigella serovars. To the best of our knowledge, this is the first report on the phenotypic and

  18. Developing a provisional and national renal disease registry for Iran

    Directory of Open Access Journals (Sweden)

    Sima Ajami

    2015-01-01

    Full Text Available Background: Disease registry is a database that includes information about people suffering a special kind of disease. The aim of this study was to first identify and compare the National Renal Disease Registry (NRDR characteristics in some countries with Iran; and second, develop a provisional and NRDR for Iran. Materials and Methods: Retrieval of data of the NRDR was performed by scholars responsible in related agencies, including the Ministry of Health and Medical Education, Renal Disease charity, and data registries in the United States, United Kingdom, Malaysia, and Iran. This research was applied, and the study was descriptive-comparative. The study population consisted of the NRDR in selected countries in which data were collected by forms that were designed according to the study objectives. Sources of data were researchers, articles, books, journals, databases, websites, related documents, and people who are active in this regard, and related agencies, including the Ministry of Health and Medical Education, and patient support charity. The researchers collected data for each country based on the study objectives and then put them in comparative tables. Data were analyzed by descriptive, comparative, and theoretical methods. Results: Most of the renal transplant teams report their own results as a single center experiences. America and Britain have a preeminent national registry of renal disease compared to other countries. Conclusion: Given that control, prevention, and treatment of chronic renal diseases incur high expenses and the disease is one of leading mortality factors in Iran and across the world and since national registry system for chronic renal diseases can provide better tools and strategies to manage and evaluate patients′ characteristics as well as risk factors which eventually leads to making better decisions.

  19. Incisor reduction: a provisional aesthetic technique for traumatised teeth.

    LENUS (Irish Health Repository)

    Darby, L J

    2010-12-11

    Patients in the mixed dentition who have suffered severe extrusion or avulsion injuries often present with difficult treatment decisions, especially when the initial emergency care has been compromised. Here we describe a well-tolerated, aesthetically acceptable and conservative method for treating such patients until a definitive treatment plan is possible.

  20. Effect of different provisional cement remnant cleaning procedures including Er:YAG laser on shear bond strength of ceramics

    OpenAIRE

    Zortuk, Mustafa; Gumus, Hasan Onder; Kilinc, Halil Ibrahim; Tuncdemir, Ali Riza

    2012-01-01

    PURPOSE The purpose of this study was to evaluate the effect of provisional cement removal by different dentin cleaning protocols (dental explorer, pumice, cleaning bur, Er:YAG laser) on the shear bond strength between ceramic and dentin. MATERIALS AND METHODS In total, 36 caries-free unrestored human third molars were selected as tooth specimens. Provisional restorations were fabricated and cemented with eugenol-free provisional cement. Then, disc-shaped ceramic specimens were fabricated and...

  1. The Paediatric Rheumatology International Trials Organisation provisional criteria for the evaluation of response to therapy in juvenile dermatomyositis.

    Science.gov (United States)

    Ruperto, Nicolino; Pistorio, Angela; Ravelli, Angelo; Rider, Lisa G; Pilkington, Clarissa; Oliveira, Sheila; Wulffraat, Nico; Espada, Graciela; Garay, Stella; Cuttica, Ruben; Hofer, Michael; Quartier, Pierre; Melo-Gomes, Jose; Reed, Ann M; Wierzbowska, Malgorzata; Feldman, Brian M; Harjacek, Miroslav; Huppertz, Hans-Iko; Nielsen, Susan; Flato, Berit; Lahdenne, Pekka; Michels, Harmut; Murray, Kevin J; Punaro, Lynn; Rennebohm, Robert; Russo, Ricardo; Balogh, Zsolt; Rooney, Madeleine; Pachman, Lauren M; Wallace, Carol; Hashkes, Philip; Lovell, Daniel J; Giannini, Edward H; Gare, Boel Andersson; Martini, Alberto

    2010-11-01

    To develop a provisional definition for the evaluation of response to therapy in juvenile dermatomyositis (DM) based on the Paediatric Rheumatology International Trials Organisation juvenile DM core set of variables. Thirty-seven experienced pediatric rheumatologists from 27 countries achieved consensus on 128 difficult patient profiles as clinically improved or not improved using a stepwise approach (patient's rating, statistical analysis, definition selection). Using the physicians' consensus ratings as the "gold standard measure," chi-square, sensitivity, specificity, false-positive and-negative rates, area under the receiver operating characteristic curve, and kappa agreement for candidate definitions of improvement were calculated. Definitions with kappa values >0.8 were multiplied by the face validity score to select the top definitions. The top definition of improvement was at least 20% improvement from baseline in 3 of 6 core set variables with no more than 1 of the remaining worsening by more than 30%, which cannot be muscle strength. The second-highest scoring definition was at least 20% improvement from baseline in 3 of 6 core set variables with no more than 2 of the remaining worsening by more than 25%, which cannot be muscle strength (definition P1 selected by the International Myositis Assessment and Clinical Studies group). The third is similar to the second with the maximum amount of worsening set to 30%. This indicates convergent validity of the process. We propose a provisional data-driven definition of improvement that reflects well the consensus rating of experienced clinicians, which incorporates clinically meaningful change in core set variables in a composite end point for the evaluation of global response to therapy in juvenile DM. Copyright © 2010 by the American College of Rheumatology.

  2. Mechanical properties of four methylmethacrylate-based resins for provisional fixed restorations.

    Science.gov (United States)

    Hernandez, E P; Oshida, Y; Platt, J A; Andres, C J; Barco, M T; Brown, D T

    2004-01-01

    The use of a provisional restoration is an important phase in the treatment of the dental prosthetic patient. A good provisional restoration should satisfy the following requirements: pulpal protection, positional stability, ease in cleaning, accurate margins, wear resistance, dimensional stability, and serve as a diagnostic aid in treatment assessment and esthetics. There is a tendency for discoloration, occlusal wear, and fracture that eventually leads to unnecessary repair. Heat-processed and reinforced methacrylate-based resins have been used to improve the mechanical and physical properties of provisional restorations. Among various improvements, the interpenetrating network crosslinked PMMA (IPN) has been shown to have superior mechanical properties if manufactured through a dough compression molding process at 130 degrees C. However, there have been no published data that relate with the use of this material for fixed provisional restorations. The objective of this study was to compare four methyl methacrylate-based resins for provisional crowns and bridges with varying processing cycles, including JET [self-cure], ACRALON [heat-cured], titanium dioxide filled PMMA [heat-cured], and IPN [heat-cured denture tooth resin]. Properties studied included transverse strength, toughness, rigidity, and hardness. From the results of this study the following conclusions can be made: the IPN group may have had a lower degree of conversion as demonstrated by decreased strength, toughness, and hardness data as compared with Acralon. Increasing the polymerization cycle of unmodified Acralon resin causes a significant increase in strength.

  3. Cell Adhesion to Acrylic Custom Provisional Abutment Placed on an Immediate Implant: A Case Report.

    Science.gov (United States)

    Saito, Hanae; Hsia, Ru-Ching; Tarnow, Dennis P; Reynolds, Mark A

    2017-02-01

    This article presents the results of a scanning electron microscope (SEM) analysis of the surface of an acrylic custom provisional abutment following first disconnection from a post-extraction immediate implant placement. An implant was placed immediately after extraction, the site was grafted, and a barrier membrane was adapted for graft containment. A custom acrylic shell was then relined, polished, and steam-cleaned prior to being screwed onto the implant. After 5 months of undisturbed healing, the custom provisional abutment was disconnected for the first time and processed for SEM examination. The surface of the custom acrylic abutment revealed well-spread fibroblast-like cells with filopodia inserting into the porous surface. These observations suggest that the surface topography of the acrylic provisional restoration/ abutment can function as a substratum for cellular adhesion and may serve an important role in supporting peri-implant mucosa at the time of immediate implant placement.

  4. Immediate provisional restoration of a single-tooth implant in the esthetic zone: A case report

    Directory of Open Access Journals (Sweden)

    Po-Sung Fu

    2011-02-01

    Full Text Available Immediate implant restoration of single implants may demonstrate a positive effect on peri-implant soft tissue. Placement of a provisional restoration following implant surgery can create soft tissue contours that resemble normal gingival topography before placement of the definitive prosthesis. This article describes a staged approach of the mandibular permanent right central incisor, which was congenital missing. The proper space for restoration of the missing incisor was created through orthodontic treatment. The scheduled implant site was reconstructed using autogenous bone harvested from the chin region. After a healing period of four months, an implant was installed with the connection of a fixed provisional crown to a prefabricated temporary abutment. The soft tissue around the implant healed according to the contours of the provisional restoration and the emergence profile was used to duplicate the definitive restoration. Peri-implant esthetics was achieved through the staged approach and immediate restoration of the implant.

  5. Antibacterial effect of polyethyleneimine nanoparticles incorporated in provisional cements against Streptococcus mutans.

    Science.gov (United States)

    Shvero, Dana Kesler; Davidi, Michael Perez; Weiss, Ervin I; Srerer, Nir; Beyth, Nurit

    2010-08-01

    Frequently provisional restorations require long-term permanence in the oral cavity, thus an antibacterial effect is desirable. We hypothesized that this effect may be achieved by incorporating polyethyleneimine (PEI) nanoparticles into provisional cements. The nanoparticles antibacterial effect incorporated at 0.5%, 1%, and 2% w/w into provisional cement, was studied in vitro. The antibacterial effect against Streptococcus mutans and Enterococcus faecalis was tested using direct contact test. The data was analyzed using the ANOVA test, with the Dunnett test for multiple pairwise comparisons. A strong antibacterial effect was evident in all test groups after an aging period of 14 days against S. mutans and E. faecalis (p faecalis (p faecalis for a period of 14 days. The minimum effective concentration suggested is 1% w/w. Incorporation of nanoparticles may prevent caries and inflammation, and thereby improve the results of the prosthetic treatment. Further investigation is necessary on the effect on mechanical properties and clinical relevance.

  6. Microleakage of Glass Ionomer-based Provisional Cement in CAD/CAM-Fabricated Interim Crowns: An in vitro Study.

    Science.gov (United States)

    Farah, Ra'fat I; Al-Harethi, Naji

    2016-10-01

    The aim of this study was to compare in vitro the marginal microleakage of glass ionomer-based provisional cement with resin-based provisional cement and zinc oxide non-eugenol (ZONE) provisional cement in computer-aided design and computer-aided manufacturing (CAD/CAM)-fabricated interim restorations. Fifteen intact human premolars were prepared in a standardized manner for complete coverage of crown restorations. Interim crowns for the prepared teeth were then fabricated using CAD/CAM, and the specimens were randomized into three groups of provisional cementing agents (n = 5 each): Glass ionomer-based provisional cement (GC Fuji TEMP LT™), bisphenol-A-glycidyldimethacrylate (Bis-GMA)/ triethylene glycol dimethacrylate (TEGDMA) resin-based cement (UltraTemp® REZ), and ZONE cement (TempBond NE). After 24 hours of storage in distilled water at 37°C, the specimens were thermocycled and then stored again for 24 hours in distilled water at room temperature. Next, the specimens were placed in freshly prepared 2% aqueous methylene blue dye for 24 hours and then embedded in autopolymerizing acrylic resin blocks and sectioned in buccolingual and mesiodistal directions to assess dye penetration using a stereomicroscope. The results were statistically analyzed using a nonparametric Kruskal-Wallis test. Dunn's post hoc test with a Bonferroni correction test was used to compute multiple pairwise comparisons that identified differences among groups; the level of significance was set at p glass ionomer-based provisional cement and the ZONE cement. The provisional cementing agents exhibited different sealing abilities. The Bis-GMA/TEGDMA resin-based provisional cement exhibited the most effective favorable sealing properties against dye penetration compared with the glass ionomer-based provisional cement and conventional ZONE cement. Newly introduced glass ionomer-based provisional cement proved to be inferior to resin-based provisional cement as far as marginal microleakage

  7. Myeloid Neoplasms with Germline Predisposition: A New Provisional Entity Within the World Health Organization Classification.

    Science.gov (United States)

    Czuchlewski, David R; Peterson, LoAnn C

    2016-03-01

    The forthcoming update of the World Health Organization (WHO) classification of hematopoietic neoplasms will feature "Myeloid Neoplasms with Germline Predisposition" as a new provisional diagnostic entity. This designation will be applied to some cases of acute myeloid leukemia and myelodysplastic syndrome arising in the setting of constitutional mutations that render patients susceptible to the development of myeloid malignancies. For the diagnostic pathologist, recognizing these cases and confirming the diagnosis will demand a sophisticated grasp of clinical genetics and molecular techniques. This article presents a concise review of this new provisional WHO entity, including strategies for clinical practice. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Fracture Strength and Failure Mode of Maxillary Implant-Supported Provisional Single Crowns : A Comparison of Composite Resin Crowns Fabricated Directly Over PEEK Abutments and Solid Titanium Abutments

    NARCIS (Netherlands)

    Santing, H.J.; Meijer, Henny J.A.; Raghoebar, G.M.; Ozcan, M.

    2012-01-01

    Background: Polyetheretherketone (PEEK) temporary abutments have been recently introduced for making implant-supported provisional single crowns. Little information is available in the dental literature on the durability of provisional implant-supported restorations. Purpose: The objectives of this

  9. Maximum likely scale estimation

    DEFF Research Database (Denmark)

    Loog, Marco; Pedersen, Kim Steenstrup; Markussen, Bo

    2005-01-01

    A maximum likelihood local scale estimation principle is presented. An actual implementation of the estimation principle uses second order moments of multiple measurements at a fixed location in the image. These measurements consist of Gaussian derivatives possibly taken at several scales and...

  10. Maximum modular graphs

    NARCIS (Netherlands)

    Trajanovski, S.; Wang, H.; Van Mieghem, P.

    2012-01-01

    Modularity has been explored as an important quantitative metric for community and cluster detection in networks. Finding the maximum modularity of a given graph has been proven to be NPcomplete and therefore, several heuristic algorithms have been proposed. We investigate the problem of finding the

  11. Establishment of Maximum Voluntary Compressive Neck Tolerance Levels

    Science.gov (United States)

    2011-07-01

    Bridges Casey Pirnstill Chris Burneka John Plaga Grant Roush Biosciences and Performance Division Vulnerability Analysis Branch July 2011...S) Michael Cote, John Buhrman, Nathaniel Bridges, Casey Pirnstill, Chris Burneka, John Plaga , Grant Roush 5d. PROJECT NUMBER OSMS 5e. TASK

  12. 77 FR 63801 - Aqua-Leisure Industries, Inc., Provisional Acceptance of a Settlement Agreement and Order

    Science.gov (United States)

    2012-10-17

    ... COMMISSION Aqua-Leisure Industries, Inc., Provisional Acceptance of a Settlement Agreement and Order AGENCY... Agreement with Aqua-Leisure Industries, Inc., containing a civil penalty of $650,000.00, within twenty (20... AMERICA CONSUMER PRODUCT SAFETY COMMISSION In the Matter of: Aqua-Leisure Industries, Inc. CPSC Docket No...

  13. 75 FR 1356 - RC2 Corporation, Provisional Acceptance of a Settlement Agreement and Order

    Science.gov (United States)

    2010-01-11

    ... nationwide, and secondarily through RC2's e-commerce websites or as `sub-components' of retail items... through RC2's e-commerce Web sites or as `sub-components' of retail items distributed independently of RC2... accordance with the terms of 16 CFR 1118.20(e). Published below is a provisionally-accepted Settlement...

  14. 77 FR 4023 - Hewlett-Packard Company, Provisional Acceptance of a Settlement Agreement and Order

    Science.gov (United States)

    2012-01-26

    ... COMMISSION Hewlett-Packard Company, Provisional Acceptance of a Settlement Agreement and Order AGENCY... Agreement with Hewlett-Packard Company, containing a civil penalty of $425,000.00, within twenty (20) days... 1118.20, Hewlett-Packard Company (``HP'') and the staff (``Staff'') of the United States Consumer...

  15. 75 FR 23745 - Jo-Ann Stores, Inc., Provisional Acceptance of a Settlement Agreement and Order

    Science.gov (United States)

    2010-05-04

    ... Robbie Ducky products at its retail stores nationwide during those periods for between $5 and $10 per... COMMISSION Jo-Ann Stores, Inc., Provisional Acceptance of a Settlement Agreement and Order AGENCY: Consumer... Agreement with Jo-Ann Stores, Inc., containing a civil penalty of $50,000.00. DATES: Any interested person...

  16. Effect of nightguard vital bleaching gel on the color stability of provisional restorative materials

    Directory of Open Access Journals (Sweden)

    Salwa Omar Bajunaid

    2016-01-01

    Conclusions: Composite-based provisional material showed highest color stability when exposed to vital tooth bleaching gel, whereas methacrylate-based material was the least color stable. Polycarbonate crowns were more color stable when exposed to 15% bleaching gel as opposed to 10% bleaching gel.

  17. Effect of nightguard vital bleaching gel on the color stability of provisional restorative materials.

    Science.gov (United States)

    Bajunaid, Salwa Omar

    2016-01-01

    To assess the hypothesis that there was no difference in effect of 10% and 15% tooth bleaching agents on color stability of materials used for provisional fixed dental prosthesis. Fifteen samples from two materials used for provisional fixed dental prosthesis: methacrylate-based and composite-based materials and 15 preformed polycarbonate crowns soaked in bleaching gel or distilled water. Spectrophotometer recorded color of specimens at baseline, after 3, 7, and 14 days. Data were statistically analyzed using two-factor ANOVA test to compare the color stability of tested materials. Methyl-based provisional material exhibited statistically higher color change when exposed to 10% and 15% bleaching gel (delta EFNx01: 9.0 and 11.1, respectively) as compared to distilled water (delta EFNx01: 2.9). Delta EFNx01 of composite-based material specimens exposed to distilled water was statistically higher (6.3) than specimens exposed to 10% and 15% bleaching gel (1.5 and 1.1, respectively). Polycarbonate crowns showed a statistically lower color change when exposed to 15% (0.9) than to 10% bleaching gel (5.1) or distilled water (5.5). Composite-based provisional material showed highest color stability when exposed to vital tooth bleaching gel, whereas methacrylate-based material was the least color stable. Polycarbonate crowns were more color stable when exposed to 15% bleaching gel as opposed to 10% bleaching gel.

  18. 76 FR 49453 - CVS Pharmacy, Inc., Provisional Acceptance of a Settlement Agreement and Order

    Science.gov (United States)

    2011-08-10

    ... COMMISSION CVS Pharmacy, Inc., Provisional Acceptance of a Settlement Agreement and Order AGENCY: Consumer... Agreement with CVS Pharmacy, Inc., containing a civil penalty of $45,000.00. DATES: Any interested person... 1. In accordance with 16 CFR 1118.20, CVS Pharmacy, Inc. (``CVS'') and the U.S. Consumer Product...

  19. A provisional check list of the reptiles and amphibians of Golden Gate Highlands National Park

    Directory of Open Access Journals (Sweden)

    M.F. Bates

    1991-09-01

    Full Text Available A provisional check list of 26 reptile and amphibian species (8 frog, 8 lizard and 10 snake species occurring in Golden Gate Highlands National Park is presented. The list does not reflect the results of an intensive survey, but is a record of specimens collected in the park and preserved at the National Museum, Bloemfontein.

  20. 75 FR 26939 - Target Corporation: Provisional Acceptance of a Settlement Agreement and Order

    Science.gov (United States)

    2010-05-13

    ... settlements which it provisionally accepts under the Consumer Product Safety Act in the Federal Register in... pursuant to the Consumer Product Safety Act, 15 U.S.C. 2051-2089 (``CPSA''). The Commission is responsible...'s products consisting of the following models: Truck Carry Case; Tiny Playground Set/Dream House...

  1. Comparative in vitro evaluation of CAD/CAM vs conventional provisional crowns

    Directory of Open Access Journals (Sweden)

    Adil Othman ABDULLAH

    Full Text Available ABSTRACT Objective This study compared the marginal gap, internal fit, fracture strength, and mode of fracture of CAD/CAM provisional crowns with that of direct provisional crowns. Material and Methods An upper right first premolar phantom tooth was prepared for full ceramic crown following tooth preparation guidelines. The materials tested were: VITA CAD-Temp®, Polyetheretherketone “PEEK”, Telio CAD-Temp, and Protemp™4 (control group. The crowns were divided into four groups (n=10, Group1: VITA CAD-Temp®, Group 2: PEEK, Group 3: Telio CAD-Temp, and Group 4: Protemp™4. Each crown was investigated for marginal and internal fit, fracture strength, and mode of fracture. Statistical analysis was performed using GraphPad Prism software version 6.0. Results The average marginal gap was: VITA CAD-Temp® 60.61 (±9.99 µm, PEEK 46.75 (±8.26 µm, Telio CAD-Temp 56.10 (±5.65 µm, and Protemp™4 193.07(±35.96 µm (P0.05. Conclusions CAD/CAM fabricated provisional crowns demonstrated superior fit and better strength than direct provisional crowns.

  2. NGE64/19: Regulaci??n de la jornada laboral, con car??cter provisional

    OpenAIRE

    Universidad de Granada

    2012-01-01

    Resoluci??n de la Gerencia, de 10 de septiembre de 2012, por la que se regula la jornada laboral, con car??cter provisional, para dar cumplimiento a lo establecido en la Ley 2/2012 y en el Real Decreto Ley 20/2012.

  3. 75 FR 55777 - Pro-Pac Distributing Corp., Provisional Acceptance of a Settlement Agreement and Order

    Science.gov (United States)

    2010-09-14

    ... COMMISSION Pro-Pac Distributing Corp., Provisional Acceptance of a Settlement Agreement and Order AGENCY... Agreement with Pro-Pac Distributing Corp., containing a civil penalty of $125,000.00. DATES: Any interested... STATES OF AMERICA CONSUMER PRODUCT SAFETY COMMISSION In the Matter of: Pro-Pac Distributing Corp...

  4. Maximum Likelihood Fusion Model

    Science.gov (United States)

    2014-08-09

    Symposium of Robotics Re- search. Sienna, Italy: Springer, 2003. [12] D. Hall and J. Llinas, “An introduction to multisensor data fusion ,” Proceed- ings of...a data fusion approach for combining Gaussian metric models of an environment constructed by multiple agents that operate outside of a global... data fusion , hypothesis testing,maximum likelihood estimation, mobile robot navigation REPORT DOCUMENTATION PAGE 11. SPONSOR/MONITOR’S REPORT

  5. Heat tolerance in wheat

    DEFF Research Database (Denmark)

    Sharma, Dew Kumari

    climate, wheat is sensitive to heat stress. We need to understand how our crops will perform in these changing climatic conditions and how we can develop varieties, which are more tolerant. The PhD study focussed on understanding heat tolerance in wheat with a combined approach of plant physiology...... and quantitative genetics in particular, plant phenotyping based quantitative trait loci (QTL) discovery for a physiological trait under heat stress. Chlorophyll a fluorescence trait, Fv/Fm was used as a phenotyping tool, as it reflects the effect of heat stress on maximum photochemical efficiency of photosystem...... among cultivars due to heat stress as the GD of most of them remained similar in control and stress. The second study investigated if it was possible to use detached leaves to screen for heat tolerance instead of intact plants. The previously selected 41 cultivars, known to differ in v/Fm, were used...

  6. Costly tolerance

    African Journals Online (AJOL)

    2016-07-08

    Jul 8, 2016 ... It shows how this decision is related to the broader context of early twentieth century political life in the Netherlands. (the 'Pacification of 1917'), and it concludes with some thoughts on the costliness of true tolerance. Costly tolerance. Read online: Scan this QR code with your smart phone or mobile device.

  7. Graduate Periodontics Programs' Integration of Implant Provisionalization in Core Curricula: Implementation of CODA Standard 4-10.2.d.

    Science.gov (United States)

    Barwacz, Christopher A; Pantzlaff, Ed; Allareddy, Veerasathpurush; Avila-Ortiz, Gustavo

    2017-06-01

    The aim of this descriptive study was to provide an overview of the status of implementation of Commission on Dental Accreditation (CODA) Standard 4-10.2.d (Provisionalization of Dental Implants) by U.S. graduate periodontics programs since its introduction in 2013. Surveys were sent in May 2015 to 56 accredited postdoctoral periodontics program directors to ascertain program director characteristics; status of planning, implementation, and curriculum resulting from adoption of Standard 4-10.2.d; preferred clinical protocols for implant provisionalization; interdisciplinary educational collaborators; and competency assessment mechanisms. The survey response rate was 52% (N=29); the majority were male, aged 55 or older, and had held their position for less than ten years. Among the responding programs, 93% had formal educational curricula established in implant provisionalization. Graduate periodontics (96%) and prosthodontics (63%) faculty members were predominantly involved with curriculum planning. Of these programs, 96% used immediate implant provisionalization, with direct (chairside) provisionalization protocols (86%) being preferred over indirect protocols (14%) and polyethylethylketone provisional abutments (75%) being preferred to titanium (25%) provisional abutments. Straight and concave transmucosal emergence profile designs (46% each) were preferred in teaching, with only 8% of programs favoring convex transmucosal profiles. A majority of responding programs (67%) lacked protocols for communicating to the restorative referral a mechanism to duplicate the mature peri-implant mucosal architecture. Regional location did not play a significant role in any educational component related to implant provisionalization for these graduate periodontal programs. Overall, this study found that a clear majority of graduate periodontics programs had established formal curricula related to implant provisionalization, with substantial clinical and philosophical consensus

  8. Maximum Entropy Fundamentals

    Directory of Open Access Journals (Sweden)

    F. Topsøe

    2001-09-01

    Full Text Available Abstract: In its modern formulation, the Maximum Entropy Principle was promoted by E.T. Jaynes, starting in the mid-fifties. The principle dictates that one should look for a distribution, consistent with available information, which maximizes the entropy. However, this principle focuses only on distributions and it appears advantageous to bring information theoretical thinking more prominently into play by also focusing on the "observer" and on coding. This view was brought forward by the second named author in the late seventies and is the view we will follow-up on here. It leads to the consideration of a certain game, the Code Length Game and, via standard game theoretical thinking, to a principle of Game Theoretical Equilibrium. This principle is more basic than the Maximum Entropy Principle in the sense that the search for one type of optimal strategies in the Code Length Game translates directly into the search for distributions with maximum entropy. In the present paper we offer a self-contained and comprehensive treatment of fundamentals of both principles mentioned, based on a study of the Code Length Game. Though new concepts and results are presented, the reading should be instructional and accessible to a rather wide audience, at least if certain mathematical details are left aside at a rst reading. The most frequently studied instance of entropy maximization pertains to the Mean Energy Model which involves a moment constraint related to a given function, here taken to represent "energy". This type of application is very well known from the literature with hundreds of applications pertaining to several different elds and will also here serve as important illustration of the theory. But our approach reaches further, especially regarding the study of continuity properties of the entropy function, and this leads to new results which allow a discussion of models with so-called entropy loss. These results have tempted us to speculate over

  9. Maximum Entropy Fundamentals

    Science.gov (United States)

    Harremoeës, P.; Topsøe, F.

    2001-09-01

    In its modern formulation, the Maximum Entropy Principle was promoted by E.T. Jaynes, starting in the mid-fifties. The principle dictates that one should look for a distribution, consistent with available information, which maximizes the entropy. However, this principle focuses only on distributions and it appears advantageous to bring information theoretical thinking more prominently into play by also focusing on the "observer" and on coding. This view was brought forward by the second named author in the late seventies and is the view we will follow-up on here. It leads to the consideration of a certain game, the Code Length Game and, via standard game theoretical thinking, to a principle of Game Theoretical Equilibrium. This principle is more basic than the Maximum Entropy Principle in the sense that the search for one type of optimal strategies in the Code Length Game translates directly into the search for distributions with maximum entropy. In the present paper we offer a self-contained and comprehensive treatment of fundamentals of both principles mentioned, based on a study of the Code Length Game. Though new concepts and results are presented, the reading should be instructional and accessible to a rather wide audience, at least if certain mathematical details are left aside at a rst reading. The most frequently studied instance of entropy maximization pertains to the Mean Energy Model which involves a moment constraint related to a given function, here taken to represent "energy". This type of application is very well known from the literature with hundreds of applications pertaining to several different elds and will also here serve as important illustration of the theory. But our approach reaches further, especially regarding the study of continuity properties of the entropy function, and this leads to new results which allow a discussion of models with so-called entropy loss. These results have tempted us to speculate over the development of natural

  10. Regularized maximum correntropy machine

    KAUST Repository

    Wang, Jim Jing-Yan

    2015-02-12

    In this paper we investigate the usage of regularized correntropy framework for learning of classifiers from noisy labels. The class label predictors learned by minimizing transitional loss functions are sensitive to the noisy and outlying labels of training samples, because the transitional loss functions are equally applied to all the samples. To solve this problem, we propose to learn the class label predictors by maximizing the correntropy between the predicted labels and the true labels of the training samples, under the regularized Maximum Correntropy Criteria (MCC) framework. Moreover, we regularize the predictor parameter to control the complexity of the predictor. The learning problem is formulated by an objective function considering the parameter regularization and MCC simultaneously. By optimizing the objective function alternately, we develop a novel predictor learning algorithm. The experiments on two challenging pattern classification tasks show that it significantly outperforms the machines with transitional loss functions.

  11. Crafting tolerance

    DEFF Research Database (Denmark)

    Kirchner, Antje; Freitag, Markus; Rapp, Carolin

    2011-01-01

    Ongoing changes in social structures, orientation, and value systems confront us with the growing necessity to address and understand transforming patterns of tolerance as well as specific aspects, such as social tolerance. Based on hierarchical analyses of the latest World Values Survey (2005–08...... results show that specific institutional qualities, which reduce status anxiety, such as inclusiveness, universality, and fairness, prevail over traditional socio-economic, societal, cultural, and democratic explanations.......–08) and national statistics for 28 countries, we assess both individual and contextual aspects that influence an individual's perception of different social groupings. Using a social tolerance index that captures personal attitudes toward these groupings, we present an institutional theory of social tolerance. Our...

  12. Om tolerance

    DEFF Research Database (Denmark)

    Huggler, Jørgen

    2007-01-01

    Begrebet tolerance og dets betydninger diskuteres med henblik på en tydeliggørelse af begrebets forbindelse med stat, religion, ytringsfrihed, skeptisk erkendelsesteori, antropologi og pædagogik.......Begrebet tolerance og dets betydninger diskuteres med henblik på en tydeliggørelse af begrebets forbindelse med stat, religion, ytringsfrihed, skeptisk erkendelsesteori, antropologi og pædagogik....

  13. Deconstructing tolerance with clobazam

    Science.gov (United States)

    Wechsler, Robert T.; Sankar, Raman; Montouris, Georgia D.; White, H. Steve; Cloyd, James C.; Kane, Mary Clare; Peng, Guangbin; Tworek, David M.; Shen, Vivienne; Isojarvi, Jouko

    2016-01-01

    Objective: To evaluate potential development of tolerance to adjunctive clobazam in patients with Lennox-Gastaut syndrome. Methods: Eligible patients enrolled in open-label extension study OV-1004, which continued until clobazam was commercially available in the United States or for a maximum of 2 years outside the United States. Enrolled patients started at 0.5 mg·kg−1·d−1 clobazam, not to exceed 40 mg/d. After 48 hours, dosages could be adjusted up to 2.0 mg·kg−1·d−1 (maximum 80 mg/d) on the basis of efficacy and tolerability. Post hoc analyses evaluated mean dosages and drop-seizure rates for the first 2 years of the open-label extension based on responder categories and baseline seizure quartiles in OV-1012. Individual patient listings were reviewed for dosage increases ≥40% and increasing seizure rates. Results: Data from 200 patients were included. For patients free of drop seizures, there was no notable change in dosage over 24 months. For responder groups still exhibiting drop seizures, dosages were increased. Weekly drop-seizure rates for 100% and ≥75% responders demonstrated a consistent response over time. Few patients had a dosage increase ≥40% associated with an increase in seizure rates. Conclusions: Two-year findings suggest that the majority of patients do not develop tolerance to the antiseizure actions of clobazam. Observed dosage increases may reflect best efforts to achieve seizure freedom. It is possible that the clinical development of tolerance to clobazam has been overstated. ClinicalTrials.gov identifier: NCT00518713 and NCT01160770. Classification of evidence: This study provides Class III evidence that the majority of patients do not develop tolerance to clobazam over 2 years of treatment. PMID:27683846

  14. Vector-controlled alveolar distraction osteogenesis using an implant-fixed provisional prosthesis: a case report.

    Science.gov (United States)

    Kawashima, Wataru; Takayama, Kenichi; Fujii, Ryosuke; Matsubara, Yuuri; Kirita, Tadaaki

    2013-02-01

    This is a case report of anterosuperior alveolar distraction using an implant-fixed provisional prosthesis. Osteotomy and placement of a distraction device were performed in a healthy 69-year-old woman. To avoid lingual inclination during the distraction period, the device's rod was buried in the labial side of a provisional prosthesis supported by posterior implants. The mandibular bone was obliquely distracted by 0.3 mm every 2 days. Implant insertion was performed, and a good prognosis was anticipated. Inclination is thought to be caused by soft tissue on the lingual side. Many reports propose methods to avoid inclination, but these methods require established support from the teeth and cannot be adapted for an edentulous case. The method reported here is useful for distraction osteogenesis because it can be adapted for edentulous cases.

  15. A provisional bibliography of Asian martial arts periodicals published in Spain (1961-2009

    Directory of Open Access Journals (Sweden)

    Carlos Gutiérrez-García

    2012-07-01

    Full Text Available A provisional bibliography about Asian martial arts periodicals published in Spain from 1961, first journal’s publication date, to 2009 is presented. Asian martial arts journals were just included for preparing this bibliography. Main public documentary centres as well as personal archives were visited for information searching and data mining. Analysis process was complex due to the scarce number of this kind of publications collected in public institutions. 66 periodicals were discovered and several useful elements were detailed for their description and documentary analysis (title, type of publication, period, frequency, issues, editor, place of publication, ISSN and a brief explanation of their editorial line. Despite its provisional character, this bibliography shows the great amount and variety of data contained in these periodicals, turning into a relevant resource for studying the martial arts’ history in Spain.

  16. An Investigation Into the Integrity of Fit of Provisional Crowns Using Current Proprietary Temporary Crown Materials.

    Science.gov (United States)

    Taylor, Philip D; Georgakis, Georgios; Niggli, Jason

    2016-06-01

    Three methods of direct provisional crown construction were investigated for accuracy of marginal fit. A modified proprietary crown coping was compared to Bis GMA and isobutyl methacrylate resin provisional crowns with margins modified by using a flowable composite and 'bead on' isobutyl methacrylate respectively. Measurement was at 50x magnification at seven sites over the fit surface. Data was analyzed using SPSS version 13.0.1 and measurement compared using the Mann Whitney test set at a significance level of 0.05. Reliability was checked using the Bland Altman test. Statistical significant differences were found between the three groups. The order of best fit was Bis-GMA and flowable composite > isobutyl methacrylate with 'bead on' margins > Bis-GMA modified implant temporary coping. The clinical significance is that the Bis GMA and flowable composite combination can be used with equal confidence to traditional methods of temporarisation.

  17. The Paediatric Rheumatology International Trials Organisation provisional criteria for the evaluation of response to therapy in juvenile dermatomyositis

    DEFF Research Database (Denmark)

    Ruperto, Nicolino; Pistorio, Angela; Ravelli, Angelo

    2010-01-01

    To develop a provisional definition for the evaluation of response to therapy in juvenile dermatomyositis (DM) based on the Paediatric Rheumatology International Trials Organisation juvenile DM core set of variables....

  18. Comparative in vitro evaluation of CAD/CAM vs conventional provisional crowns.

    Science.gov (United States)

    Abdullah, Adil Othman; Tsitrou, Effrosyni A; Pollington, Sarah

    2016-01-01

    This study compared the marginal gap, internal fit, fracture strength, and mode of fracture of CAD/CAM provisional crowns with that of direct provisional crowns. An upper right first premolar phantom tooth was prepared for full ceramic crown following tooth preparation guidelines. The materials tested were: VITA CAD-Temp®, Polyetheretherketone "PEEK", Telio CAD-Temp, and Protemp™4 (control group). The crowns were divided into four groups (n=10), Group1: VITA CAD-Temp®, Group 2: PEEK, Group 3: Telio CAD-Temp, and Group 4: Protemp™4. Each crown was investigated for marginal and internal fit, fracture strength, and mode of fracture. Statistical analysis was performed using GraphPad Prism software version 6.0. The average marginal gap was: VITA CAD-Temp® 60.61 (±9.99) µm, PEEK 46.75 (±8.26) µm, Telio CAD-Temp 56.10 (±5.65) µm, and Protemp™4 193.07(±35.96) µm (PCAD-Temp® 124.94 (±22.96) µm, PEEK 113.14 (±23.55) µm, Telio CAD-Temp 110.95 (±11.64) µm, and Protemp™4 143.48(±26.74) µm. The average fracture strength was: VITA CAD-Temp® 361.01 (±21.61) N, PEEK 802.23 (±111.29) N, Telio CAD-Temp 719.24 (±95.17) N, and Protemp™4 416.40 (±69.14) N. One-way ANOVA test showed a statistically significant difference for marginal gap, internal gap, and fracture strength between all groups (p0.05). CAD/CAM fabricated provisional crowns demonstrated superior fit and better strength than direct provisional crowns.

  19. Immediate provisional restoration of a single-tooth implant in the esthetic zone: A case report

    OpenAIRE

    Fu, Po-Sung; Wu, Yi-Min; Tsai, Ching-Fang; Huang, Ta-Ko; Chen, Wen-Cheng; Hung, Chun-Cheng; 傅柏松,; 吳逸民,; 蔡菁芳,; 黃大可; 陳文正,; 洪純正,

    2011-01-01

    Immediate implant restoration of single implants may demonstrate a positive effect on peri-implant soft tissue. Placement of a provisional restoration following implant surgery can create soft tissue contours that resemble normal gingival topography before placement of the definitive prosthesis. This article describes a staged approach of the mandibular permanent right central incisor, which was congenital missing. The proper space for restoration of the missing incisor was created through or...

  20. Provisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development

    OpenAIRE

    Wolk O; Agbaria R; Dahan A

    2014-01-01

    Omri Wolk, Riad Agbaria, Arik Dahan Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel Abstract: The main objective of this work was to investigate in-silico predictions of physicochemical properties, in order to guide oral drug development by provisional biopharmaceutics classification system (BCS). Four in-silico methods were used to estimate LogP: group contribution (CLogP) using two different softwa...

  1. Examining the provisional guidelines for weight gain in twin pregnancies: a retrospective cohort study

    OpenAIRE

    Lutsiv, Olha; Hulman, Adam; Woolcott, Christy; Beyene, Joseph; Giglia, Lucy; Armson, B. Anthony; Dodds, Linda; Neupane, Binod; McDonald, Sarah D

    2017-01-01

    Background Weight gain during pregnancy has an important impact on maternal and neonatal health. Unlike the Institute of Medicine (IOM) recommendations for weight gain in singleton pregnancies, those for twin gestations are termed “provisional”, as they are based on limited data. The objectives of this study were to determine the neonatal and maternal outcomes associated with gaining weight below, within and above the IOM provisional guidelines on gestational weight gain in twin pregnancies, ...

  2. The American Volunteer Soldier: Will He Fight. (A Provisional Attitudinal Analysis)

    Science.gov (United States)

    1975-06-02

    NUMBER 4. TITLE (end Subtitlm) THE AMERICAN VOLUNTEER SOLDIER: WILL HE FIGHT? (A PROVISIONAL ATTITUDINAL ANALYSIS) 5. TYPE OF REPORT A PERIOD... Psychologycal Solutions to Social Problems; An Introduction to Social Technology. New York: Academic Press, 1971. Walton, George, COL, USA (Ret...QUESTIONNAIRE. There are several types of questions in this questionnaire. EXAMPLES of the types you will encounter are listed below: FILL IN: [EXAMPLE

  3. Influence of immediate loading on provisional restoration in dental implant stability

    Science.gov (United States)

    Ikbal, M.; Odang, R. W.; Indrasari, M.; Dewi, R. S.

    2017-08-01

    The success of dental implant treatment is determined by the primary stability at placement. One factor that could influence this stability is occlusal loading through provisional restoration. Two types of loading protocols are usually used: immediate and delayed loading. However, some controversies remain about the influence of occlusal loading on implant stability. Therefore, the influence of immediate loading on implant stability must be studied. An animal study was conducted by placing nine dental implants in the mandibular jaw of three Macaca fascicularis. Provisional restorations with various occlusal contacts (no, light, and normal contact) were placed on the implant. The implant stability was measured using the Ostell ISQ three times: immediately (baseline) and at the first and second months after implant placement. The implant stability between implants with no and normal occlusal contact as well as light and normal occlusal contact showed significant differences (p implant placement. However, no significant increase (p > 0.05) in implant stability was seen at the baseline and the first and second months after implant placement for all occlusal contact groups. Immediate loading influenced the implant stability, and provisional restoration of implant without occlusal contact showed the highest implant stability.

  4. Towards Tolerance

    NARCIS (Netherlands)

    Lisette Kuyper; Jurjen Iedema; Saskia Keuzenkamp

    2013-01-01

    Across Europe, public attitudes towards lesbian, gay and bisexual (LGB) individuals range from broad tolerance to widespread rejection. Attitudes towards homosexuality are more than mere individual opinions, but form part of the social and political structures which foster or hinder the equality

  5. Repressive Tolerance

    DEFF Research Database (Denmark)

    Pedersen, Morten Jarlbæk

    2017-01-01

    to an administrative culture of repressive tolerance of organised interests: authorities listen but only reacts in a very limited sense. This bears in it the risk of jeopardising the knowledge transfer from societal actors to administrative ditto thus harming the consultation institutions’ potential for strengthening...

  6. Tolerance Geometry.

    Science.gov (United States)

    Roberts, Fred S.

    The author cites work on visual perception which indicates that in order to study perception it is necessary to replace such classical geometrical notions as betweeness, straightness, perpendicularity, and parallelism with more general concepts. The term tolerance geometry is used for any geometry when primitive notions are obtained from the…

  7. Comparison of the color stability of provisional restorative materials after storing in different drinks

    Directory of Open Access Journals (Sweden)

    Merve Bankoğlu Güngör

    2016-05-01

    Full Text Available OBJECTIVE: The objective of the present study was to compare the color stability of provisional restorative materials after stroring in different drinks. MATERIALS AND METHOD: Thirty specimens (10 mm in diameter and 2 mm in thickness were prepared from three different materials (Temdent, TRIAD ve TelioCAD. Specimens were divided into six groups according to drinks (distilled water, coffee, tea, cola, red wine and fruit juice; n=5. Specimens were stored in these drinks at 37 °C for 48 hours. The L*, a*, b* values of the specimens were measured with a spectrophometer and recorded before and after storing in drinks. Then ΔE* values were calculated. The data were statistically analyzed using two-way analysis of variance (ANOVA and Tukey’s HSD post hoc tests (α=0.05. RESULTS: Difference between the ΔE* values of specimens stored in different drinks was statistically significant (p<0.05. Color change of TelioCAD specimens was smallest in cola drink and greatest in red wine. Color change of Temdent specimens was smallest in fruit juice and greatest in coffee. For TRIAD specimens, greater color change was observed in coffee, red wine, and tea, in descending order. When the results of storing in the same drink were compared, TRIAD showed the greatest values of color change in coffee and red wine in comparison to the other provisional materials (p<0.05. CONCLUSION: Color stability changed according to the type of the provisional material and the drink. When the drinks were evaluated, greater color changes were observed in coffee, and when the materials were evaluated greater color changes were observed in TRIAD.

  8. Use of intraoral welding to stabilize dental implants in augmented sites for immediate provisionalization: a case report.

    Science.gov (United States)

    Avvanzo, Pierluigi; Fabrocini, Lelio A; Ciavarella, Domenico; Avvanzo, Andrea; Lo Muzio, Lorenzo; De Maio, Raffaele A

    2012-02-01

    Immediate implant rehabilitation of edentulous arches may be somewhat problematic because of anatomic situations involving insufficient bone thickness or height and tooth position. The aim of this report was to present a retrospective case series of dental implants placed into augmented sites (split crest or sinus augmentation) that were stabilized with an intraorally welded framework at the time of immediate provisionalization. An intraoral welding unit was used to join and stabilize implants as an orthopedic splint to break down forces applied on provisional restorations during healing and osseointegration. This approach allows for the immediate provisionalization of implants in bone-defective areas where multiple implant systems have been enacted. Forty-eight implants in 16 patients were inserted, welded together to a titanium framework, and immediately provisionalized during the same surgery in which split-crest or sinus augmentation procedures were performed. After removing the welded frameworks, 1 of 48 implants failed; the failed implant was associated with a sinus augmentation procedure. Intraoral welding stabilization may be a predictable procedure to allow immediate loading in augmented areas during healing time and to stabilize implants against nonaxial forces, thereby reducing the number of surgical and prosthetic sessions and making patients comfortable and accustomed to immediate fixed provisional and definitive restorations.

  9. Effect of different provisional cement remnant cleaning procedures including Er:YAG laser on shear bond strength of ceramics.

    Science.gov (United States)

    Zortuk, Mustafa; Gumus, Hasan Onder; Kilinc, Halil Ibrahim; Tuncdemir, Ali Riza

    2012-11-01

    The purpose of this study was to evaluate the effect of provisional cement removal by different dentin cleaning protocols (dental explorer, pumice, cleaning bur, Er:YAG laser) on the shear bond strength between ceramic and dentin. In total, 36 caries-free unrestored human third molars were selected as tooth specimens. Provisional restorations were fabricated and cemented with eugenol-free provisional cement. Then, disc-shaped ceramic specimens were fabricated and randomly assigned to four groups of dentin cleaning protocols (n = 9). Group 1 (control): Provisional cements were mechanically removed with a dental explorer. Group 2: The dentin surfaces were treated with a cleaning brush with pumice Group 3: The dentin surfaces were treated with a cleaning bur. Group 4: The provisional cements were removed by an Er:YAG laser. Self-adhesive luting cement was used to bond ceramic discs to dentin surfaces. Shear bond strength (SBS) was measured using a universal testing machine at a 0.05 mm/min crosshead speed. The data were analyzed using a Kolmogorov Smirnov, One-way ANOVA and Tukey HSD tests to perform multiple comparisons (α=0.05). THE DENTIN CLEANING METHODS DID NOT SIGNIFICANTLY AFFECT THE SBS OF CERAMIC DISCS TO DENTIN AS FOLLOWS: dental explorer, pumice, cleaning bur, and Er:YAG laser. The use of different cleaning protocols did not affect the SBS between dentin and ceramic surfaces.

  10. Effect of different provisional cement remnant cleaning procedures including Er:YAG laser on shear bond strength of ceramics

    Science.gov (United States)

    Zortuk, Mustafa; Gumus, Hasan Onder; Kilinc, Halil Ibrahim

    2012-01-01

    PURPOSE The purpose of this study was to evaluate the effect of provisional cement removal by different dentin cleaning protocols (dental explorer, pumice, cleaning bur, Er:YAG laser) on the shear bond strength between ceramic and dentin. MATERIALS AND METHODS In total, 36 caries-free unrestored human third molars were selected as tooth specimens. Provisional restorations were fabricated and cemented with eugenol-free provisional cement. Then, disc-shaped ceramic specimens were fabricated and randomly assigned to four groups of dentin cleaning protocols (n = 9). Group 1 (control): Provisional cements were mechanically removed with a dental explorer. Group 2: The dentin surfaces were treated with a cleaning brush with pumice Group 3: The dentin surfaces were treated with a cleaning bur. Group 4: The provisional cements were removed by an Er:YAG laser. Self-adhesive luting cement was used to bond ceramic discs to dentin surfaces. Shear bond strength (SBS) was measured using a universal testing machine at a 0.05 mm/min crosshead speed. The data were analyzed using a Kolmogorov Smirnov, One-way ANOVA and Tukey HSD tests to perform multiple comparisons (α=0.05). RESULTS The dentin cleaning methods did not significantly affect the SBS of ceramic discs to dentin as follows: dental explorer, pumice, cleaning bur, and Er:YAG laser. CONCLUSION The use of different cleaning protocols did not affect the SBS between dentin and ceramic surfaces. PMID:23236570

  11. Freezing tolerance versus freezing susceptibility in the land snail Helix aspersa (Gastropoda: Helicidae).

    Science.gov (United States)

    Ansart, A; Vernon, P; Daguzan, J

    2001-01-01

    Freezing hardiness in ectotherms has often been separated into two categories, freezing tolerance and freezing susceptibility. But more complex classifications have also been proposed. Helix aspersa hibernates in Brittany during winter. It has a high temperature of crystallisation (between -1.2( and -7.4 degrees C) and survives only few hours at freezing temperatures. Helix aspersa is a large snail, which needs a long time to freeze and can bear some ice formation in its tissues up to 60% of its total body water. It may be provisionally considered as a partially freezing tolerant species.

  12. Immediate implant placement and provisionalization with simultaneous guided bone regeneration in the esthetic zone

    Directory of Open Access Journals (Sweden)

    Chih-Long Chen

    2011-03-01

    Full Text Available The procedure for immediate implant placement and provisionalization is time-saving, possibly with only one surgical intervention required, although allowing maximal preservation of peri-implant tissues. In this case, we extracted a fractured maxillary right central incisor of a 46-year-old woman with high esthetic expectations, and a transmucosal implant was immediately installed. Simultaneous guided bone regeneration was performed to correct the defects at the facial side of the socket and augment the alveolar ridge horizontally. Primary stability of the implant body and wound closure without tension were confirmed. Connection of a 15° angled abutment and fabrication of a provisional acrylic resin crown without occlusal contact were also completed in the same appointment. After intensive follow-up and soft-tissue molding for 6 months, the customized zirconia abutment and all-ceramic crown were definitively fabricated. During the 18-month follow-up period, the patient was satisfied with the esthetic and functional results.

  13. The use of transitional implants to support provisional prostheses during the healing phase: a literature review.

    Science.gov (United States)

    de Almeida, Erika Oliveira; Filho, Homberto Gennari; Goiatto, Marcelo Coelho

    2011-01-01

    transitional implants are indicated for cases in which immediate loading is counterindicated because a healing period is necessary for osseointegration of the definitive implants. These provisional implants were developed to support an implant-supported fixed prosthesis or overdenture to provide retention, stability, and support. The aim of this article was to conduct a literature review on transitional implants to highlight the characteristics of the transitional implants and their advantages, indications, and contraindications, including the level of osseointegration of such implants according to the functional period. the present literature review was based on the Old Medline and Medline databases from 1999 to 2010 using the key words "transitional implants" and "temporary implants." Fourteen articles were found: 11 clinical studies or techniques and three histologic and histomorphometric studies. the transitional immediate prostheses were worn by completely and partially edentulous patients. Advantages of transitional implants include complete denture retention, stability, and support; maintenance of chewing, phonetics, and patient comfort; protection of bone grafts; vertical stop during healing period; easy and fast surgical and prosthetic procedures; lower cost in comparison to the definitive implant; and reestablishment of esthetics. The success of transitional implants as conservative treatment for conventional immediate loading is a reality if correctly indicated. transitional implants are a provisional treatment alternative for completely and partially edentulous patients. However, additional studies are required to evaluate the level of remodeling and repair of the transitional implants under loading.

  14. Evaluation of surface physical properties of acrylic resins for provisional prosthesis

    Directory of Open Access Journals (Sweden)

    Sérgio Paulo Hilgenberg

    2008-09-01

    Full Text Available Acrylic resins used for provisional prostheses should have satisfactory superficial characteristics in order to ensure gingival health and low bacterial attachment. The purpose of the present study was to evaluate the superficial roughness and contact angle after two types of polishing and the Vickers hardness of three acrylic resins (Duralay - G1, Dencrilay - G2, and Dencor - G3, all shade 66, indicated for provisional fixed prostheses. Five 20 x 3 ± 1 mm diameter discoid specimens were obtained for each group. One side of the specimens was subjected to standard polishing (pumice and whiting slurry, and the opposite side was polished with special tips. The mean roughness and contact angles of the materials were measured. The specimens were subjected to the Vickers microhardness test, which indicated that standard polishing produced a surface roughness equivalent to that of the special tips. The contact angles obtained with the standard polishing were equivalent to those observed in the special tips group. The microhardness of G1 and G3 resins showed statistical differences.

  15. A technique for indirect fabrication of a complete-arch, implant-supported, fixed provisional restoration from a radiographic template.

    Science.gov (United States)

    Spyropoulou, Panagiota-Eirini; Razzoog, Michael; Sierraalta, Marianella

    2010-09-01

    This article describes an alternative technique for the fabrication of a complete-arch, implant-supported, cement-retained, fixed provisional restoration. The definitive cast is fabricated from the surgical guide and the provisional restoration is fabricated indirectly from the radiographic guide. This technique is an easy and time-saving procedure to fabricate an interim prosthesis for immediate or delayed loading of implants. Copyright © 2010 The Editorial Council of the Journal of Prosthetic Dentistry. Published by Mosby, Inc. All rights reserved.

  16. Single ion heat engine with maximum efficiency at maximum power

    OpenAIRE

    Abah, Obinna; Rossnagel, Johannes; Jacob, Georg; Deffner, Sebastian; Schmidt-Kaler, Ferdinand; Singer, Kilian; Lutz, Eric

    2012-01-01

    We propose an experimental scheme to realize a nano heat engine with a single ion. An Otto cycle may be implemented by confining the ion in a linear Paul trap with tapered geometry and coupling it to engineered laser reservoirs. The quantum efficiency at maximum power is analytically determined in various regimes. Moreover, Monte Carlo simulations of the engine are performed that demonstrate its feasibility and its ability to operate at maximum efficiency of 30% under realistic conditions.

  17. 78 FR 3883 - The Bon-Ton Stores, Inc., Provisional Acceptance of a Settlement Agreement and Order

    Science.gov (United States)

    2013-01-17

    ... drawstrings (Garments) to consumers. The Garments were sold at retail stores in the United States for between... COMMISSION The Bon-Ton Stores, Inc., Provisional Acceptance of a Settlement Agreement and Order AGENCY... Agreement with The Bon-Ton Stores, Inc., containing a civil penalty of $450,000.00, within twenty (20) days...

  18. Innovative approach to computer-guided surgery and fixed provisionalization assisted by screw-retained transitional implants.

    Science.gov (United States)

    Gallucci, German O; Finelle, Gary; Papadimitriou, Dimitrios E V; Lee, Sang J

    2015-01-01

    The objectives of this case series are to describe a novel clinical approach to treat completely edentulous patients and determine its viability. Computer-guided implant planning was used to create a screw-retained surgical template (ST) supported by transitional implants and a fixed screw-retained provisional prosthesis supported by the transitional implants at the time of definitive implant placement. Five patients with at least one edentulous arch were treated. After the diagnostic tooth setup was performed, a duplicate with radiopaque acrylic resin was fabricated to serve as a surgical template (ST) for the placement of screw-form transitional implants and a radiographic guide (RG). Four transitional implants were strategically placed through the guide where they would not interfere with the future definitive implants. The transitional implants were used to support the RG during computed tomographic scanning. Subsequently, the RG was converted into a second ST based on three-dimensional virtual planning. Eight implants were placed by the computer-guided system, and an immediate prefabricated fixed provisional was connected to the transitional implants. All the implants included in the study achieved primary stability and osseointegrated successfully. For 4 months, the transitional implants served successfully as abutments for the provisional prosthesis. This innovative clinical approach overcomes the limitations of a mucosa/bone-supported ST by offering fixed, reproducible support for the RG and ST by means of transitional implants. The delivery of a prefabricated screw-retained provisional on transitional implants allows for passive healing and minimum chairside adjustments.

  19. 76 FR 77981 - Build-A-Bear Workshop, Inc., Provisional Acceptance of a Settlement Agreement and Order

    Science.gov (United States)

    2011-12-15

    ... COMMISSION Build-A-Bear Workshop, Inc., Provisional Acceptance of a Settlement Agreement and Order AGENCY... Agreement with Build-A-Bear Workshop, Inc., containing a civil penalty of $600,000.00. DATES: Any interested... Agreement 1. In accordance with 16 CFR 1118.20, Build-A-Bear Workshop, Inc. (``Build-A-Bear'') and staff of...

  20. Immediate loading versus immediate provisionalization of maxillary single-tooth replacements: a prospective randomized study with BioComp implants

    NARCIS (Netherlands)

    Lindeboom, Jerome A.; Frenken, Joost W.; Dubois, Leander; Frank, Michael; Abbink, Ingmar; Kroon, Frans H.

    2006-01-01

    PURPOSE: The aim of this prospective randomized study was to evaluate the clinical outcome of immediately loaded solid plasma sprayed (TPS) BioComp (BioComp Industries BV, Vught, The Netherlands) implants versus immediate provisionalized but non-loaded BioComp implants in the anterior and premolar

  1. Investigation on the hematopoietic effect of functional foods using radiation and preparing the provisional product

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Ho; Oh, Heon; Lee, Song Eun; Jeong, Yong Woon [Chonnam National University, Kwangju (Korea)

    1999-04-01

    We performed this study to determine the effect of several oriental prescriptions as energy tonic (Chinese medical concept: Bu-Qi) or blood building (Chinese medical concept: Bu-Xie) decoction and its major ingredients on jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells of mice irradiated with high and low dose of gamma-irradiation. For the study of evaluation on the biological stability of irradiated chinese medical prescriptions, we performed the experiment to determine the effect of irradiated (10kGy) or unirradiated Si-Wu-Tang, Bu-Zhong-Yi-Qi-Tang and San-Ling-Bai-Shu-San in irradiated mice. Further studies are needed to characterize better the protective nature of the total extract and its ingredients and for preparing the provisional product. (author). 61 refs., 3 figs., 21 tabs.

  2. Retentive force of O-ring attachment to use Immediate Provisional Implant (IPI)-retained overdenture.

    Science.gov (United States)

    Kobayashi, Mariko; Ohkubo, Chikahiro; Suzuki, Yasunori; Aoki, Takayuki; Sato, Jun-ichi; Hosoi, Toshio

    2005-12-01

    This study evaluated the retentive force of the O-ring attachment to an Immediate Provisional Implant (IPI)-retained overdenture. Two sizes of O-rings (#1, #2) were placed on the IPI abutment head. As the controls, soft relining material, silicone lining material, and the PMMA resin were used to connect the IPI abutment head. The retentive forces (n=5, N) obtained at a crosshead speed of 40 mm/min were analyzed by ANOVA/Tukey's HSD test (alpha=0.05). O-ring #1 showed the significantly greatest force among all materials tested (p0.05). Appropriate retention was obtained using the smaller O-ring#1 for the IPI-retained overdenture.

  3. Upper lower Cambrian (provisional Cambrian Series 2 trilobites from northwestern Gansu Province, China

    Directory of Open Access Journals (Sweden)

    Jan Bergström†

    2014-08-01

    Full Text Available Upper lower Cambrian (provisional Cambrian Series 2 trilobites are described from three sections through the Shuangyingshan Formation in the Beishan area, northwestern Gansu Province, China. The trilobite fauna is dominated by eodiscoid and corynexochid trilobites, together representing at least ten genera: Serrodiscus, Tannudiscus, Calodiscus, Pagetides, Kootenia, Edelsteinaspis, Ptarmiganoides?, Politinella, Dinesus and Subeia. Eleven species are described, of which seven are identified with previously described taxa and four described under open nomenclature. The composition of the fauna suggests biogeographic affinity with Siberian rather than Gondwanan trilobite faunas, and the Cambrian Series 2 faunas described herein and from elsewhere in northwestern China seem to be indicative of the marginal areas of the Siberian palaeocontinent. This suggests that the Middle Tianshan–Beishan Terrane may have been located fairly close to Siberia during middle–late Cambrian Epoch 2.

  4. Pre-surgical Provisional Prosthesis for Immediate Non-occlusal-loaded Flapless Implant.

    Science.gov (United States)

    Inbarajan, Athiban; Banu, Fathima; Tv, Padmanabhan; Kumar, Anand; Seenivasan, Madhan

    2017-06-13

    A 49-year-old patient reported for immediate replacement of missing maxillary anterior teeth with implant-retained prosthesis. Elevation of flap alters the mucosal level, causes discomfort, and delays the restorative procedure. To maintain the esthetics, flapless surgery was planned. Since placement of an implant is pre-planned in a predetermined site, fabrication of the prostheses before commencement of the surgery, especially when replacing the teeth in the anterior region, could be a viable option. This case report explains the method of fabrication of the provisional restoration for flapless surgery in the presurgical phase. The technique would avoid any micromotion and implant instability caused due to abutment preparation and impression procedure postsurgically.

  5. Emergency department external fixation for provisional treatment of pilon and unstable ankle fractures

    Directory of Open Access Journals (Sweden)

    Craig R Lareau

    2015-01-01

    Full Text Available Unstable ankle fractures and impacted tibial pilon fractures often benefit from provisional external fixation as a temporizing measure prior to definitive fixation. Benefits of external fixation include improved articular alignment, decreased articular impaction, and soft tissue rest. Uniplanar external fixator placement in the Emergency Department (ED ex-fix is a reliable and safe technique for achieving ankle reduction and stability while awaiting definitive fixation. This procedure involves placing transverse proximal tibial and calcaneal traction pins and connecting the pins with two external fixator rods. This technique is particularly useful in austere environments or when the operating room is not immediately available. Additionally, this bedside intervention prevents the patient from requiring general anesthesia and may be a cost-effective strategy for decreasing valuable operating time. The ED ex-fix is an especially valuable procedure in busy trauma centers and during mass casualty events, in which resources may be limited.

  6. Pre-prosthetic minor tooth movement with elastic separating ring & provisional restoration modification: case report

    Directory of Open Access Journals (Sweden)

    Haneol Shin

    2012-05-01

    Full Text Available Proximal caries or coronal defect in posterior teeth may result in the loss of proximal space and drifting of neighboring teeth, which makes restoration difficult. Inability to restore proper contours and to align tooth axis properly are commonly encountered problems when planning tooth restoration. Moreover, tilted teeth aggravate periodontal tissue breakdown, such as pseudo-pocket, and angular osseous defect. The purpose of this case presentation is to describe a simple technique for inducing minor tooth movement with orthodontic separating ring and provisional restoration modification. This method was used to create crown placement space on mesially tilted molar. This method is easy, simple and efficient technique which could be used in interproximal space gaining in selected situation.

  7. Principles of maximum entropy and maximum caliber in statistical physics

    Science.gov (United States)

    Pressé, Steve; Ghosh, Kingshuk; Lee, Julian; Dill, Ken A.

    2013-07-01

    The variational principles called maximum entropy (MaxEnt) and maximum caliber (MaxCal) are reviewed. MaxEnt originated in the statistical physics of Boltzmann and Gibbs, as a theoretical tool for predicting the equilibrium states of thermal systems. Later, entropy maximization was also applied to matters of information, signal transmission, and image reconstruction. Recently, since the work of Shore and Johnson, MaxEnt has been regarded as a principle that is broader than either physics or information alone. MaxEnt is a procedure that ensures that inferences drawn from stochastic data satisfy basic self-consistency requirements. The different historical justifications for the entropy S=-∑ipilog⁡pi and its corresponding variational principles are reviewed. As an illustration of the broadening purview of maximum entropy principles, maximum caliber, which is path entropy maximization applied to the trajectories of dynamical systems, is also reviewed. Examples are given in which maximum caliber is used to interpret dynamical fluctuations in biology and on the nanoscale, in single-molecule and few-particle systems such as molecular motors, chemical reactions, biological feedback circuits, and diffusion in microfluidics devices.

  8. Workplace exposure to nanoparticles and the application of provisional nanoreference values in times of uncertain risks

    Science.gov (United States)

    van Broekhuizen, Pieter; van Broekhuizen, Fleur; Cornelissen, Ralf; Reijnders, Lucas

    2012-03-01

    Nano reference values (NRVs) for occupational use of nanomaterials were tested as provisional substitute for Occupational Exposure Limits (OELs). NRVs can be used as provisional limit values until Health-Based OELs or derived no-effect levels (DNEL) become available. NRVs were defined for 8 h periods (time weighted average) and for short-term exposure periods (15 min-time weighted average). To assess the usefulness of these NRVs, airborne number concentrations of nanoparticles (NPs) in the workplace environment were measured during paint manufacturing, electroplating, light equipment manufacturing, non-reflective glass production, production of pigment concentrates and car refinishing. Activities monitored were handling of solid engineered NPs (ENP), abrasion, spraying and heating during occupational use of nanomaterials (containing ENPs) and machining nanosurfaces. The measured concentrations are often presumed to contain ENPs as well as process-generated NPs (PGNP). The PGNP are found to be a significant source for potential exposure and cannot be ignored in risk assessment. Levels of NPs identified in workplace air were up to several millions of nanoparticles/cm3. Conventional components in paint manufacturing like CaCO3 and talc may contain a substantial amount of nanosized particulates giving rise to airborne nanoparticle concentrations. It is argued that risk assessments carried out for e.g. paint manufacturing processes using conventional non-nano components should take into account potential nanoparticle emissions as well. The concentrations measured were compared with particle-based NRVs and with mass-based values that have also been proposed for workers protection. It is concluded that NRVs can be used for risk management for handling or processing of nanomaterials at workplaces provided that the scope of NRVs is not limited to ENPs only, but extended to the exposure to process-generated NPs as well.

  9. Analysis of colour stability of selected provisional prosthetic materials: an in vitro study.

    Science.gov (United States)

    Koczorowski, Ryszard; Linkowska-Swidzińska, Kamila; Gedrange, Tomasz; Swidziński, Teodor

    2009-08-01

    Prosthetic restorative materials (that are) used for temporary fixed dentures tend to exhibit variable discolouration over several weeks of use. The aim of this study was to perform a spectrophotometric analysis of the influence of selected discolouring factors on the colour stability of provisional prosthetic materials in vitro. In the study, the following prosthetic materials for short-term use in the oral cavity were evaluated: Luxatemp, Structur 2S.C., Protemp II, Zhermacryl STC and Dentalon Plus. Samples of these materials were immersed in coffee, tea and dark fruit juice for 60 h at different pH values. Colour was evaluated by determining the monochromatic coefficients of light reflected by the samples, using a spectrophotometric method. Results received in artificial light (illuminant A) were compared with those obtained in daylight (illuminant D65). Changes in colour and its parameters according to the CIE L*a*b* system were analysed. The analysis (of the colour and colour parameters) of the tested materials in two types of light showed that Structur displayed the greatest tendency to discolouration and that the least tendency to discolouration was exhibited by Dentalon Plus. The fact that colour parameters obtained in two types of light were not identical suggests that changes in the colour of the same material may be perceived differently, depending on the illuminant. Provisional prosthetic materials show variable colour stability under different conditions in the oral cavity. The colour of prosthetic materials may be perceived differently, depending on the illuminant and the effect of the environment in which they are used.

  10. In Vitro Fit and Cementation Resistance of Provisional Crowns for Single Implant-Supported Restorations.

    Science.gov (United States)

    Moris, Izabela Cristina Maurício; Oliveira, Juliana Elias de; Faria, Adriana Cláudia Lapria; Ribeiro, Ricardo Faria; Rodrigues, Renata Cristina Silveira

    2015-10-01

    This study aimed to verify marginal fit and the effect of cement film thickness standardization on retention of provisional crowns made with prefabricated acrylic cylinders on abutments, using two temporary luting agents subjected or not to mechanical cycling. Provisional crowns were made from bis-acryl (Luxatemp Fluorescence) or methyl methacrylate (Duralay) resins on acrylic cylinders and marginal fit and cement film thickness were evaluated. For retention evaluation, crowns were cemented with two temporary luting agents: non-eugenol zinc oxide (Tempbond NE) or calcium hydroxide-based (Hydcal) cements and subjected to tensile strength in a universal testing machine. After cleaning, debonded crowns were cemented again, subjected to mechanical cycling and retention was reassessed. The results of marginal fit and cement film thickness were analyzed by Student's t-test while retention of cements before and after mechanical cycling was analyzed using a mixed linear model. Methyl methacrylate crowns presented greater marginal misfit (p=0.001) and occlusal cement film thickness (p=0.003) than the bis-acryl ones. No difference was observed at axial cement film thickness (p=0.606). Resins (p=0.281) did not affect crown retention, but luting agents (p=0.029) and mechanical cycling (p=0.027) showed significant effects. The only significant interaction was mechanical cycling*luting agents, which means that luting agents were differently affected by mechanical cycling (p=0.002). In conclusion, the results showed that bis-acryl resin associated to calcium-hydroxide luting agent provided the best retention and lower cement thickness.

  11. Agitation in cognitive disorders: International Psychogeriatric Association provisional consensus clinical and research definition.

    Science.gov (United States)

    Cummings, Jeffrey; Mintzer, Jacobo; Brodaty, Henry; Sano, Mary; Banerjee, Sube; Devanand, D P; Gauthier, Serge; Howard, Robert; Lanctôt, Krista; Lyketsos, Constantine G; Peskind, Elaine; Porsteinsson, Anton P; Reich, Edgardo; Sampaio, Cristina; Steffens, David; Wortmann, Marc; Zhong, Kate

    2015-01-01

    Agitation is common across neuropsychiatric disorders and contributes to disability, institutionalization, and diminished quality of life for patients and their caregivers. There is no consensus definition of agitation and no widespread agreement on what elements should be included in the syndrome. The International Psychogeriatric Association formed an Agitation Definition Work Group (ADWG) to develop a provisional consensus definition of agitation in patients with cognitive disorders that can be applied in epidemiologic, non-interventional clinical, pharmacologic, non-pharmacologic interventional, and neurobiological studies. A consensus definition will facilitate communication and cross-study comparison and may have regulatory applications in drug development programs. The ADWG developed a transparent process using a combination of electronic, face-to-face, and survey-based strategies to develop a consensus based on agreement of a majority of participants. Nine-hundred twenty-eight respondents participated in the different phases of the process. Agitation was defined broadly as: (1) occurring in patients with a cognitive impairment or dementia syndrome; (2) exhibiting behavior consistent with emotional distress; (3) manifesting excessive motor activity, verbal aggression, or physical aggression; and (4) evidencing behaviors that cause excess disability and are not solely attributable to another disorder (psychiatric, medical, or substance-related). A majority of the respondents rated all surveyed elements of the definition as "strongly agree" or "somewhat agree" (68-88% across elements). A majority of the respondents agreed that the definition is appropriate for clinical and research applications. A provisional consensus definition of agitation has been developed. This definition can be used to advance interventional and non-interventional research of agitation in patients with cognitive impairment.

  12. ENUGU USING MAXIMUM TEMPERATURE DATA

    African Journals Online (AJOL)

    2008-01-28

    Jan 28, 2008 ... daily global solar radiation on a horizontal surface for some towns in Nigeria. For example, Sanusi and Aliyu (2005) used maximum temperature data to predict for. Sokoto. lheonu (2001) did the same for lbadan. Badmus and Momoh(2005) did likewise for Birnin Kebbi. So did Awachie and Okeke(1 990) for ...

  13. Maximum stellar iron core mass

    Indian Academy of Sciences (India)

    Abstract. An analytical method of estimating the mass of a stellar iron core, just prior to core collapse, is .... approximately as an ideal gas, the mean kinetic energies of the free electrons and atomic nuclei will be equal. .... whose density varies from a maximum at the core's center to a minimum at its 'surface'. The dimensional ...

  14. Abolishing the maximum tension principle

    Directory of Open Access Journals (Sweden)

    Mariusz P. Da̧browski

    2015-09-01

    Full Text Available We find the series of example theories for which the relativistic limit of maximum tension Fmax=c4/4G represented by the entropic force can be abolished. Among them the varying constants theories, some generalized entropy models applied both for cosmological and black hole horizons as well as some generalized uncertainty principle models.

  15. maXImum medical aid

    African Journals Online (AJOL)

    1990-08-04

    Aug 4, 1990 ... the passage of time. S Afr Med J 1990; 78: 147-151. Medicine prices have increased significantly in recent years. Over the past 5 years, the medicines price .... Maximum. "- dispensed. No. in. Approved price before. Product list name. Strength. Form. Pack prof. fee (R) examples. Allopurinol. 100 mg. Tablets.

  16. A cross-validation of the provisional diagnostic instrument (PDI-4

    Directory of Open Access Journals (Sweden)

    Faries Douglas E

    2012-10-01

    Full Text Available Abstract Background The Provisional Diagnostic Instrument (PDI-4 is a brief, adult self-report instrument for 4 common psychiatric diagnoses in primary care patients: major depressive episode (MDE, generalized anxiety disorder (GAD, attention deficit hyperactivity disorder (ADHD, and bipolar I disorder based on past or present mania. Our objective was to assess validity of the PDI-4 in a population independent of the study population originally used to develop the scale. Methods An online version of the 17-item PDI-4 was administered to 1,047 adults in the US; respondents also completed the PHQ-9, HADS-A, CAARS-S, and MDQ within the online survey. Respondents self-reported diagnosis by a healthcare professional with the terms depression (n=221, anxiety (n=218, attention deficit disorder (n=206, bipolar or manic depressive disorder (n=195, or none of these (n=207. Statistical analyses examined convergent and discriminant validity, and operating characteristics of the PDI-4 relative to the individual, validated, self-rated scales PHQ-9, HADS-A, CAARS-S, and MDQ, for each PDI-4 diagnosis. Results Convergent validity of the PDI-4 was supported by strong correlations with the corresponding individual scales (range of 0.63 [PDI-4 and MDQ] to 0.87 [PDI-4 and PHQ-9]. Operating characteristics of the PDI-4 were similar to results in the previous site-based study. The scale exhibited moderate sensitivities (0.52 [mania] to 0.70 [ADHD] and strong specificities (0.86 [mania] to 0.92 [GAD] using the individual scales as the gold standards. ANOVAs demonstrated that PDI-4 discriminated between subsets of patients defined by pre-specified severity level cutoff scores of the individual scales. However, overlapping symptoms and co-morbidities made differentiation between mental diagnoses much weaker than differentiation from the control group with none of the diagnoses. Conclusions The PDI-4 appears to be a suitable, brief, self-rated tool for provisional

  17. Physiologically-based pharmacokinetic model for Fentanyl in support of the development of Provisional Advisory Levels

    Energy Technology Data Exchange (ETDEWEB)

    Shankaran, Harish, E-mail: harish.shankaran@pnnl.gov [Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA 99352 (United States); Adeshina, Femi [National Homeland Security Research Center, United States Environmental Protection Agency, Washington, DC 20460 (United States); Teeguarden, Justin G. [Systems Toxicology Group, Pacific Northwest National Laboratory, Richland, WA 99352 (United States)

    2013-12-15

    Provisional Advisory Levels (PALs) are tiered exposure limits for toxic chemicals in air and drinking water that are developed to assist in emergency responses. Physiologically-based pharmacokinetic (PBPK) modeling can support this process by enabling extrapolations across doses, and exposure routes, thereby addressing gaps in the available toxicity data. Here, we describe the development of a PBPK model for Fentanyl – a synthetic opioid used clinically for pain management – to support the establishment of PALs. Starting from an existing model for intravenous Fentanyl, we first optimized distribution and clearance parameters using several additional IV datasets. We then calibrated the model using pharmacokinetic data for various formulations, and determined the absorbed fraction, F, and time taken for the absorbed amount to reach 90% of its final value, t90. For aerosolized pulmonary Fentanyl, F = 1 and t90 < 1 min indicating complete and rapid absorption. The F value ranged from 0.35 to 0.74 for oral and various transmucosal routes. Oral Fentanyl was absorbed the slowest (t90 ∼ 300 min); the absorption of intranasal Fentanyl was relatively rapid (t90 ∼ 20–40 min); and the various oral transmucosal routes had intermediate absorption rates (t90 ∼ 160–300 min). Based on these results, for inhalation exposures, we assumed that all of the Fentanyl inhaled from the air during each breath directly, and instantaneously enters the arterial circulation. We present model predictions of Fentanyl blood concentrations in oral and inhalation scenarios relevant for PAL development, and provide an analytical expression that can be used to extrapolate between oral and inhalation routes for the derivation of PALs. - Highlights: • We develop a Fentanyl PBPK model for relating external dose to internal levels. • We calibrate the model to oral and inhalation exposures using > 50 human datasets. • Model predictions are in good agreement with the available

  18. Examining the provisional guidelines for weight gain in twin pregnancies: a retrospective cohort study.

    Science.gov (United States)

    Lutsiv, Olha; Hulman, Adam; Woolcott, Christy; Beyene, Joseph; Giglia, Lucy; Armson, B Anthony; Dodds, Linda; Neupane, Binod; McDonald, Sarah D

    2017-09-29

    Weight gain during pregnancy has an important impact on maternal and neonatal health. Unlike the Institute of Medicine (IOM) recommendations for weight gain in singleton pregnancies, those for twin gestations are termed "provisional", as they are based on limited data. The objectives of this study were to determine the neonatal and maternal outcomes associated with gaining weight below, within and above the IOM provisional guidelines on gestational weight gain in twin pregnancies, and additionally, to explore ranges of gestational weight gain among women who delivered twins at the recommended gestational age and birth weight, and those who did not. A retrospective cohort study of women who gave birth to twins at ≥20 weeks gestation, with a birth weight ≥ 500 g was conducted in Nova Scotia, Canada (2003-2014). Our primary outcome of interest was small for gestational age (<10th percentile). In order to account for gestational age at delivery, weekly rates of 2nd and 3rd trimester weight gain were used to categorize women as gaining below, within, or above guidelines. We performed traditional regression analyses for maternal outcomes, and to account for the correlated nature of the neonatal outcomes in twins, we used generalized estimating equations (GEE). A total of 1482 twins and 741 mothers were included, of whom 27%, 43%, and 30% gained below, within, and above guidelines, respectively. The incidence of small for gestational age in these three groups was 30%, 21%, and 20%, respectively, and relative to gaining within guidelines, the adjusted odds ratios were 1.44 (95% CI 1.01-2.06) for gaining below and 0.92 (95% CI 0.62-1.36) for gaining above. The gestational weight gain in women who delivered twins at 37-42 weeks with average birth weight ≥ 2500 g and those who delivered twins outside of the recommend ranges were comparable to each other and the IOM recommendations. While gestational weight gain below guidelines for twins was associated with some

  19. Maximum Entropy Discrimination Markov Networks

    OpenAIRE

    Zhu, Jun; Xing, Eric P.

    2009-01-01

    In this paper, we present a novel and general framework called {\\it Maximum Entropy Discrimination Markov Networks} (MaxEnDNet), which integrates the max-margin structured learning and Bayesian-style estimation and combines and extends their merits. Major innovations of this model include: 1) It generalizes the extant Markov network prediction rule based on a point estimator of weights to a Bayesian-style estimator that integrates over a learned distribution of the weights. 2) It extends the ...

  20. Tolerance analysis and variational solid geometry

    Energy Technology Data Exchange (ETDEWEB)

    Watterberg, P. [Sandia National Labs., Albuquerque, NM (United States). Intelligent Systems and Robotics Center

    1998-01-01

    The fields of tolerancing and assembly analysis have depended for decades on ad hoc, shop floor methods. This causes serious problems when subjected toleranced designs to automated, analytical methods. This project attempted to further the formalization and mathematization of tolerancing by extending the concept of the Maximum Material Part. A software system was envisioned that would guide designers in the use of appropriate tolerance specifications and then create software models of Maximum Material Parts from the toleranced nominal parts.

  1. Multifactorial analysis of variables influencing the fracture strength of repair joints for provisional restorative materials using the statistically based Taguchi method

    Directory of Open Access Journals (Sweden)

    Chun-Jen Cheng

    2010-06-01

    Conclusion: Within the limitations of this study, these four design factors had different contributions to the fracture strength of repaired provisional restorations. Clinicians must be aware of the sequence of importance in determining better problem-solving methods.

  2. Effect of water temperature on the fit of provisional crown margins during polymerization: An in vitro study

    Science.gov (United States)

    Ramkumar, Vivekanandan; Sangeetha, Arunachalam; Kumar, Vinaya

    2012-01-01

    Aim: To evaluate the effect of water temperature on the marginal fit of bis-acrylic composite provisional crown during resin polymerization. Materials and Methods: Precisely machined 10 brass master dies were designed to simulate molar teeth. Five brass dies were selected and precisely machined to simulate all ceramic crown preparation. An acrylic jaw replica was made in which brass dies were arranged equidistant from each other. A custom-made metallic tray was fabricated on the acrylic jaw replica to make polyvinyl siloxane impression matrix. Bis-acrylic composite resin provisional crowns were made using polyvinyl siloxane impression matrix. Provisional crowns were polymerized at room temperature (Group I direct technique, on dental stone cast; Group I indirect technique crowns) and at different water temperatures (Group II direct technique crowns). The vertical marginal gap between all the provisional crown margins and the finish line of brass dies was measured using a Research Stereomicroscope System. Results: The results were statistically analyzed using one-way analysis of variance (ANOVA) test and Newman–Keul's test. The results showed that crowns polymerized in 20°C and 30°C water had marginal gap approximately three times smaller than those polymerized in 30°C air, due to the reduced polymerization shrinkage. Conclusion: This study shows that crowns polymerized in 20°C and 30°C water had mean vertical marginal gap approximately three times smaller than those polymerized in 30°C air. It was approximately closer to that of crowns fabricated by indirect technique. Warmer water also supposedly hastens polymerization. PMID:23066294

  3. Coronal leakage of provisional restorative materials used in endodontics with and without intracanal medication after exposure to human saliva

    Directory of Open Access Journals (Sweden)

    P Udayakumar

    2016-01-01

    Full Text Available Aim: To determine the coronal leakage of various provisional restorations with and without intracanal medication over time after being exposed to human saliva. Materials and Methods: This study investigated Coltosol F, Cavit, Ketac Molar, and IRM as provisional restorative material. Calcium hydroxide and chlorhexidine were used as an intracanal medicament. Ninety-eight single rooted teeth were randomly selected and then mounted in an apparatus that isolated the crown portion of the tooth. Provisional restorative materials were placed in the access cavity following manufacturer guidelines after placement of intracanal medicament. Human saliva and brain heart infusion broth in 3:1 ratio were applied to the samples, incubated at 37°C, and results were tabulated over the course of 4 weeks by the appearance of turbidity in the lower part of the apparatus. Statistical Analysis: The data were statistically analyzed using proportional Z-test. The level of significance was set at 0.05. Results: Coltosol F and Cavit could significantly prevent the bacterial leakage up to a period of 7 days with a P value of 0.01 and 0.005, respectively. Bacterial recontamination was relatively less in the samples treated with intracanal medicaments up to 14 days. After 14 days, however, all materials leaked in over half of the samples. Conclusion: No provisional restorative material can be considered superior in providing a reliable seal after 14 days. Inter-appointments schedule should not extend beyond 2 weeks and after endodontic therapy final restoration should be completed within 1 week.

  4. The Effect of Different Fiber Concentrations on the Surface Roughness of Provisional Crown and Fixed Partial Denture Resin

    OpenAIRE

    Zortuk, Mustafa; K?l?c, Kerem; Uzun, Gulay; Ozturk, Ahmet; Kesim, Bulent

    2008-01-01

    Objectives The aim of this study was to investigate surface roughness in provisional crown acrylics, after polishing, reinforced with different concentrations of glass fibers. Methods A total of 48 disk-shaped specimens were prepared using autopolymerizing acrylic resin. These specimens were divided into four groups according to the level of glass fiber added: Group A (no fiber), Group B (0.5%), Group C (1%) and Group D (2%). After polishing the specimens, an average surface roughness (Ra) va...

  5. Randomized comparison between provisional and routine kissing-balloon technique after main vessel crossover stenting for coronary bifurcation lesions.

    Science.gov (United States)

    Yamawaki, Masahiro; Fujita, Masaki; Sasaki, Shinya; Tsurugida, Masanori; Nanasato, Mamoru; Araki, Motoharu; Hirano, Keisuke; Ito, Yoshiaki; Tsukahara, Reiko; Muramatsu, Toshiya

    2017-04-11

    We compared the myocardial ischemic burden of provisional and routine final kissing-balloon inflation (FKI) with the 1-stent strategy using a second-generation drug-eluting stent for coronary bifurcation lesions (CBL). There are no established guidelines for side branch (SB) intervention after main vessel stenting. In total, 113 CBL patients were randomized to receive different SB intervention strategies: provisional-FKI group (n = 57; FKI only when SB flow was TIMI stress myocardial perfusion scintigraphy with (99m)Tc was performed after 8 months. The regional summed-difference score (r-SDS) was calculated according to the coronary territory. The primary endpoint included target vessel ischemia (TVI; r-SDS ≥ 2) at 8 months, whereas the clinical primary endpoint was major adverse cardiovascular events (MACE) at 3 years. The percent (%) myocardial ischemia (100 × SDS/68) was also calculated. At 8 months, TVI was identified in 11 and 4% in the provisional-FKI and routine-FKI groups, respectively (p = 0.226). SB-binary restenosis (48 vs. 4%, p 10% myocardial ischemia) was not observed in the target vessel in either group. Long-term cumulative MACE were similar between the groups (9 vs. 14%; p = 0.358). Provisional-FKI according to TIMI-SB flow grade led to similar and acceptable myocardial ischemia, in comparison with routine-FKI, which may contribute to the identical long-term follow-up.

  6. Effect of water temperature on the fit of provisional crown margins during polymerization: An in vitro study

    Directory of Open Access Journals (Sweden)

    Vivekanandan Ramkumar

    2012-01-01

    Full Text Available Aim: To evaluate the effect of water temperature on the marginal fit of bis-acrylic composite provisional crown during resin polymerization. Materials and Methods: Precisely machined 10 brass master dies were designed to simulate molar teeth. Five brass dies were selected and precisely machined to simulate all ceramic crown preparation. An acrylic jaw replica was made in which brass dies were arranged equidistant from each other. A custom-made metallic tray was fabricated on the acrylic jaw replica to make polyvinyl siloxane impression matrix. Bis-acrylic composite resin provisional crowns were made using polyvinyl siloxane impression matrix. Provisional crowns were polymerized at room temperature (Group I direct technique, on dental stone cast; Group I indirect technique crowns and at different water temperatures (Group II direct technique crowns. The vertical marginal gap between all the provisional crown margins and the finish line of brass dies was measured using a Research Stereomicroscope System. Results: The results were statistically analyzed using one-way analysis of variance (ANOVA test and Newman-Keul′s test. The results showed that crowns polymerized in 20°C and 30°C water had marginal gap approximately three times smaller than those polymerized in 30°C air, due to the reduced polymerization shrinkage. Conclusion: This study shows that crowns polymerized in 20°C and 30°C water had mean vertical marginal gap approximately three times smaller than those polymerized in 30°C air. It was approximately closer to that of crowns fabricated by indirect technique. Warmer water also supposedly hastens polymerization.

  7. Provisional Tic Disorder: What to tell parents when their child first starts ticcing

    Science.gov (United States)

    Black, Kevin J; Black, Elizabeth Rose; Greene, Deanna J.; Schlaggar, Bradley L.

    2016-01-01

    The child with recent onset of tics is a common patient in a pediatrics or child neurology practice. If the child’s first tic was less than a year in the past, the diagnosis is usually Provisional Tic Disorder (PTD). Published reviews by experts reveal substantial consensus on prognosis in this situation: the tics will almost always disappear in a few months, having remained mild while they lasted. Surprisingly, however, the sparse existing data may not support these opinions. PTD may have just as much importance for science as for clinical care. It provides an opportunity to prospectively observe the spontaneous remission of tics. Such prospective studies may aid identification of genes or biomarkers specifically associated with remission rather than onset of tics. A better understanding of tic remission may also suggest novel treatment strategies for Tourette syndrome, or may lead to secondary prevention of tic disorders. This review summarizes the limited existing data on the epidemiology, phenomenology, and outcome of PTD, highlights areas in which prospective study is sorely needed, and proposes that tic disorders may completely remit much less often than is generally believed. PMID:27158458

  8. Soft Tissue Augmentation Techniques in Implants Placed and Provisionalized Immediately: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Rosa Rojo

    2016-01-01

    Full Text Available The aim of this study was to evaluate the effectiveness of techniques for soft tissue augmentation in the placement of immediate implants with and without provisionalization and to assess the quality of the reports in the literature. Randomized clinical trials, prospective clinical trials, and case series were included in this review. Clinical questions were formulated and organised according to the PICOS strategy. An electronic search was performed in PubMed, Cochrane Central Register of Controlled Trials, Scopus, and ISI Web up until June 2016. Interexaminer agreement on eligibility (k=0.842; p=0.103 and quality (k=0.933; p<0.001 was high. Methodological approaches were assessed using criteria based on design related forms designed by the Dutch Cochrane Collaboration. Finally, 14 papers were identified. In two studies, the implant survival was 90%; for the rest of the studies it was 100%. All studies reported favourable aesthetic, biological, and radiographic outcomes. Surgical and biomechanical complications of this technique were not relevant. This technique effectively compensates for the expected loss of volume of the oral soft tissues and maintains high success rates with good aesthetic results over time.

  9. Provisional Matrix Deposition in Hemostasis and Venous Insufficiency: Tissue Preconditioning for Nonhealing Venous Ulcers

    Science.gov (United States)

    Parker, Tony J.; Broadbent, James A.; McGovern, Jacqui A.; Broszczak, Daniel A.; Parker, Christina N.; Upton, Zee

    2015-01-01

    Significance: Chronic wounds represent a major burden on global healthcare systems and reduce the quality of life of those affected. Significant advances have been made in our understanding of the biochemistry of wound healing progression. However, knowledge regarding the specific molecular processes influencing chronic wound formation and persistence remains limited. Recent Advances: Generally, healing of acute wounds begins with hemostasis and the deposition of a plasma-derived provisional matrix into the wound. The deposition of plasma matrix proteins is known to occur around the microvasculature of the lower limb as a result of venous insufficiency. This appears to alter limb cutaneous tissue physiology and consequently drives the tissue into a ‘preconditioned’ state that negatively influences the response to wounding. Critical Issues: Processes, such as oxygen and nutrient suppression, edema, inflammatory cell trapping/extravasation, diffuse inflammation, and tissue necrosis are thought to contribute to the advent of a chronic wound. Healing of the wound then becomes difficult in the context of an internally injured limb. Thus, interventions and therapies for promoting healing of the limb is a growing area of interest. For venous ulcers, treatment using compression bandaging encourages venous return and improves healing processes within the limb, critically however, once treatment concludes ulcers often reoccur. Future Directions: Improved understanding of the composition and role of pericapillary matrix deposits in facilitating internal limb injury and subsequent development of chronic wounds will be critical for informing and enhancing current best practice therapies and preventative action in the wound care field. PMID:25785239

  10. Canadian Federalism in Design and Practice: The Mechanics of a Permanently Provisional Constitution

    Directory of Open Access Journals (Sweden)

    Gardner James A.

    2017-12-01

    Full Text Available This paper examines the interaction between constitutional design and practice through a case study of Canadian federalism. Focusing on the federal architecture of the Canadian Constitution, the paper examines how subnational units in Canada actually compete with the central government, emphasizing the concrete strategies and tactics they most commonly employ to get their way in confrontations with central authority. The evidence affirms that constitutional design and structure make an important difference in the tactics and tools available to subnational units in a federal system, but that design is not fully constraining: there is considerable evidence of extraconstitutional innovation and improvisation by governments. Furthermore, changes in practice initiated by Canadian subnational actors have produced changes in the allocation of national and subnational authority that are plausibly characterized as constitutional in magnitude. The paper concludes that the design of the Canadian federal system may inadvertently undermine its capacity to stabilize itself at any particular point of constitutional evolution, making it ‘permanently provisional.’

  11. Soft Tissue Augmentation Techniques in Implants Placed and Provisionalized Immediately: A Systematic Review.

    Science.gov (United States)

    Rojo, Rosa; Prados-Frutos, Juan Carlos; Manchón, Ángel; Rodríguez-Molinero, Jesús; Sammartino, Gilberto; Calvo Guirado, José Luis; Gómez-de Diego, Rafael

    2016-01-01

    The aim of this study was to evaluate the effectiveness of techniques for soft tissue augmentation in the placement of immediate implants with and without provisionalization and to assess the quality of the reports in the literature. Randomized clinical trials, prospective clinical trials, and case series were included in this review. Clinical questions were formulated and organised according to the PICOS strategy. An electronic search was performed in PubMed, Cochrane Central Register of Controlled Trials, Scopus, and ISI Web up until June 2016. Interexaminer agreement on eligibility (k = 0.842; p = 0.103) and quality (k = 0.933; p < 0.001) was high. Methodological approaches were assessed using criteria based on design related forms designed by the Dutch Cochrane Collaboration. Finally, 14 papers were identified. In two studies, the implant survival was 90%; for the rest of the studies it was 100%. All studies reported favourable aesthetic, biological, and radiographic outcomes. Surgical and biomechanical complications of this technique were not relevant. This technique effectively compensates for the expected loss of volume of the oral soft tissues and maintains high success rates with good aesthetic results over time.

  12. ¿Cuánto cuesta el rescate bancario?: una estimación provisional

    Directory of Open Access Journals (Sweden)

    José Francisco Bellod Redondo

    2013-01-01

    Full Text Available en este trabajo presentamos una estimación provisional del importe de los recursos movilizados por las Administraciones Públicas en favor de los bancos españoles. Como el proceso de rescate bancario aún no ha finalizado y, como ciertos costes han de tener lugar en el futuro, la cuantificación es necesariamente incompleta. Según nuestras estimaciones los recursos inyectados ascienden a día de hoy a más de 126.000 millones de euros (11´9% del PIB, de los cuales más de 41.000 millones son irrecuperables. La venta de bancos a precios simbólicos ha sido una operación muy gravosa por la cual se han perdido 13.548 millones de euros. Aparte habría que computar los recursos procedentes del Banco Central Europeo (BCE, más de 340.000 millones de euros.

  13. Work and organisation in wood fuel systems. Provisional results from a pilot project

    Energy Technology Data Exchange (ETDEWEB)

    Ager, B. [Swedish Univ. of Agricultural Sciences, Dept. of Operational Efficiency, Garpenberg (Sweden); Soederqvist, A. [WE-Consulting AB, Tyresoe (Sweden)

    1996-12-31

    The use of wood fuels in Sweden has increased dramatically over the last few years. So far wood chips from tops and limbs and waste from the lumber/wood working industry have been the primary fuel sources. However, upgraded wood fuels, mainly in the shape of pellets, are rapidly gaining ground and used wood and short rotation forests are other sources under expansion. In the modern wood fuel sector new technology and production systems are being tested and introduced and new organisational structures and enterprises are developing. But rather few studies have been carried out concerning the conditions for the workers engaged in the production systems. An area which has attracted several studies is health hazards caused by various kinds of air pollutants, such as dust and moulds, but in most other areas knowledge is rather scarce. After a minor introductory study a comprehensive pilot project was formulated. The project is titled `Work and organisation in wood fuel systems` and will run from July 1996 to March 1998. The main objective of this project is to investigate working environment and work organisation in wood fuel systems in order to identify problems and ways of achieving improvement and development. This paper will discuss provisional results from studies of three selected production systems, which are especially common or expanding - harvest and transport of logging residues, production of wood pellets, and heating plants. (au)

  14. Redesign of a fixture mount to be used as an impression coping and a provisional abutment as well

    Directory of Open Access Journals (Sweden)

    Glenn Hsuan-Chen Chang

    2011-01-01

    Full Text Available Purpose: An integrated fixture mount/impression coping/ temporary abutment can provide many advantages for immediate loading of dental implants, such as simpler procedure, less chair time, cost reduction, and comfort for the patients. Materials and Methods: A newly designed dental implant fixture mount (DIFMA can be used as an impression coping for taking an immediate impression. An immediate load provisional prosthesis can then be fabricated shortly after implant placement to immediately load the implants. This fixture mount can also serve as a temporary abutment for immediate chair-side fabrication of provisional prosthesis. Two clinical cases are presented. Results: A clinical case utilizing the fixture mount abutment (DIFMA/implant assembly is presented. The precision of fitting between the impression copings and implants is secured with this system. The chair time for taking an immediate impression is greatly reduced. Less cost for the restoration is provided and patient comfort is delivered. Conclusions: More patient satisfaction can be conferred by employing the fixture mount in the process of immediate impression taking and as an immediate provisional abutment.

  15. The success rate of narrow body implants used for supporting immediate provisional restorations: a pilot feasibility study.

    Science.gov (United States)

    Wang, Hom-Lay; Okayasu, Kozue; Fu, Jia-Hui; Hamerink, Howard A; Layher, Mary G; Rudek, Ivan Elimar

    2012-12-01

    Implants were first designed to be used in the reconstruction of edentulous mandibles. However, with the technological advancement, enormous changes were made to improve the implant design and surface characteristics leading to the wide use of implants in the replacement of missing teeth. During the transition from an edentulous span to a fixed prosthesis, narrow body implants (NBIs) have been proposed to enhance patient comfort and function. Therefore, this study was aimed at investigating the survival and success rates of NBIs used for supporting immediately nonfunctional loaded provisional fixed partial denture (PFPD). Either 2.2- or 2.4-mm-diameter dental implants were placed transmucosally into the edentulous ridges of 10 partially edentulous patients. PFPD of self-cured bis-acryl composite material were made using either a vacuform template chairside or a relined prefabricated PFPD. Occlusal adjustments were made to ensure that there was no functional loading on the provisional restorations before they were secured onto the transitional implants. At 1 year, the implant success and survival rates were 38.7% and 93.5%, respectively, with a mean percentage of bone loss of 9.46% (0%-40%) and a mean bone loss of 1.19 mm (range: 0-3.5 mm). With a favorable implant survival rate, the use of NBIs to support provisional restorations seemed to be a feasible treatment option. In addition, there is merit for research on the long-term use of NBIs-supported final prostheses.

  16. Effect of dentin adhesives used as sealers and provisional cementation on bond strength of a resin cement to dentin.

    Science.gov (United States)

    Chieffi, Nicoletta; Sadek, Fernanda; Monticelli, Francesca; Goracci, Cecilia; Grandini, Simone; Davidson, Carel; Tay, Franklin R; Ferrari, Marco

    2006-04-01

    To evaluate the effects of dentin adhesives employed as resin sealers and provisional cementation on the bond strengths of a resin cement to dentin. A two-step etch-and-rinse adhesive (Excite DSC--Group 1) and two-step self-etch adhesive (AdheSE--Group 2) were applied to exposed dentin surfaces prepared from human molars (N=4). Water was used instead of a resin sealer in control Groups 3 and 4. A eugenol-free provisional cement (except for Group 4) was applied to the treated surfaces. After storing in distilled water for 1 week, the provisional cement was removed and cylindrical composite blocks were luted with a resin cement (Variolink II). 0.9 x 0.9 mm sticks were produced from these luted specimens for microtensile bond testing and SEM examination. One-way ANOVA revealed that neither the resin sealer nor the temporary eugenol-free cement had a negative effect on the final bond strength (P> 0.05). Mixed failures were predominantly identified from SEM.

  17. Immediate implant placement and provisionalization with and without a connective tissue graft: an analysis of facial gingival tissue thickness.

    Science.gov (United States)

    Rungcharassaeng, Kitichai; Kan, Joseph Y K; Yoshino, Shuji; Morimoto, Taichiro; Zimmerman, Grenith

    2012-12-01

    Facial gingival tissue thickness (FGTT) is important for an esthetically pleasing anterior restoration since it determines the soft tissue's ability to conceal the underlying restorative material. The purpose of this study was to investigate the change in FGTT after immediate implant placement and provisionalization with and without a connective tissue graft. Patients with a failing maxillary anterior tooth planned for immediate implant placement and provisionalization with (CT group) or without (NCT group) a subepithelial connective tissue graft were included in this study. After tooth extraction, direct measurement of the FGTT was performed; subsequent measurements were performed at the time of definitive prosthesis placement. Data were analyzed using independent and paired t tests at a significance level of α = .05. There was no statistically significant difference in the mean FGTT at tooth extraction between the CT and NCT groups. At prosthesis delivery, the mean FGTT for the CT group was significantly greater than that of the NCT group. The mean FGTT of both groups at prosthesis delivery was significantly higher than that at tooth extraction. The mean change in FGTT in the CT group was also significantly greater than that in the NCT group. Immediate implant placement and provisionalization in conjunction with a connective tissue graft is more likely to result in sufficient peri-implant tissue thickness to conceal underlying implant restorative materials than when performed without a connective tissue graft.

  18. From Fault-tolerance to Attack Tolerance

    Science.gov (United States)

    2011-04-02

    AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Means to build fault - tolerant ...bottlenecks. We also implemented a distributed storage service that uses Byzantine Quo- rum Systems (rather than state machine replication) and employs...From Fault - tolerance to Attack Tolerance AFOSR Grant F9550-06-1-0019 Final Report 1 December 2005 – 30 November 2010 Fred B. Schneider Computer

  19. Decomposition using Maximum Autocorrelation Factors

    DEFF Research Database (Denmark)

    Larsen, Rasmus

    2002-01-01

    are organised in a two-dimensional grid. Another example is biological shape analysis. Here each observation (e.g. human bone, cerebral ventricle) is represented by a number of landmarks the coordinates of which are the variables. Here we do not have an ordering of the observations (individuals). However......, normally we have an ordering of landmarks (variables) along the contour of the objects. For the case with observation ordering the maximum autocorrelation factor (MAF) transform was proposed for multivariate imagery in\\verb+~+\\$\\backslash\\$cite{switzer85}. This corresponds to a R-mode analyse of the data...

  20. Generic maximum likely scale selection

    DEFF Research Database (Denmark)

    Pedersen, Kim Steenstrup; Loog, Marco; Markussen, Bo

    2007-01-01

    in this work is on applying this selection principle under a Brownian image model. This image model provides a simple scale invariant prior for natural images and we provide illustrative examples of the behavior of our scale estimation on such images. In these illustrative examples, estimation is based......The fundamental problem of local scale selection is addressed by means of a novel principle, which is based on maximum likelihood estimation. The principle is generally applicable to a broad variety of image models and descriptors, and provides a generic scale estimation methodology. The focus...

  1. Carbon Equivalent and Maximum Hardness

    OpenAIRE

    Haruyoshi, Suzuki; Head Office, Nippon Steel Corporation

    1984-01-01

    The accuracy of formulae for estimating the maximum hardness values of the HAZ from chemical composition and cooling time for welds in high strength steel is discussed and a new formula. NSC-S, is proposed which uses only C%, Pcm% and cooling time for the purpose of satisfactory accuracy. IIW CE and Ito-Bessyo Pcm carbon equivalent alone are not satisfactory in establishing Hmax values. The former is good only for slow cooling, t8/5 longer than 10 seconds, while the latter is good only for fa...

  2. The Fault-Tolerant Facility Location Problem with Submodular Penalties

    OpenAIRE

    Kamiyama, Naoyuki

    2013-01-01

    In this paper, we consider the fault-tolerant facility location problem with submodular penal- ties that is a common generalization of the fault-tolerant facility location problem and the facility location problem with submodular penalties. For this problem, we present a combinatorial 3 • HR -approximation algorithm, where R is the maximum connectivity requirement and HR is the R-th harmonic number. Our algorithm is a common generalization of the algorithm for the the fault-tolerant facility ...

  3. Last Glacial Maximum in Poland

    Science.gov (United States)

    Marks, Leszek

    2002-01-01

    The Last Glacial Maximum (LGM) in Poland is represented by the Leszno Phase and occurred after 21 ka radiocarbon years. In turn the deglacial Poznań Phase is estimated at 18.4 ka, the Pomeranian Phase at 15.2 ka, the Gardno Phase at about 14.0-13.8 ka, the Słupsk Bank Phase at 13.5-13.2 ka and the Southern Middle Bank Phase at 12.7-12.5 ka BP. The ice sheet limit at LGM was not synchronous everywhere in Poland but occurred as several major and minor ice lobes that reflected a stream-like structure of the ice body that radiated southwards from the Baltic Basin. Meltwater runoff during the LGM created a complex system of sandur trains and ice-marginal spillways, with numerous intervening proglacial lakes.

  4. Objects of maximum electromagnetic chirality

    CERN Document Server

    Fernandez-Corbaton, Ivan

    2015-01-01

    We introduce a definition of the electromagnetic chirality of an object and show that it has an upper bound. The upper bound is attained if and only if the object is transparent for fields of one handedness (helicity). Additionally, electromagnetic duality symmetry, i.e. helicity preservation upon scattering, turns out to be a necessary condition for reciprocal scatterers to attain the upper bound. We use these results to provide requirements for the design of such extremal scatterers. The requirements can be formulated as constraints on the polarizability tensors for dipolar scatterers or as material constitutive relations. We also outline two applications for objects of maximum electromagnetic chirality: A twofold resonantly enhanced and background free circular dichroism measurement setup, and angle independent helicity filtering glasses.

  5. Maximum mutual information regularized classification

    KAUST Repository

    Wang, Jim Jing-Yan

    2014-09-07

    In this paper, a novel pattern classification approach is proposed by regularizing the classifier learning to maximize mutual information between the classification response and the true class label. We argue that, with the learned classifier, the uncertainty of the true class label of a data sample should be reduced by knowing its classification response as much as possible. The reduced uncertainty is measured by the mutual information between the classification response and the true class label. To this end, when learning a linear classifier, we propose to maximize the mutual information between classification responses and true class labels of training samples, besides minimizing the classification error and reducing the classifier complexity. An objective function is constructed by modeling mutual information with entropy estimation, and it is optimized by a gradient descend method in an iterative algorithm. Experiments on two real world pattern classification problems show the significant improvements achieved by maximum mutual information regularization.

  6. System for Memorizing Maximum Values

    Science.gov (United States)

    Bozeman, Richard J., Jr. (Inventor)

    1996-01-01

    The invention discloses a system capable of memorizing maximum sensed values. The system includes conditioning circuitry which receives the analog output signal from a sensor transducer. The conditioning circuitry rectifies and filters the analog signal and provides an input signal to a digital driver, which may be either liner or logarithmic. The driver converts the analog signal to discrete digital values, which in turn triggers an output signal on one of a plurality of driver output lines n. The particular output lines selected is dependent on the converted digital value. A microfuse memory device connects across the driver output lines, with n segments. Each segment is associated with one driver output line, and includes a microfuse that is blown when a signal appears on the associated driver output line.

  7. Provisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development

    Science.gov (United States)

    Wolk, Omri; Agbaria, Riad; Dahan, Arik

    2014-01-01

    The main objective of this work was to investigate in-silico predictions of physicochemical properties, in order to guide oral drug development by provisional biopharmaceutics classification system (BCS). Four in-silico methods were used to estimate LogP: group contribution (CLogP) using two different software programs, atom contribution (ALogP), and element contribution (KLogP). The correlations (r2) of CLogP, ALogP and KLogP versus measured LogP data were 0.97, 0.82, and 0.71, respectively. The classification of drugs with reported intestinal permeability in humans was correct for 64.3%–72.4% of the 29 drugs on the dataset, and for 81.82%–90.91% of the 22 drugs that are passively absorbed using the different in-silico algorithms. Similar permeability classification was obtained with the various in-silico methods. The in-silico calculations, along with experimental melting points, were then incorporated into a thermodynamic equation for solubility estimations that largely matched the reference solubility values. It was revealed that the effect of melting point on the solubility is minor compared to the partition coefficient, and an average melting point (162.7°C) could replace the experimental values, with similar results. The in-silico methods classified 20.76% (±3.07%) as Class 1, 41.51% (±3.32%) as Class 2, 30.49% (±4.47%) as Class 3, and 6.27% (±4.39%) as Class 4. In conclusion, in-silico methods can be used for BCS classification of drugs in early development, from merely their molecular formula and without foreknowledge of their chemical structure, which will allow for the improved selection, engineering, and developability of candidates. These in-silico methods could enhance success rates, reduce costs, and accelerate oral drug products development. PMID:25284986

  8. Nest-representable tolerances

    OpenAIRE

    Lipparini, Paolo

    2017-01-01

    We introduce the notion of a nest-representable tolerance and show that some results from our former paper "From congruence identities to tolerance identities" [CT] can be extended to this more general setting.

  9. Software fault tolerance

    OpenAIRE

    Kazinov, Tofik Hasanaga; Mostafa, Jalilian Shahrukh

    2009-01-01

    Because of our present inability to produce errorfree software, software fault tolerance is and will contiune to be an important consideration in software system. The root cause of software design errors in the complexity of the systems. This paper surveys various software fault tolerance techniquest and methodologies. They are two gpoups: Single version and Multi version software fault tolerance techniques. It is expected that software fault tolerance research will benefit from this research...

  10. The EBC TWO Study (European Bifurcation Coronary TWO): A Randomized Comparison of Provisional T-Stenting Versus a Systematic 2 Stent Culotte Strategy in Large Caliber True Bifurcations.

    Science.gov (United States)

    Hildick-Smith, David; Behan, Miles W; Lassen, Jens F; Chieffo, Alaide; Lefèvre, Thierry; Stankovic, Goran; Burzotta, Francesco; Pan, Manuel; Ferenc, Miroslaw; Bennett, Lorraine; Hovasse, Thomas; Spence, Mark J; Oldroyd, Keith; Brunel, Philippe; Carrie, Didier; Baumbach, Andreas; Maeng, Michael; Skipper, Nicola; Louvard, Yves

    2016-09-01

    For the treatment of coronary bifurcation lesions, a provisional strategy is superior to systematic 2-stent techniques for the most bifurcation lesions. However, complex anatomies with large side branches (SBs) with significant ostial disease length are considered by expert consensus to warrant a 2-stent technique upfront. This consensus view has not been scientifically assessed. Symptomatic patients with large caliber true bifurcation lesions (SB diameter ≥2.5 mm) and significant ostial disease length (≥5 mm) were randomized to either a provisional T-stent strategy or a dual stent culotte technique. Two hundred patients aged 64±10 years, 82% male, were randomized in 20 European centers. The clinical presentations were stable coronary disease (69%) and acute coronary syndromes (31%). SB stent diameter (2.67±0.27 mm) and length (20.30±5.89 mm) confirmed the extent of SB disease. Procedural success (provisional 97%, culotte 94%) and kissing balloon inflation (provisional 95%, culotte 98%) were high. Sixteen percent of patients in the provisional group underwent T-stenting. The primary end point (a composite of death, myocardial infarction, and target vessel revascularization at 12 months) occurred in 7.7% of the provisional T-stent group versus 10.3% of the culotte group (hazard ratio, 1.02; 95% confidence interval, 0.78-1.34; P=0.53). Procedure time, x-ray dose, and cost all favored the simpler procedure. When treating complex coronary bifurcation lesions with large stenosed SBs, there is no difference between a provisional T-stent strategy and a systematic 2-stent culotte strategy in a composite end point of death, myocardial infarction, and target vessel revascularization at 12 months. URL: http://www.clinicaltrials.gov. Unique identifier: NCT 01560455. © 2016 American Heart Association, Inc.

  11. Developing a provisional, international minimal dataset for Juvenile Dermatomyositis: for use in clinical practice to inform research.

    Science.gov (United States)

    McCann, Liza J; Arnold, Katie; Pilkington, Clarissa A; Huber, Adam M; Ravelli, Angelo; Beard, Laura; Beresford, Michael W; Wedderburn, Lucy R

    2014-01-01

    Juvenile dermatomyositis (JDM) is a rare but severe autoimmune inflammatory myositis of childhood. International collaboration is essential in order to undertake clinical trials, understand the disease and improve long-term outcome. The aim of this study was to propose from existing collaborative initiatives a preliminary minimal dataset for JDM. This will form the basis of the future development of an international consensus-approved minimum core dataset to be used both in clinical care and inform research, allowing integration of data between centres. A working group of internationally-representative JDM experts was formed to develop a provisional minimal dataset. Clinical and laboratory variables contained within current national and international collaborative databases of patients with idiopathic inflammatory myopathies were scrutinised. Judgements were informed by published literature and a more detailed analysis of the Juvenile Dermatomyositis Cohort Biomarker Study and Repository, UK and Ireland. A provisional minimal JDM dataset has been produced, with an associated glossary of definitions. The provisional minimal dataset will request information at time of patient diagnosis and during on-going prospective follow up. At time of patient diagnosis, information will be requested on patient demographics, diagnostic criteria and treatments given prior to diagnosis. During on-going prospective follow-up, variables will include the presence of active muscle or skin disease, major organ involvement or constitutional symptoms, investigations, treatment, physician global assessments and patient reported outcome measures. An internationally agreed minimal dataset has the potential to significantly enhance collaboration, allow effective communication between groups, provide a minimal standard of care and enable analysis of the largest possible number of JDM patients to provide a greater understanding of this disease. This preliminary dataset can now be developed into

  12. A comparative evaluation of the marginal accuracy of crowns fabricated from four commercially available provisional materials: An in vitrostudy

    Directory of Open Access Journals (Sweden)

    Bhavya Mohandas Amin

    2015-01-01

    Full Text Available Purpose: The purpose of this in vitro study was to evaluate and compare the primary marginal accuracy of four commercially available provisional materials (Protemp 4, Luxatemp Star, Visalys Temp and DPI tooth moulding powder and liquid at 2 time intervals (10 and 30 min. Materials and Methods: A customized stainless steel master model containing two interchangeable dies was used for fabrication of provisional crowns. Forty crowns (n = 10 were fabricated, and each crown was evaluated under a stereomicroscope. Vertical marginal discrepancies were noted and compared at 10 min since the start of mixing and then at 30 min. Observations and Results: Protemp 4 showed the least vertical marginal discrepancy (71.59 μ, followed by Luxatemp Star (91.93 μ at 10 min. DPI showed a marginal discrepancy of 95.94 μ while Visalys Temp crowns had vertical marginal discrepancy of 106.81 μ. There was a significant difference in the marginal discrepancy values of Protemp 4 and Visalys Temp. At 30 min, there was a significant difference between the marginal discrepancy of Protemp 4 crowns (83.11 μ and Visalys Temp crowns (128.97 μ and between Protemp 4 and DPI (118.88 μ. No significant differences were observed between Protemp 4 and Luxatemp Star. Conclusion: The vertical marginal discrepancy of temporary crowns fabricated from the four commercially available provisional materials ranged from 71 to 106 μ immediately after fabrication (at 10 min from the start of mix to 83-128 μ (30 min from the start of mix. The time elapsed after mixing had a significant influence on the marginal accuracy of the crowns.

  13. A comparative evaluation of the marginal accuracy of crowns fabricated from four commercially available provisional materials: An in vitro study

    Science.gov (United States)

    Amin, Bhavya Mohandas; Aras, Meena Ajay; Chitre, Vidya

    2015-01-01

    Purpose: The purpose of this in vitro study was to evaluate and compare the primary marginal accuracy of four commercially available provisional materials (Protemp 4, Luxatemp Star, Visalys Temp and DPI tooth moulding powder and liquid) at 2 time intervals (10 and 30 min). Materials and Methods: A customized stainless steel master model containing two interchangeable dies was used for fabrication of provisional crowns. Forty crowns (n = 10) were fabricated, and each crown was evaluated under a stereomicroscope. Vertical marginal discrepancies were noted and compared at 10 min since the start of mixing and then at 30 min. Observations and Results: Protemp 4 showed the least vertical marginal discrepancy (71.59 μ), followed by Luxatemp Star (91.93 μ) at 10 min. DPI showed a marginal discrepancy of 95.94 μ while Visalys Temp crowns had vertical marginal discrepancy of 106.81 μ. There was a significant difference in the marginal discrepancy values of Protemp 4 and Visalys Temp. At 30 min, there was a significant difference between the marginal discrepancy of Protemp 4 crowns (83.11 μ) and Visalys Temp crowns (128.97 μ) and between Protemp 4 and DPI (118.88 μ). No significant differences were observed between Protemp 4 and Luxatemp Star. Conclusion: The vertical marginal discrepancy of temporary crowns fabricated from the four commercially available provisional materials ranged from 71 to 106 μ immediately after fabrication (at 10 min from the start of mix) to 83–128 μ (30 min from the start of mix). The time elapsed after mixing had a significant influence on the marginal accuracy of the crowns. PMID:26097348

  14. Mechanical tolerance stackup and analysis

    CERN Document Server

    Fischer, Bryan R

    2004-01-01

    BackgroundDimensioning and TolerancingTolerance Format and Decimal PlacesConverting Plus/Minus Dimensions and Tolerances into Equal Bilaterally Toleranced DimensionsVariation and Sources of VariationTolerance AnalysisWorst-case Tolerance StackupsStatistical Tolerance StackupsGeometric Dimensioning and Tolerancing (GD&T)Converting Plus/Minus Tolerancing to Positional Tolerancing and Projected Tolerance ZonesDiametral and Radial Tolerance StackupsSpecifying Material Condition Modifiers and Their Effect on Tolerance Stackups The Tolerance Stackup SketchThe Tolerance Stackup Report FormTolerance S

  15. Vestige: Maximum likelihood phylogenetic footprinting

    Directory of Open Access Journals (Sweden)

    Maxwell Peter

    2005-05-01

    Full Text Available Abstract Background Phylogenetic footprinting is the identification of functional regions of DNA by their evolutionary conservation. This is achieved by comparing orthologous regions from multiple species and identifying the DNA regions that have diverged less than neutral DNA. Vestige is a phylogenetic footprinting package built on the PyEvolve toolkit that uses probabilistic molecular evolutionary modelling to represent aspects of sequence evolution, including the conventional divergence measure employed by other footprinting approaches. In addition to measuring the divergence, Vestige allows the expansion of the definition of a phylogenetic footprint to include variation in the distribution of any molecular evolutionary processes. This is achieved by displaying the distribution of model parameters that represent partitions of molecular evolutionary substitutions. Examination of the spatial incidence of these effects across regions of the genome can identify DNA segments that differ in the nature of the evolutionary process. Results Vestige was applied to a reference dataset of the SCL locus from four species and provided clear identification of the known conserved regions in this dataset. To demonstrate the flexibility to use diverse models of molecular evolution and dissect the nature of the evolutionary process Vestige was used to footprint the Ka/Ks ratio in primate BRCA1 with a codon model of evolution. Two regions of putative adaptive evolution were identified illustrating the ability of Vestige to represent the spatial distribution of distinct molecular evolutionary processes. Conclusion Vestige provides a flexible, open platform for phylogenetic footprinting. Underpinned by the PyEvolve toolkit, Vestige provides a framework for visualising the signatures of evolutionary processes across the genome of numerous organisms simultaneously. By exploiting the maximum-likelihood statistical framework, the complex interplay between mutational

  16. Vestige: maximum likelihood phylogenetic footprinting.

    Science.gov (United States)

    Wakefield, Matthew J; Maxwell, Peter; Huttley, Gavin A

    2005-05-29

    Phylogenetic footprinting is the identification of functional regions of DNA by their evolutionary conservation. This is achieved by comparing orthologous regions from multiple species and identifying the DNA regions that have diverged less than neutral DNA. Vestige is a phylogenetic footprinting package built on the PyEvolve toolkit that uses probabilistic molecular evolutionary modelling to represent aspects of sequence evolution, including the conventional divergence measure employed by other footprinting approaches. In addition to measuring the divergence, Vestige allows the expansion of the definition of a phylogenetic footprint to include variation in the distribution of any molecular evolutionary processes. This is achieved by displaying the distribution of model parameters that represent partitions of molecular evolutionary substitutions. Examination of the spatial incidence of these effects across regions of the genome can identify DNA segments that differ in the nature of the evolutionary process. Vestige was applied to a reference dataset of the SCL locus from four species and provided clear identification of the known conserved regions in this dataset. To demonstrate the flexibility to use diverse models of molecular evolution and dissect the nature of the evolutionary process Vestige was used to footprint the Ka/Ks ratio in primate BRCA1 with a codon model of evolution. Two regions of putative adaptive evolution were identified illustrating the ability of Vestige to represent the spatial distribution of distinct molecular evolutionary processes. Vestige provides a flexible, open platform for phylogenetic footprinting. Underpinned by the PyEvolve toolkit, Vestige provides a framework for visualising the signatures of evolutionary processes across the genome of numerous organisms simultaneously. By exploiting the maximum-likelihood statistical framework, the complex interplay between mutational processes, DNA repair and selection can be evaluated both

  17. The dual-zone therapeutic concept of managing immediate implant placement and provisional restoration in anterior extraction sockets.

    Science.gov (United States)

    Chu, Stephen J; Salama, Maurice A; Salama, Henry; Garber, David A; Saito, Hanae; Sarnachiaro, Guido O; Tarnow, Dennis P

    2012-01-01

    Improvements in implant designs have helped advance successful immediate anterior implant placement into fresh extraction sockets. Clinical techniques described in this case enable practitioners to achieve predictable esthetic success using a method that limits the amount of buccal contour change of the extraction site ridge and potentially enhances the thickness of the peri-implant soft tissues coronal to the implant-abutment interface. This approach involves atraumatic tooth removal without flap elevation, and placing a bone graft into the residual gap around an immediate fresh-socket anterior implant with a screw-retained provisional restoration acting as a prosthetic socket seal device.

  18. A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo

    Science.gov (United States)

    Davidson, Eric H.; Rast, Jonathan P.; Oliveri, Paola; Ransick, Andrew; Calestani, Cristina; Yuh, Chiou-Hwa; Minokawa, Takuya; Amore, Gabriele; Hinman, Veronica; Arenas-Mena, Cesar; hide

    2002-01-01

    We present the current form of a provisional DNA sequence-based regulatory gene network that explains in outline how endomesodermal specification in the sea urchin embryo is controlled. The model of the network is in a continuous process of revision and growth as new genes are added and new experimental results become available; see http://www.its.caltech.edu/mirsky/endomeso.htm (End-mes Gene Network Update) for the latest version. The network contains over 40 genes at present, many newly uncovered in the course of this work, and most encoding DNA-binding transcriptional regulatory factors. The architecture of the network was approached initially by construction of a logic model that integrated the extensive experimental evidence now available on endomesoderm specification. The internal linkages between genes in the network have been determined functionally, by measurement of the effects of regulatory perturbations on the expression of all relevant genes in the network. Five kinds of perturbation have been applied: (1) use of morpholino antisense oligonucleotides targeted to many of the key regulatory genes in the network; (2) transformation of other regulatory factors into dominant repressors by construction of Engrailed repressor domain fusions; (3) ectopic expression of given regulatory factors, from genetic expression constructs and from injected mRNAs; (4) blockade of the beta-catenin/Tcf pathway by introduction of mRNA encoding the intracellular domain of cadherin; and (5) blockade of the Notch signaling pathway by introduction of mRNA encoding the extracellular domain of the Notch receptor. The network model predicts the cis-regulatory inputs that link each gene into the network. Therefore, its architecture is testable by cis-regulatory analysis. Strongylocentrotus purpuratus and Lytechinus variegatus genomic BAC recombinants that include a large number of the genes in the network have been sequenced and annotated. Tests of the cis-regulatory predictions of

  19. Comparison of some properties of four provisional restorations resin: Trim, Tempron, Acropars TRII & Duralay (Aria Dent

    Directory of Open Access Journals (Sweden)

    Monzavi A.

    2006-08-01

    Full Text Available Background and Aim: Use of provisional restorations is one of the important phases in the treatment of patients who need fixed prosthesis. Some physical properties are required for these materials. The purpose of this study was the comparison of some physical properties of 4 kinds of resins: Trim, Tempron, Duralay (Aria Dent and Acropars TRII. Materials and Methods: In this experimental study, transverse-strength (TS, setting time (ST, polymerization shrinkage (PS and temperature rise (TR during polymerization were tested. In transverse strength test, 5 samples of each resin were made. TS testing was done with an Instron testing machine. ST testing (5 samples in each group was done with Gilmore needle. In PS test, 11 cylindric samples were prepared from each resin and the shrinkage was examined with digital micrometer (up to 24 hours. In TR test, after mixing the powder and liquid of resins (8 samples in each group, the temperature rise was recorded with 10 seconds interval (up to 15 minutes. Data were analyzed with one-way ANOVA and Tukey HSD tests with p<0.05 as the limit of significance. Results: In TS test, all samples of Trim were bent and no fracture was observed, while Tempron and Duralay showed no significant difference. Both Tempron and Duralay revealed high significant difference with Acropars TRII (P <0.01. In ST test, the difference between groups was significant (P<0.01. The lowest ST was observed in Acropars TRII (7 min, and the highest in Tempron (9.53 min. In PS test, significant difference was observed between Trim and Acropars TRII (P<0.01. PS was completed after 120 min in Tempron and Trim groups. However, PS continued to increase in other groups. In TR test, the difference between groups was significant (P<0.05. Duralay showed the highest TR and the lowest was seen in Trim. Conclusion: In this study, Trim showed better properties than other studied groups. Acropars TRII had the lowest strength. The highest temperature rise

  20. Provisional in-silico biopharmaceutics classification (BCS to guide oral drug product development

    Directory of Open Access Journals (Sweden)

    Wolk O

    2014-09-01

    Full Text Available Omri Wolk, Riad Agbaria, Arik Dahan Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel Abstract: The main objective of this work was to investigate in-silico predictions of physicochemical properties, in order to guide oral drug development by provisional biopharmaceutics classification system (BCS. Four in-silico methods were used to estimate LogP: group contribution (CLogP using two different software programs, atom contribution (ALogP, and element contribution (KLogP. The correlations (r2 of CLogP, ALogP and KLogP versus measured LogP data were 0.97, 0.82, and 0.71, respectively. The classification of drugs with reported intestinal permeability in humans was correct for 64.3%–72.4% of the 29 drugs on the dataset, and for 81.82%–90.91% of the 22 drugs that are passively absorbed using the different in-silico algorithms. Similar permeability classification was obtained with the various in-silico methods. The in-silico calculations, along with experimental melting points, were then incorporated into a thermodynamic equation for solubility estimations that largely matched the reference solubility values. It was revealed that the effect of melting point on the solubility is minor compared to the partition coefficient, and an average melting point (162.7°C could replace the experimental values, with similar results. The in-silico methods classified 20.76% (±3.07% as Class 1, 41.51% (±3.32% as Class 2, 30.49% (±4.47% as Class 3, and 6.27% (±4.39% as Class 4. In conclusion, in-silico methods can be used for BCS classification of drugs in early development, from merely their molecular formula and without foreknowledge of their chemical structure, which will allow for the improved selection, engineering, and developability of candidates. These in-silico methods could enhance success rates, reduce costs, and accelerate oral drug products development

  1. Provisional clinical chemistry parameters in the African Sharptooth catfish (Clarias gariepinus

    Directory of Open Access Journals (Sweden)

    J.G. Myburgh

    2008-05-01

    Full Text Available This is a reprint of Myburgh, J.G. Botha, C.J. Booyse, D.G. & Reyers, F., 2008, 'Provisional clinical chemistry parameters in the African Sharptooth catfish (Clarias gariepinus', Journal of the South African Veterinary Association 79(4, 156-160. http://dx.doi.org/10.4102/jsava.v79i4.265:Pollution affects aquatic systems worldwide and there is an urgent need for efficient monitoring. Fish are generally sensitive to their environment and are thus considered to be valuable bioindicator species. The African Sharptooth catfish (Clarias gariepinus is particularly important in this respect because of its very wide distribution. In order to use C. gariepinus as a bioindicator species its baseline clinical chemistry must be defined. Existing data are scarce, and the objective of this work was therefore to establish clinical chemistry parameters for C. gariepinus. Blood was collected from male and female catfish and a number of clinical chemistry parameters were determined. Plasma protein values, but particularly those of plasma albumin, were found to be very low, approximately half the value for dogs, but similar to the values in Channel catfish (Ictalurus punctatus. Plasma urea values in Sharptooth catfish were found to be much lower than in dogs, but only marginally lower than in Channel catfish. Plasma creatinine in Sharptooth catfish, however, was only a quarter of that of dogs and one third of that found in Channel catfish. These findings may have implications for using urea and / or creatinine as an index of renal glomerular filtration, as is done in mammals. Plasma enzyme activity ranges were much lower in Sharptooth catfish than in dogs, particularly for alkaline phosphatase (ALP and alanine aminotransferase (ALT. By comparison, Channel catfish have an even lower ALT activity range but an ALP range that is very similar to dogs. The implications for using these enzymes as markers for liver disease are not clear from these data, as factors such as

  2. Esthetic Outcome of Implant Supported Crowns With and Without Peri-Implant Conditioning Using Provisional Fixed Prosthesis: A Randomized Controlled Clinical Trial.

    Science.gov (United States)

    Furze, David; Byrne, Ashley; Alam, Sonia; Wittneben, Julia-Gabriela

    2016-12-01

    Achieving an optimal esthetic result using dental implants is challenging. Fixed implant-supported provisional crowns are often used to customize the emergence profile and to individualize the surrounding peri-implant soft tissue. The objective of this study is to evaluate whether the use of a provisional implant-supported crown leads to an esthetic benefit on implants that are placed in the esthetic zone. The null hypothesis is that there is no-difference between the two study groups. Twenty single implants (Bone Level, Straumann AG, Basel, Switzerland) were inserted in consecutive patients. After reopening, a randomization process assigned them to either cohort group 1: a provisional phase with soft tissue conditioning using the "dynamic compression technique" or cohort group 2: without a provisional. Implants were finally restored with an all-ceramic crown. Follow-up examinations were performed at 3 and 12 months including implant success and survival, clinical, and radiographic parameters. After 1 year all implants successfully integrated, mean values of combined modPES and WES were 16.7 for group 1 and 10.5 for Group 2. This was statistically significant. Mean bone loss after 1 year was -0.09 and -0.08 for groups 1 and 2, respectively, without being statistically significant. A provisional phase with soft tissue conditioning does improve the final esthetic result. © 2016 Wiley Periodicals, Inc.

  3. 75 FR 76284 - Pesticide Tolerance Crop Grouping Program II; Revisions to General Tolerance Regulations

    Science.gov (United States)

    2010-12-08

    ... post-harvest uses. The crop grouping concept leads to an estimate of the maximum residue that could... post-harvest use. The commenter asserted that growers need to know what residues they should expect....S. tolerance level with the international MRL will indicate to a grower that pre-harvest treatment...

  4. Toleration out of respect?

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2014-01-01

    be based on a modus vivendi designed to secure peaceful co-existence, but should be based on moral reasons. Forst therefore advances what he calls the ‘respect conception’ of toleration as an in itself morally desirable type of relationship, which is furthermore the only conception of toleration......Under conditions of pluralism different cultures, interests or values can come into conflict, which raises the problem of how to secure peaceful co-existence. The idea of toleration historically emerged as an answer to this problem. Recently Rainer Forst has argued that toleration should not just...... that avoids various so-called ‘paradoxes of toleration’. The paper first examines whether Forst’s respect conception can be applied descriptively to distinguish between actual patterns of behaviour and classify different acts of toleration. Then the focus is shifted to toleration out of respect as a normative...

  5. Effect of Heat Treatment on the Physical Properties of Provisional Crowns during Polymerization: An in Vitro Study

    Directory of Open Access Journals (Sweden)

    May L. Mei

    2015-04-01

    Full Text Available This study concerned the effect of heat treatment during setting on the physical properties of four resin-based provisional restorative materials: Duralay (polymethyl methacrylate, Trim II (polyethyl methacrylate, Luxatemp (bis-acrylic composite, and Protemp 4 (bis-acrylic composite. Specimens were prepared at 23, 37, or 60 °C for evaluation of flexural strength, surface roughness, color change and marginal discrepancy. Flexural strength was determined by a three-point bending test. Surface profile was studied using atomic force microscopy. Color change was evaluated by comparing the color of the materials before and after placement in coffee. A travelling microscope helped prepare standardized crowns for assessment of marginal discrepancy. Flexural strength of all tested materials cured at 23 °C or 37 °C did not significantly change. The surface roughness and marginal discrepancy of the materials increased at 60 °C curing temperature. Marginal discrepancies, color stability, and other physical properties of materials cured at 23 °C or 37 °C did not significantly change. Flexural strength of certain provisional materials cured at 60 °C increased, but there was also an increase in surface roughness and marginal discrepancy.

  6. The effect of dentin desensitizers on thermal changes in the pulp chamber during fabrication of provisional restorations.

    Science.gov (United States)

    Usumez, A; Ozturk, A N; Aykent, F

    2004-06-01

    The purpose of this study was to evaluate the effect of two dentin desensitizers on the pulp chamber temperature increase during fabrication of provisional restorations by a direct method. Sixty intact extracted mandibular third molars were prepared for a metal-ceramic complete crown. Then the teeth were randomly divided into three groups of 20 each. Group 1, no dentin desensitizer was used as the control group; group 2, a resin-based dentin desensitizer was selected; and group 3, the prepared teeth surfaces were coated with polyurethane cyanoacrylate adhesive. Each of the three groups was further divided into two polymerizing systems (autopolymerizing and a photopolymerizing) of 10 each. After insertion of the resin-filled matrix, the temperature change in the pulpal chamber was recorded with thermocouple connected to a data logger. anova indicated no significant differences for all combinations of desensitizing agents and curing methods (P > 0.05). When light cured composite or chemical curing acrylics were used to make temporary crowns, the presence of desensitizing agent did not reduce the temperature transmitted from the provisional material; the residual temperature rise transmitted was of such a magnitude as to cause concern regarding possible thermal injury to pulp.

  7. A "Jail Escape Technique" (JET) for distal side branch wiring during provisional stenting: Feasibility and first-in-man study.

    Science.gov (United States)

    Xiao, Han; Chen, Shengda; Wang, Guixue; Du, Ruolin; Song, Yaoming; Jin, Jun; Huang, Lan; Jabbour, Richard; Azzalini, Lorenzo; Zhao, Xiaohui

    2017-12-01

    To evaluate the feasibility of a novel technique for achieving distal SB access and improve strut apposition during provisional stenting. While distal rewiring and stent expansion toward the side branch (SB) are associated with better results during provisional stenting of coronary artery bifurcation lesions, these techniques are technically challenging and often leave unopposed struts near the carina. The "Jail Escape Technique" (JET) is performed by passing the proximal tip of the SB wire between the main vessel (MV) stent struts and balloon before implantation, allowing the MV stent to push the SB wire against the distal part of the carina. The MV stent can then be deployed without jailing the SB wire. Distal SB access and strut distribution at the carina were tested in phantom and swine models. Stent distortion, dislodgement forces, and material damage were evaluated with tensile testing. Human feasibility was then tested on 32 patients. Preclinical testing demonstrated that the SB wire was located at the most distal part of the carina and no strut malapposition at the carina was present after balloon inflation. Stent distortion, dislodgement forces, or material damage were not affected. JET was successfully performed in 30 of 32 patients. No major adverse cardiovascular events occurred in any patient at 6-month follow-up. The "JET" enables distal SB access and eliminates strut malapposition at the carina. Further studies with larger numbers of patients are needed to further investigate this technique. © 2017, Wiley Periodicals, Inc.

  8. Immediate occlusal loading in edentulous jaws, CT-guided surgery and fixed provisional prosthesis: a maxillary arch clinical report.

    Science.gov (United States)

    Drago, Carl; del Castillo, Robert; Peterson, Thomas

    2011-04-01

    Immediate occlusal loading (IOL) in edentulous jaws has been reported in numerous publications with implant cumulative survival rates consistent with conventional, unloaded healing protocols. Computed Tomography (CT)-guided surgery has more recently been developed and accepted as an additional treatment modality for maxillary and mandibular implant placement, with or without IOL. Reports as to the accuracy of planned versus actual implant placement in CT-guided surgeries have indicated that CT-guided surgery is not 100% accurate; standard deviations have been reported with values between 1 and 2 mm in terms of actual versus planned placement. The purpose of this article is to review the clinical parameters associated with IOL, and CT-guided surgery in edentulous jaws; and to present a clinical case illustrating the clinical and laboratory phases of treatment. The illustrated treatment was accomplished with an IOL protocol and includes fabrication and placement of a laboratory-processed provisional maxillary prosthesis. This particular protocol had slightly increased costs relative to conventional implant placement; however, the clinicians and patient benefited from improved accuracy of the provisional prostheses and decreased chairtime for the clinical procedures. The benefits and limitations of this treatment protocol are also discussed. © 2010 by The American College of Prosthodontists.

  9. Young novice drivers and the risky behaviours of parents and friends during the provisional (intermediate) licence phase: a brief report.

    Science.gov (United States)

    Scott-Parker, Bridie; Watson, Barry; King, Mark J; Hyde, Melissa K

    2014-08-01

    While there is research indicating that many factors influence the young novice driver's increased risk of road crash injury during the earliest stages of their independent driving, there is a need to further understand the relationship between the perceived risky driving behaviour of parents and friends and the risky behaviour of drivers with a Provisional (intermediate) licence. As part of a larger research project, 378 drivers aged 17-25 years (M=18.22, SD=1.59, 113 males) with a Provisional licence completed an online survey exploring the perceived riskiness of their parents' and friends' driving, and the extent to which they pattern (i.e. base) their driving behaviour on the driving of their parents and friends. Young drivers who reported patterning their driving on their friends, and who reported they perceived their friends to be risky drivers, reported more risky driving. The risky driving behaviour of young male drivers was associated with the perceived riskiness of their fathers' driving, whilst for female drivers the perceived riskiness of their mothers' driving approached significance. The development and application of countermeasures targeting the risky behaviour of same-sex parents appears warranted by the robust research findings. In addition, countermeasures need to encourage young people in general to be non-risky drivers; targeting the negative influence of risky peer groups specifically. Social norms interventions may minimise the influence of potentially-overestimated riskiness. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. DK mini-culotte stenting in the treatment of true coronary bifurcation lesions: a propensity score matching comparison with T-provisional stenting.

    Science.gov (United States)

    Fan, Lin; Chen, Lianglong; Luo, Yukun; Zhang, Linlin; Zhong, Wenliang; Lin, Chaogui; Chen, Zhaoyang; Peng, Yafei; Zhen, Xingchun; Dong, Xianfeng

    2016-03-01

    The conventional culotte technique remains not to be widely used for the treatment of coronary bifurcation lesions due to its inherent drawbacks. Here, we developed a double kissing mini-culotte stenting (DK mini-culotte) and assessed its efficacy and safety by a propensity score matching comparison (PSM) with T-provisional stenting. From June 2010 to June 2012, a total of 223 consecutive patients with true coronary bifurcation lesions (TCBLs) were treated with DK mini-culotte (91 patients with 92 lesions) or T-provisional stenting (132 patients with 135 lesions). We performed a PSM to correct the confounders from clinical and lesion's characteristics. The primary endpoint was cumulative major adverse cardiac event (MACE) at 1 year including cardiac death, myocardial infarction, and target vessel revascularization or target lesion revascularization (TVR/TLR). The secondary endpoint was the rate of side branch (SB) restenosis at 12 months. After a PSM, there were 66 patients in each group. Additional SB stenting in the T-provisional group was performed in 10 (15.2 %) lesions. The incidence of 1-year cumulative MACE was 4.55 % for the DK mini-culotte versus 13.6 % for T-provisional stenting (P = 0.127), the rate of TVR/TLR was 1.52 % for DK mini-culotte versus 12.12 % for T-provisional stenting (P = 0.033). The SB binary restenosis rate was 5.6 % in the DK mini-culotte group and 22.4 % in the T-provisional group (P = 0.014). In summary, despite that there is no difference in MACE between groups, DK mini-culotte significantly reduce TVR/TLR and SB restenosis in the treatment of true coronary bifurcation lesions.

  11. Recognition and Toleration

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2010-01-01

    Recognition and toleration are ways of relating to the diversity characteristic of multicultural societies. The article concerns the possible meanings of toleration and recognition, and the conflict that is often claimed to exist between these two approaches to diversity. Different forms or inter......Recognition and toleration are ways of relating to the diversity characteristic of multicultural societies. The article concerns the possible meanings of toleration and recognition, and the conflict that is often claimed to exist between these two approaches to diversity. Different forms...

  12. Sulfur tolerant anode materials

    Energy Technology Data Exchange (ETDEWEB)

    1987-02-01

    The goal of this program is the development of a molten carbonate fuel cell (MCFC) anode which is more tolerant of sulfur contaminants in the fuel than the current state-of-the-art nickel-based anode structures. This program addresses two different but related aspects of the sulfur contamination problem. The primary aspect is concerned with the development of a sulfur tolerant electrocatalyst for the fuel oxidation reaction. A secondary issue is the development of a sulfur tolerant water-gas-shift reaction catalyst and an investigation of potential steam reforming catalysts which also have some sulfur tolerant capabilities. These two aspects are being addressed as two separate tasks.

  13. Toleration, Groups, and Multiculturalism

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2014-01-01

    to the political and social relationship between the subject and the objects of toleration. Finally, toleration is often argued to be a normative requirement on the basis of the way it affects the object or receiver of toleration, e.g. on the basis of the good of or right to freedom from non-interference which....... The chapter relates the different possible meanings of groups toleration to widespread criticisms of multiculturalism for being excessively 'groupist' (e.g. to essentialise or reify groups), to promote group rights over individual rights, or to deny or ignore the internal heterogeneity of groups...

  14. Maximum Power from a Solar Panel

    Directory of Open Access Journals (Sweden)

    Michael Miller

    2010-01-01

    Full Text Available Solar energy has become a promising alternative to conventional fossil fuel sources. Solar panels are used to collect solar radiation and convert it into electricity. One of the techniques used to maximize the effectiveness of this energy alternative is to maximize the power output of the solar collector. In this project the maximum power is calculated by determining the voltage and the current of maximum power. These quantities are determined by finding the maximum value for the equation for power using differentiation. After the maximum values are found for each time of day, each individual quantity, voltage of maximum power, current of maximum power, and maximum power is plotted as a function of the time of day.

  15. Remember Tolerance Differently

    DEFF Research Database (Denmark)

    Tønder, Lars

    2012-01-01

    This essay questions the linear conception of history which often accompanies the way contemporary democratic theory tends to disavow tolerance's discontinuities and remainders. In the spirit of Foucault's genealogy of descent, the idea is to develop a new sense of tolerance's history, not by inv...

  16. Toleration out of respect?

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2013-01-01

    Under conditions of pluralism different cultures, interests or values can come into conflict, which raises the problem of how to secure peaceful co-existence. The idea of toleration historically emerged as an answer to this problem. Recently Rainer Forst has argued that toleration should not just...

  17. Tolerances in micro manufacturing

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Zhang, Yang; Islam, Aminul

    2017-01-01

    This paper describes a method for analysis of tolerances in micro manufacturing. It proposes a mapping oftolerances to dimensions and compares this with current available international standards. The analysisdocuments that tolerances are not scaled down as the absolute dimension. In practice...

  18. Tolerances in micro manufacturing

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Zhang, Yang; Islam, Aminul

    This paper describes a method for analysis of tolerances in micro manufacturing. It proposes a mapping oftolerances to dimensions and compares this with current available international standards. The analysisdocuments that tolerances are not scaled down as the absolute dimension. In practice...

  19. Fault Tolerant Feedback Control

    DEFF Research Database (Denmark)

    Stoustrup, Jakob; Niemann, H.

    2001-01-01

    An architecture for fault tolerant feedback controllers based on the Youla parameterization is suggested. It is shown that the Youla parameterization will give a residual vector directly in connection with the fault diagnosis part of the fault tolerant feedback controller. It turns out that there...

  20. Recognition and Toleration

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2010-01-01

    Recognition and toleration are ways of relating to the diversity characteristic of multicultural societies. The article concerns the possible meanings of toleration and recognition, and the conflict that is often claimed to exist between these two approaches to diversity. Different forms or inter...

  1. Defect Tolerant Semiconductors for Solar Energy Conversion.

    Science.gov (United States)

    Zakutayev, Andriy; Caskey, Christopher M; Fioretti, Angela N; Ginley, David S; Vidal, Julien; Stevanovic, Vladan; Tea, Eric; Lany, Stephan

    2014-04-03

    Defect tolerance is the tendency of a semiconductor to keep its properties despite the presence of crystallographic defects. Scientific understanding of the origin of defect tolerance is currently missing. Here we show that semiconductors with antibonding states at the top of the valence band are likely to be tolerant to defects. Theoretical calculations demonstrate that Cu3N with antibonding valence band maximum has shallow intrinsic defects and no surface states, in contrast to GaN with bonding valence band maximum. Experimental measurements indicate shallow native donors and acceptors in Cu3N thin films, leading to 10(16)-10(17) cm(-3) doping with either electrons or holes depending on the growth conditions. The experimentally measured bipolar doping and the solar-matched optical absorption onset (1.4 eV) make Cu3N a promising candidate absorber for photovoltaic and photoelectrochemical solar cells, despite the calculated indirect fundamental band gap (1.0 eV). These conclusions can be extended to other materials with antibonding character of the valence band, defining a class of defect-tolerant semiconductors for solar energy conversion applications.

  2. Prospective evaluation of a new protocol for the provisional use of perfusion imaging with exercise stress testing

    Energy Technology Data Exchange (ETDEWEB)

    Duvall, W.L. [Hartford Hospital, Division of Cardiology (Henry Low Heart Center), Hartford, CT (United States); Mount Sinai Medical Center, Division of Cardiology (Mount Sinai Heart), New York, NY (United States); Savino, John A.; Levine, Elliot J.; Croft, Lori B.; Henzlova, Milena J. [Mount Sinai Medical Center, Division of Cardiology (Mount Sinai Heart), New York, NY (United States); Hermann, Luke K. [Mount Sinai Medical Center, Department of Emergency Medicine, New York, NY (United States)

    2014-11-04

    Previous literature suggests that myocardial perfusion imaging (MPI) adds little to the prognosis of patients who exercise >10 metabolic equivalents (METs) during stress testing. With this in mind, we prospectively tested a provisional injection protocol in emergency department (ED) patients presenting for the evaluation of chest pain in which a patient would not receive an injection of radioisotope if adequate exercise was achieved without symptoms and a negative ECG response. All patients who presented to the ED over a 5-year period who were referred for stress testing as part of their ED evaluation were included. Patients considered for a provisional protocol were: exercise stress, age <65 years, no known coronary artery disease, and an interpretable rest ECG. Criteria for not injecting included a maximal predicted heart rate ≥85 %, ≥10 METs of exercise, no anginal symptoms during stress, and no ECG changes. Groups were compared based on stress test results, all-cause and cardiac mortality, follow-up cardiac testing, subsequent revascularization, and cost. A total of 965 patients were eligible with 192 undergoing exercise-only and 773 having perfusion imaging. After 41.6 ± 19.6 months of follow-up, all-cause mortality was similar in the exercise-only versus the exercise plus imaging group (2.6 % vs. 2.1 %, p = 0.59). There were no cardiac deaths in the exercise-only group. At 1 year there was no difference in the number of repeat functional stress tests (1.6 % vs. 2.1 %, p = 0.43), fewer angiograms (0 % vs. 4.0 %, p = 0.002), and a significantly lower cost (65 ± 332 vs 506 ± 1,991, p = 0.002; values are in US dollars) in the exercise-only group. The radiation exposure in the exercise plus imaging group was 8.4 ± 2.1 mSv. A provisional injection protocol has a very low mortality, few follow-up diagnostic tests, and lower cost compared to standard imaging protocols. If adopted it would decrease radiation exposure, save time and decrease health-care costs

  3. Biotechnological approach in exploring vegetative desiccation tolerance: from aseptic culture to molecular breeding.

    Science.gov (United States)

    Toldi, O; Dancs, G; Dobrányi, Sz; Gyuricza, Cs; Gémesi, Zs; Scott, P

    2010-01-01

    What is remarkable about resurrection plants is the ability of vegetative tissues (root, shoot, stem, leaves) to tolerate dehydration of the tissues and then return as functional units on rehydration. This phenomenon made resurrection plants exciting targets for molecular analysis of the poikilohydric ability and drought tolerance. The protective mechanisms of vegetative desiccation tolerance appear to involve three major components, sugars, proteins and antioxidants. According to the recent scientific consensus all three are postulated to be involved in maintaining cellular integrity during the drying phases. The aim of this review is to establish a provisional hierarchy among these stress avoiding mechanisms that are associated with desiccation tolerance. The main reason for ranking these signal metabolites and protective agents is their potential importance in practical applications. Although vegetative desiccation tolerance is a complex trait both genetically and physiologically, there are already examples where outcomes of targeted studies in resurrection plants are going to be directly utilized to engineer crop plants genetically. Here we also show that conventional genetic transformation techniques, via in vitro plant regeneration systems, still represent an unavoidable part of the high-throughput technology chain of molecular breeding.

  4. Conversion of a complete denture to a provisional implant-supported, screw-retained fixed prosthesis for immediate loading of a completely edentulous arch.

    Science.gov (United States)

    Kammeyer, Greg; Proussaefs, Periklis; Lozada, Jaime

    2002-05-01

    This article describes the fabrication of a provisional implant-supported, screw-retained restoration for immediate loading of a completely edentulous arch. The technique can be applied to patients with partially edentulous arches as well. Until immediate loading of dental implants becomes a well-documented treatment modality, the described method should not be applied on a routine basis or without careful evaluation.

  5. Immediate placement and provisionalization of maxillary anterior single implant with guided bone regeneration, connective tissue graft, and coronally positioned flap procedures.

    Science.gov (United States)

    Waki, Tomonori; Kan, Joseph Y K

    2016-01-01

    Immediate implant placement and provisionalization in the esthetic zone have been documented with success. The benefit of immediate implant placement and provisionalization is the preservation of papillary mucosa. However, in cases with osseous defects presenting on the facial bony plate, immediate implant placement procedures have resulted in facial gingival recession. Subepithelial connective tissue grafts for immediate implant placement and provisionalization procedures have been reported with a good esthetic outcome. Biotype conversion around implants with subepithelial connective tissue grafts have been advocated, and the resulting tissues appear to be more resistant to recession. The dimensions of peri-implant mucosa in a thick biotype were significantly greater than in a thin biotype. Connective tissue graft with coronally positioned flap procedures on natural teeth has also been documented with success. This article describes a technique combining immediate implant placement, provisionalization, guided bone regeneration (GBR), connective tissue graft, and a coronally positioned flap in order to achieve more stable peri-implant tissue in facial osseous defect situations.

  6. Documentation to the NCES Common Core of Data Public Elementary/Secondary School Universe Survey: School Year 2011-12. Provisional Version 1a. NCES 2014-100

    Science.gov (United States)

    Keaton, Patrick

    2013-01-01

    The documentation for this provisional version 1a file of the National Center for Education Statistics' (NCES) Common Core of Data (CCD) Public Elementary/Secondary School Universe Survey for SY 2011-12, contains a brief description of the data collection, along with information required to understand and access the data file. The SY 2011-12…

  7. Documentation to the NCES Common Core of Data Local Education Agency Universe Survey: School Year 2011-12. Provisional Version 1a. NCES 2014-035

    Science.gov (United States)

    Keaton, Patrick

    2014-01-01

    This documentation is for the provisional version 1a file of the National Center for Education Statistics' (NCES) Common Core of Data (CCD) Local Education Agency (LEA) Universe Survey for SY 2011-12. It contains a brief description of the data collection, along with information required to understand and access the data file. The CCD is a…

  8. La protección cautelar en el contencioso administrativo colombiano: hacia un modelo de justicia provisional

    Directory of Open Access Journals (Sweden)

    Daniel Castaño Parra

    2010-12-01

    Full Text Available Siguiendo de cerca las elaboraciones teóricas que se han gestado en otras latitudes para justificar la tutela cautelar como una modalidad de justicia provisional en razón del estrecho vínculo que existe entre ésta y la tutela judicial efectiva, se intentará extrapolar dicho razonamiento al derecho positivo colombiano para caracterizar a la protección cautelar como una auténtica concreción del derecho a la justicia consagrado en los artículos 8.1 y 25 de la Convención Americana sobre Derechos Humanos, y en los artículos 29 y 229 de la Carta Política de 1991.

  9. The effect of placement of glass fibers and aramid fibers on the fracture resistance of provisional restorative materials.

    Science.gov (United States)

    Saygili, Gülbin; Sahmali, Sevil M; Demirel, Figen

    2003-01-01

    The fracture resistance of provisional restorations is an important concern for the restorative dentist. The fracture resistance of a material is directly related to its transverse strength. Six specimens of similar dimensions were prepared from three resins (PMMA, PEMA and BIS acryl-composite). The resins were reinforced with glass and aramid fibers. The samples were tested immediately after the material set, following seven days of wet storage using three-point compression loading. The results were analyzed with an analysis of variance (ANOVA). Fracture resistance of the specimens was statistically different (p fibers showed higher transverse strength (149.82 MPa). The fiber reinforcement of resin materials increased the strength values (20-50%). Within the limitations of this study, the transverse strengths of PMMA, PEMA and BIS acryl-resin composites were improved after reinforcement with glass and aramid fibers.

  10. Immediate loading of definitive implants in the edentulous mandible using a fixed provisional prosthesis: The denture conversion technique.

    Science.gov (United States)

    Misch, Craig M

    2004-09-01

    This article presents a clinical technique for immediate implant loading in the completely edentulous mandible. The protocol recommends the placement of 4 to 5 root-form implants in the anterior mandible between the mental foramina. Upon insertion the implants must have favorable primary stability. Abutments are added to the implants and the patient's lower denture is converted into an immediate load provisional fixed prosthesis. The denture conversion technique has been shown to provide predictable results for immediate implant loading in the edentulous mandible. The final prosthesis is fabricated upon integration of the implants in 3 months. The denture conversion technique offers several advantages because it may be used with most commercially available implant systems and it incorporates conventional implant components. Guidelines for patient selection, presurgical preparation, implant surgery, prosthesis fabrication, and postoperative care are reviewed.

  11. Clinical outcomes following bioresorbable scaffold implantation for bifurcation lesions: Overall outcomes and comparison between provisional and planned double stenting strategy.

    Science.gov (United States)

    Kawamoto, Hiroyoshi; Latib, Azeem; Ruparelia, Neil; Miyazaki, Tadashi; Sticchi, Alessandro; Naganuma, Toru; Sato, Katsumasa; Figini, Filippo; Chieffo, Alaide; Carlino, Mauro; Montorfano, Matteo; Colombo, Antonio

    2015-10-01

    The aim of this study was to investigate clinical outcomes of patients treated with a provisional stenting (PS) versus a double stenting (DS) strategy for coronary bifurcation lesions with bioresorbable scaffolds (BRS). There are limited data available with regards to outcomes following BRS implantation for bifurcation lesions. A total of 132 bifurcation lesions treated with BRS between 2012 and 2014 were analyzed. Of the total of 132 bifurcation lesions, 10 lesions were treated without crossover stenting. 99 lesions (81%) were treated with a PS strategy and 23 lesions (19%) with a DS strategy. The DS group consisted of patients with a greater number of true bifurcation lesions (PS 52.0% vs. DS 91.3%: P strategy was employed. Larger studies are eagerly awaited to determine longer-term follow-up of this treatment strategy. © 2015 Wiley Periodicals, Inc.

  12. Antimicrobial Tolerance in Biofilms

    Science.gov (United States)

    Stewart, Philip S.

    2015-01-01

    The tolerance of microorganisms in biofilms to antimicrobial agents is examined through a meta-analysis of literature data. A numerical tolerance factor comparing the rates of killing in the planktonic and biofilm states is defined to provide a quantitative basis for the analysis. Tolerance factors for biocides and antibiotics range over three orders of magnitude. This variation is not explained by taking into account the molecular weight of the agent, the chemistry of the agent, the substratum material, or the speciation of the microorganisms. Tolerance factors do depend on the areal cell density of the biofilm at the time of treatment and on the age of the biofilm as grown in a particular experimental system. This suggests that there is something that happens during biofilm maturation, either physical or physiological, that is essential for full biofilm tolerance. Experimental measurements of antimicrobial penetration times in biofilms range over orders of magnitude, with slower penetration (>12 min) observed for reactive oxidants and cationic molecules. These agents are retarded through the interaction of reaction, sorption, and diffusion. The specific physiological status of microbial cells in a biofilm contributes to antimicrobial tolerance. A conceptual framework for categorizing physiological cell states is discussed in the context of antimicrobial susceptibility. It is likely that biofilms harbor cells in multiple states simultaneously (e.g., growing, stress-adapted, dormant, inactive) and that this physiological heterogeneity is an important factor in the tolerance of the biofilm state. PMID:26185072

  13. 50 CFR 259.34 - Minimum and maximum deposits; maximum time to deposit.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Minimum and maximum deposits; maximum time to deposit. 259.34 Section 259.34 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL... Capital Construction Fund Agreement § 259.34 Minimum and maximum deposits; maximum time to deposit. (a...

  14. Fracture strength and failure mode of maxillary implant-supported provisional single crowns: a comparison of composite resin crowns fabricated directly over PEEK abutments and solid titanium abutments.

    Science.gov (United States)

    Santing, Hendrik Jacob; Meijer, Henny J A; Raghoebar, Gerry M; Özcan, Mutlu

    2012-12-01

    Polyetheretherketone (PEEK) temporary abutments have been recently introduced for making implant-supported provisional single crowns. Little information is available in the dental literature on the durability of provisional implant-supported restorations. The objectives of this study were to evaluate the fracture strength of implant-supported composite resin crowns on PEEK and solid titanium temporary abutments, and to analyze the failure types. Three types of provisional abutments, RN synOcta Temporary Meso Abutment (PEEK; Straumann), RN synOcta Titanium Post for Temporary Restorations (Straumann), and Temporary Abutment Engaging NobRplRP (Nobel Biocare) were used, and provisional screw-retained crowns using composite resin (Solidex) were fabricated for four different locations in the maxilla. The specimens were tested in a universal testing machine at a crosshead speed of 1 mm/minute until fracture occurred. The failure types were analyzed and further categorized as irreparable (Type 1) or reparable (Type 2). No significant difference was found between different abutment types. Only for the position of the maxillary central incisor, composite resin crowns on PEEK temporary abutments showed significantly lower (p resin crowns (75 out of 104), followed by screw loosening (18 out of 104). According to reparability, the majority of the specimens were classified as Type 1 (82 out of 104). Type 2 failures were not often observed (22 out of 104). Provisional crowns on PEEK abutments showed similar fracture strength as titanium temporary abutments except for central incisors. Maxillary right central incisor composite resin crowns on PEEK temporary abutments fractured below the mean anterior masticatory loading forces reported to be approximately 206 N. © 2010 Wiley Periodicals, Inc.

  15. Inequality, Tolerance, and Growth

    DEFF Research Database (Denmark)

    Bjørnskov, Christian

    2004-01-01

    This paper argues for the importance of individuals' tolerance of inequality for economic growth. By using the political ideology of governments as a measure of revealed tolerance of inequality, the paper shows that controlling for ideology improves the accuracy with which the effects of inequali...... are measured. Results show that inequality reduces growth but more so in societies where people perceive it as being relatively unfair. Further results indicate that legal quality and social trust are likely transmission channels for the effects of inequality.......This paper argues for the importance of individuals' tolerance of inequality for economic growth. By using the political ideology of governments as a measure of revealed tolerance of inequality, the paper shows that controlling for ideology improves the accuracy with which the effects of inequality...

  16. Inequality, Tolerance, and Growth

    DEFF Research Database (Denmark)

    Bjørnskov, Christian

    This paper argues for the importance of individuals' tolerance of inequality for economic growth. By using the political ideology of governments as a measure of revealed tolerance of inequality, the paper shows that controlling for ideology improves the accuracy with which the effects of inequali...... are measured. Results show that inequality reduces growth but more so in societies where people perceive it as being relatively unfair. Further results indicate that legal quality and social trust are likely transmission channels for the effects of inequality.......This paper argues for the importance of individuals' tolerance of inequality for economic growth. By using the political ideology of governments as a measure of revealed tolerance of inequality, the paper shows that controlling for ideology improves the accuracy with which the effects of inequality...

  17. [INABILITY TO TOLERATE COSMETICS].

    Science.gov (United States)

    Piérard, G E; Piérard-Franchimont, C

    2016-05-01

    Inability to tolerate cosmetics can result from distinct mechanisms which appear as the so-called sensitive skin corresponding to one aspect of invisible dermatosis, or which corresponds to manifestations of a contact allergic or irritation dermatitis.

  18. Maximum daily rainfall in South Korea

    Indian Academy of Sciences (India)

    sponding datasets are described in section 2. The data used are the annual maximum daily rainfall from 1961 to 2001. The models and the fitting procedures are described in section 3. We use the method of maximum likelihood for estimation and the profile likelihood method for the corresponding confidence intervals.

  19. Location specific forecasting of maximum and minimum ...

    Indian Academy of Sciences (India)

    But, accurate forecasting of surface param- eters, particularly maximum and minimum tem- peratures over India, is a difficult task due to. Keywords. Statistical bias correction; location specific forecast; DMO; Numerical Weather Prediction; maximum and minimum temperature forecast. J. Earth Syst. Sci. 123, No. 5, July 2014 ...

  20. 24 CFR 200.15 - Maximum mortgage.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Maximum mortgage. 200.15 Section... Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Eligible Mortgage § 200.15 Maximum mortgage. Mortgages must not...

  1. Modelling maximum canopy conductance and transpiration in ...

    African Journals Online (AJOL)

    There is much current interest in predicting the maximum amount of water that can be transpired by Eucalyptus trees. It is possible that industrial waste water may be applied as irrigation water to eucalypts and it is important to predict the maximum transpiration rates of these plantations in an attempt to dispose of this ...

  2. Duality of Maximum Entropy and Minimum Divergence

    Directory of Open Access Journals (Sweden)

    Shinto Eguchi

    2014-06-01

    Full Text Available We discuss a special class of generalized divergence measures by the use of generator functions. Any divergence measure in the class is separated into the difference between cross and diagonal entropy. The diagonal entropy measure in the class associates with a model of maximum entropy distributions; the divergence measure leads to statistical estimation via minimization, for arbitrarily giving a statistical model. The dualistic relationship between the maximum entropy model and the minimum divergence estimation is explored in the framework of information geometry. The model of maximum entropy distributions is characterized to be totally geodesic with respect to the linear connection associated with the divergence. A natural extension for the classical theory for the maximum likelihood method under the maximum entropy model in terms of the Boltzmann-Gibbs-Shannon entropy is given. We discuss the duality in detail for Tsallis entropy as a typical example.

  3. Field-based methods for evaluating the annual maximum specific conductivity tolerated by freshwater invertebrates

    Data.gov (United States)

    U.S. Environmental Protection Agency — Data includes chemical and biological samples from Ecoregion 69 in West Virginia. eco69_dupchem.csv: 1. Station-year with at least 6 conductivity samples, one in the...

  4. Upward ant distribution shift corresponds with minimum, not maximum, temperature tolerance

    Science.gov (United States)

    Robert J. Warren; Lacy. Chick

    2013-01-01

    Rapid climate change may prompt species distribution shifts upward and poleward, but species movement in itself is not sufficient to establish climate causation. Other dynamics, such as disturbance history, may prompt species distribution shifts resembling those expected from rapid climate change. Links between species distributions, regional climate trends and...

  5. Fault-tolerant design

    CERN Document Server

    Dubrova, Elena

    2013-01-01

    This textbook serves as an introduction to fault-tolerance, intended for upper-division undergraduate students, graduate-level students and practicing engineers in need of an overview of the field.  Readers will develop skills in modeling and evaluating fault-tolerant architectures in terms of reliability, availability and safety.  They will gain a thorough understanding of fault tolerant computers, including both the theory of how to design and evaluate them and the practical knowledge of achieving fault-tolerance in electronic, communication and software systems.  Coverage includes fault-tolerance techniques through hardware, software, information and time redundancy.  The content is designed to be highly accessible, including numerous examples and exercises.  Solutions and powerpoint slides are available for instructors.   ·         Provides textbook coverage of the fundamental concepts of fault-tolerance; ·         Describes a variety of basic techniques for achieving fault-toleran...

  6. Retinal-image quality and maximum disparity

    Science.gov (United States)

    Castro, José J.; Jiménez, J. R.; Ortiz, Carolina; Alarcón, Aixa

    2010-01-01

    The aim of this paper is to evaluate the role of interocular differences in retinal-image quality in stereoscopic depth perception. To characterize retinal-image quality, we took the Strehl ratio from a double-pass device. Stereopsis was quantified through maximum disparity using random-dot stereograms (RDS). Data were taken for 25 observers with ages ranging from 21 to 61 years. The results show a significant correlation between maximum disparity and interocular differences in the Strehl ratio: the lower interocular differences, the higher maximum disparity. No significant dependence with age was found.

  7. Gyro-based Maximum-Likelihood Thruster Fault Detection and Identification

    Science.gov (United States)

    Wilson, Edward; Lages, Chris; Mah, Robert; Clancy, Daniel (Technical Monitor)

    2002-01-01

    When building smaller, less expensive spacecraft, there is a need for intelligent fault tolerance vs. increased hardware redundancy. If fault tolerance can be achieved using existing navigation sensors, cost and vehicle complexity can be reduced. A maximum likelihood-based approach to thruster fault detection and identification (FDI) for spacecraft is developed here and applied in simulation to the X-38 space vehicle. The system uses only gyro signals to detect and identify hard, abrupt, single and multiple jet on- and off-failures. Faults are detected within one second and identified within one to five accords,

  8. 5 CFR 1600.22 - Maximum contributions.

    Science.gov (United States)

    2010-01-01

    ... 1600.22 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD EMPLOYEE CONTRIBUTION ELECTIONS AND CONTRIBUTION ALLOCATIONS Program of Contributions § 1600.22 Maximum contributions. (a) Regular employee contributions. A participant's regular TSP contributions are subject the following limitations: (1...

  9. Recursive utility using the stochastic maximum principle

    National Research Council Canada - National Science Library

    Aase, Knut K

    2016-01-01

    .... We use the stochastic maximum principle to analyze the model. This method uses forward/backward stochastic differential equations, and works when the economy is not Markovian, which can be the case with recursive utility...

  10. Maximum phytoplankton concentrations in the sea

    DEFF Research Database (Denmark)

    Jackson, G.A.; Kiørboe, Thomas

    2008-01-01

    A simplification of plankton dynamics using coagulation theory provides predictions of the maximum algal concentration sustainable in aquatic systems. These predictions have previously been tested successfully against results from iron fertilization experiments. We extend the test to data collect...

  11. The maximum flow in dynamic networks

    Directory of Open Access Journals (Sweden)

    Maria A. Fonoberova

    2005-01-01

    Full Text Available The dynamic maximum flow problem that generalizes the static maximum flow problem is formulated and studied. We consider the problem on a network with capacities depending on time, fixed transit times on the arcs, and a given time horizon. The corresponding algorithm to solve this problem is proposed and some details concerning its complexity are discussed. Mathematics Subject Classification 2000: 90B10, 90C35, 90C27.

  12. Maximum Entropy Approaches to Living Neural Networks

    Directory of Open Access Journals (Sweden)

    John M. Beggs

    2010-01-01

    Full Text Available Understanding how ensembles of neurons collectively interact will be a key step in developing a mechanistic theory of cognitive processes. Recent progress in multineuron recording and analysis techniques has generated tremendous excitement over the physiology of living neural networks. One of the key developments driving this interest is a new class of models based on the principle of maximum entropy. Maximum entropy models have been reported to account for spatial correlation structure in ensembles of neurons recorded from several different types of data. Importantly, these models require only information about the firing rates of individual neurons and their pairwise correlations. If this approach is generally applicable, it would drastically simplify the problem of understanding how neural networks behave. Given the interest in this method, several groups now have worked to extend maximum entropy models to account for temporal correlations. Here, we review how maximum entropy models have been applied to neuronal ensemble data to account for spatial and temporal correlations. We also discuss criticisms of the maximum entropy approach that argue that it is not generally applicable to larger ensembles of neurons. We conclude that future maximum entropy models will need to address three issues: temporal correlations, higher-order correlations, and larger ensemble sizes. Finally, we provide a brief list of topics for future research.

  13. pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery.

    Science.gov (United States)

    Varma, Manthena V; Gardner, Iain; Steyn, Stefanus J; Nkansah, Paul; Rotter, Charles J; Whitney-Pickett, Carrie; Zhang, Hui; Di, Li; Cram, Michael; Fenner, Katherine S; El-Kattan, Ayman F

    2012-05-07

    The Biopharmaceutics Classification System (BCS) is a scientific framework that provides a basis for predicting the oral absorption of drugs. These concepts have been extended in the Biopharmaceutics Drug Disposition Classification System (BDDCS) to explain the potential mechanism of drug clearance and understand the effects of uptake and efflux transporters on absorption, distribution, metabolism, and elimination. The objective of present work is to establish criteria for provisional biopharmaceutics classification using pH-dependent passive permeability and aqueous solubility data generated from high throughput screening methodologies in drug discovery settings. The apparent permeability across monolayers of clonal cell line of Madin-Darby canine kidney cells, selected for low endogenous efflux transporter expression, was measured for a set of 105 drugs, with known BCS and BDDCS class. The permeability at apical pH 6.5 for acidic drugs and at pH 7.4 for nonacidic drugs showed a good correlation with the fraction absorbed in human (Fa). Receiver operating characteristic (ROC) curve analysis was utilized to define the permeability class boundary. At permeability ≥ 5 × 10(-6) cm/s, the accuracy of predicting Fa of ≥ 0.90 was 87%. Also, this cutoff showed more than 80% sensitivity and specificity in predicting the literature permeability classes (BCS), and the metabolism classes (BDDCS). The equilibrium solubility of a subset of 49 drugs was measured in pH 1.2 medium, pH 6.5 phosphate buffer, and in FaSSIF medium (pH 6.5). Although dose was not considered, good concordance of the measured solubility with BCS and BDDCS solubility class was achieved, when solubility at pH 1.2 was used for acidic compounds and FaSSIF solubility was used for basic, neutral, and zwitterionic compounds. Using a cutoff of 200 μg/mL, the data set suggested a 93% sensitivity and 86% specificity in predicting both the BCS and BDDCS solubility classes. In conclusion, this study identified

  14. Simulation of aspheric tolerance with polynomial fitting

    Science.gov (United States)

    Li, Jing; Cen, Zhaofeng; Li, Xiaotong

    2018-01-01

    The shape of the aspheric lens changes caused by machining errors, resulting in a change in the optical transfer function, which affects the image quality. At present, there is no universally recognized tolerance criterion standard for aspheric surface. To study the influence of aspheric tolerances on the optical transfer function, the tolerances of polynomial fitting are allocated on the aspheric surface, and the imaging simulation is carried out by optical imaging software. Analysis is based on a set of aspheric imaging system. The error is generated in the range of a certain PV value, and expressed as a form of Zernike polynomial, which is added to the aspheric surface as a tolerance term. Through optical software analysis, the MTF of optical system can be obtained and used as the main evaluation index. Evaluate whether the effect of the added error on the MTF of the system meets the requirements of the current PV value. Change the PV value and repeat the operation until the acceptable maximum allowable PV value is obtained. According to the actual processing technology, consider the error of various shapes, such as M type, W type, random type error. The new method will provide a certain development for the actual free surface processing technology the reference value.

  15. In vitro evaluation of the flexural properties of All-on-Four provisional fixed denture base resin partially reinforced with fibers.

    Science.gov (United States)

    Li, Bei Bei; Xu, Jia Bin; Cui, Hong Yan; Lin, Ye; Di, Ping

    2016-01-01

    The aim of this study was to assess the effects of partial carbon or glass fiber reinforcement on the flexural properties of All-on-Four provisional fixed denture base resin. The carbon or glass fibers were woven (3% by weight) together in three strands and twisted and tightened between the two abutments in a figure-of-"8" pattern. Four types of specimens were fabricated for the three-point loading test. The interface between the denture base resin and fibers was examined using scanning electron microscopy (SEM). Reinforcement with carbon or glass fibers between two abutments significantly increased the flexural strength and flexural modulus. SEM revealed relatively continuous contact between the fibers and acrylic resin. The addition of carbon or glass fibers between two abutments placed on All-on-Four provisional fixed denture base resin may be clinically effective in preventing All-on-Four denture fracture and can provide several advantages for clinical use.

  16. Comparison of temperature rise in pulp chamber during polymerization of materials used for direct fabrication of provisional restorations: An in-vitro study.

    Science.gov (United States)

    Khajuria, Rajat R; Madan, Ravi; Agarwal, Swatantra; Gupta, Reecha; Vadavadgi, Sunil V; Sharma, Vikas

    2015-01-01

    The purpose is to compare temperature rise in the pulp chamber during fabrication of provisional crowns using different materials and on different types of teeth using direct technique. An extracted, sound, caries free maxillary central incisor and a mandibular molar were selected for the study and crown preparations of all ceramic and all metal were done on central incisor and mandibular molar, respectively. Materials tested were DPI tooth molding self-curing material and protemp-4. Addition silicone putty was used as a matrix and 80 provisional crowns were fabricated, of which 40 were on central incisor and 40 on mandibular molar. Depending on the type of material used, they were further divided into two subgroups: Each comprising 20 provisional crowns. Temperature readings were recorded using K type of thermocouple with 0.1°C precision digital thermometer. Analysis of variance, Tukey honest significant difference and Kruskall-Wallis H-test. Statistically significant difference exists between two materials tested on the basis of peak temperature achieved and time taken by a particular material to reach peak temperature. Peak temperature achieved was highest for provisional crowns with DPI tooth molding self-curing material on maxillary central incisor (40.39 + 0.46), followed by DPI tooth molding self-curing material on mandibular molar (40.03 + 0.32), protemp-4 on maxillary central incisor (39.46 + 0.26) and least with protemp-4 on mandibular molar (39.09 + 0.33). The time taken to reach peak temperature was almost double in DPI tooth molding self-curing material (5 min) than in protemp-4. Polymethyl methacrylate resin produced higher intra-pulpal rise when compared to newer generation bis-acrylic composite.

  17. The effects of desensitizing resin, resin sealing, and provisional cement on the bond strength of dentin luted with self-adhesive and conventional resincements.

    Science.gov (United States)

    Sailer, Irena; Oendra, Andrea E Hernandez; Stawarczyk, Bogna; Hämmerle, Christoph H F

    2012-04-01

    Self-adhesive resin cements were designed to bond without any pretreatment of dentin. However, pretreatments such as the application of desensitizing resin or the resin sealing of dentin with priming/bonding solutions might influence the bonding quality of these self-adhesive resin cements. Little is known about the effect of dentin pretreatment on the bond quality of self-adhesive resin cements. This study evaluated whether dentin desensitizing or sealing methods influenced the shear bond strength of 1 self-adhesive and 2 conventional resin cements. One-hundred and eighty human molars were assigned to 5 different pretreatment groups: 1) freshly ground dentin, 2) glutaraldehyde/hydroxyethylmethacrylate (HEMA) desensitized dentin (Gluma), 3) contamination of desensitized dentin with provisional cement, 4) sealed dentin (dual bonding technique), and 5) contamination of sealed dentin with provisional cement. The shear bond strength of a self-adhesive resin cement (RelyX Unicem; RXU) and 2 conventional resin cements (Variolink II; VAR, Panavia 21; PAN) was assessed for each pretreatment group (n=12 per cement types). Two-way ANOVA and 1-way ANOVA together with the post hoc Tukey multiple comparison (α=.05) were performed. On freshly ground dentin, PAN exhibited the highest shear bond strength values (Pdentin (Pdentin increased the bond strength of RXU but had no significant effect on VAR or PAN. RXU exhibited the highest mean bond strength after the contamination of resin-sealed dentin by provisional cement. Glutaraldehyde/HEMA treatment and resin sealing of dentin have a beneficial effect on the shear bond strength of self-adhesive resin cement (RXU). Contamination of dentin with provisional cement has no influence on the bond strength of the self-adhesive resin cement (RXU) or VAR but lowered the bond strength of PAN. Copyright © 2012 The Editorial Council of the Journal of Prosthetic Dentistry. Published by Mosby, Inc. All rights reserved.

  18. Estudio descriptivo de la utilización de los espacios deportivos municipales: perspectiva en el uso de un sistema provisional de indicadores.

    OpenAIRE

    Cuenca Ereú, Federico Ignacio

    2016-01-01

    Este estudio consiste en el desarrollo de un sistema provisional de indicadores que permita la descripción de aspectos evaluativos en relación al uso de instalaciones deportivas. Para su elaboración se han tenido en cuenta los datos suministrados por el Departamento de Deportes del Ayuntamiento de Vitoria-Gasteiz en relación a sus instalaciones de tenis y pádel.

  19. Effects of surface treatment and artificial aging on the shear bond strength of orthodontic brackets bonded to four different provisional restorations.

    Science.gov (United States)

    Al Jabbari, Youssef S; Al Taweel, Sara M; Al Rifaiy, Mohammed; Alqahtani, Mohammed Q; Koutsoukis, Theodoros; Zinelis, Spiros

    2014-07-01

    To evaluate the combined effects of material type, surface treatment, and thermocycling on the bond strength of orthodontic brackets to materials used for the fabrication of provisional crowns. Four materials were included in this study (ProTemp, Trim Plus, Trim II, and Superpont C+B). Sixty cylindrical specimens (1 × 3 cm) were prepared from each material and equally divided into three groups. The first group was ground with silica carbide paper, the second was polished with pumice, and the last group was sandblasted with 50-µm aluminum oxide particles. Stainless-steel maxillary central incisor brackets (Victory Series, 3M) were bonded to the provisional material specimens with Transbond XT light-cured composite resin, and half of the specimens from each group were thermocycled 500 times in 5°C and 55°C water baths. Then the brackets were debonded with shear testing, and the results were statistically analyzed by three-way analysis of variance and Tukey's multiple-comparison tests at α  =  0.05. Adhesive Remnant Index (ARI) was also identified. Before and after thermocycling, ProTemp materials showed the highest shear bond strength with orthodontic brackets (10.3 and 13.1 MPa, respectively). The statistical analysis indicated an interaction among the three independent variables (P < .05) and statistically significant differences in bond strength among provisional materials (P < .001), surface treatments (P < .001), and thermocycling (P < .05). According to the ARI, most groups demonstrated adhesive failure. The provisional material type, surface treatment, and artificial aging have a significant effect on bond strength. Sandblasting treatment exerts a beneficial effect on shear bond strength.

  20. Provisional Tic Disorder: What to tell parents when their child first starts ticcing [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Kevin J Black

    2016-04-01

    Full Text Available The child with recent onset of tics is a common patient in a pediatrics or child neurology practice. If the child’s first tic was less than a year in the past, the diagnosis is usually Provisional Tic Disorder (PTD. Published reviews by experts reveal substantial consensus on prognosis in this situation: the tics will almost always disappear in a few months, having remained mild while they lasted. Surprisingly, however, the sparse existing data may not support these opinions. PTD may have just as much importance for science as for clinical care. It provides an opportunity to prospectively observe the spontaneous remission of tics. Such prospective studies may aid identification of genes or biomarkers specifically associated with remission rather than onset of tics. A better understanding of tic remission may also suggest novel treatment strategies for Tourette syndrome, or may lead to secondary prevention of tic disorders. This review summarizes the limited existing data on the epidemiology, phenomenology, and outcome of PTD, highlights areas in which prospective study is sorely needed, and proposes that tic disorders may completely remit much less often than is generally believed.

  1. Evaluation of the flexural strength and microhardness of provisional crown and bridge materials fabricated by different methods.

    Science.gov (United States)

    Digholkar, Shruti; Madhav, V N V; Palaskar, Jayant

    2016-01-01

    The purpose of this study was to evaluate and compare the flexural strength and microhardness of provisional restorative materials fabricated utilizing rapid prototyping (RP), Computer Assisted Designing and Computer Assisted Milling (CAD-CAM) and conventional method. Twenty specimens of dimensions 25 mm × 2 mm × 2 mm (ADA-ANSI specification #27) were fabricated each using: (1) Three dimensional (3D) printed light-cured micro-hybrid filled composite by RP resin group, (2) a milled polymethyl methacrylate (CH) using CAD-CAM (CC resin group), and (3) a conventionally fabricated heat activated polymerized CH resin group. Flexural strength and microhardness were measured and values obtained were evaluated. The measured mean flexural strength values (MegaPascals) were 79.54 (RP resin group), 104.20 (CC resin group), and 95.58 (CH resin group). The measured mean microhardness values (Knoop hardness number) were 32.77 (RP resin group), 25.33 (CC resin group), and 27.36 (CH resin group). The analysis of variance (ANOVA) test shows that there is statistically significant difference in the flexural strength values of the three groups (P microhardness values of the three groups was statistically significant according to ANOVA as well as the intergroup comparison done using the Tukey's HSD (post hoc) test (P microhardness.

  2. 3HP tolerance

    DEFF Research Database (Denmark)

    2014-01-01

    Cells and cell cultures are provided that have improved tolerance to 3-hydroxypropionic acid (3HP). Genetic modifications to provide a mutated or overexpressed SFA1 gene or other enhancement of 3HP detoxification via a glutathione- dependent dehydrogenase reaction, including medium supplementation...... with glutathione, may be combined with a 3HP producing metabolic pathway....

  3. COMMUNICATIVE TOLERANCE DISCOURSE

    Directory of Open Access Journals (Sweden)

    B. R. Mogilevich

    2016-01-01

    Full Text Available Tolerance, communication and theme repertoire are communicative discourse components. The dialogue relations of communicators in the process of their life activity reflect where socio-cultural specific characteristics. The speech structure of communication adherence to speech frames and the Principles of Cooperation and Politeness as indicators of tolerance and empathy. Language speakers share one discourse code as a condition of successful communication. Discourse activity represents information exchange in the process of achieving various socio-cultural and cognitive goals. Tolerance, in its term, includes communicators` mutual empathy as the main conditions of communication success. Communicative tolerance is presented as communicative behavior prescriptions, specific for various socio-cultural areas. Theme repertoire phenomenon means shared knowledge and interpretation of all social communication participants. The combination of global context and local ones acquire special significance. Contextual limitations reflect socio-cultural specifics and are determined by the existence of behavior stereotypes and their evaluation. Thus, each discourse component contributes to achieving social-communication goals. 

  4. Optimizing anterior esthetics of a single-tooth implant through socket augmentation and immediate provisionalization: A case report with 7-year follow-up

    Directory of Open Access Journals (Sweden)

    Po-Sung Fu

    2012-10-01

    Full Text Available Tooth extraction inevitably accompanies alveolar ridge resorption with loss of pre-existing tissue morphology. Replacing missing teeth with dental implants has become popular, but restoring anterior teeth with implant-supported restorations is a technique-sensitive task and poses challenges for dentists. With the progress of implant dentistry, the demand for optimal esthetics has become linked with the desire for faster, easier techniques that shorten treatment time and also satisfy patients. Immediate provisionalization of a single-tooth implant provides significant benefits compared with traditional delayed protocols, such as aiding the contouring of peri-implant soft tissue and enhancing patient comfort and satisfaction. This article describes a meticulous approach to a hopeless maxillary central incisor with root fracture. The defect in the extraction socket was reconstructed using autogenous bone harvested from the chin. Four months later, an implant was installed and immediately restored. After another healing period of 6 months, the peri-implant soft tissue had been shaped and matured according to the contours of the provisional restoration. The emergence profile was used to duplicate the definitive restoration. Peri-implant esthetics was achieved through socket augmentation and immediate provisionalization of the implant. This treatment modality attained predictable and maintainable outcomes, both functionally and esthetically.

  5. Instalación inmediata de prótesis provisionales en la reapertura de implantes Immediate instalation of provisional protheses in implant reopening

    Directory of Open Access Journals (Sweden)

    Alejandro Munõz Chávez

    2007-03-01

    Full Text Available El estudio de las técnicas para alcamzar una estética en el seguimiento anterior cuando se utilizan implantes osteointegrados es de gran importancia. Se realizó una revisión de la literatura con el objetivo de comparar la eficiencia y conveniencia de la instalación de prótesis provisionales inmediatamente en la reapertura de los implantes osteointegrados en relación con el tiempo establecido (uso de cicatrizadores estandarizados y cicatrizadores con perfil de emergencia arbitrado. La prótesis provisional inmediata en la fase de reapertura propicia la restauración del contorno de la encía más rápidamente cuando se compara con el uso de cicatrizadores sin necesidad de fases intermediarias.The study of techniques to reach aesthetics in the anterior region when using osseointegrated implants is of great importance. A literature review was made to compare effivciency and suitability of immediate provisionalization in re-opening of osseointegrated implants with respect to the set time (use of standardized cicatrizants and emergency profile cicatrizants. Immediate provisional denture in the phase of re-opening makes the restoration of the gingival contourn quicker when compared to the use of cicatrizants without intermediate phases required.

  6. Entropy generation: Minimum inside and maximum outside

    Science.gov (United States)

    Lucia, Umberto

    2014-02-01

    The extremum of entropy generation is evaluated for both maximum and minimum cases using a thermodynamic approach which is usually applied in engineering to design energy transduction systems. A new result in the thermodynamic analysis of the entropy generation extremum theorem is proved by the engineering approach. It follows from the proof that the entropy generation results as a maximum when it is evaluated by the exterior surroundings of the system and a minimum when it is evaluated within the system. The Bernoulli equation is analyzed as an example in order to evaluate the internal and external dissipations, in accordance with the theoretical results obtained.

  7. New times of maximum of CY Aquarii

    Science.gov (United States)

    Tuvikene, T.; Sterken, C.; Brogt, E.; Cont, D.; Henden, A.; Papadaki, C.; Volkov, I.; Wiedemair, C.

    2010-04-01

    We present a collection of 102 new times of maximum of the SX Phoenicis star CY Aquarii. These times, together with 20 times of maximum taken from the literature, lead to a new local linear ephemeris for 2003--2009 with a formally slightly shorter period than the one for 1996--2002. It will require at least another half decade of additional monitoring before any significant update to any model can be considered. Such monitoring should preferably occur at regular intervals, be done in a consistent photometric band, and at high time resolution.

  8. Maximum Entropy Learning with Deep Belief Networks

    Directory of Open Access Journals (Sweden)

    Payton Lin

    2016-07-01

    Full Text Available Conventionally, the maximum likelihood (ML criterion is applied to train a deep belief network (DBN. We present a maximum entropy (ME learning algorithm for DBNs, designed specifically to handle limited training data. Maximizing only the entropy of parameters in the DBN allows more effective generalization capability, less bias towards data distributions, and robustness to over-fitting compared to ML learning. Results of text classification and object recognition tasks demonstrate ME-trained DBN outperforms ML-trained DBN when training data is limited.

  9. Density estimation by maximum quantum entropy

    Energy Technology Data Exchange (ETDEWEB)

    Silver, R.N.; Wallstrom, T.; Martz, H.F.

    1993-11-01

    A new Bayesian method for non-parametric density estimation is proposed, based on a mathematical analogy to quantum statistical physics. The mathematical procedure is related to maximum entropy methods for inverse problems and image reconstruction. The information divergence enforces global smoothing toward default models, convexity, positivity, extensivity and normalization. The novel feature is the replacement of classical entropy by quantum entropy, so that local smoothing is enforced by constraints on differential operators. The linear response of the estimate is proportional to the covariance. The hyperparameters are estimated by type-II maximum likelihood (evidence). The method is demonstrated on textbook data sets.

  10. Revealing the Maximum Strength in Nanotwinned Copper

    DEFF Research Database (Denmark)

    Lu, L.; Chen, X.; Huang, Xiaoxu

    2009-01-01

    The strength of polycrystalline materials increases with decreasing grain size. Below a critical size, smaller grains might lead to softening, as suggested by atomistic simulations. The strongest size should arise at a transition in deformation mechanism from lattice dislocation activities to grain...... boundary–related processes. We investigated the maximum strength of nanotwinned copper samples with different twin thicknesses. We found that the strength increases with decreasing twin thickness, reaching a maximum at 15 nanometers, followed by a softening at smaller values that is accompanied by enhanced...

  11. Maximum entropy analysis of EGRET data

    DEFF Research Database (Denmark)

    Pohl, M.; Strong, A.W.

    1997-01-01

    EGRET data are usually analysed on the basis of the Maximum-Likelihood method \\cite{ma96} in a search for point sources in excess to a model for the background radiation (e.g. \\cite{hu97}). This method depends strongly on the quality of the background model, and thus may have high systematic...... uncertainties in region of strong and uncertain background like the Galactic Center region. Here we show images of such regions obtained by the quantified Maximum-Entropy method. We also discuss a possible further use of MEM in the analysis of problematic regions of the sky....

  12. Connection between maximum-work and maximum-power thermal cycles.

    Science.gov (United States)

    Gonzalez-Ayala, Julian; Arias-Hernandez, L A; Angulo-Brown, F

    2013-11-01

    A new connection between maximum-power Curzon-Ahlborn thermal cycles and maximum-work reversible cycles is proposed. This linkage is built through a mapping between the exponents of a class of heat transfer laws and the exponents of a family of heat capacities depending on temperature. This connection leads to the recovery of known results and to a wide and interesting set of results for a class of thermal cycles. Among other results it was found that it is possible to use analytically closed expressions for maximum-work efficiencies to calculate good approaches to maximum-power efficiencies. Behind the proposed connection is an interpretation of endoreversibility hypothesis. Additionally, we suggest that certain reversible maximum-work cycles depending on working substance can be used as reversible landmarks for FTT maximum-power cycles, which also depend on working substance properties.

  13. Hacia un inventario provisional de las tendencias en Bibliotecología y Ciencia de la Información = Towards a provisional inventory of trends in Library and Information Science.

    Directory of Open Access Journals (Sweden)

    Alejandro E. Parada

    2015-12-01

    Full Text Available Este trabajo se presentó como un documento de debate y reflexión en las 1º Jornadas Nacionales de Docentes e Investigadores Universitarios en Ciencia de la Información (DUCI, llevadas a cabo el 3 y 4 de septiembre de 2015 en la Biblioteca Nacional Mariano Moreno. En el texto se señalan, en forma preliminar y provisional, algunas de las perspectivas más importantes de la Bibliotecología y Ciencia de la Información (BCI. En este contexto se citan las siguientes: la crisis de la denominación propia de la identidad, el papel del liderazgo de la profesión en la Web 2.0, el tópico de la cogestión entre los bibliotecarios y los usuarios, las potencialidades de autorrepresentación y deliberación de las bibliotecas, las dimensiones tecnológicas, la construcción de la lingüística profesional, la importancia del análisis de dominio en la web semántica y sus relaciones con el lenguaje, la tendencia a la inclusión, la gestación de los portales de acceso abierto, el paradigma de la diversidad polimórfica, la dimensión teórica y de índole filosófica, entre otras muchas. Finalmente, se señala la trascendencia de la BCI como una disciplina de la pluralidad y diversidad virtual, y como un campo en estado de apertura para que los ciudadanos transformen la información en conocimiento = This work was presented as a document for debate and reflection in the 1º Jornadas Nacionales de Docentes e Investigadores Universitarios en Ciencia de la Información (DUCI held on 3rd and 4th September 2015 at the Biblioteca Nacional Mariano Moreno. The text indicates, in preliminary and provisional way, some of the most important perspectives of Library and Information Science. In this context, the following perspectives are mentioned: The crisis of the identity denomination, the role of leadership of the profession in the Web 2.0, the topic of co-management between librarians and users, the potential of self-representation and deliberation in

  14. Maximum potential preventive effect of hip protectors

    NARCIS (Netherlands)

    van Schoor, N.M.; Smit, J.H.; Bouter, L.M.; Veenings, B.; Asma, G.B.; Lips, P.T.A.M.

    2007-01-01

    OBJECTIVES: To estimate the maximum potential preventive effect of hip protectors in older persons living in the community or homes for the elderly. DESIGN: Observational cohort study. SETTING: Emergency departments in the Netherlands. PARTICIPANTS: Hip fracture patients aged 70 and older who

  15. 7 CFR 1778.11 - Maximum grants.

    Science.gov (United States)

    2010-01-01

    ... quantity of potable water, or an anticipated acute shortage or significant decline, cannot exceed $150,000... (CONTINUED) EMERGENCY AND IMMINENT COMMUNITY WATER ASSISTANCE GRANTS § 1778.11 Maximum grants. (a) Grants not to exceed $500,000 may be made to alleviate a significant decline in quantity or quality of water...

  16. Hard graphs for the maximum clique problem

    NARCIS (Netherlands)

    Hoede, C.

    1988-01-01

    The maximum clique problem is one of the NP-complete problems. There are graphs for which a reduction technique exists that transforms the problem for these graphs into one for graphs with specific properties in polynomial time. The resulting graphs do not grow exponentially in order and number.

  17. Maximum gain of Yagi-Uda arrays

    DEFF Research Database (Denmark)

    Bojsen, J.H.; Schjær-Jacobsen, Hans; Nilsson, E.

    1971-01-01

    Numerical optimisation techniques have been used to find the maximum gain of some specific parasitic arrays. The gain of an array of infinitely thin, equispaced dipoles loaded with arbitrary reactances has been optimised. The results show that standard travelling-wave design methods are not optimum....... Yagi–Uda arrays with equal and unequal spacing have also been optimised with experimental verification....

  18. Efficient Algorithms for the Maximum Sum Problems

    Directory of Open Access Journals (Sweden)

    Sung Eun Bae

    2017-01-01

    Full Text Available We present efficient sequential and parallel algorithms for the maximum sum (MS problem, which is to maximize the sum of some shape in the data array. We deal with two MS problems; the maximum subarray (MSA problem and the maximum convex sum (MCS problem. In the MSA problem, we find a rectangular part within the given data array that maximizes the sum in it. The MCS problem is to find a convex shape rather than a rectangular shape that maximizes the sum. Thus, MCS is a generalization of MSA. For the MSA problem, O ( n time parallel algorithms are already known on an ( n , n 2D array of processors. We improve the communication steps from 2 n − 1 to n, which is optimal. For the MCS problem, we achieve the asymptotic time bound of O ( n on an ( n , n 2D array of processors. We provide rigorous proofs for the correctness of our parallel algorithm based on Hoare logic and also provide some experimental results of our algorithm that are gathered from the Blue Gene/P super computer. Furthermore, we briefly describe how to compute the actual shape of the maximum convex sum.

  19. Global characterization of the Holocene Thermal Maximum

    NARCIS (Netherlands)

    Renssen, H.; Seppä, H.; Crosta, X.; Goosse, H.; Roche, D.M.V.A.P.

    2012-01-01

    We analyze the global variations in the timing and magnitude of the Holocene Thermal Maximum (HTM) and their dependence on various forcings in transient simulations covering the last 9000 years (9 ka), performed with a global atmosphere-ocean-vegetation model. In these experiments, we consider the

  20. Multi-Channel Maximum Likelihood Pitch Estimation

    DEFF Research Database (Denmark)

    Christensen, Mads Græsbøll

    2012-01-01

    In this paper, a method for multi-channel pitch estimation is proposed. The method is a maximum likelihood estimator and is based on a parametric model where the signals in the various channels share the same fundamental frequency but can have different amplitudes, phases, and noise characteristi...

  1. Neonatal Maximum Thigh Circumference Tape: An Alternative ...

    African Journals Online (AJOL)

    Conclusion: Using the cut-off values obtained, the neonates were categorized into three risk groups (“high risk”, “moderate risk”, and “low risk”), and a tricoloured MTC Tape was subsequently designed, using these inferences. Key words: Maximum thigh circumference, low birth weight, indicator. Nigerian Journal of ...

  2. Comparing maximum pressures in internal combustion engines

    Science.gov (United States)

    Sparrow, Stanwood W; Lee, Stephen M

    1922-01-01

    Thin metal diaphragms form a satisfactory means for comparing maximum pressures in internal combustion engines. The diaphragm is clamped between two metal washers in a spark plug shell and its thickness is chosen such that, when subjected to explosion pressure, the exposed portion will be sheared from the rim in a short time.

  3. 5 CFR 9701.312 - Maximum rates.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Maximum rates. 9701.312 Section 9701.312 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM (DEPARTMENT OF HOMELAND SECURITY-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES...

  4. Location specific forecasting of maximum and minimum ...

    Indian Academy of Sciences (India)

    Statistical bias correction; location specific forecast; DMO; Numerical Weather Prediction; maximum and minimum temperature forecast. Abstract. The output from Global Forecasting System (GFS) T574L64 operational at India Meteorological Department (IMD), New Delhi is used for obtaining location specific quantitative ...

  5. PARTICLE SWARM OPTIMIZATION BASED OF THE MAXIMUM ...

    African Journals Online (AJOL)

    2010-06-30

    Jun 30, 2010 ... systems from one hand and because of the instantaneous change of both insulation and temperature ... dealing accurately with these optimization problems and to overcome the incapacities of the traditional ... Series resistance RS, which gives a more accurate shape between the maximum power point ...

  6. Climate Change Impacts on Probable Maximum Precipitation

    Science.gov (United States)

    Kunkel, K.; Easterling, D. R.

    2011-12-01

    The estimation of the potential impacts of anthropogenic forcing of the climate system on extreme weather events relies heavily on the direct output of global and regional climate models, combined perhaps with extreme value statistical techniques. In this study, we use these tools along with physical and theoretical considerations to examine the potential impacts on Probable Maximum Precipitation estimates. Probable Maximum Precipitation (PMP) is the theoretically greatest depth of precipitation for a given duration that is physically possible over a particular drainage basin at a particular time of year. PMP values are used in the design of long-lived structures with lifetimes of many decades, such as dams. Climate change is an unavoidable consideration on those time scales. Many studies have documented an upward temporal trend in the frequency and intensity of extreme precipitation events. As the globe warms in response to increasing greenhouse gas concentrations, there is the potential for further changes in precipitation extremes. There are reasons why warming could lead to increased PMP values. One, the Clausius-Clapeyron relationship indicates that the saturation water vapor pressure increases with temperature; thus, precipitation-producing systems could have more "fuel" to precipitate. Two, warming may lead to an increase in the length of the convective season, when most of the extreme precipitation events occur. The methodology for estimation of PMP values has changed little over the last 30-40 years. The basic approach is to consider the factors that contribute to heavy precipitation and then consider the potential precipitation rates if all of those factors were simultaneously maximized. Convergence and vertical motion is one factor. Past work has assumed that there no empirical or satisfactory theoretical basis for assigning maximum values to this factor. The approach has been to use observed rainfall in notable storms as an indirect measure of maximum

  7. Abuse Tolerance Improvements

    Energy Technology Data Exchange (ETDEWEB)

    Orendorff, Christopher J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Nagasubramanian, Ganesan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Fenton, Kyle R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Allcorn, Eric [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    As lithium-ion battery technologies mature, the size and energy of these systems continues to increase (> 50 kWh for EVs); making safety and reliability of these high energy systems increasingly important. While most material advances for lithium-ion chemistries are directed toward improving cell performance (capacity, energy, cycle life, etc.), there are a variety of materials advancements that can be made to improve lithium-ion battery safety. Issues including energetic thermal runaway, electrolyte decomposition and flammability, anode SEI stability, and cell-level abuse tolerance continue to be critical safety concerns. This report highlights work with our collaborators to develop advanced materials to improve lithium-ion battery safety and abuse tolerance and to perform cell-level characterization of new materials.

  8. Fault Tolerant Control Systems

    DEFF Research Database (Denmark)

    Bøgh, S.A.

    failures. It is often feasible to increase availability for these control loops by designing the control system to perform on-line detection and reconfiguration in case of faults before the safety system makes a close-down of the process. A general development methodology is given in the thesis......This thesis considered the development of fault tolerant control systems. The focus was on the category of automated processes that do not necessarily comprise a high number of identical sensors and actuators to maintain safe operation, but still have a potential for improving immunity to component...... that carried the control system designer through the steps necessary to consider fault handling in an early design phase. It was shown how an existing control loop with interface to the plant wide control system could be extended with three additional modules to obtain fault tolerance: Fault detection...

  9. Helminths and immunological tolerance

    OpenAIRE

    Johnston, Chris J C; McSorley, Henry J; Anderton, Stephen M; Wigmore, Stephen J; Maizels, Rick M

    2014-01-01

    Current immunosuppression regimens for solid-organ transplantation have shown disappointing efficacy in the prevention of chronic allograft rejection and carry unacceptable risks including toxicity, neoplasia, and life-threatening infection. Achievement of immunological tolerance (long-term antigen unresponsiveness in an immunocompetent host) presents the exciting prospect of freedom from immunosuppression for transplant recipients. It is now 60 years since the first demonstration of immunolo...

  10. Toleration, Liberty and Privileges

    DEFF Research Database (Denmark)

    Simonton, Deborah

    2017-01-01

    Guilds are usually seen as the epitome of economic regulation and organization in early modern European towns. As organisations closely tied to the nominal male lifecycle, historians of women have tended to be chary of them and identified guilds as a key mechanism for restricting women’s access t...... to trade could depend on gaining tolerations, earning the liberty of the trade and using the liberties associated with it....

  11. Drought Tolerance in Wheat

    Science.gov (United States)

    Prodhan, Zakaria Hossain; Faruq, Golam

    2013-01-01

    Drought is one of the most important phenomena which limit crops' production and yield. Crops demonstrate various morphological, physiological, biochemical, and molecular responses to tackle drought stress. Plants' vegetative and reproductive stages are intensively influenced by drought stress. Drought tolerance is a complicated trait which is controlled by polygenes and their expressions are influenced by various environmental elements. This means that breeding for this trait is so difficult and new molecular methods such as molecular markers, quantitative trait loci (QTL) mapping strategies, and expression patterns of genes should be applied to produce drought tolerant genotypes. In wheat, there are several genes which are responsible for drought stress tolerance and produce different types of enzymes and proteins for instance, late embryogenesis abundant (lea), responsive to abscisic acid (Rab), rubisco, helicase, proline, glutathione-S-transferase (GST), and carbohydrates during drought stress. This review paper has concentrated on the study of water limitation and its effects on morphological, physiological, biochemical, and molecular responses of wheat with the possible losses caused by drought stress. PMID:24319376

  12. Salinity tolerance in halophytes.

    Science.gov (United States)

    Flowers, Timothy J; Colmer, Timothy D

    2008-01-01

    Halophytes, plants that survive to reproduce in environments where the salt concentration is around 200 mm NaCl or more, constitute about 1% of the world's flora. Some halophytes show optimal growth in saline conditions; others grow optimally in the absence of salt. However, the tolerance of all halophytes to salinity relies on controlled uptake and compartmentalization of Na+, K+ and Cl- and the synthesis of organic 'compatible' solutes, even where salt glands are operative. Although there is evidence that different species may utilize different transporters in their accumulation of Na+, in general little is known of the proteins and regulatory networks involved. Consequently, it is not yet possible to assign molecular mechanisms to apparent differences in rates of Na+ and Cl- uptake, in root-to-shoot transport (xylem loading and retrieval), or in net selectivity for K+ over Na+. At the cellular level, H+-ATPases in the plasma membrane and tonoplast, as well as the tonoplast H+-PPiase, provide the trans-membrane proton motive force used by various secondary transporters. The widespread occurrence, taxonomically, of halophytes and the general paucity of information on the molecular regulation of tolerance mechanisms persuade us that research should be concentrated on a number of 'model' species that are representative of the various mechanisms that might be involved in tolerance.

  13. Pareto versus lognormal: a maximum entropy test.

    Science.gov (United States)

    Bee, Marco; Riccaboni, Massimo; Schiavo, Stefano

    2011-08-01

    It is commonly found that distributions that seem to be lognormal over a broad range change to a power-law (Pareto) distribution for the last few percentiles. The distributions of many physical, natural, and social events (earthquake size, species abundance, income and wealth, as well as file, city, and firm sizes) display this structure. We present a test for the occurrence of power-law tails in statistical distributions based on maximum entropy. This methodology allows one to identify the true data-generating processes even in the case when it is neither lognormal nor Pareto. The maximum entropy approach is then compared with other widely used methods and applied to different levels of aggregation of complex systems. Our results provide support for the theory that distributions with lognormal body and Pareto tail can be generated as mixtures of lognormally distributed units.

  14. Maximum Variance Hashing via Column Generation

    Directory of Open Access Journals (Sweden)

    Lei Luo

    2013-01-01

    item search. Recently, a number of data-dependent methods have been developed, reflecting the great potential of learning for hashing. Inspired by the classic nonlinear dimensionality reduction algorithm—maximum variance unfolding, we propose a novel unsupervised hashing method, named maximum variance hashing, in this work. The idea is to maximize the total variance of the hash codes while preserving the local structure of the training data. To solve the derived optimization problem, we propose a column generation algorithm, which directly learns the binary-valued hash functions. We then extend it using anchor graphs to reduce the computational cost. Experiments on large-scale image datasets demonstrate that the proposed method outperforms state-of-the-art hashing methods in many cases.

  15. Solar Maximum Mission - A systems overview

    Science.gov (United States)

    Guha, A. K.

    1981-01-01

    The Solar Maximum Mission (SMM), or the central effort of the Solar Maximum Year research endeavor is discussed. The mission's attempt to exploit the synergistic advantages of correlated data to obtain a complete picture of solar phenomena is stressed, as is the coordination provided by a world-wide network of ground-based observations. The prominent features of the SMM observatory, including the payload module and the solar-array system, are shown diagramatically and the science instruments (coronagraph/polarimeter, ultraviolet spectrometer/polarimeter, soft X-ray polychromater) are discussed. Descriptions of the spacecraft's electrical power system, attitude determination and control systems and communications systems are also included. The Experiment Operations Facility, which provides quick response to rapidly changing solar conditions and permits coordination with a multitude of ground observatories and coordinated experiments, is described.

  16. Model fit after pairwise maximum likelihood

    Directory of Open Access Journals (Sweden)

    M. T. eBarendse

    2016-04-01

    Full Text Available Maximum likelihood factor analysis of discrete data within the structural equation modeling framework rests on the assumption that the observed discrete responses are manifestations of underlying continuous scores that are normally distributed. As maximizing the likelihood of multivariate response patterns is computationally very intensive, the sum of the log--likelihoods of the bivariate response patterns is maximized instead. Little is yet known about how to assess model fit when the analysis is based on such a pairwise maximum likelihood (PML of two--way contingency tables. We propose new fit criteria for the PML method and conduct a simulation study to evaluate their performance in model selection. With large sample sizes (500 or more, PML performs as well the robust weighted least squares analysis of polychoric correlations.

  17. A Maximum Radius for Habitable Planets.

    Science.gov (United States)

    Alibert, Yann

    2015-09-01

    We compute the maximum radius a planet can have in order to fulfill two constraints that are likely necessary conditions for habitability: 1- surface temperature and pressure compatible with the existence of liquid water, and 2- no ice layer at the bottom of a putative global ocean, that would prevent the operation of the geologic carbon cycle to operate. We demonstrate that, above a given radius, these two constraints cannot be met: in the Super-Earth mass range (1-12 Mearth), the overall maximum that a planet can have varies between 1.8 and 2.3 Rearth. This radius is reduced when considering planets with higher Fe/Si ratios, and taking into account irradiation effects on the structure of the gas envelope.

  18. Zipf's law, power laws and maximum entropy

    Science.gov (United States)

    Visser, Matt

    2013-04-01

    Zipf's law, and power laws in general, have attracted and continue to attract considerable attention in a wide variety of disciplines—from astronomy to demographics to software structure to economics to linguistics to zoology, and even warfare. A recent model of random group formation (RGF) attempts a general explanation of such phenomena based on Jaynes' notion of maximum entropy applied to a particular choice of cost function. In the present paper I argue that the specific cost function used in the RGF model is in fact unnecessarily complicated, and that power laws can be obtained in a much simpler way by applying maximum entropy ideas directly to the Shannon entropy subject only to a single constraint: that the average of the logarithm of the observable quantity is specified.

  19. Maximum likelihood estimation of fractionally cointegrated systems

    DEFF Research Database (Denmark)

    Lasak, Katarzyna

    In this paper we consider a fractionally cointegrated error correction model and investigate asymptotic properties of the maximum likelihood (ML) estimators of the matrix of the cointe- gration relations, the degree of fractional cointegration, the matrix of the speed of adjustment to the equilib......In this paper we consider a fractionally cointegrated error correction model and investigate asymptotic properties of the maximum likelihood (ML) estimators of the matrix of the cointe- gration relations, the degree of fractional cointegration, the matrix of the speed of adjustment...... to the equilibrium parameters and the variance-covariance matrix of the error term. We show that using ML principles to estimate jointly all parameters of the fractionally cointegrated system we obtain consistent estimates and provide their asymptotic distributions. The cointegration matrix is asymptotically mixed...

  20. A Multirelational Account of Toleration

    DEFF Research Database (Denmark)

    Ferretti, Maria Paola; Lægaard, Sune

    2013-01-01

    be understood purely attitudinally or purely politically, we argue that the components of classical toleration are crucial elements of contemporary cases of minority accommodation. The concept of toleration is applicable to, and is an important element of descriptions of such cases, provided that one views them...... and Denmark. Finally, we propose that intersectionality is not only relevant to the descriptive concept of toleration but also captures an important aspect of normative theories of toleration. We illustrate this by discussing ideals of respect-based toleration, which we also apply to the case studies....

  1. Plant Distribution Data Show Broader Climatic Limits than Expert-Based Climatic Tolerance Estimates.

    Directory of Open Access Journals (Sweden)

    Caroline A Curtis

    Full Text Available Although increasingly sophisticated environmental measures are being applied to species distributions models, the focus remains on using climatic data to provide estimates of habitat suitability. Climatic tolerance estimates based on expert knowledge are available for a wide range of plants via the USDA PLANTS database. We aim to test how climatic tolerance inferred from plant distribution records relates to tolerance estimated by experts. Further, we use this information to identify circumstances when species distributions are more likely to approximate climatic tolerance.We compiled expert knowledge estimates of minimum and maximum precipitation and minimum temperature tolerance for over 1800 conservation plant species from the 'plant characteristics' information in the USDA PLANTS database. We derived climatic tolerance from distribution data downloaded from the Global Biodiversity and Information Facility (GBIF and corresponding climate from WorldClim. We compared expert-derived climatic tolerance to empirical estimates to find the difference between their inferred climate niches (ΔCN, and tested whether ΔCN was influenced by growth form or range size.Climate niches calculated from distribution data were significantly broader than expert-based tolerance estimates (Mann-Whitney p values << 0.001. The average plant could tolerate 24 mm lower minimum precipitation, 14 mm higher maximum precipitation, and 7° C lower minimum temperatures based on distribution data relative to expert-based tolerance estimates. Species with larger ranges had greater ΔCN for minimum precipitation and minimum temperature. For maximum precipitation and minimum temperature, forbs and grasses tended to have larger ΔCN while grasses and trees had larger ΔCN for minimum precipitation.Our results show that distribution data are consistently broader than USDA PLANTS experts' knowledge and likely provide more robust estimates of climatic tolerance, especially for

  2. Mammographic image restoration using maximum entropy deconvolution

    OpenAIRE

    Jannetta, Adrian; Jackson, John; Birch, Ian; Kotre, John; Robson, Kevin; Padgett, Rod

    2004-01-01

    An image restoration approach based on a Bayesian maximum entropy method (MEM) has been applied to a radiological image deconvolution problem, that of reduction of geometric blurring in magnification mammography. The aim of the work is to demonstrate an improvement in image spatial resolution in realistic noisy radiological images with no associated penalty in terms of reduction in the signal-to-noise ratio perceived by the observer. Images of the TORMAM mammographic image quality phantom wer...

  3. Maximum Entropy Moment Systems and Galilean Invariance

    OpenAIRE

    Junk, Michael; Unterreiter, Andreas

    2001-01-01

    In this article, we investigate the maximum entropy moment closure in gas dynamics. We show that the usual choice of polynomial weight functions may lead to hyperbolic systems with an unpleasant state space: equilibrium states are boundary points with possibly singular fluxes. In order to avoid singularities, the necessary arises to find weight functions which growing sub-quadratically at infinity. Unfortunately, this requirement leads to a conflict with Galilean invariance of the moment syst...

  4. Shape Modelling Using Maximum Autocorrelation Factors

    DEFF Research Database (Denmark)

    Larsen, Rasmus

    2001-01-01

    of Active Shape Models by Timothy Cootes and Christopher Taylor by building new information into the model. This new information consists of two types of prior knowledge. First, in many situation we will be given an ordering of the shapes of the training set. This situation occurs when the shapes....... Both these types of knowledge may be used to defined Shape Maximum Autocorrelation Factors. The resulting point distribution models are compared to ordinary principal components analysis using leave-one-out validation....

  5. [Maximum entropy principle and population genetic equilibrium].

    Science.gov (United States)

    Wang, Xiao-Long; Yuan, Zhi-Fa; Guo, Man-Cai; Song, Shi-De; Zhang, Quan-Qi; Bao, Zhen-Min

    2002-06-01

    A general mathematic model of population genetic equilibrium was constructed based on the maximum entropy principle. We proved that the maximum entropy probability distribution was equivalent to the Hardy-Weinberg equilibrium law. A population reached genetic equilibrium when the genotype entropy of the population reached the maximal possible value. In information theory, the entropy or the information content is used to measure the uncertainty of a system. In population genetics, we can use entropy to measure the uncertainty of the genotype of a population. The agreement of the maximum entropy principle and the hardy-Weinberg equilibrium law indicated that random crossing is an irreversible process, which increases the genotype entropy of the population, while inbreeding and selection decrease the genotype entropy of the population. In animal or plant breeding, we often use selection and/or inbreeding to decrease the entropy of a population, and use intercrossing to increase the entropy of the population. In this point of view, breeding is actually regulating the entropy of population. By applying the basic principle of informatics in population genetics, we revealed the biological significance of the genotype entropy and demonstrated that we can work over population genetic problems with the principles and methods of informatics and cybernetics.

  6. A Maximum Resonant Set of Polyomino Graphs

    Directory of Open Access Journals (Sweden)

    Zhang Heping

    2016-05-01

    Full Text Available A polyomino graph P is a connected finite subgraph of the infinite plane grid such that each finite face is surrounded by a regular square of side length one and each edge belongs to at least one square. A dimer covering of P corresponds to a perfect matching. Different dimer coverings can interact via an alternating cycle (or square with respect to them. A set of disjoint squares of P is a resonant set if P has a perfect matching M so that each one of those squares is M-alternating. In this paper, we show that if K is a maximum resonant set of P, then P − K has a unique perfect matching. We further prove that the maximum forcing number of a polyomino graph is equal to the cardinality of a maximum resonant set. This confirms a conjecture of Xu et al. [26]. We also show that if K is a maximal alternating set of P, then P − K has a unique perfect matching.

  7. Continuity of the Maximum-Entropy Inference

    Science.gov (United States)

    Stephan, Weis

    2014-09-01

    We study the inverse problem of inferring the state of a finite-level quantum system from expected values of a fixed set of observables, by maximizing a continuous ranking function. We have proved earlier that the maximum-entropy inference can be a discontinuous map from the convex set of expected values to the convex set of states because the image contains states of reduced support, while this map restricts to a smooth parametrization of a Gibbsian family of fully supported states. Here we prove for arbitrary ranking functions that the inference is continuous up to boundary points. This follows from a continuity condition in terms of the openness of the restricted linear map from states to their expected values. The openness condition shows also that ranking functions with a discontinuous inference are typical. Moreover it shows that the inference is continuous in the restriction to any polytope which implies that a discontinuity belongs to the quantum domain of non-commutative observables and that a geodesic closure of a Gibbsian family equals the set of maximum-entropy states. We discuss eight descriptions of the set of maximum-entropy states with proofs of accuracy and an analysis of deviations.

  8. The maximum rate of mammal evolution

    Science.gov (United States)

    Evans, Alistair R.; Jones, David; Boyer, Alison G.; Brown, James H.; Costa, Daniel P.; Ernest, S. K. Morgan; Fitzgerald, Erich M. G.; Fortelius, Mikael; Gittleman, John L.; Hamilton, Marcus J.; Harding, Larisa E.; Lintulaakso, Kari; Lyons, S. Kathleen; Okie, Jordan G.; Saarinen, Juha J.; Sibly, Richard M.; Smith, Felisa A.; Stephens, Patrick R.; Theodor, Jessica M.; Uhen, Mark D.

    2012-03-01

    How fast can a mammal evolve from the size of a mouse to the size of an elephant? Achieving such a large transformation calls for major biological reorganization. Thus, the speed at which this occurs has important implications for extensive faunal changes, including adaptive radiations and recovery from mass extinctions. To quantify the pace of large-scale evolution we developed a metric, clade maximum rate, which represents the maximum evolutionary rate of a trait within a clade. We applied this metric to body mass evolution in mammals over the last 70 million years, during which multiple large evolutionary transitions occurred in oceans and on continents and islands. Our computations suggest that it took a minimum of 1.6, 5.1, and 10 million generations for terrestrial mammal mass to increase 100-, and 1,000-, and 5,000-fold, respectively. Values for whales were down to half the length (i.e., 1.1, 3, and 5 million generations), perhaps due to the reduced mechanical constraints of living in an aquatic environment. When differences in generation time are considered, we find an exponential increase in maximum mammal body mass during the 35 million years following the Cretaceous-Paleogene (K-Pg) extinction event. Our results also indicate a basic asymmetry in macroevolution: very large decreases (such as extreme insular dwarfism) can happen at more than 10 times the rate of increases. Our findings allow more rigorous comparisons of microevolutionary and macroevolutionary patterns and processes.

  9. Quantum money with nearly optimal error tolerance

    Science.gov (United States)

    Amiri, Ryan; Arrazola, Juan Miguel

    2017-06-01

    We present a family of quantum money schemes with classical verification which display a number of benefits over previous proposals. Our schemes are based on hidden matching quantum retrieval games and they tolerate noise up to 23 % , which we conjecture reaches 25 % asymptotically as the dimension of the underlying hidden matching states is increased. Furthermore, we prove that 25 % is the maximum tolerable noise for a wide class of quantum money schemes with classical verification, meaning our schemes are almost optimally noise tolerant. We use methods in semidefinite programming to prove security in a substantially different manner to previous proposals, leading to two main advantages: first, coin verification involves only a constant number of states (with respect to coin size), thereby allowing for smaller coins; second, the reusability of coins within our scheme grows linearly with the size of the coin, which is known to be optimal. Last, we suggest methods by which the coins in our protocol could be implemented using weak coherent states and verified using existing experimental techniques, even in the presence of detector inefficiencies.

  10. Some physiological aspects of artificial gravity. [gravitational effects on human orthostatic tolerance and physical fitness

    Science.gov (United States)

    Cramer, D. B.; Graybiel, A.

    1973-01-01

    The effects of increasing artificial gravity exposure on four aspects of physiological fitness are examined in four young men who, prior to exposure, were deconditioned with bed rest and water immersion. The four aspects of physiological fitness are orthostatic tolerance, exercise tolerance, forearm endurance, and maximum strength. Orthostatic tolerance was sharply reduced by deconditioning and was substantially improved by walking in simulated lunar gravity (1/6 g) for 2.5 hours daily for 7 days or by walking in 1/2 g and 1 g for 1 hour daily for 3 days. Exercise tolerance was also sharply reduced by deconditioning but did not significantly improve with increasing g-exposure. Walking in 1 g for 1 hour daily for 3 days raised exercise tolerance only a little above the low produced by deconditioning. Forearm endurance and maximum strength were relatively unaffected by deconditioning and subsequent g-exposure.

  11. Noise tolerant dendritic lattice associative memories

    Science.gov (United States)

    Ritter, Gerhard X.; Schmalz, Mark S.; Hayden, Eric; Tucker, Marc

    2011-09-01

    Linear classifiers based on computation over the real numbers R (e.g., with operations of addition and multiplication) denoted by (R, +, x), have been represented extensively in the literature of pattern recognition. However, a different approach to pattern classification involves the use of addition, maximum, and minimum operations over the reals in the algebra (R, +, maximum, minimum) These pattern classifiers, based on lattice algebra, have been shown to exhibit superior information storage capacity, fast training and short convergence times, high pattern classification accuracy, and low computational cost. Such attributes are not always found, for example, in classical neural nets based on the linear inner product. In a special type of lattice associative memory (LAM), called a dendritic LAM or DLAM, it is possible to achieve noise-tolerant pattern classification by varying the design of noise or error acceptance bounds. This paper presents theory and algorithmic approaches for the computation of noise-tolerant lattice associative memories (LAMs) under a variety of input constraints. Of particular interest are the classification of nonergodic data in noise regimes with time-varying statistics. DLAMs, which are a specialization of LAMs derived from concepts of biological neural networks, have successfully been applied to pattern classification from hyperspectral remote sensing data, as well as spatial object recognition from digital imagery. The authors' recent research in the development of DLAMs is overviewed, with experimental results that show utility for a wide variety of pattern classification applications. Performance results are presented in terms of measured computational cost, noise tolerance, classification accuracy, and throughput for a variety of input data and noise levels.

  12. Exercise-induced hypoalgesia: Pain tolerance, preference and tolerance for exercise intensity, and physiological correlates following dynamic circuit resistance exercise.

    Science.gov (United States)

    Baiamonte, Brandon A; Kraemer, Robert R; Chabreck, Chelsea N; Reynolds, Matthew L; McCaleb, Kayla M; Shaheen, Georgia L; Hollander, Daniel B

    2017-09-01

    Previous research has demonstrated significant decreases in pain perception in healthy individuals following both aerobic and upper body resistance exercise, but research on circuit training has been limited. The purpose of the study was to determine the effects of a strenuous bout of dynamic circuit resistance exercise on pain threshold and pain tolerance in conjunction with changes in blood lactate levels, heart rate (HR), and perceived exertion. A sample of 24 college-age students participated in 2 sessions: (1) a maximal strength testing session and (2) a circuit training bout of exercise that consisted of 3 sets of 12 repetitions with a 1:1 work to rest ratio at 60% one-repetition maximum (1-RM) predicted from a three-repetition maximum (3-RM) for 9 exercises. Participants exhibited increases in pain tolerance, blood lactate levels, HR and perceived exertion following resistance exercise. Preference for exercise intensity was positively correlated with lactate post exercise and tolerance for exercise intensity was positively correlated with pain tolerance and lactate post exercise. In conclusion, this is the first study to demonstrate increases in pain tolerance following a dynamic circuit resistance exercise protocol and disposition for exercise intensity may influence lactate and pain responses to circuit resistance exercise.

  13. Allergen Immunotherapy and Tolerance

    Directory of Open Access Journals (Sweden)

    Tomokazu Matsuoka

    2013-01-01

    Full Text Available Successful allergen-specific immunotherapy (AIT is associated with a marked decrease in symptoms on allergen exposure, a reduced requirement for 'rescue' anti-allergic drugs and improvement in patients' quality of life. These benefits persist for at least several years following discontinuation of immunotherapy - the hallmark of clinical and immunological tolerance. AIT has been shown to modulate both innate and adaptive immunological responses. Early suppression of innate effector cells of allergic inflammation (mast cells, basophils, regulation of pro-allergic T helper 2 type (Th 2 responses and IgE+ B cell responses have been shown to occur both in the tissue and in the peripheral blood during AIT. The allergen-tolerant state is associated with local and systemic induction of distinct populations of allergen-specific T regulatory cells including IL-10+ Tregs (Tr1 cells, TGF-P+ Tregs and FoxP3+ memory T regs. B cells are switched in favour of producing IgG (particularly IgG4 antibodies and associated blocking activity for IgE-dependent events, including basophil activation and IgE-facilitated allergen binding to B cells. An induction of IL-10+ B regulatory cells and alterations in dendritic cell subsets have also recently been described. These events are followed by the induction of T regulatory cells, suppression of allergen-specific T cell proliferation and immune deviation from Th2 in favour of Th1 responses. Alternative mechanisms of tolerance include apoptosis/deletion of antigen-specific memory Th2 cells and/or a failure of co-stimulation leading to T cell anergy.

  14. Inherent Problems in Designing Two-Failure Tolerant Electromechanical Actuators

    Science.gov (United States)

    Hornyak, S.

    1984-01-01

    An electromechanical ac-powered rotary actuated four-bar linkage system for rotating the Shuttle/Centaur deployment adapter is described. The essential features of the deployment adapter rotation system (DARS) are increased reliability for mission success and maximum practical hazard control for safety. The requirements, concept development, hardware configuration, quality assurance provisions, and techniques used to meet two-fault tolerance requirements are highlighted. The rationale used to achieve a degree of safety equivalent of that of two-failure tolerance is presented. Conditions that make this approach acceptable, including single failure point components with regard to redundancy versus credibility of failure modes, are also discussed.

  15. Toleration, Synthesis or Replacement?

    DEFF Research Database (Denmark)

    Holtermann, Jakob v. H.; Madsen, Mikael Rask

    2016-01-01

    , in order to answer is not yet another partisan suggestion, but rather an attempt at making intelligible both the oppositions and the possibilities of synthesis between normative and empirical approaches to law. Based on our assessment and rational reconstruction of current arguments and positions, we...... therefore outline a taxonomy consisting of the following three basic, ideal-types in terms of the epistemological understanding of the interface of law and empirical studies: toleration, synthesis and replacement. This tripartite model proves useful with a view to teasing out and better articulating...

  16. Fault Tolerant Distributive Processing

    Science.gov (United States)

    Quesnell, Harris

    1982-12-01

    A fault tolerant design used to enhanced the survivability of a distributive processing system is described. Based on physical limitations, mission duration and maintenance support, the approach has emphasized functional redundancy in place of the traditional hardware or software level redundancy. A top down architecture within the system's hierarchy allows sharing of common resources. Various techniques used to enhance the survivability of the hardware at the equipment, module and component level were analyzed. The intent of the on going work is to demonstrate the ability of a distributive processing system to maintain itself for a long period of time.

  17. Fault Tolerant Computer Architecture

    CERN Document Server

    Sorin, Daniel

    2009-01-01

    For many years, most computer architects have pursued one primary goal: performance. Architects have translated the ever-increasing abundance of ever-faster transistors provided by Moore's law into remarkable increases in performance. Recently, however, the bounty provided by Moore's law has been accompanied by several challenges that have arisen as devices have become smaller, including a decrease in dependability due to physical faults. In this book, we focus on the dependability challenge and the fault tolerance solutions that architects are developing to overcome it. The two main purposes

  18. Maximum caliber inference of nonequilibrium processes

    Science.gov (United States)

    Otten, Moritz; Stock, Gerhard

    2010-07-01

    Thirty years ago, Jaynes suggested a general theoretical approach to nonequilibrium statistical mechanics, called maximum caliber (MaxCal) [Annu. Rev. Phys. Chem. 31, 579 (1980)]. MaxCal is a variational principle for dynamics in the same spirit that maximum entropy is a variational principle for equilibrium statistical mechanics. Motivated by the success of maximum entropy inference methods for equilibrium problems, in this work the MaxCal formulation is applied to the inference of nonequilibrium processes. That is, given some time-dependent observables of a dynamical process, one constructs a model that reproduces these input data and moreover, predicts the underlying dynamics of the system. For example, the observables could be some time-resolved measurements of the folding of a protein, which are described by a few-state model of the free energy landscape of the system. MaxCal then calculates the probabilities of an ensemble of trajectories such that on average the data are reproduced. From this probability distribution, any dynamical quantity of the system can be calculated, including population probabilities, fluxes, or waiting time distributions. After briefly reviewing the formalism, the practical numerical implementation of MaxCal in the case of an inference problem is discussed. Adopting various few-state models of increasing complexity, it is demonstrated that the MaxCal principle indeed works as a practical method of inference: The scheme is fairly robust and yields correct results as long as the input data are sufficient. As the method is unbiased and general, it can deal with any kind of time dependency such as oscillatory transients and multitime decays.

  19. Maximum entropy and Bayesian methods. Proceedings.

    Science.gov (United States)

    Fougère, P. F.

    Bayesian probability theory and maximum entropy are the twin foundations of consistent inductive reasoning about the physical world. This volume contains thirty-two papers which are devoted to both foundations and applications and combine tutorial presentations and more research oriented contributions. Together these provide a state of the art account of latest developments in such diverse areas as coherent imaging, regression analysis, tomography, neural networks, plasma theory, quantum mechanics, and others. The methods described will be of great interest to mathematicians, physicists, astronomers, crystallographers, engineers and those involved in all aspects of signal processing.

  20. Conductivity maximum in a charged colloidal suspension

    Energy Technology Data Exchange (ETDEWEB)

    Bastea, S

    2009-01-27

    Molecular dynamics simulations of a charged colloidal suspension in the salt-free regime show that the system exhibits an electrical conductivity maximum as a function of colloid charge. We attribute this behavior to two main competing effects: colloid effective charge saturation due to counterion 'condensation' and diffusion slowdown due to the relaxation effect. In agreement with previous observations, we also find that the effective transported charge is larger than the one determined by the Stern layer and suggest that it corresponds to the boundary fluid layer at the surface of the colloidal particles.

  1. Maximum Probability Domains for Hubbard Models

    CERN Document Server

    Acke, Guillaume; Claeys, Pieter W; Van Raemdonck, Mario; Poelmans, Ward; Van Neck, Dimitri; Bultinck, Patrick

    2015-01-01

    The theory of Maximum Probability Domains (MPDs) is formulated for the Hubbard model in terms of projection operators and generating functions for both exact eigenstates as well as Slater determinants. A fast MPD analysis procedure is proposed, which is subsequently used to analyse numerical results for the Hubbard model. It is shown that the essential physics behind the considered Hubbard models can be exposed using MPDs. Furthermore, the MPDs appear to be in line with what is expected from Valence Bond Theory-based knowledge.

  2. Maximum power operation of interacting molecular motors

    DEFF Research Database (Denmark)

    Golubeva, Natalia; Imparato, Alberto

    2013-01-01

    , as compared to the non-interacting system, in a wide range of biologically compatible scenarios. We furthermore consider the case where the motor-motor interaction directly affects the internal chemical cycle and investigate the effect on the system dynamics and thermodynamics.......We study the mechanical and thermodynamic properties of different traffic models for kinesin which are relevant in biological and experimental contexts. We find that motor-motor interactions play a fundamental role by enhancing the thermodynamic efficiency at maximum power of the motors...

  3. On the maximum drawdown during speculative bubbles

    Science.gov (United States)

    Rotundo, Giulia; Navarra, Mauro

    2007-08-01

    A taxonomy of large financial crashes proposed in the literature locates the burst of speculative bubbles due to endogenous causes in the framework of extreme stock market crashes, defined as falls of market prices that are outlier with respect to the bulk of drawdown price movement distribution. This paper goes on deeper in the analysis providing a further characterization of the rising part of such selected bubbles through the examination of drawdown and maximum drawdown movement of indices prices. The analysis of drawdown duration is also performed and it is the core of the risk measure estimated here.

  4. The Effect Of A Provisional Sequestration Order - Does It Impose A Limitation To My Right To Be A Member Of Parliament?

    Directory of Open Access Journals (Sweden)

    Leonie Stander

    2015-12-01

    Full Text Available The question asked in this article is inspired by the recent case of Mr Julius Malema. Why the matter is so important and has enjoyed so much attention, is the fact that it was widely suggested that a final order of sequestration would affect Mr Malema's political career in that it would not be possible for him to continue to serve as Member of Parliament. The question that immediately comes to the fore is whether the provisional order of sequestration would not already result in such an outcome. As stipulated by the Constitution of the Republic of South Africa, 1996, an unrehabilitated insolvent may not become a member of the National Assembly, National Council of Provinces, or a Provincial Legislator. Do the words "unrehabilitated insolvent" also include a person who is under provisional sequestration? The purpose of this article is to investigate the effect of a provisional order of sequestration and the focus will be on the ability of an insolvent to act as a Member of Parliament. The legal position in the South African law will be compared with the legal position in the United States of America – which is, with regard to the insolvency law, recognized as a very successful, modern, progressive and dynamic legal system. Voluminous changes to the American bankruptcy law system, to adapt to current practical situations and the current economic climate, have been effected as recently as in 2005. Brief reference will also be made to the legal position in the United Kingdom, due to South Africa's historical ties with the UK and the reliance in the past on the English insolvency law and the Bankruptcy Act, 1986.

  5. Evaluation of Bond Strength between Grooved Titanium Alloy Implant Abutments and Provisional Veneering Materials after Surface Treatment of the Abutments: AnIn vitroStudy.

    Science.gov (United States)

    Venkat, Gowtham; Krishnan, Murugesan; Srinivasan, Suganya; Balasubramanian, Muthukumar

    2017-01-01

    Titanium has become the material of choice with greater applications in dental implants. The success of the dental implant does not only depend on the integration of the implant to the bone but also on the function and longevity of the superstructure. The clinical condition that demands long-term interim prosthesis is challenging owing to the decreased bond between the abutment and the veneering material. Hence, various surface treatments are done on the abutments to increase the bond strength. This study aimed to evaluate the bond strength between the abutment and the provisional veneering materials by surface treatments such as acid etching, laser etching, and sand blasting of the abutment. Forty titanium alloy abutments of 3 mm diameter and 11 mm height were grouped into four groups with ten samples. Groups A, B, C, and D are untreated abutments, sand blasted with 110 μm aluminum particles, etched with 1% hydrofluoric acid and 30% nitric acid, and laser etched with Nd: YAG laser, respectively. Provisional crowns were fabricated with bis-acrylic resin and cemented with noneugenol temporary luting cement. The shear bond strength was measured in universal testing machine using modified Shell-Nielsen shear test after the cemented samples were stored in water at 25°C for 24 h. Load was applied at a constant cross head speed of 5 mm/min until a sudden decrease in resistance indicative of bond failure was observed. The corresponding force values were recorded, and statistical analysis was done using one-way ANOVA and Newman-Keuls post hoc test. The laser-etched samples showed higher bond strength. Among the three surface treatments, laser etching showed the highest bond strength between titanium alloy implant abutment and provisional restorations. The sand-blasted surfaces demonstrated a significant difference in bond strength compared to laser-etched surfaces. The results of this study confirmed that a combination of surface treatments and bond agents enhances the

  6. Provisional T-drug-eluting stenting technique for the treatment of bifurcation lesions: clinical, myocardial scintigraphy and (late) coronary angiographic results.

    Science.gov (United States)

    Vigna, Carlo; Biondi-Zoccai, Giuseppe; Amico, Cesare M; Lanna, Pompeo; Stanislao, Mario; Santoro, Tiberio; Valle, Guido; Fanelli, Raffaele; Loperfido, Francesco

    2007-03-01

    Treatment of bifurcation stenoses (BS) by percutaneous coronary intervention (PCI) remains challenging, even with drug-eluting stents (DES). We aimed to appraise clinical, myocardial scintigraphy and late (>9 months) exploratory angiographic outcomes of provisional T-stenting in the management of BS. We enrolled 53 consecutive patients with BS in the proximity of a greater than or equal to 2 mm side branch (SB). The provisional T-technique was performed in all cases, with implantation of DES in the main branch (MB), SB balloon-only dilatation, and final kissing in the event of >50% SB stenosis. Provisional SB-stenting (using another DES) was reserved to cases with persisting >50% stenosis/dissection and reduced TIMI flow. Further kissing inflation was recommended in such patients. Stress/rest single-photon emission computed tomography (MIBI) and coronary angiography follow up were scheduled >6 and 9 months after PCI, respectively. Major adverse cardiac events at 14 +/- 3 months occurred in 5 patients (9.4% [95% confidence interval 0.1-17.4%]: 1 (1.9% [0.1-5.8%]) non-Q-wave myocardial infarction for subacute stent thrombosis, 2 (3.8% [0.1-9.0%]) target lesion revascularizations and 2 (3.8% [0.1-9.0%]) target vessel revascularizations. Six-month MIBI was performed in 51 patients (96.3%): 4 patients had positive results (7.8% [0.2-15.4%]). Angiography was performed in 4 of these patients and in another 27 patients, with clinical restenosis occurring overall in only 5 (16.1% [8.9-23.3%]), 1 case of clinical restenosis in the MB (3.2% [0.6-9.4%]), and 4 in the SB (12.9% [5.1-24.9%]). This study suggests the safety and efficacy of provisional T-drug-eluting stent implantation in bifurcation coronary lesions, and supports the use of follow-up myocardial scintigraphy, with angiography reserved for selected patients and lesions.

  7. The effects of an airborne-particle abrasion and silica-coating on the bond strength between grooved titanium alloy temporary cylinders and provisional veneering materials.

    Science.gov (United States)

    Wei, Ann Yu-Chieh; Sharma, Arun B; Watanabe, Larry G; Finzen, Frederick C

    2011-03-01

    Even though mechanical retentive features, such as grooves, are incorporated into the surface of titanium alloy temporary cylinders, a reliable bond to veneering provisional materials is not always achievable for screw-retained provisional implant restorations. There is insufficient information about the effect of tribochemical silica coating on the bond strength between provisional materials and grooved titanium alloy temporary cylinders. The purpose of this study was to evaluate, in vitro, the effect of an airborne-particle abrasion and silica-coating technique on the bond strength between grooved titanium alloy temporary cylinders and provisional veneering bisphenol-A glycidyl methacrylate and polymethyl methacrylate materials. Forty grooved titanium alloy (Ti-6Al-4V) internal connection implant temporary cylinders were used. A disc of veneering material (7.1 × 3.4 mm) was created around the midsection of each cylinder. Forty specimens were divided into 4 groups (n=10): group NoTxPMMA, no surface treatment and polymethyl methacrylate veneering material; group NoTxBisGMA, no surface treatment and BisGMA veneering material; group AbPMMA, airborne-particle abrasion, silica-coating surface treatment (Rocatec), and polymethyl methacrylate; and group AbBisGMA, airborne-particle abrasion, silica-coating surface treatment (Rocatec), and BisGMA. Each specimen was subjected to ultimate shear load testing at the interface of the veneering material and the temporary cylinder in a universal testing machine at a constant crosshead speed of 5 mm/min. Data were analyzed with a 1-way ANOVA (α=.05) followed by post hoc Student-Newman-Keuls test. Each specimen underwent surface observation with a light microscope at ×40 magnification to compare fracture patterns. Airborne-particle abrasion and silica-coating surface treatment significantly lowered the shear bond strength (Pveneering materials. It weakened the provided mechanical retention, especially when it was used with Bis

  8. The Maximum Resource Bin Packing Problem

    DEFF Research Database (Denmark)

    Boyar, J.; Epstein, L.; Favrholdt, L.M.

    2006-01-01

    Usually, for bin packing problems, we try to minimize the number of bins used or in the case of the dual bin packing problem, maximize the number or total size of accepted items. This paper presents results for the opposite problems, where we would like to maximize the number of bins used...... or minimize the number or total size of accepted items. We consider off-line and on-line variants of the problems. For the off-line variant, we require that there be an ordering of the bins, so that no item in a later bin fits in an earlier bin. We find the approximation ratios of two natural approximation...... algorithms, First-Fit-Increasing and First-Fit-Decreasing for the maximum resource variant of classical bin packing. For the on-line variant, we define maximum resource variants of classical and dual bin packing. For dual bin packing, no on-line algorithm is competitive. For classical bin packing, we find...

  9. Maximum Likelihood Analysis in the PEN Experiment

    Science.gov (United States)

    Lehman, Martin

    2013-10-01

    The experimental determination of the π+ -->e+ ν (γ) decay branching ratio currently provides the most accurate test of lepton universality. The PEN experiment at PSI, Switzerland, aims to improve the present world average experimental precision of 3 . 3 ×10-3 to 5 ×10-4 using a stopped beam approach. During runs in 2008-10, PEN has acquired over 2 ×107 πe 2 events. The experiment includes active beam detectors (degrader, mini TPC, target), central MWPC tracking with plastic scintillator hodoscopes, and a spherical pure CsI electromagnetic shower calorimeter. The final branching ratio will be calculated using a maximum likelihood analysis. This analysis assigns each event a probability for 5 processes (π+ -->e+ ν , π+ -->μ+ ν , decay-in-flight, pile-up, and hadronic events) using Monte Carlo verified probability distribution functions of our observables (energies, times, etc). A progress report on the PEN maximum likelihood analysis will be presented. Work supported by NSF grant PHY-0970013.

  10. Efficient heuristics for maximum common substructure search.

    Science.gov (United States)

    Englert, Péter; Kovács, Péter

    2015-05-26

    Maximum common substructure search is a computationally hard optimization problem with diverse applications in the field of cheminformatics, including similarity search, lead optimization, molecule alignment, and clustering. Most of these applications have strict constraints on running time, so heuristic methods are often preferred. However, the development of an algorithm that is both fast enough and accurate enough for most practical purposes is still a challenge. Moreover, in some applications, the quality of a common substructure depends not only on its size but also on various topological features of the one-to-one atom correspondence it defines. Two state-of-the-art heuristic algorithms for finding maximum common substructures have been implemented at ChemAxon Ltd., and effective heuristics have been developed to improve both their efficiency and the relevance of the atom mappings they provide. The implementations have been thoroughly evaluated and compared with existing solutions (KCOMBU and Indigo). The heuristics have been found to greatly improve the performance and applicability of the algorithms. The purpose of this paper is to introduce the applied methods and present the experimental results.

  11. Thermodynamic hardness and the maximum hardness principle

    Science.gov (United States)

    Franco-Pérez, Marco; Gázquez, José L.; Ayers, Paul W.; Vela, Alberto

    2017-08-01

    An alternative definition of hardness (called the thermodynamic hardness) within the grand canonical ensemble formalism is proposed in terms of the partial derivative of the electronic chemical potential with respect to the thermodynamic chemical potential of the reservoir, keeping the temperature and the external potential constant. This temperature dependent definition may be interpreted as a measure of the propensity of a system to go through a charge transfer process when it interacts with other species, and thus it keeps the philosophy of the original definition. When the derivative is expressed in terms of the three-state ensemble model, in the regime of low temperatures and up to temperatures of chemical interest, one finds that for zero fractional charge, the thermodynamic hardness is proportional to T-1(I -A ) , where I is the first ionization potential, A is the electron affinity, and T is the temperature. However, the thermodynamic hardness is nearly zero when the fractional charge is different from zero. Thus, through the present definition, one avoids the presence of the Dirac delta function. We show that the chemical hardness defined in this way provides meaningful and discernible information about the hardness properties of a chemical species exhibiting integer or a fractional average number of electrons, and this analysis allowed us to establish a link between the maximum possible value of the hardness here defined, with the minimum softness principle, showing that both principles are related to minimum fractional charge and maximum stability conditions.

  12. Maximum height and minimum time vertical jumping.

    Science.gov (United States)

    Domire, Zachary J; Challis, John H

    2015-08-20

    The performance criterion in maximum vertical jumping has typically been assumed to simply raise the center of mass as high as possible. In many sporting activities minimizing movement time during the jump is likely also critical to successful performance. The purpose of this study was to examine maximum height jumps performed while minimizing jump time. A direct dynamics model was used to examine squat jump performance, with dual performance criteria: maximize jump height and minimize jump time. The muscle model had activation dynamics, force-length, force-velocity properties, and a series of elastic component representing the tendon. The simulations were run in two modes. In Mode 1 the model was placed in a fixed initial position. In Mode 2 the simulation model selected the initial squat configuration as well as the sequence of muscle activations. The inclusion of time as a factor in Mode 1 simulations resulted in a small decrease in jump height and moderate time savings. The improvement in time was mostly accomplished by taking off from a less extended position. In Mode 2 simulations, more substantial time savings could be achieved by beginning the jump in a more upright posture. However, when time was weighted more heavily in these simulations, there was a more substantial reduction in jump height. Future work is needed to examine the implications for countermovement jumping and to examine the possibility of minimizing movement time as part of the control scheme even when the task is to jump maximally. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Maximum preheating in the liquid phase

    Energy Technology Data Exchange (ETDEWEB)

    1944-03-31

    This report dealt with the formation of hydrocarbons from CO or CO/sub 2/ to solve the problem of maximum preheating. Kroenig's old idea of operations with CO in the hydrogen was being tested to achieve increased temperatures in the converters. Dr. Kroenig tried to reduce the hydrogen consumption in the liquid phase when operating with oxygen-rich coals by the addition of a few percent CO to the fresh gas. This CO was supposed to compete with hydrogen for the oxygen of the coal, becoming converted to CO/sub 2/, which was stable at the relatively low temperatures of the converters. These experiments were discontinued. However, the idea of using the heat of reaction of the reaction of oxygen products with hydrogen to raise the temperature of the heater in the liquid phase was considered. It was known that the presence of even a few percent of CO in the fresh gas raised the converter temperature in the vapor phase dangerously, while the increase in the temperature of the preheater and the liquid phase converters amounted to but a few tenths of a millivolt. The reduction of CO with hydrogen was relatively slow but could be affected by catalysts. The heats of reactions for the various systems which could be utilized for heating were given. It was determined that from a standpoint of heat technology the formation of hydrocarbons from CO or CO/sub 2/ could be adapted to solve the problem of maximum preheating.

  14. Helminths and immunological tolerance.

    Science.gov (United States)

    Johnston, Chris J C; McSorley, Henry J; Anderton, Stephen M; Wigmore, Stephen J; Maizels, Rick M

    2014-01-27

    Current immunosuppression regimens for solid-organ transplantation have shown disappointing efficacy in the prevention of chronic allograft rejection and carry unacceptable risks including toxicity, neoplasia, and life-threatening infection. Achievement of immunological tolerance (long-term antigen unresponsiveness in an immunocompetent host) presents the exciting prospect of freedom from immunosuppression for transplant recipients. It is now 60 years since the first demonstration of immunological tolerance in animal models of transplantation, but translation into routine clinical practice remains elusive. Helminth parasites may provide novel strategies toward achieving this goal. Helminths are remarkably successful parasites: they currently infect more than one quarter of the world's population. It is now well established that the parasites' success is the result of active immunomodulation of their hosts' immune response. Although this primarily secures ongoing survival of the parasites, helminth-induced immunomodulation can also have a number of benefits for the host. Significant reductions in the prevalence of allergy and autoimmune conditions among helminth-infected populations are well recognized and there is now a significant body of evidence to suggest that harmful immune responses to alloantigens may be abrogated as well. Here, we review all existing studies of helminth infection and transplantation, explore the mechanisms involved, and discuss possible avenues for future translation to clinical practice.

  15. Ethnopoly promotes tolerance

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    On Friday 23 April, 225 primary school children from the eight schools in Meyrin-Cointrin and their accompanying adults took part in a big game of Ethnopoly. Private individuals, associations, administrations, shopkeepers and CERN all opened their doors to them to talk about their countries, their customs and what they are doing to promote tolerance and integration.   The CERN stand set up at ForumMeyrin for the Ethnopoly game. Scurrying from one place to another, the 10 and 11 year olds were made aware of the rich cultural diversity of their commune, which is home to 130 different nationalities. Physicists and engineers from CERN took up residence in the Forum Meyrin for the day in order to talk to the children about the advantages of international collaboration, a subject dear to the Organization's heart. They welcomed around fifty children in the course of the day, conveying to them a message of tolerance: despite their differences, the 10,000 scientists and other members of the CERN...

  16. Inflation Targeting: Provisional Results

    Directory of Open Access Journals (Sweden)

    Cerna, Silviu

    2010-06-01

    Full Text Available Inflation targeting monetary policy framework that requires the central bank to achieve a low inflation has contributed to price stability in industrialized countries. As well as the other developing countries, ex communist countries have also tried to apply this strategy, which was susceptible to increase monetary policy transparency and to determine authorities to make necessary reforms in order to pass from a planned to a market economy. In Romania, inflation targeting has contributed, to a large extent, to price increase smoothening, without affecting economic growth. Knowing the factors that have determined this unquestionable success allows for not only understanding the Romanian transition process, but also draw some useful conclusions in view of the necessary actions for adopting the euro.

  17. Lake Basin Fetch and Maximum Length/Width

    Data.gov (United States)

    Minnesota Department of Natural Resources — Linear features representing the Fetch, Maximum Length and Maximum Width of a lake basin. Fetch, maximum length and average width are calcuated from the lake polygon...

  18. Hydraulic Limits on Maximum Plant Transpiration

    Science.gov (United States)

    Manzoni, S.; Vico, G.; Katul, G. G.; Palmroth, S.; Jackson, R. B.; Porporato, A. M.

    2011-12-01

    Photosynthesis occurs at the expense of water losses through transpiration. As a consequence of this basic carbon-water interaction at the leaf level, plant growth and ecosystem carbon exchanges are tightly coupled to transpiration. In this contribution, the hydraulic constraints that limit transpiration rates under well-watered conditions are examined across plant functional types and climates. The potential water flow through plants is proportional to both xylem hydraulic conductivity (which depends on plant carbon economy) and the difference in water potential between the soil and the atmosphere (the driving force that pulls water from the soil). Differently from previous works, we study how this potential flux changes with the amplitude of the driving force (i.e., we focus on xylem properties and not on stomatal regulation). Xylem hydraulic conductivity decreases as the driving force increases due to cavitation of the tissues. As a result of this negative feedback, more negative leaf (and xylem) water potentials would provide a stronger driving force for water transport, while at the same time limiting xylem hydraulic conductivity due to cavitation. Here, the leaf water potential value that allows an optimum balance between driving force and xylem conductivity is quantified, thus defining the maximum transpiration rate that can be sustained by the soil-to-leaf hydraulic system. To apply the proposed framework at the global scale, a novel database of xylem conductivity and cavitation vulnerability across plant types and biomes is developed. Conductivity and water potential at 50% cavitation are shown to be complementary (in particular between angiosperms and conifers), suggesting a tradeoff between transport efficiency and hydraulic safety. Plants from warmer and drier biomes tend to achieve larger maximum transpiration than plants growing in environments with lower atmospheric water demand. The predicted maximum transpiration and the corresponding leaf water

  19. Commercialization of radiation tolerant camera

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Bum; Choi, Young Soo; Kim, Sun Ku; Lee, Jong Min; Cha, Bung Hun; Lee, Nam Ho; Byun, Eiy Gyo; Yoo, Seun Wook; Choi, Bum Ki; Yoon, Sung Up; Kim, Hyun Gun; Sin, Jeong Hun; So, Suk Il

    1999-12-01

    In this project, radiation tolerant camera which tolerates 10{sup 6} - 10{sup 8} rad total dose is developed. In order to develop radiation tolerant camera, radiation effect of camera components was examined and evaluated, and camera configuration was studied. By the result of evaluation, the components were decided and design was performed. Vidicon tube was selected to use by image sensor and non-browning optics and camera driving circuit were applied. The controller needed for CCTV camera system, lens, light, pan/tilt controller, was designed by the concept of remote control. And two type of radiation tolerant camera were fabricated consider to use in underwater environment or normal environment. (author)

  20. Physical fault tolerance of nanoelectronics.

    Science.gov (United States)

    Szkopek, Thomas; Roychowdhury, Vwani P; Antoniadis, Dimitri A; Damoulakis, John N

    2011-04-29

    The error rate in complementary transistor circuits is suppressed exponentially in electron number, arising from an intrinsic physical implementation of fault-tolerant error correction. Contrariwise, explicit assembly of gates into the most efficient known fault-tolerant architecture is characterized by a subexponential suppression of error rate with electron number, and incurs significant overhead in wiring and complexity. We conclude that it is more efficient to prevent logical errors with physical fault tolerance than to correct logical errors with fault-tolerant architecture.

  1. Maximum Profit Configurations of Commercial Engines

    Directory of Open Access Journals (Sweden)

    Yiran Chen

    2011-06-01

    Full Text Available An investigation of commercial engines with finite capacity low- and high-price economic subsystems and a generalized commodity transfer law [n ∝ Δ (P m] in commodity flow processes, in which effects of the price elasticities of supply and demand are introduced, is presented in this paper. Optimal cycle configurations of commercial engines for maximum profit are obtained by applying optimal control theory. In some special cases, the eventual state—market equilibrium—is solely determined by the initial conditions and the inherent characteristics of two subsystems; while the different ways of transfer affect the model in respects of the specific forms of the paths of prices and the instantaneous commodity flow, i.e., the optimal configuration.

  2. Co-Clustering under the Maximum Norm

    Directory of Open Access Journals (Sweden)

    Laurent Bulteau

    2016-02-01

    Full Text Available Co-clustering, that is partitioning a numerical matrix into “homogeneous” submatrices, has many applications ranging from bioinformatics to election analysis. Many interesting variants of co-clustering are NP-hard. We focus on the basic variant of co-clustering where the homogeneity of a submatrix is defined in terms of minimizing the maximum distance between two entries. In this context, we spot several NP-hard, as well as a number of relevant polynomial-time solvable special cases, thus charting the border of tractability for this challenging data clustering problem. For instance, we provide polynomial-time solvability when having to partition the rows and columns into two subsets each (meaning that one obtains four submatrices. When partitioning rows and columns into three subsets each, however, we encounter NP-hardness, even for input matrices containing only values from {0, 1, 2}.

  3. Maximum Spectral Luminous Efficacy of White Light

    CERN Document Server

    Murphy, T W

    2013-01-01

    As lighting efficiency improves, it is useful to understand the theoretical limits to luminous efficacy for light that we perceive as white. Independent of the efficiency with which photons are generated, there exists a spectrally-imposed limit to the luminous efficacy of any source of photons. We find that, depending on the acceptable bandpass and---to a lesser extent---the color temperature of the light, the ideal white light source achieves a spectral luminous efficacy of 250--370 lm/W. This is consistent with previous calculations, but here we explore the maximum luminous efficacy as a function of photopic sensitivity threshold, color temperature, and color rendering index; deriving peak performance as a function of all three parameters. We also present example experimental spectra from a variety of light sources, quantifying the intrinsic efficacy of their spectral distributions.

  4. Maximum spectral luminous efficacy of white light

    Science.gov (United States)

    Murphy, Thomas W.

    2012-05-01

    As lighting efficiency improves, it is useful to understand the theoretical limits to luminous efficacy for light that we perceive as white. Independent of the efficiency with which photons are generated, there exists a spectrally imposed limit to the luminous efficacy of any source of photons. We find that, depending on the acceptable bandpass and—to a lesser extent—the color temperature of the light, the ideal white light source achieves a spectral luminous efficacy of 250-370 lm/W. This is consistent with previous calculations, but here we explore the maximum luminous efficacy as a function of photopic sensitivity threshold, color temperature, and color rendering index; deriving peak performance as a function of all three parameters. We also present example experimental spectra from a variety of light sources, quantifying the intrinsic efficacy of their spectral distributions.

  5. Maximum screening fields of superconducting multilayer structures

    Science.gov (United States)

    Gurevich, Alex

    2015-01-01

    It is shown that a multilayer comprised of alternating thin superconducting and insulating layers on a thick substrate can fully screen the applied magnetic field exceeding the superheating fields Hs of both the superconducting layers and the substrate, the maximum Meissner field is achieved at an optimum multilayer thickness. For instance, a dirty layer of thickness ˜0.1 μm at the Nb surface could increase Hs ≃ 240 mT of a clean Nb up to Hs ≃ 290 mT. Optimized multilayers of Nb3Sn, NbN, some of the iron pnictides, or alloyed Nb deposited onto the surface of the Nb resonator cavities could potentially double the rf breakdown field, pushing the peak accelerating electric fields above 100 MV/m while protecting the cavity from dendritic thermomagnetic avalanches caused by local penetration of vortices.

  6. MLDS: Maximum Likelihood Difference Scaling in R

    Directory of Open Access Journals (Sweden)

    Kenneth Knoblauch

    2008-01-01

    Full Text Available The MLDS package in the R programming language can be used to estimate perceptual scales based on the results of psychophysical experiments using the method of difference scaling. In a difference scaling experiment, observers compare two supra-threshold differences (a,b and (c,d on each trial. The approach is based on a stochastic model of how the observer decides which perceptual difference (or interval (a,b or (c,d is greater, and the parameters of the model are estimated using a maximum likelihood criterion. We also propose a method to test the model by evaluating the self-consistency of the estimated scale. The package includes an example in which an observer judges the differences in correlation between scatterplots. The example may be readily adapted to estimate perceptual scales for arbitrary physical continua.

  7. Emitter frequency refinement based on maximum likelihood

    Science.gov (United States)

    Xu, Xin; Wang, Huijuan

    2015-07-01

    Frequency estimation via signal sorting is widely recognized as one of the most practical technologies in signal processing. However, the estimated frequencies via signal sorting may be inaccurate and biased due to signal fluctuation under different emitter working modes, problems of transmitter circuit, environmental noises or certain unknown interference sources. Therefore, it has become an important issue to further analyze and refine signal frequencies after signal sorting. To address the above problem, we have brought forward an iterative frequency refinement method based on maximum likelihood. Iteratively, the initial estimated signal frequency values are refined. Experimental results indicate that the refined signal frequencies are more informative than the initial ones. As another advantage of our method, noises and interference sources could be filtered out simultaneously. The efficiency and flexibility enables our method to apply in a wide application area, i.e., communication, electronic reconnaissance and radar intelligence analysis.

  8. The Federal Administrative Maximum Penitentiary, Florence, Colorado.

    Science.gov (United States)

    Coid, J W

    2001-10-01

    Policies for the control of dangerous and disruptive prisoners in European penal institutions depend upon social regimes managed by prison staff. These contrast with certain US regimes where there is increasing use of the incapacitation approach. This paper describes an incapacitation regime developed in the US Federal Administrative Maximum Penitentiary (ADX), Florence, Colorado which is complemented by an architectural design minimizing contact between prisoners and staff. This is reported to have been highly effective in controlling violent and predatory behaviour, escapes, drug-taking, and the influence of members of criminal gangs and notorious prisoners transferred to the ADX. Despite a shift of policy from therapeutic intervention towards deterrence of problem behaviour in prisons in some European countries, such as the UK, it is unlikely that such a regime would be acceptable in Europe.

  9. Spacecraft Maximum Allowable Concentrations for Airborne Contaminants

    Science.gov (United States)

    James, John T.

    2008-01-01

    The enclosed table lists official spacecraft maximum allowable concentrations (SMACs), which are guideline values set by the NASA/JSC Toxicology Group in cooperation with the National Research Council Committee on Toxicology (NRCCOT). These values should not be used for situations other than human space flight without careful consideration of the criteria used to set each value. The SMACs take into account a number of unique factors such as the effect of space-flight stress on human physiology, the uniform good health of the astronauts, and the absence of pregnant or very young individuals. Documentation of the values is given in a 5 volume series of books entitled "Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants" published by the National Academy Press, Washington, D.C. These books can be viewed electronically at http://books.nap.edu/openbook.php?record_id=9786&page=3. Short-term (1 and 24 hour) SMACs are set to manage accidental releases aboard a spacecraft and permit risk of minor, reversible effects such as mild mucosal irritation. In contrast, the long-term SMACs are set to fully protect healthy crewmembers from adverse effects resulting from continuous exposure to specific air pollutants for up to 1000 days. Crewmembers with allergies or unusual sensitivity to trace pollutants may not be afforded complete protection, even when long-term SMACs are not exceeded. Crewmember exposures involve a mixture of contaminants, each at a specific concentration (C(sub n)). These contaminants could interact to elicit symptoms of toxicity even though individual contaminants do not exceed their respective SMACs. The air quality is considered acceptable when the toxicity index (T(sub grp)) for each toxicological group of compounds is less than 1, where T(sub grp), is calculated as follows: T(sub grp) = C(sub 1)/SMAC(sub 1) + C(sub 2/SMAC(sub 2) + ...+C(sub n)/SMAC(sub n).

  10. NAFTA Guidance Document on Data Requirements for Tolerances on Imported Commodities in the United States and Canada

    Science.gov (United States)

    The purpose of this document is to provide detailed guidance on data requirements that meet the North American Free Trade Agreement standards for the establishment of pesticide import tolerances or maximum residue levels in Canada and the United States.

  11. Evaluation of pliers' grip spans in the maximum gripping task and sub-maximum cutting task.

    Science.gov (United States)

    Kim, Dae-Min; Kong, Yong-Ku

    2016-12-01

    A total of 25 males participated to investigate the effects of the grip spans of pliers on the total grip force, individual finger forces and muscle activities in the maximum gripping task and wire-cutting tasks. In the maximum gripping task, results showed that the 50-mm grip span had significantly higher total grip strength than the other grip spans. In the cutting task, the 50-mm grip span also showed significantly higher grip strength than the 65-mm and 80-mm grip spans, whereas the muscle activities showed a higher value at 80-mm grip span. The ratios of cutting force to maximum grip strength were also investigated. Ratios of 30.3%, 31.3% and 41.3% were obtained by grip spans of 50-mm, 65-mm, and 80-mm, respectively. Thus, the 50-mm grip span for pliers might be recommended to provide maximum exertion in gripping tasks, as well as lower maximum-cutting force ratios in the cutting tasks.

  12. Delay tolerant networks

    CERN Document Server

    Gao, Longxiang; Luan, Tom H

    2015-01-01

    This brief presents emerging and promising communication methods for network reliability via delay tolerant networks (DTNs). Different from traditional networks, DTNs possess unique features, such as long latency and unstable network topology. As a result, DTNs can be widely applied to critical applications, such as space communications, disaster rescue, and battlefield communications. The brief provides a complete investigation of DTNs and their current applications, from an overview to the latest development in the area. The core issue of data forward in DTNs is tackled, including the importance of social characteristics, which is an essential feature if the mobile devices are used for human communication. Security and privacy issues in DTNs are discussed, and future work is also discussed.

  13. Manufacturing tolerant topology optimization

    DEFF Research Database (Denmark)

    Sigmund, Ole

    2009-01-01

    In this paper we present an extension of the topology optimization method to include uncertainties during the fabrication of macro, micro and nano structures. More specifically, we consider devices that are manufactured using processes which may result in (uniformly) too thin (eroded) or too thick...... (dilated) structures compared to the intended topology. Examples are MEMS devices manufactured using etching processes, nano-devices manufactured using e-beam lithography or laser micro-machining and macro structures manufactured using milling processes. In the suggested robust topology optimization...... that the method provides manufacturing tolerant designs with little decrease in performance. As a positive side effect the robust design formulation also eliminates the longstanding problem of one-node connected hinges in compliant mechanism design using topology optimization....

  14. Development of a Provisional Model to Improve Transitional Care for Female Adolescents with a Rare Genital Malformation as an Example for Orphan Diseases

    Directory of Open Access Journals (Sweden)

    Elisabeth Simoes

    2014-01-01

    Full Text Available Deficits of care exist during the transitional period, when young people with ongoing needs of support to achieve their physical, social, and psychological potential are entering adulthood. This study aims to develop a patient oriented, structured provisional model to improve transitional care for adolescents with Mayer-Rokitansky-Kuester-Hauser-Syndrome as an example for orphan diseases, where problems of access and continuity are even more complex. The study is funded by the German Federal Ministry of Education and Research (BMBF-Funding Code 01GY1125. The target patient group are young females with this disorder, treated at the Centre for Rare Genital Malformations in Women (ZSGF, University Hospital of Tuebingen. The study comprises five phases: an appraisal of literature, assessment of patients (n=25, parents’, partners’, and health and social care providers’ (n=24 needs and experienced deficits in care and support in a qualitative approach, construction of a provisional model via scenario technique, followed by communicative validation (including interested public, n=100, preference finding, and identification of patient-oriented quality aims for follow-up. Quantitative data from questionnaires and chart review (as sociodemographic data, nonresponder analysis, and preference rating are worked up for descriptive statistics. The results provide a platform for the development of future multidisciplinary transitional intervention programs in orphan diseases.

  15. Role of Provisional Fixation of Fracture Fragments By Steinmann-Pin and Technical Tips in Proximal Femoral Nailing for Intertrochanteric Fracture.

    Science.gov (United States)

    Jain, Mohit J; Mavani, Kinjal J; Patel, Dhaval

    2017-06-01

    Proximal Femoral Nailing (PFN) in Intertrochanteric Fractures (IF) is becoming the choice of implant due to better biomechanics and prevention of varus collapse associated with Dynamic Hip Screw (DHS). Technical difficulties and implant related complications are yet to be addressed. To understand the technical difficulties involved in PFN and role of provisional fixation of fracture by Steinmann-pin. In this study, 55 patients presented to a tertiary trauma center in India with trochanteric fractures from April 2010 to March 2012 were included and treated with PFN. All patients were followed-up for two years and final outcome assessment included shortening, neck shaft angle and Harris Hip Score was done. In all except one, neck shaft angle greater than 130° was achieved and also maintained in the final follow up (Mean 131.1°). All fractures were united with mean shortening of 3.6 mm and average Harris Hip Score of 91 after two years. There were five complications which included one shortening, two varus collapses, one backed out screws and one reverse Z effect. Though PFN is technically challenging, with proper technique, gives excellent results with negligible varus collapse even in unstable fractures. Three most important technical aspects are achieving good non-varus reduction, inserting nail correctly and accurate placement of lag screws. The technique of provisional fixation of fracture fragments by Steinmann-pin significantly helps in achieving these and reduces the risk of implant failure.

  16. Kissing balloon or sequential dilation of the side branch and main vessel for provisional stenting of bifurcations: lessons from micro-computed tomography and computational simulations.

    Science.gov (United States)

    Foin, Nicolas; Torii, Ryo; Mortier, Peter; De Beule, Mathieu; Viceconte, Nicola; Chan, Pak Hei; Davies, Justin E; Xu, Xiao Yun; Krams, Rob; Di Mario, Carlo

    2012-01-01

    This study sought to evaluate post-dilation strategies in bifurcation stenting. In bifurcation stenting practice, it is still controversial how post-dilation should be performed and whether the kissing balloon (KB) technique is mandatory when only the main vessel (MV) receives a stent. A series of drug-eluting stents (DES) (n = 26) were deployed in a coronary bifurcation model following a provisional approach. After the deployment of the stent in the MV, post-dilation with the KB technique was compared with a 2-step, sequential post-dilation of the side branch (SB) and MV without kissing. The percentage of the SB lumen area free of stent struts was similar after KB (79.1 ± 8.7%) and after the 2-step sequence (74.4 ± 11.6%, p = 0.25), a considerable improvement compared with MV stenting only without dilation of the stent at the SB ostium (30.8 ± 7.8%, p stress concentration proximal to the SB. KB also led to a higher risk of incomplete stent apposition at the proximal stent edge (30.7 ± 26.4% vs. 2.8 ± 9.6% for 2-step, p = 0.0016). Sequential 2-step post-dilation of the SB and MV may offer a simpler and more efficient alternative to final KB technique for provisional stenting of bifurcations. Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  17. A comparison of two methods of removing zinc oxide-eugenol provisional cement residue from the internal surface of cast restorations.

    Science.gov (United States)

    Mosharraf, Ramin; Soleimani, Bahram; Sanaee-Nasab, Mehdi

    2009-05-01

    Remnants of provisional cement on the internal surface of cast restorations can have an adverse effect on the performance of the definitive luting agent. The purpose of this study was to evaluate the effect of eugenol-containing temporary cement removal by an ultrasonic or an organic solvent on the retentive strength of metallic rings cemented to amalgam cores using zinc phosphate cement. A total of 36 cylindrical amalgam cores measuring 5.9 x 6 mm were made by condensing amalgam in brass molds for use in this in vitro study. Thirty-six cylindrical spaces measuring 6 x 6 mm were machined in the center of cast rods of Rexillium III alloy to create simulated retainers. The amalgam cores were divided into two groups and provisionally cemented in these cylindrical spaces (retainers) using zinc oxide-eugenol cement. After separation of the cores from the retainers, one group was cleaned with an ultrasonic cleaning device with water and the other group was cleaned with Solitine organic solvent. All specimens were then cemented with zinc phosphate cement and the samples were stored at 100% humidity in a 37 degrees C water bath after which they were tested with a DARTEK testing machine at a 0.02 cm/minute cross head speed. The data were analyzed using the Independent t-test. The statistical analysis revealed a significant difference between the two groups (pcleaning the internal surface of cast restorations, the ultrasonic cleaning method is more effective for removing zinc-oxide temporary cement.

  18. Connection between maximum-work and maximum-power thermal cycles

    OpenAIRE

    Gonzalez-Ayala, Julian; Arias-Hernandez, L. A.; Angulo-Brown, F.

    2013-01-01

    We propose a new connection between maximum-power Curzon-Ahlborn thermal cycles and maximum-work reversible cycles. This linkage is built through a mapping between the exponents of a class of heat transfer laws and the exponents of a family of heat capacities depending on temperature. This connection leads to the recovery of known results and to a wide and interesting set of new results for a class of thermal cycles. Among other results we find that it is possible to use analytically closed e...

  19. Legal Quality, Inequality, and Tolerance

    DEFF Research Database (Denmark)

    Bjørnskov, Christian

    2004-01-01

    Previous findings suggest that income inequality leads to lower legal quality. This paper argues that voters' tolerance of inequality exerts an additional influence. Empirical findings suggest that inequality leads to lower legal quality due to its effect on trust while the tolerance of inequality...

  20. Legal Quality, Inequality, and Tolerance

    DEFF Research Database (Denmark)

    Bjørnskov, Christian

    Previous findings suggest that income inequality leads to lower legal quality. This paper argues that voters' tolerance of inequality exerts an additional influence. Empirical findings suggest that inequality leads to lower legal quality due to its effect on trust while the tolerance of inequality...

  1. Tolerance Issue in Kazakh Culture

    Science.gov (United States)

    Aubakirova, Saltanat S.; Ismagambetova, Zukhra N.; Karabayeva, Aliya G.; Rysbekova, Shamshiya S.; Mirzabekova, Alma Sh.

    2016-01-01

    In this article the authors reveal the basic cultural mechanisms that influence the formation of the tolerance strategy in Kazakh and Kazakhstan society, show its basic directions, as well as its importance for the modern Kazakhstan society and the formation of intercultural communication with foreign countries. Tolerance is a necessary element of…

  2. Glucose tolerance test - non-pregnant

    Science.gov (United States)

    Oral glucose tolerance test - non-pregnant; OGTT - non-pregnant; Diabetes - glucose tolerance test; Diabetic - glucose tolerance test ... The most common glucose tolerance test is the oral glucose tolerance test (OGTT). Before the test begins, a sample of blood will be ...

  3. Maximum likelihood continuity mapping for fraud detection

    Energy Technology Data Exchange (ETDEWEB)

    Hogden, J.

    1997-05-01

    The author describes a novel time-series analysis technique called maximum likelihood continuity mapping (MALCOM), and focuses on one application of MALCOM: detecting fraud in medical insurance claims. Given a training data set composed of typical sequences, MALCOM creates a stochastic model of sequence generation, called a continuity map (CM). A CM maximizes the probability of sequences in the training set given the model constraints, CMs can be used to estimate the likelihood of sequences not found in the training set, enabling anomaly detection and sequence prediction--important aspects of data mining. Since MALCOM can be used on sequences of categorical data (e.g., sequences of words) as well as real valued data, MALCOM is also a potential replacement for database search tools such as N-gram analysis. In a recent experiment, MALCOM was used to evaluate the likelihood of patient medical histories, where ``medical history`` is used to mean the sequence of medical procedures performed on a patient. Physicians whose patients had anomalous medical histories (according to MALCOM) were evaluated for fraud by an independent agency. Of the small sample (12 physicians) that has been evaluated, 92% have been determined fraudulent or abusive. Despite the small sample, these results are encouraging.

  4. Visual tracking by separability-maximum boosting

    Science.gov (United States)

    Hou, Jie; Mao, Yao-bin; Sun, Jin-sheng

    2013-10-01

    Recently, visual tracking has been formulated as a classification problem whose task is to detect the object from the scene with a binary classifier. Boosting based online feature selection methods, which adopt the classifier to appearance changes by choosing the most discriminative features, have been demonstrated to be effective for visual tracking. A major problem of such online feature selection methods is that an inaccurate classifier may give imprecise tracking windows. Tracking error accumulates when the tracker trains the classifier with misaligned samples and finally leads to drifting. Separability-maximum boosting (SMBoost), an alternative form of AdaBoost which characterizes the separability between the object and the scene by their means and covariance matrices, is proposed. SMBoost only needs the means and covariance matrices during training and can be easily adopted to online learning problems by estimating the statistics incrementally. Experiment on UCI machine learning datasets shows that SMBoost is as accurate as offline AdaBoost, and significantly outperforms Oza's online boosting. Accurate classifier stabilizes the tracker on challenging video sequences. Empirical results also demonstrate improvements in term of tracking precision and speed, comparing ours to those state-of-the-art ones.

  5. Maximum Margin Clustering of Hyperspectral Data

    Science.gov (United States)

    Niazmardi, S.; Safari, A.; Homayouni, S.

    2013-09-01

    In recent decades, large margin methods such as Support Vector Machines (SVMs) are supposed to be the state-of-the-art of supervised learning methods for classification of hyperspectral data. However, the results of these algorithms mainly depend on the quality and quantity of available training data. To tackle down the problems associated with the training data, the researcher put effort into extending the capability of large margin algorithms for unsupervised learning. One of the recent proposed algorithms is Maximum Margin Clustering (MMC). The MMC is an unsupervised SVMs algorithm that simultaneously estimates both the labels and the hyperplane parameters. Nevertheless, the optimization of the MMC algorithm is a non-convex problem. Most of the existing MMC methods rely on the reformulating and the relaxing of the non-convex optimization problem as semi-definite programs (SDP), which are computationally very expensive and only can handle small data sets. Moreover, most of these algorithms are two-class classification, which cannot be used for classification of remotely sensed data. In this paper, a new MMC algorithm is used that solve the original non-convex problem using Alternative Optimization method. This algorithm is also extended for multi-class classification and its performance is evaluated. The results of the proposed algorithm show that the algorithm has acceptable results for hyperspectral data clustering.

  6. MAXIMUM MARGIN CLUSTERING OF HYPERSPECTRAL DATA

    Directory of Open Access Journals (Sweden)

    S. Niazmardi

    2013-09-01

    Full Text Available In recent decades, large margin methods such as Support Vector Machines (SVMs are supposed to be the state-of-the-art of supervised learning methods for classification of hyperspectral data. However, the results of these algorithms mainly depend on the quality and quantity of available training data. To tackle down the problems associated with the training data, the researcher put effort into extending the capability of large margin algorithms for unsupervised learning. One of the recent proposed algorithms is Maximum Margin Clustering (MMC. The MMC is an unsupervised SVMs algorithm that simultaneously estimates both the labels and the hyperplane parameters. Nevertheless, the optimization of the MMC algorithm is a non-convex problem. Most of the existing MMC methods rely on the reformulating and the relaxing of the non-convex optimization problem as semi-definite programs (SDP, which are computationally very expensive and only can handle small data sets. Moreover, most of these algorithms are two-class classification, which cannot be used for classification of remotely sensed data. In this paper, a new MMC algorithm is used that solve the original non-convex problem using Alternative Optimization method. This algorithm is also extended for multi-class classification and its performance is evaluated. The results of the proposed algorithm show that the algorithm has acceptable results for hyperspectral data clustering.

  7. Theoretical Estimate of Maximum Possible Nuclear Explosion

    Science.gov (United States)

    Bethe, H. A.

    1950-01-31

    The maximum nuclear accident which could occur in a Na-cooled, Be moderated, Pu and power producing reactor is estimated theoretically. (T.R.H.) 2O82 Results of nuclear calculations for a variety of compositions of fast, heterogeneous, sodium-cooled, U-235-fueled, plutonium- and power-producing reactors are reported. Core compositions typical of plate-, pin-, or wire-type fuel elements and with uranium as metal, alloy, and oxide were considered. These compositions included atom ratios in the following range: U-23B to U-235 from 2 to 8; sodium to U-235 from 1.5 to 12; iron to U-235 from 5 to 18; and vanadium to U-235 from 11 to 33. Calculations were performed to determine the effect of lead and iron reflectors between the core and blanket. Both natural and depleted uranium were evaluated as the blanket fertile material. Reactors were compared on a basis of conversion ratio, specific power, and the product of both. The calculated results are in general agreement with the experimental results from fast reactor assemblies. An analysis of the effect of new cross-section values as they became available is included. (auth)

  8. 49 CFR 230.24 - Maximum allowable stress.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Maximum allowable stress. 230.24 Section 230.24... Allowable Stress § 230.24 Maximum allowable stress. (a) Maximum allowable stress value. The maximum allowable stress value on any component of a steam locomotive boiler shall not exceed 1/4 of the ultimate...

  9. Maximum smoothed likelihood estimation and smoothed maximum likelihood estimation in the current status model

    NARCIS (Netherlands)

    Groeneboom, P.; Jongbloed, G.; Witte, B.I.

    2010-01-01

    We consider the problem of estimating the distribution function, the density and the hazard rate of the (unobservable) event time in the current status model. A well studied and natural nonparametric estimator for the distribution function in this model is the nonparametric maximum likelihood

  10. Half-width at half-maximum, full-width at half-maximum analysis for ...

    Indian Academy of Sciences (India)

    In the present study, HWHM (half-width at half-maximum) of the resultant PSF has been defined to characterize the resolution of the detection system. ... Department of Physics, University College of Science, Osmania University, Hyderabad 500 007, India; Department of Humanities & Sciences, C.M.R. Institute of Technology ...

  11. Comparative evaluation of marginal leakage of provisional crowns cemented with different temporary luting cements: In vitro study

    Directory of Open Access Journals (Sweden)

    Sheen Juneja Arora

    2016-01-01

    Conclusion: The temporary cements with eugenol showed more microleakage than those without eugenol. SC-10 crowns showed more microleakage compared to Protemp 4 crowns. SC-10 crowns cemented with Kalzinol showed maximum microleakage and Protemp 4 crowns cemented with HY bond showed least microleakage.

  12. Cosmic shear measurement with maximum likelihood and maximum a posteriori inference

    Science.gov (United States)

    Hall, Alex; Taylor, Andy

    2017-06-01

    We investigate the problem of noise bias in maximum likelihood and maximum a posteriori estimators for cosmic shear. We derive the leading and next-to-leading order biases and compute them in the context of galaxy ellipticity measurements, extending previous work on maximum likelihood inference for weak lensing. We show that a large part of the bias on these point estimators can be removed using information already contained in the likelihood when a galaxy model is specified, without the need for external calibration. We test these bias-corrected estimators on simulated galaxy images similar to those expected from planned space-based weak lensing surveys, with promising results. We find that the introduction of an intrinsic shape prior can help with mitigation of noise bias, such that the maximum a posteriori estimate can be made less biased than the maximum likelihood estimate. Second-order terms offer a check on the convergence of the estimators, but are largely subdominant. We show how biases propagate to shear estimates, demonstrating in our simple set-up that shear biases can be reduced by orders of magnitude and potentially to within the requirements of planned space-based surveys at mild signal-to-noise ratio. We find that second-order terms can exhibit significant cancellations at low signal-to-noise ratio when Gaussian noise is assumed, which has implications for inferring the performance of shear-measurement algorithms from simplified simulations. We discuss the viability of our point estimators as tools for lensing inference, arguing that they allow for the robust measurement of ellipticity and shear.

  13. General tolerances - Part 1: Tolerances for linear and angular dimensions without individual tolerance indications

    CERN Document Server

    International Organization for Standardization. Geneva

    1989-01-01

    This part is intended to simplify drawing indications and specifies general tolerances in four tolerance classes. It applies to the dimensions of workpieces that are produced by metal removal or are formed from sheet metal. It contains three tables and an informative annex with regard to concepts behind general tolerancing of dimensions.

  14. General tolerances -- Part 2: Geometrical tolerances for features without individual tolerance indications

    CERN Document Server

    International Organization for Standardization. Geneva

    1989-01-01

    This part is intended to simplify drawing indications and specifies general tolerances in three tolerance classes. It mainly applies to features which are produced by removal of material. It contains tour tables and an informative annex A with regard to concepts behind general tolerancing of dimensions, as well as an informative annex B with further information.

  15. Density maximum and polarizable models of water

    Science.gov (United States)

    Kiss, Péter T.; Baranyai, András

    2012-08-01

    To estimate accurately the density of water over a wide range of temperatures with a density maximum at 4 °C is one of the most stringent tests of molecular models. The shape of the curve influences the ability to describe critical properties and to predict the freezing temperature. While it was demonstrated that with a proper parameter fit nonpolarizable models can approximate this behavior accurately, it is much more difficult to do this for polarizable models. We provide a short overview of ρ-T diagrams for existing models, then we give an explanation of this difficulty. We present a version of the BK model [A. Baranyai and P. T. Kiss, J. Chem. Phys. 133, 144109 (2010), 10.1063/1.3490660; A. Baranyai and P. T. Kiss, J. Chem. Phys. 135, 234110 (2011)], 10.1063/1.3670962 which is capable to predict the density of water over a wide range of temperature. The BK model uses the charge-on-spring method with three Gaussian charges. Since the experimental dipole moment and the geometry is fixed, and the quadrupole moment is approximated by a least mean square procedure, parameters of the repulsion and dispersive attraction forces remained as free tools to match experimental properties. Relying on a simplified but plausible justification, the new version of the model uses repulsion and attraction as functions of the induced dipole moment of the molecule. The repulsive force increases, while the attractive force decreases with the size of the molecular dipole moment. At the same time dipole moment dependent dispersion forces are taking part in the polarization of the molecule. This scheme iterates well and, in addition to a reasonable density-temperature function, creates dipole distributions with accurate estimation of the dielectric constant of the liquid.

  16. 40 CFR 1042.140 - Maximum engine power, displacement, power density, and maximum in-use engine speed.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Maximum engine power, displacement... Maximum engine power, displacement, power density, and maximum in-use engine speed. This section describes how to determine the maximum engine power, displacement, and power density of an engine for the...

  17. Tolerable Time-Varying Overflow on Grass-Covered Slopes

    Directory of Open Access Journals (Sweden)

    Steven A. Hughes

    2015-03-01

    Full Text Available Engineers require estimates of tolerable overtopping limits for grass-covered levees, dikes, and embankments that might experience steady overflow. Realistic tolerance estimates can be used for both resilient design and risk assessment. A simple framework is developed for estimating tolerable overtopping on grass-covered slopes caused by slowly-varying (in time overtopping discharge (e.g., events like storm surges or river flood waves. The framework adapts the well-known Hewlett curves of tolerable limiting velocity as a function of overflow duration. It has been hypothesized that the form of the Hewlett curves suggests that the grass erosion process is governed by the flow work on the slope above a critical threshold velocity (referred to as excess work, and the tolerable erosional limit is reached when the cumulative excess work exceeds a given value determined from the time-dependent Hewlett curves. The cumulative excess work is expressed in terms of overflow discharge above a critical discharge that slowly varies in time, similar to a discharge hydrograph. The methodology is easily applied using forecast storm surge hydrographs at specific locations where wave action is minimal. For preliminary planning purposes, when storm surge hydrographs are unavailable, hypothetical equations for the water level and overflow discharge hydrographs are proposed in terms of the values at maximum overflow and the total duration of overflow. An example application is given to illustrate use of the methodology.

  18. Base reinforcement of the provisional platform for the construction of piles screen on the Flix reservoir (Tarragona); Refuerzo de based de la plataforma provisional para la ejecucion de pantalla de pilotes en el embalse de Flix (Tarragona)

    Energy Technology Data Exchange (ETDEWEB)

    Amo Sanz, P.; Diego Pereda, I.; Santalla Prieto, J.

    2014-02-01

    Decontamination works on Flix reservoir aimed at the removal of accumulated debris in the bed of the river Ebro, as result of historical discharge of pollutants by a chemical complex located there. The Flix reservoir currently retains in his base a lot of cubic meters of sludge from the solid fraction of the discharge of the aforementioned complex that sits on the right bank ( a non-negligible volume of alluvial substrate potentially affected by pollution from the sludge must be considered). The contaminants belong to there main groups: organo chlorines, heavy metals (particularly mercury) and radionuclides. they are in high concentrations, capable of transmitting contamination to the sediments and basement of the reservoir and the water flowing through the river. In the case of water, that transmission occurs in fact, and there is a register of episodes that have exceeded the limits of tolerance of aggressive components contained in the ecosystem. (Author)

  19. Single-Tooth Rehabilitations Supported by Dental Implants Used in an Immediate-Provisionalization Protocol: Report on Long-Term Outcome with Retrospective Follow-Up.

    Science.gov (United States)

    Maló, Paulo; de Araújo Nobre, Miguel; Lopes, Armando; Ferro, Ana; Gravito, Inês

    2015-10-01

    There is a need for long-term studies evaluating the outcome of single-tooth rehabilitations supported by dental implants in immediate loading. To report the long-term outcome (in excess of 5 years) of single-tooth rehabilitations supported by dental implants in an immediate-provisionalization protocol. This retrospective cohort study included 332 consecutive patients (189 females and 143 males) with an average age of 47 years (range: 16 to 82 years) who were rehabilitated between 1996 and 2006 with 594 single crowns supported by dental implants in immediate loading. Implant success rates were calculated based on implant function and using life tables. Marginal bone levels were measured at 5 and 10 years. Mechanical and biological complications were calculated for the follow-up period between implant insertion and 5 years and every 6 months thereafter. Fifty-four patients dropped out of the study (16.5%). Nineteen patients lost a total of 25 implants (n = 23 in the maxilla; n = 2 in the mandible), rendering a cumulative survival rate of 95.7% at both 5 and 10 years of follow-up. The mean marginal bone levels were 1.56 mm (standard deviation 0.78 mm) and 1.75 mm (standard deviation 0.29 mm) at 5 and 10 years of follow-up. Mechanical complications occurred in 83 patients and 116 implants (19.5%) up to the 10-year follow-up, namely prosthetic screw loosening (2.4%), abutment complications (4.4%), fracture of provisional crowns (9.6%), and fracture of definitive ceramic crowns (3.5%). Biological complications occurred in 58 patients and 79 implants (13.3%) up to the 10-year follow-up, with the majority consisting in peri-implant pathology. Considering the high survival rates and stable marginal bone levels after 10 years, it can be concluded within the limitations of the present study that replacement of single teeth with dental implants in an immediate-provisionalization protocol is a viable and safe treatment option for both maxilla and mandible.

  20. Provisional versus elective two-stent strategy for unprotected true left main bifurcation lesions: Insights from a FAILS-2 sub-study.

    Science.gov (United States)

    Kawamoto, Hiroyoshi; Chieffo, Alaide; D'Ascenzo, Fabrizio; Jabbour, Richard J; Naganuma, Toru; Cerrato, Enrico; Ugo, Fabrizio; Pavani, Marco; Varbella, Ferdinando; Boccuzzi, Giacomo; Pennone, Mauro; Garbo, Roberto; Conrotto, Federico; Biondi-Zoccai, Giuseppe; D'Amico, Maurizio; Moretti, Claudio; Escaned, Javier; Gaita, Fiorenzo; Nakamura, Sunao; Colombo, Antonio

    2018-01-01

    This study sought to investigate the optimal percutaneous coronary intervention (PCI) strategy for true unprotected left main coronary artery (ULMCA) bifurcations. The FAILS-2 was a retrospective multi-center study including patients with ULMCA disease treated with second-generation drug-eluting stents. Of these, we compared clinical outcomes of a provisional strategy (PS; n=216) versus an elective two-stent strategy (E2S; n=161) for true ULMCA bifurcations. The primary endpoint was the incidence of major adverse cardiac events (MACEs) at 3-years. We further performed propensity-score adjustment for clinical outcomes. There were no significant differences between the groups in terms of patient and lesion characteristics. 9.7% of patients in the PS group crossed over to a provisional two-stent strategy. MACEs were not significantly different between groups (MACE at 3-year; PS 28.1% vs. E2S 28.9%, adjusted p=0.99). The rates of target lesion revascularization (TLR) on the circumflex artery (LCX) were numerically high in the E2S group (LCX-TLR at 3-years; PS 11.8% vs. E2S 16.6%, adjusted p=0.51). E2S was associated with a comparable MACE rate to PS for true ULMCA bifurcations. The rates of LCX-TLR tended to be higher in the E2S group although there was no statistical significance. This study sought to compare the clinical outcomes of a provisional strategy (PS) with an elective two-stent strategy (E2S) for the treatment of true unprotected left main coronary artery bifurcations. 377 Patients (PS 216 vs. E2S 161 patients) were evaluated, and 9.7% in the PS group crossed over to a two-stent strategy. E2S was associated with a similar major adverse cardiac event rate at 3-years when compared to the PS strategy (PS 28.1% vs. E2S 28.9%, p=0.99). However, the left circumflex artery TLR rate at 3-year tended to be higher in the E2S group (PS 11.8% vs. E2S 16.6%, p=0.51). Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Instrucción provisional para el empleo de puntos de soldadura eléctrica por resistencia en las construcciones de acero

    Directory of Open Access Journals (Sweden)

    Batanero, J.

    1963-06-01

    Full Text Available As an initial measure to generalise spot welding in the field of metallic structures, the Deutsche Ausschuss fur Stahlbau has issued a provisional specification, of which a full translation is given in this paper. The Specification includes a number of rules, as well as comments and recommendations on the method of establishing the aptitude of a given firm, or a workshop, to practise this spot welding technique. The various chapters of these Specifications give an account of the fundamental calculation principles and the best practise that should be followed in this type of welding. Advise is also offered on the initial care to be taken in applying these principles and specifications in actual practice. The comments that follow serve to clarify and explain the reasons which underlie the various conditions specified in this text. Finally, the recommendations on the method of establishing the aptitude of given workshops to undertake spot welding work are based on the following principle: the construction of structures with spot welded joints can only be entrusted to people who have attained a certain standard of skill, precisely because these structures are meant to be load bearing, and their real strength cannot be checked in practise, a posteriori, except by means of destruction tests. The full text of these Provisional Specifications will be given in three consecutive numbers of the magazine.La soldadura por resistencia es un medio de unión que, en ocasiones, puede resultar muy cómodo y económico. En las estructuras metálicas puras se ha venido empleando poco hasta ahora, aunque su utilización estaba bastante difundida en el empalme a tope de redondos, formación de parrillas de losas y tuberías, etc., con destino a las estructuras de hormigón. Sin embargo, las experiencias realizadas en los últimos años han demostrado que los puntos de soldadura por resistencia pueden constituir medios de unión que, bajo ciertas condiciones

  2. Evaluation of bond strength between grooved titanium alloy implant abutments and provisional veneering materials after surface treatment of the abutments: An in vitro study

    Directory of Open Access Journals (Sweden)

    Gowtham Venkat

    2017-01-01

    Full Text Available Introduction: Titanium has become the material of choice with greater applications in dental implants. The success of the dental implant does not only depend on the integration of the implant to the bone but also on the function and longevity of the superstructure. The clinical condition that demands long-term interim prosthesis is challenging owing to the decreased bond between the abutment and the veneering material. Hence, various surface treatments are done on the abutments to increase the bond strength. Aim: This study aimed to evaluate the bond strength between the abutment and the provisional veneering materials by surface treatments such as acid etching, laser etching, and sand blasting of the abutment. Materials and Methods: Forty titanium alloy abutments of 3 mm diameter and 11 mm height were grouped into four groups with ten samples. Groups A, B, C, and D are untreated abutments, sand blasted with 110 μm aluminum particles, etched with 1% hydrofluoric acid and 30% nitric acid, and laser etched with Nd: YAG laser, respectively. Provisional crowns were fabricated with bis-acrylic resin and cemented with noneugenol temporary luting cement. The shear bond strength was measured in universal testing machine using modified Shell–Nielsen shear test after the cemented samples were stored in water at 25°C for 24 h. Load was applied at a constant cross head speed of 5 mm/min until a sudden decrease in resistance indicative of bond failure was observed. The corresponding force values were recorded, and statistical analysis was done using one-way ANOVA and Newman–Keuls post hoc test. Results: The laser-etched samples showed higher bond strength. Conclusion: Among the three surface treatments, laser etching showed the highest bond strength between titanium alloy implant abutment and provisional restorations. The sand-blasted surfaces demonstrated a significant difference in bond strength compared to laser-etched surfaces. The results of this

  3. Immediate loading in the maxilla using flapless surgery, implants placed in predetermined positions, and prefabricated provisional restorations: a retrospective 3-year clinical study.

    Science.gov (United States)

    Rocci, Antonio; Martignoni, Massimiliano; Gottlow, Jan

    2003-01-01

    Immediate loading of dental implants shortens the treatment time and makes it possible to give the patient an esthetic appearance during the whole treatment period. The aim of the present study was to evaluate an immediate-loading treatment protocol, which included flapless surgery, implants placed in predetermined positions and connected to prefabricated provisional restorations, and the 3-year clinical results. A total of 97 Brånemark System Mk IV implants (Nobel Biocare AB, Gothenburg, Sweden) with a machined surface were inserted in the maxillas of 46 patients. A presurgical three-dimensional model of the patients' soft tissue and underlying alveolar bone anatomy was created, which allowed the clinician to place the implants in predetermined positions and connect them to prefabricated provisional restorations. A surgical template with drilling guides corresponding to each implant was used. The apical part of the master guide was equipped with a circular "mucotome," which punched out a 5 mm hole in the mucosa to eliminate the need for flap elevation. The patients received 25 fixed partial prostheses and 27 single-tooth restorations. Bone quality and quantity were assessed. Radiographic examinations were performed on the day of surgery/loading and at the 1-, 2-, and 3-year follow-up visits. All implant sites showed intact buccal and lingual bone walls during surgery, confirming the accuracy of the bone-mapping procedure. The prefabricated temporary restorations fitted, meaning that the implants were positioned clinically in the same way as on the cast. Nine implants in eight patients failed during the first 8 weeks of loading. This resulted in a cumulative survival rate of 91% after 3 years of prosthetic load. The survival rate of splinted implants was 94%. The number of failed implants was significantly higher in cases of single-tooth replacements and placement in soft bone sites and smokers. The failed implants were successfully replaced according to a two

  4. Mechanical tolerance stackup and analysis

    CERN Document Server

    Fischer, Bryan R

    2011-01-01

    Use Tolerance Analysis Techniques to Avoid Design, Quality, and Manufacturing Problems Before They Happen Often overlooked and misunderstood, tolerance analysis is a critical part of improving products and their design processes. Because all manufactured products are subject to variation, it is crucial that designers predict and understand how these changes can affect form, fit, and function of parts and assemblies--and then communicate their findings effectively. Written by one of the developers of ASME Y14.5 and other geometric dimension and tolerancing (GD&T) standards, Mechanical Tolerance

  5. Advanced cloud fault tolerance system

    Science.gov (United States)

    Sumangali, K.; Benny, Niketa

    2017-11-01

    Cloud computing has become a prevalent on-demand service on the internet to store, manage and process data. A pitfall that accompanies cloud computing is the failures that can be encountered in the cloud. To overcome these failures, we require a fault tolerance mechanism to abstract faults from users. We have proposed a fault tolerant architecture, which is a combination of proactive and reactive fault tolerance. This architecture essentially increases the reliability and the availability of the cloud. In the future, we would like to compare evaluations of our proposed architecture with existing architectures and further improve it.

  6. Stepwise iterative maximum likelihood clustering approach.

    Science.gov (United States)

    Sharma, Alok; Shigemizu, Daichi; Boroevich, Keith A; López, Yosvany; Kamatani, Yoichiro; Kubo, Michiaki; Tsunoda, Tatsuhiko

    2016-08-24

    Biological/genetic data is a complex mix of various forms or topologies which makes it quite difficult to analyze. An abundance of such data in this modern era requires the development of sophisticated statistical methods to analyze it in a reasonable amount of time. In many biological/genetic analyses, such as genome-wide association study (GWAS) analysis or multi-omics data analysis, it is required to cluster the plethora of data into sub-categories to understand the subtypes of populations, cancers or any other diseases. Traditionally, the k-means clustering algorithm is a dominant clustering method. This is due to its simplicity and reasonable level of accuracy. Many other clustering methods, including support vector clustering, have been developed in the past, but do not perform well with the biological data, either due to computational reasons or failure to identify clusters. The proposed SIML clustering algorithm has been tested on microarray datasets and SNP datasets. It has been compared with a number of clustering algorithms. On MLL datasets, SIML achieved highest clustering accuracy and rand score on 4/9 cases; similarly on SRBCT dataset, it got for 3/5 cases; on ALL subtype it got highest clustering accuracy for 5/7 cases and highest rand score for 4/7 cases. In addition, SIML overall clustering accuracy on a 3 cluster problem using SNP data were 97.3, 94.7 and 100 %, respectively, for each of the clusters. In this paper, considering the nature of biological data, we proposed a maximum likelihood clustering approach using a stepwise iterative procedure. The advantage of this proposed method is that it not only uses the distance information, but also incorporate variance information for clustering. This method is able to cluster when data appeared in overlapping and complex forms. The experimental results illustrate its performance and usefulness over other clustering methods. A Matlab package of this method (SIML) is provided at the web-link http://www.riken.jp/en/research/labs/ims/med_sci_math/ .

  7. Freeze-Tolerant Condensers

    Science.gov (United States)

    Crowley, Christopher J.; Elkouhk, Nabil

    2004-01-01

    Two condensers designed for use in dissipating heat carried by working fluids feature two-phase, self-adjusting configurations such that their working lengths automatically vary to suit their input power levels and/or heat-sink temperatures. A key advantage of these condensers is that they can function even if the temperatures of their heat sinks fall below the freezing temperatures of their working fluids and the fluids freeze. The condensers can even be restarted from the frozen condition. The top part of the figure depicts the layout of the first condenser. A two-phase (liquid and vapor) condenser/vapor tube is thermally connected to a heat sink typically, a radiatively or convectively cooled metal panel. A single-phase (liquid) condensate-return tube (return artery) is also thermally connected to the heat sink. At intervals along their lengths, the condenser/vapor tube and the return artery are interconnected through porous plugs. This condenser configuration affords tolerance of freezing, variable effective thermal conductance (such that the return temperature remains nearly constant, independently of the ultimate sink temperature), and overall pressure drop smaller than it would be without the porous interconnections. An additional benefit of this configuration is that the condenser can be made to recover from the completely frozen condition either without using heaters, or else with the help of heaters much smaller than would otherwise be needed. The second condenser affords the same advantages and is based on a similar principle, but it has a different configuration that affords improved flow of working fluid, simplified construction, reduced weight, and faster recovery from a frozen condition.

  8. Antibiotic tolerance and microbial biofilms

    DEFF Research Database (Denmark)

    Folkesson, Anders

    Increased tolerance to antimicrobial agents is thought to be an important feature of microbes growing in biofilms. We study the dynamics of antibiotic action within hydrodynamic flow chamber biofilms of Escherichia coli and Pseudomonas aeruginosa using isogenic mutants and fluorescent gene...... expression reporters and we address the question of how biofilm organization affects antibiotic susceptibility. The dynamics of microbial killing is monitored by viable count determination, and confocal laser microscopy. Our work shows that the apparent increased antibiotic tolerance is due to the formation...... of antibiotic tolerant subpopulations within the biofilm. The formation of these subpopulations is highly variable and dependent on the antibiotic used, the biofilm structural organization and the induction of specific tolerance mechanisms....

  9. The management of an edentulous maxilla using a CAD/CAM-guided immediately loaded provisional implant prosthesis with screw-retained and cement-retained abutments: a clinical report.

    Science.gov (United States)

    Tee-Khin, Neo; Cheng, Ansgar C; Lee, Helena; Wee, Alvin G

    2009-12-01

    Functional rehabilitation of edentulous jaws using a CAD/CAM-guided implant protocol is commonly recommended as a definitive treatment modality. A patient with an edentulous maxilla received 7 endosseous implants using a CAD/CAM surgical template. A provisional maxillary acrylic resin fixed complete denture was connected immediately after implant placement using a combination of screw-retained and cement-retained abutments.

  10. Spiritual well-being and quality of life among Icelanders receiving palliative care: data from Icelandic pilot-testing of a provisional measure of spiritual well-being from the European Organisation for Research and Treatment of Cancer.

    Science.gov (United States)

    Asgeirsdottir, G H; Sigurdardottir, V; Gunnarsdottir, S; Sigurbjörnsson, E; Traustadottir, R; Kelly, E; Young, T; Vivat, B

    2017-03-01

    Palliative care focuses on improving quality of life (QoL). This study examined the feasibility of the Icelandic version of a provisional European Organisation for Research and Treatment of Cancer (EORTC) measure of spiritual well-being (SWB), and explored the relationship between SWB and QoL for palliative care patients in Iceland. Instruments from the EORTC were used: the provisional measure of SWB, which was undergoing pilot-testing in Iceland, and the EORTC QLQ C15-PAL. The correlation between scores was examined and descriptive statistics were used. Structured interviews explored feasibility. Thirty persons participated with average age 72 years. Belief in God or a higher power had the mean 3.33 on a 1-4 scale and the mean for overall SWB was 5.73 on a 1-7 scale. The mean score for global health/QoL was 59.4, physical functioning 48.5 and emotional functioning 78.9 on a 0-100 scale. Overall QoL was positively correlated with SWB showing r(30) = 0.386, P = 0.035. The participants found that answering the provisional EORTC QLQ-SWB prompted an emotional response and took the opportunity to discuss the subject. The provisional SWB measure was found relevant for the Icelandic context, and the study indicates that SWB and QoL are closely connected. © 2015 John Wiley & Sons Ltd.

  11. Development of functional foods for radiation workers - In vivo test on the effect of functional food for stem cell protection and preparing the provisional product

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Ho; Oh, Heon; Kim, Se Ra; Lee, Song Eun [Chonnam National University, Kwangju (Korea)

    2000-04-01

    We performed this study to determine (1) the effect of several oriental prescriptions as energy tonic (Chinese medical concept : Bu-Qi) or blood building (Chinese medical concept : Bu-Xie) decoction and its major ingredients, (2) the biological stability of irradiated Chinese medical prescriptions, and (3) the effect of several proposed prescriptions and its fractions on jejunal crypt survival (12 Gy), endogenous spleen colony formation(6.5 Gy), and apoptosis(2 Gy) in jejunal crypt cells of mice irradiated with high and low dose of gamma-irradiation. For the study of evaluation on the radioprotective effects of effective prescriptions, we tried the test on change of survival and hematological changes and finally we prepared the provisional product. 57 refs., 5 figs., 38 tabs. (Author)

  12. Immediate occluding definitive partial fixed prosthesis versus non-occluding provisional restorations - 4-month post-loading results from a pragmatic multicenter randomised controlled trial.

    Science.gov (United States)

    Heinemann, Friedhelm; Grufferty, Brendan; Papavasiliou, George; Dominiak, Marzena; García, Jaime Jiménez; Trullenque-Eriksson, Anna; Esposito, Marco

    2016-01-01

    To compare the clinical outcome of dental implants restored with definitive occluding partial fixed prostheses within 1 week, after implant placement with immediate non-occluding provisional restorations, which were to be replaced by definitive prostheses after 4 months. Fifty partially edentulous patients treated with one to three dental implants, at least 8.5 mm long and 4.0 mm wide inserted with a torque of at least 35 Ncm, were randomised in two groups of 25 patients each, to be immediately loaded with partial fixed prostheses. Patients of one group received one definitive screw-retained metal-ceramic prosthesis in occlusion within 1 week after placement. Patients of the other group received one non-occluding provisional acrylic reinforced prosthesis within 24 h after implant placement. Provisional prostheses were replaced after 4 months by definitive ones. The follow-up for all patients was 4-months post-loading. Outcome measures were prosthesis and implant failures, any complications, peri-implant marginal bone level changes, aesthetic evaluation by a clinician, patient satisfaction, chair time and number of visits at the dental office from implant placement to delivery of definitive restorations. No patient dropped out. Two immediately occlusally loaded implants with their related definitive prostheses (8%) failed early (difference in proportions = 0.08; 95% CI: -0.03 to 0.19; P = 0.490). Four complications occurred in the occlusal group versus one in the non-occlusal group; (difference in proportions = 0.12; 95% CI: -0.04 to 0.28; P = 0.349). Four months after loading, patients subjected to non-occlusal loading lost an average of 0.72 mm of peri-implant bone versus 0.99 mm of patients restored with occluding definitive partial fixed prostheses. There were no statistically significant differences for marginal bone level changes between the two groups (mean difference = -0.27 mm; 95% CI: -0.84 to 0.30; P = 0.349). The differences for aesthetic scores showed

  13. Where did the doctors go? A study of retention and migration of provisionally licensed international medical graduates practising in Newfoundland and Labrador between 1995 and 2006.

    Science.gov (United States)

    Audas, Rick; Ryan, Ann; Vardy, David

    2009-01-01

    More than any other Canadian province, Newfoundland and Labrador (NL) relies on provisionally licensed international medical graduates (PLIMGs) to provide primary health care, particularly in rural communities. However, turnover among PLIMGs is high, and this is expensive and disruptive to the populations they serve. We developed and analyzed a database that allowed us to quantify the turnover among PLIMGs and also to determine the Canadian destinations of PLIMGs who cease practising in NL. We found that about 1 in 5 PLIMGs remain in province for a period of 5 years and that those who emigrate within Canada are most likely to go to Ontario. Many PLIMGs cannot be tracked after they leave the province. We speculate that many PLIMGs are moving on to the more lucrative US market.

  14. Temperature tolerance of young-of-the-year cisco, Coregonus artedii

    Science.gov (United States)

    Edsall, Thomas A.; Colby, Peter J.

    1970-01-01

    Young-of-the-year ciscoes (Coregonus artedii) acclimated to 2, 5, 10, 20 and 25 C and tested for tolerance to high and low temperatures provide the first detailed description of the thermal tolerance of coregonids in North America. The upper ultimate lethal temperature of the young ciscoes was 26 C (6 C higher than the maximum sustained temperature tolerated by adult ciscoes in nature) and the ultimate lower lethal temperature approached 0 C (near that commonly tolerated in nature by adult ciscoes). The temperature of 26 C is slightly higher than the lowest ultimate upper lethal temperature recorded for North American freshwater fishes; however, published information on the depth distributions of fishes in the Great Lakes suggests that some of the other coregonids may be less tolerant of high temperatures than the cisco.

  15. Women’s G Tolerance

    Science.gov (United States)

    1986-08-01

    for the groups matched by age (70 pairs), weight sickness, uncomfortable feelings of distension in arms (26 pairs), and act~vity status (84 pairs...mass-spring-damper) s ,stem Straining G tolerance, being dpendent on skeletal having a resonant frequency above about I Hz. As muscular strength and...of the women’s G tolerance stud\\ scclic variations in muscular strength and endurance. was below 0.1 Hz (11), the production of any significant

  16. Behavioral Tolerance to Anticholinergic Agents

    Science.gov (United States)

    1986-11-20

    Medicine , 47, 137-141. 7. Kurtz, P.J. (1977) Behavioral and biochemical effects of the carbamate insecticide, mobam. Pharmacology Biochemistry & Behavior...tolerance to marihuana in rats. Pharmacology Biochemistry and Behavior, 1, 73-76. 43 40. Olson, J. and Carder, B. (1974) Behavioral tolerance to... marihuana as a function of amount of prior training. Pharmacology Biochemistry and Behavior, 2, 243-247. 41. Sidman, M. (1960) Tactics of Scientific

  17. Provisional T-stenting and kissing balloon in the treatment of coronary bifurcation lesions: results of the French multicenter "TULIPE" study.

    Science.gov (United States)

    Brunel, Philippe; Lefevre, Thierry; Darremont, Olivier; Louvard, Yves

    2006-07-01

    In previous prospective studies, a strategy of (a) stenting of the main branch, (b) provisional T-stenting of the side branch, and (c) final kissing balloon inflation, was associated with high success and low target lesion revascularization (TLR) rates on the long-term. To examine the performance of this strategy in a multicenter study. Consecutive patients were treated at 14 French medical centers for de novo coronary bifurcation lesions with the same technique used. Immediate results and clinically-driven TLR at 7 months were examined. The mean reference diameters of the main and side branches were 3.2 +/- 0.6 mm and 2.4 +/- 0.5 mm, respectively. The side branch was stented in 34% of patients. A wave and 5 non-Qwaves MI (0.54% and 2.7%). At 7 months of follow-up, 3 patients (1.76%) had died, 1 suffered a non-Q-wave MI (0.59%), and 28 (15.88%) underwent TLR. By multivariate analysis, a lower left ventricular ejection fraction (OR: 0.934), moderate calcifications (OR: 7.86), and non-use of the "jailed" wire technique (OR: 4.26) were associated with reinterventions during follow-up. A strategy of provisional T-stenting with a tubular stent and final kissing balloon angioplasty for the treatment of coronary bifurcation lesions was safe and associated with a low TLR rate at 7 months. This strategy should be applicable to the new era of drug eluting stents. Copyright 2006 Wiley-Liss, Inc.

  18. Vaccination Coverage for Selected Vaccines, Exemption Rates, and Provisional Enrollment Among Children in Kindergarten - United States, 2016-17 School Year.

    Science.gov (United States)

    Seither, Ranee; Calhoun, Kayla; Street, Erica J; Mellerson, Jenelle; Knighton, Cynthia L; Tippins, Ashley; Underwood, J Michael

    2017-10-13

    State and local school vaccination requirements help protect students and communities against vaccine-preventable diseases (1). CDC reports vaccination coverage and exemption data for children attending kindergarten (kindergartners) collected by federally funded immunization programs in the United States.* The typical age range for kindergartners is 4-6 years. Although vaccination requirements vary by state (the District of Columbia [DC] is counted as a state in this report.), the Advisory Committee on Immunization Practices recommends that children in this age range have received, among other vaccinations, 5 doses of diphtheria, tetanus, and acellular pertussis vaccine (DTaP), 2 doses of measles, mumps, and rubella vaccine (MMR), and 2 doses of varicella vaccine (2). This report summarizes 2016-17 school year MMR, DTaP, and varicella vaccination coverage reported by immunization programs in 49 states, exemptions in 50 states, and kindergartners provisionally enrolled or within a grace period in 27 states. Median vaccination coverage† was 94.5% for the state-required number of doses of DTaP; 94.0% for 2 doses of MMR; and 93.8% for 2 doses of varicella vaccine. The median percentage of kindergartners with an exemption from at least one vaccine§ was 2.0%, similar to 2015-16 (1.9%). Median grace period and provisional enrollment was 2.0%. Vaccination coverage remains consistently high and exemptions low at state and national levels. Local-level vaccination coverage data provide opportunities for immunization programs to identify schools, districts, counties, or regions susceptible to vaccine-preventable diseases and for schools to address undervaccination through implementation of existing state and local vaccination policies (1) to protect communities through increased coverage.

  19. Long-term clinical outcomes for bifurcation treatment using a provisional T-stenting and double proximal optimization technique with Absorb bioresorbable scaffolds

    Directory of Open Access Journals (Sweden)

    Р. Д. Иванченко

    2017-04-01

    Full Text Available Aim. The article presents long-term outcomes of treatment of coronary artery bifurcation lesions by using bioresorbable vascular scaffolds and provisional T-stenting combined with double proximal optimization. Methods. 14 patients aged 44-80 years (mean age 61±6 years including 8 (57.14 % males underwent endovascular treatment of coronary artery bifurcation lesions by using Absorb bioresorbable vascular scaffolds (BVS. Clinical/instrumental analysis was carried out after 23.7±4.12 months. Angiographic examination was performed in 12 cases (85.71 %. 7 patients (50 % underwent optical coherent tomography. Results. 11 patients (78.57 were free of angina during long-term follow-up. 1 patient (7.14 % developed BVS thrombosis and received a drug-eluting stent. A neointimal layer of the main branch increased during long-term follow-up to 29.23±7.82%, that of the lateral branch – up to 19.2±7.48%. Optical coherence tomography (OCT shows that all strata are fully covered with neointima, the number of strata with malappositions is minimal and the loss of the main branch diameter (16.9±4.9% is insignificant. Conclusion. The use of Absorb bioresorbable vascular scaffolds implanted by means of provisional T-stenting combined with double proximal optimization when treating coronary artery bifurcation lesions is a safe and efficient procedure.Received 2 February 2017. Accepted 10 March 2017.Financing: The study did not have sponsorship.Conflict of interest: The authors declare no conflict of interest.

  20. Effect of simulated pulpal blood flow rate on the rise in pulp chamber temperature during direct fabrication of exothermic provisional restorations.

    Science.gov (United States)

    Farah, R I

    2017-11-01

    To evaluate ex vivo the effect of several simulated pulpal blood flow rates on the change in pulp chamber temperature during direct fabrication of a provisional restoration using a polymethylmethacrylate (PMMA) resin. Fifteen noncarious human premolars were prepared for complete coverage restorations. A curved needle connected to a peristaltic pump simulated the pulp blood flow. Two K-type thermocouples connected to a digital thermometer were placed in the pulp chamber, and the assembly was placed in an incubator at 37 °C. Three provisional crowns were made for each specimen using no water flow (group 1), a 1-mL min -1 flow rate (group 2) and a 0.5-mL/min -1 flow rate (group 3). The pulp chamber temperature was recorded continuously during polymerization until the temperature increase peaked and started to decrease and reached the baseline temperature (37 °C). The temperature increase was measured for the three water flow conditions. Data were analysed statistically using descriptive statistics, repeated measures one-way analysis of variance (anova) with Greenhouse-Geisser correction and Bonferroni tests. The level of significance was set at P temperature. Groups with flow rates at 1 and 0.5 mL min -1 had a significantly lower temperature rise when compared to the group without water flow (P temperature. However, in the presence of simulated pulpal blood flow rates of 1 or 0.5 mL min -1 , the increase in pulp chamber temperature did not exceed the critical threshold (5.6 °C). © 2016 International Endodontic Journal. Published by John Wiley & Sons Ltd.

  1. Losing reduces maximum bite performance in house cricket contests

    National Research Council Canada - National Science Library

    Condon, Catriona; Lailvaux, Simon P; Patek, Sheila

    2016-01-01

    ... of any change in underlying maximum performance capacity. To test the effect of fight experience on performance, we measured the maximum bite force of male Acheta domesticus crickets that were pitted against size...

  2. 5 CFR 550.106 - Annual maximum earnings limitation.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Annual maximum earnings limitation. 550.106 Section 550.106 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Maximum Earnings Limitations § 550.106 Annual maximum...

  3. 5 CFR 550.105 - Biweekly maximum earnings limitation.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Biweekly maximum earnings limitation. 550.105 Section 550.105 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Maximum Earnings Limitations § 550.105 Biweekly maximum...

  4. 20 CFR 617.14 - Maximum amount of TRA.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Maximum amount of TRA. 617.14 Section 617.14... FOR WORKERS UNDER THE TRADE ACT OF 1974 Trade Readjustment Allowances (TRA) § 617.14 Maximum amount of TRA. (a) General rule. Except as provided under paragraph (b) of this section, the maximum amount of...

  5. 16 CFR 1505.7 - Maximum acceptable surface temperatures.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Maximum acceptable surface temperatures... ARTICLES INTENDED FOR USE BY CHILDREN Regulations § 1505.7 Maximum acceptable surface temperatures. The maximum acceptable surface temperatures for electrically operated toys shall be as follows: Surface type...

  6. 7 CFR 3565.210 - Maximum interest rate.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Maximum interest rate. 3565.210 Section 3565.210... AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Loan Requirements § 3565.210 Maximum interest rate. The interest rate for a guaranteed loan must not exceed the maximum allowable rate specified by the Agency in...

  7. Tolerance and acculturation

    Directory of Open Access Journals (Sweden)

    Ursula Småland Goth

    2014-12-01

    study shows a varied pattern of use of GP services among the diverse groups of foreign-born residents. Results suggest that immigrants are more likely to use emergency-room services during the first few years after arrival. Results also indicate that information about the patient-list system does not always reach newly arrived immigrants. Contrary to general understanding, non-visible immigrants (when considering factors such as skin color and clothing diverge the most from the pattern of the majority. Immigrants originating from European countries, such as Sweden and Poland, use the emergency room most frequently. From the qualitative aspects of the study, we have also found that primary health care services are not perceived as equitable.Conclusion: Recently arrived immigrants’ utilization of primary health care services shows an unfavorable pattern. The choice of primary health care service providers is dependent on the individual’s preferences, expectations, experiences and/or actual obstacles. The observed utilization of services provided at emergency rooms is one more reason for monitoring and increasing tolerance and cultural sensitivity in primary health care.

  8. Electron beam energy QA - a note on measurement tolerances.

    Science.gov (United States)

    Meyer, Juergen; Nyflot, Matthew J; Smith, Wade P; Wottoon, Landon S; Young, Lori; Yang, Fei; Kim, Minsun; Hendrickson, Kristi R G; Ford, Eric; Kalet, Alan M; Cao, Ning; Dempsey, Claire; Sandison, George A

    2016-03-08

    Monthly QA is recommended to verify the constancy of high-energy electron beams generated for clinical use by linear accelerators. The tolerances are defined as 2%/2 mm in beam penetration according to AAPM task group report 142. The practical implementation is typically achieved by measuring the ratio of readings at two different depths, preferably near the depth of maximum dose and at the depth corresponding to half the dose maximum. Based on beam commissioning data, we show that the relationship between the ranges of energy ratios for different electron energies is highly nonlinear. We provide a formalism that translates measurement deviations in the reference ratios into change in beam penetration for electron energies for six Elekta (6-18 MeV) and eight Varian (6-22 MeV) electron beams. Experimental checks were conducted for each Elekta energy to compare calculated values with measurements, and it was shown that they are in agreement. For example, for a 6 MeV beam a deviation in the measured ionization ratio of ± 15% might still be acceptable (i.e., be within ± 2 mm), whereas for an 18 MeV beam the corresponding tolerance might be ± 6%. These values strongly depend on the initial ratio chosen. In summary, the relationship between differences of the ionization ratio and the corresponding beam energy are derived. The findings can be translated into acceptable tolerance values for monthly QA of electron beam energies.

  9. Selection of full-sib families of Panicum maximum Jacq under low light conditions

    Directory of Open Access Journals (Sweden)

    Douglas Mochi Victor

    2015-04-01

    Full Text Available The silvopastoral system is a viable technological alternative to extensive cattle grazing, however, for it to be successful, forage grass genotypes adapted to reduced light need to be identified. The objective of this study was to select progenies of Panicum maximum tolerant to low light conditions for use in breeding programs and to study the genetic control and performance of some traits associated with shade tolerance. Six full-sib progenies were evaluated in full sun, 50% and 70% of light reduction in pots and subjected to cuttings. Progeny genotypic values ​​(GV increased with light reduction in relation to plant height (H and specific leaf area (SLA. The traits total dry mass accumulation (DM and leaf dry mass accumulation (LDM had GV higher in 50% shade and intermediate in 70% shade. The GV of tiller number (TIL and root dry mass accumulation (RDM decreased with light reduction. The highest positive correlations were obtained for the traits H and RDM with SLA and DM; the highest negative correlations were between TIL and SLA and RDM, and H and LDM. The progenies showed higher tolerance to 50% light reduction and, among them, two stood out and will be used in breeding programs. It was also found that it is not necessary to evaluate some traits under all light conditions. All traits had high broad sense heritability and high genotypic correlation between progenies in all light intensities. There is genetic difference among the progenies regarding the response to different light intensities, which will allow selection for shade tolerance

  10. Multiperspective analysis of erosion tolerance

    Directory of Open Access Journals (Sweden)

    Sparovek Gerd

    2003-01-01

    Full Text Available Erosion tolerance is the most multidisciplinary field of soil erosion research. Scientists have shown lack in ability to adequately analyze the huge list of variables that influence soil loss tolerance definitions. For these the perspectives of erosion made by farmers, environmentalists, society and politicians have to be considered simultaneously. Partial and biased definitions of erosion tolerance may explain not only the polemic nature of the currently suggested values but also, in part, the nonadoption of the desired levels of erosion control. To move towards a solution, considerable changes would have to occur on how this topic is investigated, especially among scientists, who would have to change methods and strategies and extend the perspective of research out of the boundaries of the physical processes and the frontiers of the academy. A more effective integration and communication with the society and farmers, to learn about their perspective of erosion and a multidisciplinary approach, integrating soil, social, economic and environmental sciences are essential for improved erosion tolerance definitions. In the opinion of the authors, soil erosion research is not moving in this direction and a better understanding of erosion tolerance is not to be expected in the near future.

  11. Public tolerance to defoliation and flower distortion in a public horticulture garden.

    Science.gov (United States)

    Sadof, Clifford S; Sclar, D Casey

    2002-04-01

    Surveys of visitor and grower perception of live potted plant quality were conducted in various locations in a large public display garden. Canna lily, Canna x generalis L.H.Bailey, was used to examine effects of defoliation by Japanese beetle, Popillia japonica Newman, on public perception. Chrysanthemums, Chrysanthemum x morifolium Ramat., were used to identify visitor and grower tolerance to flower distortion caused by western flower thrips, Frankliniella occidentalis (Pergande), on single and multiple flowered plants. On average, the maximum amount of defoliation or flower distortion tolerated by any respondent was low (< or = 10% for canna and < or = 25% for chrysanthemum). The level of acceptable injury was influenced by factors intrinsic to both the respondents and the plants themselves. Tolerance to injury was negatively associated with the risk aversion of the respondents. Visitors were less tolerant of injury on plants they considered for purchase than those that they would view at the garden. Similarly, grower tolerance was lower than that of visitors because producing substandard plants could put their professional reputation at risk. Factors that distracted visitor attention (e.g., presence of flowers and higher levels of background injury) increased their tolerance to plant injury. Visitors tolerated greater levels of flower distortion on multiple flowering chrysanthemum than on those with single flowers. We suggest that tolerance to insect pests can be increased by designing plantings that distract viewers from injured plant parts.

  12. Fault-Tolerant Heat Exchanger

    Science.gov (United States)

    Izenson, Michael G.; Crowley, Christopher J.

    2005-01-01

    A compact, lightweight heat exchanger has been designed to be fault-tolerant in the sense that a single-point leak would not cause mixing of heat-transfer fluids. This particular heat exchanger is intended to be part of the temperature-regulation system for habitable modules of the International Space Station and to function with water and ammonia as the heat-transfer fluids. The basic fault-tolerant design is adaptable to other heat-transfer fluids and heat exchangers for applications in which mixing of heat-transfer fluids would pose toxic, explosive, or other hazards: Examples could include fuel/air heat exchangers for thermal management on aircraft, process heat exchangers in the cryogenic industry, and heat exchangers used in chemical processing. The reason this heat exchanger can tolerate a single-point leak is that the heat-transfer fluids are everywhere separated by a vented volume and at least two seals. The combination of fault tolerance, compactness, and light weight is implemented in a unique heat-exchanger core configuration: Each fluid passage is entirely surrounded by a vented region bridged by solid structures through which heat is conducted between the fluids. Precise, proprietary fabrication techniques make it possible to manufacture the vented regions and heat-conducting structures with very small dimensions to obtain a very large coefficient of heat transfer between the two fluids. A large heat-transfer coefficient favors compact design by making it possible to use a relatively small core for a given heat-transfer rate. Calculations and experiments have shown that in most respects, the fault-tolerant heat exchanger can be expected to equal or exceed the performance of the non-fault-tolerant heat exchanger that it is intended to supplant (see table). The only significant disadvantages are a slight weight penalty and a small decrease in the mass-specific heat transfer.

  13. What is Fault Tolerant Control

    DEFF Research Database (Denmark)

    Blanke, Mogens; Frei, C. W.; Kraus, K.

    2000-01-01

    availability and reduce the risk of safety hazards. Its aim is to prevent that simple faults develop into serious failure. Fault-tolerant control merges several disciplines to achieve this goal, including on-line fault diagnosis, automatic condition assessment and calculation of remedial actions when a fault......Faults in automated processes will often cause undesired reactions and shut-down of a controlled plant, and the consequences could be damage to the plant, to personnel or the environment. Fault-tolerant control is the synonym for a set of recent techniques that were developed to increase plant...

  14. Tolerating extremism : to what extent should intolerance be tolerated?

    NARCIS (Netherlands)

    Guiora, Amos Neuser

    2013-01-01

    In discussing extremism, the key questions are: to whom is a duty owed and what are the limits of intolerance that are to be tolerated? Answering these questions requires examining limits and rights; analyzing them in the context of extremism is the ‘core’ of this book. While freedom of speech and

  15. SU-E-T-444: Gravity Effect On Maximum Leaf Speed in Dynamic IMRT Treatments

    Energy Technology Data Exchange (ETDEWEB)

    Olasolo, J; Pellejero, S; Gracia, M; Gallardo, N; Martin, ML; Lozares, S; Maneru, F; Bragado, L; Miquelez, S [Complejo Hospitalario de Navarra, Pamplona (Spain); Artacho, JM [Universidad de Zaragoza, Zaragoza (Spain)

    2015-06-15

    Purpose: A leaf sequencing algorithm has been recently developed in our department. Our purpose is to utilize this algorithm to reduce treatment time by studying the feasibility of using several maximum leaf speeds depending on gantry angle and leaf thickness (0.5 or 1 cm at isocenter). To do so, the gravity effect on MLC performance has been examined by means of analysing the dynalog files. Methods: Leaf position errors has been ascertained according to gantry angle and leaf speed in MLC Millenium120 (Varian). In order to do this, the following test has been designed: all leaves move in synchrony, with same speed and 1 cm gap between opposite leaves. This test is implemented for 18 different speeds: 0.25-0.5-0.75-1-1.25-1.5-1.75-2-2.1-2.2-2.3-2.4-2.5-2.6-2.7-2.8-2.9-3.0 cm/s and 8 gantry angles: 0-45-90-135-180-225-270-315. Collimator angle is 2 degrees in all cases since it is the most usual one in IMRT treatments in our department. Dynamic tolerance is 2 mm. Dynalogs files of 10 repetitions of the test are analysed with a Mathlab in-house developed software and RMS error and 95th percentiles are calculated. Varian recommends 2.5 cm/s as the maximum leaf speed for its segmentation algorithm. In our case, we accept this speed in the most restrictive situation: gantry angle 270 and 1 cm leaf thickness. Maximum speeds for the rest of the cases are calculated by keeping the difference between 95th percentile and dynamic tolerance. In this way, beam hold-off probability does not increase. Results: Maximum speeds every 45 degrees of gantry rotation have been calculated for both leaf thickness. These results are 2.9-2.9-2.9-2.9-2.7-2.6-2.6-2.7 cm/s for 0.5 cm leaf thickness and 2.7-2.7-2.7-2.7-2.6-2.5-2.5-2.6 cm/s for 1 cm leaf thickness. Conclusion: Gravity effect on MLC positioning has been studied. Maximum leaf speed according to leaf thickness and gantry angle have been calculated which reduces treatment time.

  16. Maximum physical capacity testing in cancer patients undergoing chemotherapy

    DEFF Research Database (Denmark)

    Knutsen, L.; Quist, M; Midtgaard, J

    2006-01-01

    BACKGROUND: Over the past few years there has been a growing interest in the field of physical exercise in rehabilitation of cancer patients, leading to requirements for objective maximum physical capacity measurement (maximum oxygen uptake (VO(2max)) and one-repetition maximum (1RM)) to determine...... dose-response levels in different cancer diagnoses. AIM: To explore the patients' experiences of maximum physical capacity testing while concurrently undergoing chemotherapy and participating in a 6-week, 9 h weekly multidimensional exercise program. DESIGN AND METHOD: Prospective, exploratory study...... in performing maximum physical capacity tests as these motivated them through self-perceived competitiveness and set a standard that served to encourage peak performance. CONCLUSION: The positive attitudes in this sample towards maximum physical capacity open the possibility of introducing physical testing...

  17. Maximum expiration activates the abdominal muscles during side bridge exercise.

    Science.gov (United States)

    Ishida, Hiroshi; Watanabe, Susumu

    2014-01-01

    Recent studies have indicated that maximum expiration could be a useful way of performing challenging exercises that include coactivation of the deep and superficial abdominal muscles. However, little is known about the effect of maximum expiration on the activity of the abdominal muscles during lumbar stabilizing exercise. The purpose of our study was to quantify changes in the activities of the abdominal muscles during side bridge exercise in combination with maximum expiration. Experimental laboratory study. The activities of the rectus abdominis (RA), external oblique (EO), and internal oblique (IO) muscles were measured using electromyography in 12 healthy men performing 3 tasks: holding the breath after maximum expiration in the prone position, holding the breath after resting expiration during side bridge exercise, and holding the breath after maximum expiration during side bridge exercise. Significant increases in the activities of the abdominal muscles (RA, EO, and IO) occurred with maximum expiration when compared with resting expiration during side bridge exercise (P core training.

  18. 77 FR 65831 - Polymers; exemptions from the requirement of a tolerance.

    Science.gov (United States)

    2012-10-31

    ... AGENCY 40 CFR Part 180 -( -Nonylphenyl)poly(oxypropylene) Block Polymer With Poly(oxyethylene); Tolerance...) block polymer with poly(oxyethylene); when used as an inert ingredient in a pesticide chemical... establish a maximum permissible level for residues of - ( -Nonylphenyl)poly(oxypropylene) block polymer with...

  19. Maximum Relative Entropy of Coherence: An Operational Coherence Measure

    Science.gov (United States)

    Bu, Kaifeng; Singh, Uttam; Fei, Shao-Ming; Pati, Arun Kumar; Wu, Junde

    2017-10-01

    The operational characterization of quantum coherence is the cornerstone in the development of the resource theory of coherence. We introduce a new coherence quantifier based on maximum relative entropy. We prove that the maximum relative entropy of coherence is directly related to the maximum overlap with maximally coherent states under a particular class of operations, which provides an operational interpretation of the maximum relative entropy of coherence. Moreover, we show that, for any coherent state, there are examples of subchannel discrimination problems such that this coherent state allows for a higher probability of successfully discriminating subchannels than that of all incoherent states. This advantage of coherent states in subchannel discrimination can be exactly characterized by the maximum relative entropy of coherence. By introducing a suitable smooth maximum relative entropy of coherence, we prove that the smooth maximum relative entropy of coherence provides a lower bound of one-shot coherence cost, and the maximum relative entropy of coherence is equivalent to the relative entropy of coherence in the asymptotic limit. Similar to the maximum relative entropy of coherence, the minimum relative entropy of coherence has also been investigated. We show that the minimum relative entropy of coherence provides an upper bound of one-shot coherence distillation, and in the asymptotic limit the minimum relative entropy of coherence is equivalent to the relative entropy of coherence.

  20. Asymptotic Behavior of the Maximum Entropy Routing in Computer Networks

    Directory of Open Access Journals (Sweden)

    Milan Tuba

    2013-01-01

    Full Text Available Maximum entropy method has been successfully used for underdetermined systems. Network design problem, with routing and topology subproblems, is an underdetermined system and a good candidate for maximum entropy method application. Wireless ad-hoc networks with rapidly changing topology and link quality, where the speed of recalculation is of crucial importance, have been recently successfully investigated by maximum entropy method application. In this paper we prove a theorem that establishes asymptotic properties of the maximum entropy routing solution. This result, besides being theoretically interesting, can be used to direct initial approximation for iterative optimization algorithms and to speed up their convergence.

  1. [A pilot clinical study of immediate provisionalization with a chairside computer aided design and computer aided manufacture monolithic crown for single tooth immediate implant placement].

    Science.gov (United States)

    Tian, J H; Di, P; Lin, Y; Zhang, Y; Wei, D H; Cui, H Y

    2017-01-09

    Objective: To evaluate the primary clinical outcomes of immediate provisionalization with a monolithic crown utilizing a novel chairside computer aided design and computer aided manufacture (CAD/CAM) workflow for single tooth immediate implant placement. Methods: This pilot study was a prospective within-subjects design. Thirteen consecutive patients were included and diagnosed with untreatable single incisor or premolar with fine general and local anatomical conditions. The trial was conducted at Department of Implantology, Peking University School and Hospital of Stomatology, Beijing, between January 2016 and June 2016. The teeth were extracted atraumatically and implants were immediately placed in the fresh sockets. Two screw-retained interim crowns were fabricated for the same site utilizing different workflows, a monolithic lithium disilicate (LS2) crown produced by CEREC (Sirona, Germany) chairside CAD/CAM system (CER group) and a manually fabricated resin crown utilizing conventional workflow (CONV group) respectively. The patients were blinded to the group allocation of the two interim crowns. After the clinical try-in for both crowns in a randomized sequence, the patients' level of satisfaction was assessed with a virtual analogue scale (VAS) questionnaire. The restorations chosen by patients themselves were seated in the implants by one experienced prosthodontist. The accuracy, aesthetic effect and clinical time consumption of both groups were compared. Statistical analyses were performed with the Wilcoxon signed rank test. Results: All patients were treated with atraumatic tooth extraction, immediate implant placement using flapless surgery and immediate provisionalization in a single visit. The interim crowns of both groups could be fitted with or without slight adjustments. For each patient, the interim crown of CER group was chosen to be seated with a relatively higher VAS result. The white esthetic score (WES) results demonstrated no statistically

  2. Reinforcement of acrylic resins for provisional fixed restorations. Part III: effects of addition of titania and zirconia mixtures on some mechanical and physical properties.

    Science.gov (United States)

    Panyayong, W; Oshida, Y; Andres, C J; Barco, T M; Brown, D T; Hovijitra, S

    2002-01-01

    Acrylic resins have been used in many different applications in dentistry, especially in the fabrication of provisional fixed partial dentures. Ideally, a provisional crown and bridge material should be easy to handle and should protect teeth against physical, chemical, and thermal injuries. Some of the problems associated with this use are related to the material's poor mechanical properties. It has been demonstrated that acrylic resin can be strengthened through the addition of structural component of different size distributed in the acrylic matrix, thus forming a composite structure. The purpose of this study was to investigate the addition effects of mixtures of titania (titanium dioxide, TiO(2)) powder and zirconia (zirconium dioxide, ZrO(2)) powder being incorporated with pre-polymerized beads mixed in monomer liquid, on some mechanical and physical properties of PMMA resin. The pre-polymerized powder poly(methyl methacrylate) resin was admixed with titania and zirconia powder. A mixing ratio was controlled by volume % of 0, 1.0, 2.0, and 3.0 (samples with 0 v/o served as control groups). For using mixture of titania and zirconia, total amount of the mixture was controlled by volume % of 1.0, 2.0, and 3.0, in which titania and zirconia were mixed at the ratio 1 :1, 1 :2 and 2 :1. Prior to mechanical tests, all rectangular-shaped samples (25 mm x 2 mm x 5 mm) were stored in 37 degrees C distilled water for 7 days after polishing all six sides of samples. Samples were then subjected to the three-point bending flexion test to evaluate the bending strength as well as the modulus of elasticity. Weight gain and exothermic reaction survey were investigated as well. All data were collected and analyzed with one-way analysis of variance (ANOVA) and Sidak method (p=0.05). It was found that the addition of particles generally decreased the water absorbed by the composite system. Only 1 percent by volume concentration of 1 :1 ratio and 2 percent by volume concentration

  3. "Zero Tolerance" for Free Speech.

    Science.gov (United States)

    Hils, Lynda

    2001-01-01

    Argues that school policies of "zero tolerance" of threatening speech may violate a student's First Amendment right to freedom of expression if speech is less than a "true threat." Suggests a two-step analysis to determine if student speech is a "true threat." (PKP)

  4. Fault Tolerance Using Group Communication

    NARCIS (Netherlands)

    Kaashoek, M.F.; Tanenbaum, A.S.

    We propose group communication as an efficient mechanism to support fault tolerance. Our approach is based on an efficient reliable broadcast protocol that requires on average only two messages per broadcast. To illustrate our approach we will describe how the task bag model can be made

  5. New fault tolerant matrix converter

    Energy Technology Data Exchange (ETDEWEB)

    Ibarra, Edorta; Andreu, Jon; Kortabarria, Inigo; Ormaetxea, Enekoitz; Alegria, Inigo Martinez de; Martin, Jose Luis [Department of Electronics and Telecommunications, University of the Basque Country, Alameda de Urquijo s/n, E-48013 Bilbao (Spain); Ibanez, Pedro [TECNALIA, Energy Unit, Parque Tecnologico de Zamudio, E-48170 Bizkaia (Spain)

    2011-02-15

    The matrix converter (MC) presents a promising topology that will have to overcome certain barriers (protection systems, durability, the development of converters for real applications, etc.) in order to gain a foothold in the industry. In some applications, where continuous operation must be insured in the case of a system failure, improved reliability of the converter is of particular importance. In this sense, this article focuses on the study of a fault tolerant MC. The fault tolerance of a converter is characterized by its total or partial response in the case of a breakage of any of its components. Taking into consideration that virtually no work has been done on fault tolerant MCs, this paper describes the most important studies in this area. Moreover, a new method is proposed for detecting the breakage of MC semiconductors. Likewise, a new variation of SVM modulation with failure tolerance capacity is presented. This guarantees the continuous operation of the converter and the pseudo-optimum control of a PMSM. This paper also proposes a novel MC topology, which allows the flexible reconfiguration of this converter, when one or several of its semiconductors are damaged. In this way, the MC can continue operating at 100% of its performance without having to double its resources. In this way, it can be said that the solution described in this article represents a step forward towards the development of reliable matrix converters for real applications. (author)

  6. When Should Sects be Tolerated?

    DEFF Research Database (Denmark)

    Hvithamar, Annika

    2009-01-01

    Jehovas vidners kontroverser med majoritetssamfundet gør dem til et godt test-case for tolerance. I artiklen bruges udviklingen af bevægelsens syn på blodstransfusioner til at diskutere, hvordan institutionaliseringen af en minoritetsbevægelse får kontroversernes styrke til at mindskes, men også ...

  7. ORAL GLUCOSE TOLERANCE TEST REVISITED

    African Journals Online (AJOL)

    0 Abnormal previous glucose result of either impaired fasting plasma glucose ... Population studies for epidemiological data are known indications for oral ... Table I : Factors other than diabetes that may influence oral glucose tolerance test 1. Patient's preparation. 0 Duration of fast. Prior carbohydrate intake. Medications.

  8. Fault tolerance in "multiprocessor systems

    Indian Academy of Sciences (India)

    puter architecture; [multiprocessor systems; reconfiguration; system- level diagnosis; VLSI processor arrays. 1. Introduction. Fault-tolerant computing can be defined as the ability to execute specified algorithms correctly inspite of the presence of faults. The complexity of supersystems and the increasing use of such computer ...

  9. Utility and tolerance of stress testing in geriatric patients.

    Science.gov (United States)

    Aparici, M; Peteiro, J; Fernandez de Almeida, C A; Hidalgo, R; Cabañero, J; Barba, J

    1990-10-01

    To determine the sensitivity and specificity of stress testing in geriatric patients and to estimate the tolerance of these patients to exercise. A prospective study done in two populations with different ages. Cardiologists and a stress testing laboratory. Persons with ages above and under 65 years who were admitted in our center and submitted to stress testing and coronary angiography for suspicion of ischemic heart disease. All stress tests were performed on a Siemens Elama cicloergometer model 380-B adapted to a Hewlett Packard 1517 A ECG recorder. Our protocol started with an initial work load of 30 Watts with increments of other 30 Watts every three minutes. A 12 lead ECG was registered at rest, at maximum effort and in the recovery phase (approx. eight minutes after maximum effort). Three leads ECG's (V2, aVF, V5) were registered every three minutes. Stress finishing criteria were: symptom's limited, fatigue and maximum heart rate (220-age). Blood pressure was also controlled every three minutes during exercise and every two minutes during the recovery phase. Coronary angiographies were performed on a Siemens Cardoskop U (cine) using the Judkins technique. Left anterior oblique, right anterior oblique and postero anterior projections were used in all the procedures. Stress testing presents high sensitivity and low specificity in geriatric patients. A good tolerance to exercise was observed in this group of patients. A similar sensitivity was observed in the stress tests performed by patients with ages above and under 65 years. Sensitivity seems to be related to the severity of the coronary lesion. On the other hand stress testing presented a lower specificity in the geriatric patient. Finally, good tolerance to exercise was observed in patients older than 65 years.

  10. MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

    Science.gov (United States)

    Tamura, Koichiro; Peterson, Daniel; Peterson, Nicholas; Stecher, Glen; Nei, Masatoshi; Kumar, Sudhir

    2011-01-01

    Comparative analysis of molecular sequence data is essential for reconstructing the evolutionary histories of species and inferring the nature and extent of selective forces shaping the evolution of genes and species. Here, we announce the release of Molecular Evolutionary Genetics Analysis version 5 (MEGA5), which is a user-friendly software for mining online databases, building sequence alignments and phylogenetic trees, and using methods of evolutionary bioinformatics in basic biology, biomedicine, and evolution. The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models (nucleotide or amino acid), inferring ancestral states and sequences (along with probabilities), and estimating evolutionary rates site-by-site. In computer simulation analyses, ML tree inference algorithms in MEGA5 compared favorably with other software packages in terms of computational efficiency and the accuracy of the estimates of phylogenetic trees, substitution parameters, and rate variation among sites. The MEGA user interface has now been enhanced to be activity driven to make it easier for the use of both beginners and experienced scientists. This version of MEGA is intended for the Windows platform, and it has been configured for effective use on Mac OS X and Linux desktops. It is available free of charge from http://www.megasoftware.net. PMID:21546353

  11. A 5 Gb/s Radiation Tolerant Laser Driver

    CERN Document Server

    Amaral, L; Da Silva, S; Mazza, G; Meroli, S; Moreira, P; Rivetti, A; Troska, J; Wyllie, K

    2009-01-01

    A laser driver for data transmission at 5 Gb/s has been developed as a part of the Giga Bit Transceiver (GBT) project. The Giga Bit Laser Driver (GBLD) targets High Energy Physics (HEP) applications for which radiation tolerance is mandatory. The GBLD ASIC can drive both VCSELs and some types of edge emitting lasers. It is essentially composed of two drivers capable of sinking up to 12 mA each from the load at a maximum data rate of 5 Gb/s, and of a current sink for the laser bias current. The laser driver include also pre-emphasis and duty cycle control capabilities.

  12. Morfogênese de cultivares de Panicum maximum jacq. Morphogenesis of Panicum maximum jacq. cultivars

    Directory of Open Access Journals (Sweden)

    Carlos Augusto Miranda Gomide

    2000-04-01

    Full Text Available Quatro cultivares de Panicum maximum, Mombaça, Tanzânia, Vencedor e Centenário, foram cultivados em vasos, sob cobertura plástica transparente, para estudo da dinâmica do crescimento de folhas e perfilhos, em dois tipos de perfilho, o principal e o primário, e dois crescimentos, o de estabelecimento, logo após a emergência das plântulas, e o de rebrota, após corte, a 8 cm do solo, aos 21 dias. Os tratamentos foram estudados, em arranjo fatorial 4 x 2 x 2, segundo delineamento de blocos completamente casualizados com quatro repetições. O comprimento da lâmina foliar cresceu com o nível de inserção até a folha de número 9 ou 10, tornando-se menor nas folhas subseqüentes. O perfilhamento teve início na segunda semana de idade e se estendeu até 22 dias de idade, quando o número de perfilhos por planta se estabilizou. O cultivar Tanzânia apresentou maior número de perfilhos por planta (15, enquanto em Mombaça e Vencedor foram observados apenas 10 perfilhos. Maiores taxas de aparecimento e alongamento de folhas foram observadas durante o crescimento de estabelecimento. Em ambos os crescimentos, o cultivar Vencedor exibiu a maior taxa de aparecimento de folhas. O número médio de folhas verdes por perfilho estabilizou-se em 6,5 no cultivar Vencedor e 3,5 nos demais cultivares, no crescimento de rebrota, em que a vida útil das folhas foi de 29 dias para o cultivar Centenário e 36 dias para os demais.Four cultivars of Panicum maximum: Mombaça, Tanzânia, Centenário and Vencedor were grown in pots, under a transparent plastic cover, to evaluate the dynamic of leaf and tillers growth. Two growths, the establishment and the aftermath, after clipping at the age of 21 days, and two types of tiller, main and primary tillers, were studied. A completely randomized design with four replicates was used to compare the treatments resulting from a 4 x 2 x 2 factorial arrangement. The leaf blade length increased with insertion level until

  13. A three-tier phenotyping approach for hunting QTLs related to heat tolerance in bread wheat

    DEFF Research Database (Denmark)

    Sharma, Dew Kumari; Rosenqvist, Eva; Ottosen, Carl-Otto

    - with a top-to-bottom (forward) approach: Tier 1: Phenotyping: As a starting point,the quantification of heat tolerance was done by the chlorophyll fluorescence parameter, Fv/Fm, as a measure of maximum quantum efficiency of PSII photochemistry after heat stress treatment (40°C for 72h). This way......, stomatal conductance and transpiration rate, suggesting that the tolerant cultivars had better evaporative cooling and stay green characteristics under heat stress. Further, cultivar Fv/Fm and dry matter content also showed a significant positive correlation. Tier 3: Linking phenotypic differences to QTLs......, wheat is sensitive to heat stress, particularly at the reproductive phase. Heat tolerance is a complex trait. In the present study, a combined approach of physiological phenotyping and quantitative genetics was used to dissect the complex nature of heat tolerance into photosynthesis related traits...

  14. Modelling highly variable daily maximum water temperatures in a ...

    African Journals Online (AJOL)

    ... hourly water temperatures were used to calculate daily maximum water temperatures for nine sites within the Sabie-Sand River system, Mpumalanga Province, South Africa. A suite of statistical models for simulating daily maximum water temperatures, of differing complexity and using inputs of air temperature, flow rates, ...

  15. 24 CFR 242.7 - Maximum mortgage amounts.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Maximum mortgage amounts. 242.7... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES MORTGAGE INSURANCE FOR HOSPITALS General Eligibility Requirements § 242.7 Maximum mortgage amounts. The...

  16. 50 CFR 648.20 - Maximum optimum yield (OYs).

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Maximum optimum yield (OYs). 648.20 Section 648.20 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... Measures for the Atlantic Mackerel, Squid, and Butterfish Fisheries § 648.20 Maximum optimum yield (OYs...

  17. Efficiency at Maximum Power of Interacting Molecular Machines

    DEFF Research Database (Denmark)

    Golubeva, Natalia; Imparato, Alberto

    2012-01-01

    We investigate the efficiency of systems of molecular motors operating at maximum power. We consider two models of kinesin motors on a microtubule: for both the simplified and the detailed model, we find that the many-body exclusion effect enhances the efficiency at maximum power of the many- motor...

  18. High latitude hydrological changes during the Eocene Thermal Maximum 2

    NARCIS (Netherlands)

    Krishnan, Srinath; Pagani, Mark; Huber, Matthew; Sluijs, Appy

    2014-01-01

    The Eocene hyperthermals, including the Paleocene-Eocene Thermal Maximum (PETM) and Eocene Thermal Maximum 2 (ETM2), represent extreme global warming events ~56 and 54 million years ago associated with rapid increases in atmospheric greenhouse gas concentrations. An initial study on PETM

  19. 7 CFR 3565.208 - Maximum loan term.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Maximum loan term. 3565.208 Section 3565.208... AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Loan Requirements § 3565.208 Maximum loan term. (a) Statutory term limit. The lender may set the term of the loan, but in no instance may the term of a...

  20. 47 CFR 95.639 - Maximum transmitter power.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Maximum transmitter power. 95.639 Section 95.639 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES... (ERP). (e) The maximum transmitter output power authorized for LPRS stations is 100 mW. (f) In the Med...

  1. Maximum and Minimum Galactic Background Radiation at 45 MHz

    Science.gov (United States)

    May, J.; Alvarez, H.; Aparici, J.; Reyes, F.; Olmos, F.

    1985-03-01

    The maximum and the minimum of the galactic background radiation have been measured at 45 MHz with a 528 dipole array at the Maipu Radio Astronomy Observatory. Antenna temperatures of 89000 K and 3050 K have been obtained for the maximum and the minimum respectively.

  2. 20 CFR 615.7 - Extended Benefits; maximum amount.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Extended Benefits; maximum amount. 615.7 Section 615.7 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR EXTENDED BENEFITS IN THE FEDERAL-STATE UNEMPLOYMENT COMPENSATION PROGRAM § 615.7 Extended Benefits; maximum amount...

  3. 30 CFR 57.5039 - Maximum permissible concentration.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Maximum permissible concentration. 57.5039... Maximum permissible concentration. Except as provided by standard § 57.5005, persons shall not be exposed to air containing concentrations of radon daughters exceeding 1.0 WL in active workings. ...

  4. 32 CFR 842.35 - Depreciation and maximum allowances.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Depreciation and maximum allowances. 842.35... LITIGATION ADMINISTRATIVE CLAIMS Personnel Claims (31 U.S.C. 3701, 3721) § 842.35 Depreciation and maximum allowances. The military services have jointly established the “Allowance List-Depreciation Guide” to...

  5. Nonparametric estimation of the maximum of conditional hazard ...

    African Journals Online (AJOL)

    The maximum of the conditional hazard function is a parameter of great importance in statistics, in particular in seismicity studies, because it constitutes the maximum risk of occurrence of an earthquake in a given interval of time. Using the kernel nonparametric estimates based on convolution kernel techniques of the rst ...

  6. correlation between maximum dry density and cohesion of ...

    African Journals Online (AJOL)

    HOD

    Due to the ever increasing cost of laboratory equipment to determine soil parameters such as cohesion and maximum dry density and the enormous time and energy dissipated in such experiment, this research work was attempted in order to investigate the possible correlation between cohesion and maximum dry density.

  7. 42 CFR 447.54 - Maximum allowable and nominal charges.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Maximum allowable and nominal charges. 447.54 Section 447.54 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Deductible, Coinsurance, Co-Payment Or Similar Cost-Sharing Charge § 447.54 Maximum allowable and nominal...

  8. Plant salt tolerance: adaptations in halophytes

    National Research Council Canada - National Science Library

    Flowers, Timothy J; Colmer, Timothy D

    2015-01-01

    ..., and to develop salt-tolerant crops. In this Preface to a Special Issue on halophytes and saline adaptations, the evolution of salt tolerance in halophytes, their life-history traits and progress in understanding...

  9. Urbanism, Migration, and Tolerance: A Reassessment.

    Science.gov (United States)

    Wilson, Thomas C.

    1991-01-01

    Urbanism's impact on the personality may be stronger than previously thought. Finds that urban residence has a strong positive effect on tolerance. Migration also promotes tolerance, regardless of the size of the destination community. (DM)

  10. Drought and submergence tolerance in plants

    Science.gov (United States)

    Du, Hewei; Zhou, Yufan; Oksenberg, Nir; Ronald, Pamela

    2017-11-14

    The invention provides methods of genetically modified plants to increase tolerance to drought and/or submergence. The invention additionally provides plants having increased drought and/or submergence tolerance engineered using such methods.

  11. Physiological determinants of human acute hypoxia tolerance.

    Science.gov (United States)

    2013-11-01

    AbstractIntroduction. We investigated possible physiological determinants of variability in hypoxia tolerance in subjects given a 5-minute normobaric exposure to 25,000 ft equivalent. Physiological tolerance to hypoxia was defined as the magnitude of...

  12. Internal contamination of a 2-component implant system after occlusal loading and provisionally luted reconstruction with or without a washer device.

    Science.gov (United States)

    Rimondini, L; Marin, C; Brunella, F; Fini, M

    2001-12-01

    Microbial internal contamination of oral implants has been suggested as being responsible for inflammatory infiltration of peri-implant tissues at the fixture-abutment interface of 2-stage and 2-component implant systems; it is also considered as a potential source of pathogens. The present in vivo study evaluated contamination of the inner abutment-implant retaining screw, after occlusal loading and provisionally-luted reconstruction with or without a washer device. Eight 2-component oral implants sealed with an o-ring silicon washer device and 9 without a seal were placed in 7 patients with high oral hygiene standards. Two months after prosthetic reconstruction, crowns and internal screws were removed, and organic and inorganic screw contamination was examined by scanning electron microscopy and energy dispersive x-ray spectroscopy (EDS) analysis. An amorphous and crystalline contamination, suggestive of calcium and phosphate compounds, was seen on all screw surfaces. Microbial contamination was more frequently observed in the unsealed group. No differences in bacterial morphotypes were observed between the sealed and unsealed implants. Cocci were the most representative morphotypes, while rods were seldom seen. In clinical situations, leakage occurs at the implant-abutment interface, although bacterial contamination is limited in patients with high oral hygiene standards. Contamination may be reduced by using a washer device.

  13. A network approach for provisional assay recognition of a Hendra virus antibody ELISA: test validation with low sample numbers from infected horses.

    Science.gov (United States)

    Colling, Axel; Lunt, Ross; Bergfeld, Jemma; McNabb, Leanne; Halpin, Kim; Juzva, Susan; Newberry, Kim; Morrissy, Chris; Loomes, Cameron; Warner, Simone; Diallo, Ibrahim; Kirkland, Peter; Broder, Christopher C; Carlile, Gemma; Loh, Mai Hlaing; Waugh, Caryll; Wright, Lynda; Watson, James; Eagles, Debbie; Zuelke, Kurt; McCullough, Sam; Daniels, Peter

    2018-02-01

    Obtaining statistically sound numbers of sera from Hendra virus (HeV)-infected horses is problematic because affected individuals usually die or are euthanized before developing a serum antibody response. As a consequence, test validation becomes a challenge. Our approach is an extension of OIE principles for provisional recognition and included 7 validation panels tested across multiple laboratories that provided estimates for test performance characteristics. At a 0.4 S/P cutoff, 16 of 19 sera from HeV-infected horses gave positive results in the HeV soluble G, indirect ELISA (HeVsG iELISA; DSe 84.2% [95% CI: 60.4-96.6%]); 463 of 477 non-infected horse sera tested negative (DSp 97.1% [95% CI: 95.1-98.4%]). The HeVsG iELISA eliminated almost all false-positive results from the previously used HeV iELISA, with marginally decreased relative sensitivity. Assay robustness was evaluated in inter-laboratory and proficiency testing panels. The HeVsG iELISA is considered to be fit for purpose for serosurveillance and international movement of horses when virus neutralization is used for follow-up testing of positive or inconclusive serum samples.

  14. Immediate loading of maxillary prostheses using flapless surgery, implant placement in predetermined positions, and prefabricated provisional restorations. Part 2: a retrospective 10-year clinical study.

    Science.gov (United States)

    Rocci, Antonio; Rocci, Marta; Scoccia, Andrea; Martignoni, Massimiliano; Gottlow, Jan; Sennerby, Lars

    2012-01-01

    Immediate loading has become a widely reported practice in implant dentistry. The aim of this study is to report on the 10-year clinical and radiographic outcomes of an immediate-loading treatment protocol that included flapless surgery. Forty-six patients were treated with 97 immediately loaded Mk IV implants (Nobel Biocare) with machined surface in the maxilla. Presurgically, a three-dimensional model of each patient's soft tissue and underlying alveolar bone anatomy was created and a surgical template was fabricated. A circular mucotome was used to punch out a 5-mm hole in the mucosa to avoid flap elevation. Control examinations were performed on the day of surgery and at 1, 2, 3, 6, 8, and 10 years after surgery. All prepared implant sites had intact buccal and lingual bone walls. The prefabricated provisional restorations showed excellent fit. Nine implants failed within 8 weeks of loading, resulting in a cumulative survival rate of 91% after 10 years of loading. The survival rates were 94% for implants supporting partial prostheses and 81% for implants supporting single restorations. Average marginal bone resorption was 1 mm during the first year, 0.4 mm during the second year, and 0.1 mm during the third year and after 10 years. The unchanged survival rate and the low average bone loss after 10 years confirm the feasibility of an immediate loading treatment protocol in the maxilla that included flapless surgery.

  15. Effects of connective tissue grafting on the facial gingival level following single immediate implant placement and provisionalization in the esthetic zone: a 1-year randomized controlled prospective study.

    Science.gov (United States)

    Yoshino, Shuji; Kan, Joseph Y K; Rungcharassaeng, Kitichai; Roe, Phillip; Lozada, Jaime L

    2014-01-01

    This 1-year randomized controlled prospective study evaluated the implant success rate and peri-implant tissue response following single immediate implant placement and provisionalization (IIPP) with and without subepithelial connective tissue graft (SCTG) in the esthetic zone. Implants were placed either IIPP with SCTG (test group) or IIPP without SCTG (control group). The implants were evaluated both clinically and radiographically before surgery, immediately after implant placement, and 3, 6, and 12 months after implant placement. Data were analyzed using Friedman, Wilcoxon signed-rank, and Mann-Whitney U tests at the significance level of α = .05. Twenty implants (10 test, 10 control) were placed in 20 patients (7 men, 13 women) between the ages of 27 and 87 (mean age, 52.6 years). At 1 year, all implants remained osseointegrated, with overall mean marginal bone changes of -0.01 mm and -0.14 mm for the test and control groups, respectively. Mean facial gingival level change was significantly more pronounced in the control group (-0.70 mm) than in the test group (-0.25 mm). The modified Plaque Index scores showed that patients were able to maintain a good level of hygiene throughout the study. At 1 year, the Papilla Index indicated that more than 50% papilla fill was observed in 75% of the test sites and 80% of the control sites. Within the limitations of this study, SCTG was shown to be beneficial in maintaining facial gingival level when performed in conjunction with IIPP procedures.

  16. Maximum Principles for Discrete and Semidiscrete Reaction-Diffusion Equation

    Directory of Open Access Journals (Sweden)

    Petr Stehlík

    2015-01-01

    Full Text Available We study reaction-diffusion equations with a general reaction function f on one-dimensional lattices with continuous or discrete time ux′  (or  Δtux=k(ux-1-2ux+ux+1+f(ux, x∈Z. We prove weak and strong maximum and minimum principles for corresponding initial-boundary value problems. Whereas the maximum principles in the semidiscrete case (continuous time exhibit similar features to those of fully continuous reaction-diffusion model, in the discrete case the weak maximum principle holds for a smaller class of functions and the strong maximum principle is valid in a weaker sense. We describe in detail how the validity of maximum principles depends on the nonlinearity and the time step. We illustrate our results on the Nagumo equation with the bistable nonlinearity.

  17. Disposition and tolerance of suxibuzone in horses.

    Science.gov (United States)

    Jaraiz, M V; Rodriguez, C; San Andres, M D; Gonzalez, F; San Andres, M I

    1999-09-01

    Suxibuzone (SBZ), a nonsteroidal anti-inflammatory drug, was administered to 6 horses at a dose rate of 7.5 mg/kg bwt by intravenous (i.v.) route. Plasma and synovial fluid concentrations of suxibuzone and its main active metabolites, phenylbutazone (PBZ) and oxyphenbutazone (OPBZ), were measured simultaneously by a sensitive and specific high-performance liquid chromatographic method. The pharmacokinetic parameters were determined by noncompartmental analysis. Plasma SBZ concentrations rapidly decreased and were not detectable beyond 20 min after treatment. The parent drug was not detected in any synovial fluid samples. Average maximum plasma concentrations of PBZ (16.43 microg/ml) and OPBZ (2.37 microg/ml) were attained at 0.76 and 7.17 h, respectively. The mean residence time (MRT) of PBZ was 6.96 h in plasma. Oxyphenbutazone plasma concentrations were below those reached by phenylbutazone during the first 12 h after suxibuzone administration, even though its values were detectable for at least 24 h (MRT = 10.65 h). Plasma concentrations of PBZ and OPBZ exceeding EC50 and IC50 of TXB2 and PGE2 were reached by at least 12 h. Synovial fluid concentrations of PBZ and OPBZ were 2.87+/-0.37 microg/ml and 0.97+/-0.08 microg/ml at 9 h after suxibuzone administration and exceeded IC50 of PGE2 for at least this time. In the present study, suxibuzone was well tolerated following i.v. injection.

  18. Defect Tolerance in Methylammonium Lead Triiodide Perovskite

    Energy Technology Data Exchange (ETDEWEB)

    Steirer, K. Xerxes; Schulz, Philip; Teeter, Glenn; Stevanovic, Vladan; Yang, Mengjin; Zhu, Kai; Berry, Joseph J.

    2016-08-12

    Photovoltaic applications of perovskite semiconductor material systems have generated considerable interest in part because of predictions that primary defect energy levels reside outside the bandgap. We present experimental evidence that this enabling material property is present in the halide-lead perovskite, CH3NH3PbI3 (MAPbI3), consistent with theoretical predictions. By performing X-ray photoemission spectroscopy, we induce and track dynamic chemical and electronic transformations in the perovskite. These data show compositional changes that begin immediately with exposure to X-ray irradiation, whereas the predominant electronic structure of the thin film on compact TiO2 appears tolerant to the formation of compensating defect pairs of VI and VMA and for a large range of I/Pb ratios. Changing film composition is correlated with a shift of the valence-band maximum only as the halide-lead ratio drops below 2.5. This delay is attributed to the invariance of MAPbI3 electronic structure to distributed defects that can significantly transform the electronic density of states only when in high concentrations.

  19. Difference in oxidative stress tolerance between rice cultivars estimated with chlorophyll fluorescence analysis.

    Science.gov (United States)

    Kasajima, Ichiro

    2017-04-26

    Oxidative stress is considered to be involved in growth retardation of plants when they are exposed to a variety of biotic and abiotic stresses. Despite its potential importance in improving crop production, comparative studies on oxidative stress tolerance between rice (Oryza sativa L.) cultivars are limited. This work describes the difference in term of oxidative stress tolerance between 72 rice cultivars. 72 rice cultivars grown under naturally lit greenhouse were used in this study. Excised leaf discs were subjected to a low concentration of methyl viologen (paraquat), a chemical reagent known to generate reactive oxygen species in chloroplast. Chlorophyll fluorescence analysis using a two-dimensional fluorescence meter, ion leakage analysis as well as the measurement of chlorophyll contents were used to evaluate the oxidative stress tolerance of leaf discs. Furthermore, fluorescence intensities were finely analyzed based on new fluorescence theories that we have optimized. Treatment of leaf discs with methyl viologen caused differential decrease of maximum quantum yield of photosystem II (Fv/Fm) between cultivars. Decrease of Fv/Fm was also closely correlated with increase of ion leakage and decrease of chlorophyll a/b ratio. Fv/Fm was factorized into photochemical and non-photochemical parameters to classify rice cultivars into sensitive and tolerant ones. Among the 72 compared rice cultivars, the traditional cultivar Co13 was identified as the most tolerant to oxidative stress. Koshihikari, a dominant modern Japonica cultivar in Japan as well as IR58, one of the modern Indica breeding lines exhibited a strong tolerance to oxidative stress. Close correlation between Fv/Fm and chlorophyll a/b ratio provides a simple method to estimate oxidative stress tolerance, without measurement of chlorophyll fluorescence with special equipment. The fact that modern cultivars, especially major cultivars possessed tolerance to oxidative stress suggests that oxidative stress

  20. Single Temperature Sensor Superheat Control Using a Novel Maximum Slope-seeking Method

    DEFF Research Database (Denmark)

    Vinther, Kasper; Rasmussen, Henrik; Izadi-Zamanabadi, Roozbeh

    2013-01-01

    Superheating of refrigerant in the evaporator is an important aspect of safe operation of refrigeration systems. The level of superheat is typically controlled by adjusting the flow of refrigerant using an electronic expansion valve, where the superheat is calculated using measurements from...... a pressure and a temperature sensor. In this paper we show, through extensive testing, that the superheat or filling of the evaporator can actually be controlled using only a single temperature sensor. This can either reduce commissioning costs by lowering the necessary amount of sensors or add fault...... tolerance in existing systems if a sensor fails (e.g. pressure sensor). The solution is based on a novel maximum slope-seeking control method, where a perturbation signal is added to the valve opening degree, which gives additional information about the system for control purposes. Furthermore, the method...

  1. "Bringing Up Baby" to Tolerate Germs.

    Science.gov (United States)

    Nagao, Keisuke; Segre, Julia A

    2015-11-17

    How immune tolerance is maintained in the skin remains unclear. In this issue of Immunity, Rosenblum and colleagues demonstrate that tolerance to commensal bacteria is established during the neonatal period via regulatory T cells. Defining the crucial window during which commensal-specific tolerance is achieved has strategic implications for the induction of tolerance in allergic diseases. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. In silico comparison of the reproducibility of full-arch implant provisional restorations to final restoration between a 3D Scan/CAD/CAM technique and the conventional method.

    Science.gov (United States)

    Mino, Takuya; Maekawa, Kenji; Ueda, Akihiro; Higuchi, Shizuo; Sejima, Junichi; Takeuchi, Tetsuo; Hara, Emilio Satoshi; Kimura-Ono, Aya; Sonoyama, Wataru; Kuboki, Takuo

    2015-04-01

    The aim of this article was to investigate the accuracy in the reproducibility of full-arch implant provisional restorations to final restorations between a 3D Scan/CAD/CAM technique and the conventional method. We fabricated two final restorations for rehabilitation of maxillary and mandibular complete edentulous area and performed a computer-based comparative analysis of the accuracy in the reproducibility of the provisional restoration to final restoration between a 3D scanning and CAD/CAM (Scan/CAD/CAM) technique and the conventional silicone-mold transfer technique. Final restorations fabricated either by the conventional or Scan/CAD/CAM method were successfully installed in the patient. The total concave/convex volume discrepancy observed with the Scan/CAD/CAM technique was 503.50mm(3) and 338.15 mm(3) for maxillary and mandibular implant-supported prostheses (ISPs), respectively. On the other hand, total concave/convex volume discrepancy observed with the conventional method was markedly high (1106.84 mm(3) and 771.23 mm(3) for maxillary and mandibular ISPs, respectively). The results of the present report suggest that Scan/CAD/CAM method enables a more precise and accurate transfer of provisional restorations to final restorations compared to the conventional method. Copyright © 2014 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

  3. Tipología de las bibliotecas argentinas desde el período hispánico hasta 1830: Una primera clasificación provisional Typology of the Argentine Libraries since the Hispanic Period to 1830: A First Provisional Classification

    Directory of Open Access Journals (Sweden)

    Alejandro E. Parada

    2003-12-01

    Full Text Available El presente artículo intenta trazar una breve clasificación de los distintos «tipos» de bibliotecas existentes en el actual territorio argentino durante la dominación hispánica hasta el año 1830. La tipología adoptada es, ante todo, una aproximación provisional y ampliamente perfectible. La contribución se dirige, en líneas generales, a quienes se inician en el estudio de la «Historia del libro, de las bibliotecas y de la lectura» en la Argentina. En este sentido, la bibliografía citada intenta suplir la falta de guías de estudio sobre esta temática. Las bibliotecas identificadas son las siguientes: de instituciones o corporaciones religiosas, particulares, pública catedralicia, pública conventual, pública, de sociedades de extranjeros (societarias, de institutos de enseñanza, circulantes (y gabinetes de lectura, y por encargo u ofrecidas por negociantes.This article tries to outline a brief classification of the different types of existing libraries in the present Argentine territory since the Hispanic domination to 1830. The typology adopted is, above all, a provisional approach greatly rectifiable. The contribution is aimed, in general terms, to whom start the study of the history of the books, libraries, and reading in Argentina. In that sense, the quoted bibliography tries to substitute the lack of study guides on the subject. The identified libraries belong to: institutions or religious corporations; private individuals; foreigners societies (i.e.: belonging to a society; educational institutes; and cathedral public libraries; conventual public libraries; public libraries; circulating libraries (and reading rooms; and libraries made to order or offered by businessmen.

  4. Chlorophyll fluorescence emission as a reporter on cold tolerance in Arabidopsis thaliana accessions.

    Science.gov (United States)

    Mishra, Anamika; Mishra, Kumud B; Höermiller, Imke I; Heyer, Arnd G; Nedbal, Ladislav

    2011-02-01

    Non-invasive, high-throughput screening methods are valuable tools in breeding for abiotic stress tolerance in plants. Optical signals such as chlorophyll fluorescence emission can be instrumental in developing new screening techniques. In order to examine the potential of chlorophyll fluorescence to reveal plant tolerance to low temperatures, we used a collection of nine Arabidopsis thaliana accessions and compared their fluorescence features with cold tolerance quantified by the well established electrolyte leakage method on detached leaves. We found that, during progressive cooling, the minimal chlorophyll fluorescence emission rose strongly and that this rise was highly dependent on the cold tolerance of the accessions. Maximum quantum yield of PSII photochemistry and steady state fluorescence normalized to minimal fluorescence were also highly correlated to the cold tolerance measured by the electrolyte leakage method. In order to further increase the capacity of the fluorescence detection to reveal the low temperature tolerance, we applied combinatorial imaging that employs plant classification based on multiple fluorescence features. We found that this method, by including the resolving power of several fluorescence features, can be well employed to detect cold tolerance already at mild sub-zero temperatures. Therefore, there is no need to freeze the screened plants to the largely damaging temperatures of around -15°C. This, together with the method's easy applicability, represents a major advantage of the fluorescence technique over the conventional electrolyte leakage method. 

  5. Unique preservative tolerance in Tyromyces palustris

    Science.gov (United States)

    Frederick Green; Rachel A. Arango; Carol A. Clausen

    2005-01-01

    Fungal tolerance to wood preservatives has been critically important for many years. The tolerance of type cultures to common wood preservatives is, in fact, noted in the AWPA Standards [1]. Gloeophyllum trabeum Mad-617, for example, is particularly tolerant to phenolic and arsenic compounds. One important group of decay fungi that has been studied extensively are...

  6. 76 FR 38036 - Propylene Oxide; Pesticide Tolerances

    Science.gov (United States)

    2011-06-29

    ... AGENCY 40 CFR Part 180 Propylene Oxide; Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This regulation amends the propylene oxide tolerance on ``nut, tree, group...), announcing the Agency's proposal to amend the propylene oxide tolerance (40 CFR 180.491) on ``nut, tree...

  7. Increasing ideological tolerance in social psychology.

    Science.gov (United States)

    Inbar, Yoel; Lammers, Joris

    2015-01-01

    We argue that recognizing current ideological diversity in social psychology and promoting tolerance of minority views is just as important as increasing the number of non-liberal researchers. Increasing tolerance will allow individuals in the minority to express dissenting views, which will improve psychological science by reducing bias. We present four recommendations for increasing tolerance.

  8. 76 FR 27268 - Glyphosate; Pesticide Tolerance

    Science.gov (United States)

    2011-05-11

    ... AGENCY 40 CFR Part 180 Glyphosate; Pesticide Tolerance AGENCY: Environmental Protection Agency (EPA... glyphosate in or on corn, field, forage. Monsanto Company requested this tolerance under the Federal Food... tolerance for residues of the herbicide glyphosate, N-(phosphonomethyl) glycine, in or on corn, field...

  9. 78 FR 25396 - Glyphosate; Pesticide Tolerances

    Science.gov (United States)

    2013-05-01

    ... AGENCY 40 CFR Part 180 Glyphosate; Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This regulation establishes tolerances for residues of glyphosate in or on... CFR 180.364 be amended by establishing tolerances for residues of the herbicide glyphosate N...

  10. 75 FR 40741 - Hexythiazox; Pesticide Tolerances

    Science.gov (United States)

    2010-07-14

    ... the existing separate tolerance for fresh, prune, plums at 0.1 parts per million (ppm); revising the tolerance in or on plum, prune, dried from 0.4 to 1.3 ppm; and by revising the tolerance in or on grapes..., ornamental landscape plantings, ornamental plants, trees and vines in nurseries, residential fruit trees, nut...

  11. Tolerance to insect defoliation: biocenotic aspects

    Science.gov (United States)

    Andrey A. Pleshanov; Victor I. Voronin; Elena S. Khlimankova; Valentina I. Epova

    1991-01-01

    Woody plant resistance to insect damage is of great importance in forest protection, and tree tolerance is an important element of this resistance. The compensating mechanisms responsible for tolerance are nonspecific as a rule and develop after damage has been caused by phytophagous animals or other unfavorable effects. Beyond that, plant tolerance depends on duration...

  12. Zero Tolerance in Tennessee Schools: An Update.

    Science.gov (United States)

    Potts, Kim; Njie, Bintou; Detch, Ethel R.; Walton, Jason

    As required by Tennessee law, this report examines the state's zero-tolerance disciplinary data collected by the Tennessee Department of Education for school years 1999-00, 2000-01, and 2001-02. The first section displays statewide zero-tolerance statistics. The second section focuses on the zero-tolerance statistics of Tennessee's five major…

  13. Fault Tolerant External Memory Algorithms

    DEFF Research Database (Denmark)

    Jørgensen, Allan Grønlund; Brodal, Gerth Stølting; Mølhave, Thomas

    2009-01-01

    bound on the number of I/Os required for any deterministic dictionary that is resilient to memory faults. We design a static and a dynamic deterministic dictionary with optimal query performance as well as an optimal sorting algorithm and an optimal priority queue. Finally, we consider scenarios where......Algorithms dealing with massive data sets are usually designed for I/O-efficiency, often captured by the I/O model by Aggarwal and Vitter. Another aspect of dealing with massive data is how to deal with memory faults, e.g. captured by the adversary based faulty memory RAM by Finocchi and Italiano....... However, current fault tolerant algorithms do not scale beyond the internal memory. In this paper we investigate for the first time the connection between I/O-efficiency in the I/O model and fault tolerance in the faulty memory RAM, and we assume that both memory and disk are unreliable. We show a lower...

  14. Copper tolerance of Trichoderma species

    Directory of Open Access Journals (Sweden)

    Jovičić-Petrović Jelena

    2014-01-01

    Full Text Available Some Trichoderma strains can persist in ecosystems with high concentrations of heavy metals. The aim of this research was to examine the variability of Trichoderma strains isolated from different ecosystems, based on their morphological properties and restriction analysis of ITS fragments. The fungal growth was tested on potato dextrose agar, amended with Cu(II concentrations ranging from 0.25 to 10 mmol/l, in order to identify copper-resistant strains. The results indicate that some isolated strains of Trichoderma sp. show tolerance to higher copper concentrations. Further research to examine the ability of copper bioaccumulation by tolerant Trichoderma strains is needed. [Projekat Ministarstva nauke Republike Srbije, br. TR 31080 i br. III 43010

  15. Antimicrobial Tolerance in Listeria monocytogenes

    DEFF Research Database (Denmark)

    Curtis, Thomas Darwin

    There are two ways in which bacteria survive killing by antibiotics. The most well-known, is antibiotic resistance, which results from the acquisition of a resistance gene or mutation that allows bacteria to grow and divide in the presence of antibiotic concentrations that would normally kill other...... bacteria. Antibiotic tolerance on the other hand, is the ability of bacteria to survive (but not grow) prolonged exposure to concentrations that should normally kill them. The predominant mechanism underlying tolerance is the so-called persister cell, a small subpopulation of dormant like cells...... mechanisms in this organism. The body of work over the course of this PhD study has been organized into three manuscripts, which are summarized below. The first manuscript sought to link the Small Colony Variant (SCV) to persister cells in L. monocytogenes. SCV cells of bacteria are a slow growing phenotype...

  16. Anhydrobiosis and Freezing-Tolerance

    DEFF Research Database (Denmark)

    McGill, Lorraine; Shannon, Adam; Pisani, Davide

    2015-01-01

    isolated from Ross Island Antarctica, can survive intracellular ice formation when fully hydrated. A capacity to survive freezing while fully hydrated has also been observed in some other Antarctic nematodes. We experimentally determined the anhydrobiotic and freezing-tolerance phenotypes of 24......Anhydrobiotic animals can survive the loss of both free and bound water from their cells. While in this state they are also resistant to freezing. This physiology adapts anhydrobiotes to harsh environments and it aids their dispersal. Panagrolaimus davidi, a bacterial feeding anhydrobiotic nematode...... Panagrolaimus strains from tropical, temperate, continental and polar habitats and we analysed their phylogenetic relationships. We found that several other Panagrolaimus isolates can also survive freezing when fully hydrated and that tissue extracts from these freezing-tolerant nematodes can inhibit the growth...

  17. Modelling Accident Tolerant Fuel Concepts

    Energy Technology Data Exchange (ETDEWEB)

    Hales, Jason Dean [Idaho National Laboratory; Gamble, Kyle Allan Lawrence [Idaho National Laboratory

    2016-05-01

    The catastrophic events that occurred at the Fukushima-Daiichi nuclear power plant in 2011 have led to widespread interest in research of alternative fuels and claddings that are proposed to be accident tolerant. The United States Department of Energy (DOE) through its Nuclear Energy Advanced Modeling and Simulation (NEAMS) program has funded an Accident Tolerant Fuel (ATF) High Impact Problem (HIP). The ATF HIP is a three-year project to perform research on two accident tolerant concepts. The final outcome of the ATF HIP will be an in-depth report to the DOE Advanced Fuels Campaign (AFC) giving a recommendation on whether either of the two concepts should be included in their lead test assembly scheduled for placement into a commercial reactor in 2022. The two ATF concepts under investigation in the HIP are uranium silicide fuel and iron-chromium-aluminum (FeCrAl) alloy cladding. Utilizing the expertise of three national laboratory participants (Idaho National Laboratory, Los Alamos National Laboratory, and Argonne National Laboratory), a comprehensive multiscale approach to modeling is being used that includes atomistic modeling, molecular dynamics, rate theory, phase-field, and fuel performance simulations. Model development and fuel performance analysis are critical since a full suite of experimental studies will not be complete before AFC must prioritize concepts for focused development. In this paper, we present simulations of the two proposed accident tolerance fuel systems: U3Si2 fuel with Zircaloy-4 cladding, and UO2 fuel with FeCrAl cladding. Sensitivity analyses are completed using Sandia National Laboratories’ Dakota software to determine which input parameters (e.g., fuel specific heat) have the greatest influence on the output metrics of interest (e.g., fuel centerline temperature). We also outline the multiscale modelling approach being employed. Considerable additional work is required prior to preparing the recommendation report for the Advanced

  18. TEMPERATURE TOLERANCES AND OSMOREGULATION IN ...

    African Journals Online (AJOL)

    MQCOmQ IItora/I' and P,ammotelllllll capelUis) have upper lethal temperatures of 4l-46°C when heated at a rate of 1 CO/lO minutes. TWo species have upper lethal temperatures of 37°C and 39°C when heated at a rate of 1 CO/day. It has been concluded that they can tolerate much hisher temperatures thaD they normally ...

  19. Rawls, reasonableness, and international toleration

    OpenAIRE

    Porter, Thomas

    2012-01-01

    Rawls's account of international toleration in The Law of Peoples has been the subject of vigorous critiques by critics who believe that he unacceptably dilutes the principles of his Law of Peoples in order to accommodate non-liberal societies. One important component in these critiques takes issue specifically with Rawls's inclusion of certain non-liberal societies ('decent peoples') in the constituency of justification for the Law of Peoples. In Rawls's defence, I argue that the explanation...

  20. Fault Tolerant Wind Farm Control

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh; Stoustrup, Jakob

    2013-01-01

    In the recent years the wind turbine industry has focused on optimizing the cost of energy. One of the important factors in this is to increase reliability of the wind turbines. Advanced fault detection, isolation and accommodation are important tools in this process. Clearly most faults are deal...... scenarios. This benchmark model is used in an international competition dealing with Wind Farm fault detection and isolation and fault tolerant control....

  1. The power and robustness of maximum LOD score statistics.

    Science.gov (United States)

    Yoo, Y J; Mendell, N R

    2008-07-01

    The maximum LOD score statistic is extremely powerful for gene mapping when calculated using the correct genetic parameter value. When the mode of genetic transmission is unknown, the maximum of the LOD scores obtained using several genetic parameter values is reported. This latter statistic requires higher critical value than the maximum LOD score statistic calculated from a single genetic parameter value. In this paper, we compare the power of maximum LOD scores based on three fixed sets of genetic parameter values with the power of the LOD score obtained after maximizing over the entire range of genetic parameter values. We simulate family data under nine generating models. For generating models with non-zero phenocopy rates, LOD scores maximized over the entire range of genetic parameters yielded greater power than maximum LOD scores for fixed sets of parameter values with zero phenocopy rates. No maximum LOD score was consistently more powerful than the others for generating models with a zero phenocopy rate. The power loss of the LOD score maximized over the entire range of genetic parameters, relative to the maximum LOD score calculated using the correct genetic parameter value, appeared to be robust to the generating models.

  2. Time course of learning to produce maximum cycling power.

    Science.gov (United States)

    Martin, J C; Diedrich, D; Coyle, E F

    2000-10-01

    The purpose of this investigation was to determine the time course and magnitude of learning effects associated with repeated maximum cycling power tests and to determine if cycle-trained men exhibit different learning effects than active men who are not cycle-trained. Cycle-trained (N = 13) and active men (N = 35) performed short maximal cycling bouts 4 times per day for 4 consecutive days. Inertial load cycle ergometry was used to measure maximum power and pedaling rate at maximum power. Maximum power of the cycle-trained men did not differ across days or bouts. Maximum power of the active men increased 7 % within the first day and 7 % from the mean of day one to day three. Pedaling rate at maximum power did not differ across days or bouts in either the cycle-trained or active men. These results demonstrate that valid and reliable results for maximum cycling power can be obtained from cycle-trained men in a single day, whereas active men require at least 2 days of practice in order to produce valid and reliable values.

  3. Maximum nonlocality in the (3,2,2) scenario

    Science.gov (United States)

    López-Rosa, Sheila; Xu, Zhen-Peng; Cabello, Adán

    2016-12-01

    We identify the simplest combinations of entanglement and incompatibility giving the maximum quantum violation for each of the 46 classes of tight Bell inequalities for the (3,2,2) scenario, i.e., three parties, two measurements per party, and two outcomes per measurement. This allows us to classify the maximum quantum nonlocality according to the simplest resources needed to achieve it. We show that entanglement and incompatibility only produce maximum nonlocality when they are combined in specific ways. For each entanglement class there is, in most cases, just one incompatibility class leading to maximum nonlocality. We also identify two interesting cases. We show that the maximum quantum violation of Śliwa inequality 23 only occurs when the third party measures the identity, so nonlocality cannot increase when we add a third party to the bipartite case. Almost quantum correlations predict that adding a new party increases nonlocality. This points out that either almost quantum correlations violate a fundamental principle or that there is a form of tripartite entanglement which quantum theory cannot account for. The other interesting case is the maximum quantum violation of Śliwa inequality 26, which, like the Mermin inequality, requires maximum incompatibility for all parties. In contrast, it requires a specific entangled state which has the same tripartite negativity as the W state.

  4. SALT TOLERANCE OF CROP PLANTS

    Directory of Open Access Journals (Sweden)

    Hamdia, M. A

    2010-09-01

    Full Text Available Several environmental factors adversely affect plant growth and development and final yield performance of a crop. Drought, salinity, nutrient imbalances (including mineral toxicities and deficiencies and extremes of temperature are among the major environmental constraints to crop productivity worldwide. Development of crop plants with stress tolerance, however, requires, among others, knowledge of the physiological mechanisms and genetic controls of the contributing traits at different plant developmental stages. In the past 2 decades, biotechnology research has provided considerable insights into the mechanism of biotic stress tolerance in plants at the molecular level. Furthermore, different abiotic stress factors may provoke osmotic stress, oxidative stress and protein denaturation in plants, which lead to similar cellular adaptive responses such as accumulation of compatible solutes, induction of stress proteins, and acceleration of reactive oxygen species scavenging systems. Recently, the authores try to improve plant tolerance to salinity injury through either chemical treatments (plant hormones, minerals, amino acids, quaternary ammonium compounds, polyamines and vitamins or biofertilizers treatments (Asymbiotic nitrogen-fixing bacteria, symbiotic nitrogen-fixing bacteria and mycorrhiza or enhanced a process used naturally by plants to minimise the movement of Na+ to the shoot, using genetic modification to amplify the process, helping plants to do what they already do - but to do it much better."

  5. Maximum-J capability in a quasi-axisymmetric stellarator

    Energy Technology Data Exchange (ETDEWEB)

    Yokoyama, M.; Itoh, K.; Okamura, S.; Matsuoka, K. [National Inst. for Fusion Science, Toki, Gifu (Japan); Itoh, S.-I. [Kyushu Univ., Fukuoka (Japan). Research Inst. for Applied Mechanics

    2001-05-01

    Maximum-J (J is the second adiabatic invariant) capability, i,e., the radial derivative of J has the same sign as that of pressure, is investigated in a quasi-axisymmetric (QA) stellarator to investigate improved confinement. Due to the existence of non-axisymmetry of the magnetic field strength, a local maximum of J is created to cause the drift reversal. External controllability of Maximum-J condition is also demonstrated, by which impact of magnetic configuration on turbulent transport can be studied. (author)

  6. Maximum-J capability in a quasiaxisymmetric stellarator.

    Science.gov (United States)

    Yokoyama, M; Itoh, K; Okamura, S; Matsuoka, K; Itoh, S I

    2001-07-01

    Maximum-J (J is the second adiabatic invariant) capability, i.e., the radial derivative of J has the same sign as that of pressure, is investigated in a quasiaxisymmetric (QA) stellarator to investigate improved confinement. Due to the existence of nonaxisymmetry of the magnetic field strength, a local maximum of J is created to cause the drift reversal. External controllability of the maximum-J condition is also demonstrated, by which the impact of magnetic configuration on turbulent transport can be studied.

  7. An evaluation of Panicum maximum cv. Gatton: 3. The partial ...

    African Journals Online (AJOL)

    An evaluation of Panicum maximum cv. Gatton: 3. The partial digestion by sheep of organic matter, nitrogen and neutral detergent fibre of herbage at three stages of maturity during summer, autumn or winter.

  8. Efficiency at maximum power of motor traffic on networks

    Science.gov (United States)

    Golubeva, N.; Imparato, A.

    2014-06-01

    We study motor traffic on Bethe networks subject to hard-core exclusion for both tightly coupled one-state machines and loosely coupled two-state machines that perform work against a constant load. In both cases we find an interaction-induced enhancement of the efficiency at maximum power (EMP) as compared to noninteracting motors. The EMP enhancement occurs for a wide range of network and single-motor parameters and is due to a change in the characteristic load-velocity relation caused by phase transitions in the system. Using a quantitative measure of the trade-off between the EMP enhancement and the corresponding loss in the maximum output power we identify parameter regimes where motor traffic systems operate efficiently at maximum power without a significant decrease in the maximum power output due to jamming effects.

  9. Environmental Monitoring, Water Quality - Total Maximum Daily Load (TMDL)

    Data.gov (United States)

    NSGIC Education | GIS Inventory — The Clean Water Act Section 303(d) establishes the Total Maximum Daily Load (TMDL) program. The purpose of the TMDL program is to identify sources of pollution and...

  10. Post optimization paradigm in maximum 3-satisfiability logic programming

    Science.gov (United States)

    Mansor, Mohd. Asyraf; Sathasivam, Saratha; Kasihmuddin, Mohd Shareduwan Mohd

    2017-08-01

    Maximum 3-Satisfiability (MAX-3SAT) is a counterpart of the Boolean satisfiability problem that can be treated as a constraint optimization problem. It deals with a conundrum of searching the maximum number of satisfied clauses in a particular 3-SAT formula. This paper presents the implementation of enhanced Hopfield network in hastening the Maximum 3-Satisfiability (MAX-3SAT) logic programming. Four post optimization techniques are investigated, including the Elliot symmetric activation function, Gaussian activation function, Wavelet activation function and Hyperbolic tangent activation function. The performances of these post optimization techniques in accelerating MAX-3SAT logic programming will be discussed in terms of the ratio of maximum satisfied clauses, Hamming distance and the computation time. Dev-C++ was used as the platform for training, testing and validating our proposed techniques. The results depict the Hyperbolic tangent activation function and Elliot symmetric activation function can be used in doing MAX-3SAT logic programming.

  11. Ethylene Production Maximum Achievable Control Technology (MACT) Compliance Manual

    Science.gov (United States)

    This July 2006 document is intended to help owners and operators of ethylene processes understand and comply with EPA's maximum achievable control technology standards promulgated on July 12, 2002, as amended on April 13, 2005 and April 20, 2006.

  12. Solar Panel Maximum Power Point Tracker for Power Utilities

    National Research Council Canada - National Science Library

    Sandeep Banik; Dr P.K.Saha

    2014-01-01

    ―Solar Panel Maximum Power Point Tracker For power utilities‖ As the name implied, it is a photovoltaic system that uses the photovoltaic array as a source of electrical power supply and since every photovoltaic (PV...

  13. A stochastic model for the analysis of maximum daily temperature

    Science.gov (United States)

    Sirangelo, B.; Caloiero, T.; Coscarelli, R.; Ferrari, E.

    2017-10-01

    In this paper, a stochastic model for the analysis of the daily maximum temperature is proposed. First, a deseasonalization procedure based on the truncated Fourier expansion is adopted. Then, the Johnson transformation functions were applied for the data normalization. Finally, the fractionally autoregressive integrated moving average model was used to reproduce both short- and long-memory behavior of the temperature series. The model was applied to the data of the Cosenza gauge (Calabria region) and verified on other four gauges of southern Italy. Through a Monte Carlo simulation procedure based on the proposed model, 105 years of daily maximum temperature have been generated. Among the possible applications of the model, the occurrence probabilities of the annual maximum values have been evaluated. Moreover, the procedure was applied for the estimation of the return periods of long sequences of days with maximum temperature above prefixed thresholds.

  14. Scale Reduction Techniques for Computing Maximum Induced Bicliques

    Directory of Open Access Journals (Sweden)

    Shahram Shahinpour

    2017-10-01

    Full Text Available Given a simple, undirected graph G, a biclique is a subset of vertices inducing a complete bipartite subgraph in G. In this paper, we consider two associated optimization problems, the maximum biclique problem, which asks for a biclique of the maximum cardinality in the graph, and the maximum edge biclique problem, aiming to find a biclique with the maximum number of edges in the graph. These NP-hard problems find applications in biclustering-type tasks arising in complex network analysis. Real-life instances of these problems often involve massive, but sparse networks. We develop exact approaches for detecting optimal bicliques in large-scale graphs that combine effective scale reduction techniques with integer programming methodology. Results of computational experiments with numerous real-life network instances demonstrate the performance of the proposed approach.

  15. Prediction of Maximum Aerobic Power in Untrained Females

    Science.gov (United States)

    Dolgener, Forrest A.

    1978-01-01

    The author presents an equation for predicting maximum aerobic power in untrained females from values of percent body fat, weight, and submaximal values of heart rate, respiratory quotient, and expired gas. (MJB)

  16. Water Quality Assessment and Total Maximum Daily Loads Information (ATTAINS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Water Quality Assessment TMDL Tracking And Implementation System (ATTAINS) stores and tracks state water quality assessment decisions, Total Maximum Daily Loads...

  17. Single-ion heat engine at maximum power.

    Science.gov (United States)

    Abah, O; Rossnagel, J; Jacob, G; Deffner, S; Schmidt-Kaler, F; Singer, K; Lutz, E

    2012-11-16

    We propose an experimental scheme to realize a nanoheat engine with a single ion. An Otto cycle may be implemented by confining the ion in a linear Paul trap with tapered geometry and coupling it to engineered laser reservoirs. The quantum efficiency at maximum power is analytically determined in various regimes. Moreover, Monte Carlo simulations of the engine are performed that demonstrate its feasibility and its ability to operate at a maximum efficiency of 30% under realistic conditions.

  18. The Maximum Caliber principle applied to continuous systems

    Science.gov (United States)

    González, Diego; Davis, Sergio

    2016-05-01

    We give a brief presentation of the maximization of path entropy (Maximum Caliber) formalism as an approach to inference over trajectories. We develop its continuoustime version involving path integrals and present an identity between expectations over the most unbiased probability distribution of trajectories. This relation between expectations can be used to solve for the Lagrange multipliers in a Maximum Caliber problem without the need for the dynamical partition function.

  19. The maximum cooling density of a realistic Stirling refrigerator

    Science.gov (United States)

    Berrin Erbay, L.; Yavuz, Hasbi

    1998-02-01

    The maximum cooling density of a Stirling refrigerator operating in a closed regenerative thermodynamic cycle is presented in this paper. The cooling density is the cooling load per unit volume of the refrigerator. Since the size of the refrigerator is involved in the cooling density, the maximization of the cooling density has given a critical compression ratio. The maximum cooling density serves as a better comparison criterion for thermoeconomic considerations.

  20. Determining Dynamical Path Distributions usingMaximum Relative Entropy

    Science.gov (United States)

    2015-05-31

    the observable constraint which in this case is not a Dirac delta function but a Kronecker delta function, δjj′ , qij′ is the discrete Bayesian prior...information. MaxCal is just The Principle of Maximum Entropy (MaxEnt) where constraints are changing in time. This simply amounts to an additional...is just The Principle of Maximum Entropy (MaxEnt) where constraints are changing in time. This simply amounts to an additional step to summarize the