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Sample records for proton beams striking

  1. Polarized proton beams

    International Nuclear Information System (INIS)

    Roser, T.

    1995-01-01

    The acceleration of polarized proton beams in circular accelerators is complicated by the presence of numerous depolarizing spin resonances. Careful and tedious minimization of polarization loss at each of these resonances allowed acceleration of polarized proton beams up to 22 GeV. It has been the hope that Siberian Snakes, which are local spin rotators inserted into ring accelerators, would eliminate these resonances and allow acceleration of polarized beams with the same ease and efficiency that is now routine for unpolarized beams. First tests at IUCF with a full Siberian Snake showed that the spin dynamics with a Snake can be understood in detail. The author now has results of the first tests of a partial Siberian Snake at the AGS, accelerating polarized protons to an energy of about 25 GeV. These successful tests of storage and acceleration of polarized proton beams open up new possibilities such as stored polarized beams for internal target experiments and high energy polarized proton colliders

  2. Beam-Beam Effects in the SPS Proton-Anti Proton Collider

    CERN Document Server

    Cornelis, K.

    2014-01-01

    During the proton-anti proton collider run several experiments were carried out in order to understand the effect of the beam-beam interaction on backgrounds and lifetimes. In this talk a selection of these experiments will be presented. From these experiments, the importance of relative beam sizes and tune ripple could be demonstrated.

  3. Intense-proton-beam transport through an insulator beam guide

    International Nuclear Information System (INIS)

    Hanamori, Susumu; Kawata, Shigeo; Kikuchi, Takashi; Fujita, Akira; Chiba, Yasunobu; Hikita, Taisuke; Kato, Shigeru

    1998-01-01

    In this paper we study intense-proton-beam transport through an insulator guide. In our previous papers (Jpn. J. Appl. Phys. 34 (1995) L520, Jpn. J. Appl. Phys. 35 (1996) L1127) we proposed a new system for intense-electron-beam transport using an insulator guide. In contrast to the electron beam, an intense-proton beam tends to generate a virtual anode, because of the large proton mass. The virtual anode formation at the initial stage is prevented by prefilled plasma in this system. During and after this, electrons are extracted from the plasma generated at the insulator surface by the proton beam space charge and expand over the transport area. The proton beam charge is effectively neutralized by the electrons. Consequently, the proton beam propagates efficiently through the insulator beam guide. The electron extraction is self-regulated by the net space charge of the proton beam. (author)

  4. Conceptual design of proton beam window

    International Nuclear Information System (INIS)

    Teraoku, Takuji; Kaminaga, Masanori; Terada, Atsuhiko; Ishikura, Syuichi; Kinoshita, Hidetaka; Hino, Ryutaro

    2001-01-01

    In a MW-scale neutron scattering facility coupled with a high-intensity proton accelerator, a proton beam window is installed as the boundary between a high vacuum region of the proton beam transport line and a helium environment around the target assembly working as a neutron source. The window is cooled by water so as to remove high volumetric heat generated by the proton beam. A concept of the flat-type proton beam window consisting of two plates of 3 mm thick was proposed, which was found to be feasible under the proton beam power of 5 MW through thermal-hydraulic and structural strength analyses. (authors)

  5. Proton Beam Writing

    International Nuclear Information System (INIS)

    Rajta, I.; Szilasi, S.Z.; Csige, I.; Baradacs, E.

    2005-01-01

    Complete text of publication follows. Refractive index depth profile in PMMA due to proton irradiation Proton Beam Writing has been successfully used to create buried channel waveguides in PMMA, which suggested that proton irradiation increases the refractive index. To investigate this effect, PMMA samples were irradiated by 1.7-2.1 MeV proton beam. Spectroscopic Ellipsometry has been used to investigate the depth profile of the refractive index. An increase of the refractive index was observed in the order of 0.01, which is approximately one order of magnitude higher than the detection limit. The highest increase of the refractive index occurs at the end of range, i.e. we found a good correlation with the Bragg curve of the energy loss. Hardness changes in PMMA due to proton beam micromachining As protons penetrate a target material and lose their energy according to the Bragg curve, the energy loss is different at different depths. This causes depth-dependent changes of some physical properties in the target material (e.g. refractive index, hardness). In order to characterize the changes of hardness and other mechanical properties as a function of beam penetration depth, systematic investigations have been performed on PMMA, the most common resist material used in proton beam micromachining. Silicon check valve made by proton beam micromachining The possible application of Proton Beam Micromachining (PBM) has been demonstrated by a few authors for creating 3D Si microstructures. In this work we present alternative methods for the formation of a simple a non-return valve for microfluidic applications. Two different approaches have been applied, in both cases we exploited characteristic features of the PBM technique and the selective formation and dissolution of porous Si over the implantation damaged areas. In the first case we implanted 10 μm thick cantilever-type membrane of the valve normally to the crystal surface and at 30-60 degrees to the sidewalls of the

  6. Proton beam monitor chamber calibration

    International Nuclear Information System (INIS)

    Gomà, C; Meer, D; Safai, S; Lorentini, S

    2014-01-01

    The first goal of this paper is to clarify the reference conditions for the reference dosimetry of clinical proton beams. A clear distinction is made between proton beam delivery systems which should be calibrated with a spread-out Bragg peak field and those that should be calibrated with a (pseudo-)monoenergetic proton beam. For the latter, this paper also compares two independent dosimetry techniques to calibrate the beam monitor chambers: absolute dosimetry (of the number of protons exiting the nozzle) with a Faraday cup and reference dosimetry (i.e. determination of the absorbed dose to water under IAEA TRS-398 reference conditions) with an ionization chamber. To compare the two techniques, Monte Carlo simulations were performed to convert dose-to-water to proton fluence. A good agreement was found between the Faraday cup technique and the reference dosimetry with a plane-parallel ionization chamber. The differences—of the order of 3%—were found to be within the uncertainty of the comparison. For cylindrical ionization chambers, however, the agreement was only possible when positioning the effective point of measurement of the chamber at the reference measurement depth—i.e. not complying with IAEA TRS-398 recommendations. In conclusion, for cylindrical ionization chambers, IAEA TRS-398 reference conditions for monoenergetic proton beams led to a systematic error in the determination of the absorbed dose to water, especially relevant for low-energy proton beams. To overcome this problem, the effective point of measurement of cylindrical ionization chambers should be taken into account when positioning the reference point of the chamber. Within the current IAEA TRS-398 recommendations, it seems advisable to use plane-parallel ionization chambers—rather than cylindrical chambers—for the reference dosimetry of pseudo-monoenergetic proton beams. (paper)

  7. Development of disease animal models using proton beam

    International Nuclear Information System (INIS)

    Nam, K. H.; Kim, E. K.; Kim, H. R.; Seo, Y. W.

    2010-03-01

    To identify proper proton beam dose for mutant mouse development, total 7 times of proton beam were performed. There are too low incidence of mutation in pup mouse which were derived embryos radiated by 1Gy proton beam. Some mutation could be identified in pup mice which were derived embryos radiated by 1.5-2.5Gy proton beam. Mouse embryos irradiated with 1-10Gy of proton beam were inhibited in their in vitro development to 2 cell stage. There was no pups born from embryos which were irradiated with proton beam over 3 Gy. Early mouse development were greatly inhibited by proton beam irradiation of over 10Gy when cultured in vitro. In conclusion, it is efficient to irradiate mouse embryo with 1.5-2.5Gy of proton beam for development of mutant mice

  8. The clinical case for proton beam therapy

    International Nuclear Information System (INIS)

    Foote, Robert L; Haddock, Michael G; Yan, Elizabeth; Laack, Nadia N; Arndt, Carola A S

    2012-01-01

    Over the past 20 years, several proton beam treatment programs have been implemented throughout the United States. Increasingly, the number of new programs under development is growing. Proton beam therapy has the potential for improving tumor control and survival through dose escalation. It also has potential for reducing harm to normal organs through dose reduction. However, proton beam therapy is more costly than conventional x-ray therapy. This increased cost may be offset by improved function, improved quality of life, and reduced costs related to treating the late effects of therapy. Clinical research opportunities are abundant to determine which patients will gain the most benefit from proton beam therapy. We review the clinical case for proton beam therapy. Proton beam therapy is a technically advanced and promising form of radiation therapy

  9. Proton-beam radiation therapy dosimetry standardization

    International Nuclear Information System (INIS)

    Gall, K.P.

    1995-01-01

    Beams of protons have been used for radiation therapy applications for over 40 years. In the last decade the number of facilities treating patients and the total number of patients being treated has begun go grow rapidly. Due to the limited and experimental nature of the early programs, dosimetry protocols tended to be locally defined. With the publication of the AAPM Task Group 20 report open-quotes Protocol for Dosimetry of Heavy Charged Particlesclose quotes and the open-quotes European Code of Practice for Proton-Beam Dosimetryclose quotes the practice of determining dose in proton-beam therapy was somewhat unified. The ICRU has also recently commissioned a report on recommendations for proton-beam dosimetry. There have been three main methods of determining proton dose; the Faraday cup technique, the ionization chamber technique, and the calorimeter technique. For practical reasons the ionization chamber technique has become the most widely used. However, due to large errors in basic parameters (e.g., W-value) is also has a large uncertainty for absolute dose. It has been proposed that the development of water calorimeter absorbed dose standards would reduce the uncertainty in absolute proton dose as well as the relative dose between megavoltage X-ray beams and proton beams. The advantages and disadvantages are discussed

  10. The clinical case for proton beam therapy

    Directory of Open Access Journals (Sweden)

    Foote Robert L

    2012-10-01

    Full Text Available Abstract Over the past 20 years, several proton beam treatment programs have been implemented throughout the United States. Increasingly, the number of new programs under development is growing. Proton beam therapy has the potential for improving tumor control and survival through dose escalation. It also has potential for reducing harm to normal organs through dose reduction. However, proton beam therapy is more costly than conventional x-ray therapy. This increased cost may be offset by improved function, improved quality of life, and reduced costs related to treating the late effects of therapy. Clinical research opportunities are abundant to determine which patients will gain the most benefit from proton beam therapy. We review the clinical case for proton beam therapy. Summary sentence Proton beam therapy is a technically advanced and promising form of radiation therapy.

  11. Polarized proton beams since the ZGS

    International Nuclear Information System (INIS)

    Krisch, A.D.

    1994-01-01

    The author discusses research involving polarized proton beams since the ZGS's demise. He begins by reminding the attendee that in 1973 the ZGS accelerated the world's first high energy polarized proton beam; all in attendance at this meeting can be proud of this accomplishment. A few ZGS polarized proton beam experiments were done in the early 1970's; then from about 1976 until 1 October 1979, the majority of the ZGS running time was polarized running. A great deal of fundamental physics was done with the polarized beam when the ZGS ran as a dedicated polarized proton beam from about Fall 1977 until it shut down on 1 October 1979. The newly created polarization enthusiats then dispersed; some spread polarized seeds al over the world by polarizing beams elsewhere; some wound up running the High Energy and SSC programs at DOE

  12. Fan-beam intensity modulated proton therapy.

    Science.gov (United States)

    Hill, Patrick; Westerly, David; Mackie, Thomas

    2013-11-01

    This paper presents a concept for a proton therapy system capable of delivering intensity modulated proton therapy using a fan beam of protons. This system would allow present and future gantry-based facilities to deliver state-of-the-art proton therapy with the greater normal tissue sparing made possible by intensity modulation techniques. A method for producing a divergent fan beam of protons using a pair of electromagnetic quadrupoles is described and particle transport through the quadrupole doublet is simulated using a commercially available software package. To manipulate the fan beam of protons, a modulation device is developed. This modulator inserts or retracts acrylic leaves of varying thickness from subsections of the fan beam. Each subsection, or beam channel, creates what effectively becomes a beam spot within the fan area. Each channel is able to provide 0-255 mm of range shift for its associated beam spot, or stop the beam and act as an intensity modulator. Results of particle transport simulations through the quadrupole system are incorporated into the MCNPX Monte Carlo transport code along with a model of the range and intensity modulation device. Several design parameters were investigated and optimized, culminating in the ability to create topotherapy treatment plans using distal-edge tracking on both phantom and patient datasets. Beam transport calculations show that a pair of electromagnetic quadrupoles can be used to create a divergent fan beam of 200 MeV protons over a distance of 2.1 m. The quadrupole lengths were 30 and 48 cm, respectively, with transverse field gradients less than 20 T/m, which is within the range of water-cooled magnets for the quadrupole radii used. MCNPX simulations of topotherapy treatment plans suggest that, when using the distal edge tracking delivery method, many delivery angles are more important than insisting on narrow beam channel widths in order to obtain conformal target coverage. Overall, the sharp distal

  13. External proton and Li beams

    International Nuclear Information System (INIS)

    Schuff, Juan A.; Burlon, Alejandro A.; Debray, Mario E.; Kesque, Jose M.; Kreiner, Andres J.; Stoliar, Pablo A.; Naab, Fabian; Ozafran, Mabel J.; Vazquez, Monica E.; Perez de la Hoz, A.; Somacal, Hector; Valda, Alejandro; Canevas, S.; Ruffolo, M.; Tasat, D.R.; Muhlmann, M. C.

    2000-01-01

    In the frame of a feasibility study to introduce proton therapy in Argentina in a collaborative agreement between the Physics and Radiobiology Departments of the National Atomic Energy Commission or Argentina and the Centre de Protontherapie de Orsay, France, external proton and Li beams were produced at the TANDAR accelerator in Buenos Aires. The specific aim of this work was to start radiobiology studies on cell cultures and small laboratory animals. In particular we seek to determine here the relative biological effectiveness, RBE, for proton and Li beams as a function of energy for different tumor and normal cell lines. The 24 MeV proton beam was diffused using a 25 μm gold foil and extracted through a Kapton window to obtain a homogeneous field (constant to 95%) of about 7 cm in diameter. Measurements were carried out with quasi-monoenergetic beams (of 20.2 ± 0.07 MeV, 2.9 ± 0.10 MeV y 1.5 ± 0.1 MeV for protons and 21.4 ± 0.4 MeV for Lithium). Proton fluence and Bragg peaks were measured. The dose delivered in each case was monitored on-line with a calibrated transmission ionization chamber. Three cell lines PDV, PDVC 57 and V 79 (as a reference) were irradiated with γ-rays, proton and lithium beams with linear energy transfer (LET) from 2 to 100 keV/μm. RBE values in the range of 1.2-5.9 were obtained. In addition preliminary studies on chromosomal aberrations and viability of alveolar macrophages were carried out. (author)

  14. Proton beam therapy how protons are revolutionizing cancer treatment

    CERN Document Server

    Yajnik, Santosh

    2013-01-01

    Proton beam therapy is an emerging technology with promise of revolutionizing the treatment of cancer. While nearly half of all patients diagnosed with cancer in the US receive radiation therapy, the majority is delivered via electron accelerators, where photons are used to irradiate cancerous tissue. Because of the physical properties of photon beams, photons may deposit energy along their entire path length through the body. On the other hand, a proton beam directed at a tumor travels in a straight trajectory towards its target, gives off most of its energy at a defined depth called the Bragg peak, and then stops. While photons often deposit more energy within the healthy tissues of the body than within the cancer itself, protons can deposit most of their cancer-killing energy within the area of the tumor. As a result, in the properly selected patients, proton beam therapy has the ability to improve cure rates by increasing the dose delivered to the tumor and simultaneously reduce side-effects by decreasing...

  15. Method and apparatus for laser-controlled proton beam radiology

    Science.gov (United States)

    Johnstone, Carol J.

    1998-01-01

    A proton beam radiology system provides cancer treatment and proton radiography. The system includes an accelerator for producing an H.sup.- beam and a laser source for generating a laser beam. A photodetachment module is located proximate the periphery of the accelerator. The photodetachment module combines the H.sup.- beam and laser beam to produce a neutral beam therefrom within a subsection of the H.sup.- beam. The photodetachment module emits the neutral beam along a trajectory defined by the laser beam. The photodetachment module includes a stripping foil which forms a proton beam from the neutral beam. The proton beam is delivered to a conveyance segment which transports the proton beam to a patient treatment station. The photodetachment module further includes a laser scanner which moves the laser beam along a path transverse to the cross-section of the H.sup.- beam in order to form the neutral beam in subsections of the H.sup.- beam. As the scanning laser moves across the H.sup.- beam, it similarly varies the trajectory of the proton beam emitted from the photodetachment module and in turn varies the target location of the proton beam upon the patient. Intensity modulation of the proton beam can also be achieved by controlling the output of the laser.

  16. Proton beam characterization by proton-induced acoustic emission: simulation studies

    International Nuclear Information System (INIS)

    Jones, K C; Witztum, A; Avery, S; Sehgal, C M

    2014-01-01

    Due to their Bragg peak, proton beams are capable of delivering a targeted dose of radiation to a narrow volume, but range uncertainties currently limit their accuracy. One promising beam characterization technique, protoacoustic range verification, measures the acoustic emission generated by the proton beam. We simulated the pressure waves generated by proton radiation passing through water. We observed that the proton-induced acoustic signal consists of two peaks, labeled α and γ, with two originating sources. The α acoustic peak is generated by the pre-Bragg peak heated region whereas the source of the γ acoustic peak is the proton Bragg peak. The arrival time of the α and γ peaks at a transducer reveals the distance from the beam propagation axis and Bragg peak center, respectively. The maximum pressure is not observed directly above the Bragg peak due to interference of the acoustic signals. Range verification based on the arrival times is shown to be more effective than determining the Bragg peak position based on pressure amplitudes. The temporal width of the α and γ peaks are linearly proportional to the beam diameter and Bragg peak width, respectively. The temporal separation between compression and rarefaction peaks is proportional to the spill time width. The pressure wave expected from a spread out Bragg peak dose is characterized. The simulations also show that acoustic monitoring can verify the proton beam dose distribution and range by characterizing the Bragg peak position to within ∼1 mm. (paper)

  17. Laser Compton polarimetry of proton beams

    International Nuclear Information System (INIS)

    Stillman, A.

    1995-01-01

    A need exists for non-destructive polarization measurements of the polarized proton beams in the AGS and, in the future, in RHIC. One way to make such measurements is to scatter photons from the polarized beams. Until now, such measurements were impossible because of the extremely low Compton scattering cross section from protons. Modern lasers now can provide enough photons per laser pulse not only to scatter from proton beams but also, at least in RHIC, to analyze their polarization

  18. An online, energy-resolving beam profile detector for laser-driven proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Metzkes, J.; Rehwald, M.; Obst, L.; Schramm, U. [Helmholtz-Zentrum Dresden–Rossendorf (HZDR), Bautzner Landstr. 400, 01328 Dresden (Germany); Technische Universität Dresden, 01062 Dresden (Germany); Zeil, K.; Kraft, S. D.; Sobiella, M.; Schlenvoigt, H.-P. [Helmholtz-Zentrum Dresden–Rossendorf (HZDR), Bautzner Landstr. 400, 01328 Dresden (Germany); Karsch, L. [OncoRay-National Center for Radiation Research in Oncology, Technische Universität Dresden, 01307 Dresden (Germany)

    2016-08-15

    In this paper, a scintillator-based online beam profile detector for the characterization of laser-driven proton beams is presented. Using a pixelated matrix with varying absorber thicknesses, the proton beam is spatially resolved in two dimensions and simultaneously energy-resolved. A thin plastic scintillator placed behind the absorber and read out by a CCD camera is used as the active detector material. The spatial detector resolution reaches down to ∼4 mm and the detector can resolve proton beam profiles for up to 9 proton threshold energies. With these detector design parameters, the spatial characteristics of the proton distribution and its cut-off energy can be analyzed online and on-shot under vacuum conditions. The paper discusses the detector design, its characterization and calibration at a conventional proton source, as well as the first detector application at a laser-driven proton source.

  19. Design Study for Pulsed Proton Beam Generation

    Directory of Open Access Journals (Sweden)

    Han-Sung Kim

    2016-02-01

    Full Text Available Fast neutrons with a broad energy spectrum, with which it is possible to evaluate nuclear data for various research fields such as medical applications and the development of fusion reactors, can be generated by irradiating proton beams on target materials such as beryllium. To generate short-pulse proton beam, we adopted a deflector and slit system. In a simple deflector with slit system, most of the proton beam is blocked by the slit, especially when the beam pulse width is short. Therefore, the available beam current is very low, which results in low neutron flux. In this study, we proposed beam modulation using a buncher cavity to increase the available beam current. The ideal field pattern for the buncher cavity is sawtooth. To make the field pattern similar to a sawtooth waveform, a multiharmonic buncher was adopted. The design process for the multiharmonic buncher includes a beam dynamics calculation and three-dimensional electromagnetic simulation. In addition to the system design for pulsed proton generation, a test bench with a microwave ion source is under preparation to test the performance of the system. The design study results concerning the pulsed proton beam generation and the test bench preparation with some preliminary test results are presented in this paper.

  20. Proton-beam energy analyzer

    International Nuclear Information System (INIS)

    Belan, V.N.; Bolotin, L.I.; Kiselev, V.A.; Linnik, A.F.; Uskov, V.V.

    1989-01-01

    The authors describe a magnetic analyzer for measurement of proton-beam energy in the range from 100 keV to 25 MeV. The beam is deflected in a uniform transverse magnetic field and is registered by photographing a scintillation screen. The energy spectrum of the beam is constructed by microphotometry of the photographic film

  1. The measurement of proton stopping power using proton-cone-beam computed tomography

    International Nuclear Information System (INIS)

    Zygmanski, P.; Rabin, M.S.Z.; Gall, K.P.; Rosenthal, S.J.

    2000-01-01

    A cone-beam computed tomography (CT) system utilizing a proton beam has been developed and tested. The cone beam is produced by scattering a 160 MeV proton beam with a modifier that results in a signal in the detector system, which decreases monotonically with depth in the medium. The detector system consists of a Gd 2 O 2 S:Tb intensifying screen viewed by a cooled CCD camera. The Feldkamp-Davis-Kress cone-beam reconstruction algorithm is applied to the projection data to obtain the CT voxel data representing proton stopping power. The system described is capable of reconstructing data over a 16x16x16cm 3 volume into 512x512x512 voxels. A spatial and contrast resolution phantom was scanned to determine the performance of the system. Spatial resolution is significantly degraded by multiple Coulomb scattering effects. Comparison of the reconstructed proton CT values with x-ray CT derived proton stopping powers shows that there may be some advantage to obtaining stopping powers directly with proton CT. The system described suggests a possible practical method of obtaining this measurement in vivo. (author)

  2. External proton and Li beams; Haces externos de protones y litios

    Energy Technology Data Exchange (ETDEWEB)

    Schuff, Juan A; Burlon, Alejandro A; Debray, Mario E; Kesque, Jose M; Kreiner, Andres J; Stoliar, Pablo A; Naab, Fabian; Ozafran, Mabel J; Vazquez, Monica E [Comision Nacional de Energia Atomica, General San Martin (Argentina). Dept. de Fisica; Policastro, Lucia L; Duran, Hebe; Molinari, Beatriz L; O' Connor, Silvia E; Saint-Martin, Maria L.G.; Palmieri, Monica; Bernaola, Omar A; Opezzo, Oscar J [Comision Nacional de Energia Atomica, General San Martin (Argentina). Dept. de Radiobiologia; Mazal, A; Favaudon, F; Henry, Y [Institut Curie, 75 - Paris (France); Perez de la Hoz, A.; Somacal, Hector; Valda, Alejandro; Canevas, S; Ruffolo, M; Tasat, D R [Universidad Nacional de General San Martin, Villa Ballester (Argentina). Escuela de Ciencia y Tecnologia; Davidson, Miguel; Davidson, Jorge [Buenos Aires Univ. (Argentina). Dept. de Fisica; Delacroix, S; Nauraye, C; Brune, E; Gautier, C; Habrand, J L [Centre de Protontherapie, 91 - Orsay (France); Muhlmann, M C [Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Buenos Aires (Argentina)

    2000-07-01

    In the frame of a feasibility study to introduce proton therapy in Argentina in a collaborative agreement between the Physics and Radiobiology Departments of the National Atomic Energy Commission or Argentina and the Centre de Protontherapie de Orsay, France, external proton and Li beams were produced at the TANDAR accelerator in Buenos Aires. The specific aim of this work was to start radiobiology studies on cell cultures and small laboratory animals. In particular we seek to determine here the relative biological effectiveness, RBE, for proton and Li beams as a function of energy for different tumor and normal cell lines. The 24 MeV proton beam was diffused using a 25 {mu}m gold foil and extracted through a Kapton window to obtain a homogeneous field (constant to 95%) of about 7 cm in diameter. Measurements were carried out with quasi-monoenergetic beams (of 20.2 {+-} 0.07 MeV, 2.9 {+-} 0.10 MeV y 1.5 {+-} 0.1 MeV for protons and 21.4 {+-} 0.4 MeV for Lithium). Proton fluence and Bragg peaks were measured. The dose delivered in each case was monitored on-line with a calibrated transmission ionization chamber. Three cell lines PDV, PDVC 57 and V 79 (as a reference) were irradiated with {gamma}-rays, proton and lithium beams with linear energy transfer (LET) from 2 to 100 keV/{mu}m. RBE values in the range of 1.2-5.9 were obtained. In addition preliminary studies on chromosomal aberrations and viability of alveolar macrophages were carried out. (author)

  3. Validation of nuclear models in Geant4 using the dose distribution of a 177 MeV proton pencil beam

    International Nuclear Information System (INIS)

    Hall, David C; Paganetti, Harald; Makarova, Anastasia; Gottschalk, Bernard

    2016-01-01

    A proton pencil beam is associated with a surrounding low-dose envelope, originating from nuclear interactions. It is important for treatment planning systems to accurately model this envelope when performing dose calculations for pencil beam scanning treatments, and Monte Carlo (MC) codes are commonly used for this purpose. This work aims to validate the nuclear models employed by the Geant4 MC code, by comparing the simulated absolute dose distribution to a recent experiment of a 177 MeV proton pencil beam stopping in water. Striking agreement is observed over five orders of magnitude, with both the shape and normalisation well modelled. The normalisations of two depth dose curves are lower than experiment, though this could be explained by an experimental positioning error. The Geant4 neutron production model is also verified in the distal region. The entrance dose is poorly modelled, suggesting an unaccounted upstream source of low-energy protons. Recommendations are given for a follow-up experiment which could resolve these issues. (note)

  4. Polarizing a stored proton beam by spin-flip?

    International Nuclear Information System (INIS)

    Oellers, Dieter Gerd Christian

    2010-01-01

    The present thesis discusses the extraction of the electron-proton spin-flip cross-section. The experimental setup, the data analysis and the results are pictured in detail. The proton is described by a QCD-based parton model. In leading twist three functions are needed. The quark distribution, the helicity distribution and the transversity distribution. While the first two are well-known, the transversity distribution is largely unknown. A self-sufficient measurement of the transversity is possible in double polarized proton-antiproton scattering. This rises the need of a polarized antiproton beam. So far spin filtering is the only tested method to produce a polarized proton beam, which may be capable to hold also for antiprotons. In-situ polarization build-up of a stored beam either by selective removal or by spin-flip of a spin-(1)/(2) beam is mathematically described. A high spin-flip cross-section would create an effective method to produce a polarized antiproton beam by polarized positrons. Prompted by conflicting calculations, a measurement of the spin-flip cross-section in low-energy electron-proton scattering was carried out. This experiment uses the electron beam of the electron cooler at COSY as an electron target. The depolarization of the stored proton beam is detected. An overview of the experiment is followed by detailed descriptions of the cycle setup, of the electron target and the ANKE silicon tracking telescopes acting as a beam polarimeter. Elastic protondeuteron scattering is the analyzing reaction. The event selection is depicted and the beam polarization is calculated. Upper limits of the two electron-proton spin-flip cross-sections σ parallel and σ perpendicular to are deduced using the likelihood method. (orig.)

  5. Antimatter production in proton-proton and heavy-ion collisions at ultrarelativistic energies

    International Nuclear Information System (INIS)

    Cleymans, J.; Kabana, S.; Kraus, I.; Oeschler, H.; Redlich, K.; Sharma, N.

    2011-01-01

    One of the striking features of particle production at high beam energies is the near-equal abundance of matter and antimatter in the central rapidity region. In this paper we study how this symmetry is reached as the beam energy is increased. In particular, we quantify explicitly the energy dependence of the approach to matter-antimatter symmetry in proton-proton and in heavy-ion collisions. Expectations are presented also for the production of more complex forms of antimatter such as antihypernuclei.

  6. Proton beam writing of passive waveguides in PMMA

    International Nuclear Information System (INIS)

    Sum, T.C.; Bettiol, A.A.; Seng, H.L.; Rajta, I.; Kan, J.A. van; Watt, F.

    2003-01-01

    Symmetric y-branch buried channel waveguides in poly-methylmethacrylate (PMMA) were fabricated by proton beam writing using a focused sub-micron beam of 1.5 and 2.0 MeV protons with a dose ranging from 25 to 160 nC/mm 2 (i.e. ∼1.6 x 10 13 to 1.0 x 10 14 particles/cm 2 ) and beam currents of approximately 5-10 pA. The proton beam modifies the PMMA (i.e. changes the refractive index), forming buried channel waveguides near the end of range. The buried channel waveguides were end-coupled with monochromatic light (633 nm) and the transmitted intensity profiles were measured, indicating an intensity distribution of 0.45/0.55 from each branch. The surface compaction of the PMMA as a result of the irradiation for doses up to 160 nC/mm 2 was also investigated. From these investigations, the optimal fabrication conditions for proton beam writing of PMMA were established. Waveguides of arbitrary design can be easily fabricated using proton beam writing, making the technique ideal for the rapid prototyping of optical circuits

  7. Beam heating in solar flares - Electrons or protons?

    International Nuclear Information System (INIS)

    Brown, J.C.; Karlicky, M.; Mackinnon, A.L.; Van Den Oord, G.H.J.

    1990-01-01

    The current status of electron and proton beam models as candidates for the impulsive phase heating of solar flares is discussed in relation to observational constants and theoretical difficulties. It is concluded that, while the electron beam model for flare heating still faces theoretical and observational problems, the problems faced by low and high energy proton beam models are no less serious, and there are facets of proton models which have not yet been studied. At the present, the electron beam model remains the most viable and best developed of heating model candidates. 58 refs

  8. Polarizing a stored proton beam by spin-flip?

    Energy Technology Data Exchange (ETDEWEB)

    Oellers, Dieter Gerd Christian

    2010-04-15

    The present thesis discusses the extraction of the electron-proton spin-flip cross-section. The experimental setup, the data analysis and the results are pictured in detail. The proton is described by a QCD-based parton model. In leading twist three functions are needed. The quark distribution, the helicity distribution and the transversity distribution. While the first two are well-known, the transversity distribution is largely unknown. A self-sufficient measurement of the transversity is possible in double polarized proton-antiproton scattering. This rises the need of a polarized antiproton beam. So far spin filtering is the only tested method to produce a polarized proton beam, which may be capable to hold also for antiprotons. In-situ polarization build-up of a stored beam either by selective removal or by spin-flip of a spin-(1)/(2) beam is mathematically described. A high spin-flip cross-section would create an effective method to produce a polarized antiproton beam by polarized positrons. Prompted by conflicting calculations, a measurement of the spin-flip cross-section in low-energy electron-proton scattering was carried out. This experiment uses the electron beam of the electron cooler at COSY as an electron target. The depolarization of the stored proton beam is detected. An overview of the experiment is followed by detailed descriptions of the cycle setup, of the electron target and the ANKE silicon tracking telescopes acting as a beam polarimeter. Elastic protondeuteron scattering is the analyzing reaction. The event selection is depicted and the beam polarization is calculated. Upper limits of the two electron-proton spin-flip cross-sections {sigma} {sub parallel} and {sigma} {sub perpendicular} {sub to} are deduced using the likelihood method. (orig.)

  9. Laser-accelerated proton beams as a new particle source

    Energy Technology Data Exchange (ETDEWEB)

    Nuernberg, Frank

    2010-11-15

    The framework of this thesis is the investigation of the generation of proton beams using high-intensity laser pulses. In this work, an experimental method to fully reconstruct laser-accelerated proton beam parameters, called radiochromic film imaging spectroscopy (RIS), was developed. Since the proton beam expansion is a plasma expansion with accompanying electrons, a low-energy electron spectrometer was developed, built and tested to study the electron distribution matching to the proton beam energy distribution. Two experiments were carried out at the VULCAN Petawatt laser with the aim of showing dynamic control and enhancement of proton acceleration using multiple or defocused laser pulses. Irradiating the target with a long pulse, low-intensity laser (10{sup 12} W/cm{sup 2}) prior to the main pulse ({proportional_to}ns), an optimum pre-plasma density scale length of 60 {mu}m is generated leading to an enhancement of the maximum proton energy ({proportional_to}25%), the proton flux (factor of 3) and the beam uniformity. Proton beams were generated more efficiently than previously by driving thinner target foils at a lower intensity over a large area. The optimum condition was a 2 {mu}m foil irradiated with an intensity of 10{sup 19} W/cm{sup 2} onto a 60 {mu}m spot. Laser to proton beam efficiencies of 7.8% have been achieved (2.2% before) - one of the highest conversion efficiencies ever achieved. In the frame of this work, two separate experiments at the TRIDENT laser system have shown that these laser-accelerated proton beams, with their high number of particles in a short pulse duration, are well-suited for creating isochorically heated matter in extreme conditions. Besides the manipulation of the proton beam parameters directly during the generation, the primary aim of this thesis was the capture, control and transport of laser-accelerated proton beams by a solenoidal magnetic field lense for further purpose. In a joint project proposal, the laser and

  10. Laser-accelerated proton beams as a new particle source

    International Nuclear Information System (INIS)

    Nuernberg, Frank

    2010-01-01

    The framework of this thesis is the investigation of the generation of proton beams using high-intensity laser pulses. In this work, an experimental method to fully reconstruct laser-accelerated proton beam parameters, called radiochromic film imaging spectroscopy (RIS), was developed. Since the proton beam expansion is a plasma expansion with accompanying electrons, a low-energy electron spectrometer was developed, built and tested to study the electron distribution matching to the proton beam energy distribution. Two experiments were carried out at the VULCAN Petawatt laser with the aim of showing dynamic control and enhancement of proton acceleration using multiple or defocused laser pulses. Irradiating the target with a long pulse, low-intensity laser (10 12 W/cm 2 ) prior to the main pulse (∝ns), an optimum pre-plasma density scale length of 60 μm is generated leading to an enhancement of the maximum proton energy (∝25%), the proton flux (factor of 3) and the beam uniformity. Proton beams were generated more efficiently than previously by driving thinner target foils at a lower intensity over a large area. The optimum condition was a 2 μm foil irradiated with an intensity of 10 19 W/cm 2 onto a 60 μm spot. Laser to proton beam efficiencies of 7.8% have been achieved (2.2% before) - one of the highest conversion efficiencies ever achieved. In the frame of this work, two separate experiments at the TRIDENT laser system have shown that these laser-accelerated proton beams, with their high number of particles in a short pulse duration, are well-suited for creating isochorically heated matter in extreme conditions. Besides the manipulation of the proton beam parameters directly during the generation, the primary aim of this thesis was the capture, control and transport of laser-accelerated proton beams by a solenoidal magnetic field lense for further purpose. In a joint project proposal, the laser and plasma physics group of the Technische Universitat

  11. Medipix2 as a tool for proton beam characterization

    Science.gov (United States)

    Bisogni, M. G.; Cirrone, G. A. P.; Cuttone, G.; Del Guerra, A.; Lojacono, P.; Piliero, M. A.; Romano, F.; Rosso, V.; Sipala, V.; Stefanini, A.

    2009-08-01

    Proton therapy is a technique used to deliver a highly accurate and effective dose for the treatment of a variety of tumor diseases. The possibility to have an instrument able to give online information could reduce the time necessary to characterize the proton beam. To this aim we propose a detection system for online proton beam characterization based on the Medipix2 chip. Medipix2 is a detection system based on a single event counter read-out chip, bump-bonded to silicon pixel detector. The read-out chip is a matrix of 256×256 cells, 55×55 μm 2 each. To demonstrate the capabilities of Medipix2 as a proton detector, we have used a 62 MeV flux proton beam at the CATANA beam line of the LNS-INFN laboratory. The measurements performed confirmed the good imaging performances of the Medipix2 system also for the characterization of proton beams.

  12. Medipix2 as a tool for proton beam characterization

    Energy Technology Data Exchange (ETDEWEB)

    Bisogni, M.G. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy); Cirrone, G.A.P.; Cuttone, G. [INFN Laboratori Nazionali del Sud, Catania (Italy); Del Guerra, A. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy); Lojacono, P. [INFN Laboratori Nazionali del Sud, Catania (Italy); Piliero, M.A. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy); Romano, F. [INFN Laboratori Nazionali del Sud, Catania (Italy); Rosso, V. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy)], E-mail: valeria.rosso@pi.infn.it; Sipala, V. [Department of Physics and Astronomy, University of Catania and INFN Sezione di Catania, Catania (Italy); Stefanini, A. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy)

    2009-08-01

    Proton therapy is a technique used to deliver a highly accurate and effective dose for the treatment of a variety of tumor diseases. The possibility to have an instrument able to give online information could reduce the time necessary to characterize the proton beam. To this aim we propose a detection system for online proton beam characterization based on the Medipix2 chip. Medipix2 is a detection system based on a single event counter read-out chip, bump-bonded to silicon pixel detector. The read-out chip is a matrix of 256x256 cells, 55x55 {mu}m{sup 2} each. To demonstrate the capabilities of Medipix2 as a proton detector, we have used a 62 MeV flux proton beam at the CATANA beam line of the LNS-INFN laboratory. The measurements performed confirmed the good imaging performances of the Medipix2 system also for the characterization of proton beams.

  13. Medipix2 as a tool for proton beam characterization

    International Nuclear Information System (INIS)

    Bisogni, M.G.; Cirrone, G.A.P.; Cuttone, G.; Del Guerra, A.; Lojacono, P.; Piliero, M.A.; Romano, F.; Rosso, V.; Sipala, V.; Stefanini, A.

    2009-01-01

    Proton therapy is a technique used to deliver a highly accurate and effective dose for the treatment of a variety of tumor diseases. The possibility to have an instrument able to give online information could reduce the time necessary to characterize the proton beam. To this aim we propose a detection system for online proton beam characterization based on the Medipix2 chip. Medipix2 is a detection system based on a single event counter read-out chip, bump-bonded to silicon pixel detector. The read-out chip is a matrix of 256x256 cells, 55x55 μm 2 each. To demonstrate the capabilities of Medipix2 as a proton detector, we have used a 62 MeV flux proton beam at the CATANA beam line of the LNS-INFN laboratory. The measurements performed confirmed the good imaging performances of the Medipix2 system also for the characterization of proton beams.

  14. Optimization of laser accelerated proton beams for possible applications

    Energy Technology Data Exchange (ETDEWEB)

    Al-Omari, Husam [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Planckstrasse 1, 64291 Darmstadt (Germany); Collaboration: LIGHT-Collaboration

    2013-07-01

    Optimization of transported proton beams through a pulsed solenoid in the laser proton experiment LIGHT at GSI has been studied numerically. TraceWin, SRIM and ATIMA codes were employed for this study with an initial distribution generated by MATLAB program fitted to Phelix measured data. Two individual tools have been used to produce protons beam as a later beam source: an aperture located at the solenoid focal spot as energy selection tool; and a scattering foil at a suitable position in the beam path that smoothens the simulated radial energy imprint on the beam profile. The simulation results show that the proton energy spectrum is filtered by the aperture and the radial energy correlation is smoothened.

  15. Hyperon beams as a source of polarized protons

    International Nuclear Information System (INIS)

    Underwood, D.G.

    1978-01-01

    A high energy polarized proton beam which would utilize lambda decays as a source of polarized protons was proposed. We discuss the operation of such a beam and related physics experiments. 12 references

  16. Beam collimation and energy spectrum compression of laser-accelerated proton beams using solenoid field and RF cavity

    Energy Technology Data Exchange (ETDEWEB)

    Teng, J.; Gu, Y.Q., E-mail: tengjian@mail.ustc.edu.cn; Zhu, B.; Hong, W.; Zhao, Z.Q.; Zhou, W.M.; Cao, L.F.

    2013-11-21

    This paper presents a new method of laser produced proton beam collimation and spectrum compression using a combination of a solenoid field and a RF cavity. The solenoid collects laser-driven protons efficiently within an angle that is smaller than 12 degrees because it is mounted few millimeters from the target, and collimates protons with energies around 2.3 MeV. The collimated proton beam then passes through a RF cavity to allow compression of the spectrum. Particle-in-cell (PIC) simulations demonstrate the proton beam transport in the solenoid and RF electric fields. Excellent energy compression and collection efficiency of protons are presented. This method for proton beam optimization is suitable for high repetition-rate laser acceleration proton beams, which could be used as an injector for a conventional proton accelerator.

  17. Beam collimation and energy spectrum compression of laser-accelerated proton beams using solenoid field and RF cavity

    Science.gov (United States)

    Teng, J.; Gu, Y. Q.; Zhu, B.; Hong, W.; Zhao, Z. Q.; Zhou, W. M.; Cao, L. F.

    2013-11-01

    This paper presents a new method of laser produced proton beam collimation and spectrum compression using a combination of a solenoid field and a RF cavity. The solenoid collects laser-driven protons efficiently within an angle that is smaller than 12 degrees because it is mounted few millimeters from the target, and collimates protons with energies around 2.3 MeV. The collimated proton beam then passes through a RF cavity to allow compression of the spectrum. Particle-in-cell (PIC) simulations demonstrate the proton beam transport in the solenoid and RF electric fields. Excellent energy compression and collection efficiency of protons are presented. This method for proton beam optimization is suitable for high repetition-rate laser acceleration proton beams, which could be used as an injector for a conventional proton accelerator.

  18. Beam collimation and energy spectrum compression of laser-accelerated proton beams using solenoid field and RF cavity

    International Nuclear Information System (INIS)

    Teng, J.; Gu, Y.Q.; Zhu, B.; Hong, W.; Zhao, Z.Q.; Zhou, W.M.; Cao, L.F.

    2013-01-01

    This paper presents a new method of laser produced proton beam collimation and spectrum compression using a combination of a solenoid field and a RF cavity. The solenoid collects laser-driven protons efficiently within an angle that is smaller than 12 degrees because it is mounted few millimeters from the target, and collimates protons with energies around 2.3 MeV. The collimated proton beam then passes through a RF cavity to allow compression of the spectrum. Particle-in-cell (PIC) simulations demonstrate the proton beam transport in the solenoid and RF electric fields. Excellent energy compression and collection efficiency of protons are presented. This method for proton beam optimization is suitable for high repetition-rate laser acceleration proton beams, which could be used as an injector for a conventional proton accelerator

  19. Fan beam intensity modulated proton therapy

    Science.gov (United States)

    Hill, Patrick M.

    A fan beam proton therapy is developed which delivers intensity modulated proton therapy using distal edge tracking. The system may be retrofit onto existing proton therapy gantries without alterations to infrastructure in order to improve treatments through intensity modulation. A novel range and intensity modulation system is designed using acrylic leaves that are inserted or retracted from subsections of the fan beam. Leaf thicknesses are chosen in a base-2 system and motivated in a binary manner. Dose spots from individual beam channels range between 1 and 5 cm. Integrated collimators attempting to limit crosstalk among beam channels are investigated, but found to be inferior to uncollimated beam channel modulators. A treatment planning system performing data manipulation in MATLAB and dose calculation in MCNPX is developed. Beamlet dose is calculated on patient CT data and a fan beam source is manually defined to produce accurate results. An energy deposition tally follows the CT grid, allowing straightforward registration of dose and image data. Simulations of beam channels assume that a beam channel either delivers dose to a distal edge spot or is intensity modulated. A final calculation is performed separately to determine the deliverable dose accounting for all sources of scatter. Treatment plans investigate the effects that varying system parameters have on dose distributions. Beam channel apertures may be as large as 20 mm because the sharp distal falloff characteristic of proton dose provides sufficient intensity modulation to meet dose objectives, even in the presence of coarse lateral resolution. Dose conformity suffers only when treatments are delivered from less than 10 angles. Jaw widths of 1--2 cm produce comparable dose distributions, but a jaw width of 4 cm produces unacceptable target coverage when maintaining critical structure avoidance. Treatment time for a prostate delivery is estimated to be on the order of 10 minutes. Neutron production

  20. Formation of an intense proton beam of microsecond duration

    Energy Technology Data Exchange (ETDEWEB)

    Engelko, V [Efremov Inst. of Electrophysical Apparatus, St. Petersburg (Russian Federation); Giese, H; Schalk, S [Forschungszentrum Karlsruhe (Germany)

    1997-12-31

    The proton beam facility PROFA serves as a test installation for ion source development and beam transport optimization for an intense pulsed proton beam of low kinetic energy, envisaged for ITER divertor load simulation. The present state of the investigations is discussed with emphasis on the diode operation parameters, beam divergence and beam transport efficiency. (author). 7 figs., 5 refs.

  1. Splitting of high power, cw proton beams

    Directory of Open Access Journals (Sweden)

    Alberto Facco

    2007-09-01

    Full Text Available A simple method for splitting a high power, continuous wave (cw proton beam in two or more branches with low losses has been developed in the framework of the EURISOL (European Isotope Separation On-Line Radioactive Ion Beam Facility design study. The aim of the system is to deliver up to 4 MW of H^{-} beam to the main radioactive ion beam production target, and up to 100 kW of proton beams to three more targets, simultaneously. A three-step method is used, which includes magnetic neutralization of a fraction of the main H^{-} beam, magnetic splitting of H^{-} and H^{0}, and stripping of H^{0} to H^{+}. The method allows slow raising and individual fine adjustment of the beam intensity in each branch.

  2. Compensation techniques in NIRS proton beam radiotherapy

    International Nuclear Information System (INIS)

    Akanuma, A.; Majima, H.; Furukawa, S.

    1982-01-01

    Proton beam has the dose distribution advantage in radiation therapy, although it has little advantage in biological effects. One of the best advantages is its sharp fall off of dose after the peak. With proton beam, therefore, the dose can be given just to cover a target volume and potentially no dose is delivered thereafter in the beam direction. To utilize this advantage, bolus techniques in conjunction with CT scanning are employed in NIRS proton beam radiation therapy planning. A patient receives CT scanning first so that the target volume can be clearly marked and the radiation direction and fixation method can be determined. At the same time bolus dimensions are calculated. The bolus frames are made with dental paraffin sheets according to the dimensions. The paraffin frame is replaced with dental resin. Alginate (a dental impression material with favorable physical density and skin surface contact) is now employed for the bolus material. With fixation device and bolus on, which are constructed individually, the patient receives CT scanning again prior to a proton beam treatment in order to prove the devices are suitable. Alginate has to be poured into the frame right before each treatments. Further investigations are required to find better bolus materials and easier construction methods

  3. Compensation techniques in NIRS proton beam radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Akanuma, A. (Univ. of Tokyo, Japan); Majima, H.; Furukawa, S.

    1982-09-01

    Proton beam has the dose distribution advantage in radiation therapy, although it has little advantage in biological effects. One of the best advantages is its sharp fall off of dose after the peak. With proton beam, therefore, the dose can be given just to cover a target volume and potentially no dose is delivered thereafter in the beam direction. To utilize this advantage, bolus techniques in conjunction with CT scanning are employed in NIRS proton beam radiation therapy planning. A patient receives CT scanning first so that the target volume can be clearly marked and the radiation direction and fixation method can be determined. At the same time bolus dimensions are calculated. The bolus frames are made with dental paraffin sheets according to the dimensions. The paraffin frame is replaced with dental resin. Alginate (a dental impression material with favorable physical density and skin surface contact) is now employed for the bolus material. With fixation device and bolus on, which are constructed individually, the patient receives CT scanning again prior to a proton beam treatment in order to prove the devices are suitable. Alginate has to be poured into the frame right before each treatments. Further investigations are required to find better bolus materials and easier construction methods.

  4. Proton beam characterization in the experimental room of the Trento Proton Therapy facility

    Science.gov (United States)

    Tommasino, F.; Rovituso, M.; Fabiano, S.; Piffer, S.; Manea, C.; Lorentini, S.; Lanzone, S.; Wang, Z.; Pasini, M.; Burger, W. J.; La Tessa, C.; Scifoni, E.; Schwarz, M.; Durante, M.

    2017-10-01

    As proton therapy is becoming an established treatment methodology for cancer patients, the number of proton centres is gradually growing worldwide. The economical effort for building these facilities is motivated by the clinical aspects, but might be also supported by the potential relevance for the research community. Experiments with high-energy protons are needed not only for medical physics applications, but represent also an essential part of activities dedicated to detector development, space research, radiation hardness tests, as well as of fundamental research in nuclear and particle physics. Here we present the characterization of the beam line installed in the experimental room of the Trento Proton Therapy Centre (Italy). Measurements of beam spot size and envelope, range verification and proton flux were performed in the energy range between 70 and 228 MeV. Methods for reducing the proton flux from typical treatments values of 106-109 particles/s down to 101-105 particles/s were also investigated. These data confirm that a proton beam produced in a clinical centre build by a commercial company can be exploited for a broad spectrum of experimental activities. The results presented here will be used as a reference for future experiments.

  5. Proton GE/GM from beam-target asymmetry

    International Nuclear Information System (INIS)

    Mark Jones; Aram Aghalaryan; Abdellah Ahmidouch; Razmik Asaturyan; Frederic Bloch; Werner Boeglin; Peter Bosted; Cedric Carasco; Roger Carlini; Jinseok Cha; Jian-Ping Chen; Michael Christy; Leon Cole; Luminita Coman; Donald Crabb; Samuel Danagoulian; Donal Day; James Dunne; Mostafa Elaasar; Rolf Ent; Howard Fenker; Emil Frlez; David Gaskell; Liping Gan; Javier Gomez; Bitao Hu; Juerg Jourdan; Christopher Keith; Cynthia Keppel; Mahbubul Khandaker; Andreas Klein; Laird Kramer; Yongguang Liang; Jechiel Lichtenstadt; Richard Lindgren; David Mack; Paul McKee; Dustin McNulty; David Meekins; Hamlet Mkrtchyan; Rakhsha Nasseripour; Maria-Ioana Niculescu; Kristoff Normand; Blaine Norum; Dinko Pocanic; Yelena Prok; Brian Raue; Joerg Reinhold; Julie Roche; Daniela Rohe; Oscar Rondon-Aramayo; Nikolai Savvinov; Bradley Sawatzky; Mikell Seely; Ingo Sick; Karl Slifer; C. Smith; Gregory Smith; S. Stepanyan; Liguang Tang; Shigeyuki Tajima; Giuseppe Testa; William Vulcan; Kebin Wang; Glen Warren; Frank Wesselmann; Stephen Wood; Chen Yan; Lulin Yuan; Junho Yun; Markus Zeier; Hong Guo Zhu

    2006-01-01

    The ratio of the proton's electric to magnetic form factor, G E /G M , can be extracted in elastic electron-proton scattering by measuring either cross sections, beam-target asymmetry or recoil polarization. Separate determinations of G E /G M by cross sections and recoil polarization observables disagree for Q 2 > 1 (GeV/c) 2 . Measurement by a third technique might uncover an unknown systematic error in either of the previous measurements. The beam-target asymmetry has been measured for elastic electron-proton scattering at Q 2 = 1.51 (GeV/c) 2 for target spin orientation aligned perpendicular to the beam momentum direction. This is the largest Q 2 at which G E /G M has been determined by a beam-target asymmetry experiment. The result, μG E /G M = 0.884 +/- 0.027 +/- 0.029, is compared to previous world data

  6. Acceleration of polarized proton beams

    International Nuclear Information System (INIS)

    Roser, T.

    1998-01-01

    The acceleration of polarized beams in circular accelerators is complicated by the numerous depolarizing spin resonances. Using a partial Siberian snake and a rf dipole that ensure stable adiabatic spin motion during acceleration has made it possible to accelerate polarized protons to 25 GeV at the Brookhaven AGS. Full Siberian snakes are being developed for RHIC to make the acceleration of polarized protons to 250 GeV possible. A similar scheme is being studied for the 800 GeV HERA proton accelerator

  7. The Beam Profile Monitoring System for the CERN IRRAD Proton Facility

    CERN Document Server

    Ravotti, F; Glaser, M; Matli, E; Pezzullo, G; Gan, K K; Kagan, H; Smith, S; Warner, J D

    2017-01-01

    GeV/c proton beam is used. During beam steering and irradiation, the intensity and the transverse profile of the proton beam are monitored online with custom-made Beam Profile Monitor (BPM) devices. In this work, we present the design and the architecture of the IRRAD BPM system, some results on its performance with the proton beam, as well as its planned grades.

  8. Absolute measurements methods for proton beam dosimetry

    International Nuclear Information System (INIS)

    Laitano, R.F.

    1998-01-01

    A widespread interest in improving proton beam characteristics and related dosimetry became apparent in the recent years, even if the advantages of protons in radiotherapy were pointed out since 1946. The early treatments by proton beams were made for a long time on a small number of patients in very few accelerators sharing their use with nuclear-physics experiments. The first proton accelerator totally dedicated to radiotherapy was established just in 1990 at the Loma Linda Medical Center in the USA. A further reason of the slowly growing use of protons for therapy in the early years, was the lack of adequate means for accurate localization of the treatment volume. The potentialities of protons in imparting a largest part of their energy to very small volumes became exploitable only after the established clinical use of accurate imaging techniques such as based on CT, NMR, PET, etc

  9. Proton-proton colliding beam facility ISABELLE

    International Nuclear Information System (INIS)

    Hahn, H.

    1980-01-01

    This paper attempts to present the status of the ISABELLE construction project, which has the objective of building a 400 + 400 GeV proton colliding beam facility. The major technical features of the superconducting accelerators with their projected performance are described. Progress made so far, difficulties encountered, and the program until completion in 1986 is briefly reviewed

  10. SU-E-J-63: Feasibility Study of Proton Digital Tomosynthesis in Proton Beam Therapy.

    Science.gov (United States)

    Min, B; Kwak, J; Lee, J; Cho, S; Park, S; Yoo, S; Chung, K; Cho, S; Lim, Y; Shin, D; Lee, S; Kim, J

    2012-06-01

    We investigated the feasibility of proton tomosynthesis as daily positioning of patients and compared the results with photon tomosynthesis as an alternative to conventional portal imaging or on-board cone-beam computed tomography. Dedicated photon-like proton beam using the passively scattered proton beams by the cyclotron was generated for proton imaging. The eleven projections were acquired over 30 degree with 3 degree increment in order to investigate the performance of proton tomosynthesis. The cylinder blocks and resolution phantom were used to evaluate imaging performance. Resolution phantom of a cylinder of diameter 12 cm was used to investigate the reconstructed imaging characteristics. Electron density cylinder blocks with diameter of 28 mm and height of 70 mm were employed to assess the imaging quality. The solid water, breast, bone, adipose, lung, muscle, and liver, which were tissue equivalent inserts, were positioned around the resolution phantom. The images were reconstructed by projection onto convex sets (POCS) algorithm and total variation minimization (TVM) methods. The Gafchromic EBT films were utilized for measuring the photon-like proton beams as a proton detector. In addition, the photon tomosynthesis images were obtained for a comparison with proton tomosynthesis images. The same angular sampling data were acquired for both proton and photon tomosynthesis. In the resolution phantom image obtained proton tomosynthesis, down to 1.6 mm diameter rods were resolved visually, although the separation between adjacent rods was less distinct. In contrast, down to 1.2 mm diameter rods were resolved visually in the reconstructed image obtained photon tomosynthesis. Both proton and photon tomosynthesis images were similar in intensities of different density blocks. Our results demonstrated that proton tomosynthesis could make it possible to provide comparable tomography imaging to photon tomosynthesis for positioning as determined by manual registration

  11. Clinical proton dosimetry. Part 1: Beam production, beam delivery and measurement of absorbed dose

    International Nuclear Information System (INIS)

    1998-01-01

    The development of accurate and uniform standards for radiation treatment dosimetry has been a continuing effort since the earliest days of radiotherapy. This ICRU Report is intended to promote uniformity of standards that will provide a basis for world-wide comparison of clinical results and allow the development of meaningful clinical trials. This Report describes current practice in proton therapy and recommends standards for the dosimetry of proton treatments. Established proton treatment facilities might use this Report as a source of information for the maintenance of accurate standards. New facilities may build their procedures from recommendations found in this Report and planners of new facilities may examine alternatives within current practice for the production and monitoring of treatment beams. This Report includes a description of the interaction of protons with matter, various methods of beam production, the characteristics of proton beams in clinical use, current methods for beam monitoring and specific recommendations for dose calibration

  12. Proton beam therapy facility

    International Nuclear Information System (INIS)

    1984-01-01

    It is proposed to build a regional outpatient medical clinic at the Fermi National Accelerator Laboratory (Fermilab), Batavia, Illinois, to exploit the unique therapeutic characteristics of high energy proton beams. The Fermilab location for a proton therapy facility (PTF) is being chosen for reasons ranging from lower total construction and operating costs and the availability of sophisticated technical support to a location with good access to patients from the Chicago area and from the entire nation. 9 refs., 4 figs., 26 tabs

  13. Proton beam therapy facility

    Energy Technology Data Exchange (ETDEWEB)

    1984-10-09

    It is proposed to build a regional outpatient medical clinic at the Fermi National Accelerator Laboratory (Fermilab), Batavia, Illinois, to exploit the unique therapeutic characteristics of high energy proton beams. The Fermilab location for a proton therapy facility (PTF) is being chosen for reasons ranging from lower total construction and operating costs and the availability of sophisticated technical support to a location with good access to patients from the Chicago area and from the entire nation. 9 refs., 4 figs., 26 tabs.

  14. Interaction of Macro-particles with LHC proton beam

    CERN Document Server

    Zimmermann, F; Xagkoni, A

    2010-01-01

    We study the interaction of macro-particles residing inside the LHC vacuum chamber, e.g. soot or thermalinsulation fragments, with the circulating LHC proton beam. The coupled equations governing the motion and charging rate of metallic or dielectric micron-size macroparticles are solved numerically to determine the time spent by such “dust” particles close to the path of the beam as well as the resulting proton-beam losses, which could lead to a quench of superconducting magnets and, thereby, to a premature beam abort.

  15. Exposure parameters in proton beam writing for hydrogen silsesquioxane

    International Nuclear Information System (INIS)

    Kan, J.A. van; Zhang, F.; Zhang, C.; Bettiol, A.A.; Watt, F.

    2008-01-01

    In proton beam writing (PBW) a focused MeV proton beam is scanned in a predetermined pattern over a resist (e.g. PMMA, SU-8 or HSQ), which is subsequently chemically developed. In e-beam writing as well as p-beam writing the energy loss of the primary beam is dominated by energy transfer to substrate electrons. Unlike the high energy secondary electrons generated during e-beam writing the secondary electrons induced by the primary proton beam have low energy and therefore a limited range, resulting in minimal proximity effects. The low proximity effects exhibited by p-beam writing coupled with the straight trajectory and high penetration of the proton beam enables the production of high aspect ratio, high density 3D micro and nanostructures with well defined smooth side walls to be directly written into resist materials. This property together with the stability and focusing power of the end station ensures even exposures with nm smoothness and allows fabrication of details down to the 20 nm level. In this paper, we present results like contrast and sensitivity for PBW using, hydrogen silsesquioxane (HSQ) and XR-1541, both are non-C based resists. Unlike PMMA and SU-8 resist HSQ shows aging effects, requiring optimized processing parameters in PBW

  16. First negative ion beam measurement by the Short-Time Retractable Instrumented Kalorimeter Experiment (STRIKE)

    Science.gov (United States)

    Serianni, G.; De Muri, M.; Muraro, A.; Veltri, P.; Bonomo, F.; Chitarin, G.; Pasqualotto, R.; Pavei, M.; Rizzolo, A.; Valente, M.; Franzen, P.; Ruf, B.; Schiesko, L.

    2014-02-01

    The Source for Production of Ion of Deuterium Extracted from Rf plasma (SPIDER) test facility is under construction in Padova to optimise the operation of the beam source of ITER neutral beam injectors. The SPIDER beam will be characterised by the instrumented calorimeter STRIKE, whose main components are one-directional carbon-fibre-carbon-composite tiles. A small-scale version of the entire system has been employed in the BAvarian Test MAchine for Negative ions (BATMAN) testbed by arranging two prototype tiles in the vertical direction. The paper presents a description of the mini-STRIKE system and of the data analysis procedures, as well as some results concerning the BATMAN beam under varying operating conditions.

  17. First negative ion beam measurement by the Short-Time Retractable Instrumented Kalorimeter Experiment (STRIKE)

    International Nuclear Information System (INIS)

    Serianni, G.; De Muri, M.; Veltri, P.; Bonomo, F.; Chitarin, G.; Pasqualotto, R.; Pavei, M.; Rizzolo, A.; Valente, M.; Muraro, A.; Franzen, P.; Ruf, B.; Schiesko, L.

    2014-01-01

    The Source for Production of Ion of Deuterium Extracted from Rf plasma (SPIDER) test facility is under construction in Padova to optimise the operation of the beam source of ITER neutral beam injectors. The SPIDER beam will be characterised by the instrumented calorimeter STRIKE, whose main components are one-directional carbon-fibre-carbon-composite tiles. A small-scale version of the entire system has been employed in the BAvarian Test MAchine for Negative ions (BATMAN) testbed by arranging two prototype tiles in the vertical direction. The paper presents a description of the mini-STRIKE system and of the data analysis procedures, as well as some results concerning the BATMAN beam under varying operating conditions

  18. First negative ion beam measurement by the Short-Time Retractable Instrumented Kalorimeter Experiment (STRIKE)

    Energy Technology Data Exchange (ETDEWEB)

    Serianni, G., E-mail: gianluigi.serianni@igi.cnr.it; De Muri, M.; Veltri, P.; Bonomo, F.; Chitarin, G.; Pasqualotto, R.; Pavei, M.; Rizzolo, A.; Valente, M. [Consorzio RFX, Euratom-ENEA association, Corso Stati Uniti 4, 35127 Padova (Italy); Muraro, A. [Istituto di Fisica del Plasma, Associazione EURATOM-ENEA-CNR, Milano (Italy); Franzen, P.; Ruf, B.; Schiesko, L. [Max-Planck-Institut für Plasmaphysik, D-85748 Garching bei München (Germany)

    2014-02-15

    The Source for Production of Ion of Deuterium Extracted from Rf plasma (SPIDER) test facility is under construction in Padova to optimise the operation of the beam source of ITER neutral beam injectors. The SPIDER beam will be characterised by the instrumented calorimeter STRIKE, whose main components are one-directional carbon-fibre-carbon-composite tiles. A small-scale version of the entire system has been employed in the BAvarian Test MAchine for Negative ions (BATMAN) testbed by arranging two prototype tiles in the vertical direction. The paper presents a description of the mini-STRIKE system and of the data analysis procedures, as well as some results concerning the BATMAN beam under varying operating conditions.

  19. Polarizing a stored proton beam by spin flip?

    International Nuclear Information System (INIS)

    Oellers, D.; Barion, L.; Barsov, S.; Bechstedt, U.; Benati, P.; Bertelli, S.; Chiladze, D.; Ciullo, G.; Contalbrigo, M.; Dalpiaz, P.F.; Dietrich, J.; Dolfus, N.; Dymov, S.; Engels, R.; Erven, W.; Garishvili, A.; Gebel, R.; Goslawski, P.

    2009-01-01

    We discuss polarizing a proton beam in a storage ring, either by selective removal or by spin flip of the stored ions. Prompted by recent, conflicting calculations, we have carried out a measurement of the spin-flip cross section in low-energy electron-proton scattering. The experiment uses the cooling electron beam at COSY as an electron target. The measured cross sections are too small for making spin flip a viable tool in polarizing a stored beam. This invalidates a recent proposal to use co-moving polarized positrons to polarize a stored antiproton beam.

  20. High field superconducting beam transport in a BNL primary proton beam

    International Nuclear Information System (INIS)

    Allinger, J.; Brown, H.N.; Carroll, A.S.; Danby, G.; DeVito, B.; Glenn, J.W.; Jackson, J.; Keith, W.; Lowenstein, D.; Prodell, A.G.

    1979-01-01

    Construction of a slow external beam switchyard at the BNL AGS requires a rapid 20.4 0 bend in the upstream end of the beam line. Two curved superconducting window dipole magnets, operating at 6.0 T and about 80% of short sample magnetic field, will be utilized with two small superconducting sextupoles to provide the necessary deflection for a 28.5 GeV/c primary proton beam. Because the magnets will operate in a primary proton beam environment, they are designed to absorb large amounts of radiation heating from the beam without quenching. The field quality of the superconducting magnets is extremely good. Computer field calculations indicate a field error, ΔB/B 0 , equivalent to approx. = 1 x 10 -4 up to 75% of the 8.26 cm full aperture diameter in the magnet

  1. Dosimetric assessment of the PRESAGE dosimeter for a proton pencil beam

    International Nuclear Information System (INIS)

    Wuu, C-S; Qian, X; Xu, Y; Adamovics, J; Cascio, E; Lu, H-M

    2013-01-01

    The objective of this study is to assess the feasibility of using PRESAGE dosimeters for proton pencil beam dosimetry. Two different formulations of phantom materials were tested for their suitability in characterizing a single proton pencil beam. The dosimetric response of PRESAGE was found to be linear up to 4Gy. First-generation optical CT scanner, OCTOPUS TM was used to implement dose distributions for proton pencil beams since it provides most accurate readout. Percentage depth dose curves and beam profiles for two proton energy, 110 MeV, and 93 MeV, were used to evaluate the dosimetric performance of two PRESAGE phantom formulas. The findings from this study show that the dosimetric properties of the phantom materials match with basic physics of proton beams.

  2. ALPtraum. ALP production in proton beam dump experiments

    International Nuclear Information System (INIS)

    Doebrich, Babette; Jaeckel, Joerg

    2015-12-01

    With their high beam energy and intensity, existing and near-future proton beam dumps provide an excellent opportunity to search for new very weakly coupled particles in the MeV to GeV mass range. One particularly interesting example is a so-called axion-like particle (ALP), i.e. a pseudoscalar coupled to two photons. The challenge in proton beam dumps is to reliably calculate the production of the new particles from the interactions of two composite objects, the proton and the target atoms. In this work we argue that Primakoff production of ALPs proceeds in a momentum range where production rates and angular distributions can be determined to sufficient precision using simple electromagnetic form factors. Reanalysing past proton beam dump experiments for this production channel, we derive novel constraints on the parameter space for ALPs. We show that the NA62 experiment at CERN could probe unexplored parameter space by running in 'dump mode' for a few days and discuss opportunities for future experiments such as SHiP.

  3. Beam Phase Detection for Proton Therapy Accelerators

    CERN Document Server

    Aminov, Bachtior; Getta, Markus; Kolesov, Sergej; Pupeter, Nico; Stephani, Thomas; Timmer, J

    2005-01-01

    The industrial application of proton cyclotrons for medical applications has become one of the important contributions of accelerator physics during the last years. This paper describes an advanced vector demodulating technique used for non-destructive measurements of beam intensity and beam phase over 360°. A computer controlled I/Q-based phase detector with a very large dynamic range of 70 dB permits the monitoring of beam intensity, phase and eventually energy for wide range of beam currents down to -130 dBm. In order to avoid interference from the fundamental cyclotron frequency the phase detection is performed at the second harmonic frequency. A digital low pass filter with adjustable bandwidth and steepness is implemented to improve accuracy. With a sensitivity of the capacitive pickup in the beam line of 30 nV per nA of proton beam current at 250 MeV, accurate phase and intensity measurements can be performed with beam currents down to 3.3 nA.

  4. WE-D-BRB-02: Proton Treatment Planning and Beam Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Pankuch, M. [Northwestern Medicine Proton Center (United States)

    2016-06-15

    The goal of this session is to review the physics of proton therapy, treatment planning techniques, and the use of volumetric imaging in proton therapy. The course material covers the physics of proton interaction with matter and physical characteristics of clinical proton beams. It will provide information on proton delivery systems and beam delivery techniques for double scattering (DS), uniform scanning (US), and pencil beam scanning (PBS). The session covers the treatment planning strategies used in DS, US, and PBS for various anatomical sites, methods to address uncertainties in proton therapy and uncertainty mitigation to generate robust treatment plans. It introduces the audience to the current status of image guided proton therapy and clinical applications of CBCT for proton therapy. It outlines the importance of volumetric imaging in proton therapy. Learning Objectives: Gain knowledge in proton therapy physics, and treatment planning for proton therapy including intensity modulated proton therapy. The current state of volumetric image guidance equipment in proton therapy. Clinical applications of CBCT and its advantage over orthogonal imaging for proton therapy. B. Teo, B.K Teo had received travel funds from IBA in 2015.

  5. Faraday cup dosimetry in a proton therapy beam without collimation

    International Nuclear Information System (INIS)

    Grusell, Erik; Isacsson, Ulf; Montelius, Anders; Medin, Joakim

    1995-01-01

    A Faraday cup in a proton beam can give an accurate measurement of the number of protons collected by the cup. It is shown that the collection efficiency with a proper design can be close to unity. To be able to calibrate an ionization chamber from such a measurement, as is recommended in some dosimetry protocols, the energy spectrum of the proton beam must be accurately known. This is normally not the case when the lateral beam extension is defined by collimators. Therefore a method for relating an ionization chamber measurement in an uncollimated beam to the total number of protons in the beam has been developed and is described together with experimental results from calibrating an ionization chamber using this method in the therapeutic beam in Uppsala. This method is applicable to ionization chambers of any shape and the accuracy is estimated to be 1.6% (1 SD). (Author)

  6. Synchrotron accelerator technology for proton beam therapy with high accuracy

    International Nuclear Information System (INIS)

    Hiramoto, Kazuo

    2009-01-01

    Proton beam therapy was applied at the beginning to head and neck cancers, but it is now extended to prostate, lung and liver cancers. Thus the need for a pencil beam scanning method is increasing. With this method radiation dose concentration property of the proton beam will be further intensified. Hitachi group has supplied a pencil beam scanning therapy system as the first one for M. D. Anderson Hospital in United States, and it has been operational since May 2008. Hitachi group has been developing proton therapy system to correspond high-accuracy proton therapy to concentrate the dose in the diseased part which is located with various depths, and which sometimes has complicated shape. The author described here on the synchrotron accelerator technology that is an important element for constituting the proton therapy system. (K.Y.)

  7. Sparse-view proton computed tomography using modulated proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jiseoc; Kim, Changhwan; Cho, Seungryong, E-mail: scho@kaist.ac.kr [Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, Daejon 305-701 (Korea, Republic of); Min, Byungjun [Department of Radiation Oncology, Kangbuk Samsung Hospital, 110–746 (Korea, Republic of); Kwak, Jungwon [Department of Radiation Oncology, Asan Medical Center, 138–736 (Korea, Republic of); Park, Seyjoon; Lee, Se Byeong [Proton Therapy Center, National Cancer Center, 410–769 (Korea, Republic of); Park, Sungyong [Proton Therapy Center, McLaren Cancer Institute, Flint, Michigan 48532 (United States)

    2015-02-15

    Purpose: Proton imaging that uses a modulated proton beam and an intensity detector allows a relatively fast image acquisition compared to the imaging approach based on a trajectory tracking detector. In addition, it requires a relatively simple implementation in a conventional proton therapy equipment. The model of geometric straight ray assumed in conventional computed tomography (CT) image reconstruction is however challenged by multiple-Coulomb scattering and energy straggling in the proton imaging. Radiation dose to the patient is another important issue that has to be taken care of for practical applications. In this work, the authors have investigated iterative image reconstructions after a deconvolution of the sparsely view-sampled data to address these issues in proton CT. Methods: Proton projection images were acquired using the modulated proton beams and the EBT2 film as an intensity detector. Four electron-density cylinders representing normal soft tissues and bone were used as imaged object and scanned at 40 views that are equally separated over 360°. Digitized film images were converted to water-equivalent thickness by use of an empirically derived conversion curve. For improving the image quality, a deconvolution-based image deblurring with an empirically acquired point spread function was employed. They have implemented iterative image reconstruction algorithms such as adaptive steepest descent-projection onto convex sets (ASD-POCS), superiorization method–projection onto convex sets (SM-POCS), superiorization method–expectation maximization (SM-EM), and expectation maximization-total variation minimization (EM-TV). Performance of the four image reconstruction algorithms was analyzed and compared quantitatively via contrast-to-noise ratio (CNR) and root-mean-square-error (RMSE). Results: Objects of higher electron density have been reconstructed more accurately than those of lower density objects. The bone, for example, has been reconstructed

  8. Commissioning of output factors for uniform scanning proton beams

    International Nuclear Information System (INIS)

    Zheng Yuanshui; Ramirez, Eric; Mascia, Anthony; Ding Xiaoning; Okoth, Benny; Zeidan, Omar; Hsi Wen; Harris, Ben; Schreuder, Andries N.; Keole, Sameer

    2011-01-01

    Purpose: Current commercial treatment planning systems are not able to accurately predict output factors and calculate monitor units for proton fields. Patient-specific field output factors are thus determined by either measurements or empirical modeling based on commissioning data. The objective of this study is to commission output factors for uniform scanning beams utilized at the ProCure proton therapy centers. Methods: Using water phantoms and a plane parallel ionization chamber, the authors first measured output factors with a fixed 10 cm diameter aperture as a function of proton range and modulation width for clinically available proton beams with ranges between 4 and 31.5 cm and modulation widths between 2 and 15 cm. The authors then measured the output factor as a function of collimated field size at various calibration depths for proton beams of various ranges and modulation widths. The authors further examined the dependence of the output factor on the scanning area (i.e., uncollimated proton field), snout position, and phantom material. An empirical model was developed to calculate the output factor for patient-specific fields and the model-predicted output factors were compared to measurements. Results: The output factor increased with proton range and field size, and decreased with modulation width. The scanning area and snout position have a small but non-negligible effect on the output factors. The predicted output factors based on the empirical modeling agreed within 2% of measurements for all prostate treatment fields and within 3% for 98.5% of all treatment fields. Conclusions: Comprehensive measurements at a large subset of available beam conditions are needed to commission output factors for proton therapy beams. The empirical modeling agrees well with the measured output factor data. This investigation indicates that it is possible to accurately predict output factors and thus eliminate or reduce time-consuming patient-specific output

  9. Characterization of a proton beam driven by a high-intensity laser

    International Nuclear Information System (INIS)

    Sagisaka, Akito; Daido, Hiroyuki; Ogura, Koichi; Orimo, Satoshi; Hayashi, Yukio; Mori, Michiaki; Nishiuchi, Mamiko; Yogo, Akifumi; Kado, Masataka; Fukumi, Atsushi; Li, Zhong; Pirozhkov, Alexander S.; Nakamura, Shu

    2007-01-01

    High-energy protons are observed with a 3 μm thick tantalum target irradiated with a high intensity laser. The maximum proton energy is ∼900 keV. The half angle of the generated proton beam (>500 keV) is about 10deg. Characterization of the proton beam will significantly contribute to the proton applications. (author)

  10. AA, entrance of proton beam to antiproton production target

    CERN Multimedia

    CERN PhotoLab

    1980-01-01

    Please look up 8010295 first. The intense proton beam from the 26 GeV PS arrives from the right, through the vacuum chamber. The big flange contains a thin window, after which the proton beam continues through free air. A beam transformer, affixed to the shielding block, measures its intensity, before it enters the hole in the concrete to hit the target behind it.

  11. Evaluation of the Induced Activity in Air by the External Proton Beam in the Target Room of the Proton Accelerator Facility of Proton Engineering Frontier Project

    International Nuclear Information System (INIS)

    Lee, Cheol Woo; Lee, Young Ouk; Cho, Young Sik; Ahn, So Hyun

    2007-01-01

    One of the radiological concerns is the worker's exposure level and the concentration of the radionuclides in the air after shutdown, for the safety analysis on the proton accelerator facility. Although, the primary radiation source is the protons accelerated up to design value, all of the radio-nuclide is produced from the secondary neutron and photon induced reaction in air. Because, the protons don't penetrate the acceleration equipment like the DTL tank wall or BTL wall, secondary neutrons or photons are only in the air in the accelerator tunnel building because of the short range of the proton in the materials. But, for the case of the target rooms, external proton beams are occasionally used in the various experiments. When these external proton beams travel through air from the end of the beam transport line to the target, they interact directly with air and produce activation products from the proton induced reaction. The external proton beam will be used in the target rooms in the accelerator facility of the Proton Accelerator Frontier Project (PEFP). In this study, interaction characteristics of the external proton beam with air and induced activity in air from the direct interaction of the proton beam were evaluated

  12. Proton external beam in the TANDAR Accelerator

    International Nuclear Information System (INIS)

    Rey, R.; Schuff, J.A.; Perez de la Hoz, A.; Debray, M.E.; Hojman, D.; Kreiner, A.J.; Kesque, J.M.; Saint-Martin, G.; Oppezzo, O.; Bernaola, O.A.; Molinari, B.L.; Duran, H.A.; Policastro, L.; Palmieri, M.; Ibanez, J.; Stoliar, P.; Mazal, A.; Caraballo, M.E.; Burlon, A.; Cardona, M.A.; Vazquez, M.E.; Salfity, M.F.; Ozafran, M.J.; Naab, F.; Levinton, G.; Davidson, M.; Buhler, M.

    1998-01-01

    An external proton beam has been obtained in the TANDAR accelerator with radiological and biomedical purposes. The protons have excellent physical properties for their use in radiotherapy allowing a very good accuracy in the dose spatial distribution inside the tissue so in the side direction as in depth owing to the presence of Bragg curve. The advantage of the accuracy in the dose localization with proton therapy is good documented (M. Wagner, Med. Phys. 9, 749 (1982); M. Goitein and F. Chen, Med. Phys. 10, 831 (1983); M.R. Raju, Rad. Res. 145, 391 (1996)). It was obtained external proton beams with energies between 15-25 MeV, currents between 2-10 p A and a uniform transversal sections of 40 mm 2 approximately. It was realized dosimetric evaluations with CR39 and Makrofol foliation. The irradiations over biological material contained experiences In vivo with laboratory animals, cellular and bacterial crops. It was fixed the optimal conditions of position and immobilization of the Wistar rats breeding for the In vivo studies. It was chosen dilutions and sowing techniques adequate for the exposition at the cellular and bacterial crops beam. (Author)

  13. Distribution uniformity of laser-accelerated proton beams

    Science.gov (United States)

    Zhu, Jun-Gao; Zhu, Kun; Tao, Li; Xu, Xiao-Han; Lin, Chen; Ma, Wen-Jun; Lu, Hai-Yang; Zhao, Yan-Ying; Lu, Yuan-Rong; Chen, Jia-Er; Yan, Xue-Qing

    2017-09-01

    Compared with conventional accelerators, laser plasma accelerators can generate high energy ions at a greatly reduced scale, due to their TV/m acceleration gradient. A compact laser plasma accelerator (CLAPA) has been built at the Institute of Heavy Ion Physics at Peking University. It will be used for applied research like biological irradiation, astrophysics simulations, etc. A beamline system with multiple quadrupoles and an analyzing magnet for laser-accelerated ions is proposed here. Since laser-accelerated ion beams have broad energy spectra and large angular divergence, the parameters (beam waist position in the Y direction, beam line layout, drift distance, magnet angles etc.) of the beamline system are carefully designed and optimised to obtain a radially symmetric proton distribution at the irradiation platform. Requirements of energy selection and differences in focusing or defocusing in application systems greatly influence the evolution of proton distributions. With optimal parameters, radially symmetric proton distributions can be achieved and protons with different energy spread within ±5% have similar transverse areas at the experiment target. Supported by National Natural Science Foundation of China (11575011, 61631001) and National Grand Instrument Project (2012YQ030142)

  14. Induction of cancer cell death by proton beam in tumor hypoxic region

    International Nuclear Information System (INIS)

    Lee, Y. M.; Heo, T. R.; Lee, K. B.; Jang, K. H.; Kim, H. N.; Lee, S. H.; Jeong, M. H.

    2008-04-01

    Proton beam has been applied to treat various tumor patients in clinical studies. However, it is still undefined whether proton radiation can inhibit the blood vessel formation and induce the cell death in vascular endothelial cells in growing organs. The aim of this study are first, to develop an optimal animal model for the observation of blood vessel development with low dose of proton beam and second, to investigate the effect of low dose proton beam on the inhibition of blood vessel formation induced by hypoxic conditions. In this study, flk1-GFP transgenic zebrafish embryos were used to directly visualize and determine the inhibition of blood vessels by low dose (1, 2, 5 Gy) of proton beam with spread out Bragg peak (SOBP). And we observed cell death by acridine orange staining at 96 hours post fertilization (hpf) stage of embryos after proton irradiation. We also compared the effects of proton beam with those of gamma-ray. An antioxidant, N-acetyl cystein (NAC) was used to investigate whether reactive oxygen species (ROS) were involved in the cell deaths induced by proton irradiation. Irradiated flk-1-GFP transgenic embryos with proton beam irradiation (35 MeV, spread out Bragg peak, SOBP) demonstrated a marked inhibition of embryonic growth and an altered fluorescent blood vessel development in the trunk region. When the cells with DNA damage in the irradiated zebrafish were stained with acridine orange, green fluorescent cell death spots were increased in trunk regions compared to non-irradiated control embryos. Proton beam also significantly increased the cell death rate in human umbilical vein endothelial cells (HUVEC), but pretreatment of N-acetyl cystein (NAC), an antioxidant, recovered the proton-induced cell death rate (p<0.01). Moreover, pretreatment of NAC abrogated the effect of proton beam on the inhibition of trunk vessel development and malformation of trunk truncation. From this study, we found that proton radiation therapy can inhibit the

  15. Dosimetry of clinical neutron and proton beams: An overview of recommendations

    International Nuclear Information System (INIS)

    Vynckier, S.

    2004-01-01

    Neutron therapy beams are obtained by accelerating protons or deuterons on Beryllium. These neutron therapy beams present comparable dosimetric characteristics as those for photon beams obtained with linear accelerators; for instance, the penetration of a p(65) + Be neutron beam is comparable with the penetration of an 8 MV photon beam. In order to be competitive with conventional photon beam therapy, the dosimetric characteristics of the neutron beam should therefore not deviate too much from the photon beam characteristics. This paper presents a brief summary of the neutron beams used in radiotherapy. The dosimetry of the clinical neutron beams is described. Finally, recent and future developments in the field of physics for neutron therapy is mentioned. In the last two decades, a considerable number of centres have established radiotherapy treatment facilities using proton beams with energies between 50 and 250 MeV. Clinical applications require a relatively uniform dose to be delivered to the volume to be treated, and for this purpose the proton beam has to be spread out, both laterally and in depth. The technique is called 'beam modulation' and creates a region of high dose uniformity referred to as the 'spread-out Bragg peak'. Meanwhile, reference dosimetry in these beams had to catch up with photon and electron beams for which a much longer tradition of dosimetry exists. Proton beam dosimetry can be performed using different types of dosemeters, such as calorimeters, Faraday cups, track detectors and ionisation chambers. National standard dosimetry laboratories will, however, not provide a standard for the dosimetry of proton beams. To achieve uniformity on an international level, the use of an ionisation chamber should be considered. This paper reviews and summarises the basic principles and recommendations for the absorbed dose determination in a proton beam, utilising ionisation chambers calibrated in terms of absorbed dose to water. These recommendations

  16. Linac4 45 keV Proton Beam Measurements

    CERN Document Server

    Bellodi, G; Hein, L M; Lallement, J-B; Lombardi, A M; Midttun, O; Scrivens, R; Posocco, P A

    2013-01-01

    Linac4 is a 160 MeV normal-conducting H- linear accelerator, which will replace the 50 MeV proton Linac2 as injector for the CERN proton complex. Commissioning of the low energy part - comprising the H - source, a 45 keV Low Energy Beam Transport line (LEBT), a 3 MeV Radiofrequency Quadrupole (RFQ) and a Medium Energy Beam Transport (MEBT) - will start in fall 2012 on a dedicated test stand installation. In preparation to this, preliminary measurements were taken using a 45 keV proton source and a temporary LEBT setup, with the aim of characterising the output beam by comparison with the predictions of simulations. At the same time this allowed a first verification of the functionalities of diagnostics instrumentation and acquisition software tools. Measurements of beam profile, emittance and intensity were taken in three different setups: right after the source, after the first and after the second LEBT solenoids respectively. Particle distributions were reconstructed from emittance scan...

  17. Therapeutic study of proton beam in vascular disease animal models

    International Nuclear Information System (INIS)

    Lee, Y. M.; Jang, K. H.; Kim, M. J.; Choi, J. H.

    2010-04-01

    We previously reported that proton beam inhibited angiogenic vessels in zebrafish and that proton induced cancer cell apoptosis via p53 induction as well as caspase-3 activity. In this study, we performed to identity the effect of candidate chemicals on the angiogenic inhibition in vitro and in vivo (zebrafish Flk1:EGFP transgenic fish). And we treated small cell lung adenocarcinoma cell line, A549 cells with proton beam in combination with angiogenic inhibitors we found in this study. By the MTT assay, we performed cell viability assay with cancer cells and we investigated that HIF-1α induction by proton beam by the western blot analysis. We found novel anti-angiogenic chemicals from traditional herb. That is decursin, and glyceollins from the Angelica gigas, and soy bean. Decrusin and glyceollins inhibited VEGF- or bFGF-induced endothelial cell proliferation, migration and zebrafish microvessel development. Moreover, glyceollins inhibited hypoxia-induced HIF-1α in a dose dependent manner. However, proton beam itself did not induce HIF-1α whereas it increased HIF-1α stability under hypoxia. Even proton beam induced cell death of A549 small cell lung carcinoma cells but the combination of decrusin or glyceollins did not increase the cancer cell death

  18. Therapeutic study of proton beam in vascular disease animal models

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Y. M.; Jang, K. H.; Kim, M. J.; Choi, J. H. [Kyungpook National University, Daegu (Korea, Republic of)

    2010-04-15

    We previously reported that proton beam inhibited angiogenic vessels in zebrafish and that proton induced cancer cell apoptosis via p53 induction as well as caspase-3 activity. In this study, we performed to identity the effect of candidate chemicals on the angiogenic inhibition in vitro and in vivo (zebrafish Flk1:EGFP transgenic fish). And we treated small cell lung adenocarcinoma cell line, A549 cells with proton beam in combination with angiogenic inhibitors we found in this study. By the MTT assay, we performed cell viability assay with cancer cells and we investigated that HIF-1{alpha} induction by proton beam by the western blot analysis. We found novel anti-angiogenic chemicals from traditional herb. That is decursin, and glyceollins from the Angelica gigas, and soy bean. Decrusin and glyceollins inhibited VEGF- or bFGF-induced endothelial cell proliferation, migration and zebrafish microvessel development. Moreover, glyceollins inhibited hypoxia-induced HIF-1{alpha} in a dose dependent manner. However, proton beam itself did not induce HIF-1{alpha} whereas it increased HIF-1{alpha} stability under hypoxia. Even proton beam induced cell death of A549 small cell lung carcinoma cells but the combination of decrusin or glyceollins did not increase the cancer cell death

  19. Influence of transverse diffusion within the proton beam fast-ignitor scenario

    International Nuclear Information System (INIS)

    Barriga-Carrasco, Manuel D.; Maynard, Gilles; Kurilenkov, Yuri K.

    2004-01-01

    Fast ignition of an inertial confinement fusion target by an energetic proton beam is here re-examined. We put special emphasis on the role of the transverse dispersion of the beam induced during its travel between the proton source and the compressed deuterium-tritium (DT) fuel. The theoretical model and the computer code used in our calculations are presented. Different beam initial energy distributions are analyzed. We found that the beam exhibits small collective effects while multiple scattering collisions provide a substantial transverse dispersion of the beam. Therefore, the nuclear dispersion imposes severe restrictions on the schemes for fast ignitor even considering an ideal monoenergetic and noncorrelated proton beam

  20. An analysis of beam parameters on proton-acoustic waves through an analytic approach.

    Science.gov (United States)

    Kipergil, Esra Aytac; Erkol, Hakan; Kaya, Serhat; Gulsen, Gultekin; Unlu, Mehmet Burcin

    2017-06-21

    It has been reported that acoustic waves are generated when a high-energy pulsed proton beam is deposited in a small volume within tissue. One possible application of proton-induced acoustics is to get real-time feedback for intra-treatment adjustments by monitoring such acoustic waves. A high spatial resolution in ultrasound imaging may reduce proton range uncertainty. Thus, it is crucial to understand the dependence of the acoustic waves on the proton beam characteristics. In this manuscript, firstly, an analytic solution for the proton-induced acoustic wave is presented to reveal the dependence of the signal on the beam parameters; then it is combined with an analytic approximation of the Bragg curve. The influence of the beam energy, pulse duration and beam diameter variation on the acoustic waveform are investigated. Further analysis is performed regarding the Fourier decomposition of the proton-acoustic signals. Our results show that the smaller spill time of the proton beam upsurges the amplitude of the acoustic wave for a constant number of protons, which is hence beneficial for dose monitoring. The increase in the energy of each individual proton in the beam leads to the spatial broadening of the Bragg curve, which also yields acoustic waves of greater amplitude. The pulse duration and the beam width of the proton beam do not affect the central frequency of the acoustic wave, but they change the amplitude of the spectral components.

  1. Slaw extracted proton beam formation and monitoring for the ''QUARTZ'' setup

    International Nuclear Information System (INIS)

    Bushnin, Yu.B.; Gres', V.N.; Davydenko, Yu.P.

    1982-01-01

    The version of optical mode of the beam channel providing with simultaneous operating the experimental setups FODS and ''QUARTZ'' at consecutive usage of the slow extracted proton beam is reported. The ''QUARTZ'' setup beam diagnostics system comprises two subsystems: for measuring beam profile beam timing structure and beam intensity and operates in the beam extraction duration from 20 ns to few seconds at beam intensity from 10 10 to 5x10 12 protons/pulse. The ''QUARTZ'' setup represents a focusing crystal-diffraction spectrometer with 5-meter focal distance and Ge(Li) special construction detector. High efficiency target is applied in the setup. The ''QUARTZ'' setup is designed for studying exotic atoms produced by negative charged heavy particles (π, K, μ, P tilde) and atomic nuclei. Precise energy measurement of X ray transitions in such atoms is performed. For measuring beam geometric parameters 32-channel secondary emission chambers are used. As detector of beam intensity and timing structure of slow extracted beam the secondary emission chamber is employed. The principle circuit of current integrator is given. As data transmission line a 50-pair telephone cable is used. Information conversion into digital form and its subsequent processing is performed in the CAMAC system and the SM-3 computer. The proton beam full intensity measuring system provides with accuracy not worse than +-4.5% in the 10 10 -10 12 proton/sec range. The implemented optical mode of the beam channel and proton beam monitoring system permitted to begin fulfillment of the experimental program on the ''QUARTZ'' setup

  2. Effect of Proton Beam on Cancer Progressive and Metastatic Enzymes

    International Nuclear Information System (INIS)

    Sohn, Y. H.; Nam, K. S.; Oh, Y. H.; Kim, M. K.; Kim, M. Y.; Jang, J. S.

    2008-04-01

    The purpose of this study was to investigate the effect of proton beam on enzymes for promotion/progression of carcinogenesis and metastasis of malignant tumor cells to clarify proton beam-specific biological effects. The changes of cancer chemopreventive enzymes in human colorectal adenocarcinoma HT-29 cells irradiated with proton beams were tested by measuring the activities of quinine reductase (QR), glutathione S-transferase (GST), and ornithine decarboxylase (ODC), glutathione (GSH) levels, and expression of cyclooxygenase-2 (COX-2). We also examined the effect of proton beam on the ODC activity and expression of COX-2 in human breast cancer cell. We then assessed the metastatic capabilities of HT-29 and MDA-MB-231 cells irradiated with proton beam by measuring the invasiveness of cells through Matrigel-coated membrane and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP activity in MDA-MB-231 and HT-29 cells. QR activity of irradiated HT-29 cells was slightly increased. Proton irradiation at dose of 32 Gy in HT-29 cells increased GST activity by 1.23-fold. In addition GSH levels in HT-29 cells was significantly increased 1.23- (p<0.05), 1.32- (p<0.01) and 1.34-fold (p<0.01) with the proton irradiation at doses of 8, 16 and 32 Gy, respectively. These results suggest that colon cancer chemopreventive activity was increased with the proton irradiation by increasing QR and GST activities and GSH levels and inhibiting ODC activity. Proton ion irradiation decreased the invasiveness of TPA-treated HT-29 cells and MDA-MB-231 cells through Matrigel-coated membrane. Proton ion irradiation pretreatment decreased TPA-induced MMP activity in MDA-MB-231 and HT-29 cells. Further studies are necessary to investigate if these findings could be translated to in vivo situations

  3. Biological effects and application of proton beam (H+) implantation on melon seeds

    International Nuclear Information System (INIS)

    Sun Xun; Ren Ruixing; Meng Hui; Shi Jinguo; Tang Zhangxiong; Tao Xianping

    2006-01-01

    Various doses and energy of the proton beam (H + ) were used to treat dry seeds of melon (Cucumis melo L.). Results show that, the proton beam irradiation can induced structural variations of chromosomes and abnormal behaviors during mitosis and meiosis. The percentage of cells with chromosomal aberration increased with the increment of energy and dose of the proton. The micronuclei, chromosomal bridge and chromosomal fragments were included in chromosomal aberration. The proton beam was effective in inducing mutants of early maturity. A early maturity line T 63-1-17-8-1-3 was selected from the progenies of the seeds treated with the proton beam. (authors)

  4. Modification of semiconductors with proton beams. A review

    International Nuclear Information System (INIS)

    Kozlovskii, V.V.; Lomasov, V.N.; Kozlov, V.A.

    2000-01-01

    Analysis is given of the progress in the modification of semiconductors by proton beams in fields such as proton-enhanced diffusion, ion-beam mixing, and formation of porous layers. This method of modification (doping) is shown to have high potential in monitoring the properties of semiconductor materials and designing devices of micro and nano electronics as compared to the conventional doping techniques such as thermal diffusion, epitaxy, and ion implantation

  5. The development of MEMS device packaging technology using proton beam

    International Nuclear Information System (INIS)

    Hyeon, J. W.; Kong, Y. J.; Kim, E. H.; Kim, H. S.; No, S. J.

    2006-05-01

    Wafer-bonding techniques are key issues for the commercialization of MEMS(MicroElectroMechanical Systems) devices. The anodic bonding method and the wafer direct-bonding method are well-known major techniques for wafer bonding. Due to the anodic bonding method includes high voltage processes above 1.5 kV, the MEMS devices can be damaged during the bonding process or malfunctioned while long-term operation. On the other hand, since the wafer direct-bonding method includes a high temperature processes above 1000 .deg. C, temperature-sensitive materials and integrated circuits will be damaged or degraded during the bonding processes. Therefore, high-temperature bonding processes are not applicable for fabricating or packaging devices where temperature-sensitive materials exist. During the past few years, much effort has been undertaken to find a reliable bonding process that can be conducted at a low temperature. Unfortunately, these new bonding processes depend highly on the bonding material, surface treatment and surface flatness. In this research, a new packaging method using proton beam irradiation is proposed. While the energy loss caused in an irradiated material by X-rays or electron beams decreases with the surface distance, the energy loss caused by proton beams has a maximum value at the Bragg peak. Thus, the localized energy produced at the Bragg peak of the proton beams can be used to bond pyrex glass on a silicon wafer, so the MEMS damage is expected to be minimized. The localized heating caused by as well as the penetration depth, or the proton beam has been investigated. The energy absorbed in a stack of pyrex glass/silicon wafers due to proton-beam irradiation was numerically calculated for various proton energies by using the SRIM program. The energy loss was shown to be sufficiently localized at the interface between the pyrex glass and the silicon wafer. Proton beam irradiation was performed in the common environment of room temperature and

  6. The polarized proton and deuteron beam at the Bonn isochronous cyclotron

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, K G; Enders, R; Hammon, W; Krause, K D; Lesemann, D; Scholzen, A [Bonn Univ. (F.R. Germany). Inst. fuer Angewandte Physik; Euler, K; Schueller, B [Bonn Univ. (F.R. Germany). Inst. fuer Strahlen- und Kernphysik

    1976-02-15

    The present state of the polarized proton and deuteron source at the Bonn cyclotron is described. The source, which is of the atomic beam type, gives typical ion beam intensities of 2 ..mu..A for protons and 3 ..mu..A for deuterons. The overall transmission from the source to the first stopper after extraction from the cyclotron is 3%. Target currents with an energy resolution E/..delta..E=500 are 20 nA for deuterons and 10 nA for protons. For the proton beam, a polarization P=-0.71 was measured. For the deuteron beam, a pure vector polarization Psub(z)=-0.47 or various mixtures of vector and tensor polarization are obtained.

  7. Laser-driven proton beams applied to radiobiological experiments

    International Nuclear Information System (INIS)

    Yogo, Akifumi

    2012-01-01

    The proton accelerators based on the high intensity laser system generate shorter and higher pulse beams compared to the conventional particle accelerators used for the cancer therapy. To demonstrate the radiobiological effects of the new proton beams, the program to develop a biological irradiation instrument for the DNA double-strand break was started in the fiscal year 2008. A prototype instrument was made by making use of the J-KAREN (JAEA Kansai Advanced Relativistic Engineering) laser beam. Polyimide thin film targets were used to irradiate A-549 cells. The DNA double-strand break was tested by the fluorescence spectrometry. In the second year the quantitative yield of the DNA double-strand break and its proton dose dependence were measured. The results indicated that they were comparative to the cases of the conventional particle accelerators. In the fiscal year of 2010 the design of the magnetic field for the energy selection has been changed. The new irradiation instrument, the main part of which is only about 40 cm in length as illustrated in the figure, has been constructed and tested. The experiment has been carried out using the human cancer cells (HSG) and the relative biological effectiveness (RBE) has been quantitatively evaluated by the colony assay for varied distribution of the proton beam energy. The survival fractions plotted against the dose were in good agreement with the case of 3 He beam. RBE was found not to be changed up to 1x10 7 Gy/s. Stability of the energy peak, half width and the proton density has been confirmed for this very compact instrument. (S. Funahashi)

  8. Beam diagnostics for Laser-induced proton generation at KAERI

    International Nuclear Information System (INIS)

    Kim, Dong Heun; Park, Seong Hee; Jeong, Young Uk; Lee, Ki Tae; Chan, Young Ho; Lee, Byung Cheol; Yoo, Byeong Duk

    2005-01-01

    With an advent of femto-second lasers, a laseraccelerated ion generation has been world-widely studied for medical and nuclear applications. It is known that protons with the energy from several tens MeV to a few hundreds MeV require for a cancer therapy and nuclear reaction. Even though, up to present, the maximum energy of laser-accelerated proton is about 60 MeV, it is expected that the energy of protons generated can be obtained at least up to 150 MeV. According to theoretical and experimental works, it turns out the energy distribution and the flux of ions strongly depends on the intensity of a fs laser at a target. However, physics on laser-plasma interaction is still not clear. The precise measurements of parameters of a fs laser and ions are important to figure out the physics and develop the theoretical interpretation. Typically, beam diagnostic system includes measurements and/or monitoring of the temporal and spatial profiles of lasers at the target as well as the energy spectrum and density profile of protons, which are critical for the analysis of mechanism and the characterization of protons generated. We fabricated and installed the target chamber for laser-accelerated proton generation and are now integrating beam diagnostic system. For laser diagnostics, beam monitoring and alignment system has been installed. For a charged particle, CR-39 detectors, Thomson parabola spectrometer, and Si charged particle detectors are installed for density profile and energy spectrum. In this paper, we discuss the laser beam monitoring and alignment system. We also estimates expected spectrum of protons from Thomson parabola spectrometer, depending on the parameters of protons

  9. Fabrication of Multi-Harmonic Buncher for Pulsed Proton Beam Generation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, H. S.; Kwon, H. J.; Cho, Y. S. [Korea Multipurpose Accelerator Complex, Gyeongju (Korea, Republic of)

    2015-05-15

    Fast neutrons with a broad spectrum can be generated by irradiating the proton beams on target materials. To measure the neutron energy by time of flight (TOF) method, the short pulse width of the proton beam is preferred because the neutron energy uncertainty is proportional to the pulse width. In addition, the pulse repetition rate should be low enough to extend the lower limit of the available neutron energy. Pulsed proton beam generation system is designed based on an electrostatic deflector and slit system as shown in Fig. 1. In a simple deflector with slit system, most of the proton beam is blocked by slit, especially when the beam pulse width is short. The ideal field pattern inside the buncher cavity is saw-tooth wave. To make the field pattern similar to the saw-tooth waveform, we adopted a multi-harmonic buncher (MHB). The design for the multi-harmonic buncher including 3D electromagnetic calculation has been performed. Based on the design, a multi-harmonic buncher cavity was fabricated. It consists of two resonators, two drift tubes and a vacuum chamber. The resonator is a quarter-wave coaxial resonator type. The drift tube is connected to the resonator by using a coaxial vacuum feedthrough. Design summary and detailed fabrication method of the multi-harmonic buncher is presented in this paper. A multi-harmonic buncher for a proton beam chopper system to generate a short pulse neutron beam was designed, fabricated and assembled.

  10. Proton beam radiotherapy of iris melanoma

    International Nuclear Information System (INIS)

    Damato, Bertil; Kacperek, Andrzej; Chopra, Mona; Sheen, Martin A.; Campbell, Ian R.; Errington, R. Douglas

    2005-01-01

    Purpose: To report on outcomes after proton beam radiotherapy of iris melanoma. Methods and Materials: Between 1993 and 2004, 88 patients with iris melanoma received proton beam radiotherapy, with 53.1 Gy in 4 fractions. Results: The patients had a mean age of 52 years and a median follow-up of 2.7 years. The tumors had a median diameter of 4.3 mm, involving more than 2 clock hours of iris in 32% of patients and more than 2 hours of angle in 27%. The ciliary body was involved in 20%. Cataract was present in 13 patients before treatment and subsequently developed in another 18. Cataract had a 4-year rate of 63% and by Cox analysis was related to age (p = 0.05), initial visual loss (p < 0.0001), iris involvement (p < 0.0001), and tumor thickness (p < 0.0001). Glaucoma was present before treatment in 13 patients and developed after treatment in another 3. Three eyes were enucleated, all because of recurrence, which had an actuarial 4-year rate of 3.3% (95% CI 0-8.0%). Conclusions: Proton beam radiotherapy of iris melanoma is well tolerated, the main problems being radiation-cataract, which was treatable, and preexisting glaucoma, which in several patients was difficult to control

  11. YAP(Ce) crystal characterization with proton beam up to 60 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Randazzo, N. [Istituto Nazionale di Fisica Nucleare, Sezione di Catania (I), Via S. Sofia, 64-I-95123 Catania (Italy)], E-mail: nunzio.randazzo@ct.infn.it; Sipala, V.; Aiello, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Catania (I), Via S. Sofia, 64-I-95123 Catania (Italy); Lo Presti, D. [Istituto Nazionale di Fisica Nucleare, Sezione di Catania (I), Via S. Sofia, 64-I-95123 Catania (Italy); Dipartimento di Fisica e Astronomia, Universita di Catania, Catania (Italy); Cirrone, G.A.P.; Cuttone, G.; Di Rosa, F. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud (Italy)

    2008-02-21

    A YAP(Ce) crystal was characterized with a proton beam up to 60 MeV. Tests were performed to investigate the possibility of using this detector as a proton calorimeter. The size of the crystal was chosen so that the proton energy is totally lost inside the medium. The authors propose to use the YAP(Ce) crystal in medical applications for proton therapy. In particular, in proton computed tomography (pCT) project it is necessary as a calorimeter in order to measure the proton residual energy after the phantom. Energy resolution, linearity, and light yield were measured in the Laboratori Nazionali del Sud with the CATANA proton beam [ (http://www.lns.infn.it/CATANA/CATANA)] and the results are shown in this paper. The crystal shows a good resolution (3% at 60 MeV proton beam) and it shows good linearity for different proton beam energies (1% at 30-60 MeV energy range). The crystal performances confirm that the YAP(Ce) crystal represents a good solution for these kinds of application.

  12. YAP(Ce) crystal characterization with proton beam up to 60 MeV

    International Nuclear Information System (INIS)

    Randazzo, N.; Sipala, V.; Aiello, S.; Lo Presti, D.; Cirrone, G.A.P.; Cuttone, G.; Di Rosa, F.

    2008-01-01

    A YAP(Ce) crystal was characterized with a proton beam up to 60 MeV. Tests were performed to investigate the possibility of using this detector as a proton calorimeter. The size of the crystal was chosen so that the proton energy is totally lost inside the medium. The authors propose to use the YAP(Ce) crystal in medical applications for proton therapy. In particular, in proton computed tomography (pCT) project it is necessary as a calorimeter in order to measure the proton residual energy after the phantom. Energy resolution, linearity, and light yield were measured in the Laboratori Nazionali del Sud with the CATANA proton beam [ (http://www.lns.infn.it/CATANA/CATANA)] and the results are shown in this paper. The crystal shows a good resolution (3% at 60 MeV proton beam) and it shows good linearity for different proton beam energies (1% at 30-60 MeV energy range). The crystal performances confirm that the YAP(Ce) crystal represents a good solution for these kinds of application

  13. YAP(Ce) crystal characterization with proton beam up to 60 MeV

    Science.gov (United States)

    Randazzo, N.; Sipala, V.; Aiello, S.; Lo Presti, D.; Cirrone, G. A. P.; Cuttone, G.; Di Rosa, F.

    2008-02-01

    A YAP(Ce) crystal was characterized with a proton beam up to 60 MeV. Tests were performed to investigate the possibility of using this detector as a proton calorimeter. The size of the crystal was chosen so that the proton energy is totally lost inside the medium. The authors propose to use the YAP(Ce) crystal in medical applications for proton therapy. In particular, in proton computed tomography (pCT) project it is necessary as a calorimeter in order to measure the proton residual energy after the phantom. Energy resolution, linearity, and light yield were measured in the Laboratori Nazionali del Sud with the CATANA proton beam [ http://www.lns.infn.it/CATANA/CATANA] and the results are shown in this paper. The crystal shows a good resolution (3% at 60 MeV proton beam) and it shows good linearity for different proton beam energies (1% at 30-60 MeV energy range). The crystal performances confirm that the YAP(Ce) crystal represents a good solution for these kinds of application.

  14. Measuring proton beam thermal noises on the NAP-M storage ring

    International Nuclear Information System (INIS)

    Dement'ev, E.N.; Dikanskij, N.S.; Medvedko, A.S.; Parkhomchuk, V.V.; Pestrikov, D.V.

    1980-01-01

    The data on experimental investigation of thermal noises of an asimuthally homogeneous proton beam on the NAP-M storage ring are given. The noise spectra are measured at the 5th and 8th harmonics of the ciculation frequency using pick-up electrodes. The dependencies of the noise power on the proton current for noncooled and cooled beams are presented. It is shown that as a result of electron cooling the noise power decreases by two orders and in the 0.5-10 μA current range the noise power of the cooled beam does not depend on the proton current. The noise power of the noncooled beam linearly increases with the proton current. It is also shown that with the modulation growth the noise power increases. The conclusions are made that while analyzing noises of the continuous beam in the storage ring the changes of the noise spectra due to particle interaction in the beam should be taken into account

  15. How It's Made - Polarized Proton Beam (444th Brookhaven Lecture)

    International Nuclear Information System (INIS)

    Zelenski, Anatoli

    2008-01-01

    Experiments with polarized beams at RHIC will provide fundamental tests of QCD, and the electro-weak interaction reveal the spin structure of the proton. Polarization asymmetries and parity violation are the strong signatures for identification of the fundamental processes, which are otherwise inaccessible. Such experiments require the maximum available luminosity and therefore polarization must be obtained as an extra beam quality without sacrificing intensity. There are proposals to polarize the high-energy proton beam in the storage rings by the Stern-Gerlach effect or spin-filter techniques. But so far, the only practically available option is acceleration of the polarized beam produced in the source and taking care of polarization survival during acceleration and storage. Two major innovations -- the 'Siberian Snake' technique for polarization preservation during acceleration and high current polarized proton sources make spin physics with the high-energy polarized beams feasible. The RHIC is the first high-energy collider, where the 'Siberian Snake' technique allowed of polarized proton beam acceleration up-to 250 GeV energy. The RHIC unique Optically Pumped Polarized Ion Source produces sufficient polarized beam intensity for complete saturation of the RHIC acceptance. This polarization technique is based on spin-transfer collisions between a proton or atomic hydrogen beam of a few keV beam energy and optically pumped alkali metal vapors. From the first proposal and feasibility studies to the operational source this development can be considered as example of successful unification of individual scientists ingenuity, international collaboration and modern technology application for creation of a new polarization technique, which allowed of two-to-three order of magnitude polarized beam intensity increase sufficient for loading the RHIC to its full capacity for polarization studies.

  16. Studies of scintillator response to 60 MeV protons in a proton beam imaging system

    Directory of Open Access Journals (Sweden)

    Rydygier Marzena

    2015-09-01

    Full Text Available A Proton Beam Imaging System (ProBImS is under development at the Institute of Nuclear Physics, Polish Academy of Sciences (IFJ PAN. The ProBImS will be used to optimize beam delivery at IFJ PAN proton therapy facilities, delivering two-dimensional distributions of beam profiles. The system consists of a scintillator, optical tract and a sensitive CCD camera which digitally records the light emitted from the proton-irradiated scintillator. The optical system, imaging data transfer and control software have already been developed. Here, we report preliminary results of an evaluation of the DuPont Hi-speed thick back screen EJ 000128 scintillator to determine its applicability in our imaging system. In order to optimize the light conversion with respect to the dose locally deposited by the proton beam in the scintillation detector, we have studied the response of the DuPont scintillator in terms of linearity of dose response, uniformity of light emission and decay rate of background light after deposition of a high dose in the scintillator. We found a linear dependence of scintillator light output vs. beam intensity by showing the intensity of the recorded images to be proportional to the dose deposited in the scintillator volume.

  17. Negative ion beam characterisation in BATMAN by mini-STRIKE: Improved design and new measurements

    Science.gov (United States)

    Serianni, G.; Bonomo, F.; Brombin, M.; Cervaro, V.; Chitarin, G.; Cristofaro, S.; Delogu, R.; De Muri, M.; Fasolo, D.; Fonnesu, N.; Franchin, L.; Franzen, P.; Ghiraldelli, R.; Molon, F.; Muraro, A.; Pasqualotto, R.; Ruf, B.; Schiesko, L.; Tollin, M.; Veltri, P.

    2015-04-01

    The ITER project requires additional heating provided by two injectors of neutral beams resulting from the neutralisation of accelerated negative ions. To study and optimise negative ion production, the SPIDER test facility (particle energy 100keV; beam current 50A) is under construction in Padova, with the aim of testing beam characteristics and to verify the source proper operation. The SPIDER beam will be characterised by the instrumented calorimeter STRIKE, whose main components are one-directional carbon fibre carbon composite tiles. Some prototype tiles have been employed in 2012 as a small-scale version (mini-STRIKE) of the entire system to investigate the features of the beam from BATMAN at IPP-Garching. As the BATMAN beamlets are superposed at the measurement position, about 1m from the grounded grid, an actively cooled copper mask is located in front of the tiles; holes in the mask create an artificial beamlet structure. Recently the mini-STRIKE has been updated, taking into account the results obtained in the first campaign. In particular the spatial resolution of the system has been improved by increasing the number of the copper mask holes. Moreover a custom measurement system has been realized for the thermocouple signals and employed in BATMAN in view of its use in SPIDER. The present contribution gives a description of the new design of the system as well as of the thermocouple measurements system and its field test. A new series of measurements has been carried out in BATMAN. The BATMAN beam characterisation in different experimental conditions is presented.

  18. Negative ion beam characterisation in BATMAN by mini-STRIKE: Improved design and new measurements

    International Nuclear Information System (INIS)

    Serianni, G.; Brombin, M.; Cervaro, V.; Chitarin, G.; Delogu, R.; Fasolo, D.; Fonnesu, N.; Franchin, L.; Ghiraldelli, R.; Molon, F.; Pasqualotto, R.; Tollin, M.; Veltri, P.; Bonomo, F.; Cristofaro, S.; De Muri, M.; Franzen, P.; Ruf, B.; Schiesko, L.; Muraro, A.

    2015-01-01

    The ITER project requires additional heating provided by two injectors of neutral beams resulting from the neutralisation of accelerated negative ions. To study and optimise negative ion production, the SPIDER test facility (particle energy 100keV; beam current 50A) is under construction in Padova, with the aim of testing beam characteristics and to verify the source proper operation. The SPIDER beam will be characterised by the instrumented calorimeter STRIKE, whose main components are one-directional carbon fibre carbon composite tiles. Some prototype tiles have been employed in 2012 as a small-scale version (mini-STRIKE) of the entire system to investigate the features of the beam from BATMAN at IPP-Garching. As the BATMAN beamlets are superposed at the measurement position, about 1m from the grounded grid, an actively cooled copper mask is located in front of the tiles; holes in the mask create an artificial beamlet structure. Recently the mini-STRIKE has been updated, taking into account the results obtained in the first campaign. In particular the spatial resolution of the system has been improved by increasing the number of the copper mask holes. Moreover a custom measurement system has been realized for the thermocouple signals and employed in BATMAN in view of its use in SPIDER. The present contribution gives a description of the new design of the system as well as of the thermocouple measurements system and its field test. A new series of measurements has been carried out in BATMAN. The BATMAN beam characterisation in different experimental conditions is presented

  19. EPR/alanine dosimetry for two therapeutic proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Marrale, Maurizio, E-mail: maurizio.marrale@unipa.it [Dipartimento di Fisica e Chimica, Università di Palermo, Viale delle Scienze, Edificio 18, 90128 Palermo (Italy); Gruppo V Sezione INFN di Catania, Via Santa Sofia, 64, 95123 Catania (Italy); Carlino, Antonio [Dipartimento di Fisica e Chimica, Università di Palermo, Viale delle Scienze, Edificio 18, 90128 Palermo (Italy); EBG MedAustron GmbH, Marie Curie-Straße 5, A-2700 Wiener Neustadt (Austria); Gallo, Salvatore [Dipartimento di Fisica e Chimica, Università di Palermo, Viale delle Scienze, Edificio 18, 90128 Palermo (Italy); Gruppo V Sezione INFN di Catania, Via Santa Sofia, 64, 95123 Catania (Italy); Laboratorio PH3DRA, Dipartimento di Fisica e Astronomia, Università di Catania, Via Santa Sofia 64, 95123 Catania (Italy); Longo, Anna; Panzeca, Salvatore [Dipartimento di Fisica e Chimica, Università di Palermo, Viale delle Scienze, Edificio 18, 90128 Palermo (Italy); Gruppo V Sezione INFN di Catania, Via Santa Sofia, 64, 95123 Catania (Italy); Bolsi, Alessandra; Hrbacek, Jan; Lomax, Tony [Center for Proton Therapy, Paul Scherrer Institute, 5232 Villigen PSI (Switzerland)

    2016-02-01

    In this work the analysis of the electron paramagnetic resonance (EPR) response of alanine pellets exposed to two different clinical proton beams employed for radiotherapy is performed. One beam is characterized by a passive delivery technique and is dedicated to the eyes treatment (OPTIS2 beam line). Alanine pellets were irradiated with a 70 MeV proton beam corresponding to 35 mm range in eye tissue. We investigated how collimators with different sizes and shape used to conform the dose to the planned target volume influence the delivered dose. For this purpose we performed measurements with varying the collimator size (Output Factor) and the results were compared with those obtained with other dosimetric techniques (such as Markus chamber and diode detector). This analysis showed that the dosimeter response is independent of collimator diameter if this is larger than or equal to 10 mm. The other beam is characterized by an active spot-scanning technique, the Gantry1 beam line (maximum energy 230 MeV), and is used to treat deep-seated tumors. The dose linearity of alanine response in the clinical dose range was tested and the alanine dose response at selected locations in depth was measured and compared with the TPS planned dose in a quasi-clinical scenario. The alanine response was found to be linear in the dose in the clinical explored range (from 10 to 70 Gy). Furthermore, a depth dose profile in a quasi-clinical scenario was measured and compared to the dose computed by the Treatment Planning System PSIPLAN. The comparison of calibrated proton alanine measurements and TPS dose shows a difference under 1% in the SOBP and a “quenching” effect up to 4% in the distal part of SOBP. The positive dosimetric characteristics of the alanine pellets confirm the feasibility to use these detectors for “in vivo” dosimetry in clinical proton beams.

  20. EPR/alanine dosimetry for two therapeutic proton beams

    International Nuclear Information System (INIS)

    Marrale, Maurizio; Carlino, Antonio; Gallo, Salvatore; Longo, Anna; Panzeca, Salvatore; Bolsi, Alessandra; Hrbacek, Jan; Lomax, Tony

    2016-01-01

    In this work the analysis of the electron paramagnetic resonance (EPR) response of alanine pellets exposed to two different clinical proton beams employed for radiotherapy is performed. One beam is characterized by a passive delivery technique and is dedicated to the eyes treatment (OPTIS2 beam line). Alanine pellets were irradiated with a 70 MeV proton beam corresponding to 35 mm range in eye tissue. We investigated how collimators with different sizes and shape used to conform the dose to the planned target volume influence the delivered dose. For this purpose we performed measurements with varying the collimator size (Output Factor) and the results were compared with those obtained with other dosimetric techniques (such as Markus chamber and diode detector). This analysis showed that the dosimeter response is independent of collimator diameter if this is larger than or equal to 10 mm. The other beam is characterized by an active spot-scanning technique, the Gantry1 beam line (maximum energy 230 MeV), and is used to treat deep-seated tumors. The dose linearity of alanine response in the clinical dose range was tested and the alanine dose response at selected locations in depth was measured and compared with the TPS planned dose in a quasi-clinical scenario. The alanine response was found to be linear in the dose in the clinical explored range (from 10 to 70 Gy). Furthermore, a depth dose profile in a quasi-clinical scenario was measured and compared to the dose computed by the Treatment Planning System PSIPLAN. The comparison of calibrated proton alanine measurements and TPS dose shows a difference under 1% in the SOBP and a “quenching” effect up to 4% in the distal part of SOBP. The positive dosimetric characteristics of the alanine pellets confirm the feasibility to use these detectors for “in vivo” dosimetry in clinical proton beams.

  1. Capacitive beam position monitors for the low-β beam of the Chinese ADS proton linac

    Science.gov (United States)

    Zhang, Yong; Wu, Jun-Xia; Zhu, Guang-Yu; Jia, Huan; Xue, Zong-Heng; Zheng, Hai; Xie, Hong-Ming; Kang, Xin-Cai; He, Yuan; Li, Lin; Denard, Jean Claude

    2016-02-01

    Beam Position Monitors (BPMs) for the low-β beam of the Chinese Accelerator Driven Subcritical system (CADS) Proton linac are of the capacitive pick-up type. They provide higher output signals than that of the inductive type. This paper will describe the design and tests of the capacitive BPM system for the low-β proton linac, including the pick-ups, the test bench and the read-out electronics. The tests done with an actual proton beam show a good agreement between the measurements and the simulations in the time domain. Supported by National Natural Science Foundation of China (11405240) and “Western Light” Talents Training Program of Chinese Academy of Sciences

  2. Manufacturing of Three-dimensional Micro Structure Using Proton Beam

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Suonggyu; Kwon, Wontae [Seoul University, Seoul (Korea, Republic of)

    2015-04-15

    The diameter of a proton beam emanating from the MC-50 cyclotron is about 2?3 mm with Gaussian distribution. This widely irradiated proton beam is not suitable for semiconductor etching, precise positioning, and micromachining, which require a small spot. In this study, a beam cutting method using a microhole is proposed as an economical alternative. We produced a microhole with aspect ratio, average diameter, and thickness of 428, 21 μm, and 9 mm, respectively, for cutting the proton beam. By using this high-aspect-ratio microhole, we conducted machinability tests on microstructures with sizes of tens of μm. Additionally, the results of simulation using GEANT4 and those of the actual experiment were compared and analyzed. The outcome confirmed the possibility of implementing a micro process technology for the fabrication of three-dimensional microstructures of 20 micron units using the MC-50 cyclotron with the microhole.

  3. Beam intensity monitoring for the external proton beam at LAMPF

    International Nuclear Information System (INIS)

    Barrett, R.J.; Anderson, B.D.; Willard, H.B.; Anderson, A.N.; Jarmie, N.

    1975-07-01

    Three different intensity monitors were tested in the external proton beam at LAMPF, and together cover the entire range of beam currents available. A 800 kg Faraday cup was installed and used to measure the absolute intensity to better than 1 percent for beam currents up to several nanoamperes. A high gain ion chamber was used as part of the calibration procedure for the Faraday cup, and was found to be useful when monitoring very small beam intensities, being reliable down to the few picoampere level. A secondary emission monitor was also tested, calibrated, and found to be trustworthy only for beams of greater than 50 pA intensity. (auth)

  4. Binary codes storage and data encryption in substrates with single proton beam writing technology

    International Nuclear Information System (INIS)

    Zhang Jun; Zhan Furu; Hu Zhiwen; Chen Lianyun; Yu Zengliang

    2006-01-01

    It has been demonstrated that characters can be written by proton beams in various materials. In contributing to the rapid development of proton beam writing technology, we introduce a new method for binary code storage and data encryption by writing binary codes of characters (BCC) in substrates with single proton beam writing technology. In this study, two kinds of BCC (ASCII BCC and long bit encrypted BCC) were written in CR-39 by a 2.6 MeV single proton beam. Our results show that in comparison to directly writing character shapes, writing ASCII BCC turned out to be about six times faster and required about one fourth the area in substrates. The approach of writing long bit encrypted BCC by single proton beams supports preserving confidential information in substrates. Additionally, binary codes fabricated by MeV single proton beams in substrates are more robust than those formed by lasers, since MeV single proton beams can make much deeper pits in the substrates

  5. Shielding calculation of slow extracted beam facility at KEK proton synchrotron

    International Nuclear Information System (INIS)

    Hirabayashi, Hiromi; Katoh, Kazuaki

    1978-01-01

    The KEK proton synchrotron has two external beam lines, i.e. a fast extracted beam line for a bubble chamber and a slow extracted beam line for counter experiments. The maximum total intensity of the slow beam is estimated as 5 x 10 12 protons per sec. For beam losses along the line, shielding calculation was made, and on the basis of these results, adequacy of the current shielding construction plans was discussed. (Mori, K.)

  6. Induction of cancer cell death by proton beam in tumor hypoxic region

    International Nuclear Information System (INIS)

    Hur, T. R.; Lee, Y. M.; Park, J. W.; Sohn, E. J.

    2006-05-01

    The physical properties of charged particles such as protons are uniquely suited to target the radiation dose precisely in the tumor. In proton therapy, the Bragg peak is spread out by modulating or degrading the energy of the particles to cover a well defined target volume at a given depth. Due to heterogeneity in the various tumors and end-points as well as in the physical properties of the beams considered, it is difficult to fit the various results into a clear general description of the biological effect of proton in tumor therapy. Tumor hypoxia is a main obstacle to radiotherapy, including gamma-ray. Survived tumor cells under hypoxic region are resistant to radiation and more aggressive to be metastasized. To investigate the dose of proton beam to induce cell death of various tumor cells and hypoxic tumor cells at the Bragg peak in vitro, we used 3 kinds of tumor cells, lung cancer, leukemia and hepatoma cells. Proton beam induces apoptosis in Lewis lung carcinoma cells dose dependently and, slightly in leukemia but not in hepatoma cells at all. Above 1000 gray of proton beam, 60% of cells died even the hypoxic cells in Lewis lung carcinoma cells. But the Molt-4 leukemia cells showed milder effect, 20% cell death by the above 1000 Gray of proton beam and typical resistant pattern (5-10%) of hypoxia in desferrioxamine treated cells. Hepatoma cells (HepG2) were not responsive to proton beam even in rather higher dose (4000G). However, by the gamma-irradiation, Molt-4 was more sensitive than hepatoma or lung cancer cells, but still showed hypoxic resistance. The cell death by proton beam in Lewis lung carcinoma cells was confirmed by PARP cleavage and may be mediated by increased p53. Pro-caspases were also activated and cleaved by the proton beam irradiations for lung cancer cell death. In conclusion, high dose of proton beam (above 1000 gray) may be a good therapeutic radiation even in hypoxic region at the Bragg peak, but further investigations about the

  7. A Liquid Scintillator System for Dosimetry of Photon and Proton Beams

    International Nuclear Information System (INIS)

    Beddar S

    2010-01-01

    We have developed a 3D system based on liquid scintillator (LS) for the dosimetry of photon and proton therapy. We have validated the LS detector system for fast and accurate quality assurance of IMRT and proton therapy fields. Further improvements are required to optimize the quantitative analysis of the light output provided by the system in photon beams. We have also demonstrated its usefulness for protons as it can determine the position and the range of proton beams. This system has also been shown to be capable of fast, sub-millimeter spatial localization of proton spots delivered in a 3D volume and could be used for quality assurance of IMPT. Further developments are on-going to measure beam intensities in 3D.

  8. Review of medical radiography and tomography with proton beams

    Science.gov (United States)

    Johnson, Robert P.

    2018-01-01

    The use of hadron beams, especially proton beams, in cancer radiotherapy has expanded rapidly in the past two decades. To fully realize the advantages of hadron therapy over traditional x-ray and gamma-ray therapy requires accurate positioning of the Bragg peak throughout the tumor being treated. A half century ago, suggestions had already been made to use protons themselves to develop images of tumors and surrounding tissue, to be used for treatment planning. The recent global expansion of hadron therapy, coupled with modern advances in computation and particle detection, has led several collaborations around the world to develop prototype detector systems and associated reconstruction codes for proton computed tomography (pCT), as well as more simple proton radiography, with the ultimate intent to use such systems in clinical treatment planning and verification. Recent imaging results of phantoms in hospital proton beams are encouraging, but many technical and programmatic challenges remain to be overcome before pCT scanners will be introduced into clinics. This review introduces hadron therapy and the perceived advantages of pCT and proton radiography for treatment planning, reviews its historical development, and discusses the physics related to proton imaging, the associated experimental and computation issues, the technologies used to attack the problem, contemporary efforts in detector and computational development, and the current status and outlook.

  9. Development of a reusable beam profile analyzer for laser accelerated proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Frydrych, Simon; Busold, Simon; Deppert, Oliver; Roth, Markus [Technische Univ. Darmstadt (Germany). Inst. fuer Kernphysik

    2013-07-01

    At the GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, proton beams are generated with the PHELIX laser system through target normal sheath acceleration (TNSA). Within 1 ps, 10{sup 13} protons are produced with an exponential energy spectrum up to 50 MeV. For characterisation, the spatial beam profile is currently detected by a stack of radiochromatic films (RCF). These are blued depending on the beam intensity. One disadvantage of RCFs is its one-time usability. Therefore, they shall be replaced by a scintillator array. To ensure the longest possible shelf life of this new detector, the scintillator material used must be very robust against radiation damage. Also a point of current research is the maximal amount of particles, which can be detected separately.

  10. Development of an energy selector system for laser-driven proton beam applications

    Energy Technology Data Exchange (ETDEWEB)

    Scuderi, V., E-mail: scuderiv@lns.infn.it [Department of Experimental Program at ELI-Beamlines, Institute of Physics of the ASCR, ELI-Beamlines project, Na Slovance 2, Prague (Czech Republic); Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Bijan Jia, S. [Ferdowsi University of Mashhad, Azadi Square, Mashhad (Iran, Islamic Republic of); Carpinelli, M. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Cirrone, G.A.P. [Department of Experimental Program at ELI-Beamlines, Institute of Physics of the ASCR, ELI-Beamlines project, Na Slovance 2, Prague (Czech Republic); Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Cuttone, G. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Korn, G. [Department of Experimental Program at ELI-Beamlines, Institute of Physics of the ASCR, ELI-Beamlines project, Na Slovance 2, Prague (Czech Republic); Licciardello, T. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Maggiore, M. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Viale dell' Universit 2, Legnaro (Pd) (Italy); Margarone, D. [Department of Experimental Program at ELI-Beamlines, Institute of Physics of the ASCR, ELI-Beamlines project, Na Slovance 2, Prague (Czech Republic); Pisciotta, P.; Romano, F. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Schillaci, F. [Department of Experimental Program at ELI-Beamlines, Institute of Physics of the ASCR, ELI-Beamlines project, Na Slovance 2, Prague (Czech Republic); Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Stancampiano, C. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); and others

    2014-03-11

    Nowadays, laser-driven proton beams generated by the interaction of high power lasers with solid targets represent a fascinating attraction in the field of the new acceleration techniques. These beams can be potentially accelerated up to hundreds of MeV and, therefore, they can represent a promising opportunity for medical applications. Laser-accelerated proton beams typically show high flux (up to 10{sup 11} particles per bunch), very short temporal profile (ps), broad energy spectra and poor reproducibility. In order to overcome these limitations, these beams have be controlled and transported by means of a proper beam handling system. Furthermore, suitable dosimetric diagnostic systems must be developed and tested. In the framework of the ELIMED project, we started to design a dedicated beam transport line and we have developed a first prototype of a beam line key-element: an Energy Selector System (ESS). It is based on permanent dipoles, capable to control and select in energy laser-accelerated proton beams. Monte Carlo simulations and some preliminary experimental tests have been already performed to characterize the device. A calibration of the ESS system with a conventional proton beam will be performed in September at the LNS in Catania. Moreover, an experimental campaign with laser-driven proton beam at the Centre for Plasma Physics, Queens University in Belfast is already scheduled and will be completed within 2014.

  11. A beam optics study of the biomedical beam line at a proton therapy facility

    International Nuclear Information System (INIS)

    Yun, Chong Cheoul; Kim, Jong-Won

    2007-01-01

    A biomedical beam line has been designed for the experimental area of a proton therapy facility to deliver mm to sub-mm size beams in the energy range of 20-50 MeV using the TRANSPORT/TURTLE beam optics codes and a newly-written program. The proton therapy facility is equipped with a 230 MeV fixed-energy cyclotron and an energy selection system based on a degrader and slits, so that beam currents available for therapy decrease at lower energies in the therapeutic beam energy range of 70-230 MeV. The new beam line system is composed of an energy-degrader, two slits, and three quadrupole magnets. The minimum beam sizes achievable at the focal point are estimated for the two energies of 50 and 20 MeV. The focused FWHM beam size is approximately 0.3 mm with an expected beam current of 20 pA when the beam energy is reduced to 50 MeV from 100 MeV, and roughly 0.8 mm with a current of 10 pA for a 20 MeV beam

  12. Transport of laser accelerated proton beams and isochoric heating of matter

    International Nuclear Information System (INIS)

    Roth, M; Alber, I; Guenther, M; Harres, K; Bagnoud, V; Brown, C; Gregori, G; Clarke, R; Heathcote, R; Li, B; Daido, H; Fernandez, J; Flippo, K; Gaillard, S; Gauthier, C; Glenzer, S; Kritcher, A; Kugland, N; LePape, S; Makita, M

    2010-01-01

    The acceleration of intense proton and ion beams by ultra-intense lasers has matured to a point where applications in basic research and technology are being developed. Crucial for harvesting the unmatched beam parameters driven by the relativistic electron sheath is the precise control of the beam. We report on recent experiments using the PHELIX laser at GSI, the VULCAN laser at RAL and the TRIDENT laser at LANL to control and use laser accelerated proton beams for applications in high energy density research. We demonstrate efficient collimation of the proton beam using high field pulsed solenoid magnets, a prerequisite to capture and transport the beam for applications. Furthermore we report on two campaigns to use intense, short proton bunches to isochorically heat solid targets up to the warm dense matter state. The temporal profile of the proton beam allows for rapid heating of the target, much faster than the hydrodynamic response time thereby creating a strongly coupled plasma at solid density. The target parameters are then probed by X-ray Thomson scattering (XRTS) to reveal the density and temperature of the heated volume. This combination of two powerful techniques developed during the past few years allows for the generation and investigation of macroscopic samples of matter in states present in giant planets or the interior of the earth.

  13. Transport of laser accelerated proton beams and isochoric heating of matter

    Energy Technology Data Exchange (ETDEWEB)

    Roth, M; Alber, I; Guenther, M; Harres, K [Inst. fuer Kernphysik, Technische Universitaet Darmstadt, 64289 Darmstadt (Germany); Bagnoud, V [GSI Helmholtzzentrum f. Schwerionenforschung GmbH, 64291 Darmstadt (Germany); Brown, C; Gregori, G [Clarendon Laboratory, University of Oxford, Parks Road, Oxford OX1 3PU (United Kingdom); Clarke, R; Heathcote, R; Li, B [STFC, Rutherford Appleton Laboratory, Chilton, Didcot, OX14 OQX (United Kingdom); Daido, H [Photo Medical Research Center, JAEA, Kizugawa-City, Kyoto 619-0215 (Japan); Fernandez, J; Flippo, K; Gaillard, S; Gauthier, C [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Glenzer, S; Kritcher, A; Kugland, N; LePape, S [Lawrence Livermore National Laboratory, Livermore, California 94551 (United States); Makita, M, E-mail: markus.roth@physik.tu-darmstadt.d [School of Mathematics and Physics, Queen' s University of Belfast, Belfast BT7 1NN (United Kingdom)

    2010-08-01

    The acceleration of intense proton and ion beams by ultra-intense lasers has matured to a point where applications in basic research and technology are being developed. Crucial for harvesting the unmatched beam parameters driven by the relativistic electron sheath is the precise control of the beam. We report on recent experiments using the PHELIX laser at GSI, the VULCAN laser at RAL and the TRIDENT laser at LANL to control and use laser accelerated proton beams for applications in high energy density research. We demonstrate efficient collimation of the proton beam using high field pulsed solenoid magnets, a prerequisite to capture and transport the beam for applications. Furthermore we report on two campaigns to use intense, short proton bunches to isochorically heat solid targets up to the warm dense matter state. The temporal profile of the proton beam allows for rapid heating of the target, much faster than the hydrodynamic response time thereby creating a strongly coupled plasma at solid density. The target parameters are then probed by X-ray Thomson scattering (XRTS) to reveal the density and temperature of the heated volume. This combination of two powerful techniques developed during the past few years allows for the generation and investigation of macroscopic samples of matter in states present in giant planets or the interior of the earth.

  14. Thermomechanical response of Large Hadron Collider collimators to proton and ion beam impacts

    Directory of Open Access Journals (Sweden)

    Marija Cauchi

    2015-04-01

    Full Text Available The CERN Large Hadron Collider (LHC is designed to accelerate and bring into collision high-energy protons as well as heavy ions. Accidents involving direct beam impacts on collimators can happen in both cases. The LHC collimation system is designed to handle the demanding requirements of high-intensity proton beams. Although proton beams have 100 times higher beam power than the nominal LHC lead ion beams, specific problems might arise in case of ion losses due to different particle-collimator interaction mechanisms when compared to protons. This paper investigates and compares direct ion and proton beam impacts on collimators, in particular tertiary collimators (TCTs, made of the tungsten heavy alloy INERMET® 180. Recent measurements of the mechanical behavior of this alloy under static and dynamic loading conditions at different temperatures have been done and used for realistic estimates of the collimator response to beam impact. Using these new measurements, a numerical finite element method (FEM approach is presented in this paper. Sequential fast-transient thermostructural analyses are performed in the elastic-plastic domain in order to evaluate and compare the thermomechanical response of TCTs in case of critical beam load cases involving proton and heavy ion beam impacts.

  15. Dosimetry of medical proton beams at the JINR phasotron in Dubna

    International Nuclear Information System (INIS)

    Kovar, I.; Spurny, F.; Wagner, R.; Molokanov, A.G.; Mitsyn, G.V.; Zorin, V.P.

    1993-01-01

    The method for determination of the dose rate absorbed by tissue for JINR phasotron medical proton beams on a basis of clinical dosimeter calibration with the 60 Co γ-source, the main parameters of detectors used for measurements of spatial dose distributions, results of ion recombination correction factors in air thimble ionization chambers measurements are described. It is found that the error of JINR phasotron proton beams dosimetry is about 5%. This accuracy meets the international requirements for the therapeutic proton beams. 15 refs.; 4 figs

  16. Impact of beam angle choice on pencil beam scanning breath-hold proton therapy for lung lesions

    DEFF Research Database (Denmark)

    Gorgisyan, Jenny; Perrin, Rosalind; Lomax, Antony J

    2017-01-01

    INTRODUCTION: The breath-hold technique inter alia has been suggested to mitigate the detrimental effect of motion on pencil beam scanned (PBS) proton therapy dose distributions. The aim of this study was to evaluate the robustness of incident proton beam angles to day-to-day anatomical variation...

  17. Off-axis dose equivalent due to secondary neutrons from uniform scanning proton beams during proton radiotherapy

    Science.gov (United States)

    Islam, M. R.; Collums, T. L.; Zheng, Y.; Monson, J.; Benton, E. R.

    2013-11-01

    The production of secondary neutrons is an undesirable byproduct of proton therapy and it is important to quantify the contribution from secondary neutrons to patient dose received outside the treatment volume. The purpose of this study is to investigate the off-axis dose equivalent from secondary neutrons experimentally using CR-39 plastic nuclear track detectors (PNTD) at ProCure Proton Therapy Center, Oklahoma City, OK. In this experiment, we placed several layers of CR-39 PNTD laterally outside the treatment volume inside a phantom and in air at various depths and angles with respect to the primary beam axis. Three different proton beams with max energies of 78, 162 and 226 MeV and 4 cm modulation width, a 5 cm diameter brass aperture, and a small snout located 38 cm from isocenter were used for the entire experiment. Monte Carlo simulations were also performed based on the experimental setup using a simplified snout configuration and the FLUKA Monte Carlo radiation transport code. The measured ratio of secondary neutron dose equivalent to therapeutic primary proton dose (H/D) ranged from 0.3 ± 0.08 mSv Gy-1 for 78 MeV proton beam to 37.4 ± 2.42 mSv Gy-1 for 226 MeV proton beam. Both experiment and simulation showed a similar decreasing trend in dose equivalent with distance to the central axis and the magnitude varied by a factor of about 2 in most locations. H/D was found to increase as the energy of the primary proton beam increased and higher H/D was observed at 135° compared to 45° and 90°. The overall higher H/D in air indicates the predominance of external neutrons produced in the nozzle rather than inside the body.

  18. Off-axis dose equivalent due to secondary neutrons from uniform scanning proton beams during proton radiotherapy

    International Nuclear Information System (INIS)

    Islam, M R; Collums, T L; Monson, J; Benton, E R; Zheng, Y

    2013-01-01

    The production of secondary neutrons is an undesirable byproduct of proton therapy and it is important to quantify the contribution from secondary neutrons to patient dose received outside the treatment volume. The purpose of this study is to investigate the off-axis dose equivalent from secondary neutrons experimentally using CR-39 plastic nuclear track detectors (PNTD) at ProCure Proton Therapy Center, Oklahoma City, OK. In this experiment, we placed several layers of CR-39 PNTD laterally outside the treatment volume inside a phantom and in air at various depths and angles with respect to the primary beam axis. Three different proton beams with max energies of 78, 162 and 226 MeV and 4 cm modulation width, a 5 cm diameter brass aperture, and a small snout located 38 cm from isocenter were used for the entire experiment. Monte Carlo simulations were also performed based on the experimental setup using a simplified snout configuration and the FLUKA Monte Carlo radiation transport code. The measured ratio of secondary neutron dose equivalent to therapeutic primary proton dose (H/D) ranged from 0.3 ± 0.08 mSv Gy −1  for 78 MeV proton beam to 37.4 ± 2.42 mSv Gy −1  for 226 MeV proton beam. Both experiment and simulation showed a similar decreasing trend in dose equivalent with distance to the central axis and the magnitude varied by a factor of about 2 in most locations. H/D was found to increase as the energy of the primary proton beam increased and higher H/D was observed at 135° compared to 45° and 90°. The overall higher H/D in air indicates the predominance of external neutrons produced in the nozzle rather than inside the body. (paper)

  19. High Intensity Beam Issues in the CERN Proton Synchrotron

    CERN Document Server

    Aumon, Sandra; Rivkin, Leonid

    This PhD work is about limitations of high intensity proton beams observed in the CERN Proton Synchrotron (PS) and, in particular, about issues at injection and transition energies. With its 53 years, the CERN PS would have to operate beyond the limit of its performance to match the future requirements. Beam instabilities driven by transverse impedance and aperture restrictions are important issues for the operation and for the High-Luminosity LHC upgrade which foresees an intensity increase delivered by the injectors. The main subject of the thesis concerns the study of a fast transverse instability occurring at transition energy. The proton beams crossing this energy range are particularly sensitive to wake forces because of the slow synchrotron motion. This instability can cause a strong vertical emittance blow-up and severe losses in less than a synchrotron period. Experimental observations show that the particles at the peak density of the beam longitudinal distribution oscillate in the vertical plane du...

  20. Dynamics and adsorption of gas molecules using proton beams

    International Nuclear Information System (INIS)

    Kim, J. Y.; Kim, E. K.; Lee, J. K.

    2008-04-01

    We irradiated nano sized MgO powders and carbon nanotubes by proton beams with energy of 35 MeV for different dosing time and the difference before and after the irradiation was investigated by using NO and Ar gas adsorptions studies. Particular interest was given to the irradiation of proton beams on quasicrystals made with Ti-Zr-Ni to remove the oxygen layer on the surface of the sample. Quasicrystals are known to exhibit a 5-fold rotational symmetry which is theoretically forbidden in a concept of solid state physics, and have a potential applications on large amount of hydrogen loading due to their structural complexity and chemical affinity with hydrogen. The results are summarized as four major accomplishments. 1) Proton irradiated MgO powders demonstrated the increased number of NO atomic layers in a layer-by-layer fashion suggesting that the surface of the sample became homogeneous compare to the pure samples. 2) the synchrotron based X-ray diffraction data suggests that NO molecules form an 1x1 commensurate structure on MgO (100) surface evidenced by the NO peak location at the Q values of 2.12 A -1 . 3) Proton irradiated SWCNTs exhibit the uniform Ar atomic layer formation suggesting that the surface of the CNTs can be homonized by the proton beam irradiation, and 4) 20 MeV of proton beam can effectively remove the oxygen layer on metal oxides so that Ti-Zr-Ni quasicrystals can load a large amount of hydrogen (exceeding to the density of liquid hydrogen) at room temperature.

  1. A Case Study in Proton Pencil-Beam Scanning Delivery

    International Nuclear Information System (INIS)

    Kooy, Hanne M.; Clasie, Benjamin M.; Lu, H.-M.; Madden, Thomas M.; Bentefour, Hassan; Depauw, Nicolas M.S.; Adams, Judy A.; Trofimov, Alexei V.; Demaret, Denis; Delaney, Thomas F.; Flanz, Jacob B.

    2010-01-01

    Purpose: We completed an implementation of pencil-beam scanning (PBS), a technology whereby a focused beam of protons, of variable intensity and energy, is scanned over a plane perpendicular to the beam axis and in depth. The aim of radiotherapy is to improve the target to healthy tissue dose differential. We illustrate how PBS achieves this aim in a patient with a bulky tumor. Methods and Materials: Our first deployment of PBS uses 'broad' pencil-beams ranging from 20 to 35 mm (full-width-half-maximum) over the range interval from 32 to 7 g/cm 2 . Such beam-brushes offer a unique opportunity for treating bulky tumors. We present a case study of a large (4,295 cc clinical target volume) retroperitoneal sarcoma treated to 50.4 Gy relative biological effectiveness (RBE) (presurgery) using a course of photons and protons to the clinical target volume and a course of protons to the gross target volume. Results: We describe our system and present the dosimetry for all courses and provide an interdosimetric comparison. Discussion: The use of PBS for bulky targets reduces the complexity of treatment planning and delivery compared with collimated proton fields. In addition, PBS obviates, especially for cases as presented here, the significant cost incurred in the construction of field-specific hardware. PBS offers improved dose distributions, reduced treatment time, and reduced cost of treatment.

  2. Analyzing power in inclusive π+ and π- production at high xF with a 200 GeV polarized proton beam

    International Nuclear Information System (INIS)

    Adams, D.L.; Bonner, B.E.; Buchanan, J.A.; Clement, J.M.; Corcoran, M.D.; Cranshaw, J.; Nessi-Tedaldi, F.; Nessi, M.; Nguyen, C.; Phillips, G.C.; Roberts, J.B.; Skeens, J.; White, J.L.; Akchurin, N.; Langland, J.; Onel, Y.; Belikov, N.I.; Derevschikov, A.A.; Grachov, O.A.; Matulenko, Yu.A.; Meschanin, A.P.; Nurushev, S.B.; Patalakha, D.I.; Rykov, V.L.; Solovyanov, V.L.; Vasiliev, A.N.; Bystricky, J.; Lehar, F.; Lesquen, A. de; Cossairt, J.D.; Read, A.L.; En'yo, H.; Funahashi, H.; Goto, Y.; Imai, K.; Itow, Y.; Makino, S.; Masaike, A.; Miyake, K.; Nagamine, T.; Saito, N.; Yamashita, S.; Grosnick, D.P.; Hill, D.A.; Lopiano, D.; Ohashi, Y.; Spinka, H.; Stanek, R.W.; Underwood, D.G.; Yokosawa, A.; Iwatani, K.; Krueger, K.W.; Kuroda, K.; Michalowicz, A.; Luehring, F.C.; Miller, D.H.; Maki, T.; Pauletta, G.; Penzo, A.; Schiavon, P.; Zanetti, A.; Van Rossum, L.; Salvato, G.; Villari, A.; Takashima, R.; Takeutchi, F.; Tamura, N.; Tanaka, N.; Yoshida, T.

    1991-01-01

    The analyzing power in inclusive charged pion production has been measured using the 200 GeV Fermilab polarized proton beam. A striking dependence in χ F is observed in which A N increases from 0 to 0.42 with increasing χ F for the π + data and decreases from 0 to -0.38 with increasing χ F for π - data. The kinematic range covered is 0.2≤χ F ≤0.9 and 0.2≤p T ≤2.0 GeV/c. In a simple model our data indicate that at large χ F the transverse spin of the proton is correlated with that of its quark constituents. (orig.)

  3. Target experiments with high-power proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Baumung, K; Bluhm, H; Hoppe, P; Rusch, D; Singer, J; Stoltz, O [Forschungszentrum Karlsruhe (Germany); Kanel, G I; Razorenov, S V; Utkin, A V [Russian Academy of Sciences, Chernogolovka (Russian Federation). Inst. of Chemical Physics

    1997-12-31

    At the Karlsruhe Light Ion Facility KALE a pulsed high-power proton beam (50 ns, 0.15 TW/cm{sup 2}, 8 mm fwhm focus diameter, 1.7 MeV peak proton energy) is used to generate short, intense pressure pulses or to ablatively accelerate targets 10-100 {mu}m thick to velocities > 10 km/s. The velocity history of the rear target surface is recorded by line-imaging laser Doppler velocimetry with high spatial ({>=} 10 {mu}m) and temporal ({>=} 200 ps) resolution, and provides information on proton beam parameters, and on the state of the matter at high energy densities and intense loading. Utilizing the bell-shaped power density profile the authors demonstrated a new straightforward method for measuring the shock pressure that leads to material melting in the rarefaction wave. For the first time, the dynamic tensile strength was measured across a crystal grain boundary, and using targets with a 1D periodic structure, the growth rate of a Rayleigh Taylor instability could be measured for the first time in direct drive experiments with an ion beam. (author). 8 figs., 15 refs.

  4. The study of PDMS surface treatment and it's applications by using proton beam

    International Nuclear Information System (INIS)

    Baek, J. Y.; Kim, J. Y.; Kwon, K. H.; Park, J. Y.

    2007-04-01

    PDMS(Polydimethylsiloxane) is mainly used as a material to do lab on a chip for biochemical analysis. PDMS has many applicability at the Bio-Technology(BT) field, because it is flexible, biocompatible and has good oxygen permeability. In this study, we have investigated to physical and chemical changes of PDMS surface by proton beam radiation conditions. The used kind of ion were Ar and N, beam energy was 30keV, 60keV, 80keV, total fluence was 1E10 to 1E16 [ions/cm 2 ]. PDMS membrane was produced as 150 μm thick on the 3' silicon wafer. We inquired into physical and chemical changes up to beam radiation conditions through the investigate the change of surface roughness by AFM(Atomic Force Microscope), the change of surface morphology by SEM(Scanning Electron Microscope) and the change of chemical composition by FT-IR(Fourier Transform Infrared Raman spectroscopy) and XPS(X-ray Photoelectron Spectroscopy). From these basic data to we set up the proton beam radiation conditions to secure metal layer and PDMS adhesion. This enables to produce the electrode at the PDMS material lab on a chip. From now on, we'll investigate the cell patterning possibility after carry out of cell culture with mouse fibroblast at PDMS surface what is surface modification by using of proton beam radiation and apply this to produce lab on a chip. Physical property: Surface roughness of PDMS membrane was observed using AFM, after exposure of proton beam on it. The roughness increased as the power level of proton beam increase. This phenomena was caused by the kinetic energy of particle. Chemical property: Long term observation was conducted on the contact angles of the samples made by the proton beam exposure or oxygen plasma treatment; the hydrophilicity was found to be stronger in the samples made by the proton beam exposure. We found the reason of this was the destruction of polymer chains by proton beam. Feasibility of Through-hole: Considering that comparatively high level energy beam

  5. Micro-patterns fabrication using focused proton beam lithography

    Energy Technology Data Exchange (ETDEWEB)

    Cutroneo, M., E-mail: cutroneo@ujf.cas.cz [Nuclear Physics Institute, AS CR, 25068 Rez (Czech Republic); Havranek, V. [Nuclear Physics Institute, AS CR, 25068 Rez (Czech Republic); Mackova, A. [Nuclear Physics Institute, AS CR, 25068 Rez (Czech Republic); Department of Physics, Faculty of Science, J.E. Purkinje University, Ceske mladeze 8, 400 96 Usti nad Labem (Czech Republic); Semian, V. [Nuclear Physics Institute, AS CR, 25068 Rez (Czech Republic); Torrisi, L. [Department of Physics and Earth Sciences, Messina University, V.le F.S. d’Alcontres 31, 98166 S. Agata, Messina (Italy); Calcagno, L. [Department of Physics, Catania University, V. S. Sofia 64, 95123 Catania (Italy)

    2016-03-15

    Proton beam writing technique was recently introduced at 3MV Tandetron accelerator at Nuclear Physics Institute in Rez (Czech Republic). It has been used, to produce three-dimensional (3D) micro-structures in poly(methylmethacrylate) by 2.0 MeV and 2.6 MeV protons micro-beam. Micro-channels (52 μm × 52 μm) have been realized. After chemical etching, the quality of the bottom and side walls of the produced structures in PMMA were analyzed using Scanning Transmission Ion Microscopy (STIM).

  6. Induction of cancer cell death by proton beam in tumor hypoxic region

    International Nuclear Information System (INIS)

    Lee, Y. M.; Hur, T. R.; Lee, K. B.; Jeong, M. H.; Park, J. W.

    2007-04-01

    Proton beam induced apoptosis significantly in Lewis lung carcinoma cells and hepatoma HepG2 cells in a dose- and time-dependent manner, but slightly in leukemia Molt-4 cells. Relative biological effectiveness (RBE) values for death rate relative to gamma ray were ranged from 1.3 to 2.1 in LLC or HepG2 but 0.7 in Molt-4 cells at 72h after irradiation. The typical apoptosis was observed by nuclear DNA staining with DAPI. By FACS analysis after stained with PI, sub-G1 cell fraction was significantly increased but G2/M phase was not altered by proton beam irradiation measured at 24 h after irradiation. Proton beam-irradiated tumor cells induced cleavage of PARP-1 and procaspases (-3 and -9) and increased the level of p53 and p21. decreased pro-lamin B. Acitivity of caspases was significantly increased after proton beam irradiation. Furthermore, ROS were significantly increased and N-acetyl cystein (NAC) pretreatment restored the apoptotic cell death induced in proton beam-irradiated cells. In conclusion, single treatment of low energy proton beam with SOBP induced apoptosis of solid tumor cells via increased ROS, active caspase -3,-9 and p53, p2

  7. Induction of cancer cell death by proton beam in tumor hypoxic region

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Y. M.; Hur, T. R.; Lee, K. B.; Jeong, M. H.; Park, J. W. [Kyungbook National Univ., Daegu (Korea, Republic of)

    2007-04-15

    Proton beam induced apoptosis significantly in Lewis lung carcinoma cells and hepatoma HepG2 cells in a dose- and time-dependent manner, but slightly in leukemia Molt-4 cells. Relative biological effectiveness (RBE) values for death rate relative to gamma ray were ranged from 1.3 to 2.1 in LLC or HepG2 but 0.7 in Molt-4 cells at 72h after irradiation. The typical apoptosis was observed by nuclear DNA staining with DAPI. By FACS analysis after stained with PI, sub-G1 cell fraction was significantly increased but G2/M phase was not altered by proton beam irradiation measured at 24 h after irradiation. Proton beam-irradiated tumor cells induced cleavage of PARP-1 and procaspases (-3 and -9) and increased the level of p53 and p21. decreased pro-lamin B. Acitivity of caspases was significantly increased after proton beam irradiation. Furthermore, ROS were significantly increased and N-acetyl cystein (NAC) pretreatment restored the apoptotic cell death induced in proton beam-irradiated cells. In conclusion, single treatment of low energy proton beam with SOBP induced apoptosis of solid tumor cells via increased ROS, active caspase -3,-9 and p53, p2.

  8. Maskless proton beam writing in gallium arsenide

    Energy Technology Data Exchange (ETDEWEB)

    Mistry, P. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom) and Nano-Electronics Centre, Advanced Technology Institute, University of Surrey, Guildford GU2 7XH (United Kingdom)]. E-mail: p.mistry@surrey.ac.uk; Gomez-Morilla, I. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Smith, R.C. [Nano-Electronics Centre, Advanced Technology Institute, University of Surrey, Guildford GU2 7XH (United Kingdom); Thomson, D. [Advanced Technology Institute, University of Surrey, Guildford GU2 7XH (United Kingdom); Grime, G.W. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Webb, R.P. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Gwilliam, R. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Jeynes, C. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Cansell, A. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Merchant, M. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Kirkby, K.J. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom)

    2007-07-15

    Proton beam writing (PBW) is a direct write technique that employs a focused MeV proton beam which is scanned in a pre-determined pattern over a target material which is subsequently electrochemically etched or chemically developed. By changing the energy of the protons the range of the protons can be changed. The ultimate depth of the structure is determined by the range of the protons in the material and this allows structures to be formed to different depths. PBW has been successfully employed on etchable glasses, polymers and semiconductor materials such as silicon (Si) and gallium arsenide (GaAs). This study reports on PBW in p-type GaAs and compares experimental results with computer simulations using the Atlas (copy right) semiconductor device package from SILVACO. It has already been proven that hole transport is required for the electrochemical etching of GaAs using Tiron (4,5-dihydroxy-m-benzenedisulfonic acid, di-sodium salt). PBW in GaAs results in carrier removal in the irradiated regions and consequently minimal hole transport (in these regions) during electrochemical etching. As a result the irradiated regions are significantly more etch resistant than the non-irradiated regions. This allows high aspect ratio structures to be formed.

  9. Maskless proton beam writing in gallium arsenide

    International Nuclear Information System (INIS)

    Mistry, P.; Gomez-Morilla, I.; Smith, R.C.; Thomson, D.; Grime, G.W.; Webb, R.P.; Gwilliam, R.; Jeynes, C.; Cansell, A.; Merchant, M.; Kirkby, K.J.

    2007-01-01

    Proton beam writing (PBW) is a direct write technique that employs a focused MeV proton beam which is scanned in a pre-determined pattern over a target material which is subsequently electrochemically etched or chemically developed. By changing the energy of the protons the range of the protons can be changed. The ultimate depth of the structure is determined by the range of the protons in the material and this allows structures to be formed to different depths. PBW has been successfully employed on etchable glasses, polymers and semiconductor materials such as silicon (Si) and gallium arsenide (GaAs). This study reports on PBW in p-type GaAs and compares experimental results with computer simulations using the Atlas (copy right) semiconductor device package from SILVACO. It has already been proven that hole transport is required for the electrochemical etching of GaAs using Tiron (4,5-dihydroxy-m-benzenedisulfonic acid, di-sodium salt). PBW in GaAs results in carrier removal in the irradiated regions and consequently minimal hole transport (in these regions) during electrochemical etching. As a result the irradiated regions are significantly more etch resistant than the non-irradiated regions. This allows high aspect ratio structures to be formed

  10. Biophysical characterization of a relativistic proton beam for image-guided radiosurgery.

    Science.gov (United States)

    Yu, Zhan; Vanstalle, Marie; La Tessa, Chiara; Jiang, Guo-Liang; Durante, Marco

    2012-07-01

    We measured the physical and radiobiological characteristics of 1 GeV protons for possible applications in stereotactic radiosurgery (image-guided plateau-proton radiosurgery). A proton beam was accelerated at 1 GeV at the Brookhaven National Laboratory (Upton, NY) and a target in polymethyl methacrylate (PMMA) was used. Clonogenic survival was measured after exposures to 1-10 Gy in three mammalian cell lines. Measurements and simulations demonstrate that the lateral scattering of the beam is very small. The lateral dose profile was measured with or without the 20-cm plastic target, showing no significant differences up to 2 cm from the axis A large number of secondary swift protons are produced in the target and this leads to an increase of approximately 40% in the measured dose on the beam axis at 20 cm depth. The relative biological effectiveness at 10% survival level ranged between 1.0 and 1.2 on the beam axis, and was slightly higher off-axis. The very low lateral scattering of relativistic protons and the possibility of using online proton radiography during the treatment make them attractive for image-guided plateau (non-Bragg peak) stereotactic radiosurgery.

  11. Biophysical characterization of a relativistic proton beam for image-guided radiosurgery

    International Nuclear Information System (INIS)

    Yu, Z.; Vanstalle, M.; La Tessa, C.; Durante, M.; Jiang Guoliang

    2012-01-01

    We measured the physical and radiobiological characteristics of 1 GeV protons for possible applications in stereotactic radiosurgery (image-guided plateau-proton radiosurgery). A proton beam was accelerated at 1 GeV at the Brookhaven National Laboratory (Upton, NY) and a target in polymethyl methacrylate (PMMA) was used. Clonogenic survival was measured after exposures to 1-10 Gy in three mammalian cell lines. Measurements and simulations demonstrate that the lateral scattering of the beam is very small. The lateral dose profile was measured with or without the 20-cm plastic target, showing no significant differences up to 2 cm from the axis A large number of secondary swift protons are produced in the target and this leads to an increase of approximately 40% in the measured dose on the beam axis at 20 cm depth. The relative biological effectiveness at 10% survival level ranged between 1.0 and 1.2 on the beam axis, and was slightly higher off-axis. The very low lateral scattering of relativistic protons and the possibility of using online proton radiography during the treatment make them attractive for image-guided plateau (non-Bragg peak) stereotactic radiosurgery. (author)

  12. Modified conductivity of polymer materials with proton beam

    International Nuclear Information System (INIS)

    Matsumoto, Shinji; Seki, Miharu; Shima, Kunihiro; Ishihara, Toyoyuki

    2001-01-01

    Ionic conductivity of polymer materials is of increasing interest in many scientific fields. Industrial applications seem to be promising. In the present investigation, we used proton bombardment to modify the characteristic properties of polymers, especially for improvement in conductivity and hardening gel polymers. Particle beam bombardment is known to produce many scissions by particle passages and new bonds by bridge connection. These effects may modify various properties in many ways. We examined the modification of conductivity in solid polymers composed of polyethylene oxide and polyurethane and the surface appearance of gel polymers with bombardment by a proton beam using the accelerator facility of Tsukuba University. The results indicated proton bombardment induced conductivity changes in various ways according to particle range and polymer properties. (author)

  13. Mutant breeding of ornamental trees for creating variations with high value using Proton Beam

    International Nuclear Information System (INIS)

    Kwon, H. J.; Lim, J. H.; Woo, S. M.; Hwang, M. J.; Pyo, S. H.; Woo, J. S.

    2009-04-01

    It is necessary to induce the improved strains of ornamental plants with more disease-resistant and useful for landscape or phytoremediation. Mutation breeding has played an important role in crop improvement, and more than 2,000 mutant cultivars have been released. For the induction of mutation, gamma rays and X-rays are widely used as a mutagen. Proton beam had higher energy than -ray and worked with localized strength, so that proton-beam radiation could be valuable tool to induce useful strains of ornamental plants. Proton ion beam irradiation was used to induce a useful mutant in rice, chrysanthemum, carnation, and so on in Japan. Also, proton ion beam was used to select a useful host strain, in polyhydroxybutyrate (PHB), a member of biodegradable plastic, could be overproduced in Korea. Therefore, we surmise that the effects of proton beam is different from those of gamma rays and X-rays, and we expect proton beam to be a new mutagen. This research was conducted to investigate the proton-beam radiation sensitivity and seed germination rate of the various ornamental plants like as Albizia julibrissin, Ficus religiosa, Rhus chinensis, Sorbaria sorbilfolia and Spiraea chinensis, to survey the quantitative characteristics of proton beam induced strains. To induce the variants of ornamental plants, seeds were irradiated at the dose of 0∼2kGy of proton beam at room temperature. Proton beam energy level was 45 MeV and was irradiated at dose of 0∼2kGy by MC-50 Cyclotron. After irradiation, to assess the effects of proton beam on radiation sensitivity and morphological changes of the plants and the seed germination rate were analysed. By the proton beam radiation, the germination rate decreased at the higher dose. The other hand, the germination rate of Rhus chinensis increased the dose higher, so that it need to investigate the germination rate over 2kGy radiation. The effects of mutation induction by proton beam irradiation on seeds in Lagerstroemia indica were

  14. Mutant breeding of ornamental trees for creating variations with high value using Proton Beam

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, H. J.; Lim, J. H.; Woo, S. M.; Hwang, M. J.; Pyo, S. H.; Woo, J. S. [Phygen Co., Daejeon (Korea, Republic of)

    2009-04-15

    It is necessary to induce the improved strains of ornamental plants with more disease-resistant and useful for landscape or phytoremediation. Mutation breeding has played an important role in crop improvement, and more than 2,000 mutant cultivars have been released. For the induction of mutation, gamma rays and X-rays are widely used as a mutagen. Proton beam had higher energy than -ray and worked with localized strength, so that proton-beam radiation could be valuable tool to induce useful strains of ornamental plants. Proton ion beam irradiation was used to induce a useful mutant in rice, chrysanthemum, carnation, and so on in Japan. Also, proton ion beam was used to select a useful host strain, in polyhydroxybutyrate (PHB), a member of biodegradable plastic, could be overproduced in Korea. Therefore, we surmise that the effects of proton beam is different from those of gamma rays and X-rays, and we expect proton beam to be a new mutagen. This research was conducted to investigate the proton-beam radiation sensitivity and seed germination rate of the various ornamental plants like as Albizia julibrissin, Ficus religiosa, Rhus chinensis, Sorbaria sorbilfolia and Spiraea chinensis, to survey the quantitative characteristics of proton beam induced strains. To induce the variants of ornamental plants, seeds were irradiated at the dose of 0{approx}2kGy of proton beam at room temperature. Proton beam energy level was 45 MeV and was irradiated at dose of 0{approx}2kGy by MC-50 Cyclotron. After irradiation, to assess the effects of proton beam on radiation sensitivity and morphological changes of the plants and the seed germination rate were analysed. By the proton beam radiation, the germination rate decreased at the higher dose. The other hand, the germination rate of Rhus chinensis increased the dose higher, so that it need to investigate the germination rate over 2kGy radiation. The effects of mutation induction by proton beam irradiation on seeds in Lagerstroemia

  15. Ablative acceleration of thin foil targets by intense proton beams

    International Nuclear Information System (INIS)

    Miyamoto, S.; Ozaki, T.; Imasaki, K.; Higaki, S.; Nakai, S.

    1981-01-01

    A focused proton beam of up to 2 x 10 10 w/cm 2 was obtained using pinch-reflex ion diode connected to Reiden IV generator. Experiments of beam target interaction have been done using thin foil targets. In this power range the interaction was explained classically. The experimental dependence of ablation pressure on proton beam intensity was obtained as P sub(a) = 3 x 10 -3 I sup(0.7) bar (I in w/cm 2 ). (author)

  16. A polarimeter for GeV protons of recirculating synchrotron beams

    CERN Document Server

    Bauer, F

    1999-01-01

    A polarimeter for use in recirculating beams of proton synchrotrons with energies from 300 MeV up to several GeV has been developed. The polarimetry is based on the asymmetry measurement of elastic p->p scattering on an internal CH sub 2 fiber target. The forward going protons are detected with two scintillator systems on either side of the beam pipe close to the angle THETA sub f of maximum analyzing power A sub N. Each one operates in coincidence with a broad (DELTA THETA sub b =21.4 deg. ), segmented detector system for the recoil proton of kinematically varying direction THETA sub b; this position resolution is also used for a concurrent measurement of the p->C and nonelastic p->p background. The CH sub 2 fiber can be replaced by a carbon fiber for detailed background studies; 'false' asymmetries are accounted for with a rotation of the polarimeter around the beam axis. Polarimetry has been performed in the internal beam of the Cooler Synchrotron COSY at fixed energies as well as during proton acceleratio...

  17. Proton beam induced dynamics of tungsten granules

    Science.gov (United States)

    Caretta, O.; Loveridge, P.; O'Dell, J.; Davenne, T.; Fitton, M.; Atherton, A.; Densham, C.; Charitonidis, N.; Efthymiopoulos, I.; Fabich, A.; Guinchard, M.; Lacny, L. J.; Lindstrom, B.

    2018-03-01

    This paper reports the results from single-pulse experiments of a 440 GeV /c proton beam interacting with granular tungsten samples in both vacuum and helium environments. Remote high-speed photography and laser Doppler vibrometry were used to observe the effect of the beam on the sample grains. The majority of the results were derived from a trough containing ˜45 μ m diameter spheres (not compacted) reset between experiments to maintain the same initial conditions. Experiments were also carried out on other open and contained samples for the purposes of comparison both with the 45 μ m grain results and with a previous experiment carried out with sub-250 μ m mixed crystalline tungsten powder in helium [Phys. Rev. ST Accel. Beams 17, 101005 (2014), 10.1103/PhysRevSTAB.17.101005]. The experiments demonstrate that a greater dynamic response is produced in a vacuum than in a helium environment and in smaller grains compared with larger grains. The examination of the dynamics of the grains after a beam impact leads to the hypothesis that the grain response is primarily the result of a charge interaction of the proton beam with the granular medium.

  18. Beam dynamics simulation of a double pass proton linear accelerator

    Directory of Open Access Journals (Sweden)

    Kilean Hwang

    2017-04-01

    Full Text Available A recirculating superconducting linear accelerator with the advantage of both straight and circular accelerator has been demonstrated with relativistic electron beams. The acceleration concept of a recirculating proton beam was recently proposed [J. Qiang, Nucl. Instrum. Methods Phys. Res., Sect. A 795, 77 (2015NIMAER0168-900210.1016/j.nima.2015.05.056] and is currently under study. In order to further support the concept, the beam dynamics study on a recirculating proton linear accelerator has to be carried out. In this paper, we study the feasibility of a two-pass recirculating proton linear accelerator through the direct numerical beam dynamics design optimization and the start-to-end simulation. This study shows that the two-pass simultaneous focusing without particle losses is attainable including fully 3D space-charge effects through the entire accelerator system.

  19. Proton-beam writing channel based on an electrostatic accelerator

    Science.gov (United States)

    Lapin, A. S.; Rebrov, V. A.; Kolin'ko, S. V.; Salivon, V. F.; Ponomarev, A. G.

    2016-09-01

    We have described the structure of the proton-beam writing channel as a continuation of a nuclear scanning microprobe channel. The problem of the accuracy of positioning a probe by constructing a new high-frequency electrostatic scanning system has been solved. Special attention has been paid to designing the probe-forming system and its various configurations have been considered. The probe-forming system that best corresponds to the conditions of the lithographic process has been found based on solving the problem of optimizing proton beam formation. A system for controlling beam scanning using multifunctional module of integrated programmable logic systems has been developed.

  20. Proton beam radiotherapy of choroidal melanoma: The Liverpool-Clatterbridge experience

    International Nuclear Information System (INIS)

    Damato, Bertil; Kacperek, Andrzej; Chopra, Mona; Campbell, Ian R.; Errington, R. Douglas

    2005-01-01

    Purpose To report on outcomes after proton beam radiotherapy of choroidal melanoma using a 62-MeV cyclotron in patients considered unsuitable for other forms of conservative therapy. Methods and Materials A total of 349 patients with choroidal melanoma referred to the Liverpool Ocular Oncology Centre underwent proton beam radiotherapy at Clatterbridge Centre for Oncology (CCO) between January 1993 and December 2003. Four daily fractions of proton beam radiotherapy were delivered, with a total dose of 53.1 proton Gy, and with lateral and distal safety margins of 2.5 mm. Outcomes measured were local tumor recurrence; ocular conservation; vision; and metastatic death according to age, gender, eye, visual acuity, location of anterior and posterior tumor margins, quadrant, longest basal tumor dimension, tumor height, extraocular extension, and retinal invasion. Results The 5-year actuarial rates were 3.5% for local tumor recurrence, 9.4% for enucleation, 79.1% for conservation of vision of counting fingers or better, 61.1% for conservation of vision of 20/200 or better, 44.8% for conservation of vision of 20/40 or better, and 10.0% for death from metastasis. Conclusion Proton beam radiotherapy with a 62 MeV cyclotron achieves high rates of local tumor control and ocular conservation, with visual outcome depending on tumor size and location

  1. Dynamics of laser-driven proton beam focusing and transport into solid density matter

    Science.gov (United States)

    Kim, J.; McGuffey, C.; Beg, F.; Wei, M.; Mariscal, D.; Chen, S.; Fuchs, J.

    2016-10-01

    Isochoric heating and local energy deposition capabilities make intense proton beams appealing for studying high energy density physics and the Fast Ignition of inertial confinement fusion. To study proton beam focusing that results in high beam density, experiments have been conducted using different target geometries irradiated by a kilojoule, 10 ps pulse of the OMEGA EP laser. The beam focus was measured by imaging beam-induced Cu K-alpha emission on a Cu foil that was positioned at a fixed distance. Compared to a free target, structured targets having shapes of wedge and cone show a brighter and narrower K-alpha radiation emission spot on a Cu foil indicating higher beam focusability. Experimentally observed images with proton radiography demonstrate the existence of transverse fields on the structures. Full-scale simulations including the contribution of a long pulse duration of the laser confirm that such fields can be caused by hot electrons moving through the structures. The simulated fields are strong enough to reflect the diverging main proton beam and pinch a transverse probe beam. Detailed simulation results including the beam focusing and transport of the focused intense proton beam in Cu foil will be presented. This work was supported by the National Laser User Facility Program through Award DE-NA0002034.

  2. Proton beam generation of whistler waves in the earth's foreshock

    Science.gov (United States)

    Wong, H. K.; Goldstein, M. L.

    1987-01-01

    It is shown that proton beams, often observed upstream of the earth's bow shock and associated with the generation of low-frequency hydromagnetic fluctuations, are also capable of generating whistler waves. The waves can be excited by an instability driven by two-temperature streaming Maxwellian proton distributions which have T (perpendicular)/T(parallel) much greater than 1. It can also be excited by gyrating proton beam distributions. These distributions generate whistler waves with frequencies ranging from 10 to 100 times the proton cyclotron frequency (in the solar wind reference frame) and provide another mechanism for generating the '1-Hz' waves often seen in the earth's foreshock.

  3. Proton beam generation of whistler waves in the Earth's foreshock

    International Nuclear Information System (INIS)

    Wong, H.K.; Goldstein, M.L.

    1987-01-01

    We show that proton beams, often observed upstream of the Earth's bow shock and associated with the generation of low-frequency hydromagnetic fluctuations, are also capable of generating whistler waves. The waves can be excited by an instability driven by two-temperature streaming Maxwellian proton distributions which have T/sub perpendicular//T/sub parallel/>>1. It can also be excited by gyrating proton beam distributions. These distributions generate whistler waves with frequencies ranging from 10 to 100 times the proton cyclotron frequency (in the solar wind reference frame) and provide another mechanism for generating the ''1-Hz'' waves often seen in the Earth's foreshock

  4. Structural design study of a proton beam window for a 1-MW spallation neutron source

    CERN Document Server

    Teraoku, T; Ishikura, S; Kaminaga, M; Maekawa, F; Meigo, S I; Terada, A

    2003-01-01

    A 1-MW spallation neutron source aiming at materials and life science researches will be constructed under the JAERI-KEK High-intensity Proton Accelerator Project (J-PARC). A proton beam passes through a proton beam window, and be injected into a target of the neutron source. The proton beam window functions as a boundary wall between a high vacuum area in the proton beam line and a helium atmosphere at about atmospheric pressure in a helium vessel which contains the target and moderators. The proton beam window is cooled by light water because high heat-density is generated in the window material by interactions with the proton beam. Then, uniformity of the water flow is requested at the window to suppress a hot-spot that causes excessive thermal stress and cooling water boiling. Also, the window has to be strong enough in its structure for inner stress due to water pressure and thermal stress due to heat generation. In this report, we propose two types of proton beam windows; one flat-type that is easy to m...

  5. Proton beam modification of lead white pigments

    International Nuclear Information System (INIS)

    Beck, L.; Gutiérrez, P.C.; Miserque, F.; Thomé, L.

    2013-01-01

    Pigments and paint materials are known to be sensitive to particle irradiation. Occasionally, the analysis of paintings by PIXE can induce a slight or dark stain depending on the experimental conditions (beam current, dose, particle energy). In order to understand this discoloration, we have irradiated various types of art white pigments – lead white (hydrocerussite and basic lead sulfate), gypsum, calcite, zinc oxide and titanium oxide – with an external 3 MeV proton micro-beam commonly used for PIXE experiments. We have observed various sensitivities depending on the pigment. No visible change occurs for calcite and titanium oxide, whereas lead white pigments are very sensitive. For the majority of the studied compounds, the discoloration is proportional to the beam current and charge. The damage induced by proton beam irradiation in lead white pigments was studied by micro-Raman and XPS spectroscopies. Structural modifications and dehydration were detected. Damage recovery was investigated by thermal treatment and UV-light irradiation. The discoloration disappeared after one week of UV illumination, showing that PIXE experiments could be safely undertaken for pigments and paintings

  6. Beam collimation and transport of laser-accelerated protons by a solenoid field

    Energy Technology Data Exchange (ETDEWEB)

    Harres, K; Alber, I; Guenther, M; Nuernberg, F; Otten, A; Schuetrumpf, J; Roth, M [Technische Universitaet Darmstadt, Institut fuer Kernphysik, Schlossgartenstrasse 9, 64289 Darmstadt (Germany); Tauschwitz, A; Bagnoud, V [GSI - Hemholtzzentrum fur Schwerionenforschung GmbH, Plasmaphysik and PHELIX, Planckstrasse 1, 64291 Darmstadt (Germany); Daido, H; Tampo, M [Photo Medical Research Center, JAEA, 8-1 Umemidai, Kizugawa-city, Kyoto, 619-0215 (Japan); Schollmeier, M, E-mail: k.harres@gsi.d [Sandia National Laboratories, Albuquerque NM 87185 (United States)

    2010-08-01

    A pulsed high field solenoid was used in a laser-proton acceleration experiment to collimate and transport the proton beam that was generated at the irradiation of a flat foil by a high intensity laser pulse. 10{sup 12} particles at an energy of 2.3 MeV could be caught and transported over a distance of more than 240 mm. Strong space charge effects occur, induced by the high field of the solenoid that forces all co-moving electrons down the the solenoid's axis, building up a strong negative space charge that interacts with the proton beam. This leads to an aggregation of the proton beam around the solenoid's axis and therefore to a stronger focusing effect. The collimation and transport of laser-accelerated protons is the first step to provide these unique beams for further applications like post-acceleration by conventional accelerator structures.

  7. Beam collimation and transport of laser-accelerated protons by a solenoid field

    International Nuclear Information System (INIS)

    Harres, K; Alber, I; Guenther, M; Nuernberg, F; Otten, A; Schuetrumpf, J; Roth, M; Tauschwitz, A; Bagnoud, V; Daido, H; Tampo, M; Schollmeier, M

    2010-01-01

    A pulsed high field solenoid was used in a laser-proton acceleration experiment to collimate and transport the proton beam that was generated at the irradiation of a flat foil by a high intensity laser pulse. 10 12 particles at an energy of 2.3 MeV could be caught and transported over a distance of more than 240 mm. Strong space charge effects occur, induced by the high field of the solenoid that forces all co-moving electrons down the the solenoid's axis, building up a strong negative space charge that interacts with the proton beam. This leads to an aggregation of the proton beam around the solenoid's axis and therefore to a stronger focusing effect. The collimation and transport of laser-accelerated protons is the first step to provide these unique beams for further applications like post-acceleration by conventional accelerator structures.

  8. Production of high-brightness continuous wave proton beams with very high proton fractions (abstract)a

    International Nuclear Information System (INIS)

    Spence, D.; McMichael, G.; Lykke, K.R.; Schneider, J.D.; Sherman, J.; Stevens, R. Jr.; Hodgkins, D.

    1996-01-01

    This article demonstrates a new technique to significantly enhance the proton fraction of an ion beam extracted from a plasma ion source. We employ a magnetically confined microwave driven source, though the technique is not source specific and can probably be applied equally effectively to other plasma sources such as Penning and multicusp types. Specifically, we dope the plasma with about 1% H 2 O, which increases the proton fraction of a 45 keV 45 mA beam from 75% to 90% with 375 W 2.45 GHz power to the source and from 84% to 92% for 500 W when the source is operated under nonresonant conditions. Much of the remaining fraction of the beam comprises a heavy mass ion we believe to be N + impurity ions resulting from the conditions under which the experiments were performed. If so, this impurity can easily be removed and much higher proton fractions could be expected. Preliminary measurements show the additive has no adverse effect on the emittance of the extracted beam, and source stability is greatly improved

  9. Direct measurement of the energy spectrum of an intense proton beam

    International Nuclear Information System (INIS)

    Leeper, R.J.; Lee, J.R.; Kissel, L.; Johnson, D.J.; Stygar, W.A.; Hebron, D.E.; Roose, L.D.

    1983-01-01

    A time-resolved magnetic spectrometer has been used to measure the energy spectrum of an intense (0.5 TW/cm 2 ) proton beam. A thin (2400 A) gold foil placed at the focus of an ion diode Rutherford scattered protons by 90 0 into the spectrometer, reducing the beam intensity to a level suitable for magnetic analysis. The scattered beam was collimated by two 1 mm diameter apertures separated by 12.3 cm. The collimated protons were deflected in a 12.7 cm diameter, 6.65 Kg samarium-cobalt permanent magnet. The deflected protons were recorded simultaneously on CR-39 and eight 1 mm 2 by 35 μm thick PIN diodes. A Monte Carlo computer code was used to calculate the sensitivity and resolution of the spectrometer. Data taken on Proto-I show a 150 keV to 250 keV wide proton energy spectrum at each instant in time

  10. Repeated proton beam therapy for hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Hashimoto, Takayuki; Tokuuye, Koichi; Fukumitsu, Nobuyoshi; Igaki, Hiroshi; Hata, Masaharu; Kagei, Kenji; Sugahara, Shinji; Ohara, Kiyoshi; Matsuzaki, Yasushi; Akine, Yasuyuki

    2006-01-01

    Purpose: To retrospectively evaluate the safety and effectiveness of repeated proton beam therapy for newly developed or recurrent hepatocellular carcinoma (HCC). Methods and Materials: From June 1989 through July 2000, 225 patients with HCC underwent their first course of proton beam therapy at University of Tsukuba. Of them, 27 with 68 lesions who had undergone two or more courses were retrospectively reviewed in this study. Median interval between the first and second course was 24.5 months (range 3.3-79.8 months). Median total dose of 72 Gy in 16 fractions and 66 Gy in 16 fractions were given for the first course and the rest of the courses, respectively. Results: The 5-year survival rate and median survival period from the beginning of the first course for the 27 patients were 55.6% and 62.2 months, respectively. Five-year local control rate for the 68 lesions was 87.8%. Of the patients, 1 with Child-Pugh class B and another with class C before the last course suffered from acute hepatic failure. Conclusions: Repeated proton beam therapy for HCC is safe when the patient has a target in the peripheral region of the liver and liver function is Child-Pugh class A

  11. Rhabdomyosarcoma of the trachea: first reported case treated with proton beam therapy.

    Science.gov (United States)

    Exley, R; Bernstein, J M; Brennan, B; Rothera, M P

    2012-09-01

    We report a case of rhabdomyosarcoma of the trachea in a 14-month-old child, and we present the first reported use of proton beam therapy for this tumour. A 14-month-old girl presented acutely with a seven-day history of biphasic stridor. Emergency endoscopic debulking of a posterior tracheal mass was undertaken. Histological examination revealed an embryonal rhabdomyosarcoma with anaplasia. Multimodality therapy with surgery and chemotherapy was administered in the UK, and proton beam therapy in the USA. Only three cases of rhabdomyosarcoma of the trachea have previously been reported in the world literature. This is the first reported case of treatment of this tumour with proton beam therapy. Compared with conventional radiotherapy, proton beam therapy may confer improved long-term outcome in children, with benefits including reduced irradiation of the spinal cord.

  12. Induced radioactivity in the target station and decay tunnel from a 4MW proton beam

    CERN Document Server

    Agosteo, S; Otto, T; Silari, Marco

    2003-01-01

    An important aspect of a future CERN Neutrino Factory is the material activation arising from a 2.2 GeV, 4 MW proton beam striking a mercury target. A first estimation of the hadronic inelastic interactions and the production of residual nuclei in the target, the magnetic horn, the decay tunnel, the surrounding rock and a downstream dump has been performed by the Monte Carlo hadronic cascade code FLUKA. The aim is both to assess the dose equivalent rate to be expected during maintenance work and to evaluate the amount of residual radioactivity, which will have to be disposed of after the facility has ceased operation. This paper discusses the first results of such calculations.

  13. Beam collimation and transport of quasineutral laser-accelerated protons by a solenoid field

    International Nuclear Information System (INIS)

    Harres, K.; Alber, I.; Guenther, M.; Nuernberg, F.; Otten, A.; Schuetrumpf, J.; Roth, M.; Tauschwitz, A.; Bagnoud, V.; Daido, H.; Tampo, M.; Schollmeier, M.

    2010-01-01

    This article reports about controlling laser-accelerated proton beams with respect to beam divergence and energy. The particles are captured by a pulsed high field solenoid with a magnetic field strength of 8.6 T directly behind a flat target foil that is irradiated by a high intensity laser pulse. Proton beams with energies around 2.3 MeV and particle numbers of 10 12 could be collimated and transported over a distance of more than 300 mm. In contrast to the protons the comoving electrons are strongly deflected by the solenoid field. They propagate at a submillimeter gyroradius around the solenoid's axis which could be experimentally verified. The originated high flux electron beam produces a high space charge resulting in a stronger focusing of the proton beam than expected by tracking results. Leadoff particle-in-cell simulations show qualitatively that this effect is caused by space charge attraction due to the comoving electrons. The collimation and transport of laser-accelerated protons is the first step to provide these unique beams for further applications such as postacceleration by conventional accelerator structures.

  14. Principles and practice of proton beam therapy

    CERN Document Server

    Das, Indra J

    2015-01-01

    Commissioned by The American Association of Physicists in Medicine (AAPM) for their June 2015 Summer School, this is the first AAPM monograph printed in full color. Proton therapy has been used in radiation therapy for over 70 years, but within the last decade its use in clinics has grown exponentially. This book fills in the proton therapy gap by focusing on the physics of proton therapy, including beam production, proton interactions, biology, dosimetry, treatment planning, quality assurance, commissioning, motion management, and uncertainties. Chapters are written by the world's leading medical physicists who work at the pioneering proton treatment centers around the globe. They share their understandings after years of experience treating thousands of patients. Case studies involving specific cancer treatments show that there is some art to proton therapy as well as state-of-the-art science. Even though the focus lies on proton therapy, the content provided is also valuable to heavy charged particle th...

  15. Clinical results of proton beam therapy for skull base chordoma

    International Nuclear Information System (INIS)

    Igaki, Hiroshi; Tokuuye, Koichi; Okumura, Toshiyuki; Sugahara, Shinji; Kagei, Kenji; Hata, Masaharu; Ohara, Kiyoshi; Hashimoto, Takayuki; Tsuboi, Koji; Takano, Shingo; Matsumura, Akira; Akine, Yasuyuki

    2004-01-01

    Purpose: To evaluate clinical results of proton beam therapy for patients with skull base chordoma. Methods and materials: Thirteen patients with skull base chordoma who were treated with proton beams with or without X-rays at the University of Tsukuba between 1989 and 2000 were retrospectively reviewed. A median total tumor dose of 72.0 Gy (range, 63.0-95.0 Gy) was delivered. The patients were followed for a median period of 69.3 months (range, 14.6-123.4 months). Results: The 5-year local control rate was 46.0%. Cause-specific, overall, and disease-free survival rates at 5 years were 72.2%, 66.7%, and 42.2%, respectively. The local control rate was higher, without statistical significance, for those with preoperative tumors <30 mL. Partial or subtotal tumor removal did not yield better local control rates than for patients who underwent biopsy only as the latest surgery. Conclusion: Proton beam therapy is effective for patients with skull base chordoma, especially for those with small tumors. For a patient with a tumor of <30 mL with no prior treatment, biopsy without tumor removal seems to be appropriate before proton beam therapy

  16. Proton beam induced dynamics of tungsten granules

    Directory of Open Access Journals (Sweden)

    O. Caretta

    2018-03-01

    Full Text Available This paper reports the results from single-pulse experiments of a 440  GeV/c proton beam interacting with granular tungsten samples in both vacuum and helium environments. Remote high-speed photography and laser Doppler vibrometry were used to observe the effect of the beam on the sample grains. The majority of the results were derived from a trough containing ∼45  μm diameter spheres (not compacted reset between experiments to maintain the same initial conditions. Experiments were also carried out on other open and contained samples for the purposes of comparison both with the 45  μm grain results and with a previous experiment carried out with sub-250  μm mixed crystalline tungsten powder in helium [Phys. Rev. ST Accel. Beams 17, 101005 (2014PRABFM1098-440210.1103/PhysRevSTAB.17.101005]. The experiments demonstrate that a greater dynamic response is produced in a vacuum than in a helium environment and in smaller grains compared with larger grains. The examination of the dynamics of the grains after a beam impact leads to the hypothesis that the grain response is primarily the result of a charge interaction of the proton beam with the granular medium.

  17. Proton external beam in the TANDAR Accelerator; Haz externo de protones en el acelerador TANDAR

    Energy Technology Data Exchange (ETDEWEB)

    Rey, R; Schuff, J A; Perez de la Hoz, A.; Debray, M E; Hojman, D; Kreiner, A J; Kesque, J M; Saint-Martin, G; Oppezzo, O; Bernaola, O A; Molinari, B L; Duran, H A; Policastro, L; Palmieri, M; Ibanez, J; Stoliar, P; Mazal, A; Caraballo, M E; Burlon, A; Cardona, M A; Vazquez, M E; Salfity, M F; Ozafran, M J; Naab, F; Levinton, G; Davidson, M; Buhler, M [Departamento de Fisica, Comision Nacional de Energia Atomica, Av. Gral. Paz 1499, C.P. 1650 San Martin, Buenos Aires (Argentina)

    1999-12-31

    An external proton beam has been obtained in the TANDAR accelerator with radiological and biomedical purposes. The protons have excellent physical properties for their use in radiotherapy allowing a very good accuracy in the dose spatial distribution inside the tissue so in the side direction as in depth owing to the presence of Bragg curve. The advantage of the accuracy in the dose localization with proton therapy is good documented (M. Wagner, Med. Phys. 9, 749 (1982); M. Goitein and F. Chen, Med. Phys. 10, 831 (1983); M.R. Raju, Rad. Res. 145, 391 (1996)). It was obtained external proton beams with energies between 15-25 MeV, currents between 2-10 p A and a uniform transversal sections of 40 mm{sup 2} approximately. It was realized dosimetric evaluations with CR39 and Makrofol foliation. The irradiations over biological material contained experiences In vivo with laboratory animals, cellular and bacterial crops. It was fixed the optimal conditions of position and immobilization of the Wistar rats breeding for the In vivo studies. It was chosen dilutions and sowing techniques adequate for the exposition at the cellular and bacterial crops beam. (Author)

  18. Proton external beam in the TANDAR Accelerator; Haz externo de protones en el acelerador TANDAR

    Energy Technology Data Exchange (ETDEWEB)

    Rey, R.; Schuff, J.A.; Perez de la Hoz, A.; Debray, M.E.; Hojman, D.; Kreiner, A.J.; Kesque, J.M.; Saint-Martin, G.; Oppezzo, O.; Bernaola, O.A.; Molinari, B.L.; Duran, H.A.; Policastro, L.; Palmieri, M.; Ibanez, J.; Stoliar, P.; Mazal, A.; Caraballo, M.E.; Burlon, A.; Cardona, M.A.; Vazquez, M.E.; Salfity, M.F.; Ozafran, M.J.; Naab, F.; Levinton, G.; Davidson, M.; Buhler, M. [Departamento de Fisica, Comision Nacional de Energia Atomica, Av. Gral. Paz 1499, C.P. 1650 San Martin, Buenos Aires (Argentina)

    1998-12-31

    An external proton beam has been obtained in the TANDAR accelerator with radiological and biomedical purposes. The protons have excellent physical properties for their use in radiotherapy allowing a very good accuracy in the dose spatial distribution inside the tissue so in the side direction as in depth owing to the presence of Bragg curve. The advantage of the accuracy in the dose localization with proton therapy is good documented (M. Wagner, Med. Phys. 9, 749 (1982); M. Goitein and F. Chen, Med. Phys. 10, 831 (1983); M.R. Raju, Rad. Res. 145, 391 (1996)). It was obtained external proton beams with energies between 15-25 MeV, currents between 2-10 p A and a uniform transversal sections of 40 mm{sup 2} approximately. It was realized dosimetric evaluations with CR39 and Makrofol foliation. The irradiations over biological material contained experiences In vivo with laboratory animals, cellular and bacterial crops. It was fixed the optimal conditions of position and immobilization of the Wistar rats breeding for the In vivo studies. It was chosen dilutions and sowing techniques adequate for the exposition at the cellular and bacterial crops beam. (Author)

  19. Microdosimetric investigation at the therapeutic proton beam facility of CATANA.

    Science.gov (United States)

    De Nardo, L; Moro, D; Colautti, P; Conte, V; Tornielli, G; Cuttone, G

    2004-01-01

    Proton beams (62 Mev) are used by the Laboratori Nazionali del Sud of the Italian Institute of Nuclear Physics to treat eye melanoma tumours at the therapeutic facility called CATANA. A cylindrical slim tissue-equivalent proportional counter (TEPC) of 2.7 mm external diameter has been used to compare the radiation quality of two spread-out Bragg peaks (SOBP) at the CATANA proton beam.

  20. Microdosimetric investigation at the therapeutic proton beam facility of Catana

    International Nuclear Information System (INIS)

    De Nardo, L.; Moro, D.; Colautti, P.; Conte, V.; Tornielli, G.; Cuttone, G.

    2004-01-01

    Proton beams (62 Mev) are used by the Laboratori Nazionali del Sud of the Italian Inst. of Nuclear Physics to treat eye melanoma tumours at the therapeutic facility called CATANA. A cylindrical slim tissue-equivalent proportional counter (TEPC) of 2.7 mm external diameter has been used to compare the radiation quality of two spread-out Bragg peaks (SOBP) at the CATANA proton beam. (authors)

  1. Sub 100 nm proton beam micromachining: theoretical calculations on resolution limits

    International Nuclear Information System (INIS)

    Kan, J.A. van; Sum, T.C.; Osipowicz, T.; Watt, F.

    2000-01-01

    Proton beam micromachining is a novel direct-write process for the production of three-dimensional (3D) microstructures. A focused beam of MeV protons is scanned in a pre-determined pattern over a suitable resist material (e.g. PMMA or SU-8) and the latent image formed is subsequently developed chemically. In this paper calculations on theoretical resolution limits of proton beam micromachined three-dimensional microstructures are presented. Neglecting the finite beam size, a Monte Carlo ion transport code was used in combination with a theoretical model describing the delta-ray (δ-ray) energy deposition to determine the lateral energy deposition distribution in PMMA resist material. The energy deposition distribution of ion induced secondary electrons (δ-rays) has been parameterized using analytical models. It is assumed that the attainable resolution is limited by a convolution of the spread of the ion beam and energy deposition of the δ-rays

  2. A high repetition rate transverse beam profile diagnostic for laser-plasma proton sources

    Science.gov (United States)

    Dover, Nicholas; Nishiuchi, Mamiko; Sakaki, Hironao; Kando, Masaki; Nishitani, Keita

    2016-10-01

    The recently upgraded J-KAREN-P laser can provide PW peak power and intensities approaching 1022 Wcm-2 at 0.1 Hz. Scaling of sheath acceleration to such high intensities predicts generation of protons to near 100 MeV, but changes in electron heating mechanisms may affect the emitted proton beam properties, such as divergence and pointing. High repetition rate simultaneous measurement of the transverse proton distribution and energy spectrum are therefore key to understanding and optimising the source. Recently plastic scintillators have been used to measure online proton beam transverse profiles, removing the need for time consuming post-processing. We are therefore developing a scintillator based transverse proton beam profile diagnostic for use in ion acceleration experiments using the J-KAREN-P laser. Differential filtering provides a coarse energy spectrum measurement, and time-gating allows differentiation of protons from other radiation. We will discuss the design and implementation of the diagnostic, as well as proof-of-principle results from initial experiments on the J-KAREN-P system demonstrating the measurement of sheath accelerated proton beams up to 20 MeV.

  3. Supine craniospinal irradiation in pediatric patients by proton pencil beam scanning.

    Science.gov (United States)

    Farace, Paolo; Bizzocchi, Nicola; Righetto, Roberto; Fellin, Francesco; Fracchiolla, Francesco; Lorentini, Stefano; Widesott, Lamberto; Algranati, Carlo; Rombi, Barbara; Vennarini, Sabina; Amichetti, Maurizio; Schwarz, Marco

    2017-04-01

    Proton therapy is the emerging treatment modality for craniospinal irradiation (CSI) in pediatric patients. Herein, special methods adopted for CSI at proton Therapy Center of Trento by pencil beam scanning (PBS) are comprehensively described. Twelve pediatric patients were treated by proton PBS using two/three isocenters. Special methods refer to: (i) patient positioning in supine position on immobilization devices crossed by the beams; (ii) planning field-junctions via the ancillary-beam technique; (iii) achieving lens-sparing by three-beams whole-brain-irradiation; (iv) applying a movable-snout and beam-splitting technique to reduce the lateral penumbra. Patient-specific quality assurance (QA) program was performed using two-dimensional ion chamber array and γ-analysis. Daily kilovoltage alignment was performed. PBS allowed to obtain optimal target coverage (mean D98%>98%) with reduced dose to organs-at-risk. Lens sparing was obtained (mean D1∼730cGyE). Reducing lateral penumbra decreased the dose to the kidneys (mean Dmean4cm (mean γ>95%) than at depths<4cm. The reported methods allowed to effectively perform proton PBS CSI. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. SU-E-T-577: Obliquity Factor and Surface Dose in Proton Beam Therapy

    International Nuclear Information System (INIS)

    Das, I; Andersen, A; Coutinho, L

    2015-01-01

    Purpose: The advantage of lower skin dose in proton beam may be diminished creating radiation related sequalae usually seen with photon and electron beams. This study evaluates the surface dose as a complex function of beam parameters but more importantly the effect of beam angle. Methods: Surface dose in proton beam depends on the beam energy, source to surface distance, the air gap between snout and surface, field size, material thickness in front of surface, atomic number of the medium, beam angle and type of nozzle (ie double scattering, (DS), uniform scanning (US) or pencil beam scanning (PBS). Obliquity factor (OF) is defined as ratio of surface dose in 0° to beam angle Θ. Measurements were made in water phantom at various beam angles using very small microdiamond that has shown favorable beam characteristics for high, medium and low proton energy. Depth dose measurements were performed in the central axis of the beam in each respective gantry angle. Results: It is observed that surface dose is energy dependent but more predominantly on the SOBP. It is found that as SSD increases, surface dose decreases. In general, SSD, and air gap has limited impact in clinical proton range. High energy has higher surface dose and so the beam angle. The OF rises with beam angle. Compared to OF of 1.0 at 0° beam angle, the value is 1.5, 1.6, 1,7 for small, medium and large range respectively for 60 degree angle. Conclusion: It is advised that just like range and SOBP, surface dose should be clearly understood and a method to reduce the surface dose should be employed. Obliquity factor is a critical parameter that should be accounted in proton beam therapy and a perpendicular beam should be used to reduce surface dose

  5. Changes in optical properties of polystyrene thin films by proton beam irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Sung Hyun; Jung, Jin Mook; Choi, Jae Hak [Dept. of of Polymer Science and Engineering, Chungnam National University, Daejeon (Korea, Republic of); Jung, Chan Hee; Hwang, In Tae; Shin, Jun Hwa [Research Division for Industry and Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup(Korea, Republic of)

    2017-06-15

    In this study, changes in optical properties of polystyrene (PS) thin films by proton irradiation were investigated. PS thin films were irradiated with 150 keV proton ions at fluences ranging from 1 × 10{sup 15} to 1 × 10{sup 16} ions cm{sup -2}. The chemical structures and optical properties of proton beam-irradiated PS thin films were investigated by using a FT-IR spectrometer, an UVvis spectrophotometer, a photoluminescence (PL) and a fluorescence microscope. The results of the chemical structure analysis revealed that chemical functional groups, such as OH, C=O, and C=C, were formed in the PS films due to the oxidation and formation of carbon clusters by proton beam irradiation. The PL emission was generated and gradually red-shifted with an increasing fluence due to the higher formation of sp2 carbon clusters by proton beam irradiation. The highest PL intensity was obtained at a fluence of 5×10{sup 15} ions cm{sup -2}. The optical band gap of PS calculated by using a Tauc’s plot decreased with increasing the fluence due to the formation of sp2 carbon clusters by proton beam irradiation.

  6. Poster - 25: Neutron Spectral Measurements around a Scanning Proton Beam

    Energy Technology Data Exchange (ETDEWEB)

    Kildea, John; Enger, Shirin; Maglieri, Robert; Mirzakhanian, Lalageh; Dahlgren, Christina Vallhagen; Dubeau, Jacques; Witharana, Sanjeeva [Medical Physics Unit, McGill University Health Centre, Medical Physics Unit, McGill University, Medical Physics Unit, McGill University, Medical Physics Unit, McGill University, Skandion Clinic, Detec Inc., Gatineau, Quebec, Detec Inc., Gatineau, Quebec (Canada)

    2016-08-15

    We describe the measurements of neutron spectra that we undertook around a scanning proton beam at the Skandion proton therapy clinic in Uppsala, Sweden. Measurements were undertaken using an extended energy range Nested Neutron Spectrometer (NNS, Detec Inc., Gatineau, QC) operated in pulsed and current mode. Spectra were measured as a function of location in the treatment room and for various Bragg peak depths. Our preliminary unfolded data clearly show the direct, evaporation and thermal neutron peaks and we can show the effect on the neutron spectrum of a water phantom in the primary proton beam.

  7. Quasi-monoenergetic proton beam produced by cone-top-end target

    International Nuclear Information System (INIS)

    Yu Jinqing; Jin Xiaolin; Li Bin; Zhou Weimin; Gu Yuqiu

    2012-01-01

    A scheme for generating quasi-monoenergetic proton beam is presented. In this paper, a new cone-top-end target is proposed and investigated by two-dimensional particle-in-cell (2D-PIC) simulation. The simulation results show that this target configuration can guide the hot electrons by the self-generated magnetic field along the profile of the cone-top-end target. The peak magnitude of sheath field at the rear surface of solid target can be enhanced, so the proton energy can be improved. The proton beam with energy spread of 9.9% can be obtained. (authors)

  8. Real-time beam monitoring in scanned proton therapy

    Science.gov (United States)

    Klimpki, G.; Eichin, M.; Bula, C.; Rechsteiner, U.; Psoroulas, S.; Weber, D. C.; Lomax, A.; Meer, D.

    2018-05-01

    When treating cancerous tissues with protons beams, many centers make use of a step-and-shoot irradiation technique, in which the beam is steered to discrete grid points in the tumor volume. For safety reasons, the irradiation is supervised by an independent monitoring system validating cyclically that the correct amount of protons has been delivered to the correct position in the patient. Whenever unacceptable inaccuracies are detected, the irradiation can be interrupted to reinforce a high degree of radiation protection. At the Paul Scherrer Institute, we plan to irradiate tumors continuously. By giving up the idea of discrete grid points, we aim to be faster and more flexible in the irradiation. But the increase in speed and dynamics necessitates a highly responsive monitoring system to guarantee the same level of patient safety as for conventional step-and-shoot irradiations. Hence, we developed and implemented real-time monitoring of the proton beam current and position. As such, we read out diagnostic devices with 100 kHz and compare their signals against safety tolerances in an FPGA. In this paper, we report on necessary software and firmware enhancements of our control system and test their functionality based on three exemplary error scenarios. We demonstrate successful implementation of real-time beam monitoring and, consequently, compliance with international patient safety regulations.

  9. Structural dynamic response of target container against proton beam

    International Nuclear Information System (INIS)

    Kikuchi, Kenji; Ishikura, Syuichi; Futakawa, Masatoshi; Hino, Ryutaro

    1997-01-01

    Stress waves were analyzed for a target container of neutron science research project using a high-intensity proton accelerator that generates high energy and high current proton beam. In the mercury target, the pulsed proton beam generates intense power density in the course of spallation reaction and causes pressure wave in the mercury and stress wave in the target container due to a sudden temperature change. Structural integrity of the target container depends on the power intensity at a maximum energy deposit. A broad proton profile is favorable to the structural assessment of the container rather than narrow one. Stress wave have propagated in the target container at a speed of sound. It only takes 0.1 ms for the size of 40 cm length stainless steel container. Further assessment is necessary to optimize a geometry of the container and establish a method to evaluate a life time. (author)

  10. Structural dynamic response of target container against proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Kikuchi, Kenji; Ishikura, Syuichi; Futakawa, Masatoshi; Hino, Ryutaro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-11-01

    Stress waves were analyzed for a target container of neutron science research project using a high-intensity proton accelerator that generates high energy and high current proton beam. In the mercury target, the pulsed proton beam generates intense power density in the course of spallation reaction and causes pressure wave in the mercury and stress wave in the target container due to a sudden temperature change. Structural integrity of the target container depends on the power intensity at a maximum energy deposit. A broad proton profile is favorable to the structural assessment of the container rather than narrow one. Stress wave have propagated in the target container at a speed of sound. It only takes 0.1 ms for the size of 40 cm length stainless steel container. Further assessment is necessary to optimize a geometry of the container and establish a method to evaluate a life time. (author)

  11. On a method for high-energy electron beam production in proton synchrotrons

    International Nuclear Information System (INIS)

    Bessonov, E.G.; Vazdik, Ya.A.

    1979-01-01

    It is suggested to produce high-energy electron beams in such a way that the ultrarelativistic protons give an amount of their kinetic energy to the electrons of a thin target, placed inside the working volume of the proton synchrotron. The kinematics of the elastic scattering of relativistic protons on electrons at rest is treated. Evaluation of a number of elastically-scattered electrons by 1000 GeV and 3000 GeV proton beams is presented. The method under consideration is of certain practical interest and may appear to be preferable in a definite energy range of protons and electrons

  12. The future and progress of proton beam radiotherapy

    International Nuclear Information System (INIS)

    Tsujii, Hirohiko

    1994-01-01

    The advantage of proton therapy is reduction of treatment volumes relative to those feasible with conventional photon therapy. The consequence is that the radiation dose to the target can be raised, with a resultant increase in tumor control probability. Proton beams, however, yield no biological gains because their biological properties are similar to conventional low LET radiations. As more sophisticated technologies are needed, there have been many advances which are applicable to photon therapy; 3-D treatment planning, DVH analysis, and systems for positioning, etc. As of January 1994, a total of about 13,000 cases were reported as having had treatments with proton beams in 16 centers world wide. The tumor sites for those include uveal melanoma (30-40%), intra-cranial small targets (40%), and others. Uveal melanomas had been most extensively treated with 70 Gy/5 fx or 60 Gy/4 fx which resulted in local control and survival rates of >96% and 80%, respectively. For chordoma and chondrosarcoma of the skull base and cervical spine, the 5 year local control rates were 65% and 91%, respectively. Promising results are also being obtained for head and neck and pelvic tumors. Deeper-seated tumors have been treated only at Tsukuba University with successful results in some anatomic sites. Among these, inoperable primary hepatocellular carcinomas were effectively treated with a total dose of 75-85 Gy (3.0-4.5 Gy/fx). The 3 year survival rates for all patients, Child A+B patient, and Child A patients were 38%, 47%, and 60%, respectively, which compare favorably to other modalities. These successful results of world wide proton therapy have led us to the conclusion that a hospital-based proton facility will provide opportunities for additional patients to be treated with protons. Thus, new plans are proposed from more than 10 institutions to build a new treatment center or upgrade the energy of currently available proton beams. (author)

  13. Relative and absolute dosimetry of proton therapy beams

    International Nuclear Information System (INIS)

    Mazal, A.; Delacroix, S.; Bridier, A.; Daures, J.; Dolo, J.M.; Nauraye, C.; Ferrand, R.; Cosgrave, V.; Habrand, J.L.

    1995-01-01

    Different codes of practice are in use or under preparation by several groups and national or international societies, concerning the dosimetry of proton beams. In spite of a large number of experiences and the increasing interest on this field, there are still large incertitudes on some of the basic conversion and correction factors to get dose values from different measuring methods. In practice, dose uniformity between centers is searched and encouraged by intercomparisons using standard procedures. We present the characteristics and the results on proton dosimetry intercomparisons using calorimeters, Faraday cups and ion chambers, as well as on the use of other detectors like diodes, radiographic films and TLD. New detectors like diamond, scintillators, radiochromic films, alanine, gels, ... can give new solutions to particular problems, provided their response is not affected at the end of the proton range (higher LET region), and their resolution, range, linearity, cost, ... are well adapted to practical situations. Some examples of special challenges are non interfering measurements during treatments for quality control, in vivo measurements, small beams for stereotactic irradiations, scanned beams and correlations between dosimetry, microdosimetry and radiobiology

  14. Proton beam shaped by “particle lens” formed by laser-driven hot electrons

    International Nuclear Information System (INIS)

    Zhai, S. H.; Shen, B. F.; Wang, W. P.; Zhang, H.; Zhang, L. G.; Huang, S.; Xu, Z. Z.; He, S. K.; Lu, F.; Zhang, F. Q.; Deng, Z. G.; Dong, K. G.; Wang, S. Y.; Zhou, K. N.; Xie, N.; Wang, X. D.; Liu, H. J.; Zhao, Z. Q.; Gu, Y. Q.; Zhang, B. H.

    2016-01-01

    Two-dimensional tailoring of a proton beam is realized by a “particle lens” in our experiment. A large quantity of electrons, generated by an intense femtosecond laser irradiating a polymer target, produces an electric field strong enough to change the trajectory and distribution of energetic protons flying through the electron area. The experiment shows that a strip pattern of the proton beam appears when hot electrons initially converge inside the plastic plate. Then the shape of the proton beam changes to a “fountain-like” pattern when these hot electrons diffuse after propagating a distance.

  15. Luminescence imaging of water during proton-beam irradiation for range estimation

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Seiichi, E-mail: s-yama@met.nagoya-u.ac.jp; Okumura, Satoshi; Komori, Masataka [Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673 (Japan); Toshito, Toshiyuki [Department of Proton Therapy Physics, Nagoya Proton Therapy Center, Nagoya City West Medical Center, Nagoya 462-8508 (Japan)

    2015-11-15

    Purpose: Proton therapy has the ability to selectively deliver a dose to the target tumor, so the dose distribution should be accurately measured by a precise and efficient method. The authors found that luminescence was emitted from water during proton irradiation and conjectured that this phenomenon could be used for estimating the dose distribution. Methods: To achieve more accurate dose distribution, the authors set water phantoms on a table with a spot scanning proton therapy system and measured the luminescence images of these phantoms with a high-sensitivity, cooled charge coupled device camera during proton-beam irradiation. The authors imaged the phantoms of pure water, fluorescein solution, and an acrylic block. Results: The luminescence images of water phantoms taken during proton-beam irradiation showed clear Bragg peaks, and the measured proton ranges from the images were almost the same as those obtained with an ionization chamber. Furthermore, the image of the pure-water phantom showed almost the same distribution as the tap-water phantom, indicating that the luminescence image was not related to impurities in the water. The luminescence image of the fluorescein solution had ∼3 times higher intensity than water, with the same proton range as that of water. The luminescence image of the acrylic phantom had a 14.5% shorter proton range than that of water; the proton range in the acrylic phantom generally matched the calculated value. The luminescence images of the tap-water phantom during proton irradiation could be obtained in less than 2 s. Conclusions: Luminescence imaging during proton-beam irradiation is promising as an effective method for range estimation in proton therapy.

  16. Luminescence imaging of water during proton-beam irradiation for range estimation

    International Nuclear Information System (INIS)

    Yamamoto, Seiichi; Okumura, Satoshi; Komori, Masataka; Toshito, Toshiyuki

    2015-01-01

    Purpose: Proton therapy has the ability to selectively deliver a dose to the target tumor, so the dose distribution should be accurately measured by a precise and efficient method. The authors found that luminescence was emitted from water during proton irradiation and conjectured that this phenomenon could be used for estimating the dose distribution. Methods: To achieve more accurate dose distribution, the authors set water phantoms on a table with a spot scanning proton therapy system and measured the luminescence images of these phantoms with a high-sensitivity, cooled charge coupled device camera during proton-beam irradiation. The authors imaged the phantoms of pure water, fluorescein solution, and an acrylic block. Results: The luminescence images of water phantoms taken during proton-beam irradiation showed clear Bragg peaks, and the measured proton ranges from the images were almost the same as those obtained with an ionization chamber. Furthermore, the image of the pure-water phantom showed almost the same distribution as the tap-water phantom, indicating that the luminescence image was not related to impurities in the water. The luminescence image of the fluorescein solution had ∼3 times higher intensity than water, with the same proton range as that of water. The luminescence image of the acrylic phantom had a 14.5% shorter proton range than that of water; the proton range in the acrylic phantom generally matched the calculated value. The luminescence images of the tap-water phantom during proton irradiation could be obtained in less than 2 s. Conclusions: Luminescence imaging during proton-beam irradiation is promising as an effective method for range estimation in proton therapy

  17. Structural design study of a proton beam window for a 1-MW spallation neutron source

    Energy Technology Data Exchange (ETDEWEB)

    Teraoku, Takuji; Terada, Atsuhiko; Maekawa, Fujio; Meigo, Shin-ichiro; Kaminaga, Masanori; Ishikura, Syuichi; Hino, Ryutaro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2003-03-01

    A 1-MW spallation neutron source aiming at materials and life science researches will be constructed under the JAERI-KEK High-intensity Proton Accelerator Project (J-PARC). A proton beam passes through a proton beam window, and be injected into a target of the neutron source. The proton beam window functions as a boundary wall between a high vacuum area in the proton beam line and a helium atmosphere at about atmospheric pressure in a helium vessel which contains the target and moderators. The proton beam window is cooled by light water because high heat-density is generated in the window material by interactions with the proton beam. Then, uniformity of the water flow is requested at the window to suppress a hot-spot that causes excessive thermal stress and cooling water boiling. Also, the window has to be strong enough in its structure for inner stress due to water pressure and thermal stress due to heat generation. In this report, we propose two types of proton beam windows; one flat-type that is easy to manufacture, and the other, curved-type that has high stress resistivity. As a part of design study for the windows, evaluation of strength of structure and thermal hydraulic analysis were conducted. As a result, it was found that sufficient heat removal was assured with uniform water flow at the window, and stress caused by internal water pressure and thermal stress could be maintained below allowable stress values. Accordingly, it was confirmed that the proton beam window designs were feasible. (author)

  18. Study on the proton-induced X-ray emission(PIXE) using external proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, M. Y.; Yoon, J. C.; Park, K. J. [Seoul Natioanl University, Seoul (Korea, Republic of)

    2008-04-15

    We intend to develop a system that can extract a proton beam into air for a qualitative, and quantitative PIXE analysis up to ppm(percent per million) composition. When such an R and D is accomplished, first it is possible to get equipped with a system for PIXE and PIGmE, second, it is possible to contribute to an academic progress by the study for physical properties of matter through an nuclear science methods when the comparison between the measurement and the calculated quantities, and third, it is possible to contribute to a multi-disciplinary researches by the measurements of the samples for which it is hard to get the SRM for the samples. We intend to develop methods to measure the beam current for an air-borne proton beam, and to minimize the energy and current loss of the beam. We intend to acquire a set of PIXE data for rare-earth metals and transient metals, to form a basic database for the analysis for various samples for which it is hard to get the SRM. Developed PIXE beamline can extract the beam diameter up to 5mm, and beam intensity in the range 0.5nA to 10nA variable. sustaining the vacuum better than 10{sup -6} mtorr. Necessary detection system and methodology are complete. As the application of the present research achievements, we studied the analysis of aerosol composition, the appraisal of the cultural heritages, and a feasibility study for a proton beam writing. It is expected to become possible to analyse the compositions of the gems, the elemental compositions of the food, the discrimination of the traditional ink and the modern ink on the documents, the evaluation of the documents by the analysis of the elemental composition of the stamps, The analysis of the paper with respect to the date and the quality, the analysis of the color, and the core bored samples

  19. Electron clearing for the ISA proton beam

    International Nuclear Information System (INIS)

    Herrera, J.C.

    1976-01-01

    The circulating protons in the ISABELLE intersecting storage ring accelerator will collide with the residual gas in the vacuum chamber. The electrons produced will tend to be captured by the potential well of the beam itself and result in a neutralization of the space charge of the beam. A detailed analysis is given of the various mechanisms which can be used to reduce the net degree of beam neutralization. It is concluded that the average neutralization will be about 10 -4 for a residual gas pressure of 3 x 10 -11 torr of hydrogen

  20. An analytical reconstruction model of the spread-out Bragg peak using laser-accelerated proton beams.

    Science.gov (United States)

    Tao, Li; Zhu, Kun; Zhu, Jungao; Xu, Xiaohan; Lin, Chen; Ma, Wenjun; Lu, Haiyang; Zhao, Yanying; Lu, Yuanrong; Chen, Jia-Er; Yan, Xueqing

    2017-07-07

    With the development of laser technology, laser-driven proton acceleration provides a new method for proton tumor therapy. However, it has not been applied in practice because of the wide and decreasing energy spectrum of laser-accelerated proton beams. In this paper, we propose an analytical model to reconstruct the spread-out Bragg peak (SOBP) using laser-accelerated proton beams. Firstly, we present a modified weighting formula for protons of different energies. Secondly, a theoretical model for the reconstruction of SOBPs with laser-accelerated proton beams has been built. It can quickly calculate the number of laser shots needed for each energy interval of the laser-accelerated protons. Finally, we show the 2D reconstruction results of SOBPs for laser-accelerated proton beams and the ideal situation. The final results show that our analytical model can give an SOBP reconstruction scheme that can be used for actual tumor therapy.

  1. Proton Radiography: Cross Section Measurements and Detector Development

    International Nuclear Information System (INIS)

    Longo, Michael J.

    2003-01-01

    OAK-B135 The physics goal of this project is to measure forward production of neutrons and photons produced by high-energy proton beams striking a variety of targets. This will provide data essential to proton radiography. This work is being carried out in conjunction with the Fermilab Experiment 907 (MIPP) collaboration including physicists from Lawrence Livermore Laboratory. Our group is responsible for the E907 forward neutron/photon calorimeter. The project is on track to meet its technical milestones, though the overall schedule at Fermilab has slipped. The electromagnetic calorimeter and the hadron calorimeter were both assembled and ready for testing with beam in December 2003

  2. SU-C-204-02: Behavioral and Pathologic Differences in Mice Exposed to Proton Minibeam Arrays Versus Proton Broad Beams

    International Nuclear Information System (INIS)

    Eley, J; Zhang, C; Wolfe, T; Vichaya, E; Quini, C; Chadha, A; Sahoo, N; Krishnan, S; Davis, J; Dilmanian, F

    2016-01-01

    Purpose: Minibeam therapy using protons or light-ions offers a theoretical reduction of biologic damage to tissues upstream of a tumor compared to broad-beam therapy while providing equal tumor control. The purpose of this study was to investigate behavioral and pathologic differences in mice after exposure of healthy brain to proton minibeam arrays versus proton broad beams. Methods: Twenty-four C57BL/6J juvenile mice were divided into 5 study arms: sham irradiation (NoRT), broad-beam 10 Gy (BB10), minibeam 10Gy (MB10), broad-beam 30 Gy (BB30), and minibeam 30 Gy (MB30), approximate integral entrance doses. Circular beams of 100 MeV protons with 7-mm diameter were delivered laterally through the brain, either as broad beams or as planar minibeam arrays having 300-micron beam width and 1-mm spacing on center. Mice were followed for 8 months using standard behavioral tests. Pathologic studies were carried out at 8 months after irradiation. Results: Peak entrance doses were 10.0, 23.8, 30.0, and 71.3 Gy for mice in BB10, MB10, BB30, and MB30, respectively. Despite the high single-fraction doses, no animals showed signs of radiation sickness or neurophysical impairment over the 8-month study duration. The Morris water maze alternate-starting-position trial showed significant evidence of better spatial learning for mice in MB10 versus BB10 (p=0.026), but other behavioral tests showed no significant differences. Glial fibrillary acidic protein stains showed gliosis in arms BB10, BB30, and MB30 but not in NoRT or MB10. A secondary finding was categorically higher epilation in broad-beam arms compared with their minibeam dose counterparts. Conclusion: Our findings indicate trends that, despite the higher peak doses, proton minibeam therapy can reduce radiation side effects in shallow tissue and brain compared to proton broadbeam therapy. As the behavioral findings were mixed, confirmation studies are needed with larger numbers of animals. AAPM Research Seed Funding Grant

  3. SU-C-204-02: Behavioral and Pathologic Differences in Mice Exposed to Proton Minibeam Arrays Versus Proton Broad Beams

    Energy Technology Data Exchange (ETDEWEB)

    Eley, J; Zhang, C [University of Maryland School of Medicine, Baltimore, MD (United States); Wolfe, T; Vichaya, E; Quini, C; Chadha, A; Sahoo, N; Krishnan, S [The University of Texas MD Anderson Cancer Center, Houston, TX (United States); Davis, J; Dilmanian, F [Stony Brook University Medical Center, Stony Brook, NY (United States)

    2016-06-15

    Purpose: Minibeam therapy using protons or light-ions offers a theoretical reduction of biologic damage to tissues upstream of a tumor compared to broad-beam therapy while providing equal tumor control. The purpose of this study was to investigate behavioral and pathologic differences in mice after exposure of healthy brain to proton minibeam arrays versus proton broad beams. Methods: Twenty-four C57BL/6J juvenile mice were divided into 5 study arms: sham irradiation (NoRT), broad-beam 10 Gy (BB10), minibeam 10Gy (MB10), broad-beam 30 Gy (BB30), and minibeam 30 Gy (MB30), approximate integral entrance doses. Circular beams of 100 MeV protons with 7-mm diameter were delivered laterally through the brain, either as broad beams or as planar minibeam arrays having 300-micron beam width and 1-mm spacing on center. Mice were followed for 8 months using standard behavioral tests. Pathologic studies were carried out at 8 months after irradiation. Results: Peak entrance doses were 10.0, 23.8, 30.0, and 71.3 Gy for mice in BB10, MB10, BB30, and MB30, respectively. Despite the high single-fraction doses, no animals showed signs of radiation sickness or neurophysical impairment over the 8-month study duration. The Morris water maze alternate-starting-position trial showed significant evidence of better spatial learning for mice in MB10 versus BB10 (p=0.026), but other behavioral tests showed no significant differences. Glial fibrillary acidic protein stains showed gliosis in arms BB10, BB30, and MB30 but not in NoRT or MB10. A secondary finding was categorically higher epilation in broad-beam arms compared with their minibeam dose counterparts. Conclusion: Our findings indicate trends that, despite the higher peak doses, proton minibeam therapy can reduce radiation side effects in shallow tissue and brain compared to proton broadbeam therapy. As the behavioral findings were mixed, confirmation studies are needed with larger numbers of animals. AAPM Research Seed Funding Grant.

  4. Proton-Beam Therapy for Olfactory Neuroblastoma

    International Nuclear Information System (INIS)

    Nishimura, Hideki; Ogino, Takashi; Kawashima, Mitsuhiko; Nihei, Keiji; Arahira, Satoko; Onozawa, Masakatsu; Katsuta, Shoichi; Nishio, Teiji

    2007-01-01

    Purpose: To analyze the feasibility and efficacy of proton-beam therapy (PBT) for olfactory neuroblastoma (ONB) as a definitive treatment, by reviewing our preliminary experience. Olfactory neuroblastoma is a rare disease, and a standard treatment strategy has not been established. Radiation therapy for ONB is challenging because of the proximity of ONBs to critical organs. Proton-beam therapy can provide better dose distribution compared with X-ray irradiation because of its physical characteristics, and is deemed to be a feasible treatment modality. Methods and Materials: A retrospective review was performed on 14 patients who underwent PBT for ONB as definitive treatment at the National Cancer Center Hospital East (Kashiwa, Chiba, Japan) from November 1999 to February 2005. A total dose of PBT was 65 cobalt Gray equivalents (Gy E ), with 2.5-Gy E once-daily fractionations. Results: The median follow-up period for surviving patients was 40 months. One patient died from disseminated disease. There were two persistent diseases, one of which was successfully salvaged with surgery. The 5-year overall survival rate was 93%, the 5-year local progression-free survival rate was 84%, and the 5-year relapse-free survival rate was 71%. Liquorrhea was observed in one patient with Kadish's stage C disease (widely destroying the skull base). Most patients experienced Grade 1 to 2 dermatitis in the acute phase. No other adverse events of Grade 3 or greater were observed according to the RTOG/EORTC acute and late morbidity scoring system. Conclusions: Our preliminary results of PBT for ONB achieved excellent local control and survival outcomes without serious adverse effects. Proton-beam therapy is considered a safe and effective modality that warrants further study

  5. Relative biological effectiveness of the therapeutic proton beams at NIRS and Tsukuba University

    International Nuclear Information System (INIS)

    Ando, Koichi; Koike, Sachiko; Kawachi, Kiyomitsu

    1985-01-01

    Relative biological effectiveness (RBE) of proton beams dedicated to radiotherapy was examined using a method of simultaneous irradiation. Mice received i.v. transplantation of syngeneic fibrosarcoma (NFSa) cells. These mice were divided into 3 groups on the following day, and thorax was simultaneously irradiated with one of the following beams: 70MeV proton beam at National Institute of Radiological Sciences (NIRS), 250 MeV Proton beam at Tsukuba University (PARMS) and 60 Co γ ray. Ten to 13 days thereafter, lungs were removed for colony counts to give dose-cell survival relationships. RBE of NIRS proton was ranging from 1.01 to 1.12 with an average of 1.06 while that of PARMS proton was ranging from 1.03 to 1.09 with an average of 1.06 at surviving fraction of 0.01. The simultaneous irradiation for RBE study was found to be reliable at large dose-low survival regions. (author)

  6. Microdosimetric Characteristics of the Clinical Proton Beams at the JINR Phasotron, Dubna

    CERN Document Server

    Vlcek, B; Spurny, F

    2002-01-01

    The contribution of the high LET particles to dosimetric and microdosimetric characteristics of 150 and 205 MeV clinical proton beams was experimentally studied using track etched detectors. Secondary heavy charged particles produced from nuclear interactions and degraded protons at the Bragg peak region are particles with high LET. The method of the LET spectra measurement with track etched detectors allows one to determine the contribution of high LET particles to dosimetric characteristics of clinical proton beams: absorbed dose, equivalent dose and the value of the Relative Biological Effectiveness (RBE). Track detectors were irradiated in the various depth of clinical proton beams with the primary energies of 150 and 205 MeV. The LET spectra between 10 and 700 keV/m were measured by means of CR-39 track etched detectors and the automatic optical image analyzer LUCIA-II. The relative contribution of the high LET particles to absorbed dose increases from several per cent at the beam entrance to several ten...

  7. Analysis of protein content in grain by proton activation

    International Nuclear Information System (INIS)

    Dohan, D.A.; Standing, K.G.

    1976-01-01

    The total protein content of grain is an important measure of its nutritional value. More than one million protein analyses are carried out each year in Canada alone. The traditional method of measurement has been the Kjeldahl chemical technique, which measures total nitrogen. A new method of protein analysis which also measures total nitrogen has been developed. A beam of 16 MeV protons strikes a sample of grain and produces radioactive 14 0 nuclei through the reaction 14 N(p,n) 14 0. The effective sample thickness is determined by the proton range. The 14 0 decay (tausub(1/2)=71sec) is detected off-line by its characteristic 2.31 MeV γ-ray. The total number of protons hitting the sample is measured by integrating the beam current. The ratio of the number of γ-rays counted to the total number of protons striking the sample determines the abundance of nitrogen. The measurement is unambiguous, since no other reaction can produce 14 0 at 16 MeV proton energy. A mechanized system for sample handling has been constructed. Samples are carried into the irradiation area on a conveyor belt, then back through a shielding wall into a counting area. The laboratory PDP 15/40 computer controls the entire operation. At present the system is being tested at a rate of about two samples per minute. (author)

  8. Analyzing power in inclusive. pi. sup + and. pi. sup - production at high x sub F with a 200 GeV polarized proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Adams, D L; Bonner, B E; Buchanan, J A; Clement, J M; Corcoran, M D; Cranshaw, J; Nessi-Tedaldi, F; Nessi, M; Nguyen, C; Phillips, G C; Roberts, J B; Skeens, J; White, J L [T.W. Bonner Nuclear Lab., Rice Univ., Houston, TX (United States); Akchurin, N; Langland, J; Onel, Y [Dept. of Physics, Univ. of Iowa, Iowa City, IA (United States); Belikov, N I; Derevschikov, A A; Grachov, O A; Matulenko, Yu A; Meschanin, A P; Nurushev, S B; Patalakha, D I; Rykov, V L; Solovyanov, V L; Vasiliev, A N [Inst. of High Energy Physics, Serpukhov (USSR); Bystricky, J; Lehar, F; Lesquen, A de [CEN-Saclay, 91 - Gif-sur-Yvette (France); Cossairt, J D; Read, A L [Fermi National Accelerator Lab., Batavia, IL (United States); En' yo, H; Funahashi, H; Goto, Y; Imai, K; Itow, Y; Makino, S; Masaike, A; Miyake, K; Nagamine, T; Saito, N; Yamashita, S [Dept. of Physics, Kyoto Univ. (Japan); Grosnick, D P; Hill, D A; Lopiano, D; Ohashi, Y; Spinka, H; Stanek, R; FNAL E704 Collaboration

    1991-08-01

    The analyzing power in inclusive charged pion production has been measured using the 200 GeV Fermilab polarized proton beam. A striking dependence in {chi}{sub F} is observed in which A{sub N} increases from 0 to 0.42 with increasing {chi}{sub F} for the {pi}{sup +} data and decreases from 0 to -0.38 with increasing {chi}{sub F} for {pi}{sup -} data. The kinematic range covered is 0.2{<=}{chi}{sub F}{<=}0.9 and 0.2{<=}p{sub T}{<=}2.0 GeV/c. In a simple model our data indicate that at large {chi}{sub F} the transverse spin of the proton is correlated with that of its quark constituents. (orig.).

  9. The study of PDMS surface treatment and it's applications by using proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Baek, J. Y.; Kim, J. Y.; Kwon, K. H.; Park, J. Y. [Korea Univ., Seoul (Korea, Republic of)

    2007-04-15

    PDMS(Polydimethylsiloxane) is mainly used as a material to do lab on a chip for biochemical analysis. PDMS has many applicability at the Bio-Technology(BT) field, because it is flexible, biocompatible and has good oxygen permeability. In this study, we have investigated to physical and chemical changes of PDMS surface by proton beam radiation conditions. The used kind of ion were Ar and N, beam energy was 30keV, 60keV, 80keV, total fluence was 1E10 to 1E16 [ions/cm{sup 2}]. PDMS membrane was produced as 150 {mu}m thick on the 3' silicon wafer. We inquired into physical and chemical changes up to beam radiation conditions through the investigate the change of surface roughness by AFM(Atomic Force Microscope), the change of surface morphology by SEM(Scanning Electron Microscope) and the change of chemical composition by FT-IR(Fourier Transform Infrared Raman spectroscopy) and XPS(X-ray Photoelectron Spectroscopy). From these basic data to we set up the proton beam radiation conditions to secure metal layer and PDMS adhesion. This enables to produce the electrode at the PDMS material lab on a chip. From now on, we'll investigate the cell patterning possibility after carry out of cell culture with mouse fibroblast at PDMS surface what is surface modification by using of proton beam radiation and apply this to produce lab on a chip. Physical property: Surface roughness of PDMS membrane was observed using AFM, after exposure of proton beam on it. The roughness increased as the power level of proton beam increase. This phenomena was caused by the kinetic energy of particle. Chemical property: Long term observation was conducted on the contact angles of the samples made by the proton beam exposure or oxygen plasma treatment; the hydrophilicity was found to be stronger in the samples made by the proton beam exposure. We found the reason of this was the destruction of polymer chains by proton beam. Feasibility of Through-hole: Considering that comparatively high

  10. The role of a microDiamond detector in the dosimetry of proton pencil beams

    Energy Technology Data Exchange (ETDEWEB)

    Goma, Carles [Paul Scherrer Institute, Villigen (Switzerland). Centre for Proton Therapy; Swiss Federal Institute of Technology Zurich (Switzerland). Dept. of Physics; Marinelli, Marco; Verona-Rinati, Gianluca [Roma Univ. ' ' Tor Vergata' ' (Italy). Dipt. di Ingegneria Industriale; INFN, Roma (Italy); Safai, Sairos [Paul Scherrer Institute, Villigen (Switzerland). Centre for Proton Therapy; Wuerfel, Jan [PTW-Freiburg, Freiburg (Germany)

    2016-05-01

    In this work, the performance of a microDiamond detector in a scanned proton beam is studied and its potential role in the dosimetric characterization of proton pencil beams is assessed. The linearity of the detector response with the absorbed dose and the dependence on the dose-rate were tested. The depth-dose curve and the lateral dose profiles of a proton pencil beam were measured and compared to reference data. The feasibility of calibrating the beam monitor chamber with a microDiamond detector was also studied. It was found the detector reading is linear with the absorbed dose to water (down to few cGy) and the detector response is independent of both the dose-rate (up to few Gy/s) and the proton beam energy (within the whole clinically-relevant energy range). The detector showed a good performance in depth-dose curve and lateral dose profile measurements; and it might even be used to calibrate the beam monitor chambers-provided it is cross-calibrated against a reference ionization chamber. In conclusion, the microDiamond detector was proved capable of performing an accurate dosimetric characterization of proton pencil beams.

  11. Control of proton beam divergence in intense-laser foil-plasma interaction

    International Nuclear Information System (INIS)

    Kawata, S.; Sonobe, R.; Miyazaki, S.; Sakai, K.; Kikuchi, T.

    2006-01-01

    Quality of an ion beam is one of the critical factors in intense-laser ion beam generation. A purpose of this study is the suppression of transverse proton divergence by a controlled electron cloud in laser-foil interactions. In this study, the foil target has a hole at the opposite side of the laser illumination. The electrons accelerated by an intense laser are limited in transverse by a neutral plasma at a protuberant part. Therefore the protons are accelerated and also controlled transversely by the electron cloud structure. In our 2.5-dimensional Particle-in-Cell simulations we demonstrate that the transverse shape of the electron cloud is well controlled and the collimated proton beam is generated successfully in the target with the hole. (authors)

  12. Study of the Clinical Proton Beam Relative Biological Effectiveness at the JINR Phasotron, Dubna

    CERN Document Server

    Vitanova, A; Gaevskii, V N; Molokonov, A G; Spurny, F; Fadeeva, T A; Shmakova, N L

    2002-01-01

    Proton clinical beams contain particles with high linear energy transfer (LET). Secondary heavy charged particles produced from nuclear interactions and degraded protons at the Bragg peak region are particles with high LET. These particles could enhance the Relative Biological Effectiveness (RBE) of the proton beam. We have carried out two radiobiological experiments to investigate the RBE of 150 MeV clinical proton beam. The irradiation of the Chinese Hamster V79 cells were performed at two points of the depth-dose distribution - at the beam entrance and at the Bragg peak. The contribution of the high LET particles to dosimetric and microdosimetric characteristics in the various depth of proton beam was also experimentally studied using the CR-39 track etched detectors. The LET spectra between 10 and 700 keV/{\\mu}m were measured by means of track detectors and the automatic optical image analyzer LUCIA-II. The relative contribution of the high LET particles to ab! sorbed dose increases from several per cent ...

  13. Advanced applications in microphotonics using proton beam writing

    International Nuclear Information System (INIS)

    Bettiol, A.A.; Chiam, S.Y.; Teo, E.J.; Udalagama, C.; Chan, S.F.; Hoi, S.K.; Kan, J.A. van; Breese, M.B.H.; Watt, F.

    2009-01-01

    Proton beam writing (PBW) is a powerful tool for prototyping microphotonic structures in a wide variety of materials including polymers, insulators, semiconductors and metals. Prototyping is achieved either through direct fabrication with the proton beam, or by the fabrication of a master that can be used for replication. In recent times we have explored the use of PBW for various advanced optical applications including fabrication of subwavelength metallic structures and metamaterials, direct write of silicon waveguides for mid IR applications and integrated waveguides for lab-on-a-chip devices. This paper will review the recent progress made in these areas with particular emphasis on the main advantages of using the PBW technique for these novel applications.

  14. Influence of micromachined targets on laser accelerated proton beam profiles

    Science.gov (United States)

    Dalui, Malay; Permogorov, Alexander; Pahl, Hannes; Persson, Anders; Wahlström, Claes-Göran

    2018-03-01

    High intensity laser-driven proton acceleration from micromachined targets is studied experimentally in the target-normal-sheath-acceleration regime. Conical pits are created on the front surface of flat aluminium foils of initial thickness 12.5 and 3 μm using series of low energy pulses (0.5-2.5 μJ). Proton acceleration from such micromachined targets is compared with flat foils of equivalent thickness at a laser intensity of 7 × 1019 W cm-2. The maximum proton energy obtained from targets machined from 12.5 μm thick foils is found to be slightly lower than that of flat foils of equivalent remaining thickness, and the angular divergence of the proton beam is observed to increase as the depth of the pit approaches the foil thickness. Targets machined from 3 μm thick foils, on the other hand, show evidence of increasing the maximum proton energy when the depths of the structures are small. Furthermore, shallow pits on 3 μm thick foils are found to be efficient in reducing the proton beam divergence by a factor of up to three compared to that obtained from flat foils, while maintaining the maximum proton energy.

  15. Fabrication and optimization of a fiber-optic radiation sensor for proton beam dosimetry

    International Nuclear Information System (INIS)

    Jang, K.W.; Yoo, W.J.; Seo, J.K.; Heo, J.Y.; Moon, J.; Park, J.-Y.; Hwang, E.J.; Shin, D.; Park, S.-Y.; Cho, H.-S.; Lee, B.

    2011-01-01

    In this study, we fabricated a fiber-optic radiation sensor for proton therapy dosimetry and measured the output and the peak-to-plateau ratio of scintillation light with various kinds of organic scintillators in order to select an organic scintillator appropriate for measuring the dose of a proton beam. For the optimization of an organic scintillator, the linearity between the light output and the stopping power of a proton beam was evaluated for two different diameters of the scintillator, and the angular dependency and standard deviation of the light pulses were investigated for four different scintillator lengths. We also evaluated the linearity between the light output and the dose rate and monitor units of a proton generator, respectively. The relative depth-dose curve of the proton beam was obtained and corrected using Birk's theory.

  16. Experimental control of the beam properties of laser-accelerated protons and carbon ions

    Energy Technology Data Exchange (ETDEWEB)

    Amin, Munib

    2008-12-15

    The laser generation of energetic high quality beams of protons and heavier ions has opened up the door to a plethora of applications. These beams are usually generated by the interaction of a short pulse high power laser with a thin metal foil target. They could already be applied to probe transient phenomena in plasmas and to produce warm dense matter by isochoric heating. Other applications such as the production of radioisotopes and tumour radiotherapy need further research to be put into practice. To meet the requirements of each application, the properties of the laser-accelerated particle beams have to be controlled precisely. In this thesis, experimental means to control the beam properties of laser-accelerated protons and carbon ions are investigated. The production and control of proton and carbon ion beams is studied using advanced ion source designs: Experiments concerning mass-limited (i.e. small and isolated) targets are conducted. These targets have the potential to increase both the number and the energy of laser-accelerated protons. Therefore, the influence of the size of a plane foil target on proton beam properties is measured. Furthermore, carbon ion sources are investigated. Carbon ions are of particular interest in the production of warm dense matter and in cancer radiotherapy. The possibility to focus carbon ion beams is investigated and a simple method for the production of quasi-monoenergetic carbon ion beams is presented. This thesis also provides an insight into the physical processes connected to the production and the control of laser-accelerated ions. For this purpose, laser-accelerated protons are employed to probe plasma phenomena on laser-irradiated targets. Electric fields evolving on the surface of laser-irradiated metal foils and hollow metal foil cylinders are investigated. Since these fields can be used to displace, collimate or focus proton beams, understanding their temporal and spatial evolution is crucial for the design of

  17. Experimental control of the beam properties of laser-accelerated protons and carbon ions

    International Nuclear Information System (INIS)

    Amin, Munib

    2008-12-01

    The laser generation of energetic high quality beams of protons and heavier ions has opened up the door to a plethora of applications. These beams are usually generated by the interaction of a short pulse high power laser with a thin metal foil target. They could already be applied to probe transient phenomena in plasmas and to produce warm dense matter by isochoric heating. Other applications such as the production of radioisotopes and tumour radiotherapy need further research to be put into practice. To meet the requirements of each application, the properties of the laser-accelerated particle beams have to be controlled precisely. In this thesis, experimental means to control the beam properties of laser-accelerated protons and carbon ions are investigated. The production and control of proton and carbon ion beams is studied using advanced ion source designs: Experiments concerning mass-limited (i.e. small and isolated) targets are conducted. These targets have the potential to increase both the number and the energy of laser-accelerated protons. Therefore, the influence of the size of a plane foil target on proton beam properties is measured. Furthermore, carbon ion sources are investigated. Carbon ions are of particular interest in the production of warm dense matter and in cancer radiotherapy. The possibility to focus carbon ion beams is investigated and a simple method for the production of quasi-monoenergetic carbon ion beams is presented. This thesis also provides an insight into the physical processes connected to the production and the control of laser-accelerated ions. For this purpose, laser-accelerated protons are employed to probe plasma phenomena on laser-irradiated targets. Electric fields evolving on the surface of laser-irradiated metal foils and hollow metal foil cylinders are investigated. Since these fields can be used to displace, collimate or focus proton beams, understanding their temporal and spatial evolution is crucial for the design of

  18. Mutant breeding of ornamental trees for creating variations with high value using proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Yim, Jae Hong; Woo, Seong Min; Hwang, Mun Joo; Pyo, Sun Hui [Phygen, Daejeon (Korea, Republic of); Kwon, Hye Jin [Environmental-Friendly Agriculture Research Institute, Seoul (Korea, Republic of); Woo, Jong Suk [Cheonan Yonam College, Cheonan (Korea, Republic of)

    2010-04-15

    This research was conducted to investigate the proton-beam radiation sensitivity and seed germination rate of 18 ornamental plants and to survey the quantitative characteristics of proton beam induced strains. To induce the variants of ornamental plants, seeds were irradiated at the dose of 0{approx} 2kGy of proton beam at room temperature by 45 MeV MC-50 Cyclotron. After irradiation, to assess the effects of proton beam on radiation sensitivity and morphological changes of the plants and the seed germination rate were analysed. The effects of mutation induction by proton beam irradiation on seeds in Lagerstroemia indica and Ligustrum obtusifolium were investigated. Irradiation with proton beam at the dose of 750Gy induced mutants in leaf length, leaf width, internode length, plant height, leaf color, autumn leaves and plant width in each strains. According to a principal component analysis, the induced strains were divided into three groups. Promising strain(strain 25) for commercial varieties was selected Lagerstroemia indica. It was analysed that strain 25 showed the highest genetic dissimility from original species. The strain 25 had red leaf edge and maintained autumnal tints till late fall. So, we try to promote a patent registration of the strain 25 as a new caltivar 'Bulkkot'

  19. Mutant breeding of ornamental trees for creating variations with high value using proton beam

    International Nuclear Information System (INIS)

    Yim, Jae Hong; Woo, Seong Min; Hwang, Mun Joo; Pyo, Sun Hui; Kwon, Hye Jin; Woo, Jong Suk

    2010-04-01

    This research was conducted to investigate the proton-beam radiation sensitivity and seed germination rate of 18 ornamental plants and to survey the quantitative characteristics of proton beam induced strains. To induce the variants of ornamental plants, seeds were irradiated at the dose of 0∼ 2kGy of proton beam at room temperature by 45 MeV MC-50 Cyclotron. After irradiation, to assess the effects of proton beam on radiation sensitivity and morphological changes of the plants and the seed germination rate were analysed. The effects of mutation induction by proton beam irradiation on seeds in Lagerstroemia indica and Ligustrum obtusifolium were investigated. Irradiation with proton beam at the dose of 750Gy induced mutants in leaf length, leaf width, internode length, plant height, leaf color, autumn leaves and plant width in each strains. According to a principal component analysis, the induced strains were divided into three groups. Promising strain(strain 25) for commercial varieties was selected Lagerstroemia indica. It was analysed that strain 25 showed the highest genetic dissimility from original species. The strain 25 had red leaf edge and maintained autumnal tints till late fall. So, we try to promote a patent registration of the strain 25 as a new caltivar 'Bulkkot'

  20. Comparison of surface doses from spot scanning and passively scattered proton therapy beams

    International Nuclear Information System (INIS)

    Arjomandy, Bijan; Sahoo, Narayan; Gillin, Michael; Cox, James; Lee, Andrew

    2009-01-01

    Proton therapy for the treatment of cancer is delivered using either passively scattered or scanning beams. Each technique delivers a different amount of dose to the skin, because of the specific feature of their delivery system. The amount of dose delivered to the skin can play an important role in choosing the delivery technique for a specific site. To assess the differences in skin doses, we measured the surface doses associated with these two techniques. For the purpose of this investigation, the surface doses in a phantom were measured for ten prostate treatment fields planned with passively scattered proton beams and ten patients planned with spot scanning proton beams. The measured doses were compared to evaluate the differences in the amount of skin dose delivered by using these techniques. The results indicate that, on average, the patients treated with spot scanning proton beams received lower skin doses by an amount of 11.8% ± 0.3% than did the patients treated with passively scattered proton beams. That difference could amount to 4 CGE per field for a prescribed dose of 76 CGE in 38 fractions treated with two equally weighted parallel opposed fields. (note)

  1. SU-F-T-137: Out-Of-Beam Dose for a Compact Double-Scattering Proton Beam Therapy System

    Energy Technology Data Exchange (ETDEWEB)

    Islam, M; Ahmad, S; Jin, H [University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States)

    2016-06-15

    Purpose: The out-of-beam dose is important for understanding the peripheral dose in radiation therapy. In proton radiotherapy, the study of out-of-beam dose is scarce and the treatment planning system (TPS) based on pencil beam algorithm cannot accurately predict the out-of-beam dose. This study investigates the out-of-beam dose for the single-room Mevion S250 double scattering proton therapy system using experimentally measured and treatment planning software generated data. The results are compared with those reported for conventional photon beam therapy. However, this study does not incorporate the neutron contribution in the scattered dose. Methods: A total of seven proton treatment plans were generated using Varian Eclipse TPS for three different sites (brain, lung, and pelvis) in an anthropomorphic phantom. Three field sizes of 5×5, 10×10, and 20×20 cm{sup 2} (lung only) with typical clinical range (13.3–22.8 g/cm{sup 2}) and modulation widths (5.3–14.0 g/cm{sup 2}) were used. A single beam was employed in each treatment plan to deliver a dose of 181.8 cGy (200.0 cGy (RBE)) to the selected target. The out-of-beam dose was measured at 2.0, 5.0, 10.0, and 15.0 cm from the beam edge in the phantom using a thimble chamber (PTW TN31010). Results: The out-of-beam dose generally increased with field size, range, and volume irradiated. For all the plans, the scattered dose sharply fell off with distance. At 2.0 cm, the out-of-beam dose ranged from 0.35% to 2.16% of the delivered dose; however, the dose was clinically negligible (<0.3%) at a distance of 5.0 cm and greater. In photon therapy, the slightly greater out-of-beam dose was reported (TG36; 4%, 2%, and 1% for 2.0, 5.0, and 10.0 cm, respectively, using 6 MV beam). Conclusion: The measured out-of-beam dose in proton therapy excluding neutron contribution was observed higher than the TPS calculated dose and comparable to that of photon beam therapy.

  2. Radiographic film dosimetry of proton beams for depth‐dose constancy check and beam profile measurement

    Science.gov (United States)

    Teran, Anthony; Ghebremedhin, Abiel; Johnson, Matt; Patyal, Baldev

    2015-01-01

    Radiographic film dosimetry suffers from its energy dependence in proton dosimetry. This study sought to develop a method of measuring proton beams by the film and to evaluate film response to proton beams for the constancy check of depth dose (DD). It also evaluated the film for profile measurements. To achieve this goal, from DDs measured by film and ion chamber (IC), calibration factors (ratios of dose measured by IC to film responses) as a function of depth in a phantom were obtained. These factors imply variable slopes (with proton energy and depth) of linear characteristic curves that relate film response to dose. We derived a calibration method that enables utilization of the factors for acquisition of dose from film density measured at later dates by adapting to a potentially altered processor condition. To test this model, the characteristic curve was obtained by using EDR2 film and in‐phantom film dosimetry in parallel with a 149.65 MeV proton beam, using the method. An additional validation of the model was performed by concurrent film and IC measurement perpendicular to the beam at various depths. Beam profile measurements by the film were also evaluated at the center of beam modulation. In order to interpret and ascertain the film dosimetry, Monte Carlos simulation of the beam was performed, calculating the proton fluence spectrum along depths and off‐axis distances. By multiplying respective stopping powers to the spectrum, doses to film and water were calculated. The ratio of film dose to water dose was evaluated. Results are as follows. The characteristic curve proved the assumed linearity. The measured DD approached that of IC, but near the end of the spread‐out Bragg peak (SOBP), a spurious peak was observed due to the mismatch of distal edge between the calibration and measurement films. The width of SOBP and the proximal edge were both reproducible within a maximum of 5 mm; the distal edge was reproducible within 1 mm. At 5 cm depth, the

  3. Experimental support at proton--proton colliding beam facilities

    International Nuclear Information System (INIS)

    Potter, K.

    1977-01-01

    Proton--proton colliding beam facilities have a number of special features which increase the importance of support for experiments when compared to fixed target accelerators: (1) the laboratory system is very close to the center-of-mass system; this affects the geometry and general size of the experiments; (2) the primary p--p interaction is inaccessible, that is, it takes place in an ultrahigh vacuum chamber; and (3) the experiment detection system is necessarily inside the machine structure and becomes very closely linked to it in many respects. An overall picture is given of experimental support based on experience at the CERN ISR under the following headings: Experimental Areas, Scheduling, Intersection Vacuum Chambers, Machine Background, and Magnets for Experiments. The first two of these topics concern the requirements in space and time of an experiment, while the last three are all related to the close interaction between experiment and machine

  4. Impact of high energy high intensity proton beams on targets: Case studies for Super Proton Synchrotron and Large Hadron Collider

    Directory of Open Access Journals (Sweden)

    N. A. Tahir

    2012-05-01

    Full Text Available The Large Hadron Collider (LHC is designed to collide two proton beams with unprecedented particle energy of 7 TeV. Each beam comprises 2808 bunches and the separation between two neighboring bunches is 25 ns. The energy stored in each beam is 362 MJ, sufficient to melt 500 kg copper. Safety of operation is very important when working with such powerful beams. An accidental release of even a very small fraction of the beam energy can result in severe damage to the equipment. The machine protection system is essential to handle all types of possible accidental hazards; however, it is important to know about possible consequences of failures. One of the critical failure scenarios is when the entire beam is lost at a single point. In this paper we present detailed numerical simulations of the full impact of one LHC beam on a cylindrical solid carbon target. First, the energy deposition by the protons is calculated with the FLUKA code and this energy deposition is used in the BIG2 code to study the corresponding thermodynamic and the hydrodynamic response of the target that leads to a reduction in the density. The modified density distribution is used in FLUKA to calculate new energy loss distribution and the two codes are thus run iteratively. A suitable iteration step is considered to be the time interval during which the target density along the axis decreases by 15%–20%. Our simulations suggest that the full LHC proton beam penetrates up to 25 m in solid carbon whereas the range of the shower from a single proton in solid carbon is just about 3 m (hydrodynamic tunneling effect. It is planned to perform experiments at the experimental facility HiRadMat (High Radiation Materials at CERN using the proton beam from the Super Proton Synchrotron (SPS, to compare experimental results with the theoretical predictions. Therefore simulations of the response of a solid copper cylindrical target hit by the SPS beam were performed. The particle

  5. Impact of high energy high intensity proton beams on targets: Case studies for Super Proton Synchrotron and Large Hadron Collider

    Science.gov (United States)

    Tahir, N. A.; Sancho, J. Blanco; Shutov, A.; Schmidt, R.; Piriz, A. R.

    2012-05-01

    The Large Hadron Collider (LHC) is designed to collide two proton beams with unprecedented particle energy of 7 TeV. Each beam comprises 2808 bunches and the separation between two neighboring bunches is 25 ns. The energy stored in each beam is 362 MJ, sufficient to melt 500 kg copper. Safety of operation is very important when working with such powerful beams. An accidental release of even a very small fraction of the beam energy can result in severe damage to the equipment. The machine protection system is essential to handle all types of possible accidental hazards; however, it is important to know about possible consequences of failures. One of the critical failure scenarios is when the entire beam is lost at a single point. In this paper we present detailed numerical simulations of the full impact of one LHC beam on a cylindrical solid carbon target. First, the energy deposition by the protons is calculated with the FLUKA code and this energy deposition is used in the BIG2 code to study the corresponding thermodynamic and the hydrodynamic response of the target that leads to a reduction in the density. The modified density distribution is used in FLUKA to calculate new energy loss distribution and the two codes are thus run iteratively. A suitable iteration step is considered to be the time interval during which the target density along the axis decreases by 15%-20%. Our simulations suggest that the full LHC proton beam penetrates up to 25 m in solid carbon whereas the range of the shower from a single proton in solid carbon is just about 3 m (hydrodynamic tunneling effect). It is planned to perform experiments at the experimental facility HiRadMat (High Radiation Materials) at CERN using the proton beam from the Super Proton Synchrotron (SPS), to compare experimental results with the theoretical predictions. Therefore simulations of the response of a solid copper cylindrical target hit by the SPS beam were performed. The particle energy in the SPS beam is 440

  6. SU-E-T-470: Beam Performance of the Radiance 330 Proton Therapy System

    International Nuclear Information System (INIS)

    Nazaryan, H; Nazaryan, V; Wang, F; Flanz, J; Alexandrov, V

    2014-01-01

    Purpose: The ProTom Radiance 330 proton radiotherapy system is a fully functional, compact proton radiotherapy system that provides advanced proton delivery capabilities. It supports three-dimensional beam scanning with energy and intensity modulation. A series of measurements have been conducted to characterize the beam performance of the first installation of the system at the McLaren Proton Therapy Center in Flint, Michigan. These measurements were part of the technical commissioning of the system. Select measurements and results are presented. Methods: The Radiance 330 proton beam energy range is 70–250 MeV for treatment, and up to 330 MeV for proton tomography and radiography. Its 3-D scanning capability, together with a small beam emittance and momentum spread, provides a highly efficient beam delivery. During the technical commissioning, treatment plans were created to deliver uniform maps at various energies to perform Gamma Index analysis. EBT3 Gafchromic films were irradiated using the Planned irradiation maps. Bragg Peak chamber was used to test the dynamic range during a scan in one layer for high (250 MeV) and Low (70 MeV) energies. The maximum and minimum range, range adjustment and modulation, distal dose falloff (80%–20%), pencil beam spot size, spot placement accuracy were also measured. The accuracy testing included acquiring images, image registration, receiving correction vectors and applying the corrections to the robotic patient positioner. Results: Gamma Index analysis of the Treatment Planning System (TPS) data vs. Measured data showed more than 90% of points within (3%, 3mm) for the maps created by the TPS. At Isocenter Beam Size (One sigma) < 3mm at highest energy (250 MeV) in air. Beam delivery was within 0.6 mm of the intended target at the entrance and the exit of the beam, through the phantom. Conclusion: The Radiance 330 Beam Performance Measurements have confirmed that the system operates as designed with excellent clinical

  7. SU-E-T-470: Beam Performance of the Radiance 330 Proton Therapy System

    Energy Technology Data Exchange (ETDEWEB)

    Nazaryan, H; Nazaryan, V; Wang, F [ProTom International, Inc., Flower Mound, TX (United States); Flanz, J [Massachusetts General Hospital, Boston, MA (United States); Alexandrov, V [ZAO ProTom, Protvino, Moscow region (Russian Federation)

    2014-06-01

    Purpose: The ProTom Radiance 330 proton radiotherapy system is a fully functional, compact proton radiotherapy system that provides advanced proton delivery capabilities. It supports three-dimensional beam scanning with energy and intensity modulation. A series of measurements have been conducted to characterize the beam performance of the first installation of the system at the McLaren Proton Therapy Center in Flint, Michigan. These measurements were part of the technical commissioning of the system. Select measurements and results are presented. Methods: The Radiance 330 proton beam energy range is 70–250 MeV for treatment, and up to 330 MeV for proton tomography and radiography. Its 3-D scanning capability, together with a small beam emittance and momentum spread, provides a highly efficient beam delivery. During the technical commissioning, treatment plans were created to deliver uniform maps at various energies to perform Gamma Index analysis. EBT3 Gafchromic films were irradiated using the Planned irradiation maps. Bragg Peak chamber was used to test the dynamic range during a scan in one layer for high (250 MeV) and Low (70 MeV) energies. The maximum and minimum range, range adjustment and modulation, distal dose falloff (80%–20%), pencil beam spot size, spot placement accuracy were also measured. The accuracy testing included acquiring images, image registration, receiving correction vectors and applying the corrections to the robotic patient positioner. Results: Gamma Index analysis of the Treatment Planning System (TPS) data vs. Measured data showed more than 90% of points within (3%, 3mm) for the maps created by the TPS. At Isocenter Beam Size (One sigma) < 3mm at highest energy (250 MeV) in air. Beam delivery was within 0.6 mm of the intended target at the entrance and the exit of the beam, through the phantom. Conclusion: The Radiance 330 Beam Performance Measurements have confirmed that the system operates as designed with excellent clinical

  8. Report of the Fixed-Target Proton-Accelerator Group

    International Nuclear Information System (INIS)

    Abe, K.; Bunce, G.; Fisk, G.

    1982-01-01

    The fixed target proton accelerator group divided itself into two roughly equal parts. One sub-group concentrated on a high intensity (10 14 protons/sec) moderate energy (30 GeV) machine while the other worked on a moderate intensity (5 x 10 11 protons/sec) very high energy (20 TeV) machine. For experiments where the total available energy is adequate, the fixed target option added to a anti p p 20 TeV collider ring has several attractive features: (1) high luminosity afforded by intense beams striking thick solid targets; (2) secondary beams of hadrons, photons, and leptons; and (3) the versatility of a fixed target facility, where many experiments can be performed independently. The proposed experiments considered by the subgroup, including neutrino, photon, hadron, and very short lived particle beams were based both on scaled up versions of similar experiments proposed for Tevatron II at Fermilab and on the 400 GeV fixed target programs at Fermilab and CERN

  9. Scintillator-CCD camera system light output response to dosimetry parameters for proton beam range measurement

    Energy Technology Data Exchange (ETDEWEB)

    Daftari, Inder K., E-mail: idaftari@radonc.ucsf.edu [Department of Radiation Oncology, 1600 Divisadero Street, Suite H1031, University of California-San Francisco, San Francisco, CA 94143 (United States); Castaneda, Carlos M.; Essert, Timothy [Crocker Nuclear Laboratory,1 Shields Avenue, University of California-Davis, Davis, CA 95616 (United States); Phillips, Theodore L.; Mishra, Kavita K. [Department of Radiation Oncology, 1600 Divisadero Street, Suite H1031, University of California-San Francisco, San Francisco, CA 94143 (United States)

    2012-09-11

    The purpose of this study is to investigate the luminescence light output response in a plastic scintillator irradiated by a 67.5 MeV proton beam using various dosimetry parameters. The relationship of the visible scintillator light with the beam current or dose rate, aperture size and the thickness of water in the water-column was studied. The images captured on a CCD camera system were used to determine optimal dosimetry parameters for measuring the range of a clinical proton beam. The method was developed as a simple quality assurance tool to measure the range of the proton beam and compare it to (a) measurements using two segmented ionization chambers and water column between them, and (b) with an ionization chamber (IC-18) measurements in water. We used a block of plastic scintillator that measured 5 Multiplication-Sign 5 Multiplication-Sign 5 cm{sup 3} to record visible light generated by a 67.5 MeV proton beam. A high-definition digital video camera Moticam 2300 connected to a PC via USB 2.0 communication channel was used to record images of scintillation luminescence. The brightness of the visible light was measured while changing beam current and aperture size. The results were analyzed to obtain the range and were compared with the Bragg peak measurements with an ionization chamber. The luminescence light from the scintillator increased linearly with the increase of proton beam current. The light output also increased linearly with aperture size. The relationship between the proton range in the scintillator and the thickness of the water column showed good linearity with a precision of 0.33 mm (SD) in proton range measurement. For the 67.5 MeV proton beam utilized, the optimal parameters for scintillator light output response were found to be 15 nA (16 Gy/min) and an aperture size of 15 mm with image integration time of 100 ms. The Bragg peak depth brightness distribution was compared with the depth dose distribution from ionization chamber measurements

  10. SU-E-T-610: Phosphor-Based Fiber Optic Probes for Proton Beam Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Darafsheh, A; Soldner, A; Liu, H; Kassaee, A; Zhu, T; Finlay, J [Univ Pennsylvania, Philadelphia, PA (United States)

    2015-06-15

    Purpose: To investigate feasibility of using fiber optics probes with rare-earth-based phosphor tips for proton beam radiation dosimetry. We designed and fabricated a fiber probe with submillimeter resolution (<0.5 mm3) based on TbF3 phosphors and evaluated its performance for measurement of proton beam including profiles and range. Methods: The fiber optic probe with TbF3 phosphor tip, embedded in tissue-mimicking phantoms was irradiated with double scattering proton beam with energy of 180 MeV. Luminescence spectroscopy was performed by a CCD-coupled spectrograph to analyze the emission spectra of the fiber tip. In order to measure the spatial beam profile and percentage depth dose, we used singular value decomposition method to spectrally separate the phosphors ionoluminescence signal from the background Cerenkov radiation signal. Results: The spectra of the TbF3 fiber probe showed characteristic ionoluminescence emission peaks at 489, 542, 586, and 620 nm. By using singular value decomposition we found the contribution of the ionoluminescence signal to measure the percentage depth dose in phantoms and compared that with measurements performed with ion chamber. We observed quenching effect at the spread out Bragg peak region, manifested as under-responding of the signal, due to the high LET of the beam. However, the beam profiles were not dramatically affected by the quenching effect. Conclusion: We have evaluated the performance of a fiber optic probe with submillimeter resolution for proton beam dosimetry. We demonstrated feasibility of spectral separation of the Cerenkov radiation from the collected signal. Such fiber probes can be used for measurements of proton beams profile and range. The experimental apparatus and spectroscopy method developed in this work provide a robust platform for characterization of proton-irradiated nanophosphor particles for ultralow fluence photodynamic therapy or molecular imaging applications.

  11. Pencil beam proton radiography using a multilayer ionization chamber

    NARCIS (Netherlands)

    Farace, Paolo; Righetto, Roberto; Meijers, Arturs

    2016-01-01

    A pencil beam proton radiography (PR) method, using a commercial multilayer ionization chamber (MLIC) integrated with a treatment planning system (TPS) was developed. A Giraffe (IBA Dosimetry) MLIC (+/- 0.5 mm accuracy) was used to obtain pencil beam PR by delivering spots uniformly positioned at a

  12. IKOR - An isochronous pulse compressor ring for proton beams

    International Nuclear Information System (INIS)

    Schaffer, G.

    1981-06-01

    This report contains the results of a study carried out for an isochronous compressor ring IKOR which compresses the 500 μs linac macropulses into pulses of 0.68 μs length. Its basic component is a ring magnet with alternating gradient and separated functions. Due to the isochronous operation, an rf system can be avoided which otherwise would be necessary in order to maintain a void in the circulating beam for the purpose of ejection. Injection is performed by charge exchange. The H - beam of the accelerator is first converted into a H 0 beam by stripping off one electron by a high gradient magnet placed in the transfer channel. Subsequently, the beam is converted into a proton beam by removing the remaining electron through a stripping foil in the ring. IKOR will be filled in 658 turns. Immediately after filling, the beam is ejected in a single turn via a kicker and a septum magnet and is transported to the spallation target. Because of the high intensity of 2.7 x 10 14 protons per pulse and, secondly, due to the high repetition rate of 100 Hz, beam dynamics and radiation protection aspects dominate the design and are, for this reason, treated in detail. (orig.)

  13. Injector and beam transport simulation study of proton dielectric wall accelerator

    International Nuclear Information System (INIS)

    Zhao, Quantang; Yuan, P.; Zhang, Z.M.; Cao, S.C; Shen, X.K.; Jing, Y.; Ma, Y.Y.; Yu, C.S.; Li, Z.P.; Liu, M.; Xiao, R.Q.; Zhao, H.W.

    2012-01-01

    A simulation study of a short-pulsed proton injector for, and beam transport in, a dielectric wall accelerator (DWA) has been carried out using the particle-in-cell (PIC) code Warp. It was shown that applying “tilt pulse” voltage waveforms on three electrodes enables the production of a shorter bunch by the injector. The fields in the DWA beam tube were simulated using Computer Simulation Technology’s Microwave Studio (CST MWS) package, with various choices for the boundary conditions. For acceleration in the DWA, the beam transport was simulated with Warp, using applied fields obtained by running CST MWS. Our simulations showed that the electric field at the entrance to the DWA represents a challenging issue for the beam transport. We thus simulated a configuration with a mesh at the entrance of the DWA, intended to improve the entrance field. In these latter simulations, a proton bunch was successfully accelerated from 130 keV to about 36 MeV in a DWA with a length of 36.75 cm. As the beam bunch progresses, its transverse dimensions diminish from (roughly) 0.5×0.5 cm to 0.2×0.4 cm. The beam pulse lengthens from 1 cm to 2 cm due to lack of longitudinal compression fields. -- Highlights: ► A pulse proton injector with tilt voltages on the three electrodes was simulated. ► The fields in different part of the DWA were simulated with CST and analyzed. ► The proton beam transport in DWA was simulated with Warp successfully. ► The simulation can help for designing a real DWA.

  14. Reference dosimetry of proton pencil beams based on dose-area product: a proof of concept.

    Science.gov (United States)

    Gomà, Carles; Safai, Sairos; Vörös, Sándor

    2017-06-21

    This paper describes a novel approach to the reference dosimetry of proton pencil beams based on dose-area product ([Formula: see text]). It depicts the calibration of a large-diameter plane-parallel ionization chamber in terms of dose-area product in a 60 Co beam, the Monte Carlo calculation of beam quality correction factors-in terms of dose-area product-in proton beams, the Monte Carlo calculation of nuclear halo correction factors, and the experimental determination of [Formula: see text] of a single proton pencil beam. This new approach to reference dosimetry proves to be feasible, as it yields [Formula: see text] values in agreement with the standard and well-established approach of determining the absorbed dose to water at the centre of a broad homogeneous field generated by the superposition of regularly-spaced proton pencil beams.

  15. Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital-based clinical cyclotron

    International Nuclear Information System (INIS)

    Jones, Kevin C.; Solberg, Timothy D.; Avery, Stephen; Vander Stappen, François; Janssens, Guillaume; Prieels, Damien; Bawiec, Christopher R.; Lewin, Peter A.; Sehgal, Chandra M.

    2015-01-01

    Purpose: To measure the acoustic signal generated by a pulsed proton spill from a hospital-based clinical cyclotron. Methods: An electronic function generator modulated the IBA C230 isochronous cyclotron to create a pulsed proton beam. The acoustic emissions generated by the proton beam were measured in water using a hydrophone. The acoustic measurements were repeated with increasing proton current and increasing distance between detector and beam. Results: The cyclotron generated proton spills with rise times of 18 μs and a maximum measured instantaneous proton current of 790 nA. Acoustic emissions generated by the proton energy deposition were measured to be on the order of mPa. The origin of the acoustic wave was identified as the proton beam based on the correlation between acoustic emission arrival time and distance between the hydrophone and proton beam. The acoustic frequency spectrum peaked at 10 kHz, and the acoustic pressure amplitude increased monotonically with increasing proton current. Conclusions: The authors report the first observation of acoustic emissions generated by a proton beam from a hospital-based clinical cyclotron. When modulated by an electronic function generator, the cyclotron is capable of creating proton spills with fast rise times (18 μs) and high instantaneous currents (790 nA). Measurements of the proton-generated acoustic emissions in a clinical setting may provide a method for in vivo proton range verification and patient monitoring

  16. A proton beam delivery system for conformal therapy and intensity modulated therapy

    International Nuclear Information System (INIS)

    Yu Qingchang

    2001-01-01

    A scattering proton beam delivery system for conformal therapy and intensity modulated therapy is described. The beam is laterally spread out by a dual-ring double scattering system and collimated by a program-controlled multileaf collimator and patient specific fixed collimators. The proton range is adjusted and modulated by a program controlled binary filter and ridge filters

  17. Experimental characterization and physical modelling of the dose distribution of scanned proton pencil beams

    International Nuclear Information System (INIS)

    Pedroni, E; Scheib, S; Boehringer, T; Coray, A; Grossmann, M; Lin, S; Lomax, A

    2005-01-01

    In this paper we present the pencil beam dose model used for treatment planning at the PSI proton gantry, the only system presently applying proton therapy with a beam scanning technique. The scope of the paper is to give a general overview on the various components of the dose model, on the related measurements and on the practical parametrization of the results. The physical model estimates from first physical principles absolute dose normalized to the number of incident protons. The proton beam flux is measured in practice by plane-parallel ionization chambers (ICs) normalized to protons via Faraday-cup measurements. It is therefore possible to predict and deliver absolute dose directly from this model without other means. The dose predicted in this way agrees very well with the results obtained with ICs calibrated in a cobalt beam. Emphasis is given in this paper to the characterization of nuclear interaction effects, which play a significant role in the model and are the major source of uncertainty in the direct estimation of the absolute dose. Nuclear interactions attenuate the primary proton flux, they modify the shape of the depth-dose curve and produce a faint beam halo of secondary dose around the primary proton pencil beam in water. A very simple beam halo model has been developed and used at PSI to eliminate the systematic dependences of the dose observed as a function of the size of the target volume. We show typical results for the relative (using a CCD system) and absolute (using calibrated ICs) dosimetry, routinely applied for the verification of patient plans. With the dose model including the nuclear beam halo we can predict quite precisely the dose directly from treatment planning without renormalization measurements, independently of the dose, shape and size of the dose fields. This applies also to the complex non-homogeneous dose distributions required for the delivery of range-intensity-modulated proton therapy, a novel therapy technique

  18. Radiosensitization by PARP inhibition to proton beam irradiation in cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Hirai, Takahisa [Department of Radiation Oncology, Juntendo University Faculty of Medicine, Bunkyo-ku, Tokyo (Japan); Division of Chemotherapy and Clinical Cancer Research, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan); Saito, Soichiro; Fujimori, Hiroaki [Division of Chemotherapy and Clinical Cancer Research, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan); Matsushita, Keiichiro; Nishio, Teiji [Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima-shi, Hiroshima (Japan); Okayasu, Ryuichi [International Open Laboratory, National Institute of Radiological Science, Chiba-shi, Chiba (Japan); Masutani, Mitsuko, E-mail: mmasutan@nagasaki-u.ac.jp [Division of Chemotherapy and Clinical Cancer Research, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan); Department of Frontier Life Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki (Japan)

    2016-09-09

    The poly(ADP-ribose) polymerase (PARP)-1 regulates DNA damage responses and promotes base excision repair. PARP inhibitors have been shown to enhance the cytotoxicity of ionizing radiation in various cancer cells and animal models. We have demonstrated that the PARP inhibitor (PARPi) AZD2281 is also an effective radiosensitizer for carbon-ion radiation; thus, we speculated that the PARPi could be applied to a wide therapeutic range of linear energy transfer (LET) radiation as a radiosensitizer. Institutes for biological experiments using proton beam are limited worldwide. This study was performed as a cooperative research at heavy ion medical accelerator in Chiba (HIMAC) in National Institute of Radiological Sciences. HIMAC can generate various ion beams; this enabled us to compare the radiosensitization effect of the PARPi on cells subjected to proton and carbon-ion beams from the same beam line. After physical optimization of proton beam irradiation, the radiosensitization effect of the PARPi was assessed in the human lung cancer cell line, A549, and the pancreatic cancer cell line, MIA PaCa-2. The effect of the PARPi, AZD2281, on radiosensitization to Bragg peak was more significant than that to entrance region. The PARPi increased the number of phosphorylated H2AX (γ-H2AX) foci and enhanced G2/M arrest after proton beam irradiation. This result supports our hypothesis that a PARPi could be applied to a wide therapeutic range of LET radiation by blocking the DNA repair response. - Highlights: • Effective radiosensitizers for particle radiation therapy have not been reported. • PARP inhibitor treatment radiosensitized after proton beam irradiation. • The sensitization at Bragg peak was greater than that at entrance region. • DSB induction and G2/M arrest is involved in the sensitization mechanism.

  19. Microfabrication of biocompatible hydrogels by proton beam writing

    Science.gov (United States)

    Nagasawa, Naotsugu; Kimura, Atsushi; Idesaki, Akira; Yamada, Naoto; Koka, Masashi; Satoh, Takahiro; Ishii, Yasuyuki; Taguchi, Mitsumasa

    2017-10-01

    Functionalization of biocompatible materials is expected to be widely applied in biomedical engineering and regenerative medicine fields. Hydrogel has been expected as a biocompatible scaffold which support to keep an organ shape during cell multiplying in regenerative medicine. Therefore, it is important to understanding a surface microstructure (minute shape, depth of flute) and a chemical characteristic of the hydrogel affecting the cell culture. Here, we investigate the microfabrication of biocompatible polymeric materials, such as the water-soluble polysaccharide derivatives hydroxypropyl cellulose and carboxymethyl cellulose, by use of proton beam writing (PBW). These polymeric materials were dissolved thoroughly in pure water using a planetary centrifugal mixer, and a sample sheet (1 mm thick) was formed on polyethylene terephthalate (PET) film. Crosslinking to form hydrogels was induced using a 3.0 MeV focused proton beam from the single-ended accelerator at Takasaki Ion Accelerators for Advanced Radiation Application. The aqueous samples were horizontally irradiated with the proton beam through the PET cover film, and then rinsed with deionized water. Microstructured hydrogels were obtained on the PET film using the PBW technique without toxic crosslinking reagents. Cell adhesion and proliferation on the microfabricated biocompatible hydrogels were investigated. Microfabrication of HPC and CMC by the use of PBW is expected to produce new biocompatible materials that can be applied in biological and medical applications.

  20. Preliminary results of an in-beam PET prototype for proton therapy

    International Nuclear Information System (INIS)

    Attanasi, F.; Belcari, N.; Camarda, M.; Cirrone, G.A.P.; Cuttone, G.; Del Guerra, A.; Di Rosa, F.; Lanconelli, N.; Rosso, V.; Russo, G.; Vecchio, S.

    2008-01-01

    Proton therapy can overcome the limitations of conventional radiotherapy due to the more selective energy deposition in depth and to the increased biological effectiveness. Verification of the delivered dose is desirable, but the complete stopping of the protons in patient prevents the application of electronic portal imaging methods that are used in conventional radiotherapy During proton therapy β + emitters like 11 C, 15 O, 10 C are generated in irradiated tissues by nuclear reactions. The measurement of the spatial distribution of this activity, immediately after patient irradiation, can lead to information on the effective delivered dose. First, results of a feasibility study of an in-beam PET for proton therapy are reported. The prototype is based on two planar heads with an active area of about 5x5 cm 2 . Each head is made up of a position sensitive photomultiplier coupled to a square matrix of same size of LYSO scintillating crystals (2x2x18 mm 3 pixel dimensions). Four signals from each head are acquired through a dedicated electronic board that performs signal amplification and digitization. A 3D reconstruction of the activity distribution is calculated using an expectation maximization algorithm. To characterize the PET prototype, the detection efficiency and the spatial resolution were measured using a point-like radioactive source. The validation of the prototype was performed using 62 MeV protons at the CATANA beam line of INFN LNS and PMMA phantoms. Using the full energy proton beam and various range shifters, a good correlation between the position of the activity distal edge and the thickness of the beam range shifter was found along the axial direction

  1. Preliminary results of an in-beam PET prototype for proton therapy

    Science.gov (United States)

    Attanasi, F.; Belcari, N.; Camarda, M.; Cirrone, G. A. P.; Cuttone, G.; Del Guerra, A.; Di Rosa, F.; Lanconelli, N.; Rosso, V.; Russo, G.; Vecchio, S.

    2008-06-01

    Proton therapy can overcome the limitations of conventional radiotherapy due to the more selective energy deposition in depth and to the increased biological effectiveness. Verification of the delivered dose is desirable, but the complete stopping of the protons in patient prevents the application of electronic portal imaging methods that are used in conventional radiotherapy During proton therapy β + emitters like 11C, 15O, 10C are generated in irradiated tissues by nuclear reactions. The measurement of the spatial distribution of this activity, immediately after patient irradiation, can lead to information on the effective delivered dose. First, results of a feasibility study of an in-beam PET for proton therapy are reported. The prototype is based on two planar heads with an active area of about 5×5 cm 2. Each head is made up of a position sensitive photomultiplier coupled to a square matrix of same size of LYSO scintillating crystals (2×2×18 mm 3 pixel dimensions). Four signals from each head are acquired through a dedicated electronic board that performs signal amplification and digitization. A 3D reconstruction of the activity distribution is calculated using an expectation maximization algorithm. To characterize the PET prototype, the detection efficiency and the spatial resolution were measured using a point-like radioactive source. The validation of the prototype was performed using 62 MeV protons at the CATANA beam line of INFN LNS and PMMA phantoms. Using the full energy proton beam and various range shifters, a good correlation between the position of the activity distal edge and the thickness of the beam range shifter was found along the axial direction.

  2. Preliminary results of an in-beam PET prototype for proton therapy

    Energy Technology Data Exchange (ETDEWEB)

    Attanasi, F.; Belcari, N.; Camarda, M. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy); Cirrone, G.A.P.; Cuttone, G. [INFN Laboratori Nazionali del Sud, Catania (Italy); Del Guerra, A. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy); Di Rosa, F. [INFN Laboratori Nazionali del Sud, Catania (Italy); Lanconelli, N. [Department of Physics, University of Bologna and INFN Sezione di Bologna, Bologna (Italy); Rosso, V. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy)], E-mail: valeria.rosso@pi.infn.it; Russo, G. [INFN Laboratori Nazionali del Sud, Catania (Italy); Vecchio, S. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy)

    2008-06-11

    Proton therapy can overcome the limitations of conventional radiotherapy due to the more selective energy deposition in depth and to the increased biological effectiveness. Verification of the delivered dose is desirable, but the complete stopping of the protons in patient prevents the application of electronic portal imaging methods that are used in conventional radiotherapy During proton therapy {beta}{sup +} emitters like {sup 11}C, {sup 15}O, {sup 10}C are generated in irradiated tissues by nuclear reactions. The measurement of the spatial distribution of this activity, immediately after patient irradiation, can lead to information on the effective delivered dose. First, results of a feasibility study of an in-beam PET for proton therapy are reported. The prototype is based on two planar heads with an active area of about 5x5 cm{sup 2}. Each head is made up of a position sensitive photomultiplier coupled to a square matrix of same size of LYSO scintillating crystals (2x2x18 mm{sup 3} pixel dimensions). Four signals from each head are acquired through a dedicated electronic board that performs signal amplification and digitization. A 3D reconstruction of the activity distribution is calculated using an expectation maximization algorithm. To characterize the PET prototype, the detection efficiency and the spatial resolution were measured using a point-like radioactive source. The validation of the prototype was performed using 62 MeV protons at the CATANA beam line of INFN LNS and PMMA phantoms. Using the full energy proton beam and various range shifters, a good correlation between the position of the activity distal edge and the thickness of the beam range shifter was found along the axial direction.

  3. Application of activity pencil beam algorithm using measured distribution data of positron emitter nuclei for therapeutic SOBP proton beam

    International Nuclear Information System (INIS)

    Miyatake, Aya; Nishio, Teiji

    2013-01-01

    Purpose: Recently, much research on imaging the clinical proton-irradiated volume using positron emitter nuclei based on target nuclear fragment reaction has been carried out. The purpose of this study is to develop an activity pencil beam (APB) algorithm for a simulation system for proton-activated positron-emitting imaging in clinical proton therapy using spread-out Bragg peak (SOBP) beams.Methods: The target nuclei of activity distribution calculations are 12 C nuclei, 16 O nuclei, and 40 Ca nuclei, which are the main elements in a human body. Depth activity distributions with SOBP beam irradiations were obtained from the material information of ridge filter (RF) and depth activity distributions of compounds of the three target nuclei measured by BOLPs-RGp (beam ON-LINE PET system mounted on a rotating gantry port) with mono-energetic Bragg peak (MONO) beam irradiations. The calculated data of depth activity distributions with SOBP beam irradiations were sorted in terms of kind of nucleus, energy of proton beam, SOBP width, and thickness of fine degrader (FD), which were verified. The calculated depth activity distributions with SOBP beam irradiations were compared with the measured ones. APB kernels were made from the calculated depth activity distributions with SOBP beam irradiations to construct a simulation system using the APB algorithm for SOBP beams.Results: The depth activity distributions were prepared using the material information of RF and the measured depth activity distributions with MONO beam irradiations for clinical therapy using SOBP beams. With the SOBP width widening, the distal fall-offs of depth activity distributions and the difference from the depth dose distributions were large. The shapes of the calculated depth activity distributions nearly agreed with those of the measured ones upon comparison between the two. The APB kernels of SOBP beams were prepared by making use of the data on depth activity distributions with SOBP beam

  4. Status of the anti-proton production beam in the CERN PS

    International Nuclear Information System (INIS)

    Cappi, R.; Evans, B.J.; Garoby, R.

    1990-01-01

    A new scheme was put into operation in November 1988 to upgrade the proton beam delivered by the 26 GeV Proton Synchrotron (PS) for anti-proton production. It makes use of quasi-adiabatic manipulations of the RF parameters to squeeze a beam filling 1/2 of the PS circumference into a 1/4 turn and can in theory preserve the longitudinal emittance. A maximum intensity of 1.68 e 13 ppp in 5 bunches at 26 GeV has been reached in the course of 22 weeks of operation. The limitations of the performance are analysed together with possible improvements. (author) 6 refs., 9 figs

  5. Treatment of the uterus cervix cancer with the JINR phasotron proton beam

    International Nuclear Information System (INIS)

    Astrakhan, B.V.; Kiseleva, V.N.; Pojdenko, V.K.; Klochkov, I.I.; Molokanov, A.G.; Mitsin, G.V.; Savchenko, O.V.; Zorin, V.P.

    1995-01-01

    The methods of the uterus cervix cancer proton-and-gamma treatment for the first time were elaborated in the CRC RAMS and ITEP in Moscow and then developed for the JINR proton beam in Dubna. The results of the clinical probation of the methods for the uterus cervix cancer treatment have confirmed the advantage of the proton irradiation. The most important advantage of the proton beam treatment is absence of postradiation reactions and complications in the critical organs (bladder and rectum). Up to now 31 patients with the uterus cervix cancer have been treated at the JINR phasotron. 6 of them had proton-and-gamma treatment combined with surgical operation and 22 patients received a radical proton-and-gamma treatment (without surgery). The clinical results are in good agreement with the preceding results of the ITEP group. After receiving proton-and-gamma radiotherapy of the uterus cervix, 83% of the patients are alive without recurrences, metastases and complications. 10 refs., 4 figs., 2 tabs

  6. Possibilities and conditions of applying PIXE analysis with external proton beam

    International Nuclear Information System (INIS)

    Potocek, V.

    1989-01-01

    The technical and methodological prerequisites are summed up for the use of the PIXE method with an external proton beam. The method is suitable for the preliminary analysis of unknown samples prior to the choice of the best suited analytical method, for the nondestructive analysis of rare samples such as unique works of art, of small amounts of materials which are difficult to access, etc., as well as for calibration and comparing analyses. As for the operators the application of the PIXE method with external proton beam assumes the availability of accelerator operating time, minimization of the length of exposure of the targets, optimization of parameters of the exciting beam and automation of the whole process. Attention is also devoted to technical provisions and organization of laboratory work. The design is described of an analytical unit using the PIXE method with external proton beam, and it is stated that the Van de Graaff accelerator at the Institute of Nuclear Physics in Rez near Prague could be used for the purpose. (Z.M.). 6 refs

  7. Bunching and phase focusing of laser generated proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Schumacher, Dennis; Hofmann, Ingo; Blazevic, Abel; Deppert, Oliver [GSI Helmholtzzentrum fuer Schwerionenforschung (Germany); Busold, Simon; Roth, Markus; Boine-Frankenheim, Oliver [TU Darmstadt (Germany); Brabetz, Christian [Universitaet Frankfurt, Frankfurt am Main (Germany); Zielbauer, Bernhard [HI Jena (Germany); Collaboration: LIGHT-Collaboration

    2013-07-01

    Laser accelerated proton beams can reach very high intensities and very low emittances. Therefore they are suitable as ion sources for many applications. One is the coupling into common ion accelerator structures to replace pre accelerators that are used so far. The LIGHT (Laser Ion Generation, Handling and Transport) collaboration has been founded to develop ion optics and targets and optimize laser parameter to make this coupling most efficient. In a first step a short pulse beam line for the PHELIX-laser at GSI to the experiment site Z6 has been build in order to laser accelerate protons here. In a second step a pulsed solenoid has been established to collimate the divergent ion beam. In a third step this collimated beam will be coupled into a bunching unit, which consists of a spiral resonator with three gaps which leads to an overall acceleration voltage of 1 MV. With this cavity it is not only possible to avoid the broadening of the pulse, but also to phase focus it. This talk presents also the progress towards the operation of the spiral resonator as buncher for a laser accelerated ion beam e.g. simulations, tests and performance data and shows the next steps of the beam shaping efforts.

  8. MEIC Proton Beam Formation with a Low Energy Linac

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yuhong [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)

    2015-09-01

    The MEIC proton and ion beams are generated, accumulated, accelerated and cooled in a new green-field ion injector complex designed specifically to support its high luminosity goal. This injector consists of sources, a linac and a small booster ring. In this paper we explore feasibility of a short ion linac that injects low-energy protons and ions into the booster ring.

  9. Warp simulations for capture and control of laser-accelerated proton beams

    International Nuclear Information System (INIS)

    Nuernberg, Frank; Harres, K; Roth, M; Friedman, A; Grote, D P; Logan, B G; Schollmeier, M

    2010-01-01

    The capture of laser-accelerated proton beams accompanied by co-moving electrons via a solenoid field has been studied with particle-in-cell simulations. The main advantages of the Warp simulation suite that we have used, relative to envelope or tracking codes, are the possibility of including all source parameters energy resolved, adding electrons as second species and considering the non-negligible space-charge forces and electrostatic self-fields. It was observed that the influence of the electrons is of vital importance. The magnetic effect on the electrons outbalances the space-charge force. Hence, the electrons are forced onto the beam axis and attract protons. Beside the energy dependent proton density increase on axis, the change in the particle spectrum is also important for future applications. Protons are accelerated/decelerated slightly, electrons highly. 2/3 of all electrons get lost directly at the source and 27% of all protons hit the inner wall of the solenoid.

  10. Response of a biological model to a proton beam in vivo

    International Nuclear Information System (INIS)

    Schuff, Juan A.; Burlon, Alejandro A.; Debray, Mario E.; Kesque, Jose M.; Kreiner, Andres J.; Stoliar, Pablo A.; Naab, Fabian; Ozafran, Mabel J.; Vazquez, Monica E.

    2000-01-01

    Wistar rats were locally irradiated with proton beams. By means of a plastic wedge used as an energy degradator of variable thickness, dorsal portions of skin were irradiated at several tissue depths. This model was used to perform proton irradiations with different doses in both the plateau and the Bragg portions of the Bragg curve. The particular geometry of the wedge, in which the maximum thickness is greater than the proton range, yields a portion of unaffected tissue included in the irradiated area. Thus, it was possible to obtain a reference zone contiguous to the affected area in the same animal. SSNTD were used to establish the spatial configuration and the dose of the proton beams. This methodology allows isodose curve calculations along the different tissue depths which are in agreement with the biologic effects observed. Additionally, the scattering of protons on the shielding material, that affects specific areas of the tissue, is detected by the SSNTD. (author)

  11. Warp simulations for capture and control of laser-accelerated proton beams

    International Nuclear Information System (INIS)

    Nurnberg, F.; Friedman, A.; Grote, D.P.; Harres, K.; Logan, B.G.; Schollmeier, M.; Roth, M.

    2009-01-01

    The capture of laser-accelerated proton beams accompanied by co-moving electrons via a solenoid field has been studied with particle-in-cell simulations. The main advantages of the Warp simulation suite that was used, relative to envelope or tracking codes, are the possibility of including all source parameters energy resolved, adding electrons as second species and considering the non-negligible space-charge forces and electrostatic self-fields. It was observed that the influence of the electrons is of vital importance. The magnetic effect on the electrons out balances the space-charge force. Hence, the electrons are forced onto the beam axis and attract protons. Besides the energy dependent proton density increase on axis, the change in the particle spectrum is also important for future applications. Protons are accelerated/decelerated slightly, electrons highly. 2/3 of all electrons get lost directly at the source and 27% of all protons hit the inner wall of the solenoid.

  12. The optics of secondary polarized proton beams

    International Nuclear Information System (INIS)

    Carey, D.C.

    1990-05-01

    Polarized protons can be produced by the parity-violating decay of either lambda or sigma hyperons. A secondary bema of polarized protons can then be produced without the difficult procedure of accelerating polarized protons. The preservation of the polarization while the protons are being transmitted to a final focus places stringent limitations on the optics of the beam line. The equations of motion of a polarized particle in a magnetic field have been solved to first order for quadrupole and dipole magnets. The lowest order terms indicate that the polarization vector will be restored to its original direction upon passage through a magnetic system if the momentum vector is unaltered. Higher-order terms may be derived by an expansion in commutators of the rotation matrix and its longitudinal derivative. The higher-order polarization rotation terms then arise from the non-commutivity of the rotation matrices by large angles in three-dimensional space. 5 refs., 3 figs

  13. Hard X-ray bremsstrahlung production in solar flares by high-energy proton beams

    Science.gov (United States)

    Emslie, A. G.; Brown, J. C.

    1985-01-01

    The possibility that solar hard X-ray bremsstrahlung is produced by acceleration of stationary electrons by fast-moving protons, rather than vice versa, as commonly assumed, was investigated. It was found that a beam of protons which involves 1836 times fewer particles, each having an energy 1836 times greater than that of the electrons in the equivalent electron beam model, has exactly the same bremsstrahlung yield for a given target, i.e., the mechanism has an energetic efficiency equal to that of conventional bremsstrahlung models. Allowance for the different degrees of target ionization appropriate to the two models (for conventional flare geometries) makes the proton beam model more efficient than the electron beam model, by a factor of order three. The model places less stringent constraints than a conventional electron beam model on the flare energy release mechanism. It is also consistent with observed X-ray burst spectra, intensities, and directivities. The altitude distribution of hard X-rays predicted by the model agrees with observations only if nonvertical injection of the protons is assumed. The model is inconsistent with gamma-ray data in terms of conventional modeling.

  14. Proton Beam Fast Ignition Fusion: Synergy of Weibel and Rayleigh-Taylor Instabilities

    Science.gov (United States)

    Stefan, V. Alexander

    2011-04-01

    The proton beam generation and focusing in fast ignition inertial confinement fusion is studied. The spatial and energy spread of the proton beam generated in a laser-solid interaction is increased due to the synergy of Weibel and Rayleigh-Taylor instabilities. The focal spot radius can reach 100 μm, which is nearly an order of magnitude larger than the optimal value. The energy spread decreases the beam deposition energy in the focal spot. Under these conditions, ignition of a precompressed DT fuel is achieved with the beam powers much higher than the values presently in consideration. Work supported in part by NIKOLA TESLA Laboratories (Stefan University), La Jolla, CA.

  15. A critical study of emittance measurements of intense low-energy proton beams

    CERN Document Server

    Evans, Lyndon R

    1972-01-01

    The measurement of emittance in low energy proton beams suffers from two perturbing effects: 1) the neutralisation of the beam by backstreaming secondary electrons and 2) the space charge blowup of the beam sample between defining and analysing apparatus. An experimental study shows a significant change of the emittance orientation when bias is used to eliminate the secondary electrons. Biased and non-biased cases are also compared with computed dynamics including space charge. Criteria for the slit size and drift distance which make the space charge blow-up negligible are derived. In addition a transverse coherent oscillation of the proton beam, which was revealed the measurements, is discussed briefly. (11 refs).

  16. Dosimetric performance evaluation regarding proton beam incident angles of a lithium-based AB-BNCT design

    International Nuclear Information System (INIS)

    Lee, Pei-Yi; Jiang, Shiang-Huei; Liu, Yuan-Hao

    2014-01-01

    The 7 Li(p,xn) 7 Be nuclear reaction, based on the low-energy protons, could produce soft neutrons for accelerator-based boron neutron capture therapy (AB-BNCT). Based on the fact that the induced neutron field is relatively divergent, the relationship between the incident angle of proton beam and the neutron beam quality was evaluated in this study. To provide an intense epithermal neutron beam, a beam-shaping assembly (BSA) was designed. And a modified Snyder head phantom was used in the calculations for evaluating the dosimetric performance. From the calculated results, the intensity of epithermal neutrons increased with the increase in proton incident angle. Hence, either the irradiation time or the required proton current can be reduced. When the incident angle of 2.5-MeV proton beam is 120 deg., the required proton current is ∼13.3 mA for an irradiation time of half an hour. The results of this study show that the BSA designs can generate neutron beams with good intensity and penetrability. Using a 20-mA, 2.5-MeV proton beam as the source, the required irradiation time, to induce 60 RBE-Gy of maximum tumour dose, is less than half an hour in any proton beam alignments. On the premise that the dosimetric performances are similar, the intensity of epithermal neutrons can be increased by using non-collinear (e.g. 90 deg., 120 deg.) incident protons. Thus, either the irradiation time or the required proton current can be reduced. The use of 120 deg. BSA model shows the possibility to reduce the required proton current to ∼13.3 mA when the goal of irradiation time is 30 min. The decrease of required proton beam current certainly will make the use of lithium target much easier. In June 2013, a 5-MeV, 30-mA radio frequency quadruple (RFQ) accelerator for BNCT was built at INFN-LNL (Legnaro National Laboratories, Italy), which shows a possibility to build a suitable RFQ accelerator for the authors' design. In addition, a 2.5-MeV, 30-mA Tandem accelerator was

  17. Results of treatment of Icenko-Cushing disease with proton beam irradiation of the pituitary gland

    International Nuclear Information System (INIS)

    Marova, E.I.; Starkova, N.T.; Kirpatovskaya, L.E.; Kolesnikova, G.S.; Bukhman, A.I.; Rozhinskaya, L.Ya.; Bel'chenko, L.V.

    1987-01-01

    Proton beam therapy was given to 98 patients with Icenko-Cushing disease aged 15 to 40. Mild cases were treated by proton beam irradiation only while severe cases were managed using proton beam therapy combined with unilateral adrenalectomy or ortho-para-DDD. Catamnesis duration varied from 3 to 5 years. In most cases the exposure dose was 80-90 Gy (50-110 Gy). The procedure was well tolerated by all the patients. A dynamic multipolar converting method with 15-20 entrance poles in the left temporal area was employed (with the beam energy of 200 MeV). Stabilization of the course of disease and some clinical improvement were observed in most of the patients 3-4 months after proton beam therapy. In 6-36 months after irradiation 90% of the patients showed normal biochemical indices and the absence of any clinical signs of the disease. Thus the results of proton beam therapy of 98 patients with Icenko-Cushing disease after a follow-up of 3-5 years showed a high efficacy of this type of treatment. The method can be used alone or in combination with unilateral adrenalectomy as well as with oral administration of ortho-para-DDD

  18. Collimator scatter and 2D dosimetry in small proton beams

    NARCIS (Netherlands)

    van Luijk, P.; van 't Veld, A.A.; Zelle, H.D.; Schippers, J.M.

    Monte Carlo simulations have been performed to determine the influence of collimator-scattered protons from a 150 MeV proton beam on the dose distribution behind a collimator. Slit-shaped collimators with apertures between 2 and 20 mm have been simulated. The Monte Carlo code GEANT 3.21 has been

  19. Progress in the production of intense ion beams and the formation of proton layers

    International Nuclear Information System (INIS)

    Kapetanakos, C.A.; Golden, J.; Marsh, S.J.; Mahaffey, R.A.

    1977-01-01

    The results on ion sources and the application of ion beams to the formation of proton layers and rings are presented. Ion beams have been produced on three different generators. Some results from the experiments performed on the Gamble 2 generator are presented. The Gamble 2 generator with coaxial anode-cathode configuration, hollow beam cross-section produces power levels of 0.6-1.2 MV with peak ion current of 200 kA. The number of protons in the beam 4x10 16 . Peak ion currents is excess 200 kA, energy 1 MeV, ion current density 1 kA/cm 2 . Magnetic field configuration to provide formation of strong proton layers is shown

  20. DC proton beam measurements in a single-solenoid low-energy beam transport system

    International Nuclear Information System (INIS)

    Stevens, R.R. Jr.; Schafstall, P.; Schneider, J.D.; Sherman, J.; Zaugg, T.; Taylor, T.

    1994-01-01

    High current, CW proton accelerators are being considered for a number of applications including disposition of nuclear wastes, reduction of fissionable nuclear material inventories, safe production of critical nuclear materials, and energy production. All these applications require the development of high current, reliable, hydrogen ion injectors. In 1986, a program using CW RFQ technology was undertaken at CRL in collaboration with LANL and was continued there until 1993. During this time, an accelerator was built which produced 600 keV, 75 mA and 1,250 keV, 55 mA CW proton beams. The present program at Los Alamos using this accelerator is aimed at continuing the CRL work to demonstrate long-term reliability. In the present work, the authors are seeking to determine the optimal match to and the current limit of the 1,250-keV RFQ. This paper discusses the characterization of the 50 keV beams at the exit of the single-solenoid LEBT and presents both the experimental measurements and the beam simulations done to model this system

  1. Requirements of a proton beam accelerator for an accelerator-driven reactor

    International Nuclear Information System (INIS)

    Takahashi, H.; Zhao, Y.; Tsoupas, N.; An, Y.; Yamazaki, Y.

    1997-01-01

    When the authors first proposed an accelerator-driven reactor, the concept was opposed by physicists who had earlier used the accelerator for their physics experiments. This opposition arose because they had nuisance experiences in that the accelerator was not reliable, and very often disrupted their work as the accelerator shut down due to electric tripping. This paper discusses the requirements for the proton beam accelerator. It addresses how to solve the tripping problem and how to shape the proton beam

  2. Comparison of dose distribution for proton beams and electrons: advantages and disadvantages; Comparacao de distribuicao de dose para feixes de protons e eletrons: vantagens e desvantagens

    Energy Technology Data Exchange (ETDEWEB)

    Neto, Joao T.M.; Ferreira, Maira B.; Braga, Victor B. [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil)

    2016-07-01

    This study consists of a simulation of cancer therapy using a beam of protons and electrons. By comparing dose distribution curves for both beams we have showed the advantages and disadvantages of both therapies. The study was performed with Monte Carlo simulations using Geant4 code for a brain tumor, and it was found that the presence of the Bragg peak in proton beam allows a higher dose deposition in tumor and protection of adjacent tissues, while the electron beam has an entry dose in the tissue higher than the proton, yielding to the tissue neighbors of the tumor, unnecessary radiation. Moreover, it was also found significant production of neutrons from the proton beam, showing its main disadvantage. The continuation of this work will add the comparison with clinical beams of photons. (author)

  3. Spin flipping a stored polarized proton beam

    International Nuclear Information System (INIS)

    Caussyn, D.D.; Derbenev, Y.S.; Ellison, T.J.P.; Lee, S.Y.; Rinckel, T.; Schwandt, P.; Sperisen, F.; Stephenson, E.J.; von Przewoski, B.; Blinov, B.B.; Chu, C.M.; Courant, E.D.; Crandell, D.A.; Kaufman, W.A.; Krisch, A.D.; Nurushev, T.S.; Phelps, R.A.; Ratner, L.G.; Wong, V.K.; Ohmori, C.

    1994-01-01

    We recently studied the spin flipping of a vertically polarized, stored 139-MeV proton beam. To flip the spin, we induced an rf depolarizing resonance by sweeping our rf solenoid magnet's frequency through the resonance frequency. With multiple spin flips, we found a polarization loss of 0.0000±0.0005 per spin flip under the best conditions; this loss increased significantly for small changes in the conditions. Minimizing the depolarization during each spin flip is especially important because frequent spin flipping could significantly reduce the systematic errors in stored polarized-beam experiments

  4. Manipulation of laser-accelerated proton beam profiles by nanostructured and microstructured targets

    Directory of Open Access Journals (Sweden)

    L. Giuffrida

    2017-08-01

    Full Text Available Nanostructured and microstructured thin foils have been fabricated and used experimentally as targets to manipulate the spatial profile of proton bunches accelerated through the interaction with high intensity laser pulses (6×10^{19}  W/cm^{2}. Monolayers of polystyrene nanospheres were placed on the rear surfaces of thin plastic targets to improve the spatial homogeneity of the accelerated proton beams. Moreover, thin targets with grating structures of various configurations on their rear sides were used to modify the proton beam divergence. Experimental results are presented, discussed, and supported by 3D particle-in-cell numerical simulations.

  5. Use of a two-dimensional ionization chamber array for proton therapy beam quality assurance

    International Nuclear Information System (INIS)

    Arjomandy, Bijan; Sahoo, Narayan; Ding Xiaoning; Gillin, Michael

    2008-01-01

    Two-dimensional ion chamber arrays are primarily used for conventional and intensity modulated radiotherapy quality assurance. There is no commercial device of such type available on the market that is offered for proton therapy quality assurance. We have investigated suitability of the MatriXX, a commercial two-dimensional ion chamber array detector for proton therapy QA. This device is designed to be used for photon and electron therapy QA. The device is equipped with 32x32 parallel plate ion chambers, each with 4.5 mm diam and 7.62 mm center-to-center separation. A 250 MeV proton beam was used to calibrate the dose measured by this device. The water equivalent thickness of the buildup material was determined to be 3.9 mm using a 160 MeV proton beam. Proton beams of different energies were used to measure the reproducibility of dose output and to evaluate the consistency in the beam flatness and symmetry measured by MatriXX. The output measurement results were compared with the clinical commissioning beam data that were obtained using a 0.6 cc Farmer chamber. The agreement was consistently found to be within 1%. The profiles were compared with film dosimetry and also with ion chamber data in water with an excellent agreement. The device is found to be well suited for quality assurance of proton therapy beams. It provides fast two-dimensional dose distribution information in real time with the accuracy comparable to that of ion chamber measurements and film dosimetry

  6. Energy spectrum control for modulated proton beams

    International Nuclear Information System (INIS)

    Hsi, Wen C.; Moyers, Michael F.; Nichiporov, Dmitri; Anferov, Vladimir; Wolanski, Mark; Allgower, Chris E.; Farr, Jonathan B.; Mascia, Anthony E.; Schreuder, Andries N.

    2009-01-01

    In proton therapy delivered with range modulated beams, the energy spectrum of protons entering the delivery nozzle can affect the dose uniformity within the target region and the dose gradient around its periphery. For a cyclotron with a fixed extraction energy, a rangeshifter is used to change the energy but this produces increasing energy spreads for decreasing energies. This study investigated the magnitude of the effects of different energy spreads on dose uniformity and distal edge dose gradient and determined the limits for controlling the incident spectrum. A multilayer Faraday cup (MLFC) was calibrated against depth dose curves measured in water for nonmodulated beams with various incident spectra. Depth dose curves were measured in a water phantom and in a multilayer ionization chamber detector for modulated beams using different incident energy spreads. Some nozzle entrance energy spectra can produce unacceptable dose nonuniformities of up to ±21% over the modulated region. For modulated beams and small beam ranges, the width of the distal penumbra can vary by a factor of 2.5. When the energy spread was controlled within the defined limits, the dose nonuniformity was less than ±3%. To facilitate understanding of the results, the data were compared to the measured and Monte Carlo calculated data from a variable extraction energy synchrotron which has a narrow spectrum for all energies. Dose uniformity is only maintained within prescription limits when the energy spread is controlled. At low energies, a large spread can be beneficial for extending the energy range at which a single range modulator device can be used. An MLFC can be used as part of a feedback to provide specified energy spreads for different energies.

  7. Calculation of multi-dimensional dose distribution in medium due to proton beam incidence

    International Nuclear Information System (INIS)

    Kawachi, Kiyomitsu; Inada, Tetsuo

    1978-01-01

    The method of analyzing the multi-dimensional dose distribution in a medium due to proton beam incidence is presented to obtain the reliable and simplified method from clinical viewpoint, especially for the medical treatment of cancer. The heavy ion beam being taken out of an accelerator has to be adjusted to fit cancer location and size, utilizing a modified range modulator, a ridge filter, a bolus and a special scanning apparatus. The precise calculation of multi-dimensional dose distribution of proton beam is needed to fit treatment to a limit part. The analytical formulas consist of those for the fluence distribution in a medium, the divergence of flying range, the energy distribution itself, the dose distribution in side direction and the two-dimensional dose distribution. The fluence distribution in polystyrene in case of the protons with incident energy of 40 and 60 MeV, the energy distribution of protons at the position of a Bragg peak for various values of incident energy, the depth dose distribution in polystyrene in case of the protons with incident energy of 40 and 60 MeV and average energy of 100 MeV, the proton fluence and dose distribution as functions of depth for the incident average energy of 250 MeV, the statistically estimated percentage errors in the proton fluence and dose distribution, the estimated minimum detectable tumor thickness as a function of the number of incident protons for the different incident spectra with average energy of 250 MeV, the isodose distribution in a plane containing the central axis in case of the incident proton beam of 3 mm diameter and 40 MeV and so on are presented as the analytical results, and they are evaluated. (Nakai, Y.)

  8. Proton-beam window design for a transmutation facility operating with a liquid lead target

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, C.; Lypsch, F.; Lizana, P. [Institute for Safety Research and Reactor Technology, Juelich (Germany)] [and others

    1995-10-01

    The proton beam target of an accelerator-driven transmutation facility can be designed as a vertical liquid lead column. To prevent lead vapor from entering the accelerator vacuum, a proton-beam window has to separate the area above the lead surface from the accelerator tube. Two radiation-cooled design alternatives have been investigated which should withstand a proton beam of 1.6 GeV and 25 mA. Temperature calculations based on energy deposition calculations with the Monte Carlo code HETC, stability analysis and spallation-induced damage calculations have been performed showing the applicability of both designs.

  9. Relative biological effectiveness (RBE) of proton beams in radiotherapy

    International Nuclear Information System (INIS)

    Calugaru, V.

    2011-01-01

    Treatment planning in proton therapy uses a generic value for the Relative Biological Efficiency (RBE) of 1.1 relative to 60 Co gamma-rays throughout the Spread Out Bragg Peak (SOBP). We have studied the variation of the RBE at three positions in the SOBP of the 76 and 201 MeV proton beams used for cancer treatment at the Institut Curie Proton Therapy in Orsay (ICPO) in two human tumor cell lines using clonogenic cell death and the incidence of DNA double-strand breaks (DSB) as measured by pulse-field gel electrophoresis without and with endonuclease treatment to reveal clustered lesions as endpoints.The RBE for induced cell killing by the 76 MeV beam increased with depth in the SOBP. However for the 201 MeV protons it was close to that for 137 Cs gamma-rays and did not vary significantly. The incidence of DSBs and clustered lesions was higher for protons than for 137 Cs g-rays, but did not depend on the proton energy or the position in the SOBP. In the second part of our work, we have shown using cell clones made deficient for known repair genes by stable or transient shRNA transfection, that the D-NHEJ pathway determine the response to protons. The response of DNA damages created in the distal part of the 76 MeV SOBP suggests that those damages belong to the class of DNA 'complex lesions' (LMDS). It also appears that the particle fluence is a major determinant of the outcome of treatment in the distal part of the SOBP. (author)

  10. Coherent production of {epsilon}{sup +} particles in crystal using proton beam from SSC

    Energy Technology Data Exchange (ETDEWEB)

    Okorokov, V.V.; Dubin, A.Yu. [ITER, Moscow, (Russian Federation)

    1995-05-01

    The unique possibilities of the SSC can be ideally used for a new generation of coherent generation experiments with relativistic protons which require 20 Tev energy of the incident beam. The availability of 20 Tev proton beam at SSC allows new experiments on coherent production of {var_epsilon}{sup +} particle by relativistic proton in crystal. Experiment carried out at low energies can now be extended with protons in very narrow energy region (resonance energy, which easy can be calculated) using the new accelerator facilities at SSC. We propose to study coherent production via the Coulomb field of the cristal atoms to excite the transition p + {gamma}{implies} {var_epsilon} {sup +} (1189).

  11. Measurement of proton-beam parameters by means of digital television diagnostic system

    International Nuclear Information System (INIS)

    Vazhenin, V.A.; Borovkov, S.D.; Evtikhiev, A.V.

    1992-01-01

    A method is described for measurement of the parameters of pulse-packet beams by means of a digital television diagnostic system. Results of tests of the system in measurement of the parameters of a proton beam with an energy of 1.35 GeV in the U-70 circular accelerator and results of measurements of the energy spectrum of the 30-MeV proton beam of the LU-30 linear accelerator are given. The possibility is shown of using the system to measure the integrated characteristics of an entire beam-pulse packet as well as the characteristics of individual pulses with a period of 60 msec. 6 refs., 4 figs., 1 tab

  12. Charge collection in an external proton beam

    International Nuclear Information System (INIS)

    Wookey, C.W.; Somswasdi, B.; Rouse, J.L.

    1982-01-01

    Results from the measurement of the stability of charge collected from the target and exit foil, or as alternatives, the γ-ray or backscattered proton counts from the exit foil and the Ar X-ray counts from the air path in an external proton beam are presented. These results show that comparative analysis of material mounted in air is reliable, using either the collected charge or the γ-ray counts as the normalizing factor, if there are no earthed objects in close geometry. The backscattered proton counts can also be used, but not the Ar X-ray counts, unless the current is stabilized. The electrical or thermal conductivity of the target and the target to exit foil separation do not affect the proportionality of the collected charge and the γ-ray counts to the charge incident on the target

  13. High intensity proton beam transportation through fringe field of 70 MeV compact cyclotron to beam line targets

    Science.gov (United States)

    Zhang, Xu; Li, Ming; Wei, Sumin; Xing, Jiansheng; Hu, Yueming; Johnson, Richard R.; Piazza, Leandro; Ryjkov, Vladimir

    2016-06-01

    From the stripping points, the high intensity proton beam of a compact cyclotron travels through the fringe field area of the machine to the combination magnet. Starting from there the beams with various energy is transferred to the switching magnet for distribution to the beam line targets. In the design of the extraction and transport system for the compact proton cyclotron facilities, such as the 70 MeV in France and the 100 MeV in China, the space charge effect as the beam crosses the fringe field has not been previously considered; neither has the impact on transverse beam envelope coupled from the longitudinal direction. Those have been concerned much more with the higher beam-power because of the beam loss problem. In this paper, based on the mapping data of 70 MeV cyclotron including the fringe field by BEST Cyclotron Inc (BEST) and combination magnet field by China Institute of Atomic Energy (CIAE), the beam extraction and transport are investigated for the 70 MeV cyclotron used on the SPES project at Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro (INFN-LNL). The study includes the space charge effect and longitudinal and transverse coupling mentioned above, as well as the matching of beam optics using the beam line for medical isotope production as an example. In addition, the designs of the ±45° switching magnets and the 60° bending magnet for the extracted beam with the energy from 35 MeV to 70 MeV have been made. Parts of the construction and field measurements of those magnets have been done as well. The current result shows that, the design considers the complexity of the compact cyclotron extraction area and fits the requirements of the extraction and transport for high intensity proton beam, especially at mA intensity levels.

  14. High intensity proton beam transportation through fringe field of 70 MeV compact cyclotron to beam line targets

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xu, E-mail: emmazhang103@gmail.com [China Institute of Atomic Energy (China); Li, Ming; Wei, Sumin; Xing, Jiansheng; Hu, Yueming [China Institute of Atomic Energy (China); Johnson, Richard R.; Piazza, Leandro; Ryjkov, Vladimir [BEST Cyclotron Inc (Canada)

    2016-06-01

    From the stripping points, the high intensity proton beam of a compact cyclotron travels through the fringe field area of the machine to the combination magnet. Starting from there the beams with various energy is transferred to the switching magnet for distribution to the beam line targets. In the design of the extraction and transport system for the compact proton cyclotron facilities, such as the 70 MeV in France and the 100 MeV in China, the space charge effect as the beam crosses the fringe field has not been previously considered; neither has the impact on transverse beam envelope coupled from the longitudinal direction. Those have been concerned much more with the higher beam-power because of the beam loss problem. In this paper, based on the mapping data of 70 MeV cyclotron including the fringe field by BEST Cyclotron Inc (BEST) and combination magnet field by China Institute of Atomic Energy (CIAE), the beam extraction and transport are investigated for the 70 MeV cyclotron used on the SPES project at Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro (INFN–LNL). The study includes the space charge effect and longitudinal and transverse coupling mentioned above, as well as the matching of beam optics using the beam line for medical isotope production as an example. In addition, the designs of the ±45° switching magnets and the 60° bending magnet for the extracted beam with the energy from 35 MeV to 70 MeV have been made. Parts of the construction and field measurements of those magnets have been done as well. The current result shows that, the design considers the complexity of the compact cyclotron extraction area and fits the requirements of the extraction and transport for high intensity proton beam, especially at mA intensity levels.

  15. Parameters of medical proton beam of JINR and study on its medical use

    International Nuclear Information System (INIS)

    Dzhelepov, V.P.; Abazov, V.M.; Komarov, V.I.; Kuz'min, E.S.; Reshetnikov, G.P.; Savchenko, O.V.; Cherevatenko, E.P.; Ruderman, A.I.; Astrakhan, B.V.; Vajnberg, M.Sh.

    1975-01-01

    Experiments are described on irradiation of deep-lying tumours in man with a proton beam on the Dubna synchrocyclotron. A proton beam with an energy of 680 MeV is focused on a braking filter of liquid paraffin or water, 1.5 m thick. The slowed-down protons are cleared of impurity particles by the magnetic field and are transported for about 30 m to clinical premises located behind a 2 m concrete shield. The total intensity and maximum density of the proton flux with an energy of 185 MeV are about 10 9 s -1 and 5x10 7 cm -2 s -1 , respectively. The results of dose measurements showed that the maximum dose rate is about 300 rad/min at a proton energy of 185 MeV, and about 120 rad/min at 90 MeV. The contribution of the secondary particles to the dose distribution is about 10%. Patients can be irradiated either in the static regime, or in the rotation regime, when the patient rotates about a vertical axis passing through the tumour centre. While the patient is rotating, all the changes in the thickness of the tissues through which the beam passes before it reaches the tumour, are automatically compensated by a change in the thickness of the water absorber installed in front of the patient. Irradiations of patients with surface tumours showed that the proton beam parameters and the technical equipment of the systems meet the medical requirements

  16. Non-Linear Beam Transport System for the LENS 7 MeV Proton Beam

    CERN Document Server

    Jones, William P; Derenchuk, Vladimir Peter; Rinckel, Thomas; Solberg, Keith

    2005-01-01

    A beam transport system has been designed to carry a high-intensity low-emittance proton beam from the exit of the RFQ-DTL acceleration system of the Indiana University Low Energy Neutron System (LENS)* to the neutron production target. The goal of the design was to provide a beam of uniform density over a 3cm by 3cm area at the target. Two octupole magnets** are employed in the beam line to provide the necessary beam phase space manipulations to achieve this goal. First order calculations were done using TRANSPORT and second order calculations have been performed using TURTLE. Second order simulations have been done using both a Gaussian beam distribution and a particle set generated by calculations of beam transport through the RFQ-DTL using PARMILA. Comparison of the design characteristics with initial measurements from the LENS commissioning process will be made.

  17. Commissioning of polarized-proton and antiproton beams at Fermilab

    International Nuclear Information System (INIS)

    Yokosawa, A.

    1988-01-01

    The author described the polarized-proton and polarized-antiproton beams up to 200 GeV/c at Fermilab. The beam line, called MP, consists of the 400-m long primary and 350-m long secondary beam line followed by 60-m long experimental hall. We discuss the characteristics of the polarized beams. The Fermilab polarization projects are designated at E-581/704 initiated and carried out by an international collaboration, Argonne (US), Fermilab (US), Kyoto-Kyushu-Hiroshima-KEK (Japan), LAPP (France), Northwestern University (US), Los Alamos Laboratory (US), Rice (US), Saclay (France), Serpukhov (USSR), INFN Trieste (Italy), and University of Texas (US)

  18. Anti-angiogenic activity in metastasis of human breast cancer cells irradiated by a proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyu-Shik; Shin, Jin-Sun; Nam, Kyung-Soo [Dongguk University, Gyeongju (Korea, Republic of); Shon, Yun-Hee [Kyungpook National University Hospital, Daegu (Korea, Republic of)

    2012-07-15

    Angiogenesis is an essential process of metastasis in human breast cancer. We investigated the effects of proton beam irradiation on angiogenic enzyme activities and their expressions in MCF-7 human breast cancer cells. The regulation of angiogenic regulating factors, of transforming growth factor-β (TGF-β) and of vesicular endothelial growth factor (VEGF) expression in breast cancer cells irradiated with a proton beam was studied. Aromatase activity and mRNA expression, which is correlated with metastasis, were significantly decreased by irradiation with a proton beam in a dose-dependent manner. TGF-β and VEGF transcriptions were also diminished by proton beam irradiation. In contrast, transcription of tissue inhibitors of matrix metalloproteinases (TIMPs), also known as biological inhibitors of matrix metalloproteinases (MMPs), was dose-dependently enhanced. Furthermore, an increase in the expression of TIMPs caused the MMP-9 activity to be diminished and the MMP-9 and the MMP-2 expressions to be decreased. These results suggest that inhibition of angiogenesis by proton beam irradiation in breast cancer cells is closely related to inhibitions of aromatase activity and transcription and to down-regulation of TGF-β and VEGF transcription.

  19. The water equivalence of solid materials used for dosimetry with small proton beams

    International Nuclear Information System (INIS)

    Schneider, Uwe; Pemler, Peter; Besserer, Juergen; Dellert, Matthias; Moosburger, Martin; Boer, Jorrit de; Pedroni, Eros; Boehringer, Terence

    2002-01-01

    Various solid materials are used instead of water for absolute dosimetry with small proton beams. This may result in a dose measurement different to that in water, even when the range of protons in the phantom material is considered correctly. This dose difference is caused by the diverse cross sections for inelastic nuclear scattering in water and in the phantom materials respectively. To estimate the magnitude of this effect, flux and dose measurements with a 177 MeV proton pencil beam having a width of 0.6 cm (FWHM) were performed. The proton flux and the deposited dose in the beam path were determined behind water, lucite, polyethylene, teflon, and aluminum of diverse thicknesses. The number of out-scattered protons due to inelastic nuclear scattering was determined for water and the different materials. The ratios of the number of scattered protons in the materials relative to that in water were found to be 1.20 for lucite, 1.16 for polyethylene, 1.22 for teflon, and 1.03 for aluminum. The difference between the deposited dose in water and in the phantom materials taken in the center of the proton pencil beam, was estimated from the flux measurements, always taking the different ranges of protons in the materials into account. The estimated dose difference relative to water in 15 cm water equivalent thickness was -2.3% for lucite, -1.7% for polyethylene, -2.5% for teflon, and -0.4% for aluminum. The dose deviation was verified by a measurement using an ionization chamber. It should be noted that the dose error is larger when the effective point of measurement in the material is deeper or when the energy is higher

  20. Studies on beam extraction from the 1 GeV proton accumulator ring

    International Nuclear Information System (INIS)

    Goyal, Pradeep Kumar; Sharma, Amalendu; Kumar, Vinit; Ghodke, A.D.

    2015-01-01

    For the proposed Indian Spallation Neutron Source (ISNS), a 1 GeV proton Accumulator Ring (AR) is presently being designed at RRCAT. Two optics configurations of AR, namely FODO and Hybrid lattices are under consideration. Each lattice configuration has four superperiods. In this paper, preliminary studies on beam extraction from AR are presented for both the optics configurations. The extraction system will be accommodated in one of the long dispersion free straight sections. Bunch length of the proton beam in AR is 700 ns, and the revolution time of the bunch in AR is 1 ms. This leaves a gap of ∼300 ns for bunch extraction. The proton bunch will be extracted to Ring to Target Beam Transport (RTBT) line, with the help of fast kicker and septum magnets. In this paper, we present the details of the beam extraction scheme with suitable number of kicker magnets, and find out their optimal location and strength. Estimation of field error tolerances for kicker magnets is also presented. (author)

  1. CHARACTERIZATION OF 27 MEV PROTON BEAM GENERATED BY TOP-IMPLART LINEAR ACCELERATOR.

    Science.gov (United States)

    De Angelis, C; Ampollini, A; Basile, E; Cisbani, E; Della Monaca, S; Ghio, F; Montereali, R M; Picardi, L; Piccinini, M; Placido, C; Ronsivalle, C; Soriani, A; Strigari, L; Trinca, E; Vadrucci, M

    2018-01-29

    The first proton linear accelerator for tumor therapy based on an actively scanned beam up to the energy of 150 MeV, is under development and construction by ENEA-Frascati, ISS and IFO, under the Italian TOP-IMPLART project. Protons up to the energy of 7 MeV are generated by a customized commercial injector operating at 425 MHz; currently three accelerating modules allow proton delivery with energy up to 27 MeV. Beam homogeneity and reproducibility were studied using a 2D ionizing chamber, EBT3 films, a silicon diode, MOSFETs, LiF crystals and alanine dosimetry systems. Measurements were taken in air with the detectors at ~1 m from the beam line exit window. The maximum energy impinging on the detectors surface was 24.1 MeV, an energy suitable for radiobiological studies. Results showed beam reproducibility within 5% and homogeneity within 4%, on a circular surface of 16 mm in diameter. © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  2. Methodologies and tools for proton beam design for lung tumors

    International Nuclear Information System (INIS)

    Moyers, Michael F.; Miller, Daniel W.; Bush, David A.; Slater, Jerry D.

    2001-01-01

    Purpose: Proton beams can potentially increase the dose delivered to lung tumors without increasing the dose to critical normal tissues because protons can be stopped before encountering the normal tissues. This potential can only be realized if tissue motion and planning uncertainties are correctly included during planning. This study evaluated several planning strategies to determine which method best provides adequate tumor coverage, minimal normal tissue irradiation, and simplicity of use. Methods and Materials: Proton beam treatment plans were generated using one or more of three different planning strategies. These strategies included designing apertures and boluses to the PTV, apertures to the PTV and boluses to the CTV, and aperture and bolus to the CTV. Results: The planning target volume as specified in ICRU Report 50 can be used only to design the lateral margins of beams, because the distal and proximal margins resulting from CT number uncertainty, beam range uncertainty, tissue motions, and setup uncertainties, are different than the lateral margins resulting from these same factors. The best strategy for target coverage with the planning tools available overirradiated some normal tissues unnecessarily. The available tools also made the planning of lung tumors difficult. Conclusions: This study demonstrated that inclusion of target motion and setup uncertainties into a plan should be performed in the beam design step instead of creating new targets. New computerized treatment planning system tools suggested by this study will ease planning, facilitate abandonment of the PTV concept, improve conformance of the dose distribution to the target, and improve conformal avoidance of critical normal tissues

  3. PDMS patterning by proton beam

    International Nuclear Information System (INIS)

    Szilasi, S.Z.; Huszank, R.; Csik, A.; Rajta, I.; Cserhati, C.

    2008-01-01

    Complete text of publication follows. In this paper the poly-(dimethylsiloxane) (PDMS) is introduced as a resist material for proton beam writing. We were looking for a biocompatible micropatternable polymer in which the chemical structure changes significantly due to proton beam exposure making the polymer capable of proton beam writing. PDMS is a commonly used silicon-based organic polymer, optically clear, and generally considered to be inert, non-toxic biocompatible polymer. PDMS is also notably hydrophobic, meaning that water cannot easily penetrate its surface. This property has led extended use of PDMS in microfluidics too. PDMS is a crosslinkable polymer, it acts like a rubbery solid when it is cross-linked. In this state, the polymer does not deform permanently under stress or strain. Up to now the PDMS has been used as a casting or replicating material in microfabrication to form microchannels, micromolding, or creating microstamps, etc. PDMS has not been used as a resist material for direct write techniques. In this work we investigated the surface topography of the irradiated regions of PDMS under and without stress (on the cut surface and on the original fluid surface, respectively). In the samples wherein stress was not developed, noticeable compaction was observed. In case of those samples wherein stress was developed, noticeable swelling occurred. During the irradiation around the actual position of the beam spot we experienced significant swelling that reduced in time. To determine the large scale remaining changes in the surface topography at the cut edges of the samples we used Scanning Electron Microscope (SEM). After numerous profilometer measurements we experienced that the irradiated areas became harder, so the probe could move on it without sinking. The unirradiated areas of the PDMS were so soft, that the probe sank in the medium even with the smallest load (5 x 10 -7 N). Because of this phenomenon the irradiated areas seem to be higher

  4. Comparison of the secondary electrons produced by proton and electron beams in water

    Energy Technology Data Exchange (ETDEWEB)

    Kia, Mohammad Reza, E-mail: m-r-kia@aut.ac.ir; Noshad, Houshyar [Department of Energy Engineering and Physics, Amirkabir University of Technology (Tehran Polytechnic), P.O. Box 15875-4413, Hafez Avenue, Tehran (Iran, Islamic Republic of)

    2016-05-15

    The secondary electrons produced in water by electron and proton beams are compared with each other. The total ionization cross section (TICS) for an electron impact in water is obtained by using the binary-encounter-Bethe model. Hence, an empirical equation based on two adjustable fitting parameters is presented to determine the TICS for proton impact in media. In order to calculate the projectile trajectory, a set of stochastic differential equations based on the inelastic collision, elastic scattering, and bremsstrahlung emission are used. In accordance with the projectile trajectory, the depth dose deposition, electron energy loss distribution in a certain depth, and secondary electrons produced in water are calculated. The obtained results for the depth dose deposition and energy loss distribution in certain depth for electron and proton beams with various incident energies in media are in excellent agreement with the reported experimental data. The difference between the profiles for the depth dose deposition and production of secondary electrons for a proton beam can be ignored approximately. But, these profiles for an electron beam are completely different due to the effect of elastic scattering on electron trajectory.

  5. SU-E-T-321: The Effects of a Dynamic Collimation System On Proton Pencil Beams to Improve Lateral Tissue Sparing in Spot Scanned Proton Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Hill, P; Wang, D; Flynn, R; Hyer, D [University Of Iowa, Iowa City, IA (United States)

    2014-06-01

    Purpose: To evaluate the lateral beam penumbra in pencil beam scanning proton therapy delivered using a dynamic collimator device capable of trimming a portion of the primary beam in close proximity to the patient. Methods: Monte Carlo simulations of pencil beams were performed using MCNPX. Each simulation transported a 125 MeV proton pencil beam through a range shifter, past acollimator, and into a water phantom. Two parameters were varied among the simulations, the source beam size (sigma in air from 3 to 9 mm), and the position of the edge of the collimator (placed from 0 to 30 mm from the central axis of the beam). Proton flux was tallied at the phantom surface to determine the effective beam sizefor all combinations of source beam size and collimator edge position. Results: Quantifying beam size at the phantom surface provides a useful measure tocompare performance among varying source beam sizes and collimation conditions. For arelatively large source beam size (9 mm) entering the range shifter, sigma at thesurface was found to be 10 mm without collimation versus 4 mm with collimation. Additionally, sigma at the surface achievable with collimation was found to be smallerthan for any uncollimated beam, even for very small source beam sizes. Finally, thelateral penumbra achievable with collimation was determined to be largely independentof the source beam size. Conclusion: Collimation can significantly reduce proton pencil beam lateral penumbra.Given the known dosimetric disadvantages resulting from large beam spot sizes,employing a dynamic collimation system can significantly improve lateral tissuesparing in spot-scanned dose distributions.

  6. Proton beam therapy control system

    Science.gov (United States)

    Baumann, Michael A [Riverside, CA; Beloussov, Alexandre V [Bernardino, CA; Bakir, Julide [Alta Loma, CA; Armon, Deganit [Redlands, CA; Olsen, Howard B [Colton, CA; Salem, Dana [Riverside, CA

    2008-07-08

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  7. Defocusing beam line design for an irradiation facility at the TAEA SANAEM Proton Accelerator Facility

    CERN Document Server

    Gencer, A.; Efthymiopoulos, I.; Yiğitoğlu, M.

    2016-01-01

    Electronic components must be tested to ensure reliable performance in high radiation environments such as Hi-Limu LHC and space. We propose a defocusing beam line to perform proton irradiation tests in Turkey. The Turkish Atomic Energy Authority SANAEM Proton Accelerator Facility was inaugurated in May 2012 for radioisotope production. The facility has also an R&D room for research purposes. The accelerator produces protons with 30 MeV kinetic energy and the beam current is variable between View the MathML source10μA and View the MathML source1.2mA. The beam kinetic energy is suitable for irradiation tests, however the beam current is high and therefore the flux must be lowered. We plan to build a defocusing beam line (DBL) in order to enlarge the beam size, reduce the flux to match the required specifications for the irradiation tests. Current design includes the beam transport and the final focusing magnets to blow up the beam. Scattering foils and a collimator is placed for the reduction of the beam ...

  8. Gene Expression Profile of Proton Beam Irradiated Breast Cancer Stem Cells

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Myung Hwan; Park, Jeong Chan [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    Cancer stem cells (CSCs) possess characteristics associated with normal stem cells. The mechanisms regulating CSC radio-resistance, including to proton beam, remain unclear. They showed that a subset of cells expressing CD44 with weak or no CD24 expression could establish new tumors in xenograft mice. Recently, BCSC-targeting therapies have been evaluated by numerous groups. Strategies include targeting BCSC self-renewal, indirectly targeting the microenvironment, and directly killing BCSCs by chemical agents that induce differentiation, immunotherapy, and oncolytic viruses. However, the mechanisms regulating CSC radio-resistance, particularly proton beam resistance, remain unclear. The identification of CSC-related gene expression patterns would make up offer data for better understanding CSCs properties. In this study we investigated the gene expression profile of BCSCs isolation from MCF-7 cell line. Reducing BCSC resistance to pulsed proton beams is essential to improve therapeutic efficacy and decrease the 5-year recurrence rate. In this respect, the information of the level of gene expression patterns in BCSCs is attractive for understanding molecular mechanisms of radio-resistance of BCSCs.

  9. Confinement of a high current proton beam in a linear induction accelerator

    International Nuclear Information System (INIS)

    Kerslick, G.S.; Roth, I.S.; Golkowski, C.; Ivers, J.D.; Nation, J.A.

    1987-01-01

    A 1 MeV, 6 kA, 50 ns annular proton beam has been generated in a two stage induction linac. Several confinement systems designed to allow propagation through multiple acceleration stages have been studied. In the first, the beam is injected through a half cusp into a 1.4 T solenoidal magnetic field. In the second system the beam is generated in a full cusp diode. The third system discussed relies on collective confinement of the protons by the space charge of the neutralizing electrons. This is in contrast to the previously described systems which rely on magnetic confinement. A comparison between the three methods of transport is made

  10. Pitfalls of tungsten multileaf collimator in proton beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Moskvin, Vadim; Cheng, Chee-Wai; Das, Indra J. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202 (United States) and Indiana University Health Proton Therapy Center (Formerly Midwest Proton Radiotherapy Institute), Bloomington, Indiana 47408 (United States)

    2011-12-15

    Purpose: Particle beam therapy is associated with significant startup and operational cost. Multileaf collimator (MLC) provides an attractive option to improve the efficiency and reduce the treatment cost. A direct transfer of the MLC technology from external beam radiation therapy is intuitively straightforward to proton therapy. However, activation, neutron production, and the associated secondary cancer risk in proton beam should be an important consideration which is evaluated. Methods: Monte Carlo simulation with FLUKA particle transport code was applied in this study for a number of treatment models. The authors have performed a detailed study of the neutron generation, ambient dose equivalent [H*(10)], and activation of a typical tungsten MLC and compared with those obtained from a brass aperture used in a typical proton therapy system. Brass aperture and tungsten MLC were modeled by absorber blocks in this study, representing worst-case scenario of a fully closed collimator. Results: With a tungsten MLC, the secondary neutron dose to the patient is at least 1.5 times higher than that from a brass aperture. The H*(10) from a tungsten MLC at 10 cm downstream is about 22.3 mSv/Gy delivered to water phantom by noncollimated 200 MeV beam of 20 cm diameter compared to 14 mSv/Gy for the brass aperture. For a 30-fraction treatment course, the activity per unit volume in brass aperture reaches 5.3 x 10{sup 4} Bq cm{sup -3} at the end of the last treatment. The activity in brass decreases by a factor of 380 after 24 h, additional 6.2 times after 40 days of cooling, and is reduced to background level after 1 yr. Initial activity in tungsten after 30 days of treating 30 patients per day is about 3.4 times higher than in brass that decreases only by a factor of 2 after 40 days and accumulates to 1.2 x 10{sup 6} Bq cm{sup -3} after a full year of operation. The daily utilization of the MLC leads to buildup of activity with time. The overall activity continues to increase

  11. Water equivalence of some plastic-water phantom materials for clinical proton beam dosimetry

    International Nuclear Information System (INIS)

    Al-Sulaiti, L.; Shipley, D.; Thomas, R.; Owen, P.; Kacperek, A.; Regan, P.H.; Palmans, H.

    2012-01-01

    Plastic-water phantom materials are not exactly water equivalent since they have a different elemental composition and different interaction cross sections for protons than water. Several studies of the water equivalence of plastic-water phantom materials have been reported for photon and electron beams, but none for clinical proton beams. In proton beams, the difference between non-elastic nuclear interactions in plastic-water phantom materials compared to those in water should be considered. In this work, the water equivalence of Plastic Water ® (PW) 1 , Plastic Water ® Diagnostic Therapy (PWDT) 1 and solid water (WT1) 2 phantoms was studied for clinical proton energies of 60 MeV and 200 MeV. This was done by evaluating the fluence correction factor at equivalent depths; first with respect to water and then with respect to graphite by experiment and Monte Carlo (MC) simulations using FLUKA. MC simulations showed that the fluence correction with respect to water was less than 0.5% up to the entire penetration depth of the protons at 60 MeV and less than 1% at 200 MeV up to 20 cm depth for PWDT, PW and WT1. With respect to graphite the fluence correction was about 0.5% for 60 MeV and about 4% for 200 MeV. The experimental results for modulated and un-modulated 60 MeV proton beams showed good agreement with the MC simulated fluence correction factors with respect to graphite deviating less than 1% from unity for the three plastic-water phantoms. - Highlights: ► We study plastic-water in clinical proton beams by experiment and Monte Carlo. ► We obtain fluence correction factors for water and graphite. ► The correction factor for water was close to 1 at 60 MeV and <0.990 at 200 MeV. ► The correction factor for graphite was ∼0.5% at 60 MeV and up to 4% at 200 MeV.

  12. Treatment planning, optimization, and beam delivery technqiues for intensity modulated proton therapy

    Science.gov (United States)

    Sengbusch, Evan R.

    Physical properties of proton interactions in matter give them a theoretical advantage over photons in radiation therapy for cancer treatment, but they are seldom used relative to photons. The primary barriers to wider acceptance of proton therapy are the technical feasibility, size, and price of proton therapy systems. Several aspects of the proton therapy landscape are investigated, and new techniques for treatment planning, optimization, and beam delivery are presented. The results of these investigations suggest a means by which proton therapy can be delivered more efficiently, effectively, and to a much larger proportion of eligible patients. An analysis of the existing proton therapy market was performed. Personal interviews with over 30 radiation oncology leaders were conducted with regard to the current and future use of proton therapy. In addition, global proton therapy market projections are presented. The results of these investigations serve as motivation and guidance for the subsequent development of treatment system designs and treatment planning, optimization, and beam delivery methods. A major factor impacting the size and cost of proton treatment systems is the maximum energy of the accelerator. Historically, 250 MeV has been the accepted value, but there is minimal quantitative evidence in the literature that supports this standard. A retrospective study of 100 patients is presented that quantifies the maximum proton kinetic energy requirements for cancer treatment, and the impact of those results with regard to treatment system size, cost, and neutron production is discussed. This study is subsequently expanded to include 100 cranial stereotactic radiosurgery (SRS) patients, and the results are discussed in the context of a proposed dedicated proton SRS treatment system. Finally, novel proton therapy optimization and delivery techniques are presented. Algorithms are developed that optimize treatment plans over beam angle, spot size, spot spacing

  13. Tests of SEC stability in high flux proton beams

    International Nuclear Information System (INIS)

    Agoritsas, V.; Witkover, R.L.

    1979-01-01

    The Secondary Emission Chamber (SEC) is used to measure the beam intensity in slow extracted beam channels of proton synchrotrons around the world. With the improvements in machine intensity, these monitors have been exposed to higher flux conditions than in the past. A change in sensitivity of up to 25% has been observed in the region around the beam spot. Using SEC's of special construction, a series of tests was performed at FNAL, BNL-AGS and CERN-PS. The results of these tests and conclusions about the construction of more stable SEC's are presented

  14. Technical Note: Spot characteristic stability for proton pencil beam scanning.

    Science.gov (United States)

    Chen, Chin-Cheng; Chang, Chang; Moyers, Michael F; Gao, Mingcheng; Mah, Dennis

    2016-02-01

    The spot characteristics for proton pencil beam scanning (PBS) were measured and analyzed over a 16 month period, which included one major site configuration update and six cyclotron interventions. The results provide a reference to establish the quality assurance (QA) frequency and tolerance for proton pencil beam scanning. A simple treatment plan was generated to produce an asymmetric 9-spot pattern distributed throughout a field of 16 × 18 cm for each of 18 proton energies (100.0-226.0 MeV). The delivered fluence distribution in air was measured using a phosphor screen based CCD camera at three planes perpendicular to the beam line axis (x-ray imaging isocenter and up/down stream 15.0 cm). The measured fluence distributions for each energy were analyzed using in-house programs which calculated the spot sizes and positional deviations of the Gaussian shaped spots. Compared to the spot characteristic data installed into the treatment planning system, the 16-month averaged deviations of the measured spot sizes at the isocenter plane were 2.30% and 1.38% in the IEC gantry x and y directions, respectively. The maximum deviation was 12.87% while the minimum deviation was 0.003%, both at the upstream plane. After the collinearity of the proton and x-ray imaging system isocenters was optimized, the positional deviations of the spots were all within 1.5 mm for all three planes. During the site configuration update, spot positions were found to deviate by 6 mm until the tuning parameters file was properly restored. For this beam delivery system, it is recommended to perform a spot size and position check at least monthly and any time after a database update or cyclotron intervention occurs. A spot size deviation tolerance of spot positions were <2 mm at any plane up/down stream 15 cm from the isocenter.

  15. Two-dimensional pencil beam scaling: an improved proton dose algorithm for heterogeneous media

    International Nuclear Information System (INIS)

    Szymanowski, Hanitra; Oelfke, Uwe

    2002-01-01

    New dose delivery techniques with proton beams, such as beam spot scanning or raster scanning, require fast and accurate dose algorithms which can be applied for treatment plan optimization in clinically acceptable timescales. The clinically required accuracy is particularly difficult to achieve for the irradiation of complex, heterogeneous regions of the patient's anatomy. Currently applied fast pencil beam dose calculations based on the standard inhomogeneity correction of pathlength scaling often cannot provide the accuracy required for clinically acceptable dose distributions. This could be achieved with sophisticated Monte Carlo simulations which are still unacceptably time consuming for use as dose engines in optimization calculations. We therefore present a new algorithm for proton dose calculations which aims to resolve the inherent problem between calculation speed and required clinical accuracy. First, a detailed derivation of the new concept, which is based on an additional scaling of the lateral proton fluence is provided. Then, the newly devised two-dimensional (2D) scaling method is tested for various geometries of different phantom materials. These include standard biological tissues such as bone, muscle and fat as well as air. A detailed comparison of the new 2D pencil beam scaling with the current standard pencil beam approach and Monte Carlo simulations, performed with GEANT, is presented. It was found that the new concept proposed allows calculation of absorbed dose with an accuracy almost equal to that achievable with Monte Carlo simulations while requiring only modestly increased calculation times in comparison to the standard pencil beam approach. It is believed that this new proton dose algorithm has the potential to significantly improve the treatment planning outcome for many clinical cases encountered in highly conformal proton therapy. (author)

  16. LHC Abort Gap Filling by Proton Beam

    CERN Document Server

    Fartoukh, Stéphane David; Shaposhnikova, Elena

    2004-01-01

    Safe operation of the LHC beam dump relies on the possibility of firing the abort kicker at any moment during beam operation. One of the necessary conditions for this is that the number of particles in the abort gap should be below some critical level defined by quench limits. Various scenarios can lead to particles filling the abort gap. Time scales associated with these scenarios are estimated for injection energy and also coast where synchrotron radiation losses are not negligible for uncaptured particle motion. Two cases are considered, with RF on and RF off. The equilibrium distribution of lost particles in the abort gap defines the requirements for maximum tolerable relative loss rate and as a consequence the minimum acceptable longitudinal lifetime of the proton beam in collision.

  17. SU-D-BRC-01: An Automatic Beam Model Commissioning Method for Monte Carlo Simulations in Pencil-Beam Scanning Proton Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Qin, N; Shen, C; Tian, Z; Jiang, S; Jia, X [UT Southwestern Medical Ctr, Dallas, TX (United States)

    2016-06-15

    Purpose: Monte Carlo (MC) simulation is typically regarded as the most accurate dose calculation method for proton therapy. Yet for real clinical cases, the overall accuracy also depends on that of the MC beam model. Commissioning a beam model to faithfully represent a real beam requires finely tuning a set of model parameters, which could be tedious given the large number of pencil beams to commmission. This abstract reports an automatic beam-model commissioning method for pencil-beam scanning proton therapy via an optimization approach. Methods: We modeled a real pencil beam with energy and spatial spread following Gaussian distributions. Mean energy, and energy and spatial spread are model parameters. To commission against a real beam, we first performed MC simulations to calculate dose distributions of a set of ideal (monoenergetic, zero-size) pencil beams. Dose distribution for a real pencil beam is hence linear superposition of doses for those ideal pencil beams with weights in the Gaussian form. We formulated the commissioning task as an optimization problem, such that the calculated central axis depth dose and lateral profiles at several depths match corresponding measurements. An iterative algorithm combining conjugate gradient method and parameter fitting was employed to solve the optimization problem. We validated our method in simulation studies. Results: We calculated dose distributions for three real pencil beams with nominal energies 83, 147 and 199 MeV using realistic beam parameters. These data were regarded as measurements and used for commission. After commissioning, average difference in energy and beam spread between determined values and ground truth were 4.6% and 0.2%. With the commissioned model, we recomputed dose. Mean dose differences from measurements were 0.64%, 0.20% and 0.25%. Conclusion: The developed automatic MC beam-model commissioning method for pencil-beam scanning proton therapy can determine beam model parameters with

  18. Dense monoenergetic proton beams from chirped laser-plasma interaction

    Energy Technology Data Exchange (ETDEWEB)

    Galow, Benjamin J.; Keitel, Christoph H. [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, Heidelberg (Germany); Salamin, Yousef I. [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, Heidelberg (Germany); Department of Physics, American University of Sharjah, POB 26666, Sharjah (United Arab Emirates); Liseykina, Tatyana V. [Institut fuer Physik, Universitaet Rostock, 18051 Rostock (Germany); Harman, Zoltan [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, Heidelberg (Germany); ExtreMe Matter Institute EMMI, Planckstrasse 1, 64291 Darmstadt (Germany)

    2012-07-01

    Interaction of a frequency-chirped laser pulse with single protons and a hydrogen gas target is studied analytically and by means of particle-in-cell simulations, respectively. Feasibility of generating ultra-intense (10{sup 7} particles per bunch) and phase-space collimated beams of protons (energy spread of about 1%) is demonstrated. Phase synchronization of the protons and the laser field, guaranteed by the appropriate chirping of the laser pulse, allows the particles to gain sufficient kinetic energy (around 250 MeV) required for such applications as hadron cancer therapy, from state-of-the-art laser systems of intensities of the order of 10{sup 21} W/cm{sup 2}.

  19. Dense monoenergetic proton beams from chirped laser-plasma interaction

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jianxing; Galow, Benjamin J.; Keitel, Christoph H. [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, Heidelberg (Germany); Salamin, Yousef I. [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, Heidelberg (Germany); Department of Physics, American University of Sharjah, POB 26666, Sharjah (United Arab Emirates); Harman, Zoltan [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, Heidelberg (Germany); ExtreMe Matter Institute EMMI, Planckstrasse 1, 64291 Darmstadt (Germany)

    2013-07-01

    Interactions of linearly and radially polarized frequency-chirped laser pulses with single protons and hydrogen gas targets are studied analytically and by means of particle-in-cell simulations, respectively. The feasibility of generating ultra-intense (10{sup 7} particles per bunch) and phase-space collimated beams of protons is demonstrated. Phase synchronization of the protons and the laser field, guaranteed by the appropriate chirping of the laser pulse, allows the particles to gain sufficient kinetic energy (around 250 MeV) required for such applications as hadron cancer therapy, from state-of-the-art laser systems of intensities of the order of 10{sup 21} W/cm{sup 2}.

  20. Suitability of some common polymer films for MeV proton beam dosimetry

    International Nuclear Information System (INIS)

    Makkonen-Craig, S.; Paronen, M.; Arstila, K.; Helariutta, K.; Rauhala, E.; Tikkanen, P.

    2005-01-01

    We have been evaluating the efficacy of polymer films for proton beam dosimetry. PE, PS, PVF, PVDF, PFA and FEP films were irradiated with 4.1 and 9.4 MeV protons at a flux of 2.5 x 10 11 cm -2 s -1 and a fluence of 2.5 x 10 13 cm -2 . The perfluorinated films were relatively insensitive to the proton irradiation. The UV absorption of PS displayed significant radiation-induced red shift, but no quantifiable absorption peaks. The strongly absorbing chromophore at 225 nm of irradiated PVDF is too unstable for practical dosimetry. PE has a stable and moderately absorbing radiolytic chromophore at 235 nm, but is transparent in the visible wavelength region. Irradiated PVF absorbs strongly in both UV and visible regions, and its UV absorbance is linearly proportional to the dose over the range of 10-1000 kGy when irradiated with 4.1 MeV protons at a dose rate of 840 Gy s -1 . PVF shows the most potential as multipurpose dosimeter for high resolution profiling of ion beams. Pertinent applications include irradiations that require verification of lateral beam homogeneity

  1. Analysis of target implosion irradiated by proton beam, (1)

    International Nuclear Information System (INIS)

    Tamba, Moritake; Nagata, Norimasa; Kawata, Shigeo; Niu, Keishiro.

    1982-10-01

    Numerical simulation and analysis were performed for the implosion of a hollow shell target driven by proton beam. The target consists of three layers of Pb, Al and DT. As the Al layer is heated by proton beam, the layer expands and pushes the DT layer toward the target center. To obtain the optimal velocity of DT implosion, the optimal target size and optimal layer thickness were determined. The target size is determined by, for example, the instability of the implosion or beam focusing on the target surface. The Rayleigh-Taylor instability and the unstable implosion due to the inhomogeneity were investigated. Dissipation, nonlinear effects and density gradient at the boundary were expected to reduce the growth rate of the Rayleigh-Taylor instability during the implosion. In order that the deviation of the boundary surface during the implosion is less than the thickness of fuel, the inhomogeneity of the temperature and the density of the target should be less than ten percent. The amplitude of the boundary surface roughness is required to be less than 4 micrometer. (Kato, T.)

  2. The effect of anterior proton beams in the setting of a prostate-rectum spacer

    Energy Technology Data Exchange (ETDEWEB)

    Christodouleas, John P., E-mail: christojo@uphs.upenn.edu [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA (United States); Tang, Shikui [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA (United States); Susil, Robert C.; McNutt, Todd R.; Song, Danny Y. [Department of Radiation Oncology and Radiation Molecular Sciences, Johns Hopkins Hospital, Baltimore, MD (United States); Bekelman, Justin; Deville, Curtiland; Vapiwala, Neha [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA (United States); DeWeese, Theodore L. [Department of Radiation Oncology and Radiation Molecular Sciences, Johns Hopkins Hospital, Baltimore, MD (United States); Lu, Hsiao-Ming [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Both, Stefan [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA (United States)

    2013-10-01

    Studies suggest that anterior beams with in vivo range verification would improve rectal dosimetry in proton therapy for prostate cancer. We investigated whether prostate-rectum spacers would enhance or diminish the benefits of anterior proton beams in these treatments. Twenty milliliters of hydrogel was injected between the prostate and rectum of a cadaver using a transperineal approach. Computed tomography (CT) and magnetic resonance (MR) images were used to generate 7 uniform scanning (US) and 7 single-field uniform dose pencil-beam scanning (PBS) plans with different beam arrangements. Pearson correlations were calculated between rectal, bladder, and femoral head dosimetric outcomes and beam arrangement anterior scores, which characterize the degree to which dose is delivered anteriorly. The overall quality of each plan was compared using a virtual dose-escalation study. For US plans, rectal mean dose was inversely correlated with anterior score, but for PBS plans there was no association between rectal mean dose and anterior score. For both US and PBS plans, full bladder and empty bladder mean doses were correlated with anterior scores. For both US and PBS plans, femoral head mean doses were inversely correlated with anterior score. For US plans and a full bladder, 4 beam arrangements that included an anterior beam tied for the highest maximum prescription dose (MPD). For US plans and an empty bladder, the arrangement with 1 anterior and 2 anterior oblique beams achieved the highest MPD in the virtual dose-escalation study. The dose-escalation study did not differentiate beam arrangements for PBS. All arrangements in the dose-escalation study were limited by bladder constraints except for the arrangement with 2 posterior oblique beams. The benefits of anterior proton beams in the setting of prostate-rectum spacers appear to be proton modality dependent and may not extend to PBS.

  3. The effect of anterior proton beams in the setting of a prostate-rectum spacer

    Science.gov (United States)

    Christodouleas, John P.; Tang, Shikui; Susil, Robert C.; McNutt, Todd R.; Song, Danny Y.; Bekelman, Justin; Deville, Curtiland; Vapiwala, Neha; DeWeese, Theodore L.; Lu, Hsiao-Ming; Both, Stefan

    2014-01-01

    Studies suggest that anterior beams with in vivo range verification would improve rectal dosimetry in proton therapy for prostate cancer. We investigated whether prostate-rectum spacers would enhance or diminish the benefits of anterior proton beams in these treatments. Twenty milliliters of hydrogel was injected between the prostate and rectum of a cadaver using a transperineal approach. Computed tomography (CT) and magnetic resonance (MR) images were used to generate 7 uniform scanning (US) and 7 single-field uniform dose pencil-beam scanning (PBS) plans with different beam arrangements. Pearson correlations were calculated between rectal, bladder, and femoral head dosimetric outcomes and beam arrangement anterior scores, which characterize the degree to which dose is delivered anteriorly. The overall quality of each plan was compared using a virtual dose-escalation study. For US plans, rectal mean dose was inversely correlated with anterior score, but for PBS plans there was no association between rectal mean dose and anterior score. For both US and PBS plans, full bladder and empty bladder mean doses were correlated with anterior scores. For both US and PBS plans, femoral head mean doses were inversely correlated with anterior score. For US plans and a full bladder, 4 beam arrangements that included an anterior beam tied for the highest maximum prescription dose (MPD). For US plans and an empty bladder, the arrangement with 1 anterior and 2 anterior oblique beams achieved the highest MPD in the virtual dose-escalation study. The dose-escalation study did not differentiate beam arrangements for PBS. All arrangements in the dose-escalation study were limited by bladder constraints except for the arrangement with 2 posterior oblique beams. The benefits of anterior proton beams in the setting of prostate-rectum spacers appear to be proton modality dependent and may not extend to PBS. PMID:23578497

  4. Efficient production and diagnostics of MeV proton beams from a cryogenic hydrogen ribbon

    International Nuclear Information System (INIS)

    Velyhan, A.; Giuffrida, L.; Scuderi, V.; Lastovicka, T.; Margarone, D.; Perin, J.P.; Chatain, D.; Garcia, S.; Bonnay, P.; Dostal, J.; Ullschmied, J.; Dudzak, R.; Krousky, E.; Cykhardt, J.; Prokupek, J.; Pfeifer, M.; Rosinski, M.; Krasa, J.; Brabcova, K.; Napoli, M. De

    2017-01-01

    A solid hydrogen thin ribbon, produced by the cryogenic system ELISE (Experiments on Laser Interaction with Solid hydrogEn) target delivery system, was experimentally used at the PALS kJ-laser facility to generate intense proton beams with energies in the MeV range. This sophisticated target system operating at cryogenic temperature (∼ 10 K) continuously producing a 62 μm thick target was combined with a 600 J sub-nanosecond laser pulse to generate a collimated proton stream. The accelerated proton beams were fully characterized by a number of diagnostics. High conversion efficiency of laser to energetic protons is of great interest for future potential applications in non-conventional proton therapy and fast ignition for inertial confinement fusion.

  5. Benchmark measurements and simulations of dose perturbations due to metallic spheres in proton beams

    International Nuclear Information System (INIS)

    Newhauser, Wayne D.; Rechner, Laura; Mirkovic, Dragan; Yepes, Pablo; Koch, Nicholas C.; Titt, Uwe; Fontenot, Jonas D.; Zhang, Rui

    2013-01-01

    Monte Carlo simulations are increasingly used for dose calculations in proton therapy due to its inherent accuracy. However, dosimetric deviations have been found using Monte Carlo code when high density materials are present in the proton beamline. The purpose of this work was to quantify the magnitude of dose perturbation caused by metal objects. We did this by comparing measurements and Monte Carlo predictions of dose perturbations caused by the presence of small metal spheres in several clinical proton therapy beams as functions of proton beam range and drift space. Monte Carlo codes MCNPX, GEANT4 and Fast Dose Calculator (FDC) were used. Generally good agreement was found between measurements and Monte Carlo predictions, with the average difference within 5% and maximum difference within 17%. The modification of multiple Coulomb scattering model in MCNPX code yielded improvement in accuracy and provided the best overall agreement with measurements. Our results confirmed that Monte Carlo codes are well suited for predicting multiple Coulomb scattering in proton therapy beams when short drift spaces are involved. - Highlights: • We compared measurements and Monte Carlo predictions of dose perturbations caused by the metal objects in proton beams. • Different Monte Carlo codes were used, including MCNPX, GEANT4 and Fast Dose Calculator. • Good agreement was found between measurements and Monte Carlo simulations. • The modification of multiple Coulomb scattering model in MCNPX code yielded improved accuracy. • Our results confirmed that Monte Carlo codes are well suited for predicting multiple Coulomb scattering in proton therapy

  6. Polarized proton and deuteron targets for the usage in intensive proton beams

    International Nuclear Information System (INIS)

    Get'man, V.A.; Derkach, A.Ya.; Karnaukhov, I.M.; Lukhanin, A.A.; Razumnyj, A.A.; Sorokin, P.V.; Sporo, E.A.; Telegin, Yu.N.

    1982-01-01

    Polarized proton and deuteron targets are developed and tested for conducting investigations in intense photon beams. A flowsheet of polarization targets which includes: working agent of the target, superconducting magnet, cryostat of 3 He evaporation with 3 He pumping and recirculation systems, SHF system of 4 mm range for polarization pumping, measuring system of target polarization protons is presented. Working agent of the targets includes frozen balls with 1.5 mm diameter. Ethylene-glucol and 1.2-propylene-glycol were used as a working substance for proton targets. Completely deuterated ethylene-glycol was used for the deuteron target. Vertical magnetic field with 2.7 T intensity is produced by a superconducting magnetic system. Polarization pumping is exercised at 75 GHz frequency. Q-meter of direct current is used for determination of polarization. Working temperature of the cryostat is approximately 0.5 K. The lock device permits to exercise replacement of the target working agent during 30 minutes

  7. Numerical Studies of Electron Acceleration Behind Self-Modulating Proton Beam in Plasma with a Density Gradient

    CERN Document Server

    Petrenko, A.; Sosedkin, A.

    2016-01-01

    Presently available high-energy proton beams in circular accelerators carry enough momentum to accelerate high-intensity electron and positron beams to the TeV energy scale over several hundred meters of the plasma with a density of about 1e15 1/cm^3. However, the plasma wavelength at this density is 100-1000 times shorter than the typical longitudinal size of the high-energy proton beam. Therefore the self-modulation instability (SMI) of a long (~10 cm) proton beam in the plasma should be used to create the train of micro-bunches which would then drive the plasma wake resonantly. Changing the plasma density profile offers a simple way to control the development of the SMI and the acceleration of particles during this process. We present simulations of the possible use of a plasma density gradient as a way to control the acceleration of the electron beam during the development of the SMI of a 400 GeV proton beam in a 10 m long plasma. This work is done in the context of the AWAKE project --- the proof-of-prin...

  8. Technical Note: Using experimentally determined proton spot scanning timing parameters to accurately model beam delivery time.

    Science.gov (United States)

    Shen, Jiajian; Tryggestad, Erik; Younkin, James E; Keole, Sameer R; Furutani, Keith M; Kang, Yixiu; Herman, Michael G; Bues, Martin

    2017-10-01

    To accurately model the beam delivery time (BDT) for a synchrotron-based proton spot scanning system using experimentally determined beam parameters. A model to simulate the proton spot delivery sequences was constructed, and BDT was calculated by summing times for layer switch, spot switch, and spot delivery. Test plans were designed to isolate and quantify the relevant beam parameters in the operation cycle of the proton beam therapy delivery system. These parameters included the layer switch time, magnet preparation and verification time, average beam scanning speeds in x- and y-directions, proton spill rate, and maximum charge and maximum extraction time for each spill. The experimentally determined parameters, as well as the nominal values initially provided by the vendor, served as inputs to the model to predict BDTs for 602 clinical proton beam deliveries. The calculated BDTs (T BDT ) were compared with the BDTs recorded in the treatment delivery log files (T Log ): ∆t = T Log -T BDT . The experimentally determined average layer switch time for all 97 energies was 1.91 s (ranging from 1.9 to 2.0 s for beam energies from 71.3 to 228.8 MeV), average magnet preparation and verification time was 1.93 ms, the average scanning speeds were 5.9 m/s in x-direction and 19.3 m/s in y-direction, the proton spill rate was 8.7 MU/s, and the maximum proton charge available for one acceleration is 2.0 ± 0.4 nC. Some of the measured parameters differed from the nominal values provided by the vendor. The calculated BDTs using experimentally determined parameters matched the recorded BDTs of 602 beam deliveries (∆t = -0.49 ± 1.44 s), which were significantly more accurate than BDTs calculated using nominal timing parameters (∆t = -7.48 ± 6.97 s). An accurate model for BDT prediction was achieved by using the experimentally determined proton beam therapy delivery parameters, which may be useful in modeling the interplay effect and patient throughput. The model may

  9. SU-E-T-665: Radiochromic Film Quenching Effect Reduction for Proton Beam Dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Aldelaijan, S; Alzorkany, F; Moftah, B; Alrumayan, F [King Faisal Specialist Hospital & Research Centre, Riyadh (Saudi Arabia); Seuntjens, J [McGill University, Montreal, QC (Canada); Lewis, D [RCF Consulting, LLC, Monroe, CT (United States); Devic, S [McGill University, Montreal, QC (Canada); Jewish General Hospital, Montreal, QC (Canada)

    2015-06-15

    Purpose: Depending on the useful dose range in which radiochromic films operate, number of different radiochromic film models have been designed. The impact of different film models on quenching effect for percent depth dose (PDD) measurements in proton beams has been investigated. Methods: Calibrated PTW Markus ionization chamber was used to measure PDD and beam output for 26.5 MeV protons produced by CS30 cyclotron. An aluminum cylinder was added in front of the beam exit serving as a radiation shutter. The measured signal was normalized to a monitor chamber reading and subsequently scaled by ratio of water-to-air stopping powers at given depth, while the effective depth of measurements was scaled by ratios of material-to-water physical densities and CSDA ranges. Output was measured in water at 2.1 mm reference-depth in the plateau upstream from the Bragg peak. Following the TRS-398 reference dosimetry protocol for proton beams, the output was calibrated in water. Three radiochromic film models (EBT, EBT3 and HD-V2) were calibrated within Lexan phantom positioned at the same water-equivalent depth. Thicknesses of films sensitive layers were 34 µm, 30 µm and 8 µm, respectively. Small film pieces (1 x 2 cm{sup 2}) were positioned within polyethylene phantom along the beam central axis with an angulation of 5° for PDD measurements. Results: While the output of the proton beam was found to be around 7 Gy/sec, the actual value of the output per monitor chamber reading (2.32 Gy/nC) was used for reference-dose irradiations during film calibration. Dose ratios at the Bragg peak relative to the reference-depth were 3.88, 2.52, 2.19, and 2.02 for the Markus chamber, HD-V2, EBT3, and EBT film models, respectively. Conclusion: Results at hand suggest that quenching effect is reduced when a radiochromic film model with smaller sensitive layer thickness is used for PDD measurements in proton beams. David Lewis is the owner of RCF Consulting, LLC.

  10. SU-E-J-49: Distal Edge Activity Fall Off Of Proton Therapy Beams

    Energy Technology Data Exchange (ETDEWEB)

    Elmekawy, A; Ewell, L [Hampton University, Hampton, VA (United States); Butuceanu, C; Zhu, L [HUPTI, Hampton, VA (United States)

    2014-06-01

    Purpose: To characterize and quantify the distal edge activity fall off, created in a phantom by a proton therapy beam Method and Materials: A 30x30x10cm polymethylmethacrylate phantom was irradiated with a proton therapy beam using different ranges and beams. The irradiation volume is approximated by a right circular cylinder of diameter 7.6cm and varying lengths. After irradiation, the phantom was scanned via a Philips Gemini Big Bore™ PET-CT for isotope activation. Varian Eclipse™ treatment planning system as well as ImageJ™ were used to analyze the resulting PET and CT scans. The region of activity within the phantom was longitudinally measured as a function of PET slice number. Dose estimations were made via Monte Carlo (GATE) simulation. Results: For both the spread out Bragg peak (SOBP) and the mono-energetic pristine Bragg peak proton beams, the proximal activation rise was steep: average slope −0.735 (average intensity/slice number) ± 0.091 (standard deviation) for the pristine beams and −1.149 ± 0.117 for the SOBP beams. In contrast, the distal fall offs were dissimilar. The distal fall off in activity for the pristine beams was fit well by a linear curve: R{sup 2} (Pierson Product) was 0.9968, 0.9955 and 0.9909 for the 13.5, 17.0 and 21.0cm range beams respectively. The good fit allows for a slope comparison between the different ranges. The slope varied as a function of range from 1.021 for the 13.5cm beam to 0.8407 (average intensity/slice number) for the 21.0cm beam. This dependence can be characterized: −0.0234(average intensity/slice number/cm range). For the SOBP beams, the slopes were significantly less and were also less linear: average slope 0.2628 ± 0.0474, average R{sup 2}=0.9236. Conclusion: The distal activation fall off edge for pristine proton beams was linear and steep. The corresponding quantities for SOBP beams were shallower and less linear. Philips has provided support for this work.

  11. Beam optics on the Melbourne proton microprobe

    International Nuclear Information System (INIS)

    Jamieson, D.N.; Colman, R.A.; Allan, G.L.; Legge, G.J.F.

    1985-01-01

    This review paper summarises results of ion optics development work conducted on the Melbourne Proton Microprobe and the associated Pelletron accelerator. The properties of a field ionization ion source have been investigated with the aim of replacing the existing R.F. ion source in the accelerator in order to obtain a brighter beam for the microprobe. The electrostatic emitter lens in the terminal of the accelerator has also been investigated with the aim of improving the focus of the accelerated beam. Finally, the aberrations of the probe forming lens system have been studied and it is shown how some of these may be corrected with an octupole lens

  12. Dark Matter Search in a Proton Beam Dump with MiniBooNE.

    Science.gov (United States)

    Aguilar-Arevalo, A A; Backfish, M; Bashyal, A; Batell, B; Brown, B C; Carr, R; Chatterjee, A; Cooper, R L; deNiverville, P; Dharmapalan, R; Djurcic, Z; Ford, R; Garcia, F G; Garvey, G T; Grange, J; Green, J A; Huelsnitz, W; de Icaza Astiz, I L; Karagiorgi, G; Katori, T; Ketchum, W; Kobilarcik, T; Liu, Q; Louis, W C; Marsh, W; Moore, C D; Mills, G B; Mirabal, J; Nienaber, P; Pavlovic, Z; Perevalov, D; Ray, H; Roe, B P; Shaevitz, M H; Shahsavarani, S; Stancu, I; Tayloe, R; Taylor, C; Thornton, R T; Van de Water, R; Wester, W; White, D H; Yu, J

    2017-06-02

    The MiniBooNE-DM Collaboration searched for vector-boson mediated production of dark matter using the Fermilab 8-GeV Booster proton beam in a dedicated run with 1.86×10^{20} protons delivered to a steel beam dump. The MiniBooNE detector, 490 m downstream, is sensitive to dark matter via elastic scattering with nucleons in the detector mineral oil. Analysis methods developed for previous MiniBooNE scattering results were employed, and several constraining data sets were simultaneously analyzed to minimize systematic errors from neutrino flux and interaction rates. No excess of events over background was observed, leading to a 90% confidence limit on the dark matter cross section parameter, Y=ε^{2}α_{D}(m_{χ}/m_{V})^{4}≲10^{-8}, for α_{D}=0.5 and for dark matter masses of 0.01dark matter. This is the best limit from a dedicated proton beam dump search in this mass and coupling range and extends below the mass range of direct dark matter searches. These results demonstrate a novel and powerful approach to dark matter searches with beam dump experiments.

  13. Development of linear proton accelerators with the high average beam power

    CERN Document Server

    Bomko, V A; Egorov, A M

    2001-01-01

    Review of the current situation in the development of powerful linear proton accelerators carried out in many countries is given. The purpose of their creation is solving problems of safe and efficient nuclear energetics on a basis of the accelerator-reactor complex. In this case a proton beam with the energy up to 1 GeV, the average current of 30 mA is required. At the same time there is a needed in more powerful beams,for example, for production of tritium and transmutation of nuclear waste products. The creation of accelerators of such a power will be followed by the construction of linear accelerators of 1 GeV but with a more moderate beam current. They are intended for investigation of many aspects of neutron physics and neutron engineering. Problems in the creation of efficient constructions for the basic and auxiliary equipment, the reliability of the systems, and minimization of the beam losses in the process of acceleration will be solved.

  14. Structure modification and medical application of the natural products by proton beam irradiation

    International Nuclear Information System (INIS)

    Lee, D. W.; Park, J. K.; Kang, J. E.; Shin, S. C.; Ahn, J. H.; Lee, E. S.

    2008-04-01

    This study was performed for the investigation of changes of constituent contents of Korean ginseng (Panax genseng C.A. Meyer) after proton beam irradiation (Beam energy from MC-50 cyclotron : 36.5MeV) with beam range of 500 - 10000Gy

  15. Structure modification and medical application of the natural products by proton beam irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, D. W.; Park, J. K.; Kang, J. E.; Shin, S. C.; Ahn, J. H.; Lee, E. S. [Dongguk University, Gyeongju (Korea, Republic of)

    2008-04-15

    This study was performed for the investigation of changes of constituent contents of Korean ginseng (Panax genseng C.A. Meyer) after proton beam irradiation (Beam energy from MC-50 cyclotron : 36.5MeV) with beam range of 500 - 10000Gy

  16. The potential of proton beam radiation therapy in lung cancer (including mesothelioma)

    Energy Technology Data Exchange (ETDEWEB)

    Bjelkengren, Goeran [Univ. Hospital, Malmoe (Sweden). Dept. of Oncology; Glimelius, Bengt [Karolinska Inst., Stockholm (Sweden). Dept. of Oncology and Pathology; Akademiska sjukhuset, Uppsala (Sweden). Dept. of Oncology, Radiology and Clinical Immunology

    2005-12-01

    A Swedish group of oncologists and hospital physicists have estimated the number of patients in Sweden suitable for proton beam therapy. The estimations have been based on current statistics of tumour incidence, number of patients potentially eligible for radiation treatment, scientific support from clinical trials and model dose planning studies and knowledge of the dose-response relations of different tumours and normal tissues. It is estimated that about 350 patients with lung cancer and about 20 patients with mesothelioma annually may benefit from proton beam therapy.

  17. A hospital-based proton linac for neutron therapy and radioisotope production

    International Nuclear Information System (INIS)

    Lennox, A.J.

    1988-10-01

    Fermilab's Alvarez proton linac has been used routinely for neutron therapy since 1976. The Neutron Therapy Facility (NTF) operates in a mode parasitic to the laboratory's high energy physics program, which uses the linac as an injector for a synchrotron. Parasitic operation is possible because the linac delivers /approximately/1.2 /times/ 10 13 protons per pulse at a 15 Hz rate, while the high energy physics program requires beam at a rate not greater than 0.5 Hz. Protons not needed for physics experiments strike a beryllium target to produce neutrons for neutron therapy. Encouraging clinical results from NTF have led to a study of the issues involved in providing hospitals with a neutron beam of the type available at Fermilab. This paper describes the issues addressed by that study. 12 refs., 1 fig., 1 tab

  18. Development of over-production strain of saccharification enzyme and biomass pretreatment by proton beam irradiation

    International Nuclear Information System (INIS)

    Kim, S. O.; Lee, J. Y.; Song, Y. S.; Shin, H. S.

    2009-04-01

    - The first year : Pre-treatment of biomass by proton beam irradiation and characterization of the pretreated biomass by IR and SEM - The second year : Strain development by proton beam irradiation for the production of cellulase and hemicellulase - The third year : Optimization of Saccharification process by cellulase and hemicellulase

  19. Beam tube vacuum in future superconducting proton colliders

    International Nuclear Information System (INIS)

    Turner, W.

    1994-10-01

    The beam tube vacuum requirements in future superconducting proton colliders that have been proposed or discussed in the literature -- SSC, LHC, and ELN -- are reviewed. The main beam tube vacuum problem encountered in these machines is how to deal with the magnitude of gas desorption and power deposition by synchrotron radiation while satisfying resistivity, impedance, and space constraints in the cryogenic environment of superconducting magnets. A beam tube vacuum model is developed that treats photodesorption of tightly bound H, C, and 0, photodesorption of physisorbed molecules, and the isotherm vapor pressure of H 2 . Experimental data on cold tube photodesorption experiments are reviewed and applied to model calculations of beam tube vacuum performance for simple cold beam tube and liner configurations. Particular emphasis is placed on the modeling and interpretation of beam tube photodesorpiion experiments at electron synchrotron light sources. The paper also includes discussion of the constraints imposed by beam image current heating, the growth rate of the resistive wall instability, and single-bunch instability impedance limits

  20. Impact of high energy high intensity proton beams on targets: Case studies for Super Proton Synchrotron and Large Hadron Collider

    CERN Document Server

    Tahir, N A; Shutov, A; Schmidt, R; Piriz, A R

    2012-01-01

    The Large Hadron Collider (LHC) is designed to collide two proton beams with unprecedented particle energy of 7 TeV. Each beam comprises 2808 bunches and the separation between two neighboring bunches is 25 ns. The energy stored in each beam is 362 MJ, sufficient to melt 500 kg copper. Safety of operation is very important when working with such powerful beams. An accidental release of even a very small fraction of the beam energy can result in severe damage to the equipment. The machine protection system is essential to handle all types of possible accidental hazards; however, it is important to know about possible consequences of failures. One of the critical failure scenarios is when the entire beam is lost at a single point. In this paper we present detailed numerical simulations of the full impact of one LHC beam on a cylindrical solid carbon target. First, the energy deposition by the protons is calculated with the FLUKA code and this energy deposition is used in the BIG2 code to study the corresponding...

  1. High-Efficiency Volume Reflection of an Ultrarelativistic Proton Beam with a Bent Silicon Crystal

    CERN Document Server

    Scandale, Walter; Carnera, Alberto; Della Mea, Gianantonio; De Salvador, Davide; Milan, Riccardo; Vomiero, Alberto; Baricordi, Stefano; Dalpiaz, Pietro; Fiorini, Massimiliano; Guidi, Vincenzo; Martinelli,Giuliano; Mazzolari, Andrea; Milan, Emiliano; Ambrosi, Giovanni; Azzarello, Philipp; Battiston, Roberto; Bertucci, Bruna; Burger, William J; Ionica, Maria; Zuccon, Paolo; Cavoto, Gianluca; Santacesaria, Roberta; Valente, Paolo; Vallazza, Erik; Afonin, Alexander G; Baranov, Vladimir T; Chesnokov, Yury A; Kotov, Vladilen I; Maisheev, Vladimir A; Yaznin, Igor A; Afansiev, Sergey V; Kovalenko, Alexander D; Taratin, Alexander M; Denisov, Alexander S; Gavrikov, Yury A; Ivanov, Yuri M; Ivochkin, Vladimir G; Kosyanenko, Sergey V; Petrunin, Anatoli A; Skorobogatov, Vyacheslav V; Suvorov, Vsevolod M; Bolognini, Davide; Foggetta,Luca; Hasan, Said; Prest, Michela

    2007-01-01

    The volume reflection phenomenon was detected while investigating 400 GeV proton interactions with bent silicon crystals in the external beam H8 of the CERN Super Proton Synchrotron. Such a process was observed for a wide interval of crystal orientations relative to the beam axis, and its efficiency exceeds 95%, thereby surpassing any previously observed value. These observations suggest new perspectives for the manipulation of high-energy beams, e.g., for collimation and extraction in new-generation hadron colliders, such as the CERN Large Hadron Collider.

  2. Proton beam stereotactic radiosurgery of vestibular schwannomas

    International Nuclear Information System (INIS)

    Harsh, Griffith R.; Thornton, Allan F.; Chapman, Paul H.; Bussiere, Marc R.; Rabinov, James D.; Loeffler, Jay S.

    2002-01-01

    Purpose: The proton beam's Bragg peak permits highly conformal radiation of skull base tumors. This study, prompted by reports of transient (30% each) and permanent (10% each) facial and trigeminal neuropathy after stereotactic radiosurgery of vestibular schwannomas with marginal doses of 16-20 Gy, assessed whether proton beam radiosurgery using a marginal dose of only 12 Gy could control vestibular schwannomas while causing less neuropathy. Methods and Materials: Sixty-eight patients (mean age 67 years) were treated between 1992 and 1998. The mean tumor volume was 2.49 cm 3 . The dose to the tumor margin (70% isodose line) was 12 Gy. The prospectively specified follow-up consisted of neurologic evaluation and MRI at 6, 12, 24, and 36 months. Results: After a mean clinical follow-up of 44 months and imaging follow-up of 34 months in 64 patients, 35 tumors (54.7%) were smaller and 25 (39.1%) were unchanged (tumor control rate 94%; actuarial control rate 94% at 2 years and 84% at 5 years). Three tumors enlarged: one shrank after repeated radiosurgery, one remained enlarged at the time of unrelated death, and one had not been imaged for 4 years in a patient who remained asymptomatic at last follow-up. Intratumoral hemorrhage into one stable tumor required craniotomy that proved successful. Thus, 97% of tumors required no additional treatment. Three patients (4.7%) underwent shunting for hydrocephalus evident as increased ataxia. Of 6 patients with functional hearing ipsilaterally, 1 improved, 1 was unchanged, and 4 progressively lost hearing. Cranial neuropathies were infrequent: persistent facial hypesthesia (2 new, 1 exacerbated; 4.7%); intermittent facial paresthesias (5 new, 1 exacerbated; 9.4%); persistent facial weakness (2 new, 1 exacerbated; 4.7%) requiring oculoplasty; transient partial facial weakness (5 new, 1 exacerbated; 9.4%), and synkinesis (5 new, 1 exacerbated; 9.4%). Conclusion: Proton beam stereotactic radiosurgery of vestibular schwannomas at the

  3. Improved spectral data unfolding for radiochromic film imaging spectroscopy of laser-accelerated proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Schollmeier, M.; Geissel, M.; Sefkow, A. B. [Sandia National Laboratories, Albuquerque, New Mexico 87185 (United States); Flippo, K. A. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)

    2014-04-15

    An improved method to unfold the space-resolved proton energy distribution function of laser-accelerated proton beams using a layered, radiochromic film (RCF) detector stack has been developed. The method takes into account the reduced RCF response near the Bragg peak due to a high linear energy transfer (LET). This LET dependence of the active RCF layer has been measured, and published data have been re-interpreted to find a nonlinear saturation scaling of the RCF response with stopping power. Accounting for the LET effect increased the integrated particle yield by 25% after data unfolding. An iterative, analytical, space-resolved deconvolution of the RCF response functions from the measured dose was developed that does not rely on fitting. After the particle number unfold, three-dimensional interpolation is performed to determine the spatial proton beam distribution for proton energies in-between the RCF data points. Here, image morphing has been implemented as a novel interpolation method that takes into account the energy-dependent, changing beam topology.

  4. A Fourier analysis on the maximum acceptable grid size for discrete proton beam dose calculation

    International Nuclear Information System (INIS)

    Li, Haisen S.; Romeijn, H. Edwin; Dempsey, James F.

    2006-01-01

    We developed an analytical method for determining the maximum acceptable grid size for discrete dose calculation in proton therapy treatment plan optimization, so that the accuracy of the optimized dose distribution is guaranteed in the phase of dose sampling and the superfluous computational work is avoided. The accuracy of dose sampling was judged by the criterion that the continuous dose distribution could be reconstructed from the discrete dose within a 2% error limit. To keep the error caused by the discrete dose sampling under a 2% limit, the dose grid size cannot exceed a maximum acceptable value. The method was based on Fourier analysis and the Shannon-Nyquist sampling theorem as an extension of our previous analysis for photon beam intensity modulated radiation therapy [J. F. Dempsey, H. E. Romeijn, J. G. Li, D. A. Low, and J. R. Palta, Med. Phys. 32, 380-388 (2005)]. The proton beam model used for the analysis was a near mono-energetic (of width about 1% the incident energy) and monodirectional infinitesimal (nonintegrated) pencil beam in water medium. By monodirection, we mean that the proton particles are in the same direction before entering the water medium and the various scattering prior to entrance to water is not taken into account. In intensity modulated proton therapy, the elementary intensity modulation entity for proton therapy is either an infinitesimal or finite sized beamlet. Since a finite sized beamlet is the superposition of infinitesimal pencil beams, the result of the maximum acceptable grid size obtained with infinitesimal pencil beam also applies to finite sized beamlet. The analytic Bragg curve function proposed by Bortfeld [T. Bortfeld, Med. Phys. 24, 2024-2033 (1997)] was employed. The lateral profile was approximated by a depth dependent Gaussian distribution. The model included the spreads of the Bragg peak and the lateral profiles due to multiple Coulomb scattering. The dependence of the maximum acceptable dose grid size on the

  5. Water equivalent thickness values of materials used in beams of protons, helium, carbon and iron ions.

    Science.gov (United States)

    Zhang, Rui; Taddei, Phillip J; Fitzek, Markus M; Newhauser, Wayne D

    2010-05-07

    Heavy charged particle beam radiotherapy for cancer is of increasing interest because it delivers a highly conformal radiation dose to the target volume. Accurate knowledge of the range of a heavy charged particle beam after it penetrates a patient's body or other materials in the beam line is very important and is usually stated in terms of the water equivalent thickness (WET). However, methods of calculating WET for heavy charged particle beams are lacking. Our objective was to test several simple analytical formulas previously developed for proton beams for their ability to calculate WET values for materials exposed to beams of protons, helium, carbon and iron ions. Experimentally measured heavy charged particle beam ranges and WET values from an iterative numerical method were compared with the WET values calculated by the analytical formulas. In most cases, the deviations were within 1 mm. We conclude that the analytical formulas originally developed for proton beams can also be used to calculate WET values for helium, carbon and iron ion beams with good accuracy.

  6. Focused proton beams propagating in reactor of fusion power plant

    Energy Technology Data Exchange (ETDEWEB)

    Niu, K [Teikyo Heisei Univ., Uruido, Ichihara, Chiba (Japan)

    1997-12-31

    One of the difficult tasks of light ion beam fusion is to propagate the beam in the reactor cavity and to focus the beam on the target. The light ion beam has a certain local divergence angle because there are several causes for divergence at the diode. The electrostatic force induced at the leading edge causes beam divergence during propagation. To confine the beam within a small radius during propagation, the magnetic field must be employed. Here the electron beam is proposed to be launched simultaneously with the launching of the proton beam. If the electron beam has the excess current, the beam induces a magnetic field in the negative azimuthal direction, which confines the ion beam within a small radius by the electrostatic field as well as the electron beam by the Lorentz force. The metal guide around the beam path helps the beam confinement and reduces the total amount of magnetic field energy induced by the electron current. (author). 2 figs., 15 refs.

  7. A light-weight compact proton gantry design with a novel dose delivery system for broad-energetic laser-accelerated beams.

    Science.gov (United States)

    Masood, U; Cowan, T E; Enghardt, W; Hofmann, K M; Karsch, L; Kroll, F; Schramm, U; Wilkens, J J; Pawelke, J

    2017-07-07

    Proton beams may provide superior dose-conformity in radiation therapy. However, the large sizes and costs limit the widespread use of proton therapy (PT). The recent progress in proton acceleration via high-power laser systems has made it a compelling alternative to conventional accelerators, as it could potentially reduce the overall size and cost of the PT facilities. However, the laser-accelerated beams exhibit different characteristics than conventionally accelerated beams, i.e. very intense proton bunches with large divergences and broad-energy spectra. For the application of laser-driven beams in PT, new solutions for beam transport, such as beam capture, integrated energy selection, beam shaping and delivery systems are required due to the specific beam parameters. The generation of these beams are limited by the low repetition rate of high-power lasers and this limitation would require alternative solutions for tumour irradiation which can efficiently utilize the available high proton fluence and broad-energy spectra per proton bunch to keep treatment times short. This demands new dose delivery system and irradiation field formation schemes. In this paper, we present a multi-functional light-weight and compact proton gantry design for laser-driven sources based on iron-less pulsed high-field magnets. This achromatic design includes improved beam capturing and energy selection systems, with a novel beam shaping and dose delivery system, so-called ELPIS. ELPIS system utilizes magnetic fields, instead of physical scatterers, for broadening the spot-size of broad-energetic beams while capable of simultaneously scanning them in lateral directions. To investigate the clinical feasibility of this gantry design, we conducted a treatment planning study with a 3D treatment planning system augmented for the pulsed beams with optimizable broad-energetic widths and selectable beam spot sizes. High quality treatment plans could be achieved with such unconventional beam

  8. A light-weight compact proton gantry design with a novel dose delivery system for broad-energetic laser-accelerated beams

    Science.gov (United States)

    Masood, U.; Cowan, T. E.; Enghardt, W.; Hofmann, K. M.; Karsch, L.; Kroll, F.; Schramm, U.; Wilkens, J. J.; Pawelke, J.

    2017-07-01

    Proton beams may provide superior dose-conformity in radiation therapy. However, the large sizes and costs limit the widespread use of proton therapy (PT). The recent progress in proton acceleration via high-power laser systems has made it a compelling alternative to conventional accelerators, as it could potentially reduce the overall size and cost of the PT facilities. However, the laser-accelerated beams exhibit different characteristics than conventionally accelerated beams, i.e. very intense proton bunches with large divergences and broad-energy spectra. For the application of laser-driven beams in PT, new solutions for beam transport, such as beam capture, integrated energy selection, beam shaping and delivery systems are required due to the specific beam parameters. The generation of these beams are limited by the low repetition rate of high-power lasers and this limitation would require alternative solutions for tumour irradiation which can efficiently utilize the available high proton fluence and broad-energy spectra per proton bunch to keep treatment times short. This demands new dose delivery system and irradiation field formation schemes. In this paper, we present a multi-functional light-weight and compact proton gantry design for laser-driven sources based on iron-less pulsed high-field magnets. This achromatic design includes improved beam capturing and energy selection systems, with a novel beam shaping and dose delivery system, so-called ELPIS. ELPIS system utilizes magnetic fields, instead of physical scatterers, for broadening the spot-size of broad-energetic beams while capable of simultaneously scanning them in lateral directions. To investigate the clinical feasibility of this gantry design, we conducted a treatment planning study with a 3D treatment planning system augmented for the pulsed beams with optimizable broad-energetic widths and selectable beam spot sizes. High quality treatment plans could be achieved with such unconventional beam

  9. Dosimetric comparison between proton and photon beams in the moving gap region in cranio-spinal irradiation (CSI)

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Chee-Wai; Das, Indra J.; Zhao, Li; Wolanski, Mark; Johnstone, Peter A.S.; Buchsbaum, Jeffrey C. [IU Health Proton Therapy Center, Bloomington (United States); Dept. of Radiation Oncology, Indiana Univ. School of Medicine, Indianapolis (United States)], e-mail: ccheng1@iuhealth.org; Srivastava, Shiv P. [Dept. of Radiation Oncology, Indiana Univ. School of Medicine, Indianapolis (United States); Dept. of Radiation Oncology, Reid Hospital, Richmond (United States); Simmons, Joseph [IU Health Proton Therapy Center, Bloomington (United States)

    2013-04-15

    Purpose: To investigate the moving gap region dosimetry in proton beam cranio-spinal irradiation (CSI) to provide optimal dose uniformity across the treatment volume. Material and methods: Proton beams of ranges 11.6 cm and 16 cm are used for the spine and the brain fields, respectively. Beam profiles for a 30 cm snout are first matched at the 50% level (hot match) on the computer. Feathering is simulated by shifting the dose profiles by a known distance two successive times to simulate a 2 x feathering scheme. The process is repeated for 2 mm and 4 mm gaps. Similar procedures are used to determine the dose profiles in the moving gap for a series of gap widths, 0-10 mm, and feathering step sizes, 4-10 mm, for a Varian iX 6MV beam. The proton and photon dose profiles in the moving gap region are compared. Results: The dose profiles in the moving gap exhibit valleys and peaks in both proton and photon beam CSI. The dose in the moving gap for protons is around 100% or higher for 0 mm gap, for both 5 and 10 mm feathering step sizes. When the field gap is comparable or larger than the penumbra, dose minima as low as 66% is obtained. The dosimetric characteristics for 6 MV photon beams can be made similar to those of the protons by appropriately combining gap width and feathering step size. Conclusion: The dose in the moving gap region is determined by the lateral penumbras, the width of the gap and the feathering step size. The dose decreases with increasing gap width or decreasing feathering step size. The dosimetric characteristics are similar for photon and proton beams. However, proton CSI has virtually no exit dose and is beneficial for pediatric patients, whereas with photon beams the whole lung and abdomen receive non-negligible exit dose.

  10. SU-E-T-542: Measurement of Internal Neutrons for Uniform Scanning Proton Beams

    Energy Technology Data Exchange (ETDEWEB)

    Islam, M; Ahmad, S [University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (United States); Zheng, Y; Rana, S [Procure Proton Therapy Center, Oklahoma City, OK (United States); Collums, T [University of Iowa Hospitals and Clinics, Iowa City, IA (United States); Monsoon, J; Benton, E [Oklahoma State University, Stillwater, OK (United States)

    2015-06-15

    Purpose: In proton radiotherapy, the production of neutrons is a wellknown problem since neutron exposure can lead to increased risk of secondary cancers later in the patient’s lifetime. The assessment of neutron exposure is, therefore, important for the overall quality of proton radiotherapy. This study investigates the secondary neutrons created inside the patient from uniform scanning proton beams. Methods: Dose equivalent due to secondary neutrons was measured outside the primary field as a function of distance from beam isocenter at three different angles, 45, 90 and 135 degree, relative to beam axis. Plastic track nuclear detector (CR-39 PNTD) was used for the measurement of neutron dose. Two experimental configurations, in-air and cylindrical-phantom, were designed. In a cylindrical-phantom configuration, a cylindrical phantom of 5.5 cm diameter and 35 cm long was placed along the beam direction and in an in-air configuration, no phantom was used. All the detectors were placed at nearly identical locations in both configurations. Three proton beams of range 5 cm, 18 cm, and 32 cm with 4 cm modulation width and a 5 cm diameter aperture were used. The contribution from internal neutrons was estimated from the differences in measured dose equivalent between in-air and cylindrical-phantom configurations at respective locations. Results: The measured ratio of neutron dose equivalent to the primary proton dose (H/D) dropped off with distance and ranged from 27 to 0.3 mSv/Gy. The contribution of internal neutrons near the treatment field edge was found to be up to 64 % of the total neutron exposure. As the distance from the field edge became larger, the external neutrons from the nozzle appear to dominate and the internal neutrons became less prominent. Conclusion: This study suggests that the contribution of internal neutrons could be significant to the total neutron dose equivalent.

  11. Fast pencil beam dose calculation for proton therapy using a double-Gaussian beam model

    Directory of Open Access Journals (Sweden)

    Joakim eda Silva

    2015-12-01

    Full Text Available The highly conformal dose distributions produced by scanned proton pencil beams are more sensitive to motion and anatomical changes than those produced by conventional radiotherapy. The ability to calculate the dose in real time as it is being delivered would enable, for example, online dose monitoring, and is therefore highly desirable. We have previously described an implementation of a pencil beam algorithm running on graphics processing units (GPUs intended specifically for online dose calculation. Here we present an extension to the dose calculation engine employing a double-Gaussian beam model to better account for the low-dose halo. To the best of our knowledge, it is the first such pencil beam algorithm for proton therapy running on a GPU. We employ two different parametrizations for the halo dose, one describing the distribution of secondary particles from nuclear interactions found in the literature and one relying on directly fitting the model to Monte Carlo simulations of pencil beams in water. Despite the large width of the halo contribution, we show how in either case the second Gaussian can be included whilst prolonging the calculation of the investigated plans by no more than 16%, or the calculation of the most time-consuming energy layers by about 25%. Further, the calculation time is relatively unaffected by the parametrization used, which suggests that these results should hold also for different systems. Finally, since the implementation is based on an algorithm employed by a commercial treatment planning system, it is expected that with adequate tuning, it should be able to reproduce the halo dose from a general beam line with sufficient accuracy.

  12. Test facility of proton beam utilization of the PEFP at the SNU-AMS tandem accelerator

    International Nuclear Information System (INIS)

    Kim, K. R.; Park, B. S.; Lee, H. R.

    2004-01-01

    The PEFP (Proton Engineering Frontier Project) will supply users with a 20-MeV proton beam by the middle of 2007. A survey on users' demand was performed to draw the concept for the 20-MeV user facilities and to investigate users' requirements. In the mean time, a 6-MeV test facility has been developed to give users opportunities to experiment with proton beams. That facility will be attached to the 3-MV tandem accelerator at Seoul National University.

  13. Characterization of the proton beam from an IBA Cyclone 18/9 with radiochromic film EBT2

    Energy Technology Data Exchange (ETDEWEB)

    Sansaloni, F.; Lagares, J. I.; Arce, P.; Llop, J.; Perez, J. M. [Medical Applications Unit, Technology Department, CIEMAT, Madrid (Spain); Radiochemistry Department, Molecular Imaging unit, CIC-biomaGUNE, San Sebastian (Spain); Technology Department, CIEMAT (Spain)

    2012-12-19

    The use of radiochromic films is widespread in different areas of medical physics like radiotherapy and hadrontherapy; however, radiochromic films have been scarcely used in the characterization of proton or deuteron beams generated in biomedical cyclotrons. In this paper the radiochromic film EBT2 was used to study the beam size and the proton beam energy of an IBA Cyclone 18/9 cyclotron. The results indicate that the beam size can be easily measured at a very low expense; however, an accurate determination of the beam energy might require the implementation of certain experimental improvements.

  14. Testing proton spin models with polarized beams

    International Nuclear Information System (INIS)

    Ramsey, G.P.

    1991-01-01

    We review models for spin-weighted parton distributions in a proton. Sum rules involving the nonsinglet components of the structure function xg 1 p help narrow the range of parameters in these models. The contribution of the γ 5 anomaly term depends on the size of the integrated polarized gluon distribution and experimental predictions depend on its size. We have proposed three models for the polarized gluon distributions, whose range is considerable. These model distributions give an overall range is considerable. These model distributions give an overall range of parameters that can be tested with polarized beam experiments. These are discussed with regard to specific predictions for polarized beam experiments at energies typical of UNK

  15. TECHNOLOGIES FOR DELIVERY OF PROTON AND ION BEAMS FOR RADIOTHERAPY

    CERN Document Server

    Owen, H; Alonso, J; Mackay, R

    2014-01-01

    Recent developments for the delivery of proton and ion beam therapy have been significant, and a number of technological solutions now exist for the creation and utilisation of these particles for the treatment of cancer. In this paper we review the historical development of particle accelerators used for external beam radiotherapy and discuss the more recent progress towards more capable and cost-effective sources of particles.

  16. Proteomic analysis of proton beam irradiated human melanoma cells.

    Directory of Open Access Journals (Sweden)

    Sylwia Kedracka-Krok

    Full Text Available Proton beam irradiation is a form of advanced radiotherapy providing superior distributions of a low LET radiation dose relative to that of photon therapy for the treatment of cancer. Even though this clinical treatment has been developing for several decades, the proton radiobiology critical to the optimization of proton radiotherapy is far from being understood. Proteomic changes were analyzed in human melanoma cells treated with a sublethal dose (3 Gy of proton beam irradiation. The results were compared with untreated cells. Two-dimensional electrophoresis was performed with mass spectrometry to identify the proteins. At the dose of 3 Gy a minimal slowdown in proliferation rate was seen, as well as some DNA damage. After allowing time for damage repair, the proteomic analysis was performed. In total 17 protein levels were found to significantly (more than 1.5 times change: 4 downregulated and 13 upregulated. Functionally, they represent four categories: (i DNA repair and RNA regulation (VCP, MVP, STRAP, FAB-2, Lamine A/C, GAPDH, (ii cell survival and stress response (STRAP, MCM7, Annexin 7, MVP, Caprin-1, PDCD6, VCP, HSP70, (iii cell metabolism (TIM, GAPDH, VCP, and (iv cytoskeleton and motility (Moesin, Actinin 4, FAB-2, Vimentin, Annexin 7, Lamine A/C, Lamine B. A substantial decrease (2.3 x was seen in the level of vimentin, a marker of epithelial to mesenchymal transition and the metastatic properties of melanoma.

  17. Calculation of channels for forming and transport of medical proton beams at the JINR phasotron

    International Nuclear Information System (INIS)

    Kuz'min, E.S.; Mirokhin, I.V.; Molokanov, A.G.; Obukhov, Yu.L.; Savchenko, O.V.

    1984-01-01

    Results of numerical simulation of shaping and transporting processes of therapeutic proton beams with a modified Bragg curve at the JINR phasotron are presented. The mean energy of proton beams are about 100, 130 and 200 MeV. To provide the flat-topped depth-dose distributions with a steep back slope, the method of shaping with a necessary energy spectrum from a nonmonoenergetic beam is used. It is shown by the calculations that it is possible to choose such modes of the channel operation at which clinical-physical requirements to the parameters of medical proton beams are satisfied. Extensions of flat-tops of dose peaks are 1.3 g/cm 2 , 1.7 g/cm 2 and 3.5 g/cm 2 for the 100 MeV, 130 MeV and 200 MeV beam energies, respectively. Dose rate in the peaks of modified distributions are not less than 100 rad per minute

  18. Improved design of proton source and low energy beam transport line for European Spallation Source

    Energy Technology Data Exchange (ETDEWEB)

    Neri, L., E-mail: neri@lns.infn.it; Celona, L.; Gammino, S.; Mascali, D.; Castro, G.; Ciavola, G. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, 95123 Catania (Italy); Torrisi, G. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, 95123 Catania (Italy); Dipartimento di Ingegneria dell’Informazione, delle Infrastrutture e dell’Energia Sostenibile, Università Mediterranea di Reggio Calabria, Via Graziella, 89122 Reggio Calabria (Italy); Cheymol, B.; Ponton, A. [European Spallation Source ESS AB, Lund (Sweden); Galatà, A. [Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, Viale dell' università 2, 35020 Legnaro (Italy); Patti, G. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, 95123 Catania (Italy); Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, Viale dell' università 2, 35020 Legnaro (Italy); Gozzo, A.; Lega, L. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, 95123 Catania (Italy); Dipartimento di Ingegneria Informatica e delle Telecomunicazioni, Università degli Studi di Catania, Viale Andrea Doria 6, 95123 Catania (Italy)

    2014-02-15

    The design update of the European Spallation Source (ESS) accelerator is almost complete and the construction of the prototype of the microwave discharge ion source able to provide a proton beam current larger than 70 mA to the 3.6 MeV Radio Frequency Quadrupole (RFQ) started. The source named PS-ESS (Proton Source for ESS) was designed with a flexible magnetic system and an extraction system able to merge conservative solutions with significant advances. The ESS injector has taken advantage of recent theoretical updates and new plasma diagnostics tools developed at INFN-LNS (Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare). The design strategy considers the PS-ESS and the low energy beam transport line as a whole, where the proton beam behaves like an almost neutralized non-thermalized plasma. Innovative solutions have been used as hereinafter described. Thermo-mechanical optimization has been performed to withstand the chopped beam and the misaligned focused beam over the RFQ input collimator; the results are reported here.

  19. Incorporating partial shining effects in proton pencil-beam dose calculation

    International Nuclear Information System (INIS)

    Li Yupeng; Zhang Xiaodong; Lii Mingfwu; Sahoo, Narayan; Zhu, Ron X; Gillin, Michael; Mohan, Radhe

    2008-01-01

    A range modulator wheel (RMW) is an essential component in passively scattered proton therapy. We have observed that a proton beam spot may shine on multiple steps of the RMW. Proton dose calculation algorithms normally do not consider the partial shining effect, and thus overestimate the dose at the proximal shoulder of spread-out Bragg peak (SOBP) compared with the measurement. If the SOBP is adjusted to better fit the plateau region, the entrance dose is likely to be underestimated. In this work, we developed an algorithm that can be used to model this effect and to allow for dose calculations that better fit the measured SOBP. First, a set of apparent modulator weights was calculated without considering partial shining. Next, protons spilled from the accelerator reaching the modulator wheel were simplified as a circular spot of uniform intensity. A weight-splitting process was then performed to generate a set of effective modulator weights with the partial shining effect incorporated. The SOBPs of eight options, which are used to label different combinations of proton-beam energy and scattering devices, were calculated with the generated effective weights. Our algorithm fitted the measured SOBP at the proximal and entrance regions much better than the ones without considering partial shining effect for all SOBPs of the eight options. In a prostate patient, we found that dose calculation without considering partial shining effect underestimated the femoral head and skin dose

  20. Defocusing beam line design for an irradiation facility at the TAEA SANAEM Proton Accelerator Facility

    Science.gov (United States)

    Gencer, A.; Demirköz, B.; Efthymiopoulos, I.; Yiğitoğlu, M.

    2016-07-01

    Electronic components must be tested to ensure reliable performance in high radiation environments such as Hi-Limu LHC and space. We propose a defocusing beam line to perform proton irradiation tests in Turkey. The Turkish Atomic Energy Authority SANAEM Proton Accelerator Facility was inaugurated in May 2012 for radioisotope production. The facility has also an R&D room for research purposes. The accelerator produces protons with 30 MeV kinetic energy and the beam current is variable between 10 μA and 1.2 mA. The beam kinetic energy is suitable for irradiation tests, however the beam current is high and therefore the flux must be lowered. We plan to build a defocusing beam line (DBL) in order to enlarge the beam size, reduce the flux to match the required specifications for the irradiation tests. Current design includes the beam transport and the final focusing magnets to blow up the beam. Scattering foils and a collimator is placed for the reduction of the beam flux. The DBL is designed to provide fluxes between 107 p /cm2 / s and 109 p /cm2 / s for performing irradiation tests in an area of 15.4 cm × 21.5 cm. The facility will be the first irradiation facility of its kind in Turkey.

  1. High-energy polarized proton beams a modern view

    CERN Document Server

    Hoffstaetter, Georg Heinz

    2006-01-01

    This monograph begins with a review of the basic equations of spin motion in particle accelerators. It then reviews how polarized protons can be accelerated to several tens of GeV using as examples the preaccelerators of HERA, a 6.3 km long cyclic accelerator at DESY / Hamburg. Such techniques have already been used at the AGS of BNL / New York, to accelerate polarized protons to 25 GeV. But for acceleration to energies of several hundred GeV as in RHIC, TEVATRON, HERA, LHC, or a VLHC, new problems can occur which can lead to a significantly diminished beam polarization. For these high energies, it is necessary to look in more detail at the spin motion, and for that the invariant spin field has proved to be a useful tool. This is already widely used for the description of high-energy electron beams that become polarized by the emission of spin-flip synchrotron radiation. It is shown that this field gives rise to an adiabatic invariant of spin-orbit motion and that it defines the maximum time average polarizat...

  2. Beam-induced and cosmic-ray backgrounds observed in the ATLAS detector during the LHC 2012 proton-proton running period

    International Nuclear Information System (INIS)

    Aad, G.; Abbott, B.; Abdallah, J.; Abdinov, O.; Abeloos, B.; Aben, R.; Abolins, M.; AbouZeid, O.S.; Abraham, N.L.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B.S.; Adamczyk, L.; Adams, D.L.; Adelman, J.

    2016-01-01

    This paper discusses various observations on beam-induced and cosmic-ray backgrounds in the ATLAS detector during the LHC 2012 proton-proton run. Building on published results based on 2011 data, the correlations between background and residual pressure of the beam vacuum are revisited. Ghost charge evolution over 2012 and its role for backgrounds are evaluated. New methods to monitor ghost charge with beam-gas rates are presented and observations of LHC abort gap population by ghost charge are discussed in detail. Fake jets from colliding bunches and from ghost charge are analysed with improved methods, showing that ghost charge in individual radio-frequency buckets of the LHC can be resolved. Some results of two short periods of dedicated cosmic-ray background data-taking are shown; in particular cosmic-ray muon induced fake jet rates are compared to Monte Carlo simulations and to the fake jet rates from beam background. A thorough analysis of a particular LHC fill, where abnormally high background was observed, is presented. Correlations between backgrounds and beam intensity losses in special fills with very high β * are studied.

  3. Fabrication of phosphor micro-grids using proton beam lithography

    International Nuclear Information System (INIS)

    Rossi, Paolo; Antolak, Arlyn J.; Provencio, Paula Polyak; Doyle, Barney Lee; Malmqvist, Klas; Hearne, Sean Joseph; Nilsson, Christer; Kristiansson, Per; Wegden, Marie; Elfman, Mikael; Pallon, Jan; Auzelyte, Vaida

    2005-01-01

    A new nuclear microscopy technique called ion photon emission microscopy or IPEM was recently invented. IPEM allows analysis involving single ions, such as ion beam induced charge (IBIC) or single event upset (SEU) imaging using a slightly modified optical microscope. The spatial resolution of IPEM is currently limited to more than 10 (micro)m by the scattering and reflection of ion-induced photons, i.e. light blooming or spreading, in the ionoluminescent phosphor layer. We are developing a 'Microscopic Gridded Phosphor' (also called Black Matrix) where the phosphor nanocrystals are confined within the gaps of a micrometer scale opaque grid, which limits the amount of detrimental light blooming. MeV-energy proton beam lithography is ideally suited to lithographically form masks for the grid because of high aspect ratio, pattern density and sub-micron resolution of this technique. In brief, the fabrication of the grids was made in the following manner: (1) a MeV proton beam focused to 1.5-2 (micro)m directly fabricated a matrix of pillars in a 15 (micro)m thick SU-8 lithographic resist; (2) 7:1 aspect ratio pillars were then formed by developing the proton exposed area; (3) Ni (Au) was electrochemically deposited onto Cu-coated Si from a sulfamate bath (or buffered CN bath); (4) the SU-8 pillars were removed by chemical etching; finally (5) the metal micro-grid was freed from its substrate by etching the underlying Cu layer. Our proposed metal micro-grids promise an order-of-magnitude improvement in the resolution of IPEM.

  4. A study on the proton beam energy(50 MeV) measurement and diagnosis (II)

    Energy Technology Data Exchange (ETDEWEB)

    Chae, Jong Suh; Lee, Dong Hoon; Kim, Yoo Suk; Park, Chan Won; Lee, Yong Min; Hong, Sung Suk; Lee, Min Yong; Lee, Ji Sub; Hah, Hang Hoh [Korea Cancer Center Hospital of Korea Atomic Energy Research Institute, Seoul (Korea, Republic of)

    1995-02-01

    The main purpose of this project is the precise ion measurement of proton beam energy extracted at RF 25.89 MHz from the MC-50 cyclotron of SF type. There are several method for particle energy measurement. We measured the 50 MeV proton energy by using the E-{Delta}E method in 1993. And also in our experiment used range, reapproval of energy of extracted proton beam at RF 25.89 MHz was performed, which attained the same energy with the result used elastic scattering within the error range. 10 figs, 2 pix, 3 tabs, 3 refs. (Author).

  5. Beam Loss Calibration Studies for High Energy Proton Accelerators

    CERN Document Server

    Stockner, M

    2007-01-01

    CERN's Large Hadron Collider (LHC) is a proton collider with injection energy of 450 GeV and collision energy of 7 TeV. Superconducting magnets keep the particles circulating in two counter rotating beams, which cross each other at the Interaction Points (IP). Those complex magnets have been designed to contain both beams in one yoke within a cryostat. An unprecedented amount of energy will be stored in the circulating beams and in the magnet system. The LHC outperforms other existing accelerators in its maximum beam energy by a factor of 7 and in its beam intensity by a factor of 23. Even a loss of a small fraction of the beam particles may cause the transition from the superconducting to the normal conducting state of the coil or cause physical damage to machine components. The unique combination of these extreme beam parameters and the highly advanced superconducting technology has the consequence that the LHC needs a more efficient beam cleaning and beam loss measurement system than previous accelerators....

  6. Simulation study on beam loss in the alpha bucket regime during SIS-100 proton operation

    Science.gov (United States)

    Sorge, S.

    2018-02-01

    Crossing the transition energy γt in synchrotrons for high intensity proton beams requires well tuned jump schemes and is usually accompanied by longitudinal emittance growth. In order to avoid γt crossing during proton operation in the projected SIS-100 synchrotron special high-γt lattice settings have been developed, in order to keep γt above the beam extraction energy. A further advantage of this scheme is the formation of alpha buckets which naturally lead to short proton bunches, required for the foreseen production and storage of antiprotons for the FAIR facility. Special attention is turned on the imperfections of the superconducting SIS-100 magnets because together with the high-γt lattice settings, they could potentially lead to enhanced beam loss. The aim of the present work is to estimate the beam loss by means of particle tracking simulations.

  7. Simulation studies of macroparticles falling into the LHC Proton Beam

    CERN Document Server

    Fuster Martinez, N; Zimmermann, F; Baer, T; Giovannozzi, M; Holzer, E B; Nebot Del Busto, E; Nordt, A; Sapinski, M; Yang, Z

    2011-01-01

    We report updated simulations on the interaction of macroparticles falling from the top of the vacuum chamber into the circulating LHC proton beam. The path and charge state of micron size micro-particles are computed together with the resulting beam losses, which — if high enough — can lead to the local quench of superconducting (SC) magnets. The simulated time evolution of the beam loss is compared with observations in order to constrain some macroparticle parameters. We also discuss the possibility of a “multiple crossing” by the same macroparticle, the effect of a strong dipole field, and the dependence of peak loss rate and loss duration on beam current and on beam size.

  8. Technical Note: Spot characteristic stability for proton pencil beam scanning

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chin-Cheng, E-mail: chen.ccc@gmail.com; Chang, Chang; Mah, Dennis [ProCure Treatment Center, Somerset, New Jersey 08873 (United States); Moyers, Michael F. [ProCure Treatment Center, Somerset, New Jersey 08873 and Shanghai Proton and Heavy Ion Center, Shanghai 201321 (China); Gao, Mingcheng [CDH Proton Center, Warrenville, Illinois 60555 (United States)

    2016-02-15

    Purpose: The spot characteristics for proton pencil beam scanning (PBS) were measured and analyzed over a 16 month period, which included one major site configuration update and six cyclotron interventions. The results provide a reference to establish the quality assurance (QA) frequency and tolerance for proton pencil beam scanning. Methods: A simple treatment plan was generated to produce an asymmetric 9-spot pattern distributed throughout a field of 16 × 18 cm for each of 18 proton energies (100.0–226.0 MeV). The delivered fluence distribution in air was measured using a phosphor screen based CCD camera at three planes perpendicular to the beam line axis (x-ray imaging isocenter and up/down stream 15.0 cm). The measured fluence distributions for each energy were analyzed using in-house programs which calculated the spot sizes and positional deviations of the Gaussian shaped spots. Results: Compared to the spot characteristic data installed into the treatment planning system, the 16-month averaged deviations of the measured spot sizes at the isocenter plane were 2.30% and 1.38% in the IEC gantry x and y directions, respectively. The maximum deviation was 12.87% while the minimum deviation was 0.003%, both at the upstream plane. After the collinearity of the proton and x-ray imaging system isocenters was optimized, the positional deviations of the spots were all within 1.5 mm for all three planes. During the site configuration update, spot positions were found to deviate by 6 mm until the tuning parameters file was properly restored. Conclusions: For this beam delivery system, it is recommended to perform a spot size and position check at least monthly and any time after a database update or cyclotron intervention occurs. A spot size deviation tolerance of <15% can be easily met with this delivery system. Deviations of spot positions were <2 mm at any plane up/down stream 15 cm from the isocenter.

  9. Technical Note: Spot characteristic stability for proton pencil beam scanning

    International Nuclear Information System (INIS)

    Chen, Chin-Cheng; Chang, Chang; Mah, Dennis; Moyers, Michael F.; Gao, Mingcheng

    2016-01-01

    Purpose: The spot characteristics for proton pencil beam scanning (PBS) were measured and analyzed over a 16 month period, which included one major site configuration update and six cyclotron interventions. The results provide a reference to establish the quality assurance (QA) frequency and tolerance for proton pencil beam scanning. Methods: A simple treatment plan was generated to produce an asymmetric 9-spot pattern distributed throughout a field of 16 × 18 cm for each of 18 proton energies (100.0–226.0 MeV). The delivered fluence distribution in air was measured using a phosphor screen based CCD camera at three planes perpendicular to the beam line axis (x-ray imaging isocenter and up/down stream 15.0 cm). The measured fluence distributions for each energy were analyzed using in-house programs which calculated the spot sizes and positional deviations of the Gaussian shaped spots. Results: Compared to the spot characteristic data installed into the treatment planning system, the 16-month averaged deviations of the measured spot sizes at the isocenter plane were 2.30% and 1.38% in the IEC gantry x and y directions, respectively. The maximum deviation was 12.87% while the minimum deviation was 0.003%, both at the upstream plane. After the collinearity of the proton and x-ray imaging system isocenters was optimized, the positional deviations of the spots were all within 1.5 mm for all three planes. During the site configuration update, spot positions were found to deviate by 6 mm until the tuning parameters file was properly restored. Conclusions: For this beam delivery system, it is recommended to perform a spot size and position check at least monthly and any time after a database update or cyclotron intervention occurs. A spot size deviation tolerance of <15% can be easily met with this delivery system. Deviations of spot positions were <2 mm at any plane up/down stream 15 cm from the isocenter

  10. Selective Adsorption of Nano-bio materials and nanostructure fabrication on Molecular Resists Modified by proton beam irradiation

    International Nuclear Information System (INIS)

    Lee, H. W.; Kim, H. S.; Kim, S. M.

    2008-04-01

    The purpose of this research is the fabrication of nanostructures on silicon substrate using proton beam and selectively adsorption of bio-nano materials on the patterned substrate. Recently, the miniaturization of the integrated devices with fine functional structures was intensively investigated, based on combination of nanotechnology (NT), biotechnology (BT) and information technology (IT). Because of the inherent limitation in optical lithography, large variety of novel patterning technologies were evolved to construct nano-structures onto a substrate. Atomic force microscope-based nanolithography has readily formed sub-50 nm patterns by the local modification of a substrate using a probe with a curvature of 10 nm. The surface property was regarded as one of the most important factors for AFM-based nanolithography as well as for other novel nanolithographies. The molecular thin films such as a self-assembled monolayer or a polymer resist layer have been used as an alternative to modifying the surface property. Although proton or ion beam irradiation has been used as an efficient tool to modify the physical, chemical and electrical properties of a surface, the nano-patterning on the substrate or the molecular film modified with the beam irradiation has hardly been studied at both home and abroad. The selective adsorption of nano-bio materials such as carbon nanotubes and proteins on the patterns would contribute to developing the integrated devices. The polystyrene nanoparticles (400 nm) were arrayed on al silicon surface using nanosphere lithography and the various nanopatterns were fabricated by proton beam irradiation on the polystyrene nanoparticles arrayed silicon surface. We obtained the two different nanopatterns such as polymer nanoring patterns and silicon oxide patterns on the same silicon substrate. The polymer nanoring patterns formed by the crosslinkage of polystyrene when proton beam was irradiated at the triangular void spaces that are enclosed by

  11. Design study of the ESS-Bilbao 50 MeV proton beam line for radiobiological studies

    Energy Technology Data Exchange (ETDEWEB)

    Huerta-Parajon, M., E-mail: mhuerta@essbilbao.org; Martinez-Ballarin, R., E-mail: rmartinez@essbilbao.org; Abad, E., E-mail: eabad@essbilbao.org

    2015-02-01

    The ESS-Bilbao proton accelerator facility has been designed fulfilling the European Spallation Source (ESS) specifications to serve as the Spanish contribution to the ESS construction. Furthermore, several applications of the ESS-Bilbao proton beam are being considered in order to contribute to the knowledge in the field of radiobiology, materials and aerospace components. Understanding of the interaction of radiation with biological systems is of vital importance as it affects important applications such as cancer treatment with ion beam therapy among others. ESS-Bilbao plans to house a facility exclusively dedicated to radiobiological experiments with protons up to 50 MeV. Beam line design, optimisation and initial calculations of flux densities and absorbed doses were undertaken using the Monte Carlo simulation package FLUKA. A proton beam with a flux density of about 10{sup 6} protons/cm{sup 2} s reaches the water sample with a flat lateral distribution of the dose. The absorbed dose at the pristine Bragg peak calculated with FLUKA is 2.4 ± 0.1 Gy in 1 min of irradiation time. This value agrees with the clinically meaningful dose rates, i.e. around 2 Gy/min, used in hadrontherapy. Optimisation and validation studies in the ESS-Bilbao line for radiobiological experiments are detailed in this article.

  12. Beam-induced and cosmic-ray backgrounds observed in the ATLAS detector during the LHC 2012 proton-proton running period

    CERN Document Server

    Aad, Georges; Abdallah, Jalal; Abdinov, Ovsat; Abeloos, Baptiste; Aben, Rosemarie; Abolins, Maris; AbouZeid, Ossama; Abraham, Nicola; Abramowicz, Halina; Abreu, Henso; Abreu, Ricardo; Abulaiti, Yiming; Acharya, Bobby Samir; Adamczyk, Leszek; Adams, David; Adelman, Jahred; Adomeit, Stefanie; Adye, Tim; Affolder, Tony; Agatonovic-Jovin, Tatjana; Agricola, Johannes; Aguilar-Saavedra, Juan Antonio; Ahlen, Steven; Ahmadov, Faig; Aielli, Giulio; Akerstedt, Henrik; Åkesson, Torsten Paul Ake; Akimov, Andrei; Alberghi, Gian Luigi; Albert, Justin; Albrand, Solveig; Alconada Verzini, Maria Josefina; Aleksa, Martin; Aleksandrov, Igor; Alexa, Calin; Alexander, Gideon; Alexopoulos, Theodoros; Alhroob, Muhammad; Aliev, Malik; Alimonti, Gianluca; Alison, John; Alkire, Steven Patrick; Allbrooke, Benedict; Allen, Benjamin William; Allport, Phillip; Aloisio, Alberto; Alonso, Alejandro; Alonso, Francisco; Alpigiani, Cristiano; Alvarez Gonzalez, Barbara; Άlvarez Piqueras, Damián; Alviggi, Mariagrazia; Amadio, Brian Thomas; Amako, Katsuya; Amaral Coutinho, Yara; Amelung, Christoph; Amidei, Dante; Amor Dos Santos, Susana Patricia; Amorim, Antonio; Amoroso, Simone; Amram, Nir; Amundsen, Glenn; Anastopoulos, Christos; Ancu, Lucian Stefan; Andari, Nansi; Andeen, Timothy; Anders, Christoph Falk; Anders, Gabriel; Anders, John Kenneth; Anderson, Kelby; Andreazza, Attilio; Andrei, George Victor; Angelidakis, Stylianos; Angelozzi, Ivan; Anger, Philipp; Angerami, Aaron; Anghinolfi, Francis; Anisenkov, Alexey; Anjos, Nuno; Annovi, Alberto; Antonelli, Mario; Antonov, Alexey; Antos, Jaroslav; Anulli, Fabio; Aoki, Masato; Aperio Bella, Ludovica; Arabidze, Giorgi; Arai, Yasuo; Araque, Juan Pedro; Arce, Ayana; Arduh, Francisco Anuar; Arduini, Gianluigi; Arguin, Jean-Francois; Argyropoulos, Spyridon; Arik, Metin; Armbruster, Aaron James; Armitage, Lewis James; Arnaez, Olivier; Arnold, Hannah; Arratia, Miguel; Arslan, Ozan; Artamonov, Andrei; Artoni, Giacomo; Artz, Sebastian; Asai, Shoji; Asbah, Nedaa; Ashkenazi, Adi; Åsman, Barbro; Asquith, Lily; Assamagan, Ketevi; Astalos, Robert; Atkinson, Markus; Atlay, Naim Bora; Augsten, Kamil; Avolio, Giuseppe; Axen, Bradley; Ayoub, Mohamad Kassem; Azuelos, Georges; Baak, Max; Baas, Alessandra; Baca, Matthew John; Bachacou, Henri; Bachas, Konstantinos; Backes, Moritz; Backhaus, Malte; Bagiacchi, Paolo; Bagnaia, Paolo; Bai, Yu; Baines, John; Baker, Oliver Keith; Baldin, Evgenii; Balek, Petr; Balestri, Thomas; Balli, Fabrice; Balunas, William Keaton; Banas, Elzbieta; Banerjee, Swagato; Bannoura, Arwa A E; Barak, Liron; Barberio, Elisabetta Luigia; Barberis, Dario; Barbero, Marlon; Barillari, Teresa; Barklow, Timothy; Barlow, Nick; Barnes, Sarah Louise; Barnett, Bruce; Barnett, Michael; Barnovska, Zuzana; Baroncelli, Antonio; Barone, Gaetano; Barr, Alan; Barranco Navarro, Laura; Barreiro, Fernando; Barreiro Guimarães da Costa, João; Bartoldus, Rainer; Barton, Adam Edward; Bartos, Pavol; Basalaev, Artem; Bassalat, Ahmed; Basye, Austin; Bates, Richard; Batista, Santiago Juan; Batley, Richard; Battaglia, Marco; Bauce, Matteo; Bauer, Florian; Bawa, Harinder Singh; Beacham, James Baker; Beattie, Michael David; Beau, Tristan; Beauchemin, Pierre-Hugues; Bechtle, Philip; Beck, Hans~Peter; Becker, Kathrin; Becker, Maurice; Beckingham, Matthew; Becot, Cyril; Beddall, Andrew; Beddall, Ayda; Bednyakov, Vadim; Bedognetti, Matteo; Bee, Christopher; Beemster, Lars; Beermann, Thomas; Begel, Michael; Behr, Janna Katharina; Belanger-Champagne, Camille; Bell, Andrew Stuart; Bella, Gideon; Bellagamba, Lorenzo; Bellerive, Alain; Bellomo, Massimiliano; Belotskiy, Konstantin; Beltramello, Olga; Belyaev, Nikita; Benary, Odette; Benchekroun, Driss; Bender, Michael; Bendtz, Katarina; Benekos, Nektarios; Benhammou, Yan; Benhar Noccioli, Eleonora; Benitez, Jose; Benitez Garcia, Jorge-Armando; Benjamin, Douglas; Bensinger, James; Bentvelsen, Stan; Beresford, Lydia; Beretta, Matteo; Berge, David; Bergeaas Kuutmann, Elin; Berger, Nicolas; Berghaus, Frank; Beringer, Jürg; Berlendis, Simon; Bernard, Nathan Rogers; Bernius, Catrin; Bernlochner, Florian Urs; Berry, Tracey; Berta, Peter; Bertella, Claudia; Bertoli, Gabriele; Bertolucci, Federico; Bertram, Iain Alexander; Bertsche, Carolyn; Bertsche, David; Besjes, Geert-Jan; Bessidskaia Bylund, Olga; Bessner, Martin Florian; Besson, Nathalie; Betancourt, Christopher; Bethke, Siegfried; Bevan, Adrian John; Bhimji, Wahid; Bianchi, Riccardo-Maria; Bianchini, Louis; Bianco, Michele; Biebel, Otmar; Biedermann, Dustin; Bielski, Rafal; Biesuz, Nicolo Vladi; Biglietti, Michela; Bilbao De Mendizabal, Javier; Bilokon, Halina; Bindi, Marcello; Binet, Sebastien; Bingul, Ahmet; Bini, Cesare; Biondi, Silvia; Bjergaard, David Martin; Black, Curtis; Black, James; Black, Kevin; Blackburn, Daniel; Blair, Robert; Blanchard, Jean-Baptiste; Blanco, Jacobo Ezequiel; Blazek, Tomas; Bloch, Ingo; Blocker, Craig; Blum, Walter; Blumenschein, Ulrike; Blunier, Sylvain; Bobbink, Gerjan; Bobrovnikov, Victor; Bocchetta, Simona Serena; Bocci, Andrea; Bock, Christopher; Boehler, Michael; Boerner, Daniela; Bogaerts, Joannes Andreas; Bogavac, Danijela; Bogdanchikov, Alexander; Bohm, Christian; Boisvert, Veronique; Bold, Tomasz; Boldea, Venera; Boldyrev, Alexey; Bomben, Marco; Bona, Marcella; Boonekamp, Maarten; Borisov, Anatoly; Borissov, Guennadi; Bortfeldt, Jonathan; Bortoletto, Daniela; Bortolotto, Valerio; Bos, Kors; Boscherini, Davide; Bosman, Martine; Bossio Sola, Jonathan David; Boudreau, Joseph; Bouffard, Julian; Bouhova-Thacker, Evelina Vassileva; Boumediene, Djamel Eddine; Bourdarios, Claire; Boutle, Sarah Kate; Boveia, Antonio; Boyd, James; Boyko, Igor; Bracinik, Juraj; Brandt, Andrew; Brandt, Gerhard; Brandt, Oleg; Bratzler, Uwe; Brau, Benjamin; Brau, James; Braun, Helmut; Breaden Madden, William Dmitri; Brendlinger, Kurt; Brennan, Amelia Jean; Brenner, Lydia; Brenner, Richard; Bressler, Shikma; Bristow, Timothy Michael; Britton, Dave; Britzger, Daniel; Brochu, Frederic; Brock, Ian; Brock, Raymond; Brooijmans, Gustaaf; Brooks, Timothy; Brooks, William; Brosamer, Jacquelyn; Brost, Elizabeth; Broughton, James; Bruce, Roderik; Bruckman de Renstrom, Pawel; Bruncko, Dusan; Bruneliere, Renaud; Bruni, Alessia; Bruni, Graziano; Brunt, Benjamin; Bruschi, Marco; Bruscino, Nello; Bryant, Patrick; Bryngemark, Lene; Buanes, Trygve; Buat, Quentin; Buchholz, Peter; Buckley, Andrew; Budagov, Ioulian; Buehrer, Felix; Bugge, Magnar Kopangen; Bulekov, Oleg; Bullock, Daniel; Burckhart, Helfried; Burdin, Sergey; Burgard, Carsten Daniel; Burghgrave, Blake; Burka, Klaudia; Burke, Stephen; Burmeister, Ingo; Busato, Emmanuel; Büscher, Daniel; Büscher, Volker; Bussey, Peter; Butler, John; Butt, Aatif Imtiaz; Buttar, Craig; Butterworth, Jonathan; Butti, Pierfrancesco; Buttinger, William; Buzatu, Adrian; Buzykaev, Aleksey; Cabrera Urbán, Susana; Caforio, Davide; Cairo, Valentina; Cakir, Orhan; Calace, Noemi; Calafiura, Paolo; Calandri, Alessandro; Calderini, Giovanni; Calfayan, Philippe; Caloba, Luiz; Calvet, David; Calvet, Samuel; Calvet, Thomas Philippe; Camacho Toro, Reina; Camarda, Stefano; Camarri, Paolo; Cameron, David; Caminal Armadans, Roger; Camincher, Clement; Campana, Simone; Campanelli, Mario; Campoverde, Angel; Canale, Vincenzo; Canepa, Anadi; Cano Bret, Marc; Cantero, Josu; Cantrill, Robert; Cao, Tingting; Capeans Garrido, Maria Del Mar; Caprini, Irinel; Caprini, Mihai; Capua, Marcella; Caputo, Regina; Carbone, Ryne Michael; Cardarelli, Roberto; Cardillo, Fabio; Carli, Tancredi; Carlino, Gianpaolo; Carminati, Leonardo; Caron, Sascha; Carquin, Edson; Carrillo-Montoya, German D; Carter, Janet; Carvalho, João; Casadei, Diego; Casado, Maria Pilar; Casolino, Mirkoantonio; Casper, David William; Castaneda-Miranda, Elizabeth; Castelli, Angelantonio; Castillo Gimenez, Victoria; Castro, Nuno Filipe; Catinaccio, Andrea; Catmore, James; Cattai, Ariella; Caudron, Julien; Cavaliere, Viviana; Cavallaro, Emanuele; Cavalli, Donatella; Cavalli-Sforza, Matteo; Cavasinni, Vincenzo; Ceradini, Filippo; Cerda Alberich, Leonor; Cerio, Benjamin; Santiago Cerqueira, Augusto; Cerri, Alessandro; Cerrito, Lucio; Cerutti, Fabio; Cerv, Matevz; Cervelli, Alberto; Cetin, Serkant Ali; Chafaq, Aziz; Chakraborty, Dhiman; Chalupkova, Ina; Chan, Stephen Kam-wah; Chan, Yat Long; Chang, Philip; Chapman, John Derek; Charlton, Dave; Chatterjee, Avishek; Chau, Chav Chhiv; Chavez Barajas, Carlos Alberto; Che, Siinn; Cheatham, Susan; Chegwidden, Andrew; Chekanov, Sergei; Chekulaev, Sergey; Chelkov, Gueorgui; Chelstowska, Magda Anna; Chen, Chunhui; Chen, Hucheng; Chen, Karen; Chen, Shenjian; Chen, Shion; Chen, Xin; Chen, Ye; Cheng, Hok Chuen; Cheng, Huajie; Cheng, Yangyang; Cheplakov, Alexander; Cheremushkina, Evgenia; Cherkaoui El Moursli, Rajaa; Chernyatin, Valeriy; Cheu, Elliott; Chevalier, Laurent; Chiarella, Vitaliano; Chiarelli, Giorgio; Chiodini, Gabriele; Chisholm, Andrew; Chitan, Adrian; Chizhov, Mihail; Choi, Kyungeon; Chomont, Arthur Rene; Chouridou, Sofia; Chow, Bonnie Kar Bo; Christodoulou, Valentinos; Chromek-Burckhart, Doris; Chudoba, Jiri; Chuinard, Annabelle Julia; Chwastowski, Janusz; Chytka, Ladislav; Ciapetti, Guido; Ciftci, Abbas Kenan; Cinca, Diane; Cindro, Vladimir; Cioara, Irina Antonela; Ciocio, Alessandra; Cirotto, Francesco; Citron, Zvi Hirsh; Ciubancan, Mihai; Clark, Allan G; Clark, Brian Lee; Clark, Michael; Clark, Philip James; Clarke, Robert; Clement, Christophe; Coadou, Yann; Cobal, Marina; Coccaro, Andrea; Cochran, James H; Coffey, Laurel; Colasurdo, Luca; Cole, Brian; Cole, Stephen; Colijn, Auke-Pieter; Collot, Johann; Colombo, Tommaso; Compostella, Gabriele; Conde Muiño, Patricia; Coniavitis, Elias; Connell, Simon Henry; Connelly, Ian; Consorti, Valerio; Constantinescu, Serban; Conta, Claudio; Conti, Geraldine; Conventi, Francesco; Cooke, Mark; Cooper, Ben; Cooper-Sarkar, Amanda; Cornelissen, Thijs; Corradi, Massimo; Corriveau, Francois; Corso-Radu, Alina; Cortes-Gonzalez, Arely; Cortiana, Giorgio; Costa, Giuseppe; Costa, María José; Costanzo, Davide; Cottin, Giovanna; Cowan, Glen; Cox, Brian; Cranmer, Kyle; Crawley, Samuel Joseph; Cree, Graham; Crépé-Renaudin, Sabine; Crescioli, Francesco; Cribbs, Wayne Allen; Crispin Ortuzar, Mireia; Cristinziani, Markus; Croft, Vince; Crosetti, Giovanni; Cuhadar Donszelmann, Tulay; Cummings, Jane; Curatolo, Maria; Cúth, Jakub; Cuthbert, Cameron; Czirr, Hendrik; Czodrowski, Patrick; D'Auria, Saverio; D'Onofrio, Monica; Da Cunha Sargedas De Sousa, Mario Jose; Da Via, Cinzia; Dabrowski, Wladyslaw; Dai, Tiesheng; Dale, Orjan; Dallaire, Frederick; Dallapiccola, Carlo; Dam, Mogens; Dandoy, Jeffrey Rogers; Dang, Nguyen Phuong; Daniells, Andrew Christopher; Dann, Nicholas Stuart; Danninger, Matthias; Dano Hoffmann, Maria; Dao, Valerio; Darbo, Giovanni; Darmora, Smita; Dassoulas, James; Dattagupta, Aparajita; Davey, Will; David, Claire; Davidek, Tomas; Davies, Merlin; Davison, Peter; Davygora, Yuriy; Dawe, Edmund; Dawson, Ian; Daya-Ishmukhametova, Rozmin; De, Kaushik; de Asmundis, Riccardo; De Benedetti, Abraham; De Castro, Stefano; De Cecco, Sandro; De Groot, Nicolo; de Jong, Paul; De la Torre, Hector; De Lorenzi, Francesco; De Pedis, Daniele; De Salvo, Alessandro; De Sanctis, Umberto; De Santo, Antonella; De Vivie De Regie, Jean-Baptiste; Dearnaley, William James; Debbe, Ramiro; Debenedetti, Chiara; Dedovich, Dmitri; Deigaard, Ingrid; Del Peso, Jose; Del Prete, Tarcisio; Delgove, David; Deliot, Frederic; Delitzsch, Chris Malena; Deliyergiyev, Maksym; Dell'Acqua, Andrea; Dell'Asta, Lidia; Dell'Orso, Mauro; Della Pietra, Massimo; della Volpe, Domenico; Delmastro, Marco; Delsart, Pierre-Antoine; Deluca, Carolina; DeMarco, David; Demers, Sarah; Demichev, Mikhail; Demilly, Aurelien; Denisov, Sergey; Denysiuk, Denys; Derendarz, Dominik; Derkaoui, Jamal Eddine; Derue, Frederic; Dervan, Paul; Desch, Klaus Kurt; Deterre, Cecile; Dette, Karola; Deviveiros, Pier-Olivier; Dewhurst, Alastair; Dhaliwal, Saminder; Di Ciaccio, Anna; Di Ciaccio, Lucia; Di Clemente, William Kennedy; Di Donato, Camilla; Di Girolamo, Alessandro; Di Girolamo, Beniamino; Di Micco, Biagio; Di Nardo, Roberto; Di Simone, Andrea; Di Sipio, Riccardo; Di Valentino, David; Diaconu, Cristinel; Diamond, Miriam; Dias, Flavia; Diaz, Marco Aurelio; Diehl, Edward; Dietrich, Janet; Diglio, Sara; Dimitrievska, Aleksandra; Dingfelder, Jochen; Dita, Petre; Dita, Sanda; Dittus, Fridolin; Djama, Fares; Djobava, Tamar; Djuvsland, Julia Isabell; Barros do Vale, Maria Aline; Dobos, Daniel; Dobre, Monica; Doglioni, Caterina; Dohmae, Takeshi; Dolejsi, Jiri; Dolezal, Zdenek; Dolgoshein, Boris; Donadelli, Marisilvia; Donati, Simone; Dondero, Paolo; Donini, Julien; Dopke, Jens; Doria, Alessandra; Dova, Maria-Teresa; Doyle, Tony; Drechsler, Eric; Dris, Manolis; Du, Yanyan; Duarte-Campderros, Jorge; Duchovni, Ehud; Duckeck, Guenter; Ducu, Otilia Anamaria; Duda, Dominik; Dudarev, Alexey; Duflot, Laurent; Duguid, Liam; Dührssen, Michael; Dunford, Monica; Duran Yildiz, Hatice; Düren, Michael; Durglishvili, Archil; Duschinger, Dirk; Dutta, Baishali; Dyndal, Mateusz; Eckardt, Christoph; Ecker, Katharina Maria; Edgar, Ryan Christopher; Edson, William; Edwards, Nicholas Charles; Eifert, Till; Eigen, Gerald; Einsweiler, Kevin; Ekelof, Tord; El Kacimi, Mohamed; Ellajosyula, Venugopal; Ellert, Mattias; Elles, Sabine; Ellinghaus, Frank; Elliot, Alison; Ellis, Nicolas; Elmsheuser, Johannes; Elsing, Markus; Emeliyanov, Dmitry; Enari, Yuji; Endner, Oliver Chris; Endo, Masaki; Ennis, Joseph Stanford; Erdmann, Johannes; Ereditato, Antonio; Ernis, Gunar; Ernst, Jesse; Ernst, Michael; Errede, Steven; Ertel, Eugen; Escalier, Marc; Esch, Hendrik; Escobar, Carlos; Esposito, Bellisario; Etienvre, Anne-Isabelle; Etzion, Erez; Evans, Hal; Ezhilov, Alexey; Fabbri, Federica; Fabbri, Laura; Facini, Gabriel; Fakhrutdinov, Rinat; Falciano, Speranza; Falla, Rebecca Jane; Faltova, Jana; Fang, Yaquan; Fanti, Marcello; Farbin, Amir; Farilla, Addolorata; Farina, Christian; Farooque, Trisha; Farrell, Steven; Farrington, Sinead; Farthouat, Philippe; Fassi, Farida; Fassnacht, Patrick; Fassouliotis, Dimitrios; Faucci Giannelli, Michele; Favareto, Andrea; Fawcett, William James; Fayard, Louis; Fedin, Oleg; Fedorko, Wojciech; Feigl, Simon; Feligioni, Lorenzo; Feng, Cunfeng; Feng, Eric; Feng, Haolu; Fenyuk, Alexander; Feremenga, Last; Fernandez Martinez, Patricia; Fernandez Perez, Sonia; Ferrando, James; Ferrari, Arnaud; Ferrari, Pamela; Ferrari, Roberto; Ferreira de Lima, Danilo Enoque; Ferrer, Antonio; Ferrere, Didier; Ferretti, Claudio; Ferretto Parodi, Andrea; Fiedler, Frank; Filipčič, Andrej; Filipuzzi, Marco; Filthaut, Frank; Fincke-Keeler, Margret; Finelli, Kevin Daniel; Fiolhais, Miguel; Fiorini, Luca; Firan, Ana; Fischer, Adam; Fischer, Cora; Fischer, Julia; Fisher, Wade Cameron; Flaschel, Nils; Fleck, Ivor; Fleischmann, Philipp; Fletcher, Gareth Thomas; Fletcher, Gregory; Fletcher, Rob Roy MacGregor; Flick, Tobias; Floderus, Anders; Flores Castillo, Luis; Flowerdew, Michael; Forcolin, Giulio Tiziano; Formica, Andrea; Forti, Alessandra; Foster, Andrew Geoffrey; Fournier, Daniel; Fox, Harald; Fracchia, Silvia; Francavilla, Paolo; Franchini, Matteo; Francis, David; Franconi, Laura; Franklin, Melissa; Frate, Meghan; Fraternali, Marco; Freeborn, David; Fressard-Batraneanu, Silvia; Friedrich, Felix; Froidevaux, Daniel; Frost, James; Fukunaga, Chikara; Fullana Torregrosa, Esteban; Fusayasu, Takahiro; Fuster, Juan; Gabaldon, Carolina; Gabizon, Ofir; Gabrielli, Alessandro; Gabrielli, Andrea; Gach, Grzegorz; Gadatsch, Stefan; Gadomski, Szymon; Gagliardi, Guido; Gagnon, Louis Guillaume; Gagnon, Pauline; Galea, Cristina; Galhardo, Bruno; Gallas, Elizabeth; Gallop, Bruce; Gallus, Petr; Galster, Gorm Aske Gram Krohn; Gan, KK; Gao, Jun; Gao, Yanyan; Gao, Yongsheng; Garay Walls, Francisca; García, Carmen; García Navarro, José Enrique; Garcia-Sciveres, Maurice; Gardner, Robert; Garelli, Nicoletta; Garonne, Vincent; Gascon Bravo, Alberto; Gatti, Claudio; Gaudiello, Andrea; Gaudio, Gabriella; Gaur, Bakul; Gauthier, Lea; Gavrilenko, Igor; Gay, Colin; Gaycken, Goetz; Gazis, Evangelos; Gecse, Zoltan; Gee, Norman; Geich-Gimbel, Christoph; Geisler, Manuel Patrice; Gemme, Claudia; Genest, Marie-Hélène; Geng, Cong; Gentile, Simonetta; George, Simon; Gerbaudo, Davide; Gershon, Avi; Ghasemi, Sara; Ghazlane, Hamid; Ghneimat, Mazuza; Giacobbe, Benedetto; Giagu, Stefano; Giannetti, Paola; Gibbard, Bruce; Gibson, Stephen; Gignac, Matthew; Gilchriese, Murdock; Gillam, Thomas; Gillberg, Dag; Gilles, Geoffrey; Gingrich, Douglas; Giokaris, Nikos; Giordani, MarioPaolo; Giorgi, Filippo Maria; Giorgi, Francesco Michelangelo; Giraud, Pierre-Francois; Giromini, Paolo; Giugni, Danilo; Giuli, Francesco; Giuliani, Claudia; Giulini, Maddalena; Gjelsten, Børge Kile; Gkaitatzis, Stamatios; Gkialas, Ioannis; Gkougkousis, Evangelos Leonidas; Gladilin, Leonid; Glasman, Claudia; Glatzer, Julian; Glaysher, Paul; Glazov, Alexandre; Goblirsch-Kolb, Maximilian; Godlewski, Jan; Goldfarb, Steven; Golling, Tobias; Golubkov, Dmitry; Gomes, Agostinho; Gonçalo, Ricardo; Goncalves Pinto Firmino Da Costa, Joao; Gonella, Laura; Gongadze, Alexi; González de la Hoz, Santiago; Gonzalez Parra, Garoe; Gonzalez-Sevilla, Sergio; Goossens, Luc; Gorbounov, Petr Andreevich; Gordon, Howard; Gorelov, Igor; Gorini, Benedetto; Gorini, Edoardo; Gorišek, Andrej; Gornicki, Edward; Goshaw, Alfred; Gössling, Claus; Gostkin, Mikhail Ivanovitch; Goudet, Christophe Raymond; Goujdami, Driss; Goussiou, Anna; Govender, Nicolin; Gozani, Eitan; Graber, Lars; Grabowska-Bold, Iwona; Gradin, Per Olov Joakim; Grafström, Per; Gramling, Johanna; Gramstad, Eirik; Grancagnolo, Sergio; Gratchev, Vadim; Gray, Heather; Graziani, Enrico; Greenwood, Zeno Dixon; Grefe, Christian; Gregersen, Kristian; Gregor, Ingrid-Maria; Grenier, Philippe; Grevtsov, Kirill; Griffiths, Justin; Grillo, Alexander; Grimm, Kathryn; Grinstein, Sebastian; Gris, Philippe Luc Yves; Grivaz, Jean-Francois; Groh, Sabrina; Grohs, Johannes Philipp; Gross, Eilam; Grosse-Knetter, Joern; Grossi, Giulio Cornelio; Grout, Zara Jane; Guan, Liang; Guan, Wen; Guenther, Jaroslav; Guescini, Francesco; Guest, Daniel; Gueta, Orel; Guido, Elisa; Guillemin, Thibault; Guindon, Stefan; Gul, Umar; Gumpert, Christian; Guo, Jun; Guo, Yicheng; Gupta, Shaun; Gustavino, Giuliano; Gutierrez, Phillip; Gutierrez Ortiz, Nicolas Gilberto; Gutschow, Christian; Guyot, Claude; Gwenlan, Claire; Gwilliam, Carl; Haas, Andy; Haber, Carl; Hadavand, Haleh Khani; Haddad, Nacim; Hadef, Asma; Haefner, Petra; Hageböck, Stephan; Hajduk, Zbigniew; Hakobyan, Hrachya; Haleem, Mahsana; Haley, Joseph; Hall, David; Halladjian, Garabed; Hallewell, Gregory David; Hamacher, Klaus; Hamal, Petr; Hamano, Kenji; Hamilton, Andrew; Hamity, Guillermo Nicolas; Hamnett, Phillip George; Han, Liang; Hanagaki, Kazunori; Hanawa, Keita; Hance, Michael; Haney, Bijan; Hanke, Paul; Hanna, Remie; Hansen, Jørgen Beck; Hansen, Jorn Dines; Hansen, Maike Christina; Hansen, Peter Henrik; Hara, Kazuhiko; Hard, Andrew; Harenberg, Torsten; Hariri, Faten; Harkusha, Siarhei; Harrington, Robert; Harrison, Paul Fraser; Hartjes, Fred; Hasegawa, Makoto; Hasegawa, Yoji; Hasib, A; Hassani, Samira; Haug, Sigve; Hauser, Reiner; Hauswald, Lorenz; Havranek, Miroslav; Hawkes, Christopher; Hawkings, Richard John; Hawkins, Anthony David; Hayden, Daniel; Hays, Chris; Hays, Jonathan Michael; Hayward, Helen; Haywood, Stephen; Head, Simon; Heck, Tobias; Hedberg, Vincent; Heelan, Louise; Heim, Sarah; Heim, Timon; Heinemann, Beate; Heinrich, Jochen Jens; Heinrich, Lukas; Heinz, Christian; Hejbal, Jiri; Helary, Louis; Hellman, Sten; Helsens, Clement; Henderson, James; Henderson, Robert; Heng, Yang; Henkelmann, Steffen; Henriques Correia, Ana Maria; Henrot-Versille, Sophie; Herbert, Geoffrey Henry; Hernández Jiménez, Yesenia; Herten, Gregor; Hertenberger, Ralf; Hervas, Luis; Hesketh, Gavin Grant; Hessey, Nigel; Hetherly, Jeffrey Wayne; Hickling, Robert; Higón-Rodriguez, Emilio; Hill, Ewan; Hill, John; Hiller, Karl Heinz; Hillier, Stephen; Hinchliffe, Ian; Hines, Elizabeth; Hinman, Rachel Reisner; Hirose, Minoru; Hirschbuehl, Dominic; Hobbs, John; Hod, Noam; Hodgkinson, Mark; Hodgson, Paul; Hoecker, Andreas; Hoeferkamp, Martin; Hoenig, Friedrich; Hohlfeld, Marc; Hohn, David; Holmes, Tova Ray; Homann, Michael; Hong, Tae Min; Hooberman, Benjamin Henry; Hopkins, Walter; Horii, Yasuyuki; Horton, Arthur James; Hostachy, Jean-Yves; Hou, Suen; Hoummada, Abdeslam; Howard, Jacob; Howarth, James; Hrabovsky, Miroslav; Hristova, Ivana; Hrivnac, Julius; Hryn'ova, Tetiana; Hrynevich, Aliaksei; Hsu, Catherine; Hsu, Pai-hsien Jennifer; Hsu, Shih-Chieh; Hu, Diedi; Hu, Qipeng; Huang, Yanping; Hubacek, Zdenek; Hubaut, Fabrice; Huegging, Fabian; Huffman, Todd Brian; Hughes, Emlyn; Hughes, Gareth; Huhtinen, Mika; Hülsing, Tobias Alexander; Huseynov, Nazim; Huston, Joey; Huth, John; Iacobucci, Giuseppe; Iakovidis, Georgios; Ibragimov, Iskander; Iconomidou-Fayard, Lydia; Ideal, Emma; Idrissi, Zineb; Iengo, Paolo; Igonkina, Olga; Iizawa, Tomoya; Ikegami, Yoichi; Ikeno, Masahiro; Ilchenko, Iurii; Iliadis, Dimitrios; Ilic, Nikolina; Ince, Tayfun; Introzzi, Gianluca; Ioannou, Pavlos; Iodice, Mauro; Iordanidou, Kalliopi; Ippolito, Valerio; Irles Quiles, Adrian; Isaksson, Charlie; Ishino, Masaya; Ishitsuka, Masaki; Ishmukhametov, Renat; Issever, Cigdem; Istin, Serhat; Ito, Fumiaki; Iturbe Ponce, Julia Mariana; Iuppa, Roberto; Ivarsson, Jenny; Iwanski, Wieslaw; Iwasaki, Hiroyuki; Izen, Joseph; Izzo, Vincenzo; Jabbar, Samina; Jackson, Brett; Jackson, Matthew; Jackson, Paul; Jain, Vivek; Jakobi, Katharina Bianca; Jakobs, Karl; Jakobsen, Sune; Jakoubek, Tomas; Jamin, David Olivier; Jana, Dilip; Jansen, Eric; Jansky, Roland; Janssen, Jens; Janus, Michel; Jarlskog, Göran; Javadov, Namig; Javůrek, Tomáš; Jeanneau, Fabien; Jeanty, Laura; Jejelava, Juansher; Jeng, Geng-yuan; Jennens, David; Jenni, Peter; Jentzsch, Jennifer; Jeske, Carl; Jézéquel, Stéphane; Ji, Haoshuang; Jia, Jiangyong; Jiang, Hai; Jiang, Yi; Jiggins, Stephen; Jimenez Pena, Javier; Jin, Shan; Jinaru, Adam; Jinnouchi, Osamu; Johansson, Per; Johns, Kenneth; Johnson, William Joseph; Jon-And, Kerstin; Jones, Graham; Jones, Roger; Jones, Sarah; Jones, Tim; Jongmanns, Jan; Jorge, Pedro; Jovicevic, Jelena; Ju, Xiangyang; Juste Rozas, Aurelio; Köhler, Markus Konrad; Kaczmarska, Anna; Kado, Marumi; Kagan, Harris; Kagan, Michael; Kahn, Sebastien Jonathan; Kajomovitz, Enrique; Kalderon, Charles William; Kaluza, Adam; Kama, Sami; Kamenshchikov, Andrey; Kanaya, Naoko; Kaneti, Steven; Kantserov, Vadim; Kanzaki, Junichi; Kaplan, Benjamin; Kaplan, Laser Seymour; Kapliy, Anton; Kar, Deepak; Karakostas, Konstantinos; Karamaoun, Andrew; Karastathis, Nikolaos; Kareem, Mohammad Jawad; Karentzos, Efstathios; Karnevskiy, Mikhail; Karpov, Sergey; Karpova, Zoya; Karthik, Krishnaiyengar; Kartvelishvili, Vakhtang; Karyukhin, Andrey; Kasahara, Kota; Kashif, Lashkar; Kass, Richard; Kastanas, Alex; Kataoka, Yousuke; Kato, Chikuma; Katre, Akshay; Katzy, Judith; Kawagoe, Kiyotomo; Kawamoto, Tatsuo; Kawamura, Gen; Kazama, Shingo; Kazanin, Vassili; Keeler, Richard; Kehoe, Robert; Keller, John; Kempster, Jacob Julian; Kentaro, Kawade; Keoshkerian, Houry; Kepka, Oldrich; Kerševan, Borut Paul; Kersten, Susanne; Keyes, Robert; Khalil-zada, Farkhad; Khandanyan, Hovhannes; Khanov, Alexander; Kharlamov, Alexey; Khoo, Teng Jian; Khovanskiy, Valery; Khramov, Evgeniy; Khubua, Jemal; Kido, Shogo; Kim, Hee Yeun; Kim, Shinhong; Kim, Young-Kee; Kimura, Naoki; Kind, Oliver Maria; King, Barry; King, Matthew; King, Samuel Burton; Kirk, Julie; Kiryunin, Andrey; Kishimoto, Tomoe; Kisielewska, Danuta; Kiss, Florian; Kiuchi, Kenji; Kivernyk, Oleh; Kladiva, Eduard; Klein, Matthew Henry; Klein, Max; Klein, Uta; Kleinknecht, Konrad; Klimek, Pawel; Klimentov, Alexei; Klingenberg, Reiner; Klinger, Joel Alexander; Klioutchnikova, Tatiana; Kluge, Eike-Erik; Kluit, Peter; Kluth, Stefan; Knapik, Joanna; Kneringer, Emmerich; Knoops, Edith; Knue, Andrea; Kobayashi, Aine; Kobayashi, Dai; Kobayashi, Tomio; Kobel, Michael; Kocian, Martin; Kodys, Peter; Koffas, Thomas; Koffeman, Els; Kogan, Lucy Anne; Koi, Tatsumi; Kolanoski, Hermann; Kolb, Mathis; Koletsou, Iro; Komar, Aston; Komori, Yuto; Kondo, Takahiko; Kondrashova, Nataliia; Köneke, Karsten; König, Adriaan; Kono, Takanori; Konoplich, Rostislav; Konstantinidis, Nikolaos; Kopeliansky, Revital; Koperny, Stefan; Köpke, Lutz; Kopp, Anna Katharina; Korcyl, Krzysztof; Kordas, Kostantinos; Korn, Andreas; Korol, Aleksandr; Korolkov, Ilya; Korolkova, Elena; Kortner, Oliver; Kortner, Sandra; Kosek, Tomas; Kostyukhin, Vadim; Kotwal, Ashutosh; Kourkoumeli-Charalampidi, Athina; Kourkoumelis, Christine; Kouskoura, Vasiliki; Koutsman, Alex; Kowalewska, Anna Bozena; Kowalewski, Robert Victor; Kowalski, Tadeusz; Kozanecki, Witold; Kozhin, Anatoly; Kramarenko, Viktor; Kramberger, Gregor; Krasnopevtsev, Dimitriy; Krasny, Mieczyslaw Witold; Krasznahorkay, Attila; Kraus, Jana; Kravchenko, Anton; Kretz, Moritz; Kretzschmar, Jan; Kreutzfeldt, Kristof; Krieger, Peter; Krizka, Karol; Kroeninger, Kevin; Kroha, Hubert; Kroll, Joe; Kroseberg, Juergen; Krstic, Jelena; Kruchonak, Uladzimir; Krüger, Hans; Krumnack, Nils; Kruse, Amanda; Kruse, Mark; Kruskal, Michael; Kubota, Takashi; Kucuk, Hilal; Kuday, Sinan; Kuechler, Jan Thomas; Kuehn, Susanne; Kugel, Andreas; Kuger, Fabian; Kuhl, Andrew; Kuhl, Thorsten; Kukhtin, Victor; Kukla, Romain; Kulchitsky, Yuri; Kuleshov, Sergey; Kuna, Marine; Kunigo, Takuto; Kupco, Alexander; Kurashige, Hisaya; Kurochkin, Yurii; Kus, Vlastimil; Kuwertz, Emma Sian; Kuze, Masahiro; Kvita, Jiri; Kwan, Tony; Kyriazopoulos, Dimitrios; La Rosa, Alessandro; La Rosa Navarro, Jose Luis; La Rotonda, Laura; Lacasta, Carlos; Lacava, Francesco; Lacey, James; Lacker, Heiko; Lacour, Didier; Lacuesta, Vicente Ramón; Ladygin, Evgueni; Lafaye, Remi; Laforge, Bertrand; Lagouri, Theodota; Lai, Stanley; Lammers, Sabine; Lampl, Walter; Lançon, Eric; Landgraf, Ulrich; Landon, Murrough; Lang, Valerie Susanne; Lange, J örn Christian; Lankford, Andrew; Lanni, Francesco; Lantzsch, Kerstin; Lanza, Agostino; Laplace, Sandrine; Lapoire, Cecile; Laporte, Jean-Francois; Lari, Tommaso; Lasagni Manghi, Federico; Lassnig, Mario; Laurelli, Paolo; Lavrijsen, Wim; Law, Alexander; Laycock, Paul; Lazovich, Tomo; Lazzaroni, Massimo; Le Dortz, Olivier; Le Guirriec, Emmanuel; Le Menedeu, Eve; Le Quilleuc, Eloi; LeBlanc, Matthew Edgar; LeCompte, Thomas; Ledroit-Guillon, Fabienne Agnes Marie; Lee, Claire Alexandra; Lee, Shih-Chang; Lee, Lawrence; Lefebvre, Guillaume; Lefebvre, Michel; Legger, Federica; Leggett, Charles; Lehan, Allan; Lehmann Miotto, Giovanna; Lei, Xiaowen; Leight, William Axel; Leisos, Antonios; Leister, Andrew Gerard; Leite, Marco Aurelio Lisboa; Leitner, Rupert; Lellouch, Daniel; Lemmer, Boris; Leney, Katharine; Lenz, Tatjana; Lenzi, Bruno; Leone, Robert; Leone, Sandra; Leonidopoulos, Christos; Leontsinis, Stefanos; Lerner, Giuseppe; Leroy, Claude; Lesage, Arthur; Lester, Christopher; Levchenko, Mikhail; Levêque, Jessica; Levin, Daniel; Levinson, Lorne; Levy, Mark; Leyko, Agnieszka; Leyton, Michael; Li, Bing; Li, Haifeng; Li, Ho Ling; Li, Lei; Li, Liang; Li, Qi; Li, Shu; Li, Xingguo; Li, Yichen; Liang, Zhijun; Liao, Hongbo; Liberti, Barbara; Liblong, Aaron; Lichard, Peter; Lie, Ki; Liebal, Jessica; Liebig, Wolfgang; Limbach, Christian; Limosani, Antonio; Lin, Simon; Lin, Tai-Hua; Lindquist, Brian Edward; Lipeles, Elliot; Lipniacka, Anna; Lisovyi, Mykhailo; Liss, Tony; Lissauer, David; Lister, Alison; Litke, Alan; Liu, Bo; Liu, Dong; Liu, Hao; Liu, Hongbin; Liu, Jian; Liu, Jianbei; Liu, Kun; Liu, Lulu; Liu, Miaoyuan; Liu, Minghui; Liu, Yanlin; Liu, Yanwen; Livan, Michele; Lleres, Annick; Llorente Merino, Javier; Lloyd, Stephen; Lo Sterzo, Francesco; Lobodzinska, Ewelina; Loch, Peter; Lockman, William; Loebinger, Fred; Loevschall-Jensen, Ask Emil; Loew, Kevin Michael; Loginov, Andrey; Lohse, Thomas; Lohwasser, Kristin; Lokajicek, Milos; Long, Brian Alexander; Long, Jonathan David; Long, Robin Eamonn; Longo, Luigi; Looper, Kristina Anne; Lopes, Lourenco; Lopez Mateos, David; Lopez Paredes, Brais; Lopez Paz, Ivan; Lopez Solis, Alvaro; Lorenz, Jeanette; Lorenzo Martinez, Narei; Losada, Marta; Lösel, Philipp Jonathan; Lou, XinChou; Lounis, Abdenour; Love, Jeremy; Love, Peter; Lu, Haonan; Lu, Nan; Lubatti, Henry; Luci, Claudio; Lucotte, Arnaud; Luedtke, Christian; Luehring, Frederick; Lukas, Wolfgang; Luminari, Lamberto; Lundberg, Olof; Lund-Jensen, Bengt; Lynn, David; Lysak, Roman; Lytken, Else; Lyubushkin, Vladimir; Ma, Hong; Ma, Lian Liang; Ma, Yanhui; Maccarrone, Giovanni; Macchiolo, Anna; Macdonald, Calum Michael; Maček, Boštjan; Machado Miguens, Joana; Madaffari, Daniele; Madar, Romain; Maddocks, Harvey Jonathan; Mader, Wolfgang; Madsen, Alexander; Maeda, Junpei; Maeland, Steffen; Maeno, Tadashi; Maevskiy, Artem; Magradze, Erekle; Mahlstedt, Joern; Maiani, Camilla; Maidantchik, Carmen; Maier, Andreas Alexander; Maier, Thomas; Maio, Amélia; Majewski, Stephanie; Makida, Yasuhiro; Makovec, Nikola; Malaescu, Bogdan; Malecki, Pawel; Maleev, Victor; Malek, Fairouz; Mallik, Usha; Malon, David; Malone, Caitlin; Maltezos, Stavros; Malyukov, Sergei; Mamuzic, Judita; Mancini, Giada; Mandelli, Beatrice; Mandelli, Luciano; Mandić, Igor; Maneira, José; Manhaes de Andrade Filho, Luciano; Manjarres Ramos, Joany; Mann, Alexander; Mansoulie, Bruno; Mantifel, Rodger; Mantoani, Matteo; Manzoni, Stefano; Mapelli, Livio; Marceca, Gino; March, Luis; Marchiori, Giovanni; Marcisovsky, Michal; Marjanovic, Marija; Marley, Daniel; Marroquim, Fernando; Marsden, Stephen Philip; Marshall, Zach; Marti, Lukas Fritz; Marti-Garcia, Salvador; Martin, Brian Thomas; Martin, Tim; Martin, Victoria Jane; Martin dit Latour, Bertrand; Martinez, Mario; Martin-Haugh, Stewart; Martoiu, Victor Sorin; Martyniuk, Alex; Marx, Marilyn; Marzano, Francesco; Marzin, Antoine; Masetti, Lucia; Mashimo, Tetsuro; Mashinistov, Ruslan; Masik, Jiri; Maslennikov, Alexey; Massa, Ignazio; Massa, Lorenzo; Mastrandrea, Paolo; Mastroberardino, Anna; Masubuchi, Tatsuya; Mättig, Peter; Mattmann, Johannes; Maurer, Julien; Maxfield, Stephen; Maximov, Dmitriy; Mazini, Rachid; Mazza, Simone Michele; Mc Fadden, Neil Christopher; Mc Goldrick, Garrin; Mc Kee, Shawn Patrick; McCarn, Allison; McCarthy, Robert; McCarthy, Tom; McClymont, Laurie; McFarlane, Kenneth; Mcfayden, Josh; Mchedlidze, Gvantsa; McMahon, Steve; McPherson, Robert; Medinnis, Michael; Meehan, Samuel; Mehlhase, Sascha; Mehta, Andrew; Meier, Karlheinz; Meineck, Christian; Meirose, Bernhard; Mellado Garcia, Bruce Rafael; Meloni, Federico; Mengarelli, Alberto; Menke, Sven; Meoni, Evelin; Mercurio, Kevin Michael; Mergelmeyer, Sebastian; Mermod, Philippe; Merola, Leonardo; Meroni, Chiara; Merritt, Frank; Messina, Andrea; Metcalfe, Jessica; Mete, Alaettin Serhan; Meyer, Carsten; Meyer, Christopher; Meyer, Jean-Pierre; Meyer, Jochen; Meyer Zu Theenhausen, Hanno; Middleton, Robin; Miglioranzi, Silvia; Mijović, Liza; Mikenberg, Giora; Mikestikova, Marcela; Mikuž, Marko; Milesi, Marco; Milic, Adriana; Miller, David; Mills, Corrinne; Milov, Alexander; Milstead, David; Minaenko, Andrey; Minami, Yuto; Minashvili, Irakli; Mincer, Allen; Mindur, Bartosz; Mineev, Mikhail; Ming, Yao; Mir, Lluisa-Maria; Mistry, Khilesh; Mitani, Takashi; Mitrevski, Jovan; Mitsou, Vasiliki A; Miucci, Antonio; Miyagawa, Paul; Mjörnmark, Jan-Ulf; Moa, Torbjoern; Mochizuki, Kazuya; Mohapatra, Soumya; Mohr, Wolfgang; Molander, Simon; Moles-Valls, Regina; Monden, Ryutaro; Mondragon, Matthew Craig; Mönig, Klaus; Monk, James; Monnier, Emmanuel; Montalbano, Alyssa; Montejo Berlingen, Javier; Monticelli, Fernando; Monzani, Simone; Moore, Roger; Morange, Nicolas; Moreno, Deywis; Moreno Llácer, María; Morettini, Paolo; Mori, Daniel; Mori, Tatsuya; Morii, Masahiro; Morinaga, Masahiro; Morisbak, Vanja; Moritz, Sebastian; Morley, Anthony Keith; Mornacchi, Giuseppe; Morris, John; Mortensen, Simon Stark; Morvaj, Ljiljana; Mosidze, Maia; Moss, Josh; Motohashi, Kazuki; Mount, Richard; Mountricha, Eleni; Mouraviev, Sergei; Moyse, Edward; Muanza, Steve; Mudd, Richard; Mueller, Felix; Mueller, James; Mueller, Ralph Soeren Peter; Mueller, Thibaut; Muenstermann, Daniel; Mullen, Paul; Mullier, Geoffrey; Munoz Sanchez, Francisca Javiela; Murillo Quijada, Javier Alberto; Murray, Bill; Musheghyan, Haykuhi; Muskinja, Miha; Myagkov, Alexey; Myska, Miroslav; Nachman, Benjamin Philip; Nackenhorst, Olaf; Nadal, Jordi; Nagai, Koichi; Nagai, Ryo; Nagano, Kunihiro; Nagasaka, Yasushi; Nagata, Kazuki; Nagel, Martin; Nagy, Elemer; Nairz, Armin Michael; Nakahama, Yu; Nakamura, Koji; Nakamura, Tomoaki; Nakano, Itsuo; Namasivayam, Harisankar; Naranjo Garcia, Roger Felipe; Narayan, Rohin; Narrias Villar, Daniel Isaac; Naryshkin, Iouri; Naumann, Thomas; Navarro, Gabriela; Nayyar, Ruchika; Neal, Homer; Nechaeva, Polina; Neep, Thomas James; Nef, Pascal Daniel; Negri, Andrea; Negrini, Matteo; Nektarijevic, Snezana; Nellist, Clara; Nelson, Andrew; Nemecek, Stanislav; Nemethy, Peter; Nepomuceno, Andre Asevedo; Nessi, Marzio; Neubauer, Mark; Neumann, Manuel; Neves, Ricardo; Nevski, Pavel; Newman, Paul; Nguyen, Duong Hai; Nickerson, Richard; Nicolaidou, Rosy; Nicquevert, Bertrand; Nielsen, Jason; Nikiforov, Andriy; Nikolaenko, Vladimir; Nikolic-Audit, Irena; Nikolopoulos, Konstantinos; Nilsen, Jon Kerr; Nilsson, Paul; Ninomiya, Yoichi; Nisati, Aleandro; Nisius, Richard; Nobe, Takuya; Nodulman, Lawrence; Nomachi, Masaharu; Nomidis, Ioannis; Nooney, Tamsin; Norberg, Scarlet; Nordberg, Markus; Norjoharuddeen, Nurfikri; Novgorodova, Olga; Nowak, Sebastian; Nozaki, Mitsuaki; Nozka, Libor; Ntekas, Konstantinos; Nurse, Emily; Nuti, Francesco; O'grady, Fionnbarr; O'Neil, Dugan; O'Rourke, Abigail Alexandra; O'Shea, Val; Oakham, Gerald; Oberlack, Horst; Obermann, Theresa; Ocariz, Jose; Ochi, Atsuhiko; Ochoa, Ines; Ochoa-Ricoux, Juan Pedro; Oda, Susumu; Odaka, Shigeru; Ogren, Harold; Oh, Alexander; Oh, Seog; Ohm, Christian; Ohman, Henrik; Oide, Hideyuki; Okawa, Hideki; Okumura, Yasuyuki; Okuyama, Toyonobu; Olariu, Albert; Oleiro Seabra, Luis Filipe; Olivares Pino, Sebastian Andres; Oliveira Damazio, Denis; Olszewski, Andrzej; Olszowska, Jolanta; Onofre, António; Onogi, Kouta; Onyisi, Peter; Oram, Christopher; Oreglia, Mark; Oren, Yona; Orestano, Domizia; Orlando, Nicola; Orr, Robert; Osculati, Bianca; Ospanov, Rustem; Otero y Garzon, Gustavo; Otono, Hidetoshi; Ouchrif, Mohamed; Ould-Saada, Farid; Ouraou, Ahmimed; Oussoren, Koen Pieter; Ouyang, Qun; Ovcharova, Ana; Owen, Mark; Owen, Rhys Edward; Ozcan, Veysi Erkcan; Ozturk, Nurcan; Pachal, Katherine; Pacheco Pages, Andres; Padilla Aranda, Cristobal; Pagáčová, Martina; Pagan Griso, Simone; Paige, Frank; Pais, Preema; Pajchel, Katarina; Palacino, Gabriel; Palestini, Sandro; Palka, Marek; Pallin, Dominique; Palm, Marcus; Palma, Alberto; Panagiotopoulou, Evgenia; Pandini, Carlo Enrico; Panduro Vazquez, William; Pani, Priscilla; Panitkin, Sergey; Pantea, Dan; Paolozzi, Lorenzo; Papadopoulou, Theodora; Papageorgiou, Konstantinos; Paramonov, Alexander; Paredes Hernandez, Daniela; Parker, Adam Jackson; Parker, Michael Andrew; Parker, Kerry Ann; Parodi, Fabrizio; Parsons, John; Parzefall, Ulrich; Pascuzzi, Vincent; Pasqualucci, Enrico; Passaggio, Stefano; Pastore, Fernanda; Pastore, Francesca; Pásztor, Gabriella; Pataraia, Sophio; Patel, Nikhul; Pater, Joleen; Pauly, Thilo; Pearce, James; Pearson, Benjamin; Pedersen, Lars Egholm; Pedersen, Maiken; Pedraza Lopez, Sebastian; Pedro, Rute; Peleganchuk, Sergey; Pelikan, Daniel; Penc, Ondrej; Peng, Cong; Peng, Haiping; Penwell, John; Peralva, Bernardo; Perego, Marta Maria; Perepelitsa, Dennis; Perez Codina, Estel; Perini, Laura; Pernegger, Heinz; Perrella, Sabrina; Peschke, Richard; Peshekhonov, Vladimir; Peters, Krisztian; Peters, Yvonne; Petersen, Brian; Petersen, Troels; Petit, Elisabeth; Petridis, Andreas; Petridou, Chariclia; Petroff, Pierre; Petrolo, Emilio; Petrov, Mariyan; Petrucci, Fabrizio; Pettersson, Nora Emilia; Peyaud, Alan; Pezoa, Raquel; Phillips, Peter William; Piacquadio, Giacinto; Pianori, Elisabetta; Picazio, Attilio; Piccaro, Elisa; Piccinini, Maurizio; Pickering, Mark Andrew; Piegaia, Ricardo; Pilcher, James; Pilkington, Andrew; Pin, Arnaud Willy J; Pina, João Antonio; Pinamonti, Michele; Pinfold, James; Pingel, Almut; Pires, Sylvestre; Pirumov, Hayk; Pitt, Michael; Plazak, Lukas; Pleier, Marc-Andre; Pleskot, Vojtech; Plotnikova, Elena; Plucinski, Pawel; Pluth, Daniel; Poettgen, Ruth; Poggioli, Luc; Pohl, David-leon; Polesello, Giacomo; Poley, Anne-luise; Policicchio, Antonio; Polifka, Richard; Polini, Alessandro; Pollard, Christopher Samuel; Polychronakos, Venetios; Pommès, Kathy; Pontecorvo, Ludovico; Pope, Bernard; Popeneciu, Gabriel Alexandru; Popovic, Dragan; Poppleton, Alan; Pospisil, Stanislav; Potamianos, Karolos; Potrap, Igor; Potter, Christina; Potter, Christopher; Poulard, Gilbert; Poveda, Joaquin; Pozdnyakov, Valery; Pozo Astigarraga, Mikel Eukeni; Pralavorio, Pascal; Pranko, Aliaksandr; Prell, Soeren; Price, Darren; Price, Lawrence; Primavera, Margherita; Prince, Sebastien; Proissl, Manuel; Prokofiev, Kirill; Prokoshin, Fedor; Protopopescu, Serban; Proudfoot, James; Przybycien, Mariusz; Puddu, Daniele; Puldon, David; Purohit, Milind; Puzo, Patrick; Qian, Jianming; Qin, Gang; Qin, Yang; Quadt, Arnulf; Quayle, William; Queitsch-Maitland, Michaela; Quilty, Donnchadha; Raddum, Silje; Radeka, Veljko; Radescu, Voica; Radhakrishnan, Sooraj Krishnan; Radloff, Peter; Rados, Pere; Ragusa, Francesco; Rahal, Ghita; Raine, John Andrew; Rajagopalan, Srinivasan; Rammensee, Michael; Rangel-Smith, Camila; Ratti, Maria Giulia; Rauscher, Felix; Rave, Stefan; Ravenscroft, Thomas; Raymond, Michel; Read, Alexander Lincoln; Readioff, Nathan Peter; Rebuzzi, Daniela; Redelbach, Andreas; Redlinger, George; Reece, Ryan; Reeves, Kendall; Rehnisch, Laura; Reichert, Joseph; Reisin, Hernan; Rembser, Christoph; Ren, Huan; Rescigno, Marco; Resconi, Silvia; Rezanova, Olga; Reznicek, Pavel; Rezvani, Reyhaneh; Richter, Robert; Richter, Stefan; Richter-Was, Elzbieta; Ricken, Oliver; Ridel, Melissa; Rieck, Patrick; Riegel, Christian Johann; Rieger, Julia; Rifki, Othmane; Rijssenbeek, Michael; Rimoldi, Adele; Rinaldi, Lorenzo; Ristić, Branislav; Ritsch, Elmar; Riu, Imma; Rizatdinova, Flera; Rizvi, Eram; Rizzi, Chiara; Robertson, Steven; Robichaud-Veronneau, Andree; Robinson, Dave; Robinson, James; Robson, Aidan; Roda, Chiara; Rodina, Yulia; Rodriguez Perez, Andrea; Rodriguez Rodriguez, Daniel; Roe, Shaun; Rogan, Christopher Sean; Røhne, Ole; Romaniouk, Anatoli; Romano, Marino; Romano Saez, Silvestre Marino; Romero Adam, Elena; Rompotis, Nikolaos; Ronzani, Manfredi; Roos, Lydia; Ros, Eduardo; Rosati, Stefano; Rosbach, Kilian; Rose, Peyton; Rosenthal, Oliver; Rossetti, Valerio; Rossi, Elvira; Rossi, Leonardo Paolo; Rosten, Jonatan; Rosten, Rachel; Rotaru, Marina; Roth, Itamar; Rothberg, Joseph; Rousseau, David; Royon, Christophe; Rozanov, Alexandre; Rozen, Yoram; Ruan, Xifeng; Rubbo, Francesco; Rubinskiy, Igor; Rud, Viacheslav; Rudolph, Matthew Scott; Rühr, Frederik; Ruiz-Martinez, Aranzazu; Rurikova, Zuzana; Rusakovich, Nikolai; Ruschke, Alexander; Russell, Heather; Rutherfoord, John; Ruthmann, Nils; Ryabov, Yury; Rybar, Martin; Rybkin, Grigori; Ryu, Soo; Ryzhov, Andrey; Saavedra, Aldo; Sabato, Gabriele; Sacerdoti, Sabrina; Sadrozinski, Hartmut; Sadykov, Renat; Safai Tehrani, Francesco; Saha, Puja; Sahinsoy, Merve; Saimpert, Matthias; Saito, Tomoyuki; Sakamoto, Hiroshi; Sakurai, Yuki; Salamanna, Giuseppe; Salamon, Andrea; Salazar Loyola, Javier Esteban; Salek, David; Sales De Bruin, Pedro Henrique; Salihagic, Denis; Salnikov, Andrei; Salt, José; Salvatore, Daniela; Salvatore, Pasquale Fabrizio; Salvucci, Antonio; Salzburger, Andreas; Sammel, Dirk; Sampsonidis, Dimitrios; Sanchez, Arturo; Sánchez, Javier; Sanchez Martinez, Victoria; Sandaker, Heidi; Sandbach, Ruth Laura; Sander, Heinz Georg; Sanders, Michiel; Sandhoff, Marisa; Sandoval, Carlos; Sandstroem, Rikard; Sankey, Dave; Sannino, Mario; Sansoni, Andrea; Santoni, Claudio; Santonico, Rinaldo; Santos, Helena; Santoyo Castillo, Itzebelt; Sapp, Kevin; Sapronov, Andrey; Saraiva, João; Sarrazin, Bjorn; Sasaki, Osamu; Sasaki, Yuichi; Sato, Koji; Sauvage, Gilles; Sauvan, Emmanuel; Savage, Graham; Savard, Pierre; Sawyer, Craig; Sawyer, Lee; Saxon, James; Sbarra, Carla; Sbrizzi, Antonio; Scanlon, Tim; Scannicchio, Diana; Scarcella, Mark; Scarfone, Valerio; Schaarschmidt, Jana; Schacht, Peter; Schaefer, Douglas; Schaefer, Ralph; Schaeffer, Jan; Schaepe, Steffen; Schaetzel, Sebastian; Schäfer, Uli; Schaffer, Arthur; Schaile, Dorothee; Schamberger, R Dean; Scharf, Veit; Schegelsky, Valery; Scheirich, Daniel; Schernau, Michael; Schiavi, Carlo; Schillo, Christian; Schioppa, Marco; Schlenker, Stefan; Schmieden, Kristof; Schmitt, Christian; Schmitt, Stefan; Schmitz, Simon; Schneider, Basil; Schnellbach, Yan Jie; Schnoor, Ulrike; Schoeffel, Laurent; Schoening, Andre; Schoenrock, Bradley Daniel; Schopf, Elisabeth; Schorlemmer, Andre Lukas; Schott, Matthias; Schovancova, Jaroslava; Schramm, Steven; Schreyer, Manuel; Schuh, Natascha; Schultens, Martin Johannes; Schultz-Coulon, Hans-Christian; Schulz, Holger; Schumacher, Markus; Schumm, Bruce; Schune, Philippe; Schwanenberger, Christian; Schwartzman, Ariel; Schwarz, Thomas Andrew; Schwegler, Philipp; Schweiger, Hansdieter; Schwemling, Philippe; Schwienhorst, Reinhard; Schwindling, Jerome; Schwindt, Thomas; Sciolla, Gabriella; Scuri, Fabrizio; Scutti, Federico; Searcy, Jacob; Seema, Pienpen; Seidel, Sally; Seiden, Abraham; Seifert, Frank; Seixas, José; Sekhniaidze, Givi; Sekhon, Karishma; Sekula, Stephen; Seliverstov, Dmitry; Semprini-Cesari, Nicola; Serfon, Cedric; Serin, Laurent; Serkin, Leonid; Sessa, Marco; Seuster, Rolf; Severini, Horst; Sfiligoj, Tina; Sforza, Federico; Sfyrla, Anna; Shabalina, Elizaveta; Shaikh, Nabila Wahab; Shan, Lianyou; Shang, Ruo-yu; Shank, James; Shapiro, Marjorie; Shatalov, Pavel; Shaw, Kate; Shaw, Savanna Marie; Shcherbakova, Anna; Shehu, Ciwake Yusufu; Sherwood, Peter; Shi, Liaoshan; Shimizu, Shima; Shimmin, Chase Owen; Shimojima, Makoto; Shiyakova, Mariya; Shmeleva, Alevtina; Shoaleh Saadi, Diane; Shochet, Mel; Shojaii, Seyedruhollah; Shrestha, Suyog; Shulga, Evgeny; Shupe, Michael; Sicho, Petr; Sidebo, Per Edvin; Sidiropoulou, Ourania; Sidorov, Dmitri; Sidoti, Antonio; Siegert, Frank; Sijacki, Djordje; Silva, José; Silverstein, Samuel; Simak, Vladislav; Simard, Olivier; Simic, Ljiljana; Simion, Stefan; Simioni, Eduard; Simmons, Brinick; Simon, Dorian; Simon, Manuel; Sinervo, Pekka; Sinev, Nikolai; Sioli, Maximiliano; Siragusa, Giovanni; Sivoklokov, Serguei; Sjölin, Jörgen; Sjursen, Therese; Skinner, Malcolm Bruce; Skottowe, Hugh Philip; Skubic, Patrick; Slater, Mark; Slavicek, Tomas; Slawinska, Magdalena; Sliwa, Krzysztof; Slovak, Radim; Smakhtin, Vladimir; Smart, Ben; Smestad, Lillian; Smirnov, Sergei; Smirnov, Yury; Smirnova, Lidia; Smirnova, Oxana; Smith, Matthew; Smith, Russell; Smizanska, Maria; Smolek, Karel; Snesarev, Andrei; Snidero, Giacomo; Snyder, Scott; Sobie, Randall; Socher, Felix; Soffer, Abner; Soh, Dart-yin; Sokhrannyi, Grygorii; Solans Sanchez, Carlos; Solar, Michael; Soldatov, Evgeny; Soldevila, Urmila; Solodkov, Alexander; Soloshenko, Alexei; Solovyanov, Oleg; Solovyev, Victor; Sommer, Philip; Son, Hyungsuk; Song, Hong Ye; Sood, Alexander; Sopczak, Andre; Sopko, Vit; Sorin, Veronica; Sosa, David; Sotiropoulou, Calliope Louisa; Soualah, Rachik; Soukharev, Andrey; South, David; Sowden, Benjamin; Spagnolo, Stefania; Spalla, Margherita; Spangenberg, Martin; Spanò, Francesco; Sperlich, Dennis; Spettel, Fabian; Spighi, Roberto; Spigo, Giancarlo; Spiller, Laurence Anthony; Spousta, Martin; St Denis, Richard Dante; Stabile, Alberto; Stahlman, Jonathan; Stamen, Rainer; Stamm, Soren; Stanecka, Ewa; Stanek, Robert; Stanescu, Cristian; Stanescu-Bellu, Madalina; Stanitzki, Marcel Michael; Stapnes, Steinar; Starchenko, Evgeny; Stark, Giordon; Stark, Jan; Staroba, Pavel; Starovoitov, Pavel; Stärz, Steffen; Staszewski, Rafal; Steinberg, Peter; Stelzer, Bernd; Stelzer, Harald Joerg; Stelzer-Chilton, Oliver; Stenzel, Hasko; Stewart, Graeme; Stillings, Jan Andre; Stockton, Mark; Stoebe, Michael; Stoicea, Gabriel; Stolte, Philipp; Stonjek, Stefan; Stradling, Alden; Straessner, Arno; Stramaglia, Maria Elena; Strandberg, Jonas; Strandberg, Sara; Strandlie, Are; Strauss, Michael; Strizenec, Pavol; Ströhmer, Raimund; Strom, David; Stroynowski, Ryszard; Strubig, Antonia; Stucci, Stefania Antonia; Stugu, Bjarne; Styles, Nicholas Adam; Su, Dong; Su, Jun; Subramaniam, Rajivalochan; Suchek, Stanislav; Sugaya, Yorihito; Suk, Michal; Sulin, Vladimir; Sultansoy, Saleh; Sumida, Toshi; Sun, Siyuan; Sun, Xiaohu; Sundermann, Jan Erik; Suruliz, Kerim; Susinno, Giancarlo; Sutton, Mark; Suzuki, Shota; Svatos, Michal; Swiatlowski, Maximilian; Sykora, Ivan; Sykora, Tomas; Ta, Duc; Taccini, Cecilia; Tackmann, Kerstin; Taenzer, Joe; Taffard, Anyes; Tafirout, Reda; Taiblum, Nimrod; Takai, Helio; Takashima, Ryuichi; Takeda, Hiroshi; Takeshita, Tohru; Takubo, Yosuke; Talby, Mossadek; Talyshev, Alexey; Tam, Jason; Tan, Kong Guan; Tanaka, Junichi; Tanaka, Reisaburo; Tanaka, Shuji; Tannenwald, Benjamin Bordy; Tapia Araya, Sebastian; Tapprogge, Stefan; Tarem, Shlomit; Tartarelli, Giuseppe Francesco; Tas, Petr; Tasevsky, Marek; Tashiro, Takuya; Tassi, Enrico; Tavares Delgado, Ademar; Tayalati, Yahya; Taylor, Aaron; Taylor, Geoffrey; Taylor, Pierre Thor Elliot; Taylor, Wendy; Teischinger, Florian Alfred; Teixeira-Dias, Pedro; Temming, Kim Katrin; Temple, Darren; Ten Kate, Herman; Teng, Ping-Kun; Teoh, Jia Jian; Tepel, Fabian-Phillipp; Terada, Susumu; Terashi, Koji; Terron, Juan; Terzo, Stefano; Testa, Marianna; Teuscher, Richard; Theveneaux-Pelzer, Timothée; Thomas, Juergen; Thomas-Wilsker, Joshuha; Thompson, Emily; Thompson, Paul; Thompson, Ray; Thompson, Stan; Thomsen, Lotte Ansgaard; Thomson, Evelyn; Thomson, Mark; Tibbetts, Mark James; Ticse Torres, Royer Edson; Tikhomirov, Vladimir; Tikhonov, Yury; Timoshenko, Sergey; Tipton, Paul; Tisserant, Sylvain; Todome, Kazuki; Todorov, Theodore; Todorova-Nova, Sharka; Tojo, Junji; Tokár, Stanislav; Tokushuku, Katsuo; Tolley, Emma; Tomlinson, Lee; Tomoto, Makoto; Tompkins, Lauren; Toms, Konstantin; Tong, Baojia(Tony); Torrence, Eric; Torres, Heberth; Torró Pastor, Emma; Toth, Jozsef; Touchard, Francois; Tovey, Daniel; Trefzger, Thomas; Tricoli, Alessandro; Trigger, Isabel Marian; Trincaz-Duvoid, Sophie; Tripiana, Martin; Trischuk, William; Trocmé, Benjamin; Trofymov, Artur; Troncon, Clara; Trottier-McDonald, Michel; Trovatelli, Monica; Truong, Loan; Trzebinski, Maciej; Trzupek, Adam; Tseng, Jeffrey; Tsiareshka, Pavel; Tsipolitis, Georgios; Tsirintanis, Nikolaos; Tsiskaridze, Shota; Tsiskaridze, Vakhtang; Tskhadadze, Edisher; Tsui, Ka Ming; Tsukerman, Ilya; Tsulaia, Vakhtang; Tsuno, Soshi; Tsybychev, Dmitri; Tudorache, Alexandra; Tudorache, Valentina; Tuna, Alexander Naip; Tupputi, Salvatore; Turchikhin, Semen; Turecek, Daniel; Turgeman, Daniel; Turra, Ruggero; Turvey, Andrew John; Tuts, Michael; Tyndel, Mike; Ucchielli, Giulia; Ueda, Ikuo; Ueno, Ryuichi; Ughetto, Michael; Ukegawa, Fumihiko; Unal, Guillaume; Undrus, Alexander; Unel, Gokhan; Ungaro, Francesca; Unno, Yoshinobu; Unverdorben, Christopher; Urban, Jozef; Urquijo, Phillip; Urrejola, Pedro; Usai, Giulio; Usanova, Anna; Vacavant, Laurent; Vacek, Vaclav; Vachon, Brigitte; Valderanis, Chrysostomos; Valdes Santurio, Eduardo; Valencic, Nika; Valentinetti, Sara; Valero, Alberto; Valery, Loic; Valkar, Stefan; Vallecorsa, Sofia; Valls Ferrer, Juan Antonio; Van Den Wollenberg, Wouter; Van Der Deijl, Pieter; van der Geer, Rogier; van der Graaf, Harry; van Eldik, Niels; van Gemmeren, Peter; Van Nieuwkoop, Jacobus; van Vulpen, Ivo; van Woerden, Marius Cornelis; Vanadia, Marco; Vandelli, Wainer; Vanguri, Rami; Vaniachine, Alexandre; Vankov, Peter; Vardanyan, Gagik; Vari, Riccardo; Varnes, Erich; Varol, Tulin; Varouchas, Dimitris; Vartapetian, Armen; Varvell, Kevin; Vasquez, Jared Gregory; Vazeille, Francois; Vazquez Schroeder, Tamara; Veatch, Jason; Veloce, Laurelle Maria; Veloso, Filipe; Veneziano, Stefano; Ventura, Andrea; Venturi, Manuela; Venturi, Nicola; Venturini, Alessio; Vercesi, Valerio; Verducci, Monica; Verkerke, Wouter; Vermeulen, Jos; Vest, Anja; Vetterli, Michel; Viazlo, Oleksandr; Vichou, Irene; Vickey, Trevor; Vickey Boeriu, Oana Elena; Viehhauser, Georg; Viel, Simon; Vigani, Luigi; Vigne, Ralph; Villa, Mauro; Villaplana Perez, Miguel; Vilucchi, Elisabetta; Vincter, Manuella; Vinogradov, Vladimir; Vittori, Camilla; Vivarelli, Iacopo; Vlachos, Sotirios; Vlasak, Michal; Vogel, Marcelo; Vokac, Petr; Volpi, Guido; Volpi, Matteo; von der Schmitt, Hans; von Toerne, Eckhard; Vorobel, Vit; Vorobev, Konstantin; Vos, Marcel; Voss, Rudiger; Vossebeld, Joost; Vranjes, Nenad; Vranjes Milosavljevic, Marija; Vrba, Vaclav; Vreeswijk, Marcel; Vuillermet, Raphael; Vukotic, Ilija; Vykydal, Zdenek; Wagner, Peter; Wagner, Wolfgang; Wahlberg, Hernan; Wahrmund, Sebastian; Wakabayashi, Jun; Walder, James; Walker, Rodney; Walkowiak, Wolfgang; Wallangen, Veronica; Wang, Chao; Wang, Chao; Wang, Fuquan; Wang, Haichen; Wang, Hulin; Wang, Jike; Wang, Jin; Wang, Kuhan; Wang, Rui; Wang, Song-Ming; Wang, Tan; Wang, Tingting; Wang, Xiaoxiao; Wanotayaroj, Chaowaroj; Warburton, Andreas; Ward, Patricia; Wardrope, David Robert; Washbrook, Andrew; Watkins, Peter; Watson, Alan; Watson, Ian; Watson, Miriam; Watts, Gordon; Watts, Stephen; Waugh, Ben; Webb, Samuel; Weber, Michele; Weber, Stefan Wolf; Webster, Jordan S; Weidberg, Anthony; Weinert, Benjamin; Weingarten, Jens; Weiser, Christian; Weits, Hartger; Wells, Phillippa; Wenaus, Torre; Wengler, Thorsten; Wenig, Siegfried; Wermes, Norbert; Werner, Matthias; Werner, Per; Wessels, Martin; Wetter, Jeffrey; Whalen, Kathleen; Whallon, Nikola Lazar; Wharton, Andrew Mark; White, Andrew; White, Martin; White, Ryan; White, Sebastian; Whiteson, Daniel; Wickens, Fred; Wiedenmann, Werner; Wielers, Monika; Wienemann, Peter; Wiglesworth, Craig; Wiik-Fuchs, Liv Antje Mari; Wildauer, Andreas; Wilk, Fabian; Wilkens, Henric George; Williams, Hugh; Williams, Sarah; Willis, Christopher; Willocq, Stephane; Wilson, John; Wingerter-Seez, Isabelle; Winklmeier, Frank; Winston, Oliver James; Winter, Benedict Tobias; Wittgen, Matthias; Wittkowski, Josephine; Wollstadt, Simon Jakob; Wolter, Marcin Wladyslaw; Wolters, Helmut; Wosiek, Barbara; Wotschack, Jorg; Woudstra, Martin; Wozniak, Krzysztof; Wu, Mengqing; Wu, Miles; Wu, Sau Lan; Wu, Xin; Wu, Yusheng; Wyatt, Terry Richard; Wynne, Benjamin; Xella, Stefania; Xu, Da; Xu, Lailin; Yabsley, Bruce; Yacoob, Sahal; Yakabe, Ryota; Yamaguchi, Daiki; Yamaguchi, Yohei; Yamamoto, Akira; Yamamoto, Shimpei; Yamanaka, Takashi; Yamauchi, Katsuya; Yamazaki, Yuji; Yan, Zhen; Yang, Haijun; Yang, Hongtao; Yang, Yi; Yang, Zongchang; Yao, Weiming; Yap, Yee Chinn; Yasu, Yoshiji; Yatsenko, Elena; Yau Wong, Kaven Henry; Ye, Jingbo; Ye, Shuwei; Yeletskikh, Ivan; Yen, Andy L; Yildirim, Eda; Yorita, Kohei; Yoshida, Rikutaro; Yoshihara, Keisuke; Young, Charles; Young, Christopher John; Youssef, Saul; Yu, David Ren-Hwa; Yu, Jaehoon; Yu, Jiaming; Yu, Jie; Yuan, Li; Yuen, Stephanie P; Yusuff, Imran; Zabinski, Bartlomiej; Zaidan, Remi; Zaitsev, Alexander; Zakharchuk, Nataliia; Zalieckas, Justas; Zaman, Aungshuman; Zambito, Stefano; Zanello, Lucia; Zanzi, Daniele; Zeitnitz, Christian; Zeman, Martin; Zemla, Andrzej; Zeng, Jian Cong; Zeng, Qi; Zengel, Keith; Zenin, Oleg; Ženiš, Tibor; Zerwas, Dirk; Zhang, Dongliang; Zhang, Fangzhou; Zhang, Guangyi; Zhang, Huijun; Zhang, Jinlong; Zhang, Lei; Zhang, Rui; Zhang, Ruiqi; Zhang, Xueyao; Zhang, Zhiqing; Zhao, Xiandong; Zhao, Yongke; Zhao, Zhengguo; Zhemchugov, Alexey; Zhong, Jiahang; Zhou, Bing; Zhou, Chen; Zhou, Lei; Zhou, Li; Zhou, Mingliang; Zhou, Ning; Zhu, Cheng Guang; Zhu, Hongbo; Zhu, Junjie; Zhu, Yingchun; Zhuang, Xuai; Zhukov, Konstantin; Zibell, Andre; Zieminska, Daria; Zimine, Nikolai; Zimmermann, Christoph; Zimmermann, Stephanie; Zinonos, Zinonas; Zinser, Markus; Ziolkowski, Michael; Živković, Lidija; Zobernig, Georg; Zoccoli, Antonio; zur Nedden, Martin; Zurzolo, Giovanni; Zwalinski, Lukasz

    2016-05-20

    This paper discusses various observations on beam-induced and cosmic-ray backgrounds in the ATLAS detector during the LHC 2012 proton-proton run. Building on published results based on 2011 data, the correlations between background and residual pressure of the beam vacuum are revisited. Ghost charge evolution over 2012 and its role for backgrounds are evaluated. New methods to monitor ghost charge with beam-gas rates are presented and observations of LHC abort gap population by ghost charge are discussed in detail. Fake jets from colliding bunches and from ghost charge are analysed with improved methods, showing that ghost charge in individual radio-frequency buckets of the LHC can be resolved. Some results of two short periods of dedicated cosmic-ray background data-taking are shown; in particular cosmic-ray muon induced fake jet rates are compared to Monte Carlo simulations and to the fake jet rates from beam background. A thorough analysis of a particular LHC fill, where abnormally high background was obse...

  13. Dose error analysis for a scanned proton beam delivery system

    International Nuclear Information System (INIS)

    Coutrakon, G; Wang, N; Miller, D W; Yang, Y

    2010-01-01

    All particle beam scanning systems are subject to dose delivery errors due to errors in position, energy and intensity of the delivered beam. In addition, finite scan speeds, beam spill non-uniformities, and delays in detector, detector electronics and magnet responses will all contribute errors in delivery. In this paper, we present dose errors for an 8 x 10 x 8 cm 3 target of uniform water equivalent density with 8 cm spread out Bragg peak and a prescribed dose of 2 Gy. Lower doses are also analyzed and presented later in the paper. Beam energy errors and errors due to limitations of scanning system hardware have been included in the analysis. By using Gaussian shaped pencil beams derived from measurements in the research room of the James M Slater Proton Treatment and Research Center at Loma Linda, CA and executing treatment simulations multiple times, statistical dose errors have been calculated in each 2.5 mm cubic voxel in the target. These errors were calculated by delivering multiple treatments to the same volume and calculating the rms variation in delivered dose at each voxel in the target. The variations in dose were the result of random beam delivery errors such as proton energy, spot position and intensity fluctuations. The results show that with reasonable assumptions of random beam delivery errors, the spot scanning technique yielded an rms dose error in each voxel less than 2% or 3% of the 2 Gy prescribed dose. These calculated errors are within acceptable clinical limits for radiation therapy.

  14. Multigroup and coupled forward-adjoint Monte Carlo calculation efficiencies for secondary neutron doses from proton beams

    International Nuclear Information System (INIS)

    Kelsey IV, Charles T.; Prinja, Anil K.

    2011-01-01

    We evaluate the Monte Carlo calculation efficiency for multigroup transport relative to continuous energy transport using the MCNPX code system to evaluate secondary neutron doses from a proton beam. We consider both fully forward simulation and application of a midway forward adjoint coupling method to the problem. Previously we developed tools for building coupled multigroup proton/neutron cross section libraries and showed consistent results for continuous energy and multigroup proton/neutron transport calculations. We observed that forward multigroup transport could be more efficient than continuous energy. Here we quantify solution efficiency differences for a secondary radiation dose problem characteristic of proton beam therapy problems. We begin by comparing figures of merit for forward multigroup and continuous energy MCNPX transport and find that multigroup is 30 times more efficient. Next we evaluate efficiency gains for coupling out-of-beam adjoint solutions with forward in-beam solutions. We use a variation of a midway forward-adjoint coupling method developed by others for neutral particle transport. Our implementation makes use of the surface source feature in MCNPX and we use spherical harmonic expansions for coupling in angle rather than solid angle binning. The adjoint out-of-beam transport for organs of concern in a phantom or patient can be coupled with numerous forward, continuous energy or multigroup, in-beam perturbations of a therapy beam line configuration. Out-of-beam dose solutions are provided without repeating out-of-beam transport. (author)

  15. Positive correlation between occlusion rate and nidus size of proton beam treated brain arteriovenous malformations (AVMs)

    DEFF Research Database (Denmark)

    Blomquist, Erik; Ronne Engström, Elisabeth; Borota, Ljubisa

    2016-01-01

    symptoms, clinical course, the size of AVM nidus and rate of occlusion was collected. Outcome parameters were the occlusion of the AVM, clinical outcome and side effects.Results. The rate of total occlusion was overall 68%. For target volume 0-2cm3 it was 77%, for 3-10 cm3 80%, for 11-15 cm3 50% and for 16...... of these had no effect and the other only partial occlusion from proton beams. Two thirds of those presenting with seizures reported an improved seizure situation after treatment.Conclusion. Our observations agree with earlier results and show that proton beam irradiation is a treatment alternative for brain......Background. Proton beam radiotherapy of arteriovenous malformations (AVM) in the brain has been performed in Uppsala since 1991. An earlier study based on the first 26 patients concluded that proton beam can be used for treating large and medium sized AVMs that were considered difficult to treat...

  16. SU-E-T-455: Characterization of 3D Printed Materials for Proton Beam Therapy

    International Nuclear Information System (INIS)

    Zou, W; Siderits, R; McKenna, M; Khan, A; Yue, N; McDonough, J; Yin, L; Teo, B; Fisher, T

    2014-01-01

    Purpose: The widespread availability of low cost 3D printing technologies provides an alternative fabrication method for customized proton range modifying accessories such as compensators and boluses. However the material properties of the printed object are dependent on the printing technology used. In order to facilitate the application of 3D printing in proton therapy, this study investigated the stopping power of several printed materials using both proton pencil beam measurements and Monte Carlo simulations. Methods: Five 3–4 cm cubes fabricated using three 3D printing technologies (selective laser sintering, fused-deposition modeling and stereolithography) from five printers were investigated. The cubes were scanned on a CT scanner and the depth dose curves for a mono-energetic pencil beam passing through the material were measured using a large parallel plate ion chamber in a water tank. Each cube was measured from two directions (perpendicular and parallel to printing plane) to evaluate the effects of the anisotropic material layout. The results were compared with GEANT4 Monte Carlo simulation using the manufacturer specified material density and chemical composition data. Results: Compared with water, the differences from the range pull back by the printed blocks varied and corresponded well with the material CT Hounsfield unit. The measurement results were in agreement with Monte Carlo simulation. However, depending on the technology, inhomogeneity existed in the printed cubes evidenced from CT images. The effect of such inhomogeneity on the proton beam is to be investigated. Conclusion: Printed blocks by three different 3D printing technologies were characterized for proton beam with measurements and Monte Carlo simulation. The effects of the printing technologies in proton range and stopping power were studied. The derived results can be applied when specific devices are used in proton radiotherapy

  17. Fabrication of micro-prominences on PTFE surface using proton beam writing

    Energy Technology Data Exchange (ETDEWEB)

    Kitamura, Akane, E-mail: ogawa.akane@jaea.go.jp [Department of Advanced Radiation Technology, Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency, 1233 Watanuki-Machi, Takasaki, Gunma 370-1292 (Japan); Satoh, Takahiro; Koka, Masashi [Department of Advanced Radiation Technology, Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency, 1233 Watanuki-Machi, Takasaki, Gunma 370-1292 (Japan); Kobayashi, Tomohiro [Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 350-0198 (Japan); Kamiya, Tomihiro [Department of Advanced Radiation Technology, Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency, 1233 Watanuki-Machi, Takasaki, Gunma 370-1292 (Japan)

    2013-07-01

    Polytetrafluoroethylene (PTFE) is a typical fluoropolymer and it has several desirable technological properties such as electrical insulation, solid lubrication etc. However, the conventional microstructuring methods have not been well applied to PTFE due to its chemical inertness. Some effective micromachining using synchrotron radiation or ion beam irradiation has been reported. In this study, we create micro-prominences by raising the original surface using proton beam writing (PBW) without chemical etching. A conical prominence was formed by spiral drawing from the center with a 3 MeV proton beam. The body was porous, and the bulk PTFE below the prominence changed to fragmented structures. With decreasing writing speed, the prominence became taller but the height peaked. The prominence gradually reduced in size after the speed reached the optimum value. We expect that these porous projections with high aspect ratio will be versatile in medical fields and microelectromechanical systems (MEMS) technology.

  18. SU-E-J-72: Geant4 Simulations of Spot-Scanned Proton Beam Treatment Plans

    Energy Technology Data Exchange (ETDEWEB)

    Kanehira, T; Sutherland, K; Matsuura, T; Umegaki, K; Shirato, H [Hokkaido University, Sapporo, Hokkaido (Japan)

    2014-06-01

    Purpose: To evaluate density inhomogeneities which can effect dose distributions for real-time image gated spot-scanning proton therapy (RGPT), a dose calculation system, using treatment planning system VQA (Hitachi Ltd., Tokyo) spot position data, was developed based on Geant4. Methods: A Geant4 application was developed to simulate spot-scanned proton beams at Hokkaido University Hospital. A CT scan (0.98 × 0.98 × 1.25 mm) was performed for prostate cancer treatment with three or four inserted gold markers (diameter 1.5 mm, volume 1.77 mm3) in or near the target tumor. The CT data was read into VQA. A spot scanning plan was generated and exported to text files, specifying the beam energy and position of each spot. The text files were converted and read into our Geant4-based software. The spot position was converted into steering magnet field strength (in Tesla) for our beam nozzle. Individual protons were tracked from the vacuum chamber, through the helium chamber, steering magnets, dose monitors, etc., in a straight, horizontal line. The patient CT data was converted into materials with variable density and placed in a parametrized volume at the isocenter. Gold fiducial markers were represented in the CT data by two adjacent voxels (volume 2.38 mm3). 600,000 proton histories were tracked for each target spot. As one beam contained about 1,000 spots, approximately 600 million histories were recorded for each beam on a blade server. Two plans were considered: two beam horizontal opposed (90 and 270 degree) and three beam (0, 90 and 270 degree). Results: We are able to convert spot scanning plans from VQA and simulate them with our Geant4-based code. Our system can be used to evaluate the effect of dose reduction caused by gold markers used for RGPT. Conclusion: Our Geant4 application is able to calculate dose distributions for spot scanned proton therapy.

  19. High-quality electron beam generation in a proton-driven hollow plasma wakefield accelerator

    Science.gov (United States)

    Li, Y.; Xia, G.; Lotov, K. V.; Sosedkin, A. P.; Hanahoe, K.; Mete-Apsimon, O.

    2017-10-01

    Simulations of proton-driven plasma wakefield accelerators have demonstrated substantially higher accelerating gradients compared to conventional accelerators and the viability of accelerating electrons to the energy frontier in a single plasma stage. However, due to the strong intrinsic transverse fields varying both radially and in time, the witness beam quality is still far from suitable for practical application in future colliders. Here we demonstrate the efficient acceleration of electrons in proton-driven wakefields in a hollow plasma channel. In this regime, the witness bunch is positioned in the region with a strong accelerating field, free from plasma electrons and ions. We show that the electron beam carrying the charge of about 10% of 1 TeV proton driver charge can be accelerated to 0.6 TeV with a preserved normalized emittance in a single channel of 700 m. This high-quality and high-charge beam may pave the way for the development of future plasma-based energy frontier colliders.

  20. Characteristic of EBT-XD and EBT3 radiochromic film dosimetry for photon and proton beams

    Science.gov (United States)

    Khachonkham, Suphalak; Dreindl, Ralf; Heilemann, Gerd; Lechner, Wolfgang; Fuchs, Hermann; Palmans, Hugo; Georg, Dietmar; Kuess, Peter

    2018-03-01

    Recently, a new type of radiochromic film, the EBT-XD film, has been introduced for high dose radiotherapy. The EBT-XD film contains the same structure as the EBT3 film but has a slightly different composition and a thinner active layer. This study benchmarks the EBT-XD against EBT3 film for 6 MV and 10 MV photon beams, as well as for 97.4 MeV and 148.2 MeV proton beams and 15-100 kV x-rays. Dosimetric and film reading characteristics, such as post irradiation darkening, film orientation effect, lateral response artifact (LRA), film sensitivity, energy and beam quality dependency were investigated. Furthermore, quenching effects in the Bragg peak were investigated for a single proton beam energy for both film types, in addition measurements were performed in a spread-out Bragg peak. EBT-XD films showed the same characteristic on film darkening as EBT3. The effects between portrait and landscape orientation were reduced by 3.1% (in pixel value) for EBT-XD compared to EBT3 at a dose of 2000 cGy. The LRA is reduced for EBT-XD films for all investigated dose ranges. The sensitivity of EBT-XD films is superior to EBT3 for doses higher than 500 cGy. In addition, EBT-XD showed a similar dosimetric response for photon and proton irradiation with low energy and beam quality dependency. A quenching effect of 10% was found for both film types. The slight decrease in the thickness of the active layer and different composition configuration of EBT-XD resulted in a reduced film orientation effect and LRA, as well as a sensitivity increase in high-dose regions for both photon and proton beams. Overall, the EBT-XD film improved regarding film reading characteristics and showed advantages in the high-dose region for photon and proton beams.

  1. Characteristic of EBT-XD and EBT3 radiochromic film dosimetry for photon and proton beams.

    Science.gov (United States)

    Khachonkham, Suphalak; Dreindl, Ralf; Heilemann, Gerd; Lechner, Wolfgang; Fuchs, Hermann; Palmans, Hugo; Georg, Dietmar; Kuess, Peter

    2018-03-15

    Recently, a new type of radiochromic film, the EBT-XD film, has been introduced for high dose radiotherapy. The EBT-XD film contains the same structure as the EBT3 film but has a slightly different composition and a thinner active layer. This study benchmarks the EBT-XD against EBT3 film for 6 MV and 10 MV photon beams, as well as for 97.4 MeV and 148.2 MeV proton beams and 15-100 kV x-rays. Dosimetric and film reading characteristics, such as post irradiation darkening, film orientation effect, lateral response artifact (LRA), film sensitivity, energy and beam quality dependency were investigated. Furthermore, quenching effects in the Bragg peak were investigated for a single proton beam energy for both film types, in addition measurements were performed in a spread-out Bragg peak. EBT-XD films showed the same characteristic on film darkening as EBT3. The effects between portrait and landscape orientation were reduced by 3.1% (in pixel value) for EBT-XD compared to EBT3 at a dose of 2000 cGy. The LRA is reduced for EBT-XD films for all investigated dose ranges. The sensitivity of EBT-XD films is superior to EBT3 for doses higher than 500 cGy. In addition, EBT-XD showed a similar dosimetric response for photon and proton irradiation with low energy and beam quality dependency. A quenching effect of 10% was found for both film types. The slight decrease in the thickness of the active layer and different composition configuration of EBT-XD resulted in a reduced film orientation effect and LRA, as well as a sensitivity increase in high-dose regions for both photon and proton beams. Overall, the EBT-XD film improved regarding film reading characteristics and showed advantages in the high-dose region for photon and proton beams.

  2. Development of hollow electron beams for proton and ion collimation

    CERN Document Server

    Stancari, G; Kuznetsov, G; Shiltsev, V; Still, D A; Valishev, A; Vorobiev, L G; Assmann, R; Kabantsev, A

    2012-01-01

    Magnetically confined hollow electron beams for controlled halo removal in high-energy colliders such as the Tevatron or the LHC may extend traditional collimation systems beyond the intensity limits imposed by tolerable material damage. They may also improve collimation performance by suppressing loss spikes due to beam jitter and by increasing capture efficiency. A hollow electron gun was designed and built. Its performance and stability were measured at the Fermilab test stand. The gun will be installed in one of the existing Tevatron electron lenses for preliminary tests of the hollow-beam collimator concept, addressing critical issues such as alignment and instabilities of the overlapping proton and electron beams.

  3. Development of hollow electron beams for proton and ion collimation

    CERN Document Server

    Stancari, G.; Kuznetsov, G.; Shiltsev, V.; Still, D.A.; Valishev, A.; Vorobiev, L.G.; Assmann, R.; Kabantsev, A.

    2010-01-01

    Magnetically confined hollow electron beams for controlled halo removal in high-energy colliders such as the Tevatron or the LHC may extend traditional collimation systems beyond the intensity limits imposed by tolerable material damage. They may also improve collimation performance by suppressing loss spikes due to beam jitter and by increasing capture efficiency. A hollow electron gun was designed and built. Its performance and stability were measured at the Fermilab test stand. The gun will be installed in one of the existing Tevatron electron lenses for preliminary tests of the hollow-beam collimator concept, addressing critical issues such as alignment and instabilities of the overlapping proton and electron beams

  4. PIXE analysis using external proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Potocek, V; Potockova, J; Dzmuran, R; Sikora, J

    1985-03-01

    The possibilities were studied of the practical use of the analytical PIXE method. Calibration samples were analyzed of Cu, Cd, Hg and Pb in concentrations of 50 to 500 ..mu..g/l as well as natural samples of drinking water, pond water, human blood plasma, dry waste from ground vegetation, mushrooms, pine needles, aerosols, human hair, leaves and flowers, etc. The samples were processed using precipitation, mineralization or incineration and were trapped on a membrane filter (Synpor) or on a Tatrafan ON 15 foil. Some samples were freeze-dried and compressed into pellets. A proton beam with an intensity of 10 to 70 nA was used for analysis and the proton energy was selected 2.2 MeV. For most targets an exposure of 120 s was preset and the measurement lasted at least 60 s and 600 s at the most. It was found that Synpor filters browned and became more brittle during longer exposures. The other targets did not change during analysis.

  5. Numerical investigation on complex target geometries in the context of laser-accelerated proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Deppert, O.; Harres, K.; Busold, S.; Schaumann, G.; Roth, M. [IKP, Technische Universitaet Darmstadt (Germany); Brabetz, C. [IAP, Goethe Universitaet Frankfurt (Germany); Schollmeier, M.; Geissel, M. [Sandia National Laboratories, NM (United States); Bagnoud, V. [GSI - Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Neely, D. [Rutherford Appleton Laboratory (United Kingdom); McKenna, P. [University of Strathclyde (United Kingdom)

    2012-07-01

    The irradiation of thin metal foils by an ultra-intense laser pulse leads to the generation of a highly laminar, intense proton beam accelerated from the target rear side by a mechanism called TNSA. This acceleration mechanism strongly depends on the geometry of the target. The acceleration originates from the formation of a Gaussian-like electron sheath leading to an electric field in the order of TV/m. This sheath field-ionizes the target rear side and is able to accelerate protons from a hydrogen contamination layer. The Gaussian-like sheath adds an energy dependent divergence to the spatial proton beam profile. For future applications it is essential to reduce the divergence already from the source of the acceleration process. Therefore different target geometries were studied numerically with the help of Particle-In-Cell (PIC) simulations. Both, the influence of the target geometry as well as the influence of the laser beam profile onto the proton trajectories are discussed. Furthermore, the first experimental results of a dedicated target geometry for laser-ion acceleration are presented.

  6. GPU-based fast pencil beam algorithm for proton therapy

    International Nuclear Information System (INIS)

    Fujimoto, Rintaro; Nagamine, Yoshihiko; Kurihara, Tsuneya

    2011-01-01

    Performance of a treatment planning system is an essential factor in making sophisticated plans. The dose calculation is a major time-consuming process in planning operations. The standard algorithm for proton dose calculations is the pencil beam algorithm which produces relatively accurate results, but is time consuming. In order to shorten the computational time, we have developed a GPU (graphics processing unit)-based pencil beam algorithm. We have implemented this algorithm and calculated dose distributions in the case of a water phantom. The results were compared to those obtained by a traditional method with respect to the computational time and discrepancy between the two methods. The new algorithm shows 5-20 times faster performance using the NVIDIA GeForce GTX 480 card in comparison with the Intel Core-i7 920 processor. The maximum discrepancy of the dose distribution is within 0.2%. Our results show that GPUs are effective for proton dose calculations.

  7. On some methods to produce high-energy polarized electron beams by means of proton synchrotrons

    International Nuclear Information System (INIS)

    Bessonov, E.G.; Vazdik, Ya.A.

    1980-01-01

    Some methods of production of high-energy polarized electron beams by means of proton synchrotrons are considered. These methods are based on transfer by protons of a part of their energy to the polarized electrons of a thin target placed inside the working volume of the synchrotron. It is suggested to use as a polarized electron target a magnetized crystalline iron in which proton channeling is realized, polarized atomic beams and the polarized plasma. It is shown that by this method one can produce polarized electron beams with energy approximately 100 GeV, energy spread +- 5 % and intensity approximately 10 7 electron/c, polarization approximately 30% and with intensity approximately 10 4 -10 5 electron/c, polarization approximately 100% [ru

  8. Effects of High-Energy Proton-Beam Irradiation on the Magnetic Properties of ZnO Nanorods

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jun Kue; Kwon, Hyeok-Jung; Cho, Yong Sub [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    There are still many problem for the application due to its unstable magnetism state and too small magnetization values. Here we investigate magnetic properties of ZnO nanorods after high-energy proton-beam irradiation. Electron spin resonance (ESR) measurement on temperature was made to identify intrinsic or extrinsic defects as well as to observe magnetic ordering after irradiation. Understanding the effects of proton beam irradiation on magnetic behavior may help to shed light on the mechanism responsible for the magnetic ordering in this material. We have investigated proton-beam irradiation effects on the magnetic properties of ZnO nanorods. After irradiation a broad ESR line is observed, indicating emergence of ferromagnetic ordering up to room temperature. In M-H curve, stronger coercive field is observed after irradiation.

  9. Development of the heat sink structure of a beam dump for the proton accelerator

    International Nuclear Information System (INIS)

    Maeng, W. Y.; Gil, C. S.; Kim, J. H.; Kim, D. H.

    2007-01-01

    The beam dump is the essential component for the good beam quality and the reliable performance of the proton accelerator. The beam dump for a 20 MeV and 20 mA proton accelerator was designed and manufactured in this study. The high heats deposited, and the large amount of radioactivity produced in beam dump should be reduced by the proper heat sink structure. The heat source by the proton beam of 20 MeV and 20 mA was calculated. The radioactivity assessments of the beam dump were carried out for the economic shielding design with safety. The radioactivity by the protons and secondary neutrons in designed beam dump were calculated in this sturdy. The effective engineering design for the beam dump cooling was performed, considering the mitigation methods of the deposited heats with small angle, the power densities with the stopping ranges in the materials and the heat distributions in the beam dump. The heat sink structure of the beam dump was designed to meet the accelerator characteristics by placing two plates of 30 cm by 60 cm at an angle of 12 degree. The highest temperatures of the graphite, copper, and copper faced by cooling water were designed to be 223 degree, 146 degree, and 85 degree, respectively when the velocity of cooling water was 3 m/s. The heat sink structure was manufactured by the brazing graphite tiles to a copper plate with the filler alloy of Ti-Cu-Ag. The brazing procedure was developed. The tensile stress of the graphite was less than 75% of a maximum tensile stress during the accelerator operation based on the analysis. The safety analyses for the commissioning of the accelerator operation were also performed. The specimens from the brazed parts of beam dump structure were made to identify manufacturing problems. The soundness of the heat sink structure of the beam dump was confirmed by the fatigue tests of the brazed specimens of the graphite-copper tile components with the repetitive heating and cooling. The heat sink structure developed

  10. Prototype system for proton beam range measurement based on gamma electron vertex imaging

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Han Rim [Neutron Utilization Technology Division, Korea Atomic Energy Research Institute, 111, Daedeok-daero 989beon-gil, Yuseong-gu, Daejeon 34057 (Korea, Republic of); Kim, Sung Hun; Park, Jong Hoon [Department of Nuclear Engineering, Hanyang University, Seongdong-gu, Seoul 04763 (Korea, Republic of); Jung, Won Gyun [Heavy-ion Clinical Research Division, Korean Institute of Radiological & Medical Sciences, Seoul 01812 (Korea, Republic of); Lim, Hansang [Department of Electronics Convergence Engineering, Kwangwoon University, Seoul 01897 (Korea, Republic of); Kim, Chan Hyeong, E-mail: chkim@hanyang.ac.kr [Department of Nuclear Engineering, Hanyang University, Seongdong-gu, Seoul 04763 (Korea, Republic of)

    2017-06-11

    In proton therapy, for both therapeutic effectiveness and patient safety, it is very important to accurately measure the proton dose distribution, especially the range of the proton beam. For this purpose, recently we proposed a new imaging method named gamma electron vertex imaging (GEVI), in which the prompt gammas emitting from the nuclear reactions of the proton beam in the patient are converted to electrons, and then the converted electrons are tracked to determine the vertices of the prompt gammas, thereby producing a 2D image of the vertices. In the present study, we developed a prototype GEVI system, including dedicated signal processing and data acquisition systems, which consists of a beryllium plate (= electron converter) to convert the prompt gammas to electrons, two double-sided silicon strip detectors (= hodoscopes) to determine the trajectories of those converted electrons, and a plastic scintillation detector (= calorimeter) to measure their kinetic energies. The system uses triple coincidence logic and multiple energy windows to select only the events from prompt gammas. The detectors of the prototype GEVI system were evaluated for electronic noise level, energy resolution, and time resolution. Finally, the imaging capability of the GEVI system was tested by imaging a {sup 90}Sr beta source, a {sup 60}Co gamma source, and a 45-MeV proton beam in a PMMA phantom. The overall results of the present study generally show that the prototype GEVI system can image the vertices of the prompt gammas produced by the proton nuclear interactions.

  11. WE-E-BRB-00: Motion Management for Pencil Beam Scanning Proton Therapy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-06-15

    Strategies for treating thoracic and liver tumors using pencil beam scanning proton therapy Thoracic and liver tumors have not been treated with pencil beam scanning (PBS) proton therapy until recently. This is because of concerns about the significant interplay effects between proton spot scanning and patient’s respiratory motion. However, not all tumors have unacceptable magnitude of motion for PBS proton therapy. Therefore it is important to analyze the motion and understand the significance of the interplay effect for each patient. The factors that affect interplay effect and its washout include magnitude of motion, spot size, spot scanning sequence and speed. Selection of beam angle, scanning direction, repainting and fractionation can all reduce the interplay effect. An overview of respiratory motion management in PBS proton therapy including assessment of tumor motion and WET evaluation will be first presented. As thoracic tumors have very different motion patterns from liver tumors, examples would be provided for both anatomic sites. As thoracic tumors are typically located within highly heterogeneous environments, dose calculation accuracy is a concern for both treatment target and surrounding organs such as spinal cord or esophagus. Strategies for mitigating the interplay effect in PBS will be presented and the pros and cons of various motion mitigation strategies will be discussed. Learning Objectives: Motion analysis for individual patients with respect to interplay effect Interplay effect and mitigation strategies for treating thoracic/liver tumors with PBS Treatment planning margins for PBS The impact of proton dose calculation engines over heterogeneous treatment target and surrounding organs I have a current research funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian; L. Lin, I have a current funding from Varian Medical System under the master agreement between University of Pennsylvania and

  12. WE-E-BRB-00: Motion Management for Pencil Beam Scanning Proton Therapy

    International Nuclear Information System (INIS)

    2016-01-01

    Strategies for treating thoracic and liver tumors using pencil beam scanning proton therapy Thoracic and liver tumors have not been treated with pencil beam scanning (PBS) proton therapy until recently. This is because of concerns about the significant interplay effects between proton spot scanning and patient’s respiratory motion. However, not all tumors have unacceptable magnitude of motion for PBS proton therapy. Therefore it is important to analyze the motion and understand the significance of the interplay effect for each patient. The factors that affect interplay effect and its washout include magnitude of motion, spot size, spot scanning sequence and speed. Selection of beam angle, scanning direction, repainting and fractionation can all reduce the interplay effect. An overview of respiratory motion management in PBS proton therapy including assessment of tumor motion and WET evaluation will be first presented. As thoracic tumors have very different motion patterns from liver tumors, examples would be provided for both anatomic sites. As thoracic tumors are typically located within highly heterogeneous environments, dose calculation accuracy is a concern for both treatment target and surrounding organs such as spinal cord or esophagus. Strategies for mitigating the interplay effect in PBS will be presented and the pros and cons of various motion mitigation strategies will be discussed. Learning Objectives: Motion analysis for individual patients with respect to interplay effect Interplay effect and mitigation strategies for treating thoracic/liver tumors with PBS Treatment planning margins for PBS The impact of proton dose calculation engines over heterogeneous treatment target and surrounding organs I have a current research funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian; L. Lin, I have a current funding from Varian Medical System under the master agreement between University of Pennsylvania and

  13. Coherent instabilities of proton beams in accelerators and storage rings - experimental results, diagnosis and cures

    International Nuclear Information System (INIS)

    Schnell, W.

    1977-01-01

    The author discusses diagnosis and cure of proton beam instabilities in accelerators and storage rings. Coasting beams and bunched beams are treated separately and both transverse and longitudinal instabilities are considered. (B.D.)

  14. Large Logarithms in the Beam Normal Spin Asymmetry of Elastic Electron--Proton Scattering

    Energy Technology Data Exchange (ETDEWEB)

    Andrei Afanasev; Mykola Merenkov

    2004-06-01

    We study a parity-conserving single-spin beam asymmetry of elastic electron-proton scattering induced by an absorptive part of the two-photon exchange amplitude. It is demonstrated that excitation of inelastic hadronic intermediate states by the consecutive exchange of two photons leads to logarithmic and double-logarithmic enhancement due to contributions of hard collinear quasi-real photons. The asymmetry at small electron scattering angles is expressed in terms of the total photoproduction cross section on the proton, and is predicted to reach the magnitude of 20-30 parts per million. At these conditions and fixed 4-momentum transfers, the asymmetry is rising logarithmically with increasing electron beam energy, following the high-energy diffractive behavior of total photoproduction cross section on the proton.

  15. Cost-effectiveness analysis of cochlear dose reduction by proton beam therapy for medulloblastoma in childhood

    International Nuclear Information System (INIS)

    Hirano, Emi; Kawabuchi, Koichi; Fuji, Hiroshi; Onoe, Tsuyoshi; Kumar, Vinay; Shirato, Hiroki

    2014-01-01

    The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after treatment with proton or X-ray radiotherapy. The risks of hearing loss were calculated on cochlear dose for each treatment. Three types of health-related quality of life (HRQOL) of EQ-5D, HUI3 and SF-6D were used for estimation of quality-adjusted life years (QALYs). The incremental cost-effectiveness ratio (ICER) for proton beam therapy compared with X-ray radiotherapy was calculated for each HRQOL. Sensitivity analyses were performed to model uncertainty in these parameters. The ICER for EQ-5D, HUI3 and SF-6D were $21 716/QALY, $11 773/QALY, and $20 150/QALY, respectively. One-way sensitivity analyses found that the results were sensitive to discount rate, the risk of hearing loss after proton therapy, and costs of proton irradiation. Cost-effectiveness acceptability curve analysis revealed a 99% probability of proton therapy being cost effective at a societal willingness-to-pay value. Proton beam therapy with cochlear dose reduction improves health outcomes at a cost that is within the acceptable cost-effectiveness range from the payer's standpoint. (author)

  16. Adjuvant Ab Interno Tumor Treatment After Proton Beam Irradiation.

    Science.gov (United States)

    Seibel, Ira; Riechardt, Aline I; Heufelder, Jens; Cordini, Dino; Joussen, Antonia M

    2017-06-01

    This study was performed to show long-term outcomes concerning globe preservation in uveal melanoma patients after proton beam therapy with the main focus on outcomes according to different adjuvant ab interno surgical procedures. Retrospective cohort study. All patients treated with primary proton beam therapy for choroidal or ciliary body melanoma between June 1998 and June 2015 were included. A total of 2499 patients underwent primary proton beam therapy, with local tumor control and globe preservation rates of 95.9% and 94.8% after 5 years, respectively. A total of 110 (4.4%) patients required secondary enucleation. Unresponsive neovascular glaucoma was the leading cause of secondary enucleation in 78 of the 2499 patients (3.1%). The 5-year enucleation-free survival rate was 94.8% in the endoresection group, 94.3% in the endodrainage group, and 93.5% in the comparator group. The log-rank test showed P = .014 (comparator group vs endoresection group) and P = .06 (comparator group vs endodrainage-vitrectomy group). Patients treated with endoresection or endodrainage-vitrectomy developed less radiation retinopathy (30.5% and 37.4% after 5 years, P = .001 and P = .048 [Kaplan-Meier], respectively) and less neovascular glaucoma (11.6% and 21.3% after 5 years, P = .001 and P = .01 [Kaplan-Meier], respectively) compared with the comparator group (52.3% radiation retinopathy and 57.8% neovascular glaucoma after 5 years). This study suggests that in larger tumors the enucleation and neovascular glaucoma rates might be reduced by adjuvant surgical procedures. Although endoresection is the most promising adjuvant treatment option, the endodrainage-vitrectomy is recommended in patients who are ineligible for endoresection. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Variations in the Processing of DNA Double-Strand Breaks Along 60-MeV Therapeutic Proton Beams

    Energy Technology Data Exchange (ETDEWEB)

    Chaudhary, Pankaj; Marshall, Thomas I. [Centre for Cancer Research and Cell Biology, Queen' s University Belfast, Belfast (United Kingdom); Currell, Frederick J. [Centre for Cancer Research and Cell Biology, Queen' s University Belfast, Belfast (United Kingdom); Centre for Plasma Physics, School of Mathematics and Physics, Queen' s University Belfast, Belfast (United Kingdom); Kacperek, Andrzej [Douglas Cyclotron, Clatterbridge Cancer Centre, Bebbington, Wirral (United Kingdom); Schettino, Giuseppe, E-mail: giuseppe.schettino@npl.co.uk [National Physical Laboratory, Teddington (United Kingdom); Prise, Kevin M. [Centre for Cancer Research and Cell Biology, Queen' s University Belfast, Belfast (United Kingdom)

    2016-05-01

    Purpose: To investigate the variations in induction and repair of DNA damage along the proton path, after a previous report on the increasing biological effectiveness along clinically modulated 60-MeV proton beams. Methods and Materials: Human skin fibroblast (AG01522) cells were irradiated along a monoenergetic and a modulated spread-out Bragg peak (SOBP) proton beam used for treating ocular melanoma at the Douglas Cyclotron, Clatterbridge Centre for Oncology, Wirral, Liverpool, United Kingdom. The DNA damage response was studied using the 53BP1 foci formation assay. The linear energy transfer (LET) dependence was studied by irradiating the cells at depths corresponding to entrance, proximal, middle, and distal positions of SOBP and the entrance and peak position for the pristine beam. Results: A significant amount of persistent foci was observed at the distal end of the SOBP, suggesting complex residual DNA double-strand break damage induction corresponding to the highest LET values achievable by modulated proton beams. Unlike the directly irradiated, medium-sharing bystander cells did not show any significant increase in residual foci. Conclusions: The DNA damage response along the proton beam path was similar to the response of X rays, confirming the low-LET quality of the proton exposure. However, at the distal end of SOBP our data indicate an increased complexity of DNA lesions and slower repair kinetics. A lack of significant induction of 53BP1 foci in the bystander cells suggests a minor role of cell signaling for DNA damage under these conditions.

  18. Beam dynamics study in the C235 cyclotron for proton therapy

    International Nuclear Information System (INIS)

    Karamysheva, G.A.; Kostromin, S.A.

    2008-01-01

    Study of the beam dynamics in the C235 cyclotron dedicated to the proton therapy is presented. Results of the computer simulations of the particle motion in the measured magnetic field are given. Study of the resonance influence on the acceleration process was carried out. The corresponding tolerances on the magnetic field imperfections and transverse beam parameters were defined using these simulations

  19. Dynamic control of laser driven proton beams by exploiting self-generated, ultrashort electromagnetic pulses

    Energy Technology Data Exchange (ETDEWEB)

    Kar, S., E-mail: s.kar@qub.ac.uk; Ahmed, H.; Nersisyan, G.; Hanton, F.; Naughton, K.; Lewis, C. L. S.; Borghesi, M. [Centre for Plasma Physics, School of Mathematics and Physics, Queen' s University Belfast, Belfast BT7 1NN (United Kingdom); Brauckmann, S.; Giesecke, A. L.; Willi, O. [Institut für Laser-und Plasmaphysik, Heinrich-Heine-Universität, Düsseldorf (Germany)

    2016-05-15

    As part of the ultrafast charge dynamics initiated by high intensity laser irradiations of solid targets, high amplitude EM pulses propagate away from the interaction point and are transported along any stalks and wires attached to the target. The propagation of these high amplitude pulses along a thin wire connected to a laser irradiated target was diagnosed via the proton radiography technique, measuring a pulse duration of ∼20 ps and a pulse velocity close to the speed of light. The strong electric field associated with the EM pulse can be exploited for controlling dynamically the proton beams produced from a laser-driven source. Chromatic divergence control of broadband laser driven protons (upto 75% reduction in divergence of >5 MeV protons) was obtained by winding the supporting wire around the proton beam axis to create a helical coil structure. In addition to providing focussing and energy selection, the technique has the potential to post-accelerate the transiting protons by the longitudinal component of the curved electric field lines produced by the helical coil lens.

  20. New technique for levitating solid particles using a proton beam

    International Nuclear Information System (INIS)

    Misconi, N.Y.

    1996-01-01

    A new technique for levitating solid particles inside a vacuum chamber is developed using a proton beam. This new technique differs from the classical laser-levitation technique invented by Ashkin in that it does not heat up light-absorbing levitated particles to vaporization. This unique property of the method will make it possible to levitate real interplanetary dust particles in a vacuum chamber and study their spin-up dynamics in a ground-based laboratory. It is found that a flux of protons from a proton gun of ∼ 10 15 cm -2 sec -1 is needed to levitate a 10-mm particle. Confinement of the levitated particle can be achieved by a Z or θ pinch to create a gravity well, or by making the beam profile doughnut in shape. In levitating real interplanetary particles, two spin-up mechanisms can be investigated using this technique: one is the Paddack Effect and the other is a spin-up mechanism by the interaction of F-coronal dust with CMEs (Coronal Mass Ejections). The real interplanetary particles were collected by Brownie and associates (also known as the Brownie Particles) from the earth's upper atmosphere. (author)

  1. High-energy monoenergetic proton beams from two stage acceleration with a slow laser pulse

    Directory of Open Access Journals (Sweden)

    H. Y. Wang

    2015-02-01

    Full Text Available We present a new regime to generate high-energy quasimonoenergetic proton beams in a “slow-pulse” regime, where the laser group velocity v_{g}proton beams can be generated. It is shown by multidimensional particle-in-cell simulation that quasimonoenergetic proton beams with energy up to hundreds of MeV can be generated at laser intensities of 10^{21}  W/cm^{2}.

  2. Proton beam writing for producing holographic images

    International Nuclear Information System (INIS)

    Ow, Y.S.; Breese, M.B.H.; Bettiol, A.A.

    2009-01-01

    This work reports on the writing of computer generated hologram diffraction patterns using focused 2 MeV proton beam irradiation. These patterns were designed using a ray tracing algorithm and written directly into a thick polymethylmethacrylate layer. When the developed holographic pattern was illuminated with a 650 nm laser it produced a good reconstructed image. This work provides means of forming high-resolution, high aspect ratio holographic images in polymers for applications in data storage using switchable holography.

  3. FEASIBILITY OF POSITRON EMISSION TOMOGRAPHY OF DOSE DISTRIBUTION IN PROTON BEAM CANCER THERAPY

    International Nuclear Information System (INIS)

    BEEBE-WANG, J.J.; DILMANIAN, F.A.; PEGGS, S.G.; SCHLYEER, D.J.; VASKA, P.

    2002-01-01

    Proton therapy is a treatment modality of increasing utility in clinical radiation oncology mostly because its dose distribution conforms more tightly to the target volume than x-ray radiation therapy. One important feature of proton therapy is that it produces a small amount of positron-emitting isotopes along the beam-path through the non-elastic nuclear interaction of protons with target nuclei such as 12 C, 14 N, and 16 O. These radioisotopes, mainly 11 C, 13 N and 15 O, allow imaging the therapy dose distribution using positron emission tomography (PET). The resulting PET images provide a powerful tool for quality assurance of the treatment, especially when treating inhomogeneous organs such as the lungs or the head-and-neck, where the calculation of the dose distribution for treatment planning is more difficult. This paper uses Monte Carlo simulations to predict the yield of positron emitters produced by a 250 MeV proton beam, and to simulate the productions of the image in a clinical PET scanner

  4. Impact of the 7 TeV/c Large Hadron Collider proton beam on a copper target

    CERN Document Server

    Tahir, N A; Goddard, B; Hoffmann, Dieter H H; Kain, V; Lomonosov, I V; Piriz, A R; Schmidt, R; Shutov, A; Temporal, M

    2005-01-01

    The Large Hadron Collider (LHC) will allow for collision between two 7 TeV/c proton beams, each comprising 2808 bunches with 1.1*10/sup 11 / protons per bunch, traveling in opposite direction. The bunch length is 0.5 ns and two neighboring bunches are separated by 25 ns so that the duration of the entire beam is about 89 mu s. The beam power profile in the transverse direction is a Gaussian with a standard deviation of 0.2 mm. The energy stored in each beam is about 350 MJ that is sufficient to melt 500 kg of copper. In case of a failure in the machine protection systems, the entire beam could impact directly onto an accelerator equipment. A first estimate of the scale of damage resulting from such a failure has been assessed for a solid copper target hit by the beam by carrying out three- dimensional energy deposition calculations and two-dimensional numerical simulations of the hydrodynamic and thermodynamic response of the target. This work has shown that the penetration depth of the LHC protons will be be...

  5. Investigating proton emitters at the limits of stability with radioactive beams from the Oak Ridge facility

    Energy Technology Data Exchange (ETDEWEB)

    Toth, K.S. [Oak Ridge National Lab., TN (United States); Batchelder, J.C.; Zganjar, E.F. [Louisiana State Univ., Baton Rouge, LA (United States); Bingham, C.R.; Wauters, J. [Tennessee Univ., Knoxville, TN (United States); Davinson, T.; MacKenzie, J.A.; Woods, P.J. [Edinburgh Univ. (United Kingdom)

    1996-10-01

    By using beams from the Holifield Radioactive Ion Beam Facility at ORNL, it should be possible to identify many new ground-state proton emitters in the mass region from Sn to Pb. In these investigations nuclei produced in fusion-evaporation reactions will be separated from incident ions and dispersed in mass/charge with a recoil mass separator and then implanted into a double-sided Si strip detector for study of proton (and {alpha}-particle) radioactivity. This paper summarizes data presently extant on proton emitters and then focuses on tests and initial experiments that will be carried out with stable beams and with radioactive ions as they are developed at the Oak Ridge facility.

  6. Carbon filament beam profile monitor for high energy proton-antiproton storage rings

    International Nuclear Information System (INIS)

    Evans, L.R.; Shafer, R.E.

    1979-01-01

    The measurement of the evolution of the transverse profile of the stored beams in high energy proton storage rings such as the p-anti p colliders at CERN and at FNAL is of considerable importance. In the present note, a simple monitor is discussed which will allow almost non-destructive measurement of the profile of each individual proton and antiproton bunch separately. It is based on the flying wire technique first used at CEA and more recently at the CPS. A fine carbon filament is passed quickly through the beam, acting as a target for secondary particle production. The flux of secondary particles is measured by two scintillator telescopes, one for protons and one for antiprotons, having an angular acceptance between 30 and 100 mrad. Measurements of secondary particle production performed at FNAL in this angular range show that a very respectable flux can be expected

  7. Randomized Clinical Trial Comparing Proton Beam Radiation Therapy with Transarterial Chemoembolization for Hepatocellular Carcinoma: Results of an Interim Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Bush, David A., E-mail: dbush@llu.edu [Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California (United States); Smith, Jason C. [Department of Diagnostic Radiology, Loma Linda University Medical Center, Loma Linda, California (United States); Slater, Jerry D. [Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California (United States); Volk, Michael L. [Transplantation Institute and Liver Center, Loma Linda University Medical Center, Loma Linda, California (United States); Reeves, Mark E. [VA Loma Linda Health Care System, Loma Linda, California (United States); Cheng, Jason [Transplantation Institute and Liver Center, Loma Linda University Medical Center, Loma Linda, California (United States); Grove, Roger [Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California (United States); Vera, Michael E. de [Transplantation Institute and Liver Center, Loma Linda University Medical Center, Loma Linda, California (United States)

    2016-05-01

    Purpose: To describe results of a planned interim analysis of a prospective, randomized clinical trial developed to compare treatment outcomes among patients with newly diagnosed hepatocellular carcinoma (HCC). Methods and Materials: Eligible subjects had either clinical or pathologic diagnosis of HCC and met either Milan or San Francisco transplant criteria. Patients were randomly assigned to transarterial chemoembolization (TACE) or to proton beam radiation therapy. Patients randomized to TACE received at least 1 TACE with additional TACE for persistent disease. Proton beam radiation therapy was delivered to all areas of gross disease to a total dose of 70.2 Gy in 15 daily fractions over 3 weeks. The primary endpoint was progression-free survival, with secondary endpoints of overall survival, local tumor control, and treatment-related toxicities as represented by posttreatment days of hospitalization. Results: At the time of this analysis 69 subjects were available for analysis. Of these, 36 were randomized to TACE and 33 to proton. Total days of hospitalization within 30 days of TACE/proton was 166 and 24 days, respectively (P<.001). Ten TACE and 12 proton patients underwent liver transplantation after treatment. Viable tumor identified in the explanted livers after TACE/proton averaged 2.4 and 0.9 cm, respectively. Pathologic complete response after TACE/proton was 10%/25% (P=.38). The 2-year overall survival for all patients was 59%, with no difference between treatment groups. Median survival time was 30 months (95% confidence interval 20.7-39.3 months). There was a trend toward improved 2-year local tumor control (88% vs 45%, P=.06) and progression-free survival (48% vs 31%, P=.06) favoring the proton beam treatment group. Conclusions: This interim analysis indicates similar overall survival rates for proton beam radiation therapy and TACE. There is a trend toward improved local tumor control and progression-free survival with proton beam. There are

  8. Dosimetry with the scanned proton beam on the PSI gantry

    International Nuclear Information System (INIS)

    Coray, A.; Pedroni, E.; Boehringer, T.; Lin, S.; Lomax, T.; Goitein, G.

    2002-01-01

    Full text: The irradiation facility at PSI is designed for the treatment of deep seated tumours with a proton beam energy of up to 270 MeV. The spot scanning technique, which uses a proton pencil beam applied to the patient, is performed on a compact isocentric gantry. An optimal three-dimensional conformation of the dose distribution to the target volume can be realized. A fast steering system and a redundant interlock system are in operation. The dose delivery is controlled by a parallel plate transmission chamber, which is calibrated in terms of number of protons per monitor unit. The therapy planning is based on an empirical model, which takes into account attenuation of primary protons and losses outside the primary beam through secondary products. The therapy plan predicts an absolute dose. The calibration of the primary monitor is done using a reference thimble ionization chamber inside a homogeneous geometrical dose volume. The reference system is calibrated in a cobalt field at the national office of metrology in terms of absorbed dose to water. The dosimetry protocol used up to last year was based on the ICRU Report Nr. 59, we have switched to the IAEA Code of Practice starting this beam period. Data on the monitor calibration for various energies and using two different reference systems will be shown. The calibration of the beam monitor using a Faraday Cup in the static pencil beam results in a good agreement with the ionization chamber measurements, with a deviation of less than 1%. Following the daily setup of the machine, an extensive quality control and safety check of the whole system is performed. The daily dosimetry quality assurance program includes: measurement of dose rate and monitor ratios; check of the beam position monitors; measurement of a depth dose curve; dose measurement in a regular dose field. The doses measured daily in a regular scanned field show a standard deviation of about 1 %. Further daily checks results, which illustrate

  9. Fractionated proton beam irradiation of pituitary adenomas

    International Nuclear Information System (INIS)

    Ronson, Brian B.; Schulte, Reinhard W.; Han, Khanh P.; Loredo, Lilia N.; Slater, James M.; Slater, Jerry D.

    2006-01-01

    Purpose: Various radiation techniques and modalities have been used to treat pituitary adenomas. This report details our experience with proton treatment of these tumors. Methods and Materials: Forty-seven patients with pituitary adenomas treated with protons, who had at least 6 months of follow-up, were included in this analysis. Forty-two patients underwent a prior surgical resection; 5 were treated with primary radiation. Approximately half the tumors were functional. The median dose was 54 cobalt-gray equivalent. Results: Tumor stabilization occurred in all 41 patients available for follow-up imaging; 10 patients had no residual tumor, and 3 had greater than 50% reduction in tumor size. Seventeen patients with functional adenomas had normalized or decreased hormone levels; progression occurred in 3 patients. Six patients have died; 2 deaths were attributed to functional progression. Complications included temporal lobe necrosis in 1 patient, new significant visual deficits in 3 patients, and incident hypopituitarism in 11 patients. Conclusion: Fractionated conformal proton-beam irradiation achieved effective radiologic, endocrinological, and symptomatic control of pituitary adenomas. Significant morbidity was uncommon, with the exception of postradiation hypopituitarism, which we attribute in part to concomitant risk factors for hypopituitarism present in our patient population

  10. Crystal Collimation Cleaning Measurements with Proton Beams in LHC

    CERN Document Server

    Rossi, Roberto; Andreassen, Odd Oyvind; Butcher, Mark; Dionisio Barreto, Cristovao Andre; Masi, Alessandro; Mirarchi, Daniele; Montesano, Simone; Lamas Garcia, Inigo; Redaelli, Stefano; Scandale, Walter; Serrano Galvez, Pablo; Rijllart, Adriaan; Valentino, Gianluca; CERN. Geneva. ATS Department

    2016-01-01

    During this MD, performed on July 29th, 2016, bent silicon crystal were tested with proton beams for a possible usage of crystal-assisted collimation. Tests were performed at both injection energy and flat top using horizontal and vertical crystal. Loss maps with crystals at 6.5 TeV were measured.

  11. Implementation of pencil kernel and depth penetration algorithms for treatment planning of proton beams

    International Nuclear Information System (INIS)

    Russell, K.R.; Saxner, M.; Ahnesjoe, A.; Montelius, A.; Grusell, E.; Dahlgren, C.V.

    2000-01-01

    The implementation of two algorithms for calculating dose distributions for radiation therapy treatment planning of intermediate energy proton beams is described. A pencil kernel algorithm and a depth penetration algorithm have been incorporated into a commercial three-dimensional treatment planning system (Helax-TMS, Helax AB, Sweden) to allow conformal planning techniques using irregularly shaped fields, proton range modulation, range modification and dose calculation for non-coplanar beams. The pencil kernel algorithm is developed from the Fermi-Eyges formalism and Moliere multiple-scattering theory with range straggling corrections applied. The depth penetration algorithm is based on the energy loss in the continuous slowing down approximation with simple correction factors applied to the beam penumbra region and has been implemented for fast, interactive treatment planning. Modelling of the effects of air gaps and range modifying device thickness and position are implicit to both algorithms. Measured and calculated dose values are compared for a therapeutic proton beam in both homogeneous and heterogeneous phantoms of varying complexity. Both algorithms model the beam penumbra as a function of depth in a homogeneous phantom with acceptable accuracy. Results show that the pencil kernel algorithm is required for modelling the dose perturbation effects from scattering in heterogeneous media. (author)

  12. Development of abiotic-stress resistant warm season trufgrasses by proton-beam irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Y. W.; Kim, J. Y.; Jeong, S. H. [Korea Univ., Seoul (Korea, Republic of)

    2007-04-15

    The direct use of mutation is a valuable approach to generate genetic variation in crop species by altering agronomically useful major traits. The proton beam, as a mutagen, was applied to improve resistance traits of Zoysia grass under various abiotic stresses. Proton beam was irradiated to mature dry seeds of Zenith (Zoysia grass), which is well-adapted to Korean climate, using a proton- accelerator with seven different doses (50, 100, 150, 200, 250, 300, 400 Gy). Individual seedling of M1 plant was transplanted from the seed bed and allowed to reach appropriate plant mass. Clones that showed superior growth were chosen and transplanted to pots for further clone propagation and field evaluation. Growth characteristics of turfgrass, such as plant height, leaf length, leaf width, number of tiller were evaluated ninety days after sowing. Although large variation within each dose, noticeable differences were found among different irradiated doses. Most of the mutant clones derived from the irradiation treatment showed more vigorous growth than the control plants. RAPD (Random Amplified Polymorphic DNA) and AFLP (Amplified Fragment Length Polymorphism) methods were conducted to analyze genomic variations associated with proton beam irradiation. In order to establish selection criteria for selection of salt-stress resistance plants, an in vitro method that is able to select salt-stress resistant mutants in liquid media without ambient disturbances. Total 647 predominance clones that were considered as abiotic stress resistant mutants were transplanted to the field for further evaluation.

  13. Development of ion/proton beam equipment for industrial uses

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Byung Ho; Lee, J. H.; Cho, Y. S.; Joo, P. K.; Kang, S. S.; Song, W. S.; Kim, H. J.; Chang, G. H.; Bang, S. W

    1999-12-01

    KAERI has possessed design and fabrication technologies of various ion sources including Duoplasmatron and DuoPiGatron developed by R and D projects of the long-term nuclear technology development program. In order to industrialize ion beam equipments utilizing these ion sources, a technology transfer project for a technology transfer project for a domestic firm has been performed. Under this project, engineers of the firm have been trained through classroom lectures of ion beam principles and OJT, an ion/proton beam equipment (DEMO equipment) has been designed, assembled and commissioned jointly with the engineers. Quality of the ion sources has been quantified, and technologies for ion beam equipment construction, functional test and application research have been developed. The DEMO equipment, which consists of an ion source, power supplies, vacuum, cooling and target systems, has been fabricated and tested to secure stability and reliability for industrial uses. Various characteristic tests including high voltage insulation, beam extraction, beam current measuring, etc. have been performed. This DEMO can be utilized for ion sources development as well as ion beam process development for various industrial products. Engineers of the firm have been trained for the industrialization of ion beam equipment and joined in beam application technology development to create industrial needs of beam equipment. (author)

  14. Experimental determination of the complete spin structure for anti-proton + proton -> anti-\\Lambda + \\Lambda at anti-proton beam momentum of 1.637 GeV/c

    CERN Document Server

    Paschke, K.D.; Berdoz, A.; Franklin, G.B.; Khaustov, P.; Meyer, C.A.; Bradtke, C.; Gehring, R.; Goertz, S.; Harmsen, J.; Meier, A.; Meyer, W.; Radtke, E.; Reicherz, G.; Dutz, H.; Pluckthun, M.; Schoch, B.; Dennert, H.; Eyrich, W.; Hauffe, J.; Metzger, A.; Moosburger, M.; Stinzing, F.; Wirth, St.; Fischer, H.; Franz, J.; Heinsius, F.H.; Kriegler, E.; Schmitt, H.; Bunker, B.; Hertzog, D.; Jones, T.; Tayloe, R.; Broders, R.; Geyer, R.; Kilian, K.; Oelert, W.; Rohrich, K.; Sachs, K.; Sefzick, T.; Bassalleck, B.; Eilerts, S.; Fields, D.E.; Kingsberry, P.; Lowe, J.; Stotzer, R.; Johansson, T.; Pomp, S.; Wirth, St.

    2006-01-01

    The reaction anti-proton + proton -> anti-\\Lambda + \\Lambda -> anti-proton + \\pi^+ + proton + \\pi^- has been measured with high statistics at anti-proton beam momentum of 1.637 GeV/c. The use of a transversely-polarized frozen-spin target combined with the self-analyzing property of \\Lambda/anti-\\Lambda decay allows access to unprecedented information on the spin structure of the interaction. The most general spin-scattering matrix can be written in terms of eleven real parameters for each bin of scattering angle, each of these parameters is determined with reasonable precision. From these results all conceivable spin-correlations are determined with inherent self-consistency. Good agreement is found with the few previously existing measurements of spin observables in anti-proton + proton -> anti-\\Lambda + \\Lambda near this energy. Existing theoretical models do not give good predictions for those spin-observables that had not been previously measured.

  15. Polarized proton beam for eRHIC

    Energy Technology Data Exchange (ETDEWEB)

    Huang, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Meot, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ptitsyn, V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Roser, T. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    RHIC has provided polarized proton collisions from 31 GeV to 255 GeV in the past decade. To preserve polarization through numerous depolarizing resonances through the whole accelerator chain, harmonic orbit correction, partial snakes, horizontal tune jump system and full snakes have been used. In addition, close attentions have been paid to betatron tune control, orbit control and beam line alignment. The polarization of 60% at 255 GeV has been delivered to experiments with 1.8×1011 bunch intensity. For the eRHIC era, the beam brightness has to be maintained to reach the desired luminosity. Since we only have one hadron ring in the eRHIC era, existing spin rotator and snakes can be converted to six snake configuration for one hadron ring. With properly arranged six snakes, the polarization can be maintained at 70% at 250 GeV. This paper summarizes the effort and plan to reach high polarization with small emittance for eRHIC.

  16. Proton Drivers for neutrino beams and other high intensity applications

    CERN Document Server

    Garoby, R; Koseki, T; Thomason, J

    2013-01-01

    CERN, Fermilab, J-PARC and RAL tentatively plan to have proton accelerators delivering multi-MW of beam power in view of enhancing their physics reach especially in the domain of neutrinos. These plans are described, together with their benefits for other applications.

  17. Bragg peak proton beam treatment of arteriovenous malformations of the brain

    International Nuclear Information System (INIS)

    Kjellberg, R.N.; Poletti, C.E.; Roberson, G.H.; Adams, R.D.

    1978-01-01

    This report describes 27 patients treated for arteriovenous malformations of the brain by the Bragg Peak proton beam method during the past 12 years. The authors are led to a measure of confidence that Bragg Peak proton therapy can be provided without lethal risk attributed to the procedure. In 21 patients no neurological change has occurred, two patients experienced neurological improvement and four have developed new neurological abnormalities considered complications of the therapy. (Auth.)

  18. Dynamics of intense pulsed proton beam in the Nagaoka ETIGO-I

    International Nuclear Information System (INIS)

    Tanaka, Hajime; Konno, Kohji; Masugata, Katsumi; Yatsui, Kiyoshi; Matsui, Masao

    1982-01-01

    Dynamics of an intense pulsed proton beam have been studied by measuring nuclear reactions as well as by a biased ion-collector (BIC). When the ion-current density (Jsub(i)) is small such that Jsub(i) lt 30 A/cm 2 , the proton numer measured by BIC is in good agreement with that by nuclear activation. Good linearity exists between time integrated gamma -ray signal and proton number measured by the activation. Hence, it would be possible to obtain the proton number quantitatively even when a target ''blow-off'' takes place at Jsub(i) gt 1 kA/cm 2 . Prompt gamma -ray is also measured by the time-of-flight method to yield reasonable agreement with the applied peak potential. (author)

  19. Beam Dynamics Studies for High-Intensity Beams in the CERN Proton Synchrotron

    CERN Document Server

    AUTHOR|(CDS)2082016; Benedikt, Michael

    With the discovery of the Higgs boson, the existence of the last missing piece of the Standard Model of particle physics (SM) was confirmed. However, even though very elegant, this theory is unable to explain, for example, the generation of neutrino masses, nor does it account for dark energy or dark matter. To shed light on some of these open questions, research in fundamental particle physics pursues two complimentary approaches. On the one hand, particle colliders working at the high-energy frontier, such as the Large Hadron Collider (LHC) at the European Organization for Nuclear Research (CERN), located in Geneva, Switzerland, are utilized to investigate the fundamental laws of nature. Alternatively, fixed target facilities require high-intensity beams to create a large flux of secondary particles to investigate, for example, rare particle decay processes, or to create neutrino beams. This thesis investigates limitations arising during the acceleration of high-intensity beams at the CERN Proton Synchrotro...

  20. Basic Research and Feasibility Study of Radioisotope Production using 100 MeV Proton Beam

    International Nuclear Information System (INIS)

    Yoo, K. H.; Yoon, K. S.; Cho, W. J.; Park, S. I.; Han, H. S.; Yang, S. D.; Jeon, K. S.; Kim, J. H.; Yang, T. K.

    2010-04-01

    Results of the project are various nuclei, such as 82 Rb, 68 Ga, 67 Cu, 22 Na and so on, can be produced by irradiating 100 MeV proton beam, by irradiating proton beam to the nat Ga target, the 68 Ge, mother nucleus of positron emitting 68 Ga, is produced based on the nat Ga(p,x) 68 Ge reaction, the target system for the high-energy of proton beam can produce more than 2 species of radioisotope at the same time by employing tandem targets, 68 Ge/ 68 Ga generator, 82 Sr(25.34d)/ 82 Rb generator - 67 Cu production method, 70 Zn electroplating technology based on the electrochemistry, the container, whose weight is about 3 ton, is made by depleted uranium and because of the unstable situation for the supply and demand of reactor produced radioisotope, the need for the cyclotron produced radioisotopes is dramatically increased all over the world.

  1. Resonant beam behavior studies in the Proton Storage Ring

    Directory of Open Access Journals (Sweden)

    S. Cousineau

    2003-07-01

    Full Text Available We present studies of space-charge-induced beam profile broadening at high intensities in the Proton Storage Ring (PSR at Los Alamos National Laboratory. We investigate the profile broadening through detailed particle-in-cell simulations of several experiments and obtain results in good agreement with the measurements. We interpret these results within the framework of coherent resonance theory. With increasing intensity, our simulations show strong evidence for the presence of a quadrupole-mode resonance of the beam envelope with the lattice in the vertical plane. Specifically, we observe incoherent tunes crossing integer values, and large amplitude, nearly periodic envelope oscillations. At the highest operating intensities, we observe a continuing relaxation of the beam through space charge forces leading to emittance growth. The increase of emittance commences when the beam parameters encounter an envelope stop band. Once the stop band is reached, the emittance growth balances the intensity increase to maintain the beam near the stop band edge. Additionally, we investigate the potential benefit of a stop band correction to the high intensity PSR beam.

  2. Radial focusing and energy compression of a laser-produced proton beam by a synchronous rf field

    Directory of Open Access Journals (Sweden)

    Masahiro Ikegami

    2009-06-01

    Full Text Available The dynamics of a MeV laser-produced proton beam affected by a radio frequency (rf electric field has been studied. The proton beam was emitted normal to the rear surface of a thin polyimide target irradiated with an ultrashort pulsed laser with a power density of 4×10^{18}  W/cm^{2}. The energy spread was compressed to less than 11% at the full width at half maximum (FWHM by an rf field. Focusing and defocusing effects of the transverse direction were also observed. These effects were analyzed and reproduced by Monte Carlo simulations. The simulation results show that the transversely focused protons had a broad continuous spectrum, while the peaks in the proton spectrum were defocused. Based on this new information, we propose that elimination of the continuous energy component of laser-produced protons is possible by utilizing a focal length difference between the continuous spectral protons and the protons included in the spectral peak.

  3. Beam tests of prototype fiber detectors for the H1 forward proton spectrometer

    International Nuclear Information System (INIS)

    Baehr, J.; Hiller, K.; Hoffmann, B.; Luedecke, H.; Menchikov, A.; Nahnhauer, R.; Roloff, H.E.; Tonisch, F.; Voelkert, R.

    1994-07-01

    Different prototypes of fiber detectors with an internal trigger system were tested in a 5 GeV electron beam at DESY. A silicon microstrip telescope was used for an external reference measurement of the beam to study the spatial resolution of the fiber detectors. On average 75% of all crossing electron tracks could be reconstructed with a precision better than 150 μm. These successful methodical investigations led to the installation of similar detectors in the proton beamline 81 m downstream of the central H1-detector at HERA as part of a forward proton spectrometer in spring 1994. (orig.)

  4. Beam tests of prototype fiber detectors for the H1 forward proton spectrometer

    International Nuclear Information System (INIS)

    Baehr, J.; Hiller, K.; Hoffmann, B.; Luedecke, H.; Menchikov, A.; Nahnhauer, R.; Roloff, H.E.; Tonisch, F.; Voelkert, R.

    1995-01-01

    Different prototypes of fiber detectors with an internal trigger system were tested in a 5 GeV electron beam at DESY. A silicon microstrip telescope was used for an external reference measurement of the beam to study the spatial resolution of the fiber detectors. On average 75% of all crossing electron tracks could be reconstructed with a precision better than 150 μm. These successful methodical investigations led to the installation of similar detectors in the proton beamline 81 m downstream of the central H1-detector at HERA as part of a forward proton spectrometer in spring 1994. (orig.)

  5. Proton beam therapy in the management of skull base chordomas: systematic review of indications, outcomes, and implications for neurosurgeons.

    Science.gov (United States)

    Matloob, Samir A; Nasir, Haleema A; Choi, David

    2016-08-01

    Chordomas are rare tumours affecting the skull base. There is currently no clear consensus on the post-surgical radiation treatments that should be used after maximal tumour resection. However, high-dose proton beam therapy is an accepted option for post-operative radiotherapy to maximise local control, and in the UK, National Health Service approval for funding abroad is granted for specific patient criteria. To review the indications and efficacy of proton beam therapy in the management of skull base chordomas. The primary outcome measure for review was the efficacy of proton beam therapy in the prevention of local occurrence. A systematic review of English and non-English articles using MEDLINE (1946-present) and EMBASE (1974-present) databases was performed. Additional studies were reviewed when referenced in other studies and not available on these databases. Search terms included chordoma or chordomas. The PRISMA guidelines were followed for reporting our findings as a systematic review. A total of 76 articles met the inclusion and exclusion criteria for this review. Limitations included the lack of documentation of the extent of primary surgery, tumour size, and lack of standardised outcome measures. Level IIb/III evidence suggests proton beam therapy given post operatively for skull base chordomas results in better survival with less damage to surrounding tissue. Proton beam therapy is a grade B/C recommended treatment modality for post-operative radiation therapy to skull base chordomas. In comparison to other treatment modalities long-term local control and survival is probably improved with proton beam therapy. Further, studies are required to directly compare proton beam therapy to other treatment modalities in selected patients.

  6. Physical measurements with a high-energy proton beam using liquid and solid tissue substitutes

    International Nuclear Information System (INIS)

    Constantinou, C.; Kember, N.F.; Huxtable, G.; Whitehead, C.

    1980-01-01

    The measurement of the physical parameters of a high-energy proton beam, using a range of liquid and solid tissue substitutes, is described. The system, the detectors used and the experimental verification of the tissue equivalence of the new tissue substitutes is presented. The measurements with the scattered but uncollimated proton beam in muscle-and brain-equivalent liquids and in water are compared to similar data obtained from the scattered but collimated beam. The effect of lung, fat and bone on the dose distributions in composite phantoms is also investigated and the necessary corrections established. A simulated patient treatment indicated that the Bragg peak can be positioned with an error not exceeding +-0.5 mm. (author)

  7. The rapid secondary electron imaging system of the proton beam writer at CIBA

    International Nuclear Information System (INIS)

    Udalagama, C.N.B.; Bettiol, A.A.; Kan, J.A. van; Teo, E.J.; Watt, F.

    2007-01-01

    The recent years have witnessed a proliferation of research involving proton beam (p-beam) writing. This has prompted investigations into means of optimizing the process of p-beam writing so as to make it less time consuming and more efficient. One such avenue is the improvement of the pre-writing preparatory procedures that involves beam focusing and sample alignment which is centred on acquiring images of a resolution standard or sample. The conventional mode of imaging used up to now has utilized conventional nuclear microprobe signals that are of a pulsed nature and are inherently slow. In this work, we report the new imaging system that has been introduced, which uses proton induced secondary electrons. This in conjunction with software developed in-house that uses a National Instruments DAQ card with hardware triggering, facilitates large data transfer rates enabling rapid imaging. Frame rates as much as 10 frames/s have been achieved at an imaging resolution of 512 x 512 pixels

  8. Biological intercomparison using gut crypt survivals for proton and carbon-ion beams

    International Nuclear Information System (INIS)

    Uzawa, Akiko; Ando, Koichi; Furusawa, Yoshiya

    2007-01-01

    Charged particle therapy depends on biological information for the dose prescription. Relative biological effectiveness or RBE for this requirement could basically be provided by experimental data. As RBE values of protons and carbon ions depend on several factors such as cell/tissue type, biological endpoint, dose and fractionation schedule, a single RBE value could not deal with all different radiosensitivities. However, any biological model with accurate reproducibility is useful for comparing biological effectiveness between different facilities. We used mouse gut crypt survivals as endpoint, and compared the cell killing efficiency of proton beams at three Japanese facilities. Three Linac X-ray machines with 4 and 6 MeV were used as reference beams, and there was only a small variation (coefficient of variance<2%) in biological effectiveness among them. The RBE values of protons relative to Linac X-rays ranged from 1.0 to 1.11 at the middle of a 6-cm SOBP (spread-out Bragg peak) and from 0.96 to 1.01 at the entrance plateau. The coefficient of variance for protons ranged between 4.0 and 5.1%. The biological comparison of carbon ions showed fairly good agreement in that the difference in biological effectiveness between National Institute of Radiological Sciences (NIRS)/ Heavy Ion Medical Accelerator in Chiba (HIMAC) and Gesellschaft fur Schwerionenforschung (GSI)/Heavy Ion Synchrotron (SIS) was 1% for three positions within the 6-cm SOBP. The coefficient of variance was <1.7, <0.6 and <1.6% for proximal, middle and distal SOBP, respectively. We conclude that the inter-institutional variation of biological effectiveness is smaller for carbon ions than protons, and that beam-spreading methods of carbon ions do not critically influence gut crypt survival. (author)

  9. High quality proton beams from hybrid integrated laser-driven ion acceleration systems

    Energy Technology Data Exchange (ETDEWEB)

    Sinigardi, Stefano, E-mail: sinigardi@bo.infn.it [Dipartimento di Fisica e Astronomia, Università di Bologna and INFN Sezione di Bologna, Via Irnerio 46, I-40126 Bologna (Italy); Turchetti, Giorgio; Rossi, Francesco; Londrillo, Pasquale [Dipartimento di Fisica e Astronomia, Università di Bologna and INFN Sezione di Bologna, Via Irnerio 46, I-40126 Bologna (Italy); Giove, Dario; De Martinis, Carlo [Dipartimento di Fisica, Università di Milano and INFN Sezione di Milano, Via F.lli Cervi 201, I-20090 Segrate (Italy); Bolton, Paul R. [Kansai Photon Science Institute (JAEA), Umemidai 8-1-7, Kizugawa-shi, Kyoto 619-0215 (Japan)

    2014-03-11

    We consider a hybrid acceleration scheme for protons where the laser generated beam is selected in energy and angle and injected into a compact linac, which raises the energy from 30 to 60 MeV. The laser acceleration regime is TNSA and the energy spectrum is determined by the cutoff energy and proton temperature. The dependence of the spectrum on the target properties and the incidence angle is investigated with 2D PIC simulations. We base our work on widely available technologies and on laser with a short pulse, having in mind a facility whose cost is approximately 15M€. Using a recent experiment as the reference, we choose the laser pulse and target so that the energy spectrum obtained from the 3D PIC simulation is close to the one observed, whose cutoff energy was estimated to be over 50 MeV. Laser accelerated protons in the TNSA regime have wide energy spectrum and broad divergence. In this paper we compare three transport lines, designed to perform energy selection and beam collimation. They are based on a solenoid, a quadruplet of permanent magnetic quadrupoles and a chicane. To increase the maximum available energy, which is actually seen as an upper limit due to laser properties and available targets, we propose to inject protons into a small linac for post-acceleration. The number of selected and injected protons is the highest with the solenoid and lower by one and two orders of magnitude with the quadrupoles and the chicane respectively. Even though only the solenoid enables achieving to reach a final intensity at the threshold required for therapy with the highest beam quality, the other systems will be very likely used in the first experiments. Realistic start-to-end simulations, as the ones reported here, are relevant for the design of such experiments.

  10. High quality proton beams from hybrid integrated laser-driven ion acceleration systems

    Science.gov (United States)

    Sinigardi, Stefano; Turchetti, Giorgio; Rossi, Francesco; Londrillo, Pasquale; Giove, Dario; De Martinis, Carlo; Bolton, Paul R.

    2014-03-01

    We consider a hybrid acceleration scheme for protons where the laser generated beam is selected in energy and angle and injected into a compact linac, which raises the energy from 30 to 60 MeV. The laser acceleration regime is TNSA and the energy spectrum is determined by the cutoff energy and proton temperature. The dependence of the spectrum on the target properties and the incidence angle is investigated with 2D PIC simulations. We base our work on widely available technologies and on laser with a short pulse, having in mind a facility whose cost is approximately 15 M €. Using a recent experiment as the reference, we choose the laser pulse and target so that the energy spectrum obtained from the 3D PIC simulation is close to the one observed, whose cutoff energy was estimated to be over 50 MeV. Laser accelerated protons in the TNSA regime have wide energy spectrum and broad divergence. In this paper we compare three transport lines, designed to perform energy selection and beam collimation. They are based on a solenoid, a quadruplet of permanent magnetic quadrupoles and a chicane. To increase the maximum available energy, which is actually seen as an upper limit due to laser properties and available targets, we propose to inject protons into a small linac for post-acceleration. The number of selected and injected protons is the highest with the solenoid and lower by one and two orders of magnitude with the quadrupoles and the chicane respectively. Even though only the solenoid enables achieving to reach a final intensity at the threshold required for therapy with the highest beam quality, the other systems will be very likely used in the first experiments. Realistic start-to-end simulations, as the ones reported here, are relevant for the design of such experiments.

  11. High quality proton beams from hybrid integrated laser-driven ion acceleration systems

    International Nuclear Information System (INIS)

    Sinigardi, Stefano; Turchetti, Giorgio; Rossi, Francesco; Londrillo, Pasquale; Giove, Dario; De Martinis, Carlo; Bolton, Paul R.

    2014-01-01

    We consider a hybrid acceleration scheme for protons where the laser generated beam is selected in energy and angle and injected into a compact linac, which raises the energy from 30 to 60 MeV. The laser acceleration regime is TNSA and the energy spectrum is determined by the cutoff energy and proton temperature. The dependence of the spectrum on the target properties and the incidence angle is investigated with 2D PIC simulations. We base our work on widely available technologies and on laser with a short pulse, having in mind a facility whose cost is approximately 15M€. Using a recent experiment as the reference, we choose the laser pulse and target so that the energy spectrum obtained from the 3D PIC simulation is close to the one observed, whose cutoff energy was estimated to be over 50 MeV. Laser accelerated protons in the TNSA regime have wide energy spectrum and broad divergence. In this paper we compare three transport lines, designed to perform energy selection and beam collimation. They are based on a solenoid, a quadruplet of permanent magnetic quadrupoles and a chicane. To increase the maximum available energy, which is actually seen as an upper limit due to laser properties and available targets, we propose to inject protons into a small linac for post-acceleration. The number of selected and injected protons is the highest with the solenoid and lower by one and two orders of magnitude with the quadrupoles and the chicane respectively. Even though only the solenoid enables achieving to reach a final intensity at the threshold required for therapy with the highest beam quality, the other systems will be very likely used in the first experiments. Realistic start-to-end simulations, as the ones reported here, are relevant for the design of such experiments

  12. Space charge and beam stability issues of the Fermilab proton driver in Phase I

    Energy Technology Data Exchange (ETDEWEB)

    K. Y. Ng

    2001-08-24

    Issues concerning beam stability of the proposed Fermilab Proton Driver are studied in its Phase I. Although the betatron tune shifts are dominated by space charge, these shifts are less than 0.25 and will therefore not drive the symmetric and antisymmetric modes of the beam envelope into instability. The longitudinal space charge force is large and inductive inserts may be needed to compensate for the distortion of the rf potential. Although the longitudinal impedance is space charge dominated, it will not drive any microwave instability, unless the real part of the impedance coming from the inductive inserts and wall resistivity of the beam tube are large enough. The design of the beam tube is therefore very important in order to limit the flow of eddy current and keep wall resistivity low. The transverse impedance is also space charge dominated. With the Proton Driver operated at an imaginary transition gamma, however, Landau damping will never be canceled and beam stability can be maintained with negative chromaticities.

  13. Isochoric heating of DT fuels through PW-laser-produced proton beams

    International Nuclear Information System (INIS)

    Maynard, G.; Barriga-Carrasco, M.D.

    2005-01-01

    Laser Proton Source (LPS) can generate short bunch of energetic protons with a nearly zero initial emittance. It is thus expected that LPS can deposit a very high density of energy inside dense matter, in particular, in the context of fast ignition of an inertial fusion target. We investigate here one of the factors that can limit the density of deposited energy. It concerns the transverse diffusion, occurring during the transport between the LPS and DT. As the rear surface of LPS should be efficiently protected, the proton along its path has to interact with a substantial amount of high-Z material. Therefore the induced transverse dispersion can become significant. The transport of the proton beam inside a plasma target is calculated using a numerical code, which main features are presented

  14. Isochoric heating of DT fuels through PW-laser-produced proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Maynard, G. [Laboratoire de Physique des Gaz et des Pasmas, CNRS UMR8578, bat. 210, Universite Paris XI, F-91405, Orsay (France)]. E-mail: gilles.maynard@pgp.u-psud.fr; Barriga-Carrasco, M.D. [Laboratoire de Physique des Gaz et des Pasmas, CNRS UMR8578, bat. 210, Universite Paris XI, F-91405, Orsay (France)

    2005-05-21

    Laser Proton Source (LPS) can generate short bunch of energetic protons with a nearly zero initial emittance. It is thus expected that LPS can deposit a very high density of energy inside dense matter, in particular, in the context of fast ignition of an inertial fusion target. We investigate here one of the factors that can limit the density of deposited energy. It concerns the transverse diffusion, occurring during the transport between the LPS and DT. As the rear surface of LPS should be efficiently protected, the proton along its path has to interact with a substantial amount of high-Z material. Therefore the induced transverse dispersion can become significant. The transport of the proton beam inside a plasma target is calculated using a numerical code, which main features are presented.

  15. High intensity negative proton beams from a SNICS ion source

    International Nuclear Information System (INIS)

    Evans, C.R.; Hollander, M.G.

    1991-01-01

    For the past year we have been involved in a project to develop an intense (> 100μA) negative proton beam from a SNICS (Source of Negative Ions by Cesium Sputtering) ion source. This report will cover how we accomplished and exceeded this goal by more than 40%. Included in these observations will be the following: A description of an effective method for making titanium hydride cathodes. How to overcome the limitations of the titanium hydride cathode. The modification of the SNICS source to improve output; including the installation of the conical ionizer and the gas cathode. A discussion of problems including: poisoning the proton beam with oxygen, alternative gas cathode materials, the clogging of the gas inlet, long burn-in times, and limited cathode life times. Finally, how to optimize source performance when using a gas cathode, and what is the mechanism by which a gas cathode operates; facts, fantasies, or myth

  16. Direct-current proton-beam measurements at Los Alamos

    International Nuclear Information System (INIS)

    Sherman, J.; Stevens, R.R.; Schneider, J.D.; Zaugg, T.

    1994-01-01

    Recently, a CW proton accelerator complex was moved from Chalk River Laboratories (CRL) to Los Alamos National Laboratory. This includes a 50-keV dc proton injector with a single-solenoid low-energy beam transport system (LEBT) and a CW 1.25-MeV, 267-MHz radiofrequency quadrupole (RFQ). The move was completed after CRL had achieved 55-mA CW operation at 1.25 MeV using 250-kW klystrode tubes to power the RFQ. These accelerator components are prototypes for the front end of a CW linac required for an accelerator-driven transmutation linac, and they provide early confirmation of some CW accelerator components. The injector (ion source and LEBT) and emittance measuring unit are installed and operational at Los Alamos. The dc microwave ion source has been operated routinely at 50-keV, 75-mA hydrogen-ion current. This ion source has demonstrated very good discharge and H 2 gas efficiencies, and sufficient reliability to complete CW RFQ measurements at CRL. Proton fraction of 75% has been measured with 550-W discharge power. This high proton fraction removes the need for an analyzing magnet. Proton LEBT emittance measurements completed at Los Alamos suggest that improved transmission through the RFQ may be achieved by increasing the solenoid focusing current. Status of the final CW RFQ operation at CRL and the installation of the RFQ at Los Alamos is given

  17. Magnetically scanned proton therapy beams: rationales and techniques

    International Nuclear Information System (INIS)

    Jones, D.T.L.; Schreuder, A.N.

    2000-01-01

    Perhaps the most important advantages of beam scanning systems for proton therapy in comparison with conventional passive beam spreading systems are: (1) Intensity modulation and inverse planning are possible. (2) There is negligible reduction in the range of the beam. (3) Integral dose is reduced as dose conformation to the proximal edge of the lesion is possible. (4) In principle no field-specific modifying devices are required. (5) There is less activation of the surroundings. (6) Scanning systems axe almost infinitely flexible. The main disadvantages include: (1) Scanning systems are more complicated and therefore potentially less reliable and more dangerous. (2) The development of such systems is more demanding in terms of cost, time and manpower. (3) More stable beams are required. (4) Dose and beam position monitoring are more difficult. (5) The problems associated with patient and organ movement axe more severe. There are several techniques which can be used for scanning. For lateral beam spreading, circular scanning (wobbling) or linear scanning can be done. In the latter case the beam can be scanned continuously or in a discrete fashion (spot scanning). Another possibility is to undertake the fastest scan in one dimension (strip scanning) and translate the patient or the scanning magnet in the other dimension. Depth variation is achieved by interposing degraders in the beam (cyclotrons) or by changing the beam energy (synchrotrons). The aim of beam scanning is to deliver a predetermined dose at any point in the body. Special safety precautions must be taken because of the high instantaneous dose rates. The beam position and the dose delivered at each point must be accurately and redundantly determined. (author)

  18. Innovative thin silicon detectors for monitoring of therapeutic proton beams: preliminary beam tests

    Science.gov (United States)

    Vignati, A.; Monaco, V.; Attili, A.; Cartiglia, N.; Donetti, M.; Fadavi Mazinani, M.; Fausti, F.; Ferrero, M.; Giordanengo, S.; Hammad Ali, O.; Mandurrino, M.; Manganaro, L.; Mazza, G.; Sacchi, R.; Sola, V.; Staiano, A.; Cirio, R.; Boscardin, M.; Paternoster, G.; Ficorella, F.

    2017-12-01

    To fully exploit the physics potentials of particle therapy in delivering dose with high accuracy and selectivity, charged particle therapy needs further improvement. To this scope, a multidisciplinary project (MoVeIT) of the Italian National Institute for Nuclear Physics (INFN) aims at translating research in charged particle therapy into clinical outcome. New models in the treatment planning system are being developed and validated, using dedicated devices for beam characterization and monitoring in radiobiological and clinical irradiations. Innovative silicon detectors with internal gain layer (LGAD) represent a promising option, overcoming the limits of currently used ionization chambers. Two devices are being developed: one to directly count individual protons at high rates, exploiting the large signal-to-noise ratio and fast collection time in small thicknesses (1 ns in 50 μm) of LGADs, the second to measure the beam energy with time-of-flight techniques, using LGADs optimized for excellent time resolutions (Ultra Fast Silicon Detectors, UFSDs). The preliminary results of first beam tests with therapeutic beam will be presented and discussed.

  19. Fabrication of Faraday Cup Array for the Measurement of 2-Dimensional Proton Beam Profile

    International Nuclear Information System (INIS)

    Jung, Myunghwan; Kim, Bom Sok; Kim, Kyeryung

    2014-01-01

    It has an advantage of easy-to-use and possible to visually check, immediately; on the other hand, the measurement range is very limited. Another method is using the CCD camera-scintillator device such as p43 phosphor screen or chromox. A variety of faraday cup detectors have been recently introduced. The faraday cup is one of the powerful and popular tools for the measurement of beam current. By using several faraday cups in array geometry, it is possible to observe current distribution. In this study, we developed an external faraday cup array for the measure the beam current and profile at a KOMAC (Korea Multi-purpose Accelerator Complex) beam utilization facility. To measure the beam profile, before fabrication of faraday cup array, we use gafchromic film. By making the faraday cup array we were able to reduce the consumption of Gafchromic film and a more accurate diagnosis of the proton beam is possible. The use of faraday cup array, experiment using the proton beam is more reliable and confident

  20. Proton radiation therapy for retinoblastoma: Comparison of various intraocular tumor locations and beam arrangements

    International Nuclear Information System (INIS)

    Krengli, Marco; Hug, Eugen B.; Adams, Judy A.; Smith, Alfred R.; Tarbell, Nancy J.; Munzenrider, John E.

    2005-01-01

    Purpose: To study the optimization of proton beam arrangements for various intraocular tumor locations; and to correlate isodose distributions with various target and nontarget structures. Methods and materials: We considered posterior-central, nasal, and temporal tumor locations, with straight, intrarotated, or extrarotated eye positions. Doses of 46 cobalt grey equivalent (CGE) to gross tumor volume (GTV) and 40 CGE to clinical target volume (CTV) (2 CGE per fraction) were assumed. Using three-dimensional planning, we compared isodose distributions for lateral, anterolateral oblique, and anteromedial oblique beams and dose-volume histograms of CTVs, GTVs, lens, lacrimal gland, bony orbit, and soft tissues. Results: All beam arrangements fully covered GTVs and CTVs with optimal lens sparing. Only 15% of orbital bone received doses ≥20 CGE with a lateral beam, with 20-26 CGE delivered to two of three growth centers. The anterolateral oblique approach with an intrarotated eye resulted in additional reduction of bony volume and exposure of only one growth center. No appreciable dose was delivered to the contralateral eye, brain tissue, or pituitary gland. Conclusions: Proton therapy achieved homogeneous target coverage with true lens sparing. Doses to orbit structures, including bony growth centers, were minimized with different beam arrangements and eye positions. Proton therapy could reduce the risks of second malignancy and cosmetic and functional sequelae

  1. Proton storage rings

    International Nuclear Information System (INIS)

    Rau, R.R.

    1978-04-01

    A discussion is given of proton storage ring beam dynamic characteristics. Topics considered include: (1) beam energy; (2) beam luminosity; (3) limits on beam current; (4) beam site; (5) crossing angle; (6) beam--beam interaction; (7) longitudinal instability; (8) effects of scattering processes; (9) beam production; and (10) high magnetic fields. Much of the discussion is related to the design parameters of ISABELLE, a 400 x 400 GeV proton---proton intersecting storage accelerator to be built at Brookhaven National Laboratory

  2. Monte Carlo investigation of the low-dose envelope from scanned proton pencil beams

    International Nuclear Information System (INIS)

    Sawakuchi, Gabriel O; Titt, Uwe; Mirkovic, Dragan; Ciangaru, George; Zhu, X Ronald; Sahoo, Narayan; Gillin, Michael T; Mohan, Radhe

    2010-01-01

    Scanned proton pencil beams carry a low-dose envelope that extends several centimeters from the individual beam's central axis. Thus, the total delivered dose depends on the size of the target volume and the corresponding number and intensity of beams necessary to cover the target volume uniformly. This dependence must be considered in dose calculation algorithms used by treatment planning systems. In this work, we investigated the sources of particles contributing to the low-dose envelope using the Monte Carlo technique. We used a validated model of our institution's scanning beam line to determine the contributions to the low-dose envelope from secondary particles created in a water phantom and particles scattered in beam line components. Our results suggested that, for high-energy beams, secondary particles produced by nuclear interactions in the water phantom are the major contributors to the low-dose envelope. For low-energy beams, the low-dose envelope is dominated by particles undergoing multiple Coulomb scattering in the beam line components and water phantom. Clearly, in the latter situation, the low-dose envelope depends directly on beam line design features. Finally, we investigated the dosimetric consequences of the low-dose envelope. Our results showed that if not modeled properly the low-dose envelope may cause clinically relevant dose disturbance in the target volume. This work suggested that this low-dose envelope is beam line specific for low-energy beams, should be thoroughly experimentally characterized and validated during commissioning of the treatment planning system, and therefore is of great concern for accurate delivery of proton scanning beam doses.

  3. Deformable motion reconstruction for scanned proton beam therapy using on-line x-ray imaging

    NARCIS (Netherlands)

    Zhang, Ye; Knopf, A; Tanner, Colby; Boye, Dirk; Lomax, Antony J.

    2013-01-01

    Organ motion is a major problem for any dynamic radiotherapy delivery technique, and is particularly so for spot scanned proton therapy. On the other hand, the use of narrow, magnetically deflected proton pencil beams is potentially an ideal delivery technique for tracking tumour motion on-line. At

  4. SU-F-T-209: Multicriteria Optimization Algorithm for Intensity Modulated Radiation Therapy Using Pencil Proton Beam Scanning

    Energy Technology Data Exchange (ETDEWEB)

    Beltran, C; Kamal, H [Mayo Clinic, Rochester, MN (United States)

    2016-06-15

    Purpose: To provide a multicriteria optimization algorithm for intensity modulated radiation therapy using pencil proton beam scanning. Methods: Intensity modulated radiation therapy using pencil proton beam scanning requires efficient optimization algorithms to overcome the uncertainties in the Bragg peaks locations. This work is focused on optimization algorithms that are based on Monte Carlo simulation of the treatment planning and use the weights and the dose volume histogram (DVH) control points to steer toward desired plans. The proton beam treatment planning process based on single objective optimization (representing a weighted sum of multiple objectives) usually leads to time-consuming iterations involving treatment planning team members. We proved a time efficient multicriteria optimization algorithm that is developed to run on NVIDIA GPU (Graphical Processing Units) cluster. The multicriteria optimization algorithm running time benefits from up-sampling of the CT voxel size of the calculations without loss of fidelity. Results: We will present preliminary results of Multicriteria optimization for intensity modulated proton therapy based on DVH control points. The results will show optimization results of a phantom case and a brain tumor case. Conclusion: The multicriteria optimization of the intensity modulated radiation therapy using pencil proton beam scanning provides a novel tool for treatment planning. Work support by a grant from Varian Inc.

  5. SU-F-T-209: Multicriteria Optimization Algorithm for Intensity Modulated Radiation Therapy Using Pencil Proton Beam Scanning

    International Nuclear Information System (INIS)

    Beltran, C; Kamal, H

    2016-01-01

    Purpose: To provide a multicriteria optimization algorithm for intensity modulated radiation therapy using pencil proton beam scanning. Methods: Intensity modulated radiation therapy using pencil proton beam scanning requires efficient optimization algorithms to overcome the uncertainties in the Bragg peaks locations. This work is focused on optimization algorithms that are based on Monte Carlo simulation of the treatment planning and use the weights and the dose volume histogram (DVH) control points to steer toward desired plans. The proton beam treatment planning process based on single objective optimization (representing a weighted sum of multiple objectives) usually leads to time-consuming iterations involving treatment planning team members. We proved a time efficient multicriteria optimization algorithm that is developed to run on NVIDIA GPU (Graphical Processing Units) cluster. The multicriteria optimization algorithm running time benefits from up-sampling of the CT voxel size of the calculations without loss of fidelity. Results: We will present preliminary results of Multicriteria optimization for intensity modulated proton therapy based on DVH control points. The results will show optimization results of a phantom case and a brain tumor case. Conclusion: The multicriteria optimization of the intensity modulated radiation therapy using pencil proton beam scanning provides a novel tool for treatment planning. Work support by a grant from Varian Inc.

  6. A zero-to-few-hundred eV proton beam for calibrations of neutron beta decay experiments

    CERN Document Server

    Naab, F; Zech, W; García, A; Mumm, P

    2002-01-01

    We have constructed a system using a duoplasmatron source to produce a beam of low-energy (0 - few hundred eV) protons with the principal goal of testing and calibrating detectors used to detect protons from neutron beta decay. The system is stable and produces beams by simply turning on the associated power supplies without the need of careful tuning. As an example we show data from calibration of a surface barrier detector in the emiT apparatus. Protons from the system were scattered from an Al target and used to calibrate detectors in the emiT apparatus.

  7. Target irradiation facility and targetry development at 160 MeV proton beam of Moscow linac

    CERN Document Server

    Zhuikov, B L; Konyakhin, N A; Vincent, J

    1999-01-01

    A facility has been built and successfully operated with the 160 MeV proton beam of Moscow Meson factory LINAC, Institute for Nuclear Research (INR) of Russian Academy of Science, Troitsk. The facility was created for various isotope production goals as well as for fundamental nuclear investigations at high intensity beam (100 mu A and more). An important part of the facility targetry system is a high-intensity beam monitoring collimator device. Measurements of the temperature distribution between collimator sectors, cooling water flow and temperature, and the beam current, provide an opportunity to compute beam losses and beam position. The target holder design allows easy insertion by manipulator and simultaneous bombardment of several different targets of various types and forms, and variation of proton energy on each target over a wide range below 160 MeV. The main target utilized for commercial sup 8 sup 2 Sr isotope production is metallic rubidium in a stainless-steel container. A regular wet chemistry ...

  8. Effects of an energy broadened proton beam on the neutron distribution for the "7Li(p,n)"7Be reaction near threshold

    International Nuclear Information System (INIS)

    Shor, A.; Eisen, Y.; Berkovits, D.; Hirsh, T.; Feinberg, G.; Friedman, M.; Paul, M.; Krasa, A.; Giorginis, G.; Plompen, A.

    2011-01-01

    A common method for simulating the thermal neutron conditions in the stellar interior is based on the "7Li(p,n)"7Be reaction near threshold energy. Maxwellian-averaged neutron capture cross-sections of mean energy 25 keV, relevant to the s-process nucleosynthesis, are measured at existing Van-de-Graaff (VdG) proton accelerators. Soreq NRC Applied Research superconducting linear Accelerator Facility (SARAF) phase 1 is in its final stage of commissioning. Maxwellian averaged neutron capture cross-section measurements are planned to be conducted using a forced-flow closed-loop liquid-lithium target (LiLiT). The proton beam energy spread of RF linear accelerators, such as SARAF, is typically larger than the spread of proton beams of VdG accelerators. The energy spread of SARAF proton beam at 1912 keV is calculated to be of the order of 20-40 keV FWHM as compared to about 3 keV FWHM for VdG accelerators. For simulating the SARAF proton beam we performed an experiment at the IRMM-Geel VdG using a gold foil degrader positioned before the LiF target. This degrader shifts the mean proton energy to 1912 keV and it broadens the proton beam energy to values simulating the spread of the proton beam at SARAF. For calibrating the cross-sections we also performed a "7Li(p,n)"7Be experiment without the gold foil degrader at a proton energy of 1912 keV. The VdG was operated in a pulse mode and the neutron energies were determined by time-of-flight measurements using "6Li glass detectors. Detector efficiencies were obtained by Monte Carlo calculations. We present our study and compare the results for both narrow and broad energy proton beams. It is shown that the energy distribution for the broad-energy beam with a spread of 15 keV is similar to that of the distribution of the narrow energy beam and they peak nearly at the same energy. The broad-energy distribution has a tail extending to higher energies than that of the narrow-energy beam. It appears also that the neutron

  9. Study of the effects of high-energy proton beams on escherichia coli

    Science.gov (United States)

    Park, Jeong Chan; Jung, Myung-Hwan

    2015-10-01

    Antibiotic-resistant bacterial infection is one of the most serious risks to public health care today. However, discouragingly, the development of new antibiotics has progressed little over the last decade. There is an urgent need for alternative approaches to treat antibiotic-resistant bacteria. Novel methods, which include photothermal therapy based on gold nano-materials and ionizing radiation such as X-rays and gamma rays, have been reported. Studies of the effects of high-energy proton radiation on bacteria have mainly focused on Bacillus species and its spores. The effect of proton beams on Escherichia coli (E. coli) has been limitedly reported. Escherichia coli is an important biological tool to obtain metabolic and genetic information and is a common model microorganism for studying toxicity and antimicrobial activity. In addition, E. coli is a common bacterium in the intestinal tract of mammals. In this research, the morphological and the physiological changes of E. coli after proton irradiation were investigated. Diluted solutions of cells were used for proton beam radiation. LB agar plates were used to count the number of colonies formed. The growth profile of the cells was monitored by using the optical density at 600 nm. The morphology of the irradiated cells was observed with an optical microscope. A microarray analysis was performed to examine the gene expression changes between irradiated samples and control samples without irradiation. E coli cells have observed to be elongated after proton irradiation with doses ranging from 13 to 93 Gy. Twenty-two were up-regulated more than twofold in proton-irradiated samples (93 Gy) compared with unexposed one.

  10. Commissioning of a compact laser-based proton beam line for high intensity bunches around 10Â MeV

    Science.gov (United States)

    Busold, S.; Schumacher, D.; Deppert, O.; Brabetz, C.; Kroll, F.; Blažević, A.; Bagnoud, V.; Roth, M.

    2014-03-01

    We report on the first results of experiments with a new laser-based proton beam line at the GSI accelerator facility in Darmstadt. It delivers high current bunches at proton energies around 9.6 MeV, containing more than 109 particles in less than 10 ns and with tunable energy spread down to 2.7% (ΔE/E0 at FWHM). A target normal sheath acceleration stage serves as a proton source and a pulsed solenoid provides for beam collimation and energy selection. Finally a synchronous radio frequency (rf) field is applied via a rf cavity for energy compression at a synchronous phase of -90 deg. The proton bunch is characterized at the end of the very compact beam line, only 3 m behind the laser matter interaction point, which defines the particle source.

  11. Proton therapy device

    International Nuclear Information System (INIS)

    Tronc, D.

    1994-01-01

    The invention concerns a proton therapy device using a proton linear accelerator which produces a proton beam with high energies and intensities. The invention lies in actual fact that the proton beam which is produced by the linear accelerator is deflected from 270 deg in its plan by a deflecting magnetic device towards a patient support including a bed the longitudinal axis of which is parallel to the proton beam leaving the linear accelerator. The patient support and the deflecting device turn together around the proton beam axis while the bed stays in an horizontal position. The invention applies to radiotherapy. 6 refs., 5 figs

  12. The potential of proton beam radiation therapy in intracranial and ocular tumours

    Energy Technology Data Exchange (ETDEWEB)

    Blomquist, Erik [Univ. Hospital, Uppsala (Sweden). Dept. of Oncology, Radiology and Clinical Immunology; Bjelkengren, Goeran [Univ. Hospital, Malmoe (Sweden). Dept. of Oncology; Glimelius, Bengt [Karolinska Inst., Stockholm (Sweden). Dept. of Oncology and Pathology; Akademiska sjukhuset, Uppsala (Sweden). Dept. of Oncology, Radiology and Clinical Immunology

    2005-12-01

    A group of oncologists and hospital physicists have estimated the number of patients in Sweden suitable for proton beam therapy. The estimations have been based on current statistics of tumour incidence, number of patients potentially eligible for radiation treatment, scientific support from clinical trials and model dose planning studies and knowledge of the dose-response relations of different tumours and normal tissues. In intracranial benign and malignant tumours, it is estimated that between 130 and 180 patients each year are candidates for proton beam therapy. Of these, between 50 and 75 patients have malignant glioma, 30-40 meningeoma, 20-25 arteriovenous malformations, 20-25 skull base tumours and 10-15 pituitary adenoma. In addition, 15 patients with ocular melanoma are candidates.

  13. Material studies for pulsed high-intensity proton beam targets

    International Nuclear Information System (INIS)

    Simos, N.; Kirk, H.; Ludewig, H.; Thieberger, P.; Weng, W-T.; McDonald, K.; Yoshimura, K.

    2004-01-01

    Intense beams for muon colliders and neutrino facilities require high-performance target stations of 1-4 MW proton beams. The physics requirements for such a system push the envelope of our current knowledge as to how materials behave under high-power beams for both short and long exposure. The success of an adopted scheme that generates, captures and guides secondary particles depends on the useful life expectancy of this critical system. This paper presents an overview of what has been achieved during the various phases of the experimental effort including a tentative plan to continue the effort by expanding the material matrix. The first phase of the project was to study the changes after irradiation in mechanical properties and specially in thermal expansion coefficient of various materials. During phase-I the study attention was primarily focused on Super-invar and in a lesser degree on Inconel-718. Invar is a metal alloy which predominantly consists of 62% Fe, 32% Ni and 5% Co. It is showed that this metal, whose non-irradiated properties held such promise, can only be considered a serious target candidate for an intense proton beam only if one can anneal the atomic displacements followed by the appropriate heat treatment to restore its favorable expansion coefficient. New materials that have been developed for various industrial needs by optimizing key properties, might be of value for the accelerator community. These materials like carbon-carbon composites, titanium alloys, the Toyota 'gum metal', the Vascomax material and the AlBeMet alloy will be explored and tested in the second phase of the project. (A.C.)

  14. Decursin reduce radio-resistance of hypoxic regions under the proton beam therapy by induced HIF-1α degradation

    International Nuclear Information System (INIS)

    Jung, Myung Hwan; Kim, Kye Ryung

    2013-01-01

    Protons induce cancer-cell apoptosis in vitro and block blood vessel formation in vivo through the generation of reactive oxygen species (ROS). The fact that proton severely inhibits blood vessel development in zebrafish embryos suggests a higher sensitivity of vascular endothelial cells to proton beam. Decursin, a coumarin compound, was originally isolated from Angelica gigas Nakai (Dang Gui). A. gigas root has been traditionally used in Korean folk medicine for the treatment of anemia and other common diseases. In previous reports, decursin was reported to exhibit anti-tumor activity against various cancer cells and to inhibit the activities of the androgen and androgen-receptor (AR) signaling pathway in prostate cancer, induction of cell cycle arrest and apoptosis in various cancer cells, such as prostate, breast, bladder, and colon cancer cells. Decursin also inhibits VEGF-induced angiogenesis through the suppression of the VEGFR-2-signaling pathway. However, the mechanism of decursin mediates change of HIF-1α activities is not clear. In this research, we identified regulations of the HIF-1α and the anti-angiogenesis effects of decursin in proton-beam-irradiated human lung cancer, prostate cancer and Hepatic cancer cells. We investigated the underlying mechanisms of positive effects of protonbeam-induced anti-angiogenesis. Our data indicate that the groups co-treated with decursin and a proton-beam had significant reduced HIF-1α activity compared with the groups treated with only a proton beam under the hypoxic condition caused by DFX(desferrioxamine). Decursin was found to induced HIF-1α degradation. Therefore, we suggest that decursin may be a potential candidate for use as a sensitizer for proton-beaminduced cell apoptosis. Here we have shown that decursin successfully reduced HIF-1α stability under hypoxic condition by induced desferrioxamine. We showed novel candidates for anti-angiogenic compound, decursin, leading to complete inhibition of radio

  15. Decursin reduce radio-resistance of hypoxic regions under the proton beam therapy by induced HIF-1α degradation

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Myung Hwan; Kim, Kye Ryung [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    Protons induce cancer-cell apoptosis in vitro and block blood vessel formation in vivo through the generation of reactive oxygen species (ROS). The fact that proton severely inhibits blood vessel development in zebrafish embryos suggests a higher sensitivity of vascular endothelial cells to proton beam. Decursin, a coumarin compound, was originally isolated from Angelica gigas Nakai (Dang Gui). A. gigas root has been traditionally used in Korean folk medicine for the treatment of anemia and other common diseases. In previous reports, decursin was reported to exhibit anti-tumor activity against various cancer cells and to inhibit the activities of the androgen and androgen-receptor (AR) signaling pathway in prostate cancer, induction of cell cycle arrest and apoptosis in various cancer cells, such as prostate, breast, bladder, and colon cancer cells. Decursin also inhibits VEGF-induced angiogenesis through the suppression of the VEGFR-2-signaling pathway. However, the mechanism of decursin mediates change of HIF-1α activities is not clear. In this research, we identified regulations of the HIF-1α and the anti-angiogenesis effects of decursin in proton-beam-irradiated human lung cancer, prostate cancer and Hepatic cancer cells. We investigated the underlying mechanisms of positive effects of protonbeam-induced anti-angiogenesis. Our data indicate that the groups co-treated with decursin and a proton-beam had significant reduced HIF-1α activity compared with the groups treated with only a proton beam under the hypoxic condition caused by DFX(desferrioxamine). Decursin was found to induced HIF-1α degradation. Therefore, we suggest that decursin may be a potential candidate for use as a sensitizer for proton-beaminduced cell apoptosis. Here we have shown that decursin successfully reduced HIF-1α stability under hypoxic condition by induced desferrioxamine. We showed novel candidates for anti-angiogenic compound, decursin, leading to complete inhibition of radio

  16. Microdosimetric Characteristics of the Clinical Proton Beams at JIRN, Dubna

    Czech Academy of Sciences Publication Activity Database

    Molokanov, A. G.; Běgusová, Marie; Spurný, František; Vlček, Bohumil

    2002-01-01

    Roč. 99, 1-4 (2002), s. 433-434 ISSN 0144-8420 R&D Projects: GA ČR GA202/01/0710 Institutional research plan: CEZ:AV0Z1048901 Keywords : microdosimetry * proton beams * biological efficiency Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 0.555, year: 2002

  17. ISABELLE: a 400 x 400 GeV proton--proton colliding beam facility

    International Nuclear Information System (INIS)

    1978-01-01

    A conceptual design report is presented for the construction of an Intersecting Storage Accelerator, ISABELLE, to be located at Brookhaven National Laboratory. At this major research facility beams of protons with energies up to 400 GeV will be collided in six experimental areas. At each area particle physicists will install detector apparatus to study the interaction and reaction products for such very high energy collisions. The proposal results from several years of study and development work on such a facility. Topics discussed include: (1) introduction and summary of the proposal; (2) physics at ISABELLE (including physics objectives and typical experiments and detectors); description of ISABELLE (overview; magnetic ring structure and lattice characteristics; performance; beam transfer, stacking, and acceleration; magnet system; refrigeration system; vacuum system; power supplies, instrumentation, and control system; physical plant and experimental halls; and operation and safety); and (3) cost estimate and schedule

  18. ISABELLE: a 400 x 400 GeV proton--proton colliding beam facility

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-01

    A conceptual design report is presented for the construction of an Intersecting Storage Accelerator, ISABELLE, to be located at Brookhaven National Laboratory. At this major research facility beams of protons with energies up to 400 GeV will be collided in six experimental areas. At each area particle physicists will install detector apparatus to study the interaction and reaction products for such very high energy collisions. The proposal results from several years of study and development work on such a facility. Topics discussed include: (1) introduction and summary of the proposal; (2) physics at ISABELLE (including physics objectives and typical experiments and detectors); description of ISABELLE (overview; magnetic ring structure and lattice characteristics; performance; beam transfer, stacking, and acceleration; magnet system; refrigeration system; vacuum system; power supplies, instrumentation, and control system; physical plant and experimental halls; and operation and safety); and (3) cost estimate and schedule.

  19. A Novel Approach to Postmastectomy Radiation Therapy Using Scanned Proton Beams

    Energy Technology Data Exchange (ETDEWEB)

    Depauw, Nicolas, E-mail: ndepauw@partners.org [Francis H. Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Centre for Medical Radiation Physics, University of Wollongong, New South Wales (Australia); Batin, Estelle; Daartz, Julianne [Francis H. Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Rosenfeld, Anatoly [Centre for Medical Radiation Physics, University of Wollongong, New South Wales (Australia); Adams, Judith; Kooy, Hanne; MacDonald, Shannon; Lu, Hsiao-Ming [Francis H. Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2015-02-01

    Purpose: Postmastectomy radiation therapy (PMRT), currently offered at Massachusetts General Hospital, uses proton pencil beam scanning (PBS) with intensity modulation, achieving complete target coverage of the chest wall and all nodal regions and reduced dose to the cardiac structures. This work presents the current methodology for such treatment and the ongoing effort for its improvements. Methods and Materials: A single PBS field is optimized to ensure appropriate target coverage and heart/lung sparing, using an in–house-developed proton planning system with the capability of multicriteria optimization. The dose to the chest wall skin is controlled as a separate objective in the optimization. Surface imaging is used for setup because it is a suitable surrogate for superficial target volumes. In order to minimize the effect of beam range uncertainties, the relative proton stopping power ratio of the material in breast implants was determined through separate measurements. Phantom measurements were also made to validate the accuracy of skin dose calculation in the treatment planning system. Additionally, the treatment planning robustness was evaluated relative to setup perturbations and patient breathing motion. Results: PBS PMRT planning resulted in appropriate target coverage and organ sparing, comparable to treatments by passive scattering (PS) beams but much improved in nodal coverage and cardiac sparing compared to conventional treatments by photon/electron beams. The overall treatment time was much shorter than PS and also shorter than conventional photon/electron treatment. The accuracy of the skin dose calculation by the planning system was within ±2%. The treatment was shown to be adequately robust relative to both setup uncertainties and patient breathing motion, resulting in clinically satisfying dose distributions. Conclusions: More than 25 PMRT patients have been successfully treated at Massachusetts General Hospital by using single-PBS fields

  20. A Novel Approach to Postmastectomy Radiation Therapy Using Scanned Proton Beams

    International Nuclear Information System (INIS)

    Depauw, Nicolas; Batin, Estelle; Daartz, Julianne; Rosenfeld, Anatoly; Adams, Judith; Kooy, Hanne; MacDonald, Shannon; Lu, Hsiao-Ming

    2015-01-01

    Purpose: Postmastectomy radiation therapy (PMRT), currently offered at Massachusetts General Hospital, uses proton pencil beam scanning (PBS) with intensity modulation, achieving complete target coverage of the chest wall and all nodal regions and reduced dose to the cardiac structures. This work presents the current methodology for such treatment and the ongoing effort for its improvements. Methods and Materials: A single PBS field is optimized to ensure appropriate target coverage and heart/lung sparing, using an in–house-developed proton planning system with the capability of multicriteria optimization. The dose to the chest wall skin is controlled as a separate objective in the optimization. Surface imaging is used for setup because it is a suitable surrogate for superficial target volumes. In order to minimize the effect of beam range uncertainties, the relative proton stopping power ratio of the material in breast implants was determined through separate measurements. Phantom measurements were also made to validate the accuracy of skin dose calculation in the treatment planning system. Additionally, the treatment planning robustness was evaluated relative to setup perturbations and patient breathing motion. Results: PBS PMRT planning resulted in appropriate target coverage and organ sparing, comparable to treatments by passive scattering (PS) beams but much improved in nodal coverage and cardiac sparing compared to conventional treatments by photon/electron beams. The overall treatment time was much shorter than PS and also shorter than conventional photon/electron treatment. The accuracy of the skin dose calculation by the planning system was within ±2%. The treatment was shown to be adequately robust relative to both setup uncertainties and patient breathing motion, resulting in clinically satisfying dose distributions. Conclusions: More than 25 PMRT patients have been successfully treated at Massachusetts General Hospital by using single-PBS fields

  1. Slip-stacking Dynamics for High-Power Proton Beams at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Eldred, Jeffrey Scott [Indiana Univ., Bloomington, IN (United States)

    2015-12-01

    Slip-stacking is a particle accelerator configuration used to store two particle beams with different momenta in the same ring. The two beams are longitudinally focused by two radiofrequency (RF) cavities with a small frequency difference between them. Each beam is synchronized to one RF cavity and perturbed by the other RF cavity. Fermilab uses slip-stacking in the Recycler so as to double the power of the 120 GeV proton beam in the Main Injector. This dissertation investigates the dynamics of slip-stacking beams analytically, numerically and experimentally. In the analytic analysis, I find the general trajectory of stable slip-stacking particles and identify the slip-stacking parametric resonances. In the numerical analysis, I characterize the stable phase-space area and model the particle losses. In particular, I evaluate the impact of upgrading the Fermilab Booster cycle-rate from 15 Hz to 20 Hz as part of the Proton Improvement Plan II (PIP-II). The experimental analysis is used to verify my approach to simulating slip-stacking loss. I design a study for measuring losses from the longitudinal single-particle dynamics of slip-stacking as a function of RF cavity voltage and RF frequency separation. I further propose the installation of a harmonic RF cavity and study the dynamics of this novel slip-stacking configuration. I show the harmonic RF cavity cancels out parametric resonances in slip-stacking, reduces emittance growth during slip-stacking, and dramatically enhances the stable phase-space area. The harmonic cavity is expected to reduce slip-stacking losses to far exceed PIP-II requirements. These results raise the possibility of extending slip-stacking beyond the PIP-II era.

  2. Preliminary assessment of LiF and alanine detectors for the dosimetry of proton therapy beams

    International Nuclear Information System (INIS)

    Fattibene, P.; Calicchia, A.; De Angelis, C.; Onori, S.; Egger, E.

    1996-01-01

    An experimental intercomparison between the proton response of LiF TLD-100 and alanine detectors is reported. The investigations were performed with LiF chips and alanine pellets in a 62 MeV proton beam at the Paul Scherrer Institut in Villigen (CH). Results were compared with reference dosimetry provided by Markus type parallel plate ionization chamber. The response of the detectors was studied, in a phantom, at different beam penetration depths in pristine and modulated beams. For both alanine and TL detectors, within the experimental uncertainty of the measurements, no significant energy dependence in the response was observed down to the Bragg peak region. The sensitivity of alanine and LiF detectors to protons was measured in the centre of modulated Bragg peak and no significant difference was found with respect to 60 Co. Contrary to LiF, alanine also offers a remarkable tissue equivalence which favours its choice for in-phantom dosimetry. (author)

  3. Definitive proton beam radiation therapy for inoperable gastric cancer

    International Nuclear Information System (INIS)

    Shibuya, Susumu; Takase, Yasuhiro; Aoyagi, Hiroyuki; Orii, Kazuo; Sharma, N.; Iwasaki, Yoji; Tsujii, Hirohiko; Tsujii, Hiroshi.

    1991-01-01

    Proton beam radiation therapy using 250 MeV protons was carried out on two patients with early gastric cancer (T1, N0, M0). One patient was an 85-year-old man with early gastric cancer of type IIa + IIc. The other one was a 70-year-old man with early gastric cancer of type IIc. In both cases histological examination of biopsy specimens showed differential adenocarcinoma; distant metastasis was not found by other examinations. Both patients were considered inoperable due to their poor cardiac and/or respiratory functions. Therefore, it was decided to treat them by definitive proton irradiation, delivering total doses of 86 Gy and 83 Gy, respectively. In both patients, skin erythema that did not require any special treatment was found in the irradiation field. Hematobiological examinations did not show any abnormality. Although endoscopic examination at two years after irradiation in the former case and at seven months in the latter case showed persistent gastric ulcer at the site of the cancerous lesions, cancer cells were not found histologically. Therefore, we concluded that proton irradiation therapy was useful for inoperable early gastric cancers. (author)

  4. ULTRA-LOW INTENSITY PROTON BEAMS FOR RADIATION RESPONSE RELATED EXPERIMENTS AT THE U-120M CYCLOTRON

    Directory of Open Access Journals (Sweden)

    Tomas Matlocha

    2018-05-01

    Full Text Available The U-120M cyclotron at the Nuclear Physics Institute (NPI of the Czech Academy of Sciences in Rez is used for radiation hardness tests of electronics for high-energy physics experiments. These tests are usually carried out with proton fluxes of the order of 105–109 proton·cm−2·s−1. Some tests done for the upgrade of the Inner Tracking System of the ALICE experiment at CERN, however, required proton beam intensities several orders of magnitude lower. This paper presents a method which has been developed to achieve the proton beam flux of the order of 1 proton · cm−2·s−1. The method is mainly based on reduction of the discharge current in the cyclotron internal Penning type ion source. Influence of this new operation mode on the lifetime of ion source cathodes is discussed.

  5. Medium energy high intensity proton accelerator (MEHIPA): Reference Design Report (RDR) Ver. 1.0

    International Nuclear Information System (INIS)

    2016-11-01

    Recent progress in accelerator technology has made it possible to use a proton accelerator to produce nuclear energy. In an accelerator-driven system (ADS), a high-intensity proton accelerator is used to produce protons of around 1 GeV energy, which strike a target such as lead or tungsten to produce spallation neutrons. ADS can be used to produce power, incinerate minor actinides and long-lived fission products, and for the utilization of thorium as an alternative nuclear fuel. The accelerator for ADS has to produce high energy (1 GeV) protons, and deliver tens of milli amperes of beam current with minimum (< 1 nA/m) beam loss for hands-on maintenance of the accelerator. This makes the development of accelerators for ADS very challenging. In India, it is planned to take a staged approach towards development of the requisite accelerator technology, and it is planned to develop the accelerator in three phases: 20 MeV, 200 MeV and 1 GeV. This report presents a reference design report for the Medium Energy High Intensity Proton Accelerator (MEHIPA) which will accelerate the beam to 200 MeV. The linac consists of a 3 MeV normal conducting RFQ followed by three families of superconducting Single Spoke Resonators (SSR) to accelerate the beam to 200 MeV. The major elements of the physics design of MEHIPA, as well as layouts and specifications of the major accelerator sub-systems are presented in this report. (author)

  6. Measurement of neutron yield by 62 MeV proton beam on a thick beryllium target

    Energy Technology Data Exchange (ETDEWEB)

    Osipenko, M., E-mail: osipenko@ge.infn.it [INFN, sezione di Genova, 16146 Genova (Italy); Ripani, M. [INFN, sezione di Genova, 16146 Genova (Italy); Alba, R. [INFN, Laboratori Nazionali del Sud, 95123 Catania (Italy); Ricco, G. [INFN, sezione di Genova, 16146 Genova (Italy); Schillaci, M. [INFN, Laboratori Nazionali del Sud, 95123 Catania (Italy); Barbagallo, M. [INFN, sezione di Bari, 70126 Bari (Italy); Boccaccio, P. [INFN, Laboratori Nazionali di Legnaro, 35020 Legnaro (Italy); Celentano, A. [Dipartimento di Fisica dell' Università di Genova, 16146 Genova (Italy); Colonna, N. [INFN, sezione di Bari, 70126 Bari (Italy); Cosentino, L.; Del Zoppo, A.; Di Pietro, A. [INFN, Laboratori Nazionali del Sud, 95123 Catania (Italy); Esposito, J. [INFN, Laboratori Nazionali di Legnaro, 35020 Legnaro (Italy); Figuera, P.; Finocchiaro, P. [INFN, Laboratori Nazionali del Sud, 95123 Catania (Italy); Kostyukov, A. [Moscow State University, Moscow 119992 (Russian Federation); Maiolino, C.; Santonocito, D.; Scuderi, V. [INFN, Laboratori Nazionali del Sud, 95123 Catania (Italy); Viberti, C.M. [Dipartimento di Fisica dell' Università di Genova, 16146 Genova (Italy)

    2013-09-21

    The design of a low-power prototype of neutron amplifier recently proposed within the INFN-E project indicated the need for more accurate data on the neutron yield produced by a proton beam with energy of about 70 MeV impinging on a thick beryllium target. Such measurement was performed at the LNS superconducting cyclotron, covering a wide angular range from 0° to 150° and a complete neutron energy interval from thermal to beam energy. Neutrons with energy above 0.5 MeV were measured by liquid scintillators exploiting their time of flight to determine the kinetic energy. For lower energy neutrons, down to thermal energy, a {sup 3}He detector was used. The obtained data are in good agreement with previous measurements at 0° using 66 MeV proton beam, covering neutron energies >10MeV, as well as with measurements at few selected angles using protons of 46, 55 and 113 MeV energy. The present results extend the neutron yield data in the 60–70 MeV beam energy range. A comparison of measured yields to MCNP, FLUKA and Geant4 Monte Carlo simulations was performed.

  7. Commissioning of a compact laser-based proton beam line for high intensity bunches around 10 MeV

    Directory of Open Access Journals (Sweden)

    S. Busold

    2014-03-01

    Full Text Available We report on the first results of experiments with a new laser-based proton beam line at the GSI accelerator facility in Darmstadt. It delivers high current bunches at proton energies around 9.6 MeV, containing more than 10^{9} particles in less than 10 ns and with tunable energy spread down to 2.7% (ΔE/E_{0} at FWHM. A target normal sheath acceleration stage serves as a proton source and a pulsed solenoid provides for beam collimation and energy selection. Finally a synchronous radio frequency (rf field is applied via a rf cavity for energy compression at a synchronous phase of -90  deg. The proton bunch is characterized at the end of the very compact beam line, only 3 m behind the laser matter interaction point, which defines the particle source.

  8. Theoretical detection limit of PIXE analysis using 20 MeV proton beams

    Science.gov (United States)

    Ishii, Keizo; Hitomi, Keitaro

    2018-02-01

    Particle-induced X-ray emission (PIXE) analysis is usually performed using proton beams with energies in the range 2∼3 MeV because at these energies, the detection limit is low. The detection limit of PIXE analysis depends on the X-ray production cross-section, the continuous background of the PIXE spectrum and the experimental parameters such as the beam currents and the solid angle and detector efficiency of X-ray detector. Though the continuous background increases as the projectile energy increases, the cross-section of the X-ray increases as well. Therefore, the detection limit of high energy proton PIXE is not expected to increase significantly. We calculated the cross sections of continuous X-rays produced in several bremsstrahlung processes and estimated the detection limit of a 20 MeV proton PIXE analysis by modelling the Compton tail of the γ-rays produced in the nuclear reactions, and the escape effect on the secondary electron bremsstrahlung. We found that the Compton tail does not affect the detection limit when a thin X-ray detector is used, but the secondary electron bremsstrahlung escape effect does have an impact. We also confirmed that the detection limit of the PIXE analysis, when used with 4 μm polyethylene backing film and an integrated beam current of 1 μC, is 0.4∼2.0 ppm for proton energies in the range 10∼30 MeV and elements with Z = 16-90. This result demonstrates the usefulness of several 10 MeV cyclotrons for performing PIXE analysis. Cyclotrons with these properties are currently installed in positron emission tomography (PET) centers.

  9. Acoustic signal generation in excised muscle by pulsed proton beam irradiation and the possibility of its clinical application to radiation therapy

    International Nuclear Information System (INIS)

    Hayakawa, Yoshinori; Tada, Junichiro; Inada, Tetsuo; Kitagawa, Toshio; Wagai, Toshio; Yoshioka, Katsuya.

    1989-01-01

    Acoustic signals generated in liquids and in metals by pulsed proton beam are thought to be thermal shock wave due to localized energy deposition of incident protons. Thus the intensity of generated acoustic signals is almost proportional to the energy deposited at the region. This suggests the possibility for measuring spatial distribution of energy deposition of proton beam using the acoustic method. In proton beam radiation therapy, treatment planning is developed from data of X-ray computer tomography which reflects the information on the electron density distribution in the patient's body. Ensuring the agreement of the dose distribution in the patient with the planned one, however, is difficult. It is expected that the acoustic method can provide a useful tool for this purpose. The pulsed proton beam of 50ns in pulse width is used for cancer therapy at the University of Tsukuba. A hydrophone is used to detect acoustic signals generated by pulsed proton beam. Detected signals are amplified ten thousand times before being averaged and analyzed by digital oscilloscope. Measurements made suggest that the method could be useful for radiation therapy. (N.K.)

  10. Beam forming system modernization at the MMF linac proton injector

    CERN Document Server

    Derbilov, V I; Nikulin, E S; Frolov, O T

    2001-01-01

    The isolation improvements of the beam forming system (BFS) of the MMF linac proton injector ion source are reported. The mean beam current and,accordingly, BFS electrode heating were increased when the MMF linac has began to operate regularly in long beam sessions with 50 Hz pulse repetition rate. That is why the BFS electrode high-voltage isolation that was made previously as two consequently and rigidly glued solid cylinder insulators has lost mechanical and electric durability. The substitution of large (160 mm) diameter cylinder insulator for four small diameter (20 mm) tubular rods has improved vacuum conditions in the space of beam forming and has allowed to operate without failures when beam currents being up to 250 mA and extraction and focusing voltage being up to 25 and 40 kV respectively. Moreover,the construction provides the opportunity of electrode axial move. The insulators are free from electrode thermal expansion mechanical efforts in a transverse direction.

  11. Measurement of characteristic prompt gamma rays emitted from oxygen and carbon in tissue-equivalent samples during proton beam irradiation.

    Science.gov (United States)

    Polf, Jerimy C; Panthi, Rajesh; Mackin, Dennis S; McCleskey, Matt; Saastamoinen, Antti; Roeder, Brian T; Beddar, Sam

    2013-09-07

    The purpose of this work was to characterize how prompt gamma (PG) emission from tissue changes as a function of carbon and oxygen concentration, and to assess the feasibility of determining elemental concentration in tissues irradiated with proton beams. For this study, four tissue-equivalent water-sucrose samples with differing densities and concentrations of carbon, hydrogen, and oxygen were irradiated with a 48 MeV proton pencil beam. The PG spectrum emitted from each sample was measured using a high-purity germanium detector, and the absolute detection efficiency of the detector, average beam current, and delivered dose distribution were also measured. Changes to the total PG emission from (12)C (4.44 MeV) and (16)O (6.13 MeV) per incident proton and per Gray of absorbed dose were characterized as a function of carbon and oxygen concentration in the sample. The intensity of the 4.44 MeV PG emission per incident proton was found to be nearly constant for all samples regardless of their carbon concentration. However, we found that the 6.13 MeV PG emission increased linearly with the total amount (in grams) of oxygen irradiated in the sample. From the measured PG data, we determined that 1.64 × 10(7) oxygen PGs were emitted per gram of oxygen irradiated per Gray of absorbed dose delivered with a 48 MeV proton beam. These results indicate that the 6.13 MeV PG emission from (16)O is proportional to the concentration of oxygen in tissue irradiated with proton beams, showing that it is possible to determine the concentration of oxygen within tissues irradiated with proton beams by measuring (16)O PG emission.

  12. Codes of practice and protocols for the dosimetry in reference conditions of proton and ion beams

    International Nuclear Information System (INIS)

    Vatnitsky, S.; Andreo, P.

    2002-01-01

    The advantages of radiotherapy protons and heavier charged-particle beams, the technological feasibility, and the clinical results obtained so far have led to the establishment of about 20 treatment facilities worldwide and plans to open another 20 proton and light-ion therapy centres in the next five years. In order to meet the expanding capabilities of treatment techniques, considerable effort has been devoted during the last fifteen years to the development of the dosimetry and calibration of such beams. This paper reviews these developments and summarizes the present status of Codes of Practice and protocols for the dosimetry in reference conditions of proton and ion beams. The first dosimetry protocol for heavy-particle radiotherapy beams, AAPM TG 20, was based on the use of Faraday cups and calorimeters, whereas ionization chamber dosimetry received little attention. Following the trends in 'nuclear particle' radiotherapy, TG 20 included recommendations for specifying 'dose to tissue'. The lack of availability of a harmonized set of data for the different particles made this protocol to include data for stopping-powers and for the mean energy required to produce and ion pair in air, W air , from multiple authors, without enough attention being paid to their consistency. The increased focus into proton beams was materialized in the publication of the ECHED Code of Practice, dedicated exclusively to protons, where ionization dosimetry received more attention than in TG 20. It was not until the publication of the Supplement to the ECHED recommendations that ionization chambers having a 60 CO calibration factor were recommended as a reference detector for proton dosimetry, and data supplied for chambers with different wall materials. The emphasis on ionization chamber-based proton dosimetry was complemented with a recommendation for using water as dosimetry phantom material and the necessary data on tissue and water to air stopping-power ratios and W air . One of

  13. SU-E-T-14: A Feasibility Study of Using Modified AP Proton Beam for Post-Operative Pancreatic Cancer Therapy

    International Nuclear Information System (INIS)

    Ding, X; Witztum, A; Kenton, O; Younan, F; Dormer, J; Kremmel, E; Lin, H; Liu, H; Tang, S; Both, S; Kassaee, A; Avery, S

    2014-01-01

    Purpose: Due to the unpredictability of bowel gas movement, the PA beam direction is always favored for robust proton therapy in post-operative pancreatic cancer treatment. We investigate the feasibility of replacing PA beam with a modified AP beam to take the bowel gas uncertainty into account. Methods: Nine post-operative pancreatic cancer patients treated with proton therapy (5040cGy, 28 fractions) in our institution were randomly selected. The original plan uses PA and lateral direction passive-scattering proton beams. Beam weighting is about 1:1. All patients received weekly verification CTs to assess the daily variations(total 17 verification CTs). The PA direction beam was replaced by two other groups of AP direction beam. Group AP: takes 3.5% range uncertainty into account. Group APmod: compensates the bowel gas uncertainty by expanding the proximal margin to 2cm more. The 2cm margin was acquired from the average bowel diameter in from 100 adult abdominal CT scans near pancreatic region (+/- 5cm superiorly and inferiorly). Dose Volume Histograms(DVHs) of the verification CTs were acquired for robustness study. Results: Without the lateral beam, Group APmod is as robust as Group PA. In Group AP, more than 10% of iCTV D98/D95 were reduced by 4–8%. LT kidney and Liver dose robustness are not affected by the AP/PA beam direction. There is 10% of chance that RT kidney and cord will be hit by AP proton beam due to the bowel gas. Compared to Group PA, APmod plan reduced the dose to kidneys and cord max significantly, while there is no statistical significant increase in bowel mean dose. Conclusion: APmod proton beam for the target coverage could be as robust as the PA direction without sacrificing too much of bowel dose. When the AP direction beam has to be selected, a 2cm proximal margin should be considered

  14. Method of measuring the polarization of high momentum proton beams

    International Nuclear Information System (INIS)

    Underwood, D.G.

    1976-01-01

    A method of measuring the polarization of high momentum proton beams is proposed. This method utilizes the Primakoff effect and relates asymmetries at high energy to large asymmetries already measured at low energy. Such a new method is essential for the success of future experiments at energies where present methods are no longer feasible

  15. WE-E-BRB-01: Personalized Motion Management Strategies for Pencil Beam Scanning Proton Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, X. [UT MD Anderson Cancer Center (United States)

    2016-06-15

    Strategies for treating thoracic and liver tumors using pencil beam scanning proton therapy Thoracic and liver tumors have not been treated with pencil beam scanning (PBS) proton therapy until recently. This is because of concerns about the significant interplay effects between proton spot scanning and patient’s respiratory motion. However, not all tumors have unacceptable magnitude of motion for PBS proton therapy. Therefore it is important to analyze the motion and understand the significance of the interplay effect for each patient. The factors that affect interplay effect and its washout include magnitude of motion, spot size, spot scanning sequence and speed. Selection of beam angle, scanning direction, repainting and fractionation can all reduce the interplay effect. An overview of respiratory motion management in PBS proton therapy including assessment of tumor motion and WET evaluation will be first presented. As thoracic tumors have very different motion patterns from liver tumors, examples would be provided for both anatomic sites. As thoracic tumors are typically located within highly heterogeneous environments, dose calculation accuracy is a concern for both treatment target and surrounding organs such as spinal cord or esophagus. Strategies for mitigating the interplay effect in PBS will be presented and the pros and cons of various motion mitigation strategies will be discussed. Learning Objectives: Motion analysis for individual patients with respect to interplay effect Interplay effect and mitigation strategies for treating thoracic/liver tumors with PBS Treatment planning margins for PBS The impact of proton dose calculation engines over heterogeneous treatment target and surrounding organs I have a current research funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian; L. Lin, I have a current funding from Varian Medical System under the master agreement between University of Pennsylvania and

  16. WE-E-BRB-01: Personalized Motion Management Strategies for Pencil Beam Scanning Proton Therapy

    International Nuclear Information System (INIS)

    Zhu, X.

    2016-01-01

    Strategies for treating thoracic and liver tumors using pencil beam scanning proton therapy Thoracic and liver tumors have not been treated with pencil beam scanning (PBS) proton therapy until recently. This is because of concerns about the significant interplay effects between proton spot scanning and patient’s respiratory motion. However, not all tumors have unacceptable magnitude of motion for PBS proton therapy. Therefore it is important to analyze the motion and understand the significance of the interplay effect for each patient. The factors that affect interplay effect and its washout include magnitude of motion, spot size, spot scanning sequence and speed. Selection of beam angle, scanning direction, repainting and fractionation can all reduce the interplay effect. An overview of respiratory motion management in PBS proton therapy including assessment of tumor motion and WET evaluation will be first presented. As thoracic tumors have very different motion patterns from liver tumors, examples would be provided for both anatomic sites. As thoracic tumors are typically located within highly heterogeneous environments, dose calculation accuracy is a concern for both treatment target and surrounding organs such as spinal cord or esophagus. Strategies for mitigating the interplay effect in PBS will be presented and the pros and cons of various motion mitigation strategies will be discussed. Learning Objectives: Motion analysis for individual patients with respect to interplay effect Interplay effect and mitigation strategies for treating thoracic/liver tumors with PBS Treatment planning margins for PBS The impact of proton dose calculation engines over heterogeneous treatment target and surrounding organs I have a current research funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian; L. Lin, I have a current funding from Varian Medical System under the master agreement between University of Pennsylvania and

  17. Experimental determination of beam quality factors, kQ, for two types of Farmer chamber in a 10 MV photon and a 175 MeV proton beam.

    Science.gov (United States)

    Medin, Joakim; Ross, Carl K; Klassen, Norman V; Palmans, Hugo; Grusell, Erik; Grindborg, Jan-Erik

    2006-03-21

    Absorbed doses determined with a sealed water calorimeter operated at 4 degrees C are compared with the results obtained using ionization chambers and the IAEA TRS-398 code of practice in a 10 MV photon beam (TPR(20,10) = 0.734) and a 175 MeV proton beam (at a depth corresponding to the residual range, R(res) = 14.7 cm). Three NE 2571 and two FC65-G ionization chambers were calibrated in terms of absorbed-dose-to-water in (60)Co at the Swedish secondary standard dosimetry laboratory, directly traceable to the BIPM. In the photon beam quality, calorimetry was found to agree with ionometry within 0.3%, confirming the k(Q) values tabulated in TRS-398. In contrast, a 1.8% deviation was found in the proton beam at 6 g cm(-2) depth, suggesting that the TRS-398 tabulated k(Q) values for these two ionization chamber types are too high. Assuming no perturbation effect in the proton beam for the ionization chambers, a value for (w(air)/e)(Q) of 33.6 J C(-1) +/- 1.7% (k = 1) can be derived from these measurements. An analytical evaluation of the effect from non-elastic nuclear interactions in the ionization chamber wall indicates a perturbation effect of 0.6%. Including this estimated result in the proton beam would increase the determined (w(air)/e)(Q) value by the same amount.

  18. Measurements on a Gabor lens for neutralizing and focusing a 30 keV proton beam

    International Nuclear Information System (INIS)

    Palkovic, J.A.; Hren, R.; Lee, G.; Mills, F.E.; Schmidt, C.W.; Wendt, J.; Young, D.E.

    1989-01-01

    The authors have reported previously on the use of a Gabor lens (also referred to as a plasma or space charge lens) to focus and neutralize a low energy proton beam. A different lens geometry and a higher anode voltage have been adopted to overcome a lack of stability present in the previous design. They report on studies in progress to measure the focusing properties of the Gabor lens and determine whether it can be used to match a 30 keV proton beam into radio frequency quadrupole (RFQ) Accelerator. 10 refs., 4 figs

  19. Proton Fast Ignition

    International Nuclear Information System (INIS)

    Key, M H; Freeman, R R; Hatchett, S P; MacKinnon, A J; Patel, P K; Snavely, R A; Stephens, R B

    2006-04-01

    Fast ignition (FI) by a laser generated ballistically focused proton beam is a more recently proposed alternative to the original concept of FI by a laser generated beam of relativistic electrons. It has potential advantages in less complex energy transport into dense plasma. Recent successful target heating experiments motivate further investigation of the feasibility of proton fast ignition. The concept, the physics and characteristics of the proton beams, the recent experimental work on focusing of the beams and heating of solid targets and the overall prospects for proton FI are discussed

  20. Measurements of lateral penumbra for uniform scanning proton beams under various beam delivery conditions and comparison to the XiO treatment planning system

    International Nuclear Information System (INIS)

    Rana, Suresh; Zeidan, Omar; Ramirez, Eric; Rains, Michael; Gao, Junfang; Zheng, Yuanshui

    2013-01-01

    Purpose: The main purposes of this study were to (1) investigate the dependency of lateral penumbra (80%–20% distance) of uniform scanning proton beams on various factors such as air gap, proton range, modulation width, compensator thickness, and depth, and (2) compare the lateral penumbra calculated by a treatment planning system (TPS) with measurements.Methods: First, lateral penumbra was measured using solid–water phantom and radiographic films for (a) air gap, ranged from 0 to 35 cm, (b) proton range, ranged from 8 to 30 cm, (c) modulation, ranged from 2 to 10 cm, (d) compensator thickness, ranged from 0 to 20 cm, and (e) depth, ranged from 7 to 15 cm. Second, dose calculations were computed in a virtual water phantom using the XiO TPS with pencil beam algorithm for identical beam conditions and geometrical configurations that were used for the measurements. The calculated lateral penumbra was then compared with the measured one for both the horizontal and vertical scanning magnets of our uniform scanning proton beam delivery system.Results: The results in the current study showed that the lateral penumbra of horizontal scanning magnet was larger (up to 1.4 mm for measurement and up to 1.0 mm for TPS) compared to that of vertical scanning magnet. Both the TPS and measurements showed an almost linear increase in lateral penumbra with increasing air gap as it produced the greatest effect on lateral penumbra. Lateral penumbra was dependent on the depth and proton range. Specifically, the width of lateral penumbra was found to be always lower at shallower depth than at deeper depth within the spread out Bragg peak (SOBP) region. The lateral penumbra results were less sensitive to the variation in the thickness of compensator, whereas lateral penumbra was independent of modulation. Overall, the comparison between the results of TPS with that of measurements indicates a good agreement for lateral penumbra, with TPS predicting higher values compared to

  1. SU-E-T-146: Reference Dosimetry for Protons and Light-Ion Beams Based on Graphite Calorimetry.

    Science.gov (United States)

    Rossomme, S; Palmans, H; Thomas, R; Lee, N; Bailey, M; Shipley, D; Al-Sulaiti, L; Cirrone, P; Romano, F; Kacperek, A; Bertrand, D; Vynckier, S

    2012-06-01

    The IAEA TRS-398 code of practice can be applied for the measurement of absorbed dose to water under reference conditions with an ionization chamber. For protons, the combined relative standard uncertainty on those measurements is less than 2% while for light-ion beams, it is considerably larger, i.e. 3.2%, mainly due to the higher uncertainty contributions for the water to air stopping power ration and the W air-value on the beam quality correction factors kQ,Q 0 . To decrease this uncertainty, a quantification of kQ,Q 0 is proposed using a primary standard level graphite calorimeter. This work includes numerical and experimental determinations of dose conversion factors to derive dose to water from graphite calorimetry. It also reports on the first experimental data obtained with the graphite calorimeter in proton, alpha and carbon ion beams. Firstly, the dose conversion has been calculated with by Geant4 Monte-Carlo simulations through the determination of the water to graphite stopping power ratio and the fluence correction factor. The latter factor was also derived by comparison of measured ionization curves in graphite and water. Secondly, kQ,Q 0 was obtained by comparison of the dose response of ionization chambers with that of the calorimeter. Stopping power ratios are found to vary by no more than 0.35% up to the Bragg peak, while fluence correction factors are shown to increase slightly above unity close to the Bragg peak. The comparison of the calorimeter with ionization chambers is currently under analysis. For the modulated proton beam, preliminary results on W air confirm the value recommended in TRS-398. Data in both the non-modulated proton and light-ion beams indicate higher values but further investigation of heat loss corrections is needed. The application of graphite calorimetry to proton, alpha and carbon ion beams has been demonstrated successfully. Other experimental campaigns will be held in 2012. This work is supported by the BioWin program

  2. A 62-MeV Proton Beam for the Treatment of Ocular Melanoma at Laboratori Nazionali del Sud-INFN

    Science.gov (United States)

    Cirrone, G. A. P.; Cuttone, G.; Lojacono, P. A.; Lo Nigro, S.; Mongelli, V.; Patti, I. V.; Privitera, G.; Raffaele, L.; Rifuggiato, D.; Sabini, M. G.; Salamone, V.; Spatola, C.; Valastro, L. M.

    2004-06-01

    At the Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali del Sud (INFN-LNS) in Catania, Italy, the first Italian protontherapy facility, named Centro di AdroTerapia e Applicazioni Nucleari Avanzate (CATANA) has been built in collaboration with the University of Catania. It is based on the use of the 62-MeV proton beam delivered by the K=800 Superconducting Cyclotron installed and working at INFN-LNS since 1995. The facility is mainly devoted to the treatment of ocular diseases like uveal melanoma. A beam treatment line in air has been assembled together with a dedicated positioning patient system. The facility has been in operation since the beginning of 2002 and 66 patients have been successfully treated up to now. The main features of CATANA together with the clinical and dosimetric features will be extensively described; particularly, the proton beam line, that has been entirely built at LNS, with all its elements, the experimental transversal and depth dose distributions of the 62-MeV proton beam obtained for a final collimator of 25-mm diameter and the experimental depth dose distributions of a modulated proton beam obtained for the same final collimator. Finally, the clinical results over 1 yr of treatments, describing the features of the treated diseases will be reported.

  3. Early experience of proton beam therapy combined with chemotherapy for locally advanced oropharyngeal cancer

    International Nuclear Information System (INIS)

    Ishikawa, Youjirou; Nakamura, Tatsuya; Takada, Akinori; Takayama, Kanako; Makita, Chiyoko; Suzuki, Motohisa; Azami, Yusuke; Kikuchi, Yasuhiro; Fuwa, Nobukazu

    2013-01-01

    Between 2009 and 2012, 10 patients with advanced oropharyngeal cancer underwent proton therapy combined with chemotherapy. The initial results of this therapy were 8 complete response (CR) and 2 partial response (PR), local recurrence was detected 1 patient. Proton beam therapy combined with chemotherapy is thought to be an effective treatment for locally advanced oropharyngeal cancer. (author)

  4. Effect of analytical proton beam irradiation on lead-white pigments, characterized by EPR spectroscopy

    Science.gov (United States)

    Gourier, Didier; Binet, Laurent; Gonzalez, Victor; Vezin, Hervé; Touati, Nadia; Calligaro, Thomas

    2018-01-01

    Analytical techniques using proton beams with energy in the MeV range are commonly used to study archeological artefact and artistic objects. However ion beams can induce alteration of fragile materials, which is notably the case of easel paintings, limiting the use of these techniques. We used continuous wave EPR and pulse EPR spectroscopy to reveal the effect of 3 MeV proton irradiation on lead carbonates, which were extensively employed as white pigments from the antiquity to the 20th century. Two kinds of paramagnetic centers were identified in cerussite (PbCO3): the first one is CO3- radicals formed by hole trapping by CO32- ions, and the second one is NO32- radical resulting from electron trapping by NO3- impurities. Hydrocerussite (2PbCO3·Pb(OH)2) is the most darkened material under proton beam, however it exhibits no NO32- radicals and 20 times less CO3- radicals than cerussite. Consequently these paramagnetic centers are not directly responsible for the darkening of lead-white pigments. We proposed that their higher instability in hydrocerussite might be at the origin of the formation of color centers in this material.

  5. Improvements of PKU PMECRIS for continuous hundred hours CW proton beam operation

    International Nuclear Information System (INIS)

    Peng, S. X.; Ren, H. T.; Zhang, T.; Zhang, J. F.; Xu, Y.; Guo, Z. Y.; Zhang, A. L.; Chen, J. E.

    2016-01-01

    In order to improve the source stability, a long term continuous wave (CW) proton beam experiment has been carried out with Peking University compact permanent magnet 2.45 GHz ECR ion source (PKU PMECRIS). Before such an experiment a lot of improvements and modifications were completed on the source body, the Faraday cup and the PKU ion source test bench. At the beginning of 2015, a continuous operation of PKU PMECRIS for 306 h with more than 50 mA CW beam was carried out after success of many short term tests. No plasma generator failure or high voltage breakdown was observed during that running period and the proton source reliability is near 100%. Total beam availability, which is defined as 35-keV beam-on time divided by elapsed time, was higher than 99% [S. X. Peng et al., Chin. Phys. B 24(7), 075203 (2015)]. A re-inspection was performed after another additional 100 h operation (counting time) and no obvious sign of component failure was observed. Counting the previous source testing time together, this PMECRs longevity is now demonstrated to be greater than 460 h. This paper is mainly concentrated on the improvements for this long term experiment

  6. Improvements of PKU PMECRIS for continuous hundred hours CW proton beam operation

    Science.gov (United States)

    Peng, S. X.; Zhang, A. L.; Ren, H. T.; Zhang, T.; Zhang, J. F.; Xu, Y.; Guo, Z. Y.; Chen, J. E.

    2016-02-01

    In order to improve the source stability, a long term continuous wave (CW) proton beam experiment has been carried out with Peking University compact permanent magnet 2.45 GHz ECR ion source (PKU PMECRIS). Before such an experiment a lot of improvements and modifications were completed on the source body, the Faraday cup and the PKU ion source test bench. At the beginning of 2015, a continuous operation of PKU PMECRIS for 306 h with more than 50 mA CW beam was carried out after success of many short term tests. No plasma generator failure or high voltage breakdown was observed during that running period and the proton source reliability is near 100%. Total beam availability, which is defined as 35-keV beam-on time divided by elapsed time, was higher than 99% [S. X. Peng et al., Chin. Phys. B 24(7), 075203 (2015)]. A re-inspection was performed after another additional 100 h operation (counting time) and no obvious sign of component failure was observed. Counting the previous source testing time together, this PMECRs longevity is now demonstrated to be greater than 460 h. This paper is mainly concentrated on the improvements for this long term experiment.

  7. Improvements of PKU PMECRIS for continuous hundred hours CW proton beam operation

    Energy Technology Data Exchange (ETDEWEB)

    Peng, S. X., E-mail: sxpeng@pku.edu.cn; Ren, H. T.; Zhang, T.; Zhang, J. F.; Xu, Y.; Guo, Z. Y. [State Key Laboratory of Nuclear Physics and Technology and Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing 100871 (China); Zhang, A. L.; Chen, J. E. [State Key Laboratory of Nuclear Physics and Technology and Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing 100871 (China); University of Chinese Academy of Sciences, Beijing 100049 (China)

    2016-02-15

    In order to improve the source stability, a long term continuous wave (CW) proton beam experiment has been carried out with Peking University compact permanent magnet 2.45 GHz ECR ion source (PKU PMECRIS). Before such an experiment a lot of improvements and modifications were completed on the source body, the Faraday cup and the PKU ion source test bench. At the beginning of 2015, a continuous operation of PKU PMECRIS for 306 h with more than 50 mA CW beam was carried out after success of many short term tests. No plasma generator failure or high voltage breakdown was observed during that running period and the proton source reliability is near 100%. Total beam availability, which is defined as 35-keV beam-on time divided by elapsed time, was higher than 99% [S. X. Peng et al., Chin. Phys. B 24(7), 075203 (2015)]. A re-inspection was performed after another additional 100 h operation (counting time) and no obvious sign of component failure was observed. Counting the previous source testing time together, this PMECRs longevity is now demonstrated to be greater than 460 h. This paper is mainly concentrated on the improvements for this long term experiment.

  8. Proton and heavy ion beam (charged particle therapy)

    International Nuclear Information System (INIS)

    Kanai, Tatsuaki

    2003-01-01

    There are distinguished therapeutic irradiation facilities of proton and heavy ion beam in Japan. The beam, due to its physical properties, is advantageous for focusing on the lesion in the body and for reducing the exposure dose to normal tissues, relative to X-ray. This makes it possible to irradiate the target lesion with the higher dose. The present review describes physical properties of the beam, equipments for the therapeutic irradiation, the respiratory-gated irradiation system, the layer-stacking irradiation system, therapy planning, and future prospect of the therapy. More than 1,400 patients have received the therapy in National Institute of Radiological Sciences (NIRS) and given a good clinical outcome. The targets are cancers of the head and neck, lung, liver, uterine and prostate, and osteosarcoma. The therapy of osteosarcoma is particularly important, which bringing about the high cure rate. Severe adverse effects are not seen with exception for the digestive tract ulcer. Many attempts like the respiratory-gated and layer-stacking systems and to shorten the therapy period to within 1 week are in progress. (N.I.)

  9. Memory testing with Saturne synchrotron beams. Experiments with protons and deuterons

    International Nuclear Information System (INIS)

    Buisson, J.

    1989-01-01

    For simulate light ions of the cosmic rays CEA will use facilities used in fundamental physic research. SATURNE is a synchrotron especially designed to accelerate light particles, for example protons with energy up to 2.9 GeV. Two experiments are made on SATURNE to specify the beam characteristics (energy and intensity) and to adapt the beam for irradiation of electronic components. During these preliminary experimentation memories and microprocessors was tested. The results of the tests (cross-section) are given in this paper [fr

  10. High yield of low-energy pions from a high-energy primary proton beam

    International Nuclear Information System (INIS)

    Bertin, A.; Capponi, S.; De Castro, S.

    1987-01-01

    This paper presents the results of the first measurement on the yield of pions with momentum smaller than 220 MeV/c, produced by a 300 GeV/c proton beam. The measurements, performed at the CERN super proton synchrotron using tungsten production targets of different lengths, are discussed referring to the possibility of extending to high-energy laboratories the access to fundamental research involving low-energy pions and muons

  11. High current, high energy proton beams accelerated by a sub-nanosecond laser

    Czech Academy of Sciences Publication Activity Database

    Margarone, Daniele; Krása, Josef; Picciotto, A.; Torrisi, L.; Láska, Leoš; Velyhan, Andriy; Prokůpek, Jan; Ryc, L.; Parys, P.; Ullschmied, Jiří; Rus, Bedřich

    2011-01-01

    Roč. 653, č. 1 (2011), s. 159-163 ISSN 0168-9002 R&D Projects: GA ČR(CZ) GAP205/11/1165; GA AV ČR IAA100100715; GA MŠk(CZ) 7E09092 EU Projects: European Commission(XE) 212105 - ELI-PP Institutional research plan: CEZ:AV0Z10100523; CEZ:AV0Z20430508 Keywords : laser-acceleration * proton beam * high ion current * time -of-flight * proton energy distribution Subject RIV: BH - Optics, Masers, Lasers Impact factor: 1.207, year: 2011

  12. Unbunched beam electron-proton instability in the PSR and advanced hadron facilities

    International Nuclear Information System (INIS)

    Wang, Tai-Sen; Pisent, A.; Neuffer, D.V.

    1989-01-01

    We studied the possibility of the occurrence of transverse instability induced by trapped electrons in unbunched beams in the Proton Storage Ring and the proposed Advance Hadron Facility (AHF) at Los Alamos, as well as in the proposed Kaon Factory at TRIUMF. We found that the e-p instability may be possible for unbunched beams in the PSR but is unlikely to occur in the advanced hadron facilities. 8 refs., 4 figs

  13. Prototype Digital Beam Position and Phase Monitor for the 100-MeV Proton Linac of PEFP

    CERN Document Server

    Yu In Ha; Kim, Sung-Chul; Park, In-Soo; Park, Sung-Ju; Tae Kim, Do

    2005-01-01

    The PEFP (Proton Engineering Frontier Project) at the KAERI (Korea Atomic Energy Research Institute) is building a high-power proton linear accelerator aiming to generate 100-MeV proton beams with 20-mA peak current (pulse width and max. repetition rate of 1 ms and 120 Hz respectively). We are developing a prototype digital BPPM (Beam Position and Phase Monitor) for the PEFP linac utilizing the digital technology with field programmable gate array (FPGA). The RF input signals are down converted to 10 MHz and sampled at 40 MHz with 14-bit ADC to produce I and Q data streams. The system is designed to provide a position and phase resolution of 0.1% and 0.1? RMS respectively. The fast digital processing is networked to the EPICS-based control system with an embedded processor (Blackfin). In this paper, the detailed description of the prototype digital beam position and phase monitor will be described with the performance test results.

  14. MO-FG-CAMPUS-JeP1-03: Luminescence Imaging of Water During Proton Beam Irradiation for Range Estimation

    International Nuclear Information System (INIS)

    Yamamoto, S; Komori, M; Toshito, T; Watabe, H

    2016-01-01

    Purpose: Since proton therapy has the ability to selectively deliver a dose to a target tumor, the dose distribution should be accurately measured. A precise and efficient method to evaluate the dose distribution is desired. We found that luminescence was emitted from water during proton irradiation and thought this phenomenon could be used for estimating the dose distribution. Methods: For this purpose, we placed water phantoms set on a table with a spot-scanning proton-therapy system, and luminescence images of these phantoms were measured with a high-sensitivity cooled charge coupled device (CCD) camera during proton-beam irradiation. We also conducted the imaging of phantoms of pure-water, fluorescein solution and acrylic block. We made three dimensional images from the projection data. Results: The luminescence images of water phantoms during the proton-beam irradiations showed clear Bragg peaks, and the measured proton ranges from the images were almost the same as those obtained with an ionization chamber. The image of the pure-water phantom also showed almost the same distribution as the tap-water phantom, indicating that the luminescence image was not related to impurities in the water. The luminescence image of fluorescein solution had ∼3 times higher intensity than water, with the same proton range as that of water. The luminescence image of the acrylic phantom had 14.5% shorter proton range than that of water; the proton range in the acrylic phantom was relatively matched with the calculated value. The luminescence images of the tap-water phantom during proton irradiation could be obtained in less than 2 sec. Three dimensional images were successfully obtained which have more quantitative information. Conclusion: Luminescence imaging during proton-beam irradiation has the potential to be a new method for range estimations in proton therapy.

  15. MO-FG-CAMPUS-JeP1-03: Luminescence Imaging of Water During Proton Beam Irradiation for Range Estimation

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, S; Komori, M [Nagoya University, Nagoya, Aichi (Japan); Toshito, T [Nagoya Proton Therapy Center, Nagoya, Aichi (Japan); Watabe, H [Tohoku University, Sendai, Miyagi (Japan)

    2016-06-15

    Purpose: Since proton therapy has the ability to selectively deliver a dose to a target tumor, the dose distribution should be accurately measured. A precise and efficient method to evaluate the dose distribution is desired. We found that luminescence was emitted from water during proton irradiation and thought this phenomenon could be used for estimating the dose distribution. Methods: For this purpose, we placed water phantoms set on a table with a spot-scanning proton-therapy system, and luminescence images of these phantoms were measured with a high-sensitivity cooled charge coupled device (CCD) camera during proton-beam irradiation. We also conducted the imaging of phantoms of pure-water, fluorescein solution and acrylic block. We made three dimensional images from the projection data. Results: The luminescence images of water phantoms during the proton-beam irradiations showed clear Bragg peaks, and the measured proton ranges from the images were almost the same as those obtained with an ionization chamber. The image of the pure-water phantom also showed almost the same distribution as the tap-water phantom, indicating that the luminescence image was not related to impurities in the water. The luminescence image of fluorescein solution had ∼3 times higher intensity than water, with the same proton range as that of water. The luminescence image of the acrylic phantom had 14.5% shorter proton range than that of water; the proton range in the acrylic phantom was relatively matched with the calculated value. The luminescence images of the tap-water phantom during proton irradiation could be obtained in less than 2 sec. Three dimensional images were successfully obtained which have more quantitative information. Conclusion: Luminescence imaging during proton-beam irradiation has the potential to be a new method for range estimations in proton therapy.

  16. Analytical linear energy transfer model including secondary particles: calculations along the central axis of the proton pencil beam

    International Nuclear Information System (INIS)

    Marsolat, F; De Marzi, L; Mazal, A; Pouzoulet, F

    2016-01-01

    In proton therapy, the relative biological effectiveness (RBE) depends on various types of parameters such as linear energy transfer (LET). An analytical model for LET calculation exists (Wilkens’ model), but secondary particles are not included in this model. In the present study, we propose a correction factor, L sec , for Wilkens’ model in order to take into account the LET contributions of certain secondary particles. This study includes secondary protons and deuterons, since the effects of these two types of particles can be described by the same RBE-LET relationship. L sec was evaluated by Monte Carlo (MC) simulations using the GATE/GEANT4 platform and was defined by the ratio of the LET d distributions of all protons and deuterons and only primary protons. This method was applied to the innovative Pencil Beam Scanning (PBS) delivery systems and L sec was evaluated along the beam axis. This correction factor indicates the high contribution of secondary particles in the entrance region, with L sec values higher than 1.6 for a 220 MeV clinical pencil beam. MC simulations showed the impact of pencil beam parameters, such as mean initial energy, spot size, and depth in water, on L sec . The variation of L sec with these different parameters was integrated in a polynomial function of the L sec factor in order to obtain a model universally applicable to all PBS delivery systems. The validity of this correction factor applied to Wilkens’ model was verified along the beam axis of various pencil beams in comparison with MC simulations. A good agreement was obtained between the corrected analytical model and the MC calculations, with mean-LET deviations along the beam axis less than 0.05 keV μm −1 . These results demonstrate the efficacy of our new correction of the existing LET model in order to take into account secondary protons and deuterons along the pencil beam axis. (paper)

  17. Spatial and temporal beam profile monitor with nanosecond resolution for CERN's Linac4 and Superconducting Proton Linac

    CERN Document Server

    Hori, M

    2008-01-01

    The Linac4, now being developed at CERN, will provide 160-MeV H- beams of high intensity . Before this beam can be injected into the CERN Proton Synchrotron Booster or future Superconducting Proton Linac for further acceleration, some sequences of 500-ps-long micro-bunches must be removed from it, using a beam chopper. These bunches, if left in the beam, would fall outside the longitudinal acceptance of the accelerators and make them radioactive. We developed a monitor to measure the time structure and spatial profile of this chopped beam, with respective resolutions and . Its large active area and dynamic range also allows investigations of beam halos. The ion beam first struck a carbon foil, and secondary electrons emerging from the foil were accelerated by a series of parallel grid electrodes. These electrons struck a phosphor screen, and the resulting image of the scintillation light was guided to a thermoelectrically cooled, charge-coupled device camera. The time resolution was attained by applying high-...

  18. A Monte Carlo pencil beam scanning model for proton treatment plan simulation using GATE/GEANT4

    Energy Technology Data Exchange (ETDEWEB)

    Grevillot, L; Freud, N; Sarrut, D [Universite de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Universite Lyon 1, Centre Leon Berard, Lyon (France); Bertrand, D; Dessy, F, E-mail: loic.grevillot@creatis.insa-lyon.fr [IBA, B-1348, Louvain-la Neuve (Belgium)

    2011-08-21

    This work proposes a generic method for modeling scanned ion beam delivery systems, without simulation of the treatment nozzle and based exclusively on beam data library (BDL) measurements required for treatment planning systems (TPS). To this aim, new tools dedicated to treatment plan simulation were implemented in the Gate Monte Carlo platform. The method was applied to a dedicated nozzle from IBA for proton pencil beam scanning delivery. Optical and energy parameters of the system were modeled using a set of proton depth-dose profiles and spot sizes measured at 27 therapeutic energies. For further validation of the beam model, specific 2D and 3D plans were produced and then measured with appropriate dosimetric tools. Dose contributions from secondary particles produced by nuclear interactions were also investigated using field size factor experiments. Pristine Bragg peaks were reproduced with 0.7 mm range and 0.2 mm spot size accuracy. A 32 cm range spread-out Bragg peak with 10 cm modulation was reproduced with 0.8 mm range accuracy and a maximum point-to-point dose difference of less than 2%. A 2D test pattern consisting of a combination of homogeneous and high-gradient dose regions passed a 2%/2 mm gamma index comparison for 97% of the points. In conclusion, the generic modeling method proposed for scanned ion beam delivery systems was applicable to an IBA proton therapy system. The key advantage of the method is that it only requires BDL measurements of the system. The validation tests performed so far demonstrated that the beam model achieves clinical performance, paving the way for further studies toward TPS benchmarking. The method involves new sources that are available in the new Gate release V6.1 and could be further applied to other particle therapy systems delivering protons or other types of ions like carbon.

  19. Spin flipping a stored polarized proton beam at the IUCF cooler ring

    International Nuclear Information System (INIS)

    Phelps, R.A.

    1995-01-01

    We recently studied the spin flip of a vertically polarized 139 MeV proton beam stored in the IUCF Cooler Ring. We used an rf solenoid to induce a depolarizing resonance in the ring; we flipped the spin by varying the solenoid field's frequency through this resonance. We found a polarization loss after multiple spin flips less than 0.1% per flip; we also found that this loss increased for very slow frequency changes. This spin flip could reduce systematic errors in stored polarization beam experiments by allowing frequent beam polarization reversals during the experiment. copyright 1995 American Institute of Physics

  20. A proposal of a beam injection device for the proton storage ring of JAERI neutron science project

    International Nuclear Information System (INIS)

    Suzuki, Yasuo

    1998-01-01

    A new injection device (a charge-exchange device) with light and magnetic field, is proposed for a proton storage ring of JAERI Neutron Science Project. This injection device is composed of a neutralizer and an ionizer. The neutralizer strips electrons of H 0 beam into H - one with the undulator magnetic field. The ionizer which is composed of undulator magnets and an optical resonator placed along a straight part in the storage ring, can ionize effectively the H 0 beam excited to n=3 level by a laser beam into H + one. Adopting the 2nd harmonics of Nd : YAG laser, the powerful laser on the market can be used, and the required items of the technological development can be minimized. The energy of the particle beam, however, should be accelerated up to 1.587 GeV by 6% increase from 1.5 GeV. In this device, the non-charge-exchange rate and beam-spill can be minimized by decreasing the deflection angle of the beam which occurs at the charge-exchange process. This method can be realized with exiting technologies and there are not any effects on the trajectory of the ring-circulating proton beam due to scatterings by the foil as the usual charge-exchange devices. This device, therefore, will be an optimal and highly effective method of the least beam-spill as the injector of the high power proton storage ring. (author)

  1. A case of acute exacerbation of idiopathic pulmonary fibrosis after proton beam therapy for non-small cell lung cancer

    International Nuclear Information System (INIS)

    Nagano, Tatsuya; Kotani, Yoshikazu; Fujii, Osamu

    2012-01-01

    There have been no reports describing acute exacerbations of idiopathic pulmonary fibrosis after particle radiotherapy for non-small cell lung cancer. The present study describes the case of a 76-year-old Japanese man with squamous cell carcinoma of the lung that relapsed in the left upper lobe 1 year after right upper lobectomy. He had been treated with oral prednisolone 20 mg/day every 2 days for idiopathic pulmonary fibrosis, and the relapsed lung cancer was treated by proton beam therapy, which was expected to cause the least adverse effects on the idiopathic pulmonary fibrosis. Fifteen days after the initiation of proton beam therapy, the idiopathic pulmonary fibrosis exacerbated, centered on the left upper lobe, for which intensive steroid therapy was given. About 3 months later, the acute exacerbation of idiopathic pulmonary fibrosis had improved, and the relapsed lung cancer became undetectable. Clinicians should be aware that an acute exacerbation of idiopathic pulmonary fibrosis may occur even in proton beam therapy, although proton beam therapy appears to be an effective treatment option for patients with idiopathic pulmonary fibrosis. (author)

  2. Investigation of the effects of high-energy proton-beam irradiation on metal-oxide surfaces by using methane adsorption isotherms

    International Nuclear Information System (INIS)

    Kim, Euikwoun; Lee, Junggil; Kim, Jaeyong; Kim, Kyeryung

    2012-01-01

    The creation of possible local defects on metal-oxide surfaces due to irradiation with a high-energy proton beam was investigated by using a series of gas adsorption isotherms for methane (CH 4 ) on a MgO powder surface. After a MgO powder surface having only a (100) surface had been irradiated with a 35-MeV proton beam, the second atomic layer of methane had completely disappeared while two distinct atomic layers were found in a layer-by-layer fashion on the surfaces of unirradiated samples. This subtle modification of the surface is evidenced by a change of the contrasts in the morphologies measured a using a transmission electron microscopy. Combined results obtained from an electron microscopy and methane adsorption isotherms strongly suggest that the high-energy proton-beam irradiation induced a local surface modification by imparting kinetic energy to the sample. The calculation of the 2-dimensional compressibility values, which are responsible for the formation of the atomic layers, confirmed the surface modification after irradiating surface-clean MgO powders with a proton beam.

  3. Ultrafast Melting of Carbon Induced by Intense Proton Beams

    International Nuclear Information System (INIS)

    Pelka, A.; Guenther, M. M.; Harres, K.; Otten, A.; Roth, M.; Gregori, G.; Gericke, D. O.; Vorberger, J.; Glenzer, S. H.; Kritcher, A. L.; Heathcote, R.; Li, B.; Neely, D.; Kugland, N. L.; Niemann, C.; Makita, M.; Riley, D.; Mithen, J.; Schaumann, G.; Schollmeier, M.

    2010-01-01

    Laser-produced proton beams have been used to achieve ultrafast volumetric heating of carbon samples at solid density. The isochoric melting of carbon was probed by a scattering of x rays from a secondary laser-produced plasma. From the scattering signal, we have deduced the fraction of the material that was melted by the inhomogeneous heating. The results are compared to different theoretical approaches for the equation of state which suggests modifications from standard models.

  4. Effectiveness of proton-beam irradiation of the pituitary gland in children with Itsenko-Cushing disease

    International Nuclear Information System (INIS)

    Zhukovskij, M.A.; Bukhman, A.I.; Levshina, R.B.; Kirpatovskaya, L.E.; Kolesnikova, G.S.; Pankova, S.S.; Lisovets, S.P.; Gosudarstvennyj Komitet po Ispol'zovaniyu Atomnoj Ehnergii SSSR, Moscow

    1990-01-01

    The results of the treatment of 20 children with Icenko-Cushing disease (ICD) by proton-beam irradiation of the pituitary glandare presented. The use of the medical proton beam of the Institute of Theoretical and Experimental Physics found to be effective for the treatment of children with mild and average forms of ICD. Irradiation of the pituitary gland at a dose of 70-100 Gy is accompanied by general and local radiation reactions which are not dangerous for children. The time of development of remission after irradiation depends on a degree of severity and features of a course of disease

  5. Dose perturbation effect of metallic spinal implants in proton beam therapy.

    Science.gov (United States)

    Jia, Yingcui; Zhao, Li; Cheng, Chee-Wai; McDonald, Mark W; Das, Indra J

    2015-09-08

    The purpose of this study was to investigate the effect of dose perturbations for two metallic spinal screw implants in proton beam therapy in the perpendicular and parallel beam geometry. A 5.5 mm (diameter) by 45 mm (length) stainless steel (SS) screw and a 5.5 mm by 35 mm titanium (Ti) screw commonly used for spinal fixation were CT-scanned in a hybrid phantom of water and solid water. The CT data were processed with an orthopedic metal artifact reduction (O-MAR) algorithm. Treatment plans were generated for each metal screw with a proton beam oriented, first parallel and then perpendicular, to the longitudinal axis of the screw. The calculated dose profiles were compared with measured results from a plane-parallel ion chamber and Gafchromic EBT2 films. For the perpendicular setup, the measured dose immediately downstream from the screw exhibited dose enhancement up to 12% for SS and 8% for Ti, respectively, but such dose perturbation was not observed outside the lateral edges of the screws. The TPS showed 5% and 2% dose reductions immediately at the interface for the SS nd Ti screws, respectively, and up to 9% dose enhancements within 1 cm outside of the lateral edges of the screws. The measured dose enhancement was only observed within 5 mm from the interface along the beam path. At deeper depths, the lateral dose profiles appeared to be similar between the measurement and TPS, with dose reduction in the screw shadow region and dose enhancement within 1-2 cm outside of the lateral edges of the metals. For the parallel setup, no significant dose perturbation was detected at lateral distance beyond 3 mm away from both screws. Significant dose discrepancies exist between TPS calculations and ion chamber and film measurements in close proximity of high-Z inhomogeneities. The observed dose enhancement effect with proton therapy is not correctly modeled by TPS. An extra measure of caution should be taken when evaluating dosimetry with spinal metallic implants.

  6. Analysis of 440 GeV proton beam-matter interaction experiments at the High Radiation Materials test facility at CERN

    Science.gov (United States)

    Burkart, F.; Schmidt, R.; Raginel, V.; Wollmann, D.; Tahir, N. A.; Shutov, A.; Piriz, A. R.

    2015-08-01

    In a previous paper [Schmidt et al., Phys. Plasmas 21, 080701 (2014)], we presented the first results on beam-matter interaction experiments that were carried out at the High Radiation Materials test facility at CERN. In these experiments, extended cylindrical targets of solid copper were irradiated with beam of 440 GeV protons delivered by the Super Proton Synchrotron (SPS). The beam comprised of a large number of high intensity proton bunches, each bunch having a length of 0.5 ns with a 50 ns gap between two neighboring bunches, while the length of this entire bunch train was about 7 μs. These experiments established the existence of the hydrodynamic tunneling phenomenon the first time. Detailed numerical simulations of these experiments were also carried out which were reported in detail in another paper [Tahir et al., Phys. Rev. E 90, 063112 (2014)]. Excellent agreement was found between the experimental measurements and the simulation results that validate our previous simulations done using the Large Hadron Collider (LHC) beam of 7 TeV protons [Tahir et al., Phys. Rev. Spec. Top.--Accel. Beams 15, 051003 (2012)]. According to these simulations, the range of the full LHC proton beam and the hadronic shower can be increased by more than an order of magnitude due to the hydrodynamic tunneling, compared to that of a single proton. This effect is of considerable importance for the design of machine protection system for hadron accelerators such as SPS, LHC, and Future Circular Collider. Recently, using metal cutting technology, the targets used in these experiments have been dissected into finer pieces for visual and microscopic inspection in order to establish the precise penetration depth of the protons and the corresponding hadronic shower. This, we believe will be helpful in studying the very important phenomenon of hydrodynamic tunneling in a more quantitative manner. The details of this experimental work together with a comparison with the numerical

  7. Clinical implementation of full Monte Carlo dose calculation in proton beam therapy

    International Nuclear Information System (INIS)

    Paganetti, Harald; Jiang, Hongyu; Parodi, Katia; Slopsema, Roelf; Engelsman, Martijn

    2008-01-01

    The goal of this work was to facilitate the clinical use of Monte Carlo proton dose calculation to support routine treatment planning and delivery. The Monte Carlo code Geant4 was used to simulate the treatment head setup, including a time-dependent simulation of modulator wheels (for broad beam modulation) and magnetic field settings (for beam scanning). Any patient-field-specific setup can be modeled according to the treatment control system of the facility. The code was benchmarked against phantom measurements. Using a simulation of the ionization chamber reading in the treatment head allows the Monte Carlo dose to be specified in absolute units (Gy per ionization chamber reading). Next, the capability of reading CT data information was implemented into the Monte Carlo code to model patient anatomy. To allow time-efficient dose calculation, the standard Geant4 tracking algorithm was modified. Finally, a software link of the Monte Carlo dose engine to the patient database and the commercial planning system was established to allow data exchange, thus completing the implementation of the proton Monte Carlo dose calculation engine ('DoC++'). Monte Carlo re-calculated plans are a valuable tool to revisit decisions in the planning process. Identification of clinically significant differences between Monte Carlo and pencil-beam-based dose calculations may also drive improvements of current pencil-beam methods. As an example, four patients (29 fields in total) with tumors in the head and neck regions were analyzed. Differences between the pencil-beam algorithm and Monte Carlo were identified in particular near the end of range, both due to dose degradation and overall differences in range prediction due to bony anatomy in the beam path. Further, the Monte Carlo reports dose-to-tissue as compared to dose-to-water by the planning system. Our implementation is tailored to a specific Monte Carlo code and the treatment planning system XiO (Computerized Medical Systems Inc

  8. SU-F-T-214: Re-Thinking the Useful Clinical Beam Energy in Proton Therapy: An Opportunity for Cost Reduction

    Energy Technology Data Exchange (ETDEWEB)

    Bentefour, El H [IBA, Advanced Technology Group, Louvain La Neuve (Belgium); Lu, H [Massachusetts General Hospital and Harvard Medical School, Boston, MA (United States)

    2016-06-15

    Purpose: We conducted a retrospective study of the useful clinical proton beam energy based on the beam range data of patients treated over the last 10 years at Massachusetts General Hospital Proton Therapy Center. Methods: Treatment field information were collected for all patients treated over the last 10 years (2005–2015) in the two gantry treatment rooms at MGH. The beam ranges for these fields were retrieved and categorized per treatment site. The 10 prostate patients that required the highest beam range (lateral fields) were selected. For these patients, anterior oblique beams (30–40 degrees) were simulated in a planning system to obtain the required beam ranges including the margins for potential range uncertainties. Results: There were a total of 4033 patients, treated with combined total of 23603 fields. All treatment indications were considered with the exception of ocular tumors generally treated in a fixed beam room. For all non-prostate treatments (21811 fields), only 5 fields for 4 patients (1-pancreas, 1-lumbar chordoma, 2-spine mets) required beam range greater than 25 cm. There were 446 prostate patients (1792 fields), with the required beam range from 22.3 to 29.0 cm; 386 of them had at least one of their lateral beam range greater than 25 cm. For the 10 prostate patients with highest lateral beam ranges (26 to 29 cm), their treatment with anterior oblique beams would drop the beam ranges below 25 cm (17.3 to 18.5 cm). Conclusion: if prostate patients are treated with anterior fields only, the useful maximum beam range is reduced to 25 cm. Thus a proton therapy system with maximum beam energy of 196 MeV is sufficient to treat all tumors sites with very rare exceptions (<0.1%). Designing such PT system would reduce the cost of proton therapy for hospitals and patients and increase the accessibility to the treatment.

  9. SU-F-T-174: Patient-Specific Point Dose Measurement Using Fiber Optic Radiation Sensor Using Cerenkov Radiation for Proton Therapeutic Beam

    Energy Technology Data Exchange (ETDEWEB)

    Son, J [Korea University, Seoul, Seoul (Korea, Republic of); National Cancer Center, Goyang-si (Korea, Republic of); Kim, M [Dongnam Institute of Radiological & Medical Sciences, Busan, Busan (Korea, Republic of); Yoon, M [Korea University, Seoul (Korea, Republic of); Shin, D [National Cancer Center, Goyang-si (Korea, Republic of)

    2016-06-15

    Purpose: A fiber-optic radiation sensor using Cerenkov radiation (FOCR) has been widely studied for use as a dosimeter for proton therapeutic beam. We developed the FOCR, and it applied to patient-specific point dose measurement in order to evaluate the effectiveness of the FOCR system for proton therapy QA. Methods: Calibration of FOCR was performed with an ionization chamber whose absolute doses were determined according to the IAEA TRS-398 protocol. To determine the calibration curve, the FOCR was irradiated perpendicularly to the proton beam at the 13 dose levels steps. We selected five actual patient treatment plans performed at proton therapy center and compared the resulting FOCR measurements with the ionization chamber measurements. Results: The Cerenkov light yield of the FOCR increases linearly with as the dose measured using the ionization chamber increases from 0 cGy to 500 cGy. The results indicate that the fitting curve is linear, suggesting that dose measurement based on the light yield of the FOCR is possible. The results of proton radiation dose QA performed using the FOCR for 10 proton fields and five patients are good agreement with an ionization chamber. Conclusion: We carried out the patient QA using the FOCR for proton therapeutic beam and evaluated the effectiveness of the FOCR as a proton therapy QA tool. Our results indicate that the FOCR is suitable for use in patient QA of clinical proton beams.

  10. Proton-beam propagation through wall-confined plasma channel stabilized against sausage instability

    International Nuclear Information System (INIS)

    Nakahama, Masao; Nemoto, Masahiro; Masugata, Katsumi; Ito, Michiaki; Matsui, Masao; Yatsui, Kiyoshi

    1986-01-01

    Experimental results are presented of proton-beam (energy ∼ 650 keV) propagation through wall-confined plasma channel that is stabilized against sausage instability by an externally-applied longitudinal magnetic field. Significant improvement of beam-propagation efficiency has been obtained of ∼ 70 % compared with the previous experiment of ∼ 55 % without the magnetic field. The propagation can also be available up to ∼ 30 % even in a non-propagation region in a non-stabilized channel. (author)

  11. Inclusive production of protons, anti-protons, neutrons, deuterons and tritons in p+C collisions at 158 GeV/c beam momentum

    CERN Document Server

    Baatar, B.; Bartke, J.; Betev, L.; Chvala, O.; Dolejsi, J.; Eckardt, V.; Fischer, H.G.; Fodor, Z.; Karev, A.; Kolesnikov, V.; Kowalski, M.; Makariev, M.; Malakhov, A.; Mateev, M.; Melkumov, G.; Rybicki, A.; Schmitz, N.; Seyboth, P.; Stock, R.; Tinti, G.; Varga, D.; Vesztergombi, G.; Wenig, S.

    2013-04-09

    The production of protons, anti-protons, neutrons, deuterons and tritons in minimum bias p+C interactions is studied using a sample of 385 734 inelastic events obtained with the NA49 detector at the CERN SPS at 158 GeV/c beam momentum. The data cover a phase space area ranging from 0 to 1.9 GeV/c in transverse momentum and in Feynman x from -0.80 to 0.95 for protons, from -0.2 to 0.4 for anti-protons and from 0.2 to 0.95 for neutrons. Existing data in the far backward hemisphere are used to extend the coverage for protons and light nuclear fragments into the region of intranuclear cascading. The use of corresponding data sets obtained in hadron-proton collisions with the same detector allows for the detailed analysis and model-independent separation of the three principle components of hadronization in p+C interactions, namely projectile fragmentation, target fragmentation of participant nucleons and intranuclear cascading.

  12. Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions

    International Nuclear Information System (INIS)

    Berman, Abigail T.; James, Sara St.; Rengan, Ramesh

    2015-01-01

    Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT), through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung cancer, present the existing data in early-stage and locally-advanced non-small cell lung cancer (NSCLC), as well as in special situations such as re-irradiation and post-operative radiation therapy. We then present the technical challenges, such as anatomic changes and motion management, and future directions for PBT in lung cancer, including pencil beam scanning

  13. Proton beam dosimetry: a comparison between a plastic scintillator, ionization chamber and faraday cup

    International Nuclear Information System (INIS)

    Ghergherehchi, Mitra; Afarideh, Hossein; Mohammadzadeh, Ahmad; Boghrati, Behzad; Ghannadi, Mohammad; Aslani, Golam Reza

    2010-01-01

    In this study, a comparison was made between a plastic scintillator (BC400), a Faraday Cup (FC) and an ionization chamber (IC) used for routine proton dosimetry. Thin scintillators can be applied to proton dosimetry and consequently to proton therapy as relative dosimeters because of their water-equivalent nature, high energy-light conversion efficiency, low dimensions and good proportionality to the absorbed dose at low stopping powers. To employ such scintillators as relative dosimeters in proton therapy, the corrective factors must be applied to correct the quenching luminescence at the Bragg peak. A fine linear proportionality between the luminescence light yield Y and the proton flux in a thin (0.5 mm) scintillator for the 20 and 30 MeV proton beams were observed. The experimental peak/plateau ratios of Bragg Curve for 2, 1 and 0.5 mm scintillators with an accuracy of 0.5% were obtained to be 1.87, 1.91 and 2.30, respectively. With combination of the Markus chamber and the CR-39 detector, the peak/plateau ratio was improved to 3.26. The obtained data of the luminescence yield as a function of the specific energy loss is in agreement with the Craun-Birk's theory. Results show that the FC and Markus ionization chamber are in agreement within 4%, while the FC gives a lower dose evaluation. For a defined beam, the data for the fluence measurements are reproducible within a good accuracy. (author)

  14. Geant4 simulation of clinical proton and carbon ion beams for the treatment of ocular melanomas with the full 3-D pencil beam scanning system

    Energy Technology Data Exchange (ETDEWEB)

    Farina, Edoardo; Riccardi, Cristina; Rimoldi, Adele; Tamborini, Aurora [University of Pavia and the INFN section of Pavia, via Bassi 6, 27100 Pavia (Italy); Piersimoni, Pierluigi [Division of Radiation Research, Loma Linda University, Loma Linda, CA 92354 (United States); Ciocca, Mario [Medical Physics Unit, CNAO Foundation, Strada Campeggi 53, 27100 Pavia (Italy)

    2015-07-01

    This work investigates the possibility to use carbon ion beams delivered with active scanning modality, for the treatment of ocular melanomas at the Centro Nazionale di Adroterapia Oncologica (CNAO) in Pavia. The radiotherapy with carbon ions offers many advantages with respect to the radiotherapy with protons or photons, such as a higher relative radio-biological effectiveness (RBE) and a dose release better localized to the tumor. The Monte Carlo (MC) Geant4 10.00 patch-03 toolkit is used to reproduce the complete CNAO extraction beam line, including all the active and passive components characterizing it. The simulation of proton and carbon ion beams and radiation scanned field is validated against CNAO experimental data. For the irradiation study of the ocular melanoma an eye-detector, representing a model of a human eye, is implemented in the simulation. Each element of the eye is reproduced with its chemical and physical properties. Inside the eye-detector a realistic tumor volume is placed and used as the irradiation target. A comparison between protons and carbon ions eye irradiations allows to study possible treatment benefits if carbon ions are used instead of protons. (authors)

  15. Photoluminescence of radiation-induced color centers in lithium fluoride thin films for advanced diagnostics of proton beams

    Science.gov (United States)

    Piccinini, M.; Ambrosini, F.; Ampollini, A.; Picardi, L.; Ronsivalle, C.; Bonfigli, F.; Libera, S.; Nichelatti, E.; Vincenti, M. A.; Montereali, R. M.

    2015-06-01

    Systematic irradiation of thermally evaporated 0.8 μm thick polycrystalline lithium fluoride films on glass was performed by proton beams of 3 and 7 MeV energies, produced by a linear accelerator, in a fluence range from 1011 to 1015 protons/cm2. The visible photoluminescence spectra of radiation-induced F2 and F3+ laser active color centers, which possess almost overlapping absorption bands at about 450 nm, were measured under laser pumping at 458 nm. On the basis of simulations of the linear energy transfer with proton penetration depth in LiF, it was possible to obtain the behavior of the measured integrated photoluminescence intensity of proton irradiated LiF films as a function of the deposited dose. The photoluminescence signal is linearly dependent on the deposited dose in the interval from 103 to about 106 Gy, independently from the used proton energies. This behavior is very encouraging for the development of advanced solid state radiation detectors based on optically transparent LiF thin films for proton beam diagnostics and two-dimensional dose mapping.

  16. Partial Breast Radiation Therapy With Proton Beam: 5-Year Results With Cosmetic Outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Bush, David A., E-mail: dbush@llu.edu [Department of Radiation Oncology, Loma Linda University Medical Center, Loma Linda, California (United States); Do, Sharon [Department of Radiation Oncology, Loma Linda University Medical Center, Loma Linda, California (United States); Lum, Sharon; Garberoglio, Carlos [Department of Surgical Oncology, Loma Linda University Medical Center, Loma Linda, California (United States); Mirshahidi, Hamid [Department of Medical Oncology, Loma Linda University Medical Center, Loma Linda, California (United States); Patyal, Baldev; Grove, Roger; Slater, Jerry D. [Department of Radiation Oncology, Loma Linda University Medical Center, Loma Linda, California (United States)

    2014-11-01

    Purpose: We updated our previous report of a phase 2 trial using proton beam radiation therapy to deliver partial breast irradiation (PBI) in patients with early stage breast cancer. Methods and Materials: Eligible subjects had invasive nonlobular carcinoma with a maximal dimension of 3 cm. Patients underwent partial mastectomy with negative margins; axillary lymph nodes were negative on sampling. Subjects received postoperative proton beam radiation therapy to the surgical bed. The dose delivered was 40 Gy in 10 fractions, once daily over 2 weeks. Multiple fields were treated daily, and skin-sparing techniques were used. Following treatment, patients were evaluated with clinical assessments and annual mammograms to monitor toxicity, tumor recurrence, and cosmesis. Results: One hundred subjects were enrolled and treated. All patients completed the assigned treatment and were available for post-treatment analysis. The median follow-up was 60 months. Patients had a mean age of 63 years; 90% had ductal histology; the average tumor size was 1.3 cm. Actuarial data at 5 years included ipsilateral breast tumor recurrence-free survival of 97% (95% confidence interval: 100%-93%); disease-free survival of 94%; and overall survival of 95%. There were no cases of grade 3 or higher acute skin reactions, and late skin reactions included 7 cases of grade 1 telangiectasia. Patient- and physician-reported cosmesis was good to excellent in 90% of responses, was not changed from baseline measurements, and was well maintained throughout the entire 5-year follow-up period. Conclusions: Proton beam radiation therapy for PBI produced excellent ipsilateral breast recurrence-free survival with minimal toxicity. The treatment proved to be adaptable to all breast sizes and lumpectomy cavity configurations. Cosmetic results appear to be excellent and unchanged from baseline out to 5 years following treatment. Cosmetic results may be improved over those reported with photon

  17. Envelope model for passive magnetic focusing of an intense proton or ion beam propagating through thin foils

    Directory of Open Access Journals (Sweden)

    Steven M. Lund

    2013-04-01

    Full Text Available Ion beams (including protons with low emittance and high space-charge intensity can be propagated with normal incidence through a sequence of thin metallic foils separated by vacuum gaps of order the characteristic transverse beam extent to transport/collimate the beam or to focus it to a small transverse spot. Energetic ions have sufficient range to pass through a significant number of thin foils with little energy loss or scattering. The foils reduce the (defocusing radial electric self-field of the beam while not altering the (focusing azimuthal magnetic self-field of the beam, thereby allowing passive self-beam focusing if the magnetic field is sufficiently strong relative to the residual electric field. Here we present an envelope model developed to predict the strength of this passive (beam generated focusing effect under a number of simplifying assumptions including relatively long pulse duration. The envelope model provides a simple criterion for the necessary foil spacing for net focusing and clearly illustrates system focusing properties for either beam collimation (such as injecting a laser-produced proton beam into an accelerator or for magnetic pinch focusing to a small transverse spot (for beam driven heating of materials. An illustrative example is worked for an idealization of a recently performed laser-produced proton-beam experiment to provide guidance on possible beam focusing and collimation systems. It is found that foils spaced on the order of the characteristic transverse beam size desired can be employed and that envelope divergence of the initial beam entering the foil lens must be suppressed to limit the total number of foils required to practical values for pinch focusing. Relatively modest proton-beam current at 10 MeV kinetic energy can clearly demonstrate strong magnetic pinch focusing achieving a transverse rms extent similar to the foil spacing (20–50  μm gaps in beam propagation distances of tens of mm

  18. High intensity proton accelerator and its application (Proton Engineering Center)

    International Nuclear Information System (INIS)

    Tanaka, Shun-ichi

    1995-01-01

    A plan called PROTON ENGINEERING CENTER has been proposed in JAERI. The center is a complex composed of research facilities and a beam shape and storage ring based on a proton linac with an energy of 1.5 GeV and an average current of 10 mA. The research facilities planned are OMEGA·Nuclear Energy Development Facility, Neutron Facility for Material Irradiation, Nuclear Data Experiment Facility, Neutron Factory, Meson Factory, Spallation Radioisotope Beam Facility, and Medium Energy Experiment Facility, where high intensity proton beam and secondary particle beams such as neutrons, π-mesons, muons, and unstable isotopes originated from the protons are available for promoting the innovative research of nuclear energy and basic science and technology. (author)

  19. Proton Beam Intensity Upgrades for the Neutrino Program at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Bhat, C. M. [Fermilab

    2016-12-15

    Fermilab is committed to upgrading its accelerator complex towards the intensity frontier to pursue HEP research in the neutrino sector and beyond. The upgrade has two steps: 1) the Proton Improvement Plan (PIP), which is underway, has its primary goal to start providing 700 kW beam power on NOvA target by the end of 2017 and 2) the foreseen PIP–II will replace the existing LINAC, a 400 MeV injector to the Booster, by an 800 MeV superconducting LINAC by the middle of next decade, with output beam intensity from the Booster increased significantly and the beam power on the NOvA target increased to <1.2 MW. In any case, the Fermilab Booster is going to play a very significant role for the next two decades. In this context, we have recently developed and commissioned an innovative beam injection scheme for the Booster called "early injection scheme". This scheme is already in operation and has a potential to increase the Booster beam intensity from the PIP design goal by a considerable amount with a reduced beam emittance and beam loss. In this paper, we will present results from our experience from the new scheme in operation, current status and future plans.

  20. Numerical simulations of energy deposition caused by 50 MeV—50 TeV proton beams in copper and graphite targets

    CERN Document Server

    Nie, Y; Chetvertkova, V; Rosell-Tarrago, G; Burkart, F; Wollmann, D

    2017-01-01

    The conceptual design of the Future Circular Collider (FCC) is being carried out actively in an international collaboration hosted by CERN, for the post–Large Hadron Collider (LHC) era. The target center-of-mass energy of proton-proton collisions for the FCC is 100 TeV, nearly an order of magnitude higher than for LHC. The existing CERN accelerators will be used to prepare the beams for FCC. Concerning beam-related machine protection of the whole accelerator chain, it is critical to assess the consequences of beam impact on various accelerator components in the cases of controlled and uncontrolled beam losses. In this paper, we study the energy deposition of protons in solid copper and graphite targets, since the two materials are widely used in magnets, beam screens, collimators, and beam absorbers. Nominal injection and extraction energies in the hadron accelerator complex at CERN were selected in the range of 50 MeV–50 TeV. Three beam sizes were studied for each energy, corresponding to typical values ...

  1. Si Micro-turbine by Proton BeamWriting and Porous Silicon Micromachining

    International Nuclear Information System (INIS)

    Rajta, I.; Szilasi, S.Z.; Fekete, Z.

    2008-01-01

    Complete text of publication follows. A 3D Si micro-turbine characterized by high aspect ratio vertical walls was formed by the combination of proton beam writing (PBW) and subsequent selective porous Si (PS) etching. Crystal damages generated by the implanted protons result in increased resistivity, thereby limit or even prevent the current to flow through the implanted area during electrochemical etching. Characteristic feature of the proposed process is that the shape of the micro electromechanical (MEMS) components is defined by two implantation energies. A higher energy is applied for defining the housing of the device while the lower energy is used to write the moving components. The implantation energies were selected such as to result appropriate difference between the two projected ranges, thereby providing structures with different height after development. The thickness of the walls of the moving component and the isotropic etching profile of the electrochemical PS formation was also taken into consideration. The electrochemical etching is driven until the sacrificial PS layer completely under etches the moving components, but the etch-front does not reach the bottom of the housing. Therefore, the dissolution of PS results in a ready-to-operate device with a released moving component embedded in the cavity of the housing. The operation of the encapsulated device fabricated by the two-energy implantation is successfully demonstrated (Fig. 1). Rotation speed of the device is estimated in the range of thousands rpm, however, further analysis of the novel structure optimized for performance and MEMS compatible assembly will be done and precise characteristics will be determined by adequate optical read-out method. The feasibility of Proton Beam Writing combined with Porous Si Micromachining and conventional Si processing steps was successfully demonstrated by fabricating Si microturbine chip. The aligned, two-energy proton beam implantation can provide high

  2. Resist materials for proton beam writing: A review

    Energy Technology Data Exchange (ETDEWEB)

    Kan, J.A. van, E-mail: phyjavk@nus.edu.sg [Centre for Ion Beam Applications, Physics Department, 2 Science Drive 3, National University of Singapore, 117542 Singapore (Singapore); Malar, P. [Research Institute, SRM University, Kattankulathur, Chennai 603203 (India); Wang, Y.H. [Centre for Ion Beam Applications, Physics Department, 2 Science Drive 3, National University of Singapore, 117542 Singapore (Singapore)

    2014-08-15

    Highlights: • PBW can now achieve 19 nm details in HSQ and 65 nm in PMMA. • A complete table of resist materials for PBW has been presented, including minimum feature size, achievable aspect ratio, suitability for electroplating and where available contrast of the resist. • PBW fabricated molds can now be used for single DNA molecule detection, single DNA manipulation and large scale Genome mapping. - Abstract: Proton beam writing (PBW) is a lithographic technique that has been developed since the mid 1990s, initially in Singapore followed by several groups around the world. MeV protons while penetrating materials will maintain a practically straight path. During the continued slowing down of a proton in material it will mainly interact with substrate electrons and transfer a small amount of energy to each electron, the induced secondary electrons will modify the molecular structure of resist within a few nanometers around the proton track. The recent demonstration of high aspect ratio sub 20 nm lithography in HSQ shows the potential of PBW. To explore the full capabilities of PBW, the understanding of the interaction of fast protons with different resist materials is important. Here we give an update of the growing number of resist materials that have been evaluated for PBW. In particular we evaluate the exposure and development strategies for the most promising resist materials like PMMA, HSQ, SU-8 and AR-P and compare their characteristics with respect to properties such as contrast and sensitivity. Besides an updated literature survey we also present new findings on AR-P and PMGI resists. Since PBW is a direct write technology it is important to look for fast ways to replicate micro and nanostructures. In this respect we will discuss the suitability and performance of several resists for Ni electroplating for mold fabrication in nano imprint technologies. We will summarize with an overview of proton resist characteristics like sensitivity, contrast

  3. Resist materials for proton beam writing: A review

    International Nuclear Information System (INIS)

    Kan, J.A. van; Malar, P.; Wang, Y.H.

    2014-01-01

    Highlights: • PBW can now achieve 19 nm details in HSQ and 65 nm in PMMA. • A complete table of resist materials for PBW has been presented, including minimum feature size, achievable aspect ratio, suitability for electroplating and where available contrast of the resist. • PBW fabricated molds can now be used for single DNA molecule detection, single DNA manipulation and large scale Genome mapping. - Abstract: Proton beam writing (PBW) is a lithographic technique that has been developed since the mid 1990s, initially in Singapore followed by several groups around the world. MeV protons while penetrating materials will maintain a practically straight path. During the continued slowing down of a proton in material it will mainly interact with substrate electrons and transfer a small amount of energy to each electron, the induced secondary electrons will modify the molecular structure of resist within a few nanometers around the proton track. The recent demonstration of high aspect ratio sub 20 nm lithography in HSQ shows the potential of PBW. To explore the full capabilities of PBW, the understanding of the interaction of fast protons with different resist materials is important. Here we give an update of the growing number of resist materials that have been evaluated for PBW. In particular we evaluate the exposure and development strategies for the most promising resist materials like PMMA, HSQ, SU-8 and AR-P and compare their characteristics with respect to properties such as contrast and sensitivity. Besides an updated literature survey we also present new findings on AR-P and PMGI resists. Since PBW is a direct write technology it is important to look for fast ways to replicate micro and nanostructures. In this respect we will discuss the suitability and performance of several resists for Ni electroplating for mold fabrication in nano imprint technologies. We will summarize with an overview of proton resist characteristics like sensitivity, contrast

  4. Prospects for studies of ground-state proton decays with the Holifield Radioactive Ion Beam Facility

    International Nuclear Information System (INIS)

    Toth, K.S.

    1994-01-01

    By using radioactive ions from the Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory it should be possible to identify many new ground-state proton emitters in the mass region from Sn to Pb. During this production and search process the limits of stability on the proton-rich side of the nuclidic chart will be delineated for a significant fraction of medium-weight elements and our understanding of the proton-emission process will be expanded and improved

  5. Preliminary Comparison of the Response of LHC Tertiary Collimators to Proton and Ion Beam Impacts

    CERN Document Server

    Cauchi, M; Bertarelli, A; Carra, F; Cerutti, F; Lari, L; Mollicone, P; Sammut, N

    2013-01-01

    The CERN Large Hadron Collider is designed to bring into collision protons as well as heavy ions. Accidents involving impacts on collimators can happen for both species. The interaction of lead ions with matter differs to that of protons, thus making this scenario a new interesting case to study as it can result in different damage aspects on the collimator. This paper will present a preliminary comparison of the response of collimators to proton and ion beam impacts.

  6. Analyzing-power measurements of Coulomb-nuclear interference with the polarized-proton and -antiproton beams at 185 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Akchurin, N; Onel, Y [Iowa Univ., Iowa City, IA (USA). Dept. of Physics; Carey, D; Coleman, R; Cossairt, J D; Read, A L [Fermi National Accelerator Lab., Batavia, IL (USA); Corcoran, M D; Nessi-Tedaldi, F; Nessi, M; Nguyen, C; Phillips, G C; Roberts, J B; White, J L [Rice Univ., Houston, TX (USA). Bonner Nuclear Labs.; Derevschikov, A; Matulenko, Yu A; Meschanin, A P; Nurushev, S B; Solovyanov, V L; Vasiliev, A N [Institut Fiziki Vysokikh Ehnergij, Serpukhov (USSR); Gazzaly, M M [Minnesota Univ., Minneapolis (USA). Dept. of Physics; Grosnick, D P; Hill, D; Laghai, M; Lopiano, D; Ohashi, Y; Shima, T; Spinka, H; Stanek, R W; Underwood, D G; Yokosawa, A [Argonne National Lab., IL (USA); Imai, K; Makino, S; Masaike, A; Miyake, K; Nagamine, T; Takeutchi, F; Tamura, N; Yoshida, T [Kyoto Univ. (Japan); Kuroda, K; Michalowicz, A [Institut National de Physique Nucleaire et de Physique des Particules, 74 - Annecy-le-Vieux (France). Lab. de P; E-581/704 Collaboration

    1989-10-12

    The analyzing power A{sub N} of proton-proton, proton-hydrocarbon, and antiproton-hydrocarbon scattering in the Coulomb-nuclear interference region has been measured using the 185 GeV/c Fermilab polarized-proton and -antiproton beams. The results are found to be consistent with theoretical predictions within statistical uncertainties. (orig.).

  7. Measurements of LET Spectra of the JINR Phasotron Radiotherapy Proton Beam

    Czech Academy of Sciences Publication Activity Database

    Kubančák, Ján; Molokanov, A. G.

    2013-01-01

    Roč. 2013, č. 6 (2013), s. 90-92 ISSN 1562-6016 R&D Projects: GA MŠk LA08002 Institutional support: RVO:61389005 Keywords : LET spectra * proton beam Subject RIV: BO - Biophysics Impact factor: 0.102, year: 2013 http:// vant .kipt.kharkov.ua/ARTICLE/ VANT _2013_6/article_2013_6_90.pdf

  8. Prospects of warm dense matter research at HiRadMat facility at CERN using 440 MeV SPS proton beam

    CERN Document Server

    Tahir, N A; Schmidt, R; Shutov, A; Piriz, A R

    2013-01-01

    In this paper we present numerical simulations of heating of a solid copper cylinder by the 440 GeV proton beam delivered by the Super Proton Synchrotron (SPS) at CERN. The beam is made of 288 proton bunches while each bunch comprises of 1.15$1011 so that the total number of protons in the beam is about 1.3$1013. The bunch length is 0.5 ns while two neighboring bunches are separated by 25 ns so that the beam duration is 7.2 ms. Particle intensity distribution in the transverse direction is a Gaussian and the beam can be focused to a spot size with s 1⁄4 0.1 mme1.0 mm. In this paper we present results using two values of s, namely 0.2 mm and 0.5 mm, respectively. The target length is 1.5 m with a radius 1⁄4 5 cm and is facially irradiated by the beam. The energy deposition code FLUKA and the two-dimensional hydrodynamic code BIG2 are employed using a suitable iteration time to simulate the hydrodynamic and the thermodynamic response of the target. The primary purpose of this work was to design fixed target...

  9. Evaluation of ion chamber dependent correction factors for ionisation chamber dosimetry in proton beams using a Monte Carlo method

    Energy Technology Data Exchange (ETDEWEB)

    Palmans, H [Ghent Univ. (Belgium). Dept. of Biomedical Physics; Verhaegen, F

    1995-12-01

    In the last decade, several clinical proton beam therapy facilities have been developed. To satisfy the demand for uniformity in clinical (routine) proton beam dosimetry two dosimetry protocols (ECHED and AAPM) have been published. Both protocols neglect the influence of ion chamber dependent parameters on dose determination in proton beams because of the scatter properties of these beams, although the problem has not been studied thoroughly yet. A comparison between water calorimetry and ionisation chamber dosimetry showed a discrepancy of 2.6% between the former method and ionometry following the ECHED protocol. Possibly, a small part of this difference can be attributed to chamber dependent correction factors. Indications for this possibility are found in ionometry measurements. To allow the simulation of complex geometries with different media necessary for the study of those corrections, an existing proton Monte Carlo code (PTRAN, Berger) has been modified. The original code, that applies Mollire`s multiple scattering theory and Vavilov`s energy straggling theory, calculates depth dose profiles, energy distributions and radial distributions for pencil beams in water. Comparisons with measurements and calculations reported in the literature are done to test the program`s accuracy. Preliminary results of the influence of chamber design and chamber materials on dose to water determination are presented.

  10. Evaluation of ion chamber dependent correction factors for ionisation chamber dosimetry in proton beams using a Monte Carlo method

    International Nuclear Information System (INIS)

    Palmans, H.; Verhaegen, F.

    1995-01-01

    In the last decade, several clinical proton beam therapy facilities have been developed. To satisfy the demand for uniformity in clinical (routine) proton beam dosimetry two dosimetry protocols (ECHED and AAPM) have been published. Both protocols neglect the influence of ion chamber dependent parameters on dose determination in proton beams because of the scatter properties of these beams, although the problem has not been studied thoroughly yet. A comparison between water calorimetry and ionisation chamber dosimetry showed a discrepancy of 2.6% between the former method and ionometry following the ECHED protocol. Possibly, a small part of this difference can be attributed to chamber dependent correction factors. Indications for this possibility are found in ionometry measurements. To allow the simulation of complex geometries with different media necessary for the study of those corrections, an existing proton Monte Carlo code (PTRAN, Berger) has been modified. The original code, that applies Mollire's multiple scattering theory and Vavilov's energy straggling theory, calculates depth dose profiles, energy distributions and radial distributions for pencil beams in water. Comparisons with measurements and calculations reported in the literature are done to test the program's accuracy. Preliminary results of the influence of chamber design and chamber materials on dose to water determination are presented

  11. Characterisation and mitigation of beam-induced backgrounds observed in the ATLAS detector during the 2011 proton-proton run

    CERN Document Server

    Aad, Georges; Abbott, Brad; Abdallah, Jalal; Abdel Khalek, Samah; Abdelalim, Ahmed Ali; Abdinov, Ovsat; Aben, Rosemarie; Abi, Babak; Abolins, Maris; AbouZeid, Ossama; Abramowicz, Halina; Abreu, Henso; Acharya, Bobby Samir; Adamczyk, Leszek; Adams, David; Addy, Tetteh; Adelman, Jahred; Adomeit, Stefanie; Adragna, Paolo; Adye, Tim; Aefsky, Scott; Aguilar-Saavedra, Juan Antonio; Agustoni, Marco; Aharrouche, Mohamed; Ahlen, Steven; Ahles, Florian; Ahmad, Ashfaq; Ahsan, Mahsana; Aielli, Giulio; Akdogan, Taylan; Åkesson, Torsten Paul Ake; Akimoto, Ginga; Akimov, Andrei; Alam, Mohammad; Alam, Muhammad Aftab; Albert, Justin; Albrand, Solveig; Aleksa, Martin; Aleksandrov, Igor; Alessandria, Franco; Alexa, Calin; Alexander, Gideon; Alexandre, Gauthier; Alexopoulos, Theodoros; Alhroob, Muhammad; Aliev, Malik; Alimonti, Gianluca; Alison, John; Allbrooke, Benedict; Allport, Phillip; Allwood-Spiers, Sarah; Almond, John; Aloisio, Alberto; Alon, Raz; Alonso, Alejandro; Alonso, Francisco; Altheimer, Andrew David; Alvarez Gonzalez, Barbara; Alviggi, Mariagrazia; Amako, Katsuya; Amelung, Christoph; Ammosov, Vladimir; Amor Dos Santos, Susana Patricia; Amorim, Antonio; Amram, Nir; Anastopoulos, Christos; Ancu, Lucian Stefan; Andari, Nansi; Andeen, Timothy; Anders, Christoph Falk; Anders, Gabriel; Anderson, Kelby; Andreazza, Attilio; Andrei, George Victor; Andrieux, Marie-Laure; Anduaga, Xabier; Angelidakis, Stylianos; Anger, Philipp; Angerami, Aaron; Anghinolfi, Francis; Anisenkov, Alexey; Anjos, Nuno; Annovi, Alberto; Antonaki, Ariadni; Antonelli, Mario; Antonov, Alexey; Antos, Jaroslav; Anulli, Fabio; Aoki, Masato; Aoun, Sahar; Aperio Bella, Ludovica; Apolle, Rudi; Arabidze, Giorgi; Aracena, Ignacio; Arai, Yasuo; Arce, Ayana; Arfaoui, Samir; Arguin, Jean-Francois; Argyropoulos, Spyridon; Arik, Engin; Arik, Metin; Armbruster, Aaron James; Arnaez, Olivier; Arnal, Vanessa; Arnault, Christian; Artamonov, Andrei; Artoni, Giacomo; Arutinov, David; Asai, Shoji; Ask, Stefan; Åsman, Barbro; Asquith, Lily; Assamagan, Ketevi; Astbury, Alan; Atkinson, Markus; Aubert, Bernard; Auge, Etienne; Augsten, Kamil; Aurousseau, Mathieu; Avolio, Giuseppe; Avramidou, Rachel Maria; Axen, David; Azuelos, Georges; Azuma, Yuya; Baak, Max; Baccaglioni, Giuseppe; Bacci, Cesare; Bach, Andre; Bachacou, Henri; Bachas, Konstantinos; Backes, Moritz; Backhaus, Malte; Backus Mayes, John; Badescu, Elisabeta; Bagnaia, Paolo; Bahinipati, Seema; Bai, Yu; Bailey, David; Bain, Travis; Baines, John; Baker, Oliver Keith; Baker, Mark; Baker, Sarah; Balek, Petr; Banas, Elzbieta; Banerjee, Piyali; Banerjee, Swagato; Banfi, Danilo; Bangert, Andrea Michelle; Bansal, Vikas; Bansil, Hardeep Singh; Barak, Liron; Baranov, Sergei; Barbaro Galtieri, Angela; Barber, Tom; Barberio, Elisabetta Luigia; Barberis, Dario; Barbero, Marlon; Bardin, Dmitri; Barillari, Teresa; Barisonzi, Marcello; Barklow, Timothy; Barlow, Nick; Barnett, Bruce; Barnett, Michael; Baroncelli, Antonio; Barone, Gaetano; Barr, Alan; Barreiro, Fernando; Barreiro Guimarães da Costa, João; Barrillon, Pierre; Bartoldus, Rainer; Barton, Adam Edward; Bartsch, Valeria; Basye, Austin; Bates, Richard; Batkova, Lucia; Batley, Richard; Battaglia, Andreas; Battistin, Michele; Bauer, Florian; Bawa, Harinder Singh; Beale, Steven; Beau, Tristan; Beauchemin, Pierre-Hugues; Beccherle, Roberto; Bechtle, Philip; Beck, Hans Peter; Becker, Anne Kathrin; Becker, Sebastian; Beckingham, Matthew; Becks, Karl-Heinz; Beddall, Andrew; Beddall, Ayda; Bedikian, Sourpouhi; Bednyakov, Vadim; Bee, Christopher; Beemster, Lars; Begel, Michael; Behar Harpaz, Silvia; Behera, Prafulla; Beimforde, Michael; Belanger-Champagne, Camille; Bell, Paul; Bell, William; Bella, Gideon; Bellagamba, Lorenzo; Bellomo, Massimiliano; Belloni, Alberto; Beloborodova, Olga; Belotskiy, Konstantin; Beltramello, Olga; Benary, Odette; Benchekroun, Driss; Bendtz, Katarina; Benekos, Nektarios; Benhammou, Yan; Benhar Noccioli, Eleonora; Benitez Garcia, Jorge-Armando; Benjamin, Douglas; Benoit, Mathieu; Bensinger, James; Benslama, Kamal; Bentvelsen, Stan; Berge, David; Bergeaas Kuutmann, Elin; Berger, Nicolas; Berghaus, Frank; Berglund, Elina; Beringer, Jürg; Bernat, Pauline; Bernhard, Ralf; Bernius, Catrin; Berry, Tracey; Bertella, Claudia; Bertin, Antonio; Bertolucci, Federico; Besana, Maria Ilaria; Besjes, Geert-Jan; Besson, Nathalie; Bethke, Siegfried; Bhimji, Wahid; Bianchi, Riccardo-Maria; Bianchini, Louis; Bianco, Michele; Biebel, Otmar; Bieniek, Stephen Paul; Bierwagen, Katharina; Biesiada, Jed; Biglietti, Michela; Bilokon, Halina; Bindi, Marcello; Binet, Sebastien; Bingul, Ahmet; Bini, Cesare; Biscarat, Catherine; Bittner, Bernhard; Black, Kevin; Blair, Robert; Blanchard, Jean-Baptiste; Blanchot, Georges; Blazek, Tomas; Bloch, Ingo; Blocker, Craig; Blocki, Jacek; Blondel, Alain; Blum, Walter; Blumenschein, Ulrike; Bobbink, Gerjan; Bobrovnikov, Victor; Bocchetta, Simona Serena; Bocci, Andrea; Boddy, Christopher Richard; Boehler, Michael; Boek, Jennifer; Boek, Thorsten Tobias; Boelaert, Nele; Bogaerts, Joannes Andreas; Bogdanchikov, Alexander; Bogouch, Andrei; Bohm, Christian; Bohm, Jan; Boisvert, Veronique; Bold, Tomasz; Boldea, Venera; Bolnet, Nayanka Myriam; Bomben, Marco; Bona, Marcella; Boonekamp, Maarten; Bordoni, Stefania; Borer, Claudia; Borisov, Anatoly; Borissov, Guennadi; Borjanovic, Iris; Borri, Marcello; Borroni, Sara; Bortfeldt, Jonathan; Bortolotto, Valerio; Bos, Kors; Boscherini, Davide; Bosman, Martine; Boterenbrood, Hendrik; Bouchami, Jihene; Boudreau, Joseph; Bouhova-Thacker, Evelina Vassileva; Boumediene, Djamel Eddine; Bourdarios, Claire; Bousson, Nicolas; Boveia, Antonio; Boyd, James; Boyko, Igor; Bozovic-Jelisavcic, Ivanka; Bracinik, Juraj; Branchini, Paolo; Brandt, Andrew; Brandt, Gerhard; Brandt, Oleg; Bratzler, Uwe; Brau, Benjamin; Brau, James; Braun, Helmut; Brazzale, Simone Federico; Brelier, Bertrand; Bremer, Johan; Brendlinger, Kurt; Brenner, Richard; Bressler, Shikma; Britton, Dave; Brochu, Frederic; Brock, Ian; Brock, Raymond; Broggi, Francesco; Bromberg, Carl; Bronner, Johanna; Brooijmans, Gustaaf; Brooks, Timothy; Brooks, William; Brown, Gareth; Brown, Heather; Bruce, Roderik; Bruckman de Renstrom, Pawel; Bruncko, Dusan; Bruneliere, Renaud; Brunet, Sylvie; Bruni, Alessia; Bruni, Graziano; Bruschi, Marco; Buanes, Trygve; Buat, Quentin; Bucci, Francesca; Buchanan, James; Buchholz, Peter; Buckingham, Ryan; Buckley, Andrew; Buda, Stelian Ioan; Budagov, Ioulian; Budick, Burton; Büscher, Volker; Bugge, Lars; Bulekov, Oleg; Bundock, Aaron Colin; Bunse, Moritz; Buran, Torleiv; Burckhart, Helfried; Burdin, Sergey; Burgess, Thomas; Burke, Stephen; Busato, Emmanuel; Bussey, Peter; Buszello, Claus-Peter; Butler, Bart; Butler, John; Buttar, Craig; Butterworth, Jonathan; Buttinger, William; Byszewski, Marcin; Cabrera Urbán, Susana; Caforio, Davide; Cakir, Orhan; Calafiura, Paolo; Calderini, Giovanni; Calfayan, Philippe; Calkins, Robert; Caloba, Luiz; Caloi, Rita; Calvet, David; Calvet, Samuel; Camacho Toro, Reina; Camarri, Paolo; Cameron, David; Caminada, Lea Michaela; Caminal Armadans, Roger; Campana, Simone; Campanelli, Mario; Canale, Vincenzo; Canelli, Florencia; Canepa, Anadi; Cantero, Josu; Cantrill, Robert; Capasso, Luciano; Capeans Garrido, Maria Del Mar; Caprini, Irinel; Caprini, Mihai; Capriotti, Daniele; Capua, Marcella; Caputo, Regina; Cardarelli, Roberto; Carli, Tancredi; Carlino, Gianpaolo; Carminati, Leonardo; Caron, Bryan; Caron, Sascha; Carquin, Edson; Carrillo-Montoya, German D; Carter, Antony; Carter, Janet; Carvalho, João; Casadei, Diego; Casado, Maria Pilar; Cascella, Michele; Caso, Carlo; Castaneda Hernandez, Alfredo Martin; Castaneda-Miranda, Elizabeth; Castillo Gimenez, Victoria; Castro, Nuno Filipe; Cataldi, Gabriella; Catastini, Pierluigi; Catinaccio, Andrea; Catmore, James; Cattai, Ariella; Cattani, Giordano; Caughron, Seth; Cavaliere, Viviana; Cavalleri, Pietro; Cavalli, Donatella; Cavalli-Sforza, Matteo; Cavasinni, Vincenzo; Ceradini, Filippo; Santiago Cerqueira, Augusto; Cerri, Alessandro; Cerrito, Lucio; Cerutti, Fabio; Cetin, Serkant Ali; Chafaq, Aziz; Chakraborty, Dhiman; Chalupkova, Ina; Chan, Kevin; Chang, Philip; Chapleau, Bertrand; Chapman, John Derek; Chapman, John Wehrley; Chareyre, Eve; Charlton, Dave; Chavda, Vikash; Chavez Barajas, Carlos Alberto; Cheatham, Susan; Chekanov, Sergei; Chekulaev, Sergey; Chelkov, Gueorgui; Chelstowska, Magda Anna; Chen, Chunhui; Chen, Hucheng; Chen, Shenjian; Chen, Xin; Chen, Yujiao; Cheng, Yangyang; Cheplakov, Alexander; Cherkaoui El Moursli, Rajaa; Chernyatin, Valeriy; Cheu, Elliott; Cheung, Sing-Leung; Chevalier, Laurent; Chiefari, Giovanni; Chikovani, Leila; Childers, John Taylor; Chilingarov, Alexandre; Chiodini, Gabriele; Chisholm, Andrew; Chislett, Rebecca Thalatta; Chitan, Adrian; Chizhov, Mihail; Choudalakis, Georgios; Chouridou, Sofia; Christidi, Ilektra-Athanasia; Christov, Asen; Chromek-Burckhart, Doris; Chu, Ming-Lee; Chudoba, Jiri; Ciapetti, Guido; Ciftci, Abbas Kenan; Ciftci, Rena; Cinca, Diane; Cindro, Vladimir; Ciocca, Claudia; Ciocio, Alessandra; Cirilli, Manuela; Cirkovic, Predrag; Citron, Zvi Hirsh; Citterio, Mauro; Ciubancan, Mihai; Clark, Allan G; Clark, Philip James; Clarke, Robert; Cleland, Bill; Clemens, Jean-Claude; Clement, Benoit; Clement, Christophe; Coadou, Yann; Cobal, Marina; Coccaro, Andrea; Cochran, James H; Coffey, Laurel; Cogan, Joshua Godfrey; Coggeshall, James; Cogneras, Eric; Colas, Jacques; Cole, Stephen; Colijn, Auke-Pieter; Collins, Neil; Collins-Tooth, Christopher; Collot, Johann; Colombo, Tommaso; Colon, German; Compostella, Gabriele; Conde Muiño, Patricia; Coniavitis, Elias; Conidi, Maria Chiara; Consonni, Sofia Maria; Consorti, Valerio; Constantinescu, Serban; Conta, Claudio; Conti, Geraldine; Conventi, Francesco; Cooke, Mark; Cooper, Ben; Cooper-Sarkar, Amanda; Copic, Katherine; Cornelissen, Thijs; Corradi, Massimo; Corriveau, Francois; Cortes-Gonzalez, Arely; Cortiana, Giorgio; Costa, Giuseppe; Costa, María José; Costanzo, Davide; Côté, David; Courneyea, Lorraine; Cowan, Glen; Cowden, Christopher; Cox, Brian; Cranmer, Kyle; Crescioli, Francesco; Cristinziani, Markus; Crosetti, Giovanni; Crépé-Renaudin, Sabine; Cuciuc, Constantin-Mihai; Cuenca Almenar, Cristóbal; Cuhadar Donszelmann, Tulay; Cummings, Jane; Curatolo, Maria; Curtis, Chris; Cuthbert, Cameron; Cwetanski, Peter; Czirr, Hendrik; Czodrowski, Patrick; Czyczula, Zofia; D'Auria, Saverio; D'Onofrio, Monica; D'Orazio, Alessia; Da Cunha Sargedas De Sousa, Mario Jose; Da Via, Cinzia; Dabrowski, Wladyslaw; Dafinca, Alexandru; Dai, Tiesheng; Dallapiccola, Carlo; Dam, Mogens; Dameri, Mauro; Damiani, Daniel; Danielsson, Hans Olof; Dao, Valerio; Darbo, Giovanni; Darlea, Georgiana Lavinia; Dassoulas, James; Davey, Will; Davidek, Tomas; Davidson, Nadia; Davidson, Ruth; Davies, Eleanor; Davies, Merlin; Davignon, Olivier; Davison, Adam; Davygora, Yuriy; Dawe, Edmund; Dawson, Ian; Daya-Ishmukhametova, Rozmin; De, Kaushik; de Asmundis, Riccardo; De Castro, Stefano; De Cecco, Sandro; de Graat, Julien; De Groot, Nicolo; de Jong, Paul; De La Taille, Christophe; De la Torre, Hector; De Lorenzi, Francesco; de Mora, Lee; De Nooij, Lucie; De Pedis, Daniele; De Salvo, Alessandro; De Sanctis, Umberto; De Santo, Antonella; De Vivie De Regie, Jean-Baptiste; De Zorzi, Guido; Dearnaley, William James; Debbe, Ramiro; Debenedetti, Chiara; Dechenaux, Benjamin; Dedovich, Dmitri; Degenhardt, James; Del Peso, Jose; Del Prete, Tarcisio; Delemontex, Thomas; Deliyergiyev, Maksym; Dell'Acqua, Andrea; Dell'Asta, Lidia; Della Pietra, Massimo; della Volpe, Domenico; Delmastro, Marco; Delsart, Pierre-Antoine; Deluca, Carolina; Demers, Sarah; Demichev, Mikhail; Demirkoz, Bilge; Denisov, Sergey; Derendarz, Dominik; Derkaoui, Jamal Eddine; Derue, Frederic; Dervan, Paul; Desch, Klaus Kurt; Devetak, Erik; Deviveiros, Pier-Olivier; Dewhurst, Alastair; DeWilde, Burton; Dhaliwal, Saminder; Dhullipudi, Ramasudhakar; Di Ciaccio, Anna; Di Ciaccio, Lucia; Di Donato, Camilla; Di Girolamo, Alessandro; Di Girolamo, Beniamino; Di Luise, Silvestro; Di Mattia, Alessandro; Di Micco, Biagio; Di Nardo, Roberto; Di Simone, Andrea; Di Sipio, Riccardo; Diaz, Marco Aurelio; Diehl, Edward; Dietrich, Janet; Dietzsch, Thorsten; Diglio, Sara; Dindar Yagci, Kamile; Dingfelder, Jochen; Dinut, Florin; Dionisi, Carlo; Dita, Petre; Dita, Sanda; Dittus, Fridolin; Djama, Fares; Djobava, Tamar; Barros do Vale, Maria Aline; Do Valle Wemans, André; Doan, Thi Kieu Oanh; Dobbs, Matt; Dobos, Daniel; Dobson, Ellie; Dodd, Jeremy; Doglioni, Caterina; Doherty, Tom; Doi, Yoshikuni; Dolejsi, Jiri; Dolenc, Irena; Dolezal, Zdenek; Dolgoshein, Boris; Dohmae, Takeshi; Donadelli, Marisilvia; Donini, Julien; Dopke, Jens; Doria, Alessandra; Dos Anjos, Andre; Dotti, Andrea; Dova, Maria-Teresa; Doxiadis, Alexander; Doyle, Tony; Dressnandt, Nandor; Dris, Manolis; Dubbert, Jörg; Dube, Sourabh; Duchovni, Ehud; Duckeck, Guenter; Duda, Dominik; Dudarev, Alexey; Dudziak, Fanny; Dührssen, Michael; Duerdoth, Ian; Duflot, Laurent; Dufour, Marc-Andre; Duguid, Liam; Dunford, Monica; Duran Yildiz, Hatice; Duxfield, Robert; Dwuznik, Michal; Dydak, Friedrich; Düren, Michael; Ebenstein, William; Ebke, Johannes; Eckweiler, Sebastian; Edmonds, Keith; Edson, William; Edwards, Clive; Edwards, Nicholas Charles; Ehrenfeld, Wolfgang; Eifert, Till; Eigen, Gerald; Einsweiler, Kevin; Eisenhandler, Eric; Ekelof, Tord; El Kacimi, Mohamed; Ellert, Mattias; Elles, Sabine; Ellinghaus, Frank; Ellis, Katherine; Ellis, Nicolas; Elmsheuser, Johannes; Elsing, Markus; Emeliyanov, Dmitry; Engelmann, Roderich; Engl, Albert; Epp, Brigitte; Erdmann, Johannes; Ereditato, Antonio; Eriksson, Daniel; Ernst, Jesse; Ernst, Michael; Ernwein, Jean; Errede, Deborah; Errede, Steven; Ertel, Eugen; Escalier, Marc; Esch, Hendrik; Escobar, Carlos; Espinal Curull, Xavier; Esposito, Bellisario; Etienne, Francois; Etienvre, Anne-Isabelle; Etzion, Erez; Evangelakou, Despoina; Evans, Hal; Fabbri, Laura; Fabre, Caroline; Fakhrutdinov, Rinat; Falciano, Speranza; Fang, Yaquan; Fanti, Marcello; Farbin, Amir; Farilla, Addolorata; Farley, Jason; Farooque, Trisha; Farrell, Steven; Farrington, Sinead; Farthouat, Philippe; Fassi, Farida; Fassnacht, Patrick; Fassouliotis, Dimitrios; Fatholahzadeh, Baharak; Favareto, Andrea; Fayard, Louis; Fazio, Salvatore; Febbraro, Renato; Federic, Pavol; Fedin, Oleg; Fedorko, Wojciech; Fehling-Kaschek, Mirjam; Feligioni, Lorenzo; Feng, Cunfeng; Feng, Eric; Fenyuk, Alexander; Ferencei, Jozef; Fernando, Waruna; Ferrag, Samir; Ferrando, James; Ferrara, Valentina; Ferrari, Arnaud; Ferrari, Pamela; Ferrari, Roberto; Ferreira de Lima, Danilo Enoque; Ferrer, Antonio; Ferrere, Didier; Ferretti, Claudio; Ferretto Parodi, Andrea; Fiascaris, Maria; Fiedler, Frank; Filipčič, Andrej; Filthaut, Frank; Fincke-Keeler, Margret; Fiolhais, Miguel; Fiorini, Luca; Firan, Ana; Fischer, Gordon; Fisher, Matthew; Flechl, Martin; Fleck, Ivor; Fleckner, Johanna; Fleischmann, Philipp; Fleischmann, Sebastian; Flick, Tobias; Floderus, Anders; Flores Castillo, Luis; Flowerdew, Michael; Fonseca Martin, Teresa; Formica, Andrea; Forti, Alessandra; Fortin, Dominique; Fournier, Daniel; Fowler, Andrew; Fox, Harald; Francavilla, Paolo; Franchini, Matteo; Franchino, Silvia; Francis, David; Frank, Tal; Franklin, Melissa; Franz, Sebastien; Fraternali, Marco; Fratina, Sasa; French, Sky; Friedrich, Conrad; Friedrich, Felix; Froeschl, Robert; Froidevaux, Daniel; Frost, James; Fukunaga, Chikara; Fullana Torregrosa, Esteban; Fulsom, Bryan Gregory; Fuster, Juan; Gabaldon, Carolina; Gabizon, Ofir; Gadfort, Thomas; Gadomski, Szymon; Gagliardi, Guido; Gagnon, Pauline; Galea, Cristina; Galhardo, Bruno; Gallas, Elizabeth; Gallo, Valentina Santina; Gallop, Bruce; Gallus, Petr; Gan, KK; Gao, Yongsheng; Gaponenko, Andrei; Garberson, Ford; Garcia-Sciveres, Maurice; García, Carmen; García Navarro, José Enrique; Gardner, Robert; Garelli, Nicoletta; Garitaonandia, Hegoi; Garonne, Vincent; Gatti, Claudio; Gaudio, Gabriella; Gaur, Bakul; Gauthier, Lea; Gauzzi, Paolo; Gavrilenko, Igor; Gay, Colin; Gaycken, Goetz; Gazis, Evangelos; Ge, Peng; Gecse, Zoltan; Gee, Norman; Geerts, Daniël Alphonsus Adrianus; Geich-Gimbel, Christoph; Gellerstedt, Karl; Gemme, Claudia; Gemmell, Alistair; Genest, Marie-Hélène; Gentile, Simonetta; George, Matthias; George, Simon; Gerlach, Peter; Gershon, Avi; Geweniger, Christoph; Ghazlane, Hamid; Ghodbane, Nabil; Giacobbe, Benedetto; Giagu, Stefano; Giakoumopoulou, Victoria; Giangiobbe, Vincent; Gianotti, Fabiola; Gibbard, Bruce; Gibson, Adam; Gibson, Stephen; Gilchriese, Murdock; Gillberg, Dag; Gillman, Tony; Gingrich, Douglas; Ginzburg, Jonatan; Giokaris, Nikos; Giordani, MarioPaolo; Giordano, Raffaele; Giorgi, Francesco Michelangelo; Giovannini, Paola; Giraud, Pierre-Francois; Giugni, Danilo; Giunta, Michele; Gjelsten, Børge Kile; Gladilin, Leonid; Glasman, Claudia; Glatzer, Julian; Glazov, Alexandre; Glitza, Karl-Walter; Glonti, George; Goddard, Jack Robert; Godfrey, Jennifer; Godlewski, Jan; Goebel, Martin; Göpfert, Thomas; Goeringer, Christian; Gössling, Claus; Goldfarb, Steven; Golling, Tobias; Gomes, Agostinho; Gomez Fajardo, Luz Stella; Gonçalo, Ricardo; Goncalves Pinto Firmino Da Costa, Joao; Gonella, Laura; González de la Hoz, Santiago; Gonzalez Parra, Garoe; Gonzalez Silva, Laura; Gonzalez-Sevilla, Sergio; Goodson, Jeremiah Jet; Goossens, Luc; Gorbounov, Petr Andreevich; Gordon, Howard; Gorelov, Igor; Gorfine, Grant; Gorini, Benedetto; Gorini, Edoardo; Gorišek, Andrej; Gornicki, Edward; Goshaw, Alfred; Gosselink, Martijn; Gostkin, Mikhail Ivanovitch; Gough Eschrich, Ivo; Gouighri, Mohamed; Goujdami, Driss; Goulette, Marc Phillippe; Goussiou, Anna; Goy, Corinne; Gozpinar, Serdar; Grabowska-Bold, Iwona; Grafström, Per; Grahn, Karl-Johan; Gramstad, Eirik; Grancagnolo, Francesco; Grancagnolo, Sergio; Grassi, Valerio; Gratchev, Vadim; Grau, Nathan; Gray, Heather; Gray, Julia Ann; Graziani, Enrico; Grebenyuk, Oleg; Greenshaw, Timothy; Greenwood, Zeno Dixon; Gregersen, Kristian; Gregor, Ingrid-Maria; Grenier, Philippe; Griffiths, Justin; Grigalashvili, Nugzar; Grillo, Alexander; Grinstein, Sebastian; Gris, Philippe Luc Yves; Grishkevich, Yaroslav; Grivaz, Jean-Francois; Gross, Eilam; Grosse-Knetter, Joern; Groth-Jensen, Jacob; Grybel, Kai; Guest, Daniel; Guicheney, Christophe; Guido, Elisa; Guindon, Stefan; Gul, Umar; Gunther, Jaroslav; Guo, Bin; Guo, Jun; Gutierrez, Phillip; Guttman, Nir; Gutzwiller, Olivier; Guyot, Claude; Gwenlan, Claire; Gwilliam, Carl; Haas, Andy; Haas, Stefan; Haber, Carl; Hadavand, Haleh Khani; Hadley, David; Haefner, Petra; Hahn, Ferdinand; Hajduk, Zbigniew; Hakobyan, Hrachya; Hall, David; Hamacher, Klaus; Hamal, Petr; Hamano, Kenji; Hamer, Matthias; Hamilton, Andrew; Hamilton, Samuel; Han, Liang; Hanagaki, Kazunori; Hanawa, Keita; Hance, Michael; Handel, Carsten; Hanke, Paul; Hansen, John Renner; Hansen, Jørgen Beck; Hansen, Jorn Dines; Hansen, Peter Henrik; Hansson, Per; Hara, Kazuhiko; Harenberg, Torsten; Harkusha, Siarhei; Harper, Devin; Harrington, Robert; Harris, Orin; Hartert, Jochen; Hartjes, Fred; Haruyama, Tomiyoshi; Harvey, Alex; Hasegawa, Satoshi; Hasegawa, Yoji; Hassani, Samira; Haug, Sigve; Hauschild, Michael; Hauser, Reiner; Havranek, Miroslav; Hawkes, Christopher; Hawkings, Richard John; Hawkins, Anthony David; Hayakawa, Takashi; Hayashi, Takayasu; Hayden, Daniel; Hays, Chris; Hayward, Helen; Haywood, Stephen; Head, Simon; Hedberg, Vincent; Heelan, Louise; Heim, Sarah; Heinemann, Beate; Heisterkamp, Simon; Helary, Louis; Heller, Claudio; Heller, Matthieu; Hellman, Sten; Hellmich, Dennis; Helsens, Clement; Henderson, Robert; Henke, Michael; Henrichs, Anna; Henriques Correia, Ana Maria; Henrot-Versille, Sophie; Hensel, Carsten; Henß, Tobias; Medina Hernandez, Carlos; Hernández Jiménez, Yesenia; Herrberg, Ruth; Herten, Gregor; Hertenberger, Ralf; Hervas, Luis; Hesketh, Gavin Grant; Hessey, Nigel; Higón-Rodriguez, Emilio; Hill, John; Hiller, Karl Heinz; Hillert, Sonja; Hillier, Stephen; Hinchliffe, Ian; Hines, Elizabeth; Hirose, Minoru; Hirsch, Florian; Hirschbuehl, Dominic; Hobbs, John; Hod, Noam; Hodgkinson, Mark; Hodgson, Paul; Hoecker, Andreas; Hoeferkamp, Martin; Hoffman, Julia; Hoffmann, Dirk; Hohlfeld, Marc; Holder, Martin; Holmgren, Sven-Olof; Holy, Tomas; Holzbauer, Jenny; Hong, Tae Min; Hooft van Huysduynen, Loek; Horner, Stephan; Hostachy, Jean-Yves; Hou, Suen; Hoummada, Abdeslam; Howard, Jacob; Howarth, James; Hristova, Ivana; Hrivnac, Julius; Hryn'ova, Tetiana; Hsu, Pai-hsien Jennifer; Hsu, Shih-Chieh; Hu, Diedi; Hubacek, Zdenek; Hubaut, Fabrice; Huegging, Fabian; Huettmann, Antje; Huffman, Todd Brian; Hughes, Emlyn; Hughes, Gareth; Huhtinen, Mika; Hurwitz, Martina; Huseynov, Nazim; Huston, Joey; Huth, John; Iacobucci, Giuseppe; Iakovidis, Georgios; Ibbotson, Michael; Ibragimov, Iskander; Iconomidou-Fayard, Lydia; Idarraga, John; Iengo, Paolo; Igonkina, Olga; Ikegami, Yoichi; Ikeno, Masahiro; Iliadis, Dimitrios; Ilic, Nikolina; Ince, Tayfun; Inigo-Golfin, Joaquin; Ioannou, Pavlos; Iodice, Mauro; Iordanidou, Kalliopi; Ippolito, Valerio; Irles Quiles, Adrian; Isaksson, Charlie; Ishino, Masaya; Ishitsuka, Masaki; Ishmukhametov, Renat; Issever, Cigdem; Istin, Serhat; Ivashin, Anton; Iwanski, Wieslaw; Iwasaki, Hiroyuki; Izen, Joseph; Izzo, Vincenzo; Jackson, Brett; Jackson, John; Jackson, Paul; Jaekel, Martin; Jain, Vivek; Jakobs, Karl; Jakobsen, Sune; Jakoubek, Tomas; Jakubek, Jan; Jamin, David Olivier; Jana, Dilip; Jansen, Eric; Jansen, Hendrik; Janssen, Jens; Jantsch, Andreas; Janus, Michel; Jared, Richard; Jarlskog, Göran; Jeanty, Laura; Jen-La Plante, Imai; Jennens, David; Jenni, Peter; Loevschall-Jensen, Ask Emil; Jež, Pavel; Jézéquel, Stéphane; Jha, Manoj Kumar; Ji, Haoshuang; Ji, Weina; Jia, Jiangyong; Jiang, Yi; Jimenez Belenguer, Marcos; Jin, Shan; Jinnouchi, Osamu; Joergensen, Morten Dam; Joffe, David; Johansen, Marianne; Johansson, Erik; Johansson, Per; Johnert, Sebastian; Johns, Kenneth; Jon-And, Kerstin; Jones, Graham; Jones, Roger; Jones, Tim; Joram, Christian; Jorge, Pedro; Joshi, Kiran Daniel; Jovicevic, Jelena; Jovin, Tatjana; Ju, Xiangyang; Jung, Christian; Jungst, Ralph Markus; Juranek, Vojtech; Jussel, Patrick; Juste Rozas, Aurelio; Kabana, Sonja; Kaci, Mohammed; Kaczmarska, Anna; Kadlecik, Peter; Kado, Marumi; Kagan, Harris; Kagan, Michael; Kajomovitz, Enrique; Kalinin, Sergey; Kalinovskaya, Lidia; Kama, Sami; Kanaya, Naoko; Kaneda, Michiru; Kaneti, Steven; Kanno, Takayuki; Kantserov, Vadim; Kanzaki, Junichi; Kaplan, Benjamin; Kapliy, Anton; Kaplon, Jan; Kar, Deepak; Karagounis, Michael; Karakostas, Konstantinos; Karnevskiy, Mikhail; Kartvelishvili, Vakhtang; Karyukhin, Andrey; Kashif, Lashkar; Kasieczka, Gregor; Kass, Richard; Kastanas, Alex; Kataoka, Mayuko; Kataoka, Yousuke; Katsoufis, Elias; Katzy, Judith; Kaushik, Venkatesh; Kawagoe, Kiyotomo; Kawamoto, Tatsuo; Kawamura, Gen; Kayl, Manuel; Kazama, Shingo; Kazanin, Vassili; Kazarinov, Makhail; Keeler, Richard; Keener, Paul; Kehoe, Robert; Keil, Markus; Kekelidze, George; Keller, John; Kenyon, Mike; Kepka, Oldrich; Kerschen, Nicolas; Kerševan, Borut Paul; Kersten, Susanne; Kessoku, Kohei; Keung, Justin; Khalil-zada, Farkhad; Khandanyan, Hovhannes; Khanov, Alexander; Kharchenko, Dmitri; Khodinov, Alexander; Khomich, Andrei; Khoo, Teng Jian; Khoriauli, Gia; Khoroshilov, Andrey; Khovanskiy, Valery; Khramov, Evgeniy; Khubua, Jemal; Kim, Hyeon Jin; Kim, Shinhong; Kimura, Naoki; Kind, Oliver; King, Barry; King, Matthew; King, Robert Steven Beaufoy; Kirk, Julie; Kiryunin, Andrey; Kishimoto, Tomoe; Kisielewska, Danuta; Kitamura, Takumi; Kittelmann, Thomas; Kiuchi, Kenji; Kladiva, Eduard; Klein, Max; Klein, Uta; Kleinknecht, Konrad; Klemetti, Miika; Klier, Amit; Klimek, Pawel; Klimentov, Alexei; Klingenberg, Reiner; Klinger, Joel Alexander; Klinkby, Esben; Klioutchnikova, Tatiana; Klok, Peter; Klous, Sander; Kluge, Eike-Erik; Kluge, Thomas; Kluit, Peter; Kluth, Stefan; Kneringer, Emmerich; Knoops, Edith; Knue, Andrea; Ko, Byeong Rok; Kobayashi, Tomio; Kobel, Michael; Kocian, Martin; Kodys, Peter; Köneke, Karsten; König, Adriaan; Koenig, Sebastian; Köpke, Lutz; Koetsveld, Folkert; Koevesarki, Peter; Koffas, Thomas; Koffeman, Els; Kogan, Lucy Anne; Kohlmann, Simon; Kohn, Fabian; Kohout, Zdenek; Kohriki, Takashi; Koi, Tatsumi; Kolachev, Guennady; Kolanoski, Hermann; Kolesnikov, Vladimir; Koletsou, Iro; Koll, James; Komar, Aston; Komori, Yuto; Kondo, Takahiko; Kono, Takanori; Kononov, Anatoly; Konoplich, Rostislav; Konstantinidis, Nikolaos; Kopeliansky, Revital; Koperny, Stefan; Korcyl, Krzysztof; Kordas, Kostantinos; Korn, Andreas; Korol, Aleksandr; Korolkov, Ilya; Korolkova, Elena; Korotkov, Vladislav; Kortner, Oliver; Kortner, Sandra; Kostyukhin, Vadim; Kotov, Sergey; Kotov, Vladislav; Kotwal, Ashutosh; Kourkoumelis, Christine; Kouskoura, Vasiliki; Koutsman, Alex; Kowalewski, Robert Victor; Kowalski, Tadeusz; Kozanecki, Witold; Kozhin, Anatoly; Kral, Vlastimil; Kramarenko, Viktor; Kramberger, Gregor; Krasny, Mieczyslaw Witold; Krasznahorkay, Attila; Kraus, Jana; Kreiss, Sven; Krejci, Frantisek; Kretzschmar, Jan; Krieger, Nina; Krieger, Peter; Kroeninger, Kevin; Kroha, Hubert; Kroll, Joe; Kroseberg, Juergen; Krstic, Jelena; Kruchonak, Uladzimir; Krüger, Hans; Kruker, Tobias; Krumnack, Nils; Krumshteyn, Zinovii; Kruse, Mark; Kubota, Takashi; Kuday, Sinan; Kuehn, Susanne; Kugel, Andreas; Kuhl, Thorsten; Kuhn, Dietmar; Kukhtin, Victor; Kulchitsky, Yuri; Kuleshov, Sergey; Kummer, Christian; Kuna, Marine; Kunkle, Joshua; Kupco, Alexander; Kurashige, Hisaya; Kurata, Masakazu; Kurochkin, Yurii; Kus, Vlastimil; Kuwertz, Emma Sian; Kuze, Masahiro; Kvita, Jiri; Kwee, Regina; La Rosa, Alessandro; La Rotonda, Laura; Labarga, Luis; Labbe, Julien; Lablak, Said; Lacasta, Carlos; Lacava, Francesco; Lacey, James; Lacker, Heiko; Lacour, Didier; Lacuesta, Vicente Ramón; Ladygin, Evgueni; Lafaye, Remi; Laforge, Bertrand; Lagouri, Theodota; Lai, Stanley; Laisne, Emmanuel; Lambourne, Luke; Lampen, Caleb; Lampl, Walter; Lancon, Eric; Landgraf, Ulrich; Landon, Murrough; Lang, Valerie Susanne; Lange, Clemens; Lankford, Andrew; Lanni, Francesco; Lantzsch, Kerstin; Lanza, Agostino; Laplace, Sandrine; Lapoire, Cecile; Laporte, Jean-Francois; Lari, Tommaso; Larner, Aimee; Lassnig, Mario; Laurelli, Paolo; Lavorini, Vincenzo; Lavrijsen, Wim; Laycock, Paul; Le Dortz, Olivier; Le Guirriec, Emmanuel; Le Menedeu, Eve; LeCompte, Thomas; Ledroit-Guillon, Fabienne Agnes Marie; Lee, Hurng-Chun; Lee, Jason; Lee, Shih-Chang; Lee, Lawrence; Lefebvre, Michel; Legendre, Marie; Legger, Federica; Leggett, Charles; Lehmacher, Marc; Lehmann Miotto, Giovanna; Leister, Andrew Gerard; Leite, Marco Aurelio Lisboa; Leitner, Rupert; Lellouch, Daniel; Lemmer, Boris; Lendermann, Victor; Leney, Katharine; Lenz, Tatiana; Lenzen, Georg; Lenzi, Bruno; Leonhardt, Kathrin; Leontsinis, Stefanos; Lepold, Florian; Leroy, Claude; Lessard, Jean-Raphael; Lester, Christopher; Lester, Christopher Michael; Levêque, Jessica; Levin, Daniel; Levinson, Lorne; Lewis, Adrian; Lewis, George; Leyko, Agnieszka; Leyton, Michael; Li, Bo; Li, Haifeng; Li, Ho Ling; Li, Shu; Li, Xuefei; Liang, Zhijun; Liao, Hongbo; Liberti, Barbara; Lichard, Peter; Lichtnecker, Markus; Lie, Ki; Liebig, Wolfgang; Limbach, Christian; Limosani, Antonio; Limper, Maaike; Lin, Simon; Linde, Frank; Linnemann, James; Lipeles, Elliot; Lipniacka, Anna; Liss, Tony; Lissauer, David; Lister, Alison; Litke, Alan; Liu, Chuanlei; Liu, Dong; Liu, Hao; Liu, Jianbei; Liu, Lulu; Liu, Minghui; Liu, Yanwen; Livan, Michele; Livermore, Sarah; Lleres, Annick; Llorente Merino, Javier; Lloyd, Stephen; Lobodzinska, Ewelina; Loch, Peter; Lockman, William; Loddenkoetter, Thomas; Loebinger, Fred; Loginov, Andrey; Loh, Chang Wei; Lohse, Thomas; Lohwasser, Kristin; Lokajicek, Milos; Lombardo, Vincenzo Paolo; Long, Robin Eamonn; Lopes, Lourenco; Lopez Mateos, David; Lorenz, Jeanette; Lorenzo Martinez, Narei; Losada, Marta; Loscutoff, Peter; Lo Sterzo, Francesco; Losty, Michael; Lou, XinChou; Lounis, Abdenour; Loureiro, Karina; Love, Jeremy; Love, Peter; Lowe, Andrew; Lu, Feng; Lubatti, Henry; Luci, Claudio; Lucotte, Arnaud; Ludwig, Andreas; Ludwig, Dörthe; Ludwig, Inga; Ludwig, Jens; Luehring, Frederick; Luijckx, Guy; Lukas, Wolfgang; Luminari, Lamberto; Lund, Esben; Lund-Jensen, Bengt; Lundberg, Björn; Lundberg, Johan; Lundberg, Olof; Lundquist, Johan; Lungwitz, Matthias; Lynn, David; Lytken, Else; Ma, Hong; Ma, Lian Liang; Maccarrone, Giovanni; Macchiolo, Anna; Maček, Boštjan; Machado Miguens, Joana; Macina, Daniela; Mackeprang, Rasmus; Madaras, Ronald; Maddocks, Harvey Jonathan; Mader, Wolfgang; Maenner, Reinhard; Maeno, Tadashi; Mättig, Peter; Mättig, Stefan; Magnoni, Luca; Magradze, Erekle; Mahboubi, Kambiz; Mahlstedt, Joern; Mahmoud, Sara; Mahout, Gilles; Maiani, Camilla; Maidantchik, Carmen; Maio, Amélia; Majewski, Stephanie; Makida, Yasuhiro; Makovec, Nikola; Mal, Prolay; Malaescu, Bogdan; Malecki, Pawel; Malecki, Piotr; Maleev, Victor; Malek, Fairouz; Mallik, Usha; Malon, David; Malone, Caitlin; Maltezos, Stavros; Malyshev, Vladimir; Malyukov, Sergei; Mameghani, Raphael; Mamuzic, Judita; Manabe, Atsushi; Mandelli, Luciano; Mandić, Igor; Mandrysch, Rocco; Maneira, José; Manfredini, Alessandro; Manhaes de Andrade Filho, Luciano; Manjarres Ramos, Joany Andreina; Mann, Alexander; Manning, Peter; Manousakis-Katsikakis, Arkadios; Mansoulie, Bruno; Mapelli, Alessandro; Mapelli, Livio; March, Luis; Marchand, Jean-Francois; Marchese, Fabrizio; Marchiori, Giovanni; Marcisovsky, Michal; Marino, Christopher; Marroquim, Fernando; Marshall, Zach; Martens, Kalen; Marti, Lukas Fritz; Marti-Garcia, Salvador; Martin, Brian; Martin, Brian Thomas; Martin, Jean-Pierre; Martin, Tim; Martin, Victoria Jane; Martin dit Latour, Bertrand; Martin-Haugh, Stewart; Martinez, Mario; Martinez Outschoorn, Verena; Martyniuk, Alex; Marx, Marilyn; Marzano, Francesco; Marzin, Antoine; Masetti, Lucia; Mashimo, Tetsuro; Mashinistov, Ruslan; Masik, Jiri; Maslennikov, Alexey; Massa, Ignazio; Massaro, Graziano; Massol, Nicolas; Mastrandrea, Paolo; Mastroberardino, Anna; Masubuchi, Tatsuya; Matricon, Pierre; Matsunaga, Hiroyuki; Matsushita, Takashi; Mattravers, Carly; Maurer, Julien; Maxfield, Stephen; Maximov, Dmitriy; Mayne, Anna; Mazini, Rachid; Mazur, Michael; Mazzaferro, Luca; Mazzanti, Marcello; Mc Donald, Jeffrey; Mc Kee, Shawn Patrick; McCarn, Allison; McCarthy, Robert; McCarthy, Tom; McCubbin, Norman; McFarlane, Kenneth; Mcfayden, Josh; Mchedlidze, Gvantsa; Mclaughlan, Tom; McMahon, Steve; McPherson, Robert; Meade, Andrew; Mechnich, Joerg; Mechtel, Markus; Medinnis, Mike; Meehan, Samuel; Meera-Lebbai, Razzak; Meguro, Tatsuma; Mehlhase, Sascha; Mehta, Andrew; Meier, Karlheinz; Meirose, Bernhard; Melachrinos, Constantinos; Mellado Garcia, Bruce Rafael; Meloni, Federico; Mendoza Navas, Luis; Meng, Zhaoxia; Mengarelli, Alberto; Menke, Sven; Meoni, Evelin; Mercurio, Kevin Michael; Mermod, Philippe; Merola, Leonardo; Meroni, Chiara; Merritt, Frank; Merritt, Hayes; Messina, Andrea; Metcalfe, Jessica; Mete, Alaettin Serhan; Meyer, Carsten; Meyer, Christopher; Meyer, Jean-Pierre; Meyer, Jochen; Meyer, Joerg; Michal, Sebastien; Micu, Liliana; Middleton, Robin; Migas, Sylwia; Mijović, Liza; Mikenberg, Giora; Mikestikova, Marcela; Mikuž, Marko; Miller, David; Miller, Robert; Mills, Bill; Mills, Corrinne; Milov, Alexander; Milstead, David; Milstein, Dmitry; Minaenko, Andrey; Miñano Moya, Mercedes; Minashvili, Irakli; Mincer, Allen; Mindur, Bartosz; Mineev, Mikhail; Ming, Yao; Mir, Lluisa-Maria; Mirabelli, Giovanni; Mitrevski, Jovan; Mitsou, Vasiliki A; Mitsui, Shingo; Miyagawa, Paul; Mjörnmark, Jan-Ulf; Moa, Torbjoern; Moeller, Victoria; Mönig, Klaus; Möser, Nicolas; Mohapatra, Soumya; Mohr, Wolfgang; Moles-Valls, Regina; Molfetas, Angelos; Monk, James; Monnier, Emmanuel; Montejo Berlingen, Javier; Monticelli, Fernando; Monzani, Simone; Moore, Roger; Moorhead, Gareth; Mora Herrera, Clemencia; Moraes, Arthur; Morange, Nicolas; Morel, Julien; Morello, Gianfranco; Moreno, Deywis; Moreno Llácer, María; Morettini, Paolo; Morgenstern, Marcus; Morii, Masahiro; Morley, Anthony Keith; Mornacchi, Giuseppe; Morris, John; Morvaj, Ljiljana; Moser, Hans-Guenther; Mosidze, Maia; Moss, Josh; Mount, Richard; Mountricha, Eleni; Mouraviev, Sergei; Moyse, Edward; Mueller, Felix; Mueller, James; Mueller, Klemens; Müller, Thomas; Mueller, Timo; Muenstermann, Daniel; Munwes, Yonathan; Murray, Bill; Mussche, Ido; Musto, Elisa; Myagkov, Alexey; Myska, Miroslav; Nackenhorst, Olaf; Nadal, Jordi; Nagai, Koichi; Nagai, Ryo; Nagano, Kunihiro; Nagarkar, Advait; Nagasaka, Yasushi; Nagel, Martin; Nairz, Armin Michael; Nakahama, Yu; Nakamura, Koji; Nakamura, Tomoaki; Nakano, Itsuo; Nanava, Gizo; Napier, Austin; Narayan, Rohin; Nash, Michael; Nattermann, Till; Naumann, Thomas; Navarro, Gabriela; Neal, Homer; Nechaeva, Polina; Neep, Thomas James; Negri, Andrea; Negri, Guido; Negrini, Matteo; Nektarijevic, Snezana; Nelson, Andrew; Nelson, Timothy Knight; Nemecek, Stanislav; Nemethy, Peter; Nepomuceno, Andre Asevedo; Nessi, Marzio; Neubauer, Mark; Neumann, Manuel; Neusiedl, Andrea; Neves, Ricardo; Nevski, Pavel; Newcomer, Mitchel; Newman, Paul; Nguyen Thi Hong, Van; Nickerson, Richard; Nicolaidou, Rosy; Nicquevert, Bertrand; Niedercorn, Francois; Nielsen, Jason; Nikiforou, Nikiforos; Nikiforov, Andriy; Nikolaenko, Vladimir; Nikolic-Audit, Irena; Nikolics, Katalin; Nikolopoulos, Konstantinos; Nilsen, Henrik; Nilsson, Paul; Ninomiya, Yoichi; Nisati, Aleandro; Nisius, Richard; Nobe, Takuya; Nodulman, Lawrence; Nomachi, Masaharu; Nomidis, Ioannis; Norberg, Scarlet; Nordberg, Markus; Norton, Peter; Novakova, Jana; Nozaki, Mitsuaki; Nozka, Libor; Nugent, Ian Michael; Nuncio-Quiroz, Adriana-Elizabeth; Nunes Hanninger, Guilherme; Nunnemann, Thomas; Nurse, Emily; O'Brien, Brendan Joseph; O'Neil, Dugan; O'Shea, Val; Oakes, Louise Beth; Oakham, Gerald; Oberlack, Horst; Ocariz, Jose; Ochi, Atsuhiko; Oda, Susumu; Odaka, Shigeru; Odier, Jerome; Ogren, Harold; Oh, Alexander; Oh, Seog; Ohm, Christian; Ohshima, Takayoshi; Okamura, Wataru; Okawa, Hideki; Okumura, Yasuyuki; Okuyama, Toyonobu; Olariu, Albert; Olchevski, Alexander; Olivares Pino, Sebastian Andres; Oliveira, Miguel Alfonso; Oliveira Damazio, Denis; Oliver Garcia, Elena; Olivito, Dominick; Olszewski, Andrzej; Olszowska, Jolanta; Onofre, António; Onyisi, Peter; Oram, Christopher; Oreglia, Mark; Oren, Yona; Orestano, Domizia; Orlando, Nicola; Orlov, Iliya; Oropeza Barrera, Cristina; Orr, Robert; Osculati, Bianca; Ospanov, Rustem; Osuna, Carlos; Otero y Garzon, Gustavo; Ottersbach, John; Ouchrif, Mohamed; Ouellette, Eric; Ould-Saada, Farid; Ouraou, Ahmimed; Ouyang, Qun; Ovcharova, Ana; Owen, Mark; Owen, Simon; Ozcan, Veysi Erkcan; Ozturk, Nurcan; Pacheco Pages, Andres; Padilla Aranda, Cristobal; Pagan Griso, Simone; Paganis, Efstathios; Pahl, Christoph; Paige, Frank; Pais, Preema; Pajchel, Katarina; Palacino, Gabriel; Paleari, Chiara; Palestini, Sandro; Pallin, Dominique; Palma, Alberto; Palmer, Jody; Pan, Yibin; Panagiotopoulou, Evgenia; Panduro Vazquez, William; Pani, Priscilla; Panikashvili, Natalia; Panitkin, Sergey; Pantea, Dan; Papadelis, Aras; Papadopoulou, Theodora; Paramonov, Alexander; Paredes Hernandez, Daniela; Park, Woochun; Parker, Michael Andrew; Parodi, Fabrizio; Parsons, John; Parzefall, Ulrich; Pashapour, Shabnaz; Pasqualucci, Enrico; Passaggio, Stefano; Passeri, Antonio; Pastore, Fernanda; Pastore, Francesca; Pásztor, Gabriella; Pataraia, Sophio; Patel, Nikhul; Pater, Joleen; Patricelli, Sergio; Pauly, Thilo; Pecsy, Martin; Pedraza Lopez, Sebastian; Pedraza Morales, Maria Isabel; Peleganchuk, Sergey; Pelikan, Daniel; Peng, Haiping; Penning, Bjoern; Penson, Alexander; Penwell, John; Perantoni, Marcelo; Perez, Kerstin; Perez Cavalcanti, Tiago; Perez Codina, Estel; Pérez García-Estañ, María Teresa; Perez Reale, Valeria; Perini, Laura; Pernegger, Heinz; Perrino, Roberto; Perrodo, Pascal; Peshekhonov, Vladimir; Peters, Krisztian; Petersen, Brian; Petersen, Jorgen; Petersen, Troels; Petit, Elisabeth; Petridis, Andreas; Petridou, Chariclia; Petrolo, Emilio; Petrucci, Fabrizio; Petschull, Dennis; Petteni, Michele; Pezoa, Raquel; Phan, Anna; Phillips, Peter William; Piacquadio, Giacinto; Picazio, Attilio; Piccaro, Elisa; Piccinini, Maurizio; Piec, Sebastian Marcin; Piegaia, Ricardo; Pignotti, David; Pilcher, James; Pilkington, Andrew; Pina, João Antonio; Pinamonti, Michele; Pinder, Alex; Pinfold, James; Pinto, Belmiro; Pizio, Caterina; Plamondon, Mathieu; Pleier, Marc-Andre; Plotnikova, Elena; Poblaguev, Andrei; Poddar, Sahill; Podlyski, Fabrice; Poggioli, Luc; Pohl, David-leon; Pohl, Martin; Polesello, Giacomo; Policicchio, Antonio; Polini, Alessandro; Poll, James; Polychronakos, Venetios; Pomeroy, Daniel; Pommès, Kathy; Pontecorvo, Ludovico; Pope, Bernard; Popeneciu, Gabriel Alexandru; Popovic, Dragan; Poppleton, Alan; Portell Bueso, Xavier; Pospelov, Guennady; Pospisil, Stanislav; Potrap, Igor; Potter, Christina; Potter, Christopher; Poulard, Gilbert; Poveda, Joaquin; Pozdnyakov, Valery; Prabhu, Robindra; Pralavorio, Pascal; Pranko, Aliaksandr; Prasad, Srivas; Pravahan, Rishiraj; Prell, Soeren; Pretzl, Klaus Peter; Price, Darren; Price, Joe; Price, Lawrence; Prieur, Damien; Primavera, Margherita; Prokofiev, Kirill; Prokoshin, Fedor; Protopopescu, Serban; Proudfoot, James; Prudent, Xavier; Przybycien, Mariusz; Przysiezniak, Helenka; Psoroulas, Serena; Ptacek, Elizabeth; Pueschel, Elisa; Purdham, John; Purohit, Milind; Puzo, Patrick; Pylypchenko, Yuriy; Qian, Jianming; Quadt, Arnulf; Quarrie, David; Quayle, William; Quinonez, Fernando; Raas, Marcel; Radeka, Veljko; Radescu, Voica; Radloff, Peter; Rador, Tonguc; Ragusa, Francesco; Rahal, Ghita; Rahimi, Amir; Rahm, David; Rajagopalan, Srinivasan; Rammensee, Michael; Rammes, Marcus; Randle-Conde, Aidan Sean; Randrianarivony, Koloina; Rauscher, Felix; Rave, Tobias Christian; Raymond, Michel; Read, Alexander Lincoln; Rebuzzi, Daniela; Redelbach, Andreas; Redlinger, George; Reece, Ryan; Reeves, Kendall; Reinsch, Andreas; Reisinger, Ingo; Rembser, Christoph; Ren, Zhongliang; Renaud, Adrien; Rescigno, Marco; Resconi, Silvia; Resende, Bernardo; Reznicek, Pavel; Rezvani, Reyhaneh; Richter, Robert; Richter-Was, Elzbieta; Ridel, Melissa; Rijpstra, Manouk; Rijssenbeek, Michael; Rimoldi, Adele; Rinaldi, Lorenzo; Rios, Ryan Randy; Riu, Imma; Rivoltella, Giancesare; Rizatdinova, Flera; Rizvi, Eram; Robertson, Steven; Robichaud-Veronneau, Andree; Robinson, Dave; Robinson, James; Robson, Aidan; Rocha de Lima, Jose Guilherme; Roda, Chiara; Roda Dos Santos, Denis; Roe, Adam; Roe, Shaun; Røhne, Ole; Rolli, Simona; Romaniouk, Anatoli; Romano, Marino; Romeo, Gaston; Romero Adam, Elena; Rompotis, Nikolaos; Roos, Lydia; Ros, Eduardo; Rosati, Stefano; Rosbach, Kilian; Rose, Anthony; Rose, Matthew; Rosenbaum, Gabriel; Rosenberg, Eli; Rosendahl, Peter Lundgaard; Rosenthal, Oliver; Rosselet, Laurent; Rossetti, Valerio; Rossi, Elvira; Rossi, Leonardo Paolo; Rotaru, Marina; Roth, Itamar; Rothberg, Joseph; Rousseau, David; Royon, Christophe; Rozanov, Alexandre; Rozen, Yoram; Ruan, Xifeng; Rubbo, Francesco; Rubinskiy, Igor; Ruckstuhl, Nicole; Rud, Viacheslav; Rudolph, Christian; Rudolph, Gerald; Rühr, Frederik; Ruiz-Martinez, Aranzazu; Rumyantsev, Leonid; Rurikova, Zuzana; Rusakovich, Nikolai; Ruschke, Alexander; Rutherfoord, John; Ruzicka, Pavel; Ryabov, Yury; Rybar, Martin; Rybkin, Grigori; Ryder, Nick; Saavedra, Aldo; Sadeh, Iftach; Sadrozinski, Hartmut; Sadykov, Renat; Safai Tehrani, Francesco; Sakamoto, Hiroshi; Salamanna, Giuseppe; Salamon, Andrea; Saleem, Muhammad; Salek, David; Salihagic, Denis; Salnikov, Andrei; Salt, José; Salvachua Ferrando, Belén; Salvatore, Daniela; Salvatore, Pasquale Fabrizio; Salvucci, Antonio; Salzburger, Andreas; Sampsonidis, Dimitrios; Samset, Björn Hallvard; Sanchez, Arturo; Sanchez Martinez, Victoria; Sandaker, Heidi; Sander, Heinz Georg; Sanders, Michiel; Sandhoff, Marisa; Sandoval, Tanya; Sandoval, Carlos; Sandstroem, Rikard; Sankey, Dave; Sansoni, Andrea; Santamarina Rios, Cibran; Santoni, Claudio; Santonico, Rinaldo; Santos, Helena; Santoyo Castillo, Itzebelt; Saraiva, João; Sarangi, Tapas; Sarkisyan-Grinbaum, Edward; Sarrazin, Bjorn; Sarri, Francesca; Sartisohn, Georg; Sasaki, Osamu; Sasaki, Yuichi; Sasao, Noboru; Satsounkevitch, Igor; Sauvage, Gilles; Sauvan, Emmanuel; Sauvan, Jean-Baptiste; Savard, Pierre; Savinov, Vladimir; Savu, Dan Octavian; Sawyer, Lee; Saxon, David; Saxon, James; Sbarra, Carla; Sbrizzi, Antonio; Scannicchio, Diana; Scarcella, Mark; Schaarschmidt, Jana; Schacht, Peter; Schaefer, Douglas; Schäfer, Uli; Schaelicke, Andreas; Schaepe, Steffen; Schaetzel, Sebastian; Schaffer, Arthur; Schaile, Dorothee; Schamberger, R. Dean; Schamov, Andrey; Scharf, Veit; Schegelsky, Valery; Scheirich, Daniel; Schernau, Michael; Scherzer, Max; Schiavi, Carlo; Schieck, Jochen; Schioppa, Marco; Schlenker, Stefan; Schmidt, Evelyn; Schmieden, Kristof; Schmitt, Christian; Schmitt, Sebastian; Schneider, Basil; Schnoor, Ulrike; Schoeffel, Laurent; Schoening, Andre; Schorlemmer, Andre Lukas; Schott, Matthias; Schouten, Doug; Schovancova, Jaroslava; Schram, Malachi; Schroeder, Christian; Schroer, Nicolai; Schultens, Martin Johannes; Schultes, Joachim; Schultz-Coulon, Hans-Christian; Schulz, Holger; Schumacher, Markus; Schumm, Bruce; Schune, Philippe; Schwanenberger, Christian; Schwartzman, Ariel; Schwegler, Philipp; Schwemling, Philippe; Schwienhorst, Reinhard; Schwierz, Rainer; Schwindling, Jerome; Schwindt, Thomas; Schwoerer, Maud; Sciacca, Gianfranco; Sciolla, Gabriella; Scott, Bill; Searcy, Jacob; Sedov, George; Sedykh, Evgeny; Seidel, Sally; Seiden, Abraham; Seifert, Frank; Seixas, José; Sekhniaidze, Givi; Sekula, Stephen; Selbach, Karoline Elfriede; Seliverstov, Dmitry; Sellden, Bjoern; Sellers, Graham; Seman, Michal; Semprini-Cesari, Nicola; Serfon, Cedric; Serin, Laurent; Serkin, Leonid; Seuster, Rolf; Severini, Horst; Sfyrla, Anna; Shabalina, Elizaveta; Shamim, Mansoora; Shan, Lianyou; Shank, James; Shao, Qi Tao; Shapiro, Marjorie; Shatalov, Pavel; Shaw, Kate; Sherman, Daniel; Sherwood, Peter; Shimizu, Shima; Shimojima, Makoto; Shin, Taeksu; Shiyakova, Mariya; Shmeleva, Alevtina; Shochet, Mel; Short, Daniel; Shrestha, Suyog; Shulga, Evgeny; Shupe, Michael; Sicho, Petr; Sidoti, Antonio; Siegert, Frank; Sijacki, Djordje; Silbert, Ohad; Silva, José; Silver, Yiftah; Silverstein, Daniel; Silverstein, Samuel; Simak, Vladislav; Simard, Olivier; Simic, Ljiljana; Simion, Stefan; Simioni, Eduard; Simmons, Brinick; Simoniello, Rosa; Simonyan, Margar; Sinervo, Pekka; Sinev, Nikolai; Sipica, Valentin; Siragusa, Giovanni; Sircar, Anirvan; Sisakyan, Alexei; Sivoklokov, Serguei; Sjölin, Jörgen; Sjursen, Therese; Skinnari, Louise Anastasia; Skottowe, Hugh Philip; Skovpen, Kirill; Skubic, Patrick; Slater, Mark; Slavicek, Tomas; Sliwa, Krzysztof; Smakhtin, Vladimir; Smart, Ben; Smestad, Lillian; Smirnov, Sergei; Smirnov, Yury; Smirnova, Lidia; Smirnova, Oxana; Smith, Ben Campbell; Smith, Douglas; Smith, Kenway; Smizanska, Maria; Smolek, Karel; Snesarev, Andrei; Snow, Steve; Snow, Joel; Snyder, Scott; Sobie, Randall; Sodomka, Jaromir; Soffer, Abner; Solans, Carlos; Solar, Michael; Solc, Jaroslav; Soldatov, Evgeny; Soldevila, Urmila; Solfaroli Camillocci, Elena; Solodkov, Alexander; Solovyanov, Oleg; Solovyev, Victor; Soni, Nitesh; Sopko, Vit; Sopko, Bruno; Sosebee, Mark; Soualah, Rachik; Soukharev, Andrey; Spagnolo, Stefania; Spanò, Francesco; Spighi, Roberto; Spigo, Giancarlo; Spiwoks, Ralf; Spousta, Martin; Spreitzer, Teresa; Spurlock, Barry; St Denis, Richard Dante; Stahlman, Jonathan; Stamen, Rainer; Stanecka, Ewa; Stanek, Robert; Stanescu, Cristian; Stanescu-Bellu, Madalina; Stanitzki, Marcel Michael; Stapnes, Steinar; Starchenko, Evgeny; Stark, Jan; Staroba, Pavel; Starovoitov, Pavel; Staszewski, Rafal; Staude, Arnold; Stavina, Pavel; Steele, Genevieve; Steinbach, Peter; Steinberg, Peter; Stekl, Ivan; Stelzer, Bernd; Stelzer, Harald Joerg; Stelzer-Chilton, Oliver; Stenzel, Hasko; Stern, Sebastian; Stewart, Graeme; Stillings, Jan Andre; Stockton, Mark; Stoerig, Kathrin; Stoicea, Gabriel; Stonjek, Stefan; Strachota, Pavel; Stradling, Alden; Straessner, Arno; Strandberg, Jonas; Strandberg, Sara; Strandlie, Are; Strang, Michael; Strauss, Emanuel; Strauss, Michael; Strizenec, Pavol; Ströhmer, Raimund; Strom, David; Strong, John; Stroynowski, Ryszard; Stugu, Bjarne; Stumer, Iuliu; Stupak, John; Sturm, Philipp; Styles, Nicholas Adam; Soh, Dart-yin; Su, Dong; Subramania, Halasya Siva; Subramaniam, Rajivalochan; Succurro, Antonella; Sugaya, Yorihito; Suhr, Chad; Suk, Michal; Sulin, Vladimir; Sultansoy, Saleh; Sumida, Toshi; Sun, Xiaohu; Sundermann, Jan Erik; Suruliz, Kerim; Susinno, Giancarlo; Sutton, Mark; Suzuki, Yu; Suzuki, Yuta; Svatos, Michal; Swedish, Stephen; Sykora, Ivan; Sykora, Tomas; Sánchez, Javier; Ta, Duc; Tackmann, Kerstin; Taffard, Anyes; Tafirout, Reda; Taiblum, Nimrod; Takahashi, Yuta; Takai, Helio; Takashima, Ryuichi; Takeda, Hiroshi; Takeshita, Tohru; Takubo, Yosuke; Talby, Mossadek; Talyshev, Alexey; Tamsett, Matthew; Tan, Kong Guan; Tanaka, Junichi; Tanaka, Reisaburo; Tanaka, Satoshi; Tanaka, Shuji; Tanasijczuk, Andres Jorge; Tani, Kazutoshi; Tannoury, Nancy; Tapprogge, Stefan; Tardif, Dominique; Tarem, Shlomit; Tarrade, Fabien; Tartarelli, Giuseppe Francesco; Tas, Petr; Tasevsky, Marek; Tassi, Enrico; Tayalati, Yahya; Taylor, Christopher; Taylor, Frank; Taylor, Geoffrey; Taylor, Wendy; Teinturier, Marthe; Teischinger, Florian Alfred; Teixeira Dias Castanheira, Matilde; Teixeira-Dias, Pedro; Temming, Kim Katrin; Ten Kate, Herman; Teng, Ping-Kun; Terada, Susumu; Terashi, Koji; Terron, Juan; Testa, Marianna; Teuscher, Richard; Therhaag, Jan; Theveneaux-Pelzer, Timothée; Thoma, Sascha; Thomas, Juergen; Thompson, Emily; Thompson, Paul; Thompson, Peter; Thompson, Stan; Thomsen, Lotte Ansgaard; Thomson, Evelyn; Thomson, Mark; Thong, Wai Meng; Thun, Rudolf; Tian, Feng; Tibbetts, Mark James; Tic, Tomáš; Tikhomirov, Vladimir; Tikhonov, Yury; Timoshenko, Sergey; Tiouchichine, Elodie; Tipton, Paul; Tisserant, Sylvain; Todorov, Theodore; Todorova-Nova, Sharka; Toggerson, Brokk; Tojo, Junji; Tokár, Stanislav; Tokushuku, Katsuo; Tollefson, Kirsten; Tomoto, Makoto; Tompkins, Lauren; Toms, Konstantin; Tonoyan, Arshak; Topfel, Cyril; Topilin, Nikolai; Torrence, Eric; Torres, Heberth; Torró Pastor, Emma; Toth, Jozsef; Touchard, Francois; Tovey, Daniel; Trefzger, Thomas; Tremblet, Louis; Tricoli, Alesandro; Trigger, Isabel Marian; Trincaz-Duvoid, Sophie; Tripiana, Martin; Triplett, Nathan; Trischuk, William; Trocmé, Benjamin; Troncon, Clara; Trottier-McDonald, Michel; True, Patrick; Trzebinski, Maciej; Trzupek, Adam; Tsarouchas, Charilaos; Tseng, Jeffrey; Tsiakiris, Menelaos; Tsiareshka, Pavel; Tsionou, Dimitra; Tsipolitis, Georgios; Tsiskaridze, Shota; Tsiskaridze, Vakhtang; Tskhadadze, Edisher; Tsukerman, Ilya; Tsulaia, Vakhtang; Tsung, Jieh-Wen; Tsuno, Soshi; Tsybychev, Dmitri; Tua, Alan; Tudorache, Alexandra; Tudorache, Valentina; Tuggle, Joseph; Turala, Michal; Turecek, Daniel; Turk Cakir, Ilkay; Turlay, Emmanuel; Turra, Ruggero; Tuts, Michael; Tykhonov, Andrii; Tylmad, Maja; Tyndel, Mike; Tzanakos, George; Uchida, Kirika; Ueda, Ikuo; Ueno, Ryuichi; Ugland, Maren; Uhlenbrock, Mathias; Uhrmacher, Michael; Ukegawa, Fumihiko; Unal, Guillaume; Undrus, Alexander; Unel, Gokhan; Unno, Yoshinobu; Urbaniec, Dustin; Urquijo, Phillip; Usai, Giulio; Uslenghi, Massimiliano; Vacavant, Laurent; Vacek, Vaclav; Vachon, Brigitte; Vahsen, Sven; Valenta, Jan; Valentinetti, Sara; Valero, Alberto; Valkar, Stefan; Valladolid Gallego, Eva; Vallecorsa, Sofia; Valls Ferrer, Juan Antonio; Van Berg, Richard; Van Der Deijl, Pieter; van der Geer, Rogier; van der Graaf, Harry; Van Der Leeuw, Robin; van der Poel, Egge; van der Ster, Daniel; van Eldik, Niels; van Gemmeren, Peter; van Vulpen, Ivo; Vanadia, Marco; Vandelli, Wainer; Vaniachine, Alexandre; Vankov, Peter; Vannucci, Francois; Vari, Riccardo; Varnes, Erich; Varol, Tulin; Varouchas, Dimitris; Vartapetian, Armen; Varvell, Kevin; Vassilakopoulos, Vassilios; Vazeille, Francois; Vazquez Schroeder, Tamara; Vegni, Guido; Veillet, Jean-Jacques; Veloso, Filipe; Veness, Raymond; Veneziano, Stefano; Ventura, Andrea; Ventura, Daniel; Venturi, Manuela; Venturi, Nicola; Vercesi, Valerio; Verducci, Monica; Verkerke, Wouter; Vermeulen, Jos; Vest, Anja; Vetterli, Michel; Vichou, Irene; Vickey, Trevor; Vickey Boeriu, Oana Elena; Viehhauser, Georg; Viel, Simon; Villa, Mauro; Villaplana Perez, Miguel; Vilucchi, Elisabetta; Vincter, Manuella; Vinek, Elisabeth; Vinogradov, Vladimir; Virchaux, Marc; Virzi, Joseph; Vitells, Ofer; Viti, Michele; Vivarelli, Iacopo; Vives Vaque, Francesc; Vlachos, Sotirios; Vladoiu, Dan; Vlasak, Michal; Vogel, Adrian; Vokac, Petr; Volpi, Guido; Volpi, Matteo; Volpini, Giovanni; von der Schmitt, Hans; von Radziewski, Holger; von Toerne, Eckhard; Vorobel, Vit; Vorwerk, Volker; Vos, Marcel; Voss, Rudiger; Vossebeld, Joost; Vranjes, Nenad; Vranjes Milosavljevic, Marija; Vrba, Vaclav; Vreeswijk, Marcel; Vu Anh, Tuan; Vuillermet, Raphael; Vukotic, Ilija; Wagner, Wolfgang; Wagner, Peter; Wahlen, Helmut; Wahrmund, Sebastian; Wakabayashi, Jun; Walch, Shannon; Walder, James; Walker, Rodney; Walkowiak, Wolfgang; Wall, Richard; Waller, Peter; Walsh, Brian; Wang, Chiho; Wang, Haichen; Wang, Hulin; Wang, Jike; Wang, Jin; Wang, Rui; Wang, Song-Ming; Wang, Tan; Warburton, Andreas; Ward, Patricia; Wardrope, David Robert; Warsinsky, Markus; Washbrook, Andrew; Wasicki, Christoph; Watanabe, Ippei; Watkins, Peter; Watson, Alan; Watson, Ian; Watson, Miriam; Watts, Gordon; Watts, Stephen; Waugh, Anthony; Waugh, Ben; Weber, Michele; Weber, Pavel; Webster, Jordan S; Weidberg, Anthony; Weigell, Philipp; Weingarten, Jens; Weiser, Christian; Wells, Phillippa; Wenaus, Torre; Wendland, Dennis; Weng, Zhili; Wengler, Thorsten; Wenig, Siegfried; Wermes, Norbert; Werner, Matthias; Werner, Per; Werth, Michael; Wessels, Martin; Wetter, Jeffrey; Weydert, Carole; Whalen, Kathleen; White, Andrew; White, Martin; White, Sebastian; Whitehead, Samuel Robert; Whiteson, Daniel; Whittington, Denver; Wicek, Francois; Wicke, Daniel; Wickens, Fred; Wiedenmann, Werner; Wielers, Monika; Wienemann, Peter; Wiglesworth, Craig; Wiik-Fuchs, Liv Antje Mari; Wijeratne, Peter Alexander; Wildauer, Andreas; Wildt, Martin Andre; Wilhelm, Ivan; Wilkens, Henric George; Will, Jonas Zacharias; Williams, Eric; Williams, Hugh; Willis, William; Willocq, Stephane; Wilson, John; Wilson, Michael Galante; Wilson, Alan; Wingerter-Seez, Isabelle; Winkelmann, Stefan; Winklmeier, Frank; Wittgen, Matthias; Wollstadt, Simon Jakob; Wolter, Marcin Wladyslaw; Wolters, Helmut; Wong, Wei-Cheng; Wooden, Gemma; Wosiek, Barbara; Wotschack, Jorg; Woudstra, Martin; Wozniak, Krzysztof; Wraight, Kenneth; Wright, Michael; Wrona, Bozydar; Wu, Sau Lan; Wu, Xin; Wu, Yusheng; Wulf, Evan; Wynne, Benjamin; Xella, Stefania; Xiao, Meng; Xie, Song; Xu, Chao; Xu, Da; Xu, Lailin; Yabsley, Bruce; Yacoob, Sahal; Yamada, Miho; Yamaguchi, Hiroshi; Yamamoto, Akira; Yamamoto, Kyoko; Yamamoto, Shimpei; Yamamura, Taiki; Yamanaka, Takashi; Yamazaki, Takayuki; Yamazaki, Yuji; Yan, Zhen; Yang, Haijun; Yang, Un-Ki; Yang, Yi; Yang, Zhaoyu; Yanush, Serguei; Yao, Liwen; Yao, Yushu; Yasu, Yoshiji; Ybeles Smit, Gabriel Valentijn; Ye, Jingbo; Ye, Shuwei; Yilmaz, Metin; Yoosoofmiya, Reza; Yorita, Kohei; Yoshida, Rikutaro; Yoshihara, Keisuke; Young, Charles; Young, Christopher John; Youssef, Saul; Yu, Dantong; Yu, Jaehoon; Yu, Jie; Yuan, Li; Yurkewicz, Adam; Zabinski, Bartlomiej; Zaidan, Remi; Zaitsev, Alexander; Zajacova, Zuzana; Zanello, Lucia; Zanzi, Daniele; Zaytsev, Alexander; Zeitnitz, Christian; Zeman, Martin; Zemla, Andrzej; Zendler, Carolin; Zenin, Oleg; Ženiš, Tibor; Zinonos, Zinonas; Zenz, Seth; Zerwas, Dirk; Zevi della Porta, Giovanni; Zhang, Dongliang; Zhang, Huaqiao; Zhang, Jinlong; Zhang, Xueyao; Zhang, Zhiqing; Zhao, Long; Zhao, Zhengguo; Zhemchugov, Alexey; Zhong, Jiahang; Zhou, Bing; Zhou, Ning; Zhou, Yue; Zhu, Cheng Guang; Zhu, Hongbo; Zhu, Junjie; Zhu, Yingchun; Zhuang, Xuai; Zhuravlov, Vadym; Zibell, Andre; Zieminska, Daria; Zimin, Nikolai; Zimmermann, Robert; Zimmermann, Simone; Zimmermann, Stephanie; Ziolkowski, Michael; Zitoun, Robert; Živković, Lidija; Zmouchko, Viatcheslav; Zobernig, Georg; Zoccoli, Antonio; zur Nedden, Martin; Zutshi, Vishnu; Zwalinski, Lukasz

    2013-07-17

    This paper presents a summary of beam-induced backgrounds observed in the ATLAS detector and discusses methods to tag and remove background contaminated events in data. Trigger-rate based monitoring of beam-related backgrounds is presented. The correlations of backgrounds with machine conditions, such as residual pressure in the beam-pipe, are discussed. Results from dedicated beam-background simulations are shown, and their qualitative agreement with data is evaluated. Data taken during the passage of unpaired, i.e. non-colliding, proton bunches is used to obtain background-enriched data samples. These are used to identify characteristic features of beam-induced backgrounds, which then are exploited to develop dedicated background tagging tools. These tools, based on observables in the Pixel detector, the muon spectrometer and the calorimeters, are described in detail and their efficiencies are evaluated. Finally an example of an application of these techniques to a monojet analysis is given, which demonstra...

  12. SU-F-T-188: A Robust Treatment Planning Technique for Proton Pencil Beam Scanning Cranial Spinal Irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, M; Mehta, M; Badiyan, S; Young, K; Malyapa, R; Regine, W; Langen, K [University of Maryland School of Medicine, Baltimore, MD (United States); Yam, M [University of Florida Proton Therapy Institute, Jacksonville, FL (United States)

    2016-06-15

    Purpose: To propose a proton pencil beam scanning (PBS) cranial spinal irradiation (CSI) treatment planning technique robust against patient roll, isocenter offset and proton range uncertainty. Method: Proton PBS plans were created (Eclipse V11) for three previously treated CSI patients to 36 Gy (1.8 Gy/fractions). The target volume was separated into three regions: brain, upper spine and lower spine. One posterior-anterior (PA) beam was used for each spine region, and two posterior-oblique beams (15° apart from PA direction, denoted as 2PO-15) for the brain region. For comparison, another plan using one PA beam for the brain target (denoted as 1PA) was created. Using the same optimization objectives, 98% CTV was optimized to receive the prescription dose. To evaluate plan robustness against patient roll, the gantry angle was increased by 3° and dose was recalculated without changing the proton spot weights. On the re-calculated plan, doses were then calculated using 12 scenarios that are combinations of isocenter shift (±3mm in X, Y, and Z directions) and proton range variation (±3.5%). The worst-case-scenario (WCS) brain CTV dosimetric metrics were compared to the nominal plan. Results: For both beam arrangements, the brain field(s) and upper-spine field overlap in the T2–T5 region depending on patient anatomy. The maximum monitor unit per spot were 48.7%, 47.2%, and 40.0% higher for 1PA plans than 2PO-15 plans for the three patients. The 2PO-15 plans have better dose conformity. At the same level of CTV coverage, the 2PO-15 plans have lower maximum dose and higher minimum dose to the CTV. The 2PO-15 plans also showed lower WCS maximum dose to CTV, while the WCS minimum dose to CTV were comparable between the two techniques. Conclusion: Our method of using two posterior-oblique beams for brain target provides improved dose conformity and homogeneity, and plan robustness including patient roll.

  13. Proton Beam Therapy for Hepatocellular Carcinoma: A Comparison of Three Treatment Protocols

    Energy Technology Data Exchange (ETDEWEB)

    Mizumoto, Masashi; Okumura, Toshiyuki; Hashimoto, Takayuki [Proton Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki (Japan); Department of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki (Japan); Fukuda, Kuniaki [Department of Gastroenterology, University of Tsukuba, Tsukuba, Ibaraki (Japan); Oshiro, Yoshiko; Fukumitsu, Nobuyoshi [Proton Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki (Japan); Department of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki (Japan); Abei, Masato [Department of Gastroenterology, University of Tsukuba, Tsukuba, Ibaraki (Japan); Kawaguchi, Atsushi [Biostatistics Center, Kurume University, Fukuoka (Japan); Hayashi, Yasutaka; Ookawa, Ayako; Hashii, Haruko; Kanemoto, Ayae [Department of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki (Japan); Moritake, Takashi [Proton Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki (Japan); Department of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki (Japan); Tohno, Eriko [Department of Diagnostic Radiology, University of Tsukuba, Tsukuba, Ibaraki (Japan); Tsuboi, Koji [Proton Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki (Japan); Department of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki (Japan); Sakae, Takeji [Proton Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki (Japan); Sakurai, Hideyuki, E-mail: hsakurai@pmrc.tsukuba.ac.jp [Proton Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki (Japan); Department of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki (Japan)

    2011-11-15

    Background: Our previous results for treatment of hepatocellular carcinoma (HCC) with proton beam therapy revealed excellent local control with low toxicity. Three protocols were used to avoid late complications such as gastrointestinal ulceration and bile duct stenosis. In this study, we examined the efficacy of these protocols. Methods and Materials: The subjects were 266 patients (273 HCCs) treated by proton beam therapy at University of Tsukuba between January 2001 and December 2007. Three treatment protocols (A, 66 GyE in 10 fractions; B, 72.6 GyE in 22 fractions; and C, 77 GyE in 35 fractions) were used, depending on the tumor location. Results: Of the 266 patients, 104, 95, and 60 patients were treated with protocols A, B, and C, respectively. Seven patients with double lesions underwent two different protocols. The overall survival rates after 1, 3 and 5 years were 87%, 61%, and 48%, respectively (median survival, 4.2 years). Multivariate analysis showed that better liver function, small clinical target volume, and no prior treatment (outside the irradiated field) were associated with good survival. The local control rates after 1, 3, and 5 years were 98%, 87%, and 81%, respectively. Multivariate analysis did not identify any factors associated with good local control. Conclusions: This study showed that proton beam therapy achieved good local control for HCC using each of three treatment protocols. This suggests that selection of treatment schedules based on tumor location may be used to reduce the risk of late toxicity and maintain good treatment efficacy.

  14. Water calorimetry and ionization chamber dosimetry in an 85-MeV clinical proton beam.

    Science.gov (United States)

    Palmans, H; Seuntjens, J; Verhaegen, F; Denis, J M; Vynckier, S; Thierens, H

    1996-05-01

    In recent years, the increased use of proton beams for clinical purposes has enhanced the demand for accurate absolute dosimetry for protons. As calorimetry is the most direct way to establish the absorbed dose and because water has recently been accepted as standard material for this type of beam, the importance of water calorimetry is obvious. In this work we report water calorimeter operation in an 85-MeV proton beam and a comparison of the absorbed dose to water measured by ionometry with the dose resulting from water calorimetric measurements. To ensure a proper understanding of the heat defect for defined impurities in water for this type of radiation, a relative response study was first done in comparison with theoretical calculations of the heat defect. The results showed that pure hypoxic water and hydrogen-saturated water yielded the same response with practically zero heat defect, in agreement with the model calculations. The absorbed dose inferred from these measurements was then compared with the dose derived from ionometry by applying the European Charged Heavy Particle Dosimetry (ECHED) protocol. Restricting the comparison to chambers recommended in the protocol, the calorimeter dose was found to be 2.6% +/- 0.9% lower than the average ionometry dose. In order to estimate the significance of chamber-dependent effects in this deviation, measurements were performed using a set of ten ionization chambers of five different types. The maximum internal deviation in the ionometry results amounted to 1.1%. We detected no systematic chamber volume dependence, but observed a small but systematic effect of the chamber wall thickness. The observed deviation between calorimetry and ionometry can be attributed to a combination of the value of (Wair/e)p for protons, adopted in the ECHED protocol, the mass stopping power ratios of water to air for protons, and possibly small ionization chamber wall effects.

  15. A free-jet Hg target operating in a high magnetic field intersecting a high-power proton beam

    Science.gov (United States)

    Van Graves; Spampinato, Philip; Gabriel, Tony; Kirk, Harold; Simos, Nicholas; Tsang, Thomas; McDonald, Kirk; Peter Titus; Fabich, Adrian; Haseroth, Helmut; Lettry, Jacques

    2006-06-01

    A proof-of-principal experiment to investigate the interaction of a proton beam, high magnetic field, and high- Z target is planned to take place at CERN in early 2007. This experiment is part of the Muon Collider Collaboration, with participants from Brookhaven National Laboratory, Princeton University, Massachusetts Institute Of Technology, European Organization for Nuclear Research-CERN, Rutherford Appleton Laboratory, and Oak Ridge National Laboratory. An unconstrained mercury jet target system that interacts with a high power (1 MW) proton beam in a high magnetic field (15 T) is being designed. The Hg jet diameter is 1-cm with a velocity up to 20 m/s. A laser optical diagnostic system will be incorporated into the target design to permit observation of the dispersal of the jet resulting from interaction with a 24 GeV proton beam with up to 20×10 12 ppp. The target system includes instruments for sensing mercury vapor, temperature, flow rate, and sump tank level, and the means to position the jet relative to the magnetic axis of a solenoid and the proton beam. The design considerations for the system include all issues dealing with safely handling approximately 23 l of Hg, transporting the target system and the mercury to CERN, decommissioning the experiment, and returning the mildly activated equipment and Hg to the US.

  16. Radiative capture of cold neutrons by protons and deuteron photodisintegration with twisted beams

    Science.gov (United States)

    Afanasev, Andrei; Serbo, Valeriy G.; Solyanik, Maria

    2018-05-01

    We consider two basic nuclear reactions: capture of neutrons by protons, n + p → γ + d, and its time-reversed counterpart, photodisintegration of the deuteron, γ + d → n + p. In both of these cases we assume that the incoming beam of neutrons or photons is ‘twisted’ by having an azimuthal phase dependence, i.e., it carries an additional angular momentum along its direction of propagation. Taking a low-energy limit of these reactions, we derive relations between corresponding transition amplitudes and cross sections with plane-wave beams and twisted beams. Implications for experiments with twisted cold neutrons and twisted photon beams are discussed.

  17. The generation of absorbed dose profiles of proton beam in water using Geant4 code

    International Nuclear Information System (INIS)

    Christovao, Marilia T.; Campos, Tarcisio Passos R. de

    2007-01-01

    The present article approaches simulations on the proton beam radiation therapy, using an application based on the code GEANT4, with Open GL as a visualization drive and JAS3 (Java Analysis Studio) analysis data tools systems, implementing the AIDA interfaces. The proton radiotherapy is adapted to treat cancer or other benign tumors that are close to sensitive structures, since it allows precise irradiation of the target with high doses, while the health tissues adjacent to vital organs and tissues are preserved, due to physical property of dose profile. GEANT4 is a toolkit for simulating the transport of particles through matter, in complex geometries. Taking advantage of the object-oriented project features, the user can adapt or extend the tool in all domain, due to the flexibility of the code, providing a subroutine's group for materials definition, geometries and particles properties in agreement with the user's needs to generate the Monte Carlo simulation. In this paper, the parameters of beam line used in the simulation possess adjustment elements, such as: the range shifter, composition and dimension; the beam line, energy, intensity, length, according with physic processes applied. The simulation result is the depth dose profiles on water, dependent on the various incident beam energy. Starting from those profiles, one can define appropriate conditions for proton radiotherapy in ocular region. (author)

  18. TU-H-CAMPUS-TeP3-03: Dose Enhancement by Gold Nanoparticles Around the Bragg Peak of Proton Beams

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, J; Sutherland, K [Department of Medical Physics, Hokkaido University Graduate School of Medicine (Japan); Hashimoto, T [Department of Radiation Medicine, Hokkaido University Graduate School of Medicine (Japan); Peng, H; Xing, L [Department of Radiation Oncology, Stanford University and Global Station for Quantum Medical Science and Engineering, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University (Japan); Shirato, H [Department of Radiation Medicine, Hokkaido University Graduate School of Medicine and Global Station for Quantum Medical Science and Engineering, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University (Japan); Date, H [Faculty of Health Sciences, Hokkaido University (Japan)

    2016-06-15

    Purpose: To make clear the spatial distribution of dose enhancement around gold nanoparticles (GNPs) located near the proton Bragg peak, and to evaluate the potential of GNPs as a radio sensitizer. Methods: The dose enhancement by electrons emitted from GNPs under proton irradiation was estimated by Geant4 Monte Carlo simulation toolkit in two steps. In an initial macroscopic step, 100 and 195 MeV proton beams were incident on a water cube, 30 cm on a side. Energy distributions of protons were calculated at four depths, 50% and 75% proximal to the Bragg peak, 100% peak, and 75% distal to the peak (P50, P75, Peak, and D75, respectively). In a subsequent microscopic step, protons with the energy distribution calculated above were incident on a 20 nm diameter GNP in a nanometer-size water box and the spatial distribution of dose around the GNP was determined for each energy distribution. The dose enhancement factor (DEF) was also deduced. Results: The dose enhancement effect was spread to several tens of nanometers in the both depth and radial directions. The enhancement area increased in the order of P50, P75, Peak, and D75 for both cases with 100 and 195 MeV protons. In every position around the Bragg peak, the 100 MeV beam resulted in a higher dose enhancement than the 195 MeV beam. At P75, the average and maximum DEF were 3.9 and 17.0 for 100 MeV, and 3.5 and 16.2 for 195 MeV, respectively. These results indicate that lower energy protons caused higher dose enhancement in this incident proton energy range. Conclusion: The dose enhancement around GNPs spread as the position in the Bragg peak region becomes deeper and depends on proton energy. It is expected that GNPs can be used as a radio sensitizer with consideration of the location and proton beam energy.

  19. Polarizing a stored proton beam by spin flip? - A high statistic reanalysis

    International Nuclear Information System (INIS)

    Oellers, Dieter

    2011-01-01

    Prompted by recent, conflicting calculations, we have carried out a measurement of the spin flip cross section in low-energy electron-proton scattering. The experiment uses the cooling electron beam at COSY as an electron target. A reanalysis of the data leeds to a reduced statistical errors resulting in a factor of 4 reduced upper limit for the spin flip cross section. The measured cross sections are too small for making spin flip a viable tool in polarizing a stored beam.

  20. Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions

    Directory of Open Access Journals (Sweden)

    Abigail T. Berman

    2015-07-01

    Full Text Available Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT, through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung cancer, present the existing data in early-stage and locally-advanced non-small cell lung cancer (NSCLC, as well as in special situations such as re-irradiation and post-operative radiation therapy. We then present the technical challenges, such as anatomic changes and motion management, and future directions for PBT in lung cancer, including pencil beam scanning.