WorldWideScience

Sample records for providing multiple channels

  1. The Importance of Providing Multiple-Channel Sections in Dredging Activities to Improve Fish Habitat Environments

    Directory of Open Access Journals (Sweden)

    Hung-Pin Chiu

    2016-01-01

    Full Text Available After Typhoon Morakot, dredging engineering was conducted while taking the safety of humans and structures into consideration, but partial stream reaches were formed in the multiple-channel sections in Cishan Stream because of anthropogenic and natural influences. This study mainly explores the distribution of each fish species in both the multiple- and single-channel sections in the Cishan Stream. Parts of the environments did not exhibit significant differences according to a one-way ANOVA comparing the multiple- and single-channel sections, but certain areas of the multiple-channel sections had more diverse habitats. Each fish species was widely distributed by non-metric multidimensional scaling in the multiple-channel sections as compared to those in the single-channel sections. In addition, according to the principal component analysis, each fish species has a preferred environment, and all of them have a wide choice of habitat environments in the multiple-channel sections. Finally, the existence of multiple-channel sections could significantly affect the existence of the fish species under consideration in this study. However, no environmental factors were found to have an influence on fish species in the single-channel sections, with the exception of Rhinogobius nantaiensis. The results show that providing multiple-channel sections in dredging activities could improve fish habitat environments.

  2. Spiking neural P systems with multiple channels.

    Science.gov (United States)

    Peng, Hong; Yang, Jinyu; Wang, Jun; Wang, Tao; Sun, Zhang; Song, Xiaoxiao; Luo, Xiaohui; Huang, Xiangnian

    2017-11-01

    Spiking neural P systems (SNP systems, in short) are a class of distributed parallel computing systems inspired from the neurophysiological behavior of biological spiking neurons. In this paper, we investigate a new variant of SNP systems in which each neuron has one or more synaptic channels, called spiking neural P systems with multiple channels (SNP-MC systems, in short). The spiking rules with channel label are introduced to handle the firing mechanism of neurons, where the channel labels indicate synaptic channels of transmitting the generated spikes. The computation power of SNP-MC systems is investigated. Specifically, we prove that SNP-MC systems are Turing universal as both number generating and number accepting devices. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Multiple-Channel Security Architecture and its Implementation over SSL

    Directory of Open Access Journals (Sweden)

    Song Yong

    2006-01-01

    Full Text Available This paper presents multiple-channel SSL (MC-SSL, an architecture and protocol for protecting client-server communications. In contrast to SSL, which provides a single end-to-end secure channel, MC-SSL enables applications to employ multiple channels, each with its own cipher suite and data-flow direction. Our approach also allows for several partially trusted application proxies. The main advantages of MC-SSL over SSL are (a support for end-to-end security in the presence of partially trusted proxies, and (b selective data protection for achieving computational efficiency important to resource-constrained clients and heavily loaded servers.

  4. Parametric modeling for damped sinusoids from multiple channels

    DEFF Research Database (Denmark)

    Zhou, Zhenhua; So, Hing Cheung; Christensen, Mads Græsbøll

    2013-01-01

    The problem of parametric modeling for noisy damped sinusoidal signals from multiple channels is addressed. Utilizing the shift invariance property of the signal subspace, the number of distinct sinusoidal poles in the multiple channels is first determined. With the estimated number, the distinct...

  5. Optimizing Orthogonal Multiple Access based on Quantized Channel State Information

    CERN Document Server

    Marques, Antonio G; Ramos, Javier

    2009-01-01

    The performance of systems where multiple users communicate over wireless fading links benefits from channel-adaptive allocation of the available resources. Different from most existing approaches that allocate resources based on perfect channel state information, this work optimizes channel scheduling along with per user rate and power loadings over orthogonal fading channels, when both terminals and scheduler rely on quantized channel state information. Channel-adaptive policies are designed to optimize an average transmit-performance criterion subject to average quality of service requirements. While the resultant optimal policy per fading realization shows that the individual rate and power loadings can be obtained separately for each user, the optimal scheduling is slightly more complicated. Specifically, per fading realization each channel is allocated either to a single (winner) user, or, to a small group of winner users whose percentage of shared resources is found by solving a linear program. A singl...

  6. Effective capacity of multiple antenna channels: Correlation and keyhole

    KAUST Repository

    Zhong, Caijun

    2012-01-01

    In this study, the authors derive the effective capacity limits for multiple antenna channels which quantify the maximum achievable rate with consideration of link-layer delay-bound violation probability. Both correlated multiple-input single-output and multiple-input multiple-output keyhole channels are studied. Based on the closed-form exact expressions for the effective capacity of both channels, the authors look into the asymptotic high and low signal-to-noise ratio regimes, and derive simple expressions to gain more insights. The impact of spatial correlation on effective capacity is also characterised with the aid of a majorisation theory result. It is revealed that antenna correlation reduces the effective capacity of the channels and a stringent quality-of-service requirement causes a severe reduction in the effective capacity but can be alleviated by increasing the number of antennas. © 2012 The Institution of Engineering and Technology.

  7. Single transmission line interrogated multiple channel data acquisition system

    Science.gov (United States)

    Fasching, George E.; Keech, Jr., Thomas W.

    1980-01-01

    A single transmission line interrogated multiple channel data acquisition system is provided in which a plurality of remote station/sensor circuits each monitors a specific process variable and each transmits measurement values over a single transmission line to a master interrogating station when addressed by said master interrogating station. Typically, as many as 330 remote stations may be parallel connected to the transmission line which may exceed 7,000 feet. The interrogation rate is typically 330 stations/second. The master interrogating station samples each station according to a shared, charging transmit-receive cycle. All remote station address signals, all data signals from the remote stations/sensors and all power for all of the remote station/sensors are transmitted via a single continuous terminated coaxial cable. A means is provided for periodically and remotely calibrating all remote sensors for zero and span. A provision is available to remotely disconnect any selected sensor station from the main transmission line.

  8. Multiple Parameter Estimation With Quantized Channel Output

    CERN Document Server

    Mezghani, Amine; Nossek, Josef A

    2010-01-01

    We present a general problem formulation for optimal parameter estimation based on quantized observations, with application to antenna array communication and processing (channel estimation, time-of-arrival (TOA) and direction-of-arrival (DOA) estimation). The work is of interest in the case when low resolution A/D-converters (ADCs) have to be used to enable higher sampling rate and to simplify the hardware. An Expectation-Maximization (EM) based algorithm is proposed for solving this problem in a general setting. Besides, we derive the Cramer-Rao Bound (CRB) and discuss the effects of quantization and the optimal choice of the ADC characteristic. Numerical and analytical analysis reveals that reliable estimation may still be possible even when the quantization is very coarse.

  9. Towards the Capacity Region of Multiplicative Linear Operator Broadcast Channels

    CERN Document Server

    Pang, Yimin

    2010-01-01

    Recent research indicates that packet multicasting employing random linear network coding can be regarded as transmitting subspaces as codewords over a linear operator channel (LOC). A LOC is normally viewed as a discrete memoryless unicast subspace channel over a finite field. In this paper we propose the framework of linear operator broadcast channels (LOBCs) and start initial work on determining their capacity region. LOBC correspond to a single-source multiple-recipients network, where every recipient's subchannel is a LOC having its own capacity. Our discussion concerns a class of constant-dimension multiplicative LOBCs (CMLOBCs), whose input subspaces have constant dimension and missing vectors of a subspace constitute the only possible channel interference. We first give a necessary and sufficient condition for a CMLOBC being stochastically degraded. Then we classify weakly and strongly degraded CMLOBCs. By numerically computing capacity regions with an Arimoto-Blahut type algorithm and discussing seve...

  10. Escapes in Hamiltonian systems with multiple exit channels: Part II

    OpenAIRE

    Zotos, Euaggelos E.

    2015-01-01

    We explore the escape dynamics in open Hamiltonian systems with multiple channels of escape continuing the work initiated in Part I. A thorough numerical investigation is conducted distinguishing between trapped (ordered and chaotic) and escaping orbits. The determination of the location of the basins of escape towards the different escape channels and their correlations with the corresponding escape periods of the orbits is undoubtedly an issue of paramount importance. We consider four diffe...

  11. On Buffer-Aided Multiple-Access Relay Channel

    DEFF Research Database (Denmark)

    Liu, Rongkuan; Popovski, Petar; Wang, Gang

    2016-01-01

    This letter treats uplink scenario where M user equipments (UEs) send to a base station (BS), possibly via a common relay station (RS) that is equipped with a buffer. This is a multiple-access relay channel aided by a buffer. We devise a protocol in which the transmission mode is selected...... adaptively, using the buffer at the RS in order to maximize the average system throughput. We consider the general case in which the RS and the BS can have limits on the maximal number of transmitters that can be received over the multiple access channel. In each slot, there are three type possible actions...

  12. Oxidation of multiple methionine residues impairs rapid sodium channel inactivation

    Science.gov (United States)

    Kassmann, Mario; Hansel, Alfred; Leipold, Enrico; Birkenbeil, Jan; Lu, Song-Qing; Hoshi, Toshinori; Heinemann, Stefan H.

    2010-01-01

    Reactive oxygen species (ROS) readily oxidize the sulfur-containing amino acids cysteine and methionine (Met). The impact of Met oxidation on the fast inactivation of the skeletal muscle sodium channel NaV1.4 expressed in human embryonic kidney cells was studied by applying the Met-preferring oxidant chloramine-T (ChT) or by irradiating the ROS-producing dye Lucifer Yellow in the patch pipettes. Both interventions dramatically slowed down inactivation of the sodium channels. Replacement of Met in the Ile-Phe-Met inactivation motif with Leu (M1305L) strongly attenuated the oxidizing effect on inactivation but did not eliminate it completely. Mutagenesis of conserved Met residues in the intracellular linkers connecting the membrane-spanning segments of the channel (M1469L and M1470L) also markedly diminished the oxidation sensitivity of the channel, while that of other conserved Met residues (442, 1139, 1154, 1316) were without any noticeable effect. The results of mutagenesis of results, assays of other NaV channel isoforms (NaV1.2, NaV1.5, NaV1.7) and the kinetics of the oxidation-induced removal of inactivation collectively indicate that multiple Met target residues need to be oxidized to completely impair inactivation. This arrangement using multiple Met residues confers a finely graded oxidative modulation of NaV channels and allows organisms to adapt to a variety of oxidative stress conditions, such as ischemic reperfusion. PMID:18369661

  13. Adaptation of the Electra Radio to Support Multiple Receive Channels

    Science.gov (United States)

    Satorius, Edgar H.; Shah, Biren N.; Bruvold, Kristoffer N.; Bell, David J.

    2011-01-01

    Proposed future Mars missions plan communication between multiple assets (rovers). This paper presents the results of a study carried out to assess the potential adaptation of the Electra radio to a multi-channel transceiver. The basic concept is a Frequency Division multiplexing (FDM) communications scheme wherein different receiver architectures are examined. Options considered include: (1) multiple IF slices, A/D and FPGAs each programmed with an Electra baseband modem; (2) common IF but multiple A/Ds and FPGAs and (3) common IF, single A/D and single or multiple FPGAs programmed to accommodate the FDM signals. These options represent the usual tradeoff between analog and digital complexity. Given the space application, a common IF is preferable; however, multiple users present dynamic range challenges (e.g., near-far constraints) that would favor multiple IF slices (Option 1). Vice versa, with a common IF and multiple A/Ds (Option 2), individual AGC control of the A/Ds would be an important consideration. Option 3 would require a common AGC control strategy and would entail multiple digital down conversion paths within the FPGA. In this paper, both FDM parameters as well as the different Electra design options will be examined. In particular, signal channel spacing as a function of user data rates and transmit powers will be evaluated. In addition, tradeoffs between the different Electra design options will be presented with the ultimate goal of defining an augmented Electra radio architecture for potential future missions.

  14. Minimum Symbol Error Rate Detection in Single-Input Multiple-Output Channels with Markov Noise

    DEFF Research Database (Denmark)

    Christensen, Lars P.B.

    2005-01-01

    Minimum symbol error rate detection in Single-Input Multiple- Output(SIMO) channels with Markov noise is presented. The special case of zero-mean Gauss-Markov noise is examined closer as it only requires knowledge of the second-order moments. In this special case, it is shown that optimal detection...... can be achieved by a Multiple-Input Multiple- Output(MIMO) whitening filter followed by a traditional BCJR algorithm. The Gauss-Markov noise model provides a reasonable approximation for co-channel interference, making it an interesting single-user detector for many multiuser communication systems...

  15. Experimentation of Eigenvector Dynamics in a Multiple Input Multiple Output Channel in the 5GHz Band

    DEFF Research Database (Denmark)

    Brown, Tim; Eggers, Patrick Claus F.; Katz, Marcos

    2005-01-01

    Much research has been carried out on the production of both physical and non physical Multiple Input Multiple Output channel models with regard to increased channel capacity as well as analysis of eigenvalues through the use of singular value decomposition. Little attention has been paid...... to the analysis of vector dynamics in terms of how the state of eigenvectors will change as a mobile is moving through a changing physical environment. This is important in terms of being able to track the orthogonal eigenmodes at system level, while also relieving the burden of tracking of the full channel...

  16. Multiple Access Channels with States Causally Known at Transmitters

    OpenAIRE

    Li, Min; Simeone, Osvaldo; Yener, Aylin

    2010-01-01

    It has been recently shown by Lapidoth and Steinberg that strictly causal state information can be beneficial in multiple access channels (MACs). Specifically, it was proved that the capacity region of a two-user MAC with independent states, each known strictly causally to one encoder, can be enlarged by letting the encoders send compressed past state information to the decoder. In this work, a generalization of the said strategy is proposed whereby the encoders compress also the past transmi...

  17. An algorithm to design a multiple-channel communications system

    Science.gov (United States)

    Nguyen, Tien M.; Gevargiz, John M.; Hinedi, Sami

    1991-01-01

    The authors present a novel algorithm to design a phase-modulated residual carrier communications system for optimum performance. The algorithm has been developed as an aid in the design of two telemetry data channels operating simultaneously with a turn-around ranging signal. The algorithm provides the selection of an optimum subcarrier frequency and modulation indices for minimizing the mutual interferences among the channels to achieve desired link performance margins. The set of modulation indices provided by this algorithm will also achieve an optimum power division between the carrier, the ranging and the high data rate and low data rate channels. Finally, a software program using this algorithm has been developed for use with personal computers. This program provides the computation of the optimum subcarrier frequencies and modulation indices for a standard case that is recommended by the international Consultative Committee for Space Data Systems.

  18. Wireless Energy Harvesting Using Signals from Multiple Fading Channels

    KAUST Repository

    Chen, Yunfei

    2017-08-01

    In this paper, we study the average, the probability density function and the cumulative distribution function of the harvested power. In the study, the signals are transmitted from multiple sources. The channels are assumed to be either Rician fading or Gamma-shadowed Rician fading. The received signals are then harvested by using either a single harvester for simultaneous transmissions or multiple harvesters for transmissions at different frequencies, antennas or time slots. Both linear and nonlinear models for the energy harvester at the receiver are examined. Numerical results are presented to show that, when a large amount of harvested power is required, a single harvester or the linear range of a practical nonlinear harvester are more efficient, to avoid power outage. Further, the power transfer strategy can be optimized for fixed total power. Specifically, for Rayleigh fading, the optimal strategy is to put the total power at the source with the best channel condition and switch off all other sources, while for general Rician fading, the optimum magnitudes and phases of the transmitting waveforms depend on the channel parameters.

  19. Multiple-role dilemmas for military mental health care providers.

    Science.gov (United States)

    Johnson, W Brad; Bacho, Roderick; Heim, Mark; Ralph, John

    2006-04-01

    Military psychologists and psychiatrists frequently face ethical quandaries involving boundary crossings, or extratherapy contact, and multiple relationships. A multiple relationship is defined as necessarily engaging psychotherapy patients in nonclinical roles, such as coworker, superior officer, neighbor, or friend. In contrast to their civilian counterparts, military mental health professionals must often engage patients in many different contexts and roles. In this article, we consider the distinctive features of mental health practice in the military and offer military providers several practice guidelines for avoiding harm to patients in military settings. This article is also designed to enhance sensitivity to multiple-role risks among nonpsychiatric providers.

  20. Multiple Description Coding for Closed Loop Systems over Erasure Channels

    DEFF Research Database (Denmark)

    Østergaard, Jan; Quevedo, Daniel

    2013-01-01

    dropouts and delays, we transmit quantized control vectors containing current control values for the decoder as well as future predicted control values. Second, we utilize multiple description coding based on forward error correction codes to further aid in the robustness towards packet erasures......In this paper, we consider robust source coding in closed-loop systems. In particular, we consider a (possibly) unstable LTI system, which is to be stabilized via a network. The network has random delays and erasures on the data-rate limited (digital) forward channel between the encoder (controller...

  1. On Multiple Users Scheduling Using Superposition Coding over Rayleigh Fading Channels

    KAUST Repository

    Zafar, Ammar

    2013-02-20

    In this letter, numerical results are provided to analyze the gains of multiple users scheduling via superposition coding with successive interference cancellation in comparison with the conventional single user scheduling in Rayleigh blockfading broadcast channels. The information-theoretic optimal power, rate and decoding order allocation for the superposition coding scheme are considered and the corresponding histogram for the optimal number of scheduled users is evaluated. Results show that at optimality there is a high probability that only two or three users are scheduled per channel transmission block. Numerical results for the gains of multiple users scheduling in terms of the long term throughput under hard and proportional fairness as well as for fixed merit weights for the users are also provided. These results show that the performance gain of multiple users scheduling over single user scheduling increases when the total number of users in the network increases, and it can exceed 10% for high number of users

  2. Provider Patient-Sharing Networks and Multiple-Provider Prescribing of Benzodiazepines.

    Science.gov (United States)

    Ong, Mei-Sing; Olson, Karen L; Cami, Aurel; Liu, Chunfu; Tian, Fang; Selvam, Nandini; Mandl, Kenneth D

    2016-02-01

    Prescription benzodiazepine overdose continues to cause significant morbidity and mortality in the US. Multiple-provider prescribing, due to either fragmented care or "doctor-shopping," contributes to the problem. To elucidate the effect of provider professional relationships on multiple-provider prescribing of benzodiazepines, using social network analytics. A retrospective analysis of commercial healthcare claims spanning the years 2008 through 2011. Provider patient-sharing networks were modelled using social network analytics. Care team cohesion was measured using care density, defined as the ratio between the total number of patients shared by provider pairs within a patient's care team and the total number of provider pairs in the care team. Relationships within provider pairs were further quantified using a range of network metrics, including the number and proportion of patients or collaborators shared. The relationship between patient-sharing network metrics and the likelihood of multiple prescribing of benzodiazepines. Patients between the ages of 18 and 64 years who received two or more benzodiazepine prescriptions from multiple providers, with overlapping coverage of more than 14 days. A total of 5659 patients and 1448 provider pairs were included in our study. Among these, 1028 patients (18.2 %) received multiple prescriptions of benzodiazepines, involving 445 provider pairs (30.7 %). Patients whose providers rarely shared patients had a higher risk of being prescribed overlapping benzodiazepines; the median care density was 8.1 for patients who were prescribed overlapping benzodiazepines and 10.1 for those who were not (p benzodiazepines. Our findings demonstrate the importance of care team cohesion in addressing multiple-provider prescribing of controlled substances. Furthermore, we illustrate the potential of the provider network as a surveillance tool to detect and prevent adverse events that could arise due to fragmentation of care.

  3. Modulatory mechanisms and multiple functions of somatodendritic A-type K+ channel auxiliary subunits

    Directory of Open Access Journals (Sweden)

    Henry Hungtao Jerng

    2014-03-01

    Full Text Available Auxiliary subunits are non-conducting, modulatory components of the multi-protein ion channel complexes that underlie normal neuronal signaling. They interact with the pore-forming α-subunits to modulate surface distribution, ion conductance, and channel gating properties. For the somatodendritic subthreshold A-type potassium (ISA channel based on Kv4 α-subunits, two types of auxiliary subunits have been extensively studied: Kv channel-interacting proteins (KChIPs and dipeptidyl peptidase-like proteins (DPLPs. KChIPs are cytoplasmic calcium-binding proteins that interact with intracellular portions of the Kv4 subunits, whereas DPLPs are type II transmembrane proteins that associate with the Kv4 channel core. Both KChIPs and DPLPs genes contain multiple start sites that are used by various neuronal populations to drive the differential expression of functionally distinct N-terminal variants. In turn, these N-terminal variants generate tremendous functional diversity across the nervous system. Here, we focus our review on (1 the molecular mechanism underlying the unique properties of different N-terminal variants, (2 the shaping of native ISA properties by the concerted actions of KChIPs and DPLP variants, and (3 the surprising ways that KChIPs and DPLPs coordinate the activity of multiple channels to fine-tune neuronal excitability. Unlocking the unique contributions of different auxiliary subunit N-terminal variants may provide an important opportunity to develop novel targeted therapeutics to treat numerous neurological disorders.

  4. Equalization and Decoding for Multiple-Input Multiple-Output Wireless Channels

    Directory of Open Access Journals (Sweden)

    Proakis John G

    2002-01-01

    Full Text Available We consider multiple-input, multiple-output (MIMO wireless communication systems that employ multiple transmit and receive antennas to increase the data rate and achieve diversity in fading multipath channels. We begin by focusing on an uncoded system and define optimal and suboptimal receiver structures for this system in Rayleigh fading with and without intersymbol interference. Next, we consider coded MIMO systems. We view the coded system as a serially concatenated convolutional code (SCCC in which the code and the multipath channel take on the roles of constituent codes. This enables us to analyze the performance using the same performance analysis tools as developed previously for SCCCs. Finally, we present an iterative ("turbo" MAP-based equalization and decoding scheme and evaluate its performance when applied to a system with transmit antennas and receive antennas. We show that by performing recursive precoding prior to transmission, significant interleaving gains can be realized compared to systems without precoding.

  5. Channeling consumers to preferred providers and the impact of status quo bias: does type of provider matter?

    Science.gov (United States)

    Boonen, Lieke H H M; Donkers, Bas; Schut, Frederik T

    2011-04-01

    To effectively bargain about the price and quality of health services, health insurers need to successfully channel their enrollees. Little is known about consumer sensitivity to different channeling incentives. In particular, the impact of status quo bias, which is expected to differ between different provider types, can play a large role in insurers' channeling ability. To examine consumer sensitivity to channeling strategies and to analyze the impact of status quo bias for different provider types. With a large-scale discrete choice experiment, we investigate the impact of channeling incentives on choices for pharmacies and general practitioners (GPs). Survey data were obtained among a representative Dutch household panel (n = 2,500). Negative financial incentives have a two to three times larger impact on provider choice than positive ones. Positive financial incentives have a relatively small impact on GP choice, while the impact of qualitative incentives is relatively large. Status quo bias has a large impact on provider choice, which is more prominent in the case of GPs than in the case of pharmacies. The large impact of the status quo bias makes channeling consumers away from their current providers a daunting task, particularly in the case of GPs. © Health Research and Educational Trust.

  6. Semantic distributed resource discovery for multiple resource providers

    NARCIS (Netherlands)

    Pittaras, C.; Ghijsen, M.; Wibisono, A.; Grosso, P.; van der Ham, J.; de Laat, C.

    2012-01-01

    An emerging modus operandi among providers of cloud infrastructures is the one where they share and combine their heterogenous resources to offer end user services tailored to specific scientific and business needs. A challenge to overcome is the discovery of suitable resources among these multiple

  7. On the Secrecy Capacity of the Multiple-Antenna Wiretap Channel with Limited CSI Feedback

    KAUST Repository

    Hyadi, Amal

    2015-12-01

    We study the ergodic secrecy capacity of a block fading wiretap channel when there are multiple antennas at the transmitter, the legitimate receiver and the eavesdropper. We consider that the receivers are aware of their respective channel matrices while the transmitter is only provided by a B-bits feedback of the main channel state information. The feedback bits are sent by the legitimate receiver, at the beginning of each fading block, over an error free public link with limited capacity. Assuming an average transmit power constraint, we provide an upper and a lower bounds on the ergodic secrecy capacity. Then, we present a framework to design the optimal codebooks for feedback and transmission. In addition, we show that the proposed lower and upper bounds coincide asymptotically as the capacity of the feedback link becomes large; hence, fully characterizing the secrecy capacity in this case.

  8. Multiple spatial frequency channels in human visual perceptual memory.

    Science.gov (United States)

    Nemes, V A; Whitaker, D; Heron, J; McKeefry, D J

    2011-12-08

    Current models of short-term visual perceptual memory invoke mechanisms that are closely allied to low-level perceptual discrimination mechanisms. The purpose of this study was to investigate the extent to which human visual perceptual memory for spatial frequency is based upon multiple, spatially tuned channels similar to those found in the earliest stages of visual processing. To this end we measured how performance on a delayed spatial frequency discrimination paradigm was affected by the introduction of interfering or 'memory masking' stimuli of variable spatial frequency during the delay period. Masking stimuli were shown to induce shifts in the points of subjective equality (PSE) when their spatial frequencies were within a bandwidth of 1.2 octaves of the reference spatial frequency. When mask spatial frequencies differed by more than this value, there was no change in the PSE from baseline levels. This selective pattern of masking was observed for different spatial frequencies and demonstrates the existence of multiple, spatially tuned mechanisms in visual perceptual memory. Memory masking effects were also found to occur for horizontal separations of up to 6 deg between the masking and test stimuli and lacked any orientation selectivity. These findings add further support to the view that low-level sensory processing mechanisms form the basis for the retention of spatial frequency information in perceptual memory. However, the broad range of transfer of memory masking effects across spatial location and other dimensions indicates more long range, long duration interactions between spatial frequency channels that are likely to rely contributions from neural processes located in higher visual areas. Copyright © 2011 Elsevier Ltd. All rights reserved.

  9. Modulation frequency discrimination with single and multiple channels in cochlear implant users

    NARCIS (Netherlands)

    Galvin, John J.; Oba, Sandy; Başkent, Deniz; Fu, Qian-Jie

    Temporal envelope cues convey important speech information for cochlear implant (CI) users. Many studies have explored CI users' single-channel temporal envelope processing. However, in clinical Cl speech processors, temporal envelope information is processed by multiple channels. Previous studies

  10. Optimal power allocation of a single transmitter-multiple receivers channel in a cognitive sensor network

    KAUST Repository

    Ayala Solares, Jose Roberto

    2012-08-01

    The optimal transmit power of a wireless sensor network with one transmitter and multiple receivers in a cognitive radio environment while satisfying independent peak, independent average, sum of peak and sum of average transmission rate constraints is derived. A suboptimal scheme is proposed to overcome the frequency of outages for the independent peak transmission rate constraint. In all cases, numerical results are provided for Rayleigh fading channels. © 2012 IEEE.

  11. Price competition and equilibrium analysis in multiple hybrid channel supply chain

    Science.gov (United States)

    Kuang, Guihua; Wang, Aihu; Sha, Jin

    2017-06-01

    The amazing boom of Internet and logistics industry prompts more and more enterprises to sell commodity through multiple channels. Such market conditions make the participants of multiple hybrid channel supply chain compete each other in traditional and direct channel at the same time. This paper builds a two-echelon supply chain model with a single manufacturer and a single retailer who both can choose different channel or channel combination for their own sales, then, discusses the price competition and calculates the equilibrium price under different sales channel selection combinations. Our analysis shows that no matter the manufacturer and retailer choose same or different channel price to compete, the equilibrium price does not necessarily exist the equilibrium price in the multiple hybrid channel supply chain and wholesale price change is not always able to coordinate supply chain completely. We also present the sufficient and necessary conditions for the existence of equilibrium price and coordination wholesale price.

  12. Hydraulic flow through a channel contraction: multiple steady states

    NARCIS (Netherlands)

    Akers, B.; Bokhove, Onno

    2008-01-01

    We have investigated shallow water flows through a channel with a contraction by experimental and theoretical means. The horizontal channel consists of a sluice gate and an upstream channel of constant width $b_0$ ending in a linear contraction of minimum width $b_c$. Experimentally, we observe

  13. Digital Real-Time Multiple Channel Multiple Mode Neutron Flux Estimation on FPGA-based Device

    Directory of Open Access Journals (Sweden)

    Thevenin Mathieu

    2016-01-01

    Full Text Available This paper presents a complete custom full-digital instrumentation device that was designed for real-time neutron flux estimation, especially for nuclear reactor in-core measurement using subminiature Fission Chambers (FCs. Entire fully functional small-footprint design (about 1714 LUTs is implemented on FPGA. It enables real-time acquisition and analysis of multiple channels neutron's flux both in counting mode and Campbelling mode. Experimental results obtained from this brand new device are consistent with simulation results and show good agreement within good uncertainty. This device paves the way for new applications perspectives in real-time nuclear reactor monitoring.

  14. Modeling healthcare data using multiple-channel latent Dirichlet allocation.

    Science.gov (United States)

    Lu, Hsin-Min; Wei, Chih-Ping; Hsiao, Fei-Yuan

    2016-04-01

    Information and communications technologies have enabled healthcare institutions to accumulate large amounts of healthcare data that include diagnoses, medications, and additional contextual information such as patient demographics. To gain a better understanding of big healthcare data and to develop better data-driven clinical decision support systems, we propose a novel multiple-channel latent Dirichlet allocation (MCLDA) approach for modeling diagnoses, medications, and contextual information in healthcare data. The proposed MCLDA model assumes that a latent health status group structure is responsible for the observed co-occurrences among diagnoses, medications, and contextual information. Using a real-world research testbed that includes one million healthcare insurance claim records, we investigate the utility of MCLDA. Our empirical evaluation results suggest that MCLDA is capable of capturing the comorbidity structures and linking them with the distribution of medications. Moreover, MCLDA is able to identify the pairing between diagnoses and medications in a record based on the assigned latent groups. MCLDA can also be employed to predict missing medications or diagnoses given partial records. Our evaluation results also show that, in most cases, MCLDA outperforms alternative methods such as logistic regressions and the k-nearest-neighbor (KNN) model for two prediction tasks, i.e., medication and diagnosis prediction. Thus, MCLDA represents a promising approach to modeling healthcare data for clinical decision support. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Secure Multiple-Antenna Block-Fading Wiretap Channels with Limited CSI Feedback

    KAUST Repository

    Hyadi, Amal

    2017-07-18

    In this paper, we investigate the ergodic secrecy capacity of a block-fading wiretap channel with limited channel knowledge at the transmitter. We consider that the legitimate receiver, the eavesdropper and the transmitter are equipped with multiple antennas and that the receiving nodes are aware of their respective channel matrices. The transmitter, on the other hand, is only provided by a B-bit feedback of the main channel state information. The feedback bits are sent by the legitimate receiver, at the beginning of each fading block, over an error-free public link with limited capacity. The statistics of the main and the eavesdropper channel state information are known at all nodes. Assuming an average transmit power constraint, we establish upper and lower bounds on the ergodic secrecy capacity. Then, we present a framework to design the optimal codebooks for feedback and transmission. In addition, we show that the proposed lower and upper bounds coincide asymptotically as the capacity of the feedback link becomes large, i.e. $B \\ ightarrow \\\\infty$ ; hence, fully characterizing the ergodic secrecy capacity in this case. Besides, we analyze the asymptotic behavior of the presented secrecy rates, at high Signal-to-Noise Ratio (SNR), and evaluate the gap between the bounds.

  16. Channel Estimation and Optimal Power Allocation for a Multiple-Antenna OFDM System

    Directory of Open Access Journals (Sweden)

    Yao Kung

    2002-01-01

    Full Text Available We propose combining channel estimation and optimal power allocation approaches for a multiple-antenna orthogonal frequency division multiplexing (OFDM system in high-speed transmission applications. We develop a least-square channel estimation approach, derive the performance bound of the estimator, and investigate the optimal training sequences for initial channel acquisition. Based on the channel estimates, the optimal power allocation solution which maximizes the bandwidth efficiency is derived under power and quality of service (Qos (symbol error rate constraints. It is shown that combining channel tracking and adaptive power allocation can dramatically enhance the outage capacity of an OFDM multiple-antenna system when severing fading occurs.

  17. Frequency width of open channels in multiple scattering media

    NARCIS (Netherlands)

    Bosch, J.; Goorden, S.A.; Mosk, Allard

    2016-01-01

    We report optical measurements of the spectral width of open transmission channels in a three-dimensional diffusive medium. The light transmission through a sample is enhanced by efficiently coupling to open transmission channels using repeated digital optical phase conjugation. The spectral

  18. A Bayesian Game-Theoretic Approach for Distributed Resource Allocation in Fading Multiple Access Channels

    Directory of Open Access Journals (Sweden)

    Gaoning He

    2010-01-01

    Full Text Available A Bayesian game-theoretic model is developed to design and analyze the resource allocation problem in K-user fading multiple access channels (MACs, where the users are assumed to selfishly maximize their average achievable rates with incomplete information about the fading channel gains. In such a game-theoretic study, the central question is whether a Bayesian equilibrium exists, and if so, whether the network operates efficiently at the equilibrium point. We prove that there exists exactly one Bayesian equilibrium in our game. Furthermore, we study the network sum-rate maximization problem by assuming that the users coordinate according to a symmetric strategy profile. This result also serves as an upper bound for the Bayesian equilibrium. Finally, simulation results are provided to show the network efficiency at the unique Bayesian equilibrium and to compare it with other strategies.

  19. Multiple Scales in the Simulation of Ion Channels and Proteins.

    Science.gov (United States)

    Eisenberg, Bob

    2010-10-21

    Computation of living processes creates great promise for the everyday life of mankind and great challenges for physical scientists. Simulations molecular dynamics have great appeal to biologists as a natural extension of structural biology. Once a biologist sees a structure, she/he wants to see it move. Molecular biology has shown that a small number of atoms, sometimes even one messenger ion, like Ca(2+), can control biological function on the scale of cells, organs, tissues, and organisms. Enormously concentrated ions-at number densities of ~20 M-in protein channels and enzymes are responsible for many of the characteristics of living systems, just as highly concentrated ions near electrodes are responsible for many of the characteristics of electrochemical systems. Here we confront the reality of the scale differences of ions. We show that the scale differences needed to simulate all the atoms of biological cells are 10(7) in linear dimension, 10(21) in three dimensions, 10(9) in resolution, 10(11) in time, and 10(13) in particle number (to deal with concentrations of Ca(2+)). These scales must be dealt with simultaneously if the simulation is to deal with most biological functions. Biological function extends across all of them, all at once in most cases. We suggest a computational approach using explicit multiscale analysis instead of implicit simulation of all scales. The approach is based on an energy variational principle EnVarA introduced by Chun Liu to deal with complex fluids. Variational methods deal automatically with multiple interacting components and scales. When an additional component is added to the system, the resulting Euler Lagrange field equations change form automatically-by algebra alone-without additional unknown parameters. Multifaceted interactions are solutions of the resulting equations. We suggest that ionic solutions should be viewed as complex fluids with simple components. Highly concentrated solutions-dominated by interactions of

  20. Assessing a nephrology-focused YouTube channel's potential to educate health care providers.

    Science.gov (United States)

    Desai, Tejas; Sanghani, Vivek; Fang, Xiangming; Christiano, Cynthia; Ferris, Maria

    2013-01-01

    YouTube has emerged as a potential teaching tool. Studies of the teaching potential of YouTube videos have not addressed health care provider (HCP) satisfaction; a necessary prerequisite for any teaching tool. We conducted a 4-month investigation to determine HCP satisfaction with a nephrology-specific YouTube channel. The Nephrology On-Demand YouTube channel was analyzed from January 1 through April 30, 2011. Sixty-minute nephrology lectures at East Carolina University were compressed into 10-minute videos and uploaded to the channel. HCPs were asked to answer a 5-point Likert questionnaire regarding the accuracy, currency, objectivity and usefulness of the digital format of the teaching videos. Means, standard deviations and 2-sided chi-square testing were performed to analyze responses. Over 80% of HCPs considered the YouTube channel to be accurate, current and objective. A similar percentage considered the digital format useful despite the compression of videos and lack of audio. The nephrology-specific YouTube channel has the potential to educate HCPs of various training backgrounds. Additional studies are required to determine if such specialty-specific channels can improve knowledge acquisition and retention.

  1. Achievable Rate of a Cognitive MIMO Multiple Access Channel With Multi-Secondary Users

    KAUST Repository

    Sboui, Lokman

    2015-03-01

    We study the secondary sum-rate of an underlay cognitive multiple access channel consisting of a primary user and multiple secondary users (SUs) communicating with a common destination. We propose a particular linear precoding and SU selection scheme that maximize the cognitive sum-rate. This scheme is based on space alignment strategy allowing SUs to share the spectrum without interfering with each other. We derive the optimal power allocation for each selected SU after applying perfect or imperfect successive interference cancellation. Numerical results show that the proposed scheme provides a significant sum-rate improvement as the number of SUs increases. In addition, it achieves almost the same performance as an exhaustive search selection, mainly in low and high power ranges. © 1997-2012 IEEE.

  2. Multiple channel secure communication using chaotic system encoding

    Energy Technology Data Exchange (ETDEWEB)

    Miller, S.L.

    1996-12-31

    fA new method to encrypt signals using chaotic systems has been developed that offers benefits over conventional chaotic encryption methods. The method simultaneously encodes multiple plaintext streams using a chaotic system; a key is required to extract the plaintext from the chaotic cipertext. A working prototype demonstrates feasibility of the method by simultaneously encoding and decoding multiple audio signals using electrical circuits.

  3. Appoximation Formula for Estimation of Waiting-Time in Multiple-Channel Queuing Systems

    DEFF Research Database (Denmark)

    Maaløe, Erik

    1973-01-01

    The article deals with two approxiamation formulae for estimation of W, Waiting-times in a M/E/R queuing system.m First is shown how W for the multiple-channel system is approximately an Rth part of the mean waiting time in a single channel system. A second approximation applies the exact ratio...... for W(multi-channel/W(single channel) and M/M/1-systems to general M/Ek/R-systems. This is particularly illustrated in the case og M/M/R and M/D/R-systems as a general warning against general practices...

  4. Low-sampling-rate M-ary multiple access UWB communications in multipath channels

    KAUST Repository

    Alkhodary, Mohammad T.

    2015-08-31

    The desirable characteristics of ultra-wideband (UWB) technology are challenged by formidable sampling frequency, performance degradation in the presence of multi-user interference, and complexity of the receiver due to the channel estimation process. In this paper, a low-rate-sampling technique is used to implement M-ary multiple access UWB communications, in both the detection and channel estimation stages. A novel approach is used for multiple-access-interference (MAI) cancelation for the purpose of channel estimation. Results show reasonable performance of the proposed receiver for different number of users operating many times below Nyquist rate.

  5. Analysis of Coded FHSS Systems with Multiple Access Interference over Generalized Fading Channels

    Directory of Open Access Journals (Sweden)

    Salam A. Zummo

    2009-02-01

    Full Text Available We study the effect of interference on the performance of coded FHSS systems. This is achieved by modeling the physical channel in these systems as a block fading channel. In the derivation of the bit error probability over Nakagami fading channels, we use the exact statistics of the multiple access interference (MAI in FHSS systems. Due to the mathematically intractable expression of the Rician distribution, we use the Gaussian approximation to derive the error probability of coded FHSS over Rician fading channel. The effect of pilot-aided channel estimation is studied for Rician fading channels using the Gaussian approximation. From this, the optimal hopping rate in coded FHSS is approximated. Results show that the performance loss due to interference increases as the hopping rate decreases.

  6. Multiple steadily translating bubbles in a Hele-Shaw channel

    CERN Document Server

    Green, Christopher C

    2013-01-01

    Analytical solutions are constructed for an assembly of any finite number of bubbles in steady motion in a Hele-Shaw channel. The solutions are given in the form of a conformal mapping from a bounded multiply connected circular domain to the flow region exterior to the bubbles. The mapping is written as the sum of two analytic functions---corresponding to the complex potentials in the laboratory and co-moving frames---that map the circular domain onto respective degenerate polygonal domains. These functions are obtained using the generalised Schwarz-Christoffel formula for multiply connected domains in terms of the Schottky-Klein prime function. Our solutions are very general in that no symmetry assumption concerning the geometrical disposition of the bubbles is made. Several examples for various bubble configurations are discussed.

  7. Evaluation of multiple-channel OFDM based airborne ultrasonic communications.

    Science.gov (United States)

    Jiang, Wentao; Wright, William M D

    2016-09-01

    Orthogonal frequency division multiplexing (OFDM) modulation has been extensively used in both wired and wireless communication systems. The use of OFDM technology allows very high spectral efficiency data transmission without using complex equalizers to correct the effect of a frequency-selective channel. This work investigated OFDM methods in an airborne ultrasonic communication system, using commercially available capacitive ultrasonic transducers operating at 50kHz to transmit information through the air. Conventional modulation schemes such as binary phase shift keying (BPSK) and quadrature amplitude modulation (QAM) were used to modulate sub-carrier signals, and the performances were evaluated in an indoor laboratory environment. Line-of-sight (LOS) transmission range up to 11m with no measurable errors was achieved using BPSK at a data rate of 45kb/s and a spectral efficiency of 1b/s/Hz. By implementing a higher order modulation scheme (16-QAM), the system data transfer rate was increased to 180kb/s with a spectral efficiency of 4b/s/Hz at attainable transmission distances up to 6m. Diffraction effects were incorporated into a model of the ultrasonic channel that also accounted for beam spread and attenuation in air. The simulations were a good match to the measured signals and non-LOS signals could be demodulated successfully. The effects of multipath interference were also studied in this work. By adding cyclic prefix (CP) to the OFDM symbols, the bit error rate (BER) performance was significantly improved in a multipath environment. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Channeling Consumers to Preferred Providers and the Impact of Status Quo Bias: Does Type of Provider Matter?

    NARCIS (Netherlands)

    L.H.H.M. Boonen (Lieke); A.C.D. Donkers (Bas); F.T. Schut (Erik)

    2011-01-01

    textabstractContext. To effectively bargain about the price and quality of health services, health insurers need to successfully channel their enrollees. Little is known about consumer sensitivity to different channeling incentives. In particular, the impact of status quo bias, which is expected to

  9. Single-channel mixed signal blind source separation algorithm based on multiple ICA processing

    Science.gov (United States)

    Cheng, Xiefeng; Li, Ji

    2017-01-01

    Take separating the fetal heart sound signal from the mixed signal that get from the electronic stethoscope as the research background, the paper puts forward a single-channel mixed signal blind source separation algorithm based on multiple ICA processing. Firstly, according to the empirical mode decomposition (EMD), the single-channel mixed signal get multiple orthogonal signal components which are processed by ICA. The multiple independent signal components are called independent sub component of the mixed signal. Then by combining with the multiple independent sub component into single-channel mixed signal, the single-channel signal is expanded to multipath signals, which turns the under-determined blind source separation problem into a well-posed blind source separation problem. Further, the estimate signal of source signal is get by doing the ICA processing. Finally, if the separation effect is not very ideal, combined with the last time's separation effect to the single-channel mixed signal, and keep doing the ICA processing for more times until the desired estimated signal of source signal is get. The simulation results show that the algorithm has good separation effect for the single-channel mixed physiological signals.

  10. Concurrent remote management of CPE by multiple service providers

    NARCIS (Netherlands)

    Balemans, H.; Smedt, A. de; Hartog, F.T.H. de; Önnegren, J.

    2006-01-01

    Configuration and management of devices in the home is becoming ever more complex for the user. The trend is, therefore, that it will be performed remotely by network and service providers using dedicated configuration servers. The current remote management architectures do not support an

  11. Generalization of the model-independent Laurent–Pietarinen single-channel pole-extraction formalism to multiple channels

    Energy Technology Data Exchange (ETDEWEB)

    Švarc, Alfred, E-mail: alfred.svarc@irb.hr [Rudjer Bošković Institute, Bijenička cesta 54, P.O. Box 180, 10002 Zagreb (Croatia); Hadžimehmedović, Mirza; Osmanović, Hedim; Stahov, Jugoslav [University of Tuzla, Faculty of Science, Univerzitetska 4, 75000 Tuzla, Bosnia and Herzegovina (Bosnia and Herzegovina); Tiator, Lothar [Institut für Kernphyik, Universität Mainz, D-55099 Mainz (Germany); Workman, Ron L. [Data Analysis Center at the Institute for Nuclear Studies, Department of Physics, The George Washington University, Washington, DC 20052 (United States)

    2016-04-10

    A method to extract resonance pole information from single-channel partial-wave amplitudes based on a Laurent (Mittag-Leffler) expansion and conformal mapping techniques has recently been developed. This method has been applied to a number of reactions and provides a model-independent extraction procedure which is particularly useful in cases where a set of amplitudes is available only at discrete energies. This method has been generalized and applied to the case of a multi-channel fit, where several sets of amplitudes are analyzed simultaneously. The importance of unitarity constraints is discussed. The final result provides a powerful, model-independent tool for analyzing partial-wave amplitudes of coupled or connected channels based entirely on the concepts of analyticity and unitarity.

  12. Measurements of MIMO Indoor Channels at 1800 MHz with Multiple Indoor and Outdoor Base Stations

    Directory of Open Access Journals (Sweden)

    Jaldén Niklas

    2007-01-01

    Full Text Available This paper proposes several configurations for multiple base stations in indoor MIMO systems and compares their performance. The results are based on channel measurements realized with a MIMO testbed. The receiver was moved along several routes and floors on an office building. Both outdoor and indoor locations are considered for the transmitters or base stations, which allow the analysis of not only indoor but also outdoor-to-indoor environment. The use of 2 base stations with different system level combinations of the two is analyzed. We show that the configuration with base station selection provides almost as good performance as a full water-filling scheme when the 2 base stations are placed at different locations. Also the spatial correlation properties for the different configurations are analyzed and the importance of considering path loss when evaluating capacity is highlighted.

  13. Source-Channel Coding Theorems for the Multiple-Access Relay Channe

    CERN Document Server

    Murin, Yonathan; Gündüz, Deniz

    2011-01-01

    Reliable transmission of arbitrarily correlated sources over multiple-access relay channels (MARCs) and multiple-access broadcast relay channels (MABRCs) is considered. In MARCs only the destination is interested in a reconstruction of the sources, while in MABRCs both the relay and the destination want to reconstruct the sources. In addition to arbitrary correlation among the source signals at the users, both the relay and the destination are assumed to have side information correlated with the source signals. Sufficient conditions for reliable communication based on operational separation, as well as necessary conditions on the achievable source-channel rates are characterized. Since operational separation is generally not optimal for MARCs and MABRCs, sufficient conditions for reliable communication using joint source-channel coding schemes based on a combination of the correlation preserving mapping technique with binning are also derived. For correlated sources transmitted over fading Gaussian MARCs and ...

  14. Multiple Faces of the Nostalgia Channel in Russia

    Directory of Open Access Journals (Sweden)

    Ekaterina Kalinina

    2014-06-01

    Full Text Available Through the discourse on nostalgia and media’s role in the production of the content the producers and the audiences created a clear-cut division, stressing that relations to the past become essential markers of their identity in terms of political views. At that, relating to the past with “restorative” nostalgic aspirations, not being selective in the viewed content and not being able to question what was shown in the media, was seen as a sign or consequences of sickness, some kind of pathology, brought into life by inability to adjust to the changing world. At the same time, production of new content, where past is questioned, as well as broadcasting of the content, which previously had been shown on soviet television, were seen as educational practice. In this respect, the Nostalgia channel can be seen both as a sickness and as a remedy. It all depends on the position of the one, who defines what nostalgia is.

  15. Multiple Source Biosimilar Insulin, What's a Provider to Do?

    Science.gov (United States)

    Carter, Alan

    2014-01-01

    In the United States the FDA designates generic products that are bioequivalent as AB substitutable (FDA rating signifying the approved application contains adequate scientific evidence establishing through in vivo and/or in vitro studies the bioequivalence of the product to a selected reference product) and are expected to produce the same therapeutic results as the innovator product. In the case of biological proteins that are similar to already approved innovator biologicals, such as recombinant human insulin, the insulin molecule and accompanying secondary and tertiary structures will differ between manufacturing sources. Even subtle differences between innovator (branded) and alternative "biosimilar" products may produce different therapeutic endpoints. Substitution of a branded insulin with a biosimilar insulin product may result in more, less, or equal therapeutic response making in difficult for the practitioner to assess glycemic control between patient follow-up visits. Significant therapeutic difference is possible, which could result in mild to severe hypoglycemia reaction or hyperglycemia induced tissue damage. Slight molecular changes along with different accompanying proteins, protein fragments, and other naturally occurring contaminants theoretically increase odds of insulin resistance or allergic reaction. Current review of medication product and device quality relies on manufacturer self-oversight and individual reporting of product adverse events after use. While this is usually sufficient for oral medications and many medical devices, critical use products such as sterile products, biosimilar insulin, insulin delivery devices, self-monitoring blood glucose monitoring systems, and test strips require much more vigorous oversight to prevent individual and/or large scale catastrophe. Health care providers should advocate for their patient to have access to affordable, consistent, quality-assured products to effectively and safely manage their

  16. 77 FR 74027 - Certain Integrated Circuit Packages Provided with Multiple Heat-Conducting Paths and Products...

    Science.gov (United States)

    2012-12-12

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Certain Integrated Circuit Packages Provided with Multiple Heat- Conducting Paths and Products... integrated circuit packages provided with multiple heat-conducting paths and products containing same by...

  17. Optimal bit allocation for hybrid scalable/multiple-description video transmission over wireless channels

    Science.gov (United States)

    Jubran, Mohammad K.; Bansal, Manu; Kondi, Lisimachos P.

    2006-01-01

    In this paper, we consider the problem of optimal bit allocation for wireless video transmission over fading channels. We use a newly developed hybrid scalable/multiple-description codec that combines the functionality of both scalable and multiple-description codecs. It produces a base layer and multiple-description enhancement layers. Any of the enhancement layers can be decoded (in a non-hierarchical manner) with the base layer to improve the reconstructed video quality. Two different channel coding schemes (Rate-Compatible Punctured Convolutional (RCPC)/Cyclic Redundancy Check (CRC) coding and, product code Reed Solomon (RS)+RCPC/CRC coding) are used for unequal error protection of the layered bitstream. Optimal allocation of the bitrate between source and channel coding is performed for discrete sets of source coding rates and channel coding rates. Experimental results are presented for a wide range of channel conditions. Also, comparisons with classical scalable coding show the effectiveness of using hybrid scalable/multiple-description coding for wireless transmission.

  18. On the capacity of multiple access and broadcast fading Channels with full channel state information at low power regime

    KAUST Repository

    Rezki, Zouheir

    2013-07-01

    We study the throughput capacity region of the Gaussian multi-access (MAC) fading channel with perfect channel state information (CSI) at the receiver and at the transmitters (CSI-TR), at low power regime. We show that it has a multidimensional rectangle structure and thus is simply characterized by single user capacity points. More specifically, we show that at low power regime, the boundary surface of the capacity region shrinks to a single point corresponding to the sum-rate maximizer and that the coordinates of this point coincide with single user capacity bounds. Using the duality of Gaussian MAC and broadcast channels (BC), we provide a simple characterization of the BC capacity region at low power regime. © 2013 IEEE.

  19. Three-Way Channels With Multiple Unicast Sessions: Capacity Approximation via Network Transformation

    KAUST Repository

    Chaaban, Anas

    2016-09-28

    A network of three nodes mutually communicating with each other is studied. This multi-way network is a suitable model for three-user device-to-device communications. The main goal of this paper is to characterize the capacity region of the underlying Gaussian three-way channel (3WC) within a constant gap. To this end, a capacity outer bound is derived using cut-set bounds and genie-aided bounds. For achievability, the 3WC is first transformed into an equivalent star channel. This latter is then decomposed into a set of “successive” sub-channels, leading to a sub-channel allocation problem. Using backward decoding, interference neutralization, and known results on the capacity of the star-channel relying of physical-layer network coding, an achievable rate region for the 3WC is obtained. It is then shown that the achievable rate region is within a constant gap of the developed outer bound, leading to the desired capacity approximation. Interestingly, in contrast to the Gaussian two-way channel (TWC), adaptation is necessary in the 3WC. Furthermore, message splitting is another ingredient of the developed scheme for the 3WC, which is not required in the TWC. The two setups are, however, similar in terms of their sum-capacity pre-log, which is equal to 2. Finally, some interesting networks and their approximate capacities are recovered as special cases of the 3WC, such as the cooperative broadcast channel and multiple access channel.

  20. On the average complexity of sphere decoding in lattice space-time coded multiple-input multiple-output channel

    KAUST Repository

    Abediseid, Walid

    2012-12-21

    The exact average complexity analysis of the basic sphere decoder for general space-time codes applied to multiple-input multiple-output (MIMO) wireless channel is known to be difficult. In this work, we shed the light on the computational complexity of sphere decoding for the quasi- static, lattice space-time (LAST) coded MIMO channel. Specifically, we drive an upper bound of the tail distribution of the decoder\\'s computational complexity. We show that when the computational complexity exceeds a certain limit, this upper bound becomes dominated by the outage probability achieved by LAST coding and sphere decoding schemes. We then calculate the minimum average computational complexity that is required by the decoder to achieve near optimal performance in terms of the system parameters. Our results indicate that there exists a cut-off rate (multiplexing gain) for which the average complexity remains bounded. Copyright © 2012 John Wiley & Sons, Ltd.

  1. Delay-limited capacity of fading multiple access and broadcast channels in the low power regime

    KAUST Repository

    Rezki, Zouheir

    2015-09-11

    We study delay-limited (also called zero-outage) capacity region of the fading multi-access channel (MAC) with Gaussian noise and perfect channel state information (CSI) at the receiver and at the transmitters (CSI-TR), in the low-power regime. We show that for fading channels where the MAC capacity region is strictly positive, it has a multidimensional rectangle structure and thus is simply characterized by single user capacity points. More specifically, we show that at low power, the boundary surface of the capacity region shrinks to a single point corresponding to the sum-rate maximizer and that the coordinates of this point coincide with single user capacity bounds. Using the duality of the Gaussian MAC and broadcast channels (BC), we show that time-sharing (or time division multiple access (TDMA)) is asymptotically optimal. © 2015 IEEE.

  2. Channel Division Based Multiple Classifiers Fusion for Emotion Recognition Using EEG signals

    Directory of Open Access Journals (Sweden)

    Li Xian

    2017-01-01

    Full Text Available With the rapid development of computer technology, pervasive computing and wearable devices, EEG-based emotion recognition has gradually attracted much attention in affecting computing (AC domain. In this paper, we propose an approach of emotion recognition using EEG signals based on the weighted fusion of multiple base classifiers. These base classifiers based on SVM are constructed using a channel division mechanism according to the neuropsychological theory that different brain areas are differ in processing intensity of emotional information. The outputs of channel base classifiers are integrated by a weighted fusion strategy which is based on the confidence estimation on each emotional label by each base classifier. The evaluation on the DEAP dataset shows that our proposed multiple classifiers fusion method outperforms individual channel base classifiers and the feature fusion method for EEG-based emotion recognition.

  3. Evaluation of Various Feeding Regimens in A Multiple-Batch Cropping System of Channel Catfish Production

    Science.gov (United States)

    A four-year pond study was conducted to compare gross production, feed conversion, processing yield, and body composition of channel catfish Ictalurus punctatus fed once daily or every other day to satiation, or # 110 kg/ha per day in a multiple-batch cropping system. The greatest amount of feed fed...

  4. Variable-length coding for short packets over a multiple access channel with feedback

    DEFF Research Database (Denmark)

    Trillingsgaard, Kasper Fløe; Popovski, Petar

    2014-01-01

    We consider a two-user discrete memoryless multiple access channel with a common stop-feedback signal from the receiver to both transmitters. The achievable regions are characterized using joint decoding and successive cancellation decoding and, it is shown that the achievable regions are signifi...

  5. Multi-channel Dual Clocks three-dimensional probability Random Multiple Access protocol for Wireless Public Bus Networks based on RTS/CTS mechanism

    Directory of Open Access Journals (Sweden)

    Zhou Sheng Jie

    2016-01-01

    Full Text Available A MAC protocol for public bus networks, called Bus MAC protocol, designed to provide high quality Internet service for bus passengers. The paper proposed a multi-channel dual clocks three-demission probability random multiple access protocol based on RTS/CTS mechanism, decreasing collisions caused by multiple access from multiple passengers. Use the RTS/CTS mechanism increases the reliability and stability of the system, reducing the collision possibility of the information packets to a certain extent, improves the channel utilization; use the multi-channel mechanism, not only enables the channel load balancing, but also solves the problem of the hidden terminal and exposed terminal. Use the dual clocks mechanism, reducing the system idle time. At last, the different selection of the three-dimensional probabilities can make the system throughput adapt to the network load which could realize the maximum of the system throughput.

  6. Secret-key agreement over spatially correlated fast-fading multiple-antenna channels with public discussion

    KAUST Repository

    Zorgui, Marwen

    2015-06-14

    We consider secret-key agreement with public discussion over multiple-input multiple-output (MIMO) Rayleigh fast-fading channels under correlated environment. We assume that transmit, legitimate receiver and eavesdropper antennas are correlated. The legitimate receiver and the eavesdropper are assumed to have perfect channel knowledge while the transmitter has only knowledge of the correlation matrices. First, we derive the expression of the secret-key capacity under the considered setup. Then, we prove that the optimal transmit strategy achieving the secret-key capacity consists in transmitting independent Gaussian signals along the eingenvectors of the transmit correlation matrix. The powers allocated to each channel mode are determined as the solution to a numerical optimization problem that we derive. A necessary and sufficient condition for beamforming (i.e., transmitting along the strongest channel mode) to be capacity-achieving is derived. Finally, we analyze the impact of correlation matrices on the system performance and provide closed-form expressions of the gain/loss due to correlation in the high power regime.

  7. On the Ergodic Secret-Key Agreement over Spatially Correlated Multiple-Antenna Channels with Public Discussion

    KAUST Repository

    Zorgui, Marwen

    2015-09-28

    We consider secret-key agreement with public discussion over multiple-input multiple-output (MIMO) Rayleigh fast-fading channels under correlated environment. We assume that transmit, legitimate receiver and eavesdropper antennas are correlated. The legitimate receiver and the eavesdropper are assumed to have perfect channel knowledge while the transmitter has only knowledge of the correlation matrices. First, we derive the expression of the secret-key capacity under the considered setup. We prove that the optimal transmit strategy achieving the secret-key capacity consists in transmitting independent Gaussian signals along the eingenvectors of the transmit correlation matrix. The powers allocated to each channel mode are determined as the solution to a numerical optimization problem. A necessary and sufficient condition for beamforming (i.e., transmitting along the strongest channel mode) to be capacity-achieving is derived. Moreover, we analyze the impact of correlation matrices on the system performance. Finally, we study the system’s performance in the two extreme power regimes. In the high-power regime, we provide closed-form expressions of the gain/loss due to correlation. In the low signal-to-noise ratio (SNR) regime, we investigate the energy efficiency of the system by determining the minimum energy required for sharing a secret-key bit and the wideband slope while highlighting the impact of correlation matrices.

  8. ASIC3 Channels Integrate Agmatine and Multiple Inflammatory Signals through the Nonproton Ligand Sensing Domain

    Directory of Open Access Journals (Sweden)

    Cao Hui

    2010-12-01

    Full Text Available Abstract Background Acid-sensing ion channels (ASICs have long been known to sense extracellular protons and contribute to sensory perception. Peripheral ASIC3 channels represent natural sensors of acidic and inflammatory pain. We recently reported the use of a synthetic compound, 2-guanidine-4-methylquinazoline (GMQ, to identify a novel nonproton sensing domain in the ASIC3 channel, and proposed that, based on its structural similarity with GMQ, the arginine metabolite agmatine (AGM may be an endogenous nonproton ligand for ASIC3 channels. Results Here, we present further evidence for the physiological correlation between AGM and ASIC3. Among arginine metabolites, only AGM and its analog arcaine (ARC activated ASIC3 channels at neutral pH in a sustained manner similar to GMQ. In addition to the homomeric ASIC3 channels, AGM also activated heteromeric ASIC3 plus ASIC1b channels, extending its potential physiological relevance. Importantly, the process of activation by AGM was highly sensitive to mild acidosis, hyperosmolarity, arachidonic acid (AA, lactic acid and reduced extracellular Ca2+. AGM-induced ASIC3 channel activation was not through the chelation of extracellular Ca2+ as occurs with increased lactate, but rather through a direct interaction with the newly identified nonproton ligand sensing domain. Finally, AGM cooperated with the multiple inflammatory signals to cause pain-related behaviors in an ASIC3-dependent manner. Conclusions Nonproton ligand sensing domain might represent a novel mechanism for activation or sensitization of ASIC3 channels underlying inflammatory pain-sensing under in vivo conditions.

  9. Secret-Sharing over Multiple-Antenna Channels with Transmit Correlation

    KAUST Repository

    Zorgui, Marwen

    2015-01-07

    We consider secret-key agreement with public discussion over Rayleigh fastfading channels with transmit correlation. The legitimate receiver and the eavesdropper are assumed to have perfect channel knowledge while the transmitter has only knowledge of the transmit correlation matrix. First, We derive the expression of the key capacity under the considered setup. Then, we show that the optimal transmit strategy achieving the key capacity consists in transmitting Gaussian signals along the eingenvectors of the channel covariance matrix. The powers allocated to each channel mode are determined as the solution of a numerical optimization problem that we derive. We also provide a waterfilling interpretation of the optimal power allocation. Finally, we develop a necessary and sufficient condition for beamforming to be optimal, i.e., transmitting along the strongest channel mode only is key capacity-achieving.

  10. Impact of multiple lymphatic channel drainage to a single nodal basin on outcomes in melanoma.

    Science.gov (United States)

    Wall, James K; Florero, Marilyn; Accortt, Neil A; Allen, Robert; Kashani-Sabet, Mohamed; Morita, Eugene; Leong, Stanley P L

    2007-08-01

    To determine the impact of multiple lymphatic channels (MLCs) on outcome in melanoma. Retrospective cohort study. Academic tertiary care center. Of 1198 consecutive selective sentinel lymphadenectomies performed from 1995 to 2000 for primary invasive melanoma, 502 patients were identified with extremity or truncal melanoma that drained to a single nodal basin. Three cohorts were formed based on lymphatic channels (none, single, and multiple). Tumors with drainage to multiple nodal basins as well as all head and neck tumors were excluded. Multiple variables, including patterns of lymphatic drainage, were analyzed for impact on disease-free and overall survival. Demographics were similar among groups, with a median follow-up of 5.6 years. Univariate analysis revealed MLCs as an independent risk factor for both disease-free (P = .04) and overall survival (P = .003). Multivariate analysis confirmed that tumor depth, sentinel lymph node status, and MLCs were risk factors for both disease-free and overall survival. Kaplan-Meier analysis showed worse survival in the MLCs group. Our study reveals that MLCs are an independent risk factor for recurrence and mortality in melanoma. Multiple lymphatic channels may facilitate the process of metastasis.

  11. Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies.

    Science.gov (United States)

    Mickle, Aaron D; Shepherd, Andrew J; Mohapatra, Durga P

    2016-11-14

    Specialized receptors belonging to the transient receptor potential (TRP) family of ligand-gated ion channels constitute the critical detectors and transducers of pain-causing stimuli. Nociceptive TRP channels are predominantly expressed by distinct subsets of sensory neurons of the peripheral nervous system. Several of these TRP channels are also expressed in neurons of the central nervous system, and in non-neuronal cells that communicate with sensory nerves. Nociceptive TRPs are activated by specific physico-chemical stimuli to provide the excitatory trigger in neurons. In addition, decades of research has identified a large number of immune and neuromodulators as mediators of nociceptive TRP channel activation during injury, inflammatory and other pathological conditions. These findings have led to aggressive targeting of TRP channels for the development of new-generation analgesics. This review summarizes the complex activation and/or modulation of nociceptive TRP channels under pathophysiological conditions, and how these changes underlie acute and chronic pain conditions. Furthermore, development of small-molecule antagonists for several TRP channels as analgesics, and the positive and negative outcomes of these drugs in clinical trials are discussed. Understanding the diverse functional and modulatory properties of nociceptive TRP channels is critical to function-based drug targeting for the development of evidence-based and efficacious new generation analgesics.

  12. Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies

    Directory of Open Access Journals (Sweden)

    Aaron D. Mickle

    2016-11-01

    Full Text Available Specialized receptors belonging to the transient receptor potential (TRP family of ligand-gated ion channels constitute the critical detectors and transducers of pain-causing stimuli. Nociceptive TRP channels are predominantly expressed by distinct subsets of sensory neurons of the peripheral nervous system. Several of these TRP channels are also expressed in neurons of the central nervous system, and in non-neuronal cells that communicate with sensory nerves. Nociceptive TRPs are activated by specific physico-chemical stimuli to provide the excitatory trigger in neurons. In addition, decades of research has identified a large number of immune and neuromodulators as mediators of nociceptive TRP channel activation during injury, inflammatory and other pathological conditions. These findings have led to aggressive targeting of TRP channels for the development of new-generation analgesics. This review summarizes the complex activation and/or modulation of nociceptive TRP channels under pathophysiological conditions, and how these changes underlie acute and chronic pain conditions. Furthermore, development of small-molecule antagonists for several TRP channels as analgesics, and the positive and negative outcomes of these drugs in clinical trials are discussed. Understanding the diverse functional and modulatory properties of nociceptive TRP channels is critical to function-based drug targeting for the development of evidence-based and efficacious new generation analgesics.

  13. Tunable multiple channeled phenomena in graphene-based plasmonic Bragg reflectors

    Science.gov (United States)

    Wang, Jicheng; Shao, Hongyan; Song, Ci; Zheng, Gaige; Hu, Zheng-Da; Sang, Tian

    2017-05-01

    Plasmonic Bragg reflectors based on graphene with multiple channeled phenomena are proposed and investigated numerically. As a mid-infrared waveguide, the monolayer graphene exhibits locally variable optical properties through the modulation of electric fields. The periodical change of the effective refractive index (ERI) on graphene can be determined by applying external gate voltage. When we introduce an unmatched configuration or gate voltage, periodicity is disrupted, and a defect resonance mode is generated. At this point, the structure can be regard as a Fabry-Perot cavity. Accordingly, multiple-channel effects can be achieved by introducing cascaded multiple defects or including double symmetrical Fabry-Perot structures. This design shows applications potential in the graphene-based optoelectronic devices, particularly in the development of low-cost hyperspectral imaging sensors in mid-infrared region.

  14. Fluidic communication between multiple vertically segregated microfluidic channels connected by nanocapillary array membranes.

    Science.gov (United States)

    Gong, Maojun; Flachsbart, Bruce R; Shannon, Mark A; Bohn, Paul W; Sweedler, Jonathan V

    2008-03-01

    Hybrid microfluidic/nanofluidic devices offer unique capabilities for manipulating and analyzing minute volumes of expensive or hard-to-obtain samples. Here, multilayer poly-(methyl methacrylate) microchips, with multiple spatially isolated microfluidic channels interconnected by nanocapillary array membranes (NCAMs), are fabricated using an adhesive contact printing process. The NCAMs, positioned between the microfluidic channel layers, add functionality to the inter-microchannel fluid transfer unit operation. They do so because the transport of specific analytes through the NCAM can be controlled by adjusting the ionic strength, the polarity of the applied bias, the surface charge density, and the pore size. A simplified, floating injection technique for NCAM-coupled nanofluidic devices is described and compared with conventional biased injection. In the floating injection approach, a voltage is applied across the injection channel and the slight electric field extension at the cross-section is used to transfer analytes through the nanopores to the separation channel. Floating injection excels in plug reproducibility, separation resolution, and operation simplicity, although it decreases assay throughput relative to biased injection. Floating injection can avoid the uneven distribution of analytes in the microfluidic channel that sometimes results from biased injection because of the volume mismatch between NCAM nanopore transport capacity and the supply of fluid. Moreover, the pressure-driven flow caused by the mismatch of the EOFs in the microfluidic channels connected by an NCAM must be considered when using NCAMs with pore diameters below 50 nm.

  15. Effects of Voltage-Gated K+ Channel on Cell Proliferation in Multiple Myeloma

    Directory of Open Access Journals (Sweden)

    Wei Wang

    2014-01-01

    Full Text Available Objective. To study the effects and underlying mechanisms of voltage-gated K+ channels on the proliferation of multiple myeloma cells. Methods. RPMI-8226 MM cell line was used for the experiments. Voltage-gated K+ currents and the resting potential were recorded by whole-cell patch-clamp technique. RT-PCR detected Kv channel mRNA expression. Cell viability was analyzed with MTT assay. Cell counting system was employed to monitor cell proliferation. DNA contents and cell volume were analyzed by flow cytometry. Results. Currents recorded in RPMI-8226 cells were confirmed to be voltage-gated K+ channels. A high level of Kv1.3 mRNA was detected but no Kv3.1 mRNA was detected in RPMI-8226 cells. Voltage-gated K+ channel blocker 4-aminopyridine (4-AP (2 mM depolarized the resting potential from −42 ± 1.7 mV to −31.8 ± 2.8 mV (P0.05. Conclusions. In RPMI-8226, voltage-gated K+ channels are involved in proliferation and cell cycle progression its influence on the resting potential and cell volume may be responsible for this process; the inhibitory effect of the voltage-gated K+ channel blocker on RPMI-8226 cell proliferation is a phase-specific event.

  16. On the multiple roles of the voltage gated sodium channel β1 subunit in genetic diseases

    Directory of Open Access Journals (Sweden)

    Debora eBaroni

    2015-05-01

    Full Text Available Voltage-gated sodium channels are intrinsic plasma membrane proteins that initiate the action potential in electrically excitable cells. They are composed of a pore-forming α-subunit and associated β-subunits. The β1-subunit was the first accessory subunit to be cloned. It can be important for controlling cell excitability and modulating multiple aspects of sodium channel physiology. Mutations of β1 are implicated in a wide variety of inherited pathologies, including epilepsy and cardiac conduction diseases. This review summarizes β1-subunit related channelopathies pointing out the current knowledge concerning their genetic background and their underlying molecular mechanisms.

  17. Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals

    Directory of Open Access Journals (Sweden)

    Gasser Andreas

    2010-11-01

    Full Text Available Abstract Background Nociception requires transduction and impulse electrogenesis in nerve fibers which innervate the body surface, including the skin. However, the molecular substrates for transduction and action potential initiation in nociceptors are incompletely understood. In this study, we examined the expression and distribution of Na+/Ca2+ exchanger (NCX and voltage-gated sodium channel isoforms in intra-epidermal free nerve terminals. Results Small diameter DRG neurons exhibited robust NCX2, but not NCX1 or NCX3 immunolabeling, and virtually all PGP 9.5-positive intra-epidermal free nerve terminals displayed NCX2 immunoreactivity. Sodium channel NaV1.1 was not detectable in free nerve endings. In contrast, the majority of nerve terminals displayed detectable levels of expression of NaV1.6, NaV1.7, NaV1.8 and NaV1.9. Sodium channel immunoreactivity in the free nerve endings extended from the dermal boundary to the terminal tip. A similar pattern of NCX and sodium channel immunolabeling was observed in DRG neurons in vitro. Conclusions NCX2, as well as NaV1.6, NaV1.7, NaV1.8 and NaV1.9, are present in most intra-epidermal free nerve endings. The presence of NCX2, together with multiple sodium channel isoforms, in free nerve endings may have important functional implications.

  18. Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals.

    Science.gov (United States)

    Persson, Anna-Karin; Black, Joel A; Gasser, Andreas; Cheng, Xiaoyang; Fischer, Tanya Z; Waxman, Stephen G

    2010-11-30

    Nociception requires transduction and impulse electrogenesis in nerve fibers which innervate the body surface, including the skin. However, the molecular substrates for transduction and action potential initiation in nociceptors are incompletely understood. In this study, we examined the expression and distribution of Na+/Ca2+ exchanger (NCX) and voltage-gated sodium channel isoforms in intra-epidermal free nerve terminals. Small diameter DRG neurons exhibited robust NCX2, but not NCX1 or NCX3 immunolabeling, and virtually all PGP 9.5-positive intra-epidermal free nerve terminals displayed NCX2 immunoreactivity. Sodium channel NaV1.1 was not detectable in free nerve endings. In contrast, the majority of nerve terminals displayed detectable levels of expression of NaV1.6, NaV1.7, NaV1.8 and NaV1.9. Sodium channel immunoreactivity in the free nerve endings extended from the dermal boundary to the terminal tip. A similar pattern of NCX and sodium channel immunolabeling was observed in DRG neurons in vitro. NCX2, as well as NaV1.6, NaV1.7, NaV1.8 and NaV1.9, are present in most intra-epidermal free nerve endings. The presence of NCX2, together with multiple sodium channel isoforms, in free nerve endings may have important functional implications.

  19. 77 FR 39735 - Certain Integrated Circuit Packages Provided With Multiple Heat-Conducting Paths and Products...

    Science.gov (United States)

    2012-07-05

    ... Integrated Circuit Packages Provided With Multiple Heat- Conducting Paths and Products Containing Same... within the United States after importation of certain integrated circuit packages provided with multiple... importation, or the sale within the United States after importation of certain integrated circuit packages...

  20. On Low-Complexity Full-diversity Detection In Multi-User MIMO Multiple-Access Channels

    KAUST Repository

    Ismail, Amr

    2014-01-28

    Multiple-input multiple-output (MIMO) techniques are becoming commonplace in recent wireless communication standards. This newly introduced dimension (i.e., space) can be efficiently used to mitigate the interference in the multi-user MIMO context. In this paper, we focus on the uplink of a MIMO multiple access channel (MAC) where perfect channel state information (CSI) is only available at the destination. We provide new sufficient conditions for a wide range of space-time block codes (STBC)s to achieve full-diversity under partial interference cancellation group decoding (PICGD) with or without successive interference cancellation (SIC) for completely blind users. Interference cancellation (IC) schemes for two and three users are then provided and shown to satisfy the full-diversity criteria. Beside the complexity reduction due to the fact that PICGD enables separate decoding of distinct users without sacrificing the diversity gain, further reduction of the decoding complexity may be obtained. In fact, thanks to the structure of the proposed schemes, the real and imaginary parts of each user\\'s symbols may be decoupled without any loss of performance. Our new IC scheme is shown to outperform recently proposed two-user IC scheme especially for high spectral efficiency while requiring significantly less decoding complexity.

  1. Correlation functions with fusion-channel multiplicity in W{sub 3} Toda field theory

    Energy Technology Data Exchange (ETDEWEB)

    Belavin, Vladimir [I.E. Tamm Department of Theoretical Physics, P.N. Lebedev Physical Institute,Leninsky Avenue 53, 119991 Moscow (Russian Federation); Department of Quantum Physics, Institute for Information Transmission Problems,Bolshoy Karetny per. 19, 127994 Moscow (Russian Federation); Estienne, Benoit [LPTHE, CNRS and Université Pierre et Marie Curie,Sorbonne Universités, 4 Place Jussieu, 75252 Paris Cedex 05 (France); Foda, Omar [School of Mathematics and Statistics, University of Melbourne,Parkville, Victoria 3010 (Australia); Santachiara, Raoul [LPTMS, CNRS (UMR 8626), Université Paris-Saclay,15 rue Georges Clémenceau, 91405 Orsay (France)

    2016-06-22

    Current studies of W{sub N} Toda field theory focus on correlation functions such that the W{sub N} highest-weight representations in the fusion channels are multiplicity-free. In this work, we study W{sub 3} Toda 4-point functions with multiplicity in the fusion channel. The conformal blocks of these 4-point functions involve matrix elements of a fully-degenerate primary field with a highest-weight in the adjoint representation of sl{sub 3}, and a fully-degenerate primary field with a highest-weight in the fundamental representation of sl{sub 3}. We show that, when the fusion rules do not involve multiplicities, the matrix elements of the fully-degenerate adjoint field, between two arbitrary descendant states, can be computed explicitly, on equal footing with the matrix elements of the semi-degenerate fundamental field. Using null-state conditions, we obtain a fourth-order Fuchsian differential equation for the conformal blocks. Using Okubo theory, we show that, due to the presence of multiplicities, this differential equation belongs to a class of Fuchsian equations that is different from those that have appeared so far in W{sub N} theories. We solve this equation, compute its monodromy group, and construct the monodromy-invariant correlation functions. This computation shows in detail how the ambiguities that are caused by the presence of multiplicities are fixed by requiring monodromy-invariance.

  2. Ergodic channel capacity of spatial correlated multiple-input multiple-output free space optical links using multipulse pulse-position modulation

    Science.gov (United States)

    Wang, Huiqin; Wang, Xue; Cao, Minghua

    2017-02-01

    The spatial correlation extensively exists in the multiple-input multiple-output (MIMO) free space optical (FSO) communication systems due to the channel fading and the antenna space limitation. Wilkinson's method was utilized to investigate the impact of spatial correlation on the MIMO FSO communication system employing multipulse pulse-position modulation. Simulation results show that the existence of spatial correlation reduces the ergodic channel capacity, and the reception diversity is more competent to resist this kind of performance degradation.

  3. Phase unwinding for dictionary compression with multiple channel transmission in magnetic resonance fingerprinting.

    Science.gov (United States)

    Lattanzi, Riccardo; Zhang, Bei; Knoll, Florian; Assländer, Jakob; Cloos, Martijn A

    2017-12-24

    Magnetic Resonance Fingerprinting reconstructions can become computationally intractable with multiple transmit channels, if the B 1 + phases are included in the dictionary. We describe a general method that allows to omit the transmit phases. We show that this enables straightforward implementation of dictionary compression to further reduce the problem dimensionality. We merged the raw data of each RF source into a single k-space dataset, extracted the transceiver phases from the corresponding reconstructed images and used them to unwind the phase in each time frame. All phase-unwound time frames were combined in a single set before performing SVD-based compression. We conducted synthetic, phantom and in-vivo experiments to demonstrate the feasibility of SVD-based compression in the case of two-channel transmission. Unwinding the phases before SVD-based compression yielded artifact-free parameter maps. For fully sampled acquisitions, parameters were accurate with as few as 6 compressed time frames. SVD-based compression performed well in-vivo with highly under-sampled acquisitions using 16 compressed time frames, which reduced reconstruction time from 750 to 25min. Our method reduces the dimensions of the dictionary atoms and enables to implement any fingerprint compression strategy in the case of multiple transmit channels. Copyright © 2018 Elsevier Inc. All rights reserved.

  4. Multiple-photon disambiguation on stripline-anode Micro-Channel Plates

    Energy Technology Data Exchange (ETDEWEB)

    Jocher, Glenn R., E-mail: glenn.jocher@ultralytics.com [Ultralytics LLC, Arlington, VA 22203 (United States); Wetstein, Matthew J., E-mail: mwetstein@uchicago.edu [Iowa State University, Department of Physics and Astronomy, 12 Physics Hall, Ames, IA 50011 (United States); Adams, Bernhard, E-mail: badams@incomusa.com [Incom, Inc., 294 Southbridge Road, Charlton, MA 01507 (United States); Nishimura, Kurtis, E-mail: kurtis.nishimura@ultralytics.com [Ultralytics LLC, Arlington, VA 22203 (United States); Usman, Shawn M., E-mail: shawn.usman@nga.mil [Research Directorate, National Geospatial-Intelligence Agency, 7500 GEOINT Dr., Springfield, VA 22150 (United States); Department of Geography and Geoinformation Science, George Mason University, Fairfax, VA 22030 (United States)

    2016-06-21

    Large-Area Picosecond Photo-Detectors (LAPPDs) show great potential for expanding the performance envelope of Micro-Channel Plates (MCPs) to areas of up to 20×20 cm and larger. Such scaling introduces new challenges, including how to meet the electronics readout burden of ever larger area MCPs. One solution is to replace the traditional grid anode used for readout with a microwave stripline anode, thus allowing the channel count to scale with MCP width rather than area. However, stripline anodes introduce new issues not commonly dealt with in grid-anodes, especially as their length increases. One of these issues is the near simultaneous arrival of multiple photons on the detector, creating possible confusion about how to reconstruct their arrival times and positions. We propose a maximum a posteriori solution to the problem and verify its performance in simulated scintillator and water-Cherenkov detectors.

  5. Multiple-photon disambiguation on stripline-anode Micro-Channel Plates

    Science.gov (United States)

    Jocher, Glenn R.; Wetstein, Matthew J.; Adams, Bernhard; Nishimura, Kurtis; Usman, Shawn M.

    2016-06-01

    Large-Area Picosecond Photo-Detectors (LAPPDs) show great potential for expanding the performance envelope of Micro-Channel Plates (MCPs) to areas of up to 20×20 cm and larger. Such scaling introduces new challenges, including how to meet the electronics readout burden of ever larger area MCPs. One solution is to replace the traditional grid anode used for readout with a microwave stripline anode, thus allowing the channel count to scale with MCP width rather than area. However, stripline anodes introduce new issues not commonly dealt with in grid-anodes, especially as their length increases. One of these issues is the near simultaneous arrival of multiple photons on the detector, creating possible confusion about how to reconstruct their arrival times and positions. We propose a maximum a posteriori solution to the problem and verify its performance in simulated scintillator and water-Cherenkov detectors.

  6. Single sensor for multiple analytes in different optical channel: Applying for multi-ion response modulation

    Science.gov (United States)

    Liang, Chunshuang; Jiang, Shimei

    2017-08-01

    A Schiff-base, (2,4-di-tert-butyl-6-((2-hydroxyphenyl-imino)-methyl)phenol) (L), has been improved to function as a simultaneous multi-ion probe in different optical channel. The probe changes from colorless to orangish upon being deprotonated by F-, while the presence of Al3+ significantly enhances the fluorescence of the probe due to the inhibition of Cdbnd N isomerization, cation-induced inhibition of excited-state intramolecular proton transfer (ESIPT), and chelation enhanced fluorescence (CHEF). Dual-channel ;off-on; switching behavior resulted from the sequential input of F- and Al3+, reflecting the balance of independent reactions of Al3+ and F- with L and with one another. This sensing phenomenon realizes transformation between multiple states and beautifully mimics a ;Write-Read-Erase-Read; logic circuit with two feedback loops.

  7. Theoretical analysis and simulation of a code division multiple access system (cdma for secure signal transmission in wideband channels

    Directory of Open Access Journals (Sweden)

    Stevan M. Berber

    2014-06-01

    Code Division Multiple Access (CDMA technique which allows communications of multiple users in the same communication system. This is achieved in such a way that each user is assigned a unique code sequence, which is used at the receiver side to discover the information dedicated to that user. These systems belong to the group of communication systems for direct sequence spread spectrum systems. Traditionally, CDMA systems use binary orthogonal spreading codes. In this paper, a mathematical model and simulation of a CDMA system based on the application of non-binary, precisely speaking, chaotic spreading sequences. In their nature, these sequences belong to random sequences with infinite periodicity, and due to that they are appropriate for applications in the systems that provide enhanced security against interception and secrecy in signal transmission. Numerous papers are dedicated to the development of CDMA systems in flat fading channels. This paper presents the results of these systems analysis for the case when frequency selective fading is present in the channel. In addition, the paper investigates a possibility of using interleaving techniques to mitigate fading in a wideband channel with the frequency selective fading. Basic structure of a CDMA communication system and its operation In this paper, a CDMA system block schematic is ppresented and the function of all blocks is explained. Notation  to be used in the paper is introduced. Chaotic sequences are defined and explained in accordance with the method of their generation. A wideband channel with frequency selective fading is defined by its impulse response function. Theoretical analysis of a CDMA system with flat fading in a narrowband channel A narrowband channel and flat fading are defined. A mathematical analysis of the system is conducted by presenting the signal expressions at vital points in the transmitter and receiver. The expression of the signal at the output of the sequence correlator is

  8. The channel catfish genome sequence provides insights into the evolution of scale formation in teleosts

    Science.gov (United States)

    Channel catfish (Ictalurus punctatus), characteristic of its scaleless skin and prominent barbels, is an ideal species to study osteogenesis, development of appendages, olfactory sensing, and immunological adaptation. It is the leading aquaculture species in the United States. A high quality refere...

  9. A Change in the Ion Selectivity of Ligand-Gated Ion Channels Provides a Mechanism to Switch Behavior.

    Directory of Open Access Journals (Sweden)

    Jennifer K Pirri

    Full Text Available Behavioral output of neural networks depends on a delicate balance between excitatory and inhibitory synaptic connections. However, it is not known whether network formation and stability is constrained by the sign of synaptic connections between neurons within the network. Here we show that switching the sign of a synapse within a neural circuit can reverse the behavioral output. The inhibitory tyramine-gated chloride channel, LGC-55, induces head relaxation and inhibits forward locomotion during the Caenorhabditis elegans escape response. We switched the ion selectivity of an inhibitory LGC-55 anion channel to an excitatory LGC-55 cation channel. The engineered cation channel is properly trafficked in the native neural circuit and results in behavioral responses that are opposite to those produced by activation of the LGC-55 anion channel. Our findings indicate that switches in ion selectivity of ligand-gated ion channels (LGICs do not affect network connectivity or stability and may provide an evolutionary and a synthetic mechanism to change behavior.

  10. Effect of wall-mounted obstacles on mixed convection heat transfer in an open channel with multiple discrete heaters

    Science.gov (United States)

    Rafi, Araf Al; Anik, Rahagir Ridwan; Sarah, Anika

    2017-12-01

    In this study a numerical investigation on two dimensional laminar steady mixed convection has been carried out in an open channel with upper wall mounted with obstacles and the lower wall is provided with different types of protruding multiple discrete heaters. The upper wall is maintained at constant low temperature. All obstacles are isotherm and have the same temperature as the walls. The heaters are also connected with adiabatic segments and the heater surfaces are assumed to release heat at constant heat flux. At inlet, a uniform velocity profile has been induced. To avoid discontinuity, the temperature of the incoming stream is supposed to change linearly. The working fluid used in this study is air and Boussinesq approximation has been applied for fluid having constant properties. Finite element method has been used to solve the non-dimensionalised governing equations of conservation of mass, momentum, and energy along with the boundary conditions. Effect of various parameters such as Reynolds number (Re), Grashof number(Gr) and Richardson number (Ri) on temperature distribution, flow patterns and heat transfer rate has been studied. The results show that increasing the Reynolds number while keeping Ri=1 gives better cooling performance. It has been observed that the wall-mounted obstacles over the channel wall, increases the Nusselt number when compared to the simple channel.

  11. A Multi-channel Multiple Access Scheme Using Frequency Offsets - Modelling and Analysis

    NARCIS (Netherlands)

    Morshed, S.; Baratchi, Mitra; Mandal, Pranab K.; Heijenk, Geert

    2016-01-01

    A system using frequency offset based transmit- reference (TR) modulation allows multiple nodes to transmit simultaneously and asynchronously without any mutual timing coordination. Thus, such a system provides inherent capabilities for a multiple access in the medium access control (MAC) layer to

  12. Capacity Bounds for the Gaussian IM-DD Optical Multiple-Access Channel

    KAUST Repository

    Chaaban, Anas

    2017-03-18

    Optical wireless communications (OWC) is a promising technology for closing the mismatch between the growing number of connected devices and the limited wireless network capabilities. Similar to downlink, uplink can also benefit from OWC for establishing connectivity between such devices and an optical access point. In this context, the incoherent intensitymodulation and direct-detection (IM-DD) scheme is desirable in practice. Hence, it is important to understand the fundamental limits of communication rates over an OWC uplink employing IM-DD, i.e., the channel capacity. This uplink, modeled as a Gaussian multiple-access channel (MAC) for indoors OWC, is studied in this paper, under the IM-DD constraints which form the main difference with the standard Gaussian MAC commonly studied in the radio-frequency context. Capacity region outer and inner bounds for this channel are derived. The bounds are fairly close at high signal-to-noise ratio (SNR), where a truncated- Gaussian input distribution achieves the capacity region within a constant gap. Furthermore, the bounds coincide at low SNR showing the optimality of on-off keying combined with successive cancellation decoding in this regime. At moderate SNR, an optimized uniformly-spaced discrete input distribution achieves fairly good performance.

  13. On the Tradeoff Between Multiuser Diversity and Training Overhead in Multiple Access Channels

    CERN Document Server

    Scarlett, Jonathan; Dey, Subhrakanti

    2011-01-01

    We consider a single antenna narrowband multiple access channel with a large number of users, in which training sequences are sent to the base station one at a time and the user estimated to be the strongest is scheduled to transmit. In such a system, there is an inherent trade-off between training overhead and the amount of multiuser diversity achieved. Considering a lower bound on the ergodic sum capacity with channel uncertainty under an average total power constraint, we optimize the length of the training sequences, average transmit power during training, and number of users K considered for transmission in each coherence block. Assuming a block fading model with block length L and independent Rayleigh distributed channel gains, we derive closed form expressions for the optimal proportion of both time and power spent on training in terms of K and L. Considering the behavior of the system as L grows large, we derive second order expressions for each of the optimal parameters in terms of L, as well as the ...

  14. On the capacity of multiple access and broadcast fading channels with full channel state information at low SNR

    KAUST Repository

    Rezki, Zouheir

    2014-01-01

    We study the throughput capacity region of the Gaussian multi-access (MAC) fading channel with perfect channel state information (CSI) at the receiver and at the transmitters, at low power regime. We show that it has a multidimensional rectangle structure and thus is simply characterized by single user capacity points.More specifically, we show that at low power regime, the boundary surface of the capacity region shrinks to a single point corresponding to the sum rate maximizer and that the coordinates of this point coincide with single user capacity bounds. Inspired from this result, we propose an on-off scheme, compute its achievable rate, and show that this scheme achieves single user capacity bounds of the MAC channel for a wide class of fading channels at asymptotically low power regime. We argue that this class of fading encompasses all known wireless channels for which the capacity region of the MAC channel has even a simpler expression in terms of users\\' average power constraints only. Using the duality of Gaussian MAC and broadcast channels (BC), we deduce a simple characterization of the BC capacity region at low power regime and show that for a class of fading channels (including Rayleigh fading), time-sharing is asymptotically optimal. © 2014 IEEE.

  15. Family Members Providing Home-Based Palliative Care to Older Adults: The Enactment of Multiple Roles

    Science.gov (United States)

    Clemmer, Sarah J.; Ward-Griffin, Catherine; Forbes, Dorothy

    2008-01-01

    Canadians are experiencing increased life expectancy and chronic illness requiring end-of-life care. There is limited research on the multiple roles for family members providing home-based palliative care. Based on a larger ethnographic study of client-family-provider relationships in home-based palliative care, this qualitative secondary analysis…

  16. Simultaneous multiple DWDM channel NRZ-to-RZ regenerative format conversion at 10 and 20 Gb/s.

    Science.gov (United States)

    Yu, Yu; Zhang, Xinliang; Rosas-Fernández, Jose B; Huang, Dexiu; Penty, Richard V; White, Ian H

    2009-03-02

    We propose and demonstrate simultaneous optoelectronic NRZ-to-RZ regenerative format conversion for multiple DWDM channels using a single phase modulator (PM) and a fibre delay-interferometer (DI). In order to accommodate multiple DWDM channels, the DI is designed to have a free spectral range (FSR) equal to the channel spacing. This thus extracts the chirp induced by the phase modulation for all the channels at the same time. Since the original carriers are suppressed to some extent, the NRZ-to-RZ conversions can be achieved with regeneration. Multi-channel format conversion is successfully demonstrated for 16 channels at 10 Gb/s and 8 channels at 20 Gb/s, with a channel spacing of 100 GHz. Bit error ratio (BER) measurements at 10 Gb/s show 3.5 and 4.2 dB penalty improvements for 50 and 75 km transmission without dispersion compensation, respectively. Significant extinction ratio (ER) improvement and timing jitter reduction is observed for the converted channels.

  17. New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1

    DEFF Research Database (Denmark)

    Korolkova, Yuliya V; Bocharov, Eduard V; Angelo, Kamilla

    2002-01-01

    resolved by NMR consists of a short alpha-helix and a triple-stranded antiparallel beta-sheet. By toxin mutagenesis study we identified the residues that are important for the binding of BeKm-1 to the human ERG K+ (HERG) channel. The most critical residues (Tyr-11, Lys-18, Arg-20, Lys-23) are located...... in the alpha-helix and following loop whereas the "traditional" functional site of other short scorpion toxins is formed by residues from the beta-sheet. Thus the unique location of the binding site of BeKm-1 provides its specificity toward the HERG channel....

  18. Parity-Check Network Coding for Multiple Access Relay Channel in Wireless Sensor Cooperative Communications

    Directory of Open Access Journals (Sweden)

    Du Bing

    2010-01-01

    Full Text Available A recently developed theory suggests that network coding is a generalization of source coding and channel coding and thus yields a significant performance improvement in terms of throughput and spatial diversity. This paper proposes a cooperative design of a parity-check network coding scheme in the context of a two-source multiple access relay channel (MARC model, a common compact model in hierarchical wireless sensor networks (WSNs. The scheme uses Low-Density Parity-Check (LDPC as the surrogate to build up a layered structure which encapsulates the multiple constituent LDPC codes in the source and relay nodes. Specifically, the relay node decodes the messages from two sources, which are used to generate extra parity-check bits by a random network coding procedure to fill up the rate gap between Source-Relay and Source-Destination transmissions. Then, we derived the key algebraic relationships among multidimensional LDPC constituent codes as one of the constraints for code profile optimization. These extra check bits are sent to the destination to realize a cooperative diversity as well as to approach MARC decode-and-forward (DF capacity.

  19. Development of multiple calcium channel types in cultured mouse hippocampal neurons.

    Science.gov (United States)

    Chameau, P; Lucas, P; Melliti, K; Bournaud, R; Shimahara, T

    1999-05-01

    The development of multiple calcium channel activities was studied in mouse hippocampal neurons in culture, using the patch-clamp technique. A depolarizing pulse (40-50 ms duration) from the holding potential of -80 mV to levels more depolarized than -40 mV produced a low threshold T-type current. The T-type current was observed in 52% of four days in vitro neurons. The number of neurons which expressed T-type current decreased with age of culture, so that the current was detected in only 18% of neurons after 16 days in vitro. The T-type current densities varied between 1.9 pA/pF and 3.29 pA/pF in the mean values during the period studied (4-16 days in vitro). A depolarizing pulse from -80 mV to levels more depolarized than -35 mV evoked a high threshold calcium channel current. The high threshold current density increased in the mean values from 3.9 pA/pF in four days in vitro neurons to 28 pA/pF in 16 days in vitro neurons. We have then examined the effect of nifedipine, omega-Agatoxin IVA and omega-conotoxin GVIA on the high threshold current. Nifedipine (1-5 microM) sensitive current density stayed in the range of 1.9-2.1 pA/pF during 4-16 days in vitro, while omega-Agatoxin IVA (200 nM) sensitive current density increased in the mean values from 1.54 pA/pF in four days in vitro neurons to 21.5 pA/pF in 16 days in vitro neurons. The omega-conotoxin GVIA sensitive N-type channel current was maximum at eight days in vitro (5.44 pA/pF) and it reduced progressively to reach almost half (2.46 pA/pF) in 16 days in vitro neurons. These results showed that diverse subtypes of calcium channels change in density during the early period of culture. We suggest that the temporal expression of each type of channel may be linked to the development of neural activities.

  20. A Team Study of a Multiple-Power Wireless Random Channel Access Mechanism with Capture Effect

    Directory of Open Access Journals (Sweden)

    Abdelillah Karouit

    2013-01-01

    Full Text Available We present a team analysis of a slotted random wireless channel access mechanism. Under the proposed scheme, denoted wireless random access mechanism with multiple power levels (MPL-WRA, each mobile station contends for a transmission opportunity following the principles of a slotted access mechanism incorporating a random transmitting power value selected among various available power levels. In this way, a capture effect may be produced allowing the packet to be decoded whenever the signal-to-interference-plus-noise ratio is higher than a given threshold. In order to analyze the performance and optimization of the proposed setup, we build a Markovian model integrating the wireless access mechanism supplemented by the use of multiple power levels in an attractive and simple cross-layer fashion. We follow a team problem approach allowing us to fine tune the design parameters of the overall system configuration. Throughout an extensive numerical analysis, our main results set the basis for the social optimal system configuration of the proposed mechanism taking into account the physical constraints of using multiple power levels and the actual practical implementation of a slotted access mechanism. We end the paper with concluding remarks and future research directions including guidelines for the actual implementation of our proposal.

  1. Performance Analysis of Multi-Service Oriented Multiple Access Under General Channel Correlation

    OpenAIRE

    Ksairi, Nassar; Debbah, Mérouane

    2017-01-01

    In this article, we provide both analytical and numerical performance analysis of multi-service oriented multiple access (MOMA), a recently proposed non-orthogonal multiple-access scheme for scenarios with a massive number of concurrent connections originating from separate service classes with diverse quality-of-service (QoS) profiles and running on both handheld terminals and Internet-of-Things (IoT) devices. MOMA is based on both class dependent hierarchical-spreading transmission scheme a...

  2. Transistorized Marx bank pulse circuit provides voltage multiplication with nanosecond rise-time

    Science.gov (United States)

    Jung, E. A.; Lewis, R. N.

    1968-01-01

    Base-triggered avalanche transistor circuit used in a Marx bank pulser configuration provides voltage multiplication with nanosecond rise-time. The avalanche-mode transistors replace conventional spark gaps in the Marx bank. The delay time from an input signal to the output signal to the output is typically 6 nanoseconds.

  3. The Effect of Performance Feedback Provided to Student-Teachers Working with Multiple Disabilities

    Science.gov (United States)

    Safak, Pinar; Yilmaz, Hatice Cansu; Demiryurek, Pinar; Dogus, Mustafa

    2016-01-01

    The aim of the study was to investigate the effect of performance feedback (PF) provided to student teachers working with students with multiple disabilities and visual impairment (MDVI) on their teaching skills. The study group of the research was composed of 11 student teachers attending to the final year of the Teaching Students with Visual…

  4. Thermal and Hydraulic Performances of Nanofluids Flow in Microchannel Heat Sink with Multiple Zigzag Flow Channels

    Directory of Open Access Journals (Sweden)

    Duangthongsuk Weerapun

    2017-01-01

    Full Text Available This article presents an experimental investigation on the heat transfer performance and pressure drop characteristic of two types of nanofluids flowing through microchannel heat sink with multiple zigzag flow channel structures (MZMCHS. SiO2 nanoparticles dispersed in DI water with concentrations of 0.3 and 0.6 vol.% were used as working fluid. MZMCHS made from copper material with dimension of 28 × 33 mm. Hydraulic diameter of MZMCHs is designed at 1 mm, 7 number of flow channels and heat transfer area is about 1,238 mm2. Effects of particle concentration and flow rate on the thermal and hydraulic performances are determined and then compare with the common base fluid. The results indicated that the heat transfer coefficient of nanofluids was higher than that of the water and increased with increasing particle concentration as well as Reynolds number. For pressure drop, the particle concentrations have no significant effect on the pressure drop across the test section.

  5. Impact of Co-Channel Interference on the Outage Performance Under Multiple Type II Relay Environments

    KAUST Repository

    Choi, Seyeong

    2017-11-15

    In this paper, through an exact analysis of the outage probability, we investigate the impact of co-channel interference (CCI) on the outage performance of type II (or user equipment) relay under multiple-relay environments considering the selection combining-based relay selection scheme with the decode-and-forward protocol. We consider the signal to interference plus noise ratio (SINR) over both independent and identically distributed and independent but non-identically distributed fading channels. To fully take into account the effect of CCI, we adopt a more practical parameter such as the CCI coefficient. The major difficulty in the analysis resides in the determination of the statistics of the output SINR. To settle this problem, we first present the general but relatively simplified expressions for the statistics and then the related outage probability in closed-form. Furthermore, to consider more practical scenario, based on the fact that the number of participating relays can be random, we investigate the average outage probability by averaging the number of participating relays.

  6. Multiple mutations and mutation combinations in the sodium channel of permethrin resistant mosquitoes, Culex quinquefasciatus

    Science.gov (United States)

    Li, Ting; Zhang, Lee; Reid, William R.; Xu, Qiang; Dong, Ke; Liu, Nannan

    2012-10-01

    A previous study identified 3 nonsynonymous and 6 synonymous mutations in the entire mosquito sodium channel of Culex quinquefasciatus, the prevalence of which were strongly correlated with levels of resistance and increased dramatically following insecticide selection. However, it is unclear whether this is unique to this specific resistant population or is a common mechanism in field mosquito populations in response to insecticide pressure. The current study therefore further characterized these mutations and their combinations in other field and permethrin selected Culex mosquitoes, finding that the co-existence of all 9 mutations was indeed correlated with the high levels of permethrin resistance in mosquitoes. Comparison of mutation combinations revealed several common mutation combinations presented across different field and permethrin selected populations in response to high levels of insecticide resistance, demonstrating that the co-existence of multiple mutations is a common event in response to insecticide resistance across different Cx. quinquefasciatus mosquito populations.

  7. Characterization and Optimization of LDPC Codes for the 2-User Gaussian Multiple Access Channel

    Directory of Open Access Journals (Sweden)

    Declercq David

    2007-01-01

    Full Text Available We address the problem of designing good LDPC codes for the Gaussian multiple access channel (MAC. The framework we choose is to design multiuser LDPC codes with joint belief propagation decoding on the joint graph of the 2-user case. Our main result compared to existing work is to express analytically EXIT functions of the multiuser decoder with two different approximations of the density evolution. This allows us to propose a very simple linear programming optimization for the complicated problem of LDPC code design with joint multiuser decoding. The stability condition for our case is derived and used in the optimization constraints. The codes that we obtain for the 2-user case are quite good for various rates, especially if we consider the very simple optimization procedure.

  8. Optimal design of queueing systems for using communication channels with multiple access

    Science.gov (United States)

    Sonkin, D. M.; Nazarov, A. A.; Khrul, S. A.; Kudryashova, A. V.

    2017-01-01

    This article considers the mathematical model of queueing systems for the communication network with multiple access, which is used in the automated group of moving objects control systems. The dynamic communication model in the form of a single-line queuing model with the batch input claims was researched. The method of asymptotic analysis of the communication channel under a heavy load conditions was applied. As a result, the basic probabilistic characteristics of the system were obtained, including: the probability distribution of the waiting time values of the virtual claims, the average length of the queue claims at random time. It has been discovered that the characteristics of the communications models allow performing parametric optimization of communication networks, establishing the most appropriate values of the network parameters.

  9. Analyzing the trade-off between multiple memory controllers and memory channels on multi-core processor performance

    Energy Technology Data Exchange (ETDEWEB)

    Sancho Pitarch, Jose Carlos [Los Alamos National Laboratory; Kerbyson, Darren [Los Alamos National Laboratory; Lang, Mike [Los Alamos National Laboratory

    2010-01-01

    Increasing the core-count on current and future processors is posing critical challenges to the memory subsystem to efficiently handle concurrent memory requests. The current trend to cope with this challenge is to increase the number of memory channels available to the processor's memory controller. In this paper we investigate the effectiveness of this approach on the performance of parallel scientific applications. Specifically, we explore the trade-off between employing multiple memory channels per memory controller and the use of multiple memory controllers. Experiments conducted on two current state-of-the-art multicore processors, a 6-core AMD Istanbul and a 4-core Intel Nehalem-EP, for a wide range of production applications shows that there is a diminishing return when increasing the number of memory channels per memory controller. In addition, we show that this performance degradation can be efficiently addressed by increasing the ratio of memory controllers to channels while keeping the number of memory channels constant. Significant performance improvements can be achieved in this scheme, up to 28%, in the case of using two memory controllers with each with one channel compared with one controller with two memory channels.

  10. RD Optimized, Adaptive, Error-Resilient Transmission of MJPEG2000-Coded Video over Multiple Time-Varying Channels

    Directory of Open Access Journals (Sweden)

    Bezan Scott

    2006-01-01

    Full Text Available To reliably transmit video over error-prone channels, the data should be both source and channel coded. When multiple channels are available for transmission, the problem extends to that of partitioning the data across these channels. The condition of transmission channels, however, varies with time. Therefore, the error protection added to the data at one instant of time may not be optimal at the next. In this paper, we propose a method for adaptively adding error correction code in a rate-distortion (RD optimized manner using rate-compatible punctured convolutional codes to an MJPEG2000 constant rate-coded frame of video. We perform an analysis on the rate-distortion tradeoff of each of the coding units (tiles and packets in each frame and adapt the error correction code assigned to the unit taking into account the bandwidth and error characteristics of the channels. This method is applied to both single and multiple time-varying channel environments. We compare our method with a basic protection method in which data is either not transmitted, transmitted with no protection, or transmitted with a fixed amount of protection. Simulation results show promising performance for our proposed method.

  11. Methods for providing decision makers with optimal solutions for multiple objectives that change over time

    CSIR Research Space (South Africa)

    Greeff, M

    2010-09-01

    Full Text Available for providing decision makers with optimal solutions for multiple objectives that change over time M GREEFF CSIR Meraka Institute, PO Box 395, Pretoria, 0001, South Africa Email: mgreeff@csir.co.za – www.csir.co.za IntroductIon decision making... solution, but a set of optimal solutions, called the Pareto optimal front (PoF). When the objectives change over time, the problem is called a dynamic mooP (dmooP). this research focuses on finding the PoF for dmooPs, in order to provide the decision...

  12. Kinetic model of Nav1.5 channel provides a subtle insight into slow inactivation associated excitability in cardiac cells.

    Directory of Open Access Journals (Sweden)

    Zheng Zhang

    Full Text Available Voltage-gated sodium channel Nav1.5 has been linked to the cardiac cell excitability and a variety of arrhythmic syndromes including long QT, Brugada, and conduction abnormalities. Nav1.5 exhibits a slow inactivation, corresponding to a duration-dependent bi-exponential recovery, which is often associated with various arrhythmia syndromes. However, the gating mechanism of Nav1.5 and the physiological role of slow inactivation in cardiac cells remain elusive. Here a 12-state two-step inactivation Markov model was successfully developed to depict the gating kinetics of Nav1.5. This model can simulate the Nav1.5 channel in not only steady state processes, but also various transient processes. Compared with the simpler 8-state model, this 12-state model is well-behaved in simulating and explaining the processes of slow inactivation and slow recovery. This model provides a good framework for further studying the gating mechanism and physiological role of sodium channel in excitable cells.

  13. To provide care and be cared for in a multiple-bed hospital room.

    Science.gov (United States)

    Persson, Eva; Määttä, Sylvia

    2012-12-01

    To illuminate patients' experiences of being cared for and nurses' experiences of caring for patients in a multiple-bed hospital room. Many patients and healthcare personnel seem to prefer single-bed hospital rooms. However, certain advantages of multiple-bed hospital rooms (MBRs) have also been described. Eight men and eight women being cared for in a multiple-bedroom were interviewed, and two focus-group interviews (FGI) with 12 nurses were performed. A qualitative content analysis was used. One theme--Creating a sphere of privacy--and three categories were identified based on the patient interviews. The categories were: Being considerate, Having company and The patients' area. In the FGI, one theme--Integrating individual care with care for all--and two categories emerged: Experiencing a friendly atmosphere and Providing exigent care. Both patients and nurses described the advantages and disadvantages of multiple-bed rooms. The patient culture of taking care of one another and enjoying the company of room-mates were considered positive and gave a sense of security of both patients and nurses. The advantages were slight and could easily become disadvantages if, for example, room-mates were very ill or confused. The patients tried to maintain their privacy and dignity and claimed that there were small problems with room-mates listening to conversations. In contrast, the nurses stressed patient integrity as a main disadvantage and worked to protect the integrity of individual patients. Providing care for all patients simultaneously had the advantage of saving time. The insights gained in the present study could assist nurses in reducing the disadvantages and taking advantage of the positive elements of providing care in MBRs. Health professionals need to be aware of how attitudes towards male and female patients, respectively, could affect care provision. © 2012 The Authors. Scandinavian Journal of Caring Sciences © 2012 Nordic College of Caring Science.

  14. Channel capacity of TDD-OFDM-MIMO for multiple access points in a wireless single-frequency-network

    DEFF Research Database (Denmark)

    Takatori, Y.; Fitzek, Frank; Tsunekawa, K.

    2005-01-01

    MIMO data transmission scheme, which combines Single-Frequency-Network (SFN) with TDD-OFDM-MIMO applied for wireless LAN networks. In our proposal, we advocate to use SFN for multiple access points (MAP) MIMO data transmission. The goal of this approach is to achieve very high channel capacity in both...

  15. Patient and provider perspectives on the relationship between multiple morbidity management and disease prevention.

    Science.gov (United States)

    Schoenberg, Nancy E; Tarasenko, Yelena N; Bardach, Shoshana H; Fleming, Steven T

    2015-04-01

    Despite competing demands of multiple morbidity (MM) management and disease prevention, our recent survey of 1,153 Appalachian residents aged 50 to 76 documented that individuals with MM were more likely to obtain colorectal cancer screening (CRCS) than those without MM. Nearly two thirds of respondents obtained CRCS, and the more MM, the greater the likelihood of screening. To gain insight into this relationship, we conducted nine focus groups, six with providers and three with patients. Three main explanations emerged: (a) patients' MM increases providers' vigilance for other health vulnerabilities; (b) having MM increases patients' own vigilance; and (c) patients' vigilance may stem from experiencing more symptoms, having a family history of cancer, and having successfully obtained health care. More frequent contact with health care providers appears to encourage preventive referral, especially in low-income populations that otherwise may not receive such counselling. We highlight participant recommendations to improve MM management and prevention. © The Author(s) 2013.

  16. Online response-selection and the attentional blink: Multiple-processing channels.

    Science.gov (United States)

    Serences, John; Scolari, Miranda; Awh, Edward

    2009-01-01

    Robust interference often arises when multiple targets (T1 and T2) are discriminated in rapid succession (the attentional blink or AB). The AB has been observed for a wide range of stimuli, and is often thought to reflect a central capacity limitation in working memory consolidation, attentional engagement, and/or online response selection. However, recent evidence challenges the existence of unitary bottleneck during postperceptual processing. Awh et al. (2004) found no AB interference when a digit target preceded a face target, presumably because these stimuli could be processed by means of separable processing channels. Using a modified AB procedure, recent studies have also demonstrated that speeded response selection of T1 leads to an AB effect for T2 identification, supporting the conclusion that response selection induces the same processing limitations that typically gives rise to an AB. The present research tests this hypothesis by examining the effects of response selection on the identification of faces. Although we replicated previous demonstrations that online response selection of a digit disrupts the identification of T2 letters, we found no interference in the identification of T2 faces. However, robust AB interference was once again observed when a speeded response to a T1 face was required, confirming that faces are not simply immune to central interference. These results dispute the existence of a unitary postperceptual capacity limitation that gives rise to the AB.

  17. Quantitative measures of walking and strength provide insight into brain corticospinal tract pathology in multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Nora E Fritz

    2017-01-01

    Quantitative measures of strength and walking are associated with brain corticospinal tract pathology. The addition of these quantitative measures to basic clinical information explains more of the variance in corticospinal tract fractional anisotropy and magnetization transfer ratio than the basic clinical information alone. Outcome measurement for multiple sclerosis clinical trials has been notoriously challenging; the use of quantitative measures of strength and walking along with tract-specific imaging methods may improve our ability to monitor disease change over time, with intervention, and provide needed guidelines for developing more effective targeted rehabilitation strategies.

  18. Technology-Enhanced Peer Review: Benefits and Implications of Providing Multiple Reviews

    DEFF Research Database (Denmark)

    Papadopoulos, Pantelis M.; Lagkas, Thomas D.; Demetriadis, Stavros N.

    2016-01-01

    This study analyses the impact of self and peer feedback in technology-enhanced peer review settings. The impact of receiving peer comments (“receiver” perspective) is compared to that of reaching own insights by reviewing others’ work (“giver” perspective). In this study, 38 sophomore students...... were randomly assigned in two conditions and engaged in peer review activity facilitated by a web-based learning environment asking them to provide multiple reviews. In the Peer Reviewed (PR) condition students both reviewed peer work and received peer comments for their own work. By contrast......, in the Self Reviewed (SR) condition students provided peer reviews, but did not receive any. Instead, they were asked to perform self reviewing, before proceeding to any revisions of their work. Result showed that the two groups were comparable in all aspects, suggesting that the lack of getting peer reviews...

  19. Technology-Enhanced Peer Review: Benefits and Implications of Providing Multiple Reviews

    DEFF Research Database (Denmark)

    Papadopoulos, Pantelis M.; Lagkas, Thomas D.; Demetriadis, Stavros N.

    2017-01-01

    This study analyses the impact of self and peer feedback in technology-enhanced peer review settings. The impact of receiving peer comments (“receiver” perspective) is compared to that of reaching own insights by reviewing others’ work (“giver” perspective). In this study, 38 sophomore students...... were randomly assigned in two conditions and engaged in peer review activity facilitated by a web-based learning environment asking them to provide multiple reviews. In the Peer Reviewed (PR) condition students both reviewed peer work and received peer comments for their own work. By contrast......, in the Self Reviewed (SR) condition students provided peer reviews, but did not receive any. Instead, they were asked to perform self reviewing, before proceeding to any revisions of their work. Result showed that the two groups were comparable in all aspects, suggesting that the lack of getting peer reviews...

  20. Multiple sclerosis patients need and want information on exercise promotion from healthcare providers: a qualitative study.

    Science.gov (United States)

    Learmonth, Yvonne C; Adamson, Brynn C; Balto, Julia M; Chiu, Chung-Yi; Molina-Guzman, Isabel; Finlayson, Marcia; Riskin, Barry J; Motl, Robert W

    2017-08-01

    There is growing recognition of the benefits and safety of exercise and its importance in the comprehensive care of persons with multiple sclerosis (MS), yet uptake is low. We explored the needs and wants of patients with MS regarding exercise promotion through healthcare providers. Participants were adults with MS who had mild-or-moderate disability and a range of exercise levels. All participants lived in the Midwest of the United States. Fifty semi-structured interviews were conducted and analysed using thematic analysis. Two themes emerged, namely interactions between patients and healthcare providers and needs and wants of patients. Analysis of participant accounts illustrate that current exercise promotion by healthcare providers does not meet patient needs and wants. The identified needs and wants of persons with MS involved (i) information and knowledge on the benefits of exercise and exercise prescription, (ii) materials to allow home and community exercise and (iii) tools for initiating and maintaining exercise behaviour. Patients with MS frequently interact with healthcare providers and are generally unsatisfied with exercise promotion during interactions. Healthcare providers can address the low uptake of exercise among persons with MS by acting upon the identified unmet needs involving materials, knowledge and behaviour change strategies for exercise. © 2016 The Authors Health Expectations Published by John Wiley & Sons Ltd.

  1. Rheology of the Cu-H2O nanofluid in porous channel with heat transfer: Multiple solutions

    Science.gov (United States)

    Raza, J.; Rohni, A. M.; Omar, Z.; Awais, M.

    2017-02-01

    Dynamics of nanofluid comprising a base fluid (water) with copper (Cu) nanoparticles have been considered in channel with porous walls under magnetic field influence. The channel walls are considered to be permeable in order to analyze the wall mass transfer phenomenon. Relevant mathematical modelling has been performed and the derived PDEs are converted into coupled nonlinear ODEs by using suitable transformations. Computations have been made numerically by employing the shooting technique. It is noted that multiple solutions occur for the variation of suction Reynolds number, solid volume fraction and magnetic parameters which are interpreted in detail.

  2. The Acinetobacter Outer Membrane Contains Multiple Specific Channels for Carbapenem β-Lactams as Revealed by Kinetic Characterization Analyses of Imipenem Permeation into Acinetobacter baylyi Cells.

    Science.gov (United States)

    Morán-Barrio, Jorgelina; Cameranesi, María M; Relling, Verónica; Limansky, Adriana S; Brambilla, Luciano; Viale, Alejandro M

    2017-03-01

    The number and type of outer membrane (OM) channels responsible for carbapenem uptake in Acinetobacter are still not well defined. Here, we addressed these questions by using Acinetobacter baylyi as a model species and a combination of methodologies aimed to characterize OM channels in their original membrane environment. Kinetic and competition analyses of imipenem (IPM) uptake by A. baylyi whole cells allowed us to identify different carbapenem-specific OM uptake sites. Comparative analyses of IPM uptake by A. baylyi wild-type (WT) cells and ΔcarO mutants lacking CarO indicated that this OM protein provided a carbapenem uptake site displaying saturable kinetics and common binding sites for basic amino acids compatible with a specific channel. The kinetic analysis uncovered another carbapenem-specific channel displaying a somewhat lower affinity for IPM than that of CarO and, in addition, common binding sites for basic amino acids as determined by competition studies. The use of A. baylyi gene deletion mutants lacking OM proteins proposed to function in carbapenem uptake in Acinetobacter baumannii indicated that CarO and OprD/OccAB1 mutants displayed low but consistent reductions in susceptibility to different carbapenems, including IPM, meropenem, and ertapenem. These two mutants also showed impaired growth on l-Arg but not on other carbon sources, further supporting a role of CarO and OprD/OccAB1 in basic amino acid and carbapenem uptake. A multiple-carbapenem-channel scenario may provide clues to our understanding of the contribution of OM channel loss or mutation to the carbapenem-resistant phenotype evolved by pathogenic members of the Acinetobacter genus. Copyright © 2017 American Society for Microbiology.

  3. Time-weighted attribution of revenue to multiple e-commerce marketing channels in the customer journey.

    OpenAIRE

    Wooff, D.A.; Anderson, J M

    2013-01-01

    In this paper we address statistical issues in attributing revenue to marketing channels. We describe the relevant data structures and introduce an example. We suggest an asymmetric bathtub shape as appropriate for time-weighted revenue attribution to the customer journey, provide an algorithm, and illustrate the method. We suggest a modification to this method when there is independent information available on the relative values of the channels. We compare the revenue attributio...

  4. Multiple mechanisms underlying rectification in retinal cyclic nucleotide-gated (CNGA1) channels.

    Science.gov (United States)

    Arcangeletti, Manuel; Marchesi, Arin; Mazzolini, Monica; Torre, Vincent

    2013-11-01

    In cyclic nucleotide-gated (CNGA1) channels, in the presence of symmetrical ionic conditions, current-voltage (I-V) relationship depends, in a complex way, on the radius of permeating ion. It has been suggested that both the pore and S4 helix contribute to the observed rectification. In the present manuscript, using tail and gating current measurements from homotetrameric CNGA1 channels expressed in Xenopus oocytes, we clarify and quantify the role of the pore and of the S4 helix. We show that in symmetrical Rb(+) and Cs(+) single-channel current rectification dominates macroscopic currents while voltage-dependent gating becomes larger in symmetrical ethylammonium and dimethylammonium, where the open probability strongly depends on voltage. Isochronal tail currents analysis in dimethylammonium shows that at least two voltage-dependent transitions underlie the observed rectification. Only the first voltage-dependent transition is sensible to mutation of charge residues in the S4 helix. Moreover, analysis of tail and gating currents indicates that the number of elementary charges per channel moving across the membrane is less than 2, when they are about 12 in K(+) channels. These results indicate the existence of distinct mechanisms underlying rectification in CNG channels. A restricted motion of the S4 helix together with an inefficient coupling to the channel gate render CNGA1 channels poorly sensitive to voltage in the presence of physiological Na(+) and K(+).

  5. Multiple mechanisms underlying rectification in retinal cyclic nucleotide-gated (CNGA1) channels

    Science.gov (United States)

    Arcangeletti, Manuel; Marchesi, Arin; Mazzolini, Monica; Torre, Vincent

    2013-01-01

    In cyclic nucleotide-gated (CNGA1) channels, in the presence of symmetrical ionic conditions, current–voltage (I-V) relationship depends, in a complex way, on the radius of permeating ion. It has been suggested that both the pore and S4 helix contribute to the observed rectification. In the present manuscript, using tail and gating current measurements from homotetrameric CNGA1 channels expressed in Xenopus oocytes, we clarify and quantify the role of the pore and of the S4 helix. We show that in symmetrical Rb+ and Cs+ single-channel current rectification dominates macroscopic currents while voltage-dependent gating becomes larger in symmetrical ethylammonium and dimethylammonium, where the open probability strongly depends on voltage. Isochronal tail currents analysis in dimethylammonium shows that at least two voltage-dependent transitions underlie the observed rectification. Only the first voltage-dependent transition is sensible to mutation of charge residues in the S4 helix. Moreover, analysis of tail and gating currents indicates that the number of elementary charges per channel moving across the membrane is less than 2, when they are about 12 in K+ channels. These results indicate the existence of distinct mechanisms underlying rectification in CNG channels. A restricted motion of the S4 helix together with an inefficient coupling to the channel gate render CNGA1 channels poorly sensitive to voltage in the presence of physiological Na+ and K+. PMID:24400150

  6. The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.

    NARCIS (Netherlands)

    Kovalevskaya, N.V.; Bokhovchuk, F.M.; Vuister, G.W.

    2012-01-01

    The epithelial Ca(2+) channels TRPV5/6 (transient receptor potential vanilloid 5/6) are thoroughly regulated in order to fine-tune the amount of Ca(2+) reabsorption. Calmodulin has been shown to be involved into calcium-dependent inactivation of TRPV5/6 channels by binding directly to the distal

  7. Calcium channels blocked activity: Providing the basis for medicinal use of Abies pindrow in diarrhea and bronchitis

    Directory of Open Access Journals (Sweden)

    Sohaib Mushtaq

    2015-06-01

    Full Text Available Abies pindrow is widely used in traditional practice for the treatment of diarrhea and bronchitis and the present study was designed to validate its folkloric uses. The crude extract of A. pindrow inhibit spontaneously contracting (1-10 mg/mL and high K+ (80 mM-induced pre-contracted rabbit jejun-um (3 mg/mL in concentration dependent manner. A rightward shift in Ca+2 concentration response curves was seen in the presence of crude extract (0.1-0.3, similar to verapamil. In isolated tracheal tissue, A. pindrow inhibited, high K+ and carbachol (1 µM-induced contractions, at 3 mg/mL and 10 mg/mL respectively, similar to that caused by verapamil. These results indicate the presence of calcium channels blocked activity in crude extract of A. pindrow, which provide sound basis for medicinal uses of A. pindrow in diarrhea and bronchitis.

  8. Customer Engagement Tool (Multi Channel Communication)

    Data.gov (United States)

    Social Security Administration — Add new infrastructure within SSA's Enterprise Architecture to allow interactions over multiple, yet to be defined, channels. Possibilities include: Provide a portal...

  9. A study of natural convection cooling of multiple discrete heat sources in a vertical channel

    Science.gov (United States)

    Willson, Thomas D.

    1988-06-01

    Natural convection liquid cooling of simulated electronic components in a vertical channel was investigated. The test surface contained a single column of eight rectangular, protruding heated elements, each simulating a 20 pin dual-in-line package. Temperature measurements and flow visualization were performed for a number of power dissipation levels and channel widths. Collectively, this information was used in interpreting the flow and transport characteristics. A correlation to predict the heat transfer rates was developed based on the component surface temperatures. Optimum channel widths were determined from these surface temperature measurements for the range of power levels investigated. Temperature distributions in the fluid were measured using a traversing thermocouple probe.

  10. How to combine multiple techniques to provide reliable in-situ time series for climate applications

    Science.gov (United States)

    Valladeau, G.; Soudarin, L.; Gravelle, M.

    2012-12-01

    Tide gauge measurements, as observations dedicated to climate applications, require a rigorous quality control since measurements are highly sensitive to biases or drifts in datasets. One major part of the error related to the assessment of Sea Surface Height at tide gauge location originates in vertical movements. Indeed, many studies have for instance demonstrated the need for tide gauges to be corrected for land motion when compared with altimeter data. The combination of multiple techniques (altimeter, in-situ and geodetic data) is a way of providing relevant tide gauge time series for end-users and climate applications such as the contribution of ice-sheet mass balance to the global sea-level. In this way, DORIS (Doppler Orbitography and Radiopositioning Integrated by Satellite) as well as GNSS (Global Navigation Satellite System) are considered as complementary techniques. They determine the crustal motion at a cm (or better) and mm/yr accuracy for the positions and velocities respectively. As the DORIS network was deployed by a geodetic institution, great care was taken when selecting the geographical location of the tracking stations to co-locate them with other space geodetic techniques (VLBI, SLR and GNSS), but also with tide gauges. Hence, as on May 2012, 22 DORIS stations are within 10 km from a tide gauge, including 8 within 500m. Ties between the DORIS antennas and the nearby tide gauge are also available when the measurement is possible. This study focuses on the example of the Thule tide gauge for which measurements are compared to the different techniques previously described. First, the comparison to both DORIS and GNSS data provides relevant information about the strong crustal movement North of Greenland. Then the use of altimeter data confirms results deduced from geodetic stations and give a larger view on the behavior of land motion around the Thule tide gauge. Therefore, the combination of multiple techniques is used to provide reliable tide

  11. Multiple genetic interaction experiments provide complementary information useful for gene function prediction.

    Directory of Open Access Journals (Sweden)

    Magali Michaut

    Full Text Available Genetic interactions help map biological processes and their functional relationships. A genetic interaction is defined as a deviation from the expected phenotype when combining multiple genetic mutations. In Saccharomyces cerevisiae, most genetic interactions are measured under a single phenotype - growth rate in standard laboratory conditions. Recently genetic interactions have been collected under different phenotypic readouts and experimental conditions. How different are these networks and what can we learn from their differences? We conducted a systematic analysis of quantitative genetic interaction networks in yeast performed under different experimental conditions. We find that networks obtained using different phenotypic readouts, in different conditions and from different laboratories overlap less than expected and provide significant unique information. To exploit this information, we develop a novel method to combine individual genetic interaction data sets and show that the resulting network improves gene function prediction performance, demonstrating that individual networks provide complementary information. Our results support the notion that using diverse phenotypic readouts and experimental conditions will substantially increase the amount of gene function information produced by genetic interaction screens.

  12. Multiple kisspeptin receptors in early osteichthyans provide new insights into the evolution of this receptor family.

    Directory of Open Access Journals (Sweden)

    Jérémy Pasquier

    Full Text Available Deorphanization of GPR54 receptor a decade ago led to the characterization of the kisspeptin receptor (Kissr in mammals and the discovery of its major role in the brain control of reproduction. While a single gene encodes for Kissr in eutherian mammals including human, other vertebrates present a variable number of Kissr genes, from none in birds, one or two in teleosts, to three in an amphibian, xenopus. In order to get more insight into the evolution of Kissr gene family, we investigated the presence of Kissr in osteichthyans of key-phylogenetical positions: the coelacanth, a representative of early sarcopterygians, the spotted gar, a non-teleost actinopterygian, and the European eel, a member of an early group of teleosts (elopomorphs. We report the occurrence of three Kissr for the first time in a teleost, the eel. As measured by quantitative RT-PCR, the three eel Kissr were differentially expressed in the brain-pituitary-gonadal axis, and differentially regulated in experimentally matured eels, as compared to prepubertal controls. Subfunctionalisation, as shown by these differences in tissue distribution and regulation, may have represented significant evolutionary constraints for the conservation of multiple Kissr paralogs in this species. Furthermore, we identified four Kissr in both coelacanth and spotted gar genomes, providing the first evidence for the presence of four Kissr in vertebrates. Phylogenetic and syntenic analyses supported the existence of four Kissr paralogs in osteichthyans and allowed to propose a clarified nomenclature of Kissr (Kissr-1 to -4 based on these paralogs. Syntenic analysis suggested that the four Kissr paralogs arose through the two rounds of whole genome duplication (1R and 2R in early vertebrates, followed by multiple gene loss events in the actinopterygian and sarcopterygian lineages. Due to gene loss there was no impact of the teleost-specific whole genome duplication (3R on the number of Kissr paralogs

  13. The Diversity-Multiplexing Tradeoff of Secret-Key Agreement over Multiple-Antenna Channels

    KAUST Repository

    Zorgui, Marwen

    2015-10-26

    We study the problem of secret-key agreement between two legitimate parties, Alice and Bob, in presence an of eavesdropper Eve. There is a public channel with unlimited capacity that is available to the legitimate parties and is also observed by Eve. Our focus is on Rayleigh fading quasi-static channels. The legitimate receiver and the eavesdropper are assumed to have perfect channel knowledge of their channels. We study the system in the high-power regime. First, we define the secret-key diversity gain and the secret-key multiplexing gain. Second, we establish the secret-key diversity multiplexing tradeoff (DMT) under no channel state information (CSI) at the transmitter (CSI-T). The eavesdropper is shown to “steal” only transmit antennas. We show that, likewise the DMT without secrecy constraint, the secret-key DMT is the same either with or without full channel state information at the transmitter. This insensitivity of secret-key DMT toward CSI-T features a fundamental difference between secret-key agreement and the wiretap channel, in which secret DMT depends heavily on CSI-T. Finally, we present several secret-key DMT-achieving schemes in case of full CSI-T. We argue that secret DMT-achieving schemes are also key DMT-achieving. Moreover, we show formally that artificial noise (AN), likewise zero-forcing (ZF), is DMT-achieving. We also show that the public feedback channel improves the outage performance without having any effect on the DMT.

  14. Critical side channel effects in random bit generation with multiple semiconductor lasers in a polarization-based quantum key distribution system.

    Science.gov (United States)

    Ko, Heasin; Choi, Byung-Seok; Choe, Joong-Seon; Kim, Kap-Joong; Kim, Jong-Hoi; Youn, Chun Ju

    2017-08-21

    Most polarization-based BB84 quantum key distribution (QKD) systems utilize multiple lasers to generate one of four polarization quantum states randomly. However, random bit generation with multiple lasers can potentially open critical side channels that significantly endangers the security of QKD systems. In this paper, we show unnoticed side channels of temporal disparity and intensity fluctuation, which possibly exist in the operation of multiple semiconductor laser diodes. Experimental results show that the side channels can enormously degrade security performance of QKD systems. An important system issue for the improvement of quantum bit error rate (QBER) related with laser driving condition is further addressed with experimental results.

  15. On the diversity-multiplexing tradeoff of secret-key agreement over multiple-antenna channels

    KAUST Repository

    Zorgui, Marwen

    2014-09-01

    We consider secret-key agreement with public discussion over Rayleigh fading quasi-static channels. First, the secret-key diversity gain and the secret-key multiplexing gain are defined. Then, the secret-key diversity multiplexing tradeoff (DMT) is established. The eavesdropper is shown to \\'steal\\' only transmit antennas. We show that likewise the DMT without secrecy constraint, the secret-key DMT is the same either with or without full channel state information (CSI) at the transmitter (CSI-T). This insensitivity of secret-key DMT toward CSI-T highlights a fundamental difference between secret-key agreement and the wiretap channel whose secret DMT depends crucially on CSI-T. Several secret-key DMT-achieving schemes are presented in case of full CSI-T.

  16. Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Mahy Nicole

    2011-11-01

    Full Text Available Abstract Background Multiple Sclerosis (MS is an acquired inflammatory demyelinating disorder of the central nervous system (CNS and is the leading cause of nontraumatic disability among young adults. Activated microglial cells are important effectors of demyelination and neurodegeneration, by secreting cytokines and others neurotoxic agents. Previous studies have demonstrated that microglia expresses ATP-sensitive potassium (KATP channels and its pharmacological activation can provide neuroprotective and anti-inflammatory effects. In this study, we have examined the effect of oral administration of KATP channel opener diazoxide on induced experimental autoimmune encephalomyelitis (EAE, a mouse model of MS. Methods Anti-inflammatory effects of diazoxide were studied on lipopolysaccharide (LPS and interferon gamma (IFNγ-activated microglial cells. EAE was induced in C57BL/6J mice by immunization with myelin oligodendrocyte glycoprotein peptide (MOG35-55. Mice were orally treated daily with diazoxide or vehicle for 15 days from the day of EAE symptom onset. Treatment starting at the same time as immunization was also assayed. Clinical signs of EAE were monitored and histological studies were performed to analyze tissue damage, demyelination, glial reactivity, axonal loss, neuronal preservation and lymphocyte infiltration. Results Diazoxide inhibited in vitro nitric oxide (NO, tumor necrosis factor alpha (TNF-α and interleukin-6 (IL-6 production and inducible nitric oxide synthase (iNOS expression by activated microglia without affecting cyclooxygenase-2 (COX-2 expression and phagocytosis. Oral treatment of mice with diazoxide ameliorated EAE clinical signs but did not prevent disease. Histological analysis demonstrated that diazoxide elicited a significant reduction in myelin and axonal loss accompanied by a decrease in glial activation and neuronal damage. Diazoxide did not affect the number of infiltrating lymphocytes positive for CD3 and CD20

  17. Allitridi inhibits multiple cardiac potassium channels expressed in HEK 293 cells.

    Directory of Open Access Journals (Sweden)

    Xiao-Hui Xu

    Full Text Available Allitridi (diallyl trisulfide is an active compound (volatile oil from garlic. The previous studies reported that allitridi had anti-arrhythmic effect. The potential ionic mechanisms are, however, not understood. The present study was designed to determine the effects of allitridi on cardiac potassium channels expressed in HEK 293 cells using a whole-cell patch voltage-clamp technique and mutagenesis. It was found that allitridi inhibited hKv4.3 channels (IC(50 = 11.4 µM by binding to the open channel, shifting availability potential to hyperpolarization, and accelerating closed-state inactivation of the channel. The hKv4.3 mutants T366A, T367A, V392A, and I395A showed a reduced response to allitridi with IC(50s of 35.5 µM, 44.7 µM, 23.7 µM, and 42.4 µM. In addition, allitridi decreased hKv1.5, hERG, hKCNQ1/hKCNE1 channels stably expressed in HEK 293 cells with IC(50s of 40.2 µM, 19.6 µM and 17.7 µM. However, it slightly inhibited hKir2.1 current (100 µM, inhibited by 9.8% at -120 mV. Our results demonstrate for the first time that allitridi preferably blocks hKv4.3 current by binding to the open channel at T366 and T367 of P-loop helix, and at V392 and I395 of S6 domain. It has a weak inhibition of hKv1.5, hERG, and hKCNQ1/hKCNE1 currents. These effects may account for its anti-arrhythmic effect observed in experimental animal models.

  18. Multiple-state based power control for multi-radio multi-channel wireless mesh networks

    CSIR Research Space (South Africa)

    Olwal, TO

    2009-01-01

    Full Text Available layers [1]. This results in independent communications in these radios. Thus, a single MP node can access mesh client network T. O. Olwal is with the Tshwane University of Technology, Paris-12 University and Meraka Institute at the CSIR, South...-channel medium access control was proposed in [10]. The developed dynamic channel assignment using the power control (DCA-PC) method has the advantage of being independent of dynamic topology and node degree [22]. Though, the DCA-PC is an energy...

  19. Double-Layer Low-Density Parity-Check Codes over Multiple-Input Multiple-Output Channels

    Directory of Open Access Journals (Sweden)

    Yun Mao

    2012-01-01

    Full Text Available We introduce a double-layer code based on the combination of a low-density parity-check (LDPC code with the multiple-input multiple-output (MIMO system, where the decoding can be done in both inner-iteration and outer-iteration manners. The present code, called low-density MIMO code (LDMC, has a double-layer structure, that is, one layer defines subcodes that are embedded in each transmission vector and another glues these subcodes together. It supports inner iterations inside the LDPC decoder and outeriterations between detectors and decoders, simultaneously. It can also achieve the desired design rates due to the full rank of the deployed parity-check matrix. Simulations show that the LDMC performs favorably over the MIMO systems.

  20. Assessing the relative importance of multiple channels for embodied and disembodied technological spillovers

    NARCIS (Netherlands)

    Krammer, Sorin M. S.

    With ever increasing global integration, productivity improvements depend not only on in-house innovative efforts, but on those of international partners as well. This paper explores the impact of foreign R&D on productivity and technical efficiency of countries by considering three channels of

  1. Performance analysis for a chaos-based code-division multiple access system in wide-band channel

    Directory of Open Access Journals (Sweden)

    Ciprian Doru Giurcăneanu

    2015-08-01

    Full Text Available Code-division multiple access technology is widely used in telecommunications and its performance has been extensively investigated in the past. Theoretical results for the case of wide-band transmission channel were not available until recently. The novel formulae which have been published in 2014 can have an important impact on the future of wireless multiuser communications, but limitations come from the Gaussian approximations used in their derivation. In this Letter, the authors obtain more accurate expressions of the bit error rate (BER for the case when the model of the wide-band channel is two-ray, with Rayleigh fading. In the authors’ approach, the spreading sequences are assumed to be generated by logistic map given by Chebyshev polynomial function of order two. Their theoretical and experimental results show clearly that the previous results on BER, which rely on the crude Gaussian approximation, are over-pessimistic.

  2. Turbo code channel reliability for DS/CDMA systems under slow and frequency selective fading and multiple access interference

    Directory of Open Access Journals (Sweden)

    Taufik Abrão

    2008-08-01

    Full Text Available This work analyzes the Turbo and Convolutional codes strategies applied to the single-user detection (SuD problem in multiple access systems DS/CDMA, in multipath slow Rayleigh channels. In this work, a new equation for the DS/CDMA channel reliability, obtained from Monte Carlo Simulations (MCS, is proposed. Comparison with the literature results and has indicated a superior performance in the high Eb/N0 regions; in other Eb/N0 regions the proposed equation has similar performance than those described in the literature. Additionally, this work makes an analysis of the complexity/memory requirements versus performance of DS/CDMA receivers considering turbo (CDMA2000 and Viterbi (IS-95 decoders.

  3. Cloning and characterization of multiple forms of the human kidney ROM-K potassium channel.

    Science.gov (United States)

    Shuck, M E; Bock, J H; Benjamin, C W; Tsai, T D; Lee, K S; Slightom, J L; Bienkowski, M J

    1994-09-30

    The rat kidney ROM-K1 potassium channel cDNA was used to clone the homolog from human kidney using a combination of cDNA cloning, reverse transcriptase-polymerase chain reaction (RT-PCR), and primer extension cloning methods. In addition to the human species homolog of ROM-K1, four additional transcripts that are formed by alternative splicing of a single human gene were also characterized (hROM-K2 to hROM-K5). All five transcripts share a common 3' exon that encodes the majority of the channel protein and in three of the isoforms translation is initiated at a start codon contained within this exon (hROM-K2, hROM-K4, and hROM-K5). The two other transcripts contain additional exons that potentially extend the open reading frame by either 19 amino acid residues (hROM-K1) or by 17 amino acid residues (hROM-K3). Comparison of the translation products from the three representative transcripts (hROM-K1, hROM-K2, and hROM-K3) confirmed that hROM-K1 gave the largest product (41.6 kDa) and was translated more efficiently than either hROM-K2 or hROM-K3. Also, despite the presence of several additional canonical acceptor sites for Asn-linked glycosylation relative to rat ROM-K1, all three channel polypeptides were glycosylated to a similar extent in the in vitro translation reactions when canine pancreatic microsomes were included. A survey of the tissue distribution of expression of the various forms in selected human tissues showed that the core-exon linked to all four possible 5' exons are detected almost exclusively in kidney. The core-exon was also detected in human kidney and lower amounts were detected in skeletal muscle > pancreas > spleen > brain = heart > liver RNAs by RT-PCR. Alternatively, Northern blot analysis of poly(A)+ RNAs from these same tissues revealed a 2.8-kilobase transcript only in kidney. Heterologous expression of either the hROM-K1, hROM-K2, or hROM-K3 channel transcripts in Xenopus oocytes led to the expression of K(+)-selective, Ba(2+)-sensitive

  4. Capacity bounds for the 2-user Gaussian IM-DD optical multiple-access channel

    KAUST Repository

    Al-Ebraheemy, Omer M. S.

    2016-11-01

    Optical wireless communications (OWC) is a potential solution for coping with the mismatch between the users growing demand for higher data-rates and the wireless network capabilities. In this paper, a multi-user OWC scenario is studied from an in formation-theoretic perspective. The studied network consists of two users communicating simultaneously with one access point using OWC, thus establishing an optical uplink channel. The capacity of this network is an important metric which reflects the highest possible communication rates that can be achieved over this channel. Capacity outer and inner bounds are derived, and are shown to be fairly tight in the high signal-to-noise ratio regime. © 2016 IEEE.

  5. Asymptotic BER analysis of FSO with multiple receive apertures over ℳ -distributed turbulence channels with pointing errors.

    Science.gov (United States)

    Yang, Liang; Hasna, Mazen Omar; Gao, Xiqi

    2014-07-28

    In this paper, we consider a free-space optical (FSO) communication with multiple receive apertures over ℳ -distributed turbulence channels with pointing errors. In particular, we consider two different combining schemes at the receiver: optimal combining (OC) and selection combining (SC). With these setups, the statistic characters of the instantaneous electrical signal-to-noise ratio (SNR) are derived. Then, using the cumulative density function (CDF)-based method, we analyze the asymptotic bit-error rate (BER) performance. The derived results help quantifying the diversity order of our considered systems.

  6. Involvement of multiple calcium channels in neurotransmitter release from cultured sympathetic neurons

    Energy Technology Data Exchange (ETDEWEB)

    Hirning, L.D.; Perney, T.M.; Miller, R.J.

    1986-03-01

    The release of neurotransmitters has been defined to be a Ca/sup + +/ dependent process, however, the role of Ca/sup + +/ channels in the release process is unclear. Primary cultures of sympathetic nerves from superior cervical ganglia were used to examine the specific actions of dihydropyridine (DHP) drugs. In nerve cultures, /sup 3/H-norepinepharine (NE) was taken up in a desipramine blockable fashion and released on exposure to high external K/sup +/ concentrations. NE release was virtually abolished by Co/sup + +/ (3 mM) or in Ca/sup + +/ free media, demonstrating the Ca/sup + +/ dependence of the release. However, the antagonist DHP, nimodipine, was ineffective in blocking transmitter release in concentrations up to 10/sup -5/M. In contrast, the agonist DHP, Bay K8644 (10/sup -6/M), significantly enhanced transmitter release by 35-40% of control. This enhancement was blocked down to control levels by nimodipine (10/sup -6/M). The authors have also demonstrated high affinity /sup 3/H-nitrendipine binding sites (B/sub max/ = 179 fmoles/mg, Kd = 0.25 nM) on these sympathetic neuronal membranes. These data suggest that DHP sensitive Ca/sup + +/ channels, which have been shown to modulate SP release from DRG neurons in culture are not usually involved in NE release from sympathetic neurons. However, prolonged opening of these channels by the DHP agonist, Bay K8644, increases the overall Ca/sup + +/ influx into sympathetic nerves to enhance transmitter release.

  7. Effects of equol on multiple K+ channels stably expressed in HEK 293 cells.

    Science.gov (United States)

    Deng, Xiu-Ling; Wang, Yan; Xiao, Guo-Sheng

    2017-01-01

    The present study investigated the effects of equol on cardiovascular K+ channel currents. The cardiovascular K+ channel currents were determined in HEK 293 cells stably expressing cloned differential cardiovascular K+ channels with conventional whole-cell patch voltage-clamp technique. We found that equol inhibited hKv1.5 (IC50: 15.3 μM), hKv4.3 (IC50: 29.2 μM and 11.9 μM for hKv4.3 peak current and charge area, respectively), IKs (IC50: 24.7 μM) and IhERG (IC50: 31.6 and 56.5 μM for IhERG.tail and IhERG.step, respectively), but not hKir2.1 current, in a concentration-dependent manner. Interestingly, equol increased BKCa current with an EC50 of 0.1 μM. It had no significant effect on guinea pig ventricular action potentials at concentrations of ≤3 μM. These results demonstrate that equol inhibits several cardiac K+ currents at relatively high concentrations, whereas it increases BKCa current at very low concentrations, suggesting that equol is a safe drug candidate for treating patients with cerebral vascular disorders.

  8. Supporting children when providing services to families experiencing multiple problems : Perspectives and evidence on programmes

    NARCIS (Netherlands)

    Knorth, Erik J.; Knot-Dickscheit, Jana; Thoburn, June

    2015-01-01

    Recently, there has been growing interest amongst researchers, practitioners and policy-makers in approaches to understanding and ways of helping parents, children and the communities in which they live to respond to ‘families experiencing multiple problems’ (FEMPs). There is a strong need for

  9. A method for simultaneously delineating multiple targets in 3D-FISH using limited channels, lasers, and fluorochromes.

    Science.gov (United States)

    Zhao, F Y; Yang, X; Chen, D Y; Ma, W Y; Zheng, J G; Zhang, X M

    2014-01-01

    Many studies have suggested a link between the spatial organization of genomes and fundamental biological processes such as genome reprogramming, gene expression, and differentiation. Multicolor fluorescence in situ hybridization on three-dimensionally preserved nuclei (3D-FISH), in combination with confocal microscopy, has become an effective technique for analyzing 3D genome structure and spatial patterns of defined nucleus targets including entire chromosome territories and single gene loci. This technique usually requires the simultaneous visualization of numerous targets labeled with different colored fluorochromes. Thus, the number of channels and lasers must be sufficient for the commonly used labeling scheme of 3D-FISH, "one probe-one target". However, these channels and lasers are usually restricted by a given microscope system. This paper presents a method for simultaneously delineating multiple targets in 3D-FISH using limited channels, lasers, and fluorochromes. In contrast to other labeling schemes, this method is convenient and simple for multicolor 3D-FISH studies, which may result in widespread adoption of the technique. Lastly, as an application of the method, the nucleus locations of chromosome territory 18/21 and centromere 18/21/13 in normal human lymphocytes were analyzed, which might present evidence of a radial higher order chromatin arrangement.

  10. Numerical analysis of the EHD driven flow with heat transfer in a smooth channel using multiple collectors

    Science.gov (United States)

    Taghavi Fadaki, S. S.; Amanifard, N.; Deylami, H. M.; Dolati, F.

    2017-07-01

    In the present study, a new design of collecting electrodes is studied for performing a higher performance in EHD phenomena in a smooth channel. The effect of the electric field on the heat transfer enhancement and swirling flow patterns for a new design of multiple collectors in a smooth channel is numerically investigated with 2-D approach. In this regard, the corona device configuration comprises a single fixed emitting wire situated at the centerline of the channel and different grounded electrode arrangements which are in two types of wire and plate. The results indicate that the multi-collector arrangements cause significant changes in the flow pattern, heat transfer coefficient and friction factor. Furthermore, it is found that the thermal enhancement factor has remarkable growth, and EHD efficiency for two types of wire and plate collectors is notable. Besides, as an outstanding result, the electrohydrodynamic phenomenon has a negative effect on the heat transfer enhancement depending upon the values of Reynolds number and applied electric potential.

  11. Iterative Fusion of Distributed Decisions over the Gaussian Multiple-Access Channel Using Concatenated BCH-LDGM Codes

    Directory of Open Access Journals (Sweden)

    Crespo PedroM

    2011-01-01

    Full Text Available This paper focuses on the data fusion scenario where nodes sense and transmit the data generated by a source to a common destination, which estimates the original information from more accurately than in the case of a single sensor. This work joins the upsurge of research interest in this topic by addressing the setup where the sensed information is transmitted over a Gaussian Multiple-Access Channel (MAC. We use Low Density Generator Matrix (LDGM codes in order to keep the correlation between the transmitted codewords, which leads to an improved received Signal-to-Noise Ratio (SNR thanks to the constructive signal addition at the receiver front-end. At reception, we propose a joint decoder and estimator that exchanges soft information between the LDGM decoders and a data fusion stage. An error-correcting Bose, Ray-Chaudhuri, Hocquenghem (BCH code is further applied suppress the error floor derived from the ambiguity of the MAC channel when dealing with correlated sources. Simulation results are presented for several values of and diverse LDGM and BCH codes, based on which we conclude that the proposed scheme outperforms significantly (by up to 6.3 dB the suboptimum limit assuming separation between Slepian-Wolf source coding and capacity-achieving channel coding.

  12. Oral and craniofacial manifestations of multiple sclerosis: implications for the oral health care provider.

    Science.gov (United States)

    Zhang, G-Q; Meng, Y

    2015-12-01

    Multiple sclerosis is a complex neurological condition affecting sensory and motor nerve transmission. Its progression and symptoms are unpredictable and vary from person to person as well as over time. Symptoms of orofacial pain, trigeminal neuralgia, spasticity, spasms, tremor, fatigue, depression and progressive disability, impact on the individual's ability to maintain oral health, cope with dental treatment and access dental services. Also, many of the medications used in the symptomatic management of the condition have the potential to cause dry mouth and associated oral disease. There is no cure for multiple sclerosis, and treatment focuses on prevention of disability and maintenance of quality of life. The oral health care team plays an essential role in ensuring that oral health impacts positively on general health. This review highlights the epidemiology, etiology, pathophysiology, diagnosis, oral and craniofacial manifestations and their management, and oral health care considerations in patients with MS.

  13. Garnet cannibalism provides clues to extensive hydration of lower crustal fragments in a subduction channel (Sesia Zone, Northwestern Alps)

    Science.gov (United States)

    Giuntoli, Francesco; Lanari, Pierre; Engi, Martin

    2015-04-01

    The extent to which granulites are transformed to eclogites is thought to impose critical limits on the subduction of continental lower crust. Although it is seldom possible to document such densification processes in detail, the transformation is believed to depend on fluid access and deformation. Remarkably complex garnet porphyroblasts are widespread in eclogite facies micaschists in central parts of the Sesia Zone (Western Italian Alps). They occur in polydeformed samples in assemblages involving phengite+quartz+rutile ±paragonite, Na-amphibole, Na-pyroxene, chloritoid. Detailed study of textural and compositional types reveals a rich inventory of growth and partial resorption zones in garnet. These reflect several stages of the polycyclic metamorphic evolution. A most critical observation is that the relict garnet cores indicate growth at 900 °C and 0.9 GPa. This part of the Eclogitic Micaschist Complex thus derived from granulite facies metapelites of Permian age. These dry rocks must have been extensively hydrated during Cretaceous subduction, and garnet records the conditions of these processes. Garnet from micaschist containing rutile, epidote, paragonite and phengite were investigated in detail. Two types of garnet crystals are found in many thin sections: mm-size porphyroclasts and smaller atoll garnets, some 100 µm in diameter. X-ray maps of the porphyroclasts show complex zoning in garnet: a late Paleozoic HT-LP porphyroclastic core is overgrown by several layers of HP-LT Alpine garnet, these show evidence of growth at the expense of earlier garnet generations. Textures indicate 1-2 stages of resorption, with garnet cores that were fractured and then sealed by garnet veins, rimmed by multiple Alpine overgrowth rims with lobate edges. Garnet rim 1 forms peninsula and embayment structures at the expense of the core. Rim 2 surrounds rim 1, both internally and externally, and seems to have grown mainly at the expense of the core. Rim 3 grew mainly at

  14. Multiple Problem-Solving Strategies Provide Insight into Students' Understanding of Open-Ended Linear Programming Problems

    Science.gov (United States)

    Sole, Marla A.

    2016-01-01

    Open-ended questions that can be solved using different strategies help students learn and integrate content, and provide teachers with greater insights into students' unique capabilities and levels of understanding. This article provides a problem that was modified to allow for multiple approaches. Students tended to employ high-powered, complex,…

  15. On the performance of dual-hop systems with multiple antennas: Effects of spatial correlation, keyhole, and co-channel interference

    KAUST Repository

    Yang, Liang

    2012-12-01

    In this paper, taking into account realistic propagation conditions, namely, spatial correlation, keyhole channels, and unequal-power co-channel interference, we investigate the performance of a wireless relay network where all the nodes are equipped with multiple antennas. Considering channel state information assisted amplify-and-forward protocol, we present analytical expressions for the symbol error rate (SER) and outage probability. More specifically, we first derive the SER expressions of a relay system with orthogonal space-time block coding (OSTBC) over correlated/keyhole fading channels. We also analyze the outage probability of interference corrupted relay systems with maximal ratio combing (MRC) at the receiver as well as multiple-input multiple-output MRC (MIMO MRC). Numerical results are given to illustrate and verify the analytical results. © 2012 IEEE.

  16. RESULTS OF REARING THE MULTIPLE AGE GROUPS OF CHANNEL CATFISH (ICTALURUS PUNCTATUS RAFINESQUE WITH THE USE OF PROBIOTIC FEED SUPPLEMENTS NUPRO® AND BIO-MOS®

    Directory of Open Access Journals (Sweden)

    A. Vashchenko

    2015-12-01

    Full Text Available Purpose. To study the effect of feed supplements NUPRO® and BIO-MOS® on the results of rearing the multiple age groups of channel catfish (Ictalurus punctatus Rafinesque. Methodology. The study of effect of feed supplements NUPRO® and BIO-MOS® on the results of rearing the multiple age groups of channel catfish have been carried out according to conventional methods. The experiments were conducted in the conditions of Pridneprovsky industrial fish farm of Dnepropetrovsk region. Channel catfish larvae were reared in standard trays. Water volume in trays was maintained at a level of 1.4 m3, stocking density of larvae was 20 thousand fish/tray. Rearing of young-of-the-year channel catfish was conducted in 1 m3 cages, stocking density of grown up larvae was 1000 fish/m3. Age 1+ channel catfish was reared in 1 m3 cages, stocking density was 150 fish/m3. Findings. The studies demonstrated that feeding of multiple age groups of channel catfish with balanced combined feeds with the addition of feed supplements NUPRO® and BIO-MOS® compared to the control group, which was fed with the combined feed but without supplements, increased their growth intensity. The use of these feed supplements in the combined feed composition contributes to an increase in fish growth rate and fish output and to a reduction in feed costs for fish rearing. The results of the conducted works allow determining the optimum doses of the addition of feed supplements NUPRO® and BIO-MOS® in the composition of combined feeds for feeding multiple age groups of channel catfish reared in the controlled conditions of aquaculture, which are as follow: NUPRO® when added to the feed of channel catfish larvae – 0.5%, young-of-the-year – 3.0%, age-1+ channel catfish – 5.0%; BIO-MOS® for channel catfish larvae – 0.5%, young-of-the-year and age-1+ channel catfish – 5.0%. Hydrochemical parameters in the experimental ponds were within normal limits, temperature regime was

  17. Experiences in simulating and testing coordinated voltage control provided by multiple wind power plants

    Energy Technology Data Exchange (ETDEWEB)

    Arlaban, T.; Alonso, O.; Ortiz, D. [Acciona Windpower S.A. (Spain); Peiro, J.; Rivas, R. [Red Electrica de Espana SAU (Spain); Quinonez-Varela, G.; Lorenzo, P. [Acciona Energia S.A. (Spain)

    2011-07-01

    This document presents some field tests performed in a transmission system node in order to check the adequacy of voltage control performance by multiple wind power plants, with an overall capacity of 395 MW. It briefly explains the Spanish TSO motivation towards new voltage control requirements and the necessity of performing such tests in order to set the most convenient voltage control parameters and to verify the stable operation. It presents how different the voltage control capability between modern wind turbines (DFIG) and older ones (SCIG) specifically retrofitted for voltage control is. (orig.)

  18. Organizational Communication in Emergencies: Using Multiple Channels and Sources to Combat Noise and Capture Attention

    Science.gov (United States)

    Stephens, Keri K.; Barrett, Ashley K.; Mahometa, Michael J.

    2013-01-01

    This study relies on information theory, social presence, and source credibility to uncover what best helps people grasp the urgency of an emergency. We surveyed a random sample of 1,318 organizational members who received multiple notifications about a large-scale emergency. We found that people who received 3 redundant messages coming through at…

  19. Renewal theory for single-molecule systems with multiple reaction channels.

    Science.gov (United States)

    Berezhkovskii, A M

    2011-02-21

    Some single-molecule systems share a common feature: the system performs different cycles returning after each cycle to the same state. In such systems we deal with renewal processes. Examples include (1) single-molecule enzymatic reactions, (2) membrane transport through single-occupancy channels, (3) single-molecule fluorescence spectroscopy, and (4) motion of molecular motors. The paper is focused on the analysis of such systems by means of the renewal theory. To be more specific, the theory of renewal processes is used to study multivariate distribution functions of the numbers of different events in a given observation time. Our main results are simple formulas derived for the Laplace transforms of the distribution functions. General results are illustrated by consideration of several examples.

  20. Study of channels and margins of milk commercialization at the highlands zone of Sugamuxi providence (Department of Boyacá

    Directory of Open Access Journals (Sweden)

    Paulo Rodríguez Romero

    2005-05-01

    Full Text Available The objective of the present study is to give information about the milk marketing characteristics in Sugamuxi province. The commercialization channels were identified and the commercial agents’ participation margins were established along with the current state of the links that form the production chain. Furthermore, the diffusion and application of the Treaty of Competitiveness of the Milk Sector (ACCL and of its system of prices were evaluated. This analysis discovered problems in two clearly defined areas based on topographical conditions (plain and hillside areas. They each present different problems and use different commercialisation channels. For this reason 235 surveys were given to the different links of the chain in each area. The commercialisation channel in plain areas is: producer, regional processors, wholesaler, consumer, and in hillside areas: producer, transporters, regional processor, local distributor and consumer. The commercialisation margins were calculated for raw milk, pasteurised milk and cheese. Because the profits are greater the great majority of producers in the plain areas are not applying the prices system. Furthermore, there is deficient knowledge of the ACCL on the part of the other links of the chain. Added to the small amount of information about the milk sector and the regional participants the development of a national competitive milk chain is blocked.

  1. Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability.

    Science.gov (United States)

    Böhm, J; Scherzer, S; Shabala, S; Krol, E; Neher, E; Mueller, T D; Hedrich, R

    2016-03-07

    The animal diet of the carnivorous Venus flytrap, Dionaea muscipula, contains a sodium load that enters the capture organ via an HKT1-type sodium channel, expressed in special epithelia cells on the inner trap lobe surface. DmHKT1 expression and sodium uptake activity is induced upon prey contact. Here, we analyzed the HKT1 properties required for prey sodium osmolyte management of carnivorous Dionaea. Analyses were based on homology modeling, generation of model-derived point mutants, and their functional testing in Xenopus oocytes. We showed that the wild-type HKT1 and its Na(+)- and K(+)-permeable mutants function as ion channels rather than K(+) transporters driven by proton or sodium gradients. These structural and biophysical features of a high-capacity, Na(+)-selective ion channel enable Dionaea glands to manage prey-derived sodium loads without confounding the action potential-based information management of the flytrap. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  2. Channel Power in Multi-Channel Environments

    NARCIS (Netherlands)

    M.G. Dekimpe (Marnik); B. Skiera (Bernd)

    2004-01-01

    textabstractIn the literature, little attention has been paid to instances where companies add an Internet channel to their direct channel portfolio. However, actively managing multiple sales channels requires knowing the customers’ channel preferences and the resulting channel power. Two key

  3. Social demand for multiple benefits provided by Aleppo pine forest management in Catalonia, Spain

    DEFF Research Database (Denmark)

    Varela, Elsa; Jacobsen, Jette Bredahl; Mavsar, Robert

    2017-01-01

    This paper estimates the social demand for key benefits provided by Aleppo pine forests in Catalonia that can be enhanced by management. These so-called externalities are the side effects of forest management on citizens’ welfare and can be either positive or negative. The externalities addressed...

  4. Multi-channel EEG-based sleep stage classification with joint collaborative representation and multiple kernel learning.

    Science.gov (United States)

    Shi, Jun; Liu, Xiao; Li, Yan; Zhang, Qi; Li, Yingjie; Ying, Shihui

    2015-10-30

    Electroencephalography (EEG) based sleep staging is commonly used in clinical routine. Feature extraction and representation plays a crucial role in EEG-based automatic classification of sleep stages. Sparse representation (SR) is a state-of-the-art unsupervised feature learning method suitable for EEG feature representation. Collaborative representation (CR) is an effective data coding method used as a classifier. Here we use CR as a data representation method to learn features from the EEG signal. A joint collaboration model is established to develop a multi-view learning algorithm, and generate joint CR (JCR) codes to fuse and represent multi-channel EEG signals. A two-stage multi-view learning-based sleep staging framework is then constructed, in which JCR and joint sparse representation (JSR) algorithms first fuse and learning the feature representation from multi-channel EEG signals, respectively. Multi-view JCR and JSR features are then integrated and sleep stages recognized by a multiple kernel extreme learning machine (MK-ELM) algorithm with grid search. The proposed two-stage multi-view learning algorithm achieves superior performance for sleep staging. With a K-means clustering based dictionary, the mean classification accuracy, sensitivity and specificity are 81.10 ± 0.15%, 71.42 ± 0.66% and 94.57 ± 0.07%, respectively; while with the dictionary learned using the submodular optimization method, they are 80.29 ± 0.22%, 71.26 ± 0.78% and 94.38 ± 0.10%, respectively. The two-stage multi-view learning based sleep staging framework outperforms all other classification methods compared in this work, while JCR is superior to JSR. The proposed multi-view learning framework has the potential for sleep staging based on multi-channel or multi-modality polysomnography signals. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.

    Science.gov (United States)

    Inserra, Marco C; Israel, Mathilde R; Caldwell, Ashlee; Castro, Joel; Deuis, Jennifer R; Harrington, Andrea M; Keramidas, Angelo; Garcia-Caraballo, Sonia; Maddern, Jessica; Erickson, Andelain; Grundy, Luke; Rychkov, Grigori Y; Zimmermann, Katharina; Lewis, Richard J; Brierley, Stuart M; Vetter, Irina

    2017-02-22

    Human intoxication with the seafood poison ciguatoxin, a dinoflagellate polyether that activates voltage-gated sodium channels (NaV), causes ciguatera, a disease characterised by gastrointestinal and neurological disturbances. We assessed the activity of the most potent congener, Pacific ciguatoxin-1 (P-CTX-1), on NaV1.1-1.9 using imaging and electrophysiological approaches. Although P-CTX-1 is essentially a non-selective NaV toxin and shifted the voltage-dependence of activation to more hyperpolarising potentials at all NaV subtypes, an increase in the inactivation time constant was observed only at NaV1.8, while the slope factor of the conductance-voltage curves was significantly increased for NaV1.7 and peak current was significantly increased for NaV1.6. Accordingly, P-CTX-1-induced visceral and cutaneous pain behaviours were significantly decreased after pharmacological inhibition of NaV1.8 and the tetrodotoxin-sensitive isoforms NaV1.7 and NaV1.6, respectively. The contribution of these isoforms to excitability of peripheral C- and A-fibre sensory neurons, confirmed using murine skin and visceral single-fibre recordings, reflects the expression pattern of NaV isoforms in peripheral sensory neurons and their contribution to membrane depolarisation, action potential initiation and propagation.

  6. Achievable Rate of Spectrum Sharing Cognitive Radio Multiple-Antenna Channels

    KAUST Repository

    Sboui, Lokman

    2015-04-28

    We investigate the spectral efficiency gain of an uplink Cognitive Radio (CR) Multi-Input-Multi-Output system in which the Secondary User (SU) is allowed to share the spectrum with the Primary User (PU) using a specific precoding scheme to communicate with a common receiver. The proposed scheme exploits, at the same time, the free eigenmodes of the primary channel after a space alignment procedure and the interference threshold tolerated by the PU. At the common receiver, we adopt a Successive Interference Cancellation (SIC) technique to eliminate the effect of the detected primary signal transmitted through the exploited eigenmodes. Furthermore, we analyze the SIC operation inaccuracy as well as the CSI estimation imperfection on the PU and SU throughputs. Numerical results show that our proposed scheme enhances considerably the cognitive achievable rate. For instance, in case of a perfect detection of the PU signal, the CR rate remains non-zero for high Signal to Noise Ratio which is usually impossible when we only employ a space alignment technique. We show that a modified water-filling power allocation policy at the PU can increase the secondary rate with a marginal degradation of the primary rate. Finally, we investigate the behavior of the PU and SU rates through the study of the rate achievable region.

  7. An Overview of High-performance Parallel Big Data transfers over multiple network channels with Transport Layer Security (TLS) and TLS plus Perfect Forward Secrecy (PFS)

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Chin [SLAC National Accelerator Lab., Menlo Park, CA (United States); Corttrell, R. A. [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-05-06

    This Technical Note provides an overview of high-performance parallel Big Data transfers with and without encryption for data in-transit over multiple network channels. It shows that with the parallel approach, it is feasible to carry out high-performance parallel "encrypted" Big Data transfers without serious impact to throughput. But other impacts, e.g. the energy-consumption part should be investigated. It also explains our rationales of using a statistics-based approach for gaining understanding from test results and for improving the system. The presentation is of high-level nature. Nevertheless, at the end we will pose some questions and identify potentially fruitful directions for future work.

  8. Multi-slice echo-planar spectroscopic MR imaging provides both global and local metabolite measures in multiple sclerosis

    DEFF Research Database (Denmark)

    Mathiesen, Henrik Kahr; Tscherning, Thomas; Sorensen, Per Soelberg

    2005-01-01

    MR spectroscopy (MRS) provides information about neuronal loss or dysfunction by measuring decreases in N-acetyl aspartate (NAA), a metabolite widely believed to be a marker of neuronal viability. In multiple sclerosis (MS), whole-brain NAA (WBNAA) has been suggested as a marker of disease progre...

  9. Novel Control Strategy for Multiple Run-of-the-River Hydro Power Plants to Provide Grid Ancillary Services

    Energy Technology Data Exchange (ETDEWEB)

    Mohanpurkar, Manish; Luo, Yusheng; Hovsapian, Rob; Muljadi, Eduard; Gevorgian, Vahan; Koritarov, Vladimir

    2017-05-01

    Electricity generated by Hydropower Plants (HPPs) contributes a considerable portion of bulk electricity generation and delivers it with a low carbon footprint. In fact, HPP electricity generation provides the largest share from renewable energy resources, which includes solar and wind energy. The increasing penetration of wind and solar penetration leads to a lowered inertia in the grid and hence poses stability challenges. In recent years, breakthrough in energy storage technologies have demonstrated the economic and technical feasibility of extensive deployments in power grids. Multiple ROR HPPs if integrated with scalable, multi time-step energy storage so that the total output can be controlled. Although, the size of a single energy storage is far smaller than that of a typical reservoir, cohesively managing multiple sets of energy storage distributed in different locations is proposed. The ratings of storages and multiple ROR HPPs approximately equals the rating of a large, conventional HPP. The challenges associated with the system architecture and operation are described. Energy storage technologies such as supercapacitors, flywheels, batteries etc. can function as a dispatchable synthetic reservoir with a scalable size of energy storage will be integrated. Supercapacitors, flywheels, and battery are chosen to provide fast, medium, and slow responses to support grid requirements. Various dynamic and transient power grid conditions are simulated and performances of integrated ROR HPPs with energy storage is provided. The end goal of this research is to investigate the inertial equivalence of a large, conventional HPP with a unique set of multiple ROR HPPs and optimally rated energy storage systems.

  10. Evaluation channel performance in multichannel environments

    NARCIS (Netherlands)

    Gensler, S.; Dekimpe, M.; Skiera, B.

    2007-01-01

    Evaluating channel performance is crucial for actively managing multiple sales channels, and requires understanding the customers' channel preferences. Two key components of channel performance are (i) the existing customers' intrinsic loyalty to a particular channel and (ii) the channel's ability

  11. Improved power-law estimates from multiple samples provided by millennium climate simulations

    Science.gov (United States)

    Henriksson, S. V.; Räisänen, P.; Silen, J.; Järvinen, H.; Laaksonen, A.

    2015-02-01

    Using the long annual mean temperature time series provided by millennium Earth System Model simulations and a method of discrete Fourier transform with varying starting point and length of time window together with averaging, we get good fits to power laws between two characteristic oscillatory timescales of the model climate: multidecadal (50-80 years) and El Nino (3-6 years) timescales. For global mean temperature, we fit β ˜ 0.35 in a relation S( f) ˜ f - β in a simulation without external climate forcing and β over 0.7 in a simulation with external forcing included. The power law is found both with and without external forcing despite the forcings, e.g. the volcanic forcing, not showing similar behaviour, indicating a nonlinear temperature response to time-varying forcing. We also fit a power law with β ˜ 8 to the narrow frequency range between El Nino frequencies (up to 1/(3.2 years)) and the Nyquist frequency (1/(2 years)). Also, monthly mean temperature time series are considered and a decent power-law fit for frequencies above 1/year is obtained. Regional variability in best-fit β is explored, and the impact of choosing the frequency range on the result is illustrated. When all resolved frequencies are used, land areas seem to have lower βs than ocean areas on average, but when fits are restricted to frequencies below 1/(6 years), this difference disappears, while regional differences still remain. Results compare well with measurements both for global mean temperature and for the central England temperature record.

  12. Multiple Source Biosimilar Insulin, What’s a Provider to Do?

    Science.gov (United States)

    2014-01-01

    In the United States the FDA designates generic products that are bioequivalent as AB substitutable (FDA rating signifying the approved application contains adequate scientific evidence establishing through in vivo and/or in vitro studies the bioequivalence of the product to a selected reference product) and are expected to produce the same therapeutic results as the innovator product. In the case of biological proteins that are similar to already approved innovator biologicals, such as recombinant human insulin, the insulin molecule and accompanying secondary and tertiary structures will differ between manufacturing sources. Even subtle differences between innovator (branded) and alternative “biosimilar” products may produce different therapeutic endpoints. Substitution of a branded insulin with a biosimilar insulin product may result in more, less, or equal therapeutic response making in difficult for the practitioner to assess glycemic control between patient follow-up visits. Significant therapeutic difference is possible, which could result in mild to severe hypoglycemia reaction or hyperglycemia induced tissue damage. Slight molecular changes along with different accompanying proteins, protein fragments, and other naturally occurring contaminants theoretically increase odds of insulin resistance or allergic reaction. Current review of medication product and device quality relies on manufacturer self-oversight and individual reporting of product adverse events after use. While this is usually sufficient for oral medications and many medical devices, critical use products such as sterile products, biosimilar insulin, insulin delivery devices, self-monitoring blood glucose monitoring systems, and test strips require much more vigorous oversight to prevent individual and/or large scale catastrophe. Health care providers should advocate for their patient to have access to affordable, consistent, quality-assured products to effectively and safely manage their

  13. Statistics of α-μ Random Variables and Their Applications inWireless Multihop Relaying and Multiple Scattering Channels

    KAUST Repository

    Wang, Kezhi

    2015-06-01

    Exact results for the probability density function (PDF) and cumulative distribution function (CDF) of the sum of ratios of products (SRP) and the sum of products (SP) of independent α-μ random variables (RVs) are derived. They are in the form of 1-D integral based on the existing works on the products and ratios of α-μ RVs. In the derivation, generalized Gamma (GG) ratio approximation (GGRA) is proposed to approximate SRP. Gamma ratio approximation (GRA) is proposed to approximate SRP and the ratio of sums of products (RSP). GG approximation (GGA) and Gamma approximation (GA) are used to approximate SP. The proposed results of the SRP can be used to calculate the outage probability (OP) for wireless multihop relaying systems or multiple scattering channels with interference. The proposed results of the SP can be used to calculate the OP for these systems without interference. In addition, the proposed approximate result of the RSP can be used to calculate the OP of the signal-To-interference ratio (SIR) in a multiple scattering system with interference. © 1967-2012 IEEE.

  14. H2O2augments cytosolic calcium in nucleus tractus solitarii neurons via multiple voltage-gated calcium channels.

    Science.gov (United States)

    Ostrowski, Tim D; Dantzler, Heather A; Polo-Parada, Luis; Kline, David D

    2017-05-01

    Reactive oxygen species (ROS) play a profound role in cardiorespiratory function under normal physiological conditions and disease states. ROS can influence neuronal activity by altering various ion channels and transporters. Within the nucleus tractus solitarii (nTS), a vital brainstem area for cardiorespiratory control, hydrogen peroxide (H 2 O 2 ) induces sustained hyperexcitability following an initial depression of neuronal activity. The mechanism(s) associated with the delayed hyperexcitability are unknown. Here we evaluate the effect(s) of H 2 O 2 on cytosolic Ca 2+ (via fura-2 imaging) and voltage-dependent calcium currents in dissociated rat nTS neurons. H 2 O 2 perfusion (200 µM; 1 min) induced a delayed, slow, and moderate increase (~27%) in intracellular Ca 2+ concentration ([Ca 2+ ] i ). The H 2 O 2 -mediated increase in [Ca 2+ ] i prevailed during thapsigargin, excluding the endoplasmic reticulum as a Ca 2+ source. The effect, however, was abolished by removal of extracellular Ca 2+ or the addition of cadmium to the bath solution, suggesting voltage-gated Ca 2+ channels (VGCCs) as targets for H 2 O 2 modulation. Recording of the total voltage-dependent Ca 2+ current confirmed H 2 O 2 enhanced Ca 2+ entry. Blocking VGCC L, N, and P/Q subtypes decreased the number of cells and their calcium currents that respond to H 2 O 2 The number of responder cells to H 2 O 2 also decreased in the presence of dithiothreitol, suggesting the actions of H 2 O 2 were dependent on sulfhydryl oxidation. In summary, here, we have shown that H 2 O 2 increases [Ca 2+ ] i and its Ca 2+ currents, which is dependent on multiple VGCCs likely by oxidation of sulfhydryl groups. These processes presumably contribute to the previously observed delayed hyperexcitability of nTS neurons in in vitro brainstem slices. Copyright © 2017 the American Physiological Society.

  15. Polymer electrolytes with multiple conductive channels prepared from NBR/SBR latex films impregnated with lithium salt and plasticizer

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Morihiko; Rutt, J.S.; Nishi, Shiro [Nippon Telegraph and Telephone Corp., Musashino, Tokyo (Japan)

    1995-09-01

    Polymer electrolytes, composed of a polar polymer acting as a host matrix for lithium-salt solutions, have high ionic conductivity and have been studied for application in advanced electronic devices such as the rechargeable lithium battery. Polymer electrolytes with high ionic conductivity (> 10{sup {minus}3} S/cm) and good tensile strength were prepared by swelling poly(acrylonitrile-co-butadiene) (NBR)/poly(styrene-co-butadiene) (SBR)/LiClO{sub 4} latex films with {gamma}-butyrolactone ({gamma}-BL) or LiClO{sub 4}/{gamma}-BL plasticizer. Before swelling, the LiClO{sub 4} phase is formed at the particle interface. After politicization, two ion-conductive channels are present: the LiClO{sub 4} phase is present at the interface of the latex particles, and the NBR phase is formed from NBR latex particles. These regions are polar and impregnated selectively with polar {gamma}-BL solvent or LiClO{sub 4}/{gamma}-BL solution, building primary and secondary ion-conductive channels, respectively. The SBR phase (formed from SBR latex particles) is nonpolar and not impregnated, providing a mechanically supportive matrix. High ionic conductivity on the order of 10{sup {minus}3} S/cm is achieved when NBR/SBR(50/50)/LiClO{sub 4} latex film was saturated on 0.2 to 0.4M LiClO{sub 4}/{gamma}-BL solutions. Various microscopic and macroscopic analyses suggest that two types of ion-conductive channels exist in the polymer electrolyte film.

  16. Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis?

    DEFF Research Database (Denmark)

    Madsen, Lars Siim; Christophersen, Palle; Olesen, Søren-Peter

    2005-01-01

    (+) channel (the IK channel encoded by the KCNN4 gene) prevents cytokine production in the spinal chord and ameliorates the development of EAE caused by injection of myelin oligodendrocyte glycoprotein (MOG)(35-55) in mice. These data renew the focus on the IK channel as a potential target for the development...... of new immune-suppressant drugs for the treatment of autoimmune diseases....

  17. Novel Control Strategy for Multiple Run-of-the-River Hydro Power Plants to Provide Grid Ancillary Services

    Energy Technology Data Exchange (ETDEWEB)

    Mohanpurkar, Manish; Luo, Yusheng; Hovsapian, Rob; Muljadi, Eduard; Gevorgian, Vahan; Koritarov, Vladimir

    2017-07-12

    Hydropower plant (HPP) generation comprises a considerable portion of bulk electricity generation and is delivered with a low-carbon footprint. In fact, HPP electricity generation provides the largest share from renewable energy resources, which include wind and solar. Increasing penetration levels of wind and solar lead to a lower inertia on the electric grid, which poses stability challenges. In recent years, breakthroughs in energy storage technologies have demonstrated the economic and technical feasibility of extensive deployments of renewable energy resources on electric grids. If integrated with scalable, multi-time-step energy storage so that the total output can be controlled, multiple run-of-the-river (ROR) HPPs can be deployed. Although the size of a single energy storage system is much smaller than that of a typical reservoir, the ratings of storages and multiple ROR HPPs approximately equal the rating of a large, conventional HPP. This paper proposes cohesively managing multiple sets of energy storage systems distributed in different locations. This paper also describes the challenges associated with ROR HPP system architecture and operation.

  18. Closure of multiple types of K+ channels is necessar to induce changes in renal vascular resistance in vivo in rats

    DEFF Research Database (Denmark)

    Sørensen, Charlotte Mehlin; Giese, Isaiah; Braunstein, Thomas Hartig

    2011-01-01

    reduction. The effect of the cocktail of K(+) channel blockers was confirmed in mice using the isolated blood-perfused juxtamedullary nephron preparation. A cocktail of K(+) channel openers (K(+), NS309, NS1619 and pinacidil) had only a minor effect on baseline RBF in vivo in rats, but reduced......Inhibition of K(+) channels might mediate renal vasoconstriction. As inhibition of a single type of K(+) channel caused minor or no renal vasoconstriction in vivo in rats, we hypothesized that several classes of K(+) channels must be blocked to elicit renal vasoconstriction. We measured renal blood...... flow (RBF) in vivo in anesthetized Sprague-Dawley rats. Test agents were infused directly into the renal artery to avoid systemic effects. Inhibition of BK(Ca) and K(ir) channels (with TEA and Ba(2+), respectively) caused small and transient reductions in RBF (to 93¿±¿2% and 95¿±¿1% of baseline...

  19. A Low-Complexity LMMSE Channel Estimation Method for OFDM-Based Cooperative Diversity Systems with Multiple Amplify-and-Forward Relays

    Directory of Open Access Journals (Sweden)

    Yan Kai

    2008-01-01

    Full Text Available Orthogonal frequency division multiplexing- (OFDM- based amplify-and-forward (AF cooperative communication is an effective way for single-antenna systems to exploit the spatial diversity gains in frequency-selective fading channels, but the receiver usually requires the knowledge of the channel state information to recover the transmitted signals. In this paper, a training-sequences-aided linear minimum mean square error (LMMSE channel estimation method is proposed for OFDM-based cooperative diversity systems with multiple AF relays over frequency-selective fading channels. The mean square error (MSE bound on the proposed method is derived and the optimal training scheme with respect to this bound is also given. By exploiting the optimal training scheme, an optimal low-rank LMMSE channel estimator is introduced to reduce the computational complexity of the proposed method via singular value decomposition. Furthermore, the Chu sequence is employed as the training sequence to implement the optimal training scheme with easy realization at the source terminal and reduced computational complexity at the relay terminals. The performance of the proposed low-complexity channel estimation method and the superiority of the derived optimal training scheme are verified through simulation results.

  20. A Low-Complexity LMMSE Channel Estimation Method for OFDM-Based Cooperative Diversity Systems with Multiple Amplify-and-Forward Relays

    Directory of Open Access Journals (Sweden)

    Haitao Liu

    2008-07-01

    Full Text Available Orthogonal frequency division multiplexing- (OFDM- based amplify-and-forward (AF cooperative communication is an effective way for single-antenna systems to exploit the spatial diversity gains in frequency-selective fading channels, but the receiver usually requires the knowledge of the channel state information to recover the transmitted signals. In this paper, a training-sequences-aided linear minimum mean square error (LMMSE channel estimation method is proposed for OFDM-based cooperative diversity systems with multiple AF relays over frequency-selective fading channels. The mean square error (MSE bound on the proposed method is derived and the optimal training scheme with respect to this bound is also given. By exploiting the optimal training scheme, an optimal low-rank LMMSE channel estimator is introduced to reduce the computational complexity of the proposed method via singular value decomposition. Furthermore, the Chu sequence is employed as the training sequence to implement the optimal training scheme with easy realization at the source terminal and reduced computational complexity at the relay terminals. The performance of the proposed low-complexity channel estimation method and the superiority of the derived optimal training scheme are verified through simulation results.

  1. Value co-creation through multiple shopping channels: The interconnections with social exclusion and well-being

    OpenAIRE

    Dennis, Charles; Bourlaskis, Michael; Alamanos, Eleftherios; Papagiannidis, Savvas; Brakus, J. Joško

    2017-01-01

    This study examines consumers’ value co-creation via several shopping channels including a traditional out-of-home shopping channel and “smart” channels where consumers use a computer, a mobile phone, or social media. It focuses on the effect that value co-creation has on consumers’ shopping behavior as well as on the perceived contribution of a shopping channel to their well-being, with a focus on individuals who perceive themselves as being socially excluded, particularly by mobility disabi...

  2. Improving virtual channel discrimination in a multi-channel context.

    Science.gov (United States)

    Srinivasan, Arthi G; Shannon, Robert V; Landsberger, David M

    2012-04-01

    Improving spectral resolution in cochlear implants is key to improving performance in difficult listening conditions (e.g. speech in noise, music, etc.). Current focusing might reduce channel interaction, thereby increasing spectral resolution. Previous studies have shown that combining current steering and current focusing reduces spread of excitation and improves virtual channel discrimination in a single-channel context. It is unclear whether the single-channel benefits from current focusing extend to a multi-channel context, in which the physical and perceptual interference of multiple stimulated channels might overwhelm the benefits of improved spectral resolution. In this study, signal discrimination was measured with and without current focusing, in the presence of competing stimuli on nearby electrodes. Results showed that signal discrimination was consistently better with current focusing than without, regardless of the amplitude of the competing stimuli. Therefore, combining current steering and current focusing may provide more effective spectral cues than are currently available.

  3. Assimilative model for ionospheric dynamics employing delay, Doppler, and direction of arrival measurements from multiple HF channels

    Science.gov (United States)

    Fridman, Sergey V.; Nickisch, L. J.; Hausman, Mark; Zunich, George

    2016-03-01

    We describe the development of new HF data assimilation capabilities for our ionospheric inversion algorithm called GPSII (GPS Ionospheric Inversion). Previously existing capabilities of this algorithm included assimilation of GPS total electron content data as well as assimilation of backscatter ionograms. In the present effort we concentrated on developing assimilation tools for data related to HF propagation channels. Measurements of propagation delay, angle of arrival, and the ionosphere-induced Doppler from any number of known propagation links can now be utilized by GPSII. The resulting ionospheric model is consistent with all assimilated measurements. This means that ray tracing simulations of the assimilated propagation links are guaranteed to be in agreement with measured data within the errors of measurement. The key theoretical element for assimilating HF data is the raypath response operator (RPRO) which describes response of raypath parameters to infinitesimal variations of electron density in the ionosphere. We construct the RPRO out of the fundamental solution of linearized ray tracing equations for a dynamic magnetoactive plasma. We demonstrate performance and internal consistency of the algorithm using propagation delay data from multiple oblique ionograms (courtesy of Defence Science and Technology Organisation, Australia) as well as with time series of near-vertical incidence sky wave data (courtesy of the Intelligence Advanced Research Projects Activity HFGeo Program Government team). In all cases GPSII produces electron density distributions which are smooth in space and in time. We simulate the assimilated propagation links by performing ray tracing through GPSII-produced ionosphere and observe that simulated data are indeed in agreement with assimilated measurements.

  4. Estimation of human circadian phase via a multi-channel ambulatory monitoring system and a multiple regression model.

    Science.gov (United States)

    Kolodyazhniy, Vitaliy; Späti, Jakub; Frey, Sylvia; Götz, Thomas; Wirz-Justice, Anna; Kräuchi, Kurt; Cajochen, Christian; Wilhelm, Frank H

    2011-02-01

    Reliable detection of circadian phase in humans using noninvasive ambulatory measurements in real-life conditions is challenging and still an unsolved problem. The masking effects of everyday behavior and environmental input such as physical activity and light on the measured variables need to be considered critically. Here, we aimed at developing techniques for estimating circadian phase with the lowest subject burden possible, that is, without the need of constant routine (CR) laboratory conditions or without measuring the standard circadian markers, (rectal) core body temperature (CBT), and melatonin levels. In this validation study, subjects (N = 16) wore multi-channel ambulatory monitoring devices and went about their daily routine for 1 week. The devices measured a large number of physiological, behavioral, and environmental variables, including CBT, skin temperatures, cardiovascular and respiratory function, movement/posture, ambient temperature, and the spectral composition and intensity of light received at eye level. Sleep diaries were logged electronically. After the ambulatory phase, subjects underwent a 32-h CR procedure in the laboratory for measuring unmasked circadian phase based on the "midpoint" of the salivary melatonin profile. To overcome the complex masking effects of confounding variables during ambulatory measurements, multiple regression techniques were applied in combination with the cross-validation approach to subject-independent prediction of circadian phase. The most accurate estimate of circadian phase was achieved using skin temperatures, irradiance for ambient light in the blue spectral band, and motion acceleration as predictors with lags of up to 24 h. Multiple regression showed statistically significant improvement of variance of prediction error over the traditional approaches to determining circadian phase based on single predictors (motion acceleration or sleep log), although CBT was intentionally not included as the predictor

  5. Development and comparison of multiple regression models to predict bankfull channel dimensions for use in hydrologic models

    Science.gov (United States)

    Bankfull hydraulic geometry relationships are used to estimate channel dimensions for streamflow simulation models, which require channel geometry data as input parameters. Often, one nationwide curve is used across the entire United States (U.S.) (e.g., in Soil and Water Assessment Tool), even tho...

  6. TREK-1 (K2P2.1) K+ channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control.

    Science.gov (United States)

    Lugenbiel, Patrick; Wenz, Fabian; Syren, Pascal; Geschwill, Pascal; Govorov, Katharina; Seyler, Claudia; Frank, Derk; Schweizer, Patrick A; Franke, Jennifer; Weis, Tanja; Bruehl, Claus; Schmack, Bastian; Ruhparwar, Arjang; Karck, Matthias; Frey, Norbert; Katus, Hugo A; Thomas, Dierk

    2017-01-01

    Atrial fibrillation (AF) is the most common cardiac arrhythmia. Concomitant heart failure (HF) poses a particular therapeutic challenge and is associated with prolonged atrial electrical refractoriness compared with non-failing hearts. We hypothesized that downregulation of atrial repolarizing TREK-1 (K2P2.1) K+ channels contributes to electrical remodeling during AF with HF, and that TREK-1 gene transfer would provide rhythm control via normalization of atrial effective refractory periods in this AF subset. In patients with chronic AF and HF, atrial TREK-1 mRNA levels were reduced by 82% (left atrium) and 81% (right atrium) compared with sinus rhythm (SR) subjects. Human findings were recapitulated in a porcine model of atrial tachypacing-induced AF and reduced left ventricular function. TREK-1 mRNA (-66%) and protein (-61%) was suppressed in AF animals at 14-day follow-up compared with SR controls. Downregulation of repolarizing TREK-1 channels was associated with prolongation of atrial effective refractory periods versus baseline conditions, consistent with prior observations in humans with HF. In a preclinical therapeutic approach, pigs were randomized to either atrial Ad-TREK-1 gene therapy or sham treatment. Gene transfer effectively increased TREK-1 protein levels and attenuated atrial effective refractory period prolongation in the porcine AF model. Ad-TREK-1 increased the SR prevalence to 62% during follow-up in AF animals, compared to 35% in the untreated AF group. In conclusion, TREK-1 downregulation and rhythm control by Ad-TREK-1 transfer suggest mechanistic and potential therapeutic significance of TREK-1 channels in a subgroup of AF patients with HF and prolonged atrial effective refractory periods. Functional correction of ionic remodeling through TREK-1 gene therapy represents a novel paradigm to optimize and specify AF management.

  7. Molecular pharmacology of the calcium channel: evidence for subtypes, multiple drug-receptor sites, channel subunits, and the development of a radioiodinated 1,4-dihydropyridine calcium channel label, (/sup 125/I)iodipine

    Energy Technology Data Exchange (ETDEWEB)

    Glossmann, H.; Ferry, D.R.; Goll, A.; Rombusch, M.

    1984-01-01

    Radiolabeled Ca2+ antagonists (1,4-dihydropyridines, verapamil, and D-cis-diltiazem) were used to study voltage-operated Ca2+ channels in different excitable tissues. The concept of three subtypes of Ca2+ channels, represented by brain, heart, and skeletal-muscle isoreceptors for 1,4-dihydropyridines, is developed. The three subtypes are characterized by a variety of criteria. Despite the biochemical differences between the subtypes, they have the same Mr in situ by target-size analysis (Mr approximately equal to 180,000, when evaluated by (/sub 3/H)nimodipine). The concept of the metalloprotein nature of the channel and the interaction of channel drugs with the Me2+ binding sites of the ionic pore is demonstrated. Distinct but interacting drug-receptor sites of the Ca2+ channel are found by direct labeling as well as indirectly by drug competition studies. The authors distinguish between the 1,4-dihydropyridine site, the verapamil site, and the D-cis-diltiazem site. Each receptor site can exist in high and low-affinity state; the distribution of receptor sites in these states is regulated by temperature, ions, and drugs. The concept of intrinsic activity of drugs to stabilize the high-affinity state is exemplified for the 1,4-dihydropyridines. A change in the channel architecture is induced by binding of D-cis-diltiazem to its drug receptor site. This is proven by target-size analysis of the channel in situ. Partially purified t-tubule membranes from skeletal muscle are an extremely rich source of Ca2+ channel drug-receptor sites. The stoichiometry was determined in this preparation and found to be four verapamil:two 1,4-dihydropyridine:one D-cis-diltiazem site. A novel Ca2+ channel probe, (/sup 125/I)iodipine (2,200 Ci/mmol), was synthetized, and the properties of this ligand are presented.

  8. Global Clear-Sky Surface Skin Temperature from Multiple Satellites Using a Single-Channel Algorithm with Angular Anisotropy Corrections

    Science.gov (United States)

    Scarino, Benjamin R.; Minnis, Patrick; Chee, Thad; Bedka, Kristopher M.; Yost, Christopher R.; Palikonda, Rabindra

    2017-01-01

    Surface skin temperature (T(sub s)) is an important parameter for characterizing the energy exchange at the ground/water-atmosphere interface. The Satellite ClOud and Radiation Property retrieval System (SatCORPS) employs a single-channel thermal-infrared (TIR) method to retrieve T(sub s) over clear-sky land and ocean surfaces from data taken by geostationary Earth orbit (GEO) and low Earth orbit (LEO) satellite imagers. GEO satellites can provide somewhat continuous estimates of T(sub s) over the diurnal cycle in non-polar regions, while polar T(sub s) retrievals from LEO imagers, such as the Advanced Very High Resolution Radiometer (AVHRR), can complement the GEO measurements. The combined global coverage of remotely sensed T(sub s), along with accompanying cloud and surface radiation parameters, produced in near-realtime and from historical satellite data, should be beneficial for both weather and climate applications. For example, near-realtime hourly T(sub s) observations can be assimilated in high-temporal-resolution numerical weather prediction models and historical observations can be used for validation or assimilation of climate models. Key drawbacks to the utility of TIR-derived T(sub s) data include the limitation to clear-sky conditions, the reliance on a particular set of analyses/reanalyses necessary for atmospheric corrections, and the dependence on viewing and illumination angles. Therefore, T(sub s) validation with established references is essential, as is proper evaluation of T(sub s) sensitivity to atmospheric correction source. This article presents improvements on the NASA Langley GEO satellite and AVHRR TIR-based T(sub s) product that is derived using a single-channel technique. The resulting clear-sky skin temperature values are validated with surface references and independent satellite products. Furthermore, an empirically adjusted theoretical model of satellite land surface temperature (LST) angular anisotropy is tested to improve

  9. REVIEW OF WIRELESS MIMO CHANNEL MODELS | Anioke ...

    African Journals Online (AJOL)

    The need to increase spectral efficiency has led to the design of multiple antenna systems for both transmit and receive sides otherwise known as MIMO. Channel modeling forms an integral part of this design. Therefore it is very important to investigate and understand existing MIMO channel models. This paper provides a ...

  10. MP2RAGE provides new clinically-compatible correlates of mild cognitive deficits in relapsing-remitting multiple sclerosis.

    Science.gov (United States)

    Simioni, Samanta; Amarù, Fabio; Bonnier, Guillaume; Kober, Tobias; Rotzinger, David; Du Pasquier, Renaud; Schluep, Myriam; Meuli, Reto; Sbarbati, Andrea; Thiran, Jean-Philippe; Krueger, Gunnar; Granziera, Cristina

    2014-08-01

    Despite that cognitive impairment is a known early feature present in multiple sclerosis (MS) patients, the biological substrate of cognitive deficits in MS remains elusive. In this study, we assessed whether T1 relaxometry, as obtained in clinically acceptable scan times by the recent Magnetization Prepared 2 Rapid Acquisition Gradient Echoes (MP2RAGE) sequence, may help identifying the structural correlate of cognitive deficits in relapsing-remitting MS patients (RRMS). Twenty-nine healthy controls (HC) and forty-nine RRMS patients underwent high-resolution 3T magnetic resonance imaging to obtain optimal cortical lesion (CL) and white matter lesion (WML) count/volume and T1 relaxation times. T1 z scores were then obtained between T1 relaxation times in lesion and the corresponding HC tissue. Patient cognitive performance was tested using the Brief Repeatable Battery of Neuro-psychological Tests. Multivariate analysis was applied to assess the contribution of MRI variables (T1 z scores, lesion count/volume) to cognition in patients and Bonferroni correction was applied for multiple comparison. T1 z scores were higher in WML (p memory; (2) T1 z scores in CL-I (β = 0.3; p = 0.03) were independent determinants of long-term memory storage, and (3) lesion volume did not significantly influenced cognitive performances in patients. Our study supports evidence that T1 relaxometry from MP2RAGE provides information about microstructural properties in CL and WML and improves correlation with cognition in RRMS patients, compared to conventional measures of disease burden.

  11. From non-sequential to sequential strong-field multiple ionization: identification of pure and mixed reaction channels

    Energy Technology Data Exchange (ETDEWEB)

    Rudenko, A; Ergler, Th; Zrost, K; Feuerstein, B; Schroeter, C D; Moshammer, R; Ullrich, J [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, D-69117 Heidelberg (Germany); Jesus, V L B de [Centro Federal de Educacao Tecnologica de Quimica de Nilopolis/RJ, Rua Lucio Tavares 1045, Centro-Nilopolis-26530-060, Rio de Janeiro (Brazil)

    2008-04-28

    Momentum distributions of Ne{sup 3-4+} ions created by 795 nm, 25 fs laser pulses have been measured at 10{sup 15}-2 x 10{sup 16} W cm{sup -2} using a 'reaction microscope' in order to characterize the transition regime between non-sequential and sequential strong-field ionizations. We can clearly separate pure and/or mixed recollision-induced (e, ne)-like reactions and sequential (field-induced) processes, and observe transition intensities which agree with recently reported ion-yield data. Our results provide consistent qualitative description of Ne strong-field multiple ionization for all non-relativistic intensities. (fast track communication)

  12. Novel VEGF decoy receptor fusion protein conbercept targeting multiple VEGF isoforms provide remarkable anti-angiogenesis effect in vivo.

    Directory of Open Access Journals (Sweden)

    Qin Wang

    Full Text Available VEGF family factors are known to be the principal stimulators of abnormal angiogenesis, which play a fundamental role in tumor and various ocular diseases. Inhibition of VEGF is widely applied in antiangiogenic therapy. Conbercept is a novel decoy receptor protein constructed by fusing VEGF receptor 1 and VEGF receptor 2 extracellular domains with the Fc region of human immunoglobulin. In this study, we systematically evaluated the binding affinity of conbercept with VEGF isoforms and PlGF by using anti-VEGF antibody (Avastin as reference. BIACORE and ELISA assay results indicated that conbercept could bind different VEGF-A isoforms with higher affinity than reference. Furthermore, conbercept could also bind VEGF-B and PlGF, whereas Avastin showed no binding. Oxygen-induced retinopathy model showed that conbercept could inhibit the formation of neovasularizations. In tumor-bearing nude mice, conbercept could also suppress tumor growth very effectively in vivo. Overall, our study have demonstrated that conbercept could bind with high affinity to multiple VEGF isoforms and consequently provide remarkable anti-angiogenic effect, suggesting the possibility to treat angiogenesis-related diseases such as cancer and wet AMD etc.

  13. Reconfigurable virtual electrowetting channels.

    Science.gov (United States)

    Banerjee, Ananda; Kreit, Eric; Liu, Yuguang; Heikenfeld, Jason; Papautsky, Ian

    2012-02-21

    Lab-on-a-chip systems rely on several microfluidic paradigms. The first uses a fixed layout of continuous microfluidic channels. Such lab-on-a-chip systems are almost always application specific and far from a true "laboratory." The second involves electrowetting droplet movement (digital microfluidics), and allows two-dimensional computer control of fluidic transport and mixing. The merging of the two paradigms in the form of programmable electrowetting channels takes advantage of both the "continuous" functionality of rigid channels based on which a large number of applications have been developed to date and the "programmable" functionality of digital microfluidics that permits electrical control of on-chip functions. In this work, we demonstrate for the first time programmable formation of virtual microfluidic channels and their continuous operation with pressure driven flows using an electrowetting platform. Experimental, theoretical, and numerical analyses of virtual channel formation with biologically relevant electrolyte solutions and electrically-programmable reconfiguration are presented. We demonstrate that the "wall-less" virtual channels can be formed reliably and rapidly, with propagation rates of 3.5-3.8 mm s(-1). Pressure driven transport in these virtual channels at flow rates up to 100 μL min(-1) is achievable without distortion of the channel shape. We further demonstrate that these virtual channels can be switched on-demand between multiple inputs and outputs. Ultimately, we envision a platform that would provide rapid prototyping of microfluidic concepts and would be capable of a vast library of functions and benefitting applications from clinical diagnostics in resource-limited environments to rapid system prototyping to high throughput pharmaceutical applications.

  14. The state of multiple sclerosis: current insight into the patient/health care provider relationship, treatment challenges, and satisfaction.

    Science.gov (United States)

    Tintoré, Mar; Alexander, Maggie; Costello, Kathleen; Duddy, Martin; Jones, David E; Law, Nancy; O'Neill, Gilmore; Uccelli, Antonio; Weissert, Robert; Wray, Sibyl

    2017-01-01

    Managing multiple sclerosis (MS) treatment presents challenges for both patients and health care professionals. Effective communication between patients with MS and their neurologist is important for improving clinical outcomes and quality of life. A closed-ended online market research survey was used to assess the current state of MS care from the perspective of both patients with MS (≥18 years of age) and neurologists who treat MS from Europe and the US and to gain insight into perceptions of treatment expectations/goals, treatment decisions, treatment challenges, communication, and satisfaction with care, based on current clinical practice. A total of 900 neurologists and 982 patients completed the survey, of whom 46% self-identified as having remitting-relapsing MS, 29% secondary progressive MS, and 11% primary progressive MS. Overall, patients felt satisfied with their disease-modifying therapy (DMT); satisfaction related to comfort in speaking with their neurologist and participation in their DMT decision-making process. Patients who self-identified as having relapsing-remitting MS were more likely to be very satisfied with their treatment. Top challenges identified by patients in managing their DMT were cost, side effects/tolerability of treatment, and uncertainty if treatment was working. Half of the patients reported skipping doses, but only 68% told their health care provider that they did so. Several important differences in perception were identified between patients and neurologists concerning treatment selection, satisfaction, expectations, goals, and comfort discussing symptoms, as well as treatment challenges and skipped doses. The study results emphasize that patient/neurologist communication and patient input into the treatment decision-making process likely influence patient satisfaction with treatment.

  15. Which walking capacity tests to use in multiple sclerosis? A multicentre study providing the basis for a core set.

    Science.gov (United States)

    Gijbels, Domien; Dalgas, Ulrik; Romberg, Anders; de Groot, Vincent; Bethoux, Francois; Vaney, Claude; Gebara, Benoit; Medina, Carme Santoyo; Maamâgi, Heigo; Rasova, Kamila; de Noordhout, Benoit Maertens; Knuts, Kathy; Feys, Peter

    2012-03-01

    Many different walking capacity test formats are being used. It is unclear whether walking speed, obtained from short tests, and walking distance, obtained from long tests, provide different clinical information. To determine the differential effect of various short and long walk test formats on gait velocity, and the actual relationship between walking speed and walking distance in multiple sclerosis (MS) patients with diverse ambulation status. A cross-sectional multicentre study design was applied. Ambulatory MS patients (Expanded Disability Status Scale (EDSS) 0-6.5; n = 189) were tested at 11 sites. Short tests consisted of the Timed 25-Foot Walk (static start, fastest speed) and 10-Metre Walk Test (dynamic start, usual and fastest speed). Long tests consisted of the 2- and 6-Minute Walk Tests (fastest speed). Subjects were divided into mild (EDSS 0-4; n = 99) or moderate (EDSS 4.5-6.5; n = 79) disability subgroups. In both subgroups, the start protocol, instructed pace and length of test led to significantly different gait velocities. Fastest walking speed and 6-Minute walking distance showed the strongest correlation (R (2) = 0.78 in mild and R (2) = 0.81 in moderate MS; p tests' relative estimation errors for 6-Minute walking distance were 8-12% in mildly and 15-16% in moderately affected subjects. Based on the 2-Minute Walk Test, estimation errors significantly reduced to approximately 5% in both subgroups. A single short test format at fastest speed accurately describes an MS patient's general walking capacity. For intervention studies, a long test is to be considered. We propose the Timed 25-Foot Walk and 2-Minute Walk Test as standards. Further research on responsiveness is needed.

  16. The state of multiple sclerosis: current insight into the patient/health care provider relationship, treatment challenges, and satisfaction

    Science.gov (United States)

    Tintoré, Mar; Alexander, Maggie; Costello, Kathleen; Duddy, Martin; Jones, David E; Law, Nancy; O’Neill, Gilmore; Uccelli, Antonio; Weissert, Robert; Wray, Sibyl

    2017-01-01

    Background Managing multiple sclerosis (MS) treatment presents challenges for both patients and health care professionals. Effective communication between patients with MS and their neurologist is important for improving clinical outcomes and quality of life. Methods A closed-ended online market research survey was used to assess the current state of MS care from the perspective of both patients with MS (≥18 years of age) and neurologists who treat MS from Europe and the US and to gain insight into perceptions of treatment expectations/goals, treatment decisions, treatment challenges, communication, and satisfaction with care, based on current clinical practice. Results A total of 900 neurologists and 982 patients completed the survey, of whom 46% self-identified as having remitting-relapsing MS, 29% secondary progressive MS, and 11% primary progressive MS. Overall, patients felt satisfied with their disease-modifying therapy (DMT); satisfaction related to comfort in speaking with their neurologist and participation in their DMT decision-making process. Patients who self-identified as having relapsing-remitting MS were more likely to be very satisfied with their treatment. Top challenges identified by patients in managing their DMT were cost, side effects/tolerability of treatment, and uncertainty if treatment was working. Half of the patients reported skipping doses, but only 68% told their health care provider that they did so. Conclusion Several important differences in perception were identified between patients and neurologists concerning treatment selection, satisfaction, expectations, goals, and comfort discussing symptoms, as well as treatment challenges and skipped doses. The study results emphasize that patient/neurologist communication and patient input into the treatment decision-making process likely influence patient satisfaction with treatment. PMID:28053511

  17. TDM/FM/FDMA - A modulation technique for multiple-beam satellites which precludes cochannel interference and allows non-uniform geographic distribution of user channels

    Science.gov (United States)

    Springett, J. C.

    The technique outlined in this paper is intended to eliminate the problems of cochannel interference and uniform geographic distribution of user channels which arise in conventional designs for a multiple spot beam communication satellite to serve mobile telephony users across the CONUS. By time multiplexing FM/FDMA signal ensembles so that only those beams operating on distinct frequency subbands are allowed to transmit concurrently, cochannel interference arising from simultaneous frequency subband reuse is precluded. Thus, time disjoint frequency reuse is accomplished over a repetitive sequence of fixed time slots. By assigning different size subbands to each time slot, a market of nonuniform users can be accommodated. The technique results in a greatly simplified antenna feed system design for the satellite, at a cost of imposing the need for time slot synchronization on the mobile FM receivers whose ability for rejecting adjacent channel interference is somewhat diminished.

  18. TDM/FM/FDMA - A modulation technique for multiple-beam satellites which precludes cochannel interference and allows non-uniform geographic distribution of user channels

    Science.gov (United States)

    Springett, J. C.

    1982-01-01

    The technique outlined in this paper is intended to eliminate the problems of cochannel interference and uniform geographic distribution of user channels which arise in conventional designs for a multiple spot beam communication satellite to serve mobile telephony users across the CONUS. By time multiplexing FM/FDMA signal ensembles so that only those beams operating on distinct frequency subbands are allowed to transmit concurrently, cochannel interference arising from simultaneous frequency subband reuse is precluded. Thus, time disjoint frequency reuse is accomplished over a repetitive sequence of fixed time slots. By assigning different size subbands to each time slot, a market of nonuniform users can be accommodated. The technique results in a greatly simplified antenna feed system design for the satellite, at a cost of imposing the need for time slot synchronization on the mobile FM receivers whose ability for rejecting adjacent channel interference is somewhat diminished.

  19. Experiences with provider and parental attitudes and practices regarding the administration of multiple injections during infant vaccination visits: lessons for vaccine introduction.

    Science.gov (United States)

    Wallace, Aaron S; Mantel, Carsten; Mayers, Gill; Mansoor, Osman; Gindler, Jacqueline S; Hyde, Terri B

    2014-09-15

    An increasing proportion of childhood immunization visits include administration of multiple injections. Future introduction of vaccines to protect against multiple diseases will further increase the number of injections at routine immunization childhood visits, particularly in developing countries that are still scaling up introductions. Parental and healthcare provider attitudes toward multiple injections may affect acceptance of recommended vaccines, and understanding these attitudes may help to inform critical decisions about vaccine introduction. We conducted a systematic review of the literature to examine factors underlying reported parental and healthcare provider concerns and practices related to administration of multiple injections during childhood vaccination visits. Forty-four articles were identified; 42 (95%) were from high income countries, including 27 (61%) from the USA. Providers and parents report concerns about multiple injections, which tend to increase with increasing numbers of injections. Common parental and provider concerns included apprehension about the pain experienced by the child, worry about potential side effects, and uncertainty about vaccine effectiveness. Multiple studies reported that a positive provider recommendation to the parent and a high level of concern about the severity of the target disease were significantly associated with parental acceptance of all injections. Providers often significantly overestimated parental concerns about multiple injections. Providers may play a critical role in the decision for a child to receive all recommended injections. Their overestimation of parental concerns may lead them to postpone recommended vaccinations, which may result in extra visits and delayed vaccination. More research is needed on interventions to overcome provider and parental concern about multiple injections, particularly in developing countries. Published by Elsevier Ltd.

  20. Propagation channel characterization, parameter estimation, and modeling for wireless communications

    CERN Document Server

    Yin, Xuefeng

    2016-01-01

    Thoroughly covering channel characteristics and parameters, this book provides the knowledge needed to design various wireless systems, such as cellular communication systems, RFID and ad hoc wireless communication systems. It gives a detailed introduction to aspects of channels before presenting the novel estimation and modelling techniques which can be used to achieve accurate models. To systematically guide readers through the topic, the book is organised in three distinct parts. The first part covers the fundamentals of the characterization of propagation channels, including the conventional single-input single-output (SISO) propagation channel characterization as well as its extension to multiple-input multiple-output (MIMO) cases. Part two focuses on channel measurements and channel data post-processing. Wideband channel measurements are introduced, including the equipment, technology and advantages and disadvantages of different data acquisition schemes. The channel parameter estimation methods are ...

  1. A cyclic nucleotide-gated channel mutation associated with canine daylight blindness provides insight into a role for the S2 segment tri-Asp motif in channel biogenesis.

    Directory of Open Access Journals (Sweden)

    Naoto Tanaka

    Full Text Available Cone cyclic nucleotide-gated channels are tetramers formed by CNGA3 and CNGB3 subunits; CNGA3 subunits function as homotetrameric channels but CNGB3 exhibits channel function only when co-expressed with CNGA3. An aspartatic acid (Asp to asparagine (Asn missense mutation at position 262 in the canine CNGB3 (D262N subunit results in loss of cone function (daylight blindness, suggesting an important role for this aspartic acid residue in channel biogenesis and/or function. Asp 262 is located in a conserved region of the second transmembrane segment containing three Asp residues designated the Tri-Asp motif. This motif is conserved in all CNG channels. Here we examine mutations in canine CNGA3 homomeric channels using a combination of experimental and computational approaches. Mutations of these conserved Asp residues result in the absence of nucleotide-activated currents in heterologous expression. A fluorescent tag on CNGA3 shows mislocalization of mutant channels. Co-expressing CNGB3 Tri-Asp mutants with wild type CNGA3 results in some functional channels, however, their electrophysiological characterization matches the properties of homomeric CNGA3 channels. This failure to record heteromeric currents suggests that Asp/Asn mutations affect heteromeric subunit assembly. A homology model of S1-S6 of the CNGA3 channel was generated and relaxed in a membrane using molecular dynamics simulations. The model predicts that the Tri-Asp motif is involved in non-specific salt bridge pairings with positive residues of S3/S4. We propose that the D262N mutation in dogs with CNGB3-day blindness results in the loss of these inter-helical interactions altering the electrostatic equilibrium within in the S1-S4 bundle. Because residues analogous to Tri-Asp in the voltage-gated Shaker potassium channel family were implicated in monomer folding, we hypothesize that destabilizing these electrostatic interactions impairs the monomer folding state in D262N mutant CNG

  2. Cardiac sodium channel NaV1.5 distribution in myocytes via interacting proteins: the multiple pool model.

    Science.gov (United States)

    Shy, Diana; Gillet, Ludovic; Abriel, Hugues

    2013-04-01

    The cardiac sodium current (INa) is responsible for the rapid depolarization of cardiac cells, thus allowing for their contraction. It is also involved in regulating the duration of the cardiac action potential (AP) and propagation of the impulse throughout the myocardium. Cardiac INa is generated by the voltage-gated Na(+) channel, NaV1.5, a 2016-residue protein which forms the pore of the channel. Over the past years, hundreds of mutations in SCN5A, the human gene coding for NaV1.5, have been linked to many cardiac electrical disorders, including the congenital and acquired long QT syndrome, Brugada syndrome, conduction slowing, sick sinus syndrome, atrial fibrillation, and dilated cardiomyopathy. Similar to many membrane proteins, NaV1.5 has been found to be regulated by several interacting proteins. In some cases, these different proteins, which reside in distinct membrane compartments (i.e. lateral membrane vs. intercalated disks), have been shown to interact with the same regulatory domain of NaV1.5, thus suggesting that several pools of NaV1.5 channels may co-exist in cardiac cells. The aim of this review article is to summarize the recent works that demonstrate its interaction with regulatory proteins and illustrate the model that the sodium channel NaV1.5 resides in distinct and different pools in cardiac cells. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Cardiac Pathways of Differentiation, Metabolism and Contraction. Copyright © 2012 Elsevier B.V. All rights reserved.

  3. Access-Control Schemes for Real-Time and Store-and-Forward Multiple-Access Communication Channels

    Science.gov (United States)

    1980-01-01

    Demand-Assignment TDHA Schemes If the message traffic arriving at the sources is steady, then we can employ a Fixed-Assignment TDMA scheme by dedicating...messages are assumed to be independent and identically 19 1b-- distributed with mean U-1 (seconds). 2.3 The Performance of Demand-Assignment TDHA ...a Type j request, j = 1, 2, is Nj L j =P (K J) ( K ) . (3.8) 3.4 Optimal Allocation of Slots Under a Demand-Assignment TDHA scheme, the channel frame

  4. Hospital readmission after multiple major operative procedures among patients with employer provided health insurance.

    Science.gov (United States)

    Kim, Yuhree; Gani, Faiz; Canner, Joseph K; Margonis, Georgios A; Makary, Martin A; Schneider, Eric B; Pawlik, Timothy M

    2016-07-01

    Most studies report data only on readmission within 30 days of discharge from the same hospital following a single procedure. We sought to define the incidence of early versus late hospital readmission among patients undergoing multiple major operative procedures. Patients were identified using the MarketScan database from 2010-2012. Multivariable logistic regression analysis was performed to identify factors associated with early (≤30 days) versus late readmission (31-90 days) among patients who underwent multiple operative procedures. A total of 194,111 patients were identified of whom 63.2% (n = 122,660) underwent an abdominal procedure (esophagectomy, pancreatectomy, hepatectomy, colectomy, lung resection, and gastrectomy), while the remaining 71,451 (36.8%) patients underwent a cardiovascular procedure (repair of abdominal aortic aneurysm, coronary-artery bypass grafting, carotid endarterectomy, and mitral/aortic valve replacement). A total of 3,444 patients underwent >1 simultaneous procedure (abdominal: 885, 0.7%; cardiovascular: 2,559, 3.6%). The overall incidence of 90-day readmission was 15.6% (n = 30,309); 9.6% of patients were readmitted early, while 6.0% of patients were readmitted late. Readmission was higher among patients undergoing multiple procedures (21.8% vs 15.5%; P 15% of patients being readmitted within 90 days of index discharge. Compared with patients undergoing a single operative procedure, patients undergoing multiple operative procedures demonstrated an increased risk for readmission within 90 days of discharge and were more likely to be readmitted within 30 days of index discharge. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Dislocation Reduction and Stress Relaxation of GaN and InGaN Multiple Quantum Wells with Improved Performance via Serpentine Channel Patterned Mask.

    Science.gov (United States)

    Ji, Qingbin; Li, Lei; Zhang, Wei; Wang, Jia; Liu, Peichi; Xie, Yahong; Yan, Tongxing; Yang, Wei; Chen, Weihua; Hu, Xiaodong

    2016-08-24

    The existence of high threading dislocation density (TDD) in GaN-based epilayers is a long unsolved problem, which hinders further applications of defect-sensitive GaN-based devices. Multiple-modulation of epitaxial lateral overgrowth (ELOG) is used to achieve high-quality GaN template on a novel serpentine channel patterned sapphire substrate (SCPSS). The dislocation blocking brought by the serpentine channel patterned mask, coupled with repeated dislocation bending, can reduce the dislocation density to a yet-to-be-optimized level of ∼2 × 10(5) to 2 × 10(6) cm(-2). About 80% area utilization rate of GaN with low TDD and stress relaxation is obtained. The periodical variations of dislocation density, optical properties and residual stress in GaN-based epilayers on SCPSS are analyzed. The quantum efficiency of InGaN/GaN multiple quantum wells (MQWs) on it can be increased by 52% compared with the conventional sapphire substrate. The reduced nonradiative recombination centers, the enhanced carrier localization, and the suppressed quantum confined Stark effect, are the main determinants of improved luminous performance in MQWs on SCPSS. This developed ELOG on serpentine shaped mask needs no interruption and regrowth, which can be a promising candidate for the heteroepitaxy of semipolar/nonpolar GaN and GaAs with high quality.

  6. Secret-key agreement over spatially correlated multiple-antenna channels in the low-SNR regime

    KAUST Repository

    Zorgui, Marwen

    2015-09-28

    We consider secret-key agreement with public discussion over Rayleigh fast-fading channels with transmit, receive and eavesdropper correlation. The legitimate receiver along with the eavesdropper are assumed to have perfect channel knowledge while the transmitter has only knowledge of the correlation matrices. We analyze the secret-key capacity in the low signal-to-noise ratio (SNR) regime. We derive closed-form expressions for the first and the second derivatives of the secret-key capacity with respect to SNR at SNR= 0, for arbitrary correlation matrices and number of transmit, receive and eavesdropper antennas. Moreover, we identify optimal transmission strategies achieving these derivatives. For instance, we prove that achieving the first and the second derivatives requires a uniform power distribution between the eigenvectors spanning the maximal-eigenvalue eigenspace of the transmit correlation matrix. We also compare the optimal transmission scheme to a simple uniform power allocation. Finally, we express the minimum energy required for sharing a secret-key bit as well as the wideband slope in terms of the system parameters.

  7. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception.

    Science.gov (United States)

    Bang, S; Yoo, S; Yang, T J; Cho, H; Kim, Y G; Hwang, S W

    2010-10-01

    Temperature-sensitive transient receptor potential ion channels (thermoTRPs) expressed in primary sensory neurons and skin keratinocytes play a crucial role as peripheral pain detectors. Many natural and synthetic ligands have been found to act on thermoTRPs, but little is known about endogenous compounds that inhibit these TRPs. Here, we asked whether resolvin D1 (RvD1), a naturally occurring anti-inflammatory and pro-resolving lipid molecule is able to affect the TRP channel activation. We examined the effect of RvD1 on the six thermoTRPs using Ca(2+) imaging and whole cell electrophysiology experiments using the HEK cell heterologous expression system, cultured sensory neurons and HaCaT keratinocytes. We also checked changes in agonist-specific acute licking/flicking or flinching behaviours and TRP-related mechanical and thermal pain behaviours using Hargreaves, Randall-Selitto and von Frey assay systems with or without inflammation. RvD1 inhibited the activities of TRPA1, TRPV3 and TRPV4 at nanomolar and micromolar levels. Consistent attenuations in agonist-specific acute pain behaviours by immediate peripheral administration with RvD1 were also observed. Furthermore, local pretreatment with RvD1 significantly reversed mechanical and thermal hypersensitivity in inflamed tissues. RvD1 was a novel endogenous inhibitor for several sensory TRPs. The results of our behavioural studies suggest that RvD1 has an analgesic potential via these TRP-related mechanisms.

  8. Quantitative analysis of oyster larval proteome provides new insights into the effects of multiple climate change stressors

    KAUST Repository

    Dineshram, Ramadoss

    2016-03-19

    The metamorphosis of planktonic larvae of the Pacific oyster (Crassostrea gigas) underpins their complex life-history strategy by switching on the molecular machinery required for sessile life and building calcite shells. Metamorphosis becomes a survival bottleneck, which will be pressured by different anthropogenically induced climate change-related variables. Therefore, it is important to understand how metamorphosing larvae interact with emerging climate change stressors. To predict how larvae might be affected in a future ocean, we examined changes in the proteome of metamorphosing larvae under multiple stressors: decreased pH (pH 7.4), increased temperature (30 °C), and reduced salinity (15 psu). Quantitative protein expression profiling using iTRAQ-LC-MS/MS identified more than 1300 proteins. Decreased pH had a negative effect on metamorphosis by down-regulating several proteins involved in energy production, metabolism, and protein synthesis. However, warming switched on these down-regulated pathways at pH 7.4. Under multiple stressors, cell signaling, energy production, growth, and developmental pathways were up-regulated, although metamorphosis was still reduced. Despite the lack of lethal effects, significant physiological responses to both individual and interacting climate change related stressors were observed at proteome level. The metamorphosing larvae of the C. gigas population in the Yellow Sea appear to have adequate phenotypic plasticity at the proteome level to survive in future coastal oceans, but with developmental and physiological costs. © 2016 John Wiley & Sons Ltd.

  9. [A homeless, uninsured illegal alien suffering from psychosis and multiple fractures: providing efficient care to such patients].

    Science.gov (United States)

    van Mill, Josine G; van Laere, Igor R A L; Deunk, Jaap; Nauta, Klaas-Jan

    2015-01-01

    We present the case of a 37-year-old psychotic, homeless man from Albania, who sustained multiple fractures after jumping from a third-floor window. The patient was uninsured and did not consent to transfer to a hospital in Albania because of paranoid delusions. Eventually he was hospitalised for nearly 30 weeks in hospital and a nursing home. Various factors of this complex case are considered, such as the co-morbidity of somatic and psychiatric symptoms, the absence of family support and the financial regulations that apply to uninsured patients. Doctors who are presented with similar complex cases are advised to organise frequent multidisciplinary evaluations with all health care workers involved. We encourage searching for creative interventions which serve both the best interests of the individual patient, and - where possible - also minimize the total cost of health care to society.

  10. Defining treatment success in rosacea as 'clear' may provide multiple patient benefits: results of a pooled analysis.

    Science.gov (United States)

    Webster, Guy; Schaller, Martin; Tan, Jerry; Jackson, J Mark; Kerrouche, Nabil; Schäfer, Gregor

    2017-08-01

    Rosacea treatment success is usually defined as a score of 1 ('almost clear') or 0 ('clear') on the 5-point Investigator Global Assessment (IGA) scale. To evaluate whether, after successful treatment, 'clear' subjects had better outcomes than 'almost clear' subjects. A pooled analysis was performed on 1366 rosacea subjects from four randomized controlled trials with IGA before and after treatment (ivermectin, metronidazole or vehicle). Assessments included the Dermatology Life Quality Index (DLQI) questionnaire and subject assessment of rosacea improvement. In one trial, patients were followed after the treatment period to measure time to relapse (IGA score ≥2). At end of treatment, more 'clear' than 'almost clear' subjects had a clinically meaningful difference in DLQI (59% vs. 44%; p rosacea (77% vs. 42%; p < .001). The median time to relapse was more than 8 months for 'clear' vs. 3 months for 'almost clear' subjects (p < .0001). Achieving an endpoint of 'clear' (IGA 0) vs. 'almost clear' (IGA 1) is associated with multiple positive patient outcomes, including delayed time to relapse.

  11. Islet Transplantation Provides Superior Glycemic Control With Less Hypoglycemia Compared With Continuous Subcutaneous Insulin Infusion or Multiple Daily Insulin Injections.

    Science.gov (United States)

    Holmes-Walker, Deborah Jane; Gunton, Jenny E; Hawthorne, Wayne; Payk, Marlene; Anderson, Patricia; Donath, Susan; Loudovaris, Tom; Ward, Glenn M; Kay, Thomas Wh; OʼConnell, Philip J

    2017-06-01

    The aim was to compare efficacy of multiple daily injections (MDI), continuous subcutaneous insulin infusion (CSII) and islet transplantation to reduce hypoglycemia and glycemic variability in type 1 diabetes subjects with severe hypoglycemia. This was a within-subject, paired comparison of MDI and CSII and CSII with 12 months postislet transplantation in 10 type 1 diabetes subjects referred with severe hypoglycemia, suitable for islet transplantation. Individuals were assessed with HbA1c, Edmonton Hypoglycemia Score (HYPOscore), continuous glucose monitoring (CGM) and in 8 subjects measurements of glucose variability using standard deviation of glucose (SD glucose) from CGM and continuous overlapping net glycemic action using a 4 hour interval (CONGA4). After changing from MDI to CSII before transplantation, 10 subjects reduced median HYPOscore from 2028 to 1085 (P transplantation, there were significant reductions in all baseline parameters versus CSII, respectively, HbA1c (6.4% cf 8.2%), median HYPOscore (0 cf 1085), mean glucose (7.1 cf 8.6 mmol L), SD glucose (1.7 cf 3.2 mmol/L), and CONGA4 (1.6 cf 3.0). In subjects with severe hypoglycemia suitable for islet transplantation, CSII decreased hypoglycemia frequency and glycemic variability compared with MDI whereas islet transplantation resolved hypoglycemia and further improved glycemic variability regardless of insulin independence.

  12. Seasonal patterns in δ(2) H values of multiple tissues from Andean birds provide insights into elevational migration.

    Science.gov (United States)

    Villegas, Mariana; Newsome, Seth D; Blake, John G

    2016-12-01

    Elevational migration is a widespread phenomenon in tropical avifauna but it is difficult to identify using traditional approaches. Hydrogen isotope (δ(2) H) values of precipitation decrease with elevation so δ(2) H analysis of multiple bird tissues with different isotopic incorporation rates may be a reliable method for characterizing seasonal elevational migration. Here we compare δ(2) H values in metabolically inert (feathers and claws) and metabolically active (whole blood) tissues to examine whether an upslope migration occurs prior to the breeding season in the Yungas Manakin (Chiroxiphia boliviana). We compare results from C. boliviana with data from a known elevational migrant, the Streak-necked Flycatcher (Mionectes striaticollis). Opposite to our expectations, tissue δ(2) H values increased over time, largely reflecting seasonal patterns in precipitation δ(2) H rather than elevational effects; linear mixed-effects models with strongest support included ordinal date, tissue type, and elevation. This seasonal increase in precipitation δ(2) H is a general phenomenon in both tropical and temperate mountain ranges. We use these data to propose a hypothetical framework that predicts different patterns in tissue δ(2) H values collected in different seasons from residents and elevational migrants. This framework can serve as a reference for future studies that assess elevational migration in birds and other animals. © 2016 by the Ecological Society of America.

  13. Which walking capacity tests to use in multiple sclerosis? A multicentre study providing the basis for a core set

    NARCIS (Netherlands)

    Gijbels, D.; Dalgas, U.; Romberg, A.; de Groot, V.; Bethoux, F.; Vaney, C.; Gebara, B.; Santoyo, C.; Maamagi, H.; Rasova, K.; de Maertens, N.B.; Knuts, K.; Feys, P.

    2012-01-01

    Background: Many different walking capacity test formats are being used. It is unclear whether walking speed, obtained from short tests, and walking distance, obtained from long tests, provide different clinical information. Objectives: To determine the differential effect of various short and long

  14. A simple preparative free-flow electrophoresis joined with gratis gravity: I. Gas cushion injector and self-balance collector instead of multiple channel pump.

    Science.gov (United States)

    Chen, Su; Palmer, James F; Zhang, Wei; Shao, Jing; Li, Si; Fan, Liu-Yin; Sun, Ren; Dong, Yu-Chao; Cao, Cheng-Xi

    2009-06-01

    This paper describes a novel free-flow electrophoresis (FFE), which is joined with gratis gravity, gas cushion injector (GCI) and self-balance collector instead of multiple channel pump, for the purpose of preparative purification. The FFE was evaluated by systemic experiments. The results manifest that (i) even though one-channel peristaltic pump is used for the driving of background buffer, there is still stable flow in the FFE chamber; (ii) the stable flow is induced by the gravity-induced pressure due to the difference of buffer surfaces in the GCI and self-balance collector; (iii) the pulse flow of background buffer induced by the peristaltic pump is greatly reduced by the GCI with good compressibility of included air; (iv) the FFE can be well used for zone electrophoretic separation of amino acids; (v) up to 20 inlets simultaneous sample injection and up to five to tenfold condensation of amino acid can be achieved by combining the FFE device with the method of moving reaction boundary. To the best of authors' knowledge, FFE has not been used for such separation and condensation of amino acids. The relevant results achieved in the paper have evident significance for the development of preparative FFE.

  15. Mosasauroid phylogeny under multiple phylogenetic methods provides new insights on the evolution of aquatic adaptations in the group.

    Directory of Open Access Journals (Sweden)

    Tiago R Simões

    Full Text Available Mosasauroids were a successful lineage of squamate reptiles (lizards and snakes that radiated during the Late Cretaceous (95-66 million years ago. They can be considered one of the few lineages in the evolutionary history of tetrapods to have acquired a fully aquatic lifestyle, similarly to whales, ichthyosaurs and plesiosaurs. Despite a long history of research on this group, their phylogenetic relationships have only been tested so far using traditional (unweighted maximum parsimony. However, hypotheses of mosasauroid relationships and the recently proposed multiple origins of aquatically adapted pelvic and pedal features in this group can be more thoroughly tested by methods that take into account variation in branch lengths and evolutionary rates. In this study, we present the first mosasauroid phylogenetic analysis performed under different analytical methods, including maximum likelihood, Bayesian inference, and implied weighting maximum parsimony. The results indicate a lack of congruence in the topological position of halisaurines and Dallasaurus. Additionally, the genus Prognathodon is paraphyletic under all hypotheses. Interestingly, a number of traditional mosasauroid clades become weakly supported, or unresolved, under Bayesian analyses. The reduced resolutions in some consensus trees create ambiguities concerning the evolution of fully aquatic pelvic/pedal conditions under many analyses. However, when enough resolution was obtained, reversals of the pelvic/pedal conditions were favoured by parsimony and likelihood ancestral state reconstructions instead of independent origins of aquatic features in mosasauroids. It is concluded that most of the observed discrepancies among the results can be associated with different analytical procedures, but also due to limited postcranial data on halisaurines, yaguarasaurines and Dallasaurus.

  16. Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

    DEFF Research Database (Denmark)

    Willems, Sara M; Wright, Daniel J.; Day, Felix R

    2017-01-01

    Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195...... with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk. In conclusion, our findings provide new biological insight into the mechanistic underpinnings of grip...

  17. Detection of Multiple Innervation Zones from Multi-Channel Surface EMG Recordings with Low Signal-to-Noise Ratio Using Graph-Cut Segmentation.

    Directory of Open Access Journals (Sweden)

    Hamid Reza Marateb

    Full Text Available Knowledge of the location of muscle Innervation Zones (IZs is important in many applications, e.g. for minimizing the quantity of injected botulinum toxin for the treatment of spasticity or for deciding on the type of episiotomy during child delivery. Surface EMG (sEMG can be noninvasively recorded to assess physiological and morphological characteristics of contracting muscles. However, it is not often possible to record signals of high quality. Moreover, muscles could have multiple IZs, which should all be identified. We designed a fully-automatic algorithm based on the enhanced image Graph-Cut segmentation and morphological image processing methods to identify up to five IZs in 60-ms intervals of very-low to moderate quality sEMG signal detected with multi-channel electrodes (20 bipolar channels with Inter Electrode Distance (IED of 5 mm. An anisotropic multilayered cylinder model was used to simulate 750 sEMG signals with signal-to-noise ratio ranging from -5 to 15 dB (using Gaussian noise and in each 60-ms signal frame, 1 to 5 IZs were included. The micro- and macro- averaged performance indices were then reported for the proposed IZ detection algorithm. In the micro-averaging procedure, the number of True Positives, False Positives and False Negatives in each frame were summed up to generate cumulative measures. In the macro-averaging, on the other hand, precision and recall were calculated for each frame and their averages are used to determine F1-score. Overall, the micro (macro-averaged sensitivity, precision and F1-score of the algorithm for IZ channel identification were 82.7% (87.5%, 92.9% (94.0% and 87.5% (90.6%, respectively. For the correctly identified IZ locations, the average bias error was of 0.02±0.10 IED ratio. Also, the average absolute conduction velocity estimation error was 0.41±0.40 m/s for such frames. The sensitivity analysis including increasing IED and reducing interpolation coefficient for time samples was

  18. Photonic Crystal Waveguide Weakly Interacting with Multiple Off-Channel Resonant Features Formed of Kerr Nonlinear Dielectric Media

    Directory of Open Access Journals (Sweden)

    A. R. McGurn

    2007-01-01

    a number of analytical results are presented providing simple explanations of the quantitative behaviors of the systems. A relationship of these systems to forms of electromagnetic-induced transparency and modifications of waveguide dispersion relations is discussed.

  19. Downlink Channel Estimation in Cellular Systems with Antenna Arrays at Base Stations Using Channel Probing with Feedback

    Directory of Open Access Journals (Sweden)

    Biguesh Mehrzad

    2004-01-01

    Full Text Available In mobile communication systems with multisensor antennas at base stations, downlink channel estimation plays a key role because accurate channel estimates are needed for transmit beamforming. One efficient approach to this problem is channel probing with feedback. In this method, the base station array transmits probing (training signals. The channel is then estimated from feedback reports provided by the users. This paper studies the performance of the channel probing method with feedback using a multisensor base station antenna array and single-sensor users. The least squares (LS, linear minimum mean square error (LMMSE, and a new scaled LS (SLS approaches to the channel estimation are studied. Optimal choice of probing signals is investigated for each of these techniques and their channel estimation performances are analyzed. In the case of multiple LS channel estimates, the best linear unbiased estimation (BLUE scheme for their linear combining is developed and studied.

  20. Transient Receptor Potential Channels in the Vasculature

    Science.gov (United States)

    Earley, Scott; Brayden, Joseph E.

    2015-01-01

    The mammalian genome encodes 28 distinct members of the transient receptor potential (TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for different ionic species. Multiple TRP channels are present in all cells and are involved in diverse aspects of cellular function, including sensory perception and signal transduction. Notably, TRP channels are involved in regulating vascular function and pathophysiology, the focus of this review. TRP channels in vascular smooth muscle cells participate in regulating contractility and proliferation, whereas endothelial TRP channel activity is an important contributor to endothelium-dependent vasodilation, vascular wall permeability, and angiogenesis. TRP channels are also present in perivascular sensory neurons and astrocytic endfeet proximal to cerebral arterioles, where they participate in the regulation of vascular tone. Almost all of these functions are mediated by changes in global intracellular Ca2+ levels or subcellular Ca2+ signaling events. In addition to directly mediating Ca2+ entry, TRP channels influence intracellular Ca2+ dynamics through membrane depolarization associated with the influx of cations or through receptor- or store-operated mechanisms. Dysregulation of TRP channels is associated with vascular-related pathologies, including hypertension, neointimal injury, ischemia-reperfusion injury, pulmonary edema, and neurogenic inflammation. In this review, we briefly consider general aspects of TRP channel biology and provide an in-depth discussion of the functions of TRP channels in vascular smooth muscle cells, endothelial cells, and perivascular cells under normal and pathophysiological conditions. PMID:25834234

  1. cGMP-Elevating Compounds and Ischemic Conditioning Provide Cardioprotection Against Ischemia and Reperfusion Injury via Cardiomyocyte-Specific BK Channels.

    Science.gov (United States)

    Frankenreiter, Sandra; Bednarczyk, Piotr; Kniess, Angelina; Bork, Nadja I; Straubinger, Julia; Koprowski, Piotr; Wrzosek, Antoni; Mohr, Eva; Logan, Angela; Murphy, Michael P; Gawaz, Meinrad; Krieg, Thomas; Szewczyk, Adam; Nikolaev, Viacheslav O; Ruth, Peter; Lukowski, Robert

    2017-12-12

    The nitric oxide-sensitive guanylyl cyclase/cGMP-dependent protein kinase type I signaling pathway can afford protection against the ischemia/reperfusion injury that occurs during myocardial infarction. Reportedly, voltage and Ca2+-activated K+ channels of the BK type are stimulated by cGMP/cGMP-dependent protein kinase type I, and recent ex vivo studies implicated that increased BK activity favors the survival of the myocardium at ischemia/reperfusion. It remains unclear, however, whether the molecular events downstream of cGMP involve BK channels present in cardiomyocytes or in other cardiac cell types. Gene-targeted mice with a cardiomyocyte- or smooth muscle cell-specific deletion of the BK (CMBK or SMBK knockouts) were subjected to the open-chest model of myocardial infarction. Infarct sizes of the conditional mutants were compared with litter-matched controls, global BK knockout, and wild-type mice. Cardiac damage was assessed after mechanical conditioning or pharmacological stimulation of the cGMP pathway and by using direct modulators of BK. Long-term outcome was studied with respect to heart functions and cardiac fibrosis in a chronic myocardial infarction model. Global BK knockouts and CMBK knockouts, in contrast with SMBK knockouts, exhibited significantly larger infarct sizes compared with their respective controls. Ablation of CMBK resulted in higher serum levels of cardiac troponin I and elevated amounts of reactive oxygen species, lower phosphorylated extracellular receptor kinase and phosphorylated AKT levels and an increase in myocardial apoptosis. Moreover, CMBK was required to allow beneficial effects of both nitric oxide-sensitive guanylyl cyclase activation and inhibition of the cGMP-degrading phosphodiesterase-5, ischemic preconditioning, and postconditioning regimens. To this end, after 4 weeks of reperfusion, fibrotic tissue increased and myocardial strain echocardiography was significantly compromised in CMBK-deficient mice. Lack of CMBK

  2. Temperature-Sensitive Cav1.2 Calcium Channels Support Intrinsic Firing of Pyramidal Neurons and Provide a Target for the Treatment of Febrile Seizures

    Science.gov (United States)

    Radzicki, Daniel; Yau, Hau-Jie; Pollema-Mays, Sarah L.; Mlsna, Lauren; Cho, Kangho; Koh, Sookyong

    2013-01-01

    Febrile seizures are associated with increased brain temperature and are often resistant to treatments with antiepileptic drugs, such as carbamazepine and phenytoin, which are sodium channel blockers. Although they are clearly correlated with the hyperthermic condition, the precise cellular mechanisms of febrile seizures remain unclear. We performed patch-clamp recordings from pyramidal cells in acute rat brain slices at temperatures up to 40°C and found that, at ≥37°C, L-type calcium channels are active at unexpectedly hyperpolarized potentials and drive intrinsic firing, which is also supported by a temperature-dependent, gadolinium-sensitive sodium conductance. Pharmacological data, RT-PCR, and the current persistence in Cav1.3 knock-out mice suggested a critical contribution of Cav1.2 subunits to the temperature-dependent intrinsic firing, which was blocked by nimodipine. Because intrinsic firing may play a critical role in febrile seizures, we tested the effect of nimodipine in an in vivo model of febrile seizures and found that this drug dramatically reduces both the incidence and duration of febrile seizures in rat pups, suggesting new possibilities of intervention for this important pathological condition. PMID:23761887

  3. Patient-provider relationship as mediator between adult attachment and self-management in primary care patients with multiple chronic conditions.

    Science.gov (United States)

    Brenk-Franz, Katja; Strauß, Bernhard; Tiesler, Fabian; Fleischhauer, Christian; Schneider, Nico; Gensichen, Jochen

    2017-06-01

    The conceptual model of attachment theory has been applied to understand the predispositions of patients in medical care and the patient-provider relationship. In patients with chronic conditions insecure attachment was connected to poorer self-management. The patient-provider relationship is associated with a range of health related outcomes and self-management skills. We determined whether the quality of the patient-provider relationship mediates the link between adult attachment and self-management among primary care patients with multiple chronic diseases. 209 patients with a minimum of three chronic diseases (including type II diabetes, hypertension and at least one other chronic condition) between the ages of 50 and 85 from eight general practices were included in the APRICARE cohort study. Adult attachment was measured via self-report (ECR-RD), self-management skills by the FERUS and the patient-provider relationship by the PRA-D. The health status and chronicity were assessed by the GP. Multiple mediation analyses were used to examine whether aspects of the patient-provider relationship (communication, information, affectivity) are a mediators of associations between adult attachment and self-management. The analysis revealed that the quality of the patient-provider relationship mediated the effect of attachment on self-management in patients with multiple chronic conditions. Particularly the quality of communication and information over the course of treatment has a significant mediating influence. A personalized, attachment-related approach that promotes active patient-provider communication and gives information about the treatment to the patient may improve self-management skills in patients. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Drosophila TRP channels and animal behavior

    Science.gov (United States)

    Fowler, Melissa A.; Montell, Craig

    2012-01-01

    Multiple classes of cell surface receptors and ion channels participate in the detection of changes in environmental stimuli, and thereby influence animal behavior. Among the many classes of ion channels, Transient Receptor Potential (TRP) cation channels are notable in contributing to virtually every sensory modality, and in controlling a daunting array of behaviors. TRP channels appear to be conserved in all metazoan organisms including worms, insects and humans. Flies encode 13 TRPs, most of which are expressed and function in sensory neurons, and impact behaviors ranging from phototaxis to thermotaxis, gravitaxis, the avoidance of noxious tastants and smells and proprioception. Multiple diseases result from defects in TRPs, and flies provide an excellent animal model for dissecting the mechanisms underlying “TRPopathies.” Drosophila TRPs also function in the sensation of botanically derived insect repellents, and related TRPs in insect pests are potential targets for the development of improved repellents to combat insect-borne diseases. PMID:22877650

  5. Identification and analysis of genome-wide SNPs provide insight into signatures of selection and domestication in channel catfish (Ictalurus punctatus.

    Directory of Open Access Journals (Sweden)

    Luyang Sun

    Full Text Available Domestication and selection for important performance traits can impact the genome, which is most often reflected by reduced heterozygosity in and surrounding genes related to traits affected by selection. In this study, analysis of the genomic impact caused by domestication and artificial selection was conducted by investigating the signatures of selection using single nucleotide polymorphisms (SNPs in channel catfish (Ictalurus punctatus. A total of 8.4 million candidate SNPs were identified by using next generation sequencing. On average, the channel catfish genome harbors one SNP per 116 bp. Approximately 6.6 million, 5.3 million, 4.9 million, 7.1 million and 6.7 million SNPs were detected in the Marion, Thompson, USDA103, Hatchery strain, and wild population, respectively. The allele frequencies of 407,861 SNPs differed significantly between the domestic and wild populations. With these SNPs, 23 genomic regions with putative selective sweeps were identified that included 11 genes. Although the function for the majority of the genes remain unknown in catfish, several genes with known function related to aquaculture performance traits were included in the regions with selective sweeps. These included hypoxia-inducible factor 1β. HIFιβ.. and the transporter gene ATP-binding cassette sub-family B member 5 (ABCB5. HIF1β. is important for response to hypoxia and tolerance to low oxygen levels is a critical aquaculture trait. The large numbers of SNPs identified from this study are valuable for the development of high-density SNP arrays for genetic and genomic studies of performance traits in catfish.

  6. Visualizing multi-channel networks

    DEFF Research Database (Denmark)

    Antemijczuk, Paweł; Magiera, Marta; Jørgensen, Sune Lehmann

    2014-01-01

    In this paper, we propose a visualization to illustrate social interactions, built from multiple distinct channels of communication. The visualization displays a summary of dense personal information in a compact graphical notation. The starting point is an abstract drawing of a spider’s web. Below......, we describe the meaning of each data dimension along with the background and motivation for their inclusion. Finally, we present feedback provided by the users (31 individuals) of the visualization....

  7. The invisible work of personal health information management among people with multiple chronic conditions: qualitative interview study among patients and providers.

    Science.gov (United States)

    Ancker, Jessica S; Witteman, Holly O; Hafeez, Baria; Provencher, Thierry; Van de Graaf, Mary; Wei, Esther

    2015-06-04

    A critical problem for patients with chronic conditions who see multiple health care providers is incomplete or inaccurate information, which can contribute to lack of care coordination, low quality of care, and medical errors. As part of a larger project on applications of consumer health information technology (HIT) and barriers to its use, we conducted a semistructured interview study with patients with multiple chronic conditions (MCC) with the objective of exploring their role in managing their personal health information. Semistructured interviews were conducted with patients and providers. Patients were eligible if they had multiple chronic conditions and were in regular care with one of two medical organizations in New York City; health care providers were eligible if they had experience caring for patients with multiple chronic conditions. Analysis was conducted from a grounded theory perspective, and recruitment was concluded when saturation was achieved. A total of 22 patients and 7 providers were interviewed; patients had an average of 3.5 (SD 1.5) chronic conditions and reported having regular relationships with an average of 5 providers. Four major themes arose: (1) Responsibility for managing medical information: some patients perceived information management and sharing as the responsibility of health care providers; others—particularly those who had had bad experiences in the past—took primary responsibility for information sharing; (2) What information should be shared: although privacy concerns did influence some patients' perceptions of sharing of medical data, decisions about what to share were also heavily influenced by their understanding of health and disease and by the degree to which they understood the health care system; (3) Methods and tools varied: those patients who did take an active role in managing their records used a variety of electronic tools, paper tools, and memory; and (4) Information management as invisible work

  8. A Knowledge-Modeling Approach to Integrate Multiple Clinical Practice Guidelines to Provide Evidence-Based Clinical Decision Support for Managing Comorbid Conditions.

    Science.gov (United States)

    Abidi, Samina

    2017-10-26

    Clinical management of comorbidities is a challenge, especially in a clinical decision support setting, as it requires the safe and efficient reconciliation of multiple disease-specific clinical procedures to formulate a comorbid therapeutic plan that is both effective and safe for the patient. In this paper we pursue the integration of multiple disease-specific Clinical Practice Guidelines (CPG) in order to manage co-morbidities within a computerized Clinical Decision Support System (CDSS). We present a CPG integration framework-termed as COMET (Comorbidity Ontological Modeling & ExecuTion) that manifests a knowledge management approach to model, computerize and integrate multiple CPG to yield a comorbid CPG knowledge model that upon execution can provide evidence-based recommendations for handling comorbid patients. COMET exploits semantic web technologies to achieve (a) CPG knowledge synthesis to translate a paper-based CPG to disease-specific clinical pathways (CP) that include specialized co-morbidity management procedures based on input from domain experts; (b) CPG knowledge modeling to computerize the disease-specific CP using a Comorbidity CPG ontology; (c) CPG knowledge integration by aligning multiple ontologically-modeled CP to develop a unified comorbid CPG knowledge model; and (e) CPG knowledge execution using reasoning engines to derive CPG-mediated recommendations for managing patients with comorbidities. We present a web-accessible COMET CDSS that provides family physicians with CPG-mediated comorbidity decision support to manage Atrial Fibrillation and Chronic Heart Failure. We present our qualitative and quantitative analysis of the knowledge content and usability of COMET CDSS.

  9. Secret Sharing over Fast-Fading MIMO Wiretap Channels

    Directory of Open Access Journals (Sweden)

    Bloch Matthieu

    2009-01-01

    Full Text Available Secret sharing over the fast-fading MIMO wiretap channel is considered. A source and a destination try to share secret information over a fast-fading MIMO channel in the presence of an eavesdropper who also makes channel observations that are different from but correlated to those made by the destination. An interactive, authenticated public channel with unlimited capacity is available to the source and destination for the secret sharing process. This situation is a special case of the "channel model with wiretapper" considered by Ahlswede and Csiszár. An extension of their result to continuous channel alphabets is employed to evaluate the key capacity of the fast-fading MIMO wiretap channel. The effects of spatial dimensionality provided by the use of multiple antennas at the source, destination, and eavesdropper are then investigated.

  10. Secret Sharing over Fast-Fading MIMO Wiretap Channels

    Directory of Open Access Journals (Sweden)

    Tan F. Wong

    2009-01-01

    Full Text Available Secret sharing over the fast-fading MIMO wiretap channel is considered. A source and a destination try to share secret information over a fast-fading MIMO channel in the presence of an eavesdropper who also makes channel observations that are different from but correlated to those made by the destination. An interactive, authenticated public channel with unlimited capacity is available to the source and destination for the secret sharing process. This situation is a special case of the “channel model with wiretapper” considered by Ahlswede and Csiszár. An extension of their result to continuous channel alphabets is employed to evaluate the key capacity of the fast-fading MIMO wiretap channel. The effects of spatial dimensionality provided by the use of multiple antennas at the source, destination, and eavesdropper are then investigated.

  11. On the secrecy capacity of the MISO wiretap channel under imperfect channel estimation

    KAUST Repository

    Rezki, Zouheir

    2014-12-01

    We consider a wiretap channel consisting of a source with multiple antennas, a legitimate receiver and an eavesdropper with a single antenna each. The channels between the source and the receivers undergo fast fading. We assume that the transmitter, in addition to the statistics of both channels, is only aware of a noisy version of the CSI to the legitimate receiver referred to as main channel. The legitimate receiver is aware of both its instantaneous channel gain and the transmitter\\'s estimate of the main channel. On the other hand, the eavesdropper\\'s receiver, in addition to its instantaneous channel realization, is aware of the actual main CSI and the transmitter\\'s estimate as well. While the capacity of this channel is still open even with perfect CSI at the transmitter, we provide in this paper upper and lower bounds on the secrecy capacity. The upper bound is tighter than the one corresponding to perfect main CSI and the gap between the two upper bounds is characterized in function of the channel estimation error variance, at high-SNR. Furthermore, we show that our upper and lower bounds coincide in the case of no main CSI providing a trivial secrecy capacity.

  12. A comparison of the aided performance and benefit provided by a linear and a two-channel wide dynamic range compression hearing aid.

    Science.gov (United States)

    Humes, L E; Christensen, L; Thomas, T; Bess, F H; Hedley-Williams, A; Bentler, R

    1999-02-01

    The aided performance and benefit achieved with linear and two-channel wide dynamic range compression (WDRC) in-the-canal (ITC) hearing aids were established in 55 individuals. Study participants had been wearing either linear or adaptive-frequency-response (Bass Increase at Low Levels, BILL) ITC hearing aids for approximately one year before participation in this study. Outcome measures included aided performance and objective benefit in quiet and noise at a variety of speech levels (50, 60, and 75 dB SPL), at various levels of babble background (quiet, signal-to-babble ratios of +5 and +10 dB), and for various types of test materials (monosyllabic words and sentences in connected speech). Several subjective measures of aided performance (sound-quality judgments and magnitude estimates of listening effort) and relative benefit (improvement in listening effort and the Hearing Aid Performance Inventory, HAPI) were also obtained. Finally, self-report measures of hearing-aid use were also obtained using daily logs. Participants completed all outcome measures for the linear ITC hearing aids first, following 2 months of usage, and then repeated all outcome measures for the WDRC instruments after a subsequent 2-month period of use. In general, although both types of hearing aids demonstrated significant benefit, the results indicated that the WDRC instruments were superior to the linear devices for many of the outcome measures. This tended to be the case most frequently when low speech levels were used. Many of the performance differences between devices most likely can be ascribed to differences in gain, and prescriptive approaches (DSL[i/o] vs. NAL-R), for the fixed volume control testing performed in this study.

  13. Adaptive OFDM and CDMA Algorithms for SISO and MIMO Channels

    NARCIS (Netherlands)

    Che, H.

    2005-01-01

    The objective of this thesis is to study adaptive modulation algorithms for Single Input Single Output (SISO) and Multiple Input Multiple Output (MIMO) channels. The adaptive modulation technique has the advantages of flexibility, providing high transmission quality and throughput; and it can lead

  14. Molecular biology of insect sodium channels and pyrethroid resistance.

    Science.gov (United States)

    Dong, Ke; Du, Yuzhe; Rinkevich, Frank; Nomura, Yoshiko; Xu, Peng; Wang, Lingxin; Silver, Kristopher; Zhorov, Boris S

    2014-07-01

    Voltage-gated sodium channels are essential for the initiation and propagation of the action potential in neurons and other excitable cells. Because of their critical roles in electrical signaling, sodium channels are targets of a variety of naturally occurring and synthetic neurotoxins, including several classes of insecticides. This review is intended to provide an update on the molecular biology of insect sodium channels and the molecular mechanism of pyrethroid resistance. Although mammalian and insect sodium channels share fundamental topological and functional properties, most insect species carry only one sodium channel gene, compared to multiple sodium channel genes found in each mammalian species. Recent studies showed that two posttranscriptional mechanisms, alternative splicing and RNA editing, are involved in generating functional diversity of sodium channels in insects. More than 50 sodium channel mutations have been identified to be responsible for or associated with knockdown resistance (kdr) to pyrethroids in various arthropod pests and disease vectors. Elucidation of molecular mechanism of kdr led to the identification of dual receptor sites of pyrethroids on insect sodium channels. Many of the kdr mutations appear to be located within or close to the two receptor sites. The accumulating knowledge of insect sodium channels and their interactions with insecticides provides a foundation for understanding the neurophysiology of sodium channels in vivo and the development of new and safer insecticides for effective control of arthropod pests and human disease vectors. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Molecular Biology of Insect Sodium Channels and Pyrethroid Resistance

    Science.gov (United States)

    Dong, Ke; Du, Yuzhe; Rinkevich, Frank; Nomura, Yoshiko; Xu, Peng; Wang, Lingxin; Silver, Kristopher; Zhorov, Boris S.

    2015-01-01

    Voltage-gated sodium channels are essential for the initiation and propagation of the action potential in neurons and other excitable cells. Because of their critical roles in electrical signaling, sodium channels are targets of a variety of naturally occurring and synthetic neurotoxins, including several classes of insecticides. This review is intended to provide an update on the molecular biology of insect sodium channels and the molecular mechanism of pyrethroid resistance. Although mammalian and insect sodium channels share fundamental topological and functional properties, most insect species carry only one sodium channel gene, compared to multiple sodium channel genes found in each mammalian species. Recent studies showed that two posttranscriptional mechanisms, alternative splicing and RNA editing, are involved in generating functional diversity of sodium channels in insects. More than 50 sodium channel mutations have been identified to be responsible for or associated with knockdown resistance (kdr) to pyrethroids in various arthropod pests and disease vectors. Elucidation of molecular mechanism of kdr led to the identification of dual receptor sites of pyrethroids on insect sodium channels. Most of the kdr mutations appear to be located within or close to the two receptor sites. The accumulating knowledge of insect sodium channels and their interactions with insecticides provides a foundation for understanding the neurophysiology of sodium channels in vivo and the development of new and safer insecticides for effective control of arthropod pests and human disease vectors. PMID:24704279

  16. An auroral westward flow channel (AWFC and its relationship to field-aligned current, ring current, and plasmapause location determined using multiple spacecraft observations

    Directory of Open Access Journals (Sweden)

    M. L. Parkinson

    2007-02-01

    Full Text Available An auroral westward flow channel (AWFC is a latitudinally narrow channel of unstable F-region plasma with intense westward drift in the dusk-to-midnight sector ionosphere. AWFCs tend to overlap the equatorward edge of the auroral oval, and their life cycle is often synchronised to that of substorms: they commence close to substorm expansion phase onset, intensify during the expansion phase, and then decay during the recovery phase. Here we define for the first time the relationship between an AWFC, large-scale field-aligned current (FAC, the ring current, and plasmapause location. The Tasman International Geospace Environment Radar (TIGER, a Southern Hemisphere HF SuperDARN radar, observed a jet-like AWFC during ~08:35 to 13:28 UT on 7 April 2001. The initiation of the AWFC was preceded by a band of equatorward expanding ionospheric scatter (BEES which conveyed an intense poleward electric field through the inner plasma sheet. Unlike previous AWFCs, this event was not associated with a distinct substorm surge; rather it occurred during an interval of persistent, moderate magnetic activity characterised by AL~−200 nT. The four Cluster spacecraft had perigees within the dusk sector plasmasphere, and their trajectories were magnetically conjugate to the radar observations. The Waves of High frequency and Sounder for Probing Electron density by Relaxation (WHISPER instruments on board Cluster were used to identify the plasmapause location. The Imager for Magnetopause-to-Aurora Global Exploration (IMAGE EUV experiment also provided global-scale observations of the plasmapause. The Cluster fluxgate magnetometers (FGM provided successive measurements specifying the relative location of the ring current and filamentary plasma sheet current. An analysis of Iridium spacecraft magnetometer measurements provided estimates of large-scale ionospheric FAC in relation to the AWFC evolution. Peak flows in the AWFC were located close to the peak of a Region 2

  17. Multiplet coupling and band structure in L{sub 2,3}-edge XAS through multi-channel multiple scattering theory

    Energy Technology Data Exchange (ETDEWEB)

    Krueger, Peter, E-mail: pkruger@u-bourgogne.f [ICB, UMR 5209 Universite de Bourgogne - CNRS, BP 47870, F-21078 Dijon (France)

    2009-11-15

    Using the recently developed multi-channel multiple scattering (MCMS) method we have calculated the x-ray absorption spectra (XAS) at the L{sub 2,3}-edge of transition metal compounds. The MCMS method is an ab initio scheme which combines an accurate description of the band structure of the material with a correlated many-electron wave function on the absorber atom. Thereby configuration interaction in the XAS final state, in particular multiplet effects, can be taken into account. In the present implementation, we use an electron-hole wave function and treat the interaction with all other electrons on a mean-field level. The calculated spectra agree well with experiment for the early transition metals (Ti,V), where the L2-L3 configuration mixing is particularly strong. We present a detailed study of titanium oxides with nominal Ti{sup 4+} ground state, namely rutile and anatase TiO{sub 2} and perovskite SrTiO{sub 3}. The XAS spectra display a rich fine structure with marked differences between the three systems despite the almost identical octahedral coordination of the Ti atom. The calculated spectra are in excellent agreement with the experimental data of all three compounds. As an example for a late 3d-metal we have studied the L{sub 2,3}-XAS and the x-ray magnetic circular dichroism (XMCD) of iron. In agreement with recent time-dependent density functional studies, we find that also for the late 3d elements, the particle-hole description can yield satisfactory L3/L2 branching ratios and lineshapes of the isotropic XAS spectrum if the screened monopole term of particle-hole Coulomb interaction is properly taken account for. The XMCD spectra of the same calculation are, however, less good than both atomic multiplet and one-electron spectra indicating clear limitations for the application of particle-hole theories to late 3d elements.

  18. FAST TRACK COMMUNICATION: From non-sequential to sequential strong-field multiple ionization: identification of pure and mixed reaction channels

    Science.gov (United States)

    Rudenko, A.; Ergler, Th; Zrost, K.; Feuerstein, B.; de Jesus, V. L. B.; Schröter, C. D.; Moshammer, R.; Ullrich, J.

    2008-04-01

    Momentum distributions of Ne3-4+ ions created by 795 nm, 25 fs laser pulses have been measured at 1015-2 × 1016 W cm-2 using a 'reaction microscope' in order to characterize the transition regime between non-sequential and sequential strong-field ionizations. We can clearly separate pure and/or mixed recollision-induced (e, ne)-like reactions and sequential (field-induced) processes, and observe transition intensities which agree with recently reported ion-yield data. Our results provide consistent qualitative description of Ne strong-field multiple ionization for all non-relativistic intensities.

  19. Convex approximations of quantum channels

    Science.gov (United States)

    Sacchi, Massimiliano F.; Sacchi, Tito

    2017-09-01

    We address the problem of optimally approximating the action of a desired and unavailable quantum channel Φ having at our disposal a single use of a given set of other channels {Ψi} . The problem is recast to look for the least distinguishable channel from Φ among the convex set ∑ipiΨi , and the corresponding optimal weights {pi} provide the optimal convex mixing of the available channels {Ψi} . For single-qubit channels we study specifically cases where the available convex set corresponds to covariant channels or to Pauli channels, and the desired target map is an arbitrary unitary transformation or a generalized damping channel.

  20. Compound Wiretap Channels

    Directory of Open Access Journals (Sweden)

    Kramer Gerhard

    2009-01-01

    Full Text Available Abstract This paper considers the compound wiretap channel, which generalizes Wyner's wiretap model to allow the channels to the (legitimate receiver and to the eavesdropper to take a number of possible states. No matter which states occur, the transmitter guarantees that the receiver decodes its message and that the eavesdropper is kept in full ignorance about the message. The compound wiretap channel can also be viewed as a multicast channel with multiple eavesdroppers, in which the transmitter sends information to all receivers and keeps the information secret from all eavesdroppers. For the discrete memoryless channel, lower and upper bounds on the secrecy capacity are derived. The secrecy capacity is established for the degraded channel and the semideterministic channel with one receiver. The parallel Gaussian channel is further studied. The secrecy capacity and the secrecy degree of freedom ( are derived for the degraded case with one receiver. Schemes to achieve the for the case with two receivers and two eavesdroppers are constructed to demonstrate the necessity of a prefix channel in encoder design. Finally, the multi-antenna (i.e., MIMO compound wiretap channel is studied. The secrecy capacity is established for the degraded case and an achievable is given for the general case.

  1. The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

    Directory of Open Access Journals (Sweden)

    Lonneke van der Linden

    2015-03-01

    Full Text Available The genus Enterovirus of the family Picornaviridae contains many important human pathogens (e.g., poliovirus, coxsackievirus, rhinovirus, and enterovirus 71 for which no antiviral drugs are available. The viral RNA-dependent RNA polymerase is an attractive target for antiviral therapy. Nucleoside-based inhibitors have broad-spectrum activity but often exhibit off-target effects. Most non-nucleoside inhibitors (NNIs target surface cavities, which are structurally more flexible than the nucleotide-binding pocket, and hence have a more narrow spectrum of activity and are more prone to resistance development. Here, we report a novel NNI, GPC-N114 (2,2'-[(4-chloro-1,2-phenylenebis(oxy]bis(5-nitro-benzonitrile with broad-spectrum activity against enteroviruses and cardioviruses (another genus in the picornavirus family. Surprisingly, coxsackievirus B3 (CVB3 and poliovirus displayed a high genetic barrier to resistance against GPC-N114. By contrast, EMCV, a cardiovirus, rapidly acquired resistance due to mutations in 3Dpol. In vitro polymerase activity assays showed that GPC-N114 i inhibited the elongation activity of recombinant CVB3 and EMCV 3Dpol, (ii had reduced activity against EMCV 3Dpol with the resistance mutations, and (iii was most efficient in inhibiting 3Dpol when added before the RNA template-primer duplex. Elucidation of a crystal structure of the inhibitor bound to CVB3 3Dpol confirmed the RNA-binding channel as the target for GPC-N114. Docking studies of the compound into the crystal structures of the compound-resistant EMCV 3Dpol mutants suggested that the resistant phenotype is due to subtle changes that interfere with the binding of GPC-N114 but not of the RNA template-primer. In conclusion, this study presents the first NNI that targets the RNA template channel of the picornavirus polymerase and identifies a new pocket that can be used for the design of broad-spectrum inhibitors. Moreover, this study provides important new insight

  2. Radar channel balancing with commutation

    Energy Technology Data Exchange (ETDEWEB)

    Doerry, Armin Walter

    2014-02-01

    When multiple channels are employed in a pulse-Doppler radar, achieving and maintaining balance between the channels is problematic. In some circumstances the channels may be commutated to achieve adequate balance. Commutation is the switching, trading, toggling, or multiplexing of the channels between signal paths. Commutation allows modulating the imbalance energy away from the balanced energy in Doppler, where it can be mitigated with filtering.

  3. A survey of the application of the spherical vector wave mode expansion approach to antenna-channel interaction modeling

    Science.gov (United States)

    Alayon Glazunov, Andrés.

    2014-08-01

    This paper provides an overview of recent advances in the modeling, analysis, and measurements of interactions between antennas and the propagation channel in multiple antenna systems based on the spherical vector wave mode expansion of the electromagnetic field and the antenna scattering matrix. It demonstrates the importance and usefulness of this approach to gain further insights into a variety of topics such as physics-based propagation channel modeling, mean effective gain, channel correlation, propagation channel measurements, antenna measurements and testing, the number of degrees of freedom of the radio propagation channel, channel throughput, and diversity systems. The paper puts particular emphasis on the unified approach to antenna-channel analysis at the same time as the antenna and the channel influence are separated. Finally, the paper provides the first bibliography on the application of the spherical vector wave mode expansion of the electromagnetic field to antenna-channel interactions.

  4. The 3 A's of the access process to long-term care for elderly: providers experiences in a multiple case study in the Netherlands.

    Science.gov (United States)

    Schipper, Lisette; Luijkx, Katrien; Meijboom, Bert; Schols, Jos

    2015-01-01

    The access process is an important step in the care provision to independently living elderly. Still, little attention has been given to the process of access to long-term care for older clients. Access can be described by three dimensions: availability, affordability and acceptability (three A's). In this paper we address the following question: How do care providers take the three dimensions of access into account for the access process to their care and related service provision to independently living elderly? To answer this question we performed a qualitative study. We used data gathered in a multiple case study in the Netherlands. This study provides insight in the way long-term care organizations organize their access process. Not all dimensions were equally present or acknowledged by the case organizations. The dimension acceptability seems an important dimension in the access process, as shown by the efforts done in building a relationship with their clients, mainly through a strong personal relationship between client and care advisor. In that respect it is remarkable that the case organizations do not structurally evaluate their access process. Availability is compromised by practical issues and organizational choices. Affordability hardly seems an issue. Further research can reveal the underlying factors that influence the three A dimensions. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  5. Channel and Timeslot Co-Scheduling with Minimal Channel Switching for Data Aggregation in MWSNs

    OpenAIRE

    Sanggil Yeoum; Byungseok Kang; Jinkyu Lee; Hyunseung Choo

    2017-01-01

    Collision-free transmission and efficient data transfer between nodes can be achieved through a set of channels in multichannel wireless sensor networks (MWSNs). While using multiple channels, we have to carefully consider channel interference, channel and time slot (resources) optimization, channel switching delay, and energy consumption. Since sensor nodes operate on low battery power, the energy consumed in channel switching becomes an important challenge. In this paper, we propose channel...

  6. Creating a Community of Practice to Prevent Suicide Through Multiple Channels: Describing the Theoretical Foundations and Structured Learning of PC CARES.

    Science.gov (United States)

    Wexler, Lisa; McEachern, Diane; DiFulvio, Gloria; Smith, Cristine; Graham, Louis F; Dombrowski, Kirk

    2016-01-01

    It is critical to develop practical, effective, ecological, and decolonizing approaches to indigenous suicide prevention and health promotion for the North American communities. The youth suicide rates in predominantly indigenous small, rural, and remote Northern communities are unacceptably high. This health disparity, however, is fairly recent, occurring over the last 50 to 100 years as communities experienced forced social, economic, and political change and intergenerational trauma. These conditions increase suicide risk and can reduce people's access to shared protective factors and processes. In this context, it is imperative that suicide prevention includes--at its heart--decolonization, while also utilizing the "best practices" from research to effectively address the issue from multiple levels. This article describes such an approach: Promoting Community Conversations About Research to End Suicide (PC CARES). PC CARES uses popular education strategies to build a "community of practice" among local and regional service providers, friends, and families that fosters personal and collective learning about suicide prevention in order to spur practical action on multiple levels to prevent suicide and promote health. This article will discuss the theoretical underpinnings of the community intervention and describe the form that PC CARES takes to structure ongoing dialogue, learning, solidarity, and multilevel mobilization for suicide prevention. © The Author(s) 2016.

  7. Micro-channel plate detector

    Science.gov (United States)

    Elam, Jeffrey W.; Lee, Seon W.; Wang, Hsien -Hau; Pellin, Michael J.; Byrum, Karen; Frisch, Henry J.

    2015-09-22

    A method and system for providing a micro-channel plate detector. An anodized aluminum oxide membrane is provided and includes a plurality of nanopores which have an Al coating and a thin layer of an emissive oxide material responsive to incident radiation, thereby providing a plurality of radiation sensitive channels for the micro-channel plate detector.

  8. Healthcare provider relational quality is associated with better self-management and less treatment burden in people with multiple chronic conditions

    Directory of Open Access Journals (Sweden)

    Eton DT

    2017-09-01

    Full Text Available David T Eton,1,2 Jennifer L Ridgeway,1,2 Mark Linzer,3 Deborah H Boehm,4 Elizabeth A Rogers,5 Kathleen J Yost,1,2 Lila J Finney Rutten,1,2 Jennifer L St Sauver,1,2 Sara Poplau,4 Roger T Anderson6 1Department of Health Sciences Research, 2Robert D and Patricia E Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, 3Division of General Internal Medicine, Hennepin County Medical Center, 4Minneapolis Medical Research Foundation, 5Division of General Internal Medicine, University of Minnesota Medical School, Minneapolis, MN, 6Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA Purpose: Having multiple chronic conditions (MCCs can lead to appreciable treatment and self-management burden. Healthcare provider relational quality (HPRQ – the communicative and interpersonal skill of the provider – may mitigate treatment burden and promote self-management. The objectives of this study were to 1 identify the associations between HPRQ, treatment burden, and psychosocial outcomes in adults with MCCs, and 2 determine if certain indicators of HPRQ are more strongly associated than others with these outcomes.Patients and methods: This is a cross-sectional survey study of 332 people with MCCs. Patients completed a 7-item measure of HPRQ and measures of treatment and self-management burden, chronic condition distress, self-efficacy, provider satisfaction, medication adherence, and physical and mental health. Associations between HPRQ, treatment burden, and psychosocial outcomes were determined using correlational analyses and independent samples t-tests, which were repeated in item-level analyses to explore which indicators of HPRQ were most strongly associated with the outcomes.Results: Most respondents (69% were diagnosed with ≥3 chronic conditions. Better HPRQ was found to be associated with less treatment and self-management burden and better psychosocial outcomes (P<0

  9. Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegypti

    Directory of Open Access Journals (Sweden)

    Yuzhe Du

    2016-10-01

    Full Text Available Pyrethroid insecticides are widely used to control insect pests and human disease vectors. Voltage-gated sodium channels are the primary targets of pyrethroid insecticides. Mutations in the sodium channel have been shown to be responsible for pyrethroid resistance, known as knockdown resistance (kdr, in various insects including mosquitoes. In Aedes aegypti mosquitoes, the principal urban vectors of dengue, zika, and yellow fever viruses, multiple single nucleotide polymorphisms in the sodium channel gene have been found in pyrethroid-resistant populations and some of them have been functionally confirmed to be responsible for kdr in an in vitro expression system, Xenopus oocytes. This mini-review aims to provide an update on the identification and functional characterization of pyrethroid resistance-associated sodium channel mutations from Aedes aegypti. The collection of kdr mutations not only helped us develop molecular markers for resistance monitoring, but also provided valuable information for computational molecular modeling of pyrethroid receptor sites on the sodium channel.

  10. Evaluation and mechanism for outcomes exploration of providing public health care in contract service in rural China: a multiple-case study with complex adaptive systems design.

    Science.gov (United States)

    Zhou, Huixuan; Zhang, Shengfa; Zhang, Weijun; Wang, Fugang; Zhong, You; Gu, Linni; Qu, Zhiyong; Tian, Donghua

    2015-02-27

    The Chinese government has increased the funding for public health in 2009 and experimentally applied a contract service policy (could be seen as a counterpart to family medicine) in 15 counties to promote public health services in the rural areas in 2013. The contract service aimed to convert village doctors, who had privately practiced for decades, into general practitioners under the government management, and better control the rampant chronic diseases. This study made a rare attempt to assess the effectiveness of public health services delivered under the contract service policy, explore the influencing mechanism and draw the implications for the policy extension in the future. Three pilot counties and a non-pilot one with heterogeneity in economic and health development from east to west of China were selected by a purposive sampling method. The case study methods by document collection, non-participant observation and interviews (including key informant interview and focus group interview) with 84 health providers and 20 demanders in multiple level were applied in this study. A thematic approach was used to compare diverse outcomes and analyze mechanism in the complex adaptive systems framework. Without sufficient incentives, the public health services were not conducted effectively, regardless of the implementation of the contract policy. To appropriately increase the funding for public health by local finance and properly allocate subsidy to village doctors was one of the most effective approaches to stimulate health providers and demanders' positivity and promote the policy implementation. County health bureaus acted as the most crucial agents among the complex public health systems. Their mental models influenced by the compound and various environments around them led to the diverse outcomes. If they could provide extra incentives and make the contexts of the systems ripe enough for change, the health providers and demanders would be receptive to the

  11. Effective capacity of correlated MISO channels

    KAUST Repository

    Zhong, Caijun

    2011-06-01

    This paper presents an analytical performance investigation of the capacity limits of correlated multiple-input single-output (MISO) channels in the presence of quality-of-service (QoS) requirements. Exact closed-form expression for the effective capacity of correlated MISO channels is derived. In addition, simple expressions are obtained at the asymptotic high and low signal-to-noise ratio (SNR) regimes, which provide insights into the impact of various system parameters on the effective capacity of the system. Also, a complete characterization of the impact of spatial correlation on the effective capacity is provided with the aid of a majorization theory result. The findings suggest that antenna correlation reduce the effective capacity of the channels. Moreover, a stringent QoS requirement causes a significant reduction in the effective capacity but this can be effectively alleviated by increasing the number of antennas. © 2011 IEEE.

  12. Modeling the vehicle-to-vehicle propagation channel: A review

    Science.gov (United States)

    Matolak, David W.

    2014-09-01

    In this paper we provide a review of the vehicle-to-vehicle (V2V) wireless propagation channel. This "car-to-car" application will be used to improve roadway efficiency, provide unique traveler services, and can also enable safety applications that can save lives. We briefly review some currently envisioned applications and the initial V2V radio technology, then address the V2V propagation channel. Propagation basics germane to the V2V setting are described, followed by a discussion of channel dispersion and time variation. The channel impulse response and its Fourier transform, the channel transfer function, are described in detail, and their common statistical characterizations are also reviewed. The most common models for the V2V channel—the tapped delay line and geometry-based stochastic channel models—are covered in some detail. We highlight key differences between the V2V channel and the well-known cellular radio channel. These differences are the more rapid time variation and the higher probability of obstruction of the direct line of sight component; modeling of these effects has required some novel approaches. The V2V channel's nonstationary statistical behavior is addressed, as is the use of multiple-antenna systems. The remaining areas for future work are also described.

  13. BER Analysis of Various Channel Equalization Schemes of a QO-STBC Encoded OFDM based MIMO CDMA System

    OpenAIRE

    Husnul Ajra; Md. Zahid Hasan; Md. Shohidul Islam

    2014-01-01

    Quasi Orthogonal Space Time Block Code (QO-STBC) can provide full-rate transmission and low decoding complexity. This paper deals with channel estimation for Quasi Orthogonal Space Time Block Code (QO-STBC) encoded Orthogonal Frequency Division Multiplexing (OFDM) based Multiple Input multiple Output (MIMO) Code Division Multiple Access (CDMA) system. Using the QO-STBC coding property, we analysis the weight performance that reduce the computational complexity of system. The design of channel...

  14. On the secrecy capacity of the broadcast wiretap channel with imperfect channel state information

    KAUST Repository

    Hyadi, Amal

    2014-12-01

    In this paper, we consider secure broadcasting over fast fading channels. Assuming imperfect main channel state information (CSI) at the transmitter, we first provide an upper and a lower bounds on the ergodic secrecy capacity when a common message is broadcasted to multiple legitimate receivers in the presence of one eavesdropper. For this case, we show that the secrecy rate is limited by the legitimate receiver having, on average, the worst main channel link. Then, we present an expression for the achievable secrecy sum-rate when each legitimate receiver is interested in an independent message. The special cases of high SNR, perfect and no-main CSI are also analyzed. Numerical results are presented to illustrate the obtained results for the case of independent but not necessarily identically distributed Rayleigh fading channels.

  15. A Reliable Channel Reservation based Multi-channel MAC Protocol with A Single Transceiver

    OpenAIRE

    Bo Yang; Bo Li; Zhongjiang Yan; Mao Yang; Xiaoya Zuo

    2015-01-01

    The multi-channel MAC protocols have been proposed recently to improve the network capacity by accommodating more concurrent transmissions. In this paper, we propose a distributed multi-channel MAC protocol using reliable multiple channel reservation with only a single transceiver. Specifically, the control handshake information is reserved to be re-broadcasted over the control channel to address the multi-channel hidden terminal problem. Besides, by reserving multiple data transmission oppor...

  16. Performance of Channel Estimation in MIMO-OFDM Systems

    Directory of Open Access Journals (Sweden)

    Subuh Pramono

    2013-07-01

    Full Text Available This paper presented the performance of faded channel estimation method on orthogonal frequency division multiplexing-multiple input multiple output (OFDM-MIMO i.e. least squares (LS and minimum mean squared error (MMSE. Channel impuls response (CIR was required to overcome the intersymbol interference (ISI. Channel impuls response information was obtained from channel estimation processing. Iterance simulation used monte-carlo technique to determined the performance of bit error rate (BER and mean squared error(MSE. Simulation results show that the mean squared error performance on MIMO system was better than the SISO system.On MMSE channel estimation, the MIMO 2Tx-2Rx system provided 2 dB improvement that compared to SISO system at value of MSE 10-2. Furthermore, MIMO 3Tx-2Rx produce improvement about 1.5 dB, MIMO 4Tx-2Rx improve about 3.5 dB at BER 10-4, respectively. The MIMO 2Tx-2Rx system, MMSE channel estimation produced better performance 1 dB than LS channel estimation with sufficient SNR value for MSE 10-2 . Pilot arrangement, the simulation results show that the block type-pilot arrangement produced better performance than the comb type-pilot arrangement at fast fading channel. Block type-pilot arrangement system produced better 10 dB than the comb type-pilot arrangement with MMSE method at value of BER 2 10-2

  17. Two-point versus multiple-point geostatistics: the ability of geostatistical methods to capture complex geobodies and their facies associations—an application to a channelized carbonate reservoir, southwest Iran

    Science.gov (United States)

    Hashemi, Seyyedhossein; Javaherian, Abdolrahim; Ataee-pour, Majid; Khoshdel, Hossein

    2014-12-01

    Facies models try to explain facies architectures which have a primary control on the subsurface heterogeneities and the fluid flow characteristics of a given reservoir. In the process of facies modeling, geostatistical methods are implemented to integrate different sources of data into a consistent model. The facies models should describe facies interactions; the shape and geometry of the geobodies as they occur in reality. Two distinct categories of geostatistical techniques are two-point and multiple-point (geo) statistics (MPS). In this study, both of the aforementioned categories were applied to generate facies models. A sequential indicator simulation (SIS) and a truncated Gaussian simulation (TGS) represented two-point geostatistical methods, and a single normal equation simulation (SNESIM) selected as an MPS simulation representative. The dataset from an extremely channelized carbonate reservoir located in southwest Iran was applied to these algorithms to analyze their performance in reproducing complex curvilinear geobodies. The SNESIM algorithm needs consistent training images (TI) in which all possible facies architectures that are present in the area are included. The TI model was founded on the data acquired from modern occurrences. These analogies delivered vital information about the possible channel geometries and facies classes that are typically present in those similar environments. The MPS results were conditioned to both soft and hard data. Soft facies probabilities were acquired from a neural network workflow. In this workflow, seismic-derived attributes were implemented as the input data. Furthermore, MPS realizations were conditioned to hard data to guarantee the exact positioning and continuity of the channel bodies. A geobody extraction workflow was implemented to extract the most certain parts of the channel bodies from the seismic data. These extracted parts of the channel bodies were applied to the simulation workflow as hard data. This

  18. Applied light-side coupling with optimized spiral-patterned zinc oxide nanorod coatings for multiple optical channel alcohol vapor sensing

    Science.gov (United States)

    Bin Abdul Rahim, Hazli Rafis; Bin Lokman, Muhammad Quisar; Harun, Sulaiman Wadi; Hornyak, Gabor Louis; Sterckx, Karel; Mohammed, Waleed Soliman; Dutta, Joydeep

    2016-07-01

    The width of spiral-patterned zinc oxide (ZnO) nanorod coatings on plastic optical fiber (POF) was optimized theoretically for light-side coupling and found to be 5 mm. Structured ZnO nanorods were grown on large core POFs for the purpose of alcohol vapor sensing. The aim of the spiral patterns was to enhance signal transmission by reduction of the effective ZnO growth area, thereby minimizing light leakage due to backscattering. The sensing mechanism utilized changes in the output signal due to adsorption of methanol, ethanol, and isopropanol vapors. Three spectral bands consisting of red (620 to 750 nm), green (495 to 570 nm), and blue (450 to 495 nm) were applied in measurements. The range of relative intensity modulation (RIM) was determined to be for concentrations between 25 to 300 ppm. Methanol presented the strongest response compared to ethanol and isopropanol in all three spectral channels. With regard to alcohol detection RIM by spectral band, the green channel demonstrated the highest RIM values followed by the blue and red channels, respectively.

  19. Secure Broadcasting with Uncertain Channel State Information

    KAUST Repository

    Hyadi, Amal

    2017-03-13

    We investigate the problem of secure broadcasting over fast fading channels with imperfect main channel state information (CSI) at the transmitter. In particular, we analyze the effect of the noisy estimation of the main CSI on the throughput of a broadcast channel where the transmission is intended for multiple legitimate receivers in the presence of an eavesdropper. Besides, we consider the realistic case where the transmitter is only aware of the statistics of the eavesdropper\\'s CSI and not of its channel\\'s realizations. First, we discuss the common message transmission case where the source broadcasts the same information to all the receivers, and we provide an upper and a lower bounds on the ergodic secrecy capacity. For this case, we show that the secrecy rate is limited by the legitimate receiver having, on average, the worst main channel link and we prove that a non-zero secrecy rate can still be achieved even when the CSI at the transmitter is noisy. Then, we look at the independent messages case where the transmitter broadcasts multiple messages to the receivers, and each intended user is interested in an independent message. For this case, we present an expression for the achievable secrecy sum-rate and an upper bound on the secrecy sum-capacity and we show that, in the limit of large number of legitimate receivers K, our achievable secrecy sum-rate follows the scaling law log((1-a ) log(K)), where is the estimation error variance of the main CSI. The special cases of high SNR, perfect and no-main CSI are also analyzed. Analytical derivations and numerical results are presented to illustrate the obtained expressions for the case of independent and identically distributed Rayleigh fading channels.

  20. Efficient coordinated recovery of sparse channels in massive MIMO

    KAUST Repository

    Masood, Mudassir

    2015-01-01

    This paper addresses the problem of estimating sparse channels in massive MIMO-OFDM systems. Most wireless channels are sparse in nature with large delay spread. In addition, these channels as observed by multiple antennas in a neighborhood have approximately common support. The sparsity and common support properties are attractive when it comes to the efficient estimation of large number of channels in massive MIMO systems. Moreover, to avoid pilot contamination and to achieve better spectral efficiency, it is important to use a small number of pilots. We present a novel channel estimation approach which utilizes the sparsity and common support properties to estimate sparse channels and requires a small number of pilots. Two algorithms based on this approach have been developed that perform Bayesian estimates of sparse channels even when the prior is non-Gaussian or unknown. Neighboring antennas share among each other their beliefs about the locations of active channel taps to perform estimation. The coordinated approach improves channel estimates and also reduces the required number of pilots. Further improvement is achieved by the data-aided version of the algorithm. Extensive simulation results are provided to demonstrate the performance of the proposed algorithms.

  1. Improved multiple-locus variable-number tandem-repeat assay for Staphylococcus aureus genotyping, providing a highly informative technique together with strong phylogenetic value

    NARCIS (Netherlands)

    Pourcel, Christine; Hormigos, Katia; Onteniente, Lucie; Sakwinska, Olga; Deurenberg, Ruud H; Vergnaud, Gilles

    2009-01-01

    We describe an improved multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA) scheme for genotyping Staphylococcus aureus. We compare its performance to those of multilocus sequence typing (MLST) and spa typing in a survey of 309 strains. This collection includes 87 epidemic

  2. Belief Propagation based MIMO Detection Operating on Quantized Channel Output

    CERN Document Server

    Mezghani, Amine

    2010-01-01

    In multiple-antenna communications, as bandwidth and modulation order increase, system components must work with demanding tolerances. In particular, high resolution and high sampling rate analog-to-digital converters (ADCs) are often prohibitively challenging to design. Therefore ADCs for such applications should be low-resolution. This paper provides new insights into the problem of optimal signal detection based on quantized received signals for multiple-input multiple-output (MIMO) channels. It capitalizes on previous works which extensively analyzed the unquantized linear vector channel using graphical inference methods. In particular, a "loopy" belief propagation-like (BP) MIMO detection algorithm, operating on quantized data with low complexity, is proposed. In addition, we study the impact of finite receiver resolution in fading channels in the large-system limit by means of a state evolution analysis of the BP algorithm, which refers to the limit where the number of transmit and receive antennas go t...

  3. Low-Complexity Interference-Free Downlink Channel Assignment with Improved Performance in Coordinated Small Cells

    KAUST Repository

    Radaydeh, Redha M.

    2015-05-01

    This paper proposes a low-complexity interference-free channel assignment scheme with improved desired downlink performance in coordinated multi-antenna small-coverage access points (APs) that employ the open-access control strategy. The adopted system treats the case when each user can be granted an access to one of the available channels at a time. Moreover, each receive terminal can suppress a limited number of resolvable interfering sources via its highly-correlated receive array. On the other hand, the operation of the deployed APs can be coordinated to serve active users, and the availability of multiple physical channels and the use of uncorrelated transmit antennas at each AP are exploited to improve the performance of supported users. The analysis provides new approaches to use the transmit antenna array at each AP, the multiple physical channels, the receive antenna array at each user in order to identify interference-free channels per each user, and then to select a downlink channel that provides the best possible improved performance. The event of concurrent interference-free channel identification by different users is also treated to further improve the desired link associated with the scheduled user. The analysis considers the practical scenario of imperfect identification of interference-free channel by an active user and/or the imperfectness in scheduling concurrent users requests on the same channel. The developed formulations can be used to study any performance metric and they are applicable for any statistical and geometric channel models. © 2015 IEEE.

  4. Coding for optical channels

    CERN Document Server

    Djordjevic, Ivan; Vasic, Bane

    2010-01-01

    This unique book provides a coherent and comprehensive introduction to the fundamentals of optical communications, signal processing and coding for optical channels. It is the first to integrate the fundamentals of coding theory and optical communication.

  5. Imperfect Channel State Estimation

    Directory of Open Access Journals (Sweden)

    Tao Qin

    2010-01-01

    in a multiuser OFDM CR system. A simple back-off scheme is proposed, and simulation results are provided which show that the proposed scheme is very effective in mitigating the negative impact of channel estimation errors.

  6. Information-guided communications in MIMO systems with channel state impairments

    KAUST Repository

    Yang, Yuli

    2013-06-20

    Information-guided channel hopping (IGCH) is a promising technique for high-data-rate communications using multiple antennas for information mapping at the transmitter and optional antenna diversity at the receiver. Compared with some popular multi-antenna techniques, the advantage of this scheme is proven in ideal channel conditions, where the channel is spatially white and the perfect channel state information is assumed available at the receiver. The main objective of this paper is to present an information theoretical study on IGCH in realistic propagation environments with channel degeneracy due to spatial correlation and keyhole phenomena as well as imperfect channel estimation. It is proven that good performance promised by IGCH can be achieved in a variety of non-ideal channel conditions. Moreover, the analysis in this paper provides a convenient tool for the corresponding system design in practical operating environments. © 2013 John Wiley & Sons, Ltd.

  7. Odontoblasts in developing, mature and ageing rat teeth have multiple phenotypes that variably express all nine voltage-gated sodium channels.

    Science.gov (United States)

    Byers, Margaret R; Westenbroek, Ruth E

    2011-11-01

    Our goal was to evaluate the expression patterns for voltage gated sodium channels in odontoblasts of developing and mature rat teeth. We analysed immunoreactivity (IR) of the alpha subunit for all nine voltage gated sodium channels (Nav1.1-1.9) in teeth of immature (4 weeks), young adult (7 weeks), fully mature adult (3 months), and old rats (6-12 months). We were interested in developmental changes, crown/root differences, tetrodotoxin sensitivity or resistance, co-localization with nerve regions, occurrence in periodontium, and coincidence with other expression patterns by odontoblasts such as for transient receptor potential A1 (TRPA1). We found that Nav1.1-1.9-IR each had unique odontoblast patterns in mature molars that all differed from developmental stages and from incisors. Nav1.4- and Nav1.7-IR were intense in immature odontoblasts, becoming limited to specific zones in adults. Crown odontoblasts lost Nav1.7-IR and gained Nav1.8-IR where dentine became innervated. Odontoblast staining for Nav1.1- and Nav1.5-IR increased in crown with age but decreased in roots. Nav1.9-IR was especially intense in regularly scattered odontoblasts. Two tetrodotoxin-resistant isoforms (Nav1.5, Nav1.8) had strong expression in odontoblasts near dentinal innervation zones. Nav1.6-IR was concentrated at intercusp and cervical odontoblasts in adults as was TRPA1-IR. Nav1.3-IR gradually became intense in all odontoblasts during development except where dentinal innervation was dense. All nine voltage-gated sodium channels could be expressed by odontoblasts, depending on intradental location and tooth maturity. Our data reveal much greater complexity and niche-specific specialization for odontoblasts than previously demonstrated, with implications for tooth sensitivity. Copyright © 2011 Elsevier Ltd. All rights reserved.

  8. Transport-Relevant Protein Conformational Dynamics and Water Dynamics on Multiple Timescales in an Archetypal Proton Channel - Insights from Solid-State NMR.

    Science.gov (United States)

    Mandala, Venkata; Gelenter, Martin D; Hong, Mei

    2018-01-05

    The influenza M2 protein forms a tetrameric proton channel that conducts protons from the acidic endosome into the virion by shuttling protons between water and a transmembrane histidine. Previous NMR studies have shown that this histidine protonates and deprotonates on the microsecond timescale. However, M2's proton conduction rate is 10 - 1000 s-1, more than two orders of magnitude slower than the histidine-water proton-exchange rate. M2 is also known to be conformationally plastic. To address the disparity between the functional timescale and the timescales of protein conformational dynamics and water dynamics, we have now investigated a W41F mutant of the M2 transmembrane domain using solid-state NMR. 13C chemical shifts of the membrane-bound peptide indicate the presence of two distinct tetramer conformations, whose concentrations depend exclusively on pH and hence the charge-state distribution of the tetramers. High-temperature 2D correlation spectra indicate that these two conformations interconvert at a rate of ~400 s-1 when the +2 and +3 charge states dominate, which gives the first experimental evidence of protein conformational motion on the transport timescale. Protein 13C-detected water 1H T2 relaxation measurements show that channel water relaxes an order of magnitude faster than bulk water and membrane-associated water, indicating that channel water undergoes nanosecond motion in a pH-independent fashion. These results connect motions on three timescales to explain M2's proton-conduction mechanism: picosecond-to-nanosecond motions of water molecules facilitate proton Grotthuss hopping, microsecond motions of the histidine sidechain allow water-histidine proton transfer, while millisecond motions of the entire four-helix bundle constitute the rate-limiting step, dictating the number of protons released into the virion.

  9. Short-Term Facilitation at a Detonator Synapse Requires the Distinct Contribution of Multiple Types of Voltage-Gated Calcium Channels.

    Science.gov (United States)

    Chamberland, Simon; Evstratova, Alesya; Tóth, Katalin

    2017-05-10

    Neuronal calcium elevations are shaped by several key parameters, including the properties, density, and the spatial location of voltage-gated calcium channels (VGCCs). These features allow presynaptic terminals to translate complex firing frequencies and tune the amount of neurotransmitter released. Although synchronous neurotransmitter release relies on both P/Q- and N-type VGCCs at hippocampal mossy fiber-CA3 synapses, the specific contribution of VGCCs to calcium dynamics, neurotransmitter release, and short-term facilitation remains unknown. Here, we used random-access two-photon calcium imaging together with electrophysiology in acute mouse hippocampal slices to dissect the roles of P/Q- and N-type VGCCs. Our results show that N-type VGCCs control glutamate release at a limited number of release sites through highly localized Ca 2+ elevations and support short-term facilitation by enhancing multivesicular release. In contrast, Ca 2+ entry via P/Q-type VGCCs promotes the recruitment of additional release sites through spatially homogeneous Ca 2+ elevations. Altogether, our results highlight the specialized contribution of P/Q- and N-types VGCCs to neurotransmitter release. SIGNIFICANCE STATEMENT In presynaptic terminals, neurotransmitter release is dynamically regulated by the transient opening of different types of voltage-gated calcium channels. Hippocampal giant mossy fiber terminals display extensive short-term facilitation during repetitive activity, with a large several fold postsynaptic response increase. Though, how giant mossy fiber terminals leverage distinct types of voltage-gated calcium channels to mediate short-term facilitation remains unexplored. Here, we find that P/Q- and N-type VGCCs generate different spatial patterns of calcium elevations in giant mossy fiber terminals and support short-term facilitation through specific participation in two mechanisms. Whereas N-type VGCCs contribute only to the synchronization of multivesicular release

  10. Statistical analysis on finger replacement schemes for RAKE receivers in the soft handover region with multiple BSs over i.n.d. fading channels

    KAUST Repository

    Nam, Sung Sik

    2017-06-12

    A new finger replacement technique which is applicable for RAKE receivers in the soft handover region has been proposed and studied under the ideal assumption that the fading is both independent and identically distributed from path to path. To supplement our previous work, we present a general comprehensive framework for the performance assessment of the proposed finger replacement schemes operating over independent but non-identically distributed (i.n.d.) faded paths. To accomplish this object, we derive new closed-form expressions for the target key statistics which are composed of i.n.d. exponential random variables. With these new expressions, the performance analysis of various wireless communication systems over more practical channel environments can be possible.

  11. Ablation of Ca(V2.1 voltage-gated Ca²⁺ channels in mouse forebrain generates multiple cognitive impairments.

    Directory of Open Access Journals (Sweden)

    Robert Theodor Mallmann

    Full Text Available Voltage-gated Ca(V2.1 (P/Q-type Ca²⁺ channels located at the presynaptic membrane are known to control a multitude of Ca²⁺-dependent cellular processes such as neurotransmitter release and synaptic plasticity. Our knowledge about their contributions to complex cognitive functions, however, is restricted by the limited adequacy of existing transgenic Ca(V2.1 mouse models. Global Ca(V2.1 knock-out mice lacking the α1 subunit Cacna1a gene product exhibit early postnatal lethality which makes them unsuitable to analyse the relevance of Ca(V2.1 Ca²⁺ channels for complex behaviour in adult mice. Consequently we established a forebrain specific Ca(V2.1 knock-out model by crossing mice with a floxed Cacna1a gene with mice expressing Cre-recombinase under the control of the NEX promoter. This novel mouse model enabled us to investigate the contribution of Ca(V2.1 to complex cognitive functions, particularly learning and memory. Electrophysiological analysis allowed us to test the specificity of our conditional knock-out model and revealed an impaired synaptic transmission at hippocampal glutamatergic synapses. At the behavioural level, the forebrain-specific Ca(V2.1 knock-out resulted in deficits in spatial learning and reference memory, reduced recognition memory, increased exploratory behaviour and a strong attenuation of circadian rhythmicity. In summary, we present a novel conditional Ca(V2.1 knock-out model that is most suitable for analysing the in vivo functions of Ca(V2.1 in the adult murine forebrain.

  12. Secure Broadcasting with Uncertain Channel State Information

    KAUST Repository

    Hyadi, Amal

    2016-01-06

    We investigate the problem of secure broadcasting over fast fading channels with imperfect main channel state information (CSI) at the transmitter. In particular, we analyze the effect of the noisy estimation of the main CSI on the throughput of a broadcast channel where the transmission is intended for multiple legitimate receivers in the presence of an eavesdropper. Besides, we consider the realistic case where the transmitter is only aware of the statistics of the eavesdropper s CSI and not of its channel s realizations. First, we discuss the common message transmission case where the source broadcasts the same information to all the receivers, and we provide an upper and a lower bounds on the ergodic secrecy capacity. For this case, we show that the secrecy rate is limited by the legitimate receiver having, on average, the worst main channel link and we prove that a non-zero secrecy rate can still be achieved even when the CSI at the transmitter is noisy. Then, we look at the independent messages case where the transmitter broadcasts multiple messages to the receivers, and each intended user is interested in an independent message. For this case, we present an expression for the achievable secrecy sum-rate and an upper bound on the secrecy sum-capacity and we show that, in the limit of large number of legitimate receivers K, our achievable secrecy sum-rate follows the scaling law log((1-a ) log(K)), where is the estimation error variance of the main CSI. The special cases of high SNR, perfect and no-main CSI are also analyzed. Analytical derivations and numerical results are presented to illustrate the obtained expressions for the case of independent and identically distributed Rayleigh fading channels.

  13. Achievable Rates of Secure Transmission in Gaussian MISO Channel with Imperfect Main Channel Estimation

    KAUST Repository

    Zhou, Xinyu

    2016-03-15

    A Gaussian multiple-input single-output (MISO) fading channel is considered. We assume that the transmitter, in addition to the statistics of all channel gains, is aware instantaneously of a noisy version of the channel to the legitimate receiver. On the other hand, the legitimate receiver is aware instantaneously of its channel to the transmitter, whereas the eavesdropper instantaneously knows all channel gains. We evaluate an achievable rate using a Gaussian input without indexing an auxiliary random variable. A sufficient condition for beamforming to be optimal is provided. When the number of transmit antennas is large, beamforming also turns out to be optimal. In this case, the maximum achievable rate can be expressed in a simple closed form and scales with the logarithm of the number of transmit antennas. Furthermore, in the case when a noisy estimate of the eavesdropper’s channel is also available at the transmitter, we introduce the SNR difference and the SNR ratio criterions and derive the related optimal transmission strategies and the corresponding achievable rates.

  14. Tunable M-channel filter based on Thue-Morse heterostructures containing meta materials

    Directory of Open Access Journals (Sweden)

    H Pashaei Adl

    2015-01-01

    Full Text Available In this paper the tunable M-channel filters based on Thue-Morse heterostructures consisting of single -negative materials has been studied. The results showed that the number of resonance modes inside the zero- gap increases as the number of heterogenous interface, M, increases. The number of resonance modes inside the zero- gap is equal to that of heterogenous interface M, and it can be used as M channels filter. This result provides a feasible method to adjust the channel number of multiple-channel filters. When losses are involved, the results showed that the electric fields of the resonance modes decay largely with the increase of the number of heterogenous interface and damping factors. Besides, the relationship between the quality factor of multiple-channel filters and the number of heterogenous interface M is linear, and the quality factor of multiple-channel filters decreases with the increase of the damping factor. These results provide feasible methods to adjust the quality factor of multiple-channel filters

  15. Whole-body cryostimulation (cryotherapy) provides benefits for fatigue and functional status in multiple sclerosis patients. A case-control study.

    Science.gov (United States)

    Miller, E; Kostka, J; Włodarczyk, T; Dugué, B

    2016-12-01

    To study the effects of whole-body cryostimulation (WBC) on fatigue and functional status in multiple sclerosis (MS) patients with different levels of fatigue. Two groups of 24 MS patients with fatigue were studied. At the beginning of the study, the first group presented a Fatigue Severity Scale (FSS) score between 38 and 42 (low-fatigue (LF) group), and the second group had an FSS score between 48 and 52 (high-fatigue (HF) group). Both groups were matched for age and sex. All patients were exposed to 10.3-min session of WBC (one exposure per day at -110°C or lower). Functional status was assessed before and after the series of WBC exposures using the Rivermead Motor Assessment (RMA), the Multiple Sclerosis Impact Scale (MSIS-29), and the Expanded Disability Status Scale (EDSS). The RMA was estimated in three sections: gross function (RMA1), leg and trunk (RMA2), and arm (RMA3). MSIS-29 consists of two subscales assessing the physical (MSIS-29-PHYS) and psychological (MSIS-29-PSYCH) status. In both groups, the WBC sessions induced a significant improvement in the functional status and in the feeling of fatigue. However, the changes observed in HF patients were significantly greater than those observed in LF patients, especially in the MSIS-29-PHYS, MSIS-29-PSYCH, RMA1, and RMA3. The changes observed in the EDSS, RMA2, and FSS were similar in both groups. WBC appears to be effective in improving functional status and the feeling of fatigue in patients with MS and especially in those who are the most fatigued. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. Pain in patients with multiple sclerosis: a complex assessment including quantitative and qualitative measurements provides for a disease-related biopsychosocial pain model

    Directory of Open Access Journals (Sweden)

    Michalski D

    2011-08-01

    Full Text Available Dominik Michalski1,*, Stefanie Liebig1,*, Eva Thomae1,2, Andreas Hinz3, Florian Then Bergh1,21Department of Neurology, 2Translational Centre for Regenerative Medicine (TRM, 3Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany *These authors contributed equallyBackground: Pain of various causes is a common phenomenon in patients with Multiple Sclerosis (MS. A biopsychosocial perspective has proven a useful theoretical construct in other chronic pain conditions and was also started in MS. To support such an approach, we aimed to investigate pain in MS with special emphasis on separating quantitative and qualitative aspects, and its interrelation to behavioral and physical aspects.Materials and methods: Pain intensity (NRS and quality (SES were measured in 38 consecutive outpatients with MS (mean age, 42.0 ± 11.5 years, 82% women. Pain-related behavior (FSR, health care utilization, bodily complaints (GBB-24 and fatigue (WEIMuS were assessed by questionnaires, and MS-related neurological impairment by a standardized neurological examination (EDSS.Results: Mean pain intensity was 4.0 (range, 0–10 and mean EDSS 3.7 (range, 0–8 in the overall sample. Currently present pain was reported by 81.6% of all patients. Disease duration and EDSS did not differ between patients with and without pain and were not correlated to quality or intensity of pain. Patients with pain had significantly higher scores of musculoskeletal complaints, but equal scores of exhaustion, gastrointestinal and cardiovascular complaints. Pain intensity correlated only with physical aspects, whereas quality of pain was additionally associated with increased avoidance, resignation and cognitive fatigue.Conclusion: As in other conditions, pain in MS must be assessed in a multidimensional way. Further research should be devoted to adapt existing models to a MS-specific model of pain.Keywords: pain intensity, quality of pain, pain

  17. A Single Nucleotide Polymorphism (rs4236480 in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients

    Directory of Open Access Journals (Sweden)

    Anas Khaleel

    2015-01-01

    Full Text Available Nephrolithiasis is characterized by calcification of stones in the kidneys from an unknown cause. Animal models demonstrated the functional roles of the transient receptor potential vanilloid member 5 (TRPV5 gene in calcium renal reabsorption and hypercalciuria. Therefore, TRPV5 was suggested to be involved in calcium homeostasis. However, whether genetic polymorphisms of TRPV5 are associated with kidney stone multiplicity or recurrence is unclear. In this study, 365 Taiwanese kidney-stone patients were recruited. Both biochemical data and DNA samples were collected. Genotyping was performed by a TaqMan allelic discrimination assay. We found that a TRPV5 polymorphism (rs4236480 was observed to be associated with stone multiplicity of calcium nephrolithiasis, as the risk of stone multiplicity was higher in patients with the TT+CT genotype than in patients with the CC genotype (p=0.0271. In summary, despite the complexity of nephrolithiasis and the potential association of numerous calcium homeostatic absorption/reabsorption factors, TRPV5 plays an important role in the pathogenesis of calcium nephrolithiasis.

  18. Effect of Providing Multiple Micronutrients in Powder through Primary Healthcare on Anemia in Young Brazilian Children: A Multicentre Pragmatic Controlled Trial.

    Science.gov (United States)

    Cardoso, Marly A; Augusto, Rosangela A; Bortolini, Gisele A; Oliveira, Cristieli S M; Tietzman, Daniela C; Sequeira, Leopoldina A S; Hadler, Maria Claret C M; Peixoto, Maria do Rosario G; Muniz, Pascoal T; Vitolo, Márcia R; Lira, Pedro I C; Jaime, Patrícia C

    2016-01-01

    Multiple micronutrients in powder (MNP) are recommended by WHO to prevent anemia in young children. However, evidences for its effectiveness in different populations and improvements in other outcomes (e.g. linear growth and vitamin A deficiency) are scarce. A multicentre pragmatic controlled trial was carried out in primary health centres. At study baseline, a control group (CG) of children aged 10- to 14 months (n = 521) was recruited in the routine healthcare for assessing anemia, anthropometric and micronutrient status. At the same time, an intervention group (IG) of infants aged 6- to 8 months (n = 462) was recruited to receive MNP daily in complementary feeding over a period of 60 days. Both study groups were compared when the IG infants reached the age of the CG children at enrolment. In CG, the prevalence of anemia [hemoglobin (Hb) 8.3 mg/L), and vitamin A deficiency (VAD, serum retinol micronutrient status among young Brazilian children. Registro Brasileiro de Ensaios Clinicos RBR-5ktv6b.

  19. D-BLAST OFDM with Channel Estimation

    Directory of Open Access Journals (Sweden)

    Du Jianxuan

    2004-01-01

    Full Text Available Multiple-input and multiple-output (MIMO systems formed by multiple transmit and receive antennas can improve performance and increase capacity of wireless communication systems. Diagonal Bell Laboratories Layered Space-Time (D-BLAST structure offers a low-complexity solution for realizing the attractive capacity of MIMO systems. However, for broadband wireless communications, channel is frequency-selective and orthogonal frequency division multiplexing (OFDM has to be used with MIMO techniques to reduce system complexity. In this paper, we investigate D-BLAST for MIMO-OFDM systems. We develop a layerwise channel estimation algorithm which is robust to channel variation by exploiting the characteristic of the D-BLAST structure. Further improvement is made by subspace tracking to considerably reduce the error floor. Simulation results show that the layerwise estimators require 1 dB less signal-to-noise ratio (SNR than the traditional blockwise estimator for a word error rate (WER of when Doppler frequency is 40 Hz. Among the layerwise estimators, the subspace-tracking estimator provides a 0.8 dB gain for WER with 200 Hz Doppler frequency compared with the DFT-based estimator.

  20. Non-invasive imaging provides spatiotemporal information on disease progression and response to therapy in a murine model of multiple myeloma.

    Directory of Open Access Journals (Sweden)

    Simone S Riedel

    Full Text Available BACKGROUND: Multiple myeloma (MM is a B-cell malignancy, where malignant plasma cells clonally expand in the bone marrow of older people, causing significant morbidity and mortality. Typical clinical symptoms include increased serum calcium levels, renal insufficiency, anemia, and bone lesions. With standard therapies, MM remains incurable; therefore, the development of new drugs or immune cell-based therapies is desirable. To advance the goal of finding a more effective treatment for MM, we aimed to develop a reliable preclinical MM mouse model applying sensitive and reproducible methods for monitoring of tumor growth and metastasis in response to therapy. MATERIAL AND METHODS: A mouse model was created by intravenously injecting bone marrow-homing mouse myeloma cells (MOPC-315.BM that expressed luciferase into BALB/c wild type mice. The luciferase in the myeloma cells allowed in vivo tracking before and after melphalan treatment with bioluminescence imaging (BLI. Homing of MOPC-315.BM luciferase+ myeloma cells to specific tissues was examined by flow cytometry. Idiotype-specific myeloma protein serum levels were measured by ELISA. In vivo measurements were validated with histopathology. RESULTS: Strong bone marrow tropism and subsequent dissemination of MOPC-315.BM luciferase(+ cells in vivo closely mimicked the human disease. In vivo BLI and later histopathological analysis revealed that 12 days of melphalan treatment slowed tumor progression and reduced MM dissemination compared to untreated controls. MOPC-315.BM luciferase(+ cells expressed CXCR4 and high levels of CD44 and α4β1 in vitro which could explain the strong bone marrow tropism. The results showed that MOPC-315.BM cells dynamically regulated homing receptor expression and depended on interactions with surrounding cells. CONCLUSIONS: This study described a novel MM mouse model that facilitated convenient, reliable, and sensitive tracking of myeloma cells with whole body BLI in

  1. Effect of Providing Multiple Micronutrients in Powder through Primary Healthcare on Anemia in Young Brazilian Children: A Multicentre Pragmatic Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Marly A Cardoso

    Full Text Available Multiple micronutrients in powder (MNP are recommended by WHO to prevent anemia in young children. However, evidences for its effectiveness in different populations and improvements in other outcomes (e.g. linear growth and vitamin A deficiency are scarce.A multicentre pragmatic controlled trial was carried out in primary health centres. At study baseline, a control group (CG of children aged 10- to 14 months (n = 521 was recruited in the routine healthcare for assessing anemia, anthropometric and micronutrient status. At the same time, an intervention group (IG of infants aged 6- to 8 months (n = 462 was recruited to receive MNP daily in complementary feeding over a period of 60 days. Both study groups were compared when the IG infants reached the age of the CG children at enrolment.In CG, the prevalence of anemia [hemoglobin (Hb 8.3 mg/L, and vitamin A deficiency (VAD, serum retinol < 0.70μmol/L were 23.1%, 37.4%, and 17.4%, respectively. Four to six months after enrolment, when the IG participants had the same age of the controls at the time of testing, the prevalence of anemia, ID and VAD in IG were 14.3%, 30.1% and 7.9%, respectively. Adjusting for city, health centre, maternal education, and age, IG children had a lower likelihood of anemia and VAD [Prevalence Ratio (95% CI = 0.63 (0.45, 0.88 and 0.45 (0.29, 0.69, respectively] when compared with CG children. The adjusted mean distributions of Hb and length-for-age Z-scores improved by 2 SE in the IG compared to CG children.MNP effectively reduced anemia and improved growth and micronutrient status among young Brazilian children.Registro Brasileiro de Ensaios Clinicos RBR-5ktv6b.

  2. Ten-year review of groin laparoscopy in 1001 pediatric patients with clinical unilateral inguinal hernia: an improved technique with transhernia multiple-channel scope.

    Science.gov (United States)

    Saad, Saad; Mansson, Jonas; Saad, Adam; Goldfarb, Michael A

    2011-05-01

    The purpose of this 10-year review of data is to verify the effectiveness, safety, and appropriate age group for using a multichannel scope during inguinal herniorrhaphy in pediatric patients with clinical unilateral inguinal hernia to evaluate for contralateral patent processus vaginalis (CPPV). The data evaluated are age, sex, negative findings, positive findings, false positives, false negatives, recurrences, date of recurrence, and complications. Patients who clinically had bilateral hernias or were born prematurely were excluded. A 5-mm, 30° multichannel scope was used through the ipsilateral open hernia sac to explore the contralateral internal ring. A Fogarty catheter was used through one of the channels of the scope to probe the contralateral side in instances of questionable patent processus vaginalis. One thousand one patients were studied, and a total of 237 CPPVs (23%) were identified. The highest incidence of CPPV was found in those patients younger than 1 year (44%). Contralateral patent processus vaginalis was identified and ligated in 34% of patients younger than 2 years, 20% in patients 2 to 8 years old, and 17% of patients 9 to 18 years old. There were no false positives and 6 false negatives (0.6%) of the contralateral side. There were 3 (0.3%) recurrent inguinal hernias of the ipsilateral side and no complications. The use of a multichannel scope through the ipsilateral open hernia sac during inguinal herniorrhaphy in pediatric patients with clinical unilateral inguinal hernia to evaluate for CPPV proved to be effective, cost-effective, and safe. Our procedure eliminated any additional scars and the cost of trocars and permitted us to probe the contralateral internal ring. Unnecessary open exploration was spared in 56% of children younger than 1 year and proved to be useful in all pediatric patients up to the age of 18 years. Copyright © 2011 Elsevier Inc. All rights reserved.

  3. Free Probability based Capacity Calculation of Multiantenna Gaussian Fading Channels with Cochannel Interference

    CERN Document Server

    Chatzinotas, Symeon

    2010-01-01

    During the last decade, it has been well understood that communication over multiple antennas can increase linearly the multiplexing capacity gain and provide large spectral efficiency improvements. However, the majority of studies in this area were carried out ignoring cochannel interference. Only a small number of investigations have considered cochannel interference, but even therein simple channel models were employed, assuming identically distributed fading coefficients. In this paper, a generic model for a multi-antenna channel is presented incorporating four impairments, namely additive white Gaussian noise, flat fading, path loss and cochannel interference. Both point-to-point and multiple-access MIMO channels are considered, including the case of cooperating Base Station clusters. The asymptotic capacity limit of this channel is calculated based on an asymptotic free probability approach which exploits the additive and multiplicative free convolution in the R- and S-transform domain respectively, as ...

  4. User Partitioning for Less Overhead in MIMO Interference Channels

    CERN Document Server

    Peters, Steven W

    2010-01-01

    This paper presents a study on multiple-antenna interference channels, accounting for general overhead as a function of the number of users and antennas in the network. The model includes both perfect and imperfect channel state information based on channel estimation in the presence of noise. Three low complexity methods are proposed for reducing the impact of overhead in the sum network throughput by partitioning users into orthogonal groups. The first method allocates spectrum to the groups equally, creating an imbalance in the sum rate of each group. The second proposed method allocates spectrum unequally among the groups to provide rate fairness. Finally, geographic grouping is proposed for cases where some receivers do not observe significant interference from other transmitters. For each partitioning method, the optimal solution not only requires a brute force search over all possible partitions, but also requires full channel state information, thereby defeating the purpose of partitioning. We therefo...

  5. Finger Multiplication

    Science.gov (United States)

    Simanihuruk, Mudin

    2011-01-01

    Multiplication facts are difficult to teach. Therefore many researchers have put a great deal of effort into finding multiplication strategies. Sherin and Fuson (2005) provided a good survey paper on the multiplication strategies research area. Kolpas (2002), Rendtorff (1908), Dabell (2001), Musser (1966) and Markarian (2009) proposed the finger…

  6. Self-reported changes in quality of life among people with multiple sclerosis who have participated in treatments based on collaboration between conventional healthcare providers and CAM practitioners

    DEFF Research Database (Denmark)

    Bjerre, Liv; Henningsen, Inge Biehl; Skovgaard, Lasse

    2011-01-01

    . Materials and methods: A pre- and post-test evaluation design including an intervention group and a comparison group was employed in this study. 142 people with MS were analysed in the intervention group and 142 in the comparison group. Each person in the intervention group was treated with combined......Lwas found within the areas of emotional well-being and thinking/fatigue. Conclusion: The results indicate that collaboration between healthcare providers andCAMpractitioners can improve treatment outcomes regarding some of the psychological aspects of QoL over a period of 18 months for people with MS....

  7. Multiple descriptions for packetized predictive control

    DEFF Research Database (Denmark)

    Østergaard, Jan; Quevedo, Daniel

    2016-01-01

    In this paper, we propose to use multiple descriptions (MDs) to achieve a high degree of robustness towards random packet delays and erasures in networked control systems. In particular, we consider the scenario, where a data-rate limited channel is located between the controller and the plant...... input. This forward channel also introduces random delays and dropouts. The feedback channel from the plant output to the controller is assumed noiseless. We show how to design MDs for packetized predicted control (PPC) in order to enhance the robustness. In the proposed scheme, a quantized control...... be reliably reconstructed at the plant side. For the particular case of LTI plant models and i.i.d. channels, we show that the overall system forms a Markov jump linear system. We provide conditions for mean square stability and derive upper bounds on the operational bit rate of the quantizer to guarantee...

  8. Combined gene/cell therapies provide long-term and pervasive rescue of multiple pathological symptoms in a murine model of globoid cell leukodystrophy

    Science.gov (United States)

    Ricca, Alessandra; Rufo, Nicole; Ungari, Silvia; Morena, Francesco; Martino, Sabata; Kulik, Wilem; Alberizzi, Valeria; Bolino, Alessandra; Bianchi, Francesca; Del Carro, Ubaldo; Biffi, Alessandra; Gritti, Angela

    2015-01-01

    Globoid cell leukodystrophy (GLD) is a lysosomal storage disease caused by deficient activity of β-galactocerebrosidase (GALC). The infantile forms manifest with rapid and progressive central and peripheral demyelination, which represent a major hurdle for any treatment approach. We demonstrate here that neonatal lentiviral vector-mediated intracerebral gene therapy (IC GT) or transplantation of GALC-overexpressing neural stem cells (NSC) synergize with bone marrow transplant (BMT) providing dramatic extension of lifespan and global clinical–pathological rescue in a relevant GLD murine model. We show that timely and long-lasting delivery of functional GALC in affected tissues ensured by the exclusive complementary mode of action of the treatments underlies the outstanding benefit. In particular, the contribution of neural stem cell transplantation and IC GT during the early asymptomatic stage of the disease is instrumental to enhance long-term advantage upon BMT. We clarify the input of central nervous system, peripheral nervous system and periphery to the disease, and the relative contribution of treatments to the final therapeutic outcome, with important implications for treatment strategies to be tried in human patients. This study gives proof-of-concept of efficacy, tolerability and clinical relevance of the combined gene/cell therapies proposed here, which may constitute a feasible and effective therapeutic opportunity for children affected by GLD. PMID:25749991

  9. Uplink Channel Dependent Scheduling for Future Cellular Systems

    OpenAIRE

    Jersenius, Kristina

    2007-01-01

    One goal in the development of future cellular systems is to increase performance. Channel dependent scheduling can possibly contribute to a performance enhancement. It requires channel qualityinformation and uplink channel knowledge is often incomplete. This master thesis work compares channel dependent scheduling and channel independent scheduling for a Single Carrier Frequency Division Multiple Access-based uplink in time domain and time and frequencydomain assuming continuous channel qual...

  10. Case management takes a dynamic turn: progressive contact centers can incorporate adaptability, cross-sell and upsell capabilities, social media integration, gamification, and multiple channels

    National Research Council Canada - National Science Library

    Klie, Leonard

    2013-01-01

    ... collaboration for agents to bring them to a resolution. Fortunately, new developments in analytics, social media, integration, dynamic case management, and gamification enable today's customer care professionals to get a lot more out of case management than ever before. A CASE FOR INTEGRATION TMA Resources, a provider of software to help professional societies...

  11. A retrospective analysis of 3954 patients in phase 2/3 trials of bortezomib for the treatment of multiple myeloma: towards providing a benchmark for the cardiac safety profile of proteasome inhibition in multiple myeloma.

    Science.gov (United States)

    Laubach, Jacob P; Moslehi, Javid J; Francis, Sanjeev A; San Miguel, Jesús F; Sonneveld, Pieter; Orlowski, Robert Z; Moreau, Philippe; Rosiñol, Laura; Faber, Edward A; Voorhees, Peter; Mateos, Maria-Victoria; Marquez, Loreta; Feng, Huaibao; Desai, Avinash; van de Velde, Helgi; Elliott, Jennifer; Shi, Hongliang; Dow, Edward; Jobanputra, Nishith; Esseltine, Dixie-Lee; Niculescu, Liviu; Anderson, Kenneth C; Lonial, Sagar; Richardson, Paul G

    2017-08-01

    This retrospective analysis aimed to establish the overall cardiac safety profile of bortezomib using patient-level data from one phase 2 and seven phase 3 studies in previously untreated and relapsed/refractory multiple myeloma (MM). Seven clinically relevant primary [congestive heart failure (CHF), arrhythmias, ischaemic heart disease (IHD), cardiac death] and secondary (hypertension, dyspnoea, oedema) cardiac endpoints were defined based on MedDRA v16.0 preferred terms. 2509 bortezomib-treated patients and 1445 patients in non-bortezomib-based control arms were included. The incidence of grade ≥3 CHF was 1·3-4·0% in studies in relapsed/refractory MM and 1·2-4·7% in previously untreated MM (2·0-7·6% all grades), with no significant differences between bortezomib- and non-bortezomib-based arms in comparative studies. Incidences of arrhythmias (1·3-5·9% grade ≥2; 0·6-4·1% grade ≥3), IHD (1·2-2·9% all grades; 0·4-2·7% grade ≥3) and cardiac death (0-1·4%) were low, with no differences between bortezomib-based and non-bortezomib-based arms. Higher rates of oedema (mostly grade 1/2) were seen in bortezomib-based versus non-bortezomib-based arms in one study and a pooled transplant study analysis. Logistic regression analyses of comparative studies showed no impact on cardiac risk with bortezomib-based versus non-bortezomib-based treatment. Bortezomib-based treatment was associated with low incidences of cardiac events. © 2017 John Wiley & Sons Ltd.

  12. MARKETING CHANNELS

    Directory of Open Access Journals (Sweden)

    Ljiljana Stošić Mihajlović

    2014-07-01

    Full Text Available Marketing channel is a set of entities and institutions, completion of distribution and marketing activities, attend the efficient and effective networking of producers and consumers. Marketing channels include the total flows of goods, money and information taking place between the institutions in the system of marketing, establishing a connection between them. The functions of the exchange, the physical supply and service activities, inherent in the system of marketing and trade. They represent paths which products and services are moving after the production, which will ultimately end up buying and eating by the user.

  13. Changes in cerebral blood flow during olfactory stimulation in patients with multiple chemical sensitivity: a multi-channel near-infrared spectroscopic study.

    Directory of Open Access Journals (Sweden)

    Kenichi Azuma

    Full Text Available Multiple chemical sensitivity (MCS is characterized by somatic distress upon exposure to odors. Patients with MCS process odors differently from controls. This odor-processing may be associated with activation in the prefrontal area connecting to the anterior cingulate cortex, which has been suggested as an area of odorant-related activation in MCS patients. In this study, activation was defined as a significant increase in regional cerebral blood flow (rCBF because of odorant stimulation. Using the well-designed card-type olfactory test kit, changes in rCBF in the prefrontal cortex (PFC were investigated after olfactory stimulation with several different odorants. Near-infrared spectroscopic (NIRS imaging was performed in 12 MCS patients and 11 controls. The olfactory stimulation test was continuously repeated 10 times. The study also included subjective assessment of physical and psychological status and the perception of irritating and hedonic odors. Significant changes in rCBF were observed in the PFC of MCS patients on both the right and left sides, as distinct from the center of the PFC, compared with controls. MCS patients adequately distinguished the non-odorant in 10 odor repetitions during the early stage of the olfactory stimulation test, but not in the late stage. In comparison to controls, autonomic perception and negative affectivity were poorer in MCS patients. These results suggest that prefrontal information processing associated with odor-processing neuronal circuits and memory and cognition processes from past experience of chemical exposure play significant roles in the pathology of this disorder.

  14. Experimental demonstration of block interleaved frequency division multiple access for bidirectional visible light communications

    Science.gov (United States)

    Lin, Bangjiang; Yang, Hui; Ye, Weiping; Tang, Xuan; Ghassemlooy, Zabih

    2017-01-01

    We propose a power efficient multiple access scheme for visible light communications (VLC) based on the block interleaved frequency division multiple access (B-IFDMA) which provides large frequency-diversity, flexible bandwidth allocation, low complexity of channel equalization, and user separation. Bidirectional B-IFDMA VLC transmission is experimentally demonstrated to verify its feasibility. The impact of the number of subcarriers per block on the transmission performance under wireless optical channel is investigated.

  15. G-Channel Restoration for RWB CFA with Double-Exposed W Channel.

    Science.gov (United States)

    Park, Chulhee; Song, Ki Sun; Kang, Moon Gi

    2017-02-05

    In this paper, we propose a green (G)-channel restoration for a red-white-blue (RWB) color filter array (CFA) image sensor using the dual sampling technique. By using white (W) pixels instead of G pixels, the RWB CFA provides high-sensitivity imaging and an improved signal-to-noise ratio compared to the Bayer CFA. However, owing to this high sensitivity, the W pixel values become rapidly over-saturated before the red-blue (RB) pixel values reach the appropriate levels. Because the missing G color information included in the W channel cannot be restored with a saturated W, multiple captures with dual sampling are necessary to solve this early W-pixel saturation problem. Each W pixel has a different exposure time when compared to those of the R and B pixels, because the W pixels are double-exposed. Therefore, a RWB-to-RGB color conversion method is required in order to restore the G color information, using a double-exposed W channel. The proposed G-channel restoration algorithm restores G color information from the W channel by considering the energy difference caused by the different exposure times. Using the proposed method, the RGB full-color image can be obtained while maintaining the high-sensitivity characteristic of the W pixels.

  16. MiR-17-5p impairs trafficking of H-ERG K+ channel protein by targeting multiple er stress-related chaperones during chronic oxidative stress.

    Directory of Open Access Journals (Sweden)

    Qi Wang

    Full Text Available BACKGROUND: To investigate if microRNAs (miRNAs play a role in regulating h-ERG trafficking in the setting of chronic oxidative stress as a common deleterious factor for many cardiac disorders. METHODS: We treated neonatal rat ventricular myocytes and HEK293 cells with stable expression of h-ERG with H2O2 for 12 h and 48 h. Expression of miR-17-5p seed miRNAs was quantified by real-time RT-PCR. Protein levels of chaperones and h-ERG trafficking were measured by Western blot analysis. Luciferase reporter gene assay was used to study miRNA and target interactions. Whole-cell patch-clamp techniques were employed to record h-ERG K(+ current. RESULTS: H-ERG trafficking was impaired by H2O2 after 48 h treatment, accompanied by reciprocal changes of expression between miR-17-5p seed miRNAs and several chaperones (Hsp70, Hsc70, CANX, and Golga2, with the former upregulated and the latter downregulated. We established these chaperones as targets for miR-17-5p. Application miR-17-5p inhibitor rescued H2O2-induced impairment of h-ERG trafficking. Upregulation of endogenous by H2O2 or forced miR-17-5p expression either reduced h-ERG current. Sequestration of AP1 by its decoy molecule eliminated the upregulation of miR-17-5p, and ameliorated impairment of h-ERG trafficking. CONCLUSIONS: Collectively, deregulation of the miR-17-5p seed family miRNAs can cause severe impairment of h-ERG trafficking through targeting multiple ER stress-related chaperones, and activation of AP1 likely accounts for the deleterious upregulation of these miRNAs, in the setting of prolonged duration of oxidative stress. These findings revealed the role of miRNAs in h-ERG trafficking, which may contribute to the cardiac electrical disturbances associated with oxidative stress.

  17. Minimum Interference Channel Assignment Algorithm for Multicast in a Wireless Mesh Network.

    Science.gov (United States)

    Choi, Sangil; Park, Jong Hyuk

    2016-12-02

    Wireless mesh networks (WMNs) have been considered as one of the key technologies for the configuration of wireless machines since they emerged. In a WMN, wireless routers provide multi-hop wireless connectivity between hosts in the network and also allow them to access the Internet via gateway devices. Wireless routers are typically equipped with multiple radios operating on different channels to increase network throughput. Multicast is a form of communication that delivers data from a source to a set of destinations simultaneously. It is used in a number of applications, such as distributed games, distance education, and video conferencing. In this study, we address a channel assignment problem for multicast in multi-radio multi-channel WMNs. In a multi-radio multi-channel WMN, two nearby nodes will interfere with each other and cause a throughput decrease when they transmit on the same channel. Thus, an important goal for multicast channel assignment is to reduce the interference among networked devices. We have developed a minimum interference channel assignment (MICA) algorithm for multicast that accurately models the interference relationship between pairs of multicast tree nodes using the concept of the interference factor and assigns channels to tree nodes to minimize interference within the multicast tree. Simulation results show that MICA achieves higher throughput and lower end-to-end packet delay compared with an existing channel assignment algorithm named multi-channel multicast (MCM). In addition, MICA achieves much lower throughput variation among the destination nodes than MCM.

  18. Sum-Rate Enhancement in Multiuser MIMO Decode-and-Forward Relay Broadcasting Channel with Energy Harvesting Relays

    KAUST Repository

    Benkhelifa, Fatma

    2016-09-20

    In this paper, we consider a multiuser multipleinput multiple-output (MIMO) decode-and-forward (DF) relay broadcasting channel (BC) with single source, multiple energy harvesting (EH) relays and multiple destinations. All the nodes are equipped with multiple antennas. The EH and information decoding (ID) tasks at the relays and destinations are separated over the time, which is termed as the time switching (TS) scheme. As optimal solutions for the sum-rate maximization problems of BC channels and the MIMO interference channels are hard to obtain, the end-to-end sum rate maximization problem of a multiuser MIMO DF relay BC channel is even harder. In this paper, we propose to tackle a simplified problem where we employ the block diagonalization (BD) procedure at the source, and we mitigate the interference between the relaydestination channels using an algorithm similar to the BD method. In order to show the relevance of our low complex proposed solution, we compare it to the minimum mean-square error (MMSE) solution that was shown in the literature to be equivalent to the solution of the sum-rate maximization in MIMO broadcasting interfering channels. We also investigate the time division multiple access (TDMA) solution which separates all the information transmissions from the source to the relays and from the relays to the destinations over time. We provide numerical results to show the relevance of our proposed solution, in comparison with the no co-channel interference (CCI) case, the TDMA based solution and the MMSE based solution.

  19. An information-guided channel-hopping scheme for block-fading channels with estimation errors

    KAUST Repository

    Yang, Yuli

    2010-12-01

    Information-guided channel-hopping technique employing multiple transmit antennas was previously proposed for supporting high data rate transmission over fading channels. This scheme achieves higher data rates than some mature schemes, such as the well-known cyclic transmit antenna selection and space-time block coding, by exploiting the independence character of multiple channels, which effectively results in having an additional information transmitting channel. Moreover, maximum likelihood decoding may be performed by simply decoupling the signals conveyed by the different mapping methods. In this paper, we investigate the achievable spectral efficiency of this scheme in the case of having channel estimation errors, with optimum pilot overhead for minimum meansquare error channel estimation, when transmitting over blockfading channels. Our numerical results further substantiate the robustness of the presented scheme, even with imperfect channel state information. ©2010 IEEE.

  20. Channel Characterization and Robust Tracking for Diversity Reception over Time-Variant Off-Body Wireless Communication Channels

    Science.gov (United States)

    Van Torre, Patrick; Vallozzi, Luigi; Rogier, Hendrik; Moeneclaey, Marc; Verhaevert, Jo

    2010-12-01

    In the 2.45 GHz band, indoor wireless off-body data communication by a moving person can be problematic due to time-variant signal fading and the consequent variation in channel parameters. Off-body communication specifically suffers from the combined effects of fading, shadowing, and path loss due to time-variant multipath propagation in combination with shadowing by the human body. Measurements are performed to analyze the autocorrelation, coherence time, and power spectral density for a person equipped with a wearable receive system moving at different speeds for different configurations and antenna positions. Diversity reception with multiple textile antennas integrated in the clothing provides a means of improving the reliability of the link. For the dynamic channel estimation, a scheme using hard decision feedback after MRC with adaptive low-pass filtering is demonstrated to be successful in providing robust data detection for long data bursts, in the presence of dramatic channel variation.

  1. 3D Massive MIMO Systems: Channel Modeling and Performance Analysis

    KAUST Repository

    Nadeem, Qurrat-Ul-Ain

    2015-03-01

    Multiple-input-multiple-output (MIMO) systems of current LTE releases are capable of adaptation in the azimuth only. More recently, the trend is to enhance the system performance by exploiting the channel\\'s degrees of freedom in the elevation through the dynamic adaptation of the vertical antenna beam pattern. This necessitates the derivation and characterization of three-dimensional (3D) channels. Over the years, channel models have evolved to address the challenges of wireless communication technologies. In parallel to theoretical studies on channel modeling, many standardized channel models like COST-based models, 3GPP SCM, WINNER, ITU have emerged that act as references for industries and telecommunication companies to assess system-level and link-level performances of advanced signal processing techniques over real-like channels. Given the existing channels are only two dimensional (2D) in nature; a large effort in channel modeling is needed to study the impact of the channel component in the elevation direction. The first part of this work sheds light on the current 3GPP activity around 3D channel modeling and beamforming, an aspect that to our knowledge has not been extensively covered by a research publication. The standardized MIMO channel model is presented, that incorporates both the propagation effects of the environment and the radio effects of the antennas. In order to facilitate future studies on the use of 3D beamforming, the main features of the proposed 3D channel model are discussed. A brief overview of the future 3GPP 3D channel model being outlined for the next generation of wireless networks is also provided. In the subsequent part of this work, we present an information-theoretic channel model for MIMO systems that supports the elevation dimension. The model is based on the principle of maximum entropy, which enables us to determine the distribution of the channel matrix consistent with the prior information on the angles of departure and

  2. Analyte distribution at channel intersections of electro-fluid-dynamic devices.

    Science.gov (United States)

    Liu, Chang; Luo, Yong; Fang, Ning; Chen, David D Y

    2011-02-15

    Mass conservation is the guiding principle for analyte distribution at channel intersections of microfluidic devices, where analyte migration is mainly driven by an applied electric field, and in electro-fluid-dynamic (EFD) devices, where multiple fields and pressures can be applied simultaneously on the same channel network. This paper introduces another type of conservation, the conservation of effective volumetric flow rate, at channel intersections when the conductivity of the solution in the intersecting channels is maintained constant. This conservation principle provides an additional criterion needed to describe analyte migration in channels connecting to a common intersection and to predict how analyte is distributed into individual channels in the channel network of EFD devices, when multiple voltages and pressures are applied. The theoretical bases of effective volumetric flow rate balance are discussed, and the potential use of this principle in conjunction with the principle of mass conservation to predict the migration behavior of analytes is demonstrated. Junctions of different geometry in EFD devices are used to demonstrate the validity of these equations, and the measured velocities and numbers of microbeads in each channel agree with the predicted values.

  3. Perceived quality of channel zapping

    NARCIS (Netherlands)

    Kooij, R.E.; Ahmed, K.; Brunnström, K.

    2006-01-01

    The end user experience of service quality is critical to the success of a service provider's IPTV deployment program. A key element involved in validating IPTV quality of experience (QoE) is how quickly and reliably users can change TV channels, often referred to as channel zapping. Currently there

  4. The Orange Juice Distribution Channels

    African Journals Online (AJOL)

    is to provide a general overview about the agents in the European marketing channels of the FCOJ, focusing on the final juice consumers, retailing, food service and the beverage industry. The framework for this part is build up of the marketing channel concepts and functions (Stern et al., 1996; Berman,. 1996; Rosembloom ...

  5. Medicare Provider Data - Hospice Providers

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Hospice Utilization and Payment Public Use File provides information on services provided to Medicare beneficiaries by hospice providers. The Hospice PUF...

  6. The role of cold carriers and the multiple-carrier process of Si-H bond dissociation for hot-carrier degradation in n- and p-channel LDMOS devices

    Science.gov (United States)

    Sharma, Prateek; Tyaginov, Stanislav; Jech, Markus; Wimmer, Yannick; Rudolf, Florian; Enichlmair, Hubert; Park, Jong-Mun; Ceric, Hajdin; Grasser, Tibor

    2016-01-01

    We apply our hot-carrier degradation (HCD) model, which uses the information about the carrier energy distribution, to represent HCD data measured in n- and p-channel LDMOS transistors. In the first version of our model we use the spherical harmonics expansion approach to solve the Boltzmann transport equation (BTE), while in the second version we employ the drift-diffusion scheme. In the latter case the carrier energy distribution function is approximated by an analytic expression with parameters found using the drift-diffusion scheme. The model, which has already been verified with nLDMOS transistors, is used to represent the carrier distribution functions, interface state density profiles, and changes of the drain currents vs. stress time in pLDMOS transistor. Particular attention is paid to study the role of the cold fraction of the carrier ensemble. We check the validity of the model by neglecting the effect of cold carriers in HCD modeling in the case of nLDMOS devices stressed at high voltages. In our model, cold carriers are represented by the corresponding term in the analytic formula for the carrier distribution function as well as by the multiple-carrier process of the Si-H bond dissociation. We show that even in high-voltage devices stressed at high drain voltages the thermalized carriers still have a substantial contribution to HCD.

  7. Quantitative analysis of oyster larval proteome provides new insights into the effects of multiple climate change stressors, supplement to: Dineshram, R; Chandramouli, K; Ko, W K Ginger; Zhang, Huoming; Qian, Pei Yuan; Ravasi, Timothy; Thiyagarajan, Vengatesen (2016): Quantitative analysis of oyster larval proteome provides new insights into the effects of multiple climate change stressors. Global Change Biology, 22(6), 2054-2068

    KAUST Repository

    Dineshram, R

    2016-01-01

    The metamorphosis of planktonic larvae of the Pacific oyster (Crassostrea gigas) underpins their complex life-history strategy by switching on the molecular machinery required for sessile life and building calcite shells. Metamorphosis becomes a survival bottleneck, which will be pressured by different anthropogenically induced climate change-related variables. Therefore, it is important to understand how metamorphosing larvae interact with emerging climate change stressors. To predict how larvae might be affected in a future ocean, we examined changes in the proteome of metamorphosing larvae under multiple stressors: decreased pH (pH 7.4), increased temperature (30 °C), and reduced salinity (15 psu). Quantitative protein expression profiling using iTRAQ-LC-MS/MS identified more than 1300 proteins. Decreased pH had a negative effect on metamorphosis by down-regulating several proteins involved in energy production, metabolism, and protein synthesis. However, warming switched on these down-regulated pathways at pH 7.4. Under multiple stressors, cell signaling, energy production, growth, and developmental pathways were up-regulated, although metamorphosis was still reduced. Despite the lack of lethal effects, significant physiological responses to both individual and interacting climate change related stressors were observed at proteome level. The metamorphosing larvae of the C. gigas population in the Yellow Sea appear to have adequate phenotypic plasticity at the proteome level to survive in future coastal oceans, but with developmental and physiological costs.

  8. Multi-Channel Retailing and Customer Satisfaction: Implications for E-CRM

    OpenAIRE

    Patricia T. Warrington; Elizabeth Gangstad; Richard Feinberg; Ko de Ruyter

    2007-01-01

    Multi-channel retailers that utilize an e-CRM approach stand to benefit in multiple arenas by providing targeted customer service as well as gaining operational and competitive advantages. To that end, it is inherent that multi-channel retailers better understand how satisfaction—a necessary condition for building customer loyalty—influences consumers’ decisions to shop in one retail channel or another. The purpose of this study was to examine the influence of shopping experience on cus...

  9. On Shor's Channel Extension and Constrained Channels

    Science.gov (United States)

    Holevo, A. S.; Shirokov, M. E.

    Several equivalent formulations of the additivity conjecture for constrained channels, which formally is substantially stronger than the unconstrained additivity, are given. To this end a characteristic property of the optimal ensemble for such a channel is derived, generalizing the maximal distance property. It is shown that the additivity conjecture for constrained channels holds true for certain nontrivial classes of channels. After giving an algebraic formulation for Shor's channel extension, its main asymptotic property is proved. It is then used to show that additivity for two constrained channels can be reduced to the same problem for unconstrained channels, and hence, ``global'' additivity for channels with arbitrary constraints is equivalent to additivity without constraints.

  10. Low-Complexity Iterative Receiver for Space-Time Coded Signals over Frequency Selective Channels

    Directory of Open Access Journals (Sweden)

    Mohamed Siala

    2002-05-01

    Full Text Available We propose a low-complexity turbo-detector scheme for frequency selective multiple-input multiple-output channels. The detection part of the receiver is based on a List-type MAP equalizer which is a state-reduction algorithm of the MAP algorithm using per-survivor technique. This alternative achieves a good tradeoff between performance and complexity provided a small amount of the channel is neglected. In order to induce the good performance of this equalizer, we propose to use a whitened matched filter (WMF which leads to a white-noise “minimum phase” channel model. Simulation results show that the use of the WMF yields significant improvement, particularly over severe channels. Thanks to the iterative turbo processing (detection and decoding are iterated several times, the performance loss due to the use of the suboptimum List-type equalizer is recovered.

  11. A Perspective on the MIMO Wiretap Channel

    KAUST Repository

    Oggier, Frederique

    2015-10-01

    A wiretap channel is a communication channel between a transmitter Alice and a legitimate receiver Bob, in the presence of an eavesdropper Eve. The goal of communication is to achieve reliability between Alice and Bob, but also confidentiality despite Eve’s presence. Wiretap channels are declined in all kinds of flavors, depending on the underlying channels used by the three players: discrete memoryless channels, additive Gaussian noise channels, or fading channels, to name a few. In this survey, we focus on the case where the three players use multiple-antenna channels with Gaussian noise to communicate. After summarizing known results for multiple-input–multiple-output (MIMO) channels, both in terms of achievable reliable data rate (capacity) and code design, we introduce the MIMO wiretap channel. We then state the MIMO wiretap capacity, summarize the idea of the proof(s) behind this result, and comment on the insights given by the proofs on the physical meaning of the secrecy capacity. We finally discuss design criteria for MIMO wiretap codes.

  12. Human Slack Potassium Channel Mutations Increase Positive Cooperativity between Individual Channels

    Directory of Open Access Journals (Sweden)

    Grace E. Kim

    2014-12-01

    Full Text Available Disease-causing mutations in ion channels generally alter intrinsic gating properties such as activation, inactivation, and voltage dependence. We examined nine different mutations of the KCNT1 (Slack Na+-activated K+ channel that give rise to three distinct forms of epilepsy. All produced many-fold increases in current amplitude compared to the wild-type channel. This could not be accounted for by increases in the intrinsic open probability of individual channels. Rather, greatly increased opening was a consequence of cooperative interactions between multiple channels in a patch. The degree of cooperative gating was much greater for all of the mutant channels than for the wild-type channel, and could explain increases in current even in a mutant with reduced unitary conductance. We also found that the same mutation gave rise to different forms of epilepsy in different individuals. Our findings indicate that a major consequence of these mutations is to alter channel-channel interactions.

  13. Logical Link Control and Channel Scheduling for Multichannel Underwater Sensor Networks

    Directory of Open Access Journals (Sweden)

    Jun Li

    2012-08-01

    Full Text Available With recent developments in terrestrial wireless networks and advances in acoustic communications, multichannel technologies have been proposed to be used in underwater networks to increase data transmission rate over bandwidth-limited underwater channels. Due to high bit error rates in underwater networks, an efficient error control technique is critical in the logical link control (LLC sublayer to establish reliable data communications over intrinsically unreliable underwater channels. In this paper, we propose a novel protocol stack architecture featuring cross-layer design of LLC sublayer and more efficient packetto- channel scheduling for multichannel underwater sensor networks. In the proposed stack architecture, a selective-repeat automatic repeat request (SR-ARQ based error control protocol is combined with a dynamic channel scheduling policy at the LLC sublayer. The dynamic channel scheduling policy uses the channel state information provided via cross-layer design. It is demonstrated that the proposed protocol stack architecture leads to more efficient transmission of multiple packets over parallel channels. Simulation studies are conducted to evaluate the packet delay performance of the proposed cross-layer protocol stack architecture with two different scheduling policies: the proposed dynamic channel scheduling and a static channel scheduling. Simulation results show that the dynamic channel scheduling used in the cross-layer protocol stack outperforms the static channel scheduling. It is observed that, when the dynamic channel scheduling is used, the number of parallel channels has only an insignificant impact on the average packet delay. This confirms that underwater sensor networks will benefit from the use of multichannel communications.

  14. VFAT2 A front-end system on chip providing fast trigger information, digitized data storage and formatting for the charge sensitive readout of multi-channel silicon and gas particle detectors

    CERN Document Server

    Aspell, P; Chalmet, P; Kaplon, J; Kloukinas, K; Mugnier, H; Snoeys, W

    2007-01-01

    The architecture, key design parameters and results for a highly integrated front-end readout system fabricated as a single ASIC are presented. The chip (VFAT2) comprises complex analog and digital functions traditionally designed as separate components. VFAT2 contains very low noise 128 channel front-end amplification with programmable internal calibration, intelligent “fast OR” trigger building outputs, digital data tagging and storage, data formatting and data packet transmission with error protection. VFAT2 is designed to work in the demanding radiation environments posed by modern H.E.P. experiments and in particular the TOTEM experiment of the LHC. Measured results are presented demonstrating full functionality and excellent analog performance despite intensive digital activity on the same piece of silicon.

  15. VFAT2 A front-end "system on chip" providing fast trigger information and digitized data storage for the charge sensitive readout of multi-channel silicon and gas particle detectors

    CERN Document Server

    Aspell, P; Chalmet, P; Kaplon, J; Kloukinas, K; Mugnier, H; Snoeys, W; PH-EP

    2009-01-01

    The architecture, key design parameters and results for a highly integrated front-end readout system fabricated as a single ASIC are presented. The chip (VFAT2) comprises complex analog and digital functions traditionally designed as separate components. VFAT2 contains very low noise 128 channel front-end amplification with programmable internal calibration, intelligent "fast OR" trigger building outputs, digital data tagging and storage, data formatting and data packet transmission with error protection. VFAT2 is designed to work in the demanding radiation environments posed by modern high energy physics experiments, in particular the Large Hadron Collider at CERN. Measured results are presented demonstrating full functionality and excellent analog performance despite intensive digital activity on the same piece of silicon.

  16. Multi-channel medical imaging system

    Energy Technology Data Exchange (ETDEWEB)

    Frangioni, John V

    2013-12-31

    A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in the subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest.

  17. Multi-channel medical imaging system

    Energy Technology Data Exchange (ETDEWEB)

    Frangioni, John V.

    2016-05-03

    A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest.

  18. Dual axial channel heat pipe

    Energy Technology Data Exchange (ETDEWEB)

    Alario, J.P.; Haslett, R.A.; Kosson, R.L.

    1984-09-11

    A heat pipe comprising an elongated sealed metallic envelope having at least a pair of longitudinal channels extending along the length thereof. One of the channels is for the circulation of the vapor phase of the working medium in operation and the other for the liquid phase and capillary means are provided to furnish fluid communication therebetween. Dedicated vapor and liquid channels result in low viscous pressure drops, the capillary communication means and circumferential grooving in the vapor channel provide high capillary pressure differences, and circumferential grooving is provided to furnish the high evaporation and condensation film coefficients required. To support higher heat fluxes, wicking can be used to augment the capillary flow from the liquid channel. To support higher evaporator heat flux without the need for wicking means, the heat pipe can be provided with more than one liquid channel, each communicating with the vapor channel by capillary means. The heat pipe can be provided with an integral fin or equivalent means for rejection of heat by radiation to ambient or for attachment to a source of heat in the evaporator region thereof.

  19. K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.

    Science.gov (United States)

    Dong, Yin Yao; Pike, Ashley C W; Mackenzie, Alexandra; McClenaghan, Conor; Aryal, Prafulla; Dong, Liang; Quigley, Andrew; Grieben, Mariana; Goubin, Solenne; Mukhopadhyay, Shubhashish; Ruda, Gian Filippo; Clausen, Michael V; Cao, Lishuang; Brennan, Paul E; Burgess-Brown, Nicola A; Sansom, Mark S P; Tucker, Stephen J; Carpenter, Elisabeth P

    2015-03-13

    TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple stimuli such as stretch, fatty acids, and pH and by several drugs. However, the mechanisms that control channel gating are unclear. Here we present crystal structures of the human TREK-2 channel (up to 3.4 angstrom resolution) in two conformations and in complex with norfluoxetine, the active metabolite of fluoxetine (Prozac) and a state-dependent blocker of TREK channels. Norfluoxetine binds within intramembrane fenestrations found in only one of these two conformations. Channel activation by arachidonic acid and mechanical stretch involves conversion between these states through movement of the pore-lining helices. These results provide an explanation for TREK channel mechanosensitivity, regulation by diverse stimuli, and possible off-target effects of the serotonin reuptake inhibitor Prozac. Copyright © 2015, American Association for the Advancement of Science.

  20. Mutual Information of IID Complex Gaussian Signals on Block Rayleigh-faded Channels

    CERN Document Server

    Rusek, Fredrik; Jindal, Nihar

    2010-01-01

    We present a method to compute, quickly and efficiently, the mutual information achieved by an IID (independent identically distributed) complex Gaussian input on a block Rayleigh-faded channel without side information at the receiver. The method accommodates both scalar and MIMO (multiple-input multiple-output) settings. Operationally, the mutual information thus computed represents the highest spectral efficiency that can be attained using standard Gaussian codebooks. Examples are provided that illustrate the loss in spectral efficiency caused by fast fading and how that loss is amplified by the use of multiple transmit antennas. These examples are further enriched by comparisons with the channel capacity under perfect channel-state information at the receiver, and with the spectral efficiency attained by pilot-based transmission.

  1. Impact of Clustering in Indoor MIMO Propagation Using a Hybrid Channel Model

    Directory of Open Access Journals (Sweden)

    Tang Zhongwei

    2005-01-01

    Full Text Available The clustering of propagating signals in indoor environments can influence the performance of multiple-input multiple-output (MIMO systems that employ multiple-element antennas at the transmitter and receiver. In order to clarify the effect of clustering propagation on the performance of indoor MIMO systems, we propose a simple and efficient indoor MIMO channel model. The proposed model, which is validated with on-site measurements, combines the statistical characteristics of signal clusters with deterministic ray tracing approach. Using the proposed model, the effect of signal clusters and the presence of the line-of-sight component in indoor Ricean channels are studied. Simulation results on channel efficiency and the angular sensitivity for different antenna array topologies inside a specified indoor scenario are also provided. Our investigations confirm that the clustering of signals significantly affects the spatial correlation, and hence, the achievable indoor MIMO capacity.

  2. Additive Classical Capacity of Quantum Channels Assisted by Noisy Entanglement

    Science.gov (United States)

    Zhuang, Quntao; Zhu, Elton Yechao; Shor, Peter W.

    2017-05-01

    We give a capacity formula for the classical information transmission over a noisy quantum channel, with separable encoding by the sender and limited resources provided by the receiver's preshared ancilla. Instead of a pure state, we consider the signal-ancilla pair in a mixed state, purified by a "witness." Thus, the signal-witness correlation limits the resource available from the signal-ancilla correlation. Our formula characterizes the utility of different forms of resources, including noisy or limited entanglement assistance, for classical communication. With separable encoding, the sender's signals across multiple channel uses are still allowed to be entangled, yet our capacity formula is additive. In particular, for generalized covariant channels, our capacity formula has a simple closed form. Moreover, our additive capacity formula upper bounds the general coherent attack's information gain in various two-way quantum key distribution protocols. For Gaussian protocols, the additivity of the formula indicates that the collective Gaussian attack is the most powerful.

  3. Bit-padding information guided channel hopping

    KAUST Repository

    Yang, Yuli

    2011-02-01

    In the context of multiple-input multiple-output (MIMO) communications, we propose a bit-padding information guided channel hopping (BP-IGCH) scheme which breaks the limitation that the number of transmit antennas has to be a power of two based on the IGCH concept. The proposed scheme prescribes different bit-lengths to be mapped onto the indices of the transmit antennas and then uses padding technique to avoid error propagation. Numerical results and comparisons, on both the capacity and the bit error rate performances, are provided and show the advantage of the proposed scheme. The BP-IGCH scheme not only offers lower complexity to realize the design flexibility, but also achieves better performance. © 2011 IEEE.

  4. Convex decomposition of dimension-altering quantum channels

    Science.gov (United States)

    Wang, Dong-Sheng

    2016-11-01

    Quantum channels, which are completely positive and trace preserving mappings, can alter the dimension of a system, e.g. a quantum channel from a qubit to a qutrit. We study the convex set properties of dimension-altering quantum channels, and particularly the channel decomposition problem in terms of convex sum of extreme channels. We provide various quantum circuit representations of extreme and generalized extreme channels, which can be employed in an optimization to approximately decompose an arbitrary channel. Numerical simulations of low-dimensional channels are performed to demonstrate our channel decomposition scheme.

  5. Channel Modelling for Multiprobe Over-the-Air MIMO Testing

    OpenAIRE

    Kyösti, Pekka; Jämsä, Tommi; Nuutinen, Jukka-Pekka

    2012-01-01

    This paper discusses over-the-air (OTA) test setup for multiple-input-multiple-output (MIMO) capable terminals with emphasis on channel modelling. The setup is composed of a fading emulator, an anechoic chamber, and multiple probes. Creation of a propagation environment inside an anechoic chamber requires unconventional radio channel modelling, namely, a specific mapping of the original models onto the probe antennas. We introduce two novel methods to generate fading emulator channel coeff...

  6. Using Social Media as a Marketing Channel : how relevance, realness, and remarkableness influence interactivity and engagement

    NARCIS (Netherlands)

    A. Boer, de

    2010-01-01

    This research explored a potential working framework for using social media as a marketing channel. Based on an extensive literature review and a multiple case study, important factors for using social media have been identified. Companies should provide relevant information, show signs of real

  7. Designing Effective Persuasive Systems Utilizing the Power of Entanglement: Communication Channel, Strategy & Affect

    Science.gov (United States)

    Li, Haiqing

    2010-01-01

    With rapid advancements in information and communication technologies, computer-mediated communication channels such as email, web, mobile smart-phones with SMS, social networking websites (Facebook), multimedia websites, and OEM devices provide users with multiple technology choices to seek information. However, no study has compared the…

  8. Pilot-Symbol-Assisted Channel Estimation for Space-Time Coded OFDM Systems

    Directory of Open Access Journals (Sweden)

    Williams Douglas B

    2002-01-01

    Full Text Available Space-time coded orthogonal frequency division multiplexing (OFDM transmitter diversity techniques have been shown to provide an efficient means of achieving near optimal diversity gain in frequency-selective fading channels. For these systems, knowledge of the channel parameters is required at the receivers for diversity combining and decoding. In this paper, we propose a low complexity, bandwidth efficient, pilot-symbol-assisted (PSA channel estimator for multiple transmitter OFDM systems. The pilot symbols are constructed to be nonoverlapping in frequency to allow simultaneous sounding of the multiple channels. The time-varying channel responses are tracked by interpolating a set of estimates obtained through periodically transmitted pilot symbols. Simulations are used to verify the effectiveness of the proposed estimator and to examine its limitations. It is also shown that the PSA channel estimator has a lower computational complexity and better performance than a previously proposed decision-directed minimum mean square error MMSE channel estimator for OFDM transmitter diversity systems.

  9. Statistical mechanics analysis of LDPC coding in MIMO Gaussian channels

    Energy Technology Data Exchange (ETDEWEB)

    Alamino, Roberto C; Saad, David [Neural Computing Research Group, Aston University, Birmingham B4 7ET (United Kingdom)

    2007-10-12

    Using analytical methods of statistical mechanics, we analyse the typical behaviour of a multiple-input multiple-output (MIMO) Gaussian channel with binary inputs under low-density parity-check (LDPC) network coding and joint decoding. The saddle point equations for the replica symmetric solution are found in particular realizations of this channel, including a small and large number of transmitters and receivers. In particular, we examine the cases of a single transmitter, a single receiver and symmetric and asymmetric interference. Both dynamical and thermodynamical transitions from the ferromagnetic solution of perfect decoding to a non-ferromagnetic solution are identified for the cases considered, marking the practical and theoretical limits of the system under the current coding scheme. Numerical results are provided, showing the typical level of improvement/deterioration achieved with respect to the single transmitter/receiver result, for the various cases.

  10. Horizontal Gene Transfer and Assortative Recombination within the Acinetobacter baumannii Clinical Population Provide Genetic Diversity at the Single carO Gene, Encoding a Major Outer Membrane Protein Channel ▿ † ‡

    Science.gov (United States)

    Mussi, María Alejandra; Limansky, Adriana S.; Relling, Verónica; Ravasi, Pablo; Arakaki, Adrián; Actis, Luis A.; Viale, Alejandro M.

    2011-01-01

    We described previously the presence in Acinetobacter baumannii of a novel outer membrane (OM) protein, CarO, which functions as an l-ornithine OM channel and whose loss was concomitant with increased carbapenem resistance among clonally related nosocomial isolates of this opportunistic pathogen. Here, we describe the existence of extensive genetic diversity at the carO gene within the A. baumannii clinical population. The systematic analysis of carO sequences from A. baumannii isolates obtained from public hospitals in Argentina revealed the existence of four highly polymorphic carO variants among them. Sequence polymorphism between the different A. baumannii CarO variants was concentrated in three well-defined protein regions that superimposed mostly to predicted surface-exposed loops. Polymorphism among A. baumannii CarO variants was manifested in differential electrophoretic mobilities, antigenic properties, abilities to form stable oligomeric structures, and l-ornithine influx abilities through the A. baumannii OM under in vivo conditions. Incongruence between the phylogenies of the clinical A. baumannii isolates analyzed and those of the carO variants they harbor suggests the existence of assortative (entire-gene) carO recombinational exchange within the A. baumannii population. Exchange of carO variants possessing differential characteristics mediated by horizontal gene transfer may constitute an A. baumannii population strategy to survive radically changing environmental conditions, such as the leap from inanimate sources to human hosts and vice versa, persistence in a compromised host, and/or survival in health care facilities. PMID:21764928

  11. The M2 Channel

    DEFF Research Database (Denmark)

    Santner, Paul

    Drug resistance of Influenza A against antivirals is an increasing problem. No effective Influenza A drugs targeting the crucial viral protein, the proton transporter M2 are available anymore due to widespread resistance. Thanks to research efforts elucidating M2 protein structure, function and i...... resistance escape routes from drug inhibition. We thereby were hopefully able to provide a platform for the large-scale evaluation of M2 channel activity, inhibitors and resistance....

  12. Characterization of ion channels on subesophageal ganglion neurons from Chinese tarantula Ornithoctonus huwena: Exploring the myth of the spider insensitive to its venom.

    Science.gov (United States)

    Deng, Meichun; Hu, Zhaotun; Cai, Tianfu; Liu, Kai; Wu, Wenfang; Luo, Xuan; Jiang, Liping; Wang, Meichi; Yang, Jing; Xiao, Yucheng; Liang, Songping

    2016-09-15

    Chinese tarantula Ornithoctonus huwena is one of the most venomous spiders distributing in the hilly areas of southern China. In this study, using whole-cell patch-clamp technique we investigated electrophysiological and pharmacological properties of ion channels from tarantula subesophageal ganglion neurons. It was found that the neurons express multiple kinds of ion channels at least including voltage-gated calcium channels, TTX-sensitive sodium channels and two types of potassium channels. They exhibit pharmacological properties similar to mammalian subtypes. Spider calcium channels were sensitive to ω-conotoxin GVIA and diltiazem, two well-known inhibitors of mammalian neuronal high-voltage-activated (HVA) subtypes. 4-Aminopyridine and tetraethylammonium could inhibit spider outward transient and delayed-rectifier potassium channels, respectively. Huwentoxin-I and huwentoxin-IV are two abundant toxic components in the venom of Ornithoctonus huwena. Interestingly, although in our previous work they inhibit HVA calcium channels and TTX-sensitive sodium channels from mammalian sensory neurons, respectively, they fail to affect the subtypes from spider neurons. Moreover, the crude venom has no effect on delayed-rectifier potassium channels and only slightly reduces transient outward potassium channels with an IC50 value of ∼51.3 mg/L. Therefore, our findings provide important evidence for ion channels from spiders having an evolution as self-defense and prey mechanism. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Tracking channel bed resiliency in forested mountain catchments using high temporal resolution channel bed movement

    Science.gov (United States)

    Martin, Sarah E.; Conklin, Martha H.

    2018-01-01

    This study uses continuous-recording load cell pressure sensors in four, high-elevation (1500-1800 m), Sierra Nevada headwater streams to collect high-temporal-resolution, bedload-movement data for investigating the channel bed movement patterns within these streams for water years 2012-2014. Data show an annual pattern where channel bed material in the thalweg starts to build up in early fall, peaks around peak snow melt, and scours back to baseline levels during hydrograph drawdown and base flow. This pattern is punctuated by disturbance and recovery of channel bed material associated with short-term storm events. A conceptual model, linking sediment sources at the channel margins to patterns of channel bed fill and scour in the thalweg, is proposed building on the results of Martin et al. (2014). The material in the thalweg represents a balance between sediment supply from the channel margins and sporadic, conveyor-belt-like downstream transport in the thalweg. The conceptual model highlights not only the importance of production and transport rates but also that seasonal connectedness between the margins and thalweg is a key sediment control, determining the accumulation rate of sediment stores at the margins and the redistribution of sediment from margins to thalweg that feeds the conveyor belt. Disturbance and recovery cycles are observed at multiple temporal scales; but long term, the channel beds are stable, suggesting that the beds act as short-term storage for sediment but are in equilibrium interannually. The feasibility of use for these sensors in forested mountain stream environments is tested. Despite a high failure rate (50%), load cell pressure sensors show potential for high-temporal-resolution bedload measurements, allowing for the collection of channel bed movement data to move beyond time-integrated change measurements - where many of the subtleties of bedload movement patterns may be missed - to continuous and/or real-time measurements. This

  14. Achievable Rates and Scaling Laws for Cognitive Radio Channels

    Directory of Open Access Journals (Sweden)

    Devroye Natasha

    2008-01-01

    Full Text Available Abstract Cognitive radios have the potential to vastly improve communication over wireless channels. We outline recent information theoretic results on the limits of primary and cognitive user communication in single and multiple cognitive user scenarios. We first examine the achievable rate and capacity regions of single user cognitive channels. Results indicate that at medium SNR (0–20 dB, the use of cognition improves rates significantly compared to the currently suggested spectral gap-filling methods of secondary spectrum access. We then study another information theoretic measure, the multiplexing gain. This measure captures the number of point-to-point Gaussian channels contained in a cognitive channel as the SNR tends to infinity. Next, we consider a cognitive network with a single primary user and multiple cognitive users. We show that with single-hop transmission, the sum capacity of the cognitive users scales linearly with the number of users. We further introduce and analyze the primary exclusive radius, inside of which primary receivers are guaranteed a desired outage performance. These results provide guidelines when designing a network with secondary spectrum users.

  15. BK channel modulators: a comprehensive overview

    DEFF Research Database (Denmark)

    Nardi, Antonio; Olesen, Søren-Peter

    2008-01-01

    the notion that the channel represents an innovative and promising drug target. However, after more than ten years of intense research effort both in academia and industry, scientists have yet to witness the approval of a single BK channel modulator for clinical use. On the contrary, three BK openers...... and blockers 4) Marketed and/or investigational drugs with BK-modulating side properties and structural analogues 5) Naturally-occurring BK channel openers and structural analogues 6) Synthetic BK channel openers. This review is intended to provide readers with current opinion on the BK channel as a drug......The large Ca(2+)-activated K(+) channel (BK channel) reflects per excellence the dilemma of the molecular target driven drug discovery process. Significant experimental evidence suggests that the BK channels play a pivotal and specific role in many pathophysiological conditions supporting...

  16. Indoor MIMO Channel Measurement and Modeling

    DEFF Research Database (Denmark)

    Nielsen, Jesper Ødum; Andersen, Jørgen Bach

    2005-01-01

    Forming accurate models of the multiple input multiple output (MIMO) channel is essential both for simulation as well as understanding of the basic properties of the channel. This paper investigates different known models using measurements obtained with a 16x32 MIMO channel sounder for the 5.8GHz...... band. The measurements were carried out in various indoor scenarios including both temporal and spatial aspects of channel changes. The models considered include the so-called Kronecker model, a model proposed by Weichselberger et. al., and a model involving the full covariance matrix, the most...... accurate model for Gaussian channels. For each of the environments different sizes of both the transmitter and receiver antenna arrays are investigated, 2x2 up to 16x32. Generally it was found that in terms of capacity cumulative distribution functions (CDFs) all models fit well for small array sizes...

  17. Voltage-gated Proton Channels

    Science.gov (United States)

    DeCoursey, Thomas E.

    2014-01-01

    Voltage-gated proton channels, HV1, have vaulted from the realm of the esoteric into the forefront of a central question facing ion channel biophysicists, namely the mechanism by which voltage-dependent gating occurs. This transformation is the result of several factors. Identification of the gene in 2006 revealed that proton channels are homologues of the voltage-sensing domain of most other voltage-gated ion channels. Unique, or at least eccentric, properties of proton channels include dimeric architecture with dual conduction pathways, perfect proton selectivity, a single-channel conductance ~103 smaller than most ion channels, voltage-dependent gating that is strongly modulated by the pH gradient, ΔpH, and potent inhibition by Zn2+ (in many species) but an absence of other potent inhibitors. The recent identification of HV1 in three unicellular marine plankton species has dramatically expanded the phylogenetic family tree. Interest in proton channels in their own right has increased as important physiological roles have been identified in many cells. Proton channels trigger the bioluminescent flash of dinoflagellates, facilitate calcification by coccolithophores, regulate pH-dependent processes in eggs and sperm during fertilization, secrete acid to control the pH of airway fluids, facilitate histamine secretion by basophils, and play a signaling role in facilitating B-cell receptor mediated responses in B lymphocytes. The most elaborate and best-established functions occur in phagocytes, where proton channels optimize the activity of NADPH oxidase, an important producer of reactive oxygen species. Proton efflux mediated by HV1 balances the charge translocated across the membrane by electrons through NADPH oxidase, minimizes changes in cytoplasmic and phagosomal pH, limits osmotic swelling of the phagosome, and provides substrate H+ for the production of H2O2 and HOCl, reactive oxygen species crucial to killing pathogens. PMID:23798303

  18. Precisely synchronous and cascadable multi-channel arbitrary waveform generator

    Science.gov (United States)

    Liu, Ke; Tian, Shulin; Guo, Guangkun; Xiao, Yindong

    2017-03-01

    The output bandwidth and the capability to generate multiple analog outputs with accurately adjustable relative phase are important specifications of arbitrary waveform generator (AWG). To increase the output bandwidth, AWG with a multi-memory paralleled direct digital synthesizer structure (DDS) was proposed to break through operating speed limitations of memory and field programmable gate array. But this structure does complicate synchronization of the analog outputs. This paper proposes a structure for synchronization of the outputs of multi-channel high speed AWG that generates arbitrary waveforms using a multi-memory paralleled DDS. Careful distribution of the clock and trigger signals enables elimination of the random initial phase caused by the frequency divider. Based on this structure, a four-channel 600 mega samples per second AWG is designed. An embedded clock synchronization calibration module is designed to eliminate the random phase difference caused by a frequency divider inside a digital-to-analog converter. The AWG provides a 240 MHz bandwidth, 16 mega-samples storage depth, inter-channel initial skew accuracy less than 150 ps, and 0.0001° phase resolution, which can be used to generate two pairs of I/Q signals or a pair of differential I/Q signals for the quadrature modulator. Additionally, more AWGs can be cascaded to obtain more output channels with an output timing skew between adjacent channels of less than 1.6 ns.

  19. Spatial-Temporal Correlation Properties of the 3GPP Spatial Channel Model and the Kronecker MIMO Channel Model

    Directory of Open Access Journals (Sweden)

    Cheng-Xiang Wang

    2007-02-01

    Full Text Available The performance of multiple-input multiple-output (MIMO systems is greatly influenced by the spatial-temporal correlation properties of the underlying MIMO channels. This paper investigates the spatial-temporal correlation characteristics of the spatial channel model (SCM in the Third Generation Partnership Project (3GPP and the Kronecker-based stochastic model (KBSM at three levels, namely, the cluster level, link level, and system level. The KBSM has both the spatial separability and spatial-temporal separability at all the three levels. The spatial-temporal separability is observed for the SCM only at the system level, but not at the cluster and link levels. The SCM shows the spatial separability at the link and system levels, but not at the cluster level since its spatial correlation is related to the joint distribution of the angle of arrival (AoA and angle of departure (AoD. The KBSM with the Gaussian-shaped power azimuth spectrum (PAS is found to fit best the 3GPP SCM in terms of the spatial correlations. Despite its simplicity and analytical tractability, the KBSM is restricted to model only the average spatial-temporal behavior of MIMO channels. The SCM provides more insights of the variations of different MIMO channel realizations, but the implementation complexity is relatively high.

  20. ``Just Another Distribution Channel?''

    Science.gov (United States)

    Lemstra, Wolter; de Leeuw, Gerd-Jan; van de Kar, Els; Brand, Paul

    The telecommunications-centric business model of mobile operators is under attack due to technological convergence in the communication and content industries. This has resulted in a plethora of academic contributions on the design of new business models and service platform architectures. However, a discussion of the challenges that operators are facing in adopting these models is lacking. We assess these challenges by considering the mobile network as part of the value system of the content industry. We will argue that from the perspective of a content provider the mobile network is ‘just another’ distribution channel. Strategic options available for the mobile communication operators are to deliver an excellent distribution channel for content delivery or to move upwards in the value chain by becoming a content aggregator. To become a mobile content aggregator operators will have to develop or acquire complementary resources and capabilities. Whether this strategic option is sustainable remains open.

  1. Price leadership within a marketing channel: A cointegration study

    NARCIS (Netherlands)

    Kuiper, W.E.; Meulenberg, M.T.G.

    2004-01-01

    Building upon a multiple-product channel structure, this paper develops a model to test channel price leadership on the basis of time series observations on retail and wholesale prices and using absence of double marginalisation as a criterion for channel price leadership. The model studies

  2. SWIPT in Multiuser MIMO Decode-and-Forward Relay Broadcasting Channel with Energy Harvesting Relays

    KAUST Repository

    Benkhelifa, Fatma

    2017-02-09

    In this paper, we consider a multiuser multiple- input multiple-output (MIMO) decode-and-forward (DF) relay broadcasting channel (BC) with single source, multiple energy harvesting relays and multiple destinations. Since the end-to-end sum rate maximization problem is intractable, we tackle a simplified problem where we maximize the sum of the harvested energy at the relays, we employ the block diagonalization (BD) procedure at the source, and we mitigate the interference between the relay- destination channels. The interference mitigation at the destinations is managed in two ways: either to fix the interference covariance matrices at the destination and update them at each iteration until convergence, or to cancel the interference using an algorithm similar to the BD method. We provide numerical results to show the relevance of our proposed solution.

  3. Channelization Issues with Fairness Considerations for MU-MIMO Precoding Based UTRA-LTE/TDD Systems

    DEFF Research Database (Denmark)

    Rahman, Muhammad Imadur; Wang, Yuanye; Das, Suvra

    2008-01-01

    evaluated the resource allocation fairness issue when two well-known linear MU-MIMO precoding is used on a UTRA-LTE system. User grouping issue is dealt with when SDMA component is considered in the system. The results in this work provides an indicative analysis of the usability of different channelization......In a pre-coded Multi User Multiple Input Multiple Output (MU-MIMO) system, the channelization can be done either by using any of the two basic access techniques, namely Orthogonal Frequency Division Multiple Access (OFDMA) and Space Division Multiple Access (SDMA), or by combining them. From...... resource allocation point of view, choice of any technique will require different fairness conditions among users. In this paper, we have studied these different fairness conditions when combined with basic or joint access schemes mentioned above, while applied in a MU-MIMO based UTRA-LTE system. We have...

  4. Distortion Exponent in MIMO Channels with Feedback

    CERN Document Server

    Gunduz, Deniz; Poor, H Vincent

    2009-01-01

    The transmission of a Gaussian source over a block-fading multiple antenna channel in the presence of a feedback link is considered. The feedback link is assumed to be an error and delay free link of capacity 1 bit per channel use. Under the short-term power constraint, the optimal exponential behavior of the end-to-end average distortion is characterized for all source-channel bandwidth ratios. It is shown that the optimal transmission strategy is successive refinement source coding followed by progressive transmission over the channel, in which the channel block is allocated dynamically among the layers based on the channel state using the feedback link as an instantaneous automatic repeat request (ARQ) signal.

  5. ASIC3 channels in multimodal sensory perception.

    Science.gov (United States)

    Li, Wei-Guang; Xu, Tian-Le

    2011-01-19

    Acid-sensing ion channels (ASICs), which are members of the sodium-selective cation channels belonging to the epithelial sodium channel/degenerin (ENaC/DEG) family, act as membrane-bound receptors for extracellular protons as well as nonproton ligands. At least five ASIC subunits have been identified in mammalian neurons, which form both homotrimeric and heterotrimeric channels. The highly proton sensitive ASIC3 channels are predominantly distributed in peripheral sensory neurons, correlating with their roles in multimodal sensory perception, including nociception, mechanosensation, and chemosensation. Different from other ASIC subunit composing ion channels, ASIC3 channels can mediate a sustained window current in response to mild extracellular acidosis (pH 7.3-6.7), which often occurs accompanied by many sensory stimuli. Furthermore, recent evidence indicates that the sustained component of ASIC3 currents can be enhanced by nonproton ligands including the endogenous metabolite agmatine. In this review, we first summarize the growing body of evidence for the involvement of ASIC3 channels in multimodal sensory perception and then discuss the potential mechanisms underlying ASIC3 activation and mediation of sensory perception, with a special emphasis on its role in nociception. We conclude that ASIC3 activation and modulation by diverse sensory stimuli represent a new avenue for understanding the role of ASIC3 channels in sensory perception. Furthermore, the emerging implications of ASIC3 channels in multiple sensory dysfunctions including nociception allow the development of new pharmacotherapy.

  6. VKCDB: Voltage-gated potassium channel database

    Directory of Open Access Journals (Sweden)

    Gallin Warren J

    2004-01-01

    Full Text Available Abstract Background The family of voltage-gated potassium channels comprises a functionally diverse group of membrane proteins. They help maintain and regulate the potassium ion-based component of the membrane potential and are thus central to many critical physiological processes. VKCDB (Voltage-gated potassium [K] Channel DataBase is a database of structural and functional data on these channels. It is designed as a resource for research on the molecular basis of voltage-gated potassium channel function. Description Voltage-gated potassium channel sequences were identified by using BLASTP to search GENBANK and SWISSPROT. Annotations for all voltage-gated potassium channels were selectively parsed and integrated into VKCDB. Electrophysiological and pharmacological data for the channels were collected from published journal articles. Transmembrane domain predictions by TMHMM and PHD are included for each VKCDB entry. Multiple sequence alignments of conserved domains of channels of the four Kv families and the KCNQ family are also included. Currently VKCDB contains 346 channel entries. It can be browsed and searched using a set of functionally relevant categories. Protein sequences can also be searched using a local BLAST engine. Conclusions VKCDB is a resource for comparative studies of voltage-gated potassium channels. The methods used to construct VKCDB are general; they can be used to create specialized databases for other protein families. VKCDB is accessible at http://vkcdb.biology.ualberta.ca.

  7. Rank-Constrained Beamforming for MIMO Cognitive Interference Channel

    Directory of Open Access Journals (Sweden)

    Duoying Zhang

    2016-01-01

    Full Text Available This paper considers the spectrum sharing multiple-input multiple-output (MIMO cognitive interference channel, in which multiple primary users (PUs coexist with multiple secondary users (SUs. Interference alignment (IA approach is introduced that guarantees that secondary users access the licensed spectrum without causing harmful interference to the PUs. A rank-constrained beamforming design is proposed where the rank of the interferences and the desired signals is concerned. The standard interferences metric for the primary link, that is, interference temperature, is investigated and redesigned. The work provides a further improvement that optimizes the dimension of the interferences in the cognitive interference channel, instead of the power of the interference leakage. Due to the nonconvexity of the rank, the developed optimization problems are further approximated as convex form and are solved via choosing the transmitter precoder and receiver subspace iteratively. Numerical results show that the proposed designs can improve the achievable degree of freedom (DoF of the primary links and provide the considerable sum rate for both secondary and primary transmissions under the rank constraints.

  8. Optimal Data Transmission on MIMO OFDM Channels

    Science.gov (United States)

    2008-12-01

    standard with OFDM using different values of coding rates. International Telecommunications Union (ITU) channel models are selected for the wireless...AND ABBREVIATIONS AWGN Additive White Gaussian Noise BER Bit Error Rate BPSK Binary Phase Sift Keying CDMA Code Division Multiple Access CSI...division multiple access ( CDMA ) and orthogonal frequency division multiplexing (OFDM). The latter, in particular, is widely used in several standards

  9. Low-mobility channel tracking for MIMO-OFDM communication systems

    Science.gov (United States)

    Pagadarai, Srikanth; Wyglinski, Alexander M.; Anderson, Christopher R.

    2013-12-01

    It is now well understood that by exploiting the available additional spatial dimensions, multiple-input multiple-output (MIMO) communication systems provide capacity gains, compared to a single-input single-output systems without increasing the overall transmit power or requiring additional bandwidth. However, these large capacity gains are feasible only when the perfect knowledge of the channel is available to the receiver. Consequently, when the channel knowledge is imperfect, as is common in practical settings, the impact of the achievable capacity needs to be evaluated. In this study, we begin with a general MIMO framework at the outset and specialize it to the case of orthogonal frequency division multiplexing (OFDM) systems by decoupling channel estimation from data detection. Cyclic-prefixed OFDM systems have attracted widespread interest due to several appealing characteristics not least of which is the fact that a single-tap frequency-domain equalizer per subcarrier is sufficient due to the circulant structure of the resulting channel matrix. We consider a low-mobility wireless channel which exhibits inter-block channel variations and apply Kalman tracking when MIMO-OFDM communication is performed. Furthermore, we consider the signal transmission to contain a stream of training and information symbols followed by information symbols alone. By relying on predicted channel states when training symbols are absent, we aim to understand how the improvements in channel capacity are affected by imperfect channel knowledge. We show that the Kalman recursion procedure can be simplified by the optimal minimum mean square error training design. Using the simplified recursion, we derive capacity upper and lower bounds to evaluate the performance of the system.

  10. Channel Wall Landslides

    Science.gov (United States)

    2005-01-01

    [figure removed for brevity, see original site] The multiple landslides in this VIS image occur along a steep channel wall. Note the large impact crater in the context image. The formation of the crater may have initially weakened that area of the surface prior to channel formation. Image information: VIS instrument. Latitude -2.7, Longitude 324.8 East (35.2 West). 19 meter/pixel resolution. Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time. NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

  11. Wavelet based multicarrier code division multiple access ...

    African Journals Online (AJOL)

    This paper presents the study on Wavelet transform based Multicarrier Code Division Multiple Access (MC-CDMA) system for a downlink wireless channel. The performance of the system is studied for Additive White Gaussian Noise Channel (AWGN) and slowly varying multipath channels. The bit error rate (BER) versus ...

  12. Precoder and decoder prediction in time-varying MIMO channel

    DEFF Research Database (Denmark)

    Nguyen, Tuan Hung; Leus, Geert; Khaled, Nadia

    2005-01-01

    In mobile communications, time varying channels make the available channel information out of date. Timely updating the channel state is an obvious solution to improve the system performance in a time varying channel. However, a better knowledge of the channel comes at the cost of a decrease...... in the system throughput. Thus, predicting the future channel conditions can improve not only the performance but also the throughput of many types of wireless systems. This is especially true for a wireless system where multiple antennas are applied at both link ends. In this report we propose and evaluate...

  13. Rician Channel Modeling for Multiprobe Anechoic Chamber Setups

    DEFF Research Database (Denmark)

    Fan, Wei; Kyösti, Pekka; Hentilä, Lassi

    2014-01-01

    This paper discusses over the air (OTA) testing for multiple input multiple output (MIMO) capable terminals, with emphasis on modeling Rician channel models in the multi-probe anechoic chamber setups. A technique to model Rician channels is proposed. The line-of-sight (LOS) component...

  14. Fast Estimation of Outage Probabilities in MIMO Channels

    NARCIS (Netherlands)

    Srinivasan, R.; Tiba, G.

    2004-01-01

    Fast estimation methods for small outage probabilities of signaling in fading multiple-input multiple-output (MIMO) channels are developed. Communication over such channels is of much current interest, and quick and accurate methods for estimating outage capacities are needed. The methods described

  15. 3D Channel Model Emulation in a MIMO OTA Setup

    DEFF Research Database (Denmark)

    Fan, Wei; Kyösti, Pekka; Sun, Fan

    2013-01-01

    This paper presents a new channel reconstruction technique for 3D geometry-based channels in a multi-probe based MIMO OTA setup. The proposed method provides a general channel reconstruction framework for any spherical power spectrum. The channel reconstruction is formed as convex optimization...

  16. Compressed sensing MRI with multi-channel data using multi-core processors.

    Science.gov (United States)

    Chang, Ching-Hua; Ji, Jim

    2009-01-01

    Compressed sensing (CS) has emerged as a promising method in the field of magnetic resonance imaging. Taking advantage of the signal sparsity in certain domain via L(1) minimization, CS requires only reduced k-space data to reconstruct an image. Since most clinical MRI scanners are equipped with multi-channel receiver systems, integrating CS with multi-channel systems may not only shorten the scan time but provide a better image quality. However, significant computation time is required to perform CS reconstruction. Furthermore, this burden will be scaled by the number of channels. In this paper, we proposed a reconstruction procedure, which uses multi-core processors to accelerate CS reconstruction from multiple channel data. The performance was tested in terms of comparing to different image sizes and using different number cores of CPU. Experimentally, it shows that the maximum efficiency benefits from parallelizing the CS reconstructions, pipelining multi-channel data on multi-core processors and choosing the numbers of channels as multiple numbers of cores.

  17. Channel Statistics for MIMO Handsets in Data Mode

    DEFF Research Database (Denmark)

    Nielsen, Jesper Ødum; Yanakiev, Boyan; Barrio, Samantha Caporal Del

    2014-01-01

    The presented work is based on a large dual- band, dual-base outdoor-to-indoor multiple-input multiple- output (MIMO) channel measurement campaign, involving ten different realistic MIMO handsets, held in data mode by eight test users. Various different use cases (UCs) are measured. Statistics on...... on the channel capacity, mean effective gain (MEG), branch power ratio (BPR), and correlation coefficients between Rx, Tx, and cross-link channels are presented....

  18. Citizens and service channels: channel choice and channel management implications

    NARCIS (Netherlands)

    Pieterson, Willem Jan

    2010-01-01

    The arrival of electronic channels in the 1990s has had a huge impact on governmental service delivery. The new channels have led to many new opportunities to improve public service delivery, not only in terms of citizen satisfaction, but also in cost reduction for governmental agencies. However,

  19. Channel nut tool

    Science.gov (United States)

    Olson, Marvin

    2016-01-12

    A method, system, and apparatus for installing channel nuts includes a shank, a handle formed on a first end of a shank, and an end piece with a threaded shaft configured to receive a channel nut formed on the second end of the shaft. The tool can be used to insert or remove a channel nut in a channel framing system and then removed from the channel nut.

  20. Performance Analysis of Signal Detection using Quantized Received Signals of Linear Vector Channel

    OpenAIRE

    Nakamura, Kazutaka

    2008-01-01

    Performance analysis of optimal signal detection using quantized received signals of a linear vector channel, which is an extension of code-division multiple-access (CDMA) or multiple-input multiple-output (MIMO) channels, in the large system limit, is presented in this paper. Here the dimensions of channel input and output are both sent to infinity while their ratio remains fixed. An optimal detector is one that uses a true channel model, true distribution of input signals, and perfect knowl...

  1. Multiple description coding based on multiple-bitsteam wavelet zero-tree image compression

    Science.gov (United States)

    Song, Daewon; Chen, Chang Wen; Cao, Lei

    2004-10-01

    Multiple description coding (MDC) is a well-known robust data compression algorithm designed to minimize the distortion caused by data loss in packet-based communication systems. Several MDC schemes for transmitting wavelet compressed images have been developed. However, these MDC schemes cannot be adopted for digital mobile wireless applications where both packet loss and bit error are present, because individual description in these MDC schemes usually does not have adequate error resilience capability to combat the bit error in transmission. In this paper, we propose an algorithm to achieve robust communication over error prone transmission channels with both packet loss and bit error. We integrate the multiple description scalar quantization (MDSQ) with the multiple wavelet tree image coding method in order to provide an excellent error resilient capability. Two descriptions are generated independently by using index assignment of MDSQ. For each description, multiple sub-sampling is applied to split the wavelet coefficients of the source image into multiple sub-sources. Each sub-source is then entropy coded using the SPIHT algorithm and followed by a channel coding scheme that combines cyclic redundancy code (CRC) and rate compatible punctured convolutional (RCPC) code to offer unequal error protection to the entropy coded bits. The unequal error protection channel coding rate is designed based on the bit error sensitivity of different bit planes to achieve maximum end-to-end quality of service. Experimental results show that the proposed scheme not only exhibits an excellent error resilient performance but also demonstrates graceful degradation over error prone channels with changing rate of packet loss and bit error.

  2. Channel and Timeslot Co-Scheduling with Minimal Channel Switching for Data Aggregation in MWSNs

    Directory of Open Access Journals (Sweden)

    Sanggil Yeoum

    2017-05-01

    Full Text Available Collision-free transmission and efficient data transfer between nodes can be achieved through a set of channels in multichannel wireless sensor networks (MWSNs. While using multiple channels, we have to carefully consider channel interference, channel and time slot (resources optimization, channel switching delay, and energy consumption. Since sensor nodes operate on low battery power, the energy consumed in channel switching becomes an important challenge. In this paper, we propose channel and time slot scheduling for minimal channel switching in MWSNs, while achieving efficient and collision-free transmission between nodes. The proposed scheme constructs a duty-cycled tree while reducing the amount of channel switching. As a next step, collision-free time slots are assigned to every node based on the minimal data collection delay. The experimental results demonstrate that the validity of our scheme reduces the amount of channel switching by 17.5%, reduces energy consumption for channel switching by 28%, and reduces the schedule length by 46%, as compared to the existing schemes.

  3. Secure Broadcasting with Imperfect Channel State Information at the Transmitter

    KAUST Repository

    Hyadi, Amal

    2015-11-13

    We investigate the problem of secure broadcasting over fast fading channels with imperfect main channel state information (CSI) at the transmitter. In particular, we analyze the effect of the noisy estimation of the main CSI on the throughput of a broadcast channel where the transmission is intended for multiple legitimate receivers in the presence of an eavesdropper. Besides, we consider the realistic case where the transmitter is only aware of the statistics of the eavesdropper’s CSI and not of its channel’s realizations. First, we discuss the common message transmission case where the source broadcasts the same information to all the receivers, and we provide an upper and a lower bounds on the ergodic secrecy capacity. For this case, we show that the secrecy rate is limited by the legitimate receiver having, on average, the worst main channel link and we prove that a non-zero secrecy rate can still be achieved even when the CSI at the transmitter is noisy. Then, we look at the independent messages case where the transmitter broadcasts multiple messages to the receivers, and each intended user is interested in an independent message. For this case, we present an expression for the achievable secrecy sum-rate and an upper bound on the secrecy sum-capacity and we show that, in the limit of large number of legitimate receivers K, our achievable secrecy sum-rate follows the scaling law log((1−) log(K)), where is the estimation error variance of the main CSI. The special cases of high SNR, perfect and no-main CSI are also analyzed. Analytical derivations and numerical results are presented to illustrate the obtained expressions for the case of independent and identically distributed Rayleigh fading channels.

  4. Interactions Between Channel Topography and Hydrokinetic Turbines: Sediment Transport, Turbine Performance, and Wake Characteristics

    Science.gov (United States)

    Hill, Craig Steven

    Accelerating marine hydrokinetic (MHK) renewable energy development towards commercial viability requires investigating interactions between the engineered environment and its surrounding physical and biological environments. Complex and energetic hydrodynamic and morphodynamic environments desired for such energy conversion installations present difficulties for designing efficient yet robust sustainable devices, while permitting agency uncertainties regarding MHK device environmental interactions result in lengthy and costly processes prior to installing and demonstrating emerging technologies. A research program at St. Anthony Falls Laboratory (SAFL), University of Minnesota, utilized multi-scale physical experiments to study the interactions between axial-flow hydrokinetic turbines, turbulent open channel flow, sediment transport, turbulent turbine wakes, and complex hydro-morphodynamic processes in channels. Model axial-flow current-driven three-bladed turbines (rotor diameters, dT = 0.15m and 0.5m) were installed in open channel flumes with both erodible and non-erodible substrates. Device-induced local scour was monitored over several hydraulic conditions and material sizes. Synchronous velocity, bed elevation and turbine performance measurements provide an indication into the effect channel topography has on device performance. Complimentary experiments were performed in a realistic meandering outdoor research channel with active sediment transport to investigate device interactions with bedform migration and secondary turbulent flow patterns in asymmetric channel environments. The suite of experiments undertaken during this research program at SAFL in multiple channels with stationary and mobile substrates under a variety of turbine configurations provides an in-depth investigation into how axial-flow hydrokinetic devices respond to turbulent channel flow and topographic complexity, and how they impact local and far-field sediment transport characteristics

  5. Multiple Pregnancy

    Science.gov (United States)

    ... multiple pregnancy affect fetal growth? Are tests for genetic disorders as accurate in multiple pregnancies? How can multiple pregnancy affect delivery? Can multiple pregnancy affect my risk of postpartum depression? Can I breastfeed if I have multiples? Glossary ...

  6. T₂ mapping provides multiple approaches for the characterization of muscle involvement in neuromuscular diseases: a cross-sectional study of lower leg muscles in 5-15-year-old boys with Duchenne muscular dystrophy.

    Science.gov (United States)

    Arpan, Ishu; Forbes, Sean C; Lott, Donovan J; Senesac, Claudia R; Daniels, Michael J; Triplett, William T; Deol, Jasjit K; Sweeney, H Lee; Walter, Glenn A; Vandenborne, Krista

    2013-03-01

    Skeletal muscles of children with Duchenne muscular dystrophy (DMD) show enhanced susceptibility to damage and progressive lipid infiltration, which contribute to an increase in the MR proton transverse relaxation time (T₂). Therefore, the examination of T₂ changes in individual muscles may be useful for the monitoring of disease progression in DMD. In this study, we used the mean T₂, percentage of elevated pixels and T₂ heterogeneity to assess changes in the composition of dystrophic muscles. In addition, we used fat saturation to distinguish T₂ changes caused by edema and inflammation from fat infiltration in muscles. Thirty subjects with DMD and 15 age-matched controls underwent T₂ -weighted imaging of their lower leg using a 3-T MR system. T₂ maps were developed and four lower leg muscles were manually traced (soleus, medial gastrocnemius, peroneal and tibialis anterior). The mean T₂ of the traced regions of interest, width of the T₂ histograms and percentage of elevated pixels were calculated. We found that, even in young children with DMD, lower leg muscles showed elevated mean T₂, were more heterogeneous and had a greater percentage of elevated pixels than in controls. T₂ measures decreased with fat saturation, but were still higher (P < 0.05) in dystrophic muscles than in controls. Further, T₂ measures showed positive correlations with timed functional tests (r = 0.23-0.79). The elevated T₂ measures with and without fat saturation at all ages of DMD examined (5-15 years) compared with unaffected controls indicate that the dystrophic muscles have increased regions of damage, edema and fat infiltration. This study shows that T₂ mapping provides multiple approaches that can be used effectively to characterize muscle tissue in children with DMD, even in the early stages of the disease. Therefore, T₂ mapping may prove to be clinically useful in the monitoring of muscle changes caused by the disease process or by therapeutic

  7. Family-centredness of professionals who support people with profound intellectual and multiple disabilities: validation of the Dutch 'Measure of Processes of Care for Service Providers' (MPOC-SP-PIMD).

    Science.gov (United States)

    Jansen, Suzanne L G; van der Putten, Annette A J; Post, Wendy J; Vlaskamp, Carla

    2014-07-01

    A Dutch version of the 'Measure of Processes of Care for Service Providers' (MPOC-SP) was developed to determine the extent to which professionals apply the principles of family-centred care in the rehabilitation of children with physical disabilities. However, no data were available on the reliability and construct validity of this instrument when it comes to supporting people with profound intellectual and multiple disabilities (PIMD). This study aimed to validate an adapted version of the Dutch MPOC-SP for assessing the family-centred behaviours of professionals who support this group (MPOC-SP-PIMD). A total of 105 professionals took part in the study. A Mokken scale analysis was conducted to determine whether the instrument satisfied the assumptions of both monotone homogeneity and double monotonicity. Loevinger's scalability coefficient (H) was used for the scalability of the entire scale and of each item separately. Rho was calculated as a measure of the internal consistency of the scales. The analyses resulted in two scales: a nine-item scale interpreted as 'Showing Interpersonal Sensitivity', with H=.39 and rho=.76, and a seven-item scale interpreted as 'Treating People Respectfully', with H=.49 and rho=.78. A validated version of the MPOC-SP-PIMD, suitable for supporting people with PIMD, consists of a subset of two scales from the original Dutch MPOC-SP. This instrument can be used to compare the family-centredness of professionals with parent's expectations and views. This information can be used in practice to match the support to the needs of the parents and family of the child with PIMD. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. Channel coding techniques for wireless communications

    CERN Document Server

    Deergha Rao, K

    2015-01-01

    The book discusses modern channel coding techniques for wireless communications such as turbo codes, low-density parity check (LDPC) codes, space–time (ST) coding, RS (or Reed–Solomon) codes and convolutional codes. Many illustrative examples are included in each chapter for easy understanding of the coding techniques. The text is integrated with MATLAB-based programs to enhance the understanding of the subject’s underlying theories. It includes current topics of increasing importance such as turbo codes, LDPC codes, Luby transform (LT) codes, Raptor codes, and ST coding in detail, in addition to the traditional codes such as cyclic codes, BCH (or Bose–Chaudhuri–Hocquenghem) and RS codes and convolutional codes. Multiple-input and multiple-output (MIMO) communications is a multiple antenna technology, which is an effective method for high-speed or high-reliability wireless communications. PC-based MATLAB m-files for the illustrative examples are provided on the book page on Springer.com for free dow...

  9. Multiple sclerosis; Multiple Sklerose

    Energy Technology Data Exchange (ETDEWEB)

    Grunwald, I.Q.; Kuehn, A.L.; Backens, M.; Papanagiotou, P. [Universitaet des Saarlandes, Abteilung fuer Diagnostische und Interventionelle Neuroradiologie, Radiologische Klinik, Homburg/Saar (Germany); Shariat, K. [Universitaet des Saarlandes, Klinik fuer Neurochirurgie, Homburg/Saar (Germany); Kostopoulos, P. [Universitaet des Saarlandes, Klinik fuer Neurologie, Homburg/Saar (Germany)

    2008-06-15

    Multiple sclerosis is the most common chronic inflammatory disease of myelin with interspersed lesions in the white matter of the central nervous system. Magnetic resonance imaging (MRI) plays a key role in the diagnosis and monitoring of white matter diseases. This article focuses on key findings in multiple sclerosis as detected by MRI. (orig.) [German] Die Multiple Sklerose (MS) ist die haeufigste chronisch-entzuendliche Erkrankung des Myelins mit eingesprengten Laesionen im Bereich der weissen Substanz des zentralen Nervensystems. Die Magnetresonanztomographie (MRT) hat bei der Diagnosestellung und Verlaufskontrolle eine Schluesselrolle. Dieser Artikel befasst sich mit Hauptcharakteristika der MR-Bildbebung. (orig.)

  10. Stability of flowing open fluidic channels

    Directory of Open Access Journals (Sweden)

    Jue Nee Tan

    2013-02-01

    Full Text Available Open fluidic systems have a distinct advantage over enclosed channels in that the fluids exposed nature makes for easy external interaction, this finds uses in introduction of samples by adding liquid droplets or from the surrounding gaseous medium. This work investigates flowing open channels and films, which can potentially make use of the open section of the system as an external interface, before bringing the sample into an enclosed channel. Clearly, in this scenario a key factor is the stability of the flowing open fluid. The open channels investigated include a straight open channel defined by a narrow strip of solid surface, the edges of which allow large contact angle hysteresis, and a wider structure allowing for multiple inputs and outputs. A model is developed for fluid flow, and the findings used to describe the process of failure in both cases.

  11. The suitability of SiGe multiple quantum well modulators for short reach DWDM optical interconnects.

    Science.gov (United States)

    Kekatpure, Rohan D; Lentine, Anthony

    2013-03-11

    We describe calculations that address the suitability at using silicon-germanium multiple quantum well (MQW) modulators in dense wavelength division multiplexed (DWDM) short reach optical interconnects that vary over a significant temperature range. Our calculations indicate that there is a tradeoff between the number of channels, the temperature range and laser power required. Twenty to forty DWDM channels at 100 GHz and 50 GHz channel spacing is possible in DWDM links with a ~ 12° temperature range with less than a 1 dB laser power penalty compared to the optimum single channel, single temperature case. The same number of channels can be operated over a wider 37° temperature range with laser power penalties of 3 dB. It shows that, even for DWDM systems, silicon-germanium modulators might provide an alternative to ring and disk resonant modulators without the need for stringent (< 1 °C) temperature control.

  12. Miniature biotelemeter giving 10 channels of wideband biomedical data.

    Science.gov (United States)

    Carraway, J.

    1972-01-01

    A miniature biotelemeter has been developed for sensing and transmitting multiple channels of wideband biomedical data over a radio link. Its small size and weight make it capable of being carried by free-moving laboratory animals as small as rats. Ten data channels each of 5-kHz data bandwidth are provided to permit monitoring of a wide variety of physiological signals. Multichannel telemetry of electroencephalograms, electrocardiograms, electromyograms, state functions, and dynamic processes such as blood flow and body chemistry are possible applications. Utilization of newly available monolithic chip components, low-power COS/MOS MSI digital logic, and state-of-the-art hybrid mounting techniques makes this novel device useful for both research and clinical bioinstrumentation.

  13. Estimation of channel impulse response and FPGA simulation

    Directory of Open Access Journals (Sweden)

    YU Longjie

    2015-02-01

    Full Text Available Wideband code division multiple access (WCDMA is a 3G wireless communication network.The common pilot channel in downlink of WCDMA provides an effective method to estimate the channel impulse response.In this paper,universal software radio peripheral (USRP is utilized to sample and process WCDMA signal which is emitted by China Unicom base station.Firstly,the received signal is pre-processed with filtering and down-sampling.Secondly,fast algorithm of WCDMA cell search is fulfilled.Thirdly,frequency shift caused by USRP′s crystal oscillator is checked and compensated.Eventually,channel impulse response is estimated.In this paper,MATLAB is used to describe the above algorithm and field programmable gate array (FPGA is used to simulate algorithm.In the process of simulation,pipeline and IP core multiplexing are introduced.In the case of 32 MHz clock frequency,FPGA simulation time is 80.861 ms.Simulation results show that FPGA is able to estimate the channel impulse response quickly and accurately with less hardware resources.

  14. Voltage-Dependent Gating: Novel Insights from KCNQ1 Channels

    Science.gov (United States)

    Cui, Jianmin

    2016-01-01

    Gating of voltage-dependent cation channels involves three general molecular processes: voltage sensor activation, sensor-pore coupling, and pore opening. KCNQ1 is a voltage-gated potassium (Kv) channel whose distinctive properties have provided novel insights on fundamental principles of voltage-dependent gating. 1) Similar to other Kv channels, KCNQ1 voltage sensor activation undergoes two resolvable steps; but, unique to KCNQ1, the pore opens at both the intermediate and activated state of voltage sensor activation. The voltage sensor-pore coupling differs in the intermediate-open and the activated-open states, resulting in changes of open pore properties during voltage sensor activation. 2) The voltage sensor-pore coupling and pore opening require the membrane lipid PIP2 and intracellular ATP, respectively, as cofactors, thus voltage-dependent gating is dependent on multiple stimuli, including the binding of intracellular signaling molecules. These mechanisms underlie the extraordinary KCNE1 subunit modification of the KCNQ1 channel and have significant physiological implications. PMID:26745405

  15. Mapping out the customer’s journey : customer search strategy as a basis for channel management

    NARCIS (Netherlands)

    Drs Robert van Ossenbruggen; Dr. Gerrita van der Veen

    2015-01-01

    Many companies tailor their communication and interaction with customers by segmenting them into channel usage groups. This study argues that simply focusing on channels has limited effectiveness as increasingly customers today use multiple channels, the online channel contains many different forms,

  16. [Memory and potassium channels].

    Science.gov (United States)

    Solntseva, E I; Bukanova, Iu V; Skrebitskiĭ, V G

    2003-01-01

    The K(+)-channels of the surface membrane play a crucial role in the generation of electrical activity of a neuron. There is a large diversity of the K(+)-channels that depends on a great number (over 200) of genes encoding channels proteins. An evolutionary conservation of channel's proteins is determined. The K(+)-channels were found to have a great importance in the memory processes. It was shown on different model systems that K(+)-current of the surface membrane decreases during the learning. The antagonists of K(+)-channels were found to improve the learning and memory. It was revealed in electrophysiological experiments that K(+)-channels antagonists can either themselves induce a long-term synaptic potentiation or intensify the synaptic potentiation induced by a tetanization. The disfunction of K(+)-channels is believed to be an important link in the mechanisms of memory disturbances. In animal mutants with K(+)-channels disfunction, learning and memory are deficient. In behavioral experiments, the use of K(+)-channels openers make the learning worse. Amnesia caused by cerebral ischemia is explained by strong activity of K(+)-channels which not only inhibits neuronal excitement but also causes neurodegeneration. The question on the K(+)-channels involvement into pathophysiology of Alzheimer's disease is discussed. Neurotoxic peptide beta-amyloid, which is supposed to be involved into mechanisms of Alzheimer's disease, modulates K(+)-channels function. The effect of beta-amyloid depends on the subtype of K(+)-channels: A-channels are inhibited, and KDR-channels, on the contrary, become stronger. The effect of the cognitive enhancers (vinpocetine, piracetam, tacrine, linopirdine) on K(+)-current also depends on the subtype of K(+)-channels. Slow-inactivating K(+)-currents (IDR, IK(Ca), IM) are inhibited in the presence of these drugs, while fast-in-activating K(+)-current (A-current) remains unchanged or even increases.

  17. Modelagem por meio de teoria de filas do tradeoff entre investir em canais de atendimento e satisfazer o nível de serviço em provedores INTERNET A queueing model to analyse the tradeoff between investing in attending channels and satisfying service level in INTERNET providers

    Directory of Open Access Journals (Sweden)

    Gisele Castro Fontanella

    1997-12-01

    simplest one is when the user connects to a provider's attending channel by an ordinary telephone line. Finding an available channel may not be an easy task, especially during peak hours. This results in a problem for the providers, which is to determine the optimal relationship between the number of users and the number of attending channels. To solve this problem, a provider needs to analyze the tradeoff between investing in capacity (number of channels and satisfying the targeted service level to the users (probability of finding an available channel. The objective of this paper is to model this tradeoff by means of queueing theory. The methodology involves basically three steps: (i analyze user arrival (calling and service (attending processes in chosen periods, (ii select an appropriate queueing model under some simplifying assumptions, and (iii generate tradeoff curves among system performance measures, in particular, between the probability of finding an available channel and the number of channels or the mean user arrival rate. To illustrate the application of this methodology, some results deriving from a case study performed in an access provider of São Paulo state, with Poisson arrival process but non-exponential service times, are presented. Some perspectives for future research are pointed out, such as grouping users into different classes as a function of their arrival and service behavior, and analyzing capacity partitioning as a function of these classes.

  18. Hadamard quantum broadcast channels

    Science.gov (United States)

    Wang, Qingle; Das, Siddhartha; Wilde, Mark M.

    2017-10-01

    We consider three different communication tasks for quantum broadcast channels, and we determine the capacity region of a Hadamard broadcast channel for these various tasks. We define a Hadamard broadcast channel to be such that the channel from the sender to one of the receivers is entanglement-breaking and the channel from the sender to the other receiver is complementary to this one. As such, this channel is a quantum generalization of a degraded broadcast channel, which is well known in classical information theory. The first communication task we consider is classical communication to both receivers, the second is quantum communication to the stronger receiver and classical communication to other, and the third is entanglement-assisted classical communication to the stronger receiver and unassisted classical communication to the other. The structure of a Hadamard broadcast channel plays a critical role in our analysis: The channel to the weaker receiver can be simulated by performing a measurement channel on the stronger receiver's system, followed by a preparation channel. As such, we can incorporate the classical output of the measurement channel as an auxiliary variable and solve all three of the above capacities for Hadamard broadcast channels, in this way avoiding known difficulties associated with quantum auxiliary variables.

  19. Diversity Performance Analysis on Multiple HAP Networks

    Directory of Open Access Journals (Sweden)

    Feihong Dong

    2015-06-01

    Full Text Available One of the main design challenges in wireless sensor networks (WSNs is achieving a high-data-rate transmission for individual sensor devices. The high altitude platform (HAP is an important communication relay platform for WSNs and next-generation wireless networks. Multiple-input multiple-output (MIMO techniques provide the diversity and multiplexing gain, which can improve the network performance effectively. In this paper, a virtual MIMO (V-MIMO model is proposed by networking multiple HAPs with the concept of multiple assets in view (MAV. In a shadowed Rician fading channel, the diversity performance is investigated. The probability density function (PDF and cumulative distribution function (CDF of the received signal-to-noise ratio (SNR are derived. In addition, the average symbol error rate (ASER with BPSK and QPSK is given for the V-MIMO model. The system capacity is studied for both perfect channel state information (CSI and unknown CSI individually. The ergodic capacity with various SNR and Rician factors for different network configurations is also analyzed. The simulation results validate the effectiveness of the performance analysis. It is shown that the performance of the HAPs network in WSNs can be significantly improved by utilizing the MAV to achieve overlapping coverage, with the help of the V-MIMO techniques.

  20. USACE Navigation Channels 2012

    Data.gov (United States)

    California Department of Resources — This dataset represents both San Francisco and Los Angeles District navigation channel lines. All San Francisco District channel lines were digitized from CAD files...

  1. Calcium channel blocker overdose

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/002580.htm Calcium-channel blocker overdose To use the sharing features on this page, please enable JavaScript. Calcium-channel blockers are a type of medicine used to ...

  2. Performance Analysis of Amplify-and-Forward Two-Way Relaying with Co-Channel Interference and Channel Estimation Error

    KAUST Repository

    Liang Yang,

    2013-06-01

    In this paper, we consider the performance of a two-way amplify-and-forward relaying network (AF TWRN) in the presence of unequal power co-channel interferers (CCI). Specifically, we first consider AF TWRN with an interference-limited relay and two noisy-nodes with channel estimation errors and CCI. We derive the approximate signal-to-interference plus noise ratio expressions and then use them to evaluate the outage probability, error probability, and achievable rate. Subsequently, to investigate the joint effects of the channel estimation error and CCI on the system performance, we extend our analysis to a multiple-relay network and derive several asymptotic performance expressions. For comparison purposes, we also provide the analysis for the relay selection scheme under the total power constraint at the relays. For AF TWRN with channel estimation error and CCI, numerical results show that the performance of the relay selection scheme is not always better than that of the all-relay participating case. In particular, the relay selection scheme can improve the system performance in the case of high power levels at the sources and small powers at the relays.

  3. Characterization of encapsulated quantum dots via electron channeling contrast imaging

    Science.gov (United States)

    Deitz, Julia I.; Carnevale, Santino D.; De Graef, Marc; McComb, David W.; Grassman, Tyler J.

    2016-08-01

    A method for characterization of encapsulated epitaxial quantum dots (QD) in plan-view geometry using electron channeling contrast imaging (ECCI) is presented. The efficacy of the method, which requires minimal sample preparation, is demonstrated with proof-of-concept data from encapsulated (sub-surface) epitaxial InAs QDs within a GaAs matrix. Imaging of the QDs under multiple diffraction conditions is presented, establishing that ECCI can provide effectively identical visualization capabilities as conventional two-beam transmission electron microscopy. This method facilitates rapid, non-destructive characterization of sub-surface QDs giving immediate access to valuable nanostructural information.

  4. Characterization of encapsulated quantum dots via electron channeling contrast imaging

    Energy Technology Data Exchange (ETDEWEB)

    Deitz, Julia I.; McComb, David W. [Department of Materials Science and Engineering, The Ohio State University, Columbus, Ohio 43210 (United States); Carnevale, Santino D. [Department of Electrical and Computer Engineering, The Ohio State University, Columbus, Ohio 43210 (United States); De Graef, Marc [Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213 (United States); Grassman, Tyler J., E-mail: grassman.5@osu.edu [Department of Materials Science and Engineering, The Ohio State University, Columbus, Ohio 43210 (United States); Department of Electrical and Computer Engineering, The Ohio State University, Columbus, Ohio 43210 (United States)

    2016-08-08

    A method for characterization of encapsulated epitaxial quantum dots (QD) in plan-view geometry using electron channeling contrast imaging (ECCI) is presented. The efficacy of the method, which requires minimal sample preparation, is demonstrated with proof-of-concept data from encapsulated (sub-surface) epitaxial InAs QDs within a GaAs matrix. Imaging of the QDs under multiple diffraction conditions is presented, establishing that ECCI can provide effectively identical visualization capabilities as conventional two-beam transmission electron microscopy. This method facilitates rapid, non-destructive characterization of sub-surface QDs giving immediate access to valuable nanostructural information.

  5. Parametric spherical wave multiple-input and multiple-output model for ray-based simulations

    Science.gov (United States)

    Molina-Garcia-Pardo, Jose-Maria; Rodriguez, Jose-Victor; Juan-Llacer, Leandro

    2007-04-01

    In this paper, a three-dimensional parametric spherical wave model is presented that constructs the multiple-input and multiple-output (MIMO) channel from a single single-input and single-output realization of a ray-based simulator. This model assumes that rays do not change in the vicinity of the arrays. It uses spherical propagation and image theory to construct the MIMO channel for any array configuration. The main novelty of this model is that it takes into account multiple reflections, diffraction, variations in the reflection coefficient for single-bounce rays, and variations in the diffraction coefficient. Reflection is shown to be sensitive for hard polarization at the Brewster angle, though these rays have very low energy. Diffraction must be considered at the shadow boundaries of the diffraction wedge and assuming a constant diffraction coefficient, leads to inaccurate results at these regions. It is shown that in outdoor environments and for long distances, this model and the planar wave model provide similar results. However, at short distances, the parametric spherical wave model yields more accurate MIMO channels. Finally, the model is compared to some measurements in an outdoor environment.

  6. The MISO wiretap channel with channel uncertainty: Asymptotic perspectives

    KAUST Repository

    Chaaban, Anas

    2017-05-12

    The N-antenna MISO Gaussian wiretap channel with imperfect channel-state information at the transmitter (CSIT) is studied in terms of secrecy rate scaling versus the signal-to-noise ratio (SNR) and N. Two schemes are considered, beamforming (BF) and artificial noise injection (AN). It is shown that if the CSIT error is independent of SNR, then both schemes do not achieve scaling versus SNR. However, if this error vanishes as SNR increases, then AN achieves the optimal scaling versus SNR, contrary to BF. Scaling can be achieved in BF by increasing N. In fact, BF achieves the optimal scaling versus N. In the AN scheme however, injecting noise in multiple direction deteriorates its scaling versus N. Nevertheless, AN can achieve the optimal scaling if noise is sent in only one direction. This leads to better performance than BF if the CSIT error is smaller than a threshold which is also derived.

  7. Six-channel adaptive fibre-optic interferometer

    Energy Technology Data Exchange (ETDEWEB)

    Romashko, R V; Bezruk, M N; Kamshilin, A A; Kulchin, Yurii N

    2012-06-30

    We have proposed and analysed a scheme for the multiplexing of orthogonal dynamic holograms in photorefractive crystals which ensures almost zero cross talk between the holographic channels upon phase demodulation. A six-channel adaptive fibre-optic interferometer was built, and the detection limit for small phase fluctuations in the channels of the interferometer was determined to be 2.1 Multiplication-Sign 10{sup -8} rad W{sup 1/2} Hz{sup -1/2}. The channel multiplexing capacity of the interferometer was estimated. The formation of 70 channels such that their optical fields completely overlap in the crystal reduces the relative detection limit in the working channel by just 10 %. We found conditions under which the maximum cross talk between the channels was within the intrinsic noise level in the channels (-47 dB).

  8. Channel morphology [Chapter 5

    Science.gov (United States)

    Jonathan W. Long; Alvin L. Medina; Daniel G. Neary

    2012-01-01

    Channel morphology has become an increasingly important subject for analyzing the health of rivers and associated fish populations, particularly since the popularization of channel classification and assessment methods. Morphological data can help to evaluate the flows of sediment and water that influence aquatic and riparian habitat. Channel classification systems,...

  9. KV7 potassium channels

    DEFF Research Database (Denmark)

    Stott, Jennifer B; Jepps, Thomas Andrew; Greenwood, Iain A

    2014-01-01

    Potassium channels are key regulators of smooth muscle tone, with increases in activity resulting in hyperpolarisation of the cell membrane, which acts to oppose vasoconstriction. Several potassium channels exist within smooth muscle, but the KV7 family of voltage-gated potassium channels have been...

  10. A Micromechanical RF Channelizer

    Science.gov (United States)

    Akgul, Mehmet

    The power consumption of a radio generally goes as the number and strength of the RF signals it must process. In particular, a radio receiver would consume much less power if the signal presented to its electronics contained only the desired signal in a tiny percent bandwidth frequency channel, rather than the typical mix of signals containing unwanted energy outside the desired channel. Unfortunately, a lack of filters capable of selecting single channel bandwidths at RF forces the front-ends of contemporary receivers to accept unwanted signals, and thus, to operate with sub-optimal efficiency. This dissertation focuses on the degree to which capacitive-gap transduced micromechanical resonators can achieve the aforementioned RF channel-selecting filters. It aims to first show theoretically that with appropriate scaling capacitive-gap transducers are strong enough to meet the needed coupling requirements; and second, to fully detail an architecture and design procedure needed to realize said filters. Finally, this dissertation provides an actual experimentally demonstrated RF channel-select filter designed using the developed procedures and confirming theoretical predictions. Specifically, this dissertation introduces four methods that make possible the design and fabrication of RF channel-select filters. The first of these introduces a small-signal equivalent circuit for parallel-plate capacitive-gap transduced micromechanical resonators that employs negative capacitance to model the dependence of resonance frequency on electrical stiffness in a way that facilitates the analysis of micromechanical circuits loaded with arbitrary electrical impedances. The new circuit model not only correctly predicts the dependence of electrical stiffness on the impedances loading the input and output electrodes of parallel-plate capacitive-gap transduced micromechanical device, but does so in a visually intuitive way that identifies current drive as most appropriate for

  11. Performance analysis of replication ALOHA for fading mobile communications channels

    Science.gov (United States)

    Yan, Tsun-Yee; Clare, Loren P.

    1986-01-01

    This paper describes an ALOHA random access protocol for fading communications channels. A two-state Markov model is used for the channel error process to account for the channel fading memory. The ALOHA protocol is modified to send multiple contiguous copies of a message at each transmission attempt. Both pure and slotted ALOHA channels are considered. The analysis is applicable to fading environments where the channel memory is short compared to the propagation delay. It is shown that smaller delay may be achieved using replications and, in noisy conditions, can also improve throughput.

  12. Tagging of Endogenous BK Channels with a Fluorogen-Activating Peptide Reveals β4-Mediated Control of Channel Clustering in Cerebellum

    Directory of Open Access Journals (Sweden)

    Christopher P. Pratt

    2017-10-01

    Full Text Available BK channels are critical regulators of neuronal activity, controlling firing, neurotransmitter release, cerebellar function, and BK channel mutations have been linked to seizure disorders. Modulation of BK channel gating is well characterized, regulated by accessory subunit interactions, intracellular signaling pathways, and membrane potential. In contrast, the role of intracellular trafficking mechanisms in controlling BK channel function, especially in live cells, has been less studied. Fluorogen-activating peptides (FAPs are well-suited for trafficking and physiological studies due to the binding of malachite green (MG-based dyes with sub-nanomolar affinity to the FAP, resulting in bright, photostable, far-red fluorescence. Cell-excluded MG dyes enable the selective tagging of surface protein and tracking through endocytic pathways. We used CRISPR to insert the FAP at the extracellular N-terminus of BKα in the first exon of its native locus, enabling regulation by the native promoter elements and tag incorporation into multiple splice isoforms. Motor coordination was found to be normal; however, BK channel expression seems to be reduced in some locations. Alternate start site selection or post-translational proteolytic processing resulted in incomplete FAP tagging of the BKα proteins in brain tissues. In Purkinje cell somata, FAP revealed BK channel clustering previously only observed by electron microscopy. Measurement of these clusters in β4+/- and β4-/- mice showed that puncta number and cluster fluorescence intensity on the soma are reduced in β4-/- knockout animals. This novel mouse line provides a versatile fluorescent platform for studying endogenous BK channels in living and fixed tissues. Future studies could apply this line to ex vivo neuronal cultures to study live-cell channel trafficking.

  13. Lidocaine reduces the transition to slow inactivation in Nav1.7 voltage-gated sodium channels

    Science.gov (United States)

    Sheets, Patrick L; Jarecki, Brian W; Cummins, Theodore R

    2011-01-01

    BACKGROUND AND PURPOSE The primary use of local anaesthetics is to prevent or relieve pain by reversibly preventing action potential propagation through the inhibition of voltage-gated sodium channels. The tetrodotoxin-sensitive voltage-gated sodium channel subtype Nav1.7, abundantly expressed in pain-sensing neurons, plays a crucial role in perception and transmission of painful stimuli and in inherited chronic pain syndromes. Understanding the interaction of lidocaine with Nav1.7 channels could provide valuable insight into the drug's action in alleviating pain in distinct patient populations. The aim of this study was to determine how lidocaine interacts with multiple inactivated conformations of Nav1.7 channels. EXPERIMENTAL APPROACH We investigated the interactions of lidocaine with wild-type Nav1.7 channels and a paroxysmal extreme pain disorder mutation (I1461T) that destabilizes fast inactivation. Whole cell patch clamp recordings were used to examine the activity of channels expressed in human embryonic kidney 293 cells. KEY RESULTS Depolarizing pulses that increased slow inactivation of Nav1.7 channels also reduced lidocaine inhibition. Lidocaine enhanced recovery of Nav1.7 channels from prolonged depolarizing pulses by decreasing slow inactivation. A paroxysmal extreme pain disorder mutation that destabilizes fast inactivation of Nav1.7 channels decreased lidocaine inhibition. CONCLUSIONS AND IMPLICATIONS Lidocaine decreased the transition of Nav1.7 channels to the slow inactivated state. The fast inactivation gate (domain III–IV linker) is important for potentiating the interaction of lidocaine with the Nav1.7 channel. PMID:21232038

  14. Turbo Processing for Joint Channel Estimation, Synchronization, and Decoding in Coded MIMO-OFDM Systems

    Directory of Open Access Journals (Sweden)

    2009-03-01

    Full Text Available This paper proposes a turbo joint channel estimation, synchronization, and decoding scheme for coded multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM systems. The effects of carrier frequency offset (CFO, sampling frequency offset (SFO, and channel impulse responses (CIRs on the received samples are analyzed and explored to develop the turbo decoding process and vector recursive least squares (RLSs algorithm for joint CIR, CFO, and SFO tracking. For burst transmission, with initial estimates derived from the preamble, the proposed scheme can operate without the need of pilot tones during the data segment. Simulation results show that the proposed turbo joint channel estimation, synchronization, and decoding scheme offers fast convergence and low mean squared error (MSE performance over quasistatic Rayleigh multipath fading channels. The proposed scheme can be used in a coded MIMO-OFDM transceiver in the presence of multipath fading, carrier frequency offset, and sampling frequency offset to provide a bit error rate (BER performance comparable to that in an ideal case of perfect synchronization and channel estimation over a wide range of SFO values.

  15. Turbo Processing for Joint Channel Estimation, Synchronization, and Decoding in Coded MIMO-OFDM Systems

    Directory of Open Access Journals (Sweden)

    Ko ChiChung

    2009-01-01

    Full Text Available This paper proposes a turbo joint channel estimation, synchronization, and decoding scheme for coded multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM systems. The effects of carrier frequency offset (CFO, sampling frequency offset (SFO, and channel impulse responses (CIRs on the received samples are analyzed and explored to develop the turbo decoding process and vector recursive least squares (RLSs algorithm for joint CIR, CFO, and SFO tracking. For burst transmission, with initial estimates derived from the preamble, the proposed scheme can operate without the need of pilot tones during the data segment. Simulation results show that the proposed turbo joint channel estimation, synchronization, and decoding scheme offers fast convergence and low mean squared error (MSE performance over quasistatic Rayleigh multipath fading channels. The proposed scheme can be used in a coded MIMO-OFDM transceiver in the presence of multipath fading, carrier frequency offset, and sampling frequency offset to provide a bit error rate (BER performance comparable to that in an ideal case of perfect synchronization and channel estimation over a wide range of SFO values.

  16. Spreading Code Assignment Strategies for MIMO-CDMA Systems Operating in Frequency-Selective Channels

    Directory of Open Access Journals (Sweden)

    Claude D'Amours

    2009-01-01

    Full Text Available Code Division Multiple Access (CDMA and multiple input multiple output- (MIMO- CDMA systems suffer from multiple access interference (MAI which limits the spectral efficiency of these systems. By making these systems more power efficient, we can increase the overall spectral efficiency. This can be achieved through the use of improved modulation and coding techniques. Conventional MIMO-CDMA systems use fixed spreading code assignments. By strategically selecting the spreading codes as a function of the data to be transmitted, we can achieve coding gain and introduce additional degrees of freedom in the decision variables at the output of the matched filters. In this paper, we examine the bit error rate performance of parity bit-selected spreading and permutation spreading under different wireless channel conditions. A suboptimal detection technique based on maximum likelihood detection is proposed for these systems operating in frequency selective channels. Simulation results demonstrate that these code assignment techniques provide an improvement in performance in terms of bit error rate (BER while providing increased spectral efficiency compared to the conventional system. Moreover, the proposed strategies are more robust to channel estimation errors as well as spatial correlation.

  17. Spreading Code Assignment Strategies for MIMO-CDMA Systems Operating in Frequency-Selective Channels

    Directory of Open Access Journals (Sweden)

    Dahmane AdelOmar

    2009-01-01

    Full Text Available Abstract Code Division Multiple Access (CDMA and multiple input multiple output- (MIMO- CDMA systems suffer from multiple access interference (MAI which limits the spectral efficiency of these systems. By making these systems more power efficient, we can increase the overall spectral efficiency. This can be achieved through the use of improved modulation and coding techniques. Conventional MIMO-CDMA systems use fixed spreading code assignments. By strategically selecting the spreading codes as a function of the data to be transmitted, we can achieve coding gain and introduce additional degrees of freedom in the decision variables at the output of the matched filters. In this paper, we examine the bit error rate performance of parity bit-selected spreading and permutation spreading under different wireless channel conditions. A suboptimal detection technique based on maximum likelihood detection is proposed for these systems operating in frequency selective channels. Simulation results demonstrate that these code assignment techniques provide an improvement in performance in terms of bit error rate (BER while providing increased spectral efficiency compared to the conventional system. Moreover, the proposed strategies are more robust to channel estimation errors as well as spatial correlation.

  18. Accurate Alignment of Plasma Channels Based on Laser Centroid Oscillations

    Energy Technology Data Exchange (ETDEWEB)

    Gonsalves, Anthony; Nakamura, Kei; Lin, Chen; Osterhoff, Jens; Shiraishi, Satomi; Schroeder, Carl; Geddes, Cameron; Toth, Csaba; Esarey, Eric; Leemans, Wim

    2011-03-23

    A technique has been developed to accurately align a laser beam through a plasma channel by minimizing the shift in laser centroid and angle at the channel outptut. If only the shift in centroid or angle is measured, then accurate alignment is provided by minimizing laser centroid motion at the channel exit as the channel properties are scanned. The improvement in alignment accuracy provided by this technique is important for minimizing electron beam pointing errors in laser plasma accelerators.

  19. Information transfer through quantum channels

    Energy Technology Data Exchange (ETDEWEB)

    Kretschmann, D.

    2007-03-12

    This PhD thesis represents work done between Aug. 2003 and Dec. 2006 in Reinhard F. Werner's quantum information theory group at Technische Universitaet Braunschweig, and Artur Ekert's Centre for Quantum Computation at the University of Cambridge. My thesis falls into the field of abstract quantum information theory. This work investigates both fundamental properties of quantum channels and their asymptotic capacities for classical as well as quantum information transfer. Stinespring's theorem is the basic structure theorem for quantum channels. It implies that every quantum channel can be represented as a unitary evolution on an enlarged system. In Ch. 3 we present a continuity theorem for Stinespring's representation: two quantum channels are similar if and only if it is possible to find unitary implementations that are likewise similar, with dimension-independent norm bounds. The continuity theorem allows to derive a formulation of the information-disturbance tradeoff in terms of quantum channels, and a continuity estimate for the no-broadcasting principle. In Ch. 4 we then apply the continuity theorem to give a strengthened no-go proof for quantum bit commitment, an important cryptographic primitive. This result also provides a natural characterization of those protocols that fall outside the standard setting of unconditional security, and thus may allow secure bit commitment. We present a new such protocol whose security relies on decoherence in the receiver's lab. Ch. 5 reviews the capacities of quantum channels for the transfer of both classical and quantum information, and investigates several variations in the notion of channel capacity. Memory effects are then investigated in detail in Ch. 6. We advertise a model which is sufficiently general to encompass all causal automata: every quantum process in which the outputs up to any given time t do not depend on the inputs at times t'>t can be represented as a concatenated memory

  20. Ion channel pharmacology.

    Science.gov (United States)

    Camerino, Diana Conte; Tricarico, Domenico; Desaphy, Jean-François

    2007-04-01

    Because ion channels are involved in many cellular processes, drugs acting on ion channels have long been used for the treatment of many diseases, especially those affecting electrically excitable tissues. The present review discusses the pharmacology of voltage-gated and neurotransmitter-gated ion channels involved in neurologic diseases, with emphasis on neurologic channelopathies. With the discovery of ion channelopathies, the therapeutic value of many basic drugs targeting ion channels has been confirmed. The understanding of the genotype-phenotype relationship has highlighted possible action mechanisms of other empirically used drugs. Moreover, other ion channels have been pinpointed as potential new drug targets. With regards to therapy of channelopathies, experimental investigations of the intimate drug-channel interactions have demonstrated that channel mutations can either increase or decrease affinity for the drug, modifying its potential therapeutic effect. Together with the discovery of channel gene polymorphisms that may affect drug pharmacodynamics, these findings highlight the need for pharmacogenetic research to allow identification of drugs with more specific effects on channel isoforms or mutants, to increase efficacy and reduce side effects. With a greater understanding of channel genetics, structure, and function, together with the identification of novel primary and secondary channelopathies, the number of ion channel drugs for neurologic channelopathies will increase substantially.

  1. A Channelization-Based DOA Estimation Method for Wideband Signals.

    Science.gov (United States)

    Guo, Rui; Zhang, Yue; Lin, Qianqiang; Chen, Zengping

    2016-07-04

    In this paper, we propose a novel direction of arrival (DOA) estimation method for wideband signals with sensor arrays. The proposed method splits the wideband array output into multiple frequency sub-channels and estimates the signal parameters using a digital channelization receiver. Based on the output sub-channels, a channelization-based incoherent signal subspace method (Channelization-ISM) and a channelization-based test of orthogonality of projected subspaces method (Channelization-TOPS) are proposed. Channelization-ISM applies narrowband signal subspace methods on each sub-channel independently. Then the arithmetic mean or geometric mean of the estimated DOAs from each sub-channel gives the final result. Channelization-TOPS measures the orthogonality between the signal and the noise subspaces of the output sub-channels to estimate DOAs. The proposed channelization-based method isolates signals in different bandwidths reasonably and improves the output SNR. It outperforms the conventional ISM and TOPS methods on estimation accuracy and dynamic range, especially in real environments. Besides, the parallel processing architecture makes it easy to implement on hardware. A wideband digital array radar (DAR) using direct wideband radio frequency (RF) digitization is presented. Experiments carried out in a microwave anechoic chamber with the wideband DAR are presented to demonstrate the performance. The results verify the effectiveness of the proposed method.

  2. A Channelization-Based DOA Estimation Method for Wideband Signals

    Science.gov (United States)

    Guo, Rui; Zhang, Yue; Lin, Qianqiang; Chen, Zengping

    2016-01-01

    In this paper, we propose a novel direction of arrival (DOA) estimation method for wideband signals with sensor arrays. The proposed method splits the wideband array output into multiple frequency sub-channels and estimates the signal parameters using a digital channelization receiver. Based on the output sub-channels, a channelization-based incoherent signal subspace method (Channelization-ISM) and a channelization-based test of orthogonality of projected subspaces method (Channelization-TOPS) are proposed. Channelization-ISM applies narrowband signal subspace methods on each sub-channel independently. Then the arithmetic mean or geometric mean of the estimated DOAs from each sub-channel gives the final result. Channelization-TOPS measures the orthogonality between the signal and the noise subspaces of the output sub-channels to estimate DOAs. The proposed channelization-based method isolates signals in different bandwidths reasonably and improves the output SNR. It outperforms the conventional ISM and TOPS methods on estimation accuracy and dynamic range, especially in real environments. Besides, the parallel processing architecture makes it easy to implement on hardware. A wideband digital array radar (DAR) using direct wideband radio frequency (RF) digitization is presented. Experiments carried out in a microwave anechoic chamber with the wideband DAR are presented to demonstrate the performance. The results verify the effectiveness of the proposed method. PMID:27384566

  3. A Channelization-Based DOA Estimation Method for Wideband Signals

    Directory of Open Access Journals (Sweden)

    Rui Guo

    2016-07-01

    Full Text Available In this paper, we propose a novel direction of arrival (DOA estimation method for wideband signals with sensor arrays. The proposed method splits the wideband array output into multiple frequency sub-channels and estimates the signal parameters using a digital channelization receiver. Based on the output sub-channels, a channelization-based incoherent signal subspace method (Channelization-ISM and a channelization-based test of orthogonality of projected subspaces method (Channelization-TOPS are proposed. Channelization-ISM applies narrowband signal subspace methods on each sub-channel independently. Then the arithmetic mean or geometric mean of the estimated DOAs from each sub-channel gives the final result. Channelization-TOPS measures the orthogonality between the signal and the noise subspaces of the output sub-channels to estimate DOAs. The proposed channelization-based method isolates signals in different bandwidths reasonably and improves the output SNR. It outperforms the conventional ISM and TOPS methods on estimation accuracy and dynamic range, especially in real environments. Besides, the parallel processing architecture makes it easy to implement on hardware. A wideband digital array radar (DAR using direct wideband radio frequency (RF digitization is presented. Experiments carried out in a microwave anechoic chamber with the wideband DAR are presented to demonstrate the performance. The results verify the effectiveness of the proposed method.

  4. An essential function of phosphatidylinositol phosphates in activation of plant shaker‐type K+ channels

    National Research Council Canada - National Science Library

    Liu, Kun; Li, Legong; Luan, Sheng

    2005-01-01

    ...‐induced activation of the rundown channel. We also identified aluminum block as a common feature of the plant shaker‐type channels and provided evidence that aluminum block of these channels may result from Al interaction with PIPs.

  5. Enhancement effects of martentoxin on glioma BK channel and BK channel (α+β1 subtypes.

    Directory of Open Access Journals (Sweden)

    Jie Tao

    Full Text Available BACKGROUND: BK channels are usually activated by membrane depolarization and cytoplasmic Ca(2+. Especially,the activity of BK channel (α+β4 can be modulated by martentoxin, a 37 residues peptide, with Ca(2+-dependent manner. gBK channel (glioma BK channel and BK channel (α+β1 possessed higher Ca(2+ sensitivity than other known BK channel subtypes. METHODOLOGY AND PRINCIPAL FINDINGS: The present study investigated the modulatory characteristics of martentoxin on these two BK channel subtypes by electrophysiological recordings, cell proliferation and Ca(2+ imaging. In the presence of cytoplasmic Ca(2+, martentoxin could enhance the activities of both gBK and BK channel (α+β1 subtypes in dose-dependent manner with EC(50 of 46.7 nM and 495 nM respectively, while not shift the steady-state activation of these channels. The enhancement ratio of martentoxin on gBK and BK channel (α+β1 was unrelated to the quantitative change of cytoplasmic Ca(2+ concentrations though the interaction between martentoxin and BK channel (α+β1 was accelerated under higher cytoplasmic Ca(2+. The selective BK pore blocker iberiotoxin could fully abolish the enhancement of these two BK subtypes induced by martentoxin, suggesting that the auxiliary β subunit might contribute to the docking for martentoxin. However, in the absence of cytoplasmic Ca(2+, the activity of gBK channel would be surprisingly inhibited by martentoxin while BK channel (α+β1 couldn't be affected by the toxin. CONCLUSIONS AND SIGNIFICANCE: Thus, the results shown here provide the novel evidence that martentoxin could increase the two Ca(2+-hypersensitive BK channel subtypes activities in a new manner and indicate that β subunit of these BK channels plays a vital role in this enhancement by martentoxin.

  6. The X3: A 200 kW Class Nested Channel Hall Thruster

    Science.gov (United States)

    Sheehan, J. P.

    2016-10-01

    Electric propulsion has seen rapid adoption in recent years for commercial, scientific, and exploratory space missions. The X3 is a three channel nested channel Hall thruster, designed to push the boundaries of high power electric propulsion for cargo transfer to Mars and large military assets. It has been operated at thermal steady state up to 30 kW of power. Thrust measurements were made on an inverted pendulum thrust stand, indicating over 2000 s specific impulse and 65 mN/kW thrust to power ratio. Detailed plume measurements were made with Faraday and Langmuir probes. The multiple concentric channels provide better performance than the sum of the individual channel operations due to superior propellant utilization from its compact design. Using a high speed camera, the breathing and spoke mode instabilities were captured in all three channels. Spoke and breathing instabilities couple between the channels, indicating that complex plasma and neutral interactions are at play. Electron transport, both cross field and in the cathode plume, are well suited to be explored in a thruster of this size. Supported under NASA contract No. NNH16CP17C.

  7. Channel-facilitated molecular transport: The role of strength and spatial distribution of interactions

    Energy Technology Data Exchange (ETDEWEB)

    Uppulury, Karthik, E-mail: karthik.uppulury@gmail.com [Department of Chemistry, Texas Tech University, Lubbock, TX 79409 (United States); Kolomeisky, Anatoly B. [Department of Chemistry, Department of Chemical and Biomolecular Engineering, Center for Theoretical Biological Physics, Rice University, Houston, TX 77005 (United States)

    2016-12-20

    Highlights: • Molecular flux strongly depends on the strength of the molecule-pore interactions. • There exists an optimal molecule-pore interaction potential for maximal flux. • Volume of interactions depends inversely on the strength for maximal flux. • Stronger interactions need more number of attractive sites for maximal flux. • Channels with few special sites need more attractive sites for higher flux. - Abstract: Molecular transport across channels and pores is critically important for multiple natural and industrial processes. Recent advances in single-molecule techniques have allowed researchers to probe translocation through nanopores with unprecedented spatial and temporal resolution. However, our understanding of the mechanisms of channel-facilitated molecular transport is still not complete. We present a theoretical approach that investigates the role of molecular interactions in the transport through channels. It is based on the discrete-state stochastic analysis that provides a fully analytical description of this complex process. It is found that a spatial distribution of the interactions strongly influences the translocation dynamics. We predict that there is the optimal distribution that leads to the maximal flux through the channel. It is also argued that the channel transport depends on the strength of the molecule-pore interactions, on the shape of interaction potentials and on the relative contributions of entrance and diffusion processes in the system. These observations are discussed using simple physical-chemical arguments.

  8. A Study on Coexistence Capability Evaluations of the Enhanced Channel Hopping Mechanism in WBANs

    Science.gov (United States)

    Wei, Zhongcheng; Sun, Yongmei; Ji, Yuefeng

    2017-01-01

    As an important coexistence technology, channel hopping can reduce the interference among Wireless Body Area Networks (WBANs). However, it simultaneously brings some issues, such as energy waste, long latency and communication interruptions, etc. In this paper, we propose an enhanced channel hopping mechanism that allows multiple WBANs coexisted in the same channel. In order to evaluate the coexistence performance, some critical metrics are designed to reflect the possibility of channel conflict. Furthermore, by taking the queuing and non-queuing behaviors into consideration, we present a set of analysis approaches to evaluate the coexistence capability. On the one hand, we present both service-dependent and service-independent analysis models to estimate the number of coexisting WBANs. On the other hand, based on the uniform distribution assumption and the additive property of Possion-stream, we put forward two approximate methods to compute the number of occupied channels. Extensive simulation results demonstrate that our estimation approaches can provide an effective solution for coexistence capability estimation. Moreover, the enhanced channel hopping mechanism can significantly improve the coexistence capability and support a larger arrival rate of WBANs. PMID:28098818

  9. A Study on Coexistence Capability Evaluations of the Enhanced Channel Hopping Mechanism in WBANs.

    Science.gov (United States)

    Wei, Zhongcheng; Sun, Yongmei; Ji, Yuefeng

    2017-01-14

    As an important coexistence technology, channel hopping can reduce the interference among Wireless Body Area Networks (WBANs). However, it simultaneously brings some issues, such as energy waste, long latency and communication interruptions, etc. In this paper, we propose an enhanced channel hopping mechanism that allows multiple WBANs coexisted in the same channel. In order to evaluate the coexistence performance, some critical metrics are designed to reflect the possibility of channel conflict. Furthermore, by taking the queuing and non-queuing behaviors into consideration, we present a set of analysis approaches to evaluate the coexistence capability. On the one hand, we present both service-dependent and service-independent analysis models to estimate the number of coexisting WBANs. On the other hand, based on the uniform distribution assumption and the additive property of Possion-stream, we put forward two approximate methods to compute the number of occupied channels. Extensive simulation results demonstrate that our estimation approaches can provide an effective solution for coexistence capability estimation. Moreover, the enhanced channel hopping mechanism can significantly improve the coexistence capability and support a larger arrival rate of WBANs.

  10. Customers’ Perception regarding Assurance of Bancassurance Channel

    Directory of Open Access Journals (Sweden)

    Choudhury Mousumi

    2016-12-01

    Full Text Available Bancassurance has evolved as a strong distribution channel in India. Bancassurance means that the insurance company and the bank come together to offer insurance products from the counter of the banks to the bank’s customer. The present study attempts to analyse customers’ perception regarding assurance of bancassurance channel in providing insurance-related services. The study also tries to find out the impact of various demographic variables on customers’ perception regarding assurance of bancassurance channel. The study finds that customers consider bancassurance channel having high assurance in providing insurance services. It is also found in the study that there is no significant association between the demographic variables considered in the study and customers’ perception regarding assurance of bancassurance channel.

  11. Performance Analysis of the 3GPP-LTE Physical Control Channels

    OpenAIRE

    S. J. Thiruvengadam; Louay M. A. Jalloul

    2010-01-01

    Maximum likelihood-based (ML) receiver structures are derived for the decoding of the downlink control channels in the new long-term evolution (LTE) standard based on multiple-input and multiple-output (MIMO) antennas and orthogonal frequency division multiplexing (OFDM). The performance of the proposed receiver structures for the physical control format indicator channel (PCFICH) and the physical hybrid-ARQ indicator channel (PHICH) is analyzed for various fading-channel models and MIMO sch...

  12. Performance Analysis of MIMO-STBC Systems with Higher Coding Rate Using Adaptive Semiblind Channel Estimation Scheme

    Directory of Open Access Journals (Sweden)

    Ravi Kumar

    2014-01-01

    Full Text Available Semiblind channel estimation method provides the best trade-off in terms of bandwidth overhead, computational complexity and latency. The result after using multiple input multiple output (MIMO systems shows higher data rate and longer transmit range without any requirement for additional bandwidth or transmit power. This paper presents the detailed analysis of diversity coding techniques using MIMO antenna systems. Different space time block codes (STBCs schemes have been explored and analyzed with the proposed higher code rate. STBCs with higher code rates have been simulated for different modulation schemes using MATLAB environment and the simulated results have been compared in the semiblind environment which shows the improvement even in highly correlated antenna arrays and is found very close to the condition when channel state information (CSI is known to the channel.

  13. Performance analysis of MIMO-STBC systems with higher coding rate using adaptive semiblind channel estimation scheme.

    Science.gov (United States)

    Kumar, Ravi; Saxena, Rajiv

    2014-01-01

    Semiblind channel estimation method provides the best trade-off in terms of bandwidth overhead, computational complexity and latency. The result after using multiple input multiple output (MIMO) systems shows higher data rate and longer transmit range without any requirement for additional bandwidth or transmit power. This paper presents the detailed analysis of diversity coding techniques using MIMO antenna systems. Different space time block codes (STBCs) schemes have been explored and analyzed with the proposed higher code rate. STBCs with higher code rates have been simulated for different modulation schemes using MATLAB environment and the simulated results have been compared in the semiblind environment which shows the improvement even in highly correlated antenna arrays and is found very close to the condition when channel state information (CSI) is known to the channel.

  14. Small Terminal MIMO Channels with User Interaction

    DEFF Research Database (Denmark)

    Pedersen, Gert Frølund; Andersen, Jørgen Bach; Eggers, Patrick Claus F.

    2007-01-01

    This paper gives an overview of results obtained from measurements of different types of multiple-input multiple-output (MIMO) channels. For the indoor case measurements were made at 5.8 GHz from access points (APs) to mobile stations (MSs) at different places in a large open office type room. Th...... an investigation of the potentials for communication between cars approaching as well as in convoy and from inside and outside the car....

  15. Optimum Cyclic Redundancy Codes for Noisy Channels

    Science.gov (United States)

    Posner, E. C.; Merkey, P.

    1986-01-01

    Capabilities and limitations of cyclic redundancy codes (CRC's) for detecting transmission errors in data sent over relatively noisy channels (e.g., voice-grade telephone lines or very-high-density storage media) discussed in 16-page report. Due to prevalent use of bytes in multiples of 8 bits data transmission, report primarily concerned with cases in which both block length and number of redundant bits (check bits for use in error detection) included in each block are multiples of 8 bits.

  16. Sea Anemone Toxins Affecting Potassium Channels

    Science.gov (United States)

    Diochot, Sylvie; Lazdunski, Michel

    The great diversity of K+ channels and their wide distribution in many tissues are associated with important functions in cardiac and neuronal excitability that are now better understood thanks to the discovery of animal toxins. During the past few decades, sea anemones have provided a variety of toxins acting on voltage-sensitive sodium and, more recently, potassium channels. Currently there are three major structural groups of sea anemone K+ channel (SAK) toxins that have been characterized. Radioligand binding and electrophysiological experiments revealed that each group contains peptides displaying selective activities for different subfamilies of K+ channels. Short (35-37 amino acids) peptides in the group I display pore blocking effects on Kv1 channels. Molecular interactions of SAK-I toxins, important for activity and binding on Kv1 channels, implicate a spot of three conserved amino acid residues (Ser, Lys, Tyr) surrounded by other less conserved residues. Long (58-59 amino acids) SAK-II peptides display both enzymatic and K+ channel inhibitory activities. Medium size (42-43 amino acid) SAK-III peptides are gating modifiers which interact either with cardiac HERG or Kv3 channels by altering their voltage-dependent properties. SAK-III toxins bind to the S3C region in the outer vestibule of Kv channels. Sea anemones have proven to be a rich source of pharmacological tools, and some of the SAK toxins are now useful drugs for the diagnosis and treatment of autoimmune diseases.

  17. A comparison of single-channel linear amplification and two-channel wide-dynamic-range-compression amplification by means of an independent-group design.

    Science.gov (United States)

    Humes, Larry E; Humes, Lauren E; Wilson, Dana L

    2004-06-01

    The present study used an independent-group design to compare the benefits provided by binaural, single-channel, linear, full-shell in-the-ear hearing aids and binaural, 2-channel, wide-dynamic-range-compression in-the-canal hearing aids in groups of older hearing aid wearers. Hearing aid outcome measures were obtained at both 1-month (n = 53) and 6-month (n = 34) postfit intervals with each device. Outcome measures included multiple measures of speech-recognition performance and self-report measures of hearing aid benefit, satisfaction, and usage. Aided sound-quality measurements were also obtained. Although both devices provided significant benefits to the wearers, there were no significant differences in the benefits provided by either device at the 1-month or 6-month postfit intervals.

  18. Dynamic Digital Channelizer Based on Spectrum Sensing.

    Science.gov (United States)

    Hu, Junpeng; Zuo, Zhen; Huang, Zhiping; Dong, Zhi

    2015-01-01

    The ability to efficiently channelize a received signal with dynamic sub-channel bandwidths is a key requirement of software defined radio (SDR) systems. The digital channelizer, which is used to split the received signal into a number of sub-channels, plays an important role in SDR systems. In this paper, a design of dynamic digital channelizer is presented. The proposed method is novel in that it employs a cosine modulated filter bank (CMFB) to divide the received signal into multiple frequency sub-bands and a spectrum sensing technique, which is mostly used in cognitive radio, is introduced to detect the presence of signal of each sub-band. The method of spectrum sensing is carried out based on the eigenvalues of covariance matrix of received signal. The ratio of maximum-minimum eigenvalue of each sub-band is vulnerable to noise fluctuation. This paper suggests an optimized method to calculate the ratio of maximum-minimum eigenvalue. The simulation results imply that the design of digital channelizer can effectively separate the received signal with dynamically changeable sub-channel signals.

  19. Sensitivity Analysis of Aerosol Retrieval Algorithms Using Two-Channel Satellite Radiance Data

    Science.gov (United States)

    Geogdzhayev, Igor V.; Mishchenko, Michael I.

    1999-01-01

    We discuss the methodology of interpreting channel 1 and 2 AVHRR radiance data to retrieve tropospheric aerosol properties over the ocean and describe a detailed analysis of the sensitivity of monthly average retrievals to the assumed aerosol models. We use real AVHRR data and accurate numerical techniques for computing single and multiple scattering and spectral absorption of light in the vertically inhomogeneous atmosphere-ocean system. Our analysis shows that two-channel algorithms can provide significantly more accurate retrievals of the aerosol optical thickness than one-channel algorithms and that imperfect cloud screening is the largest source of errors in the retrieved optical thickness. Both underestimating and overestimating aerosol absorption as well as strong variability of the aerosol refractive index may lead to regional and/or seasonal biases in optical thickness retrievals. The Angstrom exponent appears to be the most invariant aerosol size characteristic and should be retrieved along with optical thickness as the second aerosol parameter.

  20. Channel Modelling for Multiprobe Over-the-Air MIMO Testing

    Directory of Open Access Journals (Sweden)

    Pekka Kyösti

    2012-01-01

    a fading emulator, an anechoic chamber, and multiple probes. Creation of a propagation environment inside an anechoic chamber requires unconventional radio channel modelling, namely, a specific mapping of the original models onto the probe antennas. We introduce two novel methods to generate fading emulator channel coefficients; the prefaded signals synthesis and the plane wave synthesis. To verify both methods we present a set of simulation results. We also show that the geometric description is a prerequisite for the original channel model.

  1. Joint compensation of multiple RF impairments in MIMO STBC systems

    KAUST Repository

    Qi, Jian

    2011-09-01

    In this paper, we propose a compensation method for the joint effect of high-power amplifier (HPA) nonlinearity, in-phase/quadrature-phase (I/Q) imbalance and crosstalk in multiple-input multiple-output (MIMO) orthogonal space-time block coding (OSTBC) systems. The performance of the MIMO OSTBC equipped with the proposed compensation mechanism is evaluated in terms of average symbol error probability and system capacity, in Rayleigh fading channels. Numerical results are provided and show the effects on performance of several system parameters, namely, the HPA parameters, image-leakage ratio, crosstalk, numbers of antennas, and phase-shift keying modulation order. © 2011 IEEE.

  2. Transcriptome Analysis of the Central and Peripheral Nervous Systems of the Spider Cupiennius salei Reveals Multiple Putative Cys-Loop Ligand Gated Ion Channel Subunits and an Acetylcholine Binding Protein.

    Directory of Open Access Journals (Sweden)

    Päivi H Torkkeli

    Full Text Available Invertebrates possess a diverse collection of pentameric Cys-loop ligand gated ion channel (LGIC receptors whose molecular structures, evolution and relationships to mammalian counterparts have been intensely investigated in several clinically and agriculturally important species. These receptors are targets for a variety of control agents that may also harm beneficial species. However, little is known about Cys-loop receptors in spiders, which are important natural predators of insects. We assembled de novo transcriptomes from the central and peripheral nervous systems of the Central American wandering spider Cupiennius salei, a model species for neurophysiological, behavioral and developmental studies. We found 15 Cys-loop receptor subunits that are expected to form anion or cation permeable channels, plus a putative acetylcholine binding protein (AChBP that has only previously been reported in molluscs and one annelid. We used phylogenetic and sequence analysis to compare the spider subunits to homologous receptors in other species and predicted the 3D structures of each protein using the I-Tasser server. The quality of homology models improved with increasing sequence identity to the available high-resolution templates. We found that C. salei has orthologous γ-aminobutyric acid (GABA, GluCl, pHCl, HisCl and nAChα LGIC subunits to other arthropods, but some subgroups are specific to arachnids, or only to spiders. C. salei sequences were phylogenetically closest to gene fragments from the social spider, Stegodyphus mimosarum, indicating high conservation within the Araneomorphae suborder of spiders. C. salei sequences had similar ligand binding and transmembrane regions to other invertebrate and vertebrate LGICs. They also had motifs associated with high sensitivity to insecticides and antiparasitic agents such as fipronil, dieldrin and ivermectin. Development of truly selective control agents for pest species will require information about

  3. Fuel cell collector plates with improved mass transfer channels

    Science.gov (United States)

    Gurau, Vladimir; Barbir, Frano; Neutzler, Jay K.

    2003-04-22

    A fuel cell collector plate can be provided with one or more various channel constructions for the transport of reactants to the gas diffusion layer and the removal of water therefrom. The outlet channel can be arranged to have a reduced volume compared to the inlet channel, in both interdigitated and discontinuous spiral applications. The land width between an inlet channel and outlet channel can be reduced to improved mass flow rate in regions of deleted reactant concentrations. Additionally or alternatively, the depth of the inlet channel can be reduced in the direction of flow to reduce the diffusion path as the concentration of reactant is reduced.

  4. Radio Channel Modelling Using Stochastic Propagation Graphs

    DEFF Research Database (Denmark)

    Pedersen, Troels; Fleury, Bernard Henri

    2007-01-01

    In this contribution the radio channel model proposed in [1] is extended to include multiple transmitters and receivers. The propagation environment is modelled using random graphs where vertices of a graph represent scatterers and edges model the wave propagation between scatterers. Furthermore...

  5. Manufacturing Advanced Channel Wall Rocket Liners Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR will adapt and demonstrate a low cost flexible method of manufacturing channel wall liquid rocket nozzles and combustors, while providing developers a...

  6. The Neural Noisy Channel

    OpenAIRE

    Yu, Lei; Blunsom, Phil; Dyer, Chris; Grefenstette, Edward; Kocisky, Tomas

    2016-01-01

    We formulate sequence to sequence transduction as a noisy channel decoding problem and use recurrent neural networks to parameterise the source and channel models. Unlike direct models which can suffer from explaining-away effects during training, noisy channel models must produce outputs that explain their inputs, and their component models can be trained with not only paired training samples but also unpaired samples from the marginal output distribution. Using a latent variable to control ...

  7. A simple quantum channel having superadditivity of channel capacity

    OpenAIRE

    Sasaki, Masahide; Kato, Kentaro; Izutsu, Masayuki; Hirota, Osamu

    1997-01-01

    When classical information is sent through a quantum channel of nonorthogonal states, there is a possibility that transmittable classical information exceeds a channel capacity in a single use of the initial channel by extending it into multi-product channel. In this paper, it is shown that this remarkable feature of a quantum channel, so-called superadditivity, appears even in as low as the third extended coding of the simplest binary input channel. A physical implementation of this channel ...

  8. On the low SNR capacity of MIMO fading channels with imperfect channel state information

    KAUST Repository

    Benkhelifa, Fatma

    2014-05-01

    The capacity of Multiple Input Multiple Output (MIMO) Rayleigh fading channels with full knowledge of channel state information (CSI) at both the transmitter and the receiver (CSI-TR) has been shown recently to scale at low Signal-to-Noise Ratio (SNR) essentially as SNR log(1=SNR), independently of the number of transmit and receive antennas. In this paper, we investigate the ergodic capacity of MIMO Rayleigh fading channel with estimated channel state information at the transmitter (CSI-T) and possibly imperfect channel state information at the receiver (CSI-R). Our framework can be seen as a generalization of previous works as it can capture the perfect CSI-TR as a special case when the estimation error variance goes to zero. In our work, we mainly focus on the low SNR regime and we show that the capacity scales as (1-α) SNR log(1=SNR), where α is the estimation error variance. This characterization shows the loss of performance due to error estimation over the perfect channel state information at both the transmitter and the receiver. As a by-product of our new analysis, we show that our framework can also be extended to characterize the capacity of MIMO Rician fading channels at low SNR with possibly imperfect CSI-T and CSI-R. © 2014 IFIP.

  9. On the low SNR capacity of MIMO fading channels with imperfect channel state information

    KAUST Repository

    Benkhelifa, Fatma

    2014-06-01

    The capacity of multiple-input multiple-output (MIMO) Rayleigh fading channels with full knowledge of channel state information (CSI) at both the transmitter and the receiver (CSI-TR) has been shown recently to scale at low signal-to-noise ratio (SNR) essentially as SNR log(1/SNR), independently of the number of transmit and receive antennas. In this paper, we investigate the ergodic capacity of MIMO Rayleigh fading channel with estimated channel state information at the transmitter (CSI-T) and possibly imperfect channel state information at the receiver (CSI-R). Our framework can be seen as a generalization of previous works as it can capture the perfect CSI-TR as a special case when the estimation error variance goes to zero. In this paper, we mainly focus on the low SNR regime, and we show that the capacity scales as (1-α) SNR log(1/SNR), where α is the estimation error variance. This characterization shows the loss of performance due to error estimation over the perfect channel state information at both the transmitter and the receiver. As a by-product of our new analysis, we show that our framework can be also extended to characterize the capacity of MIMO Rician fading channels at low SNR with possibly imperfect CSI-T and CSI-R. © 1972-2012 IEEE.

  10. Excitability constraints on voltage-gated sodium channels.

    Directory of Open Access Journals (Sweden)

    Elaine Angelino

    2007-09-01

    Full Text Available We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathematical models have suggested that sodium channel properties need to be tightly constrained for an action potential to propagate. There are nine mammalian genes encoding voltage-gated sodium channels, many of which are more than approximately 90% identical by sequence. This sequence similarity presumably corresponds to similarity of function, consistent with the idea that these properties must be tightly constrained. However, the multiplicity of genes encoding sodium channels raises the question: why are there so many? We demonstrate that the simplest theoretical constraints bounding sodium channel diversity--the requirements of membrane excitability and the uniqueness of the resting potential--act directly on constraining sodium channel properties. We compare the predicted constraints with functional data on mammalian sodium channel properties collected from the literature, including 172 different sets of measurements from 40 publications, wild-type and mutant, under a variety of conditions. The data from all channel types, including mutants, obeys the excitability constraint; on the other hand, channels expressed in muscle tend to obey the constraint of a unique resting potential, while channels expressed in neuronal tissue do not. The excitability properties alone distinguish the nine sodium channels into four different groups that are consistent with phylogenetic analysis. Our calculations suggest interpretations for the functional differences between these groups.

  11. Neutron Multiplicity Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Frame, Katherine Chiyoko [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-06-28

    Neutron multiplicity measurements are widely used for nondestructive assay (NDA) of special nuclear material (SNM). When combined with isotopic composition information, neutron multiplicity analysis can be used to estimate the spontaneous fission rate and leakage multiplication of SNM. When combined with isotopic information, the total mass of fissile material can also be determined. This presentation provides an overview of this technique.

  12. TRP channels in schistosomes

    Directory of Open Access Journals (Sweden)

    Swarna Bais

    2016-12-01

    Full Text Available Praziquantel (PZQ is effectively the only drug currently available for treatment and control of schistosomiasis, a disease affecting hundreds of millions of people worldwide. Many anthelmintics, likely including PZQ, target ion channels, membrane protein complexes essential for normal functioning of the neuromusculature and other tissues. Despite this fact, only a few classes of parasitic helminth ion channels have been assessed for their pharmacological properties or for their roles in parasite physiology. One such overlooked group of ion channels is the transient receptor potential (TRP channel superfamily. TRP channels share a common core structure, but are widely diverse in their activation mechanisms and ion selectivity. They are critical to transducing sensory signals, responding to a wide range of external stimuli. They are also involved in other functions, such as regulating intracellular calcium and organellar ion homeostasis and trafficking. Here, we review current literature on parasitic helminth TRP channels, focusing on those in schistosomes. We discuss the likely roles of these channels in sensory and locomotor activity, including the possible significance of a class of TRP channels (TRPV that is absent in schistosomes. We also focus on evidence indicating that at least one schistosome TRP channel (SmTRPA has atypical, TRPV1-like pharmacological sensitivities that could potentially be exploited for future therapeutic targeting.

  13. Computation of gradually varied flow in compound open channel ...

    Indian Academy of Sciences (India)

    In this method, the energy and continuity equations are solved for steady, gradually varied flow by the Newton–Raphson method and the proposed methodology is applied to tree-type and looped-channel networks. An algorithm is presented to determine multiple critical depths in a compound channel. Modifications in ...

  14. Manipulating riparian vegetation, large wood, and discharge in a gravel-cobble bed stream: channel response

    Science.gov (United States)

    McDowell, P. F.

    2016-12-01

    The Middle Fork John Day River at Oxbow Conservation Area, northeastern Oregon, experienced heavy cattle grazing for a number of decades and was dredge mined for gold in the 1930s-50s. As a result of dredging, flow was divided between the original meandering channel on the southern part of the floodplain and a straight dredged channel on the northern part of the floodplain. The Confederated Tribes of the Warm Springs acquired this property and began planning floodplain and instream restoration focused primarily on anadromous and resident salmonids. In 2000, cattle grazing in the riparian zone was eliminated, resulting in expansion of sedges and other plants on banks, bars and the channel bed. In 2003, riparian planting of woody vegetation began. In 2011, log structures were constructed in the south channel. The overarching goals of the log structure project were: 1) to add bank protection and roughness to accommodate the planned increase in discharge, and 2) to provide fish cover, pools, and channel complexity. In 2013, the north channel was closed and all flow was put in the south channel. This paper examines channel morphological response to these multiple actions. Channel adjustment was monitored through repeated channel cross-section surveys, longitudinal profile surveys, and analysis of planform change using high-resolution aerial imagery. I hypothesized that channel adjustment would be greatest where banks were less protected, and where bed materials were more mobile due to smaller size or local hydraulic factors such as bend curvature. The results indicate that there has been significant reorganization of riffle-pool structure in the longitudinal profile, but less change in cross-sections and planform. Cross-sections, both at log structures and not at structures, show limited bar aggradation and bank erosion. Some modest erosion occurred on banks protected by log structures. There is no increase in pool depth. The hypothesized relationship between channel

  15. Distributed Space-Time Block Coded Transmission with Imperfect Channel Estimation: Achievable Rate and Power Allocation

    Directory of Open Access Journals (Sweden)

    Sonia Aïssa

    2008-05-01

    Full Text Available This paper investigates the effects of channel estimation error at the receiver on the achievable rate of distributed space-time block coded transmission. We consider that multiple transmitters cooperate to send the signal to the receiver and derive lower and upper bounds on the mutual information of distributed space-time block codes (D-STBCs when the channel gains and channel estimation error variances pertaining to different transmitter-receiver links are unequal. Then, assessing the gap between these two bounds, we provide a limiting value that upper bounds the latter at any input transmit powers, and also show that the gap is minimum if the receiver can estimate the channels of different transmitters with the same accuracy. We further investigate positioning the receiving node such that the mutual information bounds of D-STBCs and their robustness to the variations of the subchannel gains are maximum, as long as the summation of these gains is constant. Furthermore, we derive the optimum power transmission strategy to achieve the outage capacity lower bound of D-STBCs under arbitrary numbers of transmit and receive antennas, and provide closed-form expressions for this capacity metric. Numerical simulations are conducted to corroborate our analysis and quantify the effects of imperfect channel estimation.

  16. Interference-aware power control for multi-radio multi-channel wireless mesh networks

    CSIR Research Space (South Africa)

    Olwal, TO

    2009-09-01

    Full Text Available radio has a single or multiple orthogonal channels. In this scenario, an MP node has each radio with its own medium access control (MAC) and physical layers [1]. This implies an independent communications in these radios. Thus, a single MP node can... with a reduced complexity whereby each NIC autonomously and locally predicts interference of multiple channels. Moreover, each NIC has independent amount of traffic load at its queue and independent dimension of multiple channel states to estimate...

  17. Modulation of the frequency response of Shaker potassium channels by the quiver peptide suggesting a novel extracellular interaction mechanism.

    Science.gov (United States)

    Wang, Jing W; Wu, Chun-Fang

    2010-07-01

    Recent studies have indicated that the Shaker potassium channel regulates sleep in Drosophila. The Drosophila quiver (qvr) gene encodes a novel potassium channel subunit that modulates the Shaker potassium channel. The Qvr peptide contains a signal sequence for extracellular localization and may regulate a unique feature of the Shaker I(A) current that confers special neuronal excitability patterns. Thus, studies of the Shaker channel properties in the qvr mutant background should provide an opportunity to uncover a new form of physiologic modulation of potassium channels. We have begun to investigate the impact of qvr protein on the Shaker channel properties and its implications in synaptic function in vivo. We studied synaptic transmission at the larval neuromuscular junction and characterized the transient potassium current I(A) in larval muscles. We identified two different functional states of I(A) in qvr larval muscles, as reflected by two distinct components, I(AF) and I(AS), differing in their kinetics of recovery from inactivation and sensitivity to a K(+) channel blocker. Correspondingly, qvr mutant larvae exhibit multiple synaptic discharges following individual nerve stimuli during repetitive activity.

  18. Parenting Multiples

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Parenting Multiples KidsHealth / For Parents / Parenting Multiples What's in ... your ability to take care of your babies. Parenting Issues With Multiples It may be difficult to ...

  19. Modelling customer behaviour in multi-channel service distribution

    NARCIS (Netherlands)

    Heinhuis, D.; de Vries, E.J.; Kundisch, D.; Veit, D.J.; Weitzel, T.; Weinhardt, C.

    2009-01-01

    Financial service providers are innovating their distribution strategy into multi-channel strategies. The success of a multi-channel approach and the high investments made in information systems and enterprise architectures depends on the adoption and multi-channel usage behaviour of consumers. We

  20. The Channels of Monetary Transmission: Lessons for Monetary Policy

    OpenAIRE

    Mishkin, Frederic S.

    1996-01-01

    This paper provides an overview of the transmission mechanisms of monetary policy, starting with traditional interest rate channels, going on to channels operating through other asset prices, and then on to the so-called credit channels. The paper then discusses the implications from this literature for how central banks might best conduct monetary policy.

  1. Microwave Radiometer – 3 Channel (MWR3C) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Cadeddu, MP

    2012-05-04

    The microwave radiometer 3-channel (MWR3C) provides time-series measurements of brightness temperatures from three channels centered at 23.834, 30, and 89 GHz. These three channels are sensitive to the presence of liquid water and precipitable water vapor.

  2. Serial data transmission between redundant channels

    Science.gov (United States)

    Tulpule, Bhalchandra R. (Inventor); Binnall, Daniel G. (Inventor)

    1992-01-01

    Data is communicated between redundant channels formatted in blocks having an initial command word followed by a destination code, starting address and a variable number of data words including a word count. The blocks are transmitted between each channel and all of the channels over cross-channel data links, each channel receiving the data blocks and determining the validity thereof by counting the number of data words received and comparing that number to the word count transmitted for that block. An interrupt signal indicative of invalidity of a block is provided in the event of a miscompare. A stop address is generated for each block received for storage at the start address. A memory address is generated for each valid word received for storage in sequence starting immediately after the start address. The next block received has its start address placed immediately at the end of the previously received block.

  3. Research on Cost Information Sharing and Channel Choice in a Dual-Channel Supply Chain

    Directory of Open Access Journals (Sweden)

    Huihui Liu

    2016-01-01

    Full Text Available Many studies examine information sharing in an uncertain demand environment in a supply chain. However there is little literature on cost information sharing in a dual-channel structure consisting of a retail channel and a direct sales channel. Assuming that the retail sale cost and direct sale cost are random variables with a general distribution, the paper investigates the retailer’s choice on cost information sharing in a Bertrand competition model. Based on the equilibrium outcome of information sharing, the manufacturer’s channel choice is discussed in detail. Our paper provides several interesting conclusions. In both single- and dual-channel structures, the retailer has little motivation to share its private cost information which is verified to be valuable for the manufacturer. When the cost correlation between the two channels increases, our analyses show that the manufacturer’s profit improves. However, when channel choice is involved, the value of information could play a different role. The paper finds that a dual-channel structure can benefit the manufacturer only when the cost correlation is sufficiently low. In addition, if the cost correlation is weak, the cost fluctuation will bring out the advantage of a dual-channel structure and adding a new direct channel will help in risk pooling.

  4. Alternating Rate Profile Optimization in Single Stream MIMO Interference Channels

    OpenAIRE

    Mochaourab, Rami; Cao, Pan; Jorswieck, Eduard

    2013-01-01

    The multiple-input multiple-output interference channel is considered with perfect channel information at the transmitters and single-user decoding receivers. With all transmissions restricted to single stream beamforming, we consider the problem of finding all Pareto optimal rate-tuples in the achievable rate region. The problem is cast as a rate profile optimization problem. Due to its nonconvexity, we resort to an alternating approach: For fixed receivers, optimal transmission is known. Fo...

  5. The multiparty coherent channel and its implementation with linear optics.

    Science.gov (United States)

    He, Guangqiang; Liu, Taizhi; Tao, Xin

    2013-08-26

    The continuous-variable coherent (conat) channel is a useful resource for coherent communication, supporting coherent teleportation and coherent superdense coding. We extend the conat channel to multiparty conditions by proposing definitions on multiparty position-quadrature and momentum-quadrature conat channel. We additionally provide two methods to implement this channel using linear optics. One method is the multiparty version of coherent communication assisted by entanglement and classical communication (CCAECC). The other is multiparty coherent superdense coding.

  6. Hysteresis in voltage-gated channels.

    Science.gov (United States)

    Villalba-Galea, Carlos A

    2017-03-04

    Ion channels constitute a superfamily of membrane proteins found in all living creatures. Their activity allows fast translocation of ions across the plasma membrane down the ion's transmembrane electrochemical gradient, resulting in a difference in electrical potential across the plasma membrane, known as the membrane potential. A group within this superfamily, namely voltage-gated channels, displays activity that is sensitive to the membrane potential. The activity of voltage-gated channels is controlled by the membrane potential, while the membrane potential is changed by these channels' activity. This interplay produces variations in the membrane potential that have evolved into electrical signals in many organisms. These signals are essential for numerous biological processes, including neuronal activity, insulin release, muscle contraction, fertilization and many others. In recent years, the activity of the voltage-gated channels has been observed not to follow a simple relationship with the membrane potential. Instead, it has been shown that the activity of voltage-gated channel displays hysteresis. In fact, a growing number of evidence have demonstrated that the voltage dependence of channel activity is dynamically modulated by activity itself. In spite of the great impact that this property can have on electrical signaling, hysteresis in voltage-gated channels is often overlooked. Addressing this issue, this review provides examples of voltage-gated ion channels displaying hysteretic behavior. Further, this review will discuss how Dynamic Voltage Dependence in voltage-gated channels can have a physiological role in electrical signaling. Furthermore, this review will elaborate on the current thoughts on the mechanism underlying hysteresis in voltage-gated channels.

  7. Upper and lower bounds for the ergodic capacity of MIMO Jacobi fading channels

    Science.gov (United States)

    Nafkha, Amor; Bonnefoi, Rémi

    2017-05-01

    In multi-(core/mode) optical fiber communication, the transmission channel can be modeled as a complex sub-matrix of the Haar-distributed unitary matrix (complex Jacobi unitary ensemble). In this letter, we present new analytical expressions of the upper and lower bounds for the ergodic capacity of multiple-input multiple-output Jacobi-fading channels. Recent results on the determinant of the Jacobi unitary ensemble are employed to derive a tight lower bound on the ergodic capacity. We use Jensen's inequality to provide an analytical closed-form upper bound to the ergodic capacity at any signal-to-noise ratio (SNR). Closed-form expressions of the ergodic capacity, at low and high SNR regimes, are also derived. Simulation results are presented to validate the accuracy of the derived expressions.

  8. DESIGN OF PARABOLIC CHANNELS

    Directory of Open Access Journals (Sweden)

    A. K. Alibekov

    2015-01-01

    Full Text Available The dependence of the apparent location of the hydraulic parameters of parabolic channels in earthen channel and volume of dredging required in their design and construction, on the basis of conditions to ensure the stability of the slope at the maximum water flow rate. 

  9. Channel Contract Behavior: the Role of Risk Attitudes, Risk Perceptions, and Channel Members' Market Structures

    NARCIS (Netherlands)

    Pennings, J.M.E.; Wansink, B.

    2004-01-01

    By integrating elements of both marketing and finance, we show how risk influences channel contract behavior. We model risk behavior as the interaction between risk attitude and risk perception (IRAP). An analysis of the joint channel decisions of 208 producers, wholesalers, and processors provides

  10. Bidirectional Fano Algorithm for Lattice Coded MIMO Channels

    KAUST Repository

    Al-Quwaiee, Hessa

    2013-05-08

    Recently, lattices - a mathematical representation of infinite discrete points in the Euclidean space, have become an effective way to describe and analyze communication systems especially system those that can be modeled as linear Gaussian vector channel model. Channel codes based on lattices are preferred due to three facts: lattice codes have simple structure, the code can achieve the limits of the channel, and they can be decoded efficiently using lattice decoders which can be considered as the Closest Lattice Point Search (CLPS). Since the time lattice codes were introduced to Multiple Input Multiple Output (MIMO) channel, Sphere Decoder (SD) has been an efficient way to implement lattice decoders. Sphere decoder offers the optimal performance at the expense of high decoding complexity especially for low signal-to-noise ratios (SNR) and for high- dimensional systems. On the other hand, linear and non-linear receivers, Minimum Mean Square Error (MMSE), and MMSE Decision-Feedback Equalization (DFE), provide the lowest decoding complexity but unfortunately with poor performance. Several studies works have been conducted in the last years to address the problem of designing low complexity decoders for the MIMO channel that can achieve near optimal performance. It was found that sequential decoders using backward tree 
search can bridge the gap between SD and MMSE. The sequential decoder provides an interesting performance-complexity trade-off using a bias term. Yet, the sequential decoder still suffers from high complexity for mid-to-high SNR values. In this work, we propose a new algorithm for Bidirectional Fano sequential Decoder (BFD) in order to reduce the mid-to-high SNR complexity. Our algorithm consists of first constructing a unidirectional Sequential Decoder based on forward search using the QL decomposition. After that, BFD incorporates two searches, forward and backward, to work simultaneously till they merge and find the closest lattice point to the

  11. K+ Block Is the Mechanism of Functional Asymmetry in Bacterial Na(v Channels.

    Directory of Open Access Journals (Sweden)

    Van Ngo

    2016-01-01

    Full Text Available Crystal structures of several bacterial Na(v channels have been recently published and molecular dynamics simulations of ion permeation through these channels are consistent with many electrophysiological properties of eukaryotic channels. Bacterial Na(v channels have been characterized as functionally asymmetric, and the mechanism of this asymmetry has not been clearly understood. To address this question, we combined non-equilibrium simulation data with two-dimensional equilibrium unperturbed landscapes generated by umbrella sampling and Weighted Histogram Analysis Methods for multiple ions traversing the selectivity filter of bacterial Na(vAb channel. This approach provided new insight into the mechanism of selective ion permeation in bacterial Na(v channels. The non-equilibrium simulations indicate that two or three extracellular K+ ions can block the entrance to the selectivity filter of Na(vAb in the presence of applied forces in the inward direction, but not in the outward direction. The block state occurs in an unstable local minimum of the equilibrium unperturbed free-energy landscape of two K+ ions that can be 'locked' in place by modest applied forces. In contrast to K+, three Na+ ions move favorably through the selectivity filter together as a unit in a loose "knock-on" mechanism of permeation in both inward and outward directions, and there is no similar local minimum in the two-dimensional free-energy landscape of two Na+ ions for a block state. The useful work predicted by the non-equilibrium simulations that is required to break the K+ block is equivalent to large applied potentials experimentally measured for two bacterial Na(v channels to induce inward currents of K+ ions. These results illustrate how inclusion of non-equilibrium factors in the simulations can provide detailed information about mechanisms of ion selectivity that is missing from mechanisms derived from either crystal structures or equilibrium unperturbed free

  12. Biology of the KCNQ1 Potassium Channel

    Directory of Open Access Journals (Sweden)

    Geoffrey W. Abbott

    2014-01-01

    Full Text Available Ion channels are essential for basic cellular function and for processes including sensory perception and intercellular communication in multicellular organisms. Voltage-gated potassium (Kv channels facilitate dynamic cellular repolarization during an action potential, opening in response to membrane depolarization to facilitate K+ efflux. In both excitable and nonexcitable cells other, constitutively active, K+ channels provide a relatively constant repolarizing force to control membrane potential, ion homeostasis, and secretory processes. Of the forty known human Kv channel pore-forming α subunits that coassemble in various combinations to form the fundamental tetrameric channel pore and voltage sensor module, KCNQ1 is unique. KCNQ1 stands alone in having the capacity to form either channels that are voltage-dependent and require membrane depolarization for activation, or constitutively active channels. In mammals, KCNQ1 regulates processes including gastric acid secretion, thyroid hormone biosynthesis, salt and glucose homeostasis, and cell volume and in some species is required for rhythmic beating of the heart. In this review, the author discusses the unique functional properties, regulation, cell biology, diverse physiological roles, and involvement in human disease states of this chameleonic K+ channel.

  13. Cl- channels in apoptosis

    DEFF Research Database (Denmark)

    Wanitchakool, Podchanart; Ousingsawat, Jiraporn; Sirianant, Lalida

    2016-01-01

    A remarkable feature of apoptosis is the initial massive cell shrinkage, which requires opening of ion channels to allow release of K(+), Cl(-), and organic osmolytes to drive osmotic water movement and cell shrinkage. This article focuses on the role of the Cl(-) channels LRRC8, TMEM16/anoctamin......, and cystic fibrosis transmembrane conductance regulator (CFTR) in cellular apoptosis. LRRC8A-E has been identified as a volume-regulated anion channel expressed in many cell types. It was shown to be required for regulatory and apoptotic volume decrease (RVD, AVD) in cultured cell lines. Its presence also......(-) channels or as regulators of other apoptotic Cl(-) channels, such as LRRC8. CFTR has been known for its proapoptotic effects for some time, and this effect may be based on glutathione release from the cell and increase in cytosolic reactive oxygen species (ROS). Although we find that CFTR is activated...

  14. Cardiac potassium channel subtypes

    DEFF Research Database (Denmark)

    Schmitt, Nicole; Grunnet, Morten; Olesen, Søren-Peter

    2014-01-01

    About 10 distinct potassium channels in the heart are involved in shaping the action potential. Some of the K(+) channels are primarily responsible for early repolarization, whereas others drive late repolarization and still others are open throughout the cardiac cycle. Three main K(+) channels...... drive the late repolarization of the ventricle with some redundancy, and in atria this repolarization reserve is supplemented by the fairly atrial-specific KV1.5, Kir3, KCa, and K2P channels. The role of the latter two subtypes in atria is currently being clarified, and several findings indicate...... that they could constitute targets for new pharmacological treatment of atrial fibrillation. The interplay between the different K(+) channel subtypes in both atria and ventricle is dynamic, and a significant up- and downregulation occurs in disease states such as atrial fibrillation or heart failure...

  15. Athermalized channeled spectropolarimeter enhancement.

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Julia Craven; Way, Brandyn Michael; Mercier, Jeffrey Alan; Hunt, Jeffery P.

    2013-09-01

    Channeled spectropolarimetry can measure the complete polarization state of light as a function of wavelength. Typically, a channeled spectropolarimeter uses high order retarders made of uniaxial crystal to amplitude modulate the measured spectrum with the spectrally-dependent Stokes polarization information. A primary limitation of conventional channeled spectropolarimeters is related to the thermal variability of the retarders. Thermal variation often forces frequent system recalibration, particularly for field deployed systems. However, implementing thermally stable retarders, made of biaxial crystal, results in an athermal channeled spectropolarimeter that relieves the need for frequent recalibration. This report presents experimental results for an anthermalized channeled spectropolarimeter prototype produced using potassium titanyl phosphate. The results of this prototype are compared to the current thermal stabilization state of the art. Finally, the application of the technique to the thermal infrared is studied, and the athermalization concept is applied to an infrared imaging spectropolarimeter design.

  16. CHANNEL ESTIMATION TECHNIQUE

    DEFF Research Database (Denmark)

    2015-01-01

    A method includes determining a sequence of first coefficient estimates of a communication channel based on a sequence of pilots arranged according to a known pilot pattern and based on a receive signal, wherein the receive signal is based on the sequence of pilots transmitted over the communicat......A method includes determining a sequence of first coefficient estimates of a communication channel based on a sequence of pilots arranged according to a known pilot pattern and based on a receive signal, wherein the receive signal is based on the sequence of pilots transmitted over...... the communication channel. The method further includes determining a sequence of second coefficient estimates of the communication channel based on a decomposition of the first coefficient estimates in a dictionary matrix and a sparse vector of the second coefficient estimates, the dictionary matrix including...... filter characteristics of at least one known transceiver filter arranged in the communication channel....

  17. Extreme bosonic linear channels

    Science.gov (United States)

    Holevo, A. S.

    2013-02-01

    The set of all channels with a fixed input and output is convex. We first give a convenient formulation of the necessary and sufficient condition for a channel to be an extreme point of this set in terms of the complementary channel, a notion of great importance in quantum information theory. This formulation is based on the general approach to extremality of completely positive maps in an operator algebra in the spirit of Arveson. We then use this formulation to prove our main result: under certain nondegeneracy conditions, environmental purity is necessary and sufficient for the extremality of a bosonic linear (quasifree) channel. It hence follows that a Gaussian channel between finite-mode bosonic systems is extreme if and only if it has minimum noise.

  18. Multiple Perspectives / Multiple Readings

    Directory of Open Access Journals (Sweden)

    Simon Biggs

    2005-01-01

    Full Text Available People experience things from their own physical point of view. What they see is usually a function of where they are and what physical attitude they adopt relative to the subject. With augmented vision (periscopes, mirrors, remote cameras, etc we are able to see things from places where we are not present. With time-shifting technologies, such as the video recorder, we can also see things from the past; a time and a place we may never have visited.In recent artistic work I have been exploring the implications of digital technology, interactivity and internet connectivity that allow people to not so much space/time-shift their visual experience of things but rather see what happens when everybody is simultaneously able to see what everybody else can see. This is extrapolated through the remote networking of sites that are actual installation spaces; where the physical movements of viewers in the space generate multiple perspectives, linked to other similar sites at remote locations or to other viewers entering the shared data-space through a web based version of the work.This text explores the processes involved in such a practice and reflects on related questions regarding the non-singularity of being and the sense of self as linked to time and place.

  19. Multiple density layered insulator

    Science.gov (United States)

    Alger, Terry W.

    1994-01-01

    A multiple density layered insulator for use with a laser is disclosed wh provides at least two different insulation materials for a laser discharge tube, where the two insulation materials have different thermoconductivities. The multiple layer insulation materials provide for improved thermoconductivity capability for improved laser operation.

  20. Sequential Steps of CRAC Channel Activation

    Directory of Open Access Journals (Sweden)

    Raz Palty

    2017-05-01

    Full Text Available Interaction between the endoplasmic reticulum protein STIM1 and the plasma membrane channel ORAI1 generates calcium signals that are central for diverse cellular functions. How STIM1 binds and activates ORAI1 remains poorly understood. Using electrophysiological, optical, and biochemical techniques, we examined the effects of mutations in the STIM1-ORAI1 activating region (SOAR of STIM1. We find that SOAR mutants that are deficient in binding to resting ORAI1 channels are able to bind to and boost activation of partially activated ORAI1 channels. We further show that the STIM1 binding regions on ORAI1 undergo structural rearrangement during channel activation. The results suggest that activation of ORAI1 by SOAR occurs in multiple steps. In the first step, SOAR binds to ORAI1, partially activates the channel, and induces a rearrangement in the SOAR-binding site of ORAI1. That rearrangement of ORAI1 then permits sequential steps of SOAR binding, via distinct molecular interactions, to fully activate the channel.

  1. Design and fabricate multi channel microfluidic mold on top of glass slide using SU-8

    Science.gov (United States)

    Azman, N. A. N.; Rajapaksha, R. D. A. A.; Uda, M. N. A.; Hashim, U.

    2017-09-01

    Microfluidic is the study of fluid in microscale. Microfluidics provides miniaturized fluidic networks for processing and analyzing liquids in the nanoliter to milliliter range. Microfluidic device comprises of some essential segments or structure that are micromixer, microchannel and microchamber. The SU-8 mold is known as the most used technique in microfluidic fabrication due to the characteristic of very gooey polymer that can be spread over a thickness. In this study, in order to reduce the fabrication cost, the development and fabrication of SU-8 mold is replace by using a glass plate instead of silicon wafer which is used in the previous research. We designed a microfluidic chip for use with an IDE sensors to conduct multiplex detection of multiple channels. The microfluidic chip was designed to include multiplex detection for pathogen that consists of multiple channels of simultaneous results. The multi-channel microfluidic chip was designed, including the fluid outlet and inlet. A multi-channel microfluidic chip was used for pathogen detection. This paper sum up the fabrication of lab SU-8 mold using glass slide.

  2. Spatially dependent responses of a large-river fish assemblage to bank stabilization and side channels

    Science.gov (United States)

    Reinhold, Ann Marie; Bramblett, Robert G.; Zale, Alexander V.; Poole, Geoffrey C.; Roberts, David W.

    2017-01-01

    The alteration of rivers by anthropogenic bank stabilization to prevent the erosion of economically valuable lands and structures has become commonplace. However, such alteration has ambiguous consequences for fish assemblages, especially in large rivers. Because most large, temperate rivers have impoundments, it can be difficult to separate the influences of bank stabilization structures from those of main-stem impoundments, especially because both stabilization structures and impoundments can cause side-channel loss. Few large rivers are free flowing and retain extensive side channels, but the Yellowstone River (our study area) is one such river. We hypothesized that in this river (1) bank stabilization has changed fish assemblage structure by altering habitats, (2) side-channel availability has influenced fish assemblage structure by providing habitat heterogeneity, and (3) the influences of bank stabilization and side channels on fish assemblages were spatially scale dependent. We developed a spatially explicit framework to test these hypotheses. Fish assemblage structure varied with the extent of bank stabilization and the availability of side channels; however, not all assemblage subsets were influenced. Nevertheless, bank stabilization and side channels had different and sometimes opposite influences on the fish assemblage. The effects of side channels on fish were more consistent and widespread than those of bank stabilization; the catches of more fishes were positively correlated with side-channel availability than with the extent of bank stabilization. The influences of bank stabilization and side channels on the relative abundances of fish also varied, depending on species and river bend geomorphology. The variation in river morphology probably contributed to the assemblage differences between stabilized and reference river bends; stabilized alluvial pools were deeper than reference alluvial pools, but the depths of stabilized and reference bluff pools

  3. A Survey of Channel Modeling for UAV Communications

    KAUST Repository

    Khuwaja, Aziz Altaf

    2018-01-23

    Unmanned aerial vehicles (UAVs) have gained great interest for rapid deployment in both civil and military applications. UAV communication has its own distinctive channel characteristics compared with widely used cellular and satellite systems. Thus, accurate channel characterization is crucial for the performance optimization and design of efficient UAV communication systems. However, several challenges exist in UAV channel modeling. For example, propagation characteristics of UAV channels are still less explored for spatial and temporal variations in non-stationary channels. Also, airframe shadowing has not yet been investigated for small size rotary UAVs. This paper provides an extensive survey on the measurement campaigns launched for UAV channel modeling using low altitude platforms and discusses various channel characterization efforts. We also review the contemporary perspective of UAV channel modeling approaches and outline some future research challenges in this domain.

  4. Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel.

    Science.gov (United States)

    Zhang, Wei; Cheng, Li E; Kittelmann, Maike; Li, Jiefu; Petkovic, Maja; Cheng, Tong; Jin, Peng; Guo, Zhenhao; Göpfert, Martin C; Jan, Lily Yeh; Jan, Yuh Nung

    2015-09-10

    How metazoan mechanotransduction channels sense mechanical stimuli is not well understood. The NOMPC channel in the transient receptor potential (TRP) family, a mechanotransduction channel for Drosophila touch sensation and hearing, contains 29 Ankyrin repeats (ARs) that associate with microtubules. These ARs have been postulated to act as a tether that conveys force to the channel. Here, we report that these N-terminal ARs form a cytoplasmic domain essential for NOMPC mechanogating in vitro, mechanosensitivity of touch receptor neurons in vivo, and touch-induced behaviors of Drosophila larvae. Duplicating the ARs elongates the filaments that tether NOMPC to microtubules in mechanosensory neurons. Moreover, microtubule association is required for NOMPC mechanogating. Importantly, transferring the NOMPC ARs to mechanoinsensitive voltage-gated potassium channels confers mechanosensitivity to the chimeric channels. These experiments strongly support a tether mechanism of mechanogating for the NOMPC channel, providing insights into the basis of mechanosensitivity of mechanotransduction channels. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. KCNQ potassium channels in sensory system and neural circuits.

    Science.gov (United States)

    Wang, Jing-jing; Li, Yang

    2016-01-01

    M channels, an important regulator of neural excitability, are composed of four subunits of the Kv7 (KCNQ) K(+) channel family. M channels were named as such because their activity was suppressed by stimulation of muscarinic acetylcholine receptors. These channels are of particular interest because they are activated at the subthreshold membrane potentials. Furthermore, neural KCNQ channels are drug targets for the treatments of epilepsy and a variety of neurological disorders, including chronic and neuropathic pain, deafness, and mental illness. This review will update readers on the roles of KCNQ channels in the sensory system and neural circuits as well as discuss their respective mechanisms and the implications for physiology and medicine. We will also consider future perspectives and the development of additional pharmacological models, such as seizure, stroke, pain and mental illness, which work in combination with drug-design targeting of KCNQ channels. These models will hopefully deepen our understanding of KCNQ channels and provide general therapeutic prospects of related channelopathies.

  6. Major channels involved in neuropsychiatric disorders and therapeutic perspectives

    Science.gov (United States)

    Imbrici, Paola; Camerino, Diana Conte; Tricarico, Domenico

    2013-01-01

    Voltage-gated ion channels are important mediators of physiological functions in the central nervous system. The cyclic activation of these channels influences neurotransmitter release, neuron excitability, gene transcription, and plasticity, providing distinct brain areas with unique physiological and pharmacological response. A growing body of data has implicated ion channels in the susceptibility or pathogenesis of psychiatric diseases. Indeed, population studies support the association of polymorphisms in calcium and potassium channels with the genetic risk for bipolar disorders (BPDs) or schizophrenia. Moreover, point mutations in calcium, sodium, and potassium channel genes have been identified in some childhood developmental disorders. Finally, antibodies against potassium channel complexes occur in a series of autoimmune psychiatric diseases. Here we report recent studies assessing the role of calcium, sodium, and potassium channels in BPD, schizophrenia, and autism spectrum disorders, and briefly summarize promising pharmacological strategies targeted on ion channels for the therapy of mental illness and related genetic tests. PMID:23675382

  7. Major Channels Involved In Neuropsychiatric Disorders And Therapeutic Perspectives

    Directory of Open Access Journals (Sweden)

    Paola eImbrici

    2013-05-01

    Full Text Available Voltage-gated ion channels are important mediators of physiological functions in the central nervous system. The cyclic activation of these channels influences neurotransmitter release, neuron excitability, gene transcription and plasticity, providing distinct brain areas with unique physiological and pharmacological response. A growing body of data has implicated ion channels in the susceptibility or pathogenesis of psychiatric diseases. Indeed, population studies support the association of polymorphisms in calcium and potassium channels with the genetic risk for bipolar disorders or schizophrenia. Moreover, point mutations in calcium, sodium and potassium channel genes have been identified in some childhood developmental disorders. Finally, antibodies against potassium channel complexes occur in a series of autoimmune psychiatric diseases. Here we report recent studies assessing the role of calcium, sodium and potassium channels in bipolar disorder, schizophrenia and autism spectrum disorders, and briefly summarize promising pharmacological strategies targeted on ion channels for the therapy of mental illness and related genetic tests.

  8. "Cuz They Care about the People Who Goes There": The Multiple Roles of a Community-Based Youth Center in Providing "Youth (Comm)Unity" for Low-Income Chinese American Youth

    Science.gov (United States)

    Wong, Nga-Wing Anjela

    2010-01-01

    This article will explore the role of "CYC," a community-based youth center, in providing a sense of what I call "Youth (Comm)Unity" for Chinese American youth from low-income immigrant families. While CYC combines the youths' home and school worlds, it is also distinct from these worlds by forming a new and hybrid culture/space. In doing so, I…

  9. Assay for calcium channels

    Energy Technology Data Exchange (ETDEWEB)

    Glossmann, H.; Ferry, D.R.

    1985-01-01

    This chapter focuses on biochemical assays for Ca/sup 2 +/-selective channels in electrically excitable membranes which are blocked in electrophysiological and pharmacological experiments by verapamil, 1,4-dihydropyridines, diltiazen (and various other drugs), as well as inorganic di- or trivalent cations. The strategy employed is to use radiolabeled 1,4-dihydropyridine derivatives which block calcium channels with ED/sub 50/ values in the nanomolar range. Although tritiated d-cis-diltiazem and verapamil can be used to label calcium channels, the 1,4-dihydropyridines offer numerous advantages. The various sections cover tissue specificity of channel labeling, the complex interactions of divalent cations with the (/sup 3/H)nimodipine-labeled calcium channels, and the allosteric regulation of (/sup 3/H)nimodipine binding by the optically pure enantiomers of phenylalkylamine and benzothiazepine calcium channel blockers. A comparison of the properties of different tritiated 1,4-dihydropyridine radioligands and the iodinated channel probe (/sup 125/I)iodipine is given.

  10. Generalized internal multiple imaging

    KAUST Repository

    Zuberi, Mohammad Akbar Hosain

    2014-12-04

    Various examples are provided for generalized internal multiple imaging (GIMI). In one example, among others, a method includes generating a higher order internal multiple image using a background Green\\'s function and rendering the higher order internal multiple image for presentation. In another example, a system includes a computing device and a generalized internal multiple imaging (GIMI) application executable in the computing device. The GIMI application includes logic that generates a higher order internal multiple image using a background Green\\'s function and logic that renders the higher order internal multiple image for display on a display device. In another example, a non-transitory computer readable medium has a program executable by processing circuitry that generates a higher order internal multiple image using a background Green\\'s function and renders the higher order internal multiple image for display on a display device.

  11. Opportunistic spectrum access in cognitive radio based on channel switching

    KAUST Repository

    Gaaloul, Fakhreddine

    2012-01-01

    This paper investigates the performance of a cognitive radio transceiver that can monitor multiple channels and opportunistically use any one of them should it be available. In our work, we propose and compare two different opportunistic channel access schemes. The first scheme applies when the secondary user (SU) has access to only one channel. The second scheme applies when the SU has access to multiple channels but can at a given time monitor and access only one channel. Two switching strategies, namely the switch and examine and the switch and stay strategies, are proposed. For these proposed access schemes, we investigate their performance by deriving the analytical expression of the novel metric of the average access duration and the average waiting time and based on these two metrics a time average SU throughput formula is proposed to predict the performance of the secondary cognitive system. © 2012 ICST.

  12. Mode Switching for the Multi-Antenna Broadcast Channel Based on Delay and Channel Quantization

    Directory of Open Access Journals (Sweden)

    Jun Zhang

    2009-01-01

    Full Text Available Imperfect channel state information degrades the performance of multiple-input multiple-output (MIMO communications; its effects on single-user (SU and multiuser (MU MIMO transmissions are quite different. In particular, MU-MIMO suffers from residual interuser interference due to imperfect channel state information while SU-MIMO only suffers from a power loss. This paper compares the throughput loss of both SU and MU-MIMO in the broadcast channel due to delay and channel quantization. Accurate closed-form approximations are derived for achievable rates for both SU and MU-MIMO. It is shown that SU-MIMO is relatively robust to delayed and quantized channel information, while MU-MIMO with zero-forcing precoding loses its spatial multiplexing gain with a fixed delay or fixed codebook size. Based on derived achievable rates, a mode switching algorithm is proposed, which switches between SU and MU-MIMO modes to improve the spectral efficiency based on average signal-to-noise ratio (SNR, normalized Doppler frequency, and the channel quantization codebook size. The operating regions for SU and MU modes with different delays and codebook sizes are determined, and they can be used to select the preferred mode. It is shown that the MU mode is active only when the normalized Doppler frequency is very small, and the codebook size is large.

  13. Materials characterization for process integration of multi-channel gate all around (GAA) devices

    Science.gov (United States)

    Muthinti, Gangadhara Raja; Loubet, Nicolas; Chao, Robin; de la Peña, Abraham A.; Li, Juntao; Guillorn, Michael A.; Yamashita, Tenko; Kanakasabapathy, Sivananda; Gaudiello, John; Cepler, Aron J.; Sendelbach, Matthew; Emans, Susan; Wolfling, Shay; Ger, Avron; Kandel, Daniel; Koret, Roy; Lee, Wei Ti; Gin, Peter; Matney, Kevin; Wormington, Matthew

    2017-03-01

    Multi-channel gate all around (GAA) semiconductor devices march closer to becoming a reality in production as their maturity in development continues. From this development, an understanding of what physical parameters affecting the device has emerged. The importance of material property characterization relative to that of other physical parameters has continued to increase for GAA architecture when compared to its relative importance in earlier architectures. Among these materials properties are the concentration of Ge in SiGe channels and the strain in these channels and related films. But because these properties can be altered by many different process steps, each one adding its own variation to these parameters, their characterization and control at multiple steps in the process flow is crucial. This paper investigates the characterization of strain and Ge concentration, and the relationships between these properties, in the PFET SiGe channel material at the earliest stages of processing for GAA devices. Grown on a bulk Si substrate, multiple pairs of thin SiGe/Si layers that eventually form the basis of the PFET channel are measured and characterized in this study. Multiple measurement techniques are used to measure the material properties. In-line X-Ray Photoelectron Spectroscopy (XPS) and Low Energy X-Ray Fluorescence (LE-XRF) are used to characterize Ge content, while in-line High Resolution X-Ray Diffraction (HRXRD) is used to characterize strain. Because both patterned and un-patterned structures were investigated, scatterometry (also called optical critical dimension, or OCD) is used to provide valuable geometrical metrology.

  14. Computational Analysis of Protein Tunnels and Channels.

    Science.gov (United States)

    Brezovsky, Jan; Kozlikova, Barbora; Damborsky, Jiri

    2018-01-01

    Protein tunnels connecting the functional buried cavities with bulk solvent and protein channels, enabling the transport through biological membranes, represent the structural features that govern the exchange rates of ligands, ions, and water solvent. Tunnels and channels are present in a vast number of known proteins and provide control over their function. Modification of these structural features by protein engineering frequently provides proteins with improved properties. Here we present a detailed computational protocol employing the CAVER software that is applicable for: (1) the analysis of tunnels and channels in protein structures, and (2) the selection of hot-spot residues in tunnels or channels that can be mutagenized for improved activity, specificity, enantioselectivity, or stability.

  15. A numerical model for meltwater channel evolution in glaciers

    Directory of Open Access Journals (Sweden)

    A. H. Jarosch

    2012-04-01

    Full Text Available Meltwater channels form an integral part of the hydrological system of a glacier. Better understanding of how meltwater channels develop and evolve is required to fully comprehend supraglacial and englacial meltwater drainage. Incision of supraglacial stream channels and subsequent roof closure by ice deformation has been proposed in recent literature as a possible englacial conduit formation process. Field evidence for supraglacial stream incision has been found in Svalbard and Nepal. In Iceland, where volcanic activity provides meltwater with temperatures above 0 °C, rapid enlargement of supraglacial channels has been observed. Supraglacial channels provide meltwater through englacial passages to the subglacial hydrological systems of big ice sheets, which in turn affects ice sheet motion and their contribution to eustatic sea level change. By coupling, for the first time, a numerical ice dynamic model to a hydraulic model which includes heat transfer, we investigate the evolution of meltwater channels and their incision behaviour. We present results for different, constant meltwater fluxes, different channel slopes, different meltwater temperatures, different melt rate distributions in the channel as well as temporal variations in meltwater flux. The key parameters governing incision rate and depth are channel slope, meltwater temperature loss to the ice and meltwater flux. Channel width and geometry are controlled by melt rate distribution along the channel wall. Calculated Nusselt numbers suggest that turbulent mixing is the main heat transfer mechanism in the meltwater channels studied.

  16. Convergence of estuarine channels

    Science.gov (United States)

    Dronkers, Job

    2017-07-01

    Tide-dominated coastal plain estuaries have typically up-estuary convergent tidal channels. Analysis of estuarine characteristics indicates a dependence of the convergence length on relative tidal amplitude, relative intertidal area and river flow velocity. In order to explain these relationships we investigate a condition for continuity of net sediment transport throughout the estuary, corresponding to morphodynamic equilibrium. We show, by using an analytical solution of the tidal equations, that this condition is equivalent to a condition on the convergence length. This condition is evaluated for 21 estuaries in different regions of the world. It appears that the convergence length determined in this way can explain observed convergence lengths for the considered set of estuaries. The dependence of the convergence length on different estuarine characteristics is analysed by solving the fully coupled hydro-morphodynamic equations. We show that this dependence limits the range of variation of the tidal velocity amplitude. The analysis provides insight in the morphological response of estuaries to human interventions. The condition can easily be evaluated to yield an estimate of this response.

  17. Overlay Cognitive Radios With Channel-Aware Adaptive Link Selection and Buffer-Aided Relaying

    KAUST Repository

    Shaqfeh, Mohammad

    2015-08-01

    The aim of this work is to maximize the long-term average achievable rate region of a primary and a secondary source-destination pairs operating in an overlay setup over block-fading channels. To achieve this objective, we propose an opportunistic strategy to grant channel access to the primary and secondary sources based on the channel conditions in order to exploit the available multiple-link diversity gains in the system. The secondary source has causal knowledge of the primary messages and it acts as a relay of the primary source in return for getting access to the channel. To maximize the gains of relaying, the relay and destination are equipped with buffers to enable the use of channel-aware adaptive link selection. We propose and optimize different link selection policies and characterize their expected achievable rates. Also, we provide several numerical results to demonstrate the evident mutual benefits of buffer-aided cooperation and adaptive link selection to the primary and the secondary source-destination pairs. © 1972-2012 IEEE.

  18. A New Variational Approach for Multiplicative Noise and Blur Removal.

    Directory of Open Access Journals (Sweden)

    Asmat Ullah

    Full Text Available This paper proposes a new variational model for joint multiplicative denoising and deblurring. It combines a total generalized variation filter (which has been proved to be able to reduce the blocky-effects by being aware of high-order smoothness and shearlet transform (that effectively preserves anisotropic image features such as sharp edges, curves and so on. The new model takes the advantage of both regularizers since it is able to minimize the staircase effects while preserving sharp edges, textures and other fine image details. The existence and uniqueness of a solution to the proposed variational model is also discussed. The resulting energy functional is then solved by using alternating direction method of multipliers. Numerical experiments showing that the proposed model achieves satisfactory restoration results, both visually and quantitatively in handling the blur (motion, Gaussian, disk, and Moffat and multiplicative noise (Gaussian, Gamma, or Rayleigh reduction. A comparison with other recent methods in this field is provided as well. The proposed model can also be applied for restoring both single and multi-channel images contaminated with multiplicative noise, and permit cross-channel blurs when the underlying image has more than one channel. Numerical tests on color images are conducted to demonstrate the effectiveness of the proposed model.

  19. [Multiple apheresis].

    Science.gov (United States)

    Coffe, C

    2007-05-01

    Multiple apheresis makes it possible to obtain at least two labile blood components from a single donor using a cell separator. It can be either multicomponent apheresis leading to the preparation of at least two different blood component types or red blood cell apheresis providing two identical red blood cell concentrates. These techniques available in addition to whole blood donation, are modifying collection strategies in many Etablissements Français du Sang and will contribute to improve stock logistics in the future. In areas with insufficient stock, these procedures will help achieve blood component self-sufficiency. The author first describes the principle underlying different--current or future--techniques as well as their advantages and drawbacks. He finally addresses the potential impact of these processes on the evolution of blood collection and the advantages to be gained.

  20. Correlation Between Channel Profile and Plan View Drainage Network Architecture

    Science.gov (United States)

    Shelef, E.; Hilley, G. E.

    2011-12-01

    This research explores the relationship between the plan-view network and profile geometry of channels using high-resolution digital topography and numerical models. In particular, we study the relations between plan-view morphometrics of the channel network and the mechanics of land-shaping processes as reflected by channel profile concavity. This analysis addresses one of the long-standing questions in geomorphology relating to the mechanistic significance of various plan-view channel network geometry measures. Statistically based studies suggest that Hortonian measures of channel network architecture (e.g. bifurcation ratio, area ratio, and length ratio) describe virtually all possible network geometries, and hence are not diagnostic when evaluating the origins of the geometry of a particular network. Our analyses of high resolution DEMs that capture different channel profile concavities (i.e debris flow vs. fluvial flows), as well as the topography of landscapes produced by process-based numerical models affirms this conclusion and indicates that Hortonian measures, as well as Hack exponent, are insensitive to channel concavity. In contrast, channel frequency (number of channel segments per area) appears to provide a measure that is sensitive to channel concavity. As such, channel frequency appears to discern between landscapes dominated by different land-shaping processes that produce different channel profile concavities. In the context of headword growing networks, the observed relations between concavity and channel frequency can be modeled through the coupled effect of concavity and surface roughness on the competition between headword growing channels. Our results suggest that the plan-view geometry of channel networks does not simply arise from random deflection of channels that once joined, cannot separate, but rather reflects the underlying processes that incise through rock and transport mass through the channel network

  1. Channel Choice: A Literature Review

    DEFF Research Database (Denmark)

    Østergaard Madsen, Christian; Kræmmergaard, Pernille

    2015-01-01

    The channel choice branch of e-government studies citizens’ and businesses’ choice of channels for interacting with government, and how government organizations can integrate channels and migrate users towards the most cost-efficient channels. In spite of the valuable contributions offered no sys...... no systematic overview exist of channel choice. We present a literature review of channel choice studies in government to citizen context identifying authors, countries, methods, concepts, units of analysis, and theories, and offer suggestionsfor future studies....

  2. Two-channel X-ray reflectometer

    CERN Document Server

    Touryanski, A G; Pirshin, I V

    2000-01-01

    The two-channel X-ray reflectometer is proposed providing an increase in accuracy and sensitivity especially to nanoscale oxide layers. The reflectometer has two independent measuring channels controlled by a processor and the beam-splitting and spectral selection device based on a row of semitransparent plates of pyrolitic graphite. Results of reflection curve measurements in a relative mode are presented for an Ni film and GaAs monocrystal.

  3. Pilot-Assisted Adaptive Channel Estimation for Coded MC-CDMA with ICI Cancellation

    Science.gov (United States)

    Yui, Tatsunori; Tomeba, Hiromichi; Adachi, Fumiyuki

    One of the promising wireless access techniques for the next generation mobile communications systems is multi-carrier code division multiple access (MC-CDMA). MC-CDMA can provide good transmission performance owing to the frequency diversity effect in a severe frequency-selective fading channel. However, the bit error rate (BER) performance of coded MC-CDMA is inferior to that of orthogonal frequency division multiplexing (OFDM) due to the residual inter-code interference (ICI) after frequency-domain equalization (FDE). Recently, we proposed a frequency-domain soft interference cancellation (FDSIC) to reduce the residual ICI and confirmed by computer simulation that the MC-CDMA with FDSIC provides better BER performance than OFDM. However, ideal channel estimation was assumed. In this paper, we propose adaptive decision-feedback channel estimation (ADFCE) and evaluate by computer simulation the average BER and throughput performances of turbo-coded MC-CDMA with FDSIC. We show that even if a practical channel estimation is used, MC-CDMA with FDSIC can still provide better performance than OFDM.

  4. Low SNR capacity for MIMO Rician and Rayleigh-product fading channels with single co-channel interferer and noise

    KAUST Repository

    Zhong, Caijun

    2010-09-01

    This paper studies the ergodic capacity of multiple-input multiple-output (MIMO) systems with a single co-channel interferer in the low signal-to-noise-ratio (SNR) regime. Two MIMO models namely Rician and Rayleigh-product channels are investigated. Exact analytical expressions for the minimum energy per information bit, {Eb/N0min, and wideband slope, S0, are derived for both channels. Our results show that the minimum energy per information bit is the same for both channels while their wideband slopes differ significantly. Further, the impact of the numbers of transmit and receive antennas, the Rician K factor, the channel mean matrix and the interference-to-noise-ratio (INR) on the capacity, is addressed. Results indicate that interference degrades the capacity by increasing the required minimum energy per information bit and reducing the wideband slope. Simulation results validate our analytical results. © 2010 IEEE.

  5. Neuromyelitis optica and multiple sclerosis

    DEFF Research Database (Denmark)

    Bennett, J. L.; de Seze, J.; Lana-Peixoto, M.

    2015-01-01

    Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel...

  6. Envelope Interactions in Multi-Channel Amplitude Modulation Frequency Discrimination by Cochlear Implant Users

    NARCIS (Netherlands)

    Galvin, John J.; Oba, Sandra I.; Başkent, Deniz; Chatterjee, Monita; Fu, Qian-Jie

    2015-01-01

    Rationale Previous cochlear implant (CI) studies have shown that single-channel amplitude modulation frequency discrimination (AMFD) can be improved when coherent modulation is delivered to additional channels. It is unclear whether the multi-channel advantage is due to increased loudness, multiple

  7. Molecular dynamics simulation of a synthetic ion channel.

    Science.gov (United States)

    Zhong, Q; Jiang, Q; Moore, P B; Newns, D M; Klein, M L

    1998-01-01

    A molecular dynamics simulation has been performed on a synthetic membrane-spanning ion channel, consisting of four alpha-helical peptides, each of which is composed of the amino acids leucine (L) and serine (S), with the sequence Ac-(LSLLLSL)3-CONH2. This four-helix bundle has been shown experimentally to act as a proton-conducting channel in a membrane environment. In the present simulation, the channel was initially assembled as a parallel bundle in the octane portion of a phase-separated water/octane system, which provided a membrane-mimetic environment. An explicit reversible multiple-time-step integrator was used to generate a dynamical trajectory, a few nanoseconds in duration for this composite system on a parallel computer, under ambient conditions. After more than 1 ns, the four helices were found to adopt an associated dimer state with twofold symmetry, which evolved into a coiled-coil tetrameric structure with a left-handed twist. In the coiled-coil state, the polar serine side chains interact to form a layered structure with the core of the bundle filled with H2O. The dipoles of these H2O molecules tended to align opposite the net dipole of the peptide bundle. The calculated dipole relaxation function of the pore H2O molecules exhibits two reorientation times. One is approximately 3.2 ps, and the other is approximately 100 times longer. The diffusion coefficient of the pore H2O is about one-third of the bulk H2O value. The total dipole moment and the inertia tensor of the peptide bundle have been calculated and reveal slow (300 ps) collective oscillatory motions. Our results, which are based on a simple united atom force-field model, suggest that the function of this synthetic ion channel is likely inextricably coupled to its dynamical behavior.

  8. Plasma Channel Diagnostic Based on Laser Centroid Oscillations

    Energy Technology Data Exchange (ETDEWEB)

    Gonsalves, Anthony; Nakamura, Kei; Lin, Chen; Osterhoff, Jens; Shiraishi, Satomi; Schroeder, Carl; Geddes, Cameron; Toth, Csaba; Esarey, Eric; Leemans, Wim

    2010-09-09

    A technique has been developed for measuring the properties of discharge-based plasma channels by monitoring the centroid location of a laser beam exiting the channel as a function of input alignment offset between the laser and the channel. The centroid position of low-intensity (<10{sup 14}Wcm{sup -2}) laser pulses focused at the input of a hydrogen-filled capillary discharge waveguide was scanned and the exit positions recorded to determine the channel shape and depth with an accuracy of a few %. In addition, accurate alignment of the laser beam through the plasma channel can be provided by minimizing laser centroid motion at the channel exit as the channel depth is scanned either by scanning the plasma density or the discharge timing. The improvement in alignment accuracy provided by this technique will be crucial for minimizing electron beam pointing errors in laser plasma accelerators.

  9. Multi-rate control over AWGN channels via analog joint source-channel coding

    KAUST Repository

    Khina, Anatoly

    2017-01-05

    We consider the problem of controlling an unstable plant over an additive white Gaussian noise (AWGN) channel with a transmit power constraint, where the signaling rate of communication is larger than the sampling rate (for generating observations and applying control inputs) of the underlying plant. Such a situation is quite common since sampling is done at a rate that captures the dynamics of the plant and which is often much lower than the rate that can be communicated. This setting offers the opportunity of improving the system performance by employing multiple channel uses to convey a single message (output plant observation or control input). Common ways of doing so are through either repeating the message, or by quantizing it to a number of bits and then transmitting a channel coded version of the bits whose length is commensurate with the number of channel uses per sampled message. We argue that such “separated source and channel coding” can be suboptimal and propose to perform joint source-channel coding. Since the block length is short we obviate the need to go to the digital domain altogether and instead consider analog joint source-channel coding. For the case where the communication signaling rate is twice the sampling rate, we employ the Archimedean bi-spiral-based Shannon-Kotel\\'nikov analog maps to show significant improvement in stability margins and linear-quadratic Gaussian (LQG) costs over simple schemes that employ repetition.

  10. Self-calibrated multiple-echo acquisition with radial trajectories using the conjugate gradient method (SMART-CG).

    Science.gov (United States)

    Jung, Youngkyoo; Samsonov, Alexey A; Bydder, Mark; Block, Walter F

    2011-04-01

    To remove phase inconsistencies between multiple echoes, an algorithm using a radial acquisition to provide inherent phase and magnitude information for self correction was developed. The information also allows simultaneous support for parallel imaging for multiple coil acquisitions. Without a separate field map acquisition, a phase estimate from each echo in multiple echo train was generated. When using a multiple channel coil, magnitude and phase estimates from each echo provide in vivo coil sensitivities. An algorithm based on the conjugate gradient method uses these estimates to simultaneously remove phase inconsistencies between echoes, and in the case of multiple coil acquisition, simultaneously provides parallel imaging benefits. The algorithm is demonstrated on single channel, multiple channel, and undersampled data. Substantial image quality improvements were demonstrated. Signal dropouts were completely removed and undersampling artifacts were well suppressed. The suggested algorithm is able to remove phase cancellation and undersampling artifacts simultaneously and to improve image quality of multiecho radial imaging, the important technique for fast three-dimensional MRI data acquisition. Copyright © 2011 Wiley-Liss, Inc.

  11. Calcium channel blocker poisoning

    Directory of Open Access Journals (Sweden)

    Miran Brvar

    2005-04-01

    Full Text Available Background: Calcium channel blockers act at L-type calcium channels in cardiac and vascular smooth muscles by preventing calcium influx into cells with resultant decrease in vascular tone and cardiac inotropy, chronotropy and dromotropy. Poisoning with calcium channel blockers results in reduced cardiac output, bradycardia, atrioventricular block, hypotension and shock. The findings of hypotension and bradycardia should suggest poisoning with calcium channel blockers.Conclusions: Treatment includes immediate gastric lavage and whole-bowel irrigation in case of ingestion of sustainedrelease products. All patients should receive an activated charcoal orally. Specific treatment includes calcium, glucagone and insulin, which proved especially useful in shocked patients. Supportive care including the use of catecholamines is not always effective. In the setting of failure of pharmacological therapy transvenous pacing, balloon pump and cardiopulmonary by-pass may be necessary.

  12. Sensing with Ion Channels

    CERN Document Server

    Martinac, Boris

    2008-01-01

    All living cells are able to detect and translate environmental stimuli into biologically meaningful signals. Sensations of touch, hearing, sight, taste, smell or pain are essential to the survival of all living organisms. The importance of sensory input for the existence of life thus justifies the effort made to understand its molecular origins. Sensing with Ion Channels focuses on ion channels as key molecules enabling biological systems to sense and process the physical and chemical stimuli that act upon cells in their living environment. Its aim is to serve as a reference to ion channel specialists and as a source of new information to non specialists who want to learn about the structural and functional diversity of ion channels and their role in sensory physiology.

  13. Channelized Streams in Iowa

    Data.gov (United States)

    Iowa State University GIS Support and Research Facility — This draft dataset consists of all ditches or channelized pieces of stream that could be identified using three input datasets; namely the1:24,000 National...

  14. 28-Channel rotary transformer

    Science.gov (United States)

    Mclyman, W. T.

    1981-01-01

    Transformer transmits power and digital data across rotating interface. Array has many parallel data channels, each with potential l megabaud data rate. Ferrite-cored transformers are spaced along rotor; airgap between them reduces crosstalk.

  15. Geomorphic changes resulting from floods in reconfigured gravel-bed river channels in Colorado, USA

    Science.gov (United States)

    Elliott, J.G.; Capesius, J.P.

    2009-01-01

    Geomorphic changes in reconfi gured reaches of three Colorado rivers in response to floods in 2005 provide a benchmark for "restoration" assessment. Sedimententrainment potential is expressed as the ratio of the shear stress from the 2 yr, 5 yr, 10 yr, and 2005 floods to the critical shear stress for sediment. Some observed response was explained by the excess of flood shear stress relative to the resisting force of the sediment. Bed-load entrainment in the Uncompahgre River and the North Fork Gunnison River, during 4 and 6 yr floods respectively, resulted in streambed scour, streambed deposition, lateral-bar accretion, and channel migration at various locations. Some constructed boulder and log structures failed because of high rates of bank erosion or bed-material deposition. The Lake Fork showed little or no net change after the 2005 flood; however, this channel had not conveyed floods greater than the 2.5 yr flood since reconfi guration. Channel slope and the 2 yr flood, a surrogate for bankfull discharge, from all three reconfi gured reaches plotted above the Leopold and Wolman channel-pattern threshold in the "braided channel" region, indicating that braiding, rather than a single-thread meandering channel, and midchannel bar formation may be the natural tendency of these gravel-bed reaches. When plotted against a total stream-power and median-sediment-size threshold for the 2 yr flood, however, the Lake Fork plotted in the "single-thread channel" region, the North Fork Gunnison plotted in the " multiplethread" region, and the Uncompahgre River plotted on the threshold. All three rivers plotted in the multiple-thread region for floods of 5 yr recurrence or greater. ?? 2009 Geological Society of America.

  16. Allosteric modulators of the hERG K{sup +} channel

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Zhiyi, E-mail: z.yu@lacdr.leidenuniv.nl; Klaasse, Elisabeth, E-mail: elisabethklaasse@hotmail.com; Heitman, Laura H., E-mail: l.h.heitman@lacdr.leidenuniv.nl; IJzerman, Adriaan P., E-mail: ijzerman@lacdr.leidenuniv.nl

    2014-01-01

    Drugs that block the cardiac K{sup +} channel encoded by the human ether-à-go-go gene (hERG) have been associated with QT interval prolongation leading to proarrhythmia, and in some cases, sudden cardiac death. Because of special structural features of the hERG K{sup +} channel, it has become a promiscuous target that interacts with pharmaceuticals of widely varying chemical structures and a reason for concern in the pharmaceutical industry. The structural diversity suggests that multiple binding sites are available on the channel with possible allosteric interactions between them. In the present study, three reference compounds and nine compounds of a previously disclosed series were evaluated for their allosteric effects on the binding of [{sup 3}H]astemizole and [{sup 3}H]dofetilide to the hERG K{sup +} channel. LUF6200 was identified as an allosteric inhibitor in dissociation assays with both radioligands, yielding similar EC{sub 50} values in the low micromolar range. However, potassium ions increased the binding of the two radioligands in a concentration-dependent manner, and their EC{sub 50} values were not significantly different, indicating that potassium ions behaved as allosteric enhancers. Furthermore, addition of potassium ions resulted in a concentration-dependent leftward shift of the LUF6200 response curve, suggesting positive cooperativity and distinct allosteric sites for them. In conclusion, our investigations provide evidence for allosteric modulation of the hERG K{sup +} channel, which is discussed in the light of findings on other ion channels. - Highlights: • Allosteric modulators on the hERG K{sup +} channel were evaluated in binding assays. • LUF6200 was identified as a potent allosteric inhibitor. • Potassium ions were found to behave as allosteric enhancers. • Positive cooperativity and distinct allosteric sites for them were proposed.

  17. Channelling versus inversion

    DEFF Research Database (Denmark)

    Gale, A.S.; Surlyk, Finn; Anderskouv, Kresten

    2013-01-01

    Evidence from regional stratigraphical patterns in Santonian−Campanian chalk is used to infer the presence of a very broad channel system (5 km across) with a depth of at least 50 m, running NNW−SSE across the eastern Isle of Wight; only the western part of the channel wall and fill is exposed. W......−Campanian chalks in the eastern Isle of Wight, involving penecontemporaneous tectonic inversion of the underlying basement structure, are rejected....

  18. Ion Channels in Leukocytes

    Science.gov (United States)

    1991-07-01

    state (170).-Single K, channel currents were blocked by gesting that the synthesis of new channel protein was external-Ba (2.5 mM) and, like whole...Hg, La, cells, NK cells, human 2M2, 267 nifedipine, and murine B-cells diltiazem, chlorpromazine , forskolin, trifluorperazine, noxiustoxin -K, (I...Cells that ultimately leads to an increase in DNA synthesis and cell division. T lymphocytes develop in the thymus and have both effector and

  19. Optimization of Training Signal Transmission for Estimating MIMO Channel under Antenna Mutual Coupling Conditions

    Directory of Open Access Journals (Sweden)

    Xia Liu

    2010-01-01

    Full Text Available This paper reports investigations on the effect of antenna mutual coupling on performance of training-based Multiple-Input Multiple-Output (MIMO channel estimation. The influence of mutual coupling is assessed for two training-based channel estimation methods, Scaled Least Square (SLS and Minimum Mean Square Error (MMSE. It is shown that the accuracy of MIMO channel estimation is governed by the sum of eigenvalues of channel correlation matrix which in turn is influenced by the mutual coupling in transmitting and receiving array antennas. A water-filling-based procedure is proposed to optimize the training signal transmission to minimize the MIMO channel estimation errors.

  20. Multiple Sclerosis

    Science.gov (United States)

    Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the myelin ... healthy cells in your body by mistake. Multiple sclerosis affects women more than men. It often begins ...