Next Generation NASA Initiative for Space Geodesy

Science.gov (United States)

Merkowitz, S. M.; Desai, S.; Gross, R. S.; Hilliard, L.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry J. F.; Murphy, D.; Noll, C. E.;

Next generation CANDU plants

International Nuclear Information System (INIS)

Hedges, K.R.; Yu, S.K.W.

1998-01-01

Future CANDU designs will continue to meet the emerging design and performance requirements expected by the operating utilities. The next generation CANDU products will integrate new technologies into both the product features as well as into the engineering and construction work processes associated with delivering the products. The timely incorporation of advanced design features is the approach adopted for the development of the next generation of CANDU. AECL's current products consist of 700MW Class CANDU 6 and 900 MW Class CANDU 9. Evolutionary improvements are continuing with our CANDU products to enhance their adaptability to meet customers ever increasing need for higher output. Our key product drivers are for improved safety, environmental protection and improved cost effectiveness. Towards these goals we have made excellent progress in Research and Development and our investments are continuing in areas such as fuel channels and passive safety. Our long term focus is utilizing the fuel cycle flexibility of CANDU reactors as part of the long term energy mix

Design reliability assurance program for Korean next generation reactor

International Nuclear Information System (INIS)

Lee, Beom-Su; Han, Jin-Kyu; Na, Jang Hwan; Yoo, Kyung Yeong

1997-01-01

The Korean Next Generation Reactor (KNGR) project is to develop standardized nuclear power plant design for the construction of future nuclear power plants in Korea. The main purpose of the KNGR project is to develop the advanced nuclear power plants, which enhance safety and economics significantly through the incorporation of design concepts for severe accident prevention and mitigation, supplementary passive safety concept, simplification and application of modularization and so on. For those, Probabilistic Safety Assessment (PSA) and availability study will be performed at the early stage of the design, and the Design Reliability Assurance Program (D-RAP) is applied in the development of the KNGR to ensure that the safety and availability evaluated in the PSA and availability study at the early phase of the design is maintained through the detailed design, construction, procurement and operation of the plants. This paper presents the D-RAP concept that could be applied at the stage of the basic design of the nuclear power plants, based on the models for the reference plants and/or similar plants. 4 refs., 1 fig

Next Generation Nuclear Plant (NGNP) Prismatic HTGR Conceptual Design Project - Final Technical Report

Energy Technology Data Exchange (ETDEWEB)

Saurwein, John

2011-07-15

This report is the Final Technical Report for the Next Generation Nuclear Plant (NGNP) Prismatic HTGR Conceptual Design Project conducted by a team led by General Atomics under DOE Award DE-NE0000245. The primary overall objective of the project was to develop and document a conceptual design for the Steam Cycle Modular Helium Reactor (SC-MHR), which is the reactor concept proposed by General Atomics for the NGNP Demonstration Plant. The report summarizes the project activities over the entire funding period, compares the accomplishments with the goals and objectives of the project, and discusses the benefits of the work. The report provides complete listings of the products developed under the award and the key documents delivered to the DOE.

Next Generation Nuclear Plant (NGNP) Prismatic HTGR Conceptual Design Project - Final Technical Report

International Nuclear Information System (INIS)

Saurwein, J.

2011-01-01

This report is the Final Technical Report for the Next Generation Nuclear Plant (NGNP) Prismatic HTGR Conceptual Design Project conducted by a team led by General Atomics under DOE Award DE-NE0000245. The primary overall objective of the project was to develop and document a conceptual design for the Steam Cycle Modular Helium Reactor (SC-MHR), which is the reactor concept proposed by General Atomics for the NGNP Demonstration Plant. The report summarizes the project activities over the entire funding period, compares the accomplishments with the goals and objectives of the project, and discusses the benefits of the work. The report provides complete listings of the products developed under the award and the key documents delivered to the DOE.

Design option of heat exchanger for the next generation nuclear plant - HTR2008-58175

International Nuclear Information System (INIS)

Oh, C. H.; Kim, E. S.

2008-01-01

The Next Generation Nuclear Plant (NGNP), a very High temperature Gas-Cooled Reactor (VHTR) concept, will provide the first demonstration of a closed-loop Brayton cycle at a commercial scale, producing a few hundred megawatts of power in the form of electricity and hydrogen. The power conversion unit (PCU) for the NGNP will take advantage of the significantly higher reactor outlet temperatures of the VHTRs to provide higher efficiencies than can be achieved with the current generation of light water reactors. Besides demonstrating a system design that can be used directly for subsequent commercial deployment, the NGNP will demonstrate key technology elements that can be used in subsequent advanced power conversion systems for other Generation IV reactors. In anticipation of the design, development and procurement of an advanced power conversion system for the NGNP, the system integration of the NGNP and hydrogen plant was initiated to identify the important design and technology options that must be considered in evaluating the performance of the proposed NGNP. As part of the system integration of the VHTRs and the hydrogen production plant, the intermediate heat exchanger is used to transfer the process heat from VHTRs to the hydrogen plant. Therefore, the design and configuration of the intermediate heat exchanger is very important. This paper will include analysis of one stage versus two stage heat exchanger design configurations and simple stress analyses of a printed circuit heat exchanger (PCHE), helical coil heat exchanger, and shell/tube heat exchanger. (authors)

Design optimization of general arrangement in Korean next generation reactor

International Nuclear Information System (INIS)

Kim, S. H.; Jung, D. W.; Choi, Y. B.; Cho, S. J.

1999-01-01

In order to optimize the general arrangement(GA) of Korean Next Generation Reactor (KNGR), field opinions in domestic nuclear power plants have been collected, and the bench marking on UCN No.1,2 which were estimated to be the most excellent in view of operability and maintenance has been accomplished. Through this work, design optimization items for GA were reviewed. Major items to be selected for optimization are summarized as follows; 'Expanding the compound building function and the mezzanine floor concept in the auxiliary building', 'Including the diesel generator building to the auxiliary building', 'Change of the equipment removal method in the auxiliary building'. With these GA design optimization, the auxiliary building boundary will be improved as a complete rectangular type. The power block volume except the changing effect to the single containment structure will be reduced to about 10% in comparison with that of in KNGR phase II

RES-E-NEXT: Next Generation of RES-E Policy Instruments

Energy Technology Data Exchange (ETDEWEB)

Miller, M.; Bird, L.; Cochran, J.; Milligan, M.; Bazilian, M. [National Renewable Energy Laboratory, Golden, CO (United States); Denny, E.; Dillon, J.; Bialek, J.; O’Malley, M. [Ecar Limited (Ireland); Neuhoff, K. [DIW Berlin (Germany)

2013-07-04

The RES-E-NEXT study identifies policies that are required for the next phase of renewable energy support. The study analyses policy options that secure high shares of renewable electricity generation and adequate grid infrastructure, enhance flexibility and ensure an appropriate market design. Measures have limited costs or even save money, and policies can be gradually implemented.

Windmills by Design: Purposeful Curriculum Design to Meet Next Generation Science Standards in a 9-12 Physics Classroom

Science.gov (United States)

Concannon, James; Brown, Patrick L.

2017-01-01

The "Next Generation Science Standards" (NGSS) challenges science teachers to think beyond specific content standards when considering how to design and implement curriculum. This lesson, "Windmills by Design," is an insightful lesson in how science teachers can create and implement a cross-cutting lesson to teach the concepts…

Optical Subsystems for Next Generation Access Networks

DEFF Research Database (Denmark)

Lazaro, J.A; Polo, V.; Schrenk, B.

2011-01-01

Recent optical technologies are providing higher flexibility to next generation access networks: on the one hand, providing progressive FTTx and specifically FTTH deployment, progressively shortening the copper access network; on the other hand, also opening fixed-mobile convergence solutions...... in next generation PON architectures. It is provided an overview of the optical subsystems developed for the implementation of the proposed NG-Access Networks....

Cost and schedule reduction for next-generation Candu

International Nuclear Information System (INIS)

Hopwood, J.M.; Yu, S.; Pakan, M.; Soulard, M.

2002-01-01

AECL has developed a suite of technologies for Candu R reactors that enable the next step in the evolution of the Candu family of heavy-water-moderated fuel-channel reactors. These technologies have been combined in the design for the Advanced Candu Reactor TM1 (ACRTM), AECL's next generation Candu power plant. The ACR design builds extensively on the existing Candu experience base, but includes innovations, in design and in delivery technology, that provide very substantial reductions in capital cost and in project schedules. In this paper, main features of next generation design and delivery are summarized, to provide the background basis for the cost and schedule reductions that have been achieved. In particular the paper outlines the impact of the innovative design steps for ACR: - Selection of slightly enriched fuel bundle design; - Use of light water coolant in place of traditional Candu heavy water coolant; - Compact core design with unique reactor physics benefits; - Optimized coolant and turbine system conditions. In addition to the direct cost benefits arising from efficiency improvement, and from the reduction in heavy water, the next generation Candu configuration results in numerous additional indirect cost benefits, including: - Reduction in number and complexity of reactivity mechanisms; - Reduction in number of heavy water auxiliary systems; - Simplification in heat transport and its support systems; - Simplified human-machine interface. The paper also describes the ACR approach to design for constructability. The application of module assembly and open-top construction techniques, based on Candu and other worldwide experience, has been proven to generate savings in both schedule durations and overall project cost, by reducing premium on-site activities, and by improving efficiency of system and subsystem assembly. AECL's up-to-date experience in the use of 3-D CADDS and related engineering tools has also been proven to reduce both engineering and

Safety reviews of next-generation light-water reactors

International Nuclear Information System (INIS)

Kudrick, J.A.; Wilson, J.N.

1997-01-01

The Nuclear Regulatory Commission (NRC) is reviewing three applications for design certification under its new licensing process. The U.S. Advanced Boiling Water Reactor (ABWR) and System 80+ designs have received final design approvals. The AP600 design review is continuing. The goals of design certification are to achieve early resolution of safety issues and to provide a more stable and predictable licensing process. NRC also reviewed the Utility Requirements Document (URD) of the Electric Power Research Institute (EPRI) and determined that its guidance does not conflict with NRC requirements. This review led to the identification and resolution of many generic safety issues. The NRC determined that next-generation reactor designs should achieve a higher level of safety for selected technical and severe accident issues. Accordingly, NRC developed new review standards for these designs based on (1) operating experience, including the accident at Three Mile Island, Unit 2; (2) the results of probabilistic risk assessments of current and next-generation reactor designs; (3) early efforts on severe accident rulemaking; and (4) research conducted to address previously identified generic safety issues. The additional standards were used during the individual design reviews and the resolutions are documented in the design certification rules. 12 refs

Technical presentation: Next Generation Oscilloscopes

CERN Multimedia

PH Department

2011-01-01

  Rohde & Schwarz "Next Generation Oscilloscopes" - Introduction and Presentation Agenda: Wednesday 23 March  -  09:30 to 11:30 (open end) Bldg. 13-2-005 Language: English 09.30 Presentation "Next Generation Oscilloscopes" from Rohde & Schwarz RTO / RTM in theory and practice Gerard Walker 10.15 Technical design details from R&D Dr. Markus Freidhof 10.45 Scope and Probe Roadmap (confidential) Guido Schulze 11.00 Open Discussion Feedback, first impression, wishes, needs and requirements from CERN All 11.30 Expert Talks, Hands on All Mr. Dr. Markus Freidhof, Head of R&D Oscilloscopes, Rohde & Schwarz, Germany; Mr. Guido Schulze, ...

Solving Large Scale Nonlinear Eigenvalue Problem in Next-Generation Accelerator Design

Energy Technology Data Exchange (ETDEWEB)

Liao, Ben-Shan; Bai, Zhaojun; /UC, Davis; Lee, Lie-Quan; Ko, Kwok; /SLAC

2006-09-28

A number of numerical methods, including inverse iteration, method of successive linear problem and nonlinear Arnoldi algorithm, are studied in this paper to solve a large scale nonlinear eigenvalue problem arising from finite element analysis of resonant frequencies and external Q{sub e} values of a waveguide loaded cavity in the next-generation accelerator design. They present a nonlinear Rayleigh-Ritz iterative projection algorithm, NRRIT in short and demonstrate that it is the most promising approach for a model scale cavity design. The NRRIT algorithm is an extension of the nonlinear Arnoldi algorithm due to Voss. Computational challenges of solving such a nonlinear eigenvalue problem for a full scale cavity design are outlined.

Designing Next Generation Telecom Regulation

DEFF Research Database (Denmark)

Henten, Anders; Samarajiva, Rohan

– ICT convergence regulation and multisector utility regulation. Whatever structure of next generation telecom regulation is adopted, all countries will need to pay much greater attention to the need for increased coordination of policy directions and regulatory activities both across the industries......Continuously expanding applications of information and communication technologies (ICT) are transforming local, national, regional and international economies into network economies, the foundation for information societies. They are being built upon expanded and upgraded national telecom networks...... to creating an environment to foster a massive expansion in the coverage and capabilities of the information infrastructure networks, with national telecom regulators as the key implementers of the policies of reform. The first phase of reform has focused on industry specific telecom policy and regulation...

Heterogeneous next-generation wireless network interference model-and its applications

KAUST Repository

Mahmood, Nurul Huda

2014-04-01

Next-generation wireless systems facilitating better utilisation of the scarce radio spectrum have emerged as a response to inefficient and rigid spectrum assignment policies. These are comprised of intelligent radio nodes that opportunistically operate in the radio spectrum of existing primary systems, yet unwanted interference at the primary receivers is unavoidable. In order to design efficient next-generation systems and to minimise the adverse effect of their interference, it is necessary to realise how the resulting interference impacts the performance of the primary systems. In this work, a generalised framework for the interference analysis of such a next-generation system is presented where the nextgeneration transmitters may transmit randomly with different transmit powers. The analysis is built around a model developed for the statistical representation of the interference at the primary receivers, which is then used to evaluate various performance measures of the primary system. Applications of the derived interference model in designing the next-generation network system parameters are also demonstrated. Such approach provides a unified and generalised framework, the use of which allows a wide range of performance metrics can be evaluated. Findings of the analytical performance analyses are confirmed through extensive computer-based Monte-Carlo simulations. © 2012 John Wiley & Sons, Ltd.

Considerations of severe accidents in the design of Korean Next Generation Reactor

International Nuclear Information System (INIS)

Dong Wook Jerng; Choong Sup Byun

1998-01-01

The severe accident is one of the key issues in the design of Korean Next Generation Reactor (KNGR) which is an evolutionary type of pressurized water reactor. As IAEA recommends in TECDOC-801, the design objective of KNGR with regard to safety is provide a sound technical basis by which an imminent off-site emergency response to any circumstance could be practically unnecessary. To implement this design objective, probabilistic safety goals were established and design requirements were developed for systems to mitigate severe accidents. The basic approach of KNGR to address severe accidents is firstly prevent severe accidents by reinforcing its capability to cope with the design basis accidents (DBA) and further with some accidents beyond DBAs caused by multiple failures, and secondly mitigate severe accidents to ensure the retention of radioactive materials in the containment by providing mean to maintain the containment integrity. For severe accident mitigation, KNGR principally takes the concept of ex-vessel corium cooling. To implement this concept, KNGR is equipped with a large cavity and cavity flooding system connected to the in-containment refueling water storage tank. Other major systems incorporated in KNGR are hydrogen igniters and safety depressurization systems. In addition, the KNGR containment is designed to withstand the pressure and temperature conditions expected during the course of severe accidents. In this paper, the design features and status of system designs related with severe accidents will be presented. Also, R and D activities related to severe accident mitigation system design will be briefly described

Tailoring next-generation biofuels and their combustion in next-generation engines

Energy Technology Data Exchange (ETDEWEB)

Gladden, John Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wu, Weihua [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Taatjes, Craig A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Scheer, Adam Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Turner, Kevin M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Yu, Eizadora T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); O' Bryan, Greg [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Powell, Amy Jo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gao, Connie W. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

2013-11-01

Increasing energy costs, the dependence on foreign oil supplies, and environmental concerns have emphasized the need to produce sustainable renewable fuels and chemicals. The strategy for producing next-generation biofuels must include efficient processes for biomass conversion to liquid fuels and the fuels must be compatible with current and future engines. Unfortunately, biofuel development generally takes place without any consideration of combustion characteristics, and combustion scientists typically measure biofuels properties without any feedback to the production design. We seek to optimize the fuel/engine system by bringing combustion performance, specifically for advanced next-generation engines, into the development of novel biosynthetic fuel pathways. Here we report an innovative coupling of combustion chemistry, from fundamentals to engine measurements, to the optimization of fuel production using metabolic engineering. We have established the necessary connections among the fundamental chemistry, engine science, and synthetic biology for fuel production, building a powerful framework for co-development of engines and biofuels.

High Throughput Line-of-Sight MIMO Systems for Next Generation Backhaul Applications

Science.gov (United States)

Song, Xiaohang; Cvetkovski, Darko; Hälsig, Tim; Rave, Wolfgang; Fettweis, Gerhard; Grass, Eckhard; Lankl, Berthold

2017-09-01

The evolution to ultra-dense next generation networks requires a massive increase in throughput and deployment flexibility. Therefore, novel wireless backhaul solutions that can support these demands are needed. In this work we present an approach for a millimeter wave line-of-sight MIMO backhaul design, targeting transmission rates in the order of 100 Gbit/s. We provide theoretical foundations for the concept showcasing its potential, which are confirmed through channel measurements. Furthermore, we provide insights into the system design with respect to antenna array setup, baseband processing, synchronization, and channel equalization. Implementation in a 60 GHz demonstrator setup proves the feasibility of the system concept for high throughput backhauling in next generation networks.

Next-Generation Tools For Next-Generation Surveys

Science.gov (United States)

Murray, S. G.

2017-04-01

The next generation of large-scale galaxy surveys, across the electromagnetic spectrum, loom on the horizon as explosively game-changing datasets, in terms of our understanding of cosmology and structure formation. We are on the brink of a torrent of data that is set to both confirm and constrain current theories to an unprecedented level, and potentially overturn many of our conceptions. One of the great challenges of this forthcoming deluge is to extract maximal scientific content from the vast array of raw data. This challenge requires not only well-understood and robust physical models, but a commensurate network of software implementations with which to efficiently apply them. The halo model, a semi-analytic treatment of cosmological spatial statistics down to nonlinear scales, provides an excellent mathematical framework for exploring the nature of dark matter. This thesis presents a next-generation toolkit based on the halo model formalism, intended to fulfil the requirements of next-generation surveys. Our toolkit comprises three tools: (i) hmf, a comprehensive and flexible calculator for halo mass functions (HMFs) within extended Press-Schechter theory, (ii) the MRP distribution for extremely efficient analytic characterisation of HMFs, and (iii) halomod, an extension of hmf which provides support for the full range of halo model components. In addition to the development and technical presentation of these tools, we apply each to the task of physical modelling. With hmf, we determine the precision of our knowledge of the HMF, due to uncertainty in our knowledge of the cosmological parameters, over the past decade of cosmic microwave background (CMB) experiments. We place rule-of-thumb uncertainties on the predicted HMF for the Planck cosmology, and find that current limits on the precision are driven by modeling uncertainties rather than those from cosmological parameters. With the MRP, we create and test a method for robustly fitting the HMF to observed

Plant availability design aspects of Korean next generation reactor

International Nuclear Information System (INIS)

Woo Sang Lim; Ha Chung Beak

1998-01-01

The purpose of this paper is to describe the KNGR design concepts adopted for reducing forced outages and refueling outages, and current design changes, to assess their availability impacts compared to existing domestic nuclear power plants, and then to identify design directions for next design stage. (author)

Advantages and Disadvantages of Physiological Assessment For Next Generation Control Room Design

Energy Technology Data Exchange (ETDEWEB)

Tuan Q. Tran; Ronald L. Boring; Donald D. Dudenhoeffer; Bruce P Hallbert; M. David Keller; Tessa M. Anderson

2007-08-01

Abstract - We propose using non-obtrusive physiological assessment (e.g., eye tracking,) to assess human information processing errors (e.g., loss of vigilance) and limitations (e.g., workload) for advanced energy systems early in the design process. This physiological approach for assessing risk will circumvent many limitations of current risk methodologies such as subjective rating (e.g., rater’s biases) and performance modeling (e.g., risk assessment is scripted and is based upon the individual modeler’s judgment). Key uses will be to evaluate (early in the design process) novel control room equipment and configurations as well as newly developed automated systems that will inevitably place a high information load on operators. The physiological risk assessment tool will allow better precision in pinpointing problematic design issues and will provide a “real-time” assessment of risk. Furthermore, this physiological approach would extend the state-of-the-art of human reliability methods from a “static” measure to more “dynamic.” This paper will discuss a broad range of the current popular online performance gauges as well as its advantages and disadvantages for use in next generation control room.

Designing Successful Next-Generation Instruments to Detect the Epoch of Reionization

Science.gov (United States)

Thyagarajan, Nithyanandan; Hydrogen Epoch of Reionization Array (HERA) team, Murchison Widefield Array (MWA) team

2018-01-01

The Epoch of Reionization (EoR) signifies a period of intense evolution of the Inter-Galactic Medium (IGM) in the early Universe caused by the first generations of stars and galaxies, wherein they turned the neutral IGM to be completely ionized by redshift ≥ 6. This important epoch is poorly explored to date. Measurement of redshifted 21 cm line from neutral Hydrogen during the EoR is promising to provide the most direct constraints of this epoch. Ongoing experiments to detect redshifted 21 cm power spectrum during reionization, including the Murchison Widefield Array (MWA), Precision Array for Probing the Epoch of Reionization (PAPER), and the Low Frequency Array (LOFAR), appear to be severely affected by bright foregrounds and unaccounted instrumental systematics. For example, the spectral structure introduced by wide-field effects, aperture shapes and angular power patterns of the antennas, electrical and geometrical reflections in the antennas and electrical paths, and antenna position errors can be major limiting factors. These mimic the 21 cm signal and severely degrade the instrument performance. It is imperative for the next-generation of experiments to eliminate these systematics at their source via robust instrument design. I will discuss a generic framework to set cosmologically motivated antenna performance specifications and design strategies using the Precision Radio Interferometry Simulator (PRISim) -- a high-precision tool that I have developed for simulations of foregrounds and the instrument transfer function intended primarily for 21 cm EoR studies, but also broadly applicable to interferometer-based intensity mapping experiments. The Hydrogen Epoch of Reionization Array (HERA), designed in-part based on this framework, is expected to detect the 21 cm signal with high significance. I will present this framework and the simulations, and their potential for designing upcoming radio instruments such as HERA and the Square Kilometre Array (SKA).

Next generation ATCA control infrastructure for the CMS Phase-2 upgrades

CERN Document Server

Smith, Wesley; Svetek, Aleš; Tikalsky, Jes; Fobes, Robert; Dasu, Sridhara; Smith, Wesley; Vicente, Marcelo

2017-01-01

A next generation control infrastructure to be used in Advanced TCA (ATCA) blades at CMS experiment is being designed and tested. Several ATCA systems are being prepared for the High-Luminosity LHC (HL-LHC) and will be installed at CMS during technical stops. The next generation control infrastructure will provide all the necessary hardware, firmware and software required in these systems, decreasing development time and increasing flexibility. The complete infrastructure includes an Intelligent Platform Management Controller (IPMC), a Module Management Controller (MMC) and an Embedded Linux Mezzanine (ELM) processing card.

Designs and Architectures for the Next Generation of Organic Solar Cells

Directory of Open Access Journals (Sweden)

Kang-Shyang Liao

2010-06-01

Full Text Available Organic solar cells show great promise as an economically and environmentally friendly technology to utilize solar energy because of their simple fabrication processes and minimal material usage. However, new innovations and breakthroughs are needed for organic solar cell technology to become competitive in the future. This article reviews research efforts and accomplishments focusing on three issues: power conversion efficiency, device stability and processability for mass production, followed by an outlook for optimizing OSC performance through device engineering and new architecture designs to realize next generation organic solar cells.

Next generation PWR

International Nuclear Information System (INIS)

Tanaka, Toshihiko; Fukuda, Toshihiko; Usui, Shuji

2001-01-01

Development of LWR for power generation in Japan has been intended to upgrade its reliability, safety, operability, maintenance and economy as well as to increase its capacity in order, since nuclear power generation for commercial use was begun on 1970, to steadily increase its generation power. And, in Japan, ABWR (advanced BWR) of the most promising LWR in the world, was already used actually and APWR (advanced PWR) with the largest output in the world is also at a step of its actual use. And, development of the APWR in Japan was begun on 1980s, and is at a step of plan on construction of its first machine at early of this century. However, by large change of social affairs, economy of nuclear power generation is extremely required, to be positioned at an APWR improved development reactor promoted by collaboration of five PWR generation companies and the Mitsubishi Electric Co., Ltd. Therefore, on its development, investigation on effect of change in social affairs on nuclear power stations was at first carried out, to establish a design requirement for the next generation PWR. Here were described on outline, reactor core design, safety concept, and safety evaluation of APWR+ and development of an innovative PWR. (G.K.)

NASA's Next Generation Space Geodesy Network

Science.gov (United States)

Desai, S. D.; Gross, R. S.; Hilliard, L.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry, J. F.; Merkowitz, S. M.; Murphy, D.; Noll, C. E.;

Next-generation phylogenomics

Directory of Open Access Journals (Sweden)

Chan Cheong Xin

2013-01-01

Full Text Available Abstract Thanks to advances in next-generation technologies, genome sequences are now being generated at breadth (e.g. across environments and depth (thousands of closely related strains, individuals or samples unimaginable only a few years ago. Phylogenomics – the study of evolutionary relationships based on comparative analysis of genome-scale data – has so far been developed as industrial-scale molecular phylogenetics, proceeding in the two classical steps: multiple alignment of homologous sequences, followed by inference of a tree (or multiple trees. However, the algorithms typically employed for these steps scale poorly with number of sequences, such that for an increasing number of problems, high-quality phylogenomic analysis is (or soon will be computationally infeasible. Moreover, next-generation data are often incomplete and error-prone, and analysis may be further complicated by genome rearrangement, gene fusion and deletion, lateral genetic transfer, and transcript variation. Here we argue that next-generation data require next-generation phylogenomics, including so-called alignment-free approaches. Reviewers Reviewed by Mr Alexander Panchin (nominated by Dr Mikhail Gelfand, Dr Eugene Koonin and Prof Peter Gogarten. For the full reviews, please go to the Reviewers’ comments section.

Next Generation Solar Collectors for CSP

Energy Technology Data Exchange (ETDEWEB)

Molnar, Attila [3M Company, St. Paul, MN (United States); Charles, Ruth [3M Company, St. Paul, MN (United States)

2014-07-31

The intent of “Next Generation Solar Collectors for CSP” program was to develop key technology elements for collectors in Phase 1 (Budget Period 1), design these elements in Phase 2 (Budget Period 2) and to deploy and test the final collector in Phase 3 (Budget Period 3). 3M and DOE mutually agreed to terminate the program at the end of Budget Period 1, primarily due to timeline issues. However, significant advancements were achieved in developing a next generation reflective material and panel that has the potential to significantly improve the efficiency of CSP systems.

Next generation toroidal devices

International Nuclear Information System (INIS)

Yoshikawa, Shoichi

1998-10-01

A general survey of the possible approach for the next generation toroidal devices was made. Either surprisingly or obviously (depending on one's view), the technical constraints along with the scientific considerations lead to a fairly limited set of systems for the most favorable approach for the next generation devices. Specifically if the magnetic field strength of 5 T or above is to be created by superconducting coils, it imposes minimum in the aspect ratio for the tokamak which is slightly higher than contemplated now for ITER design. The similar technical constraints make the minimum linear size of a stellarator large. Scientifically, it is indicated that a tokamak of 1.5 times in the linear dimension should be able to produce economically, especially if a hybrid reactor is allowed. For the next stellarator, it is strongly suggested that some kind of helical axis is necessary both for the (almost) absolute confinement of high energy particles and high stability and equilibrium beta limits. The author still favors a heliac most. Although it may not have been clearly stated in the main text, the stability afforded by the shearless layer may be exploited fully in a stellarator. (author)

Next generation toroidal devices

Energy Technology Data Exchange (ETDEWEB)

Yoshikawa, Shoichi [Princeton Plasma Physics Lab., Princeton Univ., NJ (United States)

1998-10-01

A general survey of the possible approach for the next generation toroidal devices was made. Either surprisingly or obviously (depending on one`s view), the technical constraints along with the scientific considerations lead to a fairly limited set of systems for the most favorable approach for the next generation devices. Specifically if the magnetic field strength of 5 T or above is to be created by superconducting coils, it imposes minimum in the aspect ratio for the tokamak which is slightly higher than contemplated now for ITER design. The similar technical constraints make the minimum linear size of a stellarator large. Scientifically, it is indicated that a tokamak of 1.5 times in the linear dimension should be able to produce economically, especially if a hybrid reactor is allowed. For the next stellarator, it is strongly suggested that some kind of helical axis is necessary both for the (almost) absolute confinement of high energy particles and high stability and equilibrium beta limits. The author still favors a heliac most. Although it may not have been clearly stated in the main text, the stability afforded by the shearless layer may be exploited fully in a stellarator. (author)

Materiomics for Oral Disease Diagnostics and Personal Health Monitoring: Designer Biomaterials for the Next Generation Biomarkers

Science.gov (United States)

Zhang, Wenjun; Wang, Ming L.; Khalili, Sammy

2016-01-01

Abstract We live in exciting times for a new generation of biomarkers being enabled by advances in the design and use of biomaterials for medical and clinical applications, from nano- to macro-materials, and protein to tissue. Key challenges arise, however, due to both scientific complexity and compatibility of the interface of biology and engineered materials. The linking of mechanisms across scales by using a materials science approach to provide structure–process–property relations characterizes the emerging field of ‘materiomics,’ which offers enormous promise to provide the hitherto missing tools for biomaterial development for clinical diagnostics and the next generation biomarker applications towards personal health monitoring. Put in other words, the emerging field of materiomics represents an essentially systematic approach to the investigation of biological material systems, integrating natural functions and processes with traditional materials science perspectives. Here we outline how materiomics provides a game-changing technology platform for disruptive innovation in biomaterial science to enable the design of tailored and functional biomaterials—particularly, the design and screening of DNA aptamers for targeting biomarkers related to oral diseases and oral health monitoring. Rigorous and complementary computational modeling and experimental techniques will provide an efficient means to develop new clinical technologies in silico, greatly accelerating the translation of materiomics-driven oral health diagnostics from concept to practice in the clinic. PMID:26760957

Design requirements of instrumentation and control systems for next generation reactor

International Nuclear Information System (INIS)

Koo, In Soo; Lee, Byung Sun; Park, Kwang Hyun; Park, Heu Yoon; Lee, Dong Young; Kim, Jung Taek; Hwang, In Koo; Chung, Chul Hwan; Hur, Seop; Kim, Chang Hoi; Na, Nan Ju

1994-03-01

In this report, the basic design requirements of Instrumentation and Control systems for next generation reactor are described, which are top-tier level, to support the advanced I and C systems. It contains the requirements in accordance with the plant reliability, the plant performance, the operator's aid functions, the features for maintenance and testing, licensing issues for I and C systems. Advanced I and C systems are characterized such as the application of the digital and the human engineering technologies. To development of this requirements, the I and C systems for the foreign passive and the evolutionary types of reactor and the domestic conventional reators were reviewed and anlysed. At the detail design stage, these requirements will be used for top-tier requirements. To develop the detail design requirements in the future, more quantitive and qualitive analyses are need to be added. (Author) 44 refs

Design requirements of instrumentation and control systems for next generation reactor

Energy Technology Data Exchange (ETDEWEB)

Koo, In Soo; Lee, Byung Sun; Park, Kwang Hyun; Park, Heu Yoon; Lee, Dong Young; Kim, Jung Taek; Hwang, In Koo; Chung, Chul Hwan; Hur, Seop; Kim, Chang Hoi; Na, Nan Ju [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

1994-03-01

In this report, the basic design requirements of Instrumentation and Control systems for next generation reactor are described, which are top-tier level, to support the advanced I and C systems. It contains the requirements in accordance with the plant reliability, the plant performance, the operator`s aid functions, the features for maintenance and testing, licensing issues for I and C systems. Advanced I and C systems are characterized such as the application of the digital and the human engineering technologies. To development of this requirements, the I and C systems for the foreign passive and the evolutionary types of reactor and the domestic conventional reators were reviewed and anlysed. At the detail design stage, these requirements will be used for top-tier requirements. To develop the detail design requirements in the future, more quantitive and qualitive analyses are need to be added. (Author) 44 refs.

Creating Next Generation Blended Learning Environments Using Mixed Reality, Video Games and Simulations

Science.gov (United States)

Kirkley, Sonny E.; Kirkley, Jamie R.

2005-01-01

In this article, the challenges and issues of designing next generation learning environments using current and emerging technologies are addressed. An overview of the issues is provided as well as design principles that support the design of instruction and the overall learning environment. Specific methods for creating cognitively complex,…

Development of a framework for the neutronics analysis system for next generation (3)

International Nuclear Information System (INIS)

Yokoyama, Kenji; Hirai, Yasushi; Hyoudou, Hideaki; Tatsumi, Masahiro

2010-02-01

Development of innovative analysis methods and models in fundamental studies for next-generation nuclear reactor systems is in progress. In order to efficiently and effectively reflect the latest analysis methods and models to primary design of commercial reactor and/or in-core fuel management for power reactors, a next-generation analysis system MARBLE has been developed. The next-generation analysis system provides solutions to the following requirements: (1) flexibility, extensibility and user-friendliness that can apply new methods and models rapidly and effectively for fundamental studies, (2) quantitative proof of solution accuracy and adaptive scoping range for design studies, (3) coupling analysis among different study domains for the purpose of rationalization of plant systems and improvement of reliability, (4) maintainability and reusability for system extensions for the purpose of total quality management and development efficiency. The next-generation analysis system supports many fields, such as thermal-hydraulic analysis, structure analysis, reactor physics etc., and now we are studying reactor physics analysis system for fast reactor in advance. As for reactor physics analysis methods for fast reactor, we have established the JUPITER standard analysis methods based on the past study. But, there has been a problem of extreme inefficiency due to lack of functionality in the conventional analysis system when changing analysis targets and/or modeling levels. That is why, we have developed the next-generation analysis system for reactor physics which reproduces the JUPITER standard analysis method that has been developed so far and newly realizes burnup and design analysis for fast reactor and functions for cross section adjustment. In the present study, we examined in detail the existing design and implementation of ZPPR critical experiment analysis database followed by unification of models within the framework of the next-generation analysis system by

Designing the next generation (fifth generation computers)

International Nuclear Information System (INIS)

Wallich, P.

1983-01-01

A description is given of the designs necessary to develop fifth generation computers. An analysis is offered of problems and developments in parallelism, VLSI, artificial intelligence, knowledge engineering and natural language processing. Software developments are outlined including logic programming, object-oriented programming and exploratory programming. Computer architecture is detailed including concurrent computer architecture

Big Data Perspective and Challenges in Next Generation Networks

Directory of Open Access Journals (Sweden)

Kashif Sultan

2018-06-01

Full Text Available With the development towards the next generation cellular networks, i.e., 5G, the focus has shifted towards meeting the higher data rate requirements, potential of micro cells and millimeter wave spectrum. The goals for next generation networks are very high data rates, low latency and handling of big data. The achievement of these goals definitely require newer architecture designs, upgraded technologies with possible backward support, better security algorithms and intelligent decision making capability. In this survey, we identify the opportunities which can be provided by 5G networks and discuss the underlying challenges towards implementation and realization of the goals of 5G. This survey also provides a discussion on the recent developments made towards standardization, the architectures which may be potential candidates for deployment and the energy concerns in 5G networks. Finally, the paper presents a big data perspective and the potential of machine learning for optimization and decision making in 5G networks.

Next Generation Wind Turbine

Energy Technology Data Exchange (ETDEWEB)

Cheraghi, S. Hossein [Western New England Univ., Springfield, MA (United States); Madden, Frank [FloDesign Wind Turbine Corp., Waltham, MA (United States)

2012-09-01

The goal of this collaborative effort between Western New England University's College of Engineering and FloDesign Wind Turbine (FDWT) Corporation to wok on a novel areodynamic concept that could potentially lead to the next generation of wind turbines. Analytical studies and early scale model tests of FDWT's Mixer/Ejector Wind Turbine (MEWT) concept, which exploits jet-age advanced fluid dynamics, indicate that the concept has the potential to significantly reduce the cost of electricity over conventional Horizontal Axis Wind Turbines while reducing land usage. This project involved the design, fabrication, and wind tunnel testing of components of MEWT to provide the research and engineering data necessary to validate the design iterations and optimize system performance. Based on these tests, a scale model prototype called Briza was designed, fabricated, installed and tested on a portable tower to investigate and improve the design system in real world conditions. The results of these scale prototype efforts were very promising and have contributed significantly to FDWT's ongoing development of a product scale wind turbine for deployment in multiple locations around the U.S. This research was mutually beneficial to Western New England University, FDWT, and the DOE by utilizing over 30 student interns and a number of faculty in all efforts. It brought real-world wind turbine experience into the classroom to further enhance the Green Engineering Program at WNEU. It also provided on-the-job training to many students, improving their future employment opportunities, while also providing valuable information to further advance FDWT's mixer-ejector wind turbine technology, creating opportunities for future project innovation and job creation.

On reactor type comparisons for the next generation of reactors

International Nuclear Information System (INIS)

Alesso, H.P.; Majumdar, K.C.

1991-01-01

In this paper, we present a broad comparison of studies for a selected set of parameters for different nuclear reactor types including the next generation. This serves as an overview of key parameters which provide a semi-quantitative decision basis for selecting nuclear strategies. Out of a number of advanced reactor designs of the LWR type, gas cooled type, and FBR type, currently on the drawing board, the Advanced Light Water Reactors (ALWR) seem to have some edge over other types of the next generation of reactors for the near-term application. This is based on a number of attributes related to the benefit of the vast operating experience with LWRs coupled with an estimated low risk profile, economics of scale, degree of utilization of passive systems, simplification in the plant design and layout, modular fabrication and manufacturing. 32 refs., 1 fig., 3 tabs

Next generation initiation techniques

Science.gov (United States)

Warner, Tom; Derber, John; Zupanski, Milija; Cohn, Steve; Verlinde, Hans

1993-01-01

Four-dimensional data assimilation strategies can generally be classified as either current or next generation, depending upon whether they are used operationally or not. Current-generation data-assimilation techniques are those that are presently used routinely in operational-forecasting or research applications. They can be classified into the following categories: intermittent assimilation, Newtonian relaxation, and physical initialization. It should be noted that these techniques are the subject of continued research, and their improvement will parallel the development of next generation techniques described by the other speakers. Next generation assimilation techniques are those that are under development but are not yet used operationally. Most of these procedures are derived from control theory or variational methods and primarily represent continuous assimilation approaches, in which the data and model dynamics are 'fitted' to each other in an optimal way. Another 'next generation' category is the initialization of convective-scale models. Intermittent assimilation systems use an objective analysis to combine all observations within a time window that is centered on the analysis time. Continuous first-generation assimilation systems are usually based on the Newtonian-relaxation or 'nudging' techniques. Physical initialization procedures generally involve the use of standard or nonstandard data to force some physical process in the model during an assimilation period. Under the topic of next-generation assimilation techniques, variational approaches are currently being actively developed. Variational approaches seek to minimize a cost or penalty function which measures a model's fit to observations, background fields and other imposed constraints. Alternatively, the Kalman filter technique, which is also under investigation as a data assimilation procedure for numerical weather prediction, can yield acceptable initial conditions for mesoscale models. The

Design features in Korean next generation reactor focused on performance and economic viability

International Nuclear Information System (INIS)

Lee, J.S.; Chung, M.S.; Na, J.H.; Kim, M.C.; Choi, Y.S.

2001-01-01

As of the end of Dec. 1999, Korea's total nuclear power capacity reached 13,716 MWe with 16 units in operation and 4 units under construction. In addition, as part of the national long-term R and D programme launched in 1992, the Korean Next Generation Reactor (KNGR) is being developed to meet the electricity demands in the years to come and is expected to be safer and more economically competitive than any other conventional electric power sources in Korea. The KNGR project has successfully completed its second phase and is now on the third phase. In Phase III of the KNGR design development project, KNGR aims at reinforcing the economic competitiveness while maintaining safety goals. To achieve these objectives, the design options studied and the design requirements set up in the first phase are pursued while the second phase are being reviewed. This paper summarizes such efforts for design improvement in terms of performance and economic viability along with the status of nuclear power generation in Korea, focusing on KNGR currently. (author)

Safety design criteria for the next generation Sodium-cooled fast reactors based on lessons learned from the Fukushima NPS accident

International Nuclear Information System (INIS)

Sakai, Takaaki

2012-01-01

In this presentation, architecture of the safety design criteria as requirements for SFR system and the activities on safety research works to establish safety evaluation methods for the next generation SFRs are summarized with the basis on lessons learned from the Fukushima NPS accident. Nuclear safety is a grovel issue which should be achieved by the international cooperation. In respect of the development for the next generation reactor, it is necessary to build the harmonized safety criteria and evaluation methods to establish the next level of safety

The next generation CANDU 6

International Nuclear Information System (INIS)

Hopwood, J.M.

1999-01-01

AECL's product line of CANDU 6 and CANDU 9 nuclear power plants are adapted to respond to changing market conditions, experience feedback and technological development by a continuous improvement process of design evolution. The CANDU 6 Nuclear Power Plant design is a successful family of nuclear units, with the first four units entering service in 1983, and the most recent entering service this year. A further four CANDU 6 units are under construction. Starting in 1996, a focused forward-looking development program is under way at AECL to incorporate a series of individual improvements and integrate them into the CANDU 6, leading to the evolutionary development of the next-generation enhanced CANDU 6. The CANDU 6 improvements program includes all aspects of an NPP project, including engineering tools improvements, design for improved constructability, scheduling for faster, more streamlined commissioning, and improved operating performance. This enhanced CANDU 6 product will combine the benefits of design provenness (drawing on the more than 70 reactor-years experience of the seven operating CANDU 6 units), with the advantages of an evolutionary next-generation design. Features of the enhanced CANDU 6 design include: Advanced Human Machine Interface - built around the Advanced CANDU Control Centre; Advanced fuel design - using the newly demonstrated CANFLEX fuel bundle; Improved Efficiency based on improved utilization of waste heat; Streamlined System Design - including simplifications to improve performance and safety system reliability; Advanced Engineering Tools, -- featuring linked electronic databases from 3D CADDS, equipment specification and material management; Advanced Construction Techniques - based on open top equipment installation and the use of small skid mounted modules; Options defined for Passive Heat Sink capability and low-enrichment core optimization. (author)

Tin-based anode materials with well-designed architectures for next-generation lithium-ion batteries

Science.gov (United States)

Liu, Lehao; Xie, Fan; Lyu, Jing; Zhao, Tingkai; Li, Tiehu; Choi, Bong Gill

2016-07-01

Tin (Sn) has long been considered to be a promising replacement anode material for graphite in next-generation lithium-ion batteries (LIBs), because of its attractive comprehensive advantages of high gravimetric/volumetric capacities, environmental benignity, low cost, high safety, etc. However, Sn-based anodes suffer from severe capacity fading resulting mainly from their large volume expansions/contractions during lithiation/delithiation and subsequent pulverization, coalescence, delamination from current collectors, and poor Li+/electron transport. To circumvent these issues, a number of extraordinary architectures from nanostructures to anchored, layered/sandwich, core-shell, porous and even integrated structures have been exquisitely constructed to enhance the cycling performance. To cater for the rapid development of Sn-based anodes, we summarize the advances made in structural design principles, fabrication methods, morphological features and battery performance with focus on material structures. In addition, we identify the associated challenges and problems presented by recently-developed anodes and offer suggestions and perspectives for facilitating their practical implementations in next-generation LIBs.

Implementing the Next Generation Science Standards

Science.gov (United States)

Penuel, William R.; Harris, Christopher J.; DeBarger, Angela Haydel

2015-01-01

The Next Generation Science Standards embody a new vision for science education grounded in the idea that science is both a body of knowledge and a set of linked practices for developing knowledge. The authors describe strategies that they suggest school and district leaders consider when designing strategies to support NGSS implementation.

Power Converter Control Algorithm Design and Simulation for the NREL Next-Generation Drivetrain: July 8, 2013 - January 7, 2016

Energy Technology Data Exchange (ETDEWEB)

Blodgett, Douglas [DNV KEMA Renewables, Inc., San Ramon, CA (United States); Behnke, Michael [DNV KEMA Renewables, Inc., San Ramon, CA (United States); Erdman, William [DNV KEMA Renewables, Inc., San Ramon, CA (United States)

2016-08-01

The National Renewable Energy Laboratory (NREL) and NREL Next-Generation Drivetrain Partners are developing a next-generation drivetrain (NGD) design as part of a Funding Opportunity Announcement award from the U.S. Department of Energy. The proposed NGD includes comprehensive innovations to the gearbox, generator, and power converter that increase the gearbox reliability and drivetrain capacity, while lowering deployment and operation and maintenance costs. A key task within this development effort is the power converter fault control algorithm design and associated computer simulations using an integrated electromechanical model of the drivetrain. The results of this task will be used in generating the embedded control software to be utilized in the power converter during testing of the NGD in the National Wind Technology Center 2.5-MW dynamometer. A list of issues to be addressed with these algorithms was developed by review of the grid interconnection requirements of various North American transmission system operators, and those requirements that presented the greatest impact to the wind turbine drivetrain design were then selected for mitigation via power converter control algorithms.

The next generation of power reactors - safety characteristics

International Nuclear Information System (INIS)

Modro, S.M.

1995-01-01

The next generation of commercial nuclear power reactors is characterized by a new approach to achieving reliability of their safety systems. In contrast to current generation reactors, these designs apply passive safety features that rely on gravity-driven transfer processes or stored energy, such as gas-pressurized accumulators or electric batteries. This paper discusses the passive safety system of the AP600 and Simplified Boiling Water Reactor (SBWR) designs

A Systems Engineering Framework for Design, Construction and Operation of the Next Generation Nuclear Plant

International Nuclear Information System (INIS)

Edward J. Gorski; Charles V. Park; Finis H. Southworth

2004-01-01

Not since the International Space Station has a project of such wide participation been proposed for the United States. Ten countries, the European Union, universities, Department of Energy (DOE) laboratories, and industry will participate in the research and development, design, construction and/or operation of the fourth generation of nuclear power plants with a demonstration reactor to be built at a DOE site and operational by the middle of the next decade. This reactor will be like no other. The Next Generation Nuclear Plant (NGNP) will be passively safe, economical, highly efficient, modular, proliferation resistant, and sustainable. In addition to electrical generation, the NGNP will demonstrate efficient and cost effective generation of hydrogen to support the President's Hydrogen Initiative. To effectively manage this multi-organizational and technologically complex project, systems engineering techniques and processes will be used extensively to ensure delivery of the final product. The technological and organizational challenges are complex. Research and development activities are required, material standards require development, hydrogen production, storage and infrastructure requirements are not well developed, and the Nuclear Regulatory Commission may further define risk-informed/performance-based approach to licensing. Detailed design and development will be challenged by the vast cultural and institutional differences across the participants. Systems engineering processes must bring the technological and organizational complexity together to ensure successful product delivery. This paper will define the framework for application of systems engineering to this $1.5B - $1.9B project

SQoS as the Base for Next Generation Global Infrastructure

DEFF Research Database (Denmark)

Madsen, Ole Brun; Knudsen, Thomas Phillip; Pedersen, Jens Myrup

2003-01-01

The convergence towards a unified global WAN platform, providing both best effort services and guaranteed high quality services, sets the agenda for the design and implementation of the next generation global information infrastructure. The absence of design principles, allowing for smooth and cost...... efficient scalability without loss of control over the structurally based properties may prevent or seriously delay the introduction of globally available new application and switching services. Reliability and scalability issues are addressed from a structural viewpoint. The concept of Structural Quality...

SQoS as the Base for Next Generation Global Infrastructure

DEFF Research Database (Denmark)

Madsen, Ole Brun; Knudsen, Thomas Phillip; Pedersen, Jens Myrup

The convergence towards a unified global WAN platform, providing both best effort services and guaranteed high quality services, sets the agenda for the design and implementation of the next generation global information infrastructure. The absence of design principles, allowing for smooth and cost...... efficient scalability without loss of control over the structurally based properties may prevent or seriously delay the introduction of globally available new application and switching services.Reliability and scalability issues are addressed from a structural viewpoint. The concept of Structural Quality...

Galaxy LIMS for next-generation sequencing

NARCIS (Netherlands)

Scholtalbers, J.; Rossler, J.; Sorn, P.; Graaf, J. de; Boisguerin, V.; Castle, J.; Sahin, U.

2013-01-01

SUMMARY: We have developed a laboratory information management system (LIMS) for a next-generation sequencing (NGS) laboratory within the existing Galaxy platform. The system provides lab technicians standard and customizable sample information forms, barcoded submission forms, tracking of input

Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics.

Science.gov (United States)

Shah, Dhaval K

2015-10-01

Increasingly sophisticated protein engineering efforts have been undertaken lately to generate protein therapeutics with desired properties. This has resulted in the discovery of the next generation of protein therapeutics, which include: engineered antibodies, immunoconjugates, bi/multi-specific proteins, antibody mimetic novel scaffolds, and engineered ligands/receptors. These novel protein therapeutics possess unique physicochemical properties and act via a unique mechanism-of-action, which collectively makes their pharmacokinetics (PK) and pharmacodynamics (PD) different than other established biological molecules. Consequently, in order to support the discovery and development of these next generation molecules, it becomes important to understand the determinants controlling their PK/PD. This review discusses the determinants that a PK/PD scientist should consider during the design and development of next generation protein therapeutics. In addition, the role of systems PK/PD models in enabling rational development of the next generation protein therapeutics is emphasized.

The NASA Next Generation Stirling Technology Program Overview

Science.gov (United States)

Schreiber, J. G.; Shaltens, R. K.; Wong, W. A.

2005-12-01

NASAs Science Mission Directorate is developing the next generation Stirling technology for future Radioisotope Power Systems (RPS) for surface and deep space missions. The next generation Stirling convertor is one of two advanced power conversion technologies currently being developed for future NASA missions, and is capable of operating for both planetary atmospheres and deep space environments. The Stirling convertor (free-piston engine integrated with a linear alternator) produces about 90 We(ac) and has a specific power of about 90 We/kg. Operating conditions of Thot at 850 degree C and Trej at 90 degree C results in the Stirling convertor estimated efficiency of about 40 per cent. Using the next generation Stirling convertor in future RPS, the "system" specific power is estimated at 8 We/kg. The design lifetime is three years on the surface of Mars and fourteen years in deep space missions. Electrical power of about 160 We (BOM) is produced by two (2) free-piston Stirling convertors heated by two (2) General Purpose Heat Source (GPHS) modules. This development is being performed by Sunpower, Athens, OH with Pratt & Whitney, Rocketdyne, Canoga Park, CA under contract to Glenn Research Center (GRC), Cleveland, Ohio. GRC is guiding the independent testing and technology development for the next generation Stirling generator.

ATHENA: system design and implementation for a next generation x-ray telescope

Science.gov (United States)

Ayre, M.; Bavdaz, M.; Ferreira, I.; Wille, E.; Lumb, D.; Linder, M.

2015-08-01

ATHENA, Europe's next generation x-ray telescope, has recently been selected for the 'L2' slot in ESA's Cosmic Vision Programme, with a mandate to address the 'Hot and Energetic Universe' Cosmic Vision science theme. The mission is currently in the Assessment/Definition Phase (A/B1), with a view to formal adoption after a successful System Requirements Review in 2019. This paper will describe the reference mission architecture and spacecraft design produced during Phase 0 by the ESA Concurrent Design Facility (CDF), in response to the technical requirements and programmatic boundary conditions. The main technical requirements and their mapping to resulting design choices will be presented, at both mission and spacecraft level. An overview of the spacecraft design down to subsystem level will then be presented (including the telescope and instruments), remarking on the critically-enabling technologies where appropriate. Finally, a programmatic overview will be given of the on-going Assessment Phase, and a snapshot of the prospects for securing the `as-proposed' mission within the cost envelope will be given.

Areva's water chemistry guidebook with chemistry guidelines for next generation plants (AREVA EPRTM reactors)

International Nuclear Information System (INIS)

Ryckelynck, N.; Chahma, F.; Caris, N.; Guillermier, P.; Brun, C.; Caron-Charles, M.; Lamanna, L.; Fandrich, J.; Jaeggy, M.; Stellwag, B.

2012-09-01

Over the years, AREVA globally has maintained a strong expertise in LWR water chemistry and has been focused on minimizing short-term and long-term detrimental effects of chemistry for startup, operation and shutdown chemistry for all key plant components (material integrity and reliability, promote optimal thermal performances, etc.) and fuel. Also AREVA is focused on minimizing contamination and equipment/plant dose rates. Current Industry Guidelines (EPRI, VGB, etc.) provide utilities with selected chemistry guidance for the current operating fleet. With the next generation of PWR plants (e.g. AREVA's EPR TM reactor), materials of construction and design have been optimized based on industry lessons learned over the last 50+ years. To support the next generation design, AREVA water chemistry experts, have subsequently developed a Chemistry Guidebook with chemistry guidelines based on an analysis of the current international practices, plant operating experience, R and D data and calculation codes now available and/or developed by AREVA. The AREVA LWR chemistry Guidebook can be used to help resolve utility and safety authority questions and addresses regulation requirement questions/issues for next generation plants. The Chemistry Guidebook provides water chemistry guidelines for primary coolant, secondary side circuit and auxiliary systems during startup, normal operation and shutdown conditions. It also includes conditioning and impurity limits, along with monitoring locations and frequency requirements. The Chemistry Guidebook Guidelines will be used as a design reference for AREVA's next generation plants (e.g. EPR TM reactor). (authors)

The Next-Generation U.S. Retail Electricity Market with Customers and Prosumers—A Bibliographical Survey

Directory of Open Access Journals (Sweden)

Tao Chen

2017-12-01

Full Text Available Due to the rapidly-changing technologies in the power industry, many new references addressing the frameworks and business models of the next-generation retail electricity market are entering the research community. In particular, considering new customers with considerable demand response awareness and so-called prosumers with localized power generation based on distributed energy resources (DERs, the next-generation retail electricity market infrastructure will be a level playing field for local energy transactions, strategic pricing scheme design, new business model design and building an innovative energy ecosystem. Consequently, there is an urgent need to keep track of international experiences and activities taking place in the field of the market mechanism design problem at the distribution level. This paper provides a comprehensive survey of recent technology developments and aims to inspire awareness of the further deregulation of the electricity market, especially in areas close to customers. We mainly bring attention to the more than 90 articles published during the past five years. The collected literature has been divided into different sections to discuss different aspects of the next-generation retail electricity market under the deregulated power industry.

Optimizing the next generation optical access networks

DEFF Research Database (Denmark)

Amaya Fernández, Ferney Orlando; Soto, Ana Cardenas; Tafur Monroy, Idelfonso

2009-01-01

Several issues in the design and optimization of the next generation optical access network (NG-OAN) are presented. The noise, the distortion and the fiber optic nonlinearities are considered to optimize the video distribution link in a passive optical network (PON). A discussion of the effect...

Next Generation Nuclear Plant Pre-Conceptual Design Report

International Nuclear Information System (INIS)

Larry Demick; Doug Vandel

2007-01-01

The Next Generation Nuclear Plant (NGNP) will be a demonstration of the technical, licensing, operational, and commercial viability of High Temperature Gas-Cooled Reactor (HTGR) technology for the production of process heat, electricity, and hydrogen. This nuclear based technology can provide high-temperature process heat (up to 950 C) that can be used as a substitute for the burning of fossil fuels for a wide range of commercial applications. The substitution of the HTGR for burning fossil fuels conserves these hydrocarbon resources for other uses, reduces uncertainty in the cost and supply of natural gas and oil, and eliminates the emissions of greenhouse gases attendant with the burning of these fuels. The HTGR is a passively1 safe nuclear reactor concept with an easily understood safety basis that permits substantially reduced emergency planning requirements and improved siting flexibility compared to current and advanced light water reactors (LWRs). In the Energy Policy Act of 2005 (EPAct), the Department of Energy (DOE) was tasked with providing a demonstration of this HTGR technology to economically and reliably produce electricity and hydrogen by the year 2021. As the lead nuclear technology development laboratory of the DOE, the Idaho National Laboratory (INL) has initiated the work necessary to complete this task. The EPAct also stipulated that the task should be undertaken in partnership with the industrial end users of the technology. To that end, a working group has been assembled consisting of suppliers of the technology, nuclear plant owner/operators, other supportive technology companies, and potential end users. The objective of the working group is to form an Alliance that would provide the private sector perspective and direction for completion of the NGNP in partnership with the DOE. The Alliance will support the selection of the specific operating conditions and configuration for NGNP to ensure it meets private sector expectations, commence

The whiteStar development project: Westinghouse's next generation core design simulator and core monitoring software to power the nuclear renaissance

International Nuclear Information System (INIS)

Boyd, W. A.; Mayhue, L. T.; Penkrot, V. S.; Zhang, B.

2009-01-01

The WhiteStar project has undertaken the development of the next generation core analysis and monitoring system for Westinghouse Electric Company. This on-going project focuses on the development of the ANC core simulator, BEACON core monitoring system and NEXUS nuclear data generation system. This system contains many functional upgrades to the ANC core simulator and BEACON core monitoring products as well as the release of the NEXUS family of codes. The NEXUS family of codes is an automated once-through cross section generation system designed for use in both PWR and BWR applications. ANC is a multi-dimensional nodal code for all nuclear core design calculations at a given condition. ANC predicts core reactivity, assembly power, rod power, detector thimble flux, and other relevant core characteristics. BEACON is an advanced core monitoring and support system which uses existing instrumentation data in conjunction with an analytical methodology for on-line generation and evaluation of 3D core power distributions. This new system is needed to design and monitor the Westinghouse AP1000 PWR. This paper describes provides an overview of the software system, software development methodologies used as well some initial results. (authors)

Next-Generation Sequencing Platforms

Science.gov (United States)

Mardis, Elaine R.

2013-06-01

Automated DNA sequencing instruments embody an elegant interplay among chemistry, engineering, software, and molecular biology and have built upon Sanger's founding discovery of dideoxynucleotide sequencing to perform once-unfathomable tasks. Combined with innovative physical mapping approaches that helped to establish long-range relationships between cloned stretches of genomic DNA, fluorescent DNA sequencers produced reference genome sequences for model organisms and for the reference human genome. New types of sequencing instruments that permit amazing acceleration of data-collection rates for DNA sequencing have been developed. The ability to generate genome-scale data sets is now transforming the nature of biological inquiry. Here, I provide an historical perspective of the field, focusing on the fundamental developments that predated the advent of next-generation sequencing instruments and providing information about how these instruments work, their application to biological research, and the newest types of sequencers that can extract data from single DNA molecules.

Next-generation fiber lasers enabled by high-performance components

Science.gov (United States)

Kliner, D. A. V.; Victor, B.; Rivera, C.; Fanning, G.; Balsley, D.; Farrow, R. L.; Kennedy, K.; Hampton, S.; Hawke, R.; Soukup, E.; Reynolds, M.; Hodges, A.; Emery, J.; Brown, A.; Almonte, K.; Nelson, M.; Foley, B.; Dawson, D.; Hemenway, D. M.; Urbanek, W.; DeVito, M.; Bao, L.; Koponen, J.; Gross, K.

2018-02-01

Next-generation industrial fiber lasers enable challenging applications that cannot be addressed with legacy fiber lasers. Key features of next-generation fiber lasers include robust back-reflection protection, high power stability, wide power tunability, high-speed modulation and waveform generation, and facile field serviceability. These capabilities are enabled by high-performance components, particularly pump diodes and optical fibers, and by advanced fiber laser designs. We summarize the performance and reliability of nLIGHT diodes, fibers, and next-generation industrial fiber lasers at power levels of 500 W - 8 kW. We show back-reflection studies with up to 1 kW of back-reflected power, power-stability measurements in cw and modulated operation exhibiting sub-1% stability over a 5 - 100% power range, and high-speed modulation (100 kHz) and waveform generation with a bandwidth 20x higher than standard fiber lasers. We show results from representative applications, including cutting and welding of highly reflective metals (Cu and Al) for production of Li-ion battery modules and processing of carbon fiber reinforced polymers.

Final design and progress of WEAVE : the next generation wide-field spectroscopy facility for the William Herschel Telescope

NARCIS (Netherlands)

Dalton, Gavin; Trager, Scott; Abrams, Don Carlos; Bonifacio, Piercarlo; Aguerri, J. Alfonso L.; Middleton, Kevin; Benn, Chris; Dee, Kevin; Sayède, Frédéric; Lewis, Ian; Pragt, Johannes; Pico, Sergio; Walton, Nic; Rey, Jeurg; Allende Prieto, Carlos; Peñate, José; Lhome, Emilie; Agócs, Tibor; Alonso, José; Terrett, David; Brock, Matthew; Gilbert, James; Schallig, Ellen; Ridings, Andy; Guinouard, Isabelle; Verheijen, Marc; Tosh, Ian; Rogers, Kevin; Lee, Martin; Steele, Iain; Stuik, Remko; Tromp, Niels; Jaskó, Attila; Carrasco, Esperanza; Farcas, Szigfrid; Kragt, Jan; Lesman, Dirk; Kroes, Gabby; Mottram, Chris; Bates, Stuart; Rodriguez, Luis Fernando; Gribbin, Frank; Delgado, José Miguel; Herreros, José Miguel; Martin, Carlos; Cano, Diego; Navarro, Ramon; Irwin, Mike; Lewis, Jim; Gonzalez Solares, Eduardo; Murphy, David; Worley, Clare; Bassom, Richard; O'Mahoney, Neil; Bianco, Andrea; Zurita, Christina; ter Horst, Rik; Molinari, Emilio; Lodi, Marcello; Guerra, José; Martin, Adrian; Vallenari, Antonella; Salasnich, Bernardo; Baruffolo, Andrea; Jin, Shoko; Hill, Vanessa; Smith, Dan; Drew, Janet; Poggianti, Bianca; Pieri, Mat; Dominquez Palmero, Lillian; Farina, Cecilia

2016-01-01

We present the Final Design of the WEAVE next-generation spectroscopy facility for the William Herschel Telescope (WHT), together with a status update on the details of manufacturing, integration and the overall project schedule now that all the major fabrication contracts are in place. We also

Final design and progress of WEAVE: the next generation wide-field spectroscopy facility for the William Herschel Telescope

NARCIS (Netherlands)

Dalton, Gavin; Trager, Scott; Abrams, Don Carlos; Bonifacio, Piercarlo; Aguerri, J. Alfonso L.; Middleton, Kevin; Benn, Chris; Dee, Kevin; Sayède, Frédéric; Lewis, Ian; Pragt, Johannes; Pico, Sergio; Walton, Nic; Rey, Jeurg; Allende Prieto, Carlos; Peñate, José; Lhome, Emilie; Agócs, Tibor; Alonso, José; Terrett, David; Brock, Matthew; Gilbert, James; Schallig, Ellen; Ridings, Andy; Guinouard, Isabelle; Verheijen, Marc; Tosh, Ian; Rogers, Kevin; Lee, Martin; Steele, Iain; Stuik, Remko; Tromp, Niels; Jaskó, Attila; Carrasco, Esperanza; Farcas, Szigfrid; Kragt, Jan; Lesman, Dirk; Kroes, Gabby; Mottram, Chris; Bates, Stuart; Rodriguez, Luis Fernando; Gribbin, Frank; Delgado, José Miguel; Herreros, José Miguel; Martin, Carlos; Cano, Diego; Navarro, Ramon; Irwin, Mike; Lewis, Jim; Gonzalez Solares, Eduardo; Murphy, David; Worley, Clare; Bassom, Richard; O'Mahoney, Neil; Bianco, Andrea; Zurita, Christina; ter Horst, Rik; Molinari, Emilio; Lodi, Marcello; Guerra, José; Martin, Adrian; Vallenari, Antonella; Salasnich, Bernardo; Baruffolo, Andrea; Jin, Shoko; Hill, Vanessa; Smith, Dan; Drew, Janet; Poggianti, Bianca; Pieri, Mat; Dominquez Palmero, Lillian; Farina, Cecilia

2016-01-01

We present the Final Design of the WEAVE next-generation spectroscopy facility for the William Herschel Telescope (WHT), together with a status update on the details of manufacturing, integration and the overall project schedule now that all the major fabrication contracts are in place. We also

Neutronics activities for next generation devices

International Nuclear Information System (INIS)

Gohar, Y.

1985-01-01

Neutronic activities for the next generation devices are the subject of this paper. The main activities include TFCX and FPD blanket/shield studies, neutronic aspects of ETR/INTOR critical issues, and neutronics computational modules for the tokamak system code and tandem mirror reactor system code. Trade-off analyses, optimization studies, design problem investigations and computational models development for reactor parametric studies carried out for these activities are summarized

Energy and luminosity requirements for the next generation of linear colliders

International Nuclear Information System (INIS)

Amaldi, U.

1987-01-01

In order to gain new knowledge ('new physics') from 'next generation' linear colliders energy and luminosity are important variables when considering the design of these new elementary particle probes. The standard model of the electroweak interaction is reviewed and stipulations for postulated Higgs particle, a new neutral Z particle, and a new quark and a neutral lepton searches with next generation colliders are given

Perspectives on the development of next generation reactor systems safety analysis codes

International Nuclear Information System (INIS)

Zhang, H.

2015-01-01

'Full text:' Existing reactor system analysis codes, such as RELAP5-3D and TRAC, have gained worldwide success in supporting reactor safety analyses, as well as design and licensing of new reactors. These codes are important assets to the nuclear engineering research community, as well as to the nuclear industry. However, most of these codes were originally developed during the 1970s', and it becomes necessary to develop next-generation reactor system analysis codes for several reasons. Firstly, as new reactor designs emerge, there are new challenges emerging in numerical simulations of reactor systems such as long lasting transients and multi-physics phenomena. These new requirements are beyond the range of applicability of the existing system analysis codes. Advanced modeling and numerical methods must be taken into consideration to improve the existing capabilities. Secondly, by developing next-generation reactor system analysis codes, the knowledge (know how) in two phase flow modeling and the highly complex constitutive models will be transferred to the young generation of nuclear engineers. And thirdly, all computer codes have limited shelf life. It becomes less and less cost-effective to maintain a legacy code, due to the fast change of computer hardware and software environment. There are several critical perspectives in terms of developing next-generation reactor system analysis codes: 1) The success of the next-generation codes must be built upon the success of the existing codes. The knowledge of the existing codes, not just simply the manuals and codes, but knowing why and how, must be transferred to the next-generation codes. The next-generation codes should encompass the capability of the existing codes. The shortcomings of existing codes should be identified, understood, and properly categorized, for example into model deficiencies or numerical method deficiencies. 2) State-of-the-art models and numerical methods must be considered to

Perspectives on the development of next generation reactor systems safety analysis codes

Energy Technology Data Exchange (ETDEWEB)

Zhang, H., E-mail: Hongbin.Zhang@inl.gov [Idaho National Laboratory, Idaho Falls, ID (United States)

2015-07-01

'Full text:' Existing reactor system analysis codes, such as RELAP5-3D and TRAC, have gained worldwide success in supporting reactor safety analyses, as well as design and licensing of new reactors. These codes are important assets to the nuclear engineering research community, as well as to the nuclear industry. However, most of these codes were originally developed during the 1970s', and it becomes necessary to develop next-generation reactor system analysis codes for several reasons. Firstly, as new reactor designs emerge, there are new challenges emerging in numerical simulations of reactor systems such as long lasting transients and multi-physics phenomena. These new requirements are beyond the range of applicability of the existing system analysis codes. Advanced modeling and numerical methods must be taken into consideration to improve the existing capabilities. Secondly, by developing next-generation reactor system analysis codes, the knowledge (know how) in two phase flow modeling and the highly complex constitutive models will be transferred to the young generation of nuclear engineers. And thirdly, all computer codes have limited shelf life. It becomes less and less cost-effective to maintain a legacy code, due to the fast change of computer hardware and software environment. There are several critical perspectives in terms of developing next-generation reactor system analysis codes: 1) The success of the next-generation codes must be built upon the success of the existing codes. The knowledge of the existing codes, not just simply the manuals and codes, but knowing why and how, must be transferred to the next-generation codes. The next-generation codes should encompass the capability of the existing codes. The shortcomings of existing codes should be identified, understood, and properly categorized, for example into model deficiencies or numerical method deficiencies. 2) State-of-the-art models and numerical methods must be considered to

Generation Next

Science.gov (United States)

Hawkins, B. Denise

2010-01-01

There is a shortage of accounting professors with Ph.D.s who can prepare the next generation. To help reverse the faculty deficit, the American Institute of Certified Public Accountants (CPAs) has created the new Accounting Doctoral Scholars program by pooling more than $17 million and soliciting commitments from more than 70 of the nation's…

Next generation sensors and systems

CERN Document Server

2016-01-01

Written by experts in their area of research, this book has outlined the current status of the fundamentals and analytical concepts, modelling and design issues, technical details and practical applications of different types of sensors and discussed about the trends of next generation of sensors and systems happening in the area of Sensing technology. This book will be useful as a reference book for engineers and scientist especially the post-graduate students find will this book as reference book for their research on wearable sensors, devices and technologies.  .

Next Generation Microshutter Arrays Project

Data.gov (United States)

National Aeronautics and Space Administration — We propose to develop the next generation MicroShutter Array (MSA) as a multi-object field selector for missions anticipated in the next two decades. For many...

Project control - the next generation

International Nuclear Information System (INIS)

Iorii, V.F.; McKinnon, B.L.

1993-01-01

The Yucca Mountain Site Characterization Project (YMP) is the U.S. Department of Energy's (DOE) second largest Major System Acquisition Project. We have developed an integrated planning and control system (called PACS) that we believe represents the 'Next Generation' in project control. PACS integrates technical scope, cost, and schedule information for over 50 participating organizations and produces performances measurement reports for science and engineering managers at all levels. Our 'Next Generation' project control too, PACS, has been found to be in compliance with the new DOE Project Control System Guidelines. Additionally, the nuclear utility oversight group of the Edison Electric Institute has suggested PACS be used as a model for other civilian radioactive waste management projects. A 'Next Generation' project control tool will be necessary to do science in the 21st century

Manfacturers, service providers gear up for the next Big Thing IPV6

CERN Multimedia

2003-01-01

"IPv6 apparently is the heir apparent to the current communication standard, IPv4, and communications equipment manufacturers are taking this into consideration as they design their next-generation gear" (1/2 page).

Mobility Models for Next Generation Wireless Networks Ad Hoc, Vehicular and Mesh Networks

CERN Document Server

Santi, Paolo

2012-01-01

Mobility Models for Next Generation Wireless Networks: Ad Hoc, Vehicular and Mesh Networks provides the reader with an overview of mobility modelling, encompassing both theoretical and practical aspects related to the challenging mobility modelling task. It also: Provides up-to-date coverage of mobility models for next generation wireless networksOffers an in-depth discussion of the most representative mobility models for major next generation wireless network application scenarios, including WLAN/mesh networks, vehicular networks, wireless sensor networks, and

Advanced in-vessel retention design for next generation risk management

Energy Technology Data Exchange (ETDEWEB)

Suh, Kune Y; Hwang, Il Soon [Seoul National University, Seoul (Korea, Republic of)

1998-12-31

In the TMI-2 accident, approximately twenty (20) tons of molten core material drained into the lower plenum. Early advanced light water reactor (LWR) designs assumed a lower head failure and incorporated various measures for ex-vessel accident mitigation. However,one of the major findings from the TMI-2 Vessel Investigation Project was that one part of the reactor lower head wall estimated to have attained a temperature of 1100 deg C for about 30 minutes has seemingly experienced a comparatively rapid cooldown with no major threat to the vessel integrity. In this regard, recent empirical and analytical studies have shifted interests to such in-vessel retention designs or strategies as reactor cavity flooding, in-vessel flooding and engineered gap cooling of the vessel. Accurate thermohydrodynamic and creep deformation modeling and rupture prediction are the key to the success in developing practically useful in-vessel accident/risk management strategies. As an advanced in-vessel design concept, this work presents the COrium Attack Syndrome Immunization Structures (COASIS) that are being developed as prospective in-vessel retention devices for a next-generation LWR in concert with existing ex-vessel management measures. Both the engineered gap structures in-vessel (COASISI) and ex-vessel (COASISO) are demonstrated to maintain effective heat transfer geometry during molten core debris attack when applied to the Korean Standard Nuclear Power Plant (KSNPP) reactor. The likelihood of lower head creep rupture during a severe accident is found to be significantly suppressed by the COASIS options. 15 refs., 5 figs., 1 tab. (Author)

Advanced in-vessel retention design for next generation risk management

Energy Technology Data Exchange (ETDEWEB)

Suh, Kune Y.; Hwang, Il Soon [Seoul National University, Seoul (Korea, Republic of)

1997-12-31

In the TMI-2 accident, approximately twenty (20) tons of molten core material drained into the lower plenum. Early advanced light water reactor (LWR) designs assumed a lower head failure and incorporated various measures for ex-vessel accident mitigation. However,one of the major findings from the TMI-2 Vessel Investigation Project was that one part of the reactor lower head wall estimated to have attained a temperature of 1100 deg C for about 30 minutes has seemingly experienced a comparatively rapid cooldown with no major threat to the vessel integrity. In this regard, recent empirical and analytical studies have shifted interests to such in-vessel retention designs or strategies as reactor cavity flooding, in-vessel flooding and engineered gap cooling of the vessel. Accurate thermohydrodynamic and creep deformation modeling and rupture prediction are the key to the success in developing practically useful in-vessel accident/risk management strategies. As an advanced in-vessel design concept, this work presents the COrium Attack Syndrome Immunization Structures (COASIS) that are being developed as prospective in-vessel retention devices for a next-generation LWR in concert with existing ex-vessel management measures. Both the engineered gap structures in-vessel (COASISI) and ex-vessel (COASISO) are demonstrated to maintain effective heat transfer geometry during molten core debris attack when applied to the Korean Standard Nuclear Power Plant (KSNPP) reactor. The likelihood of lower head creep rupture during a severe accident is found to be significantly suppressed by the COASIS options. 15 refs., 5 figs., 1 tab. (Author)

The proposed human factors engineering program plan for man-machine interface system design of the next generation NPP in Korea

International Nuclear Information System (INIS)

Oh, I.S.; Lee, H.C.; Seo, S.M.; Cheon, S.W.; Park, K.O.; Lee, J.W.; Sim, B.S.

1994-01-01

Human factors application to nuclear power plant (NPP) design, especially, to man-machine interface system (MMIS) design becomes an important issue among the licensing requirements. Recently, the nuclear regulatory bodies require the evidence of systematic human factors application to the MMIS design. Human Factors Engineering Program Plan (HFEPP), as a basis and central one among the human factors application by the MMIS designers. This paper describes the framework of HFEPP for the MMIS design of next generation NPP (NG-NPP) in Korea. This framework provides an integral plan and some bases of the systematic application of human factors to the MMIS design, and consists of purpose and scope, codes and standards, human factors organization, human factors tasks, engineering control methodology, human factors documentations, and milestones. The proposed HFEPP is a top level document to define and describe human factors tasks, based on each step of MMIS design process, in view point of how, what, when and by whom to be performed. (author). 11 refs, 1 fig

Safeguards and security by design support for the next generation nuclear plant project - Progress in safeguards by design (SBD) by the United States National Nuclear Security Administration (NNSA)

International Nuclear Information System (INIS)

Bjornard, T.; Casey Durst, P.

2013-01-01

The Next Generation Nuclear Plant (NGNP) project was authorized by the United States Energy Policy Act of 2005 with the principal objective of designing, licensing, and building a Generation IV nuclear plant capable of producing both high-temperature process heat and electricity. The two candidate NGNP reactor concepts are pebble- and prismatic-fueled high-temperature gas reactors that will be licensed by the U.S. Nuclear Regulatory Commission (NRC). The conceptual design phase of the project was completed in December 2010. This paper summarizes support provided to the NGNP project to facilitate consideration of international safeguards during the design phase, or safeguards by design (SBD). Additional support was provided for domestic safeguards (material control and accounting) and physical protection, or safeguards and security by design (2SBD). The main focus of this paper is on SBD and international safeguards. Included is an overview of the international safeguards guidance contained in guidance reports for SBD. These reports contain guidance and suggestions intended to be useful to the industry design teams, but they do not contain ready-made solutions. Early and frequent interaction of design stakeholders with the International Atomic Energy Agency and the NRC are essential to a successful endeavor. The paper is followed by the slides of the presentation. (author)

Modeling the video distribution link in the Next Generation Optical Access Networks

International Nuclear Information System (INIS)

Amaya, F; Cardenas, A; Tafur, I

2011-01-01

In this work we present a model for the design and optimization of the video distribution link in the next generation optical access network. We analyze the video distribution performance in a SCM-WDM link, including the noise, the distortion and the fiber optic nonlinearities. Additionally, we consider in the model the effect of distributed Raman amplification, used to extent the capacity and the reach of the optical link. In the model, we use the nonlinear Schroedinger equation with the purpose to obtain capacity limitations and design constrains of the next generation optical access networks.

Compact 2100 nm laser diode module for next-generation DIRCM

Science.gov (United States)

Dvinelis, Edgaras; Greibus, Mindaugas; TrinkÅ«nas, Augustinas; NaujokaitÄ--, Greta; Vizbaras, Augustinas; Vizbaras, Dominykas; Vizbaras, Kristijonas

2017-10-01

Compact high-power 2100 nm laser diode module for next-generation directional infrared countermeasure (DIRCM) systems is presented. Next-generation DIRCM systems require compact, light-weight and robust laser modules which could provide intense IR light emission capable of disrupting the tracking sensor of heat-seeking missile. Currently used solid-state and fiber laser solutions for mid-IR band are bulky and heavy making them difficult to implement in smaller form-factor DIRCM systems. Recent development of GaSb laser diode technology greatly improved optical output powers and efficiencies of laser diodes working in 1900 - 2450 nm band [1] while also maintaining very attractive size, weight, power consumption and cost characteristics. 2100 nm laser diode module presented in this work performance is based on high-efficiency broad emitting area GaSb laser diode technology. Each laser diode emitter is able to provide 1 W of CW output optical power with working point efficiency up to 20% at temperature of 20 °C. For output beam collimation custom designed fast-axis collimator and slow-axis collimator lenses were used. These lenses were actively aligned and attached using UV epoxy curing. Total 2 emitters stacked vertically were used in 2100 nm laser diode module. Final optical output power of the module goes up to 2 W at temperature of 20 °C. Total dimensions of the laser diode module are 35 x 25 x 16 mm (L x W x H) with a weight of 28 grams. Finally output beam is bore-sighted to mechanical axes of the module housing allowing for easy integration into next-generation DIRCM systems.

The Quest for Rare Variants: Pooled Multiplexed Next Generation Sequencing in Plants

Directory of Open Access Journals (Sweden)

Fabio eMarroni

2012-06-01

Full Text Available Next generation sequencing (NGS instruments produce an unprecedented amount of sequence data at contained costs. This gives researchers the possibility of designing studies with adequate power to identify rare variants at a fraction of the economic and labor resources required by individual Sanger sequencing. As of today, only three research groups working in plant sciences have exploited this potentiality. They showed that pooled NGS can provide results in excellent agreement with those obtained by individual Sanger sequencing. Aim of this review is to convey to the reader the general ideas underlying the use of pooled NGS for the identification of rare variants. To facilitate a thorough understanding of the possibilities of the method we will explain in detail the variations in study design and discuss their advantages and disadvantages. We will show that information on allele frequency obtained by pooled next generation sequencing can be used to accurately compute basic population genetics indexes such as allele frequency, nucleotide diversity and Tajima’s D. Finally we will discuss applications and future perspectives of the multiplexed NGS approach.

Thermal management of next-generation contact-cooled synchrotron x-ray mirrors

Energy Technology Data Exchange (ETDEWEB)

Khounsary, A.

1999-10-29

In the past decade, several third-generation synchrotrons x-ray sources have been constructed and commissioned around the world. Many of the major problems in the development and design of the optical components capable of handling the extremely high heat loads of the generated x-ray beams have been resolved. It is expected, however, that in the next few years even more powerful x-ray beams will be produced at these facilities, for example, by increasing the particle beam current. In this paper, the design of a next generation of synchrotron x-ray mirrors is discussed. The author shows that the design of contact-cooled mirrors capable of handing x-ray beam heat fluxes in excess of 500 W/mm{sup 2} - or more than three times the present level - is well within reach, and the limiting factor is the thermal stress rather then thermally induced slope error.

Planning Instruction to Meet the Intent of the Next Generation Science Standards

Science.gov (United States)

Krajcik, Joseph; Codere, Susan; Dahsah, Chanyah; Bayer, Renee; Mun, Kongju

2014-03-01

The National Research Council's Framework for K- 12 Science Education and the Next Generation Science Standards (NGSS Lead States in Next Generation Science Standards: For states, by states. The National Academies Press, Washington, 2013) move teaching away from covering many isolated facts to a focus on a smaller number of disciplinary core ideas (DCIs) and crosscutting concepts that can be used to explain phenomena and solve problems by engaging in science and engineering practices. The NGSS present standards as knowledge-in-use by expressing them as performance expectations (PEs) that integrate all three dimensions from the Framework for K- 12 Science Education. This integration of core ideas, practices, and crosscutting concepts is referred to as three-dimensional learning (NRC in Division of Behavioral and Social Sciences and Education. The National Academies Press, Washington, 2014). PEs state what students can be assessed on at the end of grade level for K-5 and at the end of grade band for 6-8 and 9-12. PEs do not specify how instruction should be developed nor do they serve as objectives for individual lessons. To support students in developing proficiency in the PEs, the elements of the DCIs will need to be blended with various practices and crosscutting concepts. In this paper, we examine how to design instruction to support students in meeting a cluster or "bundle" of PEs and how to blend the three dimensions to develop lesson level PEs that can be used for guiding instruction. We provide a ten-step process and an example of that process that teachers and curriculum designers can use to design lessons that meet the intent of the Next Generation of Science Standards.

SpaceX's Dragon America's next generation spacecraft

CERN Document Server

Seedhouse, Erik

2016-01-01

This book describes Dragon V2, a futuristic vehicle that not only provides a means for NASA to transport its astronauts to the orbiting outpost but also advances SpaceX’s core objective of reusability. A direct descendant of Dragon, Dragon V2 can be retrieved, refurbished and re-launched. It is a spacecraft with the potential to completely revolutionize the economics of an industry where equipment costing hundreds of millions of dollars is routinely discarded after a single use. It was presented by SpaceX CEO Elon Musk in May 2014 as the spaceship that will carry NASA astronauts to the International Space Station as soon as 2016 SpaceX’s Dragon – America’s Next Generation Spacecraft describes the extraordinary feats of engineering and human achievement that have placed this revolutionary spacecraft at the forefront of the launch industry and positioned it as the precursor for ultimately transporting humans to Mars. It describes the design and development of Dragon, provides mission highlights of the f...

The opto-mechanical design for GMOX: a next-generation instrument concept for Gemini

Science.gov (United States)

Smee, Stephen A.; Barkhouser, Robert; Robberto, Massimo; Ninkov, Zoran; Gennaro, Mario; Heckman, Timothy M.

2016-08-01

We present the opto-mechanical design of GMOX, the Gemini Multi-Object eXtra-wide-band spectrograph, a potential next-generation (Gen-4 #3) facility-class instrument for Gemini. GMOX is a wide-band, multi-object, spectrograph with spectral coverage spanning 350 nm to 2.4 um with a nominal resolving power of R 5000. Through the use of Digital Micromirror Device (DMD) technology, GMOX will be able to acquire spectra from hundreds of sources simultaneously, offering unparalleled flexibility in target selection. Utilizing this technology, GMOX can rapidly adapt individual slits to either seeing-limited or diffraction-limited conditions. The optical design splits the bandpass into three arms, blue, red, and near infrared, with the near-infrared arm being split into three channels covering the Y+J band, H band, and K band. A slit viewing camera in each arm provides imaging capability for target acquisition and fast-feedback for adaptive optics control with either ALTAIR (Gemini North) or GeMS (Gemini South). Mounted at the Cassegrain focus, GMOX is a large (1.3 m x 2.8 m x 2.0 m) complex instrument, with six dichroics, three DMDs (one per arm), five science cameras, and three acquisition cameras. Roughly half of these optics, including one DMD, operate at cryogenic temperature. To maximize stiffness and simplify assembly and alignment, the opto-mechanics are divided into three main sub-assemblies, including a near-infrared cryostat, each having sub-benches to facilitate ease of alignment and testing of the optics. In this paper we present the conceptual opto-mechanical design of GMOX, with an emphasis on the mounting strategy for the optics and the thermal design details related to the near-infrared cryostat.

Nuclear Knowledge to the Next Generation

International Nuclear Information System (INIS)

Mazour, Thomas; Kossilov, Andrei

2004-01-01

The safe, reliable, and cost-effective operation of Nuclear Power Plants (NPPs) requires that personnel possess and maintain the requisite knowledge, skills, and attitudes to do their jobs properly. Such knowledge includes not only the technical competencies required by the nature of the technology and particular engineering designs, but also the softer competencies associated with effective management, communication and teamwork. Recent studies have shown that there has been a loss of corporate knowledge and memory. Both explicit knowledge and tacit knowledge must be passed on to the next generation of workers in the industry to ensure a quality workforce. New and different techniques may be required to ensure timely and effective knowledge retention and transfer. The IAEA prepared a report on this subject. The main conclusions from the report regarding strategies for managing the aging workforce are included. Also included are main conclusions from the report regarding the capture an d preservation of mission critical knowledge, and the effective transfer of this knowledge to the next generation of NPP personnel. The nuclear industry due to its need for well-documented procedures, specifications, design basis, safety analyses, etc., has a greater fraction of its mission critical knowledge as explicit knowledge than do many other industries. This facilitates the task of knowledge transfer. For older plants in particular, there may be a need for additional efforts to transfer tacit knowledge to explicit knowledge to support major strategic initiatives such as plant license extensions/renewals, periodic safety reviews, major plant upgrades, and plant specific control room simulator development. The challenge in disseminating explicit knowledge is to make employees aware that it is available and provide easy access in formats and forms that are usable. Tacit knowledge is more difficult to identify and disseminate. The challenge is to identify what can be converted to

Efficient Cryptography for the Next Generation Secure Cloud

Science.gov (United States)

Kupcu, Alptekin

2010-01-01

Peer-to-peer (P2P) systems, and client-server type storage and computation outsourcing constitute some of the major applications that the next generation cloud schemes will address. Since these applications are just emerging, it is the perfect time to design them with security and privacy in mind. Furthermore, considering the high-churn…

Dynalight Next Generation

DEFF Research Database (Denmark)

Jørgensen, Bo Nørregaard; Ottosen, Carl-Otto; Dam-Hansen, Carsten

2016-01-01

The project aims to develop the next generation of energy cost-efficient artificial lighting control that enables greenhouse growers to adapt their use of artificial lighting dynamically to fluctuations in the price of electricity. This is a necessity as fluctuations in the price of electricity c...

Feasibility of N-Gram Data-Structures for Next-Generation Pathogen Signature Design

Energy Technology Data Exchange (ETDEWEB)

Gardner, S N

2009-01-26

We determined the most appropriate data structure for handling n-gram (also known as k-mer) string comparisons and storage for genomic sequence data that will scale in terms of memory and speed. This is critical to maintain LLNL as the leader in pathogen detection, as it will guide the design of the 'Next Generation' system for computational signature prediction. There are two parts to k-mer analysis for signature prediction that we investigated. First is the enumeration and frequency counting of all observed k-mers in a sequence database (k-mer is a biological term equivalent to the CS term n-gram). Second is the down-selection and pairing of k-mers to generate a signature. We determined that for the first part, suffix arrays are the preferred method to enumerate k-mers, being memory efficient and relatively easy and fast to compute. For the second part, a subset of the k-mers can be stored and manipulated in a hash, that subset determination based on desired frequency characteristics such as most/least frequent from a set, shared among sequence sets, or discriminating across sequence sets.

Next-generation mammalian genetics toward organism-level systems biology.

Science.gov (United States)

Susaki, Etsuo A; Ukai, Hideki; Ueda, Hiroki R

2017-01-01

Organism-level systems biology in mammals aims to identify, analyze, control, and design molecular and cellular networks executing various biological functions in mammals. In particular, system-level identification and analysis of molecular and cellular networks can be accelerated by next-generation mammalian genetics. Mammalian genetics without crossing, where all production and phenotyping studies of genome-edited animals are completed within a single generation drastically reduce the time, space, and effort of conducting the systems research. Next-generation mammalian genetics is based on recent technological advancements in genome editing and developmental engineering. The process begins with introduction of double-strand breaks into genomic DNA by using site-specific endonucleases, which results in highly efficient genome editing in mammalian zygotes or embryonic stem cells. By using nuclease-mediated genome editing in zygotes, or ~100% embryonic stem cell-derived mouse technology, whole-body knock-out and knock-in mice can be produced within a single generation. These emerging technologies allow us to produce multiple knock-out or knock-in strains in high-throughput manner. In this review, we discuss the basic concepts and related technologies as well as current challenges and future opportunities for next-generation mammalian genetics in organism-level systems biology.

The Quest for Rare Variants: Pooled Multiplexed Next Generation Sequencing in Plants

OpenAIRE

Fabio eMarroni; Sara ePinosio; Sara ePinosio; Michele eMorgante

2012-01-01

Next generation sequencing (NGS) instruments produce an unprecedented amount of sequence data at contained costs. This gives researchers the possibility of designing studies with adequate power to identify rare variants at a fraction of the economic and labor resources required by individual Sanger sequencing. As of today, only three research groups working in plant sciences have exploited this potentiality. They showed that pooled NGS can provide results in excellent agreement with those obt...

The Quest for Rare Variants: Pooled Multiplexed Next Generation Sequencing in Plants

OpenAIRE

Marroni, Fabio; Pinosio, Sara; Morgante, Michele

2012-01-01

Next generation sequencing (NGS) instruments produce an unprecedented amount of sequence data at contained costs. This gives researchers the possibility of designing studies with adequate power to identify rare variants at a fraction of the economic and labor resources required by individual Sanger sequencing. As of today, few research groups working in plant sciences have exploited this potentiality, showing that pooled NGS provides results in excellent agreement with those obtained by indiv...

Generation 'Next' and nuclear power

International Nuclear Information System (INIS)

Sergeev, A.A.

2001-01-01

My generation was labeled by Russian mass media as generation 'Next.' My technical education is above average. My current position is as a mechanical engineer in the leading research and development institute for Russian nuclear engineering for peaceful applications. It is noteworthy to point out that many of our developments were really first-of-a-kind in the history of engineering. However, it is difficult to grasp the importance of these accomplishments, especially since the progress of nuclear technologies is at a standstill. Can generation 'Next' be independent in their attitude towards nuclear power or shall we rely on the opinions of elder colleagues in our industry? (authors)

Modelling of control system architecture for next-generation accelerators

International Nuclear Information System (INIS)

Liu, Shi-Yao; Kurokawa, Shin-ichi

1990-01-01

Functional, hardware and software system architectures define the fundamental structure of control systems. Modelling is a protocol of system architecture used in system design. This paper reviews various modellings adopted in past ten years and suggests a new modelling for next generation accelerators. (author)

What Is Web 2.0: Design Patterns and Business Models for the Next Generation of Software

OpenAIRE

O'Reilly, Tim

2007-01-01

This paper was the first initiative to try to define Web2.0 and understand its implications for the next generation of software, looking at both design patterns and business modes. Web 2.0 is the network as platform, spanning all connected devices; Web 2.0 applications are those that make the most of the intrinsic advantages of that platform: delivering software as a continually-updated service that gets better the more people use it, consuming and remixing data from multiple sources, includi...

Modeling the video distribution link in the Next Generation Optical Access Networks

DEFF Research Database (Denmark)

Amaya, F.; Cárdenas, A.; Tafur Monroy, Idelfonso

2011-01-01

In this work we present a model for the design and optimization of the video distribution link in the next generation optical access network. We analyze the video distribution performance in a SCM-WDM link, including the noise, the distortion and the fiber optic nonlinearities. Additionally, we...... consider in the model the effect of distributed Raman amplification, used to extent the capacity and the reach of the optical link. In the model, we use the nonlinear Schrödinger equation with the purpose to obtain capacity limitations and design constrains of the next generation optical access networks....

Next-Generation Sequencing of Tubal Intraepithelial Carcinomas.

Science.gov (United States)

McDaniel, Andrew S; Stall, Jennifer N; Hovelson, Daniel H; Cani, Andi K; Liu, Chia-Jen; Tomlins, Scott A; Cho, Kathleen R

2015-11-01

High-grade serous carcinoma (HGSC) is the most prevalent and lethal form of ovarian cancer. HGSCs frequently arise in the distal fallopian tubes rather than the ovary, developing from small precursor lesions called serous tubal intraepithelial carcinomas (TICs, or more specifically, STICs). While STICs have been reported to harbor TP53 mutations, detailed molecular characterizations of these lesions are lacking. We performed targeted next-generation sequencing (NGS) on formalin-fixed, paraffin-embedded tissue from 4 women, 2 with HGSC and 2 with uterine endometrioid carcinoma (UEC) who were diagnosed as having synchronous STICs. We detected concordant mutations in both HGSCs with synchronous STICs, including TP53 mutations as well as assumed germline BRCA1/2 alterations, confirming a clonal association between these lesions. Next-generation sequencing confirmed the presence of a STIC clonally unrelated to 1 case of UEC, and NGS of the other tubal lesion diagnosed as a STIC unexpectedly supported the lesion as a micrometastasis from the associated UEC. We demonstrate that targeted NGS can identify genetic alterations in minute lesions, such as TICs, and confirm TP53 mutations as early driving events for HGSC. Next-generation sequencing also demonstrated unexpected associations between presumed STICs and synchronous carcinomas, providing evidence that some TICs are actually metastases rather than HGSC precursors.

The Next Great Generation?

Science.gov (United States)

Brownstein, Andrew

2000-01-01

Discusses ideas from a new book, "Millennials Rising: The Next Great Generation," (by Neil Howe and William Strauss) suggesting that youth culture is on the cusp of a radical shift with the generation beginning with this year's college freshmen who are typically team oriented, optimistic, and poised for greatness on a global scale. Includes a…

Next generation surveillance system (NGSS)

International Nuclear Information System (INIS)

Aparo, Massimo

2006-01-01

Development of 'functional requirements' for transparency systems may offer a near-term mode of regional cooperation. New requirements under development at the IAEA may provide a foundation for this potential activity. The Next Generation Surveillance System (NGSS) will become the new IAEA remote monitoring system Under new requirements the NGSS would attempt to use more commercial components to reduce cost, increase radiation survivability and further increase reliability. The NGSS must be available in two years due to rapidly approaching obsolescence in the existing DCM family. (author)

Next Generation TRD for CREAM Using Gas Straw Tubes and Foam Radiators

Science.gov (United States)

Malinin, A.; Ahn, H.S.; Fedin, O.; Ganel, O.; Han, J.H.; Kim, C.H.; Kim, K.C.; Lee, M.H.; Lutz, L.; Seo, E.S.; Walpole, P.; Wu, J.; Yoo, J.H.; Yoon, Y.S.; Zinn, S.Y.

The Cosmic Ray Energetics And Mass (CREAM) experiment is designed to investigate the source, propagation and acceleration mechanism of high energy cosmic-ray nuclei, by directly measuring their energy and charge. Incorporating a transition radiation detector (TRD) provides an energy measurement complementary to the calorimeter, as well as additional track reconstruction capability. The next generation CREAM TRD is designed with 4 mm straw tubes to greatly improve tracking over the previous 20 mm tube design, thereby enhancing charge identification in the silicon charge detector (SCD). Plastic foam provides a weight-efficient radiator that doubles as a mechanical support for the straw layers. This design provides a compact, robust, reliable, low density detector to measure incident nucleus energy for 3 < Z < 30 nuclei in the Lorentz gamma factor range of 102-105. This paper discusses the new TRD design and the low power front end electronics used to achieve the large dynamic range required. Beam test results of a prototype TRD are also reported.

NEXT GENERATION TURBINE SYSTEM STUDY

Energy Technology Data Exchange (ETDEWEB)

Frank Macri

2002-02-28

Rolls-Royce has completed a preliminary design and marketing study under a Department of Energy (DOE) cost shared contract (DE-AC26-00NT40852) to analyze the feasibility of developing a clean, high efficiency, and flexible Next Generation Turbine (NGT) system to meet the power generation market needs of the year 2007 and beyond. Rolls-Royce evaluated the full range of its most advanced commercial aerospace and aeroderivative engines alongside the special technologies necessary to achieve the aggressive efficiency, performance, emissions, economic, and flexibility targets desired by the DOE. Heavy emphasis was placed on evaluating the technical risks and the economic viability of various concept and technology options available. This was necessary to ensure the resulting advanced NGT system would provide extensive public benefits and significant customer benefits without introducing unacceptable levels of technical and operational risk that would impair the market acceptance of the resulting product. Two advanced cycle configurations were identified as offering significant advantages over current combined cycle products available in the market. In addition, balance of plant (BOP) technologies, as well as capabilities to improve the reliability, availability, and maintainability (RAM) of industrial gas turbine engines, have been identified. A customer focused survey and economic analysis of a proposed Rolls-Royce NGT product configuration was also accomplished as a part of this research study. The proposed Rolls-Royce NGT solution could offer customers clean, flexible power generation systems with very high efficiencies, similar to combined cycle plants, but at a much lower specific cost, similar to those of simple cycle plants.

Next generation reactor development activity at Hitachi, Ltd

International Nuclear Information System (INIS)

Yamashita, Junichi

2005-01-01

Developments of innovative nuclear systems in Japan have been highly requested to cope with uncertain future nuclear power generation and fuel cycle situation. Next generation reactor system shall be surely deployed earlier to be capable to provide with several options such as plutonium multi-recycle, intermediate storage of spent fuels, simplified reprocessing of spent fuels and separated storage of 'Pu+FP' and 'U', spent fuels storage after Pu LWR recycle and their combinations, while future reactor system will be targeted at ideal fuel recycle system of higher breeding gain and transmutation of radioactive wastes. Modified designs of the ABWR at large size and medium and small size have been investigated as well as a BWR based RMWR and a supercritical-pressure LWR to ensure safety and improve economics. Advanced fuel cycle technologies of a combination of fluoride volatility process and PUREX process with high decontamination (FLUOREX process) and a modified fluoride volatility process with low decontamination have been developed. (T. Tanaka)

DIII-D Integrated plasma control solutions for ITER and next-generation tokamaks

International Nuclear Information System (INIS)

Humphreys, D.A.; Ferron, J.R.; Hyatt, A.W.; La Haye, R.J.; Leuer, J.A.; Penaflor, B.G.; Walker, M.L.; Welander, A.S.; In, Y.

2008-01-01

Plasma control design approaches and solutions developed at DIII-D to address its control-intensive advanced tokamak (AT) mission are applicable to many problems facing ITER and other next-generation devices. A systematic approach to algorithm design, termed 'integrated plasma control,' enables new tokamak controllers to be applied operationally with minimal machine time required for tuning. Such high confidence plasma control algorithms are designed using relatively simple ('control-level') models validated against experimental response data and are verified in simulation prior to operational use. A key element of DIII-D integrated plasma control, also required in the ITER baseline control approach, is the ability to verify both controller performance and implementation by running simulations that connect directly to the actual plasma control system (PCS) that is used to operate the tokamak itself. The DIII-D PCS comprises a powerful and flexible C-based realtime code and programming infrastructure, as well as an arbitrarily scalable hardware and realtime network architecture. This software infrastructure provides a general platform for implementation and verification of realtime algorithms with arbitrary complexity, limited only by speed of execution requirements. We present a complete suite of tools (known collectively as TokSys) supporting the integrated plasma control design process, along with recent examples of control algorithms designed for the DIII-D PCS. The use of validated physics-based models and a systematic model-based design and verification process enables these control solutions to be directly applied to ITER and other next-generation tokamaks

Next-generation storm tracking for minimizing service interruption

Energy Technology Data Exchange (ETDEWEB)

Sznaider, R. [Meteorlogix, Minneapolis, MN (United States)

2002-08-01

Several technological changes have taken place in the field of weather radar since its discovery during World War II. A wide variety of industries have benefited over the years from conventional weather radar displays, providing assistance in forecasting and estimating the potential severity of storms. The characteristics of individual storm cells can now be derived from the next-generation of weather radar systems (NEXRAD). The determination of which storm cells possess distinct features such as large hail or developing tornadoes was made possible through the fusing of various pieces of information with radar pictures. To exactly determine when and where a storm will hit, this data can be combined and overlaid into a display that includes the geographical physical landmarks of a specific region. Combining Geographic Information Systems (GIS) and storm tracking provides a more complete, timely and accurate forecast, which clearly benefits the electric utilities industries. The generation and production of energy are dependent on how hot or cold it will be today and tomorrow. The author described each major feature of this next-generation weather radar system. 9 figs.

HLA typing: Conventional techniques v.next-generation sequencing

African Journals Online (AJOL)

The existing techniques have contributed significantly to our current knowledge of allelic diversity. At present, sequence-based typing (SBT) methods, in particular next-generation sequencing. (NGS), provide the highest possible resolution. NGS platforms were initially only used for genomic sequencing, but also showed.

Next Generation CANDU: Conceptual Design for a Short Construction Schedule

International Nuclear Information System (INIS)

Hopwood, Jerry M.; Love, Ian J.W.; Elgohary, Medhat; Fairclough, Neville

2002-01-01

Atomic Energy of Canada Ltd. (AECL) has very successful experience in implementing new construction methods at the Qinshan (Phase III) twin unit CANDU 6 plant in China. This paper examines the construction method that must be implemented during the conceptual design phase of a project if short construction schedules are to be met. A project schedule of 48 months has been developed for the nth unit of NG (Next Generation) CANDU with a 42 month construction period from 1. Concrete to In-Service. An overall construction strategy has been developed involving paralleling project activities that are normally conducted in series. Many parts of the plant will be fabricated as modules and be installed using heavy lift cranes. The Reactor Building (RB), being on the critical path, has been the focus of considerable assessment, looking at alternative ways of applying the construction strategy to this building. A construction method has been chosen which will result in excess of 80% of internal work being completed as modules or as very streamlined traditional construction. This method is being further evaluated as the detailed layout proceeds. Other areas of the plant have been integrated into the schedule and new construction methods are being applied to these so that further modularization and even greater paralleling of activities will be achieved. It is concluded that the optimized construction method is a requirement, which must be implemented through all phases of design to make a 42 month construction schedule a reality. If the construction methods are appropriately chosen, the schedule reductions achieved will make nuclear more competitive. (authors)

Design and implementation of the next generation Landsat satellite communications system

Science.gov (United States)

Mah, Grant R.; O'Brien, Michael; Garon, Howard; Mott, Claire; Ames, Alan; Dearth, Ken

2012-01-01

The next generation Landsat satellite, Landsat 8 (L8), also known as the Landsat Data Continuity Mission (LDCM), uses a highly spectrally efficient modulation and data formatting approach to provide large amounts of downlink (D/L) bandwidth in a limited X-Band spectrum allocation. In addition to purely data throughput and bandwidth considerations, there were a number of additional constraints based on operational considerations for prevention of interference with the NASA Deep-Space Network (DSN) band just above the L8 D/L band, minimization of jitter contributions to prevent impacts to instrument performance, and the need to provide an interface to the Landsat International Cooperator (IC) community. A series of trade studies were conducted to consider either X- or Ka-Band, modulation type, and antenna coverage type, prior to the release of the request for proposal (RFP) for the spacecraft. Through use of the spectrally efficient rate-7/8 Low-Density Parity-Check error-correction coding and novel filtering, an XBand frequency plan was developed that balances all the constraints and considerations, while providing world-class link performance, fitting 384 Mbits/sec of data into the 375 MHz X-Band allocation with bit-error rates better than 10-12 using an earth-coverage antenna.

Next generation breeding.

Science.gov (United States)

Barabaschi, Delfina; Tondelli, Alessandro; Desiderio, Francesca; Volante, Andrea; Vaccino, Patrizia; Valè, Giampiero; Cattivelli, Luigi

2016-01-01

The genomic revolution of the past decade has greatly improved our understanding of the genetic make-up of living organisms. The sequencing of crop genomes has completely changed our vision and interpretation of genome organization and evolution. Re-sequencing allows the identification of an unlimited number of markers as well as the analysis of germplasm allelic diversity based on allele mining approaches. High throughput marker technologies coupled with advanced phenotyping platforms provide new opportunities for discovering marker-trait associations which can sustain genomic-assisted breeding. The availability of genome sequencing information is enabling genome editing (site-specific mutagenesis), to obtain gene sequences desired by breeders. This review illustrates how next generation sequencing-derived information can be used to tailor genomic tools for different breeders' needs to revolutionize crop improvement. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Next generation solar energy. From fundamentals to applications

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

Within the International Conference between 12th and 14th December, 2011 in Erlangen (Federal Republic of Germany) the following lectures were presented: (1) The opto-electronic physics required to approach the Shockley-Queisser efficiency limit (E. Yablonovitch); (2) The Shockley-Queisser-limit and beyond (G.H. Bauer); (3) Designing composite nanomaterials for photovoltaic devices (B. Rech); (4) Light-Material interactions in energy conversion (H. Atwater); (5) Functional imaging of hybrid nanostructures - Visualizing mechanisms of solar energy utilization (L. Lauhon); (6) Are photosynthetic proteins suitable for PV applications (Y. Rosenwaks); (7) Detailed balance limit in photovoltaic systems (U. Rau); (8) Plasmonics and nanophotonics for next generation photovoltaics (E. Garnett); (9) Dispersion, wave propagation and efficiency analysis of nanowire solar cells (B. Witzigmann); (10) Application of nanostructures to next generation photovoltaics - Opportunities and challenges from an industrial research perspective (L. Tsakalakos); (11) Triplet states in organic and organometallic photovoltaic cells (K.S. Schanze); (12) New photoelectrode architectures (J.T. Hupp); (13) Dendrimers for optoelectronic and photovoltaic applications (P. Ceroni); (14) Photon management with luminescent materials (J. Goldschmidt); (15) Economical aspects of next generation solar cell technologies (W. Hoffmann); (16) Scalability in solar energy conversion - First-row transition metal-based chromophores for dye-sensitized solar cells (J. McCusker); (17) Designing organic materials for photovoltaic devices (A. Harriman); (18) Molecular photovoltaics - What can we learn from model studies (B. Albinsson); (19) Porphyrin-sensitised titanium dioxide solar cells (D. Officer); (20) Light-harvesting: Charge separation, and charge-transportation properties of novel materials for organic photovoltaics (H. Imahori); (21) Phthalocyanines for molecular photovoltaics (T. Torres); (22) Photophysics of

Dependable Hydrogen and Industrial Heat Generation from the Next Generation Nuclear Plant

Energy Technology Data Exchange (ETDEWEB)

Charles V. Park; Michael W. Patterson; Vincent C. Maio; Piyush Sabharwall

2009-03-01

The Department of Energy is working with industry to develop a next generation, high-temperature gas-cooled nuclear reactor (HTGR) as a part of the effort to supply the US with abundant, clean and secure energy. The Next Generation Nuclear Plant (NGNP) project, led by the Idaho National Laboratory, will demonstrate the ability of the HTGR to generate hydrogen, electricity, and high-quality process heat for a wide range of industrial applications. Substituting HTGR power for traditional fossil fuel resources reduces the cost and supply vulnerability of natural gas and oil, and reduces or eliminates greenhouse gas emissions. As authorized by the Energy Policy Act of 2005, industry leaders are developing designs for the construction of a commercial prototype producing up to 600 MWt of power by 2021. This paper describes a variety of critical applications that are appropriate for the HTGR with an emphasis placed on applications requiring a clean and reliable source of hydrogen. An overview of the NGNP project status and its significant technology development efforts are also presented.

Issues for Conceptual Design of AFCF and CFTC LWR Spent Fuel Separations Influencing Next-Generation Aqueous Fuel Reprocessing

International Nuclear Information System (INIS)

D. Hebditch; R. Henry; M. Goff; K. Pasamehmetoglu; D. Ostby

2007-01-01

In 2007, the U.S. Department of Energy (DOE) published the Global Nuclear Energy Partnership (GNEP) strategic plan, which aims to meet US and international energy, safeguards, fuel supply and environmental needs by harnessing national laboratory R and D, deployment by industry and use of international partnerships. Initially, two industry-led commercial scale facilities, an advanced burner reactor (ABR) and a consolidated fuel treatment center (CFTC), and one developmental facility, an advanced fuel cycle facility (AFCF) are proposed. The national laboratories will lead the AFCF to provide an internationally recognized R and D center of excellence for developing transmutation fuels and targets and advancing fuel cycle reprocessing technology using aqueous and pyrochemical methods. The design drivers for AFCF and the CFTC LWR spent fuel separations are expected to impact on and partly reflect those for industry, which is engaging with DOE in studies for CFTC and ABR through the recent GNEP funding opportunity announcement (FOA). The paper summarizes the state-of-the-art of aqueous reprocessing, gives an assessment of engineering drivers for U.S. aqueous processing facilities, examines historic plant capital costs and provides conclusions with a view to influencing design of next-generation fuel reprocessing plants

NIRS report of investigations for the development of the next generation PET apparatus. FY 2000

International Nuclear Information System (INIS)

2001-03-01

This is a summary of study reports from representative technology fields for the development of the next generation PET apparatus directing to 3-D images, and is hoped to be useful for future smooth cooperation between the fields. The investigation started from April 2000 in National Institute of Radiological Sciences (NIRS) with cooperation of other facilities, universities and companies. The report involves chapters of: Detector volume and geometrical efficiency- Design criterion for the next generation PET; Scintillator for PET; An investigation of detector and front-end electronics for the next generation PET; A measurement system of depth of interaction; Detector simulator; Development of an evaluation system for PET detector; On the signal processing system for the next generation PET; List-mode data acquisition method for the next generation PET; List-mode data acquisition simulator; Image reconstruction; A Monte Carlo simulator for the next generation PET scanners; Out-of-field of view (FOV) radioactivity; and Published papers and presentations. (N.I.)

Epidemiological Studies to Support the Development of Next Generation Influenza Vaccines.

Science.gov (United States)

Petrie, Joshua G; Gordon, Aubree

2018-03-26

The National Institute of Allergy and Infectious Diseases recently published a strategic plan for the development of a universal influenza vaccine. This plan focuses on improving understanding of influenza infection, the development of influenza immunity, and rational design of new vaccines. Epidemiological studies such as prospective, longitudinal cohort studies are essential to the completion of these objectives. In this review, we discuss the contributions of epidemiological studies to our current knowledge of vaccines and correlates of immunity, and how they can contribute to the development and evaluation of the next generation of influenza vaccines. These studies have been critical in monitoring the effectiveness of current influenza vaccines, identifying issues such as low vaccine effectiveness, reduced effectiveness among those who receive repeated vaccination, and issues related to egg adaptation during the manufacturing process. Epidemiological studies have also identified population-level correlates of protection that can inform the design and development of next generation influenza vaccines. Going forward, there is an enduring need for epidemiological studies to continue advancing knowledge of correlates of protection and the development of immunity, to evaluate and monitor the effectiveness of next generation influenza vaccines, and to inform recommendations for their use.

Development of a framework for the neutorinics analysis system for next generation (2) (Contract research)

International Nuclear Information System (INIS)

Hirai, Yasushi; Hyoudou, Hideaki; Tatsumi, Masahiro; Jin, Tomoyuki; Yokoyama, Kenji

2008-10-01

Japan Atomic Energy Agency promotes development of innovative analysis methods and models in fundamental studies for next-generation nuclear reactor systems. In order to efficiently and effectively reflect the latest analysis methods and models to primary design of prototype reactor and/or in-core fuel management for power reactors, a next-generation analysis system MARBLE has been developed. The next-generation system provides solutions to the following requirements: (1) Flexibility, extensibility and user-friendliness that can apply new methods and models rapidly and effectively for fundamental studies, (2) quantitative assurance of solution accuracy and adaptive scoping range for design studies, (3) coupling analysis among different study domains for the purpose of rationalization of plant systems and improvement of reliability, (4) maintainability and reusability for system extensions for the purpose of total quality assurance and development efficiency. There has been a problem of extreme inefficiency due to lack of functionality in the conventional analysis system when changing analysis targets and/or modeling levels. In order to solve this problem, a policy of the hybrid system is adopted for the next-generation system, in which a controlling part is implemented in the scripting language with rich flexibility and maintainability and solution kernels that requires execution speed in the system language. In this study, detailed design of a framework, its implementation and tests are conducted so that a Python system layer can drive calculation codes written in C++ and/or Fortran. It is confirmed that various type of calculation codes such as diffusion, transport and burnup codes can be treated in the same manner on the platform for unified management system for calculation codes with a data exchange mechanism for abstracted data model between the Python and the calculation code layers. (author)

Designing Next Generation Rechargeable Battery Materials from First-Principles

Science.gov (United States)

Kim, Soo

interacting with Mn3+ at the (001) LMO surface, promoting an oxidation state change to Mn4+. In addition, we find that graphene defects also react with H2O and generated HF, protecting the active cathode materials from the attack of HF generated in the electrolyte during cycling. The carbonyl and epoxy functional groups in graphene oxide (GO) serve as a physical barrier to mitigate Mn ion dissolution into the liquid electrolyte, stabilizing the overall cell cycling performance. Next, we examine the occurrence of low- and high-temperature LiCoO2 structures and their observed voltage profiles in order to understand the complex structural and electrochemical behaviors. Moreover, a structural search is conducted to identify a new over-lithiated spinel oxide composition, i.e., Fd3¯m LiNi0.8125Co0.1875O2, which may have potential for exploitation in structurally-integrated, 'layered-spinel' cathode system. We have further investigated the structural and electrochemical properties of 'layered-layered-spinel' xLi 2MnO3˙yLiNi0.5Co0.2 Mn0.3O2˙zLiNi0.5Mn 1.5O4 cathode materials using both experiment and theory. Lastly, the idea of a multi-faceted high-throughput (HT) screening approach has been performed within the Open Quantum Materials Database (OQMD) framework to discover possible Li-rich Li2MIO3-Li 2MIIO3 pair combinations (MI,II = elements from the periodic table) that can offer better structural stability, favorable metal-mixing behavior, coherent interfaces, and high energy. Our approach involving computational design of novel materials and systems will accelerate the development of new sustainable energy solutions for meeting global demands.

Design of flexible polyphenylene proton-conducting membrane for next-generation fuel cells.

Science.gov (United States)

Miyake, Junpei; Taki, Ryunosuke; Mochizuki, Takashi; Shimizu, Ryo; Akiyama, Ryo; Uchida, Makoto; Miyatake, Kenji

2017-10-01

Proton exchange membrane fuel cells (PEMFCs) are promising devices for clean power generation in automotive, stationary, and portable applications. Perfluorosulfonic acid (PFSA) ionomers (for example, Nafion) have been the benchmark PEMs; however, several problems, including high gas permeability, low thermal stability, high production cost, and environmental incompatibility, limit the widespread dissemination of PEMFCs. It is believed that fluorine-free PEMs can potentially address all of these issues; however, none of these membranes have simultaneously met the criteria for both high performance (for example, proton conductivity) and durability (for example, mechanical and chemical stability). We present a polyphenylene-based PEM (SPP-QP) that fulfills the required properties for fuel cell applications. The newly designed PEM exhibits very high proton conductivity, excellent membrane flexibility, low gas permeability, and extremely high stability, with negligible degradation even under accelerated degradation conditions, which has never been achieved with existing fluorine-free PEMs. The polyphenylene PEM also exhibits reasonably high fuel cell performance, with excellent durability under practical conditions. This new PEM extends the limits of existing fluorine-free proton-conductive materials and will help to realize the next generation of PEMFCs via cost reduction as well as the performance improvement compared to the present PFSA-based PEMFC systems.

Next Generation Inverter

Energy Technology Data Exchange (ETDEWEB)

Zhao, Zilai [General Motors LLC, Detroit, MI (United States); Gough, Charles [General Motors LLC, Detroit, MI (United States)

2016-04-22

The goal of this Cooperative Agreement was the development of a Next Generation Inverter for General Motors’ electrified vehicles, including battery electric vehicles, range extended electric vehicles, plug-in hybrid electric vehicles and hybrid electric vehicles. The inverter is a critical electronics component that converts battery power (DC) to and from the electric power for the motor (AC).

Synchronization System for Next Generation Light Sources

Energy Technology Data Exchange (ETDEWEB)

Zavriyev, Anton [MagiQ Technologies, Inc., Somerville, MA (United States)

2014-03-27

An alternative synchronization technique – one that would allow explicit control of the pulse train including its repetition rate and delay is clearly desired. We propose such a scheme. Our method is based on optical interferometry and permits synchronization of the pulse trains generated by two independent mode-locked lasers. As the next generation x-ray sources will be driven by a clock signal derived from a mode-locked optical source, our technique will provide a way to synchronize x-ray probe with the optical pump pulses.

Converged Wireless Networking and Optimization for Next Generation Services

Directory of Open Access Journals (Sweden)

J. Rodriguez

2010-01-01

Full Text Available The Next Generation Network (NGN vision is tending towards the convergence of internet and mobile services providing the impetus for new market opportunities in combining the appealing services of internet with the roaming capability of mobile networks. However, this convergence does not go far enough, and with the emergence of new coexistence scenarios, there is a clear need to evolve the current architecture to provide cost-effective end-to-end communication. The LOOP project, a EUREKA-CELTIC driven initiative, is one piece in the jigsaw by helping European industry to sustain a leading role in telecommunications and manufacturing of high-value products and machinery by delivering pioneering converged wireless networking solutions that can be successfully demonstrated. This paper provides an overview of the LOOP project and the key achievements that have been tunneled into first prototypes for showcasing next generation services for operators and process manufacturers.

Next Generation Nuclear Plant System Requirements Manual

International Nuclear Information System (INIS)

Not Listed

2008-01-01

System Requirements Manual for the NGNP Project. The Energy Policy Act of 2005 (H.R. 6; EPAct), which was signed into law by President George W. Bush in August 2005, required the Secretary of the U.S. Department of Energy (DOE) to establish a project to be known as the Next Generation Nuclear Plant (NGNP) Project. According to the EPAct, the NGNP Project shall consist of the research, development, design, construction, and operation of a prototype plant (to be referred to herein as the NGNP) that (1) includes a nuclear reactor based on the research and development (R and D) activities supported by the Generation IV Nuclear Energy Systems initiative, and (2) shall be used to generate electricity, to produce hydrogen, or to both generate electricity and produce hydrogen. The NGNP Project supports both the national need to develop safe, clean, economical nuclear energy and the Nuclear Hydrogen Initiative (NHI), which has the goal of establishing greenhouse-gas-free technologies for the production of hydrogen. The DOE has selected the helium-cooled High Temperature Gas-Cooled Reactor (HTGR) as the reactor concept to be used for the NGNP because it is the only near-term Generation IV concept that has the capability to provide process heat at high-enough temperatures for highly efficient production of hydrogen. The EPAct also names the Idaho National Laboratory (INL), the DOE's lead national laboratory for nuclear energy research, as the site for the prototype NGNP

An evaluation of prefilled insulin pens: a focus on the Next Generation FlexPen®

Directory of Open Access Journals (Sweden)

Estella M Davis

2010-08-01

Full Text Available Estella M Davis, Emily L Sexson, Mikayla L Spangler, Pamela A ForalDepartment of Pharmacy Practice, Creighton University School of Pharmacy and Health Professions, Omaha, Nebraska, USAAbstract: Insulin pen delivery systems are preferred by patients over the traditional vial and syringe method for insulin delivery because they are simple and easy to use, improve confidence in dosing insulin, and have less interference with activities and improved discretion with use. Insulin manufacturers have made numerous improvements to their first marketed pen devices and are now introducing their next generation of devices. Design modifications to the newest generation of prefilled insulin pen devices are intended to improve the ease of use and safety and continue to positively impact adherence to insulin. This review focuses on the Next Generation FlexPen® with regard to design considerations to reduce injection force, improve accuracy and ease of use, and evaluate the preference of patient and health-care provider compared with other disposable, prefilled insulin pen devices.Keywords: diabetes, dose accuracy, injection force, patient preference, insulin pen device

Persona: Network Layer Anonymity and Accountability for Next Generation Internet

Science.gov (United States)

Mallios, Yannis; Modi, Sudeep; Agarwala, Aditya; Johns, Christina

Individual privacy has become a major concern, due to the intrusive nature of the services and websites that collect increasing amounts of private information. One of the notions that can lead towards privacy protection is that of anonymity. Unfortunately, anonymity can also be maliciously exploited by attackers to hide their actions and identity. Thus some sort of accountability is also required. The current Internet has failed to provide both properties, as anonymity techniques are difficult to fully deploy and thus are easily attacked, while the Internet provides limited level of accountability. The Next Generation Internet (NGI) provides us with the opportunity to examine how these conflicting properties could be efficiently applied and thus protect users’ privacy while holding malicious users accountable. In this paper we present the design of a scheme, called Persona that can provide anonymity and accountability in the network layer of NGI. More specifically, our design requirements are to combine these two conflicting desires in a stateless manner within routers. Persona allows users to choose different levels of anonymity, while it allows the discovery of malicious nodes.

Middleware for the next generation Grid infrastructure

CERN Document Server

Laure, E; Prelz, F; Beco, S; Fisher, S; Livny, M; Guy, L; Barroso, M; Buncic, P; Kunszt, Peter Z; Di Meglio, A; Aimar, A; Edlund, A; Groep, D; Pacini, F; Sgaravatto, M; Mulmo, O

2005-01-01

The aim of the EGEE (Enabling Grids for E-Science in Europe) project is to create a reliable and dependable European Grid infrastructure for e-Science. The objective of the EGEE Middleware Re-engineering and Integration Research Activity is to provide robust middleware components, deployable on several platforms and operating systems, corresponding to the core Grid services for resource access, data management, information collection, authentication & authorization, resource matchmaking and brokering, and monitoring and accounting. For achieving this objective, we developed an architecture and design of the next generation Grid middleware leveraging experiences and existing components essentially from AliEn, EDG, and VDT. The architecture follows the service breakdown developed by the LCG ARDA group. Our strategy is to do as little original development as possible but rather re-engineer and harden existing Grid services. The evolution of these middleware components towards a Service Oriented Architecture ...

A Next Generation BioPhotonics Workstation

DEFF Research Database (Denmark)

Glückstad, Jesper; Palima, Darwin; Tauro, Sandeep

2011-01-01

We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials.......We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials....

Next Generation Microchannel Heat Exchangers

CERN Document Server

Ohadi, Michael; Dessiatoun, Serguei; Cetegen, Edvin

2013-01-01

In Next Generation Microchannel Heat Exchangers, the authors’ focus on the new generation highly efficient heat exchangers and presentation of novel data and technical expertise not available in the open literature.  Next generation micro channels offer record high heat transfer coefficients with pressure drops much less than conventional micro channel heat exchangers. These inherent features promise fast penetration into many mew markets, including high heat flux cooling of electronics, waste heat recovery and energy efficiency enhancement applications, alternative energy systems, as well as applications in mass exchangers and chemical reactor systems. The combination of up to the minute research findings and technical know-how make this book very timely as the search for high performance heat and mass exchangers that can cut costs in materials consumption intensifies.

A Window Into Clinical Next-Generation Sequencing-Based Oncology Testing Practices.

Science.gov (United States)

Nagarajan, Rakesh; Bartley, Angela N; Bridge, Julia A; Jennings, Lawrence J; Kamel-Reid, Suzanne; Kim, Annette; Lazar, Alexander J; Lindeman, Neal I; Moncur, Joel; Rai, Alex J; Routbort, Mark J; Vasalos, Patricia; Merker, Jason D

2017-12-01

- Detection of acquired variants in cancer is a paradigm of precision medicine, yet little has been reported about clinical laboratory practices across a broad range of laboratories. - To use College of American Pathologists proficiency testing survey results to report on the results from surveys on next-generation sequencing-based oncology testing practices. - College of American Pathologists proficiency testing survey results from more than 250 laboratories currently performing molecular oncology testing were used to determine laboratory trends in next-generation sequencing-based oncology testing. - These presented data provide key information about the number of laboratories that currently offer or are planning to offer next-generation sequencing-based oncology testing. Furthermore, we present data from 60 laboratories performing next-generation sequencing-based oncology testing regarding specimen requirements and assay characteristics. The findings indicate that most laboratories are performing tumor-only targeted sequencing to detect single-nucleotide variants and small insertions and deletions, using desktop sequencers and predesigned commercial kits. Despite these trends, a diversity of approaches to testing exists. - This information should be useful to further inform a variety of topics, including national discussions involving clinical laboratory quality systems, regulation and oversight of next-generation sequencing-based oncology testing, and precision oncology efforts in a data-driven manner.

Engineering mechanical gradients in next generation biomaterials - Lessons learned from medical textile design.

Science.gov (United States)

Ng, Joanna L; Collins, Ciara E; Knothe Tate, Melissa L

2017-07-01

Nonwoven and textile membranes have been applied both externally and internally to prescribe boundary conditions for medical conditions as diverse as oedema and tissue defects. Incorporation of mechanical gradients in next generation medical membrane design offers great potential to enhance function in a dynamic, physiological context. Yet the gradient properties and resulting mechanical performance of current membranes are not well described. To bridge this knowledge gap, we tested and compared the mechanical properties of bounding membranes used in both external (compression sleeves for oedema, exercise bands) and internal (surgical membranes) physiological contexts. We showed that anisotropic compression garment textiles, isotropic exercise bands and surgical membranes exhibit similar ranges of resistance to tension under physiologic strains. However, their mechanical gradients and resulting stress-strain relationships show differences in work capacity and energy expenditure. Exercise bands' moduli of elasticity and respective thicknesses allow for controlled, incremental increases in loading to facilitate healing as injured tissues return to normal structure and function. In contrast, the gradients intrinsic to compression sleeve design exhibit gaps in the middle range (1-5N) of physiological strains and also inconsistencies along the length of the sleeve, resulting in less than optimal performance of these devices. These current shortcomings in compression textile and garment design may be addressed in the future through implementation of novel approaches. For example, patterns, fibre compositions, and fibre anisotropy can be incorporated into biomaterial design to achieve seamless mechanical gradients in structure and resulting dynamic function, which would be particularly useful in physiological contexts. These concepts can be applied further to biomaterial design to deliver pressure gradients during movement of oedematous limbs (compression garments) and

Engineered CRISPR Systems for Next Generation Gene Therapies.

Science.gov (United States)

Pineda, Michael; Moghadam, Farzaneh; Ebrahimkhani, Mo R; Kiani, Samira

2017-09-15

An ideal in vivo gene therapy platform provides safe, reprogrammable, and precise strategies which modulate cell and tissue gene regulatory networks with a high temporal and spatial resolution. Clustered regularly interspaced short palindromic repeats (CRISPR), a bacterial adoptive immune system, and its CRISPR-associated protein 9 (Cas9), have gained attention for the ability to target and modify DNA sequences on demand with unprecedented flexibility and precision. The precision and programmability of Cas9 is derived from its complexation with a guide-RNA (gRNA) that is complementary to a desired genomic sequence. CRISPR systems open-up widespread applications including genetic disease modeling, functional screens, and synthetic gene regulation. The plausibility of in vivo genetic engineering using CRISPR has garnered significant traction as a next generation in vivo therapeutic. However, there are hurdles that need to be addressed before CRISPR-based strategies are fully implemented. Some key issues center on the controllability of the CRISPR platform, including minimizing genomic-off target effects and maximizing in vivo gene editing efficiency, in vivo cellular delivery, and spatial-temporal regulation. The modifiable components of CRISPR systems: Cas9 protein, gRNA, delivery platform, and the form of CRISPR system delivered (DNA, RNA, or ribonucleoprotein) have recently been engineered independently to design a better genome engineering toolbox. This review focuses on evaluating CRISPR potential as a next generation in vivo gene therapy platform and discusses bioengineering advancements that can address challenges associated with clinical translation of this emerging technology.

Next generation framework for aquatic modeling of the Earth System

Science.gov (United States)

Fekete, B. M.; Wollheim, W. M.; Wisser, D.; Vörösmarty, C. J.

2009-03-01

Earth System model development is becoming an increasingly complex task. As scientists attempt to represent the physical and bio-geochemical processes and various feedback mechanisms in unprecedented detail, the models themselves are becoming increasingly complex. At the same time, the complexity of the surrounding IT infrastructure is growing as well. Earth System models must manage a vast amount of data in heterogeneous computing environments. Numerous development efforts are on the way to ease that burden and offer model development platforms that reduce IT challenges and allow scientists to focus on their science. While these new modeling frameworks (e.g. FMS, ESMF, CCA, OpenMI) do provide solutions to many IT challenges (performing input/output, managing space and time, establishing model coupling, etc.), they are still considerably complex and often have steep learning curves. The Next generation Framework for Aquatic Modeling of the Earth System (NextFrAMES, a revised version of FrAMES) have numerous similarities to those developed by other teams, but represents a novel model development paradigm. NextFrAMES is built around a modeling XML that lets modelers to express the overall model structure and provides an API for dynamically linked plugins to represent the processes. The model XML is executed by the NextFrAMES run-time engine that parses the model definition, loads the module plugins, performs the model I/O and executes the model calculations. NextFrAMES has a minimalistic view representing spatial domains and treats every domain (regardless of its layout such as grid, network tree, individual points, polygons, etc.) as vector of objects. NextFrAMES performs computations on multiple domains and interactions between different spatial domains are carried out through couplers. NextFrAMES allows processes to operate at different frequencies by providing rudimentary aggregation and disaggregation facilities. NextFrAMES was designed primarily for

Laser peening applications for next generation of nuclear power facilities

International Nuclear Information System (INIS)

Rankin, J.; Truong, C.; Walter, M.; Chen, H.-L.; Hackel, L.

2008-01-01

Generation of electricity by nuclear power can assist in achieving goals of reduced greenhouse gas emissions. Increased safety and reliability are necessary attributes of any new nuclear power plants. High pressure, hot water and radiation contribute to operating environments where Stress Corrosion Cracking (SCC) and hydrogen embrittlement can lead to potential component failures. Desire for improved steam conversion efficiency pushes the fatigue stress limits of turbine blades and other rotating equipment. For nuclear reactor facilities now being designed and built and for the next generations of designs, laser peening could be incorporated to provide significant performance life to critical subsystems and components making them less susceptible to fatigue, SCC and radiation induced embrittlement. These types of components include steam turbine blades, hubs and bearings as well as reactor components including cladding material, housings, welded assemblies, fittings, pipes, flanges, vessel penetrations, nuclear waste storage canisters. Laser peening has proven to be a commercial success in aerospace applications and has recently been put into use for gas and steam turbine generators and light water reactors. An expanded role for this technology for the broader nuclear power industry would be a beneficial extension. (author)

Progress on next generation linear colliders

International Nuclear Information System (INIS)

Ruth, R.D.

1989-01-01

In this paper, I focus on reviewing the issues and progress on a next generation linear collider with the general parameters of energy, luminosity, length, power, technology. The energy range is dictated by physics with a mass reach well beyond LEP, although somewhat short of SSC. The luminosity is that required to obtain 10 3 /minus/ 10 4 units of R 0 per year. The length is consistent with a site on Stanford land with collisions occurring on the SLAC site. The power was determined by economic considerations. Finally, the technology was limited by the desire to have a next generation linear collider before the next century. 25 refs., 3 figs., 6 tabs

Residual stress control and design of next-generation ultra-hard gear steels

Science.gov (United States)

Qian, Yana

In high power density transmission systems, Ni-Co secondary hardening steels have shown great potential for next-generation gear applications due to their excellent strength, toughness and superior fatigue performance. Study of residual stress generation and evolution in Ferrium C61 and C67 gear steels revealed that shot peening and laser peening processes effectively produce desired beneficial residual stress in the steels for enhanced fatigue performance. Surface residual stress levels of -1.4GPa and -1.5GPa were achieved in shot peened C61 and laser peened C67, respectively, without introducing large surface roughness or defects. Higher compressive residual stress is expected in C67 according to a demonstrated correlation between attainable residual stress and material hardness. Due to the lack of appropriate shot media, dual laser peening is proposed for future peening optimization in C67. A novel non-destructive synchrotron radiation technique was implemented and applied for the first time for residual stress distribution analysis in gear steels with large composition and property gradients. Observed substantial residual stress redistribution and material microstructure change during the rolling contact fatigue screening test with extremely high 5.4GPa load indicates the unsuitability of the test as a fatigue life predictor. To exploit benefits of higher case hardness and associated residual stress, a new material and process (CryoForm70) aiming at 70Rc surface hardness was designed utilizing the systems approach based on thermodynamics and secondary hardening mechanisms. The composition design was first validated by the excellent agreement between experimental and theoretical core martensite start temperature in the prototype. A novel cryogenic deformation process was concurrently designed to increase the case martensite volume fraction from 76% to 92% for enhanced strengthening efficiency and surface hardness. High temperature vacuum carburizing was

Next Generation Sequencing of Ancient DNA: Requirements, Strategies and Perspectives

Directory of Open Access Journals (Sweden)

Michael Knapp

2010-07-01

Full Text Available The invention of next-generation-sequencing has revolutionized almost all fields of genetics, but few have profited from it as much as the field of ancient DNA research. From its beginnings as an interesting but rather marginal discipline, ancient DNA research is now on its way into the centre of evolutionary biology. In less than a year from its invention next-generation-sequencing had increased the amount of DNA sequence data available from extinct organisms by several orders of magnitude. Ancient DNA  research is now not only adding a temporal aspect to evolutionary studies and allowing for the observation of evolution in real time, it also provides important data to help understand the origins of our own species. Here we review progress that has been made in next-generation-sequencing of ancient DNA over the past five years and evaluate sequencing strategies and future directions.

Next Generation Safeguards Initiative: Human Capital Development

International Nuclear Information System (INIS)

Scholz, M.; Irola, G.; Glynn, K.

2015-01-01

Since 2008, the Human Capital Development (HCD) subprogramme of the U.S. National Nuclear Security Administration's (NNSA) Next Generation Safeguards Initiative (NGSI) has supported the recruitment, education, training, and retention of the next generation of international safeguards professionals to meet the needs of both the International Atomic Energy Agency (IAEA) and the United States. Specifically, HCD's efforts respond to data indicating that 82% of safeguards experts at U.S. Laboratories will have left the workforce within 15 years. This paper provides an update on the status of the subprogramme since its last presentation at the IAEA Safeguards Symposium in 2010. It highlights strengthened, integrated efforts in the areas of graduate and post-doctoral fellowships, young and midcareer professional support, short safeguards courses, and university engagement. It also discusses lessons learned from the U.S. experience in safeguards education and training as well as the importance of long-range strategies to develop a cohesive, effective, and efficient human capital development approach. (author)

WEAVE: the next generation wide-field spectroscopy facility for the William Herschel Telescope : The next generation wide-field spectroscopy facility for the William Herschel Telescope

NARCIS (Netherlands)

Dalton, Gavin; Trager, Scott C.; Abrams, Don Carlos; Carter, David; Bonifacio, Piercarlo; Aguerri, J. Alfonso L.; MacIntosh, Mike; Evans, Chris; Lewis, Ian; Navarro, Ramon; Agocs, Tibor; Dee, Kevin; Rousset, Sophie; Tosh, Ian; Middleton, Kevin; Pragt, Johannes; Terrett, David; Brock, Matthew; Benn, Chris; Verheijen, Marc; Cano Infantes, Diego; Bevil, Craige; Steele, Iain; Mottram, Chris; Bates, Stuart; Gribbin, Francis J.; Rey, Jürg; Rodriguez, Luis Fernando; Delgado, Jose Miguel; Guinouard, Isabelle; Walton, Nic; Irwin, Michael J.; Jagourel, Pascal; Stuik, Remko; Gerlofsma, Gerrit; Roelfsma, Ronald; Skillen, Ian; Ridings, Andy; Balcells, Marc; Daban, Jean-Baptiste; Gouvret, Carole; Venema, Lars; Girard, Paul

We present the preliminary design of the WEAVE next generation spectroscopy facility for the William Herschel Telescope (WHT), principally targeting optical ground-based follow up of upcoming ground-based (LOFAR) and spacebased (Gaia) surveys. WEAVE is a multi-object and multi-IFU facility utilizing

NREL-Prime Next-Generation Drivetrain Dynamometer Test Report

Energy Technology Data Exchange (ETDEWEB)

Keller, Jonathan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Erdman, Bill [Cinch, Inc., Moraga, CA (United States); Blodgett, Douglas [DNV KEMA Renewables, Burlington, VT (United States); Halse, Christopher [Romax Technology, Boulder, CO (United States)

2016-08-01

Advances in wind turbine drivetrain technologies are necessary to improve reliability and reduce the cost of energy for land-based and offshore wind turbines. The NREL-Prime Next-Generation Drivetrain team developed a geared, medium-speed drivetrain that is lighter, more reliable and more efficient than existing designs. One of the objectives of Phase II of the project was to complete the detailed design, fabrication, and dynamometer testing of a 750 kilowatt (kW) drivetrain that includes the key gearbox innovations designed by Romax Technology and power converter innovations designed by DNV Kema Renewables. The purpose of this document is to summarize these tests completed in NREL's National Wind Technology Center 2.5 megawatt (MW) dynamometer.

Impact of ectopic pregnancy for reproductive prognosis in next generation

DEFF Research Database (Denmark)

Kårhus, Line Lund; Egerup, Pia; Skovlund, Charlotte Wessel

2014-01-01

The impact of an ectopic pregnancy in the next generation is unknown. Our aim was to compare reproductive outcomes in daughters of women with and without ectopic pregnancy. Designed as a historical prospective controlled cohort study with data collected in four Danish registries from 1977-2009, w...

Prospects for next-generation e+e- linear colliders

International Nuclear Information System (INIS)

Ruth, R.D.

1990-02-01

The purpose of this paper is to review progress in the US towards a next generation linear collider. During 1988, there were three workshops held on linear colliders: ''Physics of Linear Colliders,'' in Capri, Italy, June 14--18, 1988; Snowmass 88 (Linear Collider subsection) June 27--July 15, 1988; and SLAC International Workshop on Next Generation Linear Colliders, November 28--December 9, 1988. In this paper, I focus on reviewing the issues and progress on a next generation linear collider. The energy range is dictated by physics with a mass reach well beyond LEP, although somewhat short of SSC. The luminosity is that required to obtain 10 3 --10 4 units of R 0 per year. The length is consistent with a site on Stanford land with collision occurring on the SLAC site; the power was determined by economic considerations. Finally, the technology as limited by the desire to have a next generation linear collider by the next century. 37 refs., 3 figs., 6 tabs

The DOE Next-Generation Drivetrain for Wind Turbine Applications: Gearbox, Generator, and Advanced Si/SiC Hybrid Inverter System: Preprint

Energy Technology Data Exchange (ETDEWEB)

Erdman, William; Keller, Jonathan

2016-08-01

This paper reports on the design and testing results from the U.S. Department of Energy Next-Generation Wind Turbine Drivetrain Project. The drivetrain design reduces the cost of energy by increasing energy capture through drivetrain efficiency improvements; by reducing operation and maintenance costs through reducing gearbox failures; and by lowering capital costs through weight reduction and a series of mechanical and electronic innovations. The paper provides an overview of the drivetrain gearbox and generator and provides a deeper look into the power converter system. The power converter has a number of innovations including the use of hybrid silicon (Si)/silicon carbide (SiC) isolated baseplate switching modules. Switching energies are compared between SiC and Si PIN diodes. The efficiency improvement by use of the SiC diode in a three-level converter is also described. Finally, a brief discussion covering utility interconnect requirements for turbines is provided with a particular focus on utility events that lead to high transient torque loads on drivetrain mechanical elements.

Framework for Leading Next Generation Science Standards Implementation

Science.gov (United States)

Stiles, Katherine; Mundry, Susan; DiRanna, Kathy

2017-01-01

In response to the need to develop leaders to guide the implementation of the Next Generation Science Standards (NGSS), the Carnegie Corporation of New York provided funding to WestEd to develop a framework that defines the leadership knowledge and actions needed to effectively implement the NGSS. The development of the framework entailed…

Designing Computer-Supported Complex Systems Curricula for the Next Generation Science Standards in High School Science Classrooms

Directory of Open Access Journals (Sweden)

Susan A. Yoon

2016-12-01

Full Text Available We present a curriculum and instruction framework for computer-supported teaching and learning about complex systems in high school science classrooms. This work responds to a need in K-12 science education research and practice for the articulation of design features for classroom instruction that can address the Next Generation Science Standards (NGSS recently launched in the USA. We outline the features of the framework, including curricular relevance, cognitively rich pedagogies, computational tools for teaching and learning, and the development of content expertise, and provide examples of how the framework is translated into practice. We follow this up with evidence from a preliminary study conducted with 10 teachers and 361 students, aimed at understanding the extent to which students learned from the activities. Results demonstrated gains in students’ complex systems understanding and biology content knowledge. In interviews, students identified influences of various aspects of the curriculum and instruction framework on their learning.

Next-Generation Intensity-Duration-Frequency Curves for Hydrologic Design in Snow-Dominated Environments

Energy Technology Data Exchange (ETDEWEB)

Yan, Hongxiang [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Sun, Ning [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Wigmosta, Mark [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Distinguished Faculty Fellow, Department of Civil and Environmental Engineering, University of Washington, Seattle Washington United States; Skaggs, Richard [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Hou, Zhangshuan [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Leung, Ruby [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland Washington United States

2018-02-01

There is a renewed focus on the design of infrastructure resilient to extreme hydrometeorological events. While precipitation-based intensity-duration-frequency (IDF) curves are commonly used as part of infrastructure design, a large percentage of peak runoff events in snow-dominated regions are caused by snowmelt, particularly during rain-on-snow (ROS) events. In these regions, precipitation-based IDF curves may lead to substantial over-/under-estimation of design basis events and subsequent over-/under-design of infrastructure. To overcome this deficiency, we proposed next-generation IDF (NG-IDF) curves, which characterize the actual water reaching the land surface. We compared NG-IDF curves to standard precipitation-based IDF curves for estimates of extreme events at 376 Snowpack Telemetry (SNOTEL) stations across the western United States that each had at least 30 years of high-quality records. We found standard precipitation-based IDF curves at 45% of the stations were subject to under-design, many with significant under-estimation of 100-year extreme events, for which the precipitation-based IDF curves can underestimate water potentially available for runoff by as much as 125% due to snowmelt and ROS events. The regions with the greatest potential for under-design were in the Pacific Northwest, the Sierra Nevada Mountains, and the Middle and Southern Rockies. We also found the potential for over-design at 20% of the stations, primarily in the Middle Rockies and Arizona mountains. These results demonstrate the need to consider snow processes in the development of IDF curves, and they suggest use of the more robust NG-IDF curves for hydrologic design in snow-dominated environments.

Interpretation of custom designed Illumina genotype cluster plots for targeted association studies and next-generation sequence validation

Directory of Open Access Journals (Sweden)

Tindall Elizabeth A

2010-02-01

Full Text Available Abstract Background High-throughput custom designed genotyping arrays are a valuable resource for biologically focused research studies and increasingly for validation of variation predicted by next-generation sequencing (NGS technologies. We investigate the Illumina GoldenGate chemistry using custom designed VeraCode and sentrix array matrix (SAM assays for each of these applications, respectively. We highlight applications for interpretation of Illumina generated genotype cluster plots to maximise data inclusion and reduce genotyping errors. Findings We illustrate the dramatic effect of outliers in genotype calling and data interpretation, as well as suggest simple means to avoid genotyping errors. Furthermore we present this platform as a successful method for two-cluster rare or non-autosomal variant calling. The success of high-throughput technologies to accurately call rare variants will become an essential feature for future association studies. Finally, we highlight additional advantages of the Illumina GoldenGate chemistry in generating unusually segregated cluster plots that identify potential NGS generated sequencing error resulting from minimal coverage. Conclusions We demonstrate the importance of visually inspecting genotype cluster plots generated by the Illumina software and issue warnings regarding commonly accepted quality control parameters. In addition to suggesting applications to minimise data exclusion, we propose that the Illumina cluster plots may be helpful in identifying potential in-put sequence errors, particularly important for studies to validate NGS generated variation.

Overview of NASA's Next Generation Air Transportation System (NextGen) Research

Science.gov (United States)

Swenson, Harry N.

2009-01-01

This slide presentation is an overview of the research for the Next Generation Air Transportation System (NextGen). Included is a review of the current air transportation system and the challenges of air transportation research. Also included is a review of the current research highlights and significant accomplishments.

Policy Framework for the Next Generation Platform as a Service

DEFF Research Database (Denmark)

Kentis, Angelos Mimidis; Ollora Zaballa, Eder; Soler, José

2018-01-01

The Platform-as-a-Service (PaaS) model, allows service providers to build and deploy their services following streamlined work-flows. However, platforms deployed through the PaaS model can be very diverse in terms of technologies and involved subsystems (e.g. infrastructure, orchestration). Thus,......-wide and technology-agnostic policies to NGPaaS, by means of abstraction of the underlying platforms and the use of generic interfaces. The paper also presents a specific use case for the proposed framework, which targets network-oriented policies......., the means for deploying and managing a service can significantly vary depending on the deployed platform. To address this issue, this paper proposes a policy-based framework designed for the Next Generation Platform-as-a-Service (NGPaaS). This framework allows service providers to define platform...

A two-stage flow-based intrusion detection model for next-generation networks.

Science.gov (United States)

Umer, Muhammad Fahad; Sher, Muhammad; Bi, Yaxin

2018-01-01

The next-generation network provides state-of-the-art access-independent services over converged mobile and fixed networks. Security in the converged network environment is a major challenge. Traditional packet and protocol-based intrusion detection techniques cannot be used in next-generation networks due to slow throughput, low accuracy and their inability to inspect encrypted payload. An alternative solution for protection of next-generation networks is to use network flow records for detection of malicious activity in the network traffic. The network flow records are independent of access networks and user applications. In this paper, we propose a two-stage flow-based intrusion detection system for next-generation networks. The first stage uses an enhanced unsupervised one-class support vector machine which separates malicious flows from normal network traffic. The second stage uses a self-organizing map which automatically groups malicious flows into different alert clusters. We validated the proposed approach on two flow-based datasets and obtained promising results.

Development of source term evaluation method for Korean Next Generation Reactor

Energy Technology Data Exchange (ETDEWEB)

Lee, Keon Jae; Cheong, Jae Hak; Park, Jin Baek; Kim, Guk Gee [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

1997-10-15

This project had investigate several design features of radioactive waste processing system and method to predict nuclide concentration at primary coolant basic concept of next generation reactor and safety goals at the former phase. In this project several prediction methods of source term are evaluated conglomerately and detailed contents of this project are : model evaluation of nuclide concentration at Reactor Coolant System, evaluation of primary and secondary coolant concentration of reference Nuclear Power Plant(NPP), investigation of prediction parameter of source term evaluation, basic parameter of PWR, operational parameter, respectively, radionuclide removal system and adjustment values of reference NPP, suggestion of source term prediction method of next generation NPP.

Status of the apeNEXT project

CERN Document Server

Ammendola, R.; Boucaud, Philippe; Cabibbo, N.; Di Carlo, F.; De Pietri, R.; Di Renzo, F.; Errico, W.; Fucci, A.; Guagnelli, M.; Kaldass, H.; Lonardo, A.; de Luca, S.; Micheli, J.; Morenas, V.; Pene, O.; Petronzio, R.; Palombi, F.; Pleiter, D.; Paschedag, N.; Rapuano, F.; De Riso, P.; Rossetti, D.; Salamon, A.; Salina, G.; Sartori, L.; Schifano, F.; Simma, H.; Tripiccione, R.; Vicini, P.; Boucaud, Ph.; 10.1016/S0920-5632(03)01755-9

2003-01-01

We present the current status of the apeNEXT project. Aim of this project is the development of the next generation of APE machines which will provide multi-teraflop computing power. Like previous machines, apeNEXT is based on a custom designed processor, which is specifically optimized for simulating QCD. We discuss the machine design, report on benchmarks, and give an overview on the status of the software development.

Next Generation Social Networks

DEFF Research Database (Denmark)

Sørensen, Lene Tolstrup; Skouby, Knud Erik

2008-01-01

different online networks for communities of people who share interests or individuals who presents themselves through user produced content is what makes up the social networking of today. The purpose of this paper is to discuss perceived user requirements to the next generation social networks. The paper...

Next-Generation Sequencing in the Mycology Lab.

Science.gov (United States)

Zoll, Jan; Snelders, Eveline; Verweij, Paul E; Melchers, Willem J G

New state-of-the-art techniques in sequencing offer valuable tools in both detection of mycobiota and in understanding of the molecular mechanisms of resistance against antifungal compounds and virulence. Introduction of new sequencing platform with enhanced capacity and a reduction in costs for sequence analysis provides a potential powerful tool in mycological diagnosis and research. In this review, we summarize the applications of next-generation sequencing techniques in mycology.

Architectural and Algorithmic Requirements for a Next-Generation System Analysis Code

Energy Technology Data Exchange (ETDEWEB)

V.A. Mousseau

2010-05-01

This document presents high-level architectural and system requirements for a next-generation system analysis code (NGSAC) to support reactor safety decision-making by plant operators and others, especially in the context of light water reactor plant life extension. The capabilities of NGSAC will be different from those of current-generation codes, not only because computers have evolved significantly in the generations since the current paradigm was first implemented, but because the decision-making processes that need the support of next-generation codes are very different from the decision-making processes that drove the licensing and design of the current fleet of commercial nuclear power reactors. The implications of these newer decision-making processes for NGSAC requirements are discussed, and resulting top-level goals for the NGSAC are formulated. From these goals, the general architectural and system requirements for the NGSAC are derived.

A Novel Controller Design for the Next Generation Space Electrostatic Accelerometer Based on Disturbance Observation and Rejection.

Science.gov (United States)

Li, Hongyin; Bai, Yanzheng; Hu, Ming; Luo, Yingxin; Zhou, Zebing

2016-12-23

The state-of-the-art accelerometer technology has been widely applied in space missions. The performance of the next generation accelerometer in future geodesic satellites is pushed to 8 × 10 - 13 m / s 2 / H z 1 / 2 , which is close to the hardware fundamental limit. According to the instrument noise budget, the geodesic test mass must be kept in the center of the accelerometer within the bounds of 56 pm / Hz 1 / 2 by the feedback controller. The unprecedented control requirements and necessity for the integration of calibration functions calls for a new type of control scheme with more flexibility and robustness. A novel digital controller design for the next generation electrostatic accelerometers based on disturbance observation and rejection with the well-studied Embedded Model Control (EMC) methodology is presented. The parameters are optimized automatically using a non-smooth optimization toolbox and setting a weighted H-infinity norm as the target. The precise frequency performance requirement of the accelerometer is well met during the batch auto-tuning, and a series of controllers for multiple working modes is generated. Simulation results show that the novel controller could obtain not only better disturbance rejection performance than the traditional Proportional Integral Derivative (PID) controllers, but also new instrument functions, including: easier tuning procedure, separation of measurement and control bandwidth and smooth control parameter switching.

A Novel Controller Design for the Next Generation Space Electrostatic Accelerometer Based on Disturbance Observation and Rejection

Directory of Open Access Journals (Sweden)

Hongyin Li

2016-12-01

Full Text Available The state-of-the-art accelerometer technology has been widely applied in space missions. The performance of the next generation accelerometer in future geodesic satellites is pushed to 8 × 10 − 13 m / s 2 / H z 1 / 2 , which is close to the hardware fundamental limit. According to the instrument noise budget, the geodesic test mass must be kept in the center of the accelerometer within the bounds of 56 pm / Hz 1 / 2 by the feedback controller. The unprecedented control requirements and necessity for the integration of calibration functions calls for a new type of control scheme with more flexibility and robustness. A novel digital controller design for the next generation electrostatic accelerometers based on disturbance observation and rejection with the well-studied Embedded Model Control (EMC methodology is presented. The parameters are optimized automatically using a non-smooth optimization toolbox and setting a weighted H-infinity norm as the target. The precise frequency performance requirement of the accelerometer is well met during the batch auto-tuning, and a series of controllers for multiple working modes is generated. Simulation results show that the novel controller could obtain not only better disturbance rejection performance than the traditional Proportional Integral Derivative (PID controllers, but also new instrument functions, including: easier tuning procedure, separation of measurement and control bandwidth and smooth control parameter switching.

Building next-generation converged networks theory and practice

CERN Document Server

Pathan, Al-Sakib Khan

2013-01-01

Supplying a comprehensive introduction to next-generation networks, Building Next-Generation Converged Networks: Theory and Practice strikes a balance between how and why things work and how to make them work. It compiles recent advancements along with basic issues from the wide range of fields related to next generation networks. Containing the contributions of 56 industry experts and researchers from 16 different countries, the book presents relevant theoretical frameworks and the latest research. It investigates new technologies such as IPv6 over Low Power Wireless Personal Area Network (6L

Conceptional design of a novel next-generation cryogenic stopping cell for the Low-Energy Branch of the Super-FRS

Energy Technology Data Exchange (ETDEWEB)

Dickel, T., E-mail: t.dickel@gsi.de [II. Physikalisches Institut, Justus-Liebig-Universität Gießen, Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Plaß, W.R.; Geissel, H. [II. Physikalisches Institut, Justus-Liebig-Universität Gießen, Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Heiße, F. [II. Physikalisches Institut, Justus-Liebig-Universität Gießen, Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Institut für Kern- und Teilchenphysik, Technische Universität Dresden, Dresden (Germany); Miskun, I. [II. Physikalisches Institut, Justus-Liebig-Universität Gießen, Gießen (Germany); Purushothman, S. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Reiter, M.P.; Rink, A.-K. [II. Physikalisches Institut, Justus-Liebig-Universität Gießen, Gießen (Germany); Scheidenberger, C. [II. Physikalisches Institut, Justus-Liebig-Universität Gießen, Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany)

2016-06-01

The conceptual design of a next-generation cryogenic stopping cell (CSC) for the Low-Energy Branch (LEB) of the Super-FRS has been developed. It builds on advanced techniques implemented in the prototype version of the CSC, which has recently been commissioned as part of the FRS Ion Catcher with {sup 238}U projectile and fission fragments produced at 1000 MeV/u. These techniques include cryogenic operation to ensure a high purity of the stopping gas and high-density operation enabled using an RF carpet with a small electrode structure size. The next generation CSC implements several novel concepts (e.g. perpendicular extraction) which lead to enhanced performance compared to the prototype CSC: (i) extremely short extraction times, (ii) higher rate capability, (iii) increased areal density without deteriorating extraction times, efficiencies or rate capability, (iv) minimized RF power, (v) precise range measurement of the ions and (vii) improved cleanliness of the CSC.

Next-Generation Navigational Infrastructure and the ATLAS Event Store

CERN Document Server

van Gemmeren, P; The ATLAS collaboration; Nowak, M

2014-01-01

The ATLAS event store employs a persistence framework with extensive navigational capabilities. These include real-time back navigation to upstream processing stages, externalizable data object references, navigation from any data object to any other both within a single file and across files, and more. The 2013-2014 shutdown of the Large Hadron Collider provides an opportunity to enhance this infrastructure in several ways that both extend these capabilities and allow the collaboration to better exploit emerging computing platforms. Enhancements include redesign with efficient file merging in mind, content-based indices in optimized reference types, and support for forward references. The latter provide the potential to construct valid references to data before those data are written, a capability that is useful in a variety of multithreading, multiprocessing, distributed processing, and deferred processing scenarios. This paper describes the architecture and design of the next generation of ATLAS navigation...

Next-Generation Navigational Infrastructure and the ATLAS Event Store

CERN Document Server

van Gemmeren, P; The ATLAS collaboration; Nowak, M

2013-01-01

The ATLAS event store employs a persistence framework with extensive navigational capabilities. These include real-time back navigation to upstream processing stages, externalizable data object references, navigation from any data object to any other both within a single file and across files, and more. The 2013-2014 shutdown of the Large Hadron Collider provides an opportunity to enhance this infrastructure in several ways that both extend these capabilities and allow the collaboration to better exploit emerging computing platforms. Enhancements include redesign with efficient file merging in mind, content-based indices in optimized reference types, and support for forward references. The latter provide the potential to construct valid references to data before those data are written, a capability that is useful in a variety of multithreading, multiprocessing, distributed processing, and deferred processing scenarios. This paper describes the architecture and design of the next generation of ATLAS navigation...

Next-generation navigational infrastructure and the ATLAS event store

International Nuclear Information System (INIS)

Gemmeren, P van; Malon, D; Nowak, M

2014-01-01

The ATLAS event store employs a persistence framework with extensive navigational capabilities. These include real-time back navigation to upstream processing stages, externalizable data object references, navigation from any data object to any other both within a single file and across files, and more. The 2013-2014 shutdown of the Large Hadron Collider provides an opportunity to enhance this infrastructure in several ways that both extend these capabilities and allow the collaboration to better exploit emerging computing platforms. Enhancements include redesign with efficient file merging in mind, content-based indices in optimized reference types, and support for forward references. The latter provide the potential to construct valid references to data before those data are written, a capability that is useful in a variety of multithreading, multiprocessing, distributed processing, and deferred processing scenarios. This paper describes the architecture and design of the next generation of ATLAS navigational infrastructure.

Beamstrahlung spectra in next generation linear colliders

Energy Technology Data Exchange (ETDEWEB)

Barklow, T.; Chen, P. (Stanford Linear Accelerator Center, Menlo Park, CA (United States)); Kozanecki, W. (DAPNIA-SPP, CEN-Saclay (France))

1992-04-01

For the next generation of linear colliders, the energy loss due to beamstrahlung during the collision of the e{sup +}e{sup {minus}} beams is expected to substantially influence the effective center-of-mass energy distribution of the colliding particles. In this paper, we first derive analytical formulae for the electron and photon energy spectra under multiple beamstrahlung processes, and for the e{sup +}e{sup {minus}} and {gamma}{gamma} differential luminosities. We then apply our formulation to various classes of 500 GeV e{sup +}e{sup {minus}} linear collider designs currently under study.

Using the living laboratory framework as a basis for understanding next-generation analyst work

Science.gov (United States)

McNeese, Michael D.; Mancuso, Vincent; McNeese, Nathan; Endsley, Tristan; Forster, Pete

2013-05-01

The preparation of next generation analyst work requires alternative levels of understanding and new methodological departures from the way current work transpires. Current work practices typically do not provide a comprehensive approach that emphasizes the role of and interplay between (a) cognition, (b) emergent activities in a shared situated context, and (c) collaborative teamwork. In turn, effective and efficient problem solving fails to take place, and practice is often composed of piecemeal, techno-centric tools that isolate analysts by providing rigid, limited levels of understanding of situation awareness. This coupled with the fact that many analyst activities are classified produces a challenging situation for researching such phenomena and designing and evaluating systems to support analyst cognition and teamwork. Through our work with cyber, image, and intelligence analysts we have realized that there is more required of researchers to study human-centered designs to provide for analyst's needs in a timely fashion. This paper identifies and describes how The Living Laboratory Framework can be utilized as a means to develop a comprehensive, human-centric, and problem-focused approach to next generation analyst work, design, and training. We explain how the framework is utilized for specific cases in various applied settings (e.g., crisis management analysis, image analysis, and cyber analysis) to demonstrate its value and power in addressing an area of utmost importance to our national security. Attributes of analyst work settings are delineated to suggest potential design affordances that could help improve cognitive activities and awareness. Finally, the paper puts forth a research agenda for the use of the framework for future work that will move the analyst profession in a viable manner to address the concerns identified.

The Next Generation Nuclear Plant - Insights Gained from the INEEL Point Design Studies

International Nuclear Information System (INIS)

Philip E. MacDonald; A. M. Baxter; P. D. Bayless; J. M. Bolin; H. D. Gougar; R. L. Moore; A. M. Ougouag; M. B. Richards; R. L. Sant; J. W. Sterbentz; W. K. Terry

2004-01-01

This paper provides the results of an assessment of two possible versions of the Next Generation Nuclear Plant (NGNP), a prismatic fuel type helium gas-cooled reactor and a pebble-bed fuel helium gas reactor. Insights gained regarding the strengths and weaknesses of the two designs are also discussed. Both designs will meet the three basic requirements that have been set for the NGNP: a coolant outlet temperature of 1000 C, passive safety, and a total power output consistent with that expected for commercial high-temperature gas-cooled reactors. Two major modifications of the current Gas Turbine- Modular Helium Reactor (GT-MHR) design were needed to obtain a prismatic block design with a 1000 C outlet temperature: reducing the bypass flow and better controlling the inlet coolant flow distribution to the core. The total power that could be obtained for different core heights without exceeding a peak transient fuel temperature of 1600 C during a high or low-pressure conduction cooldown event was calculated. With a coolant inlet temperature of 490 C and 10% nominal core bypass flow, it is estimated that the peak power for a 10-block high core is 686 MWt, for a 12-block high core is 786 MWt, and for a 14-block core is about 889 MWt. The core neutronics calculations showed that the NGNP will exhibit strongly negative Doppler and isothermal temperature coefficients of reactivity over the burnup cycle. In the event of rapid loss of the helium gas, there is negligible core reactivity change. However, water or steam ingress into the core coolant channels can produce a relatively large reactivity effect. Two versions of an annular pebble-bed NGNP have also been developed, a 300 and a 600 MWt module. From this work we learned how to design passively safe pebble bed reactors that produce more than 600 MWt. We also found a way to improve both the fuel utilization and safety by modifying the pebble design (by adjusting the fuel zone radius in the pebble to optimize the fuel

Next-generation sequencing offers new insights into DNA degradation

DEFF Research Database (Denmark)

Overballe-Petersen, Søren; Orlando, Ludovic Antoine Alexandre; Willerslev, Eske

2012-01-01

The processes underlying DNA degradation are central to various disciplines, including cancer research, forensics and archaeology. The sequencing of ancient DNA molecules on next-generation sequencing platforms provides direct measurements of cytosine deamination, depurination and fragmentation...... rates that previously were obtained only from extrapolations of results from in vitro kinetic experiments performed over short timescales. For example, recent next-generation sequencing of ancient DNA reveals purine bases as one of the main targets of postmortem hydrolytic damage, through base...... elimination and strand breakage. It also shows substantially increased rates of DNA base-loss at guanosine. In this review, we argue that the latter results from an electron resonance structure unique to guanosine rather than adenosine having an extra resonance structure over guanosine as previously suggested....

Designing Innovative Lessons Plans to Support the Next Generation Science Standards (NGSS)

Science.gov (United States)

Passow, M. J.

2013-12-01

The Next Generation Science Standards (NGSS) issued earlier in 2013 provide the opportunity to enhance pre-college curricula through a new focus on the ';Big Ideas' in Science, more attention to reading and writing skills needed for college and career readiness, and incorporation of engineering and technology. We introduce a set of lesson plans about scientific ocean drilling which can serve as a exemplars for developing curricula to meet NGSS approaches. Designed for middle and high school students, these can also be utilized in undergraduate courses. Development of these lessons was supported through a grant from the Deep Earth Academy of the Consortium for Ocean Leadership. They will be disseminated through websites of the Deep Earth Academy (http://www.oceanleadership.org/education/deep-earth-academy/) and Earth2Class Workshops for Teachers (http://www.earth2class.org), as well as through workshops at science education conferences sponsored by the National Earth Science Teachers Association (www.nestanet.org) and other organizations. Topics include 'Downhole Logging,' 'Age of the Ocean Floors,' 'Tales of the Resolution,' and 'Continental Shelf Sediments and Climate Change Patterns.' 'Downhole Logging' focuses on the engineering and technology utilized to obtain more information about sediments and rocks cored by the JOIDES Resolution scientific drilling vessel. 'Age of the Ocean Floor' incorporates the GeoMap App visualization tools (http://www.geomapapp.org/) to compare sea bottom materials in various parts of the world. 'Tales of the Resolution' is a series of ';graphic novels' created to describe the scientific discoveries, refitting of the JOIDES Resolution, and variety of careers available in the marine sciences (http://www.ldeo.columbia.edu/BRG/outreach/media/tales/). The fourth lesson focuses on discoveries made during Integrated Ocean Drilling Program Expedition 313, which investigated patterns in the sediments beneath the continental shelf off New

Next-generation TCAP hydrogen isotope separation process

International Nuclear Information System (INIS)

Heung, L. K.; Sessions, H. T.; Poore, A. S.; Jacobs, W. D.; Williams, C. S.

2008-01-01

A thermal cycling absorption process (TCAP) for hydrogen isotope separation has been in operation at Savannah River Site since 1994. The process uses a hot/cold nitrogen system to cycle the temperature of the separation column. The hot/cold nitrogen system requires the use of large compressors, heat exchanges, valves and piping that is bulky and maintenance intensive. A new compact thermal cycling (CTC) design has recently been developed. This new design uses liquid nitrogen tubes and electric heaters to heat and cool the column directly so that the bulky hot/cold nitrogen system can be eliminated. This CTC design is simple and is easy to implement, and will be the next generation TCAP system at SRS. A twelve-meter column has been fabricated and installed in the laboratory to demonstrate its performance. The design of the system and its test results to date is discussed. (authors)

Next Generation Germanium Systems for Safeguards Applications

International Nuclear Information System (INIS)

Dreyer, J.; Burks, M.; Hull, E.

2015-01-01

We are developing the latest generation of highly portable, mechanically cooled germanium systems for safeguard applications. In collaboration with our industrial partner, Ph.D.s Co, we have developed the Germanium Gamma Ray Imager (GeGI), an imager with a 2π field of view. This instrument has been thoroughly field tested in a wide range of environments and have performed reliably even in the harshest conditions. The imaging capability of GeGI complements existing safeguards techniques by allowing for the spatial detection, identification, and characterization of nuclear material. Additionally, imaging can be used in design information verification activities to address potential material diversions. Measurements conducted at the Paducah Gaseous Diffusion Plant highlight the advantages this instrument offers in the identification and localization of LEU, HEU and Pu holdup. GeGI has also been deployed to the Savannah River Site for the measurement of radioactive waste canisters, providing information valuable for waste characterization and inventory accountancy. Measuring 30 x 15 x 23 cm and weighing approximately 15 kg, this instrument is the first portable germanium-based imager. GeGI offers high reliability with the convenience of mechanical cooling, making this instrument ideal for the next generation of safeguards instrumentation. (author)

Next Generation Biopharmaceuticals: Product Development.

Science.gov (United States)

Mathaes, Roman; Mahler, Hanns-Christian

2018-04-11

Therapeutic proteins show a rapid market growth. The relatively young biotech industry already represents 20 % of the total global pharma market. The biotech industry environment has traditionally been fast-pasted and intellectually stimulated. Nowadays the top ten best selling drugs are dominated by monoclonal antibodies (mABs).Despite mABs being the biggest medical breakthrough in the last 25 years, technical innovation does not stand still.The goal remains to preserve the benefits of a conventional mAB (serum half-life and specificity) whilst further improving efficacy and safety and to open new and better avenues for treating patients, e.g., improving the potency of molecules, target binding, tissue penetration, tailored pharmacokinetics, and reduced adverse effects or immunogenicity.The next generation of biopharmaceuticals can pose specific chemistry, manufacturing, and control (CMC) challenges. In contrast to conventional proteins, next-generation biopharmaceuticals often require lyophilization of the final drug product to ensure storage stability over shelf-life time. In addition, next-generation biopharmaceuticals require analytical methods that cover different ways of possible degradation patterns and pathways, and product development is a long way from being straight forward. The element of "prior knowledge" does not exist equally for most novel formats compared to antibodies, and thus the assessment of critical quality attributes (CQAs) and the definition of CQA assessment criteria and specifications is difficult, especially in early-stage development.

Toward green next-generation passive optical networks

Science.gov (United States)

Srivastava, Anand

2015-01-01

Energy efficiency has become an increasingly important aspect of designing access networks, due to both increased concerns for global warming and increased network costs related to energy consumption. Comparing access, metro, and core, the access constitutes a substantial part of the per subscriber network energy consumption and is regarded as the bottleneck for increased network energy efficiency. One of the main opportunities for reducing network energy consumption lies in efficiency improvements of the customer premises equipment. Access networks in general are designed for low utilization while supporting high peak access rates. The combination of large contribution to overall network power consumption and low Utilization implies large potential for CPE power saving modes where functionality is powered off during periods of idleness. Next-generation passive optical network, which is considered one of the most promising optical access networks, has notably matured in the past few years and is envisioned to massively evolve in the near future. This trend will increase the power requirements of NG-PON and make it no longer coveted. This paper will first provide a comprehensive survey of the previously reported studies on tackling this problem. A novel solution framework is then introduced, which aims to explore the maximum design dimensions and achieve the best possible power saving while maintaining the QoS requirements for each type of service.

Rapid Conditioning for the Next Generation Melting System

Energy Technology Data Exchange (ETDEWEB)

Rue, David M. [Gas Technology Institute, Des Plaines, IL (United States)

2015-06-17

This report describes work on Rapid Conditioning for the Next Generation Melting System under US Department of Energy Contract DE-FC36-06GO16010. The project lead was the Gas Technology Institute (GTI). Partners included Owens Corning and Johns Manville. Cost share for this project was provided by NYSERDA (the New York State Energy Research and Development Authority), Owens Corning, Johns Manville, Owens Illinois, and the US natural gas industry through GTI’s SMP and UTD programs. The overreaching focus of this project was to study and develop rapid refining approaches for segmented glass manufacturing processes using high-intensity melters such as the submerged combustion melter. The objectives of this project were to 1) test and evaluate the most promising approaches to rapidly condition the homogeneous glass produced from the submerged combustion melter, and 2) to design a pilot-scale NGMS system for fiberglass recycle.

Convergence of wireless, wireline, and photonics next generation networks

CERN Document Server

Iniewski, Krzysztof

2010-01-01

Filled with illustrations and practical examples from industry, this book provides a brief but comprehensive introduction to the next-generation wireless networks that will soon replace more traditional wired technologies. Written by a mixture of top industrial experts and key academic professors, it is the only book available that covers both wireless networks (such as wireless local area and personal area networks) and optical networks (such as long-haul and metropolitan networks) in one volume. It gives engineers and engineering students the necessary knowledge to meet challenges of next-ge

Next-generation nozzle check valve significantly reduces operating costs

Energy Technology Data Exchange (ETDEWEB)

Roorda, O. [SMX International, Toronto, ON (Canada)

2009-01-15

Check valves perform an important function in preventing reverse flow and protecting plant and mechanical equipment. However, the variety of different types of valves and extreme differences in performance even within one type can change maintenance requirements and life cycle costs, amounting to millions of dollars over the typical 15-year design life of piping components. A next-generation non-slam nozzle check valve which prevents return flow has greatly reduced operating costs by protecting the mechanical equipment in a piping system. This article described the check valve varieties such as the swing check valve, a dual-plate check valve, and nozzle check valves. Advancements in optimized design of a non-slam nozzle check valve were also discussed, with particular reference to computer flow modelling such as computational fluid dynamics; computer stress modelling such as finite element analysis; and flow testing (using rapid prototype development and flow loop testing), both to improve dynamic performance and reduce hydraulic losses. The benefits of maximized dynamic performance and minimized pressure loss from the new designed valve were also outlined. It was concluded that this latest non-slam nozzle check valve design has potential applications in natural gas, liquefied natural gas, and oil pipelines, including subsea applications, as well as refineries, and petrochemical plants among others, and is suitable for horizontal and vertical installation. The result of this next-generation nozzle check valve design is not only superior performance, and effective protection of mechanical equipment but also minimized life cycle costs. 1 fig.

A survey on the human reliability analysis methods for the design of Korean next generation reactor

International Nuclear Information System (INIS)

Lee, Yong Hee; Lee, J. W.; Park, J. C.; Kwack, H. Y.; Lee, K. Y.; Park, J. K.; Kim, I. S.; Jung, K. W.

2000-03-01

Enhanced features through applying recent domestic technologies may characterize the safety and efficiency of KNGR(Korea Next Generation Reactor). Human engineered interface and control room environment are expected to be beneficial to the human aspects of KNGR design. However, since the current method for human reliability analysis is not up to date after THERP/SHARP, it becomes hard to assess the potential of human errors due to both of the positive and negative effect of the design changes in KNGR. This is a state of the art report on the human reliability analysis methods that are potentially available for the application to the KNGR design. We surveyed every technical aspects of existing HRA methods, and compared them in order to obtain the requirements for the assessment of human error potentials within KNGR design. We categorized the more than 10 methods into the first and the second generation according to the suggestion of Dr. Hollnagel. THERP was revisited in detail. ATHEANA proposed by US NRC for an advanced design and CREAM proposed by Dr. Hollnagel were reviewed and compared. We conclude that the key requirements might include the enhancement in the early steps for human error identification and the quantification steps with considerations of more extended error shaping factors over PSFs(performance shaping factors). The utilization of the steps and approaches of ATHEANA and CREAM will be beneficial to the attainment of an appropriate HRA method for KNGR. However, the steps and data from THERP will be still maintained because of the continuity with previous PSA activities in KNGR design

A survey on the human reliability analysis methods for the design of Korean next generation reactor

Energy Technology Data Exchange (ETDEWEB)

Lee, Yong Hee; Lee, J. W.; Park, J. C.; Kwack, H. Y.; Lee, K. Y.; Park, J. K.; Kim, I. S.; Jung, K. W

2000-03-01

Enhanced features through applying recent domestic technologies may characterize the safety and efficiency of KNGR(Korea Next Generation Reactor). Human engineered interface and control room environment are expected to be beneficial to the human aspects of KNGR design. However, since the current method for human reliability analysis is not up to date after THERP/SHARP, it becomes hard to assess the potential of human errors due to both of the positive and negative effect of the design changes in KNGR. This is a state of the art report on the human reliability analysis methods that are potentially available for the application to the KNGR design. We surveyed every technical aspects of existing HRA methods, and compared them in order to obtain the requirements for the assessment of human error potentials within KNGR design. We categorized the more than 10 methods into the first and the second generation according to the suggestion of Dr. Hollnagel. THERP was revisited in detail. ATHEANA proposed by US NRC for an advanced design and CREAM proposed by Dr. Hollnagel were reviewed and compared. We conclude that the key requirements might include the enhancement in the early steps for human error identification and the quantification steps with considerations of more extended error shaping factors over PSFs(performance shaping factors). The utilization of the steps and approaches of ATHEANA and CREAM will be beneficial to the attainment of an appropriate HRA method for KNGR. However, the steps and data from THERP will be still maintained because of the continuity with previous PSA activities in KNGR design.

Candu technology: the next generation now

International Nuclear Information System (INIS)

Hopwood, J.M.; Duffey, R.B.; Torgerson, D.F.

2001-01-01

We describe the development philosophy, direction and concepts that are being utilized by AECL to refine the CANDU reactor to meet the needs of current and future competitive energy markets. The technology development path for CANDU reactors is based on the optimization of the pressure tube concept. Because of the inherent modularity and flexibility of this basis for the core design, it is possible to provide a seamless and continuous evolution of the reactor design and performance. There is no need for a drastic shift in concept, in technology or in fuel. By continual refinement of the flow and materials conditions in the channels, the basic reactor can be thermally and operationally efficient, highly competitive and economic, and highly flexible in application. Thus, the design can build on the successful construction and operating experience of the existing plants, and no step changes in development direction are needed. This approach minimizes investor, operator and development risk but still provides technological, safety and performance advances. In today's world energy markets, major drivers for the technology development are: (a) reduced capital cost; (b) improved operation; (c) enhanced safety; and (d) fuel cycle flexibility. The drivers provide specific numerical targets. Meeting these drivers ensures that the concept meets and exceeds the customer economic, performance, safety and resource use goals and requirements, including the suitable national and international standards. This logical development of the CANDU concept leads naturally to the 'Next Generation' of CANDU reactors. The major features under development include an optimized lattice for SEU (slightly enriched uranium) fuel, light water cooling coupled with heavy water moderation, advanced fuel channels and CANFLEX fuel, optimization of plant performance, enhanced thermal and BOP (balance of plant) efficiency, and the adoption of layout and construction technology adapted from successful on

JVM: Java Visual Mapping tool for next generation sequencing read.

Science.gov (United States)

Yang, Ye; Liu, Juan

2015-01-01

We developed a program JVM (Java Visual Mapping) for mapping next generation sequencing read to reference sequence. The program is implemented in Java and is designed to deal with millions of short read generated by sequence alignment using the Illumina sequencing technology. It employs seed index strategy and octal encoding operations for sequence alignments. JVM is useful for DNA-Seq, RNA-Seq when dealing with single-end resequencing. JVM is a desktop application, which supports reads capacity from 1 MB to 10 GB.

Economic factors for the next generation NPPs

International Nuclear Information System (INIS)

Bengt, I.; Matzie, R.A.

1996-01-01

This paper has summarized the major economic factors that will impact the economic viability of the next generation of nuclear power plants. To make these plants competitive with other sources of electric power, they must have a large plant output (1000 - 1400 M We), be constructed over a short time period (on the order of four years or less), be standardized designs which are pre-licensed, and achieve high availability through the use of long operating cycles and short refueling outages. Many features in the design of these plants can promote these attributes. This is the task of the designer in concert with the plant constructor and equipment supplier to work in a concurrent manner to obtain an integrated design that achieves these goals. It is important from the beginning that all interested parties recognize that there must be a balance between the desire for improved safety and the cost to achieve this safety. Similarly, there must be a recognition that the economics of nuclear power plants are based on power generation costs over a sixty year period, not on the initial capital cost of the plant. The initial capital cost of the plant is only about one-third of the total cost of running the plant for its life time. Thus, focusing on the initial capital costs may drive the designers to incorporate features that adversely affect its future operation. Features such as compact plant designs that have restricted access to components, and the use of highly interconnected systems that perform multiple functions, result in increased difficulty of operating and maintaining the plant. Exhaustive planning in all phases of the plant life cycle will reap dramatic dividends in the reduction of power generation costs. The planning done in the design phase by utilizing designers, constructors, and operators will result in a plant that has lower power generation costs. Planning during the construction phase can result in a shorter schedule, by eliminating essentially all rework

Next-Generation Intensity-Duration-Frequency Curves for Hydrologic Design in Snow-Dominated Environments

Science.gov (United States)

Yan, Hongxiang; Sun, Ning; Wigmosta, Mark; Skaggs, Richard; Hou, Zhangshuan; Leung, Ruby

2018-02-01

There is a renewed focus on the design of infrastructure resilient to extreme hydrometeorological events. While precipitation-based intensity-duration-frequency (IDF) curves are commonly used as part of infrastructure design, a large percentage of peak runoff events in snow-dominated regions are caused by snowmelt, particularly during rain-on-snow (ROS) events. In these regions, precipitation-based IDF curves may lead to substantial overestimation/underestimation of design basis events and subsequent overdesign/underdesign of infrastructure. To overcome this deficiency, we proposed next-generation IDF (NG-IDF) curves, which characterize the actual water reaching the land surface. We compared NG-IDF curves to standard precipitation-based IDF curves for estimates of extreme events at 376 Snowpack Telemetry (SNOTEL) stations across the western United States that each had at least 30 years of high-quality records. We found standard precipitation-based IDF curves at 45% of the stations were subject to underdesign, many with significant underestimation of 100 year extreme events, for which the precipitation-based IDF curves can underestimate water potentially available for runoff by as much as 125% due to snowmelt and ROS events. The regions with the greatest potential for underdesign were in the Pacific Northwest, the Sierra Nevada Mountains, and the Middle and Southern Rockies. We also found the potential for overdesign at 20% of the stations, primarily in the Middle Rockies and Arizona mountains. These results demonstrate the need to consider snow processes in the development of IDF curves, and they suggest use of the more robust NG-IDF curves for hydrologic design in snow-dominated environments.

Recent progress in nanostructured next-generation field emission devices

International Nuclear Information System (INIS)

Mittal, Gaurav; Lahiri, Indranil

2014-01-01

Field emission has been known to mankind for more than a century, and extensive research in this field for the last 40–50 years has led to development of exciting applications such as electron sources, miniature x-ray devices, display materials, etc. In the last decade, large-area field emitters were projected as an important material to revolutionize healthcare and medical devices, and space research. With the advent of nanotechnology and advancements related to carbon nanotubes, field emitters are demonstrating highly enhanced performance and novel applications. Next-generation emitters need ultra-high emission current density, high brightness, excellent stability and reproducible performance. Novel design considerations and application of new materials can lead to achievement of these capabilities. This article presents an overview of recent developments in this field and their effects on improved performance of field emitters. These advancements are demonstrated to hold great potential for application in next-generation field emission devices. (topical review)

Recent progress in nanostructured next-generation field emission devices

Science.gov (United States)

Mittal, Gaurav; Lahiri, Indranil

2014-08-01

Field emission has been known to mankind for more than a century, and extensive research in this field for the last 40-50 years has led to development of exciting applications such as electron sources, miniature x-ray devices, display materials, etc. In the last decade, large-area field emitters were projected as an important material to revolutionize healthcare and medical devices, and space research. With the advent of nanotechnology and advancements related to carbon nanotubes, field emitters are demonstrating highly enhanced performance and novel applications. Next-generation emitters need ultra-high emission current density, high brightness, excellent stability and reproducible performance. Novel design considerations and application of new materials can lead to achievement of these capabilities. This article presents an overview of recent developments in this field and their effects on improved performance of field emitters. These advancements are demonstrated to hold great potential for application in next-generation field emission devices.

Development of technology for next generation reactor - Research of evaluation technology for nuclear power plant -

Energy Technology Data Exchange (ETDEWEB)

Park, Jong Kyun; Chang, Moon Heuy; Hwang, Yung Dong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)] [and others

1993-09-01

For development of next generation reactor, a project for evaluation technology for nuclear power plant is performed. Evaluation technology is essential to next generation reactor for reactor safety and system analysis. For design concept, detailed evaluation technologies are studied as follows: evaluation of safety margin, evaluation of safety facilities, evaluation of measurement and control technology; man-machine interface. Especially for thermal efficiency, thermal properties and chemical composition of inconel 690 tube, instead of inconel 600 tube, are measured for steam generator. (Author).

A Design of Solar Proton Telescope for Next Generation Small Satellite

Directory of Open Access Journals (Sweden)

Jongdae Sohn

2012-12-01

Full Text Available The solar proton telescope (SPT is considered as one of the scientific instruments to be installed in instruments for the study of space storm (ISSS which is determined for next generation small satellite-1 (NEXTSat-1. The SPT is the instrument that acquires the information on energetic particles, especially the energy and flux of proton, according to the solar activity in the space radiation environment. We performed the simulation to determine the specification of the SPT using geometry and tracking 4 (GEANT4. The simulation was performed in the range of 0.6-1,000 MeV considering that the proton, which is to be detected, corresponds to the high energy region according to the solar activity in the space radiation environment. By using aluminum as a blocking material and adjusting the energy detection range, we determined total 7 channels (0.6~5, 5~10, 10~20, 20~35, 35~52, 52~72, and >72 MeV for the energy range of SPT. In the SPT, the proton energy was distinguished using linear energy transfer to compare with or discriminate from relativistic electron for the channels P1-P3 which are the range of less than 20 MeV, and above those channels, the energy was determined on the basis of whether silicon semiconductor detector (SSD signal can pass or not. To determine the optimal channel, we performed the conceptual design of payload which uses the SSD. The designed SPT will improve the understanding on the capture and decline of solar energetic particles at the radiation belt by measuring the energetic proton.

DARC: Next generation decentralized control framework for robot applications

DEFF Research Database (Denmark)

Kjærgaard, Morten; Andersen, Nils Axel; Ravn, Ole

2013-01-01

This paper presents DARC, a next generation control framework for robot applications. It is designed to be equally powerful in prototyping research projects and for building serious commercial robots running on low powered embedded hardware, thus closing the gab between research and industry....... It incorporates several new techniques such as a decentralized peer-to-peer architecture, transparent network distribution of the control system, and automatic run-time supervision to guarantee robustness....

Next Generation Summer School

Science.gov (United States)

Eugenia, Marcu

2013-04-01

On 21.06.2010 the "Next Generation" Summer School has opened the doors for its first students. They were introduced in the astronomy world by astronomical observations, astronomy and radio-astronomy lectures, laboratory projects meant to initiate them into modern radio astronomy and radio communications. The didactic programme was structure as fallowing: 1) Astronomical elements from the visible spectrum (lectures + practical projects) 2) Radio astronomy elements (lectures + practical projects) 3) Radio communication base (didactic- recreative games) The students and professors accommodation was at the Agroturistic Pension "Popasul Iancului" situated at 800m from the Marisel Observatory. First day (summer solstice day) began with a practical activity: determination of the meridian by measurements of the shadow (the direction of one vertical alignment, when it has the smallest length). The experiment is very instructive and interesting because combines notions of physics, spatial geometry and basic astronomy elements. Next day the activities took place in four stages: the students processed the experimental data obtained on first day (on sheets of millimetre paper they represented the length of the shadow alignments according the time), each team realised its own sun quadrant, point were given considering the design and functionality of these quadrant, the four teams had to mimic important constellations on carton boards with phosphorescent sticky stars and the students, accompanied by the professors took a hiking trip to the surroundings, marking the interest point coordinates, using a GPS to establish the geographical coronations and at the end of the day the students realised a small map of central Marisel area based on the GPS data. On the third day, the students were introduced to basic notions of radio astronomy, the principal categories of artificial Earth satellites: low orbit satellites (LEO), Medium orbit satellites (MEO) and geostationary satellites (GEO

Forecasting the Commercial Attractiveness of User-Generated Designs Using Online Data

DEFF Research Database (Denmark)

Jensen, Morten Berg; Hienerth, Christoph; Lettl, Christopher

2014-01-01

workload in the selection phase by predicting which user-generated designs it would most likely perceive as commercially attractive. Prior research emphasizes that among the vast amount of ideas generated in online user communities, it is the lead users’ ideas that tend to stick out in terms of commercial...... attractiveness. Our paper aims to provide the next step by developing a heuristic for filtering commercially attractive ideas that are generated in online user communities. Therefore, prior lead user research is used as a point of reference for our study. This research stream has produced rich insights......-generated designs. We find an inverted U-shaped relationship between the complexity of a user-generated design and its perceived commercial attractiveness. Furthermore, we find a positive relationship between the positive feedback received by a given user-generated design within the peer community and its perceived...

Two-Dimensional Metal Oxide Nanomaterials for Next-Generation Rechargeable Batteries.

Science.gov (United States)

Mei, Jun; Liao, Ting; Kou, Liangzhi; Sun, Ziqi

2017-12-01

The exponential increase in research focused on two-dimensional (2D) metal oxides has offered an unprecedented opportunity for their use in energy conversion and storage devices, especially for promising next-generation rechargeable batteries, such as lithium-ion batteries (LIBs) and sodium-ion batteries (NIBs), as well as some post-lithium batteries, including lithium-sulfur batteries, lithium-air batteries, etc. The introduction of well-designed 2D metal oxide nanomaterials into next-generation rechargeable batteries has significantly enhanced the performance of these energy-storage devices by providing higher chemically active interfaces, shortened ion-diffusion lengths, and improved in-plane carrier-/charge-transport kinetics, which have greatly promoted the development of nanotechnology and the practical application of rechargeable batteries. Here, the recent progress in the application of 2D metal oxide nanomaterials in a series of rechargeable LIBs, NIBs, and other post lithium-ion batteries is reviewed relatively comprehensively. Current opportunities and future challenges for the application of 2D nanomaterials in energy-storage devices to achieve high energy density, high power density, stable cyclability, etc. are summarized and outlined. It is believed that the integration of 2D metal oxide nanomaterials in these clean energy devices offers great opportunities to address challenges driven by increasing global energy demands. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Composite Materials under Extreme Radiation and Temperature Environments of the Next Generation Nuclear Reactors

International Nuclear Information System (INIS)

Simos, N.

2011-01-01

operating envelope of both fission and fusion reactors. In advanced fission reactors composite materials are being designed in an effort to extend the life and improve the reliability of fuel rod cladding as well as structural materials. Composites are being considered for use as core internals in the next generation of gas-cooled reactors. Further, next-generation plasma-fusion reactors, such as the International Thermonuclear Experimental Reactor (ITER) will rely on the capabilities of advanced composites to safely withstand extremely high neutron fluxes while providing superior thermal shock resistance.

NextGEOSS: The Next Generation Data Hub For Earth Observations

Science.gov (United States)

Lilja Bye, Bente; De Lathouwer, Bart; Catarino, Nuno; Concalves, Pedro; Trijssenaar, Nicky; Grosso, Nuno; Meyer-Arnek, Julian; Goor, Erwin

2017-04-01

The Group on Earth observation embarked on the next 10 year phase with an ambition to streamline and further develop its achievements in building the Global Earth Observing System of Systems (GEOSS). The NextGEOSS project evolves the European vision of GEOSS data exploitation for innovation and business, relying on the three main pillars of engaging communities, delivering technological developments and advocating the use of GEOSS, in order to support the creation and deployment of Earth observation based innovative research activities and commercial services. In this presentation we will present the NextGEOSS concept, a concept that revolves around providing the data and resources to the users communities, together with Cloud resources, seamlessly connected to provide an integrated ecosystem for supporting applications. A central component of NextGEOSS is the strong emphasis put on engaging the communities of providers and users, and bridging the space in between.

StarTrax --- The Next Generation User Interface

Science.gov (United States)

Richmond, Alan; White, Nick

StarTrax is a software package to be distributed to end users for installation on their local computing infrastructure. It will provide access to many services of the HEASARC, i.e. bulletins, catalogs, proposal and analysis tools, initially for the ROSAT MIPS (Mission Information and Planning System), later for the Next Generation Browse. A user activating the GUI will reach all HEASARC capabilities through a uniform view of the system, independent of the local computing environment and of the networking method of accessing StarTrax. Use it if you prefer the point-and-click metaphor of modern GUI technology, to the classical command-line interfaces (CLI). Notable strengths include: easy to use; excellent portability; very robust server support; feedback button on every dialog; painstakingly crafted User Guide. It is designed to support a large number of input devices including terminals, workstations and personal computers. XVT's Portability Toolkit is used to build the GUI in C/C++ to run on: OSF/Motif (UNIX or VMS), OPEN LOOK (UNIX), or Macintosh, or MS-Windows (DOS), or character systems.

The Next-Generation Very Large Array: Technical Overview

Science.gov (United States)

McKinnon, Mark; Selina, Rob

2018-01-01

As part of its mandate as a national observatory, the NRAO is looking toward the long range future of radio astronomy and fostering the long term growth of the US astronomical community. NRAO has sponsored a series of science and technical community meetings to consider the science mission and design of a next-generation Very Large Array (ngVLA), building on the legacies of the Atacama Large Millimeter/submillimeter Array (ALMA) and the Very Large Array (VLA).The basic ngVLA design emerging from these discussions is an interferometric array with approximately ten times the sensitivity and ten times higher spatial resolution than the VLA and ALMA radio telescopes, optimized for operation in the wavelength range 0.3cm to 3cm. The ngVLA would open a new window on the Universe through ultra-sensitive imaging of thermal line and continuum emission down to milli-arcsecond resolution, as well as unprecedented broadband continuum polarimetric imaging of non-thermal processes. The specifications and concepts for major ngVLA system elements are rapidly converging.We will provide an overview of the current system design of the ngVLA. The concepts for major system elements such as the antenna, receiving electronics, and central signal processing will be presented. We will also describe the major development activities that are presently underway to advance the design.

Next generation of relativistic heavy ion accelerators

International Nuclear Information System (INIS)

Grunder, H.; Leemann, C.; Selph, F.

1978-06-01

Results are presented of exploratory and preliminary studies of a next generation of heavy ion accelerators. The conclusion is reached that useful luminosities are feasible in a colliding beam facility for relativistic heavy ions. Such an accelerator complex may be laid out in such a way as to provide extractebeams for fixed target operation, therefore allowing experimentation in an energy region overlapping with that presently available. These dual goals seem achievable without undue complications, or penalties with respect to cost and/or performance

Real-Time Optimization and Control of Next-Generation Distribution

Science.gov (United States)

-Generation Distribution Infrastructure Real-Time Optimization and Control of Next-Generation Distribution developing a system-theoretic distribution network management framework that unifies real-time voltage and Infrastructure | Grid Modernization | NREL Real-Time Optimization and Control of Next

Hacking the next generation

CERN Document Server

Dhanjani, Nitesh; Hardin, Brett

2009-01-01

With the advent of rich Internet applications, the explosion of social media, and the increased use of powerful cloud computing infrastructures, a new generation of attackers has added cunning new techniques to its arsenal. For anyone involved in defending an application or a network of systems, Hacking: The Next Generation is one of the few books to identify a variety of emerging attack vectors. You'll not only find valuable information on new hacks that attempt to exploit technical flaws, you'll also learn how attackers take advantage of individuals via social networking sites, and abuse

Diagnostics of Primary Immunodeficiencies through Next Generation Sequencing

Directory of Open Access Journals (Sweden)

Vera Gallo

2016-11-01

Full Text Available Background: Recently, a growing number of novel genetic defects underlying primary immunodeficiencies (PID have been identified, increasing the number of PID up to more than 250 well-defined forms. Next-generation sequencing (NGS technologies and proper filtering strategies greatly contributed to this rapid evolution, providing the possibility to rapidly and simultaneously analyze large numbers of genes or the whole exome. Objective: To evaluate the role of targeted next-generation sequencing and whole exome sequencing in the diagnosis of a case series, characterized by complex or atypical clinical features suggesting a PID, difficult to diagnose using the current diagnostic procedures.Methods: We retrospectively analyzed genetic variants identified through targeted next-generation sequencing or whole exome sequencing in 45 patients with complex PID of unknown etiology. Results: 40 variants were identified using targeted next-generation sequencing, while 5 were identified using whole exome sequencing. Newly identified genetic variants were classified into 4 groups: I variations associated with a well-defined PID; II variations associated with atypical features of a well-defined PID; III functionally relevant variations potentially involved in the immunological features; IV non-diagnostic genotype, in whom the link with phenotype is missing. We reached a conclusive genetic diagnosis in 7/45 patients (~16%. Among them, 4 patients presented with a typical well-defined PID. In the remaining 3 cases, mutations were associated with unexpected clinical features, expanding the phenotypic spectrum of typical PIDs. In addition, we identified 31 variants in 10 patients with complex phenotype, individually not causative per se of the disorder.Conclusion: NGS technologies represent a cost-effective and rapid first-line genetic approaches for the evaluation of complex PIDs. Whole exome sequencing, despite a moderate higher cost compared to targeted, is

Traffic Management for Next Generation Transport Networks

DEFF Research Database (Denmark)

Yu, Hao

required by the next generation transport network to provide Quality-of-Service (QoS) guaranteed video services. Augmenting network capacity and upgrading network nodes indicate long deployment period, replacement of equipment and thus significant cost to the network service providers. This challenge may...... slacken the steps of some network operators towards providing IPTV services. In this dissertation, the topology-based hierarchical scheduling scheme is proposed to tackle the problem addressed. The scheme simplifies the deployment process by placing an intelligent switch with centralized traffic...... management functions at the edge of the network, scheduling traffic on behalf of the other nodes. The topology-based hierarchical scheduling scheme is able to provide outstanding flow isolation due to its centralized scheduling ability, which is essential for providing IPTV services. In order to reduce...

A next generation field-portable goniometer system

Science.gov (United States)

Harms, Justin D.; Bachmann, Charles M.; Faulring, Jason W.; Ruiz Torres, Andres J.

2016-05-01

Various field portable goniometers have been designed to capture in-situ measurements of a materials bi-directional reflectance distribution function (BRDF), each with a specific scientific purpose in mind.1-4 The Rochester Institute of Technology's (RIT) Chester F. Carlson Center for Imaging Science recently created a novel instrument incorporating a wide variety of features into one compact apparatus in order to obtain very high accuracy BRDFs of short vegetation and sediments, even in undesirable conditions and austere environments. This next generation system integrates a dual-view design using two VNIR/SWIR pectroradiometers to capture target reflected radiance, as well as incoming radiance, to provide for better optical accuracy when measuring in non-ideal atmospheric conditions or when background illumination effects are non-negligible. The new, fully automated device also features a laser range finder to construct a surface roughness model of the target being measured, which enables the user to include inclination information into BRDF post-processing and further allows for roughness effects to be better studied for radiative transfer modeling. The highly portable design features automatic leveling, a precision engineered frame, and a variable measurement plane that allow for BRDF measurements on rugged, un-even terrain while still maintaining true angular measurements with respect to the target, all without sacrificing measurement speed. Despite the expanded capabilities and dual sensor suite, the system weighs less than 75 kg, which allows for excellent mobility and data collection on soft, silty clay or fine sand.

Rhamnolipids--next generation surfactants?

Science.gov (United States)

Müller, Markus Michael; Kügler, Johannes H; Henkel, Marius; Gerlitzki, Melanie; Hörmann, Barbara; Pöhnlein, Martin; Syldatk, Christoph; Hausmann, Rudolf

2012-12-31

The demand for bio-based processes and materials in the petrochemical industry has significantly increased during the last decade because of the expected running out of petroleum. This trend can be ascribed to three main causes: (1) the increased use of renewable resources for chemical synthesis of already established product classes, (2) the replacement of chemical synthesis of already established product classes by new biotechnological processes based on renewable resources, and (3) the biotechnological production of new molecules with new features or better performances than already established comparable chemically synthesized products. All three approaches are currently being pursued for surfactant production. Biosurfactants are a very promising and interesting substance class because they are based on renewable resources, sustainable, and biologically degradable. Alkyl polyglycosides are chemically synthesized biosurfactants established on the surfactant market. The first microbiological biosurfactants on the market were sophorolipids. Of all currently known biosurfactants, rhamnolipids have the highest potential for becoming the next generation of biosurfactants introduced on the market. Although the metabolic pathways and genetic regulation of biosynthesis are known qualitatively, the quantitative understanding relevant for bioreactor cultivation is still missing. Additionally, high product titers have been exclusively described with vegetable oil as sole carbon source in combination with Pseudomonas aeruginosa strains. Competitive productivity is still out of reach for heterologous hosts or non-pathogenic natural producer strains. Thus, on the one hand there is a need to gain a deeper understanding of the regulation of rhamnolipid production on process and cellular level during bioreactor cultivations. On the other hand, there is a need for metabolizable renewable substrates, which do not compete with food and feed. A sustainable bioeconomy approach should

Identification and Characterization of Key Human Performance Issues and Research in the Next Generation Air Transportation System (NextGen)

Science.gov (United States)

Lee, Paul U.; Sheridan, Tom; Poage, james L.; Martin, Lynne Hazel; Jobe, Kimberly K.

2010-01-01

This report identifies key human-performance-related issues associated with Next Generation Air Transportation System (NextGen) research in the NASA NextGen-Airspace Project. Four Research Focus Areas (RFAs) in the NextGen-Airspace Project - namely Separation Assurance (SA), Airspace Super Density Operations (ASDO), Traffic Flow Management (TFM), and Dynamic Airspace Configuration (DAC) - were examined closely. In the course of the research, it was determined that the identified human performance issues needed to be analyzed in the context of NextGen operations rather than through basic human factors research. The main gaps in human factors research in NextGen were found in the need for accurate identification of key human-systems related issues within the context of specific NextGen concepts and better design of the operational requirements for those concepts. By focusing on human-system related issues for individual concepts, key human performance issues for the four RFAs were identified and described in this report. In addition, mixed equipage airspace with components of two RFAs were characterized to illustrate potential human performance issues that arise from the integration of multiple concepts.

Physical Configuration of the Next Generation Home Network

Science.gov (United States)

Terada, Shohei; Kakishima, Yu; Hanawa, Dai; Oguchi, Kimio

The number of broadband users is rapidly increasing worldwide. Japan already has over 10 million FTTH users. Another trend is the rapid digitalization of home electrical equipment e. g. digital cameras and hard disc recorders. These trends will encourage the emergence of the next generation home network. In this paper, we introduce the next generation home network image and describe the five domains into which home devices can be classified. We then clarify the optimum medium with which to configure the network given the requirements imposed by the home environment. Wiring cable lengths for three network topologies are calculated. The results gained from the next generation home network implemented on the first phase testbed are shown. Finally, our conclusions are given.

Status of advanced containment systems for next generation water reactors

International Nuclear Information System (INIS)

1994-06-01

The present IAEA status report is intended to provide information on the current status and development of containment systems of the next generation reactors for electricity production and, particularly, to highlight features which may be considered advanced, i.e. which present improved performance with evolutionary or innovative design solutions or new design approaches. The objectives of the present status report are: To present, on a concise and consistent basis, selected containment designs currently being developed in the world; to review and compare new approaches to the design bases for the containments, in order to identify common trends, that may eventually lead to greater worldwide consensus, to identify, list and compare existing design objectives for advanced containments, related to safety, availability, maintainability, plant life, decommissioning, economics, etc.; to describe the general approaches adopted in different advanced containments to cope with various identified challenges, both those included in the current design bases and those related to new events considered in the design; to briefly identify recent achievements and future needs for new or improved computer codes, standards, experimental research, prototype testing, etc. related to containment systems; to describe the outstanding features of some containments or specific solutions proposed by different parties and which are generally interesting to the international scientific community. 36 refs, 27 figs, 1 tab

The DIAN-TU Next Generation Alzheimer’s prevention trial: adaptive design and disease progression model

Science.gov (United States)

Bateman, Randall J.; Benzinger, Tammie L.; Berry, Scott; Clifford, David B.; Duggan, Cynthia; Fagan, Anne M.; Fanning, Kathleen; Farlow, Martin R.; Hassenstab, Jason; McDade, Eric M.; Mills, Susan; Paumier, Katrina; Quintana, Melanie; Salloway, Stephen P.; Santacruz, Anna; Schneider, Lon S.; Wang, Guoqiao; Xiong, Chengjie

2016-01-01

INTRODUCTION The Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) trial is an adaptive platform trial testing multiple drugs to slow or prevent the progression of Alzheimer’s disease in autosomal dominant Alzheimer’s disease (ADAD) families. With completion of enrollment of the first two drug arms, the DIAN-TU now plans to add new drugs to the platform, designated as the Next Generation Prevention Trial (NexGen). METHODS In collaboration with ADAD families, philanthropic organizations, academic leaders, the DIAN-TU Pharma Consortium, the NIH, and regulatory colleagues, the DIAN-TU developed innovative clinical study designs for the DIAN-TU NexGen trial. RESULTS Our expanded trials toolbox consists of a Disease Progression Model for ADAD, primary endpoint DIAN-TU cognitive performance composite, biomarker development, self-administered cognitive assessments, adaptive dose adjustments, and blinded data collection through the last participant completion. CONCLUSION These steps represent elements to improve efficacy of the adaptive platform trial and a continued effort to optimize prevention and treatment trials in ADAD. PMID:27583651

Safety criteria for the next generation of European reactors

International Nuclear Information System (INIS)

Dominguez Bautista, M.T.

1995-01-01

For the next generation of reactors, European companies operating in the electricity sector have drawn up a document called European Utilities Requirement (EUR), which sets out the requirements to be met by the designers of future reactors. The main objective of these new requirements is to increase the safety in existing reactors, making good use of operating experience available and the technological developments of the last decade. This paper offers an in-depth analysis of the most significant characteristics, describing how the EUR requirements have been prepared and how they are being implemented by the designers. Areas covered are: - Combining deterministic and probabilistic criteria - Automation of control systems - Design extension for severe accidents - Containment design - Emergency plans - Autonomy versus manual operation

Next Generation Nuclear Plant Materials Research and Development Program Plan

Energy Technology Data Exchange (ETDEWEB)

G. O. Hayner; E.L. Shaber

2004-09-01

The U.S Department of Energy (DOE) has selected the Very High Temperature Reactor (VHTR) design for the Next Generation Nuclear Plant (NGNP) Project. The NGNP will demonstrate the use of nuclear power for electricity and hydrogen production without greenhouse gas emissions. The reactor design will be a graphite moderated, helium-cooled, prismatic or pebble-bed, thermal neutron spectrum reactor that will produce electricity and hydrogen in a state-of-the-art thermodynamically efficient manner. The NGNP will use very high burn-up, low-enriched uranium, TRISO-coated fuel and have a projected plant design service life of 60 years.

Next Generation Nuclear Plant Materials Selection and Qualification Program Plan

Energy Technology Data Exchange (ETDEWEB)

R. Doug Hamelin; G. O. Hayner

2004-11-01

The U.S. Department of Energy (DOE) has selected the Very High Temperature Reactor (VHTR) design for the Next Generation Nuclear Plant (NGNP) Project. The NGNP will demonstrate the use of nuclear power for electricity and hydrogen production without greenhouse gas emissions. The reactor design is a graphite-moderated, helium-cooled, prismatic or pebble bed thermal neutron spectrum reactor with an average reactor outlet temperature of at least 1000 C. The NGNP will use very high burn up, lowenriched uranium, TRISO-Coated fuel in a once-through fuel cycle. The design service life of the NGNP is 60 years.

Beamstrahlung spectra in next generation linear colliders. Revision

Energy Technology Data Exchange (ETDEWEB)

Barklow, T.; Chen, P. [Stanford Linear Accelerator Center, Menlo Park, CA (United States); Kozanecki, W. [DAPNIA-SPP, CEN-Saclay (France)

1992-04-01

For the next generation of linear colliders, the energy loss due to beamstrahlung during the collision of the e{sup +}e{sup {minus}} beams is expected to substantially influence the effective center-of-mass energy distribution of the colliding particles. In this paper, we first derive analytical formulae for the electron and photon energy spectra under multiple beamstrahlung processes, and for the e{sup +}e{sup {minus}} and {gamma}{gamma} differential luminosities. We then apply our formulation to various classes of 500 GeV e{sup +}e{sup {minus}} linear collider designs currently under study.

Carrier ethernet network control plane based on the Next Generation Network

DEFF Research Database (Denmark)

Fu, Rong; Wang, Yanmeng; Berger, Michael Stubert

2008-01-01

This paper contributes on presenting a step towards the realization of Carrier Ethernet control plane based on the next generation network (NGN). Specifically, transport MPLS (T-MPLS) is taken as the transport technology in Carrier Ethernet. It begins with providing an overview of the evolving...... architecture of the next generation network (NGN). As an essential candidate among the NGN transport technologies, the definition of Carrier Ethernet (CE) is also introduced here. The second part of this paper depicts the contribution on the T-MPLS based Carrier Ethernet network with control plane based on NGN...... at illustrating the improvement of the Carrier Ethernet network with the NGN control plane....

Development of next-generation light water reactor

International Nuclear Information System (INIS)

Ishibashi, Fumihiko; Yasuoka, Makoto

2010-01-01

The Next-Generation Light Water Reactor Development Program, a national project in Japan, was inaugurated in April 2008. The primary objective of this program is to meet the need for the replacement of existing nuclear power plants in Japan after 2030. With the aim of setting a global standard design, the reactor to be developed offers greatly improved safety, reliability, and economic efficiency through several innovative technologies, including a reactor core system with uranium enrichment of 5 to 10%, a seismic isolation system, long-life materials, advanced water chemistry, innovative construction techniques, optimized passive and active safety systems, innovative digital technologies, and so on. In the first three years, a plant design concept with these innovative features is to be established and the effectiveness of the program will be reevaluated. The major part of the program will be completed in 2015. Toshiba is actively engaged in both design studies and technology development as a founding member of this program. (author)

MiSeq: A Next Generation Sequencing Platform for Genomic Analysis.

Science.gov (United States)

Ravi, Rupesh Kanchi; Walton, Kendra; Khosroheidari, Mahdieh

2018-01-01

MiSeq, Illumina's integrated next generation sequencing instrument, uses reversible-terminator sequencing-by-synthesis technology to provide end-to-end sequencing solutions. The MiSeq instrument is one of the smallest benchtop sequencers that can perform onboard cluster generation, amplification, genomic DNA sequencing, and data analysis, including base calling, alignment and variant calling, in a single run. It performs both single- and paired-end runs with adjustable read lengths from 1 × 36 base pairs to 2 × 300 base pairs. A single run can produce output data of up to 15 Gb in as little as 4 h of runtime and can output up to 25 M single reads and 50 M paired-end reads. Thus, MiSeq provides an ideal platform for rapid turnaround time. MiSeq is also a cost-effective tool for various analyses focused on targeted gene sequencing (amplicon sequencing and target enrichment), metagenomics, and gene expression studies. For these reasons, MiSeq has become one of the most widely used next generation sequencing platforms. Here, we provide a protocol to prepare libraries for sequencing using the MiSeq instrument and basic guidelines for analysis of output data from the MiSeq sequencing run.

Next-generation sequencing for endocrine cancers: Recent advances and challenges.

Science.gov (United States)

Suresh, Padmanaban S; Venkatesh, Thejaswini; Tsutsumi, Rie; Shetty, Abhishek

2017-05-01

Contemporary molecular biology research tools have enriched numerous areas of biomedical research that address challenging diseases, including endocrine cancers (pituitary, thyroid, parathyroid, adrenal, testicular, ovarian, and neuroendocrine cancers). These tools have placed several intriguing clues before the scientific community. Endocrine cancers pose a major challenge in health care and research despite considerable attempts by researchers to understand their etiology. Microarray analyses have provided gene signatures from many cells, tissues, and organs that can differentiate healthy states from diseased ones, and even show patterns that correlate with stages of a disease. Microarray data can also elucidate the responses of endocrine tumors to therapeutic treatments. The rapid progress in next-generation sequencing methods has overcome many of the initial challenges of these technologies, and their advantages over microarray techniques have enabled them to emerge as valuable aids for clinical research applications (prognosis, identification of drug targets, etc.). A comprehensive review describing the recent advances in next-generation sequencing methods and their application in the evaluation of endocrine and endocrine-related cancers is lacking. The main purpose of this review is to illustrate the concepts that collectively constitute our current view of the possibilities offered by next-generation sequencing technological platforms, challenges to relevant applications, and perspectives on the future of clinical genetic testing of patients with endocrine tumors. We focus on recent discoveries in the use of next-generation sequencing methods for clinical diagnosis of endocrine tumors in patients and conclude with a discussion on persisting challenges and future objectives.

Next Generation Life Support Project Status

Science.gov (United States)

Barta, Daniel J.; Chullen, Cinda; Vega, Leticia; Cox, Marlon R.; Aitchison, Lindsay T.; Lange, Kevin E.; Pensinger, Stuart J.; Meyer, Caitlin E.; Flynn, Michael; Jackson, W. Andrew;

Next generation PanDA pilot for ATLAS and other experiments

International Nuclear Information System (INIS)

Nilsson, P; De, K; Megino, F Barreiro; Llamas, R Medrano; Bejar, J Caballero; Hover, J; Maeno, T; Wenaus, T; Love, P; Walker, R

2014-01-01

The Production and Distributed Analysis system (PanDA) has been in use in the ATLAS Experiment since 2005. It uses a sophisticated pilot system to execute submitted jobs on the worker nodes. While originally designed for ATLAS, the PanDA Pilot has recently been refactored to facilitate use outside of ATLAS. Experiments are now handled as plug-ins such that a new PanDA Pilot user only has to implement a set of prototyped methods in the plug-in classes, and provide a script that configures and runs the experiment-specific payload. We will give an overview of the Next Generation PanDA Pilot system and will present major features and recent improvements including live user payload debugging, data access via the Federated XRootD system, stage-out to alternative storage elements, support for the new ATLAS DDM system (Rucio), and an improved integration with glExec, as well as a description of the experiment-specific plug-in classes. The performance of the pilot system in processing LHC data on the OSG, LCG and Nordugrid infrastructures used by ATLAS will also be presented. We will describe plans for future development on the time scale of the next few years.

technical guidelines for the design and construction of the next generation of nuclear power plants with pressurized water reactors

International Nuclear Information System (INIS)

2009-01-01

These technical guidelines present the opinion of the French 'Groupe Permanent charge des Reacteurs nucleaires' (GPR) concerning the safety philosophy and approach as well as the general safety requirements to be applied for the design and construction of the next generation of nuclear power plants of the PWR (pressurized water reactor) type, assuming the construction of the first units of this generation would start at the beginning of the 21. century. These technical guidelines are based on common work of the French Institut de Protection et de Surete Nucleaire (IPSN) and of the German Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS). Moreover, these technical guidelines were extensively discussed with members of the German Reaktor Sicherheitskommission (RSK) until the end of 1998 and further with German experts. The context of these technical guidelines must be clearly understood. Faced with the current situation of nuclear energy in the world, the various nuclear steam supply system designers are developing new products, all of them claiming their intention of obtaining a higher safety level, by various ways. GPR believes that, for the operation of a new series of nuclear power plants at the beginning of the next century, the adequate way is to derive the design of these plants in an 'evolutionary' way from the design of existing plants, taking into account the operating experience and the in-depth studies conducted for such plants. Nevertheless, introduction of innovative features must also be considered in the frame of the design of the new generation of plants, especially in preventing and mitigating severe accidents. GPR underlines here that a significant improvement of the safety of the next generation of nuclear power plants at the design stage is necessary, compared to existing plants. If the search for improvement is a permanent concern in the field of safety, the necessity of a significant step at the design stage clearly derives from better

Addressing Three Common Myths about the Next Generation Science Standards

Science.gov (United States)

Huff, Kenneth L.

2016-01-01

Although the "Next Generation Science Standards" (NGSS Lead States 2013) were released over two years ago, misconceptions about what they are--and are not--persist. The "NGSS" provide for consistent science education opportunities for all students--regardless of demographics--with a level of rigor expected in every location and…

Advanced optical components for next-generation photonic networks

Science.gov (United States)

Yoo, S. J. B.

2003-08-01

Future networks will require very high throughput, carrying dominantly data-centric traffic. The role of Photonic Networks employing all-optical systems will become increasingly important in providing scalable bandwidth, agile reconfigurability, and low-power consumptions in the future. In particular, the self-similar nature of data traffic indicates that packet switching and burst switching will be beneficial in the Next Generation Photonic Networks. While the natural conclusion is to pursue Photonic Packet Switching and Photonic Burst Switching systems, there are significant challenges in realizing such a system due to practical limitations in optical component technologies. Lack of a viable all-optical memory technology will continue to drive us towards exploring rapid reconfigurability in the wavelength domain. We will introduce and discuss the advanced optical component technologies behind the Photonic Packet Routing system designed and demonstrated at UC Davis. The system is capable of packet switching and burst switching, as well as circuit switching with 600 psec switching speed and scalability to 42 petabit/sec aggregated switching capacity. By utilizing a combination of rapidly tunable wavelength conversion and a uniform-loss cyclic frequency (ULCF) arrayed waveguide grating router (AWGR), the system is capable of rapidly switching the packets in wavelength, time, and space domains. The label swapping module inside the Photonic Packet Routing system containing a Mach-Zehnder wavelength converter and a narrow-band fiber Bragg-grating achieves all-optical label swapping with optical 2R (potentially 3R) regeneration while maintaining optical transparency for the data payload. By utilizing the advanced optical component technologies, the Photonic Packet Routing system successfully demonstrated error-free, cascaded, multi-hop photonic packet switching and routing with optical-label swapping. This paper will review the advanced optical component technologies

Next generation Zero-Code control system UI

CERN Multimedia

CERN. Geneva

2017-01-01

Developing ergonomic user interfaces for control systems is challenging, especially during machine upgrade and commissioning where several small changes may suddenly be required. Zero-code systems, such as *Inspector*, provide agile features for creating and maintaining control system interfaces. More so, these next generation Zero-code systems bring simplicity and uniformity and brake the boundaries between Users and Developers. In this talk we present *Inspector*, a CERN made Zero-code application development system, and we introduce the major differences and advantages of using Zero-code control systems to develop operational UI.

Aptaligner: automated software for aligning pseudorandom DNA X-aptamers from next-generation sequencing data.

Science.gov (United States)

Lu, Emily; Elizondo-Riojas, Miguel-Angel; Chang, Jeffrey T; Volk, David E

2014-06-10

Next-generation sequencing results from bead-based aptamer libraries have demonstrated that traditional DNA/RNA alignment software is insufficient. This is particularly true for X-aptamers containing specialty bases (W, X, Y, Z, ...) that are identified by special encoding. Thus, we sought an automated program that uses the inherent design scheme of bead-based X-aptamers to create a hypothetical reference library and Markov modeling techniques to provide improved alignments. Aptaligner provides this feature as well as length error and noise level cutoff features, is parallelized to run on multiple central processing units (cores), and sorts sequences from a single chip into projects and subprojects.

"ASTRO 101" Course Materials 2.0: Next Generation Lecture Tutorials and Beyond

Science.gov (United States)

Slater, Stephanie; Grazier, Kevin

2015-01-01

Early efforts to create course materials were often local in scale and were based on "gut instinct," and classroom experience and observation. While subsequent efforts were often based on those same instincts and observations of classrooms, they also incorporated the results of many years of education research. These "second generation" course materials, such as lecture tutorials, relied heavily on research indicating that instructors need to actively engage students in the learning process. While imperfect, these curricular innovations, have provided evidence that research-based materials can be constructed, can easily be disseminated to a broad audience, and can provide measureable improvement in student learning across many settings. In order to improve upon this prior work, next generation materials must build upon the strengths of these innovations while engineering in findings from education research, cognitive science, and instructor feedback. A next wave of materials, including a set of next generation lecture tutorials, have been constructed with attention to the body of research on student motivation, and cognitive load; and they are responsive to our body of knowledge on learning difficulties related to specific content in the domain. From instructor feedback, these materials have been constructed to have broader coverage of the materials typically taught in an ASTRO 101 course, to take less class time, and to be more affordable for students. This next generation of lecture tutorials may serve as a template of the ways in which course materials can be reengineered to respond to current instructor and student needs.

Next generation vaccines.

Science.gov (United States)

Riedmann, Eva M

2011-07-01

In February this year, about 100 delegates gathered for three days in Vienna (Austria) for the Next Generation Vaccines conference. The meeting held in the Vienna Hilton Hotel from 23rd-25th February 2011 had a strong focus on biotech and industry. The conference organizer Jacob Fleming managed to put together a versatile program ranging from the future generation of vaccines to manufacturing, vaccine distribution and delivery, to regulatory and public health issues. Carefully selected top industry experts presented first-hand experience and shared solutions for overcoming the latest challenges in the field of vaccinology. The program also included several case study presentations on novel vaccine candidates in different stages of development. An interactive pre-conference workshop as well as interactive panel discussions during the meeting allowed all delegates to gain new knowledge and become involved in lively discussions on timely, interesting and sometimes controversial topics related to vaccines.

Application of next generation sequencing in clinical microbiology and infection prevention

NARCIS (Netherlands)

Deurenberg, Ruud H.; Bathoorn, Erik; Chlebowicz, Monika A.; Couto, Natacha; Ferdous, Mithila; Garcia-Cobos, Silvia; Kooistra-Smid, Anna M. D.; Raangs, Erwin C.; Rosema, Sigrid; Veloo, Alida C. M.; Zhou, Kai; Friedrich, Alexander W.; Rossen, John W. A.

2017-01-01

Current molecular diagnostics of human pathogens provide limited information that is often not sufficient for outbreak and transmission investigation. Next generation sequencing (NGS) determines the DNA sequence of a complete bacterial genome in a single sequence run, and from these data,

NOAA NEXt-Generation RADar (NEXRAD) Products

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level III weather radar products collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska,...

Four Corners project experience - Applications to next generation FGD

International Nuclear Information System (INIS)

Wild, R.L.; Grimes, R.L.; Wiggins, D.S.

1990-01-01

In June 1984, Arizona Public Service Company started up the flue gas desulfurization system installed on Units 4 and 5 at the Four Corners Power Station. At the time, this represented the largest emissions control retrofit in the industry, and consisted of two 800 MWe units. These units burn a low sulfur subbituminous coal from the adjacent Navajo mine. The FGD system was designed for 72% overall removal, with partial bypass. The SO 2 absorbers were designed for 90% removal. This FGD system is considered to be a second generation design. At the time, it represented state-of-the-art of FGD technology, in terms of both process considerations and materials of construction. In the six years since startup, several modifications have been made in the areas of process chemistry, equipment configuration, and materials of construction. These modifications are applicable to the next generation of FGD systems which will be designed in response to Acid Rain Legislation. This paper presents the original plant design basis, summarizes the operating experience to date, and identifies the modifications and improvements which have been made since startup. In addition, recommendations for new installations are offered

The Next Generation Science Standards

Science.gov (United States)

Pruitt, Stephen L.

2015-01-01

The Next Generation Science Standards (NGSS Lead States 2013) were released almost two years ago. Work tied to the NGSS, their adoption, and implementation continues to move forward around the country. Stephen L. Pruitt, senior vice president, science, at Achieve, an independent, nonpartisan, nonprofit education reform organization that was a lead…

Research and Development Supporting a Next Generation Germanium Double Beta Decay Experiment

Science.gov (United States)

Rielage, Keith; Elliott, Steve; Chu, Pinghan; Goett, Johnny; Massarczyk, Ralph; Xu, Wenqin

2015-10-01

To improve the search for neutrinoless double beta decay, the next-generation experiments will increase in source mass and continue to reduce backgrounds in the region of interest. A promising technology for the next generation experiment is large arrays of Germanium p-type point contact detectors enriched in 76-Ge. The experience, expertise and lessons learned from the MAJORANA DEMONSTRATOR and GERDA experiments naturally lead to a number of research and development activities that will be useful in guiding a future experiment utilizing Germanium. We will discuss some R&D activities including a hybrid cryostat design, background reduction in cabling, connectors and electronics, and modifications to reduce assembly time. We acknowledge the support of the U.S. Department of Energy through the LANL/LDRD Program.

Cold-Crucible Design Parameters for Next Generation HLW Melters

International Nuclear Information System (INIS)

Gombert, D.; Richardson, J.; Aloy, A.; Day, D.

2002-01-01

The cold-crucible induction melter (CCIM) design eliminates many materials and operating constraints inherent in joule-heated melter (JHM) technology, which is the standard for vitrification of high-activity wastes worldwide. The cold-crucible design is smaller, less expensive, and generates much less waste for ultimate disposal. It should also allow a much more flexible operating envelope, which will be crucial if the heterogeneous wastes at the DOE reprocessing sites are to be vitrified. A joule-heated melter operates by passing current between water-cooled electrodes through a molten pool in a refractory-lined chamber. This design is inherently limited by susceptibility of materials to corrosion and melting. In addition, redox conditions and free metal content have exacerbated materials problems or lead to electrical short-circuiting causing failures in DOE melters. In contrast, the CCIM design is based on inductive coupling of a water-cooled high-frequency electrical coil with the glass, causing eddycurrents that produce heat and mixing. A critical difference is that inductance coupling transfers energy through a nonconductive solid layer of slag coating the metal container inside the coil, whereas the jouleheated design relies on passing current through conductive molten glass in direct contact with the metal electrodes and ceramic refractories. The frozen slag in the CCIM design protects the containment and eliminates the need for refractory, while the corrosive molten glass can be the limiting factor in the JH melter design. The CCIM design also eliminates the need for electrodes that typically limit operating temperature to below 1200 degrees C. While significant marketing claims have been made by French and Russian technology suppliers and developers, little data is available for engineering and economic evaluation of the technology, and no facilities are available in the US to support testing. A currently funded project at the Idaho National Engineering

The Next Generation of Science Standards: Implications for Biology Education

Science.gov (United States)

Bybee, Rodger W.

2012-01-01

The release of A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas (NRC, 2012) provides the basis for the next generation of science standards. This article first describes that foundation for the life sciences; it then presents a draft standard for natural selection and evolution. Finally, there is a…

IPv6: The Next Generation Internet Protocol

Indian Academy of Sciences (India)

addressing, new generation internet. 2. ... required the creation of the next generation of Internet ... IPv6 standards have defined the following Extension headers ..... addresses are represented as x:x:x:x:x:x:x:x, where each x is the hexadecimal ...

Performance analysis of next-generation lunar laser retroreflectors

Science.gov (United States)

Ciocci, Emanuele; Martini, Manuele; Contessa, Stefania; Porcelli, Luca; Mastrofini, Marco; Currie, Douglas; Delle Monache, Giovanni; Dell'Agnello, Simone

2017-09-01

Starting from 1969, Lunar Laser Ranging (LLR) to the Apollo and Lunokhod Cube Corner Retroreflectors (CCRs) provided several tests of General Relativity (GR). When deployed, the Apollo/Lunokhod CCRs design contributed only a negligible fraction of the ranging error budget. Today the improvement over the years in the laser ground stations makes the lunar libration contribution relevant. So the libration now dominates the error budget limiting the precision of the experimental tests of gravitational theories. The MoonLIGHT-2 project (Moon Laser Instrumentation for General relativity High-accuracy Tests - Phase 2) is a next-generation LLR payload developed by the Satellite/lunar/GNSS laser ranging/altimetry and Cube/microsat Characterization Facilities Laboratory (SCF _ Lab) at the INFN-LNF in collaboration with the University of Maryland. With its unique design consisting of a single large CCR unaffected by librations, MoonLIGHT-2 can significantly reduce error contribution of the reflectors to the measurement of the lunar geodetic precession and other GR tests compared to Apollo/Lunokhod CCRs. This paper treats only this specific next-generation lunar laser retroreflector (MoonLIGHT-2) and it is by no means intended to address other contributions to the global LLR error budget. MoonLIGHT-2 is approved to be launched with the Moon Express 1(MEX-1) mission and will be deployed on the Moon surface in 2018. To validate/optimize MoonLIGHT-2, the SCF _ Lab is carrying out a unique experimental test called SCF-Test: the concurrent measurement of the optical Far Field Diffraction Pattern (FFDP) and the temperature distribution of the CCR under thermal conditions produced with a close-match solar simulator and simulated space environment. The focus of this paper is to describe the SCF _ Lab specialized characterization of the performance of our next-generation LLR payload. While this payload will improve the contribution of the error budget of the space segment (MoonLIGHT-2

Tablet—next generation sequence assembly visualization

Science.gov (United States)

Milne, Iain; Bayer, Micha; Cardle, Linda; Shaw, Paul; Stephen, Gordon; Wright, Frank; Marshall, David

2010-01-01

Summary: Tablet is a lightweight, high-performance graphical viewer for next-generation sequence assemblies and alignments. Supporting a range of input assembly formats, Tablet provides high-quality visualizations showing data in packed or stacked views, allowing instant access and navigation to any region of interest, and whole contig overviews and data summaries. Tablet is both multi-core aware and memory efficient, allowing it to handle assemblies containing millions of reads, even on a 32-bit desktop machine. Availability: Tablet is freely available for Microsoft Windows, Apple Mac OS X, Linux and Solaris. Fully bundled installers can be downloaded from http://bioinf.scri.ac.uk/tablet in 32- and 64-bit versions. Contact: tablet@scri.ac.uk PMID:19965881

Next Generation Nuclear Plant Project Technology Development Roadmaps: The Technical Path Forward

Energy Technology Data Exchange (ETDEWEB)

John Collins

2009-01-01

This document presents the Next Generation Nuclear Plant (NGNP) Systems, Subsystems, and Components, establishes a baseline for the current technology readiness status, and provides a path forward to achieve increasing levels of technical maturity.

Next-generation wireless technologies 4G and beyond

CERN Document Server

Chilamkurti, Naveen; Chaouchi, Hakima

2013-01-01

This comprehensive text/reference examines the various challenges to secure, efficient and cost-effective next-generation wireless networking. Topics and features: presents the latest advances, standards and technical challenges in a broad range of emerging wireless technologies; discusses cooperative and mesh networks, delay tolerant networks, and other next-generation networks such as LTE; examines real-world applications of vehicular communications, broadband wireless technologies, RFID technology, and energy-efficient wireless communications; introduces developments towards the 'Internet o

Multiple Access Techniques for Next Generation Wireless: Recent Advances and Future Perspectives

Directory of Open Access Journals (Sweden)

Shree Krishna Sharma

2016-01-01

Full Text Available The advances in multiple access techniques has been one of the key drivers in moving from one cellular generation to another. Starting from the first generation, several multiple access techniques have been explored in different generations and various emerging multiplexing/multiple access techniques are being investigated for the next generation of cellular networks. In this context, this paper first provides a detailed review on the existing Space Division Multiple Access (SDMA related works. Subsequently, it highlights the main features and the drawbacks of various existing and emerging multiplexing/multiple access techniques. Finally, we propose a novel concept of clustered orthogonal signature division multiple access for the next generation of cellular networks. The proposed concept envisions to employ joint antenna coding in order to enhance the orthogonality of SDMA beams with the objective of enhancing the spectral efficiency of future cellular networks.

Self-shielding characteristics of aqueous self-cooled blankets for next generation fusion devices

International Nuclear Information System (INIS)

Pelloni, S.; Cheng, E.T.; Embrechts, M.J.

1987-11-01

The present study examines self-shielding characteristics for two aqueous self-cooled tritium producing driver blankets for next generation fusion devices. The aqueous Self-Cooled Blanket concept (ASCB) is a very simple blanket concept that relies on just structural material and coolant. Lithium compounds are dissolved in water to provide for tritium production. An ASCB driver blanket would provide a low technology and low temperature environment for blanket test modules in a next generation fusion reactor. The primary functions of such a blanket would be shielding, energy removal and tritium production. One driver blanket considered in this study concept relates to the one proposed for the Next European Torus (NET), while the second concept is indicative for the inboard shield design for the Engineering Test Reactor proposed by the USA (TIBER II/ETR). The driver blanket for NET is based on stainless steel for the structural material and aqueous solution, while the inboard shielding blanket for TIBER II/ETR is based on a tungsten/aqueous solution combination. The purpose of this study is to investigate self-shielding and heterogeneity effects in aqueous self-cooled blankets. It is found that no significant gains in tritium breeding can be achieved in the stainless steel blanket if spatial and energy self-shielding effects are considered, and the heterogeneity effects are also insignificant. The tungsten blanket shows a 5 percent increase in tritium production in the shielding blanket when energy and spatial self-shielding effects are accounted for. However, the tungsten blanket shows a drastic increase in the tritium breeding ratio due to heterogeneity effects. (author) 17 refs., 9 figs., 9 tabs

Next-generation mid-infrared sources

Science.gov (United States)

Jung, D.; Bank, S.; Lee, M. L.; Wasserman, D.

2017-12-01

to provide a survey of the current state of the art for mid-IR sources, but instead looks primarily to provide a picture of potential next-generation optical and optoelectronic materials systems for mid-IR light generation.

Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data

Directory of Open Access Journals (Sweden)

Niko eBeerenwinkel

2012-09-01

Full Text Available Many viruses, including the clinically relevant RNA viruses HIV and HCV, exist in large populations and display high genetic heterogeneity within and between infected hosts. Assessing intra-patient viral genetic diversity is essential for understanding the evolutionary dynamics of viruses, for designing effective vaccines, and for the success of antiviral therapy. Next-generation sequencing technologies allow the rapid and cost-effective acquisition of thousands to millions of short DNA sequences from a single sample. However, this approach entails several challenges in experimental design and computational data analysis. Here, we review the entire process of inferring viral diversity from sample collection to computing measures of genetic diversity. We discuss sample preparation, including reverse transcription and amplification, and the effect of experimental conditions on diversity estimates due to in vitro base substitutions, insertions, deletions, and recombination. The use of different next-generation sequencing platforms and their sequencing error profiles are compared in the context of various applications of diversity estimation, ranging from the detection of single nucleotide variants to the reconstruction of whole-genome haplotypes. We describe the statistical and computational challenges arising from these technical artifacts, and we review existing approaches, including available software, for their solution. Finally, we discuss open problems, and highlight successful biomedical applications and potential future clinical use of next-generation sequencing to estimate viral diversity.

Next-generation genome-scale models for metabolic engineering

DEFF Research Database (Denmark)

King, Zachary A.; Lloyd, Colton J.; Feist, Adam M.

2015-01-01

Constraint-based reconstruction and analysis (COBRA) methods have become widely used tools for metabolic engineering in both academic and industrial laboratories. By employing a genome-scale in silico representation of the metabolic network of a host organism, COBRA methods can be used to predict...... examples of applying COBRA methods to strain optimization are presented and discussed. Then, an outlook is provided on the next generation of COBRA models and the new types of predictions they will enable for systems metabolic engineering....

Next Generation of Photovoltaics New Concepts

CERN Document Server

Vega, Antonio; López, Antonio

2012-01-01

This book presents new concepts for a next generation of PV. Among these concepts are: Multijunction solar cells, multiple excitation solar cells (or how to take benefit of high energy photons for the creation of more than one electron hole-pair), intermediate band solar cells (or how to take advantage of below band-gap energy photons) and related technologies (for quantum dots, nitrides, thin films), advanced light management approaches (plasmonics). Written by world-class experts in next generation photovoltaics this book is an essential reference guide accessible to both beginners and experts working with solar cell technology. The book deeply analyzes the current state-of-the-art of the new photovoltaic approaches and outlines the implementation paths of these advanced devices. Topics addressed range from the fundamentals to the description of state-of-the-art of the new types of solar cells.

Next generation biofuel engineering in prokaryotes

Science.gov (United States)

Gronenberg, Luisa S.; Marcheschi, Ryan J.; Liao, James C.

2014-01-01

Next-generation biofuels must be compatible with current transportation infrastructure and be derived from environmentally sustainable resources that do not compete with food crops. Many bacterial species have unique properties advantageous to the production of such next-generation fuels. However, no single species possesses all characteristics necessary to make high quantities of fuels from plant waste or CO2. Species containing a subset of the desired characteristics are used as starting points for engineering organisms with all desired attributes. Metabolic engineering of model organisms has yielded high titer production of advanced fuels, including alcohols, isoprenoids and fatty acid derivatives. Technical developments now allow engineering of native fuel producers, as well as lignocellulolytic and autotrophic bacteria, for the production of biofuels. Continued research on multiple fronts is required to engineer organisms for truly sustainable and economical biofuel production. PMID:23623045

Next generation of photovoltaics. New concepts

Energy Technology Data Exchange (ETDEWEB)

Cristobal Lopez, Ana Belen; Marti Vega, Antonio; Luque Lopez, Antonio (eds.) [Univ. Politecnica de Madrid (Spain). Inst. de Energia Solar E.T.S.I. Telecomunicacion

2012-07-01

This book presents new concepts for a next generation of PV. Among these concepts are: Multijunction solar cells, multiple excitation solar cells (or how to take benefit of high energy photons for the creation of more than one electron hole-pair), intermediate band solar cells (or how to take advantage of below band-gap energy photons) and related technologies (for quantum dots, nitrides, thin films), advanced light management approaches (plasmonics). Written by world-class experts in next generation photovoltaics this book is an essential reference guide accessible to both beginners and experts working with solar cell technology. The book deeply analyzes the current state-of-the-art of the new photovoltaic approaches and outlines the implementation paths of these advanced devices. Topics addressed range from the fundamentals to the description of state-of-the-art of the new types of solar cells. (orig.)

The Next Generation Nuclear Plant/Advanced Gas Reactor Fuel Irradiation Experiments in the Advanced Test Reactor

International Nuclear Information System (INIS)

Grover, S. Blaine

2009-01-01

The United States Department of Energy's Next Generation Nuclear Plant (NGNP) Program will be irradiating eight separate low enriched uranium (LEU) tri-isotopic (TRISO) particle fuel (in compact form) experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). The ATR has a long history of irradiation testing in support of reactor development and the INL has been designated as the new United States Department of Energy's lead laboratory for nuclear energy development. The ATR is one of the world's premiere test reactors for performing long term, high flux, and/or large volume irradiation test programs. These irradiations and fuel development are being accomplished to support development of the next generation reactors in the United States, and will be irradiated over the next ten years to demonstrate and qualify new particle fuel for use in high temperature gas reactors. The goals of the irradiation experiments are to provide irradiation performance data to support fuel process development, to qualify fuel for normal operating conditions, to support development and validation of fuel performance and fission product transport models and codes, and to provide irradiated fuel and materials for post irradiation examination (PIE) and safety testing. The experiments, which will each consist of at least six separate capsules, will be irradiated in an inert sweep gas atmosphere with individual on-line temperature monitoring and control of each capsule. The sweep gas will also have on-line fission product monitoring on its effluent to track performance of the fuel in each individual capsule during irradiation. The first experiment (designated AGR-1) started irradiation in December 2006, and the second experiment (AGR-2) is currently in the design phase. The design of test trains, as well as the support systems and fission product monitoring system that will monitor and control the experiment during irradiation will be discussed. In

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

Directory of Open Access Journals (Sweden)

Patrice D. Cani

2017-09-01

Full Text Available Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide epidemic. Among the different environmental factors, the gut microbiota is now considered as a key player interfering with energy metabolism and host susceptibility to several non-communicable diseases. Among the next-generation beneficial microbes that have been identified, Akkermansia muciniphila is a promising candidate. Indeed, A. muciniphila is inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation. Besides the numerous correlations observed, a large body of evidence has demonstrated the causal beneficial impact of this bacterium in a variety of preclinical models. Translating these exciting observations to human would be the next logic step and it now appears that several obstacles that would prevent the use of A. muciniphila administration in humans have been overcome. Moreover, several lines of evidence indicate that pasteurization of A. muciniphila not only increases its stability but more importantly increases its efficacy. This strongly positions A. muciniphila in the forefront of next-generation candidates for developing novel food or pharma supplements with beneficial effects. Finally, a specific protein present on the outer membrane of A. muciniphila, termed Amuc_1100, could be strong candidate for future drug development. In conclusion, as plants and its related knowledge, known as pharmacognosy, have been the source for designing drugs over the last century, we propose that microbes and microbiomegnosy, or knowledge of our gut microbiome, can become a novel source of future therapies.

Next Generation Antibody Therapeutics Using Bispecific Antibody Technology.

Science.gov (United States)

Igawa, Tomoyuki

2017-01-01

Nearly fifty monoclonal antibodies have been approved to date, and the market for monoclonal antibodies is expected to continue to grow. Since global competition in the field of antibody therapeutics is intense, we need to establish novel antibody engineering technologies to provide true benefit for patients, with differentiated product values. Bispecific antibodies are among the next generation of antibody therapeutics that can bind to two different target antigens by the two arms of immunoglobulin G (IgG) molecule, and are thus believed to be applicable to various therapeutic needs. Until recently, large scale manufacturing of human IgG bispecific antibody was impossible. We have established a technology, named asymmetric re-engineering technology (ART)-Ig, to enable large scale manufacturing of bispecific antibodies. Three examples of next generation antibody therapeutics using ART-Ig technology are described. Recent updates on bispecific antibodies against factor IXa and factor X for the treatment of hemophilia A, bispecific antibodies against a tumor specific antigen and T cell surface marker CD3 for cancer immunotherapy, and bispecific antibodies against two different epitopes of soluble antigen with pH-dependent binding property for the elimination of soluble antigen from plasma are also described.

Use of virtual environments to reduce the construction costs of the next generation nuclear power reactors

International Nuclear Information System (INIS)

Whisker, V.E.; Baratta, A.J.

2007-01-01

The near term deployment of the next generation of reactors will only be successful if they are built on time and without the costly overruns experienced in the previous generation. One critical factor in achieving these goals is to ensure the design is optimized for constructability. In this work the authors explored the effectiveness of full-scale virtual reality simulation in the optimization of the design and construction of the next generation of nuclear reactors. The research tested the suitability of immersive virtual reality display technology in aiding engineers in evaluating potential cost reductions that can be realized by the optimization of design and installation and construction sequences. The intent of this research is to see if this type of technology can be used in capacities similar to those currently filled by full-scale physical mockups and desktop simulations. Using a fully-immersive five sided virtual reality system, known as a CAVE, the authors constructed a series of virtual mockups that represented two next generation nuclear power plants, the Westinghouse AP-1000 and the Pebble Bed Modular Reactor (PBMR). These virtual mockups were then tested as a design tool to help locate and correct problem areas, to optimize the construction sequence, and to assist with familiarizing trades people with the performance of maintenance activities. A series of experiments were performed to assess the usefulness of these virtual mockups in accomplishing these tasks. (authors)

An assessment the severe accident equipment survivability for the Korean Next Generation Reactor

International Nuclear Information System (INIS)

Lee, B. C.; Moon, Y. T.; Park, J. W.; Kho, H. J.; Lee, S. W.

1999-01-01

One of the prominent design approaches to cope with the severe accident challenges in the Korean Next Generation Reactor is an assessment of equipment survivability in the severe accident environment at early design stage. In compliance with 10CFR50.34(f) and SECY-93-087, this work addresses that a reasonable level of assurance be provided to demonstrate that sufficient instrumentation and equipment will survive the consequences of a severe accident and will be available so that the operator may recover from and trend severe core damage sequences, including those scenarios which result in 100 percent oxidation of the active fuel cladding. An analytical and systematic approach was used to identify the equipment and instrumentation of safety-function and define severe accident environments including temperature, pressure, humidity, and radiation before and after the reactor vessel breach. As a result, it was concluded that with minor exceptions, existing design basis equipment qualification methods are sufficient to provide a reasonable level of assurance that this equipment will function during a severe accident. Furthermore, supplemental severe accident equipment and instrument procurement requirements were identified. (author)

MP CBM-Z V1.0: design for a new CBM-Z gas-phase chemical mechanism architecture for next generation processors

OpenAIRE

Wang, Hui; Lin, Junmin; Wu, Qizhong; Chen, Huansheng; Tang, Xiao; Wang, Zifa; Chen, Xueshun; Cheng, Huaqiong; Wang, Lanning

2018-01-01

Precise and rapid air quality simulation and forecasting are limited by the computation performance of the air quality model, and the gas-phase chemistry module is the most time-consuming function in the air quality model. In this study, we designed a new framework for the widely used Carbon Bond Mechanism Z (CBM-Z) gas-phase chemical kinetics kernel to adapt the Single Instruction Multiple Data (SIMD) technology in the next-generation processors for improving its calculation performance. The...

A National Demonstration Project Building the Next Generation

International Nuclear Information System (INIS)

Keuter, Dan; Hughey, Kenneth; Melancon, Steve; Quinn, Edward 'Ted'

2002-01-01

energy situation, and in a way which supports U.S. environmental objectives. A key element of this effort will be the reestablishment and maintenance of an industrial base, which can be accessed in response to changing national energy needs. Right now, in a cooperative program through the U.S. Department of Energy, U.S. and Russian dollars are paying for over 700 Russian nuclear scientists and engineers to complete design work on the Gas Turbine - Modular Helium Reactor (GT-MHR), a next generation nuclear power plant that is melt-down proof, substantially more efficient that the existing generation of reactors, creates substantially less waste and is extremely proliferation resistant. To date, the Russians are providing world class engineering design work, resulting in the program being on track to begin construction of this first of a kind reactor by the end of 2005. Just as important in parallel with this effort, a number of key U.S. utilities are speaking with Congress and the Administration to 'piggy back' off this U.S./Russian effort to promote a joint private-public partnership to construct in parallel a similar first of a kind reactor in the U.S. (authors)

NGSUtils: a software suite for analyzing and manipulating next-generation sequencing datasets

OpenAIRE

Breese, Marcus R.; Liu, Yunlong

2013-01-01

Summary: NGSUtils is a suite of software tools for manipulating data common to next-generation sequencing experiments, such as FASTQ, BED and BAM format files. These tools provide a stable and modular platform for data management and analysis.

Next-generation Digital Earth.

Science.gov (United States)

Goodchild, Michael F; Guo, Huadong; Annoni, Alessandro; Bian, Ling; de Bie, Kees; Campbell, Frederick; Craglia, Max; Ehlers, Manfred; van Genderen, John; Jackson, Davina; Lewis, Anthony J; Pesaresi, Martino; Remetey-Fülöpp, Gábor; Simpson, Richard; Skidmore, Andrew; Wang, Changlin; Woodgate, Peter

2012-07-10

A speech of then-Vice President Al Gore in 1998 created a vision for a Digital Earth, and played a role in stimulating the development of a first generation of virtual globes, typified by Google Earth, that achieved many but not all the elements of this vision. The technical achievements of Google Earth, and the functionality of this first generation of virtual globes, are reviewed against the Gore vision. Meanwhile, developments in technology continue, the era of "big data" has arrived, the general public is more and more engaged with technology through citizen science and crowd-sourcing, and advances have been made in our scientific understanding of the Earth system. However, although Google Earth stimulated progress in communicating the results of science, there continue to be substantial barriers in the public's access to science. All these factors prompt a reexamination of the initial vision of Digital Earth, and a discussion of the major elements that should be part of a next generation.

Next-Generation Satellite Precipitation Products for Understanding Global and Regional Water Variability

Science.gov (United States)

Hou, Arthur Y.

2011-01-01

A major challenge in understanding the space-time variability of continental water fluxes is the lack of accurate precipitation estimates over complex terrains. While satellite precipitation observations can be used to complement ground-based data to obtain improved estimates, space-based and ground-based estimates come with their own sets of uncertainties, which must be understood and characterized. Quantitative estimation of uncertainties in these products also provides a necessary foundation for merging satellite and ground-based precipitation measurements within a rigorous statistical framework. Global Precipitation Measurement (GPM) is an international satellite mission that will provide next-generation global precipitation data products for research and applications. It consists of a constellation of microwave sensors provided by NASA, JAXA, CNES, ISRO, EUMETSAT, DOD, NOAA, NPP, and JPSS. At the heart of the mission is the GPM Core Observatory provided by NASA and JAXA to be launched in 2013. The GPM Core, which will carry the first space-borne dual-frequency radar and a state-of-the-art multi-frequency radiometer, is designed to set new reference standards for precipitation measurements from space, which can then be used to unify and refine precipitation retrievals from all constellation sensors. The next-generation constellation-based satellite precipitation estimates will be characterized by intercalibrated radiometric measurements and physical-based retrievals using a common observation-derived hydrometeor database. For pre-launch algorithm development and post-launch product evaluation, NASA supports an extensive ground validation (GV) program in cooperation with domestic and international partners to improve (1) physics of remote-sensing algorithms through a series of focused field campaigns, (2) characterization of uncertainties in satellite and ground-based precipitation products over selected GV testbeds, and (3) modeling of atmospheric processes and

Next generation HOM-damping

Science.gov (United States)

Marhauser, Frank

2017-06-01

Research and development for superconducting radio-frequency cavities has made enormous progress over the last decades from the understanding of theoretical limitations to the industrial mass fabrication of cavities for large-scale particle accelerators. Key technologies remain hot topics due to continuously growing demands on cavity performance, particularly when in pursuit of high quality beams at higher beam currents or higher luminosities than currently achievable. This relates to higher order mode (HOM) damping requirements. Meeting the desired beam properties implies avoiding coupled multi-bunch or beam break-up instabilities depending on the machine and beam parameters that will set the acceptable cavity impedance thresholds. The use of cavity HOM-dampers is crucial to absorb the wakefields, comprised by all beam-induced cavity Eigenmodes, to beam-dynamically safe levels and to reduce the heat load at cryogenic temperature. Cavity damping concepts may vary, but are principally based on coaxial and waveguide couplers as well as beam line absorbers or any combination. Next generation energy recovery linacs and circular colliders call for cavities with strong HOM-damping that can exceed the state-of-the-art, while the operating mode efficiency shall not be significantly compromised concurrently. This imposes major challenges given the rather limited damping concepts. A detailed survey of established cavities is provided scrutinizing the achieved damping performance, shortcomings, and potential improvements. The scaling of the highest passband mode impedances is numerically evaluated in dependence on the number of cells for a single-cell up to a nine-cell cavity, which reveals the increased probability of trapped modes. This is followed by simulations for single-cell and five-cell cavities, which incorporate multiple damping schemes to assess the most efficient concepts. The usage and viability of on-cell dampers is elucidated for the single-cell cavity since it

Next Generation Science Standards: Considerations for Curricula, Assessments, Preparation, and Implementation

Science.gov (United States)

Best, Jane; Dunlap, Allison

2014-01-01

This policy brief provides an overview of the Next Generation Science Standards (NGSS), discusses policy considerations for adopting or adapting the new standards, and presents examples from states considering or implementing the NGSS. Changing academic standards is a complex process that requires significant investments of time, money, and human…

A Survey on 5G: The Next Generation of Mobile Communication

OpenAIRE

Panwar, Nisha; Sharma, Shantanu; Singh, Awadhesh Kumar

2015-01-01

The rapidly increasing number of mobile devices, voluminous data, and higher data rate are pushing to rethink the current generation of the cellular mobile communication. The next or fifth generation (5G) cellular networks are expected to meet high-end requirements. The 5G networks are broadly characterized by three unique features: ubiquitous connectivity, extremely low latency, and very high-speed data transfer. The 5G networks would provide novel architectures and technologies beyond state...

Special Issue: Next Generation DNA Sequencing

Directory of Open Access Journals (Sweden)

Paul Richardson

2010-10-01

Full Text Available Next Generation Sequencing (NGS refers to technologies that do not rely on traditional dideoxy-nucleotide (Sanger sequencing where labeled DNA fragments are physically resolved by electrophoresis. These new technologies rely on different strategies, but essentially all of them make use of real-time data collection of a base level incorporation event across a massive number of reactions (on the order of millions versus 96 for capillary electrophoresis for instance. The major commercial NGS platforms available to researchers are the 454 Genome Sequencer (Roche, Illumina (formerly Solexa Genome analyzer, the SOLiD system (Applied Biosystems/Life Technologies and the Heliscope (Helicos Corporation. The techniques and different strategies utilized by these platforms are reviewed in a number of the papers in this special issue. These technologies are enabling new applications that take advantage of the massive data produced by this next generation of sequencing instruments. [...

Next Generation Electromagnetic Pump Analysis Tools (PLM DOC-0005-2188). Final Report

Energy Technology Data Exchange (ETDEWEB)

Stregy, Seth [GE Hitachi Nuclear Energy Americas LLC, Wilmington, NC (United States); Dasilva, Ana [GE Hitachi Nuclear Energy Americas LLC, Wilmington, NC (United States); Yilmaz, Serkan [GE Hitachi Nuclear Energy Americas LLC, Wilmington, NC (United States); Saha, Pradip [GE Hitachi Nuclear Energy Americas LLC, Wilmington, NC (United States); Loewen, Eric [GE Hitachi Nuclear Energy Americas LLC, Wilmington, NC (United States)

2015-10-29

This report provides the broad historical review of EM Pump development and details of MATRIX development under this project. This report summarizes the efforts made to modernize the legacy performance models used in previous EM Pump designs and the improvements made to the analysis tools. This report provides information on Tasks 1, 3, and 4 of the entire project. The research for Task 4 builds upon Task 1: Update EM Pump Databank and Task 3: Modernize the Existing EM Pump Analysis Model, which are summarized within this report. Where research for Task 2: Insulation Materials Development and Evaluation identified parameters applicable to the analysis model with Task 4, the analysis code was updated, and analyses were made for additional materials. The important design variables for the manufacture and operation of an EM Pump that the model improvement can evaluate are: space constraints; voltage capability of insulation system; maximum flux density through iron; flow rate and outlet pressure; efficiency and manufacturability. The development of the next-generation EM Pump analysis tools during this two-year program provides information in three broad areas: Status of analysis model development; Improvements made to older simulations; and Comparison to experimental data.

EDF view on next generation reactor safety and operability issues

International Nuclear Information System (INIS)

Serviere, G.

2002-01-01

In the foreseeable future, EDF will have to compete in an economically de-regulated market. Nuclear currently accounts for more than 80% of the electricity generated by the company, and generation costs are quite competitive compared to that of other competing energies. It is so likely that nuclear units will remain the backbone of EDF generating fleet in the years to come. However, to remain a viable option for electricity generation in the longer term, nuclear will have to maintain both its cost-effectiveness and a very high safety level. This could seem quite straightforward considering the current situation where safety records are at an all time high and Operating and Maintenance costs are under tight control. In fact, it could be a real challenge. Competing fossil technologies progress and there is a concurrent trend to try and improve the performance of future nuclear units. However, in most cases, proposed designs depart from the well-known Light Water Reactor (LWR) technology. They are either new concepts or designs already tested in the past and modified to address some of their perceived drawbacks. Contrary to the prevailing situation where short-term alternatives like the EPR, the ABWR or the AP600 largely build upon experience gathered on operating units, most designs contemplated for implementation beyond 2020 or 2030 cannot be considered proven. Considering the above mentioned uncertainties, EDF have confirmed their preference for proven designs with higher outputs, such as the EPR. However, it would appear unreasonable to consider that new designs are doomed to fail: they could well turn out to be adequate for specific niches in a de-regulated market and provide reasonable alternatives for the utility. Nevertheless, for such an alternative to be considered, additional evidence is needed that utility preferences are reflected in the design, and that all potential technical issues have been identified, adequately addressed and resolved. Currently, EDF

Next-Generation Photon Sources for Grand Challenges in Science and Energy

Energy Technology Data Exchange (ETDEWEB)

None

2009-05-01

to avoid radiation damage in high-resolution spatial imaging and to avoid space-charge broadening in photoelectron spectroscopy and microscopy. But light sources alone are not enough. The photons produced by next-generation light sources must be measured by state-of-the-art experiments installed at fully equipped end stations. Sophisticated detectors with unprecedented spatial, temporal, and spectral resolution must be designed and created. The theory of ultrafast phenomena that have never before been observed must be developed and implemented. Enormous data sets of diffracted signals in reciprocal space and across wide energy ranges must be collected and analyzed in real time so that they can guide the ongoing experiments. These experimental challenges - end stations, detectors, sophisticated experiments, theory, and data handling - must be planned and provided for as part of the photon source.

GEANT4: simulation for the next generation of HEP experiments

International Nuclear Information System (INIS)

Simone, Giani

1996-01-01

GEANT4 (RD44) is a world-wide collaboration of scientists aiming to create the detector simulation tool kit necessary for the next generation of HEP experiments. A large variety of requirements also come from heavy ions physics, CP violation physics, cosmic rays physics, medical applications and space science applications. In order to meet such requirements, a large degree of functionality and flexibility has to provided. GEANT4 is exploiting Object Oriented Technology to achieve these goals. The most relevant Object Oriented methodologies have been studied and a large number of tools and libraries have been investigated and evaluated. An overview of the GEANT4 analysis and design model will be given and the main components of the object models discussed. The main functionality of a first prototype will also be described. An overall view of the collaboration's structure and strategy will also be given. (author)

Development and Design of Next-Generation Head-Mounted Ambulatory Microdose Positron-Emission Tomography (AM-PET) System.

Science.gov (United States)

Melroy, Samantha; Bauer, Christopher; McHugh, Matthew; Carden, Garret; Stolin, Alexander; Majewski, Stan; Brefczynski-Lewis, Julie; Wuest, Thorsten

2017-05-19

Several applications exist for a whole brain positron-emission tomography (PET) brain imager designed as a portable unit that can be worn on a patient's head. Enabled by improvements in detector technology, a lightweight, high performance device would allow PET brain imaging in different environments and during behavioral tasks. Such a wearable system that allows the subjects to move their heads and walk-the Ambulatory Microdose PET (AM-PET)-is currently under development. This imager will be helpful for testing subjects performing selected activities such as gestures, virtual reality activities and walking. The need for this type of lightweight mobile device has led to the construction of a proof of concept portable head-worn unit that uses twelve silicon photomultiplier (SiPM) PET module sensors built into a small ring which fits around the head. This paper is focused on the engineering design of mechanical support aspects of the AM-PET project, both of the current device as well as of the coming next-generation devices. The goal of this work is to optimize design of the scanner and its mechanics to improve comfort for the subject by reducing the effect of weight, and to enable diversification of its applications amongst different research activities.

Development and Design of Next-Generation Head-Mounted Ambulatory Microdose Positron-Emission Tomography (AM-PET System

Directory of Open Access Journals (Sweden)

Samantha Melroy

2017-05-01

Full Text Available Several applications exist for a whole brain positron-emission tomography (PET brain imager designed as a portable unit that can be worn on a patient’s head. Enabled by improvements in detector technology, a lightweight, high performance device would allow PET brain imaging in different environments and during behavioral tasks. Such a wearable system that allows the subjects to move their heads and walk—the Ambulatory Microdose PET (AM-PET—is currently under development. This imager will be helpful for testing subjects performing selected activities such as gestures, virtual reality activities and walking. The need for this type of lightweight mobile device has led to the construction of a proof of concept portable head-worn unit that uses twelve silicon photomultiplier (SiPM PET module sensors built into a small ring which fits around the head. This paper is focused on the engineering design of mechanical support aspects of the AM-PET project, both of the current device as well as of the coming next-generation devices. The goal of this work is to optimize design of the scanner and its mechanics to improve comfort for the subject by reducing the effect of weight, and to enable diversification of its applications amongst different research activities.

The Advanced Gamma-ray Imaging System (AGIS): Next-generation Cherenkov telescopes array.

Science.gov (United States)

Vassiliev, Vladimir; AGIS Collaboration

2010-03-01

AGIS is a concept for a next-generation ground-based gamma-ray observatory in the energy range from 50 GeV to 200 TeV. AGIS is being designed to have significantly improved sensitivity, angular resolution, and reliability of operation relative to the present generation instruments such as VERITAS and H.E.S.S. The novel technologies of AGIS are expected to enable great advances in the understanding of the populations and physics of sources of high-energy gamma rays in the Milky Way (e.g. SNR, X-ray binaries, dense molecular clouds) and outside the Galaxy (e.g. AGN, GRBs, galaxy clusters, and star-forming galaxies). AGIS will complement and extend the results now being obtained in the GeV range with the Fermi mission providing wide energy coverage, superior angular resolution, and sensitivity to variability on short time scales. AGIS will be a key instrument for identifying and characterizing Fermi LAT sources. In this submission we outline the status of the development of AGIS project, design concept, and principal technologies. As illustrations of the scientific capabilities of AGIS, we review its potential to indirectly search for dark matter and measure cosmological magnetic fields.

Nuclear Energy Research Initiative (NERI): On-Line Intelligent Self-Diagnostic Monitoring for Next Generation Nuclear Plants - Phase I Annual Report

International Nuclear Information System (INIS)

Bond, L.G.; Doctor, S.R.; Gilbert, R.W.; Jarrell, D.B.; Greitzer, F.L.; Meador, R.J.

2000-01-01

OAK-B135 This OSTI ID belongs to an IWO and is being released out of the system. The Program Manager Rebecca Richardson has confirmed that all reports have been received. The objective of this project is to design and demonstrate the operation of the real-time intelligent self-diagnostic and prognostic system for next generation nuclear power plant systems. This new self-diagnostic technology is titled, ''On-Line Intelligent Self-Diagnostic Monitoring System'' (SDMS). This project provides a proof-of-principle technology demonstration for SDMS on a pilot plant scale service water system, where a distributed array of sensors is integrated with active components and passive structures typical of next generation nuclear power reactor and plant systems. This project employs state-of-the-art sensors, instrumentation, and computer processing to improve the monitoring and assessment of the power reactor system and to provide diagnostic and automated prognostics capabilities

Towards Next Generation Internet Management:CNGI-CERNET2EXPERIENCES

Institute of Scientific and Technical Information of China (English)

Jia-Hai Yang; Hui Zhang; Jin-Xiang Zhang; Chang-Qing An

2009-01-01

Manageability is an important feature of next generation Internet; management and monitoring of IPv6-based networks are proving a big challenge. While leveraging current IPv4-based SNMP management scheme to IPv6 networks'management need is necessary, it is more urgent to coin a new network management architecture to accommodate the scalability and extensibility requirements of next generation Internet management. The paper proposes a novel network management architecture, IMN (Internet Management Network), which creates an overlay network of management nodes.While each management node can perform management tasks autonomously and independently, it can finish more sophis-ticated management tasks by collaboratively invoking management operations or sharing information provided by other management nodes. P2P-based communication services are introduced in IMN to enable such collaboration. The paper presents a prototyping implementation based on the Web service related technology, as well as some of the key technologies,especially solutions to those issues arising from the management practice of CERNET2. Experiences of deployment of CERNET2 operation and lessons learned from the management practice are discussed.

Feasibility of a next generation underground water Cherenkov detector: UNO

International Nuclear Information System (INIS)

Jung, Chang Kee

2000-01-01

The feasibility of a next generation underground water Cherenkov detector is examined and a conceptual design (UNO) is presented. The design has a linear detector configuration with a total volume of 650 kton which is 13 times the total volume of the Super-Kamiokande detector. It corresponds to a 20 times increase in fiducial volume for physics analysis. The physics goals of UNO are to increase the sensitivity of the search for nucleon decay by a factor of ten and to make precision measurements of the solar and atmospheric neutrino properties. In addition, the detection sensitivity for supernova neutrinos will reach as far as the Andromeda galaxy

Next Generation Science Partnerships

Science.gov (United States)

Magnusson, J.

2016-02-01

I will provide an overview of the Next Generation Science Standards (NGSS) and demonstrate how scientists and educators can use these standards to strengthen and enhance their collaborations. The NGSS are rich in content and practice and provide all students with an internationally-benchmarked science education. Using these state-led standards to guide outreach efforts can help develop and sustain effective and mutually beneficial teacher-researcher partnerships. Aligning outreach with the three dimensions of the standards can help make research relevant for target audiences by intentionally addressing the science practices, cross-cutting concepts, and disciplinary core ideas of the K-12 science curriculum that drives instruction and assessment. Collaborations between researchers and educators that are based on this science framework are more sustainable because they address the needs of both scientists and educators. Educators are better able to utilize science content that aligns with their curriculum. Scientists who learn about the NGSS can better understand the frameworks under which educators work, which can lead to more extensive and focused outreach with teachers as partners. Based on this model, the International Ocean Discovery Program (IODP) develops its education materials in conjunction with scientists and educators to produce accurate, standards-aligned activities and curriculum-based interactions with researchers. I will highlight examples of IODP's current, successful teacher-researcher collaborations that are intentionally aligned with the NGSS.

Field-Distortion Air-Insulated Switches for Next-Generation Pulsed-Power Accelerators

Energy Technology Data Exchange (ETDEWEB)

Wisher, Matthew Louis [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Johns, Owen M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Breden, Eric Wayne [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Calhoun, Jacob Daniel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gruner, Frederick Rusticus [Kinetech LLC, Cedar Crest, NM (United States); Hohlfelder, Robert James [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Mulville, Thomas D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Muron, David J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Stoltzfus, Brian S. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Stygar, William A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-09-01

We have developed two advanced designs of a field-distortion air-insulated spark-gap switch that reduce the size of a linear-transformer-driver (LTD) brick. Both designs operate at 200 kV and a peak current of ~50 kA. At these parameters, both achieve a jitter of less than 2 ns and a prefire rate of ~0.1% over 5000 shots. We have reduced the number of switch parts and assembly steps, which has resulted in a more uniform, design-driven assembly process. We will characterize the performance of tungsten-copper and graphite electrodes, and two different electrode geometries. The new switch designs will substantially improve the electrical and operational performance of next-generation pulsed-power accelerators.

Towards the next generation of simplified Dark Matter models

Science.gov (United States)

Albert, Andreas; Bauer, Martin; Brooke, Jim; Buchmueller, Oliver; Cerdeño, David G.; Citron, Matthew; Davies, Gavin; de Cosa, Annapaola; De Roeck, Albert; De Simone, Andrea; Du Pree, Tristan; Flaecher, Henning; Fairbairn, Malcolm; Ellis, John; Grohsjean, Alexander; Hahn, Kristian; Haisch, Ulrich; Harris, Philip C.; Khoze, Valentin V.; Landsberg, Greg; McCabe, Christopher; Penning, Bjoern; Sanz, Veronica; Schwanenberger, Christian; Scott, Pat; Wardle, Nicholas

2017-06-01

This White Paper is an input to the ongoing discussion about the extension and refinement of simplified Dark Matter (DM) models. It is not intended as a comprehensive review of the discussed subjects, but instead summarises ideas and concepts arising from a brainstorming workshop that can be useful when defining the next generation of simplified DM models (SDMM). In this spirit, based on two concrete examples, we show how existing SDMM can be extended to provide a more accurate and comprehensive framework to interpret and characterise collider searches. In the first example we extend the canonical SDMM with a scalar mediator to include mixing with the Higgs boson. We show that this approach not only provides a better description of the underlying kinematic properties that a complete model would possess, but also offers the option of using this more realistic class of scalar mixing models to compare and combine consistently searches based on different experimental signatures. The second example outlines how a new physics signal observed in a visible channel can be connected to DM by extending a simplified model including effective couplings. In the next part of the White Paper we outline other interesting options for SDMM that could be studied in more detail in the future. Finally, we review important aspects of supersymmetric models for DM and use them to propose how to develop more complete SDMMs. This White Paper is a summary of the brainstorming meeting "Next generation of simplified Dark Matter models" that took place at Imperial College, London on May 6, 2016, and corresponding follow-up studies on selected subjects.

AugerNext: innovative research studies for the next generation ground-based ultra-high energy cosmic ray experiment

Directory of Open Access Journals (Sweden)

Haungs Andreas

2013-06-01

Full Text Available The findings so far of the Pierre Auger Observatory and also of the Telescope Array define the requirements for a possible next generation experiment: it needs to be considerably increased in size, it needs a better sensitivity to composition, and it should cover the full sky. AugerNext aims to perform innovative research studies in order to prepare a proposal fulfilling these demands. Such R&D studies are primarily focused in the following areas iconsolidation of the detection of cosmic rays using MHz radio antennas; iiproof-of-principle of cosmic-ray microwave detection; iiitest of the large-scale application of a new generation photo-sensors; ivgeneralization of data communication techniques; vdevelopment of new ways of muon detection with surface arrays. These AugerNext studies on new innovative detection methods for a next generation cosmic-ray experiment are performed at the Pierre Auger Observatory. The AugerNext consortium consists presently of fourteen partner institutions from nine European countries supported by a network of European funding agencies and it is a principal element of the ASPERA/ApPEC strategic roadmaps.

Methodology on the sparger development for Korean next generation reactor

International Nuclear Information System (INIS)

Kim, Hwan Yeol; Hwang, Y.D.; Kang, H.S.; Cho, B.H.; Park, J.K.

1999-06-01

In case of an accident, the safety depressurization system of Korean Next Generation Reactor (KNGR) efficiently depressurize the reactor pressure by directly discharge steam of high pressure and temperature from the pressurizer into the in-containment refuelling water storage tank (IRWST) through spargers. This report was generated for the purpose of developing the sparger of KNGR. This report presents the methodology on application of ABB-Atom. Many thermal hydraulic parameters affecting the maximum bubble could pressure were obtained and the maximum bubble cloud pressure transient curve so called forcing function of KNGR was suggested and design inputs for IRWST (bubble cloud radius vs. time, bubble cloud velocity vs. time, bubble cloud acceleration vs. time, etc.) were generated by the analytic using Rayleigh-Plesset equation. (author). 17 refs., 6 tabs., 27 figs

Methodology on the sparger development for Korean next generation reactor

Energy Technology Data Exchange (ETDEWEB)

Kim, Hwan Yeol; Hwang, Y.D.; Kang, H.S.; Cho, B.H.; Park, J.K

1999-06-01

In case of an accident, the safety depressurization system of Korean Next Generation Reactor (KNGR) efficiently depressurize the reactor pressure by directly discharge steam of high pressure and temperature from the pressurizer into the in-containment refuelling water storage tank (IRWST) through spargers. This report was generated for the purpose of developing the sparger of KNGR. This report presents the methodology on application of ABB-Atom. Many thermal hydraulic parameters affecting the maximum bubble could pressure were obtained and the maximum bubble cloud pressure transient curve so called forcing function of KNGR was suggested and design inputs for IRWST (bubble cloud radius vs. time, bubble cloud velocity vs. time, bubble cloudacceleration vs. time, etc.) were generated by the analytic using Rayleigh-Plesset equation. (author). 17 refs., 6 tabs., 27 figs.

Next Generation Luminaire (NGL) Downlight Demonstration Project, Hilton Columbus Downtown

Energy Technology Data Exchange (ETDEWEB)

Davis, R. G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Perrin, T. E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2014-09-30

At the Hilton Columbus Downtown hotel in Ohio, DOE's Better Buildings Alliance conducted a demonstration of Next Generation Luminaires-winning downlights installed in all guest rooms and suites prior to the hotel's 2012 opening. After a post-occupancy assessment, the LED downlights not only provided the aesthetic appearance and dimming functionality desired, but also provided 50% energy savings relative to a comparable CFL downlight and enabled the lighting power to be more than 20% below that allowed by code.

Near-Range Receiver Unit of Next Generation PollyXT Used with Koldeway Aerosol Raman Lidar in Arctic

Science.gov (United States)

Stachlewska, Iwona S.; Markowicz, Krzysztof M.; Ritter, Christoph; Neuber, Roland; Heese, Birgit; Engelmann, Ronny; Linne, Holger

2016-06-01

The Near-range Aerosol Raman lidar (NARLa) receiver unit, that was designed to enhance the detection range of the NeXT generation PollyXT Aerosol-Depolarization-Raman (ADR) lidar of the University of Warsaw, was employed next the Koldeway Aerosol Raman Lidar (KARL) at the AWI-IPEV German-French station in Arctic during Spring 2015. Here we introduce shortly design of both lidars, the scheme of their installation next to each other, and preliminary results of observations aiming at arctic haze investigation by the lidars and the iCAP a set of particle counter and aethalometer installed under a tethered balloon.

Next Generation Campus Network Deployment Project Based on Softswitch

OpenAIRE

HU Feng; LIU Ziyan

2011-01-01

After analyzing the current networks of Guizhou University，we brought forward a scheme of next generation campus networks based on softswitch technology by choosing SoftX3000 switching system of HuaWei and provided the specific solution of accessing campus networks in this paper. It is proved that this scheme is feasible by using OPNET, which not only accomplished the integration of the PSTN and IP networks but also achieved the combining of voice services and data services.

On the ergodic capacity of legacy systems in the presence of next generation interference

KAUST Repository

Mahmood, Nurul Huda

2011-11-01

Next generation wireless systems facilitating better utilization of the scarce radio spectrum have emerged as a response to inefficient rigid spectrum assignment policies. These are comprised of intelligent radio nodes that opportunistically operate in the radio spectrum of existing legacy systems; yet unwanted interference at the legacy receivers is unavoidable. In order to design efficient next generation systems and to minimize their harmful consequences, it is necessary to realize their impact on the performance of legacy systems. In this work, a generalized framework for the ergodic capacity analysis of such legacy systems in the presence of interference from next generation systems is presented. The analysis is built around a model developed for the statistical representation of the interference at the legacy receivers, which is then used to evaluate the ergodic capacity of the legacy system. Moreover, this analysis is not limited to the context of legacy systems, and is in fact applicaple to any interference limited system. Findings of analytical performance analyses are confirmed through selected computer-based Monte-Carlo simulations. © 2011 IEEE.

Nucleic acid reactivity : challenges for next-generation semiempirical quantum models

OpenAIRE

Huang, Ming; Giese, Timothy J.; York, Darrin M.

2015-01-01

Semiempirical quantum models are routinely used to study mechanisms of RNA catalysis and phosphoryl transfer reactions using combined quantum mechanical/molecular mechanical methods. Herein, we provide a broad assessment of the performance of existing semiempirical quantum models to describe nucleic acid structure and reactivity in order to quantify their limitations and guide the development of next-generation quantum models with improved accuracy. Neglect of diatomic diffierential overlap (...

New materials for next-generation commercial transports

National Research Council Canada - National Science Library

Committee on New Materials for Advanced Civil Aircraft, Commission on Engineering and Technical Systems, National Research Council

... civil aircraft throughout their service life. The committee investigated the new materials and structural concepts that are likely to be incorporated into next generation commercial aircraft and the factors influencing application decisions...

Preparation of next generation set of group cross sections. 3

International Nuclear Information System (INIS)

Kaneko, Kunio

2002-03-01

This fiscal year, based on the examination result about the evaluation energy range of heavy element unresolved resonance cross sections, the upper energy limit of the energy range, where ultra-fine group cross sections are produced, was raised to 50 keV, and an improvement of the group cross section processing system was promoted. At the same time, reflecting the result of studies carried out till now, a function producing delayed neutron data was added to the general-purpose group cross section processing system , thus the preparation of general purpose group cross section processing system has been completed. On the other hand, the energy structure, data constitution and data contents of next generation group cross section set were determined, and the specification of a 151 groups next generation group cross section set was defined. Based on the above specification, a concrete library format of the next generation cross section set has been determined. After having carried out the above-described work, using the general-purpose group cross section processing system , which was complete in this study, with use of the JENDL-3. 2 evaluated nuclear data, the 151 groups next generation group cross section of 92 nuclides and the ultra fine group resonance cross section library for 29 nuclides have been prepared. Utilizing the 151 groups next generation group cross section set and the ultra-fine group resonance cross-section library, a bench mark test calculation of fast reactors has been performed by using an advanced lattice calculation code. It was confirmed, by comparing the calculation result with a calculation result of continuous energy Monte Carlo code, that the 151 groups next generation cross section set has sufficient accuracy. (author)

Design and implementation of flexible TWDM-PON with PtP WDM overlay based on WSS for next-generation optical access networks

Science.gov (United States)

Wu, Bin; Yin, Hongxi; Qin, Jie; Liu, Chang; Liu, Anliang; Shao, Qi; Xu, Xiaoguang

2016-09-01

Aiming at the increasing demand of the diversification services and flexible bandwidth allocation of the future access networks, a flexible passive optical network (PON) scheme combining time and wavelength division multiplexing (TWDM) with point-to-point wavelength division multiplexing (PtP WDM) overlay is proposed for the next-generation optical access networks in this paper. A novel software-defined optical distribution network (ODN) structure is designed based on wavelength selective switches (WSS), which can implement wavelength and bandwidth dynamical allocations and suits for the bursty traffic. The experimental results reveal that the TWDM-PON can provide 40 Gb/s downstream and 10 Gb/s upstream data transmission, while the PtP WDM-PON can support 10 GHz point-to-point dedicated bandwidth as the overlay complement system. The wavelengths of the TWDM-PON and PtP WDM-PON are allocated dynamically based on WSS, which verifies the feasibility of the proposed structure.

An Overview of Metallic Nanowire Networks, Promising Building Blocks for Next Generation Transparent Conductors: Emergence, Fundamentals and Challenges

Science.gov (United States)

Pirsalami, Sedigheh; Zebarjad, Seyed Mojtaba; Daneshmanesh, Habib

2017-08-01

Transparent conductors (TCs) have a wide range of applications in numerous electronic and optoelectronic devices. This review provides an overview of the emergence of metallic nanowire networks (MNNs) as promising building blocks for the next generation transparent conductors. The fundamental aspects, structure-property relations, fabrication techniques and the corresponding challenges are reviewed. Theoretical and experimental researches suggest that nanowires with smaller diameter, longer length and higher aspect ratio have higher performance. Yet, the development of an efficient synthesis technique for the production of MNNs has remained a challenge. The synthesis method is also crucial to the scalability and the commercial potential of these emerging TCs. The most promising techniques for the synthesis together with their advantages, limitations and the recent findings are here discussed. Finally, we will try to show the promising future research trends in MNNs to have an approach to design the next generation TCs.

Status and plans for the next generation magnetically immersed diodes on RITS

International Nuclear Information System (INIS)

Rovang, Dean; Kincy, Mark; Maenchen, John; Menge, Peter; Molina, Isidro; Olson, Craig; Welch, Dale; Oliver, Bryan; Ives, Harry; VanDeValde, David; Johnson, David L.; Lesch, Benny; Swenson, Chuck

2002-01-01

Sandia National Laboratories is investigating and developing high-dose, high-brightness flash radiographic sources. We are in the process of designing; fabricating and conducting engineering tests on the next-generation magnetically immersed electron diodes. These diodes employ unique, large-bore (80-110 mm), high-field (28-45 T), cryogenically-cooled solenoid magnets to help produce an intense electron beam from a needle-like cathode 'immersed' in the strong Bz field of the magnet. The diode designs and status of the engineering development are described. Later this year we plan to conduct experiments with these sources on the new Radiographic Integrated Test Stand (RITS), now in operation at Sandia. In its present three-stage configuration, RITS provides a 4-MV, 150-kA, 70-ns pulse to the diode. Fully three-dimensional particle in cell LSP code simulations are used to investigate relevant physics issues and the expected radiographic performance (spot size and dose) of this system. Preliminary results from these simulations are described

Nuclear Energy Research Initiative (NERI): On-Line Intelligent Self-Diagnostic Monitoring for Next Generation Nuclear Plants - Phase I Annual Report

Energy Technology Data Exchange (ETDEWEB)

L. J. Bond; S. R. Doctor; R. W. Gilbert; D. B. Jarrell; F. L. Greitzer; R. J. Meador

2000-09-01

OAK-B135 This OSTI ID belongs to an IWO and is being released out of the system. The Program Manager Rebecca Richardson has confirmed that all reports have been received. The objective of this project is to design and demonstrate the operation of the real-time intelligent self-diagnostic and prognostic system for next generation nuclear power plant systems. This new self-diagnostic technology is titled, ''On-Line Intelligent Self-Diagnostic Monitoring System'' (SDMS). This project provides a proof-of-principle technology demonstration for SDMS on a pilot plant scale service water system, where a distributed array of sensors is integrated with active components and passive structures typical of next generation nuclear power reactor and plant systems. This project employs state-of-the-art sensors, instrumentation, and computer processing to improve the monitoring and assessment of the power reactor system and to provide diagnostic and automated prognostics capabilities.

Perspectives of Integrative Cancer Genomics in Next Generation Sequencing Era

Directory of Open Access Journals (Sweden)

So Mee Kwon

2012-06-01

Full Text Available The explosive development of genomics technologies including microarrays and next generation sequencing (NGS has provided comprehensive maps of cancer genomes, including the expression of mRNAs and microRNAs, DNA copy numbers, sequence variations, and epigenetic changes. These genome-wide profiles of the genetic aberrations could reveal the candidates for diagnostic and/or prognostic biomarkers as well as mechanistic insights into tumor development and progression. Recent efforts to establish the huge cancer genome compendium and integrative omics analyses, so-called "integromics", have extended our understanding on the cancer genome, showing its daunting complexity and heterogeneity. However, the challenges of the structured integration, sharing, and interpretation of the big omics data still remain to be resolved. Here, we review several issues raised in cancer omics data analysis, including NGS, focusing particularly on the study design and analysis strategies. This might be helpful to understand the current trends and strategies of the rapidly evolving cancer genomics research.

Reducing Risk for the Next Generation Nuclear Plant

Energy Technology Data Exchange (ETDEWEB)

John M. Beck II; Harold J. Heydt; Emmanuel O. Opare; Kyle B. Oswald

2010-07-01

The Next Generation Nuclear Plant (NGNP) Project, managed by the Idaho National Laboratory (INL), is directed by the Energy Policy Act of 2005, to research, develop, design, construct, and operate a prototype forth generation nuclear reactor to meet the needs of the 21st Century. As with all large projects developing and deploying new technologies, the NGNP has numerous risks that need to be identified, tracked, mitigated, and reduced in order for successful project completion. A Risk Management Plan (RMP) was created to outline the process the INL is using to manage the risks and reduction strategies for the NGNP Project. Integral to the RMP is the development and use of a Risk Management System (RMS). The RMS is a tool that supports management and monitoring of the project risks. The RMS does not only contain a risk register, but other functionality that allows decision makers, engineering staff, and technology researchers to review and monitor the risks as the project matures.

Modular EUV Source for the next generation lithography

International Nuclear Information System (INIS)

Sublemontier, O.; Rosset-Kos, M.; Ceccotti, T.; Hergott, J.F.; Auguste, Th.; Normand, D.; Schmidt, M.; Beaumont, F.; Farcage, D.; Cheymol, G.; Le Caro, J.M.; Cormont, Ph.; Mauchien, P.; Thro, P.Y.; Skrzypczak, J.; Muller, S.; Marquis, E.; Barthod, B.; Gaurand, I.; Davenet, M.; Bernard, R.

2011-01-01

The present work, performed in the frame of the EXULITE project, was dedicated to the design and characterization of a laser-plasma-produced extreme ultraviolet (EUV) source prototype at 13.5 nm for the next generation lithography. It was conducted in cooperation with two laboratories from CEA, ALCATEL and THALES. One of our approach originalities was the laser scheme modularity. Six Nd:YAG laser beams were focused at the same time on a xenon filament jet to generate the EUV emitting plasma. Multiplexing has important industrial advantages and led to interesting source performances in terms of in-band power, stability and angular emission properties with the filament jet target. A maximum conversion efficiency (CE) value of 0.44% in 2π sr and 2% bandwidth was measured, which corresponds to a maximum in band EUV mean power of 7.7 W at a repetition rate of 6 kHz. The EUV emission was found to be stable and isotropic in these conditions. (authors)

Reducing Risk for the Next Generation Nuclear Plant

International Nuclear Information System (INIS)

Beck, John M. II; Heydt, Harold J.; Opare, Emmanuel O.; Oswald, Kyle B.

2010-01-01

The Next Generation Nuclear Plant (NGNP) Project, managed by the Idaho National Laboratory (INL), is directed by the Energy Policy Act of 2005, to research, develop, design, construct, and operate a prototype forth generation nuclear reactor to meet the needs of the 21st Century. As with all large projects developing and deploying new technologies, the NGNP has numerous risks that need to be identified, tracked, mitigated, and reduced in order for successful project completion. A Risk Management Plan (RMP) was created to outline the process the INL is using to manage the risks and reduction strategies for the NGNP Project. Integral to the RMP is the development and use of a Risk Management System (RMS). The RMS is a tool that supports management and monitoring of the project risks. The RMS does not only contain a risk register, but other functionality that allows decision makers, engineering staff, and technology researchers to review and monitor the risks as the project matures.

Career Advancement: Meeting the Challenges Confronting the Next Generation of Endocrinologists and Endocrine Researchers.

Science.gov (United States)

Santen, Richard J; Joham, Anju; Fishbein, Lauren; Vella, Kristen R; Ebeling, Peter R; Gibson-Helm, Melanie; Teede, Helena

2016-12-01

Challenges and opportunities face the next generation (Next-Gen) of endocrine researchers and clinicians, the lifeblood of the field of endocrinology for the future. A symposium jointly sponsored by The Endocrine Society and the Endocrine Society of Australia was convened to discuss approaches to addressing the present and future Next-Gen needs. Data collection by literature review, assessment of previously completed questionnaires, commissioning of a new questionnaire, and summarization of symposium discussions were studied. Next-Gen endocrine researchers face diminishing grant funding in inflation-adjusted terms. The average age of individuals being awarded their first independent investigator funding has increased to age 45 years. For clinicians, a workforce gap exists between endocrinologists needed and those currently trained. Clinicians in practice are increasingly becoming employees of integrated hospital systems, resulting in greater time spent on nonclinical issues. Workforce data and published reviews identify challenges specifically related to early career women in endocrinology. Strategies to Address Issues: Recommendations encompassed the areas of grant support for research, mentoring, education, templates for career development, specific programs for Next-Gen members by senior colleagues as outlined in the text, networking, team science, and life/work integration. Endocrine societies focusing on Next-Gen members provide a powerful mechanism to support these critical areas. A concerted effort to empower, train, and support the next generation of clinical endocrinologists and endocrine researchers is necessary to ensure the viability and vibrancy of our discipline and to optimize our contributions to improving health outcomes. Collaborative engagement of endocrine societies globally will be necessary to support our next generation moving forward.

Unbundling in Current Broadband and Next-Generation Ultra-Broadband Access Networks

Science.gov (United States)

Gaudino, Roberto; Giuliano, Romeo; Mazzenga, Franco; Valcarenghi, Luca; Vatalaro, Francesco

2014-05-01

This article overviews the methods that are currently under investigation for implementing multi-operator open-access/shared-access techniques in next-generation access ultra-broadband architectures, starting from the traditional "unbundling-of-the-local-loop" techniques implemented in legacy twisted-pair digital subscriber line access networks. A straightforward replication of these copper-based unbundling-of-the-local-loop techniques is usually not feasible on next-generation access networks, including fiber-to-the-home point-to-multipoint passive optical networks. To investigate this issue, the article first gives a concise description of traditional copper-based unbundling-of-the-local-loop solutions, then focalizes on both next-generation access hybrid fiber-copper digital subscriber line fiber-to-the-cabinet scenarios and on fiber to the home by accounting for the mix of regulatory and technological reasons driving the next-generation access migration path, focusing mostly on the European situation.

Near-Range Receiver Unit of Next Generation PollyXT Used with Koldeway Aerosol Raman Lidar in Arctic

Directory of Open Access Journals (Sweden)

Stachlewska Iwona S.

2016-01-01

Full Text Available The Near-range Aerosol Raman lidar (NARLa receiver unit, that was designed to enhance the detection range of the NeXT generation PollyXT Aerosol-Depolarization-Raman (ADR lidar of the University of Warsaw, was employed next the Koldeway Aerosol Raman Lidar (KARL at the AWI-IPEV German-French station in Arctic during Spring 2015. Here we introduce shortly design of both lidars, the scheme of their installation next to each other, and preliminary results of observations aiming at arctic haze investigation by the lidars and the iCAP a set of particle counter and aethalometer installed under a tethered balloon.

Mobile e-Learning for Next Generation Communication Environment

Science.gov (United States)

Wu, Tin-Yu; Chao, Han-Chieh

2008-01-01

This article develops an environment for mobile e-learning that includes an interactive course, virtual online labs, an interactive online test, and lab-exercise training platform on the fourth generation mobile communication system. The Next Generation Learning Environment (NeGL) promotes the term "knowledge economy." Inter-networking…

Assessment of U.S. Manufacturing Capability for Next-Generation Wind Turbine Drivetrains

Energy Technology Data Exchange (ETDEWEB)

Cotrell, J. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Stelhy, T. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2013-09-01

Robust U.S. wind turbine manufacturing capabilities and supply chains are important for the United States to reduce the cost of electricity generated from wind turbines. These capabilities and supply chains are also critical to the invention and commercialization of new wind turbine technologies while providing high-quality jobs. The development of advanced drivetrain technologies for windturbine applications is advancing the state of the art for drivetrain design by producing higher capacity and operating reliability than conventional drivetrains. Advanced drivetrain technologies such as medium-speed and direct-drive generators, silicon-carbide (SiC) IGBT-based power electronics, and high torque density speed increasers require different manufacturing and supply chaincapabilities that present both risks and opportunities for U.S. wind turbine manufacturers and the wind industry as a whole. The primary objective of this project is to assess how advanced drivetrain technologies and trends will impact U.S. wind turbine manufacturing and its supply chains. The U.S. Department of Energy and other industry participants will use the information from this study toidentify domestic manufacturing gaps, barriers, and opportunities for developing U.S. wind turbine manufacturing capabilities and supply chains for next-generation drivetrain technologies. This report also includes recommendations for prioritizing technology areas for possible investments by public, private, or nonprofit entities that will reduce the cost of wind-generated electricity. Suchinvestments foster opportunities to invent and commercialize new wind turbine technologies, and provide high-quality jobs in the United States.

Tracing the Baryon Cycle within Nearby Galaxies with a next-generation VLA

Science.gov (United States)

Kepley, Amanda A.; Leroy, Adam; Murphy, Eric J.; ngVLA Baryon Cycle Science Working Group

2017-01-01

The evolution of galaxies over cosmic time is shaped by the cycling of baryons through these systems, namely the inflow of atomic gas, the formation of molecular structures, the birth of stars, and the expulsion of gas due to associated feedback processes. The best way to study this cycle in detail are observations of nearby galaxies. These systems provide a complete picture of baryon cycling over a wide range of astrophysical conditions. In the next decade, higher resolution/sensitivity observations of such galaxies will fundamentally improve our knowledge of galaxy formation and evolution, allowing us to better interpret higher redshift observations of sources that were rapidly evolving at epochs soon after the Big Bang. In particular, the centimeter-to-millimeter part of the spectrum provides critical diagnostics for each of the key baryon cycling processes and access to almost all phases of gas in galaxies: cool and cold gas (via emission and absorption lines), ionized gas (via free-free continuum and recombination lines), cosmic rays and hot gas (via synchrotron emission and the Sunyaev-Zeldovich effect). This poster highlights a number of key science problems in this area whose solutions require a next-generation radio-mm interferometer such as the next-generation VLA.

Environmental Information for the U.S. Next Generation Air Transportation System (NextGen)

Science.gov (United States)

Murray, J.; Miner, C.; Pace, D.; Minnis, P.; Mecikalski, J.; Feltz, W.; Johnson, D.; Iskendarian, H.; Haynes, J.

2009-09-01

It is estimated that weather is responsible for approximately 70% of all air traffic delays and cancellations in the United States. Annually, this produces an overall economic loss of nearly 40B. The FAA and NASA have determined that weather impacts and other environmental constraints on the U.S. National Airspace System (NAS) will increase to the point of system unsustainability unless the NAS is radically transformed. A Next Generation Air Transportation System (NextGen) is planned to accommodate the anticipated demand for increased system capacity and the super-density operations that this transformation will entail. The heart of the environmental information component that is being developed for NextGen will be a 4-dimensional data cube which will include a single authoritative source comprising probabilistic weather information for NextGen Air Traffic Management (ATM) systems. Aviation weather constraints and safety hazards typically comprise meso-scale, storm-scale and microscale observables that can significantly impact both terminal and enroute aviation operations. With these operational impacts in mind, functional and performance requirements for the NextGen weather system were established which require significant improvements in observation and forecasting capabilities. This will include satellite observations from geostationary and/or polar-orbiting hyperspectral sounders, multi-spectral imagers, lightning mappers, space weather monitors and other environmental observing systems. It will also require improved in situ and remotely sensed observations from ground-based and airborne systems. These observations will be used to better understand and to develop forecasting applications for convective weather, in-flight icing, turbulence, ceilings and visibility, volcanic ash, space weather and the environmental impacts of aviation. Cutting-edge collaborative research efforts and results from NASA, NOAA and the FAA which address these phenomena are summarized

Reprint of "Application of next generation sequencing in clinical microbiology and infection prevention"

NARCIS (Netherlands)

Deurenberg, Ruud H.; Bathoorn, Erik; Chlebowicz, Monika A.; Monge Gomes do Couto, Natacha; Ferdous, Mithila; Garcia-Cobos, Silvia; Kooistra-Smid, Anna M. D.; Raangs, Erwin C.; Rosema, Sigrid; Veloo, Alida C. M.; Zhou, Kai; Friedrich, Alexander W.; Rossen, John W. A.

2017-01-01

Current molecular diagnostics of human pathogens provide limited information that is often not sufficient for outbreak and transmission investigation. Next generation sequencing (NGS) determines the DNA sequence of a complete bacterial genome in a single sequence run, and from these data,

Towards Next Generation BI Systems

DEFF Research Database (Denmark)

Varga, Jovan; Romero, Oscar; Pedersen, Torben Bach

2014-01-01

Next generation Business Intelligence (BI) systems require integration of heterogeneous data sources and a strong user-centric orientation. Both needs entail machine-processable metadata to enable automation and allow end users to gain access to relevant data for their decision making processes....... This framework is based on the findings of a survey of current user-centric approaches mainly focusing on query recommendation assistance. Finally, we discuss the benefits of the framework and present the plans for future work....

Report on the September 2011 Meeting of the Next Generation Safegaurds Professional Network

Energy Technology Data Exchange (ETDEWEB)

Gitau, Ernest TN; Benz, Jacob M.

2011-12-19

The Next Generation Safeguards Professional Network (NGSPN) was established in 2009 by Oak Ridge National Laboratory targeted towards the engagement of young professionals employed in safeguards across the many national laboratories. NGSPN focuses on providing a mechanism for young safeguards professionals to connect and foster professional relationships, facilitating knowledge transfer between current safeguards experts and the next generation of experts, and acting as an entity to represent the interests of the international community of young and mid-career safeguards professionals. This is accomplished in part with a yearly meeting held at a national laboratory site. In 2011, this meeting was held at Pacific Northwest National Laboratory. This report documents the events and results of that meeting.

Application of photonics in next generation telecommunication satellites payloads

Science.gov (United States)

Anzalchi, J.; Inigo, P.; Roy, B.

2017-11-01

Next generation broadband telecommunication satellites are required to provide very high data throughput using complex multibeam architectures. These high throughput `Terabit/s' Satellites will incorporate payloads with very large quantity of conventional RF equipment, co-axial cables, waveguides, harnesses and ancillary equipment, making the Assembly, Integration and Test (AIT) very complex. Use of `RF over Fiber' and associated photonics equipment can make the process of AIT much simpler with the added benefit of significant reduction in number of payload equipment and inherent payload mass.

Data Analysis and Next Generation Assessments

Science.gov (United States)

Pon, Kathy

2013-01-01

For the last decade, much of the work of California school administrators has been shaped by the accountability of the No Child Left Behind Act. Now as they stand at the precipice of Common Core Standards and next generation assessments, it is important to reflect on the proficiency educators have attained in using data to improve instruction and…

A Next Generation Light Source Facility at LBNL

Energy Technology Data Exchange (ETDEWEB)

Corlett, J.N.; Austin, B.; Baptiste, K.M.; Byrd, J.M.; Denes, P.; Donahue, R.; Doolittle, L.; Falcone, R.W.; Filippetto, D.; Fournier, S.; Li, D.; Padmore, H.A.; Papadopoulos, C.; Pappas, C.; Penn, G.; Placidi, M.; Prestemon, S.; Prosnitz, D.; Qiang, J.; Ratti, A.; Reinsch, M.; Sannibale, F.; Schlueter, R.; Schoenlein, R.W.; Staples, J.W.; Vecchione, T.; Venturini, M.; Wells, R.; Wilcox, R.; Wurtele, J.; Charman, A.; Kur, E.; Zholents, A.A.

2011-03-23

The Next Generation Light Source (NGLS) is a design concept, under development at LBNL, for a multibeamline soft x-ray FEL array powered by a ~;;2 GeV superconducting linear accelerator, operating with a 1 MHz bunch repetition rate. The CW superconducting linear accelerator is supplied by a high-brightness, highrepetition- rate photocathode electron gun. Electron bunches are distributed from the linac to the array of independently configurable FEL beamlines with nominal bunch rates up to 100 kHz in each FEL, and with even pulse spacing. Individual FELs may be configured for EEHG, HGHG, SASE, or oscillator mode of operation, and will produce high peak and average brightness x-rays with a flexible pulse format, with pulse durations ranging from sub-femtoseconds to hundreds of femtoseconds.

Achieving universal access to next generation networks

DEFF Research Database (Denmark)

Falch, Morten; Henten, Anders

The paper examines investment dimensions of next generation networks in a universal service perspective in a European context. The question is how new network infrastructures for getting access to communication, information and entertainment services in the present and future information society...

Direct target NOTES: prospective applications for next generation robotic platforms.

Science.gov (United States)

Atallah, S; Hodges, A; Larach, S W

2018-05-01

A new era in surgical robotics has centered on alternative access to anatomic targets and next generation designs include flexible, single-port systems which follow circuitous rather than straight pathways. Such systems maintain a small footprint and could be utilized for specialized operations based on direct organ target natural orifice transluminal endoscopic surgery (NOTES), of which transanal total mesorectal excision (taTME) is an important derivative. During two sessions, four direct target NOTES operations were conducted on a cadaveric model using a flexible robotic system to demonstrate proof-of-concept of the application of a next generation robotic system to specific types of NOTES operations, all of which required removal of a direct target organ through natural orifice access. These four operations were (a) robotic taTME, (b) robotic transvaginal hysterectomy in conjunction with (c) robotic transvaginal salpingo-oophorectomy, and in an ex vivo model, (d) trans-cecal appendectomy. Feasibility was demonstrated in all cases using the Flex ® Robotic System with Colorectal Drive. During taTME, the platform excursion was 17 cm along a non-linear path; operative time was 57 min for the transanal portion of the dissection. Robotic transvaginal hysterectomy was successfully completed in 78 min with transvaginal extraction of the uterus, although laparoscopic assistance was required. Robotic transvaginal unilateral salpingo-oophorectomy with transvaginal extraction of the ovary and fallopian tube was performed without laparoscopic assistance in 13.5 min. In an ex vivo model, a robotic trans-cecal appendectomy was also successfully performed for the purpose of demonstrating proof-of-concept only; this was completed in 24 min. A flexible robotic system has the potential to access anatomy along circuitous paths, making it a suitable platform for direct target NOTES. The conceptual operations posed could be considered suitable for next generation robotics once

Digital Earth reloaded - Beyond the next generation

Science.gov (United States)

Ehlers, M.; Woodgate, P.; Annoni, A.; Schade, S.

2014-02-01

Digital replicas (or 'mirror worlds') of complex entities and systems are now routine in many fields such as aerospace engineering; archaeology; medicine; or even fashion design. The Digital Earth (DE) concept as a digital replica of the entire planet occurs in Al Gore's 1992 book Earth in the Balance and was popularized in his speech at the California Science Center in January 1998. It played a pivotal role in stimulating the development of a first generation of virtual globes, typified by Google Earth that achieved many elements of this vision. Almost 15 years after Al Gore's speech, the concept of DE needs to be re-evaluated in the light of the many scientific and technical developments in the fields of information technology, data infrastructures, citizen?s participation, and earth observation that have taken place since. This paper intends to look beyond the next generation predominantly based on the developments of fields outside the spatial sciences, where concepts, software, and hardware with strong relationships to DE are being developed without referring to this term. It also presents a number of guiding criteria for future DE developments.

Validation of Metagenomic Next-Generation Sequencing Tests for Universal Pathogen Detection.

Science.gov (United States)

Schlaberg, Robert; Chiu, Charles Y; Miller, Steve; Procop, Gary W; Weinstock, George

2017-06-01

- Metagenomic sequencing can be used for detection of any pathogens using unbiased, shotgun next-generation sequencing (NGS), without the need for sequence-specific amplification. Proof-of-concept has been demonstrated in infectious disease outbreaks of unknown causes and in patients with suspected infections but negative results for conventional tests. Metagenomic NGS tests hold great promise to improve infectious disease diagnostics, especially in immunocompromised and critically ill patients. - To discuss challenges and provide example solutions for validating metagenomic pathogen detection tests in clinical laboratories. A summary of current regulatory requirements, largely based on prior guidance for NGS testing in constitutional genetics and oncology, is provided. - Examples from 2 separate validation studies are provided for steps from assay design, and validation of wet bench and bioinformatics protocols, to quality control and assurance. - Although laboratory and data analysis workflows are still complex, metagenomic NGS tests for infectious diseases are increasingly being validated in clinical laboratories. Many parallels exist to NGS tests in other fields. Nevertheless, specimen preparation, rapidly evolving data analysis algorithms, and incomplete reference sequence databases are idiosyncratic to the field of microbiology and often overlooked.

Next-Generation Sequencing: From Understanding Biology to Personalized Medicine

Directory of Open Access Journals (Sweden)

Benjamin Meder

2013-03-01

Full Text Available Within just a few years, the new methods for high-throughput next-generation sequencing have generated completely novel insights into the heritability and pathophysiology of human disease. In this review, we wish to highlight the benefits of the current state-of-the-art sequencing technologies for genetic and epigenetic research. We illustrate how these technologies help to constantly improve our understanding of genetic mechanisms in biological systems and summarize the progress made so far. This can be exemplified by the case of heritable heart muscle diseases, so-called cardiomyopathies. Here, next-generation sequencing is able to identify novel disease genes, and first clinical applications demonstrate the successful translation of this technology into personalized patient care.

Informing the next nuclear generation - how does the Ginna plant branch do it?

International Nuclear Information System (INIS)

Saavedra, A.

1995-01-01

Most of us are familiar with the latest advertising phrase, ''Our children are our future.'' This phrase has been used in so many instances - from concerns about waste, Social Security, and the federal deficit to drug abuse and violence. One more area can be added to the list and advertised nuclear power. Since the establishment of the Ginna plant branch (GPB) in 1992, our target audience has been the next nuclear generation (our children), but our vehicle for dissemination has been the current generation (the adults). Have you ever thought about how often your opinions affect the children you come in contact with? One of GPB's goals is to provide as much information as possible to teachers, neighbors, and civic organizations of our community so that there is a nuclear future that can be carried on by the next generation

Development of digital plant protection system for Korean Next Generation Reactor

International Nuclear Information System (INIS)

Suk-Joon Park

1998-01-01

A Digital Plant Protection System (DPPS) for Korean Next Generation Reactor (KNGR) is being developed using the Programmable Logic Controller (PLC) technology. For the design verification, the development of the DPPS prototype is progressing at this time. The prototype hardware equipment is installed and software coding is started. DPPS software is being coded by strict software V and V activities and function block language that uses simple graphical symbols. By adopting the PLC technology, the design of DPPS is possible to take full advantages in areas such as automatic testing, simplified calibration, improved isolation between redundant channels, reduced internal and external wiring and increased plant availability. (author)

Tying the knot with next-generation reactors: Can the industry afford a second marriage?

International Nuclear Information System (INIS)

Anon.

1993-01-01

This article examines the future of nuclear power beyond the year 2000. The nuclear industry just celebrated 50 years of nuclear technology, but no new plants have been ordered in the US since 1978 and some European countries are giving up on the nuclear option. This article discusses the four US advanced light-water reactor design and safety features, specific design features and parameters for the advanced designs, advanced designs from Europe, features utilities look for in a reactor, evolutionary versus passive designs, gaining public acceptance for new designs, and what alternatives are there to installing next-generation nuclear systems?

Next Linear Collider Test Accelerator conceptual design report

International Nuclear Information System (INIS)

1993-08-01

This document presents the scientific justification and the conceptual design for the open-quotes Next Linear Collider Test Acceleratorclose quotes (NLCTA) at SLAC. The goals of the NLCTA are to integrate the new technologies of X-band accelerator structures and rf systems being developed for the Next Linear Collider, to measure the growth of the open-quotes dark currentclose quotes generated by rf field emission in the accelerator, to demonstrate multi-bunch beam-loading energy compensation and suppression of higher-order deflecting modes, and to measure any transverse components of the accelerating field. The NLCTA will be a 42-meter-long beam line consisting, consecutively, of a thermionic-cathode gun, an X-band buncher, a magnetic chicane, six 1.8-meter-long sections of 11.4-GHz accelerator structure, and a magnetic spectrometer. Initially, the unloaded accelerating gradient will be 50 MV/m. A higher-gradient upgrade option eventually would increase the unloaded gradient to 100 MV/m

Advanced LIGO: the next generation of gravitational wave detectors

International Nuclear Information System (INIS)

Harry, Gregory M

2010-01-01

The Advanced LIGO gravitational wave detectors are next generation instruments which will replace the existing initial LIGO detectors. They are currently being constructed and installed. Advanced LIGO strain sensitivity is designed to be about a factor 10 better than initial LIGO over a broad band and usable to 10 Hz, in contrast to 40 Hz for initial LIGO. This is expected to allow for detections and significant astrophysics in most categories of gravitational waves. To achieve this sensitivity, all hardware subsystems are being replaced with improvements. Designs and expected performance are presented for the seismic isolation, suspensions, optics and laser subsystems. Possible enhancements to Advanced LIGO, either to resolve problems that may arise and/or to allow for improved performance, are now being researched. Some of these enhancements are discussed along with some potential technology being considered for detectors beyond Advanced LIGO.

NASA System-Level Design, Analysis and Simulation Tools Research on NextGen

Science.gov (United States)

Bardina, Jorge

2011-01-01

A review of the research accomplished in 2009 in the System-Level Design, Analysis and Simulation Tools (SLDAST) of the NASA's Airspace Systems Program is presented. This research thrust focuses on the integrated system-level assessment of component level innovations, concepts and technologies of the Next Generation Air Traffic System (NextGen) under research in the ASP program to enable the development of revolutionary improvements and modernization of the National Airspace System. The review includes the accomplishments on baseline research and the advancements on design studies and system-level assessment, including the cluster analysis as an annualization standard of the air traffic in the U.S. National Airspace, and the ACES-Air MIDAS integration for human-in-the-loop analyzes within the NAS air traffic simulation.

Next Generation Drivetrain Development and Test Program

Energy Technology Data Exchange (ETDEWEB)

Keller, Jonathan; Erdman, Bill; Blodgett, Doug; Halse, Chris; Grider, Dave

2015-11-03

This presentation was given at the Wind Energy IQ conference in Bremen, Germany, November 30 through December 2, 2105. It focused on the next-generation drivetrain architecture and drivetrain technology development and testing (including gearbox and inverter software and medium-voltage inverter modules.

Universal Intelligent Small Cell (UnISCell for next generation cellular networks

Directory of Open Access Journals (Sweden)

Mohammad Patwary

2016-11-01

Full Text Available Exploring innovative cellular architectures to achieve enhanced system capacity and good coverage has become a critical issue towards realizing the next generation of wireless communications. In this context, this paper proposes a novel concept of Universal Intelligent Small Cell (UnISCell for enabling the densification of the next generation of cellular networks. The proposed novel concept envisions an integrated platform of providing a strong linkage between different stakeholders such as street lighting networks, landline telephone networks and future wireless networks, and is universal in nature being independent of the operating frequency bands and traffic types. The main motivating factors for the proposed small cell concept are the need of public infrastructure re-engineering, and the recent advances in several enabling technologies. First, we highlight the main concepts of the proposed UnISCell platform. Subsequently, we present two deployment scenarios for the proposed UnISCell concept considering infrastructure sharing and service sharing as important aspects. We then describe the key future technologies for enabling the proposed UnISCell concept and present a use case example with the help of numerical results. Finally, we conclude this article by providing some interesting future recommendations.

Next-generation approaches to the microbial ecology of food fermentations

Directory of Open Access Journals (Sweden)

Nicholas A. Bokulich1,2,3 & David A. Mills1,2,3*

2012-07-01

Full Text Available Food fermentations have enhanced human health since the dawnof time and remain a prevalent means of food processing andpreservation. Due to their cultural and nutritional importance,many of these foods have been studied in detail using moleculartools, leading to enhancements in quality and safety. Furthermore,recent advances in high-throughput sequencing technologyare revolutionizing the study of food microbial ecology,deepening insight into complex fermentation systems. Thisreview provides insight into novel applications of selectmolecular techniques, particularly next-generation sequencingtechnology, for analysis of microbial communities in fermentedfoods. We present a guideline for integrated molecular analysis offood microbial ecology and a starting point for implementingnext-generation analysis of food systems.

Next Generation Geothermal Power Plants

Energy Technology Data Exchange (ETDEWEB)

Brugman, John; Hattar, Mai; Nichols, Kenneth; Esaki, Yuri

1995-09-01

cycle. Results of this study indicate that dual flash type plants are preferred at resources with temperatures above 400 F. Closed loop (binary type) plants are preferred at resources with temperatures below 400 F. A rotary separator turbine upstream of a dual flash plant can be beneficial at Salton Sea, the hottest resource, or at high temperature resources where there is a significant variance in wellhead pressures from well to well. Full scale demonstration is required to verify cost and performance. Hot water turbines that recover energy from the spent brine in a dual flash cycle improve that cycle's brine efficiency. Prototype field tests of this technology have established its technical feasibility. If natural gas prices remain low, a combustion turbine/binary hybrid is an economic option for the lowest temperature sites. The use of mixed fluids appear to be an attractive low risk option. The synchronous turbine option as prepared by Barber-Nichols is attractive but requires a pilot test to prove cost and performance. Dual flash binary bottoming cycles appear promising provided that scaling of the brine/working fluid exchangers is controllable. Metastable expansion, reheater, Subatmospheric flash, dual flash backpressure turbine, and hot dry rock concepts do not seem to offer any cost advantage over the baseline technologies. If implemented, the next generation geothermal power plant concept may improve brine utilization but is unlikely to reduce the cost of power generation by much more than 10%. Colder resources will benefit more from the development of a next generation geothermal power plant than will hotter resources. All values presented in this study for plant cost and for busbar cost of power are relative numbers intended to allow an objective and meaningful comparison of technologies. The goal of this study is to assess various technologies on an common basis and, secondarily, to give an approximate idea of the current costs of the technologies at

Network Restoration for Next-Generation Communication and Computing Networks

Directory of Open Access Journals (Sweden)

B. S. Awoyemi

2018-01-01

Full Text Available Network failures are undesirable but inevitable occurrences for most modern communication and computing networks. A good network design must be robust enough to handle sudden failures, maintain traffic flow, and restore failed parts of the network within a permissible time frame, at the lowest cost achievable and with as little extra complexity in the network as possible. Emerging next-generation (xG communication and computing networks such as fifth-generation networks, software-defined networks, and internet-of-things networks have promises of fast speeds, impressive data rates, and remarkable reliability. To achieve these promises, these complex and dynamic xG networks must be built with low failure possibilities, high network restoration capacity, and quick failure recovery capabilities. Hence, improved network restoration models have to be developed and incorporated in their design. In this paper, a comprehensive study on network restoration mechanisms that are being developed for addressing network failures in current and emerging xG networks is carried out. Open-ended problems are identified, while invaluable ideas for better adaptation of network restoration to evolving xG communication and computing paradigms are discussed.

Next Generation Driver for Attosecond and Laser-plasma Physics.

Science.gov (United States)

Rivas, D E; Borot, A; Cardenas, D E; Marcus, G; Gu, X; Herrmann, D; Xu, J; Tan, J; Kormin, D; Ma, G; Dallari, W; Tsakiris, G D; Földes, I B; Chou, S-W; Weidman, M; Bergues, B; Wittmann, T; Schröder, H; Tzallas, P; Charalambidis, D; Razskazovskaya, O; Pervak, V; Krausz, F; Veisz, L

2017-07-12

The observation and manipulation of electron dynamics in matter call for attosecond light pulses, routinely available from high-order harmonic generation driven by few-femtosecond lasers. However, the energy limitation of these lasers supports only weak sources and correspondingly linear attosecond studies. Here we report on an optical parametric synthesizer designed for nonlinear attosecond optics and relativistic laser-plasma physics. This synthesizer uniquely combines ultra-relativistic focused intensities of about 10 20  W/cm 2 with a pulse duration of sub-two carrier-wave cycles. The coherent combination of two sequentially amplified and complementary spectral ranges yields sub-5-fs pulses with multi-TW peak power. The application of this source allows the generation of a broad spectral continuum at 100-eV photon energy in gases as well as high-order harmonics in relativistic plasmas. Unprecedented spatio-temporal confinement of light now permits the investigation of electric-field-driven electron phenomena in the relativistic regime and ultimately the rise of next-generation intense isolated attosecond sources.

Evaluating the 'next generation' of cell salvage--will it make a difference?

Science.gov (United States)

Yarham, Gemma; Clements, Ann; Oliver, Martin; Morris, Christopher; Cumberland, Tom; Bryan, Megan; Jekler, Sasa; Johns, Kathy; Mulholland, John

2011-07-01

Donor blood supplies are diminishing, becoming more costly and these transfusions lead to higher mortality in cardiac patients. The transfusion risks and the literature highlight the need for an alternative similar to cell salvage to be routinely considered. The Xtra is the first cell saver to be launched since 2001 and will undoubtedly initiate evolution towards the 'next generation' of cell savers. It is also the first to be launched in a new era where the demand for electronic perfusion data management (EPDM) has grown. The user interface (UI) was easy to use. The increased data entry options improved the quality of the recordable data. The integrated data management system (DMS) was comprehensive. Data was easy to manage and enabled central data compilation, which reduces repeated data, the risk of inconsistent data inventory and provides the potential for research and analyses. The haematocrit of the processed blood is a key quality indicator for cell salvage. The comparison of the manufacturer's integrated protocol, Popt, to our team's own protocol showed that Popt delivered a higher haematocrit on its '1st bowl' (59.1% compared to 57.3%) and its 'total process' end product haematocrit was 0.68% higher. The Popt cycle took an average of 330s, whereas our own settings completed in just over 300s. The Xtra is a device which will lead the evolution of 'next generation' cell saver technology. The user interface and data management system provide export options and the ability to record the level of data required for good EPDM. This is essential to 'future proof' cell salvage technology. The manufacturer's integrated protocol achieved a higher end product haematocrit than our perfusion team's best practice. The design of the Xtra is contemporary, but the DMS equips this cell saver for the new era that faces both Perfusion and Cardiac Surgery.

76 FR 49776 - The Development and Evaluation of Next-Generation Smallpox Vaccines; Public Workshop

Science.gov (United States)

2011-08-11

...] The Development and Evaluation of Next-Generation Smallpox Vaccines; Public Workshop AGENCY: Food and... Evaluation of Next-Generation Smallpox Vaccines.'' The purpose of the public workshop is to identify and discuss the key issues related to the development and evaluation of next-generation smallpox vaccines. The...

Values Underpinning STEM Education in the USA: An Analysis of the Next Generation Science Standards

Science.gov (United States)

Hoeg, Darren G.; Bencze, John Lawrence

2017-01-01

The Next Generation Science Standards (NGSS) were designed to address poor science and math performance in United States schools by inculcating globally competitive science, technology, engineering, and mathematics literacies relevant to participation in future society. Considering the complex network of influences involved in the development of…

Next Generation Agricultural System Data, Models and Knowledge Products: Introduction

Science.gov (United States)

Antle, John M.; Jones, James W.; Rosenzweig, Cynthia E.

2016-01-01

Agricultural system models have become important tools to provide predictive and assessment capability to a growing array of decision-makers in the private and public sectors. Despite ongoing research and model improvements, many of the agricultural models today are direct descendants of research investments initially made 30-40 years ago, and many of the major advances in data, information and communication technology (ICT) of the past decade have not been fully exploited. The purpose of this Special Issue of Agricultural Systems is to lay the foundation for the next generation of agricultural systems data, models and knowledge products. The Special Issue is based on a 'NextGen' study led by the Agricultural Model Intercomparison and Improvement Project (AgMIP) with support from the Bill and Melinda Gates Foundation.

Targeted next-generation sequencing in monogenic dyslipidemias.

Science.gov (United States)

Hegele, Robert A; Ban, Matthew R; Cao, Henian; McIntyre, Adam D; Robinson, John F; Wang, Jian

2015-04-01

To evaluate the potential clinical translation of high-throughput next-generation sequencing (NGS) methods in diagnosis and management of dyslipidemia. Recent NGS experiments indicate that most causative genes for monogenic dyslipidemias are already known. Thus, monogenic dyslipidemias can now be diagnosed using targeted NGS. Targeting of dyslipidemia genes can be achieved by either: designing custom reagents for a dyslipidemia-specific NGS panel; or performing genome-wide NGS and focusing on genes of interest. Advantages of the former approach are lower cost and limited potential to detect incidental pathogenic variants unrelated to dyslipidemia. However, the latter approach is more flexible because masking criteria can be altered as knowledge advances, with no need for re-design of reagents or follow-up sequencing runs. Also, the cost of genome-wide analysis is decreasing and ethical concerns can likely be mitigated. DNA-based diagnosis is already part of the clinical diagnostic algorithms for familial hypercholesterolemia. Furthermore, DNA-based diagnosis is supplanting traditional biochemical methods to diagnose chylomicronemia caused by deficiency of lipoprotein lipase or its co-factors. The increasing availability and decreasing cost of clinical NGS for dyslipidemia means that its potential benefits can now be evaluated on a larger scale.

Applications of nanotechnology, next generation sequencing and microarrays in biomedical research.

Science.gov (United States)

Elingaramil, Sauli; Li, Xiaolong; He, Nongyue

2013-07-01

Next-generation sequencing technologies, microarrays and advances in bio nanotechnology have had an enormous impact on research within a short time frame. This impact appears certain to increase further as many biomedical institutions are now acquiring these prevailing new technologies. Beyond conventional sampling of genome content, wide-ranging applications are rapidly evolving for next-generation sequencing, microarrays and nanotechnology. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted re sequencing and discovery of transcription factor binding sites, noncoding RNA expression profiling and molecular diagnostics. This paper thus discusses current applications of nanotechnology, next-generation sequencing technologies and microarrays in biomedical research and highlights the transforming potential these technologies offer.

Combining real-time PCR and next-generation DNA sequencing to provide quantitative comparisons of fungal aerosol populations

Science.gov (United States)

Dannemiller, Karen C.; Lang-Yona, Naama; Yamamoto, Naomichi; Rudich, Yinon; Peccia, Jordan

2014-02-01

We examined fungal communities associated with the PM10 mass of Rehovot, Israel outdoor air samples collected in the spring and fall seasons. Fungal communities were described by 454 pyrosequencing of the internal transcribed spacer (ITS) region of the fungal ribosomal RNA encoding gene. To allow for a more quantitative comparison of fungal exposure in humans, the relative abundance values of specific taxa were transformed to absolute concentrations through multiplying these values by the sample's total fungal spore concentration (derived from universal fungal qPCR). Next, the sequencing-based absolute concentrations for Alternaria alternata, Cladosporium cladosporioides, Epicoccum nigrum, and Penicillium/Aspergillus spp. were compared to taxon-specific qPCR concentrations for A. alternata, C. cladosporioides, E. nigrum, and Penicillium/Aspergillus spp. derived from the same spring and fall aerosol samples. Results of these comparisons showed that the absolute concentration values generated from pyrosequencing were strongly associated with the concentration values derived from taxon-specific qPCR (for all four species, p 0.70). The correlation coefficients were greater for species present in higher concentrations. Our microbial aerosol population analyses demonstrated that fungal diversity (number of fungal operational taxonomic units) was higher in the spring compared to the fall (p = 0.02), and principal coordinate analysis showed distinct seasonal differences in taxa distribution (ANOSIM p = 0.004). Among genera containing allergenic and/or pathogenic species, the absolute concentrations of Alternaria, Aspergillus, Fusarium, and Cladosporium were greater in the fall, while Cryptococcus, Penicillium, and Ulocladium concentrations were greater in the spring. The transformation of pyrosequencing fungal population relative abundance data to absolute concentrations can improve next-generation DNA sequencing-based quantitative aerosol exposure assessment.

The Next Generation of the Montage Image Mopsaic Engine

Science.gov (United States)

Berriman, G. Bruce; Good, John; Rusholme, Ben; Robitaille, Thomas

2016-01-01

We have released a major upgrade of the Montage image mosaic engine (http://montage.ipac.caltech.edu) , as part of a program to develop the next generation of the engine in response to the rapid changes in the data processing landscape in Astronomy, which is generating ever larger data sets in ever more complex formats . The new release (version 4) contains modules dedicated to creating and managing mosaics of data stored as multi-dimensional arrays ("data cubes"). The new release inherits the architectural benefits of portability and scalability of the original design. The code is publicly available on Git Hub and the Montage web page. The release includes a command line tool that supports visualization of large images, and the beta-release of a Python interface to the visualization tool. We will provide examples on how to use these these features. We are generating a mosaic of the Galactic Arecibo L-band Feed Array HI (GALFA-HI) Survey maps of neutral hydrogen in and around our Milky Way Galaxy, to assess the performance at scale and to develop tools and methodologies that will enable scientists inexpert in cloud processing to exploit could platforms for data processing and product generation at scale. Future releases include support for an R-tree based mechanism for fast discovery of and access to large data sets and on-demand access to calibrated SDSS DR9 data that exploits it; support for the Hierarchical Equal Area isoLatitude Pixelization (HEALPix) scheme, now standard for projects investigating cosmic background radiation (Gorski et al 2005); support fort the Tessellated Octahedral Adaptive Subdivision Transform (TOAST), the sky partitioning sky used by the WorldWide Telescope (WWT); and a public applications programming interface (API) in C that can be called from other languages, especially Python.

An extendible software architecture for next generation multi-material AM platforms : design and implementation of a Recipe Maker as test case of the software architecture

NARCIS (Netherlands)

Seifu, G.N.

2017-01-01

Additive manufacturing (AM) is the process of joining building material layer by layer to make a product from a three-dimensional digital representation. It is also commonly called 3D printing. This project provides a software architecture for next generation 3D printers. At its current status, the

EIDA Next Generation: ongoing and future developments

Science.gov (United States)

Strollo, Angelo; Quinteros, Javier; Sleeman, Reinoud; Trani, Luca; Clinton, John; Stammler, Klaus; Danecek, Peter; Pedersen, Helle; Ionescu, Constantin

2015-04-01

The European Integrated Data Archive (EIDA; http://www.orfeus-eu.org/eida/eida.html) is the distributed Data Centre system within ORFEUS, providing transparent access and services to high quality, seismic data across (currently) 9 large data archives in Europe. EIDA is growing, in terms of the number of participating data centres, the size of the archives, the variability of the data in the archives, the number of users, and the volume of downloads. The on-going success of EIDA is thus providing challenges that are the driving force behind the design of the next generation (NG) of EIDA, which is expected to be implemented within EPOS IP. EIDA ORFEUS must cope with further expansion of the system and more complex user requirements by developing new techniques and extended services. The EIDA NG is being designed to work on standard FDSN web services and two additional new web services: Routing Service and QC (quality controlled) service. This presentation highlights the challenges EIDA needs to address during the EPOS IP and focuses on these 2 new services. The Routing Service can be considered as the core of EIDA NG. It was designed to assist users and clients to locate data within a federated, decentralized data centre (e.g. EIDA). A detailed, FDSN-compliant specification of the service has been developed. Our implementation of this service will run at every EIDA node, but is also capable of running on a user's computer, allowing anyone to define virtual or integrate existing data centres. This (meta)service needs to be queried in order to locate the data. Some smart clients (in a beta status) have been also provided to offer the user an integrated view of the whole EIDA, hiding the complexity of its internal structure. The service is open and able to be queried by anyone without the need of credentials or authentication. The QC Service is developed to cope with user requirements to query for relevant data only. The web service provides detailed information on the

Educating Next Generation Nuclear Criticality Safety Engineers at the Idaho National Laboratory

Energy Technology Data Exchange (ETDEWEB)

J. D. Bess; J. B. Briggs; A. S. Garcia

2011-09-01

One of the challenges in educating our next generation of nuclear safety engineers is the limitation of opportunities to receive significant experience or hands-on training prior to graduation. Such training is generally restricted to on-the-job-training before this new engineering workforce can adequately provide assessment of nuclear systems and establish safety guidelines. Participation in the International Criticality Safety Benchmark Evaluation Project (ICSBEP) and the International Reactor Physics Experiment Evaluation Project (IRPhEP) can provide students and young professionals the opportunity to gain experience and enhance critical engineering skills. The ICSBEP and IRPhEP publish annual handbooks that contain evaluations of experiments along with summarized experimental data and peer-reviewed benchmark specifications to support the validation of neutronics codes, nuclear cross-section data, and the validation of reactor designs. Participation in the benchmark process not only benefits those who use these Handbooks within the international community, but provides the individual with opportunities for professional development, networking with an international community of experts, and valuable experience to be used in future employment. Traditionally students have participated in benchmarking activities via internships at national laboratories, universities, or companies involved with the ICSBEP and IRPhEP programs. Additional programs have been developed to facilitate the nuclear education of students while participating in the benchmark projects. These programs include coordination with the Center for Space Nuclear Research (CSNR) Next Degree Program, the Collaboration with the Department of Energy Idaho Operations Office to train nuclear and criticality safety engineers, and student evaluations as the basis for their Master's thesis in nuclear engineering.

Educating Next Generation Nuclear Criticality Safety Engineers at the Idaho National Laboratory

International Nuclear Information System (INIS)

Bess, J.D.; Briggs, J.B.; Garcia, A.S.

2011-01-01

One of the challenges in educating our next generation of nuclear safety engineers is the limitation of opportunities to receive significant experience or hands-on training prior to graduation. Such training is generally restricted to on-the-job-training before this new engineering workforce can adequately provide assessment of nuclear systems and establish safety guidelines. Participation in the International Criticality Safety Benchmark Evaluation Project (ICSBEP) and the International Reactor Physics Experiment Evaluation Project (IRPhEP) can provide students and young professionals the opportunity to gain experience and enhance critical engineering skills. The ICSBEP and IRPhEP publish annual handbooks that contain evaluations of experiments along with summarized experimental data and peer-reviewed benchmark specifications to support the validation of neutronics codes, nuclear cross-section data, and the validation of reactor designs. Participation in the benchmark process not only benefits those who use these Handbooks within the international community, but provides the individual with opportunities for professional development, networking with an international community of experts, and valuable experience to be used in future employment. Traditionally students have participated in benchmarking activities via internships at national laboratories, universities, or companies involved with the ICSBEP and IRPhEP programs. Additional programs have been developed to facilitate the nuclear education of students while participating in the benchmark projects. These programs include coordination with the Center for Space Nuclear Research (CSNR) Next Degree Program, the Collaboration with the Department of Energy Idaho Operations Office to train nuclear and criticality safety engineers, and student evaluations as the basis for their Master's thesis in nuclear engineering.

IPv6: The Next Generation Internet Protocol

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 3. IPv6: The Next Generation Internet Protocol - IPv4 and its Shortcomings. Harsha Srinath. General Article Volume 8 Issue 3 March 2003 pp 33-41. Fulltext. Click here to view fulltext PDF. Permanent link:

IPv6: The Next Generation Internet Protocol

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 4. IPv6: The Next Generation Internet Protocol - New Features in IPv6. Harsha Srinath. General Article Volume 8 Issue 4 April 2003 pp 8-16. Fulltext. Click here to view fulltext PDF. Permanent link:

Development of the Next Generation Gas Trap for the Space Station Internal Thermal Control System

Science.gov (United States)

Leimkuehler, Thomas O.; Spelbring, Chris; Reeves, Daniel R.; Holt, James M.

2003-01-01

The current dual-membrane gas trap is designed to remove non-condensed gases (NCG) from the Internal Thermal Control System (ITCS) coolant on board the International Space Station (ISS). To date it has successfully served its purpose of preventing depriming, overspeed, and shutdown of the ITCS pump. However, contamination in the ITCS coolant has adversely affected the gas venting rate and lifetime of the gas trap, warranting a development effort for a next-generation gas trap. Design goals are to meet or exceed the current requirements to (1) include greater operating ranges and conditions, (2) eliminate reliance on the current hydrophilic tube fabrication process, and (3) increase operational life and tolerance to particulate and microbial growth fouling. In addition, the next generation gas trap will essentially be a 'dropin" design such that no modifications to the ITCS pump package assembly (PPA) will be required, and the implementation of the new design will not affect changes to the ITCS operational conditions, interfaces, or software. This paper will present the initial membrane module design and development work which has included (1) a trade study among several conceptual designs, (2) performance modeling of a hydrophobic-only design, and (3) small-scale development test data for the hydrophobic-only design. Testing has shown that the hydrophobic-only design is capable of performing even better than the current dual-membrane design for both steady-state gas removal and gas slug removal.

Next-Generation Sequencing for Binary Protein-Protein Interactions

Directory of Open Access Journals (Sweden)

Bernhard eSuter

2015-12-01

Full Text Available The yeast two-hybrid (Y2H system exploits host cell genetics in order to display binary protein-protein interactions (PPIs via defined and selectable phenotypes. Numerous improvements have been made to this method, adapting the screening principle for diverse applications, including drug discovery and the scale-up for proteome wide interaction screens in human and other organisms. Here we discuss a systematic workflow and analysis scheme for screening data generated by Y2H and related assays that includes high-throughput selection procedures, readout of comprehensive results via next-generation sequencing (NGS, and the interpretation of interaction data via quantitative statistics. The novel assays and tools will serve the broader scientific community to harness the power of NGS technology to address PPI networks in health and disease. We discuss examples of how this next-generation platform can be applied to address specific questions in diverse fields of biology and medicine.

High-performance ferroelectric and magnetoresistive materials for next-generation thermal detector arrays

Science.gov (United States)

Todd, Michael A.; Donohue, Paul P.; Watton, Rex; Williams, Dennis J.; Anthony, Carl J.; Blamire, Mark G.

2002-12-01

This paper discusses the potential thermal imaging performance achievable from thermal detector arrays and concludes that the current generation of thin-film ferroelectric and resistance bolometer based detector arrays are limited by the detector materials used. It is proposed that the next generation of large uncooled focal plane arrays will need to look towards higher performance detector materials - particularly if they aim to approach the fundamental performance limits and compete with cooled photon detector arrays. Two examples of bolometer thin-film materials are described that achieve high performance from operating around phase transitions. The material Lead Scandium Tantalate (PST) has a paraelectric-to-ferroelectric phase transition around room temperature and is used with an applied field in the dielectric bolometer mode for thermal imaging. PST films grown by sputtering and liquid-source CVD have shown merit figures for thermal imaging a factor of 2 to 3 times higher than PZT-based pyroelectric thin films. The material Lanthanum Calcium Manganite (LCMO) has a paramagnetic to ferromagnetic phase transition around -20oC. This paper describes recent measurements of TCR and 1/f noise in pulsed laser-deposited LCMO films on Neodymium Gallate substrates. These results show that LCMO not only has high TCR's - up to 30%/K - but also low 1/f excess noise, with bolometer merit figures at least an order of magnitude higher than Vanadium Oxide, making it ideal for the next generation of microbolometer arrays. These high performance properties come at the expense of processing complexities and novel device designs will need to be introduced to realize the potential of these materials in the next generation of thermal detectors.

A Next Generation Light Source Facility at LBNL

International Nuclear Information System (INIS)

Corlett, J.N.; Austin, B.; Baptiste, K.M.; Byrd, J.M.; Denes, P.; Donahue, R.; Doolittle, L.; Falcone, R.W.; Filippetto, D.; Fournier, S.; Li, D.; Padmore, H.A.; Papadopoulos, C.; Pappas, C.; Penn, G.; Placidi, M.; Prestemon, S.; Prosnitz, D.; Qiang, J.; Ratti, A.; Reinsch, M.; Sannibale, F.; Schlueter, R.; Schoenlein, R.W.; Staples, J.W.; Vecchione, T.; Venturini, M.; Wells, R.; Wilcox, R.; Wurtele, J.; Charman, A.; Kur, E.; Zholents, A.A.

2011-01-01

The Next Generation Light Source (NGLS) is a design concept, under development at LBNL, for a multibeamline soft x-ray FEL array powered by a ∼2 GeV superconducting linear accelerator, operating with a 1 MHz bunch repetition rate. The CW superconducting linear accelerator is supplied by a high-brightness, high-repetition-rate photocathode electron gun. Electron bunches are distributed from the linac to the array of independently configurable FEL beamlines with nominal bunch rates up to 100 kHz in each FEL, and with even pulse spacing. Individual FELs may be configured for EEHG, HGHG, SASE, or oscillator mode of operation, and will produce high peak and average brightness x-rays with a flexible pulse format, with pulse durations ranging from sub-femtoseconds to hundreds of femtoseconds.

Coupled Qubits for Next Generation Quantum Annealing: Improving Coherence

Science.gov (United States)

Weber, Steven; Samach, Gabriel; Hover, David; Rosenberg, Danna; Yoder, Jonilyn; Kim, David K.; Kerman, Andrew; Oliver, William D.

Quantum annealing is an optimization technique which potentially leverages quantum tunneling to enhance computational performance. Existing quantum annealers use superconducting flux qubits with short coherence times, limited primarily by the use of large persistent currents. Here, we examine an alternative approach, using flux qubits with smaller persistent currents and longer coherence times. We demonstrate tunable coupling, a basic building-block for quantum annealing, between two such qubits. Furthermore, we characterize qubit coherence as a function of coupler setting and investigate the effect of flux noise in the coupler loop on qubit coherence. Our results provide insight into the available design space for next-generation quantum annealers with improved coherence. This research was funded by the Office of the Director of National Intelligence (ODNI), Intelligence Advanced Research Projects Activity (IARPA) and by the Assistant Secretary of Defense for Research & Engineering under Air Force Contract No. FA8721-05-C-0002. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of ODNI, IARPA, or the US Government.

Thermal hydrodynamic modeling and simulation of hot-gas duct for next-generation nuclear reactor

Energy Technology Data Exchange (ETDEWEB)

Lee, Injun [School of Mechanical Engineering, Yeungnam University, Gyeongsan 712-749 (Korea, Republic of); Hong, Sungdeok; Kim, Chansoo [Korea Atomic Energy Research Institute, Daejeon 305-353 (Korea, Republic of); Bai, Cheolho; Hong, Sungyull [School of Mechanical Engineering, Yeungnam University, Gyeongsan 712-749 (Korea, Republic of); Shim, Jaesool, E-mail: jshim@ynu.ac.kr [School of Mechanical Engineering, Yeungnam University, Gyeongsan 712-749 (Korea, Republic of)

2016-12-15

Highlights: • Thermal hydrodynamic nonlinear model is presented to examine a hot gas duct (HGD) used in a fourth-generation nuclear power reactor. • Experiments and simulation were compared to validate the nonlinear porous model. • Natural convection and radiation are considered to study the effect on the surface temperature of the HGD. • Local Nusselt number is obtained for the optimum design of a possible next-generation HGD. - Abstract: A very high-temperature gas-cooled reactor (VHTR) is a fourth-generation nuclear power reactor that requires an intermediate loop that consists of a hot-gas duct (HGD), an intermediate heat exchanger (IHX), and a process heat exchanger for massive hydrogen production. In this study, a mathematical model and simulation were developed for the HGD in a small-scale nitrogen gas loop that was designed and manufactured by the Korea Atomic Energy Research Institute. These were used to investigate the effect of various important factors on the surface of the HGD. In the modeling, a porous model was considered for a Kaowool insulator inside the HGD. The natural convection and radiation are included in the model. For validation, the modeled external surface temperatures are compared with experimental results obtained while changing the inlet temperatures of the nitrogen working fluid. The simulation results show very good agreement with the experiments. The external surface temperatures of the HGD are obtained with respect to the porosity of insulator, emissivity of radiation, and pressure of the working fluid. The local Nusselt number is also obtained for the optimum design of a possible next-generation HGD.

NIRS report of investigations for the development of the next generation PET apparatus. FY 2002

International Nuclear Information System (INIS)

2003-03-01

The present status of studies conducted by representative technology fields for the development of the next generation PET apparatus, and the summary of opinions given by investigators of nuclear medicine are reported. The former involves chapters of: Summary of representative technologies for the development of the next generation PET apparatus; Count rate analysis of PET apparatuses for the whole body and small animals by PET simulator; Scintillator; DOI (depth of interaction) detector-evaluation of the detector with 256-ch fluorescence polarization-photomultiplier tubes (FP-PMT) trial apparatus etc; Examination of multi-slice DOI-MR compatible detector for PET; Development of application specific integrated circuit (ASIC) for processing the front-end signals; Detector simulation; Circuit for processing PET detector signals; Signal processing-coincidence circuit; Data collection system; Signal processing technology for the next generation PET; Reconstruction of statistical PET image using DOI signals; Monte Carlo simulation and Unique directions-PET for infants and for the whole body autonomic nervous systems and mental activity; and Actual design and evaluation of image reconstruction by statistical means. Opinions are: Progress of clinical PET apparatus; Desirable PET drugs and apparatuses; From clinical practice for the development of the next generation PET apparatus; From clinical psychiatric studies for the development; From application of drug development and basic researches; From brain PET practice; From clinical PET practice; and The role of National Institute of Radiological Sciences (NIRS) in PET development. Also involved is the publication list. (N.I.)

NOAA Next Generation Radar (NEXRAD) Level 3 Products

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level 3 weather radar products collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska,...

BG7: A New Approach for Bacterial Genome Annotation Designed for Next Generation Sequencing Data

Science.gov (United States)

Pareja-Tobes, Pablo; Manrique, Marina; Pareja-Tobes, Eduardo; Pareja, Eduardo; Tobes, Raquel

2012-01-01

BG7 is a new system for de novo bacterial, archaeal and viral genome annotation based on a new approach specifically designed for annotating genomes sequenced with next generation sequencing technologies. The system is versatile and able to annotate genes even in the step of preliminary assembly of the genome. It is especially efficient detecting unexpected genes horizontally acquired from bacterial or archaeal distant genomes, phages, plasmids, and mobile elements. From the initial phases of the gene annotation process, BG7 exploits the massive availability of annotated protein sequences in databases. BG7 predicts ORFs and infers their function based on protein similarity with a wide set of reference proteins, integrating ORF prediction and functional annotation phases in just one step. BG7 is especially tolerant to sequencing errors in start and stop codons, to frameshifts, and to assembly or scaffolding errors. The system is also tolerant to the high level of gene fragmentation which is frequently found in not fully assembled genomes. BG7 current version – which is developed in Java, takes advantage of Amazon Web Services (AWS) cloud computing features, but it can also be run locally in any operating system. BG7 is a fast, automated and scalable system that can cope with the challenge of analyzing the huge amount of genomes that are being sequenced with NGS technologies. Its capabilities and efficiency were demonstrated in the 2011 EHEC Germany outbreak in which BG7 was used to get the first annotations right the next day after the first entero-hemorrhagic E. coli genome sequences were made publicly available. The suitability of BG7 for genome annotation has been proved for Illumina, 454, Ion Torrent, and PacBio sequencing technologies. Besides, thanks to its plasticity, our system could be very easily adapted to work with new technologies in the future. PMID:23185310

BG7: a new approach for bacterial genome annotation designed for next generation sequencing data.

Directory of Open Access Journals (Sweden)

Pablo Pareja-Tobes

Full Text Available BG7 is a new system for de novo bacterial, archaeal and viral genome annotation based on a new approach specifically designed for annotating genomes sequenced with next generation sequencing technologies. The system is versatile and able to annotate genes even in the step of preliminary assembly of the genome. It is especially efficient detecting unexpected genes horizontally acquired from bacterial or archaeal distant genomes, phages, plasmids, and mobile elements. From the initial phases of the gene annotation process, BG7 exploits the massive availability of annotated protein sequences in databases. BG7 predicts ORFs and infers their function based on protein similarity with a wide set of reference proteins, integrating ORF prediction and functional annotation phases in just one step. BG7 is especially tolerant to sequencing errors in start and stop codons, to frameshifts, and to assembly or scaffolding errors. The system is also tolerant to the high level of gene fragmentation which is frequently found in not fully assembled genomes. BG7 current version - which is developed in Java, takes advantage of Amazon Web Services (AWS cloud computing features, but it can also be run locally in any operating system. BG7 is a fast, automated and scalable system that can cope with the challenge of analyzing the huge amount of genomes that are being sequenced with NGS technologies. Its capabilities and efficiency were demonstrated in the 2011 EHEC Germany outbreak in which BG7 was used to get the first annotations right the next day after the first entero-hemorrhagic E. coli genome sequences were made publicly available. The suitability of BG7 for genome annotation has been proved for Illumina, 454, Ion Torrent, and PacBio sequencing technologies. Besides, thanks to its plasticity, our system could be very easily adapted to work with new technologies in the future.

Next Generation Nuclear Plant Methods Technical Program Plan

Energy Technology Data Exchange (ETDEWEB)

Richard R. Schultz; Abderrafi M. Ougouag; David W. Nigg; Hans D. Gougar; Richard W. Johnson; William K. Terry; Chang H. Oh; Donald W. McEligot; Gary W. Johnsen; Glenn E. McCreery; Woo Y. Yoon; James W. Sterbentz; J. Steve Herring; Temitope A. Taiwo; Thomas Y. C. Wei; William D. Pointer; Won S. Yang; Michael T. Farmer; Hussein S. Khalil; Madeline A. Feltus

2010-12-01

One of the great challenges of designing and licensing the Very High Temperature Reactor (VHTR) is to confirm that the intended VHTR analysis tools can be used confidently to make decisions and to assure all that the reactor systems are safe and meet the performance objectives of the Generation IV Program. The research and development (R&D) projects defined in the Next Generation Nuclear Plant (NGNP) Design Methods Development and Validation Program will ensure that the tools used to perform the required calculations and analyses can be trusted. The Methods R&D tasks are designed to ensure that the calculational envelope of the tools used to analyze the VHTR reactor systems encompasses, or is larger than, the operational and transient envelope of the VHTR itself. The Methods R&D focuses on the development of tools to assess the neutronic and thermal fluid behavior of the plant. The fuel behavior and fission product transport models are discussed in the Advanced Gas Reactor (AGR) program plan. Various stress analysis and mechanical design tools will also need to be developed and validated and will ultimately also be included in the Methods R&D Program Plan. The calculational envelope of the neutronics and thermal-fluids software tools intended to be used on the NGNP is defined by the scenarios and phenomena that these tools can calculate with confidence. The software tools can only be used confidently when the results they produce have been shown to be in reasonable agreement with first-principle results, thought-problems, and data that describe the “highly ranked” phenomena inherent in all operational conditions and important accident scenarios for the VHTR.

Next Generation PanDA Pilot for ATLAS and Other Experiments

CERN Document Server

Nilsson, P; The ATLAS collaboration; Caballero Bejar, J; De, K; Hover, J; Love, P; Maeno, T; Medrano Llamas, R; Walker, R; Wenaus, T

2013-01-01

The Production and Distributed Analysis system (PanDA) has been in use in the ATLAS Experiment since 2005. It uses a sophisticated pilot system to execute submitted jobs on the worker nodes. While originally designed for ATLAS, the PanDA Pilot has recently been refactored to facilitate use outside of ATLAS. Experiments are now handled as plug-ins such that a new PanDA Pilot user only has to implement a set of prototyped methods in the plug-in classes, and provide a script that configures and runs the experiment specific payload. We will give an overview of the Next Generation PanDA Pilot system and will present major features and recent improvements including live user payload debugging, data access via the Federated XRootD system, stage-out to alternative storage elements, support for the new ATLAS DDM system (Rucio), and an improved integration with glExec, as well as a description of the experiment specific plug-in classes. The performance of the pilot system in processing LHC data on the OSG, LCG and Nord...

Next Generation PanDA Pilot for ATLAS and Other Experiments

CERN Document Server

Nilsson, P; The ATLAS collaboration; Caballero Bejar, J; De, K; Hover, J; Love, P; Maeno, T; Medrano Llamas, R; Walker, R; Wenaus, T

2014-01-01

The Production and Distributed Analysis system (PanDA) has been in use in the ATLAS Experiment since 2005. It uses a sophisticated pilot system to execute submitted jobs on the worker nodes. While originally designed for ATLAS, the PanDA Pilot has recently been refactored to facilitate use outside of ATLAS. Experiments are now handled as plug-ins such that a new PanDA Pilot user only has to implement a set of prototyped methods in the plug-in classes, and provide a script that configures and runs the experiment specific payload. We will give an overview of the Next Generation PanDA Pilot system and will present major features and recent improvements including live user payload debugging, data access via the Federated XRootD system, stage-out to alternative storage elements, support for the new ATLAS DDM system (Rucio), and an improved integration with glExec, as well as a description of the experiment specific plug-in classes. The performance of the pilot system in processing LHC data on the OSG, LCG and Nord...

Development of digital plant protection system for Korean Next Generation Reactor

Energy Technology Data Exchange (ETDEWEB)

Park, Suk-Joon [NSSS Engineering and Development Division, Korea Power Engineering Company, Taejon (Korea, Republic of)

1998-10-01

A Digital Plant Protection System (DPPS) for Korean Next Generation Reactor (KNGR) is being developed using the Programmable Logic Controller (PLC) technology. For the design verification, the development of the DPPS prototype is progressing at this time. The prototype hardware equipment is installed and software coding is started. DPPS software is being coded by strict software V and V activities and function block language that uses simple graphical symbols. By adopting the PLC technology, the design of DPPS is possible to take full advantages in areas such as automatic testing, simplified calibration, improved isolation between redundant channels, reduced internal and external wiring and increased plant availability. (author) 8 refs, 4 figs, 3 tabs

Benchmark problem suite for reactor physics study of LWR next generation fuels

International Nuclear Information System (INIS)

Yamamoto, Akio; Ikehara, Tadashi; Ito, Takuya; Saji, Etsuro

2002-01-01

This paper proposes a benchmark problem suite for studying the physics of next-generation fuels of light water reactors. The target discharge burnup of the next-generation fuel was set to 70 GWd/t considering the increasing trend in discharge burnup of light water reactor fuels. The UO 2 and MOX fuels are included in the benchmark specifications. The benchmark problem consists of three different geometries: fuel pin cell, PWR fuel assembly and BWR fuel assembly. In the pin cell problem, detailed nuclear characteristics such as burnup dependence of nuclide-wise reactivity were included in the required calculation results to facilitate the study of reactor physics. In the assembly benchmark problems, important parameters for in-core fuel management such as local peaking factors and reactivity coefficients were included in the required results. The benchmark problems provide comprehensive test problems for next-generation light water reactor fuels with extended high burnup. Furthermore, since the pin cell, the PWR assembly and the BWR assembly problems are independent, analyses of the entire benchmark suite is not necessary: e.g., the set of pin cell and PWR fuel assembly problems will be suitable for those in charge of PWR in-core fuel management, and the set of pin cell and BWR fuel assembly problems for those in charge of BWR in-core fuel management. (author)

Examination of concept of next generation computer. Progress report 1999

Energy Technology Data Exchange (ETDEWEB)

Higuchi, Kenji; Hasegawa, Yukihiro; Hirayama, Toshio

2000-12-01

The Center for Promotion of Computational Science and Engineering has conducted R and D works on the technology of parallel processing and has started the examination of the next generation computer in 1999. This report describes the behavior analyses of quantum calculation codes. It also describes the consideration for the analyses and examination results for the method to reduce cash misses. Furthermore, it describes a performance simulator that is being developed to quantitatively examine the concept of the next generation computer. (author)

Next-Generation Pathology.

Science.gov (United States)

Caie, Peter D; Harrison, David J

2016-01-01

The field of pathology is rapidly transforming from a semiquantitative and empirical science toward a big data discipline. Large data sets from across multiple omics fields may now be extracted from a patient's tissue sample. Tissue is, however, complex, heterogeneous, and prone to artifact. A reductionist view of tissue and disease progression, which does not take this complexity into account, may lead to single biomarkers failing in clinical trials. The integration of standardized multi-omics big data and the retention of valuable information on spatial heterogeneity are imperative to model complex disease mechanisms. Mathematical modeling through systems pathology approaches is the ideal medium to distill the significant information from these large, multi-parametric, and hierarchical data sets. Systems pathology may also predict the dynamical response of disease progression or response to therapy regimens from a static tissue sample. Next-generation pathology will incorporate big data with systems medicine in order to personalize clinical practice for both prognostic and predictive patient care.

Potential of OFDM for next generation optical access

Science.gov (United States)

Fritzsche, Daniel; Weis, Erik; Breuer, Dirk

2011-01-01

This paper shows the requirements for next generation optical access (NGOA) networks and analyzes the potential of OFDM (orthogonal frequency division multiplexing) for the use in such network scenarios. First, we show the motivation for NGOA systems based on the future requirements on FTTH access systems and list the advantages of OFDM in such scenarios. In the next part, the basics of OFDM and different methods to generate and detect optical OFDM signals are explained and analyzed. At the transmitter side the options include intensity modulation and the more advanced field modulation of the optical OFDM signal. At the receiver there is the choice between direct detection and coherent detection. As the result of this discussion we show our vision of the future use of OFDM in optical access networks.

Design of a High Density SNP Genotyping Assay in the Pig Using SNPs Identified and Characterized by Next Generation Sequencing Technology

Science.gov (United States)

Ramos, Antonio M.; Crooijmans, Richard P. M. A.; Affara, Nabeel A.; Amaral, Andreia J.; Archibald, Alan L.; Beever, Jonathan E.; Bendixen, Christian; Churcher, Carol; Clark, Richard; Dehais, Patrick; Hansen, Mark S.; Hedegaard, Jakob; Hu, Zhi-Liang; Kerstens, Hindrik H.; Law, Andy S.; Megens, Hendrik-Jan; Milan, Denis; Nonneman, Danny J.; Rohrer, Gary A.; Rothschild, Max F.; Smith, Tim P. L.; Schnabel, Robert D.; Van Tassell, Curt P.; Taylor, Jeremy F.; Wiedmann, Ralph T.; Schook, Lawrence B.; Groenen, Martien A. M.

2009-01-01

Background The dissection of complex traits of economic importance to the pig industry requires the availability of a significant number of genetic markers, such as single nucleotide polymorphisms (SNPs). This study was conducted to discover several hundreds of thousands of porcine SNPs using next generation sequencing technologies and use these SNPs, as well as others from different public sources, to design a high-density SNP genotyping assay. Methodology/Principal Findings A total of 19 reduced representation libraries derived from four swine breeds (Duroc, Landrace, Large White, Pietrain) and a Wild Boar population and three restriction enzymes (AluI, HaeIII and MspI) were sequenced using Illumina's Genome Analyzer (GA). The SNP discovery effort resulted in the de novo identification of over 372K SNPs. More than 549K SNPs were used to design the Illumina Porcine 60K+SNP iSelect Beadchip, now commercially available as the PorcineSNP60. A total of 64,232 SNPs were included on the Beadchip. Results from genotyping the 158 individuals used for sequencing showed a high overall SNP call rate (97.5%). Of the 62,621 loci that could be reliably scored, 58,994 were polymorphic yielding a SNP conversion success rate of 94%. The average minor allele frequency (MAF) for all scorable SNPs was 0.274. Conclusions/Significance Overall, the results of this study indicate the utility of using next generation sequencing technologies to identify large numbers of reliable SNPs. In addition, the validation of the PorcineSNP60 Beadchip demonstrated that the assay is an excellent tool that will likely be used in a variety of future studies in pigs. PMID:19654876

Next generation information systems

Energy Technology Data Exchange (ETDEWEB)

Limback, Nathan P [Los Alamos National Laboratory; Medina, Melanie A [Los Alamos National Laboratory; Silva, Michelle E [Los Alamos National Laboratory

2010-01-01

The Information Systems Analysis and Development (ISAD) Team of the Safeguards Systems Group at Los Alamos National Laboratory (LANL) has been developing web based information and knowledge management systems for sixteen years. Our vision is to rapidly and cost effectively provide knowledge management solutions in the form of interactive information systems that help customers organize, archive, post and retrieve nonproliferation and safeguards knowledge and information vital to their success. The team has developed several comprehensive information systems that assist users in the betterment and growth of their organizations and programs. Through our information systems, users are able to streamline operations, increase productivity, and share and access information from diverse geographic locations. The ISAD team is also producing interactive visual models. Interactive visual models provide many benefits to customers beyond the scope of traditional full-scale modeling. We have the ability to simulate a vision that a customer may propose, without the time constraints of traditional engineering modeling tools. Our interactive visual models can be used to access specialized training areas, controlled areas, and highly radioactive areas, as well as review site-specific training for complex facilities, and asset management. Like the information systems that the ISAD team develops, these models can be shared and accessed from any location with access to the internet. The purpose of this paper is to elaborate on the capabilities of information systems and interactive visual models as well as consider the possibility of combining the two capabilities to provide the next generation of infonnation systems. The collection, processing, and integration of data in new ways can contribute to the security of the nation by providing indicators and information for timely action to decrease the traditional and new nuclear threats. Modeling and simulation tied to comprehensive

Molecular Diagnostics in Pathology: Time for a Next-Generation Pathologist?

Science.gov (United States)

Fassan, Matteo

2018-03-01

- Comprehensive molecular investigations of mainstream carcinogenic processes have led to the use of effective molecular targeted agents in most cases of solid tumors in clinical settings. - To update readers regarding the evolving role of the pathologist in the therapeutic decision-making process and the introduction of next-generation technologies into pathology practice. - Current literature on the topic, primarily sourced from the PubMed (National Center for Biotechnology Information, Bethesda, Maryland) database, were reviewed. - Adequate evaluation of cytologic-based and tissue-based predictive diagnostic biomarkers largely depends on both proper pathologic characterization and customized processing of biospecimens. Moreover, increased requests for molecular testing have paralleled the recent, sharp decrease in tumor material to be analyzed-material that currently comprises cytology specimens or, at minimum, small biopsies in most cases of metastatic/advanced disease. Traditional diagnostic pathology has been completely revolutionized by the introduction of next-generation technologies, which provide multigene, targeted mutational profiling, even in the most complex of clinical cases. Combining traditional and molecular knowledge, pathologists integrate the morphological, clinical, and molecular dimensions of a disease, leading to a proper diagnosis and, therefore, the most-appropriate tailored therapy.

Data-Driven Handover Optimization in Next Generation Mobile Communication Networks

Directory of Open Access Journals (Sweden)

Po-Chiang Lin

2016-01-01

Full Text Available Network densification is regarded as one of the important ingredients to increase capacity for next generation mobile communication networks. However, it also leads to mobility problems since users are more likely to hand over to another cell in dense or even ultradense mobile communication networks. Therefore, supporting seamless and robust connectivity through such networks becomes a very important issue. In this paper, we investigate handover (HO optimization in next generation mobile communication networks. We propose a data-driven handover optimization (DHO approach, which aims to mitigate mobility problems including too-late HO, too-early HO, HO to wrong cell, ping-pong HO, and unnecessary HO. The key performance indicator (KPI is defined as the weighted average of the ratios of these mobility problems. The DHO approach collects data from the mobile communication measurement results and provides a model to estimate the relationship between the KPI and features from the collected dataset. Based on the model, the handover parameters, including the handover margin and time-to-trigger, are optimized to minimize the KPI. Simulation results show that the proposed DHO approach could effectively mitigate mobility problems.

THE TRAINING OF NEXT GENERATION DATA SCIENTISTS IN BIOMEDICINE.

Science.gov (United States)

Garmire, Lana X; Gliske, Stephen; Nguyen, Quynh C; Chen, Jonathan H; Nemati, Shamim; VAN Horn, John D; Moore, Jason H; Shreffler, Carol; Dunn, Michelle

2017-01-01

With the booming of new technologies, biomedical science has transformed into digitalized, data intensive science. Massive amount of data need to be analyzed and interpreted, demand a complete pipeline to train next generation data scientists. To meet this need, the transinstitutional Big Data to Knowledge (BD2K) Initiative has been implemented since 2014, complementing other NIH institutional efforts. In this report, we give an overview the BD2K K01 mentored scientist career awards, which have demonstrated early success. We address the specific trainings needed in representative data science areas, in order to make the next generation of data scientists in biomedicine.

A Survey on Next-generation Power Grid Data Architecture

Energy Technology Data Exchange (ETDEWEB)

You, Shutang [University of Tennessee, Knoxville (UTK); Zhu, Dr. Lin [University of Tennessee (UT); Liu, Yong [ORNL; Liu, Yilu [ORNL; Shankar, Mallikarjun (Arjun) [ORNL; Robertson, Russell [Grid Protection Alliance; King Jr, Thomas J [ORNL

2015-01-01

The operation and control of power grids will increasingly rely on data. A high-speed, reliable, flexible and secure data architecture is the prerequisite of the next-generation power grid. This paper summarizes the challenges in collecting and utilizing power grid data, and then provides reference data architecture for future power grids. Based on the data architecture deployment, related research on data architecture is reviewed and summarized in several categories including data measurement/actuation, data transmission, data service layer, data utilization, as well as two cross-cutting issues, interoperability and cyber security. Research gaps and future work are also presented.

Conceptual design of once-through helical steam generator for SMART

Energy Technology Data Exchange (ETDEWEB)

Kim, Yong Wan; Kim, J. I.; Kim, J. H. [Korea Atomic Energy Research Institute, Taejon (Korea)

1999-12-01

Conceptual design of once-through helical steam generator for the integral reactor SMART is developed. The once-through helical steam generator requires quite different design concepts from the steam generators used in loop type commercial reactors. In this study the design requirements satisfying the operating conditions of the steam generator are derived, and the arrangements and the dimensions of the major parts are determined. By describing the design procedure, the cost of redesign and the costs of developments of similar new steam generators are minimized. The three dimensional models developed make it possible to preview the interferences of the steam generator components and to minimize the possibility of significant design changes in the next design stage by the preliminary strength analysis of the major parts. A methodology for evaluation of flow induced vibration of steam generator tubes has been developed and a preliminary flow induced vibration analysis has been performed. 24 refs., 54 figs., 9 tabs. (Author)

The Next Generation Transit Survey (NGTS)

Science.gov (United States)

Wheatley, Peter J.; West, Richard G.; Goad, Michael R.; Jenkins, James S.; Pollacco, Don L.; Queloz, Didier; Rauer, Heike; Udry, Stéphane; Watson, Christopher A.; Chazelas, Bruno; Eigmüller, Philipp; Lambert, Gregory; Genolet, Ludovic; McCormac, James; Walker, Simon; Armstrong, David J.; Bayliss, Daniel; Bento, Joao; Bouchy, François; Burleigh, Matthew R.; Cabrera, Juan; Casewell, Sarah L.; Chaushev, Alexander; Chote, Paul; Csizmadia, Szilárd; Erikson, Anders; Faedi, Francesca; Foxell, Emma; Gänsicke, Boris T.; Gillen, Edward; Grange, Andrew; Günther, Maximilian N.; Hodgkin, Simon T.; Jackman, James; Jordán, Andrés; Louden, Tom; Metrailler, Lionel; Moyano, Maximiliano; Nielsen, Louise D.; Osborn, Hugh P.; Poppenhaeger, Katja; Raddi, Roberto; Raynard, Liam; Smith, Alexis M. S.; Soto, Maritza; Titz-Weider, Ruth

2018-04-01

We describe the Next Generation Transit Survey (NGTS), which is a ground-based project searching for transiting exoplanets orbiting bright stars. NGTS builds on the legacy of previous surveys, most notably WASP, and is designed to achieve higher photometric precision and hence find smaller planets than have previously been detected from the ground. It also operates in red light, maximizing sensitivity to late K and early M dwarf stars. The survey specifications call for photometric precision of 0.1 per cent in red light over an instantaneous field of view of 100 deg2, enabling the detection of Neptune-sized exoplanets around Sun-like stars and super-Earths around M dwarfs. The survey is carried out with a purpose-built facility at Cerro Paranal, Chile, which is the premier site of the European Southern Observatory (ESO). An array of twelve 20 cm f/2.8 telescopes fitted with back-illuminated deep-depletion CCD cameras is used to survey fields intensively at intermediate Galactic latitudes. The instrument is also ideally suited to ground-based photometric follow-up of exoplanet candidates from space telescopes such as TESS, Gaia and PLATO. We present observations that combine precise autoguiding and the superb observing conditions at Paranal to provide routine photometric precision of 0.1 per cent in 1 h for stars with I-band magnitudes brighter than 13. We describe the instrument and data analysis methods as well as the status of the survey, which achieved first light in 2015 and began full-survey operations in 2016. NGTS data will be made publicly available through the ESO archive.

Radio resource management for next generation mobile communication systems

DEFF Research Database (Denmark)

Wang, Hua

The key feature of next generation (4G) mobile communication system is the ability to deliver a variety of multimedia services with different Quality-of-Service (QoS) requirements. Compared to the third generation (3G) mobile communication systems, 4G mobile communication system introduces several...

Next Generation Melter Optioneering Study - Interim Report

International Nuclear Information System (INIS)

Gray, M.F.; Calmus, R.B.; Ramsey, G.; Lomax, J.; Allen, H.

2010-01-01

The next generation melter (NOM) development program includes a down selection process to aid in determining the recommended vitrification technology to implement into the WTP at the first melter change-out which is scheduled for 2025. This optioneering study presents a structured value engineering process to establish and assess evaluation criteria that will be incorporated into the down selection process. This process establishes an evaluation framework that will be used progressively throughout the NGM program, and as such this interim report will be updated on a regular basis. The workshop objectives were achieved. In particular: (1) Consensus was reached with stakeholders and technology providers represented at the workshop regarding the need for a decision making process and the application of the D 2 0 process to NGM option evaluation. (2) A framework was established for applying the decision making process to technology development and evaluation between 2010 and 2013. (3) The criteria for the initial evaluation in 2011 were refined and agreed with stakeholders and technology providers. (4) The technology providers have the guidance required to produce data/information to support the next phase of the evaluation process. In some cases it may be necessary to reflect the data/information requirements and overall approach to the evaluation of technology options against specific criteria within updated Statements of Work for 2010-2011. Access to the WTP engineering data has been identified as being very important for option development and evaluation due to the interface issues for the NGM and surrounding plant. WRPS efforts are ongoing to establish precisely data that is required and how to resolve this Issue. It is intended to apply a similarly structured decision making process to the development and evaluation of LAW NGM options.

The next generation safeguards initiative

International Nuclear Information System (INIS)

Tobey, William

2008-01-01

NGSI or the Next Generation Safeguards Initiative is designed to revitalize the U.S. safeguards technical base, as well as invest in human resources, and to mobilize our primary asset - the U.S. National Laboratories - as well as industry and academia to restore capabilities. While NGSI is a U.S. effort it is intended to serve as a catalyst for a much broader commitment to international safeguards in partnership with the IAEA and other countries. Initiatives over the last years include such as the Proliferation Security Initiative, UN Security Council Resolution 1540, the Global Initiative to Combat Nuclear Terrorism, and initiatives of the G-8 and NSG to discourage the spread of enrichment and reprocessing. NGSI augments this agenda by providing a means to strengthen the technical and political underpinnings of IAEA safeguards. Priorities and envisioned activities under NGSI are the following. (1) Cooperation with IAEA and others to promote universal adoption of safeguards agreements and the Additional Protocol including greater information sharing between member states and the IAEA, investigation of weaponization and procurement activities, and options to strengthen the state-level approach to safeguards. (2) NGSI anticipates the deployment of new types of reactors and fuel cycle facilities, as well as the need to use limited safeguards resources effectively and efficiently, especially in plants that pose the largest burden specifically complex, bulk-handling facilities. (3) NGSI will encourage a generational improvement in current safeguards technologies including improvement of precision and speed of nuclear measurements, performance of real-time process monitoring and surveillance in unattended mode, enabling in-field, pre-screening and analysis of nuclear and environmental samples, and collection, integration, analysis and archiving safeguards-relevant information from all available sources.(4) NGSI will address human capital management. Training and

The Nature of Science and the "Next Generation Science Standards": Analysis and Critique

Science.gov (United States)

McComas, William F.; Nouri, Noushin

2016-01-01

This paper provides a detailed analysis of the inclusion of aspects of nature of science (NOS) in the "Next Generation Science Standards" (NGSS). In this new standards document, NOS elements in eight categories are discussed in Appendix H along with illustrative statements (called exemplars). Many, but not all, of these exemplars are…

Control of Next Generation Aircraft and Wind Turbines

Science.gov (United States)

Frost, Susan

2010-01-01

The first part of this talk will describe some of the exciting new next generation aircraft that NASA is proposing for the future. These aircraft are being designed to reduce aircraft fuel consumption and environmental impact. Reducing the aircraft weight is one approach that will be used to achieve these goals. A new control framework will be presented that enables lighter, more flexible aircraft to maintain aircraft handling qualities, while preventing the aircraft from exceeding structural load limits. The second part of the talk will give an overview of utility-scale wind turbines and their control. Results of collaboration with Dr. Balas will be presented, including new theory to adaptively control the turbine in the presence of structural modes, with the focus on the application of this theory to a high-fidelity simulation of a wind turbine.

Precision medicine for cancer with next-generation functional diagnostics.

Science.gov (United States)

Friedman, Adam A; Letai, Anthony; Fisher, David E; Flaherty, Keith T

2015-12-01

Precision medicine is about matching the right drugs to the right patients. Although this approach is technology agnostic, in cancer there is a tendency to make precision medicine synonymous with genomics. However, genome-based cancer therapeutic matching is limited by incomplete biological understanding of the relationship between phenotype and cancer genotype. This limitation can be addressed by functional testing of live patient tumour cells exposed to potential therapies. Recently, several 'next-generation' functional diagnostic technologies have been reported, including novel methods for tumour manipulation, molecularly precise assays of tumour responses and device-based in situ approaches; these address the limitations of the older generation of chemosensitivity tests. The promise of these new technologies suggests a future diagnostic strategy that integrates functional testing with next-generation sequencing and immunoprofiling to precisely match combination therapies to individual cancer patients.

Nuclear the next generation. 34th Annual Canadian Nuclear Society conference and 37th CNS/CNA student conference

Energy Technology Data Exchange (ETDEWEB)

NONE

2013-07-01

The 34th Annual Canadian Nuclear Society Conference and 37th CNS/CNA Student Conference was held in Toronto, Ontario, Canada on June 10-13, 2013. With the theme of the conference, 'Nuclear the Next Generation{sup ,} the conference actively engaged 400 participants in the many facets of this well-rum event. The conference combined excellent plenary speakers, a full set of technical papers, challenging student poster competitions, and interesting exhibits. The plenary session focussed on the themes: 'Nuclear Power - a Business Driver for the Next Generation'; and, 'Designing - the Next Generation'. The technical session titles were: Reactor and Radiation Physics; Environment and Spent Fuel Management; Operations and Maintenance; Fusion Science and Technology; Advanced Reactors and Fuels; Plant Life Extension, Refurbishment and Aging; Safety and Licensing; Chemistry and Materials; and, Thermalhydraulics. The student conference session was well attended and completed the 4 day event.

AGIS: A Next-generation TeV Gamma-ray Observatory

Science.gov (United States)

Vandenbroucke, Justin

2010-05-01

The Advanced Gamma-ray Imaging System (AGIS) is a next-generation array of imaging atmospheric Cherenkov telescopes for gamma-ray astronomy in the 100 GeV to 100 TeV band. TeV astronomy has flourished in the last few years. Together with the extremely successful first year of the Fermi LAT telescope for GeV gamma-ray astronomy, we are now in a golden age of gamma-ray astronomy. AGIS seeks to continue the success of gamma-ray astronomy by discovering hundreds of new TeV sources and improving our understanding of known sources, as well as searching for signals from dark matter annihilation. AGIS will feature 36 Schwarzschild-Couder (SC) telescopes spanning 1 km2. The two-mirror SC design allows a wide field of view (8 deg diameter) and high-resolution (0.05 deg diameter) pixellation. I will present the science capabilities of the AGIS observatory as well as the technical design and current status of the project.

Design and analysis of the federal aviation administration next generation fire test burner

Science.gov (United States)

Ochs, Robert Ian

The United States Federal Aviation Administration makes use of threat-based fire test methods for the certification of aircraft cabin materials to enhance the level of safety in the event of an in-flight or post-crash fire on a transport airplane. The global nature of the aviation industry results in these test methods being performed at hundreds of laboratories around the world; in some cases testing identical materials at multiple labs but yielding different results. Maintenance of this standard for an elevated level of safety requires that the test methods be as well defined as possible, necessitating a comprehensive understanding of critical test method parameters. The tests have evolved from simple Bunsen burner material tests to larger, more complicated apparatuses, requiring greater understanding of the device for proper application. The FAA specifies a modified home heating oil burner to simulate the effects of large, intense fires for testing of aircraft seat cushions, cargo compartment liners, power plant components, and thermal acoustic insulation. Recently, the FAA has developed a Next Generation (NexGen) Fire Test burner to replace the original oil burner that has become commercially unavailable. The NexGen burner design is based on the original oil burner but with more precise control of the air and fuel flow rates with the addition of a sonic nozzle and a pressurized fuel system. Knowledge of the fundamental flow properties created by various burner configurations is desired to develop an updated and standardized burner configuration for use around the world for aircraft materials fire testing and airplane certification. To that end, the NexGen fire test burner was analyzed with Particle Image Velocimetry (PIV) to resolve the non-reacting exit flow field and determine the influence of the configuration of burner components. The correlation between the measured flow fields and the standard burner performance metrics of flame temperature and

Application of mechanistic models to fermentation and biocatalysis for next-generation processes

DEFF Research Database (Denmark)

Gernaey, Krist; Eliasson Lantz, Anna; Tufvesson, Pär

2010-01-01

of variables required for measurement, control and process design. In the near future, mechanistic models with a higher degree of detail will play key roles in the development of efficient next-generation fermentation and biocatalytic processes. Moreover, mechanistic models will be used increasingly......Mechanistic models are based on deterministic principles, and recently, interest in them has grown substantially. Herein we present an overview of mechanistic models and their applications in biotechnology, including future perspectives. Model utility is highlighted with respect to selection...

Educating the next generation of nature entrepreneurs

Science.gov (United States)

Judith C. Jobse; Loes Witteveen; Judith Santegoets; Daan van der Linde

2015-01-01

With this paper, it is illustrated that a focus on entrepreneurship training in the nature and wilderness sector is relevant for diverse organisations and situations. The first curricula on nature entrepreneurship are currently being developed. In this paper the authors describe a project that focusses on educating the next generation of nature entrepreneurs, reflect...

The Next Generation: Students Discuss Archaeology in the 21st Century

OpenAIRE

Sands, Ashley; Butler, Kristin

2010-01-01

The Next Generation Project is a multi-agent, multi-directional cultural diplomacy effort. The need for communication among emerging archaeologists has never been greater. Increasingly, archaeological sites are impacted by military activity, destroyed through the development of dams and building projects, and torn apart through looting. The Next Generation Project works to develop communication via social networking sites online and through in-person meetings at international conferences. As ...

Advanced Combustion Systems for Next Generation Gas Turbines

Energy Technology Data Exchange (ETDEWEB)

Joel Haynes; Jonathan Janssen; Craig Russell; Marcus Huffman

2006-01-01

Next generation turbine power plants will require high efficiency gas turbines with higher pressure ratios and turbine inlet temperatures than currently available. These increases in gas turbine cycle conditions will tend to increase NOx emissions. As the desire for higher efficiency drives pressure ratios and turbine inlet temperatures ever higher, gas turbines equipped with both lean premixed combustors and selective catalytic reduction after treatment eventually will be unable to meet the new emission goals of sub-3 ppm NOx. New gas turbine combustors are needed with lower emissions than the current state-of-the-art lean premixed combustors. In this program an advanced combustion system for the next generation of gas turbines is being developed with the goal of reducing combustor NOx emissions by 50% below the state-of-the-art. Dry Low NOx (DLN) technology is the current leader in NOx emission technology, guaranteeing 9 ppm NOx emissions for heavy duty F class gas turbines. This development program is directed at exploring advanced concepts which hold promise for meeting the low emissions targets. The trapped vortex combustor is an advanced concept in combustor design. It has been studied widely for aircraft engine applications because it has demonstrated the ability to maintain a stable flame over a wide range of fuel flow rates. Additionally, it has shown significantly lower NOx emission than a typical aircraft engine combustor and with low CO at the same time. The rapid CO burnout and low NOx production of this combustor made it a strong candidate for investigation. Incremental improvements to the DLN technology have not brought the dramatic improvements that are targeted in this program. A revolutionary combustor design is being explored because it captures many of the critical features needed to significantly reduce emissions. Experimental measurements of the combustor performance at atmospheric conditions were completed in the first phase of the program

Comparison of the performance of the next generation of optical interferometers

Science.gov (United States)

Pisani, Marco; Yacoot, Andrew; Balling, Petr; Bancone, Nicola; Birlikseven, Cengiz; Çelik, Mehmet; Flügge, Jens; Hamid, Ramiz; Köchert, Paul; Kren, Petr; Kuetgens, Ulrich; Lassila, Antti; Bartolo Picotto, Gian; Şahin, Ersoy; Seppä, Jeremias; Tedaldi, Matthew; Weichert, Christoph

2012-08-01

Six European National Measurement Institutes (NMIs) have joined forces within the European Metrology Research Programme funded project NANOTRACE to develop the next generation of optical interferometers having a target uncertainty of 10 pm. These are needed for NMIs to provide improved traceable dimensional metrology that can be disseminated to the wider nanotechnology community, thereby supporting the growth in nanotechnology. Several approaches were followed in order to develop the interferometers. This paper briefly describes the different interferometers developed by the various partners and presents the results of a comparison of performance of the optical interferometers using an x-ray interferometer to generate traceable reference displacements.

A Methodology for Physical Interconnection Decisions of Next Generation Transport Networks

DEFF Research Database (Denmark)

Gutierrez Lopez, Jose Manuel; Riaz, M. Tahir; Madsen, Ole Brun

2011-01-01

of possibilities when designing the physical network interconnection. This paper develops and presents a methodology in order to deal with aspects related to the interconnection problem of optical transport networks. This methodology is presented as independent puzzle pieces, covering diverse topics going from......The physical interconnection for optical transport networks has critical relevance in the overall network performance and deployment costs. As telecommunication services and technologies evolve, the provisioning of higher capacity and reliability levels is becoming essential for the proper...... development of Next Generation Networks. Currently, there is a lack of specific procedures that describe the basic guidelines to design such networks better than "best possible performance for the lowest investment". Therefore, the research from different points of view will allow a broader space...

Development of Next-Generation LWR (Light Water Reactor) in Japan

International Nuclear Information System (INIS)

Yamamoto, T.; Kasai, S.

2011-01-01

The Next-Generation Light Water Reactor development program was launched in Japan in April 2008. The primary objective of the program is to cope with the need to replace existing nuclear power plants in Japan after 2030. The reactors to be developed are also expected to be a global standard design. Several innovative features are envisioned, including a reactor core system with uranium enrichment above 5%, a seismic isolation system, the use of long-life materials and innovative water chemistry, innovative construction techniques, safety systems with the best mix of passive and active concepts, and innovative digital technologies to further enhance reactor safety, reliability, economics, etc. In the first 3 years, a plant design concept with these innovative features is established and the effectiveness of the program is reevaluated. The major part of the program will be completed in 2015. (author)

Flux gain for a next-generation neutron reflectometer resulting from improved supermirror performance

CERN Document Server

Rehm, C

2002-01-01

Next-generation spallation neutron source facilities will offer instruments with unprecedented capabilities through simultaneous enhancement of source power and usage of advanced optical components. The Spallation Neutron Source (SNS), already under construction at Oak Ridge National Laboratory and scheduled to be completed by 2006, will provide greater than an order of magnitude more effective source flux than current state-of-the-art facilities, including the most advanced research reactors. An additional order of magnitude gain is expected through the use of new optical devices and instrumentation concepts. Many instrument designs require supermirror neutron guides with very high critical angles for total reflection. In this contribution, we will discuss how the performance of a modern neutron-scattering instrument depends on the efficiency of these supermirrors. We summarize current limitations of supermirror coatings and outline ideas for enhancing their performance, particularly for improving the reflec...

The next generation of CANDU technologies: profiling the potential for hydrogen fuel

International Nuclear Information System (INIS)

Hopwood, J.M.

2001-01-01

This report discusses the Next-generation CANDU Power Reactor technologies currently under development at AECL. The innovations introduced into proven CANDU technologies include a compact reactor core design, which reduces the size by a factor of one third for the same power output; improved thermal efficiency through higher-pressure steam turbines; reduced use of heavy water (one quarter of the heavy water required for existing plants), thus reducing the cost and eliminating many material handling concerns; use of slightly enriched uranium to extend fuel life to three times that of existing natural uranium fuel and additions to CANDU's inherent passive safety. With these advanced features, the capital cost of constructing the plant can be reduced by up to 40 per cent compared to existing designs. The clean, affordable CANDU-generated electricity can be used to produce hydrogen for fuel cells for the transportation sector, thereby reducing emissions from the transportation sector

Digital Earth reloaded – Beyond the next generation

International Nuclear Information System (INIS)

Ehlers, M; Woodgate, P; Annoni, A; Schade, S

2014-01-01

Digital replicas (or 'mirror worlds') of complex entities and systems are now routine in many fields such as aerospace engineering; archaeology; medicine; or even fashion design. The Digital Earth (DE) concept as a digital replica of the entire planet occurs in Al Gore's 1992 book Earth in the Balance and was popularized in his speech at the California Science Center in January 1998. It played a pivotal role in stimulating the development of a first generation of virtual globes, typified by Google Earth that achieved many elements of this vision. Almost 15 years after Al Gore's speech, the concept of DE needs to be re-evaluated in the light of the many scientific and technical developments in the fields of information technology, data infrastructures, citizen?s participation, and earth observation that have taken place since. This paper intends to look beyond the next generation predominantly based on the developments of fields outside the spatial sciences, where concepts, software, and hardware with strong relationships to DE are being developed without referring to this term. It also presents a number of guiding criteria for future DE developments

Next Generation, Si-Compatible Materials and Devices in the Si-Ge-Sn System

Science.gov (United States)

2015-10-09

and conclusions The work initially focused on growth of next generation Ge1-ySny alloys on Ge buffered Si wafers via UHV CVD depositions of Ge3H8...Abstract The work initially focused on growth of next generation Ge1-ySny alloys on Ge buffered Si wafers via UHV CVD depositions of Ge3H8, SnD4. The...AFRL-AFOSR-VA-TR-2016-0044 Next generation, Si -compatible materials and devices in the Si - Ge -Sn system John Kouvetakis ARIZONA STATE UNIVERSITY Final

Production of the next-generation library virtual tour

Science.gov (United States)

Duncan, James M.; Roth, Linda K.

2001-01-01

While many libraries offer overviews of their services through their Websites, only a small number of health sciences libraries provide Web-based virtual tours. These tours typically feature photographs of major service areas along with textual descriptions. This article describes the process for planning, producing, and implementing a next-generation virtual tour in which a variety of media elements are integrated: photographic images, 360-degree “virtual reality” views, textual descriptions, and contextual floor plans. Hardware and software tools used in the project are detailed, along with a production timeline and budget, tips for streamlining the process, and techniques for improving production. This paper is intended as a starting guide for other libraries considering an investment in such a project. PMID:11837254

Flux Gain for Next-Generation Neutron-Scattering Instruments Resulting From Improved Supermirror Performance

International Nuclear Information System (INIS)

Rehm, C.

2001-01-01

Next-generation spallation neutron source facilities will offer instruments with unprecedented capabilities through simultaneous enhancement of source power and usage of advanced optical components. The Spallation Neutron Source (SNS), already under construction at Oak Ridge National Laboratory and scheduled to be completed by 2006, will provide greater than an order of magnitude more effective source flux than current state-of-the-art facilities, including the most advanced research reactors. An additional order of magnitude gain is expected through the use of new optical devices and instrumentation concepts. Many instrument designs require supermirror (SM) neutron guides with very high critical angles for total reflection. In this contribution, they discuss how the performance of modern neutron scattering instruments depends on the efficiency of these supermirrors. They outline ideas for enhancing the performance of the SM coatings, particularly for improving the reflectivity at the position of the critical wave vector transfer. A simulation program has been developed which allows different approaches for SM designs to be studied. Possible instrument performance gains are calculated for the example of the SNS reflectometer

A Framework for the Next Generation of Risk Science

Science.gov (United States)

Krewski, Daniel; Andersen, Melvin E.; Paoli, Gregory M.; Chiu, Weihsueh A.; Al-Zoughool, Mustafa; Croteau, Maxine C.; Burgoon, Lyle D.; Cote, Ila

2014-01-01

Objectives: In 2011, the U.S. Environmental Protection Agency initiated the NexGen project to develop a new paradigm for the next generation of risk science. Methods: The NexGen framework was built on three cornerstones: the availability of new data on toxicity pathways made possible by fundamental advances in basic biology and toxicological science, the incorporation of a population health perspective that recognizes that most adverse health outcomes involve multiple determinants, and a renewed focus on new risk assessment methodologies designed to better inform risk management decision making. Results: The NexGen framework has three phases. Phase I (objectives) focuses on problem formulation and scoping, taking into account the risk context and the range of available risk management decision-making options. Phase II (risk assessment) seeks to identify critical toxicity pathway perturbations using new toxicity testing tools and technologies, and to better characterize risks and uncertainties using advanced risk assessment methodologies. Phase III (risk management) involves the development of evidence-based population health risk management strategies of a regulatory, economic, advisory, community-based, or technological nature, using sound principles of risk management decision making. Conclusions: Analysis of a series of case study prototypes indicated that many aspects of the NexGen framework are already beginning to be adopted in practice. Citation: Krewski D, Westphal M, Andersen ME, Paoli GM, Chiu WA, Al-Zoughool M, Croteau MC, Burgoon LD, Cote I. 2014. A framework for the next generation of risk science. Environ Health Perspect 122:796–805; http://dx.doi.org/10.1289/ehp.1307260 PMID:24727499

Designing next-generation platforms for evaluating scientific output: What scientists can learn from the social web

Directory of Open Access Journals (Sweden)

Tal eYarkoni

2012-10-01

Full Text Available Traditional pre-publication peer review of scientific output is a slow, inefficient, and unreliable process. Efforts to replace or supplement traditional evaluation models with open evaluation platforms that leverage advances in information technology are slowly gaining traction, but remain in the early stages of design and implementation. Here I discuss a number of considerations relevant to the development of such platforms. I focus particular attention on three core elements that next-generation evaluation platforms should strive to emphasize, including (a open and transparent access to accumulated evaluation data, (b personalized and highly customizable performance metrics, and (c appropriate short-term incentivization of the userbase. Because all of these elements have already been successfully implemented on a large scale in hundreds of existing social web applications, I argue that development of new scientific evaluation platforms should proceed largely by adapting existing techniques rather than engineering entirely new evaluation mechanisms. Successful implementation of open evaluation platforms has the potential to substantially advance both the pace and the quality of scientific publication and evaluation, and the scientific community has a vested interest in shifting towards such models as soon as possible.

Site Selection and Characterization Status Report for Next Generation Nuclear Plant (NGNP)

International Nuclear Information System (INIS)

Holbrook, Mark

2007-01-01

In the near future, the US Department of Energy (DOE) will need to make important decisions regarding design and construction of the Next Generation Nuclear Plant (NGNP). One part of making these decisions is considering the potential environmental impacts that this facility may have, if constructed here at the Idaho National Laboratory (INL). The National Environmental Policy Act (NEPA) of 1969 provides DOE decision makers with a process to systematically consider potential environmental consequences of agency decisions. In addition, the Energy Policy Act of 2005 (Title VI, Subtitel C, Section 644) states that the 'Nuclear Regulatory Commission (NRC) shall have licensing and regulatory authority for any reactor authorized under this subtitle.' This stipulates that the NRC will license the NGNP for operation. The NRC NEPA Regulations (10 CFR Part 51) require tha thte NRC prepare an Environmental Impact Statement (EIS) for a permit to construct a nuclear power plant. The applicant is required to submit an Environmental report (ER) to aid the NRC in complying with NEPA.

NEXT GENERATION TURBINE PROGRAM

Energy Technology Data Exchange (ETDEWEB)

William H. Day

2002-05-03

The Next Generation Turbine (NGT) Program's technological development focused on a study of the feasibility of turbine systems greater than 30 MW that offer improvement over the 1999 state-of-the-art systems. This program targeted goals of 50 percent turndown ratios, 15 percent reduction in generation cost/kW hour, improved service life, reduced emissions, 400 starts/year with 10 minutes to full load, and multiple fuel usage. Improvement in reliability, availability, and maintainability (RAM), while reducing operations, maintenance, and capital costs by 15 percent, was pursued. This program builds on the extensive low emissions stationary gas turbine work being carried out by Pratt & Whitney (P&W) for P&W Power Systems (PWPS), which is a company under the auspices of the United Technologies Corporation (UTC). This study was part of the overall Department of Energy (DOE) NGT Program that extends out to the year 2008. A follow-on plan for further full-scale component hardware testing is conceptualized for years 2002 through 2008 to insure a smooth and efficient transition to the marketplace for advanced turbine design and cycle technology. This program teamed the National Energy Technology Laboratory (NETL), P&W, United Technologies Research Center (UTRC), kraftWork Systems Inc., a subcontractor on-site at UTRC, and Multiphase Power and Processing Technologies (MPPT), an off-site subcontractor. Under the auspices of the NGT Program, a series of analyses were performed to identify the NGT engine system's ability to serve multiple uses. The majority were in conjunction with a coal-fired plant, or used coal as the system fuel. Identified also was the ability of the NGT system to serve as the basis of an advanced performance cycle: the humid air turbine (HAT) cycle. The HAT cycle is also used with coal gasification in an integrated cycle HAT (IGHAT). The NGT systems identified were: (1) Feedwater heating retrofit to an existing coal-fired steam plant, which

Bioinformatics for Next Generation Sequencing Data

Directory of Open Access Journals (Sweden)

Alberto Magi

2010-09-01

Full Text Available The emergence of next-generation sequencing (NGS platforms imposes increasing demands on statistical methods and bioinformatic tools for the analysis and the management of the huge amounts of data generated by these technologies. Even at the early stages of their commercial availability, a large number of softwares already exist for analyzing NGS data. These tools can be fit into many general categories including alignment of sequence reads to a reference, base-calling and/or polymorphism detection, de novo assembly from paired or unpaired reads, structural variant detection and genome browsing. This manuscript aims to guide readers in the choice of the available computational tools that can be used to face the several steps of the data analysis workflow.

Proposal and analysis of the benchmark problem suite for reactor physics study of LWR next generation fuels

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-10-01

In order to investigate the calculation accuracy of the nuclear characteristics of LWR next generation fuels, the Research Committee on Reactor Physics organized by JAERI has established the Working Party on Reactor Physics for LWR Next Generation Fuels. The next generation fuels mean the ones aiming for further extended burn-up such as 70 GWd/t over the current design. The Working Party has proposed six benchmark problems, which consists of pin-cell, PWR fuel assembly and BWR fuel assembly geometries loaded with uranium and MOX fuels, respectively. The specifications of the benchmark problem neglect some of the current limitations such as 5 wt% {sup 235}U to achieve the above-mentioned target. Eleven organizations in the Working Party have carried out the analyses of the benchmark problems. As a result, status of accuracy with the current data and method and some problems to be solved in the future were clarified. In this report, details of the benchmark problems, result by each organization, and their comparisons are presented. (author)

Next Generation HeliMag UXO Mapping Technology

Science.gov (United States)

2010-01-01

Ancillary instrumentation records aircraft height above ground and attitude. A fluxgate magnetometer is used to allow for aeromagnetic compensation of... Magnetometer System WWII World War II WAA wide area assessment ACKNOWLEDGEMENTS This Next Generation HeliMag Unexploded Ordnance (UXO) Mapping...for deployment of seven total-field magnetometers on a Kevlar reinforced boom mounted on a Bell 206L helicopter. The objectives of this

Application of Next Generation Sequencing on Genetic Testing

DEFF Research Database (Denmark)

Li, Jian

The discovery of genetic factors behind increasing number of human diseases and the growth of education of genetic knowledge to the public make demands for genetic testing increase rapidly. However, traditional genetic testing methods cannot meet all kinds of the requirements. Next generation seq...

HLA typing: Conventional techniques v. next-generation sequencing ...

African Journals Online (AJOL)

Background. The large number of population-specific polymorphisms present in the HLA complex in the South African (SA) population reduces the probability of finding an adequate HLA-matched donor for individuals in need of an unrelated haematopoietic stem cell transplantation (HSCT). Next-generation sequencing ...

NGSS and the Next Generation of Science Teachers

Science.gov (United States)

Bybee, Rodger W.

2014-01-01

This article centers on the "Next Generation Science Standards" (NGSS) and their implications for teacher development, particularly at the undergraduate level. After an introduction to NGSS and the influence of standards in the educational system, the article addresses specific educational shifts--interconnecting science and engineering…

Smart Energy Cryo-refrigerator Technology for the next generation Very Large Array

Science.gov (United States)

Spagna, Stefano

2018-01-01

We describe a “smart energy” cryocooler technology architecture for the next generation Very Large Array that makes use of multiple variable frequency cold heads driven from a single variable speed air cooled compressor. Preliminary experiments indicate that the compressor variable flow control, advanced diagnostics, and the cryo-refrigerator low vibration, provide a unique energy efficient capability for the very large number of antennas that will be employed in this array.

Advanced Material Strategies for Next-Generation Additive Manufacturing.

Science.gov (United States)

Chang, Jinke; He, Jiankang; Mao, Mao; Zhou, Wenxing; Lei, Qi; Li, Xiao; Li, Dichen; Chua, Chee-Kai; Zhao, Xin

2018-01-22

Additive manufacturing (AM) has drawn tremendous attention in various fields. In recent years, great efforts have been made to develop novel additive manufacturing processes such as micro-/nano-scale 3D printing, bioprinting, and 4D printing for the fabrication of complex 3D structures with high resolution, living components, and multimaterials. The development of advanced functional materials is important for the implementation of these novel additive manufacturing processes. Here, a state-of-the-art review on advanced material strategies for novel additive manufacturing processes is provided, mainly including conductive materials, biomaterials, and smart materials. The advantages, limitations, and future perspectives of these materials for additive manufacturing are discussed. It is believed that the innovations of material strategies in parallel with the evolution of additive manufacturing processes will provide numerous possibilities for the fabrication of complex smart constructs with multiple functions, which will significantly widen the application fields of next-generation additive manufacturing.

Advanced Material Strategies for Next-Generation Additive Manufacturing

Directory of Open Access Journals (Sweden)

Jinke Chang

2018-01-01

Full Text Available Additive manufacturing (AM has drawn tremendous attention in various fields. In recent years, great efforts have been made to develop novel additive manufacturing processes such as micro-/nano-scale 3D printing, bioprinting, and 4D printing for the fabrication of complex 3D structures with high resolution, living components, and multimaterials. The development of advanced functional materials is important for the implementation of these novel additive manufacturing processes. Here, a state-of-the-art review on advanced material strategies for novel additive manufacturing processes is provided, mainly including conductive materials, biomaterials, and smart materials. The advantages, limitations, and future perspectives of these materials for additive manufacturing are discussed. It is believed that the innovations of material strategies in parallel with the evolution of additive manufacturing processes will provide numerous possibilities for the fabrication of complex smart constructs with multiple functions, which will significantly widen the application fields of next-generation additive manufacturing.

Advanced Material Strategies for Next-Generation Additive Manufacturing

Science.gov (United States)

Chang, Jinke; He, Jiankang; Zhou, Wenxing; Lei, Qi; Li, Xiao; Li, Dichen

2018-01-01

Additive manufacturing (AM) has drawn tremendous attention in various fields. In recent years, great efforts have been made to develop novel additive manufacturing processes such as micro-/nano-scale 3D printing, bioprinting, and 4D printing for the fabrication of complex 3D structures with high resolution, living components, and multimaterials. The development of advanced functional materials is important for the implementation of these novel additive manufacturing processes. Here, a state-of-the-art review on advanced material strategies for novel additive manufacturing processes is provided, mainly including conductive materials, biomaterials, and smart materials. The advantages, limitations, and future perspectives of these materials for additive manufacturing are discussed. It is believed that the innovations of material strategies in parallel with the evolution of additive manufacturing processes will provide numerous possibilities for the fabrication of complex smart constructs with multiple functions, which will significantly widen the application fields of next-generation additive manufacturing. PMID:29361754

Permanent magnet based dipole magnets for next generation light sources

Directory of Open Access Journals (Sweden)

Takahiro Watanabe

2017-07-01

Full Text Available We have developed permanent magnet based dipole magnets for the next generation light sources. Permanent magnets are advantageous over electromagnets in that they consume less power, are physically more compact, and there is a less risk of power supply failure. However, experience with electromagnets and permanent magnets in the field of accelerators shows that there are still challenges to replacing main magnets of accelerators for light sources with permanent magnets. These include the adjustability of the magnetic field, the temperature dependence of permanent magnets, and the issue of demagnetization. In this paper, we present a design for magnets for future light sources, supported by experimental and numerical results.

Report on the international workshop on next generation linear colliders

International Nuclear Information System (INIS)

Ruth, R.D.

1989-05-01

Many laboratories around the world have begun vigorous research programs on a next generation linear collider (NLC). However, it has been recognized that the research towards NLC is beyond the capabilities of any one laboratory presently. This workshop was organized to begin a series of workshops that address this problem. Specifically, the main goals of the workshop were to discuss research programs of the various laboratories around the world, to identify common areas of interest in the various NLC designs, and finally to advance these programs by collaboration. The particular topics discussed briefly in this paper are: parameters, rf power, structures, final focus, beam dynamics, damping rings, and instrumentation. 2 refs., 3 figs., 6 tabs

GeMini: The Next-Generation Mechanically-Cooled Germanium Spectrometer

Energy Technology Data Exchange (ETDEWEB)

Burks, M

2008-11-12

The next-generation mechanically-cooled germanium spectrometer has been developed. GeMini (MINIature GErmanium spectrometer) has been designed to bring high-resolution gamma-ray spectroscopy to a range of demanding field environments. Intended applications include short-notice inspections, border patrol, port monitoring and emergency response, where positive nuclide identification of radioactive materials is required but power and liquid cryogen are not easily available. GeMini weighs 2.75 kg for the basic instrument and 4.5 kg for the full instrument including user interface and ruggedized hermetic packaging. It is very low power allowing it to operate for 10 hours on a single set of rechargeable batteries. This instrument employs technology adapted from the gamma-ray spectrometer currently flying on NASA's Mercury MESSENGER spacecraft. Specifically, infrared shielding techniques allow for a vast reduction of thermal load. This in turn allows for a smaller, lighter-weight design, well-suited for a hand-held instrument. Three working prototypes have been built and tested in the lab. The measured energy resolution is 3 keV fwhm at 662 keV gamma-rays. This paper will focus on the design and performance of the instrument.

Next Generation Nuclear Plant GAP Analysis Report

Energy Technology Data Exchange (ETDEWEB)

Ball, Sydney J [ORNL; Burchell, Timothy D [ORNL; Corwin, William R [ORNL; Fisher, Stephen Eugene [ORNL; Forsberg, Charles W. [Massachusetts Institute of Technology (MIT); Morris, Robert Noel [ORNL; Moses, David Lewis [ORNL

2008-12-01

As a follow-up to the phenomena identification and ranking table (PIRT) studies conducted recently by NRC on next generation nuclear plant (NGNP) safety, a study was conducted to identify the significant 'gaps' between what is needed and what is already available to adequately assess NGNP safety characteristics. The PIRT studies focused on identifying important phenomena affecting NGNP plant behavior, while the gap study gives more attention to off-normal behavior, uncertainties, and event probabilities under both normal operation and postulated accident conditions. Hence, this process also involved incorporating more detailed evaluations of accident sequences and risk assessments. This study considers thermal-fluid and neutronic behavior under both normal and postulated accident conditions, fission product transport (FPT), high-temperature metals, and graphite behavior and their effects on safety. In addition, safety issues related to coupling process heat (hydrogen production) systems to the reactor are addressed, given the limited design information currently available. Recommendations for further study, including analytical methods development and experimental needs, are presented as appropriate in each of these areas.

Next generation network based carrier ethernet test bed for IPTV traffic

DEFF Research Database (Denmark)

Fu, Rong; Berger, Michael Stübert; Zheng, Yu

2009-01-01

This paper presents a Carrier Ethernet (CE) test bed based on the Next Generation Network (NGN) framework. After the concept of CE carried out by Metro Ethernet Forum (MEF), the carrier-grade Ethernet are obtaining more and more interests and being investigated as the low cost and high performanc...... services of transport network to carry the IPTV traffic. This test bed is approaching to support the research on providing a high performance carrier-grade Ethernet transport network for IPTV traffic....

3D-SoftChip: A Novel Architecture for Next-Generation Adaptive Computing Systems

Directory of Open Access Journals (Sweden)

Lee Mike Myung-Ok

2006-01-01

Full Text Available This paper introduces a novel architecture for next-generation adaptive computing systems, which we term 3D-SoftChip. The 3D-SoftChip is a 3-dimensional (3D vertically integrated adaptive computing system combining state-of-the-art processing and 3D interconnection technology. It comprises the vertical integration of two chips (a configurable array processor and an intelligent configurable switch through an indium bump interconnection array (IBIA. The configurable array processor (CAP is an array of heterogeneous processing elements (PEs, while the intelligent configurable switch (ICS comprises a switch block, 32-bit dedicated RISC processor for control, on-chip program/data memory, data frame buffer, along with a direct memory access (DMA controller. This paper introduces the novel 3D-SoftChip architecture for real-time communication and multimedia signal processing as a next-generation computing system. The paper further describes the advanced HW/SW codesign and verification methodology, including high-level system modeling of the 3D-SoftChip using SystemC, being used to determine the optimum hardware specification in the early design stage.

Development of High Frequency Transition-Edge-Sensor Polarimeters for Next Generation Cosmic Microwave Background Experiments and Galactic Foreground Measurements

Science.gov (United States)

Walker, Samantha; Sierra, Carlos E.; Austermann, Jason Edward; Beall, James; Becker, Dan; Dober, Bradley; Duff, Shannon; Hilton, Gene; Hubmayr, Johannes; Van Lanen, Jeffrey L.; McMahon, Jeff; Simon, Sara M.; Ullom, Joel; Vissers, Michael R.; NIST Quantum Sensors Group

2018-06-01

Observations of the cosmic microwave background (CMB) provide a powerful tool for probing the earliest moments of the universe and therefore have the potential to transform our understanding of cosmology. In particular, precision measurements of its polarization can reveal the existence of gravitational waves produced during cosmic inflation. However, these observations are complicated by the presence of astrophysical foregrounds, which may be separated by using broad frequency coverage, as the spectral energy distribution between foregrounds and the CMB is distinct. For this purpose, we are developing large-bandwidth, feedhorn-coupled transition-edge-sensor (TES) arrays that couple polarized light from waveguide to superconducting microstrip by use of a symmetric, planar orthomode transducer (OMT). In this work, we describe two types of pixels, an ultra-high frequency (UHF) design, which operates from 195 GHz-315 GHz, and an extended ultra-high frequency (UHF++) design, which operates from 195 GHz-420 GHz, being developed for next generation CMB experiments that will come online in the next decade, such as CCAT-prime and the Simons Observatory. We present the designs, simulation results, fabrication, and preliminary measurements of these prototype pixels.

NOAA Next Generation Radar (NEXRAD) Level 2 Base Data

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level II weather radar data collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska, Hawaii,...

Next Generation Nuclear Plant Project Preliminary Project Management Plan

International Nuclear Information System (INIS)

Dennis J. Harrell

2006-01-01

This draft preliminary project management plan presents the conceptual framework for the Next Generation Nuclear Plant (NGNP) Project, consistent with the authorization in the Energy Policy Act of 2005. In developing this plan, the Idaho National Laboratory has considered three fundamental project planning options that are summarized in the following section. Each of these planning options is literally compliant with the Energy Policy Act of 2005, but each emphasizes different approaches to technology development risks, design, licensing and construction risks, and to the extent of commercialization support provided to the industry. The primary focus of this draft preliminary project management plan is to identify those activities important to Critical Decision-1, at which point a decision on proceeding with the NGNP Project can be made. The conceptual project framework described herein is necessary to establish the scope and priorities for the technology development activities. The framework includes: A reference NGNP prototype concept based on what is judged to be the lowest risk technology development that would achieve the needed commercial functional requirements to provide an economically competitive nuclear heat source and hydrogen production capability. A high-level schedule logic for design, construction, licensing, and acceptance testing. This schedule logic also includes an operational shakedown period that provides proof-of-principle to establish the basis for commercialization decisions by end-users. An assessment of current technology development plans to support Critical Decision-1 and overall project progress. The most important technical and programmatic uncertainties (risks) are evaluated, and potential mitigation strategies are identified so that the technology development plans may be modified as required to support ongoing project development. A rough-order-of-magnitude cost evaluation that provides an initial basis for budget planning. This

76 FR 77939 - Proposed Provision of Navigation Services for the Next Generation Air Transportation System...

Science.gov (United States)

2011-12-15

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Parts 91, 121, 125, 129, and 135 Proposed Provision of Navigation Services for the Next Generation Air Transportation System (Next...) navigation infrastructure to enable performance-based navigation (PBN) as part of the Next Generation Air...

Cloud Sourcing – Next Generation Outsourcing?

OpenAIRE

Muhic, Mirella; Johansson, Björn

2014-01-01

Although Cloud Sourcing has been around for some time it could be questioned what actually is known about it. This paper presents a literature review on the specific question if Cloud Sourcing could be seen as the next generation of outsourcing. The reason for doing this is that from an initial sourcing study we found that the sourcing decisions seems to go in the direction of outsourcing as a service which could be described as Cloud Sourcing. Whereas some are convinced that Cloud Sourcing r...

Securing Networks from Modern Threats using Next Generation Firewalls

OpenAIRE

Delgiusto, Valter

2016-01-01

Classic firewalls have long been unable to cope with modern threats that ordinary Internet users are exposed to. This thesis discusses their successors - the next-generation firewalls. The first part of the thesis describes modern threats and attacks. We described in detail the DoS and APT attacks, which are among the most frequent and which may cause most damage to the system under attack. Then we explained the theoretical basics of firewalls and described the functionalities of next gen...

Next generation of energy production systems

International Nuclear Information System (INIS)

Rouault, J.; Garnier, J.C.; Carre, F.

2003-01-01

This document gathers the slides that have been presented at the Gedepeon conference. Gedepeon is a research group involving scientists from Cea (French atomic energy commission), CNRS (national center of scientific research), EDF (electricity of France) and Framatome that is devoted to the study of new energy sources and particularly to the study of the future generations of nuclear systems. The contributions have been classed into 9 topics: 1) gas cooled reactors, 2) molten salt reactors (MSBR), 3) the recycling of plutonium and americium, 4) reprocessing of molten salt reactor fuels, 5) behavior of graphite under radiation, 6) metallic materials for molten salt reactors, 7) refractory fuels of gas cooled reactors, 8) the nuclear cycle for the next generations of nuclear systems, and 9) organization of research programs on the new energy sources

Next generation of weather generators on web service framework

Science.gov (United States)

Chinnachodteeranun, R.; Hung, N. D.; Honda, K.; Ines, A. V. M.

2016-12-01

Weather generator is a statistical model that synthesizes possible realization of long-term historical weather in future. It generates several tens to hundreds of realizations stochastically based on statistical analysis. Realization is essential information as a crop modeling's input for simulating crop growth and yield. Moreover, they can be contributed to analyzing uncertainty of weather to crop development stage and to decision support system on e.g. water management and fertilizer management. Performing crop modeling requires multidisciplinary skills which limit the usage of weather generator only in a research group who developed it as well as a barrier for newcomers. To improve the procedures of performing weather generators as well as the methodology to acquire the realization in a standard way, we implemented a framework for providing weather generators as web services, which support service interoperability. Legacy weather generator programs were wrapped in the web service framework. The service interfaces were implemented based on an international standard that was Sensor Observation Service (SOS) defined by Open Geospatial Consortium (OGC). Clients can request realizations generated by the model through SOS Web service. Hierarchical data preparation processes required for weather generator are also implemented as web services and seamlessly wired. Analysts and applications can invoke services over a network easily. The services facilitate the development of agricultural applications and also reduce the workload of analysts on iterative data preparation and handle legacy weather generator program. This architectural design and implementation can be a prototype for constructing further services on top of interoperable sensor network system. This framework opens an opportunity for other sectors such as application developers and scientists in other fields to utilize weather generators.

Regulatory Concerns on the In-Containment Water Storage System of the Korean Next Generation Reactor

International Nuclear Information System (INIS)

Ahn, Hyung-Joon; Lee, Jae-Hun; Bang, Young-Seok; Kim, Hho-Jung

2002-01-01

The in-containment water storage system (IWSS) is a newly adopted system in the design of the Korean Next Generation Reactor (KNGR). It consists of the in-containment refueling water storage tank, holdup volume tank, and cavity flooding system (CFS). The IWSS has the function of steam condensation and heat sink for the steam release from the pressurizer and provides cooling water to the safety injection system and containment spray system in an accident condition and to the CFS in a severe accident condition. With the progress of the KNGR design, the Korea Institute of Nuclear Safety has been developing Safety and Regulatory Requirements and Guidances for safety review of the KNGR. In this paper, regarding the IWSS of the KNGR, the major contents of the General Safety Criteria, Specific Safety Requirements, Safety Regulatory Guides, and Safety Review Procedures were introduced, and the safety review items that have to be reviewed in-depth from the regulatory viewpoint were also identified

IceCube Gen2. The next-generation neutrino observatory for the South Pole

Energy Technology Data Exchange (ETDEWEB)

Santen, Jakob van [DESY, Zeuthen (Germany); Collaboration: IceCube-Collaboration

2016-07-01

The IceCube Neutrino Observatory is a cubic-kilometer Cherenkov telescope buried in the ice sheet at the South Pole that detects neutrinos of all flavors with energies from tens of GeV to several PeV. The instrument provided the first measurement of the flux of high-energy astrophysical neutrinos, opening a new window to the TeV universe. At the other end of its sensitivity range, IceCube has provided precision measurements of neutrino oscillation parameters that are competitive with dedicated accelerator-based experiments. Here we present design studies for IceCube Gen2, the next-generation neutrino observatory for the South Pole. Instrumenting a volume of more that 5 km{sup 3} with over 100 new strings, IceCube Gen2 will have substantially greater sensitivity to high-energy neutrinos than current-generation instruments. PINGU, a dense infill array, will lower the energy threshold of the inner detector region to 4 GeV, allowing a determination of the neutrino mass hierarchy. On the surface, a large air shower detector will veto high-energy atmospheric muons and neutrinos from the southern hemisphere, enhancing the reach of astrophysical neutrino searches. With its versatile instrumentation, the IceCube Gen2 facility will allow us to explore the neutrino sky with unprecedented sensitivity, providing new constraints on the sources of the highest-energy cosmic rays, and yield precision data on the mixing and mass ordering of neutrinos.

Novel nanostructures for next generation dye-sensitized solar cells

KAUST Repository

Té treault, Nicolas; Grä tzel, Michael

2012-01-01

Herein, we review our latest advancements in nanostructured photoanodes for next generation photovoltaics in general and dye-sensitized solar cells in particular. Bottom-up self-assembly techniques are developed to fabricate large-area 3D

Development of a framework for the neutronics analysis system for next generation (Contract research)

International Nuclear Information System (INIS)

Tatsumi, Masahiro; Yokoyama, Kenji

2007-11-01

In JAEA, authors has been promoting the development of an object-oriented next-generation neutronics analysis system in order to reflect the latest methods and models of reactor analysis to basic designs and operations of fast reactors in the efficient and effective way. A purpose of the developing system is to effectively realize requirements that has been difficult to manage in the conventional systems, such as change of analysis targets and change of analysis modeling levels. For the realization of the requirements, the authors adopted the two-layer model which consists of a control layer written in the Python as an object-oriented scripting language and a solver layer in the C++ as a system programming language. After having studied the principle on the two-layer model in the next-generation neutronics analysis system, the authors designed and implemented a library that enabled transparent transfer of data objects between the two layers. In each layer, appropriate numerical library was used for better performance. In the present library, a model proxy was implemented to exchange internal data that is represented in different ways in each layer. With this mechanism of the model proxy, it confirmed that data exchange between the layers can be performed easily and effectively. (author)

Integrating Communication and Navigation: Next Generation Broadcast Service (NGBS)

Science.gov (United States)

Donaldson, Jennifer

2017-01-01

NASA Goddard has been investing in technology demonstrations of a beacon service, now called Next Generation Broadcast Services (NGBS). NGBS is a global, space-based, communications and navigation service for users of Global Navigation Satellite Systems (GNSS) and the Tracking and Data Relay Satellite System (TDRSS). NGBS will provide an S-band beacon messaging source and radio navigation available to users at orbital altitudes 1400 km and below, increasing the autonomy and resiliency of onboard communication and navigation. NGBS will deliver both one-way radiometric (Doppler and pseudorange) and fast forward data transport services to users. Portions of the overall forward data volume will be allocated for fixed message types while the remaining data volume will be left for user forward command data. The NGBS signal will reside within the 2106.43 MHz spectrum currently allocated for the Space Networks multiple access forward (MAF) service and a live service demonstration is currently being planned via the 2nd and 3rd generation TDRS satellites.

Graphene Transparent Conductive Electrodes for Next- Generation Microshutter Arrays

Science.gov (United States)

Li, Mary; Sultana, Mahmooda; Hess, Larry

2012-01-01

Graphene is a single atomic layer of graphite. It is optically transparent and has high electron mobility, and thus has great potential to make transparent conductive electrodes. This invention contributes towards the development of graphene transparent conductive electrodes for next-generation microshutter arrays. The original design for the electrodes of the next generation of microshutters uses indium-tin-oxide (ITO) as the electrode material. ITO is widely used in NASA flight missions. The optical transparency of ITO is limited, and the material is brittle. Also, ITO has been getting more expensive in recent years. The objective of the invention is to develop a graphene transparent conductive electrode that will replace ITO. An exfoliation procedure was developed to make graphene out of graphite crystals. In addition, large areas of single-layer graphene were produced using low-pressure chemical vapor deposition (LPCVD) with high optical transparency. A special graphene transport procedure was developed for transferring graphene from copper substrates to arbitrary substrates. The concept is to grow large-size graphene sheets using the LPCVD system through chemical reaction, transfer the graphene film to a substrate, dope graphene to reduce the sheet resistance, and pattern the film to the dimension of the electrodes in the microshutter array. Graphene transparent conductive electrodes are expected to have a transparency of 97.7%. This covers the electromagnetic spectrum from UV to IR. In comparison, ITO electrodes currently used in microshutter arrays have 85% transparency in mid-IR, and suffer from dramatic transparency drop at a wavelength of near-IR or shorter. Thus, graphene also has potential application as transparent conductive electrodes for Schottky photodiodes in the UV region.

Next generation WLCG File Transfer Service (FTS)

CERN Multimedia

CERN. Geneva

2012-01-01

LHC experiments at CERN and worldwide utilize WLCG resources and middleware components to perform distributed computing tasks. One of the most important tasks is reliable file replication. It is a complex problem, suffering from transfer failures, disconnections, transfer duplication, server and network overload, differences in storage systems, etc. To address these problems, EMI and gLite have provided the independent File Transfer Service (FTS) and Grid File Access Library (GFAL) tools. Their development started almost a decade ago, in the meantime, requirements in data management have changed - the old architecture of FTS and GFAL cannot keep support easily these changes. Technology has also been progressing: FTS and GFAL do not fit into the new paradigms (cloud, messaging, for example). To be able to serve the next stage of LHC data collecting (from 2013), we need a new generation of  these tools: FTS 3 and GFAL 2. We envision a service requiring minimal configuration, which can dynamically adapt to the...

Preparing the Next Generation of Educators for Democracy

Science.gov (United States)

Embry-Jenlink, Karen

2018-01-01

In the keynote address of the 42nd annual meeting of the Southeastern Regional Educators Association (SRATE), ATE President Karen Embry-Jenlink examines the critical role of teacher educators in preparing the next generation of citizens and leaders to sustain democracy. Drawing from historic and current events and personal experience,…

Next Generation Science Standards: All Standards, All Students

Science.gov (United States)

Lee, Okhee; Miller, Emily C.; Januszyk, Rita

2014-01-01

The Next Generation Science Standards (NGSS) offer a vision of science teaching and learning that presents both learning opportunities and demands for all students, particularly student groups that have traditionally been underserved in science classrooms. The NGSS have addressed issues of diversity and equity from their inception, and the NGSS…

Development of MMIS design concepts for the KNGR

Energy Technology Data Exchange (ETDEWEB)

Park, Jong Kyun; Ku, In Su; Heo, Seop; Jeong, Chel Hwan; Lee, Hyun Chol; Park, Hui Yun; Lee, Chol Gwon; So, Yong Suk; Kim, Dong Hun; Jang, Gwi Sook; Lee, Ki Yonug; Lee, Jun; Kim, Young In [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

1995-12-01

The design goals of MMIS for the next generation nuclear power plant are to improve plant safety and the cost effectiveness of nuclear power plants, and to meet with regulatory requirements. For the optimized design of MMIS, conceptual design bases are required for the optimization of MMIS design to establish the design concepts for NGR MMIS. The conceptual design bases are also required for performing the basic design, and verifying the design. The objectives of this study are establishment of MMIS design bases and the development of next generation MMIS configuration concepts. The MMIS design bases for by adopting MMIS requirements developed in the previous study on next generation reactor evaluation techniques and advanced MMIS technologies. The next generation MMIS design requirements are to be developed based on the device obsolescence problems by applying modern digital technology. This report describes the design concepts for the next generation MMIS. In order to develop the design concepts, new technologies were analyzed, and the characteristics of new advanced MMIS designs were reviewed. In addition, reviewing the advanced design features (ADF) resulted from the 3 rd stage of standardization project, the strategy for the application of the results from these activities are prepared. This report includes the comparison results of the design characteristics of next generation MMIS with those of existing plants, YGN 3 and 4, UCN 3 and 4, and NUPLEX 80+. This report also describes the conceptual MMIS configuration of next generation control room, based on the results from the comparison. The results of this study will be an input for the detailed design guidelines and a regulatory requirements review report for the next generation MMIS design, and provide basis for the basis and detailed design of MMI and I and C for main control room. 1 fig., 1 tab., 46 refs. (Author) .new.

Development of MMIS design concepts for the KNGR

International Nuclear Information System (INIS)

Park, Jong Kyun; Ku, In Su; Heo, Seop; Jeong, Chel Hwan; Lee, Hyun Chol; Park, Hui Yun; Lee, Chol Gwon; So, Yong Suk; Kim, Dong Hun; Jang, Gwi Sook; Lee, Ki Yonug; Lee, Jun; Kim, Young In

1995-12-01

The design goals of MMIS for the next generation nuclear power plant are to improve plant safety and the cost effectiveness of nuclear power plants, and to meet with regulatory requirements. For the optimized design of MMIS, conceptual design bases are required for the optimization of MMIS design to establish the design concepts for NGR MMIS. The conceptual design bases are also required for performing the basic design, and verifying the design. The objectives of this study are establishment of MMIS design bases and the development of next generation MMIS configuration concepts. The MMIS design bases for by adopting MMIS requirements developed in the previous study on next generation reactor evaluation techniques and advanced MMIS technologies. The next generation MMIS design requirements are to be developed based on the device obsolescence problems by applying modern digital technology. This report describes the design concepts for the next generation MMIS. In order to develop the design concepts, new technologies were analyzed, and the characteristics of new advanced MMIS designs were reviewed. In addition, reviewing the advanced design features (ADF) resulted from the 3 rd stage of standardization project, the strategy for the application of the results from these activities are prepared. This report includes the comparison results of the design characteristics of next generation MMIS with those of existing plants, YGN 3 and 4, UCN 3 and 4, and NUPLEX 80+. This report also describes the conceptual MMIS configuration of next generation control room, based on the results from the comparison. The results of this study will be an input for the detailed design guidelines and a regulatory requirements review report for the next generation MMIS design, and provide basis for the basis and detailed design of MMI and I and C for main control room. 1 fig., 1 tab., 46 refs. (Author) .new

Next Generation Life Support Project Status

Science.gov (United States)

Barta, Daniel J.; Chullen, Cinda; Pickering, Karen D.; Cox, Marlon; Towsend, Neil; Campbell, Colin; Flynn, Michael; Wheeler, Raymond

2012-01-01

Next Generation Life Support (NGLS) is one of several technology development projects sponsored by NASA s Game Changing Development Program. The NGLS Project is developing life support technologies (including water recovery and space suit life support technologies) needed for humans to live and work productively in space. NGLS has three project tasks: Variable Oxygen Regulator (VOR), Rapid Cycle Amine (RCA) swing bed, and Alternative Water Processor (AWP). The RCA swing bed and VOR tasks are directed at key technology needs for the Portable Life Support System (PLSS) for an Advanced Extravehicular Mobility Unit, with focus on test article development and integrated testing in an Advanced PLSS in cooperation with the Advanced Extra Vehicular Activity (EVA) Project. An RCA swing-bed provides integrated carbon dioxide removal and humidity control that can be regenerated in real time during an EVA. The VOR technology will significantly increase the number of pressure settings available to the space suit. Current space suit pressure regulators are limited to only two settings whereas the adjustability of the advanced regulator will be nearly continuous. The AWP effort, based on natural biological processes and membrane-based secondary treatment, will result in the development of a system capable of recycling wastewater from sources expected in future exploration missions, including hygiene and laundry water. This paper will provide a status of technology development activities and future plans.

Next generation environment for collaborative research

International Nuclear Information System (INIS)

Collados, D.; Denis, G.; Galvez, P.; Newman, H.

2001-01-01

Collaborative environments supporting point to point and multipoint video-conferencing, document and application sharing across both local and wide area networks, video on demand (broadcast and playback) and interactive text facilities will be a crucial element for the development of the next generation of HEP experiments by geographically dispersed collaborations. The 'Virtual Room Video conferencing System' (VRVS) has been developed since 1995, in order to provide a low cost, bandwidth-efficient, extensible means for video conferencing and remote collaboration over networks within the High Energy and Nuclear Physics communities. The VRVS provides worldwide videoconferencing service and collaborative environment to the research and education communities. VRVS uses the Internet2 and ESnet high-performance networks infrastructure to deploy its Web-based system, which now includes more than 5790 registered hosts running VRVS software in more than 50 different countries. VRVS hosts an average of 100-multipoint videoconference and collaborative sessions worldwide every month. There are around 35 reflectors that manage the traffic flow, at HENP labs and universities in the US and Europe. So far, there are 7 Virtual Rooms for World Wide Conferences (involving more than one continent), and 4 Virtual Rooms each for intra-continental conferences in the US, Europe and Asia. VRVS continues to expand and implement new digital video technologies, including H.323 ITU standard integration, MPEG-2 videoconferencing integration, shared environments, and Quality of Service

Next-Generation Sequencing and Genome Editing in Plant Virology

Directory of Open Access Journals (Sweden)

Ahmed Hadidi

2016-08-01

Full Text Available Next-generation sequencing (NGS has been applied to plant virology since 2009. NGS provides highly efficient, rapid, low cost DNA or RNA high-throughput sequencing of the genomes of plant viruses and viroids and of the specific small RNAs generated during the infection process. These small RNAs, which cover frequently the whole genome of the infectious agent, are 21-24 nt long and are known as vsRNAs for viruses and vd-sRNAs for viroids. NGS has been used in a number of studies in plant virology including, but not limited to, discovery of novel viruses and viroids as well as detection and identification of those pathogens already known, analysis of genome diversity and evolution, and study of pathogen epidemiology. The genome engineering editing method, clustered regularly interspaced short palindromic repeats (CRISPR-Cas9 system has been successfully used recently to engineer resistance to DNA geminiviruses (family, Geminiviridae by targeting different viral genome sequences in infected Nicotiana benthamiana or Arabidopsis plants. The DNA viruses targeted include tomato yellow leaf curl virus and merremia mosaic virus (begomovirus; beet curly top virus and beet severe curly top virus (curtovirus; and bean yellow dwarf virus (mastrevirus. The technique has also been used against the RNA viruses zucchini yellow mosaic virus, papaya ringspot virus and turnip mosaic virus (potyvirus and cucumber vein yellowing virus (ipomovirus, family, Potyviridae by targeting the translation initiation genes eIF4E in cucumber or Arabidopsis plants. From these recent advances of major importance, it is expected that NGS and CRISPR-Cas technologies will play a significant role in the very near future in advancing the field of plant virology and connecting it with other related fields of biology.Keywords: Next-generation sequencing, NGS, plant virology, plant viruses, viroids, resistance to plant viruses by CRISPR-Cas9

Fiber to the home: next generation network

Science.gov (United States)