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Sample records for proton beam transport

  1. Intense-proton-beam transport through an insulator beam guide

    International Nuclear Information System (INIS)

    Hanamori, Susumu; Kawata, Shigeo; Kikuchi, Takashi; Fujita, Akira; Chiba, Yasunobu; Hikita, Taisuke; Kato, Shigeru

    1998-01-01

    In this paper we study intense-proton-beam transport through an insulator guide. In our previous papers (Jpn. J. Appl. Phys. 34 (1995) L520, Jpn. J. Appl. Phys. 35 (1996) L1127) we proposed a new system for intense-electron-beam transport using an insulator guide. In contrast to the electron beam, an intense-proton beam tends to generate a virtual anode, because of the large proton mass. The virtual anode formation at the initial stage is prevented by prefilled plasma in this system. During and after this, electrons are extracted from the plasma generated at the insulator surface by the proton beam space charge and expand over the transport area. The proton beam charge is effectively neutralized by the electrons. Consequently, the proton beam propagates efficiently through the insulator beam guide. The electron extraction is self-regulated by the net space charge of the proton beam. (author)

  2. Beam collimation and transport of laser-accelerated protons by a solenoid field

    Energy Technology Data Exchange (ETDEWEB)

    Harres, K; Alber, I; Guenther, M; Nuernberg, F; Otten, A; Schuetrumpf, J; Roth, M [Technische Universitaet Darmstadt, Institut fuer Kernphysik, Schlossgartenstrasse 9, 64289 Darmstadt (Germany); Tauschwitz, A; Bagnoud, V [GSI - Hemholtzzentrum fur Schwerionenforschung GmbH, Plasmaphysik and PHELIX, Planckstrasse 1, 64291 Darmstadt (Germany); Daido, H; Tampo, M [Photo Medical Research Center, JAEA, 8-1 Umemidai, Kizugawa-city, Kyoto, 619-0215 (Japan); Schollmeier, M, E-mail: k.harres@gsi.d [Sandia National Laboratories, Albuquerque NM 87185 (United States)

    2010-08-01

    A pulsed high field solenoid was used in a laser-proton acceleration experiment to collimate and transport the proton beam that was generated at the irradiation of a flat foil by a high intensity laser pulse. 10{sup 12} particles at an energy of 2.3 MeV could be caught and transported over a distance of more than 240 mm. Strong space charge effects occur, induced by the high field of the solenoid that forces all co-moving electrons down the the solenoid's axis, building up a strong negative space charge that interacts with the proton beam. This leads to an aggregation of the proton beam around the solenoid's axis and therefore to a stronger focusing effect. The collimation and transport of laser-accelerated protons is the first step to provide these unique beams for further applications like post-acceleration by conventional accelerator structures.

  3. Beam collimation and transport of laser-accelerated protons by a solenoid field

    International Nuclear Information System (INIS)

    Harres, K; Alber, I; Guenther, M; Nuernberg, F; Otten, A; Schuetrumpf, J; Roth, M; Tauschwitz, A; Bagnoud, V; Daido, H; Tampo, M; Schollmeier, M

    2010-01-01

    A pulsed high field solenoid was used in a laser-proton acceleration experiment to collimate and transport the proton beam that was generated at the irradiation of a flat foil by a high intensity laser pulse. 10 12 particles at an energy of 2.3 MeV could be caught and transported over a distance of more than 240 mm. Strong space charge effects occur, induced by the high field of the solenoid that forces all co-moving electrons down the the solenoid's axis, building up a strong negative space charge that interacts with the proton beam. This leads to an aggregation of the proton beam around the solenoid's axis and therefore to a stronger focusing effect. The collimation and transport of laser-accelerated protons is the first step to provide these unique beams for further applications like post-acceleration by conventional accelerator structures.

  4. Injector and beam transport simulation study of proton dielectric wall accelerator

    International Nuclear Information System (INIS)

    Zhao, Quantang; Yuan, P.; Zhang, Z.M.; Cao, S.C; Shen, X.K.; Jing, Y.; Ma, Y.Y.; Yu, C.S.; Li, Z.P.; Liu, M.; Xiao, R.Q.; Zhao, H.W.

    2012-01-01

    A simulation study of a short-pulsed proton injector for, and beam transport in, a dielectric wall accelerator (DWA) has been carried out using the particle-in-cell (PIC) code Warp. It was shown that applying “tilt pulse” voltage waveforms on three electrodes enables the production of a shorter bunch by the injector. The fields in the DWA beam tube were simulated using Computer Simulation Technology’s Microwave Studio (CST MWS) package, with various choices for the boundary conditions. For acceleration in the DWA, the beam transport was simulated with Warp, using applied fields obtained by running CST MWS. Our simulations showed that the electric field at the entrance to the DWA represents a challenging issue for the beam transport. We thus simulated a configuration with a mesh at the entrance of the DWA, intended to improve the entrance field. In these latter simulations, a proton bunch was successfully accelerated from 130 keV to about 36 MeV in a DWA with a length of 36.75 cm. As the beam bunch progresses, its transverse dimensions diminish from (roughly) 0.5×0.5 cm to 0.2×0.4 cm. The beam pulse lengthens from 1 cm to 2 cm due to lack of longitudinal compression fields. -- Highlights: ► A pulse proton injector with tilt voltages on the three electrodes was simulated. ► The fields in different part of the DWA were simulated with CST and analyzed. ► The proton beam transport in DWA was simulated with Warp successfully. ► The simulation can help for designing a real DWA.

  5. Beam collimation and transport of quasineutral laser-accelerated protons by a solenoid field

    International Nuclear Information System (INIS)

    Harres, K.; Alber, I.; Guenther, M.; Nuernberg, F.; Otten, A.; Schuetrumpf, J.; Roth, M.; Tauschwitz, A.; Bagnoud, V.; Daido, H.; Tampo, M.; Schollmeier, M.

    2010-01-01

    This article reports about controlling laser-accelerated proton beams with respect to beam divergence and energy. The particles are captured by a pulsed high field solenoid with a magnetic field strength of 8.6 T directly behind a flat target foil that is irradiated by a high intensity laser pulse. Proton beams with energies around 2.3 MeV and particle numbers of 10 12 could be collimated and transported over a distance of more than 300 mm. In contrast to the protons the comoving electrons are strongly deflected by the solenoid field. They propagate at a submillimeter gyroradius around the solenoid's axis which could be experimentally verified. The originated high flux electron beam produces a high space charge resulting in a stronger focusing of the proton beam than expected by tracking results. Leadoff particle-in-cell simulations show qualitatively that this effect is caused by space charge attraction due to the comoving electrons. The collimation and transport of laser-accelerated protons is the first step to provide these unique beams for further applications such as postacceleration by conventional accelerator structures.

  6. Non-Linear Beam Transport System for the LENS 7 MeV Proton Beam

    CERN Document Server

    Jones, William P; Derenchuk, Vladimir Peter; Rinckel, Thomas; Solberg, Keith

    2005-01-01

    A beam transport system has been designed to carry a high-intensity low-emittance proton beam from the exit of the RFQ-DTL acceleration system of the Indiana University Low Energy Neutron System (LENS)* to the neutron production target. The goal of the design was to provide a beam of uniform density over a 3cm by 3cm area at the target. Two octupole magnets** are employed in the beam line to provide the necessary beam phase space manipulations to achieve this goal. First order calculations were done using TRANSPORT and second order calculations have been performed using TURTLE. Second order simulations have been done using both a Gaussian beam distribution and a particle set generated by calculations of beam transport through the RFQ-DTL using PARMILA. Comparison of the design characteristics with initial measurements from the LENS commissioning process will be made.

  7. Transport of laser accelerated proton beams and isochoric heating of matter

    International Nuclear Information System (INIS)

    Roth, M; Alber, I; Guenther, M; Harres, K; Bagnoud, V; Brown, C; Gregori, G; Clarke, R; Heathcote, R; Li, B; Daido, H; Fernandez, J; Flippo, K; Gaillard, S; Gauthier, C; Glenzer, S; Kritcher, A; Kugland, N; LePape, S; Makita, M

    2010-01-01

    The acceleration of intense proton and ion beams by ultra-intense lasers has matured to a point where applications in basic research and technology are being developed. Crucial for harvesting the unmatched beam parameters driven by the relativistic electron sheath is the precise control of the beam. We report on recent experiments using the PHELIX laser at GSI, the VULCAN laser at RAL and the TRIDENT laser at LANL to control and use laser accelerated proton beams for applications in high energy density research. We demonstrate efficient collimation of the proton beam using high field pulsed solenoid magnets, a prerequisite to capture and transport the beam for applications. Furthermore we report on two campaigns to use intense, short proton bunches to isochorically heat solid targets up to the warm dense matter state. The temporal profile of the proton beam allows for rapid heating of the target, much faster than the hydrodynamic response time thereby creating a strongly coupled plasma at solid density. The target parameters are then probed by X-ray Thomson scattering (XRTS) to reveal the density and temperature of the heated volume. This combination of two powerful techniques developed during the past few years allows for the generation and investigation of macroscopic samples of matter in states present in giant planets or the interior of the earth.

  8. Transport of laser accelerated proton beams and isochoric heating of matter

    Energy Technology Data Exchange (ETDEWEB)

    Roth, M; Alber, I; Guenther, M; Harres, K [Inst. fuer Kernphysik, Technische Universitaet Darmstadt, 64289 Darmstadt (Germany); Bagnoud, V [GSI Helmholtzzentrum f. Schwerionenforschung GmbH, 64291 Darmstadt (Germany); Brown, C; Gregori, G [Clarendon Laboratory, University of Oxford, Parks Road, Oxford OX1 3PU (United Kingdom); Clarke, R; Heathcote, R; Li, B [STFC, Rutherford Appleton Laboratory, Chilton, Didcot, OX14 OQX (United Kingdom); Daido, H [Photo Medical Research Center, JAEA, Kizugawa-City, Kyoto 619-0215 (Japan); Fernandez, J; Flippo, K; Gaillard, S; Gauthier, C [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Glenzer, S; Kritcher, A; Kugland, N; LePape, S [Lawrence Livermore National Laboratory, Livermore, California 94551 (United States); Makita, M, E-mail: markus.roth@physik.tu-darmstadt.d [School of Mathematics and Physics, Queen' s University of Belfast, Belfast BT7 1NN (United Kingdom)

    2010-08-01

    The acceleration of intense proton and ion beams by ultra-intense lasers has matured to a point where applications in basic research and technology are being developed. Crucial for harvesting the unmatched beam parameters driven by the relativistic electron sheath is the precise control of the beam. We report on recent experiments using the PHELIX laser at GSI, the VULCAN laser at RAL and the TRIDENT laser at LANL to control and use laser accelerated proton beams for applications in high energy density research. We demonstrate efficient collimation of the proton beam using high field pulsed solenoid magnets, a prerequisite to capture and transport the beam for applications. Furthermore we report on two campaigns to use intense, short proton bunches to isochorically heat solid targets up to the warm dense matter state. The temporal profile of the proton beam allows for rapid heating of the target, much faster than the hydrodynamic response time thereby creating a strongly coupled plasma at solid density. The target parameters are then probed by X-ray Thomson scattering (XRTS) to reveal the density and temperature of the heated volume. This combination of two powerful techniques developed during the past few years allows for the generation and investigation of macroscopic samples of matter in states present in giant planets or the interior of the earth.

  9. Dynamics of laser-driven proton beam focusing and transport into solid density matter

    Science.gov (United States)

    Kim, J.; McGuffey, C.; Beg, F.; Wei, M.; Mariscal, D.; Chen, S.; Fuchs, J.

    2016-10-01

    Isochoric heating and local energy deposition capabilities make intense proton beams appealing for studying high energy density physics and the Fast Ignition of inertial confinement fusion. To study proton beam focusing that results in high beam density, experiments have been conducted using different target geometries irradiated by a kilojoule, 10 ps pulse of the OMEGA EP laser. The beam focus was measured by imaging beam-induced Cu K-alpha emission on a Cu foil that was positioned at a fixed distance. Compared to a free target, structured targets having shapes of wedge and cone show a brighter and narrower K-alpha radiation emission spot on a Cu foil indicating higher beam focusability. Experimentally observed images with proton radiography demonstrate the existence of transverse fields on the structures. Full-scale simulations including the contribution of a long pulse duration of the laser confirm that such fields can be caused by hot electrons moving through the structures. The simulated fields are strong enough to reflect the diverging main proton beam and pinch a transverse probe beam. Detailed simulation results including the beam focusing and transport of the focused intense proton beam in Cu foil will be presented. This work was supported by the National Laser User Facility Program through Award DE-NA0002034.

  10. Conceptual design of proton beam window

    International Nuclear Information System (INIS)

    Teraoku, Takuji; Kaminaga, Masanori; Terada, Atsuhiko; Ishikura, Syuichi; Kinoshita, Hidetaka; Hino, Ryutaro

    2001-01-01

    In a MW-scale neutron scattering facility coupled with a high-intensity proton accelerator, a proton beam window is installed as the boundary between a high vacuum region of the proton beam transport line and a helium environment around the target assembly working as a neutron source. The window is cooled by water so as to remove high volumetric heat generated by the proton beam. A concept of the flat-type proton beam window consisting of two plates of 3 mm thick was proposed, which was found to be feasible under the proton beam power of 5 MW through thermal-hydraulic and structural strength analyses. (authors)

  11. High intensity proton beam transportation through fringe field of 70 MeV compact cyclotron to beam line targets

    Science.gov (United States)

    Zhang, Xu; Li, Ming; Wei, Sumin; Xing, Jiansheng; Hu, Yueming; Johnson, Richard R.; Piazza, Leandro; Ryjkov, Vladimir

    2016-06-01

    From the stripping points, the high intensity proton beam of a compact cyclotron travels through the fringe field area of the machine to the combination magnet. Starting from there the beams with various energy is transferred to the switching magnet for distribution to the beam line targets. In the design of the extraction and transport system for the compact proton cyclotron facilities, such as the 70 MeV in France and the 100 MeV in China, the space charge effect as the beam crosses the fringe field has not been previously considered; neither has the impact on transverse beam envelope coupled from the longitudinal direction. Those have been concerned much more with the higher beam-power because of the beam loss problem. In this paper, based on the mapping data of 70 MeV cyclotron including the fringe field by BEST Cyclotron Inc (BEST) and combination magnet field by China Institute of Atomic Energy (CIAE), the beam extraction and transport are investigated for the 70 MeV cyclotron used on the SPES project at Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro (INFN-LNL). The study includes the space charge effect and longitudinal and transverse coupling mentioned above, as well as the matching of beam optics using the beam line for medical isotope production as an example. In addition, the designs of the ±45° switching magnets and the 60° bending magnet for the extracted beam with the energy from 35 MeV to 70 MeV have been made. Parts of the construction and field measurements of those magnets have been done as well. The current result shows that, the design considers the complexity of the compact cyclotron extraction area and fits the requirements of the extraction and transport for high intensity proton beam, especially at mA intensity levels.

  12. High intensity proton beam transportation through fringe field of 70 MeV compact cyclotron to beam line targets

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xu, E-mail: emmazhang103@gmail.com [China Institute of Atomic Energy (China); Li, Ming; Wei, Sumin; Xing, Jiansheng; Hu, Yueming [China Institute of Atomic Energy (China); Johnson, Richard R.; Piazza, Leandro; Ryjkov, Vladimir [BEST Cyclotron Inc (Canada)

    2016-06-01

    From the stripping points, the high intensity proton beam of a compact cyclotron travels through the fringe field area of the machine to the combination magnet. Starting from there the beams with various energy is transferred to the switching magnet for distribution to the beam line targets. In the design of the extraction and transport system for the compact proton cyclotron facilities, such as the 70 MeV in France and the 100 MeV in China, the space charge effect as the beam crosses the fringe field has not been previously considered; neither has the impact on transverse beam envelope coupled from the longitudinal direction. Those have been concerned much more with the higher beam-power because of the beam loss problem. In this paper, based on the mapping data of 70 MeV cyclotron including the fringe field by BEST Cyclotron Inc (BEST) and combination magnet field by China Institute of Atomic Energy (CIAE), the beam extraction and transport are investigated for the 70 MeV cyclotron used on the SPES project at Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro (INFN–LNL). The study includes the space charge effect and longitudinal and transverse coupling mentioned above, as well as the matching of beam optics using the beam line for medical isotope production as an example. In addition, the designs of the ±45° switching magnets and the 60° bending magnet for the extracted beam with the energy from 35 MeV to 70 MeV have been made. Parts of the construction and field measurements of those magnets have been done as well. The current result shows that, the design considers the complexity of the compact cyclotron extraction area and fits the requirements of the extraction and transport for high intensity proton beam, especially at mA intensity levels.

  13. Fan-beam intensity modulated proton therapy.

    Science.gov (United States)

    Hill, Patrick; Westerly, David; Mackie, Thomas

    2013-11-01

    This paper presents a concept for a proton therapy system capable of delivering intensity modulated proton therapy using a fan beam of protons. This system would allow present and future gantry-based facilities to deliver state-of-the-art proton therapy with the greater normal tissue sparing made possible by intensity modulation techniques. A method for producing a divergent fan beam of protons using a pair of electromagnetic quadrupoles is described and particle transport through the quadrupole doublet is simulated using a commercially available software package. To manipulate the fan beam of protons, a modulation device is developed. This modulator inserts or retracts acrylic leaves of varying thickness from subsections of the fan beam. Each subsection, or beam channel, creates what effectively becomes a beam spot within the fan area. Each channel is able to provide 0-255 mm of range shift for its associated beam spot, or stop the beam and act as an intensity modulator. Results of particle transport simulations through the quadrupole system are incorporated into the MCNPX Monte Carlo transport code along with a model of the range and intensity modulation device. Several design parameters were investigated and optimized, culminating in the ability to create topotherapy treatment plans using distal-edge tracking on both phantom and patient datasets. Beam transport calculations show that a pair of electromagnetic quadrupoles can be used to create a divergent fan beam of 200 MeV protons over a distance of 2.1 m. The quadrupole lengths were 30 and 48 cm, respectively, with transverse field gradients less than 20 T/m, which is within the range of water-cooled magnets for the quadrupole radii used. MCNPX simulations of topotherapy treatment plans suggest that, when using the distal edge tracking delivery method, many delivery angles are more important than insisting on narrow beam channel widths in order to obtain conformal target coverage. Overall, the sharp distal

  14. Formation of an intense proton beam of microsecond duration

    Energy Technology Data Exchange (ETDEWEB)

    Engelko, V [Efremov Inst. of Electrophysical Apparatus, St. Petersburg (Russian Federation); Giese, H; Schalk, S [Forschungszentrum Karlsruhe (Germany)

    1997-12-31

    The proton beam facility PROFA serves as a test installation for ion source development and beam transport optimization for an intense pulsed proton beam of low kinetic energy, envisaged for ITER divertor load simulation. The present state of the investigations is discussed with emphasis on the diode operation parameters, beam divergence and beam transport efficiency. (author). 7 figs., 5 refs.

  15. Calculation of channels for forming and transport of medical proton beams at the JINR phasotron

    International Nuclear Information System (INIS)

    Kuz'min, E.S.; Mirokhin, I.V.; Molokanov, A.G.; Obukhov, Yu.L.; Savchenko, O.V.

    1984-01-01

    Results of numerical simulation of shaping and transporting processes of therapeutic proton beams with a modified Bragg curve at the JINR phasotron are presented. The mean energy of proton beams are about 100, 130 and 200 MeV. To provide the flat-topped depth-dose distributions with a steep back slope, the method of shaping with a necessary energy spectrum from a nonmonoenergetic beam is used. It is shown by the calculations that it is possible to choose such modes of the channel operation at which clinical-physical requirements to the parameters of medical proton beams are satisfied. Extensions of flat-tops of dose peaks are 1.3 g/cm 2 , 1.7 g/cm 2 and 3.5 g/cm 2 for the 100 MeV, 130 MeV and 200 MeV beam energies, respectively. Dose rate in the peaks of modified distributions are not less than 100 rad per minute

  16. Improved design of proton source and low energy beam transport line for European Spallation Source

    Energy Technology Data Exchange (ETDEWEB)

    Neri, L., E-mail: neri@lns.infn.it; Celona, L.; Gammino, S.; Mascali, D.; Castro, G.; Ciavola, G. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, 95123 Catania (Italy); Torrisi, G. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, 95123 Catania (Italy); Dipartimento di Ingegneria dell’Informazione, delle Infrastrutture e dell’Energia Sostenibile, Università Mediterranea di Reggio Calabria, Via Graziella, 89122 Reggio Calabria (Italy); Cheymol, B.; Ponton, A. [European Spallation Source ESS AB, Lund (Sweden); Galatà, A. [Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, Viale dell' università 2, 35020 Legnaro (Italy); Patti, G. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, 95123 Catania (Italy); Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, Viale dell' università 2, 35020 Legnaro (Italy); Gozzo, A.; Lega, L. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, 95123 Catania (Italy); Dipartimento di Ingegneria Informatica e delle Telecomunicazioni, Università degli Studi di Catania, Viale Andrea Doria 6, 95123 Catania (Italy)

    2014-02-15

    The design update of the European Spallation Source (ESS) accelerator is almost complete and the construction of the prototype of the microwave discharge ion source able to provide a proton beam current larger than 70 mA to the 3.6 MeV Radio Frequency Quadrupole (RFQ) started. The source named PS-ESS (Proton Source for ESS) was designed with a flexible magnetic system and an extraction system able to merge conservative solutions with significant advances. The ESS injector has taken advantage of recent theoretical updates and new plasma diagnostics tools developed at INFN-LNS (Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare). The design strategy considers the PS-ESS and the low energy beam transport line as a whole, where the proton beam behaves like an almost neutralized non-thermalized plasma. Innovative solutions have been used as hereinafter described. Thermo-mechanical optimization has been performed to withstand the chopped beam and the misaligned focused beam over the RFQ input collimator; the results are reported here.

  17. High field superconducting beam transport in a BNL primary proton beam

    International Nuclear Information System (INIS)

    Allinger, J.; Brown, H.N.; Carroll, A.S.; Danby, G.; DeVito, B.; Glenn, J.W.; Jackson, J.; Keith, W.; Lowenstein, D.; Prodell, A.G.

    1979-01-01

    Construction of a slow external beam switchyard at the BNL AGS requires a rapid 20.4 0 bend in the upstream end of the beam line. Two curved superconducting window dipole magnets, operating at 6.0 T and about 80% of short sample magnetic field, will be utilized with two small superconducting sextupoles to provide the necessary deflection for a 28.5 GeV/c primary proton beam. Because the magnets will operate in a primary proton beam environment, they are designed to absorb large amounts of radiation heating from the beam without quenching. The field quality of the superconducting magnets is extremely good. Computer field calculations indicate a field error, ΔB/B 0 , equivalent to approx. = 1 x 10 -4 up to 75% of the 8.26 cm full aperture diameter in the magnet

  18. Method and apparatus for laser-controlled proton beam radiology

    Science.gov (United States)

    Johnstone, Carol J.

    1998-01-01

    A proton beam radiology system provides cancer treatment and proton radiography. The system includes an accelerator for producing an H.sup.- beam and a laser source for generating a laser beam. A photodetachment module is located proximate the periphery of the accelerator. The photodetachment module combines the H.sup.- beam and laser beam to produce a neutral beam therefrom within a subsection of the H.sup.- beam. The photodetachment module emits the neutral beam along a trajectory defined by the laser beam. The photodetachment module includes a stripping foil which forms a proton beam from the neutral beam. The proton beam is delivered to a conveyance segment which transports the proton beam to a patient treatment station. The photodetachment module further includes a laser scanner which moves the laser beam along a path transverse to the cross-section of the H.sup.- beam in order to form the neutral beam in subsections of the H.sup.- beam. As the scanning laser moves across the H.sup.- beam, it similarly varies the trajectory of the proton beam emitted from the photodetachment module and in turn varies the target location of the proton beam upon the patient. Intensity modulation of the proton beam can also be achieved by controlling the output of the laser.

  19. Optimization of laser accelerated proton beams for possible applications

    Energy Technology Data Exchange (ETDEWEB)

    Al-Omari, Husam [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Planckstrasse 1, 64291 Darmstadt (Germany); Collaboration: LIGHT-Collaboration

    2013-07-01

    Optimization of transported proton beams through a pulsed solenoid in the laser proton experiment LIGHT at GSI has been studied numerically. TraceWin, SRIM and ATIMA codes were employed for this study with an initial distribution generated by MATLAB program fitted to Phelix measured data. Two individual tools have been used to produce protons beam as a later beam source: an aperture located at the solenoid focal spot as energy selection tool; and a scattering foil at a suitable position in the beam path that smoothens the simulated radial energy imprint on the beam profile. The simulation results show that the proton energy spectrum is filtered by the aperture and the radial energy correlation is smoothened.

  20. Linac4 45 keV Proton Beam Measurements

    CERN Document Server

    Bellodi, G; Hein, L M; Lallement, J-B; Lombardi, A M; Midttun, O; Scrivens, R; Posocco, P A

    2013-01-01

    Linac4 is a 160 MeV normal-conducting H- linear accelerator, which will replace the 50 MeV proton Linac2 as injector for the CERN proton complex. Commissioning of the low energy part - comprising the H - source, a 45 keV Low Energy Beam Transport line (LEBT), a 3 MeV Radiofrequency Quadrupole (RFQ) and a Medium Energy Beam Transport (MEBT) - will start in fall 2012 on a dedicated test stand installation. In preparation to this, preliminary measurements were taken using a 45 keV proton source and a temporary LEBT setup, with the aim of characterising the output beam by comparison with the predictions of simulations. At the same time this allowed a first verification of the functionalities of diagnostics instrumentation and acquisition software tools. Measurements of beam profile, emittance and intensity were taken in three different setups: right after the source, after the first and after the second LEBT solenoids respectively. Particle distributions were reconstructed from emittance scan...

  1. Beam collimation and energy spectrum compression of laser-accelerated proton beams using solenoid field and RF cavity

    Energy Technology Data Exchange (ETDEWEB)

    Teng, J.; Gu, Y.Q., E-mail: tengjian@mail.ustc.edu.cn; Zhu, B.; Hong, W.; Zhao, Z.Q.; Zhou, W.M.; Cao, L.F.

    2013-11-21

    This paper presents a new method of laser produced proton beam collimation and spectrum compression using a combination of a solenoid field and a RF cavity. The solenoid collects laser-driven protons efficiently within an angle that is smaller than 12 degrees because it is mounted few millimeters from the target, and collimates protons with energies around 2.3 MeV. The collimated proton beam then passes through a RF cavity to allow compression of the spectrum. Particle-in-cell (PIC) simulations demonstrate the proton beam transport in the solenoid and RF electric fields. Excellent energy compression and collection efficiency of protons are presented. This method for proton beam optimization is suitable for high repetition-rate laser acceleration proton beams, which could be used as an injector for a conventional proton accelerator.

  2. Beam collimation and energy spectrum compression of laser-accelerated proton beams using solenoid field and RF cavity

    Science.gov (United States)

    Teng, J.; Gu, Y. Q.; Zhu, B.; Hong, W.; Zhao, Z. Q.; Zhou, W. M.; Cao, L. F.

    2013-11-01

    This paper presents a new method of laser produced proton beam collimation and spectrum compression using a combination of a solenoid field and a RF cavity. The solenoid collects laser-driven protons efficiently within an angle that is smaller than 12 degrees because it is mounted few millimeters from the target, and collimates protons with energies around 2.3 MeV. The collimated proton beam then passes through a RF cavity to allow compression of the spectrum. Particle-in-cell (PIC) simulations demonstrate the proton beam transport in the solenoid and RF electric fields. Excellent energy compression and collection efficiency of protons are presented. This method for proton beam optimization is suitable for high repetition-rate laser acceleration proton beams, which could be used as an injector for a conventional proton accelerator.

  3. Beam collimation and energy spectrum compression of laser-accelerated proton beams using solenoid field and RF cavity

    International Nuclear Information System (INIS)

    Teng, J.; Gu, Y.Q.; Zhu, B.; Hong, W.; Zhao, Z.Q.; Zhou, W.M.; Cao, L.F.

    2013-01-01

    This paper presents a new method of laser produced proton beam collimation and spectrum compression using a combination of a solenoid field and a RF cavity. The solenoid collects laser-driven protons efficiently within an angle that is smaller than 12 degrees because it is mounted few millimeters from the target, and collimates protons with energies around 2.3 MeV. The collimated proton beam then passes through a RF cavity to allow compression of the spectrum. Particle-in-cell (PIC) simulations demonstrate the proton beam transport in the solenoid and RF electric fields. Excellent energy compression and collection efficiency of protons are presented. This method for proton beam optimization is suitable for high repetition-rate laser acceleration proton beams, which could be used as an injector for a conventional proton accelerator

  4. Laser-accelerated proton beams as a new particle source

    Energy Technology Data Exchange (ETDEWEB)

    Nuernberg, Frank

    2010-11-15

    The framework of this thesis is the investigation of the generation of proton beams using high-intensity laser pulses. In this work, an experimental method to fully reconstruct laser-accelerated proton beam parameters, called radiochromic film imaging spectroscopy (RIS), was developed. Since the proton beam expansion is a plasma expansion with accompanying electrons, a low-energy electron spectrometer was developed, built and tested to study the electron distribution matching to the proton beam energy distribution. Two experiments were carried out at the VULCAN Petawatt laser with the aim of showing dynamic control and enhancement of proton acceleration using multiple or defocused laser pulses. Irradiating the target with a long pulse, low-intensity laser (10{sup 12} W/cm{sup 2}) prior to the main pulse ({proportional_to}ns), an optimum pre-plasma density scale length of 60 {mu}m is generated leading to an enhancement of the maximum proton energy ({proportional_to}25%), the proton flux (factor of 3) and the beam uniformity. Proton beams were generated more efficiently than previously by driving thinner target foils at a lower intensity over a large area. The optimum condition was a 2 {mu}m foil irradiated with an intensity of 10{sup 19} W/cm{sup 2} onto a 60 {mu}m spot. Laser to proton beam efficiencies of 7.8% have been achieved (2.2% before) - one of the highest conversion efficiencies ever achieved. In the frame of this work, two separate experiments at the TRIDENT laser system have shown that these laser-accelerated proton beams, with their high number of particles in a short pulse duration, are well-suited for creating isochorically heated matter in extreme conditions. Besides the manipulation of the proton beam parameters directly during the generation, the primary aim of this thesis was the capture, control and transport of laser-accelerated proton beams by a solenoidal magnetic field lense for further purpose. In a joint project proposal, the laser and

  5. Laser-accelerated proton beams as a new particle source

    International Nuclear Information System (INIS)

    Nuernberg, Frank

    2010-01-01

    The framework of this thesis is the investigation of the generation of proton beams using high-intensity laser pulses. In this work, an experimental method to fully reconstruct laser-accelerated proton beam parameters, called radiochromic film imaging spectroscopy (RIS), was developed. Since the proton beam expansion is a plasma expansion with accompanying electrons, a low-energy electron spectrometer was developed, built and tested to study the electron distribution matching to the proton beam energy distribution. Two experiments were carried out at the VULCAN Petawatt laser with the aim of showing dynamic control and enhancement of proton acceleration using multiple or defocused laser pulses. Irradiating the target with a long pulse, low-intensity laser (10 12 W/cm 2 ) prior to the main pulse (∝ns), an optimum pre-plasma density scale length of 60 μm is generated leading to an enhancement of the maximum proton energy (∝25%), the proton flux (factor of 3) and the beam uniformity. Proton beams were generated more efficiently than previously by driving thinner target foils at a lower intensity over a large area. The optimum condition was a 2 μm foil irradiated with an intensity of 10 19 W/cm 2 onto a 60 μm spot. Laser to proton beam efficiencies of 7.8% have been achieved (2.2% before) - one of the highest conversion efficiencies ever achieved. In the frame of this work, two separate experiments at the TRIDENT laser system have shown that these laser-accelerated proton beams, with their high number of particles in a short pulse duration, are well-suited for creating isochorically heated matter in extreme conditions. Besides the manipulation of the proton beam parameters directly during the generation, the primary aim of this thesis was the capture, control and transport of laser-accelerated proton beams by a solenoidal magnetic field lense for further purpose. In a joint project proposal, the laser and plasma physics group of the Technische Universitat

  6. Simulation of a low energy beam transport line

    International Nuclear Information System (INIS)

    Yang Yao; Liu Zhanwen; Zhang Wenhui; Ma Hongyi; Zhang Xuezhen; Zhao Hongwei; Yao Ze'en

    2012-01-01

    A 2.45 GHz electron cyclotron resonance intense proton source and a low energy beam transport line with dual-Glaser lens were designed and fabricated by Institute of Modern Physics for a compact pulsed hadron source at Tsinghua. The intense proton beams extracted from the ion source are transported through the transport line to match the downstream radio frequency quadrupole accelerator. Particle-in-cell code BEAMPATH was used to carry out the beam transport simulations and optimize the magnetic field structures of the transport line. Emittance growth due to space charge and spherical aberrations of the Glaser lens were studied in both theory and simulation. The results show that narrow beam has smaller aberrations and better beam quality through the transport line. To better match the radio frequency quadrupole accelerator, a shorter transport line is desired with sufficient space charge neutralization. (authors)

  7. Polarized proton beams

    International Nuclear Information System (INIS)

    Roser, T.

    1995-01-01

    The acceleration of polarized proton beams in circular accelerators is complicated by the presence of numerous depolarizing spin resonances. Careful and tedious minimization of polarization loss at each of these resonances allowed acceleration of polarized proton beams up to 22 GeV. It has been the hope that Siberian Snakes, which are local spin rotators inserted into ring accelerators, would eliminate these resonances and allow acceleration of polarized beams with the same ease and efficiency that is now routine for unpolarized beams. First tests at IUCF with a full Siberian Snake showed that the spin dynamics with a Snake can be understood in detail. The author now has results of the first tests of a partial Siberian Snake at the AGS, accelerating polarized protons to an energy of about 25 GeV. These successful tests of storage and acceleration of polarized proton beams open up new possibilities such as stored polarized beams for internal target experiments and high energy polarized proton colliders

  8. Beam-Beam Effects in the SPS Proton-Anti Proton Collider

    CERN Document Server

    Cornelis, K.

    2014-01-01

    During the proton-anti proton collider run several experiments were carried out in order to understand the effect of the beam-beam interaction on backgrounds and lifetimes. In this talk a selection of these experiments will be presented. From these experiments, the importance of relative beam sizes and tune ripple could be demonstrated.

  9. Low energy beam transport system developments

    Energy Technology Data Exchange (ETDEWEB)

    Dudnikov, V., E-mail: vadim@muonsinc.com [Muons, Inc., Batavia, IL 60510 (United States); Han, B.; Stockli, M.; Welton, R. [ORNL, Oak Ridge, TN 37831 (United States); Dudnikova, G. [University of Maryland, College Park, MD 3261 (United States); Institute of Computational Technologies SBRAS, Novosibirsk (Russian Federation)

    2015-04-08

    For high brightness beam production it is important to preserve the brightness in the low energy beam transport system (LEBT) used to transport and match the ion beams to the next stage of acceleration, usually an RFQ. While electrostatic focusing can be problematic for high current beam transport, reliable electrostatic LEBT operation has been demonstrated with H{sup −} beams up to 60 mA. Now, however, it is commonly accepted that an optimal LEBT for high current accelerator applications consists of focusing solenoids with space charge compensation. Two-solenoid LEBTs are successfully used for high current (>100 mA) proton beam transport. Preservation of low emittances (~0.15 π mm-mrad) requires the addition of a heavy gas (Xe, Kr), which causes ~5% of proton loss in a 1 m long LEBT. Similar Xe densities would be required to preserve low emittances of H{sup −} beams, but such gas densities cause unacceptably high H{sup −} beam losses. A short LEBT with only one short solenoid, movable for RFQ matching, can be used for reduced negative ion stripping. A strong electrostatic-focusing LEBT has been successfully adopted for transport of high current H{sup −} beams in the SNS Front End. Some modifications of such electrostatic LEBTs are expected to improve the reliable transport of intense positive and negative ion beams without greatly degrading their low emittances. We concentrate on processes that determine the beam brightness degradation and on their prevention. Proposed improvements to the SNS electrostatic LEBT are discussed.

  10. Proton beam transport experiments with pulsed high-field magnets at the Dresden laser acceleration source Draco

    Energy Technology Data Exchange (ETDEWEB)

    Kroll, Florian; Schramm, Ulrich [Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany); Technische Universitaet Dresden, Dresden (Germany); Kraft, Stephan; Metzkes, Josefine; Schlenvoigt, Hans-Peter; Zeil, Karl [Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany)

    2016-07-01

    Compact laser-driven ion accelerators are a potential alternative to large and expensive conventional accelerators. High-power short-pulse lasers, impinging on e.g. thin metal foils, enable multi-MeV ion acceleration on μm length and fs to ps time scale. The generated ion bunches (typically protons) show unique beam properties, like ultra-high pulse dose. Nevertheless, laser accelerators still require substantial development in reliable beam generation and transport. Recently developed pulsed magnets meet the demands of laser acceleration and open up new research opportunities: We present a pulsed solenoid for effective collection and focusing of laser-accelerated protons that acts as link between fundamental research and application. The solenoid is powered by a capacitor-based pulse generator and can reach a maximum magnetic field of 20 T. It was installed in the target chamber of the Draco laser at HZDR. The transported beam was detected by means of radiochromic film, scintillator and Thomson parabola spectrometer. We present the characterization of the solenoid with regard to future application in radiobiological irradiation studies. Furthermore, a detailed comparison to previous experiments with a similar magnet at the PHELIX laser at GSI, Darmstadt is provided.

  11. Sausage instability in a proton-beam transport through wall-confined plasma channel

    International Nuclear Information System (INIS)

    Yamada, Tetsuo; Masugata, Katsumi; Matsui, Masao; Yatsui, Kiyoshi

    1983-01-01

    An instability observed previously in a 800-keV of proton-beam transport through a wall-confined, z-discharged plasma channel (1-m long) has been identified as a sausage type from measurements made using an image converter campera. Clear evidence of the sausage instability has been obtained from the streak and framing photographs. When the instability grows with time, the wavelength tends to increase. The pinch velocity of the channel has also been measured in a parameter space, which gives reasonable agreement with the existing theory. (author)

  12. Development of an energy selector system for laser-driven proton beam applications

    Energy Technology Data Exchange (ETDEWEB)

    Scuderi, V., E-mail: scuderiv@lns.infn.it [Department of Experimental Program at ELI-Beamlines, Institute of Physics of the ASCR, ELI-Beamlines project, Na Slovance 2, Prague (Czech Republic); Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Bijan Jia, S. [Ferdowsi University of Mashhad, Azadi Square, Mashhad (Iran, Islamic Republic of); Carpinelli, M. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Cirrone, G.A.P. [Department of Experimental Program at ELI-Beamlines, Institute of Physics of the ASCR, ELI-Beamlines project, Na Slovance 2, Prague (Czech Republic); Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Cuttone, G. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Korn, G. [Department of Experimental Program at ELI-Beamlines, Institute of Physics of the ASCR, ELI-Beamlines project, Na Slovance 2, Prague (Czech Republic); Licciardello, T. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Maggiore, M. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Viale dell' Universit 2, Legnaro (Pd) (Italy); Margarone, D. [Department of Experimental Program at ELI-Beamlines, Institute of Physics of the ASCR, ELI-Beamlines project, Na Slovance 2, Prague (Czech Republic); Pisciotta, P.; Romano, F. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Schillaci, F. [Department of Experimental Program at ELI-Beamlines, Institute of Physics of the ASCR, ELI-Beamlines project, Na Slovance 2, Prague (Czech Republic); Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); Stancampiano, C. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania (Italy); and others

    2014-03-11

    Nowadays, laser-driven proton beams generated by the interaction of high power lasers with solid targets represent a fascinating attraction in the field of the new acceleration techniques. These beams can be potentially accelerated up to hundreds of MeV and, therefore, they can represent a promising opportunity for medical applications. Laser-accelerated proton beams typically show high flux (up to 10{sup 11} particles per bunch), very short temporal profile (ps), broad energy spectra and poor reproducibility. In order to overcome these limitations, these beams have be controlled and transported by means of a proper beam handling system. Furthermore, suitable dosimetric diagnostic systems must be developed and tested. In the framework of the ELIMED project, we started to design a dedicated beam transport line and we have developed a first prototype of a beam line key-element: an Energy Selector System (ESS). It is based on permanent dipoles, capable to control and select in energy laser-accelerated proton beams. Monte Carlo simulations and some preliminary experimental tests have been already performed to characterize the device. A calibration of the ESS system with a conventional proton beam will be performed in September at the LNS in Catania. Moreover, an experimental campaign with laser-driven proton beam at the Centre for Plasma Physics, Queens University in Belfast is already scheduled and will be completed within 2014.

  13. Maskless proton beam writing in gallium arsenide

    Energy Technology Data Exchange (ETDEWEB)

    Mistry, P. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom) and Nano-Electronics Centre, Advanced Technology Institute, University of Surrey, Guildford GU2 7XH (United Kingdom)]. E-mail: p.mistry@surrey.ac.uk; Gomez-Morilla, I. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Smith, R.C. [Nano-Electronics Centre, Advanced Technology Institute, University of Surrey, Guildford GU2 7XH (United Kingdom); Thomson, D. [Advanced Technology Institute, University of Surrey, Guildford GU2 7XH (United Kingdom); Grime, G.W. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Webb, R.P. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Gwilliam, R. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Jeynes, C. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Cansell, A. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Merchant, M. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom); Kirkby, K.J. [Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom)

    2007-07-15

    Proton beam writing (PBW) is a direct write technique that employs a focused MeV proton beam which is scanned in a pre-determined pattern over a target material which is subsequently electrochemically etched or chemically developed. By changing the energy of the protons the range of the protons can be changed. The ultimate depth of the structure is determined by the range of the protons in the material and this allows structures to be formed to different depths. PBW has been successfully employed on etchable glasses, polymers and semiconductor materials such as silicon (Si) and gallium arsenide (GaAs). This study reports on PBW in p-type GaAs and compares experimental results with computer simulations using the Atlas (copy right) semiconductor device package from SILVACO. It has already been proven that hole transport is required for the electrochemical etching of GaAs using Tiron (4,5-dihydroxy-m-benzenedisulfonic acid, di-sodium salt). PBW in GaAs results in carrier removal in the irradiated regions and consequently minimal hole transport (in these regions) during electrochemical etching. As a result the irradiated regions are significantly more etch resistant than the non-irradiated regions. This allows high aspect ratio structures to be formed.

  14. Maskless proton beam writing in gallium arsenide

    International Nuclear Information System (INIS)

    Mistry, P.; Gomez-Morilla, I.; Smith, R.C.; Thomson, D.; Grime, G.W.; Webb, R.P.; Gwilliam, R.; Jeynes, C.; Cansell, A.; Merchant, M.; Kirkby, K.J.

    2007-01-01

    Proton beam writing (PBW) is a direct write technique that employs a focused MeV proton beam which is scanned in a pre-determined pattern over a target material which is subsequently electrochemically etched or chemically developed. By changing the energy of the protons the range of the protons can be changed. The ultimate depth of the structure is determined by the range of the protons in the material and this allows structures to be formed to different depths. PBW has been successfully employed on etchable glasses, polymers and semiconductor materials such as silicon (Si) and gallium arsenide (GaAs). This study reports on PBW in p-type GaAs and compares experimental results with computer simulations using the Atlas (copy right) semiconductor device package from SILVACO. It has already been proven that hole transport is required for the electrochemical etching of GaAs using Tiron (4,5-dihydroxy-m-benzenedisulfonic acid, di-sodium salt). PBW in GaAs results in carrier removal in the irradiated regions and consequently minimal hole transport (in these regions) during electrochemical etching. As a result the irradiated regions are significantly more etch resistant than the non-irradiated regions. This allows high aspect ratio structures to be formed

  15. Multigroup and coupled forward-adjoint Monte Carlo calculation efficiencies for secondary neutron doses from proton beams

    International Nuclear Information System (INIS)

    Kelsey IV, Charles T.; Prinja, Anil K.

    2011-01-01

    We evaluate the Monte Carlo calculation efficiency for multigroup transport relative to continuous energy transport using the MCNPX code system to evaluate secondary neutron doses from a proton beam. We consider both fully forward simulation and application of a midway forward adjoint coupling method to the problem. Previously we developed tools for building coupled multigroup proton/neutron cross section libraries and showed consistent results for continuous energy and multigroup proton/neutron transport calculations. We observed that forward multigroup transport could be more efficient than continuous energy. Here we quantify solution efficiency differences for a secondary radiation dose problem characteristic of proton beam therapy problems. We begin by comparing figures of merit for forward multigroup and continuous energy MCNPX transport and find that multigroup is 30 times more efficient. Next we evaluate efficiency gains for coupling out-of-beam adjoint solutions with forward in-beam solutions. We use a variation of a midway forward-adjoint coupling method developed by others for neutral particle transport. Our implementation makes use of the surface source feature in MCNPX and we use spherical harmonic expansions for coupling in angle rather than solid angle binning. The adjoint out-of-beam transport for organs of concern in a phantom or patient can be coupled with numerous forward, continuous energy or multigroup, in-beam perturbations of a therapy beam line configuration. Out-of-beam dose solutions are provided without repeating out-of-beam transport. (author)

  16. Proton transport model in the ionosphere. 2. Influence of magnetic mirroring and collisions on the angular redistribution in a proton beam

    Directory of Open Access Journals (Sweden)

    M. Galand

    1998-10-01

    Full Text Available We investigate the influence of magnetic mirroring and elastic and inelastic scattering on the angular redistribution in a proton/hydrogen beam by using a transport code in comparison with observations. H-emission Doppler profiles viewed in the magnetic zenith exhibit a red-shifted component which is indicative of upward fluxes. In order to determine the origin of this red shift, we evaluate the influence of two angular redistribution sources which are included in our proton/hydrogen transport model. Even though it generates an upward flux, the redistribution due to magnetic mirroring effect is not sufficient to explain the red shift. On the other hand, the collisional angular scattering induces a much more significant red shift in the lower atmosphere. The red shift due to collisions is produced  by <1 -keV protons and is so small as to require an instrumental bandwidth <0.2 nm. This explains the absence of measured upward proton/hydrogen fluxes in the Proton I rocket data because no useable data concerning protons <1 keV are available. At the same time, our model agrees with measured ground-based H-emission Doppler profiles and suggests that previously reported red shift observations were due mostly to instrumental bandwidth broadening of the profile. Our results suggest that Doppler profile measurements with higher spectral resolution may enable us to quantify better the angular scattering in proton aurora.Key words. Auroral ionosphere · Particle precipitation

  17. Self-pinched transport of intense ion beams

    International Nuclear Information System (INIS)

    Ottinger, P.F.; Neri, J.M.; Stephanakis, S.J.

    1999-01-01

    Electron beams with substantial net currents have been routinely propagated in the self-pinched mode for the past two decades. However, as the physics of gas breakdown and beam neutralization is different for ion beams, previous predictions indicated insufficient net current for pinching so that ion beam self-pinched transport (SPT) was assumed impossible. Nevertheless, recent numerical simulations using the IPROP code have suggested that ion SPT is possible. These results have prompted initial experiments to investigate SPT of ion beams. A 100-kA, 1.2-MeV, 3-cm-radius proton beam, generated on the Gamble II pulsed-power accelerator at NRL, has been injected into helium in the 30- to 250-mTorr regime to study this phenomenon. Evidence of self-pinched ion beam transport was observed in the 35- to 80-mTorr SPT pressure window predicted by IPROP. Measured signals from a time- and space-resolved scattered proton diagnostic and a time-integrated Li(Cu) nuclear activation diagnostic, both of which measure protons striking a 10-cm diameter target 50 cm into the transport region, are significantly larger in this pressure window than expected for ballistic transport. These results are consistent with significant self-magnetic fields and self-pinching of the ion beam. On the other hand, time-integrated signals from these same two diagnostics are consistent with ballistic transport at pressures above and below the SPT window. Interferometric electron line-density measurements, acquired during beam injection into the helium gas, show insignificant ionization below 35 mTorr, a rapidly rising ionization fraction with pressure in the SPT window, and a plateau in ionization fraction at about 2% for pressures above 80 mTorr. These and other results are consistent with the physical picture for SPT. IPROP simulations, which closely model the Gamble II experimental conditions, produce results that are in qualitative agreement with the experimental results. The advantages of SPT for

  18. Evaluation of the Induced Activity in Air by the External Proton Beam in the Target Room of the Proton Accelerator Facility of Proton Engineering Frontier Project

    International Nuclear Information System (INIS)

    Lee, Cheol Woo; Lee, Young Ouk; Cho, Young Sik; Ahn, So Hyun

    2007-01-01

    One of the radiological concerns is the worker's exposure level and the concentration of the radionuclides in the air after shutdown, for the safety analysis on the proton accelerator facility. Although, the primary radiation source is the protons accelerated up to design value, all of the radio-nuclide is produced from the secondary neutron and photon induced reaction in air. Because, the protons don't penetrate the acceleration equipment like the DTL tank wall or BTL wall, secondary neutrons or photons are only in the air in the accelerator tunnel building because of the short range of the proton in the materials. But, for the case of the target rooms, external proton beams are occasionally used in the various experiments. When these external proton beams travel through air from the end of the beam transport line to the target, they interact directly with air and produce activation products from the proton induced reaction. The external proton beam will be used in the target rooms in the accelerator facility of the Proton Accelerator Frontier Project (PEFP). In this study, interaction characteristics of the external proton beam with air and induced activity in air from the direct interaction of the proton beam were evaluated

  19. Generation and transport of laser accelerated ion beams

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Peter; Boine-Frankenheim, Oliver [Technische Univ. Darmstadt (Germany); GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); Kornilov, Vladimir; Spaedtke, Peter [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); Collaboration: LIGHT-Collaboration

    2013-07-01

    Currently the LIGHT- Project (Laser Ion Generation, Handling and Transport) is performed at the GSI Helmholtzzentrum fuer Schwerionenforschung GmbH Darmstadt. Within this project, intense proton beams are generated by laser acceleration, using the TNSA mechanism. After the laser acceleration the protons are transported through the beam pipe by a pulsed power solenoid. To study the transport a VORPAL 3D simulation is compared with CST simulation. A criterion as a function of beam parameters was worked out, to rate the importance of space charge. Furthermore, an exemplary comparison of the solenoid with a magnetic quadrupole-triplet was carried out. In the further course of the LIGHT-Project, it is planned to generate ion beams with higher kinetic energies, using ultra-thin targets. The acceleration processes that can appear are: RPA (Radiation Pressure Acceleration) and BOA (Break-Out Afterburner). Therefore the transport of an ion distribution will be studied, as it emerges from a RPA acceleration.

  20. DC proton beam measurements in a single-solenoid low-energy beam transport system

    International Nuclear Information System (INIS)

    Stevens, R.R. Jr.; Schafstall, P.; Schneider, J.D.; Sherman, J.; Zaugg, T.; Taylor, T.

    1994-01-01

    High current, CW proton accelerators are being considered for a number of applications including disposition of nuclear wastes, reduction of fissionable nuclear material inventories, safe production of critical nuclear materials, and energy production. All these applications require the development of high current, reliable, hydrogen ion injectors. In 1986, a program using CW RFQ technology was undertaken at CRL in collaboration with LANL and was continued there until 1993. During this time, an accelerator was built which produced 600 keV, 75 mA and 1,250 keV, 55 mA CW proton beams. The present program at Los Alamos using this accelerator is aimed at continuing the CRL work to demonstrate long-term reliability. In the present work, the authors are seeking to determine the optimal match to and the current limit of the 1,250-keV RFQ. This paper discusses the characterization of the 50 keV beams at the exit of the single-solenoid LEBT and presents both the experimental measurements and the beam simulations done to model this system

  1. Proton Beam Writing

    International Nuclear Information System (INIS)

    Rajta, I.; Szilasi, S.Z.; Csige, I.; Baradacs, E.

    2005-01-01

    Complete text of publication follows. Refractive index depth profile in PMMA due to proton irradiation Proton Beam Writing has been successfully used to create buried channel waveguides in PMMA, which suggested that proton irradiation increases the refractive index. To investigate this effect, PMMA samples were irradiated by 1.7-2.1 MeV proton beam. Spectroscopic Ellipsometry has been used to investigate the depth profile of the refractive index. An increase of the refractive index was observed in the order of 0.01, which is approximately one order of magnitude higher than the detection limit. The highest increase of the refractive index occurs at the end of range, i.e. we found a good correlation with the Bragg curve of the energy loss. Hardness changes in PMMA due to proton beam micromachining As protons penetrate a target material and lose their energy according to the Bragg curve, the energy loss is different at different depths. This causes depth-dependent changes of some physical properties in the target material (e.g. refractive index, hardness). In order to characterize the changes of hardness and other mechanical properties as a function of beam penetration depth, systematic investigations have been performed on PMMA, the most common resist material used in proton beam micromachining. Silicon check valve made by proton beam micromachining The possible application of Proton Beam Micromachining (PBM) has been demonstrated by a few authors for creating 3D Si microstructures. In this work we present alternative methods for the formation of a simple a non-return valve for microfluidic applications. Two different approaches have been applied, in both cases we exploited characteristic features of the PBM technique and the selective formation and dissolution of porous Si over the implantation damaged areas. In the first case we implanted 10 μm thick cantilever-type membrane of the valve normally to the crystal surface and at 30-60 degrees to the sidewalls of the

  2. A beam optics study of the biomedical beam line at a proton therapy facility

    International Nuclear Information System (INIS)

    Yun, Chong Cheoul; Kim, Jong-Won

    2007-01-01

    A biomedical beam line has been designed for the experimental area of a proton therapy facility to deliver mm to sub-mm size beams in the energy range of 20-50 MeV using the TRANSPORT/TURTLE beam optics codes and a newly-written program. The proton therapy facility is equipped with a 230 MeV fixed-energy cyclotron and an energy selection system based on a degrader and slits, so that beam currents available for therapy decrease at lower energies in the therapeutic beam energy range of 70-230 MeV. The new beam line system is composed of an energy-degrader, two slits, and three quadrupole magnets. The minimum beam sizes achievable at the focal point are estimated for the two energies of 50 and 20 MeV. The focused FWHM beam size is approximately 0.3 mm with an expected beam current of 20 pA when the beam energy is reduced to 50 MeV from 100 MeV, and roughly 0.8 mm with a current of 10 pA for a 20 MeV beam

  3. Shielding calculations in support of the Spallation Neutron Source (SNS) proton beam transport system

    International Nuclear Information System (INIS)

    Johnson, Jeffrey O.; Gallmeier, Franz X.; Popova, Irina

    2002-01-01

    Determining the bulk shielding requirements for accelerator environments is generally an easy task compared to analyzing the radiation transport through the complex shield configurations and penetrations typically associated with the detailed Title II design efforts of a facility. Shielding calculations for penetrations in the SNS accelerator environment are presented based on hybrid Monte Carlo and discrete ordinates particle transport methods. This methodology relies on coupling tools that map boundary surface leakage information from the Monte Carlo calculations to boundary sources for one-, two-, and three-dimensional discrete ordinates calculations. The paper will briefly introduce the coupling tools for coupling MCNPX to the one-, two-, and three-dimensional discrete ordinates codes in the DOORS code suite. The paper will briefly present typical applications of these tools in the design of complex shield configurations and penetrations in the SNS proton beam transport system

  4. Sub 100 nm proton beam micromachining: theoretical calculations on resolution limits

    International Nuclear Information System (INIS)

    Kan, J.A. van; Sum, T.C.; Osipowicz, T.; Watt, F.

    2000-01-01

    Proton beam micromachining is a novel direct-write process for the production of three-dimensional (3D) microstructures. A focused beam of MeV protons is scanned in a pre-determined pattern over a suitable resist material (e.g. PMMA or SU-8) and the latent image formed is subsequently developed chemically. In this paper calculations on theoretical resolution limits of proton beam micromachined three-dimensional microstructures are presented. Neglecting the finite beam size, a Monte Carlo ion transport code was used in combination with a theoretical model describing the delta-ray (δ-ray) energy deposition to determine the lateral energy deposition distribution in PMMA resist material. The energy deposition distribution of ion induced secondary electrons (δ-rays) has been parameterized using analytical models. It is assumed that the attainable resolution is limited by a convolution of the spread of the ion beam and energy deposition of the δ-rays

  5. Proton beam monitor chamber calibration

    International Nuclear Information System (INIS)

    Gomà, C; Meer, D; Safai, S; Lorentini, S

    2014-01-01

    The first goal of this paper is to clarify the reference conditions for the reference dosimetry of clinical proton beams. A clear distinction is made between proton beam delivery systems which should be calibrated with a spread-out Bragg peak field and those that should be calibrated with a (pseudo-)monoenergetic proton beam. For the latter, this paper also compares two independent dosimetry techniques to calibrate the beam monitor chambers: absolute dosimetry (of the number of protons exiting the nozzle) with a Faraday cup and reference dosimetry (i.e. determination of the absorbed dose to water under IAEA TRS-398 reference conditions) with an ionization chamber. To compare the two techniques, Monte Carlo simulations were performed to convert dose-to-water to proton fluence. A good agreement was found between the Faraday cup technique and the reference dosimetry with a plane-parallel ionization chamber. The differences—of the order of 3%—were found to be within the uncertainty of the comparison. For cylindrical ionization chambers, however, the agreement was only possible when positioning the effective point of measurement of the chamber at the reference measurement depth—i.e. not complying with IAEA TRS-398 recommendations. In conclusion, for cylindrical ionization chambers, IAEA TRS-398 reference conditions for monoenergetic proton beams led to a systematic error in the determination of the absorbed dose to water, especially relevant for low-energy proton beams. To overcome this problem, the effective point of measurement of cylindrical ionization chambers should be taken into account when positioning the reference point of the chamber. Within the current IAEA TRS-398 recommendations, it seems advisable to use plane-parallel ionization chambers—rather than cylindrical chambers—for the reference dosimetry of pseudo-monoenergetic proton beams. (paper)

  6. Laser accelerated protons captured and transported by a pulse power solenoid

    Directory of Open Access Journals (Sweden)

    T. Burris-Mog

    2011-12-01

    Full Text Available Using a pulse power solenoid, we demonstrate efficient capture of laser accelerated proton beams and the ability to control their large divergence angles and broad energy range. Simulations using measured data for the input parameters give inference into the phase-space and transport efficiencies of the captured proton beams. We conclude with results from a feasibility study of a pulse power compact achromatic gantry concept. Using a scaled target normal sheath acceleration spectrum, we present simulation results of the available spectrum after transport through the gantry.

  7. Transport and matching of low energy space charge dominated beams

    International Nuclear Information System (INIS)

    Pandit, V.S.

    2013-01-01

    The transport and matching of low energy high intensity beams from the ion source to the subsequent accelerating structure are of considerable interest in recent years for variety of applications such as Accelerator driven system (ADSS), transmutation of nuclear waste, spallation neutron sources etc. It is essential to perform detailed simulations with experimentation to predict the beam evolution in the presence of nonlinear self as well as external fields before the design of the next accelerating structure is finalized. In order to study and settle various physics and technical issues related with transport of space charge dominated beams we have developed a 2.45 GHz microwave ion source at VECC which is now delivering more than 10 mA proton beam current at 80 keV. We have successfully transported well collimated 8 mA proton beam through the solenoid based 3 meter long transport line and studied various beam properties. We have also studied the transport of beam through spiral inflector at low beam current ∼ 1mA. In this article we will discuss the beam transport issues and describe a technique for simulation of beam envelopes in presence of linear space charge effects. We use canonical description of the motion of a single particle and then obtain first order differential equations for evolution of the moments of beam ensemble by assuming uniform distribution of the beam. We will also discuss the methodology used in the simulations to understand the observed beam behaviour during transport. (author)

  8. Development of disease animal models using proton beam

    International Nuclear Information System (INIS)

    Nam, K. H.; Kim, E. K.; Kim, H. R.; Seo, Y. W.

    2010-03-01

    To identify proper proton beam dose for mutant mouse development, total 7 times of proton beam were performed. There are too low incidence of mutation in pup mouse which were derived embryos radiated by 1Gy proton beam. Some mutation could be identified in pup mice which were derived embryos radiated by 1.5-2.5Gy proton beam. Mouse embryos irradiated with 1-10Gy of proton beam were inhibited in their in vitro development to 2 cell stage. There was no pups born from embryos which were irradiated with proton beam over 3 Gy. Early mouse development were greatly inhibited by proton beam irradiation of over 10Gy when cultured in vitro. In conclusion, it is efficient to irradiate mouse embryo with 1.5-2.5Gy of proton beam for development of mutant mice

  9. The clinical case for proton beam therapy

    International Nuclear Information System (INIS)

    Foote, Robert L; Haddock, Michael G; Yan, Elizabeth; Laack, Nadia N; Arndt, Carola A S

    2012-01-01

    Over the past 20 years, several proton beam treatment programs have been implemented throughout the United States. Increasingly, the number of new programs under development is growing. Proton beam therapy has the potential for improving tumor control and survival through dose escalation. It also has potential for reducing harm to normal organs through dose reduction. However, proton beam therapy is more costly than conventional x-ray therapy. This increased cost may be offset by improved function, improved quality of life, and reduced costs related to treating the late effects of therapy. Clinical research opportunities are abundant to determine which patients will gain the most benefit from proton beam therapy. We review the clinical case for proton beam therapy. Proton beam therapy is a technically advanced and promising form of radiation therapy

  10. Proton-beam radiation therapy dosimetry standardization

    International Nuclear Information System (INIS)

    Gall, K.P.

    1995-01-01

    Beams of protons have been used for radiation therapy applications for over 40 years. In the last decade the number of facilities treating patients and the total number of patients being treated has begun go grow rapidly. Due to the limited and experimental nature of the early programs, dosimetry protocols tended to be locally defined. With the publication of the AAPM Task Group 20 report open-quotes Protocol for Dosimetry of Heavy Charged Particlesclose quotes and the open-quotes European Code of Practice for Proton-Beam Dosimetryclose quotes the practice of determining dose in proton-beam therapy was somewhat unified. The ICRU has also recently commissioned a report on recommendations for proton-beam dosimetry. There have been three main methods of determining proton dose; the Faraday cup technique, the ionization chamber technique, and the calorimeter technique. For practical reasons the ionization chamber technique has become the most widely used. However, due to large errors in basic parameters (e.g., W-value) is also has a large uncertainty for absolute dose. It has been proposed that the development of water calorimeter absorbed dose standards would reduce the uncertainty in absolute proton dose as well as the relative dose between megavoltage X-ray beams and proton beams. The advantages and disadvantages are discussed

  11. The clinical case for proton beam therapy

    Directory of Open Access Journals (Sweden)

    Foote Robert L

    2012-10-01

    Full Text Available Abstract Over the past 20 years, several proton beam treatment programs have been implemented throughout the United States. Increasingly, the number of new programs under development is growing. Proton beam therapy has the potential for improving tumor control and survival through dose escalation. It also has potential for reducing harm to normal organs through dose reduction. However, proton beam therapy is more costly than conventional x-ray therapy. This increased cost may be offset by improved function, improved quality of life, and reduced costs related to treating the late effects of therapy. Clinical research opportunities are abundant to determine which patients will gain the most benefit from proton beam therapy. We review the clinical case for proton beam therapy. Summary sentence Proton beam therapy is a technically advanced and promising form of radiation therapy.

  12. Polarized proton beams since the ZGS

    International Nuclear Information System (INIS)

    Krisch, A.D.

    1994-01-01

    The author discusses research involving polarized proton beams since the ZGS's demise. He begins by reminding the attendee that in 1973 the ZGS accelerated the world's first high energy polarized proton beam; all in attendance at this meeting can be proud of this accomplishment. A few ZGS polarized proton beam experiments were done in the early 1970's; then from about 1976 until 1 October 1979, the majority of the ZGS running time was polarized running. A great deal of fundamental physics was done with the polarized beam when the ZGS ran as a dedicated polarized proton beam from about Fall 1977 until it shut down on 1 October 1979. The newly created polarization enthusiats then dispersed; some spread polarized seeds al over the world by polarizing beams elsewhere; some wound up running the High Energy and SSC programs at DOE

  13. Light ion beam transport research at NRL

    International Nuclear Information System (INIS)

    Hinshelwood, D.D.; Boller, J.R.; Cooperstein, G.

    1996-01-01

    Transport of light ion beams through low-pressure background gas is under investigation at NRL in support of the light-ion ICF program at Sandia National Laboratories. Scaling experiments and the field solver/orbit code ATHETA have been used to design and construct a focusing, extraction applied-B diode for transport experiments. An active anode source has been developed to provide a high proton fraction in the ion beam and a fast ion turn-on time. A very sensitive Zeeman diagnostic is being developed to determine the net current distribution in the beam/transport system. Both analytical and numerical techniques using several codes are being applied to transport modeling, leading to the capability of full system studies. (author). 1 tab., 5 figs., 10 refs

  14. Light ion beam transport research at NRL

    Energy Technology Data Exchange (ETDEWEB)

    Hinshelwood, D D; Boller, J R; Cooperstein, G [Naval Research Lab., Washington, DC (United States). Plasma Physics Div.; and others

    1997-12-31

    Transport of light ion beams through low-pressure background gas is under investigation at NRL in support of the light-ion ICF program at Sandia National Laboratories. Scaling experiments and the field solver/orbit code ATHETA have been used to design and construct a focusing, extraction applied-B diode for transport experiments. An active anode source has been developed to provide a high proton fraction in the ion beam and a fast ion turn-on time. A very sensitive Zeeman diagnostic is being developed to determine the net current distribution in the beam/transport system. Both analytical and numerical techniques using several codes are being applied to transport modeling, leading to the capability of full system studies. (author). 1 tab., 5 figs., 10 refs.

  15. External proton and Li beams

    International Nuclear Information System (INIS)

    Schuff, Juan A.; Burlon, Alejandro A.; Debray, Mario E.; Kesque, Jose M.; Kreiner, Andres J.; Stoliar, Pablo A.; Naab, Fabian; Ozafran, Mabel J.; Vazquez, Monica E.; Perez de la Hoz, A.; Somacal, Hector; Valda, Alejandro; Canevas, S.; Ruffolo, M.; Tasat, D.R.; Muhlmann, M. C.

    2000-01-01

    In the frame of a feasibility study to introduce proton therapy in Argentina in a collaborative agreement between the Physics and Radiobiology Departments of the National Atomic Energy Commission or Argentina and the Centre de Protontherapie de Orsay, France, external proton and Li beams were produced at the TANDAR accelerator in Buenos Aires. The specific aim of this work was to start radiobiology studies on cell cultures and small laboratory animals. In particular we seek to determine here the relative biological effectiveness, RBE, for proton and Li beams as a function of energy for different tumor and normal cell lines. The 24 MeV proton beam was diffused using a 25 μm gold foil and extracted through a Kapton window to obtain a homogeneous field (constant to 95%) of about 7 cm in diameter. Measurements were carried out with quasi-monoenergetic beams (of 20.2 ± 0.07 MeV, 2.9 ± 0.10 MeV y 1.5 ± 0.1 MeV for protons and 21.4 ± 0.4 MeV for Lithium). Proton fluence and Bragg peaks were measured. The dose delivered in each case was monitored on-line with a calibrated transmission ionization chamber. Three cell lines PDV, PDVC 57 and V 79 (as a reference) were irradiated with γ-rays, proton and lithium beams with linear energy transfer (LET) from 2 to 100 keV/μm. RBE values in the range of 1.2-5.9 were obtained. In addition preliminary studies on chromosomal aberrations and viability of alveolar macrophages were carried out. (author)

  16. Proton beam therapy how protons are revolutionizing cancer treatment

    CERN Document Server

    Yajnik, Santosh

    2013-01-01

    Proton beam therapy is an emerging technology with promise of revolutionizing the treatment of cancer. While nearly half of all patients diagnosed with cancer in the US receive radiation therapy, the majority is delivered via electron accelerators, where photons are used to irradiate cancerous tissue. Because of the physical properties of photon beams, photons may deposit energy along their entire path length through the body. On the other hand, a proton beam directed at a tumor travels in a straight trajectory towards its target, gives off most of its energy at a defined depth called the Bragg peak, and then stops. While photons often deposit more energy within the healthy tissues of the body than within the cancer itself, protons can deposit most of their cancer-killing energy within the area of the tumor. As a result, in the properly selected patients, proton beam therapy has the ability to improve cure rates by increasing the dose delivered to the tumor and simultaneously reduce side-effects by decreasing...

  17. Off-axis dose equivalent due to secondary neutrons from uniform scanning proton beams during proton radiotherapy

    Science.gov (United States)

    Islam, M. R.; Collums, T. L.; Zheng, Y.; Monson, J.; Benton, E. R.

    2013-11-01

    The production of secondary neutrons is an undesirable byproduct of proton therapy and it is important to quantify the contribution from secondary neutrons to patient dose received outside the treatment volume. The purpose of this study is to investigate the off-axis dose equivalent from secondary neutrons experimentally using CR-39 plastic nuclear track detectors (PNTD) at ProCure Proton Therapy Center, Oklahoma City, OK. In this experiment, we placed several layers of CR-39 PNTD laterally outside the treatment volume inside a phantom and in air at various depths and angles with respect to the primary beam axis. Three different proton beams with max energies of 78, 162 and 226 MeV and 4 cm modulation width, a 5 cm diameter brass aperture, and a small snout located 38 cm from isocenter were used for the entire experiment. Monte Carlo simulations were also performed based on the experimental setup using a simplified snout configuration and the FLUKA Monte Carlo radiation transport code. The measured ratio of secondary neutron dose equivalent to therapeutic primary proton dose (H/D) ranged from 0.3 ± 0.08 mSv Gy-1 for 78 MeV proton beam to 37.4 ± 2.42 mSv Gy-1 for 226 MeV proton beam. Both experiment and simulation showed a similar decreasing trend in dose equivalent with distance to the central axis and the magnitude varied by a factor of about 2 in most locations. H/D was found to increase as the energy of the primary proton beam increased and higher H/D was observed at 135° compared to 45° and 90°. The overall higher H/D in air indicates the predominance of external neutrons produced in the nozzle rather than inside the body.

  18. Off-axis dose equivalent due to secondary neutrons from uniform scanning proton beams during proton radiotherapy

    International Nuclear Information System (INIS)

    Islam, M R; Collums, T L; Monson, J; Benton, E R; Zheng, Y

    2013-01-01

    The production of secondary neutrons is an undesirable byproduct of proton therapy and it is important to quantify the contribution from secondary neutrons to patient dose received outside the treatment volume. The purpose of this study is to investigate the off-axis dose equivalent from secondary neutrons experimentally using CR-39 plastic nuclear track detectors (PNTD) at ProCure Proton Therapy Center, Oklahoma City, OK. In this experiment, we placed several layers of CR-39 PNTD laterally outside the treatment volume inside a phantom and in air at various depths and angles with respect to the primary beam axis. Three different proton beams with max energies of 78, 162 and 226 MeV and 4 cm modulation width, a 5 cm diameter brass aperture, and a small snout located 38 cm from isocenter were used for the entire experiment. Monte Carlo simulations were also performed based on the experimental setup using a simplified snout configuration and the FLUKA Monte Carlo radiation transport code. The measured ratio of secondary neutron dose equivalent to therapeutic primary proton dose (H/D) ranged from 0.3 ± 0.08 mSv Gy −1  for 78 MeV proton beam to 37.4 ± 2.42 mSv Gy −1  for 226 MeV proton beam. Both experiment and simulation showed a similar decreasing trend in dose equivalent with distance to the central axis and the magnitude varied by a factor of about 2 in most locations. H/D was found to increase as the energy of the primary proton beam increased and higher H/D was observed at 135° compared to 45° and 90°. The overall higher H/D in air indicates the predominance of external neutrons produced in the nozzle rather than inside the body. (paper)

  19. The development of MEMS device packaging technology using proton beam

    International Nuclear Information System (INIS)

    Hyeon, J. W.; Kong, Y. J.; Kim, E. H.; Kim, H. S.; No, S. J.

    2006-05-01

    atmospheric pressure using 8, 13 MeV of proton beam energy, current ranging from 1 μA to 20 μA. which proton beam energy is transported to maximum in bonding interface when thickness of pyrex glass is 0.5, 1 mm. The size of Si wafer and the pyrex glass were 1 cm x 1 cm respectively. Thickness were 650 μm-(Si) and 1 mm-(Pyrex). In our experiments, pyrex glass to Si wafer bonding are successfully achieved without extra heating or electric fields

  20. Laser accelerated protons captured and transported by a pulse power solenoid

    OpenAIRE

    Burris-Mog, T.; Harres, K.; Zielbauer, B.; Bagnoud, V.; Herrmannsdoerfer, T.; Roth, M.; Cowan, T. E.; Nürnberg, F.; Busold, S.; Bussmann, M.; Deppert, O.; Hoffmeister, G.; Joost, M.; Sobiella, M.; Tauschwitz, A.

    2011-01-01

    Using a pulse power solenoid, we demonstrate efficient capture of laser accelerated proton beams and the ability to control their large divergence angles and broad energy range. Simulations using measured data for the input parameters give inference into the phase-space and transport efficiencies of the captured proton beams. We conclude with results from a feasibility study of a pulse power compact achromatic gantry concept. Using a scaled target normal sheath acceleration spectrum, we prese...

  1. Proton beam characterization by proton-induced acoustic emission: simulation studies

    International Nuclear Information System (INIS)

    Jones, K C; Witztum, A; Avery, S; Sehgal, C M

    2014-01-01

    Due to their Bragg peak, proton beams are capable of delivering a targeted dose of radiation to a narrow volume, but range uncertainties currently limit their accuracy. One promising beam characterization technique, protoacoustic range verification, measures the acoustic emission generated by the proton beam. We simulated the pressure waves generated by proton radiation passing through water. We observed that the proton-induced acoustic signal consists of two peaks, labeled α and γ, with two originating sources. The α acoustic peak is generated by the pre-Bragg peak heated region whereas the source of the γ acoustic peak is the proton Bragg peak. The arrival time of the α and γ peaks at a transducer reveals the distance from the beam propagation axis and Bragg peak center, respectively. The maximum pressure is not observed directly above the Bragg peak due to interference of the acoustic signals. Range verification based on the arrival times is shown to be more effective than determining the Bragg peak position based on pressure amplitudes. The temporal width of the α and γ peaks are linearly proportional to the beam diameter and Bragg peak width, respectively. The temporal separation between compression and rarefaction peaks is proportional to the spill time width. The pressure wave expected from a spread out Bragg peak dose is characterized. The simulations also show that acoustic monitoring can verify the proton beam dose distribution and range by characterizing the Bragg peak position to within ∼1 mm. (paper)

  2. Laser Compton polarimetry of proton beams

    International Nuclear Information System (INIS)

    Stillman, A.

    1995-01-01

    A need exists for non-destructive polarization measurements of the polarized proton beams in the AGS and, in the future, in RHIC. One way to make such measurements is to scatter photons from the polarized beams. Until now, such measurements were impossible because of the extremely low Compton scattering cross section from protons. Modern lasers now can provide enough photons per laser pulse not only to scatter from proton beams but also, at least in RHIC, to analyze their polarization

  3. Evolution of a beam dynamics model for the transport line in a proton therapy facility

    Science.gov (United States)

    Rizzoglio, V.; Adelmann, A.; Baumgarten, C.; Frey, M.; Gerbershagen, A.; Meer, D.; Schippers, J. M.

    2017-12-01

    During the conceptual design of an accelerator or beamline, first-order beam dynamics models are essential for studying beam properties. However, they can only produce approximate results. During commissioning, these approximate results are compared to measurements, which will rarely coincide if the model does not include the relevant physics. It is therefore essential that this linear model is extended to include higher-order effects. In this paper, the effects of particle-matter interaction have been included in the model of the transport lines in the proton therapy facility at the Paul Scherrer Institut (PSI) in Switzerland. The first-order models of these beamlines provide an approximated estimation of beam size, energy loss and transmission. To improve the performance of the facility, a more precise model was required and has been developed with opal (Object Oriented Parallel Accelerator Library), a multiparticle open source beam dynamics code. In opal, the Monte Carlo simulations of Coulomb scattering and energy loss are performed seamless with the particle tracking. Beside the linear optics, the influence of the passive elements (e.g., degrader, collimators, scattering foils, and air gaps) on the beam emittance and energy spread can be analyzed in the new model. This allows for a significantly improved precision in the prediction of beam transmission and beam properties. The accuracy of the opal model has been confirmed by numerous measurements.

  4. Confinement of a high current proton beam in a linear induction accelerator

    International Nuclear Information System (INIS)

    Kerslick, G.S.; Roth, I.S.; Golkowski, C.; Ivers, J.D.; Nation, J.A.

    1987-01-01

    A 1 MeV, 6 kA, 50 ns annular proton beam has been generated in a two stage induction linac. Several confinement systems designed to allow propagation through multiple acceleration stages have been studied. In the first, the beam is injected through a half cusp into a 1.4 T solenoidal magnetic field. In the second system the beam is generated in a full cusp diode. The third system discussed relies on collective confinement of the protons by the space charge of the neutralizing electrons. This is in contrast to the previously described systems which rely on magnetic confinement. A comparison between the three methods of transport is made

  5. Isochoric heating of DT fuels through PW-laser-produced proton beams

    International Nuclear Information System (INIS)

    Maynard, G.; Barriga-Carrasco, M.D.

    2005-01-01

    Laser Proton Source (LPS) can generate short bunch of energetic protons with a nearly zero initial emittance. It is thus expected that LPS can deposit a very high density of energy inside dense matter, in particular, in the context of fast ignition of an inertial fusion target. We investigate here one of the factors that can limit the density of deposited energy. It concerns the transverse diffusion, occurring during the transport between the LPS and DT. As the rear surface of LPS should be efficiently protected, the proton along its path has to interact with a substantial amount of high-Z material. Therefore the induced transverse dispersion can become significant. The transport of the proton beam inside a plasma target is calculated using a numerical code, which main features are presented

  6. Isochoric heating of DT fuels through PW-laser-produced proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Maynard, G. [Laboratoire de Physique des Gaz et des Pasmas, CNRS UMR8578, bat. 210, Universite Paris XI, F-91405, Orsay (France)]. E-mail: gilles.maynard@pgp.u-psud.fr; Barriga-Carrasco, M.D. [Laboratoire de Physique des Gaz et des Pasmas, CNRS UMR8578, bat. 210, Universite Paris XI, F-91405, Orsay (France)

    2005-05-21

    Laser Proton Source (LPS) can generate short bunch of energetic protons with a nearly zero initial emittance. It is thus expected that LPS can deposit a very high density of energy inside dense matter, in particular, in the context of fast ignition of an inertial fusion target. We investigate here one of the factors that can limit the density of deposited energy. It concerns the transverse diffusion, occurring during the transport between the LPS and DT. As the rear surface of LPS should be efficiently protected, the proton along its path has to interact with a substantial amount of high-Z material. Therefore the induced transverse dispersion can become significant. The transport of the proton beam inside a plasma target is calculated using a numerical code, which main features are presented.

  7. An online, energy-resolving beam profile detector for laser-driven proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Metzkes, J.; Rehwald, M.; Obst, L.; Schramm, U. [Helmholtz-Zentrum Dresden–Rossendorf (HZDR), Bautzner Landstr. 400, 01328 Dresden (Germany); Technische Universität Dresden, 01062 Dresden (Germany); Zeil, K.; Kraft, S. D.; Sobiella, M.; Schlenvoigt, H.-P. [Helmholtz-Zentrum Dresden–Rossendorf (HZDR), Bautzner Landstr. 400, 01328 Dresden (Germany); Karsch, L. [OncoRay-National Center for Radiation Research in Oncology, Technische Universität Dresden, 01307 Dresden (Germany)

    2016-08-15

    In this paper, a scintillator-based online beam profile detector for the characterization of laser-driven proton beams is presented. Using a pixelated matrix with varying absorber thicknesses, the proton beam is spatially resolved in two dimensions and simultaneously energy-resolved. A thin plastic scintillator placed behind the absorber and read out by a CCD camera is used as the active detector material. The spatial detector resolution reaches down to ∼4 mm and the detector can resolve proton beam profiles for up to 9 proton threshold energies. With these detector design parameters, the spatial characteristics of the proton distribution and its cut-off energy can be analyzed online and on-shot under vacuum conditions. The paper discusses the detector design, its characterization and calibration at a conventional proton source, as well as the first detector application at a laser-driven proton source.

  8. Design Study for Pulsed Proton Beam Generation

    Directory of Open Access Journals (Sweden)

    Han-Sung Kim

    2016-02-01

    Full Text Available Fast neutrons with a broad energy spectrum, with which it is possible to evaluate nuclear data for various research fields such as medical applications and the development of fusion reactors, can be generated by irradiating proton beams on target materials such as beryllium. To generate short-pulse proton beam, we adopted a deflector and slit system. In a simple deflector with slit system, most of the proton beam is blocked by the slit, especially when the beam pulse width is short. Therefore, the available beam current is very low, which results in low neutron flux. In this study, we proposed beam modulation using a buncher cavity to increase the available beam current. The ideal field pattern for the buncher cavity is sawtooth. To make the field pattern similar to a sawtooth waveform, a multiharmonic buncher was adopted. The design process for the multiharmonic buncher includes a beam dynamics calculation and three-dimensional electromagnetic simulation. In addition to the system design for pulsed proton generation, a test bench with a microwave ion source is under preparation to test the performance of the system. The design study results concerning the pulsed proton beam generation and the test bench preparation with some preliminary test results are presented in this paper.

  9. Overview of the APT high-energy beam transport and beam expanders

    International Nuclear Information System (INIS)

    Shafer, R.E.; Blind, B.; Gray, E.R.

    1997-01-01

    The APT high energy beam transport (HEBT) and beam expanders convey the 1700-MeV, 100-mA cw proton beam from the linac to the tritium target/blanket assembly, or a tuning beam stop. The HEBT includes extensive beam diagnostics, collimators, and beam jitter correction, to monitor and control the 170-MW beam prior to expansion. A zero-degree beamline conveys the beam to the beam stop, and an achromatic bend conveys the beam to the tritium production target. Nonlinear beam expanders make use of higher-order multipole magnets and dithering dipoles to expand the beam to a uniform-density, 16-cm wide by 160-cm high rectangular profile on the tritium-production target. The overall optics design will be reviewed, and beam simulations will be presented

  10. Electron density measurements during ion beam transport on Gamble II

    International Nuclear Information System (INIS)

    Weber, B.V.; Hinshelwood, D.D.; Neri, J.M.; Ottinger, P.F.; Rose, D.V.; Stephanakis, S.J.; Young, F.C.

    1999-01-01

    High-sensitivity laser interferometry was used to measure the electron density created when an intense proton beam (100 kA, 1 MeV, 50 ns) from the Gamble II generator was transported through low-pressure gas as part of a project investigating Self-Pinched Transport (SPT) of intense ion beams. This measurement is non-perturbing and sufficiently quantitative to allow benchmarking of codes (particularly IPROP) used to model beam-gas interaction and ion-beam transport. Very high phase sensitivity is required for this measurement. For example, a 100-kA, 1-MeV, 10-cm-radius proton beam with uniform current density has a line-integrated proton density equal to n b L = 3 x 10 13 cm -2 . An equal electron line-density, n e L = n b L, (expected for transport in vacuum) will be detected as a phase shift of the 1.064 microm laser beam of only 0.05degree, or an optical path change of 1.4 x 10 -4 waves (about the size of a hydrogen atom). The time-history of the line-integrated electron density, measured across a diameter of the transport chamber at 43 cm from the input aperture, starts with the proton arrival time and decays differently depending on the gas pressure. The gas conditions included vacuum (10 -4 Torr air), 30 to 220 mTorr He, and 1 Torr air. The measured densities vary by three orders of magnitude, from 10 13 to 10 16 cm -2 for the range of gas pressures investigated. In vacuum, the measured electron densities indicate only co-moving electrons (n e L approximately n b L). In He, when the gas pressure is sufficient for ionization by beam particles and SPT is observed, n e L increases to about 10 n b L. At even higher pressures where electrons contribute to ionization, even higher electron densities are observed with an ionization fraction of about 2%. The diagnostic technique as used on the SPT experiment will be described and a summary of the results will be given. The measurements are in reasonable agreement with theoretical predictions from the IPROP code

  11. IKOR - An isochronous pulse compressor ring for proton beams

    International Nuclear Information System (INIS)

    Schaffer, G.

    1981-06-01

    This report contains the results of a study carried out for an isochronous compressor ring IKOR which compresses the 500 μs linac macropulses into pulses of 0.68 μs length. Its basic component is a ring magnet with alternating gradient and separated functions. Due to the isochronous operation, an rf system can be avoided which otherwise would be necessary in order to maintain a void in the circulating beam for the purpose of ejection. Injection is performed by charge exchange. The H - beam of the accelerator is first converted into a H 0 beam by stripping off one electron by a high gradient magnet placed in the transfer channel. Subsequently, the beam is converted into a proton beam by removing the remaining electron through a stripping foil in the ring. IKOR will be filled in 658 turns. Immediately after filling, the beam is ejected in a single turn via a kicker and a septum magnet and is transported to the spallation target. Because of the high intensity of 2.7 x 10 14 protons per pulse and, secondly, due to the high repetition rate of 100 Hz, beam dynamics and radiation protection aspects dominate the design and are, for this reason, treated in detail. (orig.)

  12. Proton-beam energy analyzer

    International Nuclear Information System (INIS)

    Belan, V.N.; Bolotin, L.I.; Kiselev, V.A.; Linnik, A.F.; Uskov, V.V.

    1989-01-01

    The authors describe a magnetic analyzer for measurement of proton-beam energy in the range from 100 keV to 25 MeV. The beam is deflected in a uniform transverse magnetic field and is registered by photographing a scintillation screen. The energy spectrum of the beam is constructed by microphotometry of the photographic film

  13. The measurement of proton stopping power using proton-cone-beam computed tomography

    International Nuclear Information System (INIS)

    Zygmanski, P.; Rabin, M.S.Z.; Gall, K.P.; Rosenthal, S.J.

    2000-01-01

    A cone-beam computed tomography (CT) system utilizing a proton beam has been developed and tested. The cone beam is produced by scattering a 160 MeV proton beam with a modifier that results in a signal in the detector system, which decreases monotonically with depth in the medium. The detector system consists of a Gd 2 O 2 S:Tb intensifying screen viewed by a cooled CCD camera. The Feldkamp-Davis-Kress cone-beam reconstruction algorithm is applied to the projection data to obtain the CT voxel data representing proton stopping power. The system described is capable of reconstructing data over a 16x16x16cm 3 volume into 512x512x512 voxels. A spatial and contrast resolution phantom was scanned to determine the performance of the system. Spatial resolution is significantly degraded by multiple Coulomb scattering effects. Comparison of the reconstructed proton CT values with x-ray CT derived proton stopping powers shows that there may be some advantage to obtaining stopping powers directly with proton CT. The system described suggests a possible practical method of obtaining this measurement in vivo. (author)

  14. Bunching and phase focusing of laser generated proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Schumacher, Dennis; Hofmann, Ingo; Blazevic, Abel; Deppert, Oliver [GSI Helmholtzzentrum fuer Schwerionenforschung (Germany); Busold, Simon; Roth, Markus; Boine-Frankenheim, Oliver [TU Darmstadt (Germany); Brabetz, Christian [Universitaet Frankfurt, Frankfurt am Main (Germany); Zielbauer, Bernhard [HI Jena (Germany); Collaboration: LIGHT-Collaboration

    2013-07-01

    Laser accelerated proton beams can reach very high intensities and very low emittances. Therefore they are suitable as ion sources for many applications. One is the coupling into common ion accelerator structures to replace pre accelerators that are used so far. The LIGHT (Laser Ion Generation, Handling and Transport) collaboration has been founded to develop ion optics and targets and optimize laser parameter to make this coupling most efficient. In a first step a short pulse beam line for the PHELIX-laser at GSI to the experiment site Z6 has been build in order to laser accelerate protons here. In a second step a pulsed solenoid has been established to collimate the divergent ion beam. In a third step this collimated beam will be coupled into a bunching unit, which consists of a spiral resonator with three gaps which leads to an overall acceleration voltage of 1 MV. With this cavity it is not only possible to avoid the broadening of the pulse, but also to phase focus it. This talk presents also the progress towards the operation of the spiral resonator as buncher for a laser accelerated ion beam e.g. simulations, tests and performance data and shows the next steps of the beam shaping efforts.

  15. External proton and Li beams; Haces externos de protones y litios

    Energy Technology Data Exchange (ETDEWEB)

    Schuff, Juan A; Burlon, Alejandro A; Debray, Mario E; Kesque, Jose M; Kreiner, Andres J; Stoliar, Pablo A; Naab, Fabian; Ozafran, Mabel J; Vazquez, Monica E [Comision Nacional de Energia Atomica, General San Martin (Argentina). Dept. de Fisica; Policastro, Lucia L; Duran, Hebe; Molinari, Beatriz L; O' Connor, Silvia E; Saint-Martin, Maria L.G.; Palmieri, Monica; Bernaola, Omar A; Opezzo, Oscar J [Comision Nacional de Energia Atomica, General San Martin (Argentina). Dept. de Radiobiologia; Mazal, A; Favaudon, F; Henry, Y [Institut Curie, 75 - Paris (France); Perez de la Hoz, A.; Somacal, Hector; Valda, Alejandro; Canevas, S; Ruffolo, M; Tasat, D R [Universidad Nacional de General San Martin, Villa Ballester (Argentina). Escuela de Ciencia y Tecnologia; Davidson, Miguel; Davidson, Jorge [Buenos Aires Univ. (Argentina). Dept. de Fisica; Delacroix, S; Nauraye, C; Brune, E; Gautier, C; Habrand, J L [Centre de Protontherapie, 91 - Orsay (France); Muhlmann, M C [Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Buenos Aires (Argentina)

    2000-07-01

    In the frame of a feasibility study to introduce proton therapy in Argentina in a collaborative agreement between the Physics and Radiobiology Departments of the National Atomic Energy Commission or Argentina and the Centre de Protontherapie de Orsay, France, external proton and Li beams were produced at the TANDAR accelerator in Buenos Aires. The specific aim of this work was to start radiobiology studies on cell cultures and small laboratory animals. In particular we seek to determine here the relative biological effectiveness, RBE, for proton and Li beams as a function of energy for different tumor and normal cell lines. The 24 MeV proton beam was diffused using a 25 {mu}m gold foil and extracted through a Kapton window to obtain a homogeneous field (constant to 95%) of about 7 cm in diameter. Measurements were carried out with quasi-monoenergetic beams (of 20.2 {+-} 0.07 MeV, 2.9 {+-} 0.10 MeV y 1.5 {+-} 0.1 MeV for protons and 21.4 {+-} 0.4 MeV for Lithium). Proton fluence and Bragg peaks were measured. The dose delivered in each case was monitored on-line with a calibrated transmission ionization chamber. Three cell lines PDV, PDVC 57 and V 79 (as a reference) were irradiated with {gamma}-rays, proton and lithium beams with linear energy transfer (LET) from 2 to 100 keV/{mu}m. RBE values in the range of 1.2-5.9 were obtained. In addition preliminary studies on chromosomal aberrations and viability of alveolar macrophages were carried out. (author)

  16. Studies on beam extraction from the 1 GeV proton accumulator ring

    International Nuclear Information System (INIS)

    Goyal, Pradeep Kumar; Sharma, Amalendu; Kumar, Vinit; Ghodke, A.D.

    2015-01-01

    For the proposed Indian Spallation Neutron Source (ISNS), a 1 GeV proton Accumulator Ring (AR) is presently being designed at RRCAT. Two optics configurations of AR, namely FODO and Hybrid lattices are under consideration. Each lattice configuration has four superperiods. In this paper, preliminary studies on beam extraction from AR are presented for both the optics configurations. The extraction system will be accommodated in one of the long dispersion free straight sections. Bunch length of the proton beam in AR is 700 ns, and the revolution time of the bunch in AR is 1 ms. This leaves a gap of ∼300 ns for bunch extraction. The proton bunch will be extracted to Ring to Target Beam Transport (RTBT) line, with the help of fast kicker and septum magnets. In this paper, we present the details of the beam extraction scheme with suitable number of kicker magnets, and find out their optimal location and strength. Estimation of field error tolerances for kicker magnets is also presented. (author)

  17. Defocusing beam line design for an irradiation facility at the TAEA SANAEM Proton Accelerator Facility

    CERN Document Server

    Gencer, A.; Efthymiopoulos, I.; Yiğitoğlu, M.

    2016-01-01

    Electronic components must be tested to ensure reliable performance in high radiation environments such as Hi-Limu LHC and space. We propose a defocusing beam line to perform proton irradiation tests in Turkey. The Turkish Atomic Energy Authority SANAEM Proton Accelerator Facility was inaugurated in May 2012 for radioisotope production. The facility has also an R&D room for research purposes. The accelerator produces protons with 30 MeV kinetic energy and the beam current is variable between View the MathML source10μA and View the MathML source1.2mA. The beam kinetic energy is suitable for irradiation tests, however the beam current is high and therefore the flux must be lowered. We plan to build a defocusing beam line (DBL) in order to enlarge the beam size, reduce the flux to match the required specifications for the irradiation tests. Current design includes the beam transport and the final focusing magnets to blow up the beam. Scattering foils and a collimator is placed for the reduction of the beam ...

  18. High-field superconducting window-frame beam-transport magnets

    International Nuclear Information System (INIS)

    Allinger, J.; Carroll, A.; Danby, G.; DeVito, B.; Jackson, J.; Leonhardt, W.; Prodell, A.; Skarita, J.

    1982-01-01

    The window-frame design for high-field superconducting beam-transport magnets was first applied to two, 2-m-long, 4-T modules of an 8 0 bending magent which has operated for nine years in the primary proton beam line at the Brookhaven National Laboratory Alternating Gradient Synchrotron (AGS). The design of two 1.5-m long, 7.6-cm cold-bore superconducting windowframe magnets, described in this paper, intended for the external proton beam transport system at the AGS incorporated evolutionary changes. These magnets generated a maximum aperture field of 6.8 T with a peak field in the dipole coil of 7.1 T. Measured fields are very accurate and are compared to values calculated using the computer programs LINDA and POISSON. Results of quench-propagation studies demonstrate the excellent thermal stability of the magnets. The magnets quench safely without energy extraction at a maximum current density, J = 130 kA/cm 2 in the superconductor, corresponding to J = 57.6 kA/cm 2 overall the conductor at B = 6.7 T

  19. Polarizing a stored proton beam by spin-flip?

    International Nuclear Information System (INIS)

    Oellers, Dieter Gerd Christian

    2010-01-01

    The present thesis discusses the extraction of the electron-proton spin-flip cross-section. The experimental setup, the data analysis and the results are pictured in detail. The proton is described by a QCD-based parton model. In leading twist three functions are needed. The quark distribution, the helicity distribution and the transversity distribution. While the first two are well-known, the transversity distribution is largely unknown. A self-sufficient measurement of the transversity is possible in double polarized proton-antiproton scattering. This rises the need of a polarized antiproton beam. So far spin filtering is the only tested method to produce a polarized proton beam, which may be capable to hold also for antiprotons. In-situ polarization build-up of a stored beam either by selective removal or by spin-flip of a spin-(1)/(2) beam is mathematically described. A high spin-flip cross-section would create an effective method to produce a polarized antiproton beam by polarized positrons. Prompted by conflicting calculations, a measurement of the spin-flip cross-section in low-energy electron-proton scattering was carried out. This experiment uses the electron beam of the electron cooler at COSY as an electron target. The depolarization of the stored proton beam is detected. An overview of the experiment is followed by detailed descriptions of the cycle setup, of the electron target and the ANKE silicon tracking telescopes acting as a beam polarimeter. Elastic protondeuteron scattering is the analyzing reaction. The event selection is depicted and the beam polarization is calculated. Upper limits of the two electron-proton spin-flip cross-sections σ parallel and σ perpendicular to are deduced using the likelihood method. (orig.)

  20. Proton beam writing of passive waveguides in PMMA

    International Nuclear Information System (INIS)

    Sum, T.C.; Bettiol, A.A.; Seng, H.L.; Rajta, I.; Kan, J.A. van; Watt, F.

    2003-01-01

    Symmetric y-branch buried channel waveguides in poly-methylmethacrylate (PMMA) were fabricated by proton beam writing using a focused sub-micron beam of 1.5 and 2.0 MeV protons with a dose ranging from 25 to 160 nC/mm 2 (i.e. ∼1.6 x 10 13 to 1.0 x 10 14 particles/cm 2 ) and beam currents of approximately 5-10 pA. The proton beam modifies the PMMA (i.e. changes the refractive index), forming buried channel waveguides near the end of range. The buried channel waveguides were end-coupled with monochromatic light (633 nm) and the transmitted intensity profiles were measured, indicating an intensity distribution of 0.45/0.55 from each branch. The surface compaction of the PMMA as a result of the irradiation for doses up to 160 nC/mm 2 was also investigated. From these investigations, the optimal fabrication conditions for proton beam writing of PMMA were established. Waveguides of arbitrary design can be easily fabricated using proton beam writing, making the technique ideal for the rapid prototyping of optical circuits

  1. Amorphous track modelling of luminescence detector efficiency in proton and carbon beams

    DEFF Research Database (Denmark)

    Greilich, Steffen; Grzanka, Leszek; Bassler, Niels

    assumptions in a variety of detectors. The library also includes simple particle transportation or can be interfaced to external transport codes. We applied our code to RL and OSL data from fiber-coupled Al2O3:C-detectors in a proton (nominal energies 10 MeV to 60 MeV) and a carbon beam (270 MeV/u). Results...

  2. Beam heating in solar flares - Electrons or protons?

    International Nuclear Information System (INIS)

    Brown, J.C.; Karlicky, M.; Mackinnon, A.L.; Van Den Oord, G.H.J.

    1990-01-01

    The current status of electron and proton beam models as candidates for the impulsive phase heating of solar flares is discussed in relation to observational constants and theoretical difficulties. It is concluded that, while the electron beam model for flare heating still faces theoretical and observational problems, the problems faced by low and high energy proton beam models are no less serious, and there are facets of proton models which have not yet been studied. At the present, the electron beam model remains the most viable and best developed of heating model candidates. 58 refs

  3. Polarizing a stored proton beam by spin-flip?

    Energy Technology Data Exchange (ETDEWEB)

    Oellers, Dieter Gerd Christian

    2010-04-15

    The present thesis discusses the extraction of the electron-proton spin-flip cross-section. The experimental setup, the data analysis and the results are pictured in detail. The proton is described by a QCD-based parton model. In leading twist three functions are needed. The quark distribution, the helicity distribution and the transversity distribution. While the first two are well-known, the transversity distribution is largely unknown. A self-sufficient measurement of the transversity is possible in double polarized proton-antiproton scattering. This rises the need of a polarized antiproton beam. So far spin filtering is the only tested method to produce a polarized proton beam, which may be capable to hold also for antiprotons. In-situ polarization build-up of a stored beam either by selective removal or by spin-flip of a spin-(1)/(2) beam is mathematically described. A high spin-flip cross-section would create an effective method to produce a polarized antiproton beam by polarized positrons. Prompted by conflicting calculations, a measurement of the spin-flip cross-section in low-energy electron-proton scattering was carried out. This experiment uses the electron beam of the electron cooler at COSY as an electron target. The depolarization of the stored proton beam is detected. An overview of the experiment is followed by detailed descriptions of the cycle setup, of the electron target and the ANKE silicon tracking telescopes acting as a beam polarimeter. Elastic protondeuteron scattering is the analyzing reaction. The event selection is depicted and the beam polarization is calculated. Upper limits of the two electron-proton spin-flip cross-sections {sigma} {sub parallel} and {sigma} {sub perpendicular} {sub to} are deduced using the likelihood method. (orig.)

  4. Protons and how they are transported by proton pumps

    DEFF Research Database (Denmark)

    Buch-Pedersen, Morten Jeppe; Pedersen, Bjørn Panyella; Veierskov, Bjarke

    2008-01-01

    The very high mobility of protons in aqueous solutions demands special features of membrane proton transporters to sustain efficient yet regulated proton transport across biological membranes. By the use of the chemical energy of ATP, plasma-membrane-embedded ATPases extrude protons from cells...... of plants and fungi to generate electrochemical proton gradients. The recently published crystal structure of a plasma membrane H(+)-ATPase contributes to our knowledge about the mechanism of these essential enzymes. Taking the biochemical and structural data together, we are now able to describe the basic...... molecular components that allow the plasma membrane proton H(+)-ATPase to carry out proton transport against large membrane potentials. When divergent proton pumps such as the plasma membrane H(+)-ATPase, bacteriorhodopsin, and F(O)F(1) ATP synthase are compared, unifying mechanistic premises for biological...

  5. Protons and how they are transported by proton pumps

    DEFF Research Database (Denmark)

    Buch-Pedersen, Morten Jeppe; Pedersen, Bjørn Panyella; Nissen, Poul

    2008-01-01

    molecular components that allow the plasma membrane proton H(+)-ATPase to carry out proton transport against large membrane potentials. When divergent proton pumps such as the plasma membrane H(+)-ATPase, bacteriorhodopsin, and F(O)F(1) ATP synthase are compared, unifying mechanistic premises for biological...... proton pumps emerge. Most notably, the minimal pumping apparatus of all pumps consists of a central proton acceptor/donor, a positively charged residue to control pK (a) changes of the proton acceptor/donor, and bound water molecules to facilitate rapid proton transport along proton wires....

  6. Pulsed high field magnets. An efficient way of shaping laser accelerated proton beams for application

    Energy Technology Data Exchange (ETDEWEB)

    Kroll, Florian; Schramm, Ulrich [Helmholtz-Zentrum Dresden - Rossendorf, 01328 Dresden (Germany); Technische Universitaet Dresden, 01062 Dresden (Germany); Bagnoud, Vincent; Blazevic, Abel; Busold, Simon [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Helmholtz Institut Jena, 07734 Jena (Germany); Brabetz, Christian; Schumacher, Dennis [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Deppert, Oliver; Jahn, Diana; Roth, Markus [Technische Universitaet Darmstadt, 64289 Darmstadt (Germany); Karsch, Leonhard; Masood, Umar [OncoRay-National Center for Radiation Research in Oncology, TU Dresden, 01307 Dresden (Germany); Kraft, Stephan [Helmholtz-Zentrum Dresden - Rossendorf, 01328 Dresden (Germany)

    2015-07-01

    Compact laser-driven proton accelerators are a potential alternative to complex, expensive conventional accelerators, enabling unique beam properties, like ultra-high pulse dose. Nevertheless, they still require substantial development in reliable beam generation and transport. We present experimental studies on capture, shape and transport of laser and conventionally accelerated protons via pulsed high-field magnets. These magnets, common research tools in the fields of solid state physics, have been adapted to meet the demands of laser acceleration experiments.Our work distinctively shows that pulsed magnet technology makes laser acceleration more suitable for application and can facilitate compact and efficient accelerators, e.g. for material research as well as medical and biological purposes.

  7. Parameters of medical proton beam of JINR and study on its medical use

    International Nuclear Information System (INIS)

    Dzhelepov, V.P.; Abazov, V.M.; Komarov, V.I.; Kuz'min, E.S.; Reshetnikov, G.P.; Savchenko, O.V.; Cherevatenko, E.P.; Ruderman, A.I.; Astrakhan, B.V.; Vajnberg, M.Sh.

    1975-01-01

    Experiments are described on irradiation of deep-lying tumours in man with a proton beam on the Dubna synchrocyclotron. A proton beam with an energy of 680 MeV is focused on a braking filter of liquid paraffin or water, 1.5 m thick. The slowed-down protons are cleared of impurity particles by the magnetic field and are transported for about 30 m to clinical premises located behind a 2 m concrete shield. The total intensity and maximum density of the proton flux with an energy of 185 MeV are about 10 9 s -1 and 5x10 7 cm -2 s -1 , respectively. The results of dose measurements showed that the maximum dose rate is about 300 rad/min at a proton energy of 185 MeV, and about 120 rad/min at 90 MeV. The contribution of the secondary particles to the dose distribution is about 10%. Patients can be irradiated either in the static regime, or in the rotation regime, when the patient rotates about a vertical axis passing through the tumour centre. While the patient is rotating, all the changes in the thickness of the tissues through which the beam passes before it reaches the tumour, are automatically compensated by a change in the thickness of the water absorber installed in front of the patient. Irradiations of patients with surface tumours showed that the proton beam parameters and the technical equipment of the systems meet the medical requirements

  8. Medipix2 as a tool for proton beam characterization

    Science.gov (United States)

    Bisogni, M. G.; Cirrone, G. A. P.; Cuttone, G.; Del Guerra, A.; Lojacono, P.; Piliero, M. A.; Romano, F.; Rosso, V.; Sipala, V.; Stefanini, A.

    2009-08-01

    Proton therapy is a technique used to deliver a highly accurate and effective dose for the treatment of a variety of tumor diseases. The possibility to have an instrument able to give online information could reduce the time necessary to characterize the proton beam. To this aim we propose a detection system for online proton beam characterization based on the Medipix2 chip. Medipix2 is a detection system based on a single event counter read-out chip, bump-bonded to silicon pixel detector. The read-out chip is a matrix of 256×256 cells, 55×55 μm 2 each. To demonstrate the capabilities of Medipix2 as a proton detector, we have used a 62 MeV flux proton beam at the CATANA beam line of the LNS-INFN laboratory. The measurements performed confirmed the good imaging performances of the Medipix2 system also for the characterization of proton beams.

  9. Medipix2 as a tool for proton beam characterization

    Energy Technology Data Exchange (ETDEWEB)

    Bisogni, M.G. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy); Cirrone, G.A.P.; Cuttone, G. [INFN Laboratori Nazionali del Sud, Catania (Italy); Del Guerra, A. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy); Lojacono, P. [INFN Laboratori Nazionali del Sud, Catania (Italy); Piliero, M.A. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy); Romano, F. [INFN Laboratori Nazionali del Sud, Catania (Italy); Rosso, V. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy)], E-mail: valeria.rosso@pi.infn.it; Sipala, V. [Department of Physics and Astronomy, University of Catania and INFN Sezione di Catania, Catania (Italy); Stefanini, A. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy)

    2009-08-01

    Proton therapy is a technique used to deliver a highly accurate and effective dose for the treatment of a variety of tumor diseases. The possibility to have an instrument able to give online information could reduce the time necessary to characterize the proton beam. To this aim we propose a detection system for online proton beam characterization based on the Medipix2 chip. Medipix2 is a detection system based on a single event counter read-out chip, bump-bonded to silicon pixel detector. The read-out chip is a matrix of 256x256 cells, 55x55 {mu}m{sup 2} each. To demonstrate the capabilities of Medipix2 as a proton detector, we have used a 62 MeV flux proton beam at the CATANA beam line of the LNS-INFN laboratory. The measurements performed confirmed the good imaging performances of the Medipix2 system also for the characterization of proton beams.

  10. Medipix2 as a tool for proton beam characterization

    International Nuclear Information System (INIS)

    Bisogni, M.G.; Cirrone, G.A.P.; Cuttone, G.; Del Guerra, A.; Lojacono, P.; Piliero, M.A.; Romano, F.; Rosso, V.; Sipala, V.; Stefanini, A.

    2009-01-01

    Proton therapy is a technique used to deliver a highly accurate and effective dose for the treatment of a variety of tumor diseases. The possibility to have an instrument able to give online information could reduce the time necessary to characterize the proton beam. To this aim we propose a detection system for online proton beam characterization based on the Medipix2 chip. Medipix2 is a detection system based on a single event counter read-out chip, bump-bonded to silicon pixel detector. The read-out chip is a matrix of 256x256 cells, 55x55 μm 2 each. To demonstrate the capabilities of Medipix2 as a proton detector, we have used a 62 MeV flux proton beam at the CATANA beam line of the LNS-INFN laboratory. The measurements performed confirmed the good imaging performances of the Medipix2 system also for the characterization of proton beams.

  11. Hyperon beams as a source of polarized protons

    International Nuclear Information System (INIS)

    Underwood, D.G.

    1978-01-01

    A high energy polarized proton beam which would utilize lambda decays as a source of polarized protons was proposed. We discuss the operation of such a beam and related physics experiments. 12 references

  12. Experience at the Los Alamos Meson Physics Facility with the use of alloy Inconel 718 as an enclosure for a beam degrader and as a proton beam entry window

    International Nuclear Information System (INIS)

    Sommer, W.F.; Ferguson, P.D.; Brown, R.D.; Cedillo, C.M.; Zimmerman, E.

    1994-01-01

    Operation of the Los Alamos Meson Physics Facility (LAMPF) began in 1972 and continues at present. An injector delivers protons to a 0.8 kin long linear accelerator which produces a particle energy of 800 MeV; the protons are then transported to a variety of experimental areas. The proton beam is transported in a vacuum tube, controlled and bent by electromagnets. The highest intensity beam, at a maximum level of 1 mA, is delivered to the experimental area designated as Area A. At the end of the experimental area, the beam is transported through an interface between beamline vacuum and one atmosphere air pressure. This interface is made of metal and is generally referred to as a beam entry window. At LAMPF, after the beam has exited the vacuum tube, it becomes incident on a number of experiments or ''targets.'' These include capsules for radiation damage studies, a beam ''degrader'' for the long-term neutrino experiment, and as many nine targets in the Isotope Production (IP) stringer system used to produce medically significant isotopes. Following the IP system is a beam stop used for the purpose its name implies. The beam stop also contains a beam entry window, whose purpose is to separate the 250 psig water cooling environment from I atmosphere of air. The beam entry window, the beam degrader, and the beam stop window are made of alloy Inconel 718, have endured a lengthy irradiation service time at LAMPF, and are the subject of this report

  13. SU-E-T-321: The Effects of a Dynamic Collimation System On Proton Pencil Beams to Improve Lateral Tissue Sparing in Spot Scanned Proton Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Hill, P; Wang, D; Flynn, R; Hyer, D [University Of Iowa, Iowa City, IA (United States)

    2014-06-01

    Purpose: To evaluate the lateral beam penumbra in pencil beam scanning proton therapy delivered using a dynamic collimator device capable of trimming a portion of the primary beam in close proximity to the patient. Methods: Monte Carlo simulations of pencil beams were performed using MCNPX. Each simulation transported a 125 MeV proton pencil beam through a range shifter, past acollimator, and into a water phantom. Two parameters were varied among the simulations, the source beam size (sigma in air from 3 to 9 mm), and the position of the edge of the collimator (placed from 0 to 30 mm from the central axis of the beam). Proton flux was tallied at the phantom surface to determine the effective beam sizefor all combinations of source beam size and collimator edge position. Results: Quantifying beam size at the phantom surface provides a useful measure tocompare performance among varying source beam sizes and collimation conditions. For arelatively large source beam size (9 mm) entering the range shifter, sigma at thesurface was found to be 10 mm without collimation versus 4 mm with collimation. Additionally, sigma at the surface achievable with collimation was found to be smallerthan for any uncollimated beam, even for very small source beam sizes. Finally, thelateral penumbra achievable with collimation was determined to be largely independentof the source beam size. Conclusion: Collimation can significantly reduce proton pencil beam lateral penumbra.Given the known dosimetric disadvantages resulting from large beam spot sizes,employing a dynamic collimation system can significantly improve lateral tissuesparing in spot-scanned dose distributions.

  14. Fan beam intensity modulated proton therapy

    Science.gov (United States)

    Hill, Patrick M.

    A fan beam proton therapy is developed which delivers intensity modulated proton therapy using distal edge tracking. The system may be retrofit onto existing proton therapy gantries without alterations to infrastructure in order to improve treatments through intensity modulation. A novel range and intensity modulation system is designed using acrylic leaves that are inserted or retracted from subsections of the fan beam. Leaf thicknesses are chosen in a base-2 system and motivated in a binary manner. Dose spots from individual beam channels range between 1 and 5 cm. Integrated collimators attempting to limit crosstalk among beam channels are investigated, but found to be inferior to uncollimated beam channel modulators. A treatment planning system performing data manipulation in MATLAB and dose calculation in MCNPX is developed. Beamlet dose is calculated on patient CT data and a fan beam source is manually defined to produce accurate results. An energy deposition tally follows the CT grid, allowing straightforward registration of dose and image data. Simulations of beam channels assume that a beam channel either delivers dose to a distal edge spot or is intensity modulated. A final calculation is performed separately to determine the deliverable dose accounting for all sources of scatter. Treatment plans investigate the effects that varying system parameters have on dose distributions. Beam channel apertures may be as large as 20 mm because the sharp distal falloff characteristic of proton dose provides sufficient intensity modulation to meet dose objectives, even in the presence of coarse lateral resolution. Dose conformity suffers only when treatments are delivered from less than 10 angles. Jaw widths of 1--2 cm produce comparable dose distributions, but a jaw width of 4 cm produces unacceptable target coverage when maintaining critical structure avoidance. Treatment time for a prostate delivery is estimated to be on the order of 10 minutes. Neutron production

  15. Proton Fast Ignition

    International Nuclear Information System (INIS)

    Key, M H; Freeman, R R; Hatchett, S P; MacKinnon, A J; Patel, P K; Snavely, R A; Stephens, R B

    2006-04-01

    Fast ignition (FI) by a laser generated ballistically focused proton beam is a more recently proposed alternative to the original concept of FI by a laser generated beam of relativistic electrons. It has potential advantages in less complex energy transport into dense plasma. Recent successful target heating experiments motivate further investigation of the feasibility of proton fast ignition. The concept, the physics and characteristics of the proton beams, the recent experimental work on focusing of the beams and heating of solid targets and the overall prospects for proton FI are discussed

  16. Splitting of high power, cw proton beams

    Directory of Open Access Journals (Sweden)

    Alberto Facco

    2007-09-01

    Full Text Available A simple method for splitting a high power, continuous wave (cw proton beam in two or more branches with low losses has been developed in the framework of the EURISOL (European Isotope Separation On-Line Radioactive Ion Beam Facility design study. The aim of the system is to deliver up to 4 MW of H^{-} beam to the main radioactive ion beam production target, and up to 100 kW of proton beams to three more targets, simultaneously. A three-step method is used, which includes magnetic neutralization of a fraction of the main H^{-} beam, magnetic splitting of H^{-} and H^{0}, and stripping of H^{0} to H^{+}. The method allows slow raising and individual fine adjustment of the beam intensity in each branch.

  17. Compensation techniques in NIRS proton beam radiotherapy

    International Nuclear Information System (INIS)

    Akanuma, A.; Majima, H.; Furukawa, S.

    1982-01-01

    Proton beam has the dose distribution advantage in radiation therapy, although it has little advantage in biological effects. One of the best advantages is its sharp fall off of dose after the peak. With proton beam, therefore, the dose can be given just to cover a target volume and potentially no dose is delivered thereafter in the beam direction. To utilize this advantage, bolus techniques in conjunction with CT scanning are employed in NIRS proton beam radiation therapy planning. A patient receives CT scanning first so that the target volume can be clearly marked and the radiation direction and fixation method can be determined. At the same time bolus dimensions are calculated. The bolus frames are made with dental paraffin sheets according to the dimensions. The paraffin frame is replaced with dental resin. Alginate (a dental impression material with favorable physical density and skin surface contact) is now employed for the bolus material. With fixation device and bolus on, which are constructed individually, the patient receives CT scanning again prior to a proton beam treatment in order to prove the devices are suitable. Alginate has to be poured into the frame right before each treatments. Further investigations are required to find better bolus materials and easier construction methods

  18. Compensation techniques in NIRS proton beam radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Akanuma, A. (Univ. of Tokyo, Japan); Majima, H.; Furukawa, S.

    1982-09-01

    Proton beam has the dose distribution advantage in radiation therapy, although it has little advantage in biological effects. One of the best advantages is its sharp fall off of dose after the peak. With proton beam, therefore, the dose can be given just to cover a target volume and potentially no dose is delivered thereafter in the beam direction. To utilize this advantage, bolus techniques in conjunction with CT scanning are employed in NIRS proton beam radiation therapy planning. A patient receives CT scanning first so that the target volume can be clearly marked and the radiation direction and fixation method can be determined. At the same time bolus dimensions are calculated. The bolus frames are made with dental paraffin sheets according to the dimensions. The paraffin frame is replaced with dental resin. Alginate (a dental impression material with favorable physical density and skin surface contact) is now employed for the bolus material. With fixation device and bolus on, which are constructed individually, the patient receives CT scanning again prior to a proton beam treatment in order to prove the devices are suitable. Alginate has to be poured into the frame right before each treatments. Further investigations are required to find better bolus materials and easier construction methods.

  19. Defocusing beam line design for an irradiation facility at the TAEA SANAEM Proton Accelerator Facility

    Science.gov (United States)

    Gencer, A.; Demirköz, B.; Efthymiopoulos, I.; Yiğitoğlu, M.

    2016-07-01

    Electronic components must be tested to ensure reliable performance in high radiation environments such as Hi-Limu LHC and space. We propose a defocusing beam line to perform proton irradiation tests in Turkey. The Turkish Atomic Energy Authority SANAEM Proton Accelerator Facility was inaugurated in May 2012 for radioisotope production. The facility has also an R&D room for research purposes. The accelerator produces protons with 30 MeV kinetic energy and the beam current is variable between 10 μA and 1.2 mA. The beam kinetic energy is suitable for irradiation tests, however the beam current is high and therefore the flux must be lowered. We plan to build a defocusing beam line (DBL) in order to enlarge the beam size, reduce the flux to match the required specifications for the irradiation tests. Current design includes the beam transport and the final focusing magnets to blow up the beam. Scattering foils and a collimator is placed for the reduction of the beam flux. The DBL is designed to provide fluxes between 107 p /cm2 / s and 109 p /cm2 / s for performing irradiation tests in an area of 15.4 cm × 21.5 cm. The facility will be the first irradiation facility of its kind in Turkey.

  20. Proton beam characterization in the experimental room of the Trento Proton Therapy facility

    Science.gov (United States)

    Tommasino, F.; Rovituso, M.; Fabiano, S.; Piffer, S.; Manea, C.; Lorentini, S.; Lanzone, S.; Wang, Z.; Pasini, M.; Burger, W. J.; La Tessa, C.; Scifoni, E.; Schwarz, M.; Durante, M.

    2017-10-01

    As proton therapy is becoming an established treatment methodology for cancer patients, the number of proton centres is gradually growing worldwide. The economical effort for building these facilities is motivated by the clinical aspects, but might be also supported by the potential relevance for the research community. Experiments with high-energy protons are needed not only for medical physics applications, but represent also an essential part of activities dedicated to detector development, space research, radiation hardness tests, as well as of fundamental research in nuclear and particle physics. Here we present the characterization of the beam line installed in the experimental room of the Trento Proton Therapy Centre (Italy). Measurements of beam spot size and envelope, range verification and proton flux were performed in the energy range between 70 and 228 MeV. Methods for reducing the proton flux from typical treatments values of 106-109 particles/s down to 101-105 particles/s were also investigated. These data confirm that a proton beam produced in a clinical centre build by a commercial company can be exploited for a broad spectrum of experimental activities. The results presented here will be used as a reference for future experiments.

  1. Dynamic control of laser driven proton beams by exploiting self-generated, ultrashort electromagnetic pulses

    Energy Technology Data Exchange (ETDEWEB)

    Kar, S., E-mail: s.kar@qub.ac.uk; Ahmed, H.; Nersisyan, G.; Hanton, F.; Naughton, K.; Lewis, C. L. S.; Borghesi, M. [Centre for Plasma Physics, School of Mathematics and Physics, Queen' s University Belfast, Belfast BT7 1NN (United Kingdom); Brauckmann, S.; Giesecke, A. L.; Willi, O. [Institut für Laser-und Plasmaphysik, Heinrich-Heine-Universität, Düsseldorf (Germany)

    2016-05-15

    As part of the ultrafast charge dynamics initiated by high intensity laser irradiations of solid targets, high amplitude EM pulses propagate away from the interaction point and are transported along any stalks and wires attached to the target. The propagation of these high amplitude pulses along a thin wire connected to a laser irradiated target was diagnosed via the proton radiography technique, measuring a pulse duration of ∼20 ps and a pulse velocity close to the speed of light. The strong electric field associated with the EM pulse can be exploited for controlling dynamically the proton beams produced from a laser-driven source. Chromatic divergence control of broadband laser driven protons (upto 75% reduction in divergence of >5 MeV protons) was obtained by winding the supporting wire around the proton beam axis to create a helical coil structure. In addition to providing focussing and energy selection, the technique has the potential to post-accelerate the transiting protons by the longitudinal component of the curved electric field lines produced by the helical coil lens.

  2. Proton GE/GM from beam-target asymmetry

    International Nuclear Information System (INIS)

    Mark Jones; Aram Aghalaryan; Abdellah Ahmidouch; Razmik Asaturyan; Frederic Bloch; Werner Boeglin; Peter Bosted; Cedric Carasco; Roger Carlini; Jinseok Cha; Jian-Ping Chen; Michael Christy; Leon Cole; Luminita Coman; Donald Crabb; Samuel Danagoulian; Donal Day; James Dunne; Mostafa Elaasar; Rolf Ent; Howard Fenker; Emil Frlez; David Gaskell; Liping Gan; Javier Gomez; Bitao Hu; Juerg Jourdan; Christopher Keith; Cynthia Keppel; Mahbubul Khandaker; Andreas Klein; Laird Kramer; Yongguang Liang; Jechiel Lichtenstadt; Richard Lindgren; David Mack; Paul McKee; Dustin McNulty; David Meekins; Hamlet Mkrtchyan; Rakhsha Nasseripour; Maria-Ioana Niculescu; Kristoff Normand; Blaine Norum; Dinko Pocanic; Yelena Prok; Brian Raue; Joerg Reinhold; Julie Roche; Daniela Rohe; Oscar Rondon-Aramayo; Nikolai Savvinov; Bradley Sawatzky; Mikell Seely; Ingo Sick; Karl Slifer; C. Smith; Gregory Smith; S. Stepanyan; Liguang Tang; Shigeyuki Tajima; Giuseppe Testa; William Vulcan; Kebin Wang; Glen Warren; Frank Wesselmann; Stephen Wood; Chen Yan; Lulin Yuan; Junho Yun; Markus Zeier; Hong Guo Zhu

    2006-01-01

    The ratio of the proton's electric to magnetic form factor, G E /G M , can be extracted in elastic electron-proton scattering by measuring either cross sections, beam-target asymmetry or recoil polarization. Separate determinations of G E /G M by cross sections and recoil polarization observables disagree for Q 2 > 1 (GeV/c) 2 . Measurement by a third technique might uncover an unknown systematic error in either of the previous measurements. The beam-target asymmetry has been measured for elastic electron-proton scattering at Q 2 = 1.51 (GeV/c) 2 for target spin orientation aligned perpendicular to the beam momentum direction. This is the largest Q 2 at which G E /G M has been determined by a beam-target asymmetry experiment. The result, μG E /G M = 0.884 +/- 0.027 +/- 0.029, is compared to previous world data

  3. Acceleration of polarized proton beams

    International Nuclear Information System (INIS)

    Roser, T.

    1998-01-01

    The acceleration of polarized beams in circular accelerators is complicated by the numerous depolarizing spin resonances. Using a partial Siberian snake and a rf dipole that ensure stable adiabatic spin motion during acceleration has made it possible to accelerate polarized protons to 25 GeV at the Brookhaven AGS. Full Siberian snakes are being developed for RHIC to make the acceleration of polarized protons to 250 GeV possible. A similar scheme is being studied for the 800 GeV HERA proton accelerator

  4. The Beam Profile Monitoring System for the CERN IRRAD Proton Facility

    CERN Document Server

    Ravotti, F; Glaser, M; Matli, E; Pezzullo, G; Gan, K K; Kagan, H; Smith, S; Warner, J D

    2017-01-01

    GeV/c proton beam is used. During beam steering and irradiation, the intensity and the transverse profile of the proton beam are monitored online with custom-made Beam Profile Monitor (BPM) devices. In this work, we present the design and the architecture of the IRRAD BPM system, some results on its performance with the proton beam, as well as its planned grades.

  5. Absolute measurements methods for proton beam dosimetry

    International Nuclear Information System (INIS)

    Laitano, R.F.

    1998-01-01

    A widespread interest in improving proton beam characteristics and related dosimetry became apparent in the recent years, even if the advantages of protons in radiotherapy were pointed out since 1946. The early treatments by proton beams were made for a long time on a small number of patients in very few accelerators sharing their use with nuclear-physics experiments. The first proton accelerator totally dedicated to radiotherapy was established just in 1990 at the Loma Linda Medical Center in the USA. A further reason of the slowly growing use of protons for therapy in the early years, was the lack of adequate means for accurate localization of the treatment volume. The potentialities of protons in imparting a largest part of their energy to very small volumes became exploitable only after the established clinical use of accurate imaging techniques such as based on CT, NMR, PET, etc

  6. Simulation and modeling of the Gamble II self-pinched ion beam transport experiment

    International Nuclear Information System (INIS)

    Rose, D.V.; Ottinger, P.F.; Hinshelwood, D.D.

    1999-01-01

    Progress in numerical simulations and modeling of the self-pinched ion beam transport experiment at the Naval Research Laboratory (NRL) is reviewed. In the experiment, a 1.2-MeV, 100-kA proton beam enters a 1-m long, transport region filled with a low pressure gas (30--250 mTorr helium, or 1 Torr air). The time-dependent velocity distribution function of the injected ion beam is determined from an orbit code that uses a pinch-reflex ion diode model and the measured voltage and current from this diode on the Gamble II generator at NRL. This distribution function is used as the beam input condition for numerical simulations carried out using the hybrid particle-in-cell code IPROP. Results of the simulations will be described, and detailed comparisons will be made with various measurements, including line-integrated electron-density, proton-fluence, and beam radial-profile measurements. As observed in the experiment, the simulations show evidence of self-pinching for helium pressures between 35 and 80 mTorr. Simulations and measurements in 1 Torr air show ballistic transport. The relevance of these results to ion-driven inertial confinement fusion will be discussed

  7. Proton-proton colliding beam facility ISABELLE

    International Nuclear Information System (INIS)

    Hahn, H.

    1980-01-01

    This paper attempts to present the status of the ISABELLE construction project, which has the objective of building a 400 + 400 GeV proton colliding beam facility. The major technical features of the superconducting accelerators with their projected performance are described. Progress made so far, difficulties encountered, and the program until completion in 1986 is briefly reviewed

  8. Design study of low-energy beam transport for multi-charge beams at RAON

    Science.gov (United States)

    Bahng, Jungbae; Qiang, Ji; Kim, Eun-San

    2015-12-01

    The Rare isotope Accelerator Of Newness (RAON) at the Rare Isotope Science Project (RISP) is being designed to simultaneously accelerate beams with multiple charge states. It includes a driver superconducting (SC) linac for producing 200 MeV/u and 400 kW continuous wave (CW) heavy ion beams from protons to uranium. The RAON consists of a few electron cyclotron resonance ion sources, a low-energy beam transport (LEBT) system, a CW 81.25 MHz, 500 keV/u radio frequency quadrupole (RFQ) accelerator, a medium-energy beam transport system, the SC linac, and a charge-stripper system. The LEBT system for the RISP accelerator facility consists of a high-voltage platform, two 90° dipoles, a multi-harmonic buncher (MHB), solenoids, electrostatic quadrupoles, a velocity equalizer, and a diagnostic system. The ECR ion sources are located on a high-voltage platform to reach an initial beam energy of 10 keV/u. After extraction, the ion beam is transported through the LEBT system to the RFQ accelerator. The generated charge states are selected by an achromatic bending system and then bunched by the MHB in the LEBT system. The MHB is used to achieve a small longitudinal emittance in the RFQ by generating a sawtooth wave with three harmonics. In this paper, we present the results and issues of the beam dynamics of the LEBT system.

  9. Design study of low-energy beam transport for multi-charge beams at RAON

    Energy Technology Data Exchange (ETDEWEB)

    Bahng, Jungbae [Department of Physics, Kyungpook National University, Daegu 41566 (Korea, Republic of); Qiang, Ji [Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Kim, Eun-San, E-mail: eskim1@korea.ac.kr [Department of Accelerator Science, Graduate School, Korea University Sejong Campus, Sejong 30019 (Korea, Republic of)

    2015-12-21

    The Rare isotope Accelerator Of Newness (RAON) at the Rare Isotope Science Project (RISP) is being designed to simultaneously accelerate beams with multiple charge states. It includes a driver superconducting (SC) linac for producing 200 MeV/u and 400 kW continuous wave (CW) heavy ion beams from protons to uranium. The RAON consists of a few electron cyclotron resonance ion sources, a low-energy beam transport (LEBT) system, a CW 81.25 MHz, 500 keV/u radio frequency quadrupole (RFQ) accelerator, a medium-energy beam transport system, the SC linac, and a charge-stripper system. The LEBT system for the RISP accelerator facility consists of a high-voltage platform, two 90° dipoles, a multi-harmonic buncher (MHB), solenoids, electrostatic quadrupoles, a velocity equalizer, and a diagnostic system. The ECR ion sources are located on a high-voltage platform to reach an initial beam energy of 10 keV/u. After extraction, the ion beam is transported through the LEBT system to the RFQ accelerator. The generated charge states are selected by an achromatic bending system and then bunched by the MHB in the LEBT system. The MHB is used to achieve a small longitudinal emittance in the RFQ by generating a sawtooth wave with three harmonics. In this paper, we present the results and issues of the beam dynamics of the LEBT system.

  10. SU-E-J-63: Feasibility Study of Proton Digital Tomosynthesis in Proton Beam Therapy.

    Science.gov (United States)

    Min, B; Kwak, J; Lee, J; Cho, S; Park, S; Yoo, S; Chung, K; Cho, S; Lim, Y; Shin, D; Lee, S; Kim, J

    2012-06-01

    We investigated the feasibility of proton tomosynthesis as daily positioning of patients and compared the results with photon tomosynthesis as an alternative to conventional portal imaging or on-board cone-beam computed tomography. Dedicated photon-like proton beam using the passively scattered proton beams by the cyclotron was generated for proton imaging. The eleven projections were acquired over 30 degree with 3 degree increment in order to investigate the performance of proton tomosynthesis. The cylinder blocks and resolution phantom were used to evaluate imaging performance. Resolution phantom of a cylinder of diameter 12 cm was used to investigate the reconstructed imaging characteristics. Electron density cylinder blocks with diameter of 28 mm and height of 70 mm were employed to assess the imaging quality. The solid water, breast, bone, adipose, lung, muscle, and liver, which were tissue equivalent inserts, were positioned around the resolution phantom. The images were reconstructed by projection onto convex sets (POCS) algorithm and total variation minimization (TVM) methods. The Gafchromic EBT films were utilized for measuring the photon-like proton beams as a proton detector. In addition, the photon tomosynthesis images were obtained for a comparison with proton tomosynthesis images. The same angular sampling data were acquired for both proton and photon tomosynthesis. In the resolution phantom image obtained proton tomosynthesis, down to 1.6 mm diameter rods were resolved visually, although the separation between adjacent rods was less distinct. In contrast, down to 1.2 mm diameter rods were resolved visually in the reconstructed image obtained photon tomosynthesis. Both proton and photon tomosynthesis images were similar in intensities of different density blocks. Our results demonstrated that proton tomosynthesis could make it possible to provide comparable tomography imaging to photon tomosynthesis for positioning as determined by manual registration

  11. Clinical proton dosimetry. Part 1: Beam production, beam delivery and measurement of absorbed dose

    International Nuclear Information System (INIS)

    1998-01-01

    The development of accurate and uniform standards for radiation treatment dosimetry has been a continuing effort since the earliest days of radiotherapy. This ICRU Report is intended to promote uniformity of standards that will provide a basis for world-wide comparison of clinical results and allow the development of meaningful clinical trials. This Report describes current practice in proton therapy and recommends standards for the dosimetry of proton treatments. Established proton treatment facilities might use this Report as a source of information for the maintenance of accurate standards. New facilities may build their procedures from recommendations found in this Report and planners of new facilities may examine alternatives within current practice for the production and monitoring of treatment beams. This Report includes a description of the interaction of protons with matter, various methods of beam production, the characteristics of proton beams in clinical use, current methods for beam monitoring and specific recommendations for dose calibration

  12. Prototyping of beam position monitor for medium energy beam transport section of RAON heavy ion accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Hyojae, E-mail: lkcom@ibs.re.kr; Jin, Hyunchang; Jang, Ji-Ho; Hong, In-Seok [Rare Isotope Science Project, Institute for Basic Science, Daejeon (Korea, Republic of)

    2016-02-15

    A heavy ion accelerator, RAON is going to be built by Rare Isotope Science Project in Korea. Its target is to accelerate various stable ions such as uranium, proton, and xenon from electron cyclotron resonance ion source and some rare isotopes from isotope separation on-line. The beam shaping, charge selection, and modulation should be applied to the ions from these ion sources because RAON adopts a superconducting linear accelerator structure for beam acceleration. For such treatment, low energy beam transport, radio frequency quadrupole, and medium energy beam transport (MEBT) will be installed in injector part of RAON accelerator. Recently, development of a prototype of stripline beam position monitor (BPM) to measure the position of ion beams in MEBT section is under way. In this presentation, design of stripline, electromagnetic (EM) simulation results, and RF measurement test results obtained from the prototyped BPM will be described.

  13. Proton beam therapy facility

    International Nuclear Information System (INIS)

    1984-01-01

    It is proposed to build a regional outpatient medical clinic at the Fermi National Accelerator Laboratory (Fermilab), Batavia, Illinois, to exploit the unique therapeutic characteristics of high energy proton beams. The Fermilab location for a proton therapy facility (PTF) is being chosen for reasons ranging from lower total construction and operating costs and the availability of sophisticated technical support to a location with good access to patients from the Chicago area and from the entire nation. 9 refs., 4 figs., 26 tabs

  14. Proton beam therapy facility

    Energy Technology Data Exchange (ETDEWEB)

    1984-10-09

    It is proposed to build a regional outpatient medical clinic at the Fermi National Accelerator Laboratory (Fermilab), Batavia, Illinois, to exploit the unique therapeutic characteristics of high energy proton beams. The Fermilab location for a proton therapy facility (PTF) is being chosen for reasons ranging from lower total construction and operating costs and the availability of sophisticated technical support to a location with good access to patients from the Chicago area and from the entire nation. 9 refs., 4 figs., 26 tabs.

  15. Interaction of Macro-particles with LHC proton beam

    CERN Document Server

    Zimmermann, F; Xagkoni, A

    2010-01-01

    We study the interaction of macro-particles residing inside the LHC vacuum chamber, e.g. soot or thermalinsulation fragments, with the circulating LHC proton beam. The coupled equations governing the motion and charging rate of metallic or dielectric micron-size macroparticles are solved numerically to determine the time spent by such “dust” particles close to the path of the beam as well as the resulting proton-beam losses, which could lead to a quench of superconducting magnets and, thereby, to a premature beam abort.

  16. Exposure parameters in proton beam writing for hydrogen silsesquioxane

    International Nuclear Information System (INIS)

    Kan, J.A. van; Zhang, F.; Zhang, C.; Bettiol, A.A.; Watt, F.

    2008-01-01

    In proton beam writing (PBW) a focused MeV proton beam is scanned in a predetermined pattern over a resist (e.g. PMMA, SU-8 or HSQ), which is subsequently chemically developed. In e-beam writing as well as p-beam writing the energy loss of the primary beam is dominated by energy transfer to substrate electrons. Unlike the high energy secondary electrons generated during e-beam writing the secondary electrons induced by the primary proton beam have low energy and therefore a limited range, resulting in minimal proximity effects. The low proximity effects exhibited by p-beam writing coupled with the straight trajectory and high penetration of the proton beam enables the production of high aspect ratio, high density 3D micro and nanostructures with well defined smooth side walls to be directly written into resist materials. This property together with the stability and focusing power of the end station ensures even exposures with nm smoothness and allows fabrication of details down to the 20 nm level. In this paper, we present results like contrast and sensitivity for PBW using, hydrogen silsesquioxane (HSQ) and XR-1541, both are non-C based resists. Unlike PMMA and SU-8 resist HSQ shows aging effects, requiring optimized processing parameters in PBW

  17. Polarizing a stored proton beam by spin flip?

    International Nuclear Information System (INIS)

    Oellers, D.; Barion, L.; Barsov, S.; Bechstedt, U.; Benati, P.; Bertelli, S.; Chiladze, D.; Ciullo, G.; Contalbrigo, M.; Dalpiaz, P.F.; Dietrich, J.; Dolfus, N.; Dymov, S.; Engels, R.; Erven, W.; Garishvili, A.; Gebel, R.; Goslawski, P.

    2009-01-01

    We discuss polarizing a proton beam in a storage ring, either by selective removal or by spin flip of the stored ions. Prompted by recent, conflicting calculations, we have carried out a measurement of the spin-flip cross section in low-energy electron-proton scattering. The experiment uses the cooling electron beam at COSY as an electron target. The measured cross sections are too small for making spin flip a viable tool in polarizing a stored beam. This invalidates a recent proposal to use co-moving polarized positrons to polarize a stored antiproton beam.

  18. Self-consistent study of space-charge-dominated beams in a misaligned transport system

    International Nuclear Information System (INIS)

    Sing Babu, P.; Goswami, A.; Pandit, V.S.

    2013-01-01

    A self-consistent particle-in-cell (PIC) simulation method is developed to investigate the dynamics of space-charge-dominated beams through a misaligned solenoid based transport system. Evolution of beam centroid, beam envelope and emittance is studied as a function of misalignment parameters for various types of beam distributions. Simulation results performed up to 40 mA of proton beam indicate that centroid oscillations induced by the displacement and rotational misalignments of solenoids do not depend of the beam distribution. It is shown that the beam envelope around the centroid is independent of the centroid motion for small centroid oscillation. In addition, we have estimated the loss of beam during the transport caused by the misalignment for various beam distributions

  19. Production and study of therapeutic proton beams from modernized phasotron at the Laboratory of Nuclear Problems JINR

    International Nuclear Information System (INIS)

    Abazov, V.M.; Gustov, S.A.; Zorin, V.P.; Kutuzov, S.A.; Mirokhin, I.V.; Mitsyn, G.V.; Molokanov, A.G.; Savchenko, O.V.; Filimonov, A.V.

    1986-01-01

    The first results on shaping and transport of therapeutic proton beams of the JINR phasotron are presented. To provide the flat-topped depth-dose distributions with steep back slope, the method of shaping the beam with a necessary energy spectrum from a non-monoenergetic beam is used. Extension of the flat-top of the depth-dose distribution is 4.7 g/cm 2 for the 200 MeV beam energy

  20. Dosimetric assessment of the PRESAGE dosimeter for a proton pencil beam

    International Nuclear Information System (INIS)

    Wuu, C-S; Qian, X; Xu, Y; Adamovics, J; Cascio, E; Lu, H-M

    2013-01-01

    The objective of this study is to assess the feasibility of using PRESAGE dosimeters for proton pencil beam dosimetry. Two different formulations of phantom materials were tested for their suitability in characterizing a single proton pencil beam. The dosimetric response of PRESAGE was found to be linear up to 4Gy. First-generation optical CT scanner, OCTOPUS TM was used to implement dose distributions for proton pencil beams since it provides most accurate readout. Percentage depth dose curves and beam profiles for two proton energy, 110 MeV, and 93 MeV, were used to evaluate the dosimetric performance of two PRESAGE phantom formulas. The findings from this study show that the dosimetric properties of the phantom materials match with basic physics of proton beams.

  1. ALPtraum. ALP production in proton beam dump experiments

    International Nuclear Information System (INIS)

    Doebrich, Babette; Jaeckel, Joerg

    2015-12-01

    With their high beam energy and intensity, existing and near-future proton beam dumps provide an excellent opportunity to search for new very weakly coupled particles in the MeV to GeV mass range. One particularly interesting example is a so-called axion-like particle (ALP), i.e. a pseudoscalar coupled to two photons. The challenge in proton beam dumps is to reliably calculate the production of the new particles from the interactions of two composite objects, the proton and the target atoms. In this work we argue that Primakoff production of ALPs proceeds in a momentum range where production rates and angular distributions can be determined to sufficient precision using simple electromagnetic form factors. Reanalysing past proton beam dump experiments for this production channel, we derive novel constraints on the parameter space for ALPs. We show that the NA62 experiment at CERN could probe unexplored parameter space by running in 'dump mode' for a few days and discuss opportunities for future experiments such as SHiP.

  2. Beam Phase Detection for Proton Therapy Accelerators

    CERN Document Server

    Aminov, Bachtior; Getta, Markus; Kolesov, Sergej; Pupeter, Nico; Stephani, Thomas; Timmer, J

    2005-01-01

    The industrial application of proton cyclotrons for medical applications has become one of the important contributions of accelerator physics during the last years. This paper describes an advanced vector demodulating technique used for non-destructive measurements of beam intensity and beam phase over 360°. A computer controlled I/Q-based phase detector with a very large dynamic range of 70 dB permits the monitoring of beam intensity, phase and eventually energy for wide range of beam currents down to -130 dBm. In order to avoid interference from the fundamental cyclotron frequency the phase detection is performed at the second harmonic frequency. A digital low pass filter with adjustable bandwidth and steepness is implemented to improve accuracy. With a sensitivity of the capacitive pickup in the beam line of 30 nV per nA of proton beam current at 250 MeV, accurate phase and intensity measurements can be performed with beam currents down to 3.3 nA.

  3. WE-D-BRB-02: Proton Treatment Planning and Beam Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Pankuch, M. [Northwestern Medicine Proton Center (United States)

    2016-06-15

    The goal of this session is to review the physics of proton therapy, treatment planning techniques, and the use of volumetric imaging in proton therapy. The course material covers the physics of proton interaction with matter and physical characteristics of clinical proton beams. It will provide information on proton delivery systems and beam delivery techniques for double scattering (DS), uniform scanning (US), and pencil beam scanning (PBS). The session covers the treatment planning strategies used in DS, US, and PBS for various anatomical sites, methods to address uncertainties in proton therapy and uncertainty mitigation to generate robust treatment plans. It introduces the audience to the current status of image guided proton therapy and clinical applications of CBCT for proton therapy. It outlines the importance of volumetric imaging in proton therapy. Learning Objectives: Gain knowledge in proton therapy physics, and treatment planning for proton therapy including intensity modulated proton therapy. The current state of volumetric image guidance equipment in proton therapy. Clinical applications of CBCT and its advantage over orthogonal imaging for proton therapy. B. Teo, B.K Teo had received travel funds from IBA in 2015.

  4. Surface proton transport of fully protonated poly(aspartic acid) thin films on quartz substrates

    Energy Technology Data Exchange (ETDEWEB)

    Nagao, Yuki, E-mail: ynagao@jaist.ac.jp; Kubo, Takahiro

    2014-12-30

    Graphical abstract: - Highlights: • Proton transport of fully protonated poly(aspartic acid) thin film was investigated. • The thin film structure differed greatly from the partially protonated one. • Proton transport occurs on the surface, not inside of the thin film. • This result contributes to biological transport systems such as bacteriorhodopsin. - Abstract: Thin film structure and the proton transport property of fully protonated poly(aspartic acid) (P-Asp100) have been investigated. An earlier study assessed partially protonated poly(aspartic acid), highly oriented thin film structure and enhancement of the internal proton transport. In this study of P-Asp100, IR p-polarized multiple-angle incidence resolution (P-MAIR) spectra were measured to investigate the thin film structure. The obtained thin films, with thicknesses of 120–670 nm, had no oriented structure. Relative humidity dependence of the resistance, proton conductivity, and normalized resistance were examined to ascertain the proton transport property of P-Asp100 thin films. The obtained data showed that the proton transport of P-Asp100 thin films might occur on the surface, not inside of the thin film. This phenomenon might be related with the proton transport of the biological system.

  5. Surface proton transport of fully protonated poly(aspartic acid) thin films on quartz substrates

    International Nuclear Information System (INIS)

    Nagao, Yuki; Kubo, Takahiro

    2014-01-01

    Graphical abstract: - Highlights: • Proton transport of fully protonated poly(aspartic acid) thin film was investigated. • The thin film structure differed greatly from the partially protonated one. • Proton transport occurs on the surface, not inside of the thin film. • This result contributes to biological transport systems such as bacteriorhodopsin. - Abstract: Thin film structure and the proton transport property of fully protonated poly(aspartic acid) (P-Asp100) have been investigated. An earlier study assessed partially protonated poly(aspartic acid), highly oriented thin film structure and enhancement of the internal proton transport. In this study of P-Asp100, IR p-polarized multiple-angle incidence resolution (P-MAIR) spectra were measured to investigate the thin film structure. The obtained thin films, with thicknesses of 120–670 nm, had no oriented structure. Relative humidity dependence of the resistance, proton conductivity, and normalized resistance were examined to ascertain the proton transport property of P-Asp100 thin films. The obtained data showed that the proton transport of P-Asp100 thin films might occur on the surface, not inside of the thin film. This phenomenon might be related with the proton transport of the biological system

  6. Faraday cup dosimetry in a proton therapy beam without collimation

    International Nuclear Information System (INIS)

    Grusell, Erik; Isacsson, Ulf; Montelius, Anders; Medin, Joakim

    1995-01-01

    A Faraday cup in a proton beam can give an accurate measurement of the number of protons collected by the cup. It is shown that the collection efficiency with a proper design can be close to unity. To be able to calibrate an ionization chamber from such a measurement, as is recommended in some dosimetry protocols, the energy spectrum of the proton beam must be accurately known. This is normally not the case when the lateral beam extension is defined by collimators. Therefore a method for relating an ionization chamber measurement in an uncollimated beam to the total number of protons in the beam has been developed and is described together with experimental results from calibrating an ionization chamber using this method in the therapeutic beam in Uppsala. This method is applicable to ionization chambers of any shape and the accuracy is estimated to be 1.6% (1 SD). (Author)

  7. PREFACE: Transport phenomena in proton conducting media Transport phenomena in proton conducting media

    Science.gov (United States)

    Eikerling, Michael

    2011-06-01

    Proton transport phenomena are of paramount importance for acid-base chemistry, energy transduction in biological organisms, corrosion processes, and energy conversion in electrochemical systems such as polymer electrolyte fuel cells. The relevance for such a plethora of materials and systems, and the ever-lasting fascination with the highly concerted nature of underlying processes drive research across disciplines in chemistry, biology, physics and chemical engineering. A proton never travels alone. Proton motion is strongly correlated with its environment, usually comprised of an electrolyte and a solid or soft host material. For the transport in nature's most benign proton solvent and shuttle, water that is, insights from ab initio simulations, matured over the last 15 years, have furnished molecular details of the structural diffusion mechanism of protons. Excess proton movement in water consists of sequences of Eigen-Zundel-Eigen transitions, triggered by hydrogen bond breaking and making in the surrounding water network. Nowadays, there is little debate about the validity of this mechanism in water, which bears a stunning resemblance to the basic mechanistic picture put forward by de Grotthuss in 1806. While strong coupling of an excess proton with degrees of freedom of solvent and host materials facilitates proton motion, this coupling also creates negative synergies. In general, proton mobility in biomaterials and electrochemical proton conducting media is highly sensitive to the abundance and structure of the proton solvent. In polymer electrolyte membranes, in which protons are bound to move in nano-sized water-channels, evaporation of water or local membrane dehydration due to electro-osmotic coupling are well-known phenomena that could dramatically diminish proton conductivity. Contributions in this special issue address various vital aspects of the concerted nature of proton motion and they elucidate important structural and dynamic effects of solvent

  8. Synchrotron accelerator technology for proton beam therapy with high accuracy

    International Nuclear Information System (INIS)

    Hiramoto, Kazuo

    2009-01-01

    Proton beam therapy was applied at the beginning to head and neck cancers, but it is now extended to prostate, lung and liver cancers. Thus the need for a pencil beam scanning method is increasing. With this method radiation dose concentration property of the proton beam will be further intensified. Hitachi group has supplied a pencil beam scanning therapy system as the first one for M. D. Anderson Hospital in United States, and it has been operational since May 2008. Hitachi group has been developing proton therapy system to correspond high-accuracy proton therapy to concentrate the dose in the diseased part which is located with various depths, and which sometimes has complicated shape. The author described here on the synchrotron accelerator technology that is an important element for constituting the proton therapy system. (K.Y.)

  9. Sparse-view proton computed tomography using modulated proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jiseoc; Kim, Changhwan; Cho, Seungryong, E-mail: scho@kaist.ac.kr [Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, Daejon 305-701 (Korea, Republic of); Min, Byungjun [Department of Radiation Oncology, Kangbuk Samsung Hospital, 110–746 (Korea, Republic of); Kwak, Jungwon [Department of Radiation Oncology, Asan Medical Center, 138–736 (Korea, Republic of); Park, Seyjoon; Lee, Se Byeong [Proton Therapy Center, National Cancer Center, 410–769 (Korea, Republic of); Park, Sungyong [Proton Therapy Center, McLaren Cancer Institute, Flint, Michigan 48532 (United States)

    2015-02-15

    Purpose: Proton imaging that uses a modulated proton beam and an intensity detector allows a relatively fast image acquisition compared to the imaging approach based on a trajectory tracking detector. In addition, it requires a relatively simple implementation in a conventional proton therapy equipment. The model of geometric straight ray assumed in conventional computed tomography (CT) image reconstruction is however challenged by multiple-Coulomb scattering and energy straggling in the proton imaging. Radiation dose to the patient is another important issue that has to be taken care of for practical applications. In this work, the authors have investigated iterative image reconstructions after a deconvolution of the sparsely view-sampled data to address these issues in proton CT. Methods: Proton projection images were acquired using the modulated proton beams and the EBT2 film as an intensity detector. Four electron-density cylinders representing normal soft tissues and bone were used as imaged object and scanned at 40 views that are equally separated over 360°. Digitized film images were converted to water-equivalent thickness by use of an empirically derived conversion curve. For improving the image quality, a deconvolution-based image deblurring with an empirically acquired point spread function was employed. They have implemented iterative image reconstruction algorithms such as adaptive steepest descent-projection onto convex sets (ASD-POCS), superiorization method–projection onto convex sets (SM-POCS), superiorization method–expectation maximization (SM-EM), and expectation maximization-total variation minimization (EM-TV). Performance of the four image reconstruction algorithms was analyzed and compared quantitatively via contrast-to-noise ratio (CNR) and root-mean-square-error (RMSE). Results: Objects of higher electron density have been reconstructed more accurately than those of lower density objects. The bone, for example, has been reconstructed

  10. Commissioning of output factors for uniform scanning proton beams

    International Nuclear Information System (INIS)

    Zheng Yuanshui; Ramirez, Eric; Mascia, Anthony; Ding Xiaoning; Okoth, Benny; Zeidan, Omar; Hsi Wen; Harris, Ben; Schreuder, Andries N.; Keole, Sameer

    2011-01-01

    Purpose: Current commercial treatment planning systems are not able to accurately predict output factors and calculate monitor units for proton fields. Patient-specific field output factors are thus determined by either measurements or empirical modeling based on commissioning data. The objective of this study is to commission output factors for uniform scanning beams utilized at the ProCure proton therapy centers. Methods: Using water phantoms and a plane parallel ionization chamber, the authors first measured output factors with a fixed 10 cm diameter aperture as a function of proton range and modulation width for clinically available proton beams with ranges between 4 and 31.5 cm and modulation widths between 2 and 15 cm. The authors then measured the output factor as a function of collimated field size at various calibration depths for proton beams of various ranges and modulation widths. The authors further examined the dependence of the output factor on the scanning area (i.e., uncollimated proton field), snout position, and phantom material. An empirical model was developed to calculate the output factor for patient-specific fields and the model-predicted output factors were compared to measurements. Results: The output factor increased with proton range and field size, and decreased with modulation width. The scanning area and snout position have a small but non-negligible effect on the output factors. The predicted output factors based on the empirical modeling agreed within 2% of measurements for all prostate treatment fields and within 3% for 98.5% of all treatment fields. Conclusions: Comprehensive measurements at a large subset of available beam conditions are needed to commission output factors for proton therapy beams. The empirical modeling agrees well with the measured output factor data. This investigation indicates that it is possible to accurately predict output factors and thus eliminate or reduce time-consuming patient-specific output

  11. Characterization of a proton beam driven by a high-intensity laser

    International Nuclear Information System (INIS)

    Sagisaka, Akito; Daido, Hiroyuki; Ogura, Koichi; Orimo, Satoshi; Hayashi, Yukio; Mori, Michiaki; Nishiuchi, Mamiko; Yogo, Akifumi; Kado, Masataka; Fukumi, Atsushi; Li, Zhong; Pirozhkov, Alexander S.; Nakamura, Shu

    2007-01-01

    High-energy protons are observed with a 3 μm thick tantalum target irradiated with a high intensity laser. The maximum proton energy is ∼900 keV. The half angle of the generated proton beam (>500 keV) is about 10deg. Characterization of the proton beam will significantly contribute to the proton applications. (author)

  12. AA, entrance of proton beam to antiproton production target

    CERN Multimedia

    CERN PhotoLab

    1980-01-01

    Please look up 8010295 first. The intense proton beam from the 26 GeV PS arrives from the right, through the vacuum chamber. The big flange contains a thin window, after which the proton beam continues through free air. A beam transformer, affixed to the shielding block, measures its intensity, before it enters the hole in the concrete to hit the target behind it.

  13. Proton external beam in the TANDAR Accelerator

    International Nuclear Information System (INIS)

    Rey, R.; Schuff, J.A.; Perez de la Hoz, A.; Debray, M.E.; Hojman, D.; Kreiner, A.J.; Kesque, J.M.; Saint-Martin, G.; Oppezzo, O.; Bernaola, O.A.; Molinari, B.L.; Duran, H.A.; Policastro, L.; Palmieri, M.; Ibanez, J.; Stoliar, P.; Mazal, A.; Caraballo, M.E.; Burlon, A.; Cardona, M.A.; Vazquez, M.E.; Salfity, M.F.; Ozafran, M.J.; Naab, F.; Levinton, G.; Davidson, M.; Buhler, M.

    1998-01-01

    An external proton beam has been obtained in the TANDAR accelerator with radiological and biomedical purposes. The protons have excellent physical properties for their use in radiotherapy allowing a very good accuracy in the dose spatial distribution inside the tissue so in the side direction as in depth owing to the presence of Bragg curve. The advantage of the accuracy in the dose localization with proton therapy is good documented (M. Wagner, Med. Phys. 9, 749 (1982); M. Goitein and F. Chen, Med. Phys. 10, 831 (1983); M.R. Raju, Rad. Res. 145, 391 (1996)). It was obtained external proton beams with energies between 15-25 MeV, currents between 2-10 p A and a uniform transversal sections of 40 mm 2 approximately. It was realized dosimetric evaluations with CR39 and Makrofol foliation. The irradiations over biological material contained experiences In vivo with laboratory animals, cellular and bacterial crops. It was fixed the optimal conditions of position and immobilization of the Wistar rats breeding for the In vivo studies. It was chosen dilutions and sowing techniques adequate for the exposition at the cellular and bacterial crops beam. (Author)

  14. Distribution uniformity of laser-accelerated proton beams

    Science.gov (United States)

    Zhu, Jun-Gao; Zhu, Kun; Tao, Li; Xu, Xiao-Han; Lin, Chen; Ma, Wen-Jun; Lu, Hai-Yang; Zhao, Yan-Ying; Lu, Yuan-Rong; Chen, Jia-Er; Yan, Xue-Qing

    2017-09-01

    Compared with conventional accelerators, laser plasma accelerators can generate high energy ions at a greatly reduced scale, due to their TV/m acceleration gradient. A compact laser plasma accelerator (CLAPA) has been built at the Institute of Heavy Ion Physics at Peking University. It will be used for applied research like biological irradiation, astrophysics simulations, etc. A beamline system with multiple quadrupoles and an analyzing magnet for laser-accelerated ions is proposed here. Since laser-accelerated ion beams have broad energy spectra and large angular divergence, the parameters (beam waist position in the Y direction, beam line layout, drift distance, magnet angles etc.) of the beamline system are carefully designed and optimised to obtain a radially symmetric proton distribution at the irradiation platform. Requirements of energy selection and differences in focusing or defocusing in application systems greatly influence the evolution of proton distributions. With optimal parameters, radially symmetric proton distributions can be achieved and protons with different energy spread within ±5% have similar transverse areas at the experiment target. Supported by National Natural Science Foundation of China (11575011, 61631001) and National Grand Instrument Project (2012YQ030142)

  15. Proton therapy

    International Nuclear Information System (INIS)

    Jongen, Y.

    1995-01-01

    Ideal radiotherapy deposits a large amount of energy in the tumour volume, and none in the surrounding healthy tissues. Proton therapy comes closer to this goal because of a greater concentration of dose, well defined proton ranges and points of energy release which are precisely known - the Bragg peak1. In the past, the development of clinical proton therapy has been hampered by complexity, size, and cost. To be clinically effective, energies of several hundred MeV are required; these were previously unavailable for hospital installations, and pioneering institutions had to work with complex, inadequate equipment originally intended for nuclear physics research. Recently a number of specialist organizations and commercial companies have been working on dedicated systems for proton therapy. One, IBA of Belgium, has equipment for inhouse hospital operation which encompasses a complete therapy centre, delivered as a turnkey package and incorporating a compact, automated, higher energy cyclotron with isocentric gantries. Their system will be installed at Massachusetts General Hospital, Boston. The proton therapy system comprises: - a 235 MeV isochronous cyclotron to deliver beams of up to 1.5 microamps, but with a hardware limitation to restrict the maximum possible dose; - variable energy beam (235 to 70 MeV ) with energy spread and emittance verification; - a beam transport and switching system to connect the exit of the energy selection system to the entrances of a number of gantries and fixed beamlines. Along the beam transport system, the beam characteristics are monitored with non-interceptive multiwire ionization chambers for automatic tuning; - gantries fitted with nozzles and beamline elements for beam control; both beam scattering and beam wobbling techniques are available for shaping the beam;

  16. Srna - Monte Carlo codes for proton transport simulation in combined and voxelized geometries

    Directory of Open Access Journals (Sweden)

    Ilić Radovan D.

    2002-01-01

    Full Text Available This paper describes new Monte Carlo codes for proton transport simulations in complex geometrical forms and in materials of different composition. The SRNA codes were developed for three dimensional (3D dose distribution calculation in proton therapy and dosimetry. The model of these codes is based on the theory of proton multiple scattering and a simple model of compound nucleus decay. The developed package consists of two codes: SRNA-2KG and SRNA-VOX. The first code simulates proton transport in combined geometry that can be described by planes and second order surfaces. The second one uses the voxelized geometry of material zones and is specifically adopted for the application of patient computer tomography data. Transition probabilities for both codes are given by the SRNADAT program. In this paper, we will present the models and algorithms of our programs, as well as the results of the numerical experiments we have carried out applying them, along with the results of proton transport simulation obtained through the PETRA and GEANT programs. The simulation of the proton beam characterization by means of the Multi-Layer Faraday Cup and spatial distribution of positron emitters obtained by our program indicate the imminent application of Monte Carlo techniques in clinical practice.

  17. Induction of cancer cell death by proton beam in tumor hypoxic region

    International Nuclear Information System (INIS)

    Lee, Y. M.; Heo, T. R.; Lee, K. B.; Jang, K. H.; Kim, H. N.; Lee, S. H.; Jeong, M. H.

    2008-04-01

    Proton beam has been applied to treat various tumor patients in clinical studies. However, it is still undefined whether proton radiation can inhibit the blood vessel formation and induce the cell death in vascular endothelial cells in growing organs. The aim of this study are first, to develop an optimal animal model for the observation of blood vessel development with low dose of proton beam and second, to investigate the effect of low dose proton beam on the inhibition of blood vessel formation induced by hypoxic conditions. In this study, flk1-GFP transgenic zebrafish embryos were used to directly visualize and determine the inhibition of blood vessels by low dose (1, 2, 5 Gy) of proton beam with spread out Bragg peak (SOBP). And we observed cell death by acridine orange staining at 96 hours post fertilization (hpf) stage of embryos after proton irradiation. We also compared the effects of proton beam with those of gamma-ray. An antioxidant, N-acetyl cystein (NAC) was used to investigate whether reactive oxygen species (ROS) were involved in the cell deaths induced by proton irradiation. Irradiated flk-1-GFP transgenic embryos with proton beam irradiation (35 MeV, spread out Bragg peak, SOBP) demonstrated a marked inhibition of embryonic growth and an altered fluorescent blood vessel development in the trunk region. When the cells with DNA damage in the irradiated zebrafish were stained with acridine orange, green fluorescent cell death spots were increased in trunk regions compared to non-irradiated control embryos. Proton beam also significantly increased the cell death rate in human umbilical vein endothelial cells (HUVEC), but pretreatment of N-acetyl cystein (NAC), an antioxidant, recovered the proton-induced cell death rate (p<0.01). Moreover, pretreatment of NAC abrogated the effect of proton beam on the inhibition of trunk vessel development and malformation of trunk truncation. From this study, we found that proton radiation therapy can inhibit the

  18. Dosimetry of clinical neutron and proton beams: An overview of recommendations

    International Nuclear Information System (INIS)

    Vynckier, S.

    2004-01-01

    Neutron therapy beams are obtained by accelerating protons or deuterons on Beryllium. These neutron therapy beams present comparable dosimetric characteristics as those for photon beams obtained with linear accelerators; for instance, the penetration of a p(65) + Be neutron beam is comparable with the penetration of an 8 MV photon beam. In order to be competitive with conventional photon beam therapy, the dosimetric characteristics of the neutron beam should therefore not deviate too much from the photon beam characteristics. This paper presents a brief summary of the neutron beams used in radiotherapy. The dosimetry of the clinical neutron beams is described. Finally, recent and future developments in the field of physics for neutron therapy is mentioned. In the last two decades, a considerable number of centres have established radiotherapy treatment facilities using proton beams with energies between 50 and 250 MeV. Clinical applications require a relatively uniform dose to be delivered to the volume to be treated, and for this purpose the proton beam has to be spread out, both laterally and in depth. The technique is called 'beam modulation' and creates a region of high dose uniformity referred to as the 'spread-out Bragg peak'. Meanwhile, reference dosimetry in these beams had to catch up with photon and electron beams for which a much longer tradition of dosimetry exists. Proton beam dosimetry can be performed using different types of dosemeters, such as calorimeters, Faraday cups, track detectors and ionisation chambers. National standard dosimetry laboratories will, however, not provide a standard for the dosimetry of proton beams. To achieve uniformity on an international level, the use of an ionisation chamber should be considered. This paper reviews and summarises the basic principles and recommendations for the absorbed dose determination in a proton beam, utilising ionisation chambers calibrated in terms of absorbed dose to water. These recommendations

  19. Therapeutic study of proton beam in vascular disease animal models

    International Nuclear Information System (INIS)

    Lee, Y. M.; Jang, K. H.; Kim, M. J.; Choi, J. H.

    2010-04-01

    We previously reported that proton beam inhibited angiogenic vessels in zebrafish and that proton induced cancer cell apoptosis via p53 induction as well as caspase-3 activity. In this study, we performed to identity the effect of candidate chemicals on the angiogenic inhibition in vitro and in vivo (zebrafish Flk1:EGFP transgenic fish). And we treated small cell lung adenocarcinoma cell line, A549 cells with proton beam in combination with angiogenic inhibitors we found in this study. By the MTT assay, we performed cell viability assay with cancer cells and we investigated that HIF-1α induction by proton beam by the western blot analysis. We found novel anti-angiogenic chemicals from traditional herb. That is decursin, and glyceollins from the Angelica gigas, and soy bean. Decrusin and glyceollins inhibited VEGF- or bFGF-induced endothelial cell proliferation, migration and zebrafish microvessel development. Moreover, glyceollins inhibited hypoxia-induced HIF-1α in a dose dependent manner. However, proton beam itself did not induce HIF-1α whereas it increased HIF-1α stability under hypoxia. Even proton beam induced cell death of A549 small cell lung carcinoma cells but the combination of decrusin or glyceollins did not increase the cancer cell death

  20. Therapeutic study of proton beam in vascular disease animal models

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Y. M.; Jang, K. H.; Kim, M. J.; Choi, J. H. [Kyungpook National University, Daegu (Korea, Republic of)

    2010-04-15

    We previously reported that proton beam inhibited angiogenic vessels in zebrafish and that proton induced cancer cell apoptosis via p53 induction as well as caspase-3 activity. In this study, we performed to identity the effect of candidate chemicals on the angiogenic inhibition in vitro and in vivo (zebrafish Flk1:EGFP transgenic fish). And we treated small cell lung adenocarcinoma cell line, A549 cells with proton beam in combination with angiogenic inhibitors we found in this study. By the MTT assay, we performed cell viability assay with cancer cells and we investigated that HIF-1{alpha} induction by proton beam by the western blot analysis. We found novel anti-angiogenic chemicals from traditional herb. That is decursin, and glyceollins from the Angelica gigas, and soy bean. Decrusin and glyceollins inhibited VEGF- or bFGF-induced endothelial cell proliferation, migration and zebrafish microvessel development. Moreover, glyceollins inhibited hypoxia-induced HIF-1{alpha} in a dose dependent manner. However, proton beam itself did not induce HIF-1{alpha} whereas it increased HIF-1{alpha} stability under hypoxia. Even proton beam induced cell death of A549 small cell lung carcinoma cells but the combination of decrusin or glyceollins did not increase the cancer cell death

  1. Numerical simulations of self-pinched transport of intense ion beams in low-pressure gases

    International Nuclear Information System (INIS)

    Rose, D.V.; Ottinger, P.F.; Welch, D.R.; Oliver, B.V.; Olson, C.L.

    1999-01-01

    The self-pinched transport of intense ion beams in low-pressure background gases is studied using numerical simulations and theoretical analysis. The simulations are carried out in a parameter regime that is similar to proton beam experiments being fielded on the Gamble II pulsed power generator [J. D. Shipman, Jr., IEEE Trans. Nucl. Sci. NS-18, 243 (1971)] at the Naval Research Laboratory. Simulation parameter variations provide information on scaling with background gas species, gas pressure, beam current, beam energy, injection angles, and boundaries. The simulation results compare well with simple analytic scaling arguments for the gas pressure at which the effective net current should peak and with estimates for the required confinement current. The analysis indicates that the self-pinched transport of intense proton beams produced on Gamble II (1.5 MeV, 100 kA, 3 cm radius) is expected to occur at gas pressures between 30 and 80 mTorr of He or between 3 and 10 mTorr of Ar. The significance of these results to ion-driven inertial confinement fusion is discussed. copyright 1999 American Institute of Physics

  2. Current neutralization in ballistic transport of light ion beams

    International Nuclear Information System (INIS)

    Hubbard, R.F.; Slinker, S.P.; Lampe, M.; Joyce, G.; Ottinger, P.

    1992-01-01

    Intense light ion beams are being considered as drivers to ignite fusion targets in the Laboratory Microfusion Facility (LMF). Ballistic transport of these beams from the diode to the target is possible only if the beam current is almost completely neutralized by plasma currents. This paper summarizes related work on relativistic electron beam and heavy ion beam propagation and describes a simple simulation model (DYNAPROP) which has been modified to treat light ion beam propagation. DYNAPROP uses an envelope equation to treat beam dynamics and uses rate equations to describe plasma and conductivity generation. The model has been applied both to the high current, 30 MeV Li +3 beams for LMF as well as low current, 1.2 MeV proton beams which are currently being studied on GAMBLE B at the Naval Research Laboratory. The predicted ratio of net currents to beam current is ∼0.1--0.2 for the GAMBLE experiment and ∼0.01 for LMF. The implications of these results for LMF and the GAMBLE experiments art discussed in some detail. The simple resistive model in DYNAPROP has well-known limitations in the 1 torr regime which arise primarily from the neglect of plasma electron transport. Alternative methods for treating the plasma response are discussed

  3. Influence of transverse diffusion within the proton beam fast-ignitor scenario

    International Nuclear Information System (INIS)

    Barriga-Carrasco, Manuel D.; Maynard, Gilles; Kurilenkov, Yuri K.

    2004-01-01

    Fast ignition of an inertial confinement fusion target by an energetic proton beam is here re-examined. We put special emphasis on the role of the transverse dispersion of the beam induced during its travel between the proton source and the compressed deuterium-tritium (DT) fuel. The theoretical model and the computer code used in our calculations are presented. Different beam initial energy distributions are analyzed. We found that the beam exhibits small collective effects while multiple scattering collisions provide a substantial transverse dispersion of the beam. Therefore, the nuclear dispersion imposes severe restrictions on the schemes for fast ignitor even considering an ideal monoenergetic and noncorrelated proton beam

  4. An analysis of beam parameters on proton-acoustic waves through an analytic approach.

    Science.gov (United States)

    Kipergil, Esra Aytac; Erkol, Hakan; Kaya, Serhat; Gulsen, Gultekin; Unlu, Mehmet Burcin

    2017-06-21

    It has been reported that acoustic waves are generated when a high-energy pulsed proton beam is deposited in a small volume within tissue. One possible application of proton-induced acoustics is to get real-time feedback for intra-treatment adjustments by monitoring such acoustic waves. A high spatial resolution in ultrasound imaging may reduce proton range uncertainty. Thus, it is crucial to understand the dependence of the acoustic waves on the proton beam characteristics. In this manuscript, firstly, an analytic solution for the proton-induced acoustic wave is presented to reveal the dependence of the signal on the beam parameters; then it is combined with an analytic approximation of the Bragg curve. The influence of the beam energy, pulse duration and beam diameter variation on the acoustic waveform are investigated. Further analysis is performed regarding the Fourier decomposition of the proton-acoustic signals. Our results show that the smaller spill time of the proton beam upsurges the amplitude of the acoustic wave for a constant number of protons, which is hence beneficial for dose monitoring. The increase in the energy of each individual proton in the beam leads to the spatial broadening of the Bragg curve, which also yields acoustic waves of greater amplitude. The pulse duration and the beam width of the proton beam do not affect the central frequency of the acoustic wave, but they change the amplitude of the spectral components.

  5. IPROP simulations of the GAMBLE II proton transport experiment

    International Nuclear Information System (INIS)

    Welch, D.R.

    1993-01-01

    The author has simulated the proton transport of the 6-kA, 1-MV GAMBLE II experiment using a modified version of the IPROP particle-in-cell code. IPROP now uses a hybrid model in which plasma electrons are divided into high-energy macro particle and thermal-fluid components. This model includes open-quotes knock-onclose quotes bound-electron collision and runaway sources for high-energy electrons. Using IPROP, the authors has calculated net currents in reasonable agreement with the experiment ranging from 5-11% of the total current in pressures from 0.25-4 torr helium. In the simulations, the pinch current sample by the 1.5-cm beam was 2-3 times larger than the net current at 4 cm radius. The attenuation of net current at larger radii was the result of a highly-conductive energetic component of plasma electrons surrounding the beam. Having benchmarked IPROP against experiment, the author has examined higher-current ion beams with respect to possible transport for inertial confinement fusion

  6. Slaw extracted proton beam formation and monitoring for the ''QUARTZ'' setup

    International Nuclear Information System (INIS)

    Bushnin, Yu.B.; Gres', V.N.; Davydenko, Yu.P.

    1982-01-01

    The version of optical mode of the beam channel providing with simultaneous operating the experimental setups FODS and ''QUARTZ'' at consecutive usage of the slow extracted proton beam is reported. The ''QUARTZ'' setup beam diagnostics system comprises two subsystems: for measuring beam profile beam timing structure and beam intensity and operates in the beam extraction duration from 20 ns to few seconds at beam intensity from 10 10 to 5x10 12 protons/pulse. The ''QUARTZ'' setup represents a focusing crystal-diffraction spectrometer with 5-meter focal distance and Ge(Li) special construction detector. High efficiency target is applied in the setup. The ''QUARTZ'' setup is designed for studying exotic atoms produced by negative charged heavy particles (π, K, μ, P tilde) and atomic nuclei. Precise energy measurement of X ray transitions in such atoms is performed. For measuring beam geometric parameters 32-channel secondary emission chambers are used. As detector of beam intensity and timing structure of slow extracted beam the secondary emission chamber is employed. The principle circuit of current integrator is given. As data transmission line a 50-pair telephone cable is used. Information conversion into digital form and its subsequent processing is performed in the CAMAC system and the SM-3 computer. The proton beam full intensity measuring system provides with accuracy not worse than +-4.5% in the 10 10 -10 12 proton/sec range. The implemented optical mode of the beam channel and proton beam monitoring system permitted to begin fulfillment of the experimental program on the ''QUARTZ'' setup

  7. Effect of Proton Beam on Cancer Progressive and Metastatic Enzymes

    International Nuclear Information System (INIS)

    Sohn, Y. H.; Nam, K. S.; Oh, Y. H.; Kim, M. K.; Kim, M. Y.; Jang, J. S.

    2008-04-01

    The purpose of this study was to investigate the effect of proton beam on enzymes for promotion/progression of carcinogenesis and metastasis of malignant tumor cells to clarify proton beam-specific biological effects. The changes of cancer chemopreventive enzymes in human colorectal adenocarcinoma HT-29 cells irradiated with proton beams were tested by measuring the activities of quinine reductase (QR), glutathione S-transferase (GST), and ornithine decarboxylase (ODC), glutathione (GSH) levels, and expression of cyclooxygenase-2 (COX-2). We also examined the effect of proton beam on the ODC activity and expression of COX-2 in human breast cancer cell. We then assessed the metastatic capabilities of HT-29 and MDA-MB-231 cells irradiated with proton beam by measuring the invasiveness of cells through Matrigel-coated membrane and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP activity in MDA-MB-231 and HT-29 cells. QR activity of irradiated HT-29 cells was slightly increased. Proton irradiation at dose of 32 Gy in HT-29 cells increased GST activity by 1.23-fold. In addition GSH levels in HT-29 cells was significantly increased 1.23- (p<0.05), 1.32- (p<0.01) and 1.34-fold (p<0.01) with the proton irradiation at doses of 8, 16 and 32 Gy, respectively. These results suggest that colon cancer chemopreventive activity was increased with the proton irradiation by increasing QR and GST activities and GSH levels and inhibiting ODC activity. Proton ion irradiation decreased the invasiveness of TPA-treated HT-29 cells and MDA-MB-231 cells through Matrigel-coated membrane. Proton ion irradiation pretreatment decreased TPA-induced MMP activity in MDA-MB-231 and HT-29 cells. Further studies are necessary to investigate if these findings could be translated to in vivo situations

  8. Biological effects and application of proton beam (H+) implantation on melon seeds

    International Nuclear Information System (INIS)

    Sun Xun; Ren Ruixing; Meng Hui; Shi Jinguo; Tang Zhangxiong; Tao Xianping

    2006-01-01

    Various doses and energy of the proton beam (H + ) were used to treat dry seeds of melon (Cucumis melo L.). Results show that, the proton beam irradiation can induced structural variations of chromosomes and abnormal behaviors during mitosis and meiosis. The percentage of cells with chromosomal aberration increased with the increment of energy and dose of the proton. The micronuclei, chromosomal bridge and chromosomal fragments were included in chromosomal aberration. The proton beam was effective in inducing mutants of early maturity. A early maturity line T 63-1-17-8-1-3 was selected from the progenies of the seeds treated with the proton beam. (authors)

  9. Modification of semiconductors with proton beams. A review

    International Nuclear Information System (INIS)

    Kozlovskii, V.V.; Lomasov, V.N.; Kozlov, V.A.

    2000-01-01

    Analysis is given of the progress in the modification of semiconductors by proton beams in fields such as proton-enhanced diffusion, ion-beam mixing, and formation of porous layers. This method of modification (doping) is shown to have high potential in monitoring the properties of semiconductor materials and designing devices of micro and nano electronics as compared to the conventional doping techniques such as thermal diffusion, epitaxy, and ion implantation

  10. Surface proton transport of fully protonated poly(aspartic acid) thin films on quartz substrates

    Science.gov (United States)

    Nagao, Yuki; Kubo, Takahiro

    2014-12-01

    Thin film structure and the proton transport property of fully protonated poly(aspartic acid) (P-Asp100) have been investigated. An earlier study assessed partially protonated poly(aspartic acid), highly oriented thin film structure and enhancement of the internal proton transport. In this study of P-Asp100, IR p-polarized multiple-angle incidence resolution (P-MAIR) spectra were measured to investigate the thin film structure. The obtained thin films, with thicknesses of 120-670 nm, had no oriented structure. Relative humidity dependence of the resistance, proton conductivity, and normalized resistance were examined to ascertain the proton transport property of P-Asp100 thin films. The obtained data showed that the proton transport of P-Asp100 thin films might occur on the surface, not inside of the thin film. This phenomenon might be related with the proton transport of the biological system.

  11. Direct-current proton-beam measurements at Los Alamos

    International Nuclear Information System (INIS)

    Sherman, J.; Stevens, R.R.; Schneider, J.D.; Zaugg, T.

    1994-01-01

    Recently, a CW proton accelerator complex was moved from Chalk River Laboratories (CRL) to Los Alamos National Laboratory. This includes a 50-keV dc proton injector with a single-solenoid low-energy beam transport system (LEBT) and a CW 1.25-MeV, 267-MHz radiofrequency quadrupole (RFQ). The move was completed after CRL had achieved 55-mA CW operation at 1.25 MeV using 250-kW klystrode tubes to power the RFQ. These accelerator components are prototypes for the front end of a CW linac required for an accelerator-driven transmutation linac, and they provide early confirmation of some CW accelerator components. The injector (ion source and LEBT) and emittance measuring unit are installed and operational at Los Alamos. The dc microwave ion source has been operated routinely at 50-keV, 75-mA hydrogen-ion current. This ion source has demonstrated very good discharge and H 2 gas efficiencies, and sufficient reliability to complete CW RFQ measurements at CRL. Proton fraction of 75% has been measured with 550-W discharge power. This high proton fraction removes the need for an analyzing magnet. Proton LEBT emittance measurements completed at Los Alamos suggest that improved transmission through the RFQ may be achieved by increasing the solenoid focusing current. Status of the final CW RFQ operation at CRL and the installation of the RFQ at Los Alamos is given

  12. A light-weight compact proton gantry design with a novel dose delivery system for broad-energetic laser-accelerated beams.

    Science.gov (United States)

    Masood, U; Cowan, T E; Enghardt, W; Hofmann, K M; Karsch, L; Kroll, F; Schramm, U; Wilkens, J J; Pawelke, J

    2017-07-07

    Proton beams may provide superior dose-conformity in radiation therapy. However, the large sizes and costs limit the widespread use of proton therapy (PT). The recent progress in proton acceleration via high-power laser systems has made it a compelling alternative to conventional accelerators, as it could potentially reduce the overall size and cost of the PT facilities. However, the laser-accelerated beams exhibit different characteristics than conventionally accelerated beams, i.e. very intense proton bunches with large divergences and broad-energy spectra. For the application of laser-driven beams in PT, new solutions for beam transport, such as beam capture, integrated energy selection, beam shaping and delivery systems are required due to the specific beam parameters. The generation of these beams are limited by the low repetition rate of high-power lasers and this limitation would require alternative solutions for tumour irradiation which can efficiently utilize the available high proton fluence and broad-energy spectra per proton bunch to keep treatment times short. This demands new dose delivery system and irradiation field formation schemes. In this paper, we present a multi-functional light-weight and compact proton gantry design for laser-driven sources based on iron-less pulsed high-field magnets. This achromatic design includes improved beam capturing and energy selection systems, with a novel beam shaping and dose delivery system, so-called ELPIS. ELPIS system utilizes magnetic fields, instead of physical scatterers, for broadening the spot-size of broad-energetic beams while capable of simultaneously scanning them in lateral directions. To investigate the clinical feasibility of this gantry design, we conducted a treatment planning study with a 3D treatment planning system augmented for the pulsed beams with optimizable broad-energetic widths and selectable beam spot sizes. High quality treatment plans could be achieved with such unconventional beam

  13. A light-weight compact proton gantry design with a novel dose delivery system for broad-energetic laser-accelerated beams

    Science.gov (United States)

    Masood, U.; Cowan, T. E.; Enghardt, W.; Hofmann, K. M.; Karsch, L.; Kroll, F.; Schramm, U.; Wilkens, J. J.; Pawelke, J.

    2017-07-01

    Proton beams may provide superior dose-conformity in radiation therapy. However, the large sizes and costs limit the widespread use of proton therapy (PT). The recent progress in proton acceleration via high-power laser systems has made it a compelling alternative to conventional accelerators, as it could potentially reduce the overall size and cost of the PT facilities. However, the laser-accelerated beams exhibit different characteristics than conventionally accelerated beams, i.e. very intense proton bunches with large divergences and broad-energy spectra. For the application of laser-driven beams in PT, new solutions for beam transport, such as beam capture, integrated energy selection, beam shaping and delivery systems are required due to the specific beam parameters. The generation of these beams are limited by the low repetition rate of high-power lasers and this limitation would require alternative solutions for tumour irradiation which can efficiently utilize the available high proton fluence and broad-energy spectra per proton bunch to keep treatment times short. This demands new dose delivery system and irradiation field formation schemes. In this paper, we present a multi-functional light-weight and compact proton gantry design for laser-driven sources based on iron-less pulsed high-field magnets. This achromatic design includes improved beam capturing and energy selection systems, with a novel beam shaping and dose delivery system, so-called ELPIS. ELPIS system utilizes magnetic fields, instead of physical scatterers, for broadening the spot-size of broad-energetic beams while capable of simultaneously scanning them in lateral directions. To investigate the clinical feasibility of this gantry design, we conducted a treatment planning study with a 3D treatment planning system augmented for the pulsed beams with optimizable broad-energetic widths and selectable beam spot sizes. High quality treatment plans could be achieved with such unconventional beam

  14. The polarized proton and deuteron beam at the Bonn isochronous cyclotron

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, K G; Enders, R; Hammon, W; Krause, K D; Lesemann, D; Scholzen, A [Bonn Univ. (F.R. Germany). Inst. fuer Angewandte Physik; Euler, K; Schueller, B [Bonn Univ. (F.R. Germany). Inst. fuer Strahlen- und Kernphysik

    1976-02-15

    The present state of the polarized proton and deuteron source at the Bonn cyclotron is described. The source, which is of the atomic beam type, gives typical ion beam intensities of 2 ..mu..A for protons and 3 ..mu..A for deuterons. The overall transmission from the source to the first stopper after extraction from the cyclotron is 3%. Target currents with an energy resolution E/..delta..E=500 are 20 nA for deuterons and 10 nA for protons. For the proton beam, a polarization P=-0.71 was measured. For the deuteron beam, a pure vector polarization Psub(z)=-0.47 or various mixtures of vector and tensor polarization are obtained.

  15. Laser-driven proton beams applied to radiobiological experiments

    International Nuclear Information System (INIS)

    Yogo, Akifumi

    2012-01-01

    The proton accelerators based on the high intensity laser system generate shorter and higher pulse beams compared to the conventional particle accelerators used for the cancer therapy. To demonstrate the radiobiological effects of the new proton beams, the program to develop a biological irradiation instrument for the DNA double-strand break was started in the fiscal year 2008. A prototype instrument was made by making use of the J-KAREN (JAEA Kansai Advanced Relativistic Engineering) laser beam. Polyimide thin film targets were used to irradiate A-549 cells. The DNA double-strand break was tested by the fluorescence spectrometry. In the second year the quantitative yield of the DNA double-strand break and its proton dose dependence were measured. The results indicated that they were comparative to the cases of the conventional particle accelerators. In the fiscal year of 2010 the design of the magnetic field for the energy selection has been changed. The new irradiation instrument, the main part of which is only about 40 cm in length as illustrated in the figure, has been constructed and tested. The experiment has been carried out using the human cancer cells (HSG) and the relative biological effectiveness (RBE) has been quantitatively evaluated by the colony assay for varied distribution of the proton beam energy. The survival fractions plotted against the dose were in good agreement with the case of 3 He beam. RBE was found not to be changed up to 1x10 7 Gy/s. Stability of the energy peak, half width and the proton density has been confirmed for this very compact instrument. (S. Funahashi)

  16. Beam diagnostics for Laser-induced proton generation at KAERI

    International Nuclear Information System (INIS)

    Kim, Dong Heun; Park, Seong Hee; Jeong, Young Uk; Lee, Ki Tae; Chan, Young Ho; Lee, Byung Cheol; Yoo, Byeong Duk

    2005-01-01

    With an advent of femto-second lasers, a laseraccelerated ion generation has been world-widely studied for medical and nuclear applications. It is known that protons with the energy from several tens MeV to a few hundreds MeV require for a cancer therapy and nuclear reaction. Even though, up to present, the maximum energy of laser-accelerated proton is about 60 MeV, it is expected that the energy of protons generated can be obtained at least up to 150 MeV. According to theoretical and experimental works, it turns out the energy distribution and the flux of ions strongly depends on the intensity of a fs laser at a target. However, physics on laser-plasma interaction is still not clear. The precise measurements of parameters of a fs laser and ions are important to figure out the physics and develop the theoretical interpretation. Typically, beam diagnostic system includes measurements and/or monitoring of the temporal and spatial profiles of lasers at the target as well as the energy spectrum and density profile of protons, which are critical for the analysis of mechanism and the characterization of protons generated. We fabricated and installed the target chamber for laser-accelerated proton generation and are now integrating beam diagnostic system. For laser diagnostics, beam monitoring and alignment system has been installed. For a charged particle, CR-39 detectors, Thomson parabola spectrometer, and Si charged particle detectors are installed for density profile and energy spectrum. In this paper, we discuss the laser beam monitoring and alignment system. We also estimates expected spectrum of protons from Thomson parabola spectrometer, depending on the parameters of protons

  17. Pitfalls of tungsten multileaf collimator in proton beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Moskvin, Vadim; Cheng, Chee-Wai; Das, Indra J. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202 (United States) and Indiana University Health Proton Therapy Center (Formerly Midwest Proton Radiotherapy Institute), Bloomington, Indiana 47408 (United States)

    2011-12-15

    Purpose: Particle beam therapy is associated with significant startup and operational cost. Multileaf collimator (MLC) provides an attractive option to improve the efficiency and reduce the treatment cost. A direct transfer of the MLC technology from external beam radiation therapy is intuitively straightforward to proton therapy. However, activation, neutron production, and the associated secondary cancer risk in proton beam should be an important consideration which is evaluated. Methods: Monte Carlo simulation with FLUKA particle transport code was applied in this study for a number of treatment models. The authors have performed a detailed study of the neutron generation, ambient dose equivalent [H*(10)], and activation of a typical tungsten MLC and compared with those obtained from a brass aperture used in a typical proton therapy system. Brass aperture and tungsten MLC were modeled by absorber blocks in this study, representing worst-case scenario of a fully closed collimator. Results: With a tungsten MLC, the secondary neutron dose to the patient is at least 1.5 times higher than that from a brass aperture. The H*(10) from a tungsten MLC at 10 cm downstream is about 22.3 mSv/Gy delivered to water phantom by noncollimated 200 MeV beam of 20 cm diameter compared to 14 mSv/Gy for the brass aperture. For a 30-fraction treatment course, the activity per unit volume in brass aperture reaches 5.3 x 10{sup 4} Bq cm{sup -3} at the end of the last treatment. The activity in brass decreases by a factor of 380 after 24 h, additional 6.2 times after 40 days of cooling, and is reduced to background level after 1 yr. Initial activity in tungsten after 30 days of treating 30 patients per day is about 3.4 times higher than in brass that decreases only by a factor of 2 after 40 days and accumulates to 1.2 x 10{sup 6} Bq cm{sup -3} after a full year of operation. The daily utilization of the MLC leads to buildup of activity with time. The overall activity continues to increase

  18. Fabrication of Multi-Harmonic Buncher for Pulsed Proton Beam Generation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, H. S.; Kwon, H. J.; Cho, Y. S. [Korea Multipurpose Accelerator Complex, Gyeongju (Korea, Republic of)

    2015-05-15

    Fast neutrons with a broad spectrum can be generated by irradiating the proton beams on target materials. To measure the neutron energy by time of flight (TOF) method, the short pulse width of the proton beam is preferred because the neutron energy uncertainty is proportional to the pulse width. In addition, the pulse repetition rate should be low enough to extend the lower limit of the available neutron energy. Pulsed proton beam generation system is designed based on an electrostatic deflector and slit system as shown in Fig. 1. In a simple deflector with slit system, most of the proton beam is blocked by slit, especially when the beam pulse width is short. The ideal field pattern inside the buncher cavity is saw-tooth wave. To make the field pattern similar to the saw-tooth waveform, we adopted a multi-harmonic buncher (MHB). The design for the multi-harmonic buncher including 3D electromagnetic calculation has been performed. Based on the design, a multi-harmonic buncher cavity was fabricated. It consists of two resonators, two drift tubes and a vacuum chamber. The resonator is a quarter-wave coaxial resonator type. The drift tube is connected to the resonator by using a coaxial vacuum feedthrough. Design summary and detailed fabrication method of the multi-harmonic buncher is presented in this paper. A multi-harmonic buncher for a proton beam chopper system to generate a short pulse neutron beam was designed, fabricated and assembled.

  19. Proton beam radiotherapy of iris melanoma

    International Nuclear Information System (INIS)

    Damato, Bertil; Kacperek, Andrzej; Chopra, Mona; Sheen, Martin A.; Campbell, Ian R.; Errington, R. Douglas

    2005-01-01

    Purpose: To report on outcomes after proton beam radiotherapy of iris melanoma. Methods and Materials: Between 1993 and 2004, 88 patients with iris melanoma received proton beam radiotherapy, with 53.1 Gy in 4 fractions. Results: The patients had a mean age of 52 years and a median follow-up of 2.7 years. The tumors had a median diameter of 4.3 mm, involving more than 2 clock hours of iris in 32% of patients and more than 2 hours of angle in 27%. The ciliary body was involved in 20%. Cataract was present in 13 patients before treatment and subsequently developed in another 18. Cataract had a 4-year rate of 63% and by Cox analysis was related to age (p = 0.05), initial visual loss (p < 0.0001), iris involvement (p < 0.0001), and tumor thickness (p < 0.0001). Glaucoma was present before treatment in 13 patients and developed after treatment in another 3. Three eyes were enucleated, all because of recurrence, which had an actuarial 4-year rate of 3.3% (95% CI 0-8.0%). Conclusions: Proton beam radiotherapy of iris melanoma is well tolerated, the main problems being radiation-cataract, which was treatable, and preexisting glaucoma, which in several patients was difficult to control

  20. Modeling and simulation of a proton beam space-charge neutralization

    International Nuclear Information System (INIS)

    Fleury, Xavier

    2000-01-01

    The aim of this work is to understand and to model the build-up of a plasma in the low-energy beam transport line of a proton accelerator. This plasma is generated by the beam, which ionizes the residual gas remaining in this low-energy section. By neutralizing the space-charge of the beam, the plasma modifies its transport, thus, to control the beam, it is necessary to study this phenomenon. In this work, we consider a continuous beam and we take interest in the stationary states of the plasma. We first restrict the description of the plasma to a plane perpendicular to the beam, by assuming that the beam and the plasma are longitudinally invariant. The build-up of the plasma is first described with a kinetic model where binary collisions are neglected, based on the Vlasov-Poisson system with source terms which take into account ionization. We prove mathematically that this system has no stationary solution, by using appropriate subsets of the phase-space that we call trapping-sets. Yet, measurements show that the plasma evolves towards a steady state. To account for this evolution, we modify the source terms of the model. The resulting model is solved by a particle-in-cell method, and the results are compared to the measurements. Then, we show that binary collisions between plasma electrons and beam ions or gas molecules help to maintain the equilibrium of the plasma. In the last part of the thesis, we use hydrodynamic models to investigate more easily the coupling between transversal and longitudinal effects. The preliminary study of a one-dimensional model enables to find the behaviour of the transverse potential of the plasma. Finally, a two-dimensional model of the transport of the beam when it is neutralized by the plasma is solved numerically, which shows that the longitudinal electric field should play an important role in the set-up of the equilibrium of the plasma. (author) [fr

  1. YAP(Ce) crystal characterization with proton beam up to 60 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Randazzo, N. [Istituto Nazionale di Fisica Nucleare, Sezione di Catania (I), Via S. Sofia, 64-I-95123 Catania (Italy)], E-mail: nunzio.randazzo@ct.infn.it; Sipala, V.; Aiello, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Catania (I), Via S. Sofia, 64-I-95123 Catania (Italy); Lo Presti, D. [Istituto Nazionale di Fisica Nucleare, Sezione di Catania (I), Via S. Sofia, 64-I-95123 Catania (Italy); Dipartimento di Fisica e Astronomia, Universita di Catania, Catania (Italy); Cirrone, G.A.P.; Cuttone, G.; Di Rosa, F. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud (Italy)

    2008-02-21

    A YAP(Ce) crystal was characterized with a proton beam up to 60 MeV. Tests were performed to investigate the possibility of using this detector as a proton calorimeter. The size of the crystal was chosen so that the proton energy is totally lost inside the medium. The authors propose to use the YAP(Ce) crystal in medical applications for proton therapy. In particular, in proton computed tomography (pCT) project it is necessary as a calorimeter in order to measure the proton residual energy after the phantom. Energy resolution, linearity, and light yield were measured in the Laboratori Nazionali del Sud with the CATANA proton beam [ (http://www.lns.infn.it/CATANA/CATANA)] and the results are shown in this paper. The crystal shows a good resolution (3% at 60 MeV proton beam) and it shows good linearity for different proton beam energies (1% at 30-60 MeV energy range). The crystal performances confirm that the YAP(Ce) crystal represents a good solution for these kinds of application.

  2. YAP(Ce) crystal characterization with proton beam up to 60 MeV

    International Nuclear Information System (INIS)

    Randazzo, N.; Sipala, V.; Aiello, S.; Lo Presti, D.; Cirrone, G.A.P.; Cuttone, G.; Di Rosa, F.

    2008-01-01

    A YAP(Ce) crystal was characterized with a proton beam up to 60 MeV. Tests were performed to investigate the possibility of using this detector as a proton calorimeter. The size of the crystal was chosen so that the proton energy is totally lost inside the medium. The authors propose to use the YAP(Ce) crystal in medical applications for proton therapy. In particular, in proton computed tomography (pCT) project it is necessary as a calorimeter in order to measure the proton residual energy after the phantom. Energy resolution, linearity, and light yield were measured in the Laboratori Nazionali del Sud with the CATANA proton beam [ (http://www.lns.infn.it/CATANA/CATANA)] and the results are shown in this paper. The crystal shows a good resolution (3% at 60 MeV proton beam) and it shows good linearity for different proton beam energies (1% at 30-60 MeV energy range). The crystal performances confirm that the YAP(Ce) crystal represents a good solution for these kinds of application

  3. YAP(Ce) crystal characterization with proton beam up to 60 MeV

    Science.gov (United States)

    Randazzo, N.; Sipala, V.; Aiello, S.; Lo Presti, D.; Cirrone, G. A. P.; Cuttone, G.; Di Rosa, F.

    2008-02-01

    A YAP(Ce) crystal was characterized with a proton beam up to 60 MeV. Tests were performed to investigate the possibility of using this detector as a proton calorimeter. The size of the crystal was chosen so that the proton energy is totally lost inside the medium. The authors propose to use the YAP(Ce) crystal in medical applications for proton therapy. In particular, in proton computed tomography (pCT) project it is necessary as a calorimeter in order to measure the proton residual energy after the phantom. Energy resolution, linearity, and light yield were measured in the Laboratori Nazionali del Sud with the CATANA proton beam [ http://www.lns.infn.it/CATANA/CATANA] and the results are shown in this paper. The crystal shows a good resolution (3% at 60 MeV proton beam) and it shows good linearity for different proton beam energies (1% at 30-60 MeV energy range). The crystal performances confirm that the YAP(Ce) crystal represents a good solution for these kinds of application.

  4. Measuring proton beam thermal noises on the NAP-M storage ring

    International Nuclear Information System (INIS)

    Dement'ev, E.N.; Dikanskij, N.S.; Medvedko, A.S.; Parkhomchuk, V.V.; Pestrikov, D.V.

    1980-01-01

    The data on experimental investigation of thermal noises of an asimuthally homogeneous proton beam on the NAP-M storage ring are given. The noise spectra are measured at the 5th and 8th harmonics of the ciculation frequency using pick-up electrodes. The dependencies of the noise power on the proton current for noncooled and cooled beams are presented. It is shown that as a result of electron cooling the noise power decreases by two orders and in the 0.5-10 μA current range the noise power of the cooled beam does not depend on the proton current. The noise power of the noncooled beam linearly increases with the proton current. It is also shown that with the modulation growth the noise power increases. The conclusions are made that while analyzing noises of the continuous beam in the storage ring the changes of the noise spectra due to particle interaction in the beam should be taken into account

  5. How It's Made - Polarized Proton Beam (444th Brookhaven Lecture)

    International Nuclear Information System (INIS)

    Zelenski, Anatoli

    2008-01-01

    Experiments with polarized beams at RHIC will provide fundamental tests of QCD, and the electro-weak interaction reveal the spin structure of the proton. Polarization asymmetries and parity violation are the strong signatures for identification of the fundamental processes, which are otherwise inaccessible. Such experiments require the maximum available luminosity and therefore polarization must be obtained as an extra beam quality without sacrificing intensity. There are proposals to polarize the high-energy proton beam in the storage rings by the Stern-Gerlach effect or spin-filter techniques. But so far, the only practically available option is acceleration of the polarized beam produced in the source and taking care of polarization survival during acceleration and storage. Two major innovations -- the 'Siberian Snake' technique for polarization preservation during acceleration and high current polarized proton sources make spin physics with the high-energy polarized beams feasible. The RHIC is the first high-energy collider, where the 'Siberian Snake' technique allowed of polarized proton beam acceleration up-to 250 GeV energy. The RHIC unique Optically Pumped Polarized Ion Source produces sufficient polarized beam intensity for complete saturation of the RHIC acceptance. This polarization technique is based on spin-transfer collisions between a proton or atomic hydrogen beam of a few keV beam energy and optically pumped alkali metal vapors. From the first proposal and feasibility studies to the operational source this development can be considered as example of successful unification of individual scientists ingenuity, international collaboration and modern technology application for creation of a new polarization technique, which allowed of two-to-three order of magnitude polarized beam intensity increase sufficient for loading the RHIC to its full capacity for polarization studies.

  6. Studies of scintillator response to 60 MeV protons in a proton beam imaging system

    Directory of Open Access Journals (Sweden)

    Rydygier Marzena

    2015-09-01

    Full Text Available A Proton Beam Imaging System (ProBImS is under development at the Institute of Nuclear Physics, Polish Academy of Sciences (IFJ PAN. The ProBImS will be used to optimize beam delivery at IFJ PAN proton therapy facilities, delivering two-dimensional distributions of beam profiles. The system consists of a scintillator, optical tract and a sensitive CCD camera which digitally records the light emitted from the proton-irradiated scintillator. The optical system, imaging data transfer and control software have already been developed. Here, we report preliminary results of an evaluation of the DuPont Hi-speed thick back screen EJ 000128 scintillator to determine its applicability in our imaging system. In order to optimize the light conversion with respect to the dose locally deposited by the proton beam in the scintillation detector, we have studied the response of the DuPont scintillator in terms of linearity of dose response, uniformity of light emission and decay rate of background light after deposition of a high dose in the scintillator. We found a linear dependence of scintillator light output vs. beam intensity by showing the intensity of the recorded images to be proportional to the dose deposited in the scintillator volume.

  7. EPR/alanine dosimetry for two therapeutic proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Marrale, Maurizio, E-mail: maurizio.marrale@unipa.it [Dipartimento di Fisica e Chimica, Università di Palermo, Viale delle Scienze, Edificio 18, 90128 Palermo (Italy); Gruppo V Sezione INFN di Catania, Via Santa Sofia, 64, 95123 Catania (Italy); Carlino, Antonio [Dipartimento di Fisica e Chimica, Università di Palermo, Viale delle Scienze, Edificio 18, 90128 Palermo (Italy); EBG MedAustron GmbH, Marie Curie-Straße 5, A-2700 Wiener Neustadt (Austria); Gallo, Salvatore [Dipartimento di Fisica e Chimica, Università di Palermo, Viale delle Scienze, Edificio 18, 90128 Palermo (Italy); Gruppo V Sezione INFN di Catania, Via Santa Sofia, 64, 95123 Catania (Italy); Laboratorio PH3DRA, Dipartimento di Fisica e Astronomia, Università di Catania, Via Santa Sofia 64, 95123 Catania (Italy); Longo, Anna; Panzeca, Salvatore [Dipartimento di Fisica e Chimica, Università di Palermo, Viale delle Scienze, Edificio 18, 90128 Palermo (Italy); Gruppo V Sezione INFN di Catania, Via Santa Sofia, 64, 95123 Catania (Italy); Bolsi, Alessandra; Hrbacek, Jan; Lomax, Tony [Center for Proton Therapy, Paul Scherrer Institute, 5232 Villigen PSI (Switzerland)

    2016-02-01

    In this work the analysis of the electron paramagnetic resonance (EPR) response of alanine pellets exposed to two different clinical proton beams employed for radiotherapy is performed. One beam is characterized by a passive delivery technique and is dedicated to the eyes treatment (OPTIS2 beam line). Alanine pellets were irradiated with a 70 MeV proton beam corresponding to 35 mm range in eye tissue. We investigated how collimators with different sizes and shape used to conform the dose to the planned target volume influence the delivered dose. For this purpose we performed measurements with varying the collimator size (Output Factor) and the results were compared with those obtained with other dosimetric techniques (such as Markus chamber and diode detector). This analysis showed that the dosimeter response is independent of collimator diameter if this is larger than or equal to 10 mm. The other beam is characterized by an active spot-scanning technique, the Gantry1 beam line (maximum energy 230 MeV), and is used to treat deep-seated tumors. The dose linearity of alanine response in the clinical dose range was tested and the alanine dose response at selected locations in depth was measured and compared with the TPS planned dose in a quasi-clinical scenario. The alanine response was found to be linear in the dose in the clinical explored range (from 10 to 70 Gy). Furthermore, a depth dose profile in a quasi-clinical scenario was measured and compared to the dose computed by the Treatment Planning System PSIPLAN. The comparison of calibrated proton alanine measurements and TPS dose shows a difference under 1% in the SOBP and a “quenching” effect up to 4% in the distal part of SOBP. The positive dosimetric characteristics of the alanine pellets confirm the feasibility to use these detectors for “in vivo” dosimetry in clinical proton beams.

  8. EPR/alanine dosimetry for two therapeutic proton beams

    International Nuclear Information System (INIS)

    Marrale, Maurizio; Carlino, Antonio; Gallo, Salvatore; Longo, Anna; Panzeca, Salvatore; Bolsi, Alessandra; Hrbacek, Jan; Lomax, Tony

    2016-01-01

    In this work the analysis of the electron paramagnetic resonance (EPR) response of alanine pellets exposed to two different clinical proton beams employed for radiotherapy is performed. One beam is characterized by a passive delivery technique and is dedicated to the eyes treatment (OPTIS2 beam line). Alanine pellets were irradiated with a 70 MeV proton beam corresponding to 35 mm range in eye tissue. We investigated how collimators with different sizes and shape used to conform the dose to the planned target volume influence the delivered dose. For this purpose we performed measurements with varying the collimator size (Output Factor) and the results were compared with those obtained with other dosimetric techniques (such as Markus chamber and diode detector). This analysis showed that the dosimeter response is independent of collimator diameter if this is larger than or equal to 10 mm. The other beam is characterized by an active spot-scanning technique, the Gantry1 beam line (maximum energy 230 MeV), and is used to treat deep-seated tumors. The dose linearity of alanine response in the clinical dose range was tested and the alanine dose response at selected locations in depth was measured and compared with the TPS planned dose in a quasi-clinical scenario. The alanine response was found to be linear in the dose in the clinical explored range (from 10 to 70 Gy). Furthermore, a depth dose profile in a quasi-clinical scenario was measured and compared to the dose computed by the Treatment Planning System PSIPLAN. The comparison of calibrated proton alanine measurements and TPS dose shows a difference under 1% in the SOBP and a “quenching” effect up to 4% in the distal part of SOBP. The positive dosimetric characteristics of the alanine pellets confirm the feasibility to use these detectors for “in vivo” dosimetry in clinical proton beams.

  9. Capacitive beam position monitors for the low-β beam of the Chinese ADS proton linac

    Science.gov (United States)

    Zhang, Yong; Wu, Jun-Xia; Zhu, Guang-Yu; Jia, Huan; Xue, Zong-Heng; Zheng, Hai; Xie, Hong-Ming; Kang, Xin-Cai; He, Yuan; Li, Lin; Denard, Jean Claude

    2016-02-01

    Beam Position Monitors (BPMs) for the low-β beam of the Chinese Accelerator Driven Subcritical system (CADS) Proton linac are of the capacitive pick-up type. They provide higher output signals than that of the inductive type. This paper will describe the design and tests of the capacitive BPM system for the low-β proton linac, including the pick-ups, the test bench and the read-out electronics. The tests done with an actual proton beam show a good agreement between the measurements and the simulations in the time domain. Supported by National Natural Science Foundation of China (11405240) and “Western Light” Talents Training Program of Chinese Academy of Sciences

  10. A Fano cavity test for Monte Carlo proton transport algorithms

    International Nuclear Information System (INIS)

    Sterpin, Edmond; Sorriaux, Jefferson; Souris, Kevin; Vynckier, Stefaan; Bouchard, Hugo

    2014-01-01

    Purpose: In the scope of reference dosimetry of radiotherapy beams, Monte Carlo (MC) simulations are widely used to compute ionization chamber dose response accurately. Uncertainties related to the transport algorithm can be verified performing self-consistency tests, i.e., the so-called “Fano cavity test.” The Fano cavity test is based on the Fano theorem, which states that under charged particle equilibrium conditions, the charged particle fluence is independent of the mass density of the media as long as the cross-sections are uniform. Such tests have not been performed yet for MC codes simulating proton transport. The objectives of this study are to design a new Fano cavity test for proton MC and to implement the methodology in two MC codes: Geant4 and PENELOPE extended to protons (PENH). Methods: The new Fano test is designed to evaluate the accuracy of proton transport. Virtual particles with an energy ofE 0 and a mass macroscopic cross section of (Σ)/(ρ) are transported, having the ability to generate protons with kinetic energy E 0 and to be restored after each interaction, thus providing proton equilibrium. To perform the test, the authors use a simplified simulation model and rigorously demonstrate that the computed cavity dose per incident fluence must equal (ΣE 0 )/(ρ) , as expected in classic Fano tests. The implementation of the test is performed in Geant4 and PENH. The geometry used for testing is a 10 × 10 cm 2 parallel virtual field and a cavity (2 × 2 × 0.2 cm 3 size) in a water phantom with dimensions large enough to ensure proton equilibrium. Results: For conservative user-defined simulation parameters (leading to small step sizes), both Geant4 and PENH pass the Fano cavity test within 0.1%. However, differences of 0.6% and 0.7% were observed for PENH and Geant4, respectively, using larger step sizes. For PENH, the difference is attributed to the random-hinge method that introduces an artificial energy straggling if step size is not

  11. High quality proton beams from hybrid integrated laser-driven ion acceleration systems

    Energy Technology Data Exchange (ETDEWEB)

    Sinigardi, Stefano, E-mail: sinigardi@bo.infn.it [Dipartimento di Fisica e Astronomia, Università di Bologna and INFN Sezione di Bologna, Via Irnerio 46, I-40126 Bologna (Italy); Turchetti, Giorgio; Rossi, Francesco; Londrillo, Pasquale [Dipartimento di Fisica e Astronomia, Università di Bologna and INFN Sezione di Bologna, Via Irnerio 46, I-40126 Bologna (Italy); Giove, Dario; De Martinis, Carlo [Dipartimento di Fisica, Università di Milano and INFN Sezione di Milano, Via F.lli Cervi 201, I-20090 Segrate (Italy); Bolton, Paul R. [Kansai Photon Science Institute (JAEA), Umemidai 8-1-7, Kizugawa-shi, Kyoto 619-0215 (Japan)

    2014-03-11

    We consider a hybrid acceleration scheme for protons where the laser generated beam is selected in energy and angle and injected into a compact linac, which raises the energy from 30 to 60 MeV. The laser acceleration regime is TNSA and the energy spectrum is determined by the cutoff energy and proton temperature. The dependence of the spectrum on the target properties and the incidence angle is investigated with 2D PIC simulations. We base our work on widely available technologies and on laser with a short pulse, having in mind a facility whose cost is approximately 15M€. Using a recent experiment as the reference, we choose the laser pulse and target so that the energy spectrum obtained from the 3D PIC simulation is close to the one observed, whose cutoff energy was estimated to be over 50 MeV. Laser accelerated protons in the TNSA regime have wide energy spectrum and broad divergence. In this paper we compare three transport lines, designed to perform energy selection and beam collimation. They are based on a solenoid, a quadruplet of permanent magnetic quadrupoles and a chicane. To increase the maximum available energy, which is actually seen as an upper limit due to laser properties and available targets, we propose to inject protons into a small linac for post-acceleration. The number of selected and injected protons is the highest with the solenoid and lower by one and two orders of magnitude with the quadrupoles and the chicane respectively. Even though only the solenoid enables achieving to reach a final intensity at the threshold required for therapy with the highest beam quality, the other systems will be very likely used in the first experiments. Realistic start-to-end simulations, as the ones reported here, are relevant for the design of such experiments.

  12. High quality proton beams from hybrid integrated laser-driven ion acceleration systems

    Science.gov (United States)

    Sinigardi, Stefano; Turchetti, Giorgio; Rossi, Francesco; Londrillo, Pasquale; Giove, Dario; De Martinis, Carlo; Bolton, Paul R.

    2014-03-01

    We consider a hybrid acceleration scheme for protons where the laser generated beam is selected in energy and angle and injected into a compact linac, which raises the energy from 30 to 60 MeV. The laser acceleration regime is TNSA and the energy spectrum is determined by the cutoff energy and proton temperature. The dependence of the spectrum on the target properties and the incidence angle is investigated with 2D PIC simulations. We base our work on widely available technologies and on laser with a short pulse, having in mind a facility whose cost is approximately 15 M €. Using a recent experiment as the reference, we choose the laser pulse and target so that the energy spectrum obtained from the 3D PIC simulation is close to the one observed, whose cutoff energy was estimated to be over 50 MeV. Laser accelerated protons in the TNSA regime have wide energy spectrum and broad divergence. In this paper we compare three transport lines, designed to perform energy selection and beam collimation. They are based on a solenoid, a quadruplet of permanent magnetic quadrupoles and a chicane. To increase the maximum available energy, which is actually seen as an upper limit due to laser properties and available targets, we propose to inject protons into a small linac for post-acceleration. The number of selected and injected protons is the highest with the solenoid and lower by one and two orders of magnitude with the quadrupoles and the chicane respectively. Even though only the solenoid enables achieving to reach a final intensity at the threshold required for therapy with the highest beam quality, the other systems will be very likely used in the first experiments. Realistic start-to-end simulations, as the ones reported here, are relevant for the design of such experiments.

  13. High quality proton beams from hybrid integrated laser-driven ion acceleration systems

    International Nuclear Information System (INIS)

    Sinigardi, Stefano; Turchetti, Giorgio; Rossi, Francesco; Londrillo, Pasquale; Giove, Dario; De Martinis, Carlo; Bolton, Paul R.

    2014-01-01

    We consider a hybrid acceleration scheme for protons where the laser generated beam is selected in energy and angle and injected into a compact linac, which raises the energy from 30 to 60 MeV. The laser acceleration regime is TNSA and the energy spectrum is determined by the cutoff energy and proton temperature. The dependence of the spectrum on the target properties and the incidence angle is investigated with 2D PIC simulations. We base our work on widely available technologies and on laser with a short pulse, having in mind a facility whose cost is approximately 15M€. Using a recent experiment as the reference, we choose the laser pulse and target so that the energy spectrum obtained from the 3D PIC simulation is close to the one observed, whose cutoff energy was estimated to be over 50 MeV. Laser accelerated protons in the TNSA regime have wide energy spectrum and broad divergence. In this paper we compare three transport lines, designed to perform energy selection and beam collimation. They are based on a solenoid, a quadruplet of permanent magnetic quadrupoles and a chicane. To increase the maximum available energy, which is actually seen as an upper limit due to laser properties and available targets, we propose to inject protons into a small linac for post-acceleration. The number of selected and injected protons is the highest with the solenoid and lower by one and two orders of magnitude with the quadrupoles and the chicane respectively. Even though only the solenoid enables achieving to reach a final intensity at the threshold required for therapy with the highest beam quality, the other systems will be very likely used in the first experiments. Realistic start-to-end simulations, as the ones reported here, are relevant for the design of such experiments

  14. Manufacturing of Three-dimensional Micro Structure Using Proton Beam

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Suonggyu; Kwon, Wontae [Seoul University, Seoul (Korea, Republic of)

    2015-04-15

    The diameter of a proton beam emanating from the MC-50 cyclotron is about 2?3 mm with Gaussian distribution. This widely irradiated proton beam is not suitable for semiconductor etching, precise positioning, and micromachining, which require a small spot. In this study, a beam cutting method using a microhole is proposed as an economical alternative. We produced a microhole with aspect ratio, average diameter, and thickness of 428, 21 μm, and 9 mm, respectively, for cutting the proton beam. By using this high-aspect-ratio microhole, we conducted machinability tests on microstructures with sizes of tens of μm. Additionally, the results of simulation using GEANT4 and those of the actual experiment were compared and analyzed. The outcome confirmed the possibility of implementing a micro process technology for the fabrication of three-dimensional microstructures of 20 micron units using the MC-50 cyclotron with the microhole.

  15. Beam intensity monitoring for the external proton beam at LAMPF

    International Nuclear Information System (INIS)

    Barrett, R.J.; Anderson, B.D.; Willard, H.B.; Anderson, A.N.; Jarmie, N.

    1975-07-01

    Three different intensity monitors were tested in the external proton beam at LAMPF, and together cover the entire range of beam currents available. A 800 kg Faraday cup was installed and used to measure the absolute intensity to better than 1 percent for beam currents up to several nanoamperes. A high gain ion chamber was used as part of the calibration procedure for the Faraday cup, and was found to be useful when monitoring very small beam intensities, being reliable down to the few picoampere level. A secondary emission monitor was also tested, calibrated, and found to be trustworthy only for beams of greater than 50 pA intensity. (auth)

  16. Binary codes storage and data encryption in substrates with single proton beam writing technology

    International Nuclear Information System (INIS)

    Zhang Jun; Zhan Furu; Hu Zhiwen; Chen Lianyun; Yu Zengliang

    2006-01-01

    It has been demonstrated that characters can be written by proton beams in various materials. In contributing to the rapid development of proton beam writing technology, we introduce a new method for binary code storage and data encryption by writing binary codes of characters (BCC) in substrates with single proton beam writing technology. In this study, two kinds of BCC (ASCII BCC and long bit encrypted BCC) were written in CR-39 by a 2.6 MeV single proton beam. Our results show that in comparison to directly writing character shapes, writing ASCII BCC turned out to be about six times faster and required about one fourth the area in substrates. The approach of writing long bit encrypted BCC by single proton beams supports preserving confidential information in substrates. Additionally, binary codes fabricated by MeV single proton beams in substrates are more robust than those formed by lasers, since MeV single proton beams can make much deeper pits in the substrates

  17. Shielding calculation of slow extracted beam facility at KEK proton synchrotron

    International Nuclear Information System (INIS)

    Hirabayashi, Hiromi; Katoh, Kazuaki

    1978-01-01

    The KEK proton synchrotron has two external beam lines, i.e. a fast extracted beam line for a bubble chamber and a slow extracted beam line for counter experiments. The maximum total intensity of the slow beam is estimated as 5 x 10 12 protons per sec. For beam losses along the line, shielding calculation was made, and on the basis of these results, adequacy of the current shielding construction plans was discussed. (Mori, K.)

  18. Induction of cancer cell death by proton beam in tumor hypoxic region

    International Nuclear Information System (INIS)

    Hur, T. R.; Lee, Y. M.; Park, J. W.; Sohn, E. J.

    2006-05-01

    The physical properties of charged particles such as protons are uniquely suited to target the radiation dose precisely in the tumor. In proton therapy, the Bragg peak is spread out by modulating or degrading the energy of the particles to cover a well defined target volume at a given depth. Due to heterogeneity in the various tumors and end-points as well as in the physical properties of the beams considered, it is difficult to fit the various results into a clear general description of the biological effect of proton in tumor therapy. Tumor hypoxia is a main obstacle to radiotherapy, including gamma-ray. Survived tumor cells under hypoxic region are resistant to radiation and more aggressive to be metastasized. To investigate the dose of proton beam to induce cell death of various tumor cells and hypoxic tumor cells at the Bragg peak in vitro, we used 3 kinds of tumor cells, lung cancer, leukemia and hepatoma cells. Proton beam induces apoptosis in Lewis lung carcinoma cells dose dependently and, slightly in leukemia but not in hepatoma cells at all. Above 1000 gray of proton beam, 60% of cells died even the hypoxic cells in Lewis lung carcinoma cells. But the Molt-4 leukemia cells showed milder effect, 20% cell death by the above 1000 Gray of proton beam and typical resistant pattern (5-10%) of hypoxia in desferrioxamine treated cells. Hepatoma cells (HepG2) were not responsive to proton beam even in rather higher dose (4000G). However, by the gamma-irradiation, Molt-4 was more sensitive than hepatoma or lung cancer cells, but still showed hypoxic resistance. The cell death by proton beam in Lewis lung carcinoma cells was confirmed by PARP cleavage and may be mediated by increased p53. Pro-caspases were also activated and cleaved by the proton beam irradiations for lung cancer cell death. In conclusion, high dose of proton beam (above 1000 gray) may be a good therapeutic radiation even in hypoxic region at the Bragg peak, but further investigations about the

  19. A Liquid Scintillator System for Dosimetry of Photon and Proton Beams

    International Nuclear Information System (INIS)

    Beddar S

    2010-01-01

    We have developed a 3D system based on liquid scintillator (LS) for the dosimetry of photon and proton therapy. We have validated the LS detector system for fast and accurate quality assurance of IMRT and proton therapy fields. Further improvements are required to optimize the quantitative analysis of the light output provided by the system in photon beams. We have also demonstrated its usefulness for protons as it can determine the position and the range of proton beams. This system has also been shown to be capable of fast, sub-millimeter spatial localization of proton spots delivered in a 3D volume and could be used for quality assurance of IMPT. Further developments are on-going to measure beam intensities in 3D.

  20. Review of medical radiography and tomography with proton beams

    Science.gov (United States)

    Johnson, Robert P.

    2018-01-01

    The use of hadron beams, especially proton beams, in cancer radiotherapy has expanded rapidly in the past two decades. To fully realize the advantages of hadron therapy over traditional x-ray and gamma-ray therapy requires accurate positioning of the Bragg peak throughout the tumor being treated. A half century ago, suggestions had already been made to use protons themselves to develop images of tumors and surrounding tissue, to be used for treatment planning. The recent global expansion of hadron therapy, coupled with modern advances in computation and particle detection, has led several collaborations around the world to develop prototype detector systems and associated reconstruction codes for proton computed tomography (pCT), as well as more simple proton radiography, with the ultimate intent to use such systems in clinical treatment planning and verification. Recent imaging results of phantoms in hospital proton beams are encouraging, but many technical and programmatic challenges remain to be overcome before pCT scanners will be introduced into clinics. This review introduces hadron therapy and the perceived advantages of pCT and proton radiography for treatment planning, reviews its historical development, and discusses the physics related to proton imaging, the associated experimental and computation issues, the technologies used to attack the problem, contemporary efforts in detector and computational development, and the current status and outlook.

  1. MO-A-BRD-10: A Fast and Accurate GPU-Based Proton Transport Monte Carlo Simulation for Validating Proton Therapy Treatment Plans

    Energy Technology Data Exchange (ETDEWEB)

    Wan Chan Tseung, H; Ma, J; Beltran, C [Mayo Clinic, Rochester, MN (United States)

    2014-06-15

    Purpose: To build a GPU-based Monte Carlo (MC) simulation of proton transport with detailed modeling of elastic and non-elastic (NE) protonnucleus interactions, for use in a very fast and cost-effective proton therapy treatment plan verification system. Methods: Using the CUDA framework, we implemented kernels for the following tasks: (1) Simulation of beam spots from our possible scanning nozzle configurations, (2) Proton propagation through CT geometry, taking into account nuclear elastic and multiple scattering, as well as energy straggling, (3) Bertini-style modeling of the intranuclear cascade stage of NE interactions, and (4) Simulation of nuclear evaporation. To validate our MC, we performed: (1) Secondary particle yield calculations in NE collisions with therapeutically-relevant nuclei, (2) Pencil-beam dose calculations in homogeneous phantoms, (3) A large number of treatment plan dose recalculations, and compared with Geant4.9.6p2/TOPAS. A workflow was devised for calculating plans from a commercially available treatment planning system, with scripts for reading DICOM files and generating inputs for our MC. Results: Yields, energy and angular distributions of secondaries from NE collisions on various nuclei are in good agreement with the Geant4.9.6p2 Bertini and Binary cascade models. The 3D-gamma pass rate at 2%–2mm for 70–230 MeV pencil-beam dose distributions in water, soft tissue, bone and Ti phantoms is 100%. The pass rate at 2%–2mm for treatment plan calculations is typically above 98%. The net computational time on a NVIDIA GTX680 card, including all CPU-GPU data transfers, is around 20s for 1×10{sup 7} proton histories. Conclusion: Our GPU-based proton transport MC is the first of its kind to include a detailed nuclear model to handle NE interactions on any nucleus. Dosimetric calculations demonstrate very good agreement with Geant4.9.6p2/TOPAS. Our MC is being integrated into a framework to perform fast routine clinical QA of pencil-beam

  2. Development of a reusable beam profile analyzer for laser accelerated proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Frydrych, Simon; Busold, Simon; Deppert, Oliver; Roth, Markus [Technische Univ. Darmstadt (Germany). Inst. fuer Kernphysik

    2013-07-01

    At the GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, proton beams are generated with the PHELIX laser system through target normal sheath acceleration (TNSA). Within 1 ps, 10{sup 13} protons are produced with an exponential energy spectrum up to 50 MeV. For characterisation, the spatial beam profile is currently detected by a stack of radiochromatic films (RCF). These are blued depending on the beam intensity. One disadvantage of RCFs is its one-time usability. Therefore, they shall be replaced by a scintillator array. To ensure the longest possible shelf life of this new detector, the scintillator material used must be very robust against radiation damage. Also a point of current research is the maximal amount of particles, which can be detected separately.

  3. Thermomechanical response of Large Hadron Collider collimators to proton and ion beam impacts

    Directory of Open Access Journals (Sweden)

    Marija Cauchi

    2015-04-01

    Full Text Available The CERN Large Hadron Collider (LHC is designed to accelerate and bring into collision high-energy protons as well as heavy ions. Accidents involving direct beam impacts on collimators can happen in both cases. The LHC collimation system is designed to handle the demanding requirements of high-intensity proton beams. Although proton beams have 100 times higher beam power than the nominal LHC lead ion beams, specific problems might arise in case of ion losses due to different particle-collimator interaction mechanisms when compared to protons. This paper investigates and compares direct ion and proton beam impacts on collimators, in particular tertiary collimators (TCTs, made of the tungsten heavy alloy INERMET® 180. Recent measurements of the mechanical behavior of this alloy under static and dynamic loading conditions at different temperatures have been done and used for realistic estimates of the collimator response to beam impact. Using these new measurements, a numerical finite element method (FEM approach is presented in this paper. Sequential fast-transient thermostructural analyses are performed in the elastic-plastic domain in order to evaluate and compare the thermomechanical response of TCTs in case of critical beam load cases involving proton and heavy ion beam impacts.

  4. Dosimetry of medical proton beams at the JINR phasotron in Dubna

    International Nuclear Information System (INIS)

    Kovar, I.; Spurny, F.; Wagner, R.; Molokanov, A.G.; Mitsyn, G.V.; Zorin, V.P.

    1993-01-01

    The method for determination of the dose rate absorbed by tissue for JINR phasotron medical proton beams on a basis of clinical dosimeter calibration with the 60 Co γ-source, the main parameters of detectors used for measurements of spatial dose distributions, results of ion recombination correction factors in air thimble ionization chambers measurements are described. It is found that the error of JINR phasotron proton beams dosimetry is about 5%. This accuracy meets the international requirements for the therapeutic proton beams. 15 refs.; 4 figs

  5. Impact of beam angle choice on pencil beam scanning breath-hold proton therapy for lung lesions

    DEFF Research Database (Denmark)

    Gorgisyan, Jenny; Perrin, Rosalind; Lomax, Antony J

    2017-01-01

    INTRODUCTION: The breath-hold technique inter alia has been suggested to mitigate the detrimental effect of motion on pencil beam scanned (PBS) proton therapy dose distributions. The aim of this study was to evaluate the robustness of incident proton beam angles to day-to-day anatomical variation...

  6. High Intensity Beam Issues in the CERN Proton Synchrotron

    CERN Document Server

    Aumon, Sandra; Rivkin, Leonid

    This PhD work is about limitations of high intensity proton beams observed in the CERN Proton Synchrotron (PS) and, in particular, about issues at injection and transition energies. With its 53 years, the CERN PS would have to operate beyond the limit of its performance to match the future requirements. Beam instabilities driven by transverse impedance and aperture restrictions are important issues for the operation and for the High-Luminosity LHC upgrade which foresees an intensity increase delivered by the injectors. The main subject of the thesis concerns the study of a fast transverse instability occurring at transition energy. The proton beams crossing this energy range are particularly sensitive to wake forces because of the slow synchrotron motion. This instability can cause a strong vertical emittance blow-up and severe losses in less than a synchrotron period. Experimental observations show that the particles at the peak density of the beam longitudinal distribution oscillate in the vertical plane du...

  7. Low energy beam transport for HIDIF

    International Nuclear Information System (INIS)

    Meusel, O.; Pozimski, J.; Jakob, A.; Lakatos, A.

    2001-01-01

    Low energy beam transport (LEBT) for a heavy ion inertial fusion (HIDIF, I. Hofmann and G. Plass, Report of the European Study Group on Heavy Ion Driven Inertial Fusion for the Period 1995-1998) facility suffers from high space charge forces and high ion mass. Space charge compensation reduces the necessary focusing force of the lenses and the radius of the beam in the LEBT, and therefrom the emittance growth due to aberrations and self fields is reduced. Gabor lenses (D. Gabor, Nature 160 (1947)) providing a stable space charge cloud for focusing and combine strong cylinder symmetric focusing with partly space charge compensation and low emittance growth. A high tolerance against source noise and current fluctuations and reduced investment costs could be other possible advantages. The proof of principle has already been demonstrated (J.A. Palkovic, Measurements on a Gabor lens for Neutralizing and Focusing a 30 keV Proton beam, University of Wisconsin, Madison, 1989; J. Pozimski, P. Gross, R. Doelling and T. Weis, First experimental studies of a Gabor plasma-lens in Frankfurt, Proceedings of the 3rd EPAC Conference, Berlin, 1992). To broaden the experiences and to investigate the realisation of a LEBT concept for the HIDIF injector an experimental program using two Gabor lenses for independent variation of beam radius and envelope angel at RFQ injection was started. Therefrom the first experimental results using a double Gabor lens (DGPL) LEBT system for transporting an high perveance Xe + beam are presented and the results of numerical simulations are shown

  8. Low energy beam transport for HIDIF

    Energy Technology Data Exchange (ETDEWEB)

    Meusel, O. E-mail: o.meusel@iap.uni-frankfurt.de; Pozimski, J.; Jakob, A.; Lakatos, A

    2001-05-21

    Low energy beam transport (LEBT) for a heavy ion inertial fusion (HIDIF, I. Hofmann and G. Plass, Report of the European Study Group on Heavy Ion Driven Inertial Fusion for the Period 1995-1998) facility suffers from high space charge forces and high ion mass. Space charge compensation reduces the necessary focusing force of the lenses and the radius of the beam in the LEBT, and therefrom the emittance growth due to aberrations and self fields is reduced. Gabor lenses (D. Gabor, Nature 160 (1947)) providing a stable space charge cloud for focusing and combine strong cylinder symmetric focusing with partly space charge compensation and low emittance growth. A high tolerance against source noise and current fluctuations and reduced investment costs could be other possible advantages. The proof of principle has already been demonstrated (J.A. Palkovic, Measurements on a Gabor lens for Neutralizing and Focusing a 30 keV Proton beam, University of Wisconsin, Madison, 1989; J. Pozimski, P. Gross, R. Doelling and T. Weis, First experimental studies of a Gabor plasma-lens in Frankfurt, Proceedings of the 3rd EPAC Conference, Berlin, 1992). To broaden the experiences and to investigate the realisation of a LEBT concept for the HIDIF injector an experimental program using two Gabor lenses for independent variation of beam radius and envelope angel at RFQ injection was started. Therefrom the first experimental results using a double Gabor lens (DGPL) LEBT system for transporting an high perveance Xe{sup +} beam are presented and the results of numerical simulations are shown.

  9. Dynamics and adsorption of gas molecules using proton beams

    International Nuclear Information System (INIS)

    Kim, J. Y.; Kim, E. K.; Lee, J. K.

    2008-04-01

    We irradiated nano sized MgO powders and carbon nanotubes by proton beams with energy of 35 MeV for different dosing time and the difference before and after the irradiation was investigated by using NO and Ar gas adsorptions studies. Particular interest was given to the irradiation of proton beams on quasicrystals made with Ti-Zr-Ni to remove the oxygen layer on the surface of the sample. Quasicrystals are known to exhibit a 5-fold rotational symmetry which is theoretically forbidden in a concept of solid state physics, and have a potential applications on large amount of hydrogen loading due to their structural complexity and chemical affinity with hydrogen. The results are summarized as four major accomplishments. 1) Proton irradiated MgO powders demonstrated the increased number of NO atomic layers in a layer-by-layer fashion suggesting that the surface of the sample became homogeneous compare to the pure samples. 2) the synchrotron based X-ray diffraction data suggests that NO molecules form an 1x1 commensurate structure on MgO (100) surface evidenced by the NO peak location at the Q values of 2.12 A -1 . 3) Proton irradiated SWCNTs exhibit the uniform Ar atomic layer formation suggesting that the surface of the CNTs can be homonized by the proton beam irradiation, and 4) 20 MeV of proton beam can effectively remove the oxygen layer on metal oxides so that Ti-Zr-Ni quasicrystals can load a large amount of hydrogen (exceeding to the density of liquid hydrogen) at room temperature.

  10. A Case Study in Proton Pencil-Beam Scanning Delivery

    International Nuclear Information System (INIS)

    Kooy, Hanne M.; Clasie, Benjamin M.; Lu, H.-M.; Madden, Thomas M.; Bentefour, Hassan; Depauw, Nicolas M.S.; Adams, Judy A.; Trofimov, Alexei V.; Demaret, Denis; Delaney, Thomas F.; Flanz, Jacob B.

    2010-01-01

    Purpose: We completed an implementation of pencil-beam scanning (PBS), a technology whereby a focused beam of protons, of variable intensity and energy, is scanned over a plane perpendicular to the beam axis and in depth. The aim of radiotherapy is to improve the target to healthy tissue dose differential. We illustrate how PBS achieves this aim in a patient with a bulky tumor. Methods and Materials: Our first deployment of PBS uses 'broad' pencil-beams ranging from 20 to 35 mm (full-width-half-maximum) over the range interval from 32 to 7 g/cm 2 . Such beam-brushes offer a unique opportunity for treating bulky tumors. We present a case study of a large (4,295 cc clinical target volume) retroperitoneal sarcoma treated to 50.4 Gy relative biological effectiveness (RBE) (presurgery) using a course of photons and protons to the clinical target volume and a course of protons to the gross target volume. Results: We describe our system and present the dosimetry for all courses and provide an interdosimetric comparison. Discussion: The use of PBS for bulky targets reduces the complexity of treatment planning and delivery compared with collimated proton fields. In addition, PBS obviates, especially for cases as presented here, the significant cost incurred in the construction of field-specific hardware. PBS offers improved dose distributions, reduced treatment time, and reduced cost of treatment.

  11. ZGS beam transport for transverse or longitudinally polarized protons

    International Nuclear Information System (INIS)

    Colton, E.; Auer, I.P.; Beretvas, A.

    1977-01-01

    A combination of dipole magnets and a superconducting solenoid is utilized to transform the spin direction of transversely polarized protons from the Argonne ZGS for use in proton-proton scattering experiments

  12. The beam transport system

    International Nuclear Information System (INIS)

    1986-01-01

    The first proton beams have been transported along the transfer beamline and the diagnostic components have thus been used and tested under real operating conditions. The various electronic systems have been linked to the control system and the equipment can now be operated from the control console. The performance of the diagnostic system for the transfer beamline is satisfactory. The beam diagnostic components for the high-energy beamlines up to the isotope production and neutron therapy vaults and the first experimental target rooms have been installed. The high-energy slits have been delivered. The scanner and harp electronics have been installed and linked to their respective components in the beamlines. The pneumatic acuator control electronics has been manufactured, installed and is operational; provision has been made for special control features of the equipment in the therapy beamline. The high-voltage bias supply for the Faraday cups has been implemented. The installation of the beam current measurement system is nearing completion although part of it is already operational. A coaxial relay multiplexer for the capacitive phase probe signals has been manufactured and installed. The diagnostic equipment for the beamlines to isotope production and neutron therapy is thus ready for operation. 4 figs

  13. Target experiments with high-power proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Baumung, K; Bluhm, H; Hoppe, P; Rusch, D; Singer, J; Stoltz, O [Forschungszentrum Karlsruhe (Germany); Kanel, G I; Razorenov, S V; Utkin, A V [Russian Academy of Sciences, Chernogolovka (Russian Federation). Inst. of Chemical Physics

    1997-12-31

    At the Karlsruhe Light Ion Facility KALE a pulsed high-power proton beam (50 ns, 0.15 TW/cm{sup 2}, 8 mm fwhm focus diameter, 1.7 MeV peak proton energy) is used to generate short, intense pressure pulses or to ablatively accelerate targets 10-100 {mu}m thick to velocities > 10 km/s. The velocity history of the rear target surface is recorded by line-imaging laser Doppler velocimetry with high spatial ({>=} 10 {mu}m) and temporal ({>=} 200 ps) resolution, and provides information on proton beam parameters, and on the state of the matter at high energy densities and intense loading. Utilizing the bell-shaped power density profile the authors demonstrated a new straightforward method for measuring the shock pressure that leads to material melting in the rarefaction wave. For the first time, the dynamic tensile strength was measured across a crystal grain boundary, and using targets with a 1D periodic structure, the growth rate of a Rayleigh Taylor instability could be measured for the first time in direct drive experiments with an ion beam. (author). 8 figs., 15 refs.

  14. The study of PDMS surface treatment and it's applications by using proton beam

    International Nuclear Information System (INIS)

    Baek, J. Y.; Kim, J. Y.; Kwon, K. H.; Park, J. Y.

    2007-04-01

    PDMS(Polydimethylsiloxane) is mainly used as a material to do lab on a chip for biochemical analysis. PDMS has many applicability at the Bio-Technology(BT) field, because it is flexible, biocompatible and has good oxygen permeability. In this study, we have investigated to physical and chemical changes of PDMS surface by proton beam radiation conditions. The used kind of ion were Ar and N, beam energy was 30keV, 60keV, 80keV, total fluence was 1E10 to 1E16 [ions/cm 2 ]. PDMS membrane was produced as 150 μm thick on the 3' silicon wafer. We inquired into physical and chemical changes up to beam radiation conditions through the investigate the change of surface roughness by AFM(Atomic Force Microscope), the change of surface morphology by SEM(Scanning Electron Microscope) and the change of chemical composition by FT-IR(Fourier Transform Infrared Raman spectroscopy) and XPS(X-ray Photoelectron Spectroscopy). From these basic data to we set up the proton beam radiation conditions to secure metal layer and PDMS adhesion. This enables to produce the electrode at the PDMS material lab on a chip. From now on, we'll investigate the cell patterning possibility after carry out of cell culture with mouse fibroblast at PDMS surface what is surface modification by using of proton beam radiation and apply this to produce lab on a chip. Physical property: Surface roughness of PDMS membrane was observed using AFM, after exposure of proton beam on it. The roughness increased as the power level of proton beam increase. This phenomena was caused by the kinetic energy of particle. Chemical property: Long term observation was conducted on the contact angles of the samples made by the proton beam exposure or oxygen plasma treatment; the hydrophilicity was found to be stronger in the samples made by the proton beam exposure. We found the reason of this was the destruction of polymer chains by proton beam. Feasibility of Through-hole: Considering that comparatively high level energy beam

  15. VIVITRON beam transport

    International Nuclear Information System (INIS)

    Nadji, A.

    1989-07-01

    The VIVITRON is a new 35 MV particle accelerator which presents a great number of innovations. One of the major problem is the beam transport in this electrostatic machine of 50 m length for ions with masses between 1 and 200. Our work consisted in the study of various experimental and theoretical aspects of the beam transport in Tandem accelerators from the ion source to the analysing magnet. Calculations of the beam optics were performed with a Strasbourg version of the computer code Transport. They allowed us to optimize the beam transport parameters of the VIVITRON elements. Special attention has been focused on the design of the charge state selector to be installed in the terminal of the new machine. Beam transmission measurements were carried out in the Strasbourg MP 10 Tandem accelerator for ions beams of masses between 1 and 127 and for terminal voltages from 9 to 15 MV. Partial and total transmissions were obtained and explanations of the beam losses were proposed in terms of the vacuum pressure and/or the optics of the beam accelerator system. The results have been extrapolated to the VIVITRON for which the best working conditions are now clearly defined [fr

  16. Space charge compensation on the low energy beam transport of Linac4

    CERN Document Server

    AUTHOR|(SzGeCERN)733270; Scrivens, Richard; Jesus Castillo, Santos

    Part of the upgrade program in the injector chains of the CERN accelerator complex is the replacement of the the proton accelerator Linac2 for the brand new Linac4 which will accelerate H$^-$ and its main goal is to increase the beam intensity in the next sections of the LHC accelerator chain. The Linac4 is now under commissioning and will use several ion sources to produce high intensity unbunched H$^-$ beams with different properties, and the low energy beam transport (LEBT) is the system in charge of match all these different beams to the Radio frequency quadrupole (RFQ). The space charge forces that spread the beam ions apart of each other and cause emittance growth limits the maximum intensity that can be transported in the LEBT, but the space charge of intense unbunched ion beams can be compensated by the generated ions by the impact ionization of the residual gas, which creates a source of secondary particles inside the beam pipe. For negative ion beams, the effect of the beam electric field is to ex...

  17. Micro-patterns fabrication using focused proton beam lithography

    Energy Technology Data Exchange (ETDEWEB)

    Cutroneo, M., E-mail: cutroneo@ujf.cas.cz [Nuclear Physics Institute, AS CR, 25068 Rez (Czech Republic); Havranek, V. [Nuclear Physics Institute, AS CR, 25068 Rez (Czech Republic); Mackova, A. [Nuclear Physics Institute, AS CR, 25068 Rez (Czech Republic); Department of Physics, Faculty of Science, J.E. Purkinje University, Ceske mladeze 8, 400 96 Usti nad Labem (Czech Republic); Semian, V. [Nuclear Physics Institute, AS CR, 25068 Rez (Czech Republic); Torrisi, L. [Department of Physics and Earth Sciences, Messina University, V.le F.S. d’Alcontres 31, 98166 S. Agata, Messina (Italy); Calcagno, L. [Department of Physics, Catania University, V. S. Sofia 64, 95123 Catania (Italy)

    2016-03-15

    Proton beam writing technique was recently introduced at 3MV Tandetron accelerator at Nuclear Physics Institute in Rez (Czech Republic). It has been used, to produce three-dimensional (3D) micro-structures in poly(methylmethacrylate) by 2.0 MeV and 2.6 MeV protons micro-beam. Micro-channels (52 μm × 52 μm) have been realized. After chemical etching, the quality of the bottom and side walls of the produced structures in PMMA were analyzed using Scanning Transmission Ion Microscopy (STIM).

  18. Integration and evaluation of automated Monte Carlo simulations in the clinical practice of scanned proton and carbon ion beam therapy.

    Science.gov (United States)

    Bauer, J; Sommerer, F; Mairani, A; Unholtz, D; Farook, R; Handrack, J; Frey, K; Marcelos, T; Tessonnier, T; Ecker, S; Ackermann, B; Ellerbrock, M; Debus, J; Parodi, K

    2014-08-21

    Monte Carlo (MC) simulations of beam interaction and transport in matter are increasingly considered as essential tools to support several aspects of radiation therapy. Despite the vast application of MC to photon therapy and scattered proton therapy, clinical experience in scanned ion beam therapy is still scarce. This is especially the case for ions heavier than protons, which pose additional issues like nuclear fragmentation and varying biological effectiveness. In this work, we present the evaluation of a dedicated framework which has been developed at the Heidelberg Ion Beam Therapy Center to provide automated FLUKA MC simulations of clinical patient treatments with scanned proton and carbon ion beams. Investigations on the number of transported primaries and the dimension of the geometry and scoring grids have been performed for a representative class of patient cases in order to provide recommendations on the simulation settings, showing that recommendations derived from the experience in proton therapy cannot be directly translated to the case of carbon ion beams. The MC results with the optimized settings have been compared to the calculations of the analytical treatment planning system (TPS), showing that regardless of the consistency of the two systems (in terms of beam model in water and range calculation in different materials) relevant differences can be found in dosimetric quantities and range, especially in the case of heterogeneous and deep seated treatment sites depending on the ion beam species and energies, homogeneity of the traversed tissue and size of the treated volume. The analysis of typical TPS speed-up approximations highlighted effects which deserve accurate treatment, in contrast to adequate beam model simplifications for scanned ion beam therapy. In terms of biological dose calculations, the investigation of the mixed field components in realistic anatomical situations confirmed the findings of previous groups so far reported only in

  19. Induction of cancer cell death by proton beam in tumor hypoxic region

    International Nuclear Information System (INIS)

    Lee, Y. M.; Hur, T. R.; Lee, K. B.; Jeong, M. H.; Park, J. W.

    2007-04-01

    Proton beam induced apoptosis significantly in Lewis lung carcinoma cells and hepatoma HepG2 cells in a dose- and time-dependent manner, but slightly in leukemia Molt-4 cells. Relative biological effectiveness (RBE) values for death rate relative to gamma ray were ranged from 1.3 to 2.1 in LLC or HepG2 but 0.7 in Molt-4 cells at 72h after irradiation. The typical apoptosis was observed by nuclear DNA staining with DAPI. By FACS analysis after stained with PI, sub-G1 cell fraction was significantly increased but G2/M phase was not altered by proton beam irradiation measured at 24 h after irradiation. Proton beam-irradiated tumor cells induced cleavage of PARP-1 and procaspases (-3 and -9) and increased the level of p53 and p21. decreased pro-lamin B. Acitivity of caspases was significantly increased after proton beam irradiation. Furthermore, ROS were significantly increased and N-acetyl cystein (NAC) pretreatment restored the apoptotic cell death induced in proton beam-irradiated cells. In conclusion, single treatment of low energy proton beam with SOBP induced apoptosis of solid tumor cells via increased ROS, active caspase -3,-9 and p53, p2

  20. Induction of cancer cell death by proton beam in tumor hypoxic region

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Y. M.; Hur, T. R.; Lee, K. B.; Jeong, M. H.; Park, J. W. [Kyungbook National Univ., Daegu (Korea, Republic of)

    2007-04-15

    Proton beam induced apoptosis significantly in Lewis lung carcinoma cells and hepatoma HepG2 cells in a dose- and time-dependent manner, but slightly in leukemia Molt-4 cells. Relative biological effectiveness (RBE) values for death rate relative to gamma ray were ranged from 1.3 to 2.1 in LLC or HepG2 but 0.7 in Molt-4 cells at 72h after irradiation. The typical apoptosis was observed by nuclear DNA staining with DAPI. By FACS analysis after stained with PI, sub-G1 cell fraction was significantly increased but G2/M phase was not altered by proton beam irradiation measured at 24 h after irradiation. Proton beam-irradiated tumor cells induced cleavage of PARP-1 and procaspases (-3 and -9) and increased the level of p53 and p21. decreased pro-lamin B. Acitivity of caspases was significantly increased after proton beam irradiation. Furthermore, ROS were significantly increased and N-acetyl cystein (NAC) pretreatment restored the apoptotic cell death induced in proton beam-irradiated cells. In conclusion, single treatment of low energy proton beam with SOBP induced apoptosis of solid tumor cells via increased ROS, active caspase -3,-9 and p53, p2.

  1. Biophysical characterization of a relativistic proton beam for image-guided radiosurgery.

    Science.gov (United States)

    Yu, Zhan; Vanstalle, Marie; La Tessa, Chiara; Jiang, Guo-Liang; Durante, Marco

    2012-07-01

    We measured the physical and radiobiological characteristics of 1 GeV protons for possible applications in stereotactic radiosurgery (image-guided plateau-proton radiosurgery). A proton beam was accelerated at 1 GeV at the Brookhaven National Laboratory (Upton, NY) and a target in polymethyl methacrylate (PMMA) was used. Clonogenic survival was measured after exposures to 1-10 Gy in three mammalian cell lines. Measurements and simulations demonstrate that the lateral scattering of the beam is very small. The lateral dose profile was measured with or without the 20-cm plastic target, showing no significant differences up to 2 cm from the axis A large number of secondary swift protons are produced in the target and this leads to an increase of approximately 40% in the measured dose on the beam axis at 20 cm depth. The relative biological effectiveness at 10% survival level ranged between 1.0 and 1.2 on the beam axis, and was slightly higher off-axis. The very low lateral scattering of relativistic protons and the possibility of using online proton radiography during the treatment make them attractive for image-guided plateau (non-Bragg peak) stereotactic radiosurgery.

  2. Biophysical characterization of a relativistic proton beam for image-guided radiosurgery

    International Nuclear Information System (INIS)

    Yu, Z.; Vanstalle, M.; La Tessa, C.; Durante, M.; Jiang Guoliang

    2012-01-01

    We measured the physical and radiobiological characteristics of 1 GeV protons for possible applications in stereotactic radiosurgery (image-guided plateau-proton radiosurgery). A proton beam was accelerated at 1 GeV at the Brookhaven National Laboratory (Upton, NY) and a target in polymethyl methacrylate (PMMA) was used. Clonogenic survival was measured after exposures to 1-10 Gy in three mammalian cell lines. Measurements and simulations demonstrate that the lateral scattering of the beam is very small. The lateral dose profile was measured with or without the 20-cm plastic target, showing no significant differences up to 2 cm from the axis A large number of secondary swift protons are produced in the target and this leads to an increase of approximately 40% in the measured dose on the beam axis at 20 cm depth. The relative biological effectiveness at 10% survival level ranged between 1.0 and 1.2 on the beam axis, and was slightly higher off-axis. The very low lateral scattering of relativistic protons and the possibility of using online proton radiography during the treatment make them attractive for image-guided plateau (non-Bragg peak) stereotactic radiosurgery. (author)

  3. Modified conductivity of polymer materials with proton beam

    International Nuclear Information System (INIS)

    Matsumoto, Shinji; Seki, Miharu; Shima, Kunihiro; Ishihara, Toyoyuki

    2001-01-01

    Ionic conductivity of polymer materials is of increasing interest in many scientific fields. Industrial applications seem to be promising. In the present investigation, we used proton bombardment to modify the characteristic properties of polymers, especially for improvement in conductivity and hardening gel polymers. Particle beam bombardment is known to produce many scissions by particle passages and new bonds by bridge connection. These effects may modify various properties in many ways. We examined the modification of conductivity in solid polymers composed of polyethylene oxide and polyurethane and the surface appearance of gel polymers with bombardment by a proton beam using the accelerator facility of Tsukuba University. The results indicated proton bombardment induced conductivity changes in various ways according to particle range and polymer properties. (author)

  4. Proton gradients and proton-dependent transport processes in the chloroplast

    Directory of Open Access Journals (Sweden)

    Ricarda eHöhner

    2016-02-01

    Full Text Available Proton gradients are fundamental to chloroplast function. Across thylakoid membranes, the light induced proton gradient is essential for ATP synthesis. As a result of proton pumping into the thylakoid lumen, an alkaline stromal pH develops, which is required for full activation of pH-dependent Calvin Benson cycle enzymes. This implies that a pH gradient between the cytosol (pH 7 and the stroma (pH 8 is established upon illumination. To maintain this pH gradient chloroplasts actively extrude protons. More than 30 years ago it was already established that these proton fluxes are electrically counterbalanced by Mg2+, K+ or Cl- fluxes, but only recently the first transport systems that regulate the pH gradient were identified. Notably several (Na+,K+/H+ antiporter systems where identified, that play a role in pH gradient regulation, ion homeostasis, osmoregulation, or coupling of secondary active transport. The established pH gradients are important to drive uptake of essential ions and solutes, but not many transporters involved have been identified to date. In this mini review we summarize the current status in the field and the open questions that need to be addressed in order to understand how pH gradients are maintained, how this is interconnected with other transport processes and what this means for chloroplast function.

  5. Mutant breeding of ornamental trees for creating variations with high value using Proton Beam

    International Nuclear Information System (INIS)

    Kwon, H. J.; Lim, J. H.; Woo, S. M.; Hwang, M. J.; Pyo, S. H.; Woo, J. S.

    2009-04-01

    It is necessary to induce the improved strains of ornamental plants with more disease-resistant and useful for landscape or phytoremediation. Mutation breeding has played an important role in crop improvement, and more than 2,000 mutant cultivars have been released. For the induction of mutation, gamma rays and X-rays are widely used as a mutagen. Proton beam had higher energy than -ray and worked with localized strength, so that proton-beam radiation could be valuable tool to induce useful strains of ornamental plants. Proton ion beam irradiation was used to induce a useful mutant in rice, chrysanthemum, carnation, and so on in Japan. Also, proton ion beam was used to select a useful host strain, in polyhydroxybutyrate (PHB), a member of biodegradable plastic, could be overproduced in Korea. Therefore, we surmise that the effects of proton beam is different from those of gamma rays and X-rays, and we expect proton beam to be a new mutagen. This research was conducted to investigate the proton-beam radiation sensitivity and seed germination rate of the various ornamental plants like as Albizia julibrissin, Ficus religiosa, Rhus chinensis, Sorbaria sorbilfolia and Spiraea chinensis, to survey the quantitative characteristics of proton beam induced strains. To induce the variants of ornamental plants, seeds were irradiated at the dose of 0∼2kGy of proton beam at room temperature. Proton beam energy level was 45 MeV and was irradiated at dose of 0∼2kGy by MC-50 Cyclotron. After irradiation, to assess the effects of proton beam on radiation sensitivity and morphological changes of the plants and the seed germination rate were analysed. By the proton beam radiation, the germination rate decreased at the higher dose. The other hand, the germination rate of Rhus chinensis increased the dose higher, so that it need to investigate the germination rate over 2kGy radiation. The effects of mutation induction by proton beam irradiation on seeds in Lagerstroemia indica were

  6. Mutant breeding of ornamental trees for creating variations with high value using Proton Beam

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, H. J.; Lim, J. H.; Woo, S. M.; Hwang, M. J.; Pyo, S. H.; Woo, J. S. [Phygen Co., Daejeon (Korea, Republic of)

    2009-04-15

    It is necessary to induce the improved strains of ornamental plants with more disease-resistant and useful for landscape or phytoremediation. Mutation breeding has played an important role in crop improvement, and more than 2,000 mutant cultivars have been released. For the induction of mutation, gamma rays and X-rays are widely used as a mutagen. Proton beam had higher energy than -ray and worked with localized strength, so that proton-beam radiation could be valuable tool to induce useful strains of ornamental plants. Proton ion beam irradiation was used to induce a useful mutant in rice, chrysanthemum, carnation, and so on in Japan. Also, proton ion beam was used to select a useful host strain, in polyhydroxybutyrate (PHB), a member of biodegradable plastic, could be overproduced in Korea. Therefore, we surmise that the effects of proton beam is different from those of gamma rays and X-rays, and we expect proton beam to be a new mutagen. This research was conducted to investigate the proton-beam radiation sensitivity and seed germination rate of the various ornamental plants like as Albizia julibrissin, Ficus religiosa, Rhus chinensis, Sorbaria sorbilfolia and Spiraea chinensis, to survey the quantitative characteristics of proton beam induced strains. To induce the variants of ornamental plants, seeds were irradiated at the dose of 0{approx}2kGy of proton beam at room temperature. Proton beam energy level was 45 MeV and was irradiated at dose of 0{approx}2kGy by MC-50 Cyclotron. After irradiation, to assess the effects of proton beam on radiation sensitivity and morphological changes of the plants and the seed germination rate were analysed. By the proton beam radiation, the germination rate decreased at the higher dose. The other hand, the germination rate of Rhus chinensis increased the dose higher, so that it need to investigate the germination rate over 2kGy radiation. The effects of mutation induction by proton beam irradiation on seeds in Lagerstroemia

  7. Ablative acceleration of thin foil targets by intense proton beams

    International Nuclear Information System (INIS)

    Miyamoto, S.; Ozaki, T.; Imasaki, K.; Higaki, S.; Nakai, S.

    1981-01-01

    A focused proton beam of up to 2 x 10 10 w/cm 2 was obtained using pinch-reflex ion diode connected to Reiden IV generator. Experiments of beam target interaction have been done using thin foil targets. In this power range the interaction was explained classically. The experimental dependence of ablation pressure on proton beam intensity was obtained as P sub(a) = 3 x 10 -3 I sup(0.7) bar (I in w/cm 2 ). (author)

  8. A polarimeter for GeV protons of recirculating synchrotron beams

    CERN Document Server

    Bauer, F

    1999-01-01

    A polarimeter for use in recirculating beams of proton synchrotrons with energies from 300 MeV up to several GeV has been developed. The polarimetry is based on the asymmetry measurement of elastic p->p scattering on an internal CH sub 2 fiber target. The forward going protons are detected with two scintillator systems on either side of the beam pipe close to the angle THETA sub f of maximum analyzing power A sub N. Each one operates in coincidence with a broad (DELTA THETA sub b =21.4 deg. ), segmented detector system for the recoil proton of kinematically varying direction THETA sub b; this position resolution is also used for a concurrent measurement of the p->C and nonelastic p->p background. The CH sub 2 fiber can be replaced by a carbon fiber for detailed background studies; 'false' asymmetries are accounted for with a rotation of the polarimeter around the beam axis. Polarimetry has been performed in the internal beam of the Cooler Synchrotron COSY at fixed energies as well as during proton acceleratio...

  9. Proton beam induced dynamics of tungsten granules

    Science.gov (United States)

    Caretta, O.; Loveridge, P.; O'Dell, J.; Davenne, T.; Fitton, M.; Atherton, A.; Densham, C.; Charitonidis, N.; Efthymiopoulos, I.; Fabich, A.; Guinchard, M.; Lacny, L. J.; Lindstrom, B.

    2018-03-01

    This paper reports the results from single-pulse experiments of a 440 GeV /c proton beam interacting with granular tungsten samples in both vacuum and helium environments. Remote high-speed photography and laser Doppler vibrometry were used to observe the effect of the beam on the sample grains. The majority of the results were derived from a trough containing ˜45 μ m diameter spheres (not compacted) reset between experiments to maintain the same initial conditions. Experiments were also carried out on other open and contained samples for the purposes of comparison both with the 45 μ m grain results and with a previous experiment carried out with sub-250 μ m mixed crystalline tungsten powder in helium [Phys. Rev. ST Accel. Beams 17, 101005 (2014), 10.1103/PhysRevSTAB.17.101005]. The experiments demonstrate that a greater dynamic response is produced in a vacuum than in a helium environment and in smaller grains compared with larger grains. The examination of the dynamics of the grains after a beam impact leads to the hypothesis that the grain response is primarily the result of a charge interaction of the proton beam with the granular medium.

  10. Beam dynamics simulation of a double pass proton linear accelerator

    Directory of Open Access Journals (Sweden)

    Kilean Hwang

    2017-04-01

    Full Text Available A recirculating superconducting linear accelerator with the advantage of both straight and circular accelerator has been demonstrated with relativistic electron beams. The acceleration concept of a recirculating proton beam was recently proposed [J. Qiang, Nucl. Instrum. Methods Phys. Res., Sect. A 795, 77 (2015NIMAER0168-900210.1016/j.nima.2015.05.056] and is currently under study. In order to further support the concept, the beam dynamics study on a recirculating proton linear accelerator has to be carried out. In this paper, we study the feasibility of a two-pass recirculating proton linear accelerator through the direct numerical beam dynamics design optimization and the start-to-end simulation. This study shows that the two-pass simultaneous focusing without particle losses is attainable including fully 3D space-charge effects through the entire accelerator system.

  11. Proton-beam writing channel based on an electrostatic accelerator

    Science.gov (United States)

    Lapin, A. S.; Rebrov, V. A.; Kolin'ko, S. V.; Salivon, V. F.; Ponomarev, A. G.

    2016-09-01

    We have described the structure of the proton-beam writing channel as a continuation of a nuclear scanning microprobe channel. The problem of the accuracy of positioning a probe by constructing a new high-frequency electrostatic scanning system has been solved. Special attention has been paid to designing the probe-forming system and its various configurations have been considered. The probe-forming system that best corresponds to the conditions of the lithographic process has been found based on solving the problem of optimizing proton beam formation. A system for controlling beam scanning using multifunctional module of integrated programmable logic systems has been developed.

  12. Proton beam radiotherapy of choroidal melanoma: The Liverpool-Clatterbridge experience

    International Nuclear Information System (INIS)

    Damato, Bertil; Kacperek, Andrzej; Chopra, Mona; Campbell, Ian R.; Errington, R. Douglas

    2005-01-01

    Purpose To report on outcomes after proton beam radiotherapy of choroidal melanoma using a 62-MeV cyclotron in patients considered unsuitable for other forms of conservative therapy. Methods and Materials A total of 349 patients with choroidal melanoma referred to the Liverpool Ocular Oncology Centre underwent proton beam radiotherapy at Clatterbridge Centre for Oncology (CCO) between January 1993 and December 2003. Four daily fractions of proton beam radiotherapy were delivered, with a total dose of 53.1 proton Gy, and with lateral and distal safety margins of 2.5 mm. Outcomes measured were local tumor recurrence; ocular conservation; vision; and metastatic death according to age, gender, eye, visual acuity, location of anterior and posterior tumor margins, quadrant, longest basal tumor dimension, tumor height, extraocular extension, and retinal invasion. Results The 5-year actuarial rates were 3.5% for local tumor recurrence, 9.4% for enucleation, 79.1% for conservation of vision of counting fingers or better, 61.1% for conservation of vision of 20/200 or better, 44.8% for conservation of vision of 20/40 or better, and 10.0% for death from metastasis. Conclusion Proton beam radiotherapy with a 62 MeV cyclotron achieves high rates of local tumor control and ocular conservation, with visual outcome depending on tumor size and location

  13. Proton beam generation of whistler waves in the earth's foreshock

    Science.gov (United States)

    Wong, H. K.; Goldstein, M. L.

    1987-01-01

    It is shown that proton beams, often observed upstream of the earth's bow shock and associated with the generation of low-frequency hydromagnetic fluctuations, are also capable of generating whistler waves. The waves can be excited by an instability driven by two-temperature streaming Maxwellian proton distributions which have T (perpendicular)/T(parallel) much greater than 1. It can also be excited by gyrating proton beam distributions. These distributions generate whistler waves with frequencies ranging from 10 to 100 times the proton cyclotron frequency (in the solar wind reference frame) and provide another mechanism for generating the '1-Hz' waves often seen in the earth's foreshock.

  14. Proton beam generation of whistler waves in the Earth's foreshock

    International Nuclear Information System (INIS)

    Wong, H.K.; Goldstein, M.L.

    1987-01-01

    We show that proton beams, often observed upstream of the Earth's bow shock and associated with the generation of low-frequency hydromagnetic fluctuations, are also capable of generating whistler waves. The waves can be excited by an instability driven by two-temperature streaming Maxwellian proton distributions which have T/sub perpendicular//T/sub parallel/>>1. It can also be excited by gyrating proton beam distributions. These distributions generate whistler waves with frequencies ranging from 10 to 100 times the proton cyclotron frequency (in the solar wind reference frame) and provide another mechanism for generating the ''1-Hz'' waves often seen in the Earth's foreshock

  15. Structural design study of a proton beam window for a 1-MW spallation neutron source

    CERN Document Server

    Teraoku, T; Ishikura, S; Kaminaga, M; Maekawa, F; Meigo, S I; Terada, A

    2003-01-01

    A 1-MW spallation neutron source aiming at materials and life science researches will be constructed under the JAERI-KEK High-intensity Proton Accelerator Project (J-PARC). A proton beam passes through a proton beam window, and be injected into a target of the neutron source. The proton beam window functions as a boundary wall between a high vacuum area in the proton beam line and a helium atmosphere at about atmospheric pressure in a helium vessel which contains the target and moderators. The proton beam window is cooled by light water because high heat-density is generated in the window material by interactions with the proton beam. Then, uniformity of the water flow is requested at the window to suppress a hot-spot that causes excessive thermal stress and cooling water boiling. Also, the window has to be strong enough in its structure for inner stress due to water pressure and thermal stress due to heat generation. In this report, we propose two types of proton beam windows; one flat-type that is easy to m...

  16. Proton beam modification of lead white pigments

    International Nuclear Information System (INIS)

    Beck, L.; Gutiérrez, P.C.; Miserque, F.; Thomé, L.

    2013-01-01

    Pigments and paint materials are known to be sensitive to particle irradiation. Occasionally, the analysis of paintings by PIXE can induce a slight or dark stain depending on the experimental conditions (beam current, dose, particle energy). In order to understand this discoloration, we have irradiated various types of art white pigments – lead white (hydrocerussite and basic lead sulfate), gypsum, calcite, zinc oxide and titanium oxide – with an external 3 MeV proton micro-beam commonly used for PIXE experiments. We have observed various sensitivities depending on the pigment. No visible change occurs for calcite and titanium oxide, whereas lead white pigments are very sensitive. For the majority of the studied compounds, the discoloration is proportional to the beam current and charge. The damage induced by proton beam irradiation in lead white pigments was studied by micro-Raman and XPS spectroscopies. Structural modifications and dehydration were detected. Damage recovery was investigated by thermal treatment and UV-light irradiation. The discoloration disappeared after one week of UV illumination, showing that PIXE experiments could be safely undertaken for pigments and paintings

  17. A free-jet Hg target operating in a high magnetic field intersecting a high-power proton beam

    Science.gov (United States)

    Van Graves; Spampinato, Philip; Gabriel, Tony; Kirk, Harold; Simos, Nicholas; Tsang, Thomas; McDonald, Kirk; Peter Titus; Fabich, Adrian; Haseroth, Helmut; Lettry, Jacques

    2006-06-01

    A proof-of-principal experiment to investigate the interaction of a proton beam, high magnetic field, and high- Z target is planned to take place at CERN in early 2007. This experiment is part of the Muon Collider Collaboration, with participants from Brookhaven National Laboratory, Princeton University, Massachusetts Institute Of Technology, European Organization for Nuclear Research-CERN, Rutherford Appleton Laboratory, and Oak Ridge National Laboratory. An unconstrained mercury jet target system that interacts with a high power (1 MW) proton beam in a high magnetic field (15 T) is being designed. The Hg jet diameter is 1-cm with a velocity up to 20 m/s. A laser optical diagnostic system will be incorporated into the target design to permit observation of the dispersal of the jet resulting from interaction with a 24 GeV proton beam with up to 20×10 12 ppp. The target system includes instruments for sensing mercury vapor, temperature, flow rate, and sump tank level, and the means to position the jet relative to the magnetic axis of a solenoid and the proton beam. The design considerations for the system include all issues dealing with safely handling approximately 23 l of Hg, transporting the target system and the mercury to CERN, decommissioning the experiment, and returning the mildly activated equipment and Hg to the US.

  18. The generation of absorbed dose profiles of proton beam in water using Geant4 code

    International Nuclear Information System (INIS)

    Christovao, Marilia T.; Campos, Tarcisio Passos R. de

    2007-01-01

    The present article approaches simulations on the proton beam radiation therapy, using an application based on the code GEANT4, with Open GL as a visualization drive and JAS3 (Java Analysis Studio) analysis data tools systems, implementing the AIDA interfaces. The proton radiotherapy is adapted to treat cancer or other benign tumors that are close to sensitive structures, since it allows precise irradiation of the target with high doses, while the health tissues adjacent to vital organs and tissues are preserved, due to physical property of dose profile. GEANT4 is a toolkit for simulating the transport of particles through matter, in complex geometries. Taking advantage of the object-oriented project features, the user can adapt or extend the tool in all domain, due to the flexibility of the code, providing a subroutine's group for materials definition, geometries and particles properties in agreement with the user's needs to generate the Monte Carlo simulation. In this paper, the parameters of beam line used in the simulation possess adjustment elements, such as: the range shifter, composition and dimension; the beam line, energy, intensity, length, according with physic processes applied. The simulation result is the depth dose profiles on water, dependent on the various incident beam energy. Starting from those profiles, one can define appropriate conditions for proton radiotherapy in ocular region. (author)

  19. Production of high-brightness continuous wave proton beams with very high proton fractions (abstract)a

    International Nuclear Information System (INIS)

    Spence, D.; McMichael, G.; Lykke, K.R.; Schneider, J.D.; Sherman, J.; Stevens, R. Jr.; Hodgkins, D.

    1996-01-01

    This article demonstrates a new technique to significantly enhance the proton fraction of an ion beam extracted from a plasma ion source. We employ a magnetically confined microwave driven source, though the technique is not source specific and can probably be applied equally effectively to other plasma sources such as Penning and multicusp types. Specifically, we dope the plasma with about 1% H 2 O, which increases the proton fraction of a 45 keV 45 mA beam from 75% to 90% with 375 W 2.45 GHz power to the source and from 84% to 92% for 500 W when the source is operated under nonresonant conditions. Much of the remaining fraction of the beam comprises a heavy mass ion we believe to be N + impurity ions resulting from the conditions under which the experiments were performed. If so, this impurity can easily be removed and much higher proton fractions could be expected. Preliminary measurements show the additive has no adverse effect on the emittance of the extracted beam, and source stability is greatly improved

  20. Direct measurement of the energy spectrum of an intense proton beam

    International Nuclear Information System (INIS)

    Leeper, R.J.; Lee, J.R.; Kissel, L.; Johnson, D.J.; Stygar, W.A.; Hebron, D.E.; Roose, L.D.

    1983-01-01

    A time-resolved magnetic spectrometer has been used to measure the energy spectrum of an intense (0.5 TW/cm 2 ) proton beam. A thin (2400 A) gold foil placed at the focus of an ion diode Rutherford scattered protons by 90 0 into the spectrometer, reducing the beam intensity to a level suitable for magnetic analysis. The scattered beam was collimated by two 1 mm diameter apertures separated by 12.3 cm. The collimated protons were deflected in a 12.7 cm diameter, 6.65 Kg samarium-cobalt permanent magnet. The deflected protons were recorded simultaneously on CR-39 and eight 1 mm 2 by 35 μm thick PIN diodes. A Monte Carlo computer code was used to calculate the sensitivity and resolution of the spectrometer. Data taken on Proto-I show a 150 keV to 250 keV wide proton energy spectrum at each instant in time

  1. Repeated proton beam therapy for hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Hashimoto, Takayuki; Tokuuye, Koichi; Fukumitsu, Nobuyoshi; Igaki, Hiroshi; Hata, Masaharu; Kagei, Kenji; Sugahara, Shinji; Ohara, Kiyoshi; Matsuzaki, Yasushi; Akine, Yasuyuki

    2006-01-01

    Purpose: To retrospectively evaluate the safety and effectiveness of repeated proton beam therapy for newly developed or recurrent hepatocellular carcinoma (HCC). Methods and Materials: From June 1989 through July 2000, 225 patients with HCC underwent their first course of proton beam therapy at University of Tsukuba. Of them, 27 with 68 lesions who had undergone two or more courses were retrospectively reviewed in this study. Median interval between the first and second course was 24.5 months (range 3.3-79.8 months). Median total dose of 72 Gy in 16 fractions and 66 Gy in 16 fractions were given for the first course and the rest of the courses, respectively. Results: The 5-year survival rate and median survival period from the beginning of the first course for the 27 patients were 55.6% and 62.2 months, respectively. Five-year local control rate for the 68 lesions was 87.8%. Of the patients, 1 with Child-Pugh class B and another with class C before the last course suffered from acute hepatic failure. Conclusions: Repeated proton beam therapy for HCC is safe when the patient has a target in the peripheral region of the liver and liver function is Child-Pugh class A

  2. Comparison of short-lived medical isotopes activation by laser thin target induced protons and conventional cyclotron proton beams

    Science.gov (United States)

    Murray, Joseph; Dudnikova, Galina; Liu, Tung-Chang; Papadopoulos, Dennis; Sagdeev, Roald; Su, J. J.; UMD MicroPET Team

    2014-10-01

    Production diagnostic or therapeutic nuclear medicines are either by nuclear reactors or by ion accelerators. In general, diagnostic nuclear radioisotopes have a very short half-life varying from tens of minutes for PET tracers and few hours for SPECT tracers. Thus supplies of PET and SPECT radiotracers are limited by regional production facilities. For example 18F-fluorodeoxyglucose (FDG) is the most desired tracer for positron emission tomography because its 110 minutes half-life is sufficient long for transport from production facilities to nearby users. From nuclear activation to completing image taking must be done within 4 hours. Decentralized production of diagnostic radioisotopes will be idea to make high specific activity radiotracers available to researches and clinicians. 11 C, 13 N, 15 O and 18 F can be produced in the energy range from 10-20 MeV by protons. Protons of energies up to tens of MeV generated by intense laser interacting with hydrogen containing targets have been demonstrated by many groups in the past decade. We use 2D PIC code for proton acceleration, Geant4 Monte Carlo code for nuclei activation to compare the yields and specific activities of short-lived isotopes produced by cyclotron proton beams and laser driven protons.

  3. Rhabdomyosarcoma of the trachea: first reported case treated with proton beam therapy.

    Science.gov (United States)

    Exley, R; Bernstein, J M; Brennan, B; Rothera, M P

    2012-09-01

    We report a case of rhabdomyosarcoma of the trachea in a 14-month-old child, and we present the first reported use of proton beam therapy for this tumour. A 14-month-old girl presented acutely with a seven-day history of biphasic stridor. Emergency endoscopic debulking of a posterior tracheal mass was undertaken. Histological examination revealed an embryonal rhabdomyosarcoma with anaplasia. Multimodality therapy with surgery and chemotherapy was administered in the UK, and proton beam therapy in the USA. Only three cases of rhabdomyosarcoma of the trachea have previously been reported in the world literature. This is the first reported case of treatment of this tumour with proton beam therapy. Compared with conventional radiotherapy, proton beam therapy may confer improved long-term outcome in children, with benefits including reduced irradiation of the spinal cord.

  4. Advances in complexity of beam halo-chaos and its control methods for beam transport networks

    International Nuclear Information System (INIS)

    Fang Jinqing

    2004-11-01

    The complexity theory of beam halo-chaos in beam transport networks and its control methods for a new subject of high-tech field is discussed. It is pointed that in recent years, there has been growing interest in proton beams of high power linear accelerator due to its attractive features in possible breakthrough applications in national defense and industry. In particular, high-current accelerator driven clean activity nuclear power systems for various applications as energy resources has been one of the most focusing issues in the current research, because it provides a safer, cleaner and cheaper nuclear energy resource. However, halo-chaos in high-current beam transport networks become a key concerned issue because it can generate excessive radioactivity therefore significantly limits its applications. It is very important to study the complexity properties of beam halo-chaos and to understand the basic physical mechanisms for halo chaos formation as well as to develop effective control methods for its suppression. These are very challenging subjects for the current research. The main research advances in the subjects, including experimental investigation and the oretical research, especially some very efficient control methods developed through many years of efforts of authors are reviewed and summarized. Finally, some research outlooks are given. (author)

  5. Principles and practice of proton beam therapy

    CERN Document Server

    Das, Indra J

    2015-01-01

    Commissioned by The American Association of Physicists in Medicine (AAPM) for their June 2015 Summer School, this is the first AAPM monograph printed in full color. Proton therapy has been used in radiation therapy for over 70 years, but within the last decade its use in clinics has grown exponentially. This book fills in the proton therapy gap by focusing on the physics of proton therapy, including beam production, proton interactions, biology, dosimetry, treatment planning, quality assurance, commissioning, motion management, and uncertainties. Chapters are written by the world's leading medical physicists who work at the pioneering proton treatment centers around the globe. They share their understandings after years of experience treating thousands of patients. Case studies involving specific cancer treatments show that there is some art to proton therapy as well as state-of-the-art science. Even though the focus lies on proton therapy, the content provided is also valuable to heavy charged particle th...

  6. Clinical results of proton beam therapy for skull base chordoma

    International Nuclear Information System (INIS)

    Igaki, Hiroshi; Tokuuye, Koichi; Okumura, Toshiyuki; Sugahara, Shinji; Kagei, Kenji; Hata, Masaharu; Ohara, Kiyoshi; Hashimoto, Takayuki; Tsuboi, Koji; Takano, Shingo; Matsumura, Akira; Akine, Yasuyuki

    2004-01-01

    Purpose: To evaluate clinical results of proton beam therapy for patients with skull base chordoma. Methods and materials: Thirteen patients with skull base chordoma who were treated with proton beams with or without X-rays at the University of Tsukuba between 1989 and 2000 were retrospectively reviewed. A median total tumor dose of 72.0 Gy (range, 63.0-95.0 Gy) was delivered. The patients were followed for a median period of 69.3 months (range, 14.6-123.4 months). Results: The 5-year local control rate was 46.0%. Cause-specific, overall, and disease-free survival rates at 5 years were 72.2%, 66.7%, and 42.2%, respectively. The local control rate was higher, without statistical significance, for those with preoperative tumors <30 mL. Partial or subtotal tumor removal did not yield better local control rates than for patients who underwent biopsy only as the latest surgery. Conclusion: Proton beam therapy is effective for patients with skull base chordoma, especially for those with small tumors. For a patient with a tumor of <30 mL with no prior treatment, biopsy without tumor removal seems to be appropriate before proton beam therapy

  7. High current beam transport with multiple beam arrays

    International Nuclear Information System (INIS)

    Kim, C.H.

    1985-05-01

    Highlights of recent experimental and theoretical research progress on the high current beam transport of single and multiple beams by the Heavy Ion Fusion Accelerator Research (HIFAR) group at the Lawrence Berkeley Laboratory (LBL) are presented. In the single beam transport experiment (SBTE), stability boundaries and the emittance growth of a space charge dominated beam in a long quadrupole transport channel were measured and compared with theory and computer simulations. Also, a multiple beam ion induction linac (MBE-4) is being constructed at LBL which will permit study of multiple beam transport arrays, and acceleration and bunch length compression of individually focused beamlets. Various design considerations of MBE-4 regarding scaling laws, nonlinear effects, misalignments, and transverse and longitudinal space charge effects are summarized. Some aspects of longitudinal beam dynamics including schemes to generate the accelerating voltage waveforms and to amplify beam current are also discussed

  8. Proton beam induced dynamics of tungsten granules

    Directory of Open Access Journals (Sweden)

    O. Caretta

    2018-03-01

    Full Text Available This paper reports the results from single-pulse experiments of a 440  GeV/c proton beam interacting with granular tungsten samples in both vacuum and helium environments. Remote high-speed photography and laser Doppler vibrometry were used to observe the effect of the beam on the sample grains. The majority of the results were derived from a trough containing ∼45  μm diameter spheres (not compacted reset between experiments to maintain the same initial conditions. Experiments were also carried out on other open and contained samples for the purposes of comparison both with the 45  μm grain results and with a previous experiment carried out with sub-250  μm mixed crystalline tungsten powder in helium [Phys. Rev. ST Accel. Beams 17, 101005 (2014PRABFM1098-440210.1103/PhysRevSTAB.17.101005]. The experiments demonstrate that a greater dynamic response is produced in a vacuum than in a helium environment and in smaller grains compared with larger grains. The examination of the dynamics of the grains after a beam impact leads to the hypothesis that the grain response is primarily the result of a charge interaction of the proton beam with the granular medium.

  9. Proton external beam in the TANDAR Accelerator; Haz externo de protones en el acelerador TANDAR

    Energy Technology Data Exchange (ETDEWEB)

    Rey, R; Schuff, J A; Perez de la Hoz, A.; Debray, M E; Hojman, D; Kreiner, A J; Kesque, J M; Saint-Martin, G; Oppezzo, O; Bernaola, O A; Molinari, B L; Duran, H A; Policastro, L; Palmieri, M; Ibanez, J; Stoliar, P; Mazal, A; Caraballo, M E; Burlon, A; Cardona, M A; Vazquez, M E; Salfity, M F; Ozafran, M J; Naab, F; Levinton, G; Davidson, M; Buhler, M [Departamento de Fisica, Comision Nacional de Energia Atomica, Av. Gral. Paz 1499, C.P. 1650 San Martin, Buenos Aires (Argentina)

    1999-12-31

    An external proton beam has been obtained in the TANDAR accelerator with radiological and biomedical purposes. The protons have excellent physical properties for their use in radiotherapy allowing a very good accuracy in the dose spatial distribution inside the tissue so in the side direction as in depth owing to the presence of Bragg curve. The advantage of the accuracy in the dose localization with proton therapy is good documented (M. Wagner, Med. Phys. 9, 749 (1982); M. Goitein and F. Chen, Med. Phys. 10, 831 (1983); M.R. Raju, Rad. Res. 145, 391 (1996)). It was obtained external proton beams with energies between 15-25 MeV, currents between 2-10 p A and a uniform transversal sections of 40 mm{sup 2} approximately. It was realized dosimetric evaluations with CR39 and Makrofol foliation. The irradiations over biological material contained experiences In vivo with laboratory animals, cellular and bacterial crops. It was fixed the optimal conditions of position and immobilization of the Wistar rats breeding for the In vivo studies. It was chosen dilutions and sowing techniques adequate for the exposition at the cellular and bacterial crops beam. (Author)

  10. Proton external beam in the TANDAR Accelerator; Haz externo de protones en el acelerador TANDAR

    Energy Technology Data Exchange (ETDEWEB)

    Rey, R.; Schuff, J.A.; Perez de la Hoz, A.; Debray, M.E.; Hojman, D.; Kreiner, A.J.; Kesque, J.M.; Saint-Martin, G.; Oppezzo, O.; Bernaola, O.A.; Molinari, B.L.; Duran, H.A.; Policastro, L.; Palmieri, M.; Ibanez, J.; Stoliar, P.; Mazal, A.; Caraballo, M.E.; Burlon, A.; Cardona, M.A.; Vazquez, M.E.; Salfity, M.F.; Ozafran, M.J.; Naab, F.; Levinton, G.; Davidson, M.; Buhler, M. [Departamento de Fisica, Comision Nacional de Energia Atomica, Av. Gral. Paz 1499, C.P. 1650 San Martin, Buenos Aires (Argentina)

    1998-12-31

    An external proton beam has been obtained in the TANDAR accelerator with radiological and biomedical purposes. The protons have excellent physical properties for their use in radiotherapy allowing a very good accuracy in the dose spatial distribution inside the tissue so in the side direction as in depth owing to the presence of Bragg curve. The advantage of the accuracy in the dose localization with proton therapy is good documented (M. Wagner, Med. Phys. 9, 749 (1982); M. Goitein and F. Chen, Med. Phys. 10, 831 (1983); M.R. Raju, Rad. Res. 145, 391 (1996)). It was obtained external proton beams with energies between 15-25 MeV, currents between 2-10 p A and a uniform transversal sections of 40 mm{sup 2} approximately. It was realized dosimetric evaluations with CR39 and Makrofol foliation. The irradiations over biological material contained experiences In vivo with laboratory animals, cellular and bacterial crops. It was fixed the optimal conditions of position and immobilization of the Wistar rats breeding for the In vivo studies. It was chosen dilutions and sowing techniques adequate for the exposition at the cellular and bacterial crops beam. (Author)

  11. Microdosimetric investigation at the therapeutic proton beam facility of CATANA.

    Science.gov (United States)

    De Nardo, L; Moro, D; Colautti, P; Conte, V; Tornielli, G; Cuttone, G

    2004-01-01

    Proton beams (62 Mev) are used by the Laboratori Nazionali del Sud of the Italian Institute of Nuclear Physics to treat eye melanoma tumours at the therapeutic facility called CATANA. A cylindrical slim tissue-equivalent proportional counter (TEPC) of 2.7 mm external diameter has been used to compare the radiation quality of two spread-out Bragg peaks (SOBP) at the CATANA proton beam.

  12. Microdosimetric investigation at the therapeutic proton beam facility of Catana

    International Nuclear Information System (INIS)

    De Nardo, L.; Moro, D.; Colautti, P.; Conte, V.; Tornielli, G.; Cuttone, G.

    2004-01-01

    Proton beams (62 Mev) are used by the Laboratori Nazionali del Sud of the Italian Inst. of Nuclear Physics to treat eye melanoma tumours at the therapeutic facility called CATANA. A cylindrical slim tissue-equivalent proportional counter (TEPC) of 2.7 mm external diameter has been used to compare the radiation quality of two spread-out Bragg peaks (SOBP) at the CATANA proton beam. (authors)

  13. A high repetition rate transverse beam profile diagnostic for laser-plasma proton sources

    Science.gov (United States)

    Dover, Nicholas; Nishiuchi, Mamiko; Sakaki, Hironao; Kando, Masaki; Nishitani, Keita

    2016-10-01

    The recently upgraded J-KAREN-P laser can provide PW peak power and intensities approaching 1022 Wcm-2 at 0.1 Hz. Scaling of sheath acceleration to such high intensities predicts generation of protons to near 100 MeV, but changes in electron heating mechanisms may affect the emitted proton beam properties, such as divergence and pointing. High repetition rate simultaneous measurement of the transverse proton distribution and energy spectrum are therefore key to understanding and optimising the source. Recently plastic scintillators have been used to measure online proton beam transverse profiles, removing the need for time consuming post-processing. We are therefore developing a scintillator based transverse proton beam profile diagnostic for use in ion acceleration experiments using the J-KAREN-P laser. Differential filtering provides a coarse energy spectrum measurement, and time-gating allows differentiation of protons from other radiation. We will discuss the design and implementation of the diagnostic, as well as proof-of-principle results from initial experiments on the J-KAREN-P system demonstrating the measurement of sheath accelerated proton beams up to 20 MeV.

  14. Supine craniospinal irradiation in pediatric patients by proton pencil beam scanning.

    Science.gov (United States)

    Farace, Paolo; Bizzocchi, Nicola; Righetto, Roberto; Fellin, Francesco; Fracchiolla, Francesco; Lorentini, Stefano; Widesott, Lamberto; Algranati, Carlo; Rombi, Barbara; Vennarini, Sabina; Amichetti, Maurizio; Schwarz, Marco

    2017-04-01

    Proton therapy is the emerging treatment modality for craniospinal irradiation (CSI) in pediatric patients. Herein, special methods adopted for CSI at proton Therapy Center of Trento by pencil beam scanning (PBS) are comprehensively described. Twelve pediatric patients were treated by proton PBS using two/three isocenters. Special methods refer to: (i) patient positioning in supine position on immobilization devices crossed by the beams; (ii) planning field-junctions via the ancillary-beam technique; (iii) achieving lens-sparing by three-beams whole-brain-irradiation; (iv) applying a movable-snout and beam-splitting technique to reduce the lateral penumbra. Patient-specific quality assurance (QA) program was performed using two-dimensional ion chamber array and γ-analysis. Daily kilovoltage alignment was performed. PBS allowed to obtain optimal target coverage (mean D98%>98%) with reduced dose to organs-at-risk. Lens sparing was obtained (mean D1∼730cGyE). Reducing lateral penumbra decreased the dose to the kidneys (mean Dmean4cm (mean γ>95%) than at depths<4cm. The reported methods allowed to effectively perform proton PBS CSI. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. High-Energy Beam Transport system

    International Nuclear Information System (INIS)

    Melson, K.E.; Farrell, J.A.; Liska, D.J.

    1979-01-01

    The High-Energy Beam Transport (HEBT) system for the Fusion Materials Irradiation Test (FMIT) Facility is to be installed at the Hanford Engineering Development Laboratory (HEDL) at Richland, Washington. The linear accelerator must transport a large emittance, high-current, high-power, continuous-duty deuteron beam with a large energy spread either to a lithium target or a beam stop. A periodic quadrupole and bending-magnet system provides the beam transport and focusing on target with small beam aberrations. A special rf cavity distributes the energy in the beam so that the Bragg Peak is distributed within the lithium target. Operation of the rf control system, the Energy Dispersion Cavity (EDC), and the beam transport magnets is tested on the beam stop during accelerator turn-on. Characterizing the beam will require extensions of beam diagnostic techniques and noninterceptive sensors. Provisions are being made in the facility for suspending the transport system from overhead supports using a cluster system to simplify maintenance and alignment techniques

  16. SU-E-T-577: Obliquity Factor and Surface Dose in Proton Beam Therapy

    International Nuclear Information System (INIS)

    Das, I; Andersen, A; Coutinho, L

    2015-01-01

    Purpose: The advantage of lower skin dose in proton beam may be diminished creating radiation related sequalae usually seen with photon and electron beams. This study evaluates the surface dose as a complex function of beam parameters but more importantly the effect of beam angle. Methods: Surface dose in proton beam depends on the beam energy, source to surface distance, the air gap between snout and surface, field size, material thickness in front of surface, atomic number of the medium, beam angle and type of nozzle (ie double scattering, (DS), uniform scanning (US) or pencil beam scanning (PBS). Obliquity factor (OF) is defined as ratio of surface dose in 0° to beam angle Θ. Measurements were made in water phantom at various beam angles using very small microdiamond that has shown favorable beam characteristics for high, medium and low proton energy. Depth dose measurements were performed in the central axis of the beam in each respective gantry angle. Results: It is observed that surface dose is energy dependent but more predominantly on the SOBP. It is found that as SSD increases, surface dose decreases. In general, SSD, and air gap has limited impact in clinical proton range. High energy has higher surface dose and so the beam angle. The OF rises with beam angle. Compared to OF of 1.0 at 0° beam angle, the value is 1.5, 1.6, 1,7 for small, medium and large range respectively for 60 degree angle. Conclusion: It is advised that just like range and SOBP, surface dose should be clearly understood and a method to reduce the surface dose should be employed. Obliquity factor is a critical parameter that should be accounted in proton beam therapy and a perpendicular beam should be used to reduce surface dose

  17. Changes in optical properties of polystyrene thin films by proton beam irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Sung Hyun; Jung, Jin Mook; Choi, Jae Hak [Dept. of of Polymer Science and Engineering, Chungnam National University, Daejeon (Korea, Republic of); Jung, Chan Hee; Hwang, In Tae; Shin, Jun Hwa [Research Division for Industry and Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup(Korea, Republic of)

    2017-06-15

    In this study, changes in optical properties of polystyrene (PS) thin films by proton irradiation were investigated. PS thin films were irradiated with 150 keV proton ions at fluences ranging from 1 × 10{sup 15} to 1 × 10{sup 16} ions cm{sup -2}. The chemical structures and optical properties of proton beam-irradiated PS thin films were investigated by using a FT-IR spectrometer, an UVvis spectrophotometer, a photoluminescence (PL) and a fluorescence microscope. The results of the chemical structure analysis revealed that chemical functional groups, such as OH, C=O, and C=C, were formed in the PS films due to the oxidation and formation of carbon clusters by proton beam irradiation. The PL emission was generated and gradually red-shifted with an increasing fluence due to the higher formation of sp2 carbon clusters by proton beam irradiation. The highest PL intensity was obtained at a fluence of 5×10{sup 15} ions cm{sup -2}. The optical band gap of PS calculated by using a Tauc’s plot decreased with increasing the fluence due to the formation of sp2 carbon clusters by proton beam irradiation.

  18. Poster - 25: Neutron Spectral Measurements around a Scanning Proton Beam

    Energy Technology Data Exchange (ETDEWEB)

    Kildea, John; Enger, Shirin; Maglieri, Robert; Mirzakhanian, Lalageh; Dahlgren, Christina Vallhagen; Dubeau, Jacques; Witharana, Sanjeeva [Medical Physics Unit, McGill University Health Centre, Medical Physics Unit, McGill University, Medical Physics Unit, McGill University, Medical Physics Unit, McGill University, Skandion Clinic, Detec Inc., Gatineau, Quebec, Detec Inc., Gatineau, Quebec (Canada)

    2016-08-15

    We describe the measurements of neutron spectra that we undertook around a scanning proton beam at the Skandion proton therapy clinic in Uppsala, Sweden. Measurements were undertaken using an extended energy range Nested Neutron Spectrometer (NNS, Detec Inc., Gatineau, QC) operated in pulsed and current mode. Spectra were measured as a function of location in the treatment room and for various Bragg peak depths. Our preliminary unfolded data clearly show the direct, evaporation and thermal neutron peaks and we can show the effect on the neutron spectrum of a water phantom in the primary proton beam.

  19. Quasi-monoenergetic proton beam produced by cone-top-end target

    International Nuclear Information System (INIS)

    Yu Jinqing; Jin Xiaolin; Li Bin; Zhou Weimin; Gu Yuqiu

    2012-01-01

    A scheme for generating quasi-monoenergetic proton beam is presented. In this paper, a new cone-top-end target is proposed and investigated by two-dimensional particle-in-cell (2D-PIC) simulation. The simulation results show that this target configuration can guide the hot electrons by the self-generated magnetic field along the profile of the cone-top-end target. The peak magnitude of sheath field at the rear surface of solid target can be enhanced, so the proton energy can be improved. The proton beam with energy spread of 9.9% can be obtained. (authors)

  20. Real-time beam monitoring in scanned proton therapy

    Science.gov (United States)

    Klimpki, G.; Eichin, M.; Bula, C.; Rechsteiner, U.; Psoroulas, S.; Weber, D. C.; Lomax, A.; Meer, D.

    2018-05-01

    When treating cancerous tissues with protons beams, many centers make use of a step-and-shoot irradiation technique, in which the beam is steered to discrete grid points in the tumor volume. For safety reasons, the irradiation is supervised by an independent monitoring system validating cyclically that the correct amount of protons has been delivered to the correct position in the patient. Whenever unacceptable inaccuracies are detected, the irradiation can be interrupted to reinforce a high degree of radiation protection. At the Paul Scherrer Institute, we plan to irradiate tumors continuously. By giving up the idea of discrete grid points, we aim to be faster and more flexible in the irradiation. But the increase in speed and dynamics necessitates a highly responsive monitoring system to guarantee the same level of patient safety as for conventional step-and-shoot irradiations. Hence, we developed and implemented real-time monitoring of the proton beam current and position. As such, we read out diagnostic devices with 100 kHz and compare their signals against safety tolerances in an FPGA. In this paper, we report on necessary software and firmware enhancements of our control system and test their functionality based on three exemplary error scenarios. We demonstrate successful implementation of real-time beam monitoring and, consequently, compliance with international patient safety regulations.

  1. Structural dynamic response of target container against proton beam

    International Nuclear Information System (INIS)

    Kikuchi, Kenji; Ishikura, Syuichi; Futakawa, Masatoshi; Hino, Ryutaro

    1997-01-01

    Stress waves were analyzed for a target container of neutron science research project using a high-intensity proton accelerator that generates high energy and high current proton beam. In the mercury target, the pulsed proton beam generates intense power density in the course of spallation reaction and causes pressure wave in the mercury and stress wave in the target container due to a sudden temperature change. Structural integrity of the target container depends on the power intensity at a maximum energy deposit. A broad proton profile is favorable to the structural assessment of the container rather than narrow one. Stress wave have propagated in the target container at a speed of sound. It only takes 0.1 ms for the size of 40 cm length stainless steel container. Further assessment is necessary to optimize a geometry of the container and establish a method to evaluate a life time. (author)

  2. Structural dynamic response of target container against proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Kikuchi, Kenji; Ishikura, Syuichi; Futakawa, Masatoshi; Hino, Ryutaro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-11-01

    Stress waves were analyzed for a target container of neutron science research project using a high-intensity proton accelerator that generates high energy and high current proton beam. In the mercury target, the pulsed proton beam generates intense power density in the course of spallation reaction and causes pressure wave in the mercury and stress wave in the target container due to a sudden temperature change. Structural integrity of the target container depends on the power intensity at a maximum energy deposit. A broad proton profile is favorable to the structural assessment of the container rather than narrow one. Stress wave have propagated in the target container at a speed of sound. It only takes 0.1 ms for the size of 40 cm length stainless steel container. Further assessment is necessary to optimize a geometry of the container and establish a method to evaluate a life time. (author)

  3. On a method for high-energy electron beam production in proton synchrotrons

    International Nuclear Information System (INIS)

    Bessonov, E.G.; Vazdik, Ya.A.

    1979-01-01

    It is suggested to produce high-energy electron beams in such a way that the ultrarelativistic protons give an amount of their kinetic energy to the electrons of a thin target, placed inside the working volume of the proton synchrotron. The kinematics of the elastic scattering of relativistic protons on electrons at rest is treated. Evaluation of a number of elastically-scattered electrons by 1000 GeV and 3000 GeV proton beams is presented. The method under consideration is of certain practical interest and may appear to be preferable in a definite energy range of protons and electrons

  4. The future and progress of proton beam radiotherapy

    International Nuclear Information System (INIS)

    Tsujii, Hirohiko

    1994-01-01

    The advantage of proton therapy is reduction of treatment volumes relative to those feasible with conventional photon therapy. The consequence is that the radiation dose to the target can be raised, with a resultant increase in tumor control probability. Proton beams, however, yield no biological gains because their biological properties are similar to conventional low LET radiations. As more sophisticated technologies are needed, there have been many advances which are applicable to photon therapy; 3-D treatment planning, DVH analysis, and systems for positioning, etc. As of January 1994, a total of about 13,000 cases were reported as having had treatments with proton beams in 16 centers world wide. The tumor sites for those include uveal melanoma (30-40%), intra-cranial small targets (40%), and others. Uveal melanomas had been most extensively treated with 70 Gy/5 fx or 60 Gy/4 fx which resulted in local control and survival rates of >96% and 80%, respectively. For chordoma and chondrosarcoma of the skull base and cervical spine, the 5 year local control rates were 65% and 91%, respectively. Promising results are also being obtained for head and neck and pelvic tumors. Deeper-seated tumors have been treated only at Tsukuba University with successful results in some anatomic sites. Among these, inoperable primary hepatocellular carcinomas were effectively treated with a total dose of 75-85 Gy (3.0-4.5 Gy/fx). The 3 year survival rates for all patients, Child A+B patient, and Child A patients were 38%, 47%, and 60%, respectively, which compare favorably to other modalities. These successful results of world wide proton therapy have led us to the conclusion that a hospital-based proton facility will provide opportunities for additional patients to be treated with protons. Thus, new plans are proposed from more than 10 institutions to build a new treatment center or upgrade the energy of currently available proton beams. (author)

  5. Relative and absolute dosimetry of proton therapy beams

    International Nuclear Information System (INIS)

    Mazal, A.; Delacroix, S.; Bridier, A.; Daures, J.; Dolo, J.M.; Nauraye, C.; Ferrand, R.; Cosgrave, V.; Habrand, J.L.

    1995-01-01

    Different codes of practice are in use or under preparation by several groups and national or international societies, concerning the dosimetry of proton beams. In spite of a large number of experiences and the increasing interest on this field, there are still large incertitudes on some of the basic conversion and correction factors to get dose values from different measuring methods. In practice, dose uniformity between centers is searched and encouraged by intercomparisons using standard procedures. We present the characteristics and the results on proton dosimetry intercomparisons using calorimeters, Faraday cups and ion chambers, as well as on the use of other detectors like diodes, radiographic films and TLD. New detectors like diamond, scintillators, radiochromic films, alanine, gels, ... can give new solutions to particular problems, provided their response is not affected at the end of the proton range (higher LET region), and their resolution, range, linearity, cost, ... are well adapted to practical situations. Some examples of special challenges are non interfering measurements during treatments for quality control, in vivo measurements, small beams for stereotactic irradiations, scanned beams and correlations between dosimetry, microdosimetry and radiobiology

  6. Proton beam shaped by “particle lens” formed by laser-driven hot electrons

    International Nuclear Information System (INIS)

    Zhai, S. H.; Shen, B. F.; Wang, W. P.; Zhang, H.; Zhang, L. G.; Huang, S.; Xu, Z. Z.; He, S. K.; Lu, F.; Zhang, F. Q.; Deng, Z. G.; Dong, K. G.; Wang, S. Y.; Zhou, K. N.; Xie, N.; Wang, X. D.; Liu, H. J.; Zhao, Z. Q.; Gu, Y. Q.; Zhang, B. H.

    2016-01-01

    Two-dimensional tailoring of a proton beam is realized by a “particle lens” in our experiment. A large quantity of electrons, generated by an intense femtosecond laser irradiating a polymer target, produces an electric field strong enough to change the trajectory and distribution of energetic protons flying through the electron area. The experiment shows that a strip pattern of the proton beam appears when hot electrons initially converge inside the plastic plate. Then the shape of the proton beam changes to a “fountain-like” pattern when these hot electrons diffuse after propagating a distance.

  7. Optimization of GATE and PHITS Monte Carlo code parameters for uniform scanning proton beam based on simulation with FLUKA general-purpose code

    Energy Technology Data Exchange (ETDEWEB)

    Kurosu, Keita [Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871 (Japan); Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871 (Japan); Takashina, Masaaki; Koizumi, Masahiko [Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871 (Japan); Das, Indra J. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202 (United States); Moskvin, Vadim P., E-mail: vadim.p.moskvin@gmail.com [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202 (United States)

    2014-10-01

    Although three general-purpose Monte Carlo (MC) simulation tools: Geant4, FLUKA and PHITS have been used extensively, differences in calculation results have been reported. The major causes are the implementation of the physical model, preset value of the ionization potential or definition of the maximum step size. In order to achieve artifact free MC simulation, an optimized parameters list for each simulation system is required. Several authors have already proposed the optimized lists, but those studies were performed with a simple system such as only a water phantom. Since particle beams have a transport, interaction and electromagnetic processes during beam delivery, establishment of an optimized parameters-list for whole beam delivery system is therefore of major importance. The purpose of this study was to determine the optimized parameters list for GATE and PHITS using proton treatment nozzle computational model. The simulation was performed with the broad scanning proton beam. The influences of the customizing parameters on the percentage depth dose (PDD) profile and the proton range were investigated by comparison with the result of FLUKA, and then the optimal parameters were determined. The PDD profile and the proton range obtained from our optimized parameters list showed different characteristics from the results obtained with simple system. This led to the conclusion that the physical model, particle transport mechanics and different geometry-based descriptions need accurate customization in planning computational experiments for artifact-free MC simulation.

  8. Optimization of GATE and PHITS Monte Carlo code parameters for uniform scanning proton beam based on simulation with FLUKA general-purpose code

    International Nuclear Information System (INIS)

    Kurosu, Keita; Takashina, Masaaki; Koizumi, Masahiko; Das, Indra J.; Moskvin, Vadim P.

    2014-01-01

    Although three general-purpose Monte Carlo (MC) simulation tools: Geant4, FLUKA and PHITS have been used extensively, differences in calculation results have been reported. The major causes are the implementation of the physical model, preset value of the ionization potential or definition of the maximum step size. In order to achieve artifact free MC simulation, an optimized parameters list for each simulation system is required. Several authors have already proposed the optimized lists, but those studies were performed with a simple system such as only a water phantom. Since particle beams have a transport, interaction and electromagnetic processes during beam delivery, establishment of an optimized parameters-list for whole beam delivery system is therefore of major importance. The purpose of this study was to determine the optimized parameters list for GATE and PHITS using proton treatment nozzle computational model. The simulation was performed with the broad scanning proton beam. The influences of the customizing parameters on the percentage depth dose (PDD) profile and the proton range were investigated by comparison with the result of FLUKA, and then the optimal parameters were determined. The PDD profile and the proton range obtained from our optimized parameters list showed different characteristics from the results obtained with simple system. This led to the conclusion that the physical model, particle transport mechanics and different geometry-based descriptions need accurate customization in planning computational experiments for artifact-free MC simulation

  9. Gate modulation of proton transport in a nanopore.

    Science.gov (United States)

    Mei, Lanju; Yeh, Li-Hsien; Qian, Shizhi

    2016-03-14

    Proton transport in confined spaces plays a crucial role in many biological processes as well as in modern technological applications, such as fuel cells. To achieve active control of proton conductance, we investigate for the first time the gate modulation of proton transport in a pH-regulated nanopore by a multi-ion model. The model takes into account surface protonation/deprotonation reactions, surface curvature, electroosmotic flow, Stern layer, and electric double layer overlap. The proposed model is validated by good agreement with the existing experimental data on nanopore conductance with and without a gate voltage. The results show that the modulation of proton transport in a nanopore depends on the concentration of the background salt and solution pH. Without background salt, the gated nanopore exhibits an interesting ambipolar conductance behavior when pH is close to the isoelectric point of the dielectric pore material, and the net ionic and proton conductance can be actively regulated with a gate voltage as low as 1 V. The higher the background salt concentration, the lower is the performance of the gate control on the proton transport.

  10. Luminescence imaging of water during proton-beam irradiation for range estimation

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Seiichi, E-mail: s-yama@met.nagoya-u.ac.jp; Okumura, Satoshi; Komori, Masataka [Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673 (Japan); Toshito, Toshiyuki [Department of Proton Therapy Physics, Nagoya Proton Therapy Center, Nagoya City West Medical Center, Nagoya 462-8508 (Japan)

    2015-11-15

    Purpose: Proton therapy has the ability to selectively deliver a dose to the target tumor, so the dose distribution should be accurately measured by a precise and efficient method. The authors found that luminescence was emitted from water during proton irradiation and conjectured that this phenomenon could be used for estimating the dose distribution. Methods: To achieve more accurate dose distribution, the authors set water phantoms on a table with a spot scanning proton therapy system and measured the luminescence images of these phantoms with a high-sensitivity, cooled charge coupled device camera during proton-beam irradiation. The authors imaged the phantoms of pure water, fluorescein solution, and an acrylic block. Results: The luminescence images of water phantoms taken during proton-beam irradiation showed clear Bragg peaks, and the measured proton ranges from the images were almost the same as those obtained with an ionization chamber. Furthermore, the image of the pure-water phantom showed almost the same distribution as the tap-water phantom, indicating that the luminescence image was not related to impurities in the water. The luminescence image of the fluorescein solution had ∼3 times higher intensity than water, with the same proton range as that of water. The luminescence image of the acrylic phantom had a 14.5% shorter proton range than that of water; the proton range in the acrylic phantom generally matched the calculated value. The luminescence images of the tap-water phantom during proton irradiation could be obtained in less than 2 s. Conclusions: Luminescence imaging during proton-beam irradiation is promising as an effective method for range estimation in proton therapy.

  11. Luminescence imaging of water during proton-beam irradiation for range estimation

    International Nuclear Information System (INIS)

    Yamamoto, Seiichi; Okumura, Satoshi; Komori, Masataka; Toshito, Toshiyuki

    2015-01-01

    Purpose: Proton therapy has the ability to selectively deliver a dose to the target tumor, so the dose distribution should be accurately measured by a precise and efficient method. The authors found that luminescence was emitted from water during proton irradiation and conjectured that this phenomenon could be used for estimating the dose distribution. Methods: To achieve more accurate dose distribution, the authors set water phantoms on a table with a spot scanning proton therapy system and measured the luminescence images of these phantoms with a high-sensitivity, cooled charge coupled device camera during proton-beam irradiation. The authors imaged the phantoms of pure water, fluorescein solution, and an acrylic block. Results: The luminescence images of water phantoms taken during proton-beam irradiation showed clear Bragg peaks, and the measured proton ranges from the images were almost the same as those obtained with an ionization chamber. Furthermore, the image of the pure-water phantom showed almost the same distribution as the tap-water phantom, indicating that the luminescence image was not related to impurities in the water. The luminescence image of the fluorescein solution had ∼3 times higher intensity than water, with the same proton range as that of water. The luminescence image of the acrylic phantom had a 14.5% shorter proton range than that of water; the proton range in the acrylic phantom generally matched the calculated value. The luminescence images of the tap-water phantom during proton irradiation could be obtained in less than 2 s. Conclusions: Luminescence imaging during proton-beam irradiation is promising as an effective method for range estimation in proton therapy

  12. Structural design study of a proton beam window for a 1-MW spallation neutron source

    Energy Technology Data Exchange (ETDEWEB)

    Teraoku, Takuji; Terada, Atsuhiko; Maekawa, Fujio; Meigo, Shin-ichiro; Kaminaga, Masanori; Ishikura, Syuichi; Hino, Ryutaro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2003-03-01

    A 1-MW spallation neutron source aiming at materials and life science researches will be constructed under the JAERI-KEK High-intensity Proton Accelerator Project (J-PARC). A proton beam passes through a proton beam window, and be injected into a target of the neutron source. The proton beam window functions as a boundary wall between a high vacuum area in the proton beam line and a helium atmosphere at about atmospheric pressure in a helium vessel which contains the target and moderators. The proton beam window is cooled by light water because high heat-density is generated in the window material by interactions with the proton beam. Then, uniformity of the water flow is requested at the window to suppress a hot-spot that causes excessive thermal stress and cooling water boiling. Also, the window has to be strong enough in its structure for inner stress due to water pressure and thermal stress due to heat generation. In this report, we propose two types of proton beam windows; one flat-type that is easy to manufacture, and the other, curved-type that has high stress resistivity. As a part of design study for the windows, evaluation of strength of structure and thermal hydraulic analysis were conducted. As a result, it was found that sufficient heat removal was assured with uniform water flow at the window, and stress caused by internal water pressure and thermal stress could be maintained below allowable stress values. Accordingly, it was confirmed that the proton beam window designs were feasible. (author)

  13. Study on the proton-induced X-ray emission(PIXE) using external proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, M. Y.; Yoon, J. C.; Park, K. J. [Seoul Natioanl University, Seoul (Korea, Republic of)

    2008-04-15

    We intend to develop a system that can extract a proton beam into air for a qualitative, and quantitative PIXE analysis up to ppm(percent per million) composition. When such an R and D is accomplished, first it is possible to get equipped with a system for PIXE and PIGmE, second, it is possible to contribute to an academic progress by the study for physical properties of matter through an nuclear science methods when the comparison between the measurement and the calculated quantities, and third, it is possible to contribute to a multi-disciplinary researches by the measurements of the samples for which it is hard to get the SRM for the samples. We intend to develop methods to measure the beam current for an air-borne proton beam, and to minimize the energy and current loss of the beam. We intend to acquire a set of PIXE data for rare-earth metals and transient metals, to form a basic database for the analysis for various samples for which it is hard to get the SRM. Developed PIXE beamline can extract the beam diameter up to 5mm, and beam intensity in the range 0.5nA to 10nA variable. sustaining the vacuum better than 10{sup -6} mtorr. Necessary detection system and methodology are complete. As the application of the present research achievements, we studied the analysis of aerosol composition, the appraisal of the cultural heritages, and a feasibility study for a proton beam writing. It is expected to become possible to analyse the compositions of the gems, the elemental compositions of the food, the discrimination of the traditional ink and the modern ink on the documents, the evaluation of the documents by the analysis of the elemental composition of the stamps, The analysis of the paper with respect to the date and the quality, the analysis of the color, and the core bored samples

  14. Electron clearing for the ISA proton beam

    International Nuclear Information System (INIS)

    Herrera, J.C.

    1976-01-01

    The circulating protons in the ISABELLE intersecting storage ring accelerator will collide with the residual gas in the vacuum chamber. The electrons produced will tend to be captured by the potential well of the beam itself and result in a neutralization of the space charge of the beam. A detailed analysis is given of the various mechanisms which can be used to reduce the net degree of beam neutralization. It is concluded that the average neutralization will be about 10 -4 for a residual gas pressure of 3 x 10 -11 torr of hydrogen

  15. An analytical reconstruction model of the spread-out Bragg peak using laser-accelerated proton beams.

    Science.gov (United States)

    Tao, Li; Zhu, Kun; Zhu, Jungao; Xu, Xiaohan; Lin, Chen; Ma, Wenjun; Lu, Haiyang; Zhao, Yanying; Lu, Yuanrong; Chen, Jia-Er; Yan, Xueqing

    2017-07-07

    With the development of laser technology, laser-driven proton acceleration provides a new method for proton tumor therapy. However, it has not been applied in practice because of the wide and decreasing energy spectrum of laser-accelerated proton beams. In this paper, we propose an analytical model to reconstruct the spread-out Bragg peak (SOBP) using laser-accelerated proton beams. Firstly, we present a modified weighting formula for protons of different energies. Secondly, a theoretical model for the reconstruction of SOBPs with laser-accelerated proton beams has been built. It can quickly calculate the number of laser shots needed for each energy interval of the laser-accelerated protons. Finally, we show the 2D reconstruction results of SOBPs for laser-accelerated proton beams and the ideal situation. The final results show that our analytical model can give an SOBP reconstruction scheme that can be used for actual tumor therapy.

  16. An improved 8 GeV beam transport system for the Fermi National Accelerator Laboratory

    International Nuclear Information System (INIS)

    Syphers, M.J.

    1987-06-01

    A new 8 GeV beam transport system between the Booster and Main Ring synchrotrons at the Fermi National Accelerator Laboratory is presented. The system was developed in an effort to improve the transverse phase space area occupied by the proton beam upon injection into the Main Ring accelerator. Problems with the original system are described and general methods of beamline design are formulated. Errors in the transverse properties of a beamline at the injection point of the second synchrotron and their effects on the region in transverse phase space occupied by a beam of particles are discussed. Results from the commissioning phase of the project are presented as well as measurements of the degree of phase space dilution generated by the transfer of 8 GeV protons from the Booster synchrotron to the Main Ring synchrotron

  17. SU-C-204-02: Behavioral and Pathologic Differences in Mice Exposed to Proton Minibeam Arrays Versus Proton Broad Beams

    International Nuclear Information System (INIS)

    Eley, J; Zhang, C; Wolfe, T; Vichaya, E; Quini, C; Chadha, A; Sahoo, N; Krishnan, S; Davis, J; Dilmanian, F

    2016-01-01

    Purpose: Minibeam therapy using protons or light-ions offers a theoretical reduction of biologic damage to tissues upstream of a tumor compared to broad-beam therapy while providing equal tumor control. The purpose of this study was to investigate behavioral and pathologic differences in mice after exposure of healthy brain to proton minibeam arrays versus proton broad beams. Methods: Twenty-four C57BL/6J juvenile mice were divided into 5 study arms: sham irradiation (NoRT), broad-beam 10 Gy (BB10), minibeam 10Gy (MB10), broad-beam 30 Gy (BB30), and minibeam 30 Gy (MB30), approximate integral entrance doses. Circular beams of 100 MeV protons with 7-mm diameter were delivered laterally through the brain, either as broad beams or as planar minibeam arrays having 300-micron beam width and 1-mm spacing on center. Mice were followed for 8 months using standard behavioral tests. Pathologic studies were carried out at 8 months after irradiation. Results: Peak entrance doses were 10.0, 23.8, 30.0, and 71.3 Gy for mice in BB10, MB10, BB30, and MB30, respectively. Despite the high single-fraction doses, no animals showed signs of radiation sickness or neurophysical impairment over the 8-month study duration. The Morris water maze alternate-starting-position trial showed significant evidence of better spatial learning for mice in MB10 versus BB10 (p=0.026), but other behavioral tests showed no significant differences. Glial fibrillary acidic protein stains showed gliosis in arms BB10, BB30, and MB30 but not in NoRT or MB10. A secondary finding was categorically higher epilation in broad-beam arms compared with their minibeam dose counterparts. Conclusion: Our findings indicate trends that, despite the higher peak doses, proton minibeam therapy can reduce radiation side effects in shallow tissue and brain compared to proton broadbeam therapy. As the behavioral findings were mixed, confirmation studies are needed with larger numbers of animals. AAPM Research Seed Funding Grant

  18. SU-C-204-02: Behavioral and Pathologic Differences in Mice Exposed to Proton Minibeam Arrays Versus Proton Broad Beams

    Energy Technology Data Exchange (ETDEWEB)

    Eley, J; Zhang, C [University of Maryland School of Medicine, Baltimore, MD (United States); Wolfe, T; Vichaya, E; Quini, C; Chadha, A; Sahoo, N; Krishnan, S [The University of Texas MD Anderson Cancer Center, Houston, TX (United States); Davis, J; Dilmanian, F [Stony Brook University Medical Center, Stony Brook, NY (United States)

    2016-06-15

    Purpose: Minibeam therapy using protons or light-ions offers a theoretical reduction of biologic damage to tissues upstream of a tumor compared to broad-beam therapy while providing equal tumor control. The purpose of this study was to investigate behavioral and pathologic differences in mice after exposure of healthy brain to proton minibeam arrays versus proton broad beams. Methods: Twenty-four C57BL/6J juvenile mice were divided into 5 study arms: sham irradiation (NoRT), broad-beam 10 Gy (BB10), minibeam 10Gy (MB10), broad-beam 30 Gy (BB30), and minibeam 30 Gy (MB30), approximate integral entrance doses. Circular beams of 100 MeV protons with 7-mm diameter were delivered laterally through the brain, either as broad beams or as planar minibeam arrays having 300-micron beam width and 1-mm spacing on center. Mice were followed for 8 months using standard behavioral tests. Pathologic studies were carried out at 8 months after irradiation. Results: Peak entrance doses were 10.0, 23.8, 30.0, and 71.3 Gy for mice in BB10, MB10, BB30, and MB30, respectively. Despite the high single-fraction doses, no animals showed signs of radiation sickness or neurophysical impairment over the 8-month study duration. The Morris water maze alternate-starting-position trial showed significant evidence of better spatial learning for mice in MB10 versus BB10 (p=0.026), but other behavioral tests showed no significant differences. Glial fibrillary acidic protein stains showed gliosis in arms BB10, BB30, and MB30 but not in NoRT or MB10. A secondary finding was categorically higher epilation in broad-beam arms compared with their minibeam dose counterparts. Conclusion: Our findings indicate trends that, despite the higher peak doses, proton minibeam therapy can reduce radiation side effects in shallow tissue and brain compared to proton broadbeam therapy. As the behavioral findings were mixed, confirmation studies are needed with larger numbers of animals. AAPM Research Seed Funding Grant.

  19. Proton-Beam Therapy for Olfactory Neuroblastoma

    International Nuclear Information System (INIS)

    Nishimura, Hideki; Ogino, Takashi; Kawashima, Mitsuhiko; Nihei, Keiji; Arahira, Satoko; Onozawa, Masakatsu; Katsuta, Shoichi; Nishio, Teiji

    2007-01-01

    Purpose: To analyze the feasibility and efficacy of proton-beam therapy (PBT) for olfactory neuroblastoma (ONB) as a definitive treatment, by reviewing our preliminary experience. Olfactory neuroblastoma is a rare disease, and a standard treatment strategy has not been established. Radiation therapy for ONB is challenging because of the proximity of ONBs to critical organs. Proton-beam therapy can provide better dose distribution compared with X-ray irradiation because of its physical characteristics, and is deemed to be a feasible treatment modality. Methods and Materials: A retrospective review was performed on 14 patients who underwent PBT for ONB as definitive treatment at the National Cancer Center Hospital East (Kashiwa, Chiba, Japan) from November 1999 to February 2005. A total dose of PBT was 65 cobalt Gray equivalents (Gy E ), with 2.5-Gy E once-daily fractionations. Results: The median follow-up period for surviving patients was 40 months. One patient died from disseminated disease. There were two persistent diseases, one of which was successfully salvaged with surgery. The 5-year overall survival rate was 93%, the 5-year local progression-free survival rate was 84%, and the 5-year relapse-free survival rate was 71%. Liquorrhea was observed in one patient with Kadish's stage C disease (widely destroying the skull base). Most patients experienced Grade 1 to 2 dermatitis in the acute phase. No other adverse events of Grade 3 or greater were observed according to the RTOG/EORTC acute and late morbidity scoring system. Conclusions: Our preliminary results of PBT for ONB achieved excellent local control and survival outcomes without serious adverse effects. Proton-beam therapy is considered a safe and effective modality that warrants further study

  20. Structural activation calculations due to proton beam loss in the APT accelerator design

    International Nuclear Information System (INIS)

    Lee, S. K.; Beard, C. A.; Wilson, W. B.; Daemen, L. L.; Liska, D. J.; Waters, L. S.; Adams, M. L.

    1995-01-01

    For the new, high-power accelerators currently being designed, the amount of activation of the accelerator structure has become an important issue. To quantify this activation, a methodology was utilized that coupled transport and depletion codes to obtain dose rate estimates at several locations near the accelerator. This research focused on the 20 and 100 MeV sections of the Bridge-Coupled Drift Tube Linear Accelerator. The peak dose rate was found to be approximately 6 mR/hr in the 100 MeV section near the quadrupoles at a 25-cm radius for an assumed beam loss of 1 nA/m. It was determined that the activation was dominated by the proton interactions and subsequent spallation product generation, as opposed to the presence of the generated neutrons. The worst contributors were the spallation products created by proton bombardment of iron, and the worst component was the beam pipe, which consists mostly of iron. No definitive conclusions about the feasibility of hands-on maintenance can be determined, as the design is still not finalized

  1. Structural activation calculations due to proton beam loss in the APT accelerator design

    International Nuclear Information System (INIS)

    Lee, S.K.; Beard, C.A.; Wilson, W.B.; Daemen, L.L.; Liska, D.J.; Waters, L.S.; Adams, M.L.

    1994-01-01

    For the new, high-power accelerators currently being designed, the amount of activation of the accelerator structure has become an important issue. To quantify this activation, a methodology was utilized that coupled transport and depletion codes to obtain dose rate estimates at several locations near the accelerator. This research focused on the 20 and 100 MeV sections of the Bridge-Coupled Drift Tube Linear Accelerator. The peak dose rate was found to be approximately 6 mR/hr in the 100 MeV section near the quadrupoles at a 25-cm radius for an assumed beam loss of 1 nA/m. It was determined that the activation was dominated by the proton interactions and subsequent spallation product generation, as opposed to the presence of the generated neutrons. The worst contributors were the spallation products created by proton bombardment of iron, and the worst component was the beam pipe, which consists mostly of iron. No definitive conclusions about the feasibility of hands-on maintenance can be determined, as the design is still not finalized

  2. Relative biological effectiveness of the therapeutic proton beams at NIRS and Tsukuba University

    International Nuclear Information System (INIS)

    Ando, Koichi; Koike, Sachiko; Kawachi, Kiyomitsu

    1985-01-01

    Relative biological effectiveness (RBE) of proton beams dedicated to radiotherapy was examined using a method of simultaneous irradiation. Mice received i.v. transplantation of syngeneic fibrosarcoma (NFSa) cells. These mice were divided into 3 groups on the following day, and thorax was simultaneously irradiated with one of the following beams: 70MeV proton beam at National Institute of Radiological Sciences (NIRS), 250 MeV Proton beam at Tsukuba University (PARMS) and 60 Co γ ray. Ten to 13 days thereafter, lungs were removed for colony counts to give dose-cell survival relationships. RBE of NIRS proton was ranging from 1.01 to 1.12 with an average of 1.06 while that of PARMS proton was ranging from 1.03 to 1.09 with an average of 1.06 at surviving fraction of 0.01. The simultaneous irradiation for RBE study was found to be reliable at large dose-low survival regions. (author)

  3. Microdosimetric Characteristics of the Clinical Proton Beams at the JINR Phasotron, Dubna

    CERN Document Server

    Vlcek, B; Spurny, F

    2002-01-01

    The contribution of the high LET particles to dosimetric and microdosimetric characteristics of 150 and 205 MeV clinical proton beams was experimentally studied using track etched detectors. Secondary heavy charged particles produced from nuclear interactions and degraded protons at the Bragg peak region are particles with high LET. The method of the LET spectra measurement with track etched detectors allows one to determine the contribution of high LET particles to dosimetric characteristics of clinical proton beams: absorbed dose, equivalent dose and the value of the Relative Biological Effectiveness (RBE). Track detectors were irradiated in the various depth of clinical proton beams with the primary energies of 150 and 205 MeV. The LET spectra between 10 and 700 keV/m were measured by means of CR-39 track etched detectors and the automatic optical image analyzer LUCIA-II. The relative contribution of the high LET particles to absorbed dose increases from several per cent at the beam entrance to several ten...

  4. The study of PDMS surface treatment and it's applications by using proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Baek, J. Y.; Kim, J. Y.; Kwon, K. H.; Park, J. Y. [Korea Univ., Seoul (Korea, Republic of)

    2007-04-15

    PDMS(Polydimethylsiloxane) is mainly used as a material to do lab on a chip for biochemical analysis. PDMS has many applicability at the Bio-Technology(BT) field, because it is flexible, biocompatible and has good oxygen permeability. In this study, we have investigated to physical and chemical changes of PDMS surface by proton beam radiation conditions. The used kind of ion were Ar and N, beam energy was 30keV, 60keV, 80keV, total fluence was 1E10 to 1E16 [ions/cm{sup 2}]. PDMS membrane was produced as 150 {mu}m thick on the 3' silicon wafer. We inquired into physical and chemical changes up to beam radiation conditions through the investigate the change of surface roughness by AFM(Atomic Force Microscope), the change of surface morphology by SEM(Scanning Electron Microscope) and the change of chemical composition by FT-IR(Fourier Transform Infrared Raman spectroscopy) and XPS(X-ray Photoelectron Spectroscopy). From these basic data to we set up the proton beam radiation conditions to secure metal layer and PDMS adhesion. This enables to produce the electrode at the PDMS material lab on a chip. From now on, we'll investigate the cell patterning possibility after carry out of cell culture with mouse fibroblast at PDMS surface what is surface modification by using of proton beam radiation and apply this to produce lab on a chip. Physical property: Surface roughness of PDMS membrane was observed using AFM, after exposure of proton beam on it. The roughness increased as the power level of proton beam increase. This phenomena was caused by the kinetic energy of particle. Chemical property: Long term observation was conducted on the contact angles of the samples made by the proton beam exposure or oxygen plasma treatment; the hydrophilicity was found to be stronger in the samples made by the proton beam exposure. We found the reason of this was the destruction of polymer chains by proton beam. Feasibility of Through-hole: Considering that comparatively high

  5. The role of a microDiamond detector in the dosimetry of proton pencil beams

    Energy Technology Data Exchange (ETDEWEB)

    Goma, Carles [Paul Scherrer Institute, Villigen (Switzerland). Centre for Proton Therapy; Swiss Federal Institute of Technology Zurich (Switzerland). Dept. of Physics; Marinelli, Marco; Verona-Rinati, Gianluca [Roma Univ. ' ' Tor Vergata' ' (Italy). Dipt. di Ingegneria Industriale; INFN, Roma (Italy); Safai, Sairos [Paul Scherrer Institute, Villigen (Switzerland). Centre for Proton Therapy; Wuerfel, Jan [PTW-Freiburg, Freiburg (Germany)

    2016-05-01

    In this work, the performance of a microDiamond detector in a scanned proton beam is studied and its potential role in the dosimetric characterization of proton pencil beams is assessed. The linearity of the detector response with the absorbed dose and the dependence on the dose-rate were tested. The depth-dose curve and the lateral dose profiles of a proton pencil beam were measured and compared to reference data. The feasibility of calibrating the beam monitor chamber with a microDiamond detector was also studied. It was found the detector reading is linear with the absorbed dose to water (down to few cGy) and the detector response is independent of both the dose-rate (up to few Gy/s) and the proton beam energy (within the whole clinically-relevant energy range). The detector showed a good performance in depth-dose curve and lateral dose profile measurements; and it might even be used to calibrate the beam monitor chambers-provided it is cross-calibrated against a reference ionization chamber. In conclusion, the microDiamond detector was proved capable of performing an accurate dosimetric characterization of proton pencil beams.

  6. Control of proton beam divergence in intense-laser foil-plasma interaction

    International Nuclear Information System (INIS)

    Kawata, S.; Sonobe, R.; Miyazaki, S.; Sakai, K.; Kikuchi, T.

    2006-01-01

    Quality of an ion beam is one of the critical factors in intense-laser ion beam generation. A purpose of this study is the suppression of transverse proton divergence by a controlled electron cloud in laser-foil interactions. In this study, the foil target has a hole at the opposite side of the laser illumination. The electrons accelerated by an intense laser are limited in transverse by a neutral plasma at a protuberant part. Therefore the protons are accelerated and also controlled transversely by the electron cloud structure. In our 2.5-dimensional Particle-in-Cell simulations we demonstrate that the transverse shape of the electron cloud is well controlled and the collimated proton beam is generated successfully in the target with the hole. (authors)

  7. Study of the Clinical Proton Beam Relative Biological Effectiveness at the JINR Phasotron, Dubna

    CERN Document Server

    Vitanova, A; Gaevskii, V N; Molokonov, A G; Spurny, F; Fadeeva, T A; Shmakova, N L

    2002-01-01

    Proton clinical beams contain particles with high linear energy transfer (LET). Secondary heavy charged particles produced from nuclear interactions and degraded protons at the Bragg peak region are particles with high LET. These particles could enhance the Relative Biological Effectiveness (RBE) of the proton beam. We have carried out two radiobiological experiments to investigate the RBE of 150 MeV clinical proton beam. The irradiation of the Chinese Hamster V79 cells were performed at two points of the depth-dose distribution - at the beam entrance and at the Bragg peak. The contribution of the high LET particles to dosimetric and microdosimetric characteristics in the various depth of proton beam was also experimentally studied using the CR-39 track etched detectors. The LET spectra between 10 and 700 keV/{\\mu}m were measured by means of track detectors and the automatic optical image analyzer LUCIA-II. The relative contribution of the high LET particles to ab! sorbed dose increases from several per cent ...

  8. Advanced applications in microphotonics using proton beam writing

    International Nuclear Information System (INIS)

    Bettiol, A.A.; Chiam, S.Y.; Teo, E.J.; Udalagama, C.; Chan, S.F.; Hoi, S.K.; Kan, J.A. van; Breese, M.B.H.; Watt, F.

    2009-01-01

    Proton beam writing (PBW) is a powerful tool for prototyping microphotonic structures in a wide variety of materials including polymers, insulators, semiconductors and metals. Prototyping is achieved either through direct fabrication with the proton beam, or by the fabrication of a master that can be used for replication. In recent times we have explored the use of PBW for various advanced optical applications including fabrication of subwavelength metallic structures and metamaterials, direct write of silicon waveguides for mid IR applications and integrated waveguides for lab-on-a-chip devices. This paper will review the recent progress made in these areas with particular emphasis on the main advantages of using the PBW technique for these novel applications.

  9. Influence of micromachined targets on laser accelerated proton beam profiles

    Science.gov (United States)

    Dalui, Malay; Permogorov, Alexander; Pahl, Hannes; Persson, Anders; Wahlström, Claes-Göran

    2018-03-01

    High intensity laser-driven proton acceleration from micromachined targets is studied experimentally in the target-normal-sheath-acceleration regime. Conical pits are created on the front surface of flat aluminium foils of initial thickness 12.5 and 3 μm using series of low energy pulses (0.5-2.5 μJ). Proton acceleration from such micromachined targets is compared with flat foils of equivalent thickness at a laser intensity of 7 × 1019 W cm-2. The maximum proton energy obtained from targets machined from 12.5 μm thick foils is found to be slightly lower than that of flat foils of equivalent remaining thickness, and the angular divergence of the proton beam is observed to increase as the depth of the pit approaches the foil thickness. Targets machined from 3 μm thick foils, on the other hand, show evidence of increasing the maximum proton energy when the depths of the structures are small. Furthermore, shallow pits on 3 μm thick foils are found to be efficient in reducing the proton beam divergence by a factor of up to three compared to that obtained from flat foils, while maintaining the maximum proton energy.

  10. Fabrication and optimization of a fiber-optic radiation sensor for proton beam dosimetry

    International Nuclear Information System (INIS)

    Jang, K.W.; Yoo, W.J.; Seo, J.K.; Heo, J.Y.; Moon, J.; Park, J.-Y.; Hwang, E.J.; Shin, D.; Park, S.-Y.; Cho, H.-S.; Lee, B.

    2011-01-01

    In this study, we fabricated a fiber-optic radiation sensor for proton therapy dosimetry and measured the output and the peak-to-plateau ratio of scintillation light with various kinds of organic scintillators in order to select an organic scintillator appropriate for measuring the dose of a proton beam. For the optimization of an organic scintillator, the linearity between the light output and the stopping power of a proton beam was evaluated for two different diameters of the scintillator, and the angular dependency and standard deviation of the light pulses were investigated for four different scintillator lengths. We also evaluated the linearity between the light output and the dose rate and monitor units of a proton generator, respectively. The relative depth-dose curve of the proton beam was obtained and corrected using Birk's theory.

  11. Experimental control of the beam properties of laser-accelerated protons and carbon ions

    Energy Technology Data Exchange (ETDEWEB)

    Amin, Munib

    2008-12-15

    The laser generation of energetic high quality beams of protons and heavier ions has opened up the door to a plethora of applications. These beams are usually generated by the interaction of a short pulse high power laser with a thin metal foil target. They could already be applied to probe transient phenomena in plasmas and to produce warm dense matter by isochoric heating. Other applications such as the production of radioisotopes and tumour radiotherapy need further research to be put into practice. To meet the requirements of each application, the properties of the laser-accelerated particle beams have to be controlled precisely. In this thesis, experimental means to control the beam properties of laser-accelerated protons and carbon ions are investigated. The production and control of proton and carbon ion beams is studied using advanced ion source designs: Experiments concerning mass-limited (i.e. small and isolated) targets are conducted. These targets have the potential to increase both the number and the energy of laser-accelerated protons. Therefore, the influence of the size of a plane foil target on proton beam properties is measured. Furthermore, carbon ion sources are investigated. Carbon ions are of particular interest in the production of warm dense matter and in cancer radiotherapy. The possibility to focus carbon ion beams is investigated and a simple method for the production of quasi-monoenergetic carbon ion beams is presented. This thesis also provides an insight into the physical processes connected to the production and the control of laser-accelerated ions. For this purpose, laser-accelerated protons are employed to probe plasma phenomena on laser-irradiated targets. Electric fields evolving on the surface of laser-irradiated metal foils and hollow metal foil cylinders are investigated. Since these fields can be used to displace, collimate or focus proton beams, understanding their temporal and spatial evolution is crucial for the design of

  12. Experimental control of the beam properties of laser-accelerated protons and carbon ions

    International Nuclear Information System (INIS)

    Amin, Munib

    2008-12-01

    The laser generation of energetic high quality beams of protons and heavier ions has opened up the door to a plethora of applications. These beams are usually generated by the interaction of a short pulse high power laser with a thin metal foil target. They could already be applied to probe transient phenomena in plasmas and to produce warm dense matter by isochoric heating. Other applications such as the production of radioisotopes and tumour radiotherapy need further research to be put into practice. To meet the requirements of each application, the properties of the laser-accelerated particle beams have to be controlled precisely. In this thesis, experimental means to control the beam properties of laser-accelerated protons and carbon ions are investigated. The production and control of proton and carbon ion beams is studied using advanced ion source designs: Experiments concerning mass-limited (i.e. small and isolated) targets are conducted. These targets have the potential to increase both the number and the energy of laser-accelerated protons. Therefore, the influence of the size of a plane foil target on proton beam properties is measured. Furthermore, carbon ion sources are investigated. Carbon ions are of particular interest in the production of warm dense matter and in cancer radiotherapy. The possibility to focus carbon ion beams is investigated and a simple method for the production of quasi-monoenergetic carbon ion beams is presented. This thesis also provides an insight into the physical processes connected to the production and the control of laser-accelerated ions. For this purpose, laser-accelerated protons are employed to probe plasma phenomena on laser-irradiated targets. Electric fields evolving on the surface of laser-irradiated metal foils and hollow metal foil cylinders are investigated. Since these fields can be used to displace, collimate or focus proton beams, understanding their temporal and spatial evolution is crucial for the design of

  13. Mutant breeding of ornamental trees for creating variations with high value using proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Yim, Jae Hong; Woo, Seong Min; Hwang, Mun Joo; Pyo, Sun Hui [Phygen, Daejeon (Korea, Republic of); Kwon, Hye Jin [Environmental-Friendly Agriculture Research Institute, Seoul (Korea, Republic of); Woo, Jong Suk [Cheonan Yonam College, Cheonan (Korea, Republic of)

    2010-04-15

    This research was conducted to investigate the proton-beam radiation sensitivity and seed germination rate of 18 ornamental plants and to survey the quantitative characteristics of proton beam induced strains. To induce the variants of ornamental plants, seeds were irradiated at the dose of 0{approx} 2kGy of proton beam at room temperature by 45 MeV MC-50 Cyclotron. After irradiation, to assess the effects of proton beam on radiation sensitivity and morphological changes of the plants and the seed germination rate were analysed. The effects of mutation induction by proton beam irradiation on seeds in Lagerstroemia indica and Ligustrum obtusifolium were investigated. Irradiation with proton beam at the dose of 750Gy induced mutants in leaf length, leaf width, internode length, plant height, leaf color, autumn leaves and plant width in each strains. According to a principal component analysis, the induced strains were divided into three groups. Promising strain(strain 25) for commercial varieties was selected Lagerstroemia indica. It was analysed that strain 25 showed the highest genetic dissimility from original species. The strain 25 had red leaf edge and maintained autumnal tints till late fall. So, we try to promote a patent registration of the strain 25 as a new caltivar 'Bulkkot'

  14. Mutant breeding of ornamental trees for creating variations with high value using proton beam

    International Nuclear Information System (INIS)

    Yim, Jae Hong; Woo, Seong Min; Hwang, Mun Joo; Pyo, Sun Hui; Kwon, Hye Jin; Woo, Jong Suk

    2010-04-01

    This research was conducted to investigate the proton-beam radiation sensitivity and seed germination rate of 18 ornamental plants and to survey the quantitative characteristics of proton beam induced strains. To induce the variants of ornamental plants, seeds were irradiated at the dose of 0∼ 2kGy of proton beam at room temperature by 45 MeV MC-50 Cyclotron. After irradiation, to assess the effects of proton beam on radiation sensitivity and morphological changes of the plants and the seed germination rate were analysed. The effects of mutation induction by proton beam irradiation on seeds in Lagerstroemia indica and Ligustrum obtusifolium were investigated. Irradiation with proton beam at the dose of 750Gy induced mutants in leaf length, leaf width, internode length, plant height, leaf color, autumn leaves and plant width in each strains. According to a principal component analysis, the induced strains were divided into three groups. Promising strain(strain 25) for commercial varieties was selected Lagerstroemia indica. It was analysed that strain 25 showed the highest genetic dissimility from original species. The strain 25 had red leaf edge and maintained autumnal tints till late fall. So, we try to promote a patent registration of the strain 25 as a new caltivar 'Bulkkot'

  15. Comparison of surface doses from spot scanning and passively scattered proton therapy beams

    International Nuclear Information System (INIS)

    Arjomandy, Bijan; Sahoo, Narayan; Gillin, Michael; Cox, James; Lee, Andrew

    2009-01-01

    Proton therapy for the treatment of cancer is delivered using either passively scattered or scanning beams. Each technique delivers a different amount of dose to the skin, because of the specific feature of their delivery system. The amount of dose delivered to the skin can play an important role in choosing the delivery technique for a specific site. To assess the differences in skin doses, we measured the surface doses associated with these two techniques. For the purpose of this investigation, the surface doses in a phantom were measured for ten prostate treatment fields planned with passively scattered proton beams and ten patients planned with spot scanning proton beams. The measured doses were compared to evaluate the differences in the amount of skin dose delivered by using these techniques. The results indicate that, on average, the patients treated with spot scanning proton beams received lower skin doses by an amount of 11.8% ± 0.3% than did the patients treated with passively scattered proton beams. That difference could amount to 4 CGE per field for a prescribed dose of 76 CGE in 38 fractions treated with two equally weighted parallel opposed fields. (note)

  16. SU-F-T-137: Out-Of-Beam Dose for a Compact Double-Scattering Proton Beam Therapy System

    Energy Technology Data Exchange (ETDEWEB)

    Islam, M; Ahmad, S; Jin, H [University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States)

    2016-06-15

    Purpose: The out-of-beam dose is important for understanding the peripheral dose in radiation therapy. In proton radiotherapy, the study of out-of-beam dose is scarce and the treatment planning system (TPS) based on pencil beam algorithm cannot accurately predict the out-of-beam dose. This study investigates the out-of-beam dose for the single-room Mevion S250 double scattering proton therapy system using experimentally measured and treatment planning software generated data. The results are compared with those reported for conventional photon beam therapy. However, this study does not incorporate the neutron contribution in the scattered dose. Methods: A total of seven proton treatment plans were generated using Varian Eclipse TPS for three different sites (brain, lung, and pelvis) in an anthropomorphic phantom. Three field sizes of 5×5, 10×10, and 20×20 cm{sup 2} (lung only) with typical clinical range (13.3–22.8 g/cm{sup 2}) and modulation widths (5.3–14.0 g/cm{sup 2}) were used. A single beam was employed in each treatment plan to deliver a dose of 181.8 cGy (200.0 cGy (RBE)) to the selected target. The out-of-beam dose was measured at 2.0, 5.0, 10.0, and 15.0 cm from the beam edge in the phantom using a thimble chamber (PTW TN31010). Results: The out-of-beam dose generally increased with field size, range, and volume irradiated. For all the plans, the scattered dose sharply fell off with distance. At 2.0 cm, the out-of-beam dose ranged from 0.35% to 2.16% of the delivered dose; however, the dose was clinically negligible (<0.3%) at a distance of 5.0 cm and greater. In photon therapy, the slightly greater out-of-beam dose was reported (TG36; 4%, 2%, and 1% for 2.0, 5.0, and 10.0 cm, respectively, using 6 MV beam). Conclusion: The measured out-of-beam dose in proton therapy excluding neutron contribution was observed higher than the TPS calculated dose and comparable to that of photon beam therapy.

  17. Radiographic film dosimetry of proton beams for depth‐dose constancy check and beam profile measurement

    Science.gov (United States)

    Teran, Anthony; Ghebremedhin, Abiel; Johnson, Matt; Patyal, Baldev

    2015-01-01

    Radiographic film dosimetry suffers from its energy dependence in proton dosimetry. This study sought to develop a method of measuring proton beams by the film and to evaluate film response to proton beams for the constancy check of depth dose (DD). It also evaluated the film for profile measurements. To achieve this goal, from DDs measured by film and ion chamber (IC), calibration factors (ratios of dose measured by IC to film responses) as a function of depth in a phantom were obtained. These factors imply variable slopes (with proton energy and depth) of linear characteristic curves that relate film response to dose. We derived a calibration method that enables utilization of the factors for acquisition of dose from film density measured at later dates by adapting to a potentially altered processor condition. To test this model, the characteristic curve was obtained by using EDR2 film and in‐phantom film dosimetry in parallel with a 149.65 MeV proton beam, using the method. An additional validation of the model was performed by concurrent film and IC measurement perpendicular to the beam at various depths. Beam profile measurements by the film were also evaluated at the center of beam modulation. In order to interpret and ascertain the film dosimetry, Monte Carlos simulation of the beam was performed, calculating the proton fluence spectrum along depths and off‐axis distances. By multiplying respective stopping powers to the spectrum, doses to film and water were calculated. The ratio of film dose to water dose was evaluated. Results are as follows. The characteristic curve proved the assumed linearity. The measured DD approached that of IC, but near the end of the spread‐out Bragg peak (SOBP), a spurious peak was observed due to the mismatch of distal edge between the calibration and measurement films. The width of SOBP and the proximal edge were both reproducible within a maximum of 5 mm; the distal edge was reproducible within 1 mm. At 5 cm depth, the

  18. Experimental support at proton--proton colliding beam facilities

    International Nuclear Information System (INIS)

    Potter, K.

    1977-01-01

    Proton--proton colliding beam facilities have a number of special features which increase the importance of support for experiments when compared to fixed target accelerators: (1) the laboratory system is very close to the center-of-mass system; this affects the geometry and general size of the experiments; (2) the primary p--p interaction is inaccessible, that is, it takes place in an ultrahigh vacuum chamber; and (3) the experiment detection system is necessarily inside the machine structure and becomes very closely linked to it in many respects. An overall picture is given of experimental support based on experience at the CERN ISR under the following headings: Experimental Areas, Scheduling, Intersection Vacuum Chambers, Machine Background, and Magnets for Experiments. The first two of these topics concern the requirements in space and time of an experiment, while the last three are all related to the close interaction between experiment and machine

  19. Impact of high energy high intensity proton beams on targets: Case studies for Super Proton Synchrotron and Large Hadron Collider

    Directory of Open Access Journals (Sweden)

    N. A. Tahir

    2012-05-01

    Full Text Available The Large Hadron Collider (LHC is designed to collide two proton beams with unprecedented particle energy of 7 TeV. Each beam comprises 2808 bunches and the separation between two neighboring bunches is 25 ns. The energy stored in each beam is 362 MJ, sufficient to melt 500 kg copper. Safety of operation is very important when working with such powerful beams. An accidental release of even a very small fraction of the beam energy can result in severe damage to the equipment. The machine protection system is essential to handle all types of possible accidental hazards; however, it is important to know about possible consequences of failures. One of the critical failure scenarios is when the entire beam is lost at a single point. In this paper we present detailed numerical simulations of the full impact of one LHC beam on a cylindrical solid carbon target. First, the energy deposition by the protons is calculated with the FLUKA code and this energy deposition is used in the BIG2 code to study the corresponding thermodynamic and the hydrodynamic response of the target that leads to a reduction in the density. The modified density distribution is used in FLUKA to calculate new energy loss distribution and the two codes are thus run iteratively. A suitable iteration step is considered to be the time interval during which the target density along the axis decreases by 15%–20%. Our simulations suggest that the full LHC proton beam penetrates up to 25 m in solid carbon whereas the range of the shower from a single proton in solid carbon is just about 3 m (hydrodynamic tunneling effect. It is planned to perform experiments at the experimental facility HiRadMat (High Radiation Materials at CERN using the proton beam from the Super Proton Synchrotron (SPS, to compare experimental results with the theoretical predictions. Therefore simulations of the response of a solid copper cylindrical target hit by the SPS beam were performed. The particle

  20. Impact of high energy high intensity proton beams on targets: Case studies for Super Proton Synchrotron and Large Hadron Collider

    Science.gov (United States)

    Tahir, N. A.; Sancho, J. Blanco; Shutov, A.; Schmidt, R.; Piriz, A. R.

    2012-05-01

    The Large Hadron Collider (LHC) is designed to collide two proton beams with unprecedented particle energy of 7 TeV. Each beam comprises 2808 bunches and the separation between two neighboring bunches is 25 ns. The energy stored in each beam is 362 MJ, sufficient to melt 500 kg copper. Safety of operation is very important when working with such powerful beams. An accidental release of even a very small fraction of the beam energy can result in severe damage to the equipment. The machine protection system is essential to handle all types of possible accidental hazards; however, it is important to know about possible consequences of failures. One of the critical failure scenarios is when the entire beam is lost at a single point. In this paper we present detailed numerical simulations of the full impact of one LHC beam on a cylindrical solid carbon target. First, the energy deposition by the protons is calculated with the FLUKA code and this energy deposition is used in the BIG2 code to study the corresponding thermodynamic and the hydrodynamic response of the target that leads to a reduction in the density. The modified density distribution is used in FLUKA to calculate new energy loss distribution and the two codes are thus run iteratively. A suitable iteration step is considered to be the time interval during which the target density along the axis decreases by 15%-20%. Our simulations suggest that the full LHC proton beam penetrates up to 25 m in solid carbon whereas the range of the shower from a single proton in solid carbon is just about 3 m (hydrodynamic tunneling effect). It is planned to perform experiments at the experimental facility HiRadMat (High Radiation Materials) at CERN using the proton beam from the Super Proton Synchrotron (SPS), to compare experimental results with the theoretical predictions. Therefore simulations of the response of a solid copper cylindrical target hit by the SPS beam were performed. The particle energy in the SPS beam is 440

  1. SU-E-T-470: Beam Performance of the Radiance 330 Proton Therapy System

    International Nuclear Information System (INIS)

    Nazaryan, H; Nazaryan, V; Wang, F; Flanz, J; Alexandrov, V

    2014-01-01

    Purpose: The ProTom Radiance 330 proton radiotherapy system is a fully functional, compact proton radiotherapy system that provides advanced proton delivery capabilities. It supports three-dimensional beam scanning with energy and intensity modulation. A series of measurements have been conducted to characterize the beam performance of the first installation of the system at the McLaren Proton Therapy Center in Flint, Michigan. These measurements were part of the technical commissioning of the system. Select measurements and results are presented. Methods: The Radiance 330 proton beam energy range is 70–250 MeV for treatment, and up to 330 MeV for proton tomography and radiography. Its 3-D scanning capability, together with a small beam emittance and momentum spread, provides a highly efficient beam delivery. During the technical commissioning, treatment plans were created to deliver uniform maps at various energies to perform Gamma Index analysis. EBT3 Gafchromic films were irradiated using the Planned irradiation maps. Bragg Peak chamber was used to test the dynamic range during a scan in one layer for high (250 MeV) and Low (70 MeV) energies. The maximum and minimum range, range adjustment and modulation, distal dose falloff (80%–20%), pencil beam spot size, spot placement accuracy were also measured. The accuracy testing included acquiring images, image registration, receiving correction vectors and applying the corrections to the robotic patient positioner. Results: Gamma Index analysis of the Treatment Planning System (TPS) data vs. Measured data showed more than 90% of points within (3%, 3mm) for the maps created by the TPS. At Isocenter Beam Size (One sigma) < 3mm at highest energy (250 MeV) in air. Beam delivery was within 0.6 mm of the intended target at the entrance and the exit of the beam, through the phantom. Conclusion: The Radiance 330 Beam Performance Measurements have confirmed that the system operates as designed with excellent clinical

  2. SU-E-T-470: Beam Performance of the Radiance 330 Proton Therapy System

    Energy Technology Data Exchange (ETDEWEB)

    Nazaryan, H; Nazaryan, V; Wang, F [ProTom International, Inc., Flower Mound, TX (United States); Flanz, J [Massachusetts General Hospital, Boston, MA (United States); Alexandrov, V [ZAO ProTom, Protvino, Moscow region (Russian Federation)

    2014-06-01

    Purpose: The ProTom Radiance 330 proton radiotherapy system is a fully functional, compact proton radiotherapy system that provides advanced proton delivery capabilities. It supports three-dimensional beam scanning with energy and intensity modulation. A series of measurements have been conducted to characterize the beam performance of the first installation of the system at the McLaren Proton Therapy Center in Flint, Michigan. These measurements were part of the technical commissioning of the system. Select measurements and results are presented. Methods: The Radiance 330 proton beam energy range is 70–250 MeV for treatment, and up to 330 MeV for proton tomography and radiography. Its 3-D scanning capability, together with a small beam emittance and momentum spread, provides a highly efficient beam delivery. During the technical commissioning, treatment plans were created to deliver uniform maps at various energies to perform Gamma Index analysis. EBT3 Gafchromic films were irradiated using the Planned irradiation maps. Bragg Peak chamber was used to test the dynamic range during a scan in one layer for high (250 MeV) and Low (70 MeV) energies. The maximum and minimum range, range adjustment and modulation, distal dose falloff (80%–20%), pencil beam spot size, spot placement accuracy were also measured. The accuracy testing included acquiring images, image registration, receiving correction vectors and applying the corrections to the robotic patient positioner. Results: Gamma Index analysis of the Treatment Planning System (TPS) data vs. Measured data showed more than 90% of points within (3%, 3mm) for the maps created by the TPS. At Isocenter Beam Size (One sigma) < 3mm at highest energy (250 MeV) in air. Beam delivery was within 0.6 mm of the intended target at the entrance and the exit of the beam, through the phantom. Conclusion: The Radiance 330 Beam Performance Measurements have confirmed that the system operates as designed with excellent clinical

  3. Characterization of the ELIMED Permanent Magnets Quadrupole system prototype with laser-driven proton beams

    Science.gov (United States)

    Schillaci, F.; Pommarel, L.; Romano, F.; Cuttone, G.; Costa, M.; Giove, D.; Maggiore, M.; Russo, A. D.; Scuderi, V.; Malka, V.; Vauzour, B.; Flacco, A.; Cirrone, G. A. P.

    2016-07-01

    Laser-based accelerators are gaining interest in recent years as an alternative to conventional machines [1]. In the actual ion acceleration scheme, energy and angular spread of the laser-driven beams are the main limiting factors for beam applications and different solutions for dedicated beam-transport lines have been proposed [2,3]. In this context a system of Permanent Magnet Quadrupoles (PMQs) has been realized [2] by INFN-LNS (Laboratori Nazionali del Sud of the Instituto Nazionale di Fisica Nucleare) researchers, in collaboration with SIGMAPHI company in France, to be used as a collection and pre-selection system for laser driven proton beams. This system is meant to be a prototype to a more performing one [3] to be installed at ELI-Beamlines for the collection of ions. The final system is designed for protons and carbons up to 60 MeV/u. In order to validate the design and the performances of this large bore, compact, high gradient magnetic system prototype an experimental campaign have been carried out, in collaboration with the group of the SAPHIR experimental facility at LOA (Laboratoire d'Optique Appliquée) in Paris using a 200 TW Ti:Sapphire laser system. During this campaign a deep study of the quadrupole system optics has been performed, comparing the results with the simulation codes used to determine the setup of the PMQ system and to track protons with realistic TNSA-like divergence and spectrum. Experimental and simulation results are good agreement, demonstrating the possibility to have a good control on the magnet optics. The procedure used during the experimental campaign and the most relevant results are reported here.

  4. Scintillator-CCD camera system light output response to dosimetry parameters for proton beam range measurement

    Energy Technology Data Exchange (ETDEWEB)

    Daftari, Inder K., E-mail: idaftari@radonc.ucsf.edu [Department of Radiation Oncology, 1600 Divisadero Street, Suite H1031, University of California-San Francisco, San Francisco, CA 94143 (United States); Castaneda, Carlos M.; Essert, Timothy [Crocker Nuclear Laboratory,1 Shields Avenue, University of California-Davis, Davis, CA 95616 (United States); Phillips, Theodore L.; Mishra, Kavita K. [Department of Radiation Oncology, 1600 Divisadero Street, Suite H1031, University of California-San Francisco, San Francisco, CA 94143 (United States)

    2012-09-11

    The purpose of this study is to investigate the luminescence light output response in a plastic scintillator irradiated by a 67.5 MeV proton beam using various dosimetry parameters. The relationship of the visible scintillator light with the beam current or dose rate, aperture size and the thickness of water in the water-column was studied. The images captured on a CCD camera system were used to determine optimal dosimetry parameters for measuring the range of a clinical proton beam. The method was developed as a simple quality assurance tool to measure the range of the proton beam and compare it to (a) measurements using two segmented ionization chambers and water column between them, and (b) with an ionization chamber (IC-18) measurements in water. We used a block of plastic scintillator that measured 5 Multiplication-Sign 5 Multiplication-Sign 5 cm{sup 3} to record visible light generated by a 67.5 MeV proton beam. A high-definition digital video camera Moticam 2300 connected to a PC via USB 2.0 communication channel was used to record images of scintillation luminescence. The brightness of the visible light was measured while changing beam current and aperture size. The results were analyzed to obtain the range and were compared with the Bragg peak measurements with an ionization chamber. The luminescence light from the scintillator increased linearly with the increase of proton beam current. The light output also increased linearly with aperture size. The relationship between the proton range in the scintillator and the thickness of the water column showed good linearity with a precision of 0.33 mm (SD) in proton range measurement. For the 67.5 MeV proton beam utilized, the optimal parameters for scintillator light output response were found to be 15 nA (16 Gy/min) and an aperture size of 15 mm with image integration time of 100 ms. The Bragg peak depth brightness distribution was compared with the depth dose distribution from ionization chamber measurements

  5. SU-E-T-610: Phosphor-Based Fiber Optic Probes for Proton Beam Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Darafsheh, A; Soldner, A; Liu, H; Kassaee, A; Zhu, T; Finlay, J [Univ Pennsylvania, Philadelphia, PA (United States)

    2015-06-15

    Purpose: To investigate feasibility of using fiber optics probes with rare-earth-based phosphor tips for proton beam radiation dosimetry. We designed and fabricated a fiber probe with submillimeter resolution (<0.5 mm3) based on TbF3 phosphors and evaluated its performance for measurement of proton beam including profiles and range. Methods: The fiber optic probe with TbF3 phosphor tip, embedded in tissue-mimicking phantoms was irradiated with double scattering proton beam with energy of 180 MeV. Luminescence spectroscopy was performed by a CCD-coupled spectrograph to analyze the emission spectra of the fiber tip. In order to measure the spatial beam profile and percentage depth dose, we used singular value decomposition method to spectrally separate the phosphors ionoluminescence signal from the background Cerenkov radiation signal. Results: The spectra of the TbF3 fiber probe showed characteristic ionoluminescence emission peaks at 489, 542, 586, and 620 nm. By using singular value decomposition we found the contribution of the ionoluminescence signal to measure the percentage depth dose in phantoms and compared that with measurements performed with ion chamber. We observed quenching effect at the spread out Bragg peak region, manifested as under-responding of the signal, due to the high LET of the beam. However, the beam profiles were not dramatically affected by the quenching effect. Conclusion: We have evaluated the performance of a fiber optic probe with submillimeter resolution for proton beam dosimetry. We demonstrated feasibility of spectral separation of the Cerenkov radiation from the collected signal. Such fiber probes can be used for measurements of proton beams profile and range. The experimental apparatus and spectroscopy method developed in this work provide a robust platform for characterization of proton-irradiated nanophosphor particles for ultralow fluence photodynamic therapy or molecular imaging applications.

  6. User control of the proton beam injection trajectories into the AGS Booster

    International Nuclear Information System (INIS)

    D'Ottavio, T.; Kponou, A.; Luccio, A.; Alessi, J.G.; Reece, R.K.; Skelly, J.

    1991-01-01

    The 1.5 GeV (proton) Booster Synchrotron nearing completion at the AGS will get its 200 MeV beam from the linac, via a 34.9 m long linac-to-Booster transport line, LTB. LTB branches off from the existing linac-to-AGS transport line, HEBT, approximately 18.4 m downstream from the linac. A schematic layout of LTB is shown in the bottom part of Fig. 1. The four dipoles, DH2 through DH5, which are identical and are operated in series, provide a 126 degrees bend in the line. We have employed three strategies for implementing control of the trajectory, namely: (1) a global correction (2) a local correction (3) a zeroing correction. These, as well as their implementation, will be discussed. Operating experience obtained from early commissioning runs will be given. The hardware used to implement the correction schemes are the beam position monitors, BPMxxx, orbit correctors, DHxxx and DVxxx, and multiwire profile monitors, MWxxx. The quads are QHxxx and QVxxx. 3 refs., 3 figs

  7. Pencil beam proton radiography using a multilayer ionization chamber

    NARCIS (Netherlands)

    Farace, Paolo; Righetto, Roberto; Meijers, Arturs

    2016-01-01

    A pencil beam proton radiography (PR) method, using a commercial multilayer ionization chamber (MLIC) integrated with a treatment planning system (TPS) was developed. A Giraffe (IBA Dosimetry) MLIC (+/- 0.5 mm accuracy) was used to obtain pencil beam PR by delivering spots uniformly positioned at a

  8. The Importance of Protons in Reactive Transport Modeling

    Science.gov (United States)

    McNeece, C. J.; Hesse, M. A.

    2014-12-01

    The importance of pH in aqueous chemistry is evident; yet, its role in reactive transport is complex. Consider a column flow experiment through silica glass beads. Take the column to be saturated and flowing with solution of a distinct pH. An instantaneous change in the influent solution pH can yield a breakthrough curve with both a rarefaction and shock component (composite wave). This behavior is unique among aqueous ions in transport and is more complex than intuition would tell. Analysis of the hyperbolic limit of this physical system can explain these first order transport phenomenon. This analysis shows that transport behavior is heavily dependent on the shape of the adsorption isotherm. Hence it is clear that accurate surface chemistry models are important in reactive transport. The proton adsorption isotherm has nonconstant concavity due to the proton's ability to partition into hydroxide. An eigenvalue analysis shows that an inflection point in the adsorption isotherm allows the development of composite waves. We use electrostatic surface complexation models to calculate realistic proton adsorption isotherms. Surface characteristics such as specific surface area, and surface site density were determined experimentally. We validate the model by comparison against silica glass bead flow through experiments. When coupled to surface complexation models, the transport equation captures the timing and behavior of breakthrough curves markedly better than with commonly used Langmuir assumptions. Furthermore, we use the adsorption isotherm to predict, a priori, the transport behavior of protons across pH composition space. Expansion of the model to multicomponent systems shows that proton adsorption can force composite waves to develop in the breakthrough curves of ions that would not otherwise exhibit such behavior. Given the abundance of reactive surfaces in nature and the nonlinearity of chemical systems, we conclude that building a greater understanding of

  9. Proton movement and coupling in the POT family of peptide transporters.

    Science.gov (United States)

    Parker, Joanne L; Li, Chenghan; Brinth, Allete; Wang, Zhi; Vogeley, Lutz; Solcan, Nicolae; Ledderboge-Vucinic, Gregory; Swanson, Jessica M J; Caffrey, Martin; Voth, Gregory A; Newstead, Simon

    2017-12-12

    POT transporters represent an evolutionarily well-conserved family of proton-coupled transport systems in biology. An unusual feature of the family is their ability to couple the transport of chemically diverse ligands to an inwardly directed proton electrochemical gradient. For example, in mammals, fungi, and bacteria they are predominantly peptide transporters, whereas in plants the family has diverged to recognize nitrate, plant defense compounds, and hormones. Although recent structural and biochemical studies have identified conserved sites of proton binding, the mechanism through which transport is coupled to proton movement remains enigmatic. Here we show that different POT transporters operate through distinct proton-coupled mechanisms through changes in the extracellular gate. A high-resolution crystal structure reveals the presence of ordered water molecules within the peptide binding site. Multiscale molecular dynamics simulations confirm proton transport occurs through these waters via Grotthuss shuttling and reveal that proton binding to the extracellular side of the transporter facilitates a reorientation from an inward- to outward-facing state. Together these results demonstrate that within the POT family multiple mechanisms of proton coupling have likely evolved in conjunction with variation of the extracellular gate. Copyright © 2017 the Author(s). Published by PNAS.

  10. Status report on a dc 130-mA, 75-keV proton injector

    International Nuclear Information System (INIS)

    Sherman, J.; Arvin, A.; Hodgkins, D.

    1997-01-01

    A 110-mA, 75-keV dc proton injector is being developed at Los Alamos. We use a microwave proton source coupled to a two solenoid, space-charge neutralized, low-energy beam transport (LEBT) system. The ion source produces 110-mA proton current at 75 keV using 600 - 800 W of 2.45 GHz input discharge power. Typical proton fraction is 85-90% of the total extracted ion current, and the rms normalized beam emittance after transport through a prototype 2.1 m LEBT is 0.20 (πmm-mrad). Beam space-charge neutralization is measured to be > 98% which enables the solenoid magnetic transport to successfully match the injector beam into a radio-frequency quadrupole (RFQ). Beam simulations indicate small emittance growth in the proposed 2.8 m low-energy demonstration accelerator (LEDA) LEBT. The LEBT also contains beam diagnostics, steering, and a beam deflector for variable duty factor and accelerator fast protect functions. The injector computer controls and reliability status are also discussed

  11. Reference dosimetry of proton pencil beams based on dose-area product: a proof of concept.

    Science.gov (United States)

    Gomà, Carles; Safai, Sairos; Vörös, Sándor

    2017-06-21

    This paper describes a novel approach to the reference dosimetry of proton pencil beams based on dose-area product ([Formula: see text]). It depicts the calibration of a large-diameter plane-parallel ionization chamber in terms of dose-area product in a 60 Co beam, the Monte Carlo calculation of beam quality correction factors-in terms of dose-area product-in proton beams, the Monte Carlo calculation of nuclear halo correction factors, and the experimental determination of [Formula: see text] of a single proton pencil beam. This new approach to reference dosimetry proves to be feasible, as it yields [Formula: see text] values in agreement with the standard and well-established approach of determining the absorbed dose to water at the centre of a broad homogeneous field generated by the superposition of regularly-spaced proton pencil beams.

  12. Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital-based clinical cyclotron

    International Nuclear Information System (INIS)

    Jones, Kevin C.; Solberg, Timothy D.; Avery, Stephen; Vander Stappen, François; Janssens, Guillaume; Prieels, Damien; Bawiec, Christopher R.; Lewin, Peter A.; Sehgal, Chandra M.

    2015-01-01

    Purpose: To measure the acoustic signal generated by a pulsed proton spill from a hospital-based clinical cyclotron. Methods: An electronic function generator modulated the IBA C230 isochronous cyclotron to create a pulsed proton beam. The acoustic emissions generated by the proton beam were measured in water using a hydrophone. The acoustic measurements were repeated with increasing proton current and increasing distance between detector and beam. Results: The cyclotron generated proton spills with rise times of 18 μs and a maximum measured instantaneous proton current of 790 nA. Acoustic emissions generated by the proton energy deposition were measured to be on the order of mPa. The origin of the acoustic wave was identified as the proton beam based on the correlation between acoustic emission arrival time and distance between the hydrophone and proton beam. The acoustic frequency spectrum peaked at 10 kHz, and the acoustic pressure amplitude increased monotonically with increasing proton current. Conclusions: The authors report the first observation of acoustic emissions generated by a proton beam from a hospital-based clinical cyclotron. When modulated by an electronic function generator, the cyclotron is capable of creating proton spills with fast rise times (18 μs) and high instantaneous currents (790 nA). Measurements of the proton-generated acoustic emissions in a clinical setting may provide a method for in vivo proton range verification and patient monitoring

  13. A proton beam delivery system for conformal therapy and intensity modulated therapy

    International Nuclear Information System (INIS)

    Yu Qingchang

    2001-01-01

    A scattering proton beam delivery system for conformal therapy and intensity modulated therapy is described. The beam is laterally spread out by a dual-ring double scattering system and collimated by a program-controlled multileaf collimator and patient specific fixed collimators. The proton range is adjusted and modulated by a program controlled binary filter and ridge filters

  14. Experimental characterization and physical modelling of the dose distribution of scanned proton pencil beams

    International Nuclear Information System (INIS)

    Pedroni, E; Scheib, S; Boehringer, T; Coray, A; Grossmann, M; Lin, S; Lomax, A

    2005-01-01

    In this paper we present the pencil beam dose model used for treatment planning at the PSI proton gantry, the only system presently applying proton therapy with a beam scanning technique. The scope of the paper is to give a general overview on the various components of the dose model, on the related measurements and on the practical parametrization of the results. The physical model estimates from first physical principles absolute dose normalized to the number of incident protons. The proton beam flux is measured in practice by plane-parallel ionization chambers (ICs) normalized to protons via Faraday-cup measurements. It is therefore possible to predict and deliver absolute dose directly from this model without other means. The dose predicted in this way agrees very well with the results obtained with ICs calibrated in a cobalt beam. Emphasis is given in this paper to the characterization of nuclear interaction effects, which play a significant role in the model and are the major source of uncertainty in the direct estimation of the absolute dose. Nuclear interactions attenuate the primary proton flux, they modify the shape of the depth-dose curve and produce a faint beam halo of secondary dose around the primary proton pencil beam in water. A very simple beam halo model has been developed and used at PSI to eliminate the systematic dependences of the dose observed as a function of the size of the target volume. We show typical results for the relative (using a CCD system) and absolute (using calibrated ICs) dosimetry, routinely applied for the verification of patient plans. With the dose model including the nuclear beam halo we can predict quite precisely the dose directly from treatment planning without renormalization measurements, independently of the dose, shape and size of the dose fields. This applies also to the complex non-homogeneous dose distributions required for the delivery of range-intensity-modulated proton therapy, a novel therapy technique

  15. Envelope model for passive magnetic focusing of an intense proton or ion beam propagating through thin foils

    Directory of Open Access Journals (Sweden)

    Steven M. Lund

    2013-04-01

    Full Text Available Ion beams (including protons with low emittance and high space-charge intensity can be propagated with normal incidence through a sequence of thin metallic foils separated by vacuum gaps of order the characteristic transverse beam extent to transport/collimate the beam or to focus it to a small transverse spot. Energetic ions have sufficient range to pass through a significant number of thin foils with little energy loss or scattering. The foils reduce the (defocusing radial electric self-field of the beam while not altering the (focusing azimuthal magnetic self-field of the beam, thereby allowing passive self-beam focusing if the magnetic field is sufficiently strong relative to the residual electric field. Here we present an envelope model developed to predict the strength of this passive (beam generated focusing effect under a number of simplifying assumptions including relatively long pulse duration. The envelope model provides a simple criterion for the necessary foil spacing for net focusing and clearly illustrates system focusing properties for either beam collimation (such as injecting a laser-produced proton beam into an accelerator or for magnetic pinch focusing to a small transverse spot (for beam driven heating of materials. An illustrative example is worked for an idealization of a recently performed laser-produced proton-beam experiment to provide guidance on possible beam focusing and collimation systems. It is found that foils spaced on the order of the characteristic transverse beam size desired can be employed and that envelope divergence of the initial beam entering the foil lens must be suppressed to limit the total number of foils required to practical values for pinch focusing. Relatively modest proton-beam current at 10 MeV kinetic energy can clearly demonstrate strong magnetic pinch focusing achieving a transverse rms extent similar to the foil spacing (20–50  μm gaps in beam propagation distances of tens of mm

  16. Radiosensitization by PARP inhibition to proton beam irradiation in cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Hirai, Takahisa [Department of Radiation Oncology, Juntendo University Faculty of Medicine, Bunkyo-ku, Tokyo (Japan); Division of Chemotherapy and Clinical Cancer Research, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan); Saito, Soichiro; Fujimori, Hiroaki [Division of Chemotherapy and Clinical Cancer Research, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan); Matsushita, Keiichiro; Nishio, Teiji [Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima-shi, Hiroshima (Japan); Okayasu, Ryuichi [International Open Laboratory, National Institute of Radiological Science, Chiba-shi, Chiba (Japan); Masutani, Mitsuko, E-mail: mmasutan@nagasaki-u.ac.jp [Division of Chemotherapy and Clinical Cancer Research, National Cancer Center Research Institute, Chuo-ku, Tokyo (Japan); Department of Frontier Life Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki (Japan)

    2016-09-09

    The poly(ADP-ribose) polymerase (PARP)-1 regulates DNA damage responses and promotes base excision repair. PARP inhibitors have been shown to enhance the cytotoxicity of ionizing radiation in various cancer cells and animal models. We have demonstrated that the PARP inhibitor (PARPi) AZD2281 is also an effective radiosensitizer for carbon-ion radiation; thus, we speculated that the PARPi could be applied to a wide therapeutic range of linear energy transfer (LET) radiation as a radiosensitizer. Institutes for biological experiments using proton beam are limited worldwide. This study was performed as a cooperative research at heavy ion medical accelerator in Chiba (HIMAC) in National Institute of Radiological Sciences. HIMAC can generate various ion beams; this enabled us to compare the radiosensitization effect of the PARPi on cells subjected to proton and carbon-ion beams from the same beam line. After physical optimization of proton beam irradiation, the radiosensitization effect of the PARPi was assessed in the human lung cancer cell line, A549, and the pancreatic cancer cell line, MIA PaCa-2. The effect of the PARPi, AZD2281, on radiosensitization to Bragg peak was more significant than that to entrance region. The PARPi increased the number of phosphorylated H2AX (γ-H2AX) foci and enhanced G2/M arrest after proton beam irradiation. This result supports our hypothesis that a PARPi could be applied to a wide therapeutic range of LET radiation by blocking the DNA repair response. - Highlights: • Effective radiosensitizers for particle radiation therapy have not been reported. • PARP inhibitor treatment radiosensitized after proton beam irradiation. • The sensitization at Bragg peak was greater than that at entrance region. • DSB induction and G2/M arrest is involved in the sensitization mechanism.

  17. Microfabrication of biocompatible hydrogels by proton beam writing

    Science.gov (United States)

    Nagasawa, Naotsugu; Kimura, Atsushi; Idesaki, Akira; Yamada, Naoto; Koka, Masashi; Satoh, Takahiro; Ishii, Yasuyuki; Taguchi, Mitsumasa

    2017-10-01

    Functionalization of biocompatible materials is expected to be widely applied in biomedical engineering and regenerative medicine fields. Hydrogel has been expected as a biocompatible scaffold which support to keep an organ shape during cell multiplying in regenerative medicine. Therefore, it is important to understanding a surface microstructure (minute shape, depth of flute) and a chemical characteristic of the hydrogel affecting the cell culture. Here, we investigate the microfabrication of biocompatible polymeric materials, such as the water-soluble polysaccharide derivatives hydroxypropyl cellulose and carboxymethyl cellulose, by use of proton beam writing (PBW). These polymeric materials were dissolved thoroughly in pure water using a planetary centrifugal mixer, and a sample sheet (1 mm thick) was formed on polyethylene terephthalate (PET) film. Crosslinking to form hydrogels was induced using a 3.0 MeV focused proton beam from the single-ended accelerator at Takasaki Ion Accelerators for Advanced Radiation Application. The aqueous samples were horizontally irradiated with the proton beam through the PET cover film, and then rinsed with deionized water. Microstructured hydrogels were obtained on the PET film using the PBW technique without toxic crosslinking reagents. Cell adhesion and proliferation on the microfabricated biocompatible hydrogels were investigated. Microfabrication of HPC and CMC by the use of PBW is expected to produce new biocompatible materials that can be applied in biological and medical applications.

  18. Preliminary results of an in-beam PET prototype for proton therapy

    International Nuclear Information System (INIS)

    Attanasi, F.; Belcari, N.; Camarda, M.; Cirrone, G.A.P.; Cuttone, G.; Del Guerra, A.; Di Rosa, F.; Lanconelli, N.; Rosso, V.; Russo, G.; Vecchio, S.

    2008-01-01

    Proton therapy can overcome the limitations of conventional radiotherapy due to the more selective energy deposition in depth and to the increased biological effectiveness. Verification of the delivered dose is desirable, but the complete stopping of the protons in patient prevents the application of electronic portal imaging methods that are used in conventional radiotherapy During proton therapy β + emitters like 11 C, 15 O, 10 C are generated in irradiated tissues by nuclear reactions. The measurement of the spatial distribution of this activity, immediately after patient irradiation, can lead to information on the effective delivered dose. First, results of a feasibility study of an in-beam PET for proton therapy are reported. The prototype is based on two planar heads with an active area of about 5x5 cm 2 . Each head is made up of a position sensitive photomultiplier coupled to a square matrix of same size of LYSO scintillating crystals (2x2x18 mm 3 pixel dimensions). Four signals from each head are acquired through a dedicated electronic board that performs signal amplification and digitization. A 3D reconstruction of the activity distribution is calculated using an expectation maximization algorithm. To characterize the PET prototype, the detection efficiency and the spatial resolution were measured using a point-like radioactive source. The validation of the prototype was performed using 62 MeV protons at the CATANA beam line of INFN LNS and PMMA phantoms. Using the full energy proton beam and various range shifters, a good correlation between the position of the activity distal edge and the thickness of the beam range shifter was found along the axial direction

  19. Preliminary results of an in-beam PET prototype for proton therapy

    Science.gov (United States)

    Attanasi, F.; Belcari, N.; Camarda, M.; Cirrone, G. A. P.; Cuttone, G.; Del Guerra, A.; Di Rosa, F.; Lanconelli, N.; Rosso, V.; Russo, G.; Vecchio, S.

    2008-06-01

    Proton therapy can overcome the limitations of conventional radiotherapy due to the more selective energy deposition in depth and to the increased biological effectiveness. Verification of the delivered dose is desirable, but the complete stopping of the protons in patient prevents the application of electronic portal imaging methods that are used in conventional radiotherapy During proton therapy β + emitters like 11C, 15O, 10C are generated in irradiated tissues by nuclear reactions. The measurement of the spatial distribution of this activity, immediately after patient irradiation, can lead to information on the effective delivered dose. First, results of a feasibility study of an in-beam PET for proton therapy are reported. The prototype is based on two planar heads with an active area of about 5×5 cm 2. Each head is made up of a position sensitive photomultiplier coupled to a square matrix of same size of LYSO scintillating crystals (2×2×18 mm 3 pixel dimensions). Four signals from each head are acquired through a dedicated electronic board that performs signal amplification and digitization. A 3D reconstruction of the activity distribution is calculated using an expectation maximization algorithm. To characterize the PET prototype, the detection efficiency and the spatial resolution were measured using a point-like radioactive source. The validation of the prototype was performed using 62 MeV protons at the CATANA beam line of INFN LNS and PMMA phantoms. Using the full energy proton beam and various range shifters, a good correlation between the position of the activity distal edge and the thickness of the beam range shifter was found along the axial direction.

  20. Preliminary results of an in-beam PET prototype for proton therapy

    Energy Technology Data Exchange (ETDEWEB)

    Attanasi, F.; Belcari, N.; Camarda, M. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy); Cirrone, G.A.P.; Cuttone, G. [INFN Laboratori Nazionali del Sud, Catania (Italy); Del Guerra, A. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy); Di Rosa, F. [INFN Laboratori Nazionali del Sud, Catania (Italy); Lanconelli, N. [Department of Physics, University of Bologna and INFN Sezione di Bologna, Bologna (Italy); Rosso, V. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy)], E-mail: valeria.rosso@pi.infn.it; Russo, G. [INFN Laboratori Nazionali del Sud, Catania (Italy); Vecchio, S. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy)

    2008-06-11

    Proton therapy can overcome the limitations of conventional radiotherapy due to the more selective energy deposition in depth and to the increased biological effectiveness. Verification of the delivered dose is desirable, but the complete stopping of the protons in patient prevents the application of electronic portal imaging methods that are used in conventional radiotherapy During proton therapy {beta}{sup +} emitters like {sup 11}C, {sup 15}O, {sup 10}C are generated in irradiated tissues by nuclear reactions. The measurement of the spatial distribution of this activity, immediately after patient irradiation, can lead to information on the effective delivered dose. First, results of a feasibility study of an in-beam PET for proton therapy are reported. The prototype is based on two planar heads with an active area of about 5x5 cm{sup 2}. Each head is made up of a position sensitive photomultiplier coupled to a square matrix of same size of LYSO scintillating crystals (2x2x18 mm{sup 3} pixel dimensions). Four signals from each head are acquired through a dedicated electronic board that performs signal amplification and digitization. A 3D reconstruction of the activity distribution is calculated using an expectation maximization algorithm. To characterize the PET prototype, the detection efficiency and the spatial resolution were measured using a point-like radioactive source. The validation of the prototype was performed using 62 MeV protons at the CATANA beam line of INFN LNS and PMMA phantoms. Using the full energy proton beam and various range shifters, a good correlation between the position of the activity distal edge and the thickness of the beam range shifter was found along the axial direction.

  1. Application of activity pencil beam algorithm using measured distribution data of positron emitter nuclei for therapeutic SOBP proton beam

    International Nuclear Information System (INIS)

    Miyatake, Aya; Nishio, Teiji

    2013-01-01

    Purpose: Recently, much research on imaging the clinical proton-irradiated volume using positron emitter nuclei based on target nuclear fragment reaction has been carried out. The purpose of this study is to develop an activity pencil beam (APB) algorithm for a simulation system for proton-activated positron-emitting imaging in clinical proton therapy using spread-out Bragg peak (SOBP) beams.Methods: The target nuclei of activity distribution calculations are 12 C nuclei, 16 O nuclei, and 40 Ca nuclei, which are the main elements in a human body. Depth activity distributions with SOBP beam irradiations were obtained from the material information of ridge filter (RF) and depth activity distributions of compounds of the three target nuclei measured by BOLPs-RGp (beam ON-LINE PET system mounted on a rotating gantry port) with mono-energetic Bragg peak (MONO) beam irradiations. The calculated data of depth activity distributions with SOBP beam irradiations were sorted in terms of kind of nucleus, energy of proton beam, SOBP width, and thickness of fine degrader (FD), which were verified. The calculated depth activity distributions with SOBP beam irradiations were compared with the measured ones. APB kernels were made from the calculated depth activity distributions with SOBP beam irradiations to construct a simulation system using the APB algorithm for SOBP beams.Results: The depth activity distributions were prepared using the material information of RF and the measured depth activity distributions with MONO beam irradiations for clinical therapy using SOBP beams. With the SOBP width widening, the distal fall-offs of depth activity distributions and the difference from the depth dose distributions were large. The shapes of the calculated depth activity distributions nearly agreed with those of the measured ones upon comparison between the two. The APB kernels of SOBP beams were prepared by making use of the data on depth activity distributions with SOBP beam

  2. Status of the anti-proton production beam in the CERN PS

    International Nuclear Information System (INIS)

    Cappi, R.; Evans, B.J.; Garoby, R.

    1990-01-01

    A new scheme was put into operation in November 1988 to upgrade the proton beam delivered by the 26 GeV Proton Synchrotron (PS) for anti-proton production. It makes use of quasi-adiabatic manipulations of the RF parameters to squeeze a beam filling 1/2 of the PS circumference into a 1/4 turn and can in theory preserve the longitudinal emittance. A maximum intensity of 1.68 e 13 ppp in 5 bunches at 26 GeV has been reached in the course of 22 weeks of operation. The limitations of the performance are analysed together with possible improvements. (author) 6 refs., 9 figs

  3. Treatment of the uterus cervix cancer with the JINR phasotron proton beam

    International Nuclear Information System (INIS)

    Astrakhan, B.V.; Kiseleva, V.N.; Pojdenko, V.K.; Klochkov, I.I.; Molokanov, A.G.; Mitsin, G.V.; Savchenko, O.V.; Zorin, V.P.

    1995-01-01

    The methods of the uterus cervix cancer proton-and-gamma treatment for the first time were elaborated in the CRC RAMS and ITEP in Moscow and then developed for the JINR proton beam in Dubna. The results of the clinical probation of the methods for the uterus cervix cancer treatment have confirmed the advantage of the proton irradiation. The most important advantage of the proton beam treatment is absence of postradiation reactions and complications in the critical organs (bladder and rectum). Up to now 31 patients with the uterus cervix cancer have been treated at the JINR phasotron. 6 of them had proton-and-gamma treatment combined with surgical operation and 22 patients received a radical proton-and-gamma treatment (without surgery). The clinical results are in good agreement with the preceding results of the ITEP group. After receiving proton-and-gamma radiotherapy of the uterus cervix, 83% of the patients are alive without recurrences, metastases and complications. 10 refs., 4 figs., 2 tabs

  4. Possibilities and conditions of applying PIXE analysis with external proton beam

    International Nuclear Information System (INIS)

    Potocek, V.

    1989-01-01

    The technical and methodological prerequisites are summed up for the use of the PIXE method with an external proton beam. The method is suitable for the preliminary analysis of unknown samples prior to the choice of the best suited analytical method, for the nondestructive analysis of rare samples such as unique works of art, of small amounts of materials which are difficult to access, etc., as well as for calibration and comparing analyses. As for the operators the application of the PIXE method with external proton beam assumes the availability of accelerator operating time, minimization of the length of exposure of the targets, optimization of parameters of the exciting beam and automation of the whole process. Attention is also devoted to technical provisions and organization of laboratory work. The design is described of an analytical unit using the PIXE method with external proton beam, and it is stated that the Van de Graaff accelerator at the Institute of Nuclear Physics in Rez near Prague could be used for the purpose. (Z.M.). 6 refs

  5. MEIC Proton Beam Formation with a Low Energy Linac

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yuhong [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)

    2015-09-01

    The MEIC proton and ion beams are generated, accumulated, accelerated and cooled in a new green-field ion injector complex designed specifically to support its high luminosity goal. This injector consists of sources, a linac and a small booster ring. In this paper we explore feasibility of a short ion linac that injects low-energy protons and ions into the booster ring.

  6. Warp simulations for capture and control of laser-accelerated proton beams

    International Nuclear Information System (INIS)

    Nuernberg, Frank; Harres, K; Roth, M; Friedman, A; Grote, D P; Logan, B G; Schollmeier, M

    2010-01-01

    The capture of laser-accelerated proton beams accompanied by co-moving electrons via a solenoid field has been studied with particle-in-cell simulations. The main advantages of the Warp simulation suite that we have used, relative to envelope or tracking codes, are the possibility of including all source parameters energy resolved, adding electrons as second species and considering the non-negligible space-charge forces and electrostatic self-fields. It was observed that the influence of the electrons is of vital importance. The magnetic effect on the electrons outbalances the space-charge force. Hence, the electrons are forced onto the beam axis and attract protons. Beside the energy dependent proton density increase on axis, the change in the particle spectrum is also important for future applications. Protons are accelerated/decelerated slightly, electrons highly. 2/3 of all electrons get lost directly at the source and 27% of all protons hit the inner wall of the solenoid.

  7. Response of a biological model to a proton beam in vivo

    International Nuclear Information System (INIS)

    Schuff, Juan A.; Burlon, Alejandro A.; Debray, Mario E.; Kesque, Jose M.; Kreiner, Andres J.; Stoliar, Pablo A.; Naab, Fabian; Ozafran, Mabel J.; Vazquez, Monica E.

    2000-01-01

    Wistar rats were locally irradiated with proton beams. By means of a plastic wedge used as an energy degradator of variable thickness, dorsal portions of skin were irradiated at several tissue depths. This model was used to perform proton irradiations with different doses in both the plateau and the Bragg portions of the Bragg curve. The particular geometry of the wedge, in which the maximum thickness is greater than the proton range, yields a portion of unaffected tissue included in the irradiated area. Thus, it was possible to obtain a reference zone contiguous to the affected area in the same animal. SSNTD were used to establish the spatial configuration and the dose of the proton beams. This methodology allows isodose curve calculations along the different tissue depths which are in agreement with the biologic effects observed. Additionally, the scattering of protons on the shielding material, that affects specific areas of the tissue, is detected by the SSNTD. (author)

  8. Warp simulations for capture and control of laser-accelerated proton beams

    International Nuclear Information System (INIS)

    Nurnberg, F.; Friedman, A.; Grote, D.P.; Harres, K.; Logan, B.G.; Schollmeier, M.; Roth, M.

    2009-01-01

    The capture of laser-accelerated proton beams accompanied by co-moving electrons via a solenoid field has been studied with particle-in-cell simulations. The main advantages of the Warp simulation suite that was used, relative to envelope or tracking codes, are the possibility of including all source parameters energy resolved, adding electrons as second species and considering the non-negligible space-charge forces and electrostatic self-fields. It was observed that the influence of the electrons is of vital importance. The magnetic effect on the electrons out balances the space-charge force. Hence, the electrons are forced onto the beam axis and attract protons. Besides the energy dependent proton density increase on axis, the change in the particle spectrum is also important for future applications. Protons are accelerated/decelerated slightly, electrons highly. 2/3 of all electrons get lost directly at the source and 27% of all protons hit the inner wall of the solenoid.

  9. Beam electron microprobe

    CERN Document Server

    Stoller, D; Muterspaugh, M W; Pollock, R E

    1999-01-01

    A beam profile monitor based on the deflection of a probe electron beam by the electric field of a stored, electron-cooled proton beam is described and first results are presented. Electrons were transported parallel to the proton beam by a uniform longitudinal magnetic field. The probe beam may be slowly scanned across the stored beam to determine its intensity, position, and size. Alternatively, it may be scanned rapidly over a narrow range within the interior of the stored beam for continuous observation of the changing central density during cooling. Examples of a two dimensional charge density profile obtained from a raster scan and of a cooling alignment study illustrate the scope of measurements made possible by this device.

  10. The optics of secondary polarized proton beams

    International Nuclear Information System (INIS)

    Carey, D.C.

    1990-05-01

    Polarized protons can be produced by the parity-violating decay of either lambda or sigma hyperons. A secondary bema of polarized protons can then be produced without the difficult procedure of accelerating polarized protons. The preservation of the polarization while the protons are being transmitted to a final focus places stringent limitations on the optics of the beam line. The equations of motion of a polarized particle in a magnetic field have been solved to first order for quadrupole and dipole magnets. The lowest order terms indicate that the polarization vector will be restored to its original direction upon passage through a magnetic system if the momentum vector is unaltered. Higher-order terms may be derived by an expansion in commutators of the rotation matrix and its longitudinal derivative. The higher-order polarization rotation terms then arise from the non-commutivity of the rotation matrices by large angles in three-dimensional space. 5 refs., 3 figs

  11. Hard X-ray bremsstrahlung production in solar flares by high-energy proton beams

    Science.gov (United States)

    Emslie, A. G.; Brown, J. C.

    1985-01-01

    The possibility that solar hard X-ray bremsstrahlung is produced by acceleration of stationary electrons by fast-moving protons, rather than vice versa, as commonly assumed, was investigated. It was found that a beam of protons which involves 1836 times fewer particles, each having an energy 1836 times greater than that of the electrons in the equivalent electron beam model, has exactly the same bremsstrahlung yield for a given target, i.e., the mechanism has an energetic efficiency equal to that of conventional bremsstrahlung models. Allowance for the different degrees of target ionization appropriate to the two models (for conventional flare geometries) makes the proton beam model more efficient than the electron beam model, by a factor of order three. The model places less stringent constraints than a conventional electron beam model on the flare energy release mechanism. It is also consistent with observed X-ray burst spectra, intensities, and directivities. The altitude distribution of hard X-rays predicted by the model agrees with observations only if nonvertical injection of the protons is assumed. The model is inconsistent with gamma-ray data in terms of conventional modeling.

  12. Proton Beam Fast Ignition Fusion: Synergy of Weibel and Rayleigh-Taylor Instabilities

    Science.gov (United States)

    Stefan, V. Alexander

    2011-04-01

    The proton beam generation and focusing in fast ignition inertial confinement fusion is studied. The spatial and energy spread of the proton beam generated in a laser-solid interaction is increased due to the synergy of Weibel and Rayleigh-Taylor instabilities. The focal spot radius can reach 100 μm, which is nearly an order of magnitude larger than the optimal value. The energy spread decreases the beam deposition energy in the focal spot. Under these conditions, ignition of a precompressed DT fuel is achieved with the beam powers much higher than the values presently in consideration. Work supported in part by NIKOLA TESLA Laboratories (Stefan University), La Jolla, CA.

  13. A critical study of emittance measurements of intense low-energy proton beams

    CERN Document Server

    Evans, Lyndon R

    1972-01-01

    The measurement of emittance in low energy proton beams suffers from two perturbing effects: 1) the neutralisation of the beam by backstreaming secondary electrons and 2) the space charge blowup of the beam sample between defining and analysing apparatus. An experimental study shows a significant change of the emittance orientation when bias is used to eliminate the secondary electrons. Biased and non-biased cases are also compared with computed dynamics including space charge. Criteria for the slit size and drift distance which make the space charge blow-up negligible are derived. In addition a transverse coherent oscillation of the proton beam, which was revealed the measurements, is discussed briefly. (11 refs).

  14. Dosimetric performance evaluation regarding proton beam incident angles of a lithium-based AB-BNCT design

    International Nuclear Information System (INIS)

    Lee, Pei-Yi; Jiang, Shiang-Huei; Liu, Yuan-Hao

    2014-01-01

    The 7 Li(p,xn) 7 Be nuclear reaction, based on the low-energy protons, could produce soft neutrons for accelerator-based boron neutron capture therapy (AB-BNCT). Based on the fact that the induced neutron field is relatively divergent, the relationship between the incident angle of proton beam and the neutron beam quality was evaluated in this study. To provide an intense epithermal neutron beam, a beam-shaping assembly (BSA) was designed. And a modified Snyder head phantom was used in the calculations for evaluating the dosimetric performance. From the calculated results, the intensity of epithermal neutrons increased with the increase in proton incident angle. Hence, either the irradiation time or the required proton current can be reduced. When the incident angle of 2.5-MeV proton beam is 120 deg., the required proton current is ∼13.3 mA for an irradiation time of half an hour. The results of this study show that the BSA designs can generate neutron beams with good intensity and penetrability. Using a 20-mA, 2.5-MeV proton beam as the source, the required irradiation time, to induce 60 RBE-Gy of maximum tumour dose, is less than half an hour in any proton beam alignments. On the premise that the dosimetric performances are similar, the intensity of epithermal neutrons can be increased by using non-collinear (e.g. 90 deg., 120 deg.) incident protons. Thus, either the irradiation time or the required proton current can be reduced. The use of 120 deg. BSA model shows the possibility to reduce the required proton current to ∼13.3 mA when the goal of irradiation time is 30 min. The decrease of required proton beam current certainly will make the use of lithium target much easier. In June 2013, a 5-MeV, 30-mA radio frequency quadruple (RFQ) accelerator for BNCT was built at INFN-LNL (Legnaro National Laboratories, Italy), which shows a possibility to build a suitable RFQ accelerator for the authors' design. In addition, a 2.5-MeV, 30-mA Tandem accelerator was

  15. Results of treatment of Icenko-Cushing disease with proton beam irradiation of the pituitary gland

    International Nuclear Information System (INIS)

    Marova, E.I.; Starkova, N.T.; Kirpatovskaya, L.E.; Kolesnikova, G.S.; Bukhman, A.I.; Rozhinskaya, L.Ya.; Bel'chenko, L.V.

    1987-01-01

    Proton beam therapy was given to 98 patients with Icenko-Cushing disease aged 15 to 40. Mild cases were treated by proton beam irradiation only while severe cases were managed using proton beam therapy combined with unilateral adrenalectomy or ortho-para-DDD. Catamnesis duration varied from 3 to 5 years. In most cases the exposure dose was 80-90 Gy (50-110 Gy). The procedure was well tolerated by all the patients. A dynamic multipolar converting method with 15-20 entrance poles in the left temporal area was employed (with the beam energy of 200 MeV). Stabilization of the course of disease and some clinical improvement were observed in most of the patients 3-4 months after proton beam therapy. In 6-36 months after irradiation 90% of the patients showed normal biochemical indices and the absence of any clinical signs of the disease. Thus the results of proton beam therapy of 98 patients with Icenko-Cushing disease after a follow-up of 3-5 years showed a high efficacy of this type of treatment. The method can be used alone or in combination with unilateral adrenalectomy as well as with oral administration of ortho-para-DDD

  16. Collimator scatter and 2D dosimetry in small proton beams

    NARCIS (Netherlands)

    van Luijk, P.; van 't Veld, A.A.; Zelle, H.D.; Schippers, J.M.

    Monte Carlo simulations have been performed to determine the influence of collimator-scattered protons from a 150 MeV proton beam on the dose distribution behind a collimator. Slit-shaped collimators with apertures between 2 and 20 mm have been simulated. The Monte Carlo code GEANT 3.21 has been

  17. Progress in the production of intense ion beams and the formation of proton layers

    International Nuclear Information System (INIS)

    Kapetanakos, C.A.; Golden, J.; Marsh, S.J.; Mahaffey, R.A.

    1977-01-01

    The results on ion sources and the application of ion beams to the formation of proton layers and rings are presented. Ion beams have been produced on three different generators. Some results from the experiments performed on the Gamble 2 generator are presented. The Gamble 2 generator with coaxial anode-cathode configuration, hollow beam cross-section produces power levels of 0.6-1.2 MV with peak ion current of 200 kA. The number of protons in the beam 4x10 16 . Peak ion currents is excess 200 kA, energy 1 MeV, ion current density 1 kA/cm 2 . Magnetic field configuration to provide formation of strong proton layers is shown

  18. Requirements of a proton beam accelerator for an accelerator-driven reactor

    International Nuclear Information System (INIS)

    Takahashi, H.; Zhao, Y.; Tsoupas, N.; An, Y.; Yamazaki, Y.

    1997-01-01

    When the authors first proposed an accelerator-driven reactor, the concept was opposed by physicists who had earlier used the accelerator for their physics experiments. This opposition arose because they had nuisance experiences in that the accelerator was not reliable, and very often disrupted their work as the accelerator shut down due to electric tripping. This paper discusses the requirements for the proton beam accelerator. It addresses how to solve the tripping problem and how to shape the proton beam

  19. Comparison of dose distribution for proton beams and electrons: advantages and disadvantages; Comparacao de distribuicao de dose para feixes de protons e eletrons: vantagens e desvantagens

    Energy Technology Data Exchange (ETDEWEB)

    Neto, Joao T.M.; Ferreira, Maira B.; Braga, Victor B. [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil)

    2016-07-01

    This study consists of a simulation of cancer therapy using a beam of protons and electrons. By comparing dose distribution curves for both beams we have showed the advantages and disadvantages of both therapies. The study was performed with Monte Carlo simulations using Geant4 code for a brain tumor, and it was found that the presence of the Bragg peak in proton beam allows a higher dose deposition in tumor and protection of adjacent tissues, while the electron beam has an entry dose in the tissue higher than the proton, yielding to the tissue neighbors of the tumor, unnecessary radiation. Moreover, it was also found significant production of neutrons from the proton beam, showing its main disadvantage. The continuation of this work will add the comparison with clinical beams of photons. (author)

  20. Spin flipping a stored polarized proton beam

    International Nuclear Information System (INIS)

    Caussyn, D.D.; Derbenev, Y.S.; Ellison, T.J.P.; Lee, S.Y.; Rinckel, T.; Schwandt, P.; Sperisen, F.; Stephenson, E.J.; von Przewoski, B.; Blinov, B.B.; Chu, C.M.; Courant, E.D.; Crandell, D.A.; Kaufman, W.A.; Krisch, A.D.; Nurushev, T.S.; Phelps, R.A.; Ratner, L.G.; Wong, V.K.; Ohmori, C.

    1994-01-01

    We recently studied the spin flipping of a vertically polarized, stored 139-MeV proton beam. To flip the spin, we induced an rf depolarizing resonance by sweeping our rf solenoid magnet's frequency through the resonance frequency. With multiple spin flips, we found a polarization loss of 0.0000±0.0005 per spin flip under the best conditions; this loss increased significantly for small changes in the conditions. Minimizing the depolarization during each spin flip is especially important because frequent spin flipping could significantly reduce the systematic errors in stored polarized-beam experiments

  1. Manipulation of laser-accelerated proton beam profiles by nanostructured and microstructured targets

    Directory of Open Access Journals (Sweden)

    L. Giuffrida

    2017-08-01

    Full Text Available Nanostructured and microstructured thin foils have been fabricated and used experimentally as targets to manipulate the spatial profile of proton bunches accelerated through the interaction with high intensity laser pulses (6×10^{19}  W/cm^{2}. Monolayers of polystyrene nanospheres were placed on the rear surfaces of thin plastic targets to improve the spatial homogeneity of the accelerated proton beams. Moreover, thin targets with grating structures of various configurations on their rear sides were used to modify the proton beam divergence. Experimental results are presented, discussed, and supported by 3D particle-in-cell numerical simulations.

  2. Use of a two-dimensional ionization chamber array for proton therapy beam quality assurance

    International Nuclear Information System (INIS)

    Arjomandy, Bijan; Sahoo, Narayan; Ding Xiaoning; Gillin, Michael

    2008-01-01

    Two-dimensional ion chamber arrays are primarily used for conventional and intensity modulated radiotherapy quality assurance. There is no commercial device of such type available on the market that is offered for proton therapy quality assurance. We have investigated suitability of the MatriXX, a commercial two-dimensional ion chamber array detector for proton therapy QA. This device is designed to be used for photon and electron therapy QA. The device is equipped with 32x32 parallel plate ion chambers, each with 4.5 mm diam and 7.62 mm center-to-center separation. A 250 MeV proton beam was used to calibrate the dose measured by this device. The water equivalent thickness of the buildup material was determined to be 3.9 mm using a 160 MeV proton beam. Proton beams of different energies were used to measure the reproducibility of dose output and to evaluate the consistency in the beam flatness and symmetry measured by MatriXX. The output measurement results were compared with the clinical commissioning beam data that were obtained using a 0.6 cc Farmer chamber. The agreement was consistently found to be within 1%. The profiles were compared with film dosimetry and also with ion chamber data in water with an excellent agreement. The device is found to be well suited for quality assurance of proton therapy beams. It provides fast two-dimensional dose distribution information in real time with the accuracy comparable to that of ion chamber measurements and film dosimetry

  3. Energy spectrum control for modulated proton beams

    International Nuclear Information System (INIS)

    Hsi, Wen C.; Moyers, Michael F.; Nichiporov, Dmitri; Anferov, Vladimir; Wolanski, Mark; Allgower, Chris E.; Farr, Jonathan B.; Mascia, Anthony E.; Schreuder, Andries N.

    2009-01-01

    In proton therapy delivered with range modulated beams, the energy spectrum of protons entering the delivery nozzle can affect the dose uniformity within the target region and the dose gradient around its periphery. For a cyclotron with a fixed extraction energy, a rangeshifter is used to change the energy but this produces increasing energy spreads for decreasing energies. This study investigated the magnitude of the effects of different energy spreads on dose uniformity and distal edge dose gradient and determined the limits for controlling the incident spectrum. A multilayer Faraday cup (MLFC) was calibrated against depth dose curves measured in water for nonmodulated beams with various incident spectra. Depth dose curves were measured in a water phantom and in a multilayer ionization chamber detector for modulated beams using different incident energy spreads. Some nozzle entrance energy spectra can produce unacceptable dose nonuniformities of up to ±21% over the modulated region. For modulated beams and small beam ranges, the width of the distal penumbra can vary by a factor of 2.5. When the energy spread was controlled within the defined limits, the dose nonuniformity was less than ±3%. To facilitate understanding of the results, the data were compared to the measured and Monte Carlo calculated data from a variable extraction energy synchrotron which has a narrow spectrum for all energies. Dose uniformity is only maintained within prescription limits when the energy spread is controlled. At low energies, a large spread can be beneficial for extending the energy range at which a single range modulator device can be used. An MLFC can be used as part of a feedback to provide specified energy spreads for different energies.

  4. Calculation of multi-dimensional dose distribution in medium due to proton beam incidence

    International Nuclear Information System (INIS)

    Kawachi, Kiyomitsu; Inada, Tetsuo

    1978-01-01

    The method of analyzing the multi-dimensional dose distribution in a medium due to proton beam incidence is presented to obtain the reliable and simplified method from clinical viewpoint, especially for the medical treatment of cancer. The heavy ion beam being taken out of an accelerator has to be adjusted to fit cancer location and size, utilizing a modified range modulator, a ridge filter, a bolus and a special scanning apparatus. The precise calculation of multi-dimensional dose distribution of proton beam is needed to fit treatment to a limit part. The analytical formulas consist of those for the fluence distribution in a medium, the divergence of flying range, the energy distribution itself, the dose distribution in side direction and the two-dimensional dose distribution. The fluence distribution in polystyrene in case of the protons with incident energy of 40 and 60 MeV, the energy distribution of protons at the position of a Bragg peak for various values of incident energy, the depth dose distribution in polystyrene in case of the protons with incident energy of 40 and 60 MeV and average energy of 100 MeV, the proton fluence and dose distribution as functions of depth for the incident average energy of 250 MeV, the statistically estimated percentage errors in the proton fluence and dose distribution, the estimated minimum detectable tumor thickness as a function of the number of incident protons for the different incident spectra with average energy of 250 MeV, the isodose distribution in a plane containing the central axis in case of the incident proton beam of 3 mm diameter and 40 MeV and so on are presented as the analytical results, and they are evaluated. (Nakai, Y.)

  5. Performance of a shallow-focus applied-magnetic-field diode for ion-beam-transport experiments

    Energy Technology Data Exchange (ETDEWEB)

    Young, F.C.; Neri, J.M.; Ottinger, P.F. [Naval Research Lab., Washington, DC (United States); Rose, D.V. [JAYCOR, Vienna (Vatican City State, Holy See); Jones, T.G.; Oliver, B.V.

    1997-12-31

    An applied-magnetic-field ion diode to study the transport of intense ion beams for light-ion inertial confinement fusion is being operated on the Gamble II generator at NRL. A Large-area (145-cm{sup 2}), shallow-focusing diode is used to provide the ion beam required for self-pinched transport (SPT) experiments. Experiments have demonstrated focusing at 70 cm for 1.2-MV, 40-kA protons. Beyond the focus, the beam hollows out consistent with 20--30 mrad microdivergence. The effect of the counter-pulse B-field on altering the ion-beam trajectories and improving the focus has been diagnosed with a multiple-pinhole-camera using radiachromic film. This diagnostic is also used to determine the radial and azimuthal uniformity of ion emission at the anode for different B-field conditions. Increasing the diode voltage to 1.5 MV and optimizing the ion current are planned before initiating SPT experiments. Experiments to measure the spatial beam profile at focus, i.e., the SPT channel entrance, are in progress. Results are presented.

  6. Proton-beam window design for a transmutation facility operating with a liquid lead target

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, C.; Lypsch, F.; Lizana, P. [Institute for Safety Research and Reactor Technology, Juelich (Germany)] [and others

    1995-10-01

    The proton beam target of an accelerator-driven transmutation facility can be designed as a vertical liquid lead column. To prevent lead vapor from entering the accelerator vacuum, a proton-beam window has to separate the area above the lead surface from the accelerator tube. Two radiation-cooled design alternatives have been investigated which should withstand a proton beam of 1.6 GeV and 25 mA. Temperature calculations based on energy deposition calculations with the Monte Carlo code HETC, stability analysis and spallation-induced damage calculations have been performed showing the applicability of both designs.

  7. Relative biological effectiveness (RBE) of proton beams in radiotherapy

    International Nuclear Information System (INIS)

    Calugaru, V.

    2011-01-01

    Treatment planning in proton therapy uses a generic value for the Relative Biological Efficiency (RBE) of 1.1 relative to 60 Co gamma-rays throughout the Spread Out Bragg Peak (SOBP). We have studied the variation of the RBE at three positions in the SOBP of the 76 and 201 MeV proton beams used for cancer treatment at the Institut Curie Proton Therapy in Orsay (ICPO) in two human tumor cell lines using clonogenic cell death and the incidence of DNA double-strand breaks (DSB) as measured by pulse-field gel electrophoresis without and with endonuclease treatment to reveal clustered lesions as endpoints.The RBE for induced cell killing by the 76 MeV beam increased with depth in the SOBP. However for the 201 MeV protons it was close to that for 137 Cs gamma-rays and did not vary significantly. The incidence of DSBs and clustered lesions was higher for protons than for 137 Cs g-rays, but did not depend on the proton energy or the position in the SOBP. In the second part of our work, we have shown using cell clones made deficient for known repair genes by stable or transient shRNA transfection, that the D-NHEJ pathway determine the response to protons. The response of DNA damages created in the distal part of the 76 MeV SOBP suggests that those damages belong to the class of DNA 'complex lesions' (LMDS). It also appears that the particle fluence is a major determinant of the outcome of treatment in the distal part of the SOBP. (author)

  8. Coherent production of {epsilon}{sup +} particles in crystal using proton beam from SSC

    Energy Technology Data Exchange (ETDEWEB)

    Okorokov, V.V.; Dubin, A.Yu. [ITER, Moscow, (Russian Federation)

    1995-05-01

    The unique possibilities of the SSC can be ideally used for a new generation of coherent generation experiments with relativistic protons which require 20 Tev energy of the incident beam. The availability of 20 Tev proton beam at SSC allows new experiments on coherent production of {var_epsilon}{sup +} particle by relativistic proton in crystal. Experiment carried out at low energies can now be extended with protons in very narrow energy region (resonance energy, which easy can be calculated) using the new accelerator facilities at SSC. We propose to study coherent production via the Coulomb field of the cristal atoms to excite the transition p + {gamma}{implies} {var_epsilon} {sup +} (1189).

  9. Measurement of proton-beam parameters by means of digital television diagnostic system

    International Nuclear Information System (INIS)

    Vazhenin, V.A.; Borovkov, S.D.; Evtikhiev, A.V.

    1992-01-01

    A method is described for measurement of the parameters of pulse-packet beams by means of a digital television diagnostic system. Results of tests of the system in measurement of the parameters of a proton beam with an energy of 1.35 GeV in the U-70 circular accelerator and results of measurements of the energy spectrum of the 30-MeV proton beam of the LU-30 linear accelerator are given. The possibility is shown of using the system to measure the integrated characteristics of an entire beam-pulse packet as well as the characteristics of individual pulses with a period of 60 msec. 6 refs., 4 figs., 1 tab

  10. Giant photoeffect in proton transport through graphene membranes

    Science.gov (United States)

    Lozada-Hidalgo, Marcelo; Zhang, Sheng; Hu, Sheng; Kravets, Vasyl G.; Rodriguez, Francisco J.; Berdyugin, Alexey; Grigorenko, Alexander; Geim, Andre K.

    2018-04-01

    Graphene has recently been shown to be permeable to thermal protons1, the nuclei of hydrogen atoms, which sparked interest in its use as a proton-conducting membrane in relevant technologies1-4. However, the influence of light on proton permeation remains unknown. Here we report that proton transport through Pt-nanoparticle-decorated graphene can be enhanced strongly by illuminating it with visible light. Using electrical measurements and mass spectrometry, we find a photoresponsivity of ˜104 A W-1, which translates into a gain of ˜104 protons per photon with response times in the microsecond range. These characteristics are competitive with those of state-of-the-art photodetectors that are based on electron transport using silicon and novel two-dimensional materials5-7. The photo-proton effect could be important for graphene's envisaged use in fuel cells and hydrogen isotope separation. Our observations may also be of interest for other applications such as light-induced water splitting, photocatalysis and novel photodetectors.

  11. Charge collection in an external proton beam

    International Nuclear Information System (INIS)

    Wookey, C.W.; Somswasdi, B.; Rouse, J.L.

    1982-01-01

    Results from the measurement of the stability of charge collected from the target and exit foil, or as alternatives, the γ-ray or backscattered proton counts from the exit foil and the Ar X-ray counts from the air path in an external proton beam are presented. These results show that comparative analysis of material mounted in air is reliable, using either the collected charge or the γ-ray counts as the normalizing factor, if there are no earthed objects in close geometry. The backscattered proton counts can also be used, but not the Ar X-ray counts, unless the current is stabilized. The electrical or thermal conductivity of the target and the target to exit foil separation do not affect the proportionality of the collected charge and the γ-ray counts to the charge incident on the target

  12. New beam instrumentation in the AGS Booster

    International Nuclear Information System (INIS)

    Witkover, R.L.

    1991-01-01

    The AGS Booster was designed to accelerate beams from 2x10 10 polarized protons to 1.5x10 13 protons and heavy ions through Au +33 . The range of beam parameters and the high vacuum, and radiation environment presented challenges for the beam instrumentation. Some interesting beam monitors in the Booster and transport lines, will be described. Where available, results will be presented. 21 refs., 7 figs

  13. Commissioning of polarized-proton and antiproton beams at Fermilab

    International Nuclear Information System (INIS)

    Yokosawa, A.

    1988-01-01

    The author described the polarized-proton and polarized-antiproton beams up to 200 GeV/c at Fermilab. The beam line, called MP, consists of the 400-m long primary and 350-m long secondary beam line followed by 60-m long experimental hall. We discuss the characteristics of the polarized beams. The Fermilab polarization projects are designated at E-581/704 initiated and carried out by an international collaboration, Argonne (US), Fermilab (US), Kyoto-Kyushu-Hiroshima-KEK (Japan), LAPP (France), Northwestern University (US), Los Alamos Laboratory (US), Rice (US), Saclay (France), Serpukhov (USSR), INFN Trieste (Italy), and University of Texas (US)

  14. Reactive transport of aqueous protons in porous media

    KAUST Repository

    McNeece, Colin J.

    2016-10-09

    The sorption of protons determines the surface charge of natural media and is therefore a first-order control on contaminant transport. Significant effort has been extended to develop chemical models that quantify the sorption of protons at the mineral surface. To compare these models’ effect on predicted proton transport, we present analytic solutions for column experiments through silica sand. Reaction front morphology is controlled by the functional relationship between the total sorbed and total aqueous proton concentrations. An inflection point in this function near neutral pH leads to a reversal in the classic front formation mechanism under basic conditions, such that proton desorption leads to a self-sharpening front, while adsorption leads to a spreading front. A composite reaction front comprising both a spreading and self-sharpening segment can occur when the injected and initial concentrations straddle the inflection point. This behavior is unique in single component reactive transport and arises due to the auto-ionization of water rather than electrostatic interactions at the mineral surface. We derive a regime diagram illustrating conditions under which different fronts occur, highlighting areas where model predictions diverge. Chemical models are then compared and validated against a systematic set of column experiments.

  15. Anti-angiogenic activity in metastasis of human breast cancer cells irradiated by a proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyu-Shik; Shin, Jin-Sun; Nam, Kyung-Soo [Dongguk University, Gyeongju (Korea, Republic of); Shon, Yun-Hee [Kyungpook National University Hospital, Daegu (Korea, Republic of)

    2012-07-15

    Angiogenesis is an essential process of metastasis in human breast cancer. We investigated the effects of proton beam irradiation on angiogenic enzyme activities and their expressions in MCF-7 human breast cancer cells. The regulation of angiogenic regulating factors, of transforming growth factor-β (TGF-β) and of vesicular endothelial growth factor (VEGF) expression in breast cancer cells irradiated with a proton beam was studied. Aromatase activity and mRNA expression, which is correlated with metastasis, were significantly decreased by irradiation with a proton beam in a dose-dependent manner. TGF-β and VEGF transcriptions were also diminished by proton beam irradiation. In contrast, transcription of tissue inhibitors of matrix metalloproteinases (TIMPs), also known as biological inhibitors of matrix metalloproteinases (MMPs), was dose-dependently enhanced. Furthermore, an increase in the expression of TIMPs caused the MMP-9 activity to be diminished and the MMP-9 and the MMP-2 expressions to be decreased. These results suggest that inhibition of angiogenesis by proton beam irradiation in breast cancer cells is closely related to inhibitions of aromatase activity and transcription and to down-regulation of TGF-β and VEGF transcription.

  16. Gas-breakdown effects associated with the self-pinched transport of intense light-ion beams

    International Nuclear Information System (INIS)

    Ottinger, P.F.; Olson, C.L.; Welch, D.R.; Oliver, B.V.

    1997-01-01

    Self-pinched transport (SPT) of intense light-ion beams is being considered for delivering energy to a high-gain, high-yield inertial confinement fusion target. Proton beam SPT experiments are underway on the Gamble II generators at the Naval Research Laboratory. The physics of SPT in low-pressure gas is being analyzed with analytic theory and numerical simulations. A 1-D theory estimates the net current fraction necessary for stable transport as a function of gas density for a given beam profile. SPT simulations using the 3-D hybrid particle-in-cell (PIC) code IPROP determine the beam profile. Important to both theory and simulations is the inclusion of gas-breakdown physics. A comparison between the theory and the self-consistent simulations using IPROP is made. Additional SPT simulations have been carried out using the 2-D hybrid PIC code SOLENZ which assumes a pre-ionized plasma. This simulation model enables the investigation of long time scale beam propagation issues. A comparison between IPROP and SOLENZ will be presented. SOLENZ simulations with the Gamble I beam parameters demonstrate SPT but point to the need to study the injection conditions to improve beam confinement. Simulations examining beam-to-wall distance and injection conditions will be presented

  17. The water equivalence of solid materials used for dosimetry with small proton beams

    International Nuclear Information System (INIS)

    Schneider, Uwe; Pemler, Peter; Besserer, Juergen; Dellert, Matthias; Moosburger, Martin; Boer, Jorrit de; Pedroni, Eros; Boehringer, Terence

    2002-01-01

    Various solid materials are used instead of water for absolute dosimetry with small proton beams. This may result in a dose measurement different to that in water, even when the range of protons in the phantom material is considered correctly. This dose difference is caused by the diverse cross sections for inelastic nuclear scattering in water and in the phantom materials respectively. To estimate the magnitude of this effect, flux and dose measurements with a 177 MeV proton pencil beam having a width of 0.6 cm (FWHM) were performed. The proton flux and the deposited dose in the beam path were determined behind water, lucite, polyethylene, teflon, and aluminum of diverse thicknesses. The number of out-scattered protons due to inelastic nuclear scattering was determined for water and the different materials. The ratios of the number of scattered protons in the materials relative to that in water were found to be 1.20 for lucite, 1.16 for polyethylene, 1.22 for teflon, and 1.03 for aluminum. The difference between the deposited dose in water and in the phantom materials taken in the center of the proton pencil beam, was estimated from the flux measurements, always taking the different ranges of protons in the materials into account. The estimated dose difference relative to water in 15 cm water equivalent thickness was -2.3% for lucite, -1.7% for polyethylene, -2.5% for teflon, and -0.4% for aluminum. The dose deviation was verified by a measurement using an ionization chamber. It should be noted that the dose error is larger when the effective point of measurement in the material is deeper or when the energy is higher

  18. CHARACTERIZATION OF 27 MEV PROTON BEAM GENERATED BY TOP-IMPLART LINEAR ACCELERATOR.

    Science.gov (United States)

    De Angelis, C; Ampollini, A; Basile, E; Cisbani, E; Della Monaca, S; Ghio, F; Montereali, R M; Picardi, L; Piccinini, M; Placido, C; Ronsivalle, C; Soriani, A; Strigari, L; Trinca, E; Vadrucci, M

    2018-01-29

    The first proton linear accelerator for tumor therapy based on an actively scanned beam up to the energy of 150 MeV, is under development and construction by ENEA-Frascati, ISS and IFO, under the Italian TOP-IMPLART project. Protons up to the energy of 7 MeV are generated by a customized commercial injector operating at 425 MHz; currently three accelerating modules allow proton delivery with energy up to 27 MeV. Beam homogeneity and reproducibility were studied using a 2D ionizing chamber, EBT3 films, a silicon diode, MOSFETs, LiF crystals and alanine dosimetry systems. Measurements were taken in air with the detectors at ~1 m from the beam line exit window. The maximum energy impinging on the detectors surface was 24.1 MeV, an energy suitable for radiobiological studies. Results showed beam reproducibility within 5% and homogeneity within 4%, on a circular surface of 16 mm in diameter. © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  19. Methodologies and tools for proton beam design for lung tumors

    International Nuclear Information System (INIS)

    Moyers, Michael F.; Miller, Daniel W.; Bush, David A.; Slater, Jerry D.

    2001-01-01

    Purpose: Proton beams can potentially increase the dose delivered to lung tumors without increasing the dose to critical normal tissues because protons can be stopped before encountering the normal tissues. This potential can only be realized if tissue motion and planning uncertainties are correctly included during planning. This study evaluated several planning strategies to determine which method best provides adequate tumor coverage, minimal normal tissue irradiation, and simplicity of use. Methods and Materials: Proton beam treatment plans were generated using one or more of three different planning strategies. These strategies included designing apertures and boluses to the PTV, apertures to the PTV and boluses to the CTV, and aperture and bolus to the CTV. Results: The planning target volume as specified in ICRU Report 50 can be used only to design the lateral margins of beams, because the distal and proximal margins resulting from CT number uncertainty, beam range uncertainty, tissue motions, and setup uncertainties, are different than the lateral margins resulting from these same factors. The best strategy for target coverage with the planning tools available overirradiated some normal tissues unnecessarily. The available tools also made the planning of lung tumors difficult. Conclusions: This study demonstrated that inclusion of target motion and setup uncertainties into a plan should be performed in the beam design step instead of creating new targets. New computerized treatment planning system tools suggested by this study will ease planning, facilitate abandonment of the PTV concept, improve conformance of the dose distribution to the target, and improve conformal avoidance of critical normal tissues

  20. PDMS patterning by proton beam

    International Nuclear Information System (INIS)

    Szilasi, S.Z.; Huszank, R.; Csik, A.; Rajta, I.; Cserhati, C.

    2008-01-01

    Complete text of publication follows. In this paper the poly-(dimethylsiloxane) (PDMS) is introduced as a resist material for proton beam writing. We were looking for a biocompatible micropatternable polymer in which the chemical structure changes significantly due to proton beam exposure making the polymer capable of proton beam writing. PDMS is a commonly used silicon-based organic polymer, optically clear, and generally considered to be inert, non-toxic biocompatible polymer. PDMS is also notably hydrophobic, meaning that water cannot easily penetrate its surface. This property has led extended use of PDMS in microfluidics too. PDMS is a crosslinkable polymer, it acts like a rubbery solid when it is cross-linked. In this state, the polymer does not deform permanently under stress or strain. Up to now the PDMS has been used as a casting or replicating material in microfabrication to form microchannels, micromolding, or creating microstamps, etc. PDMS has not been used as a resist material for direct write techniques. In this work we investigated the surface topography of the irradiated regions of PDMS under and without stress (on the cut surface and on the original fluid surface, respectively). In the samples wherein stress was not developed, noticeable compaction was observed. In case of those samples wherein stress was developed, noticeable swelling occurred. During the irradiation around the actual position of the beam spot we experienced significant swelling that reduced in time. To determine the large scale remaining changes in the surface topography at the cut edges of the samples we used Scanning Electron Microscope (SEM). After numerous profilometer measurements we experienced that the irradiated areas became harder, so the probe could move on it without sinking. The unirradiated areas of the PDMS were so soft, that the probe sank in the medium even with the smallest load (5 x 10 -7 N). Because of this phenomenon the irradiated areas seem to be higher

  1. Comparison of the secondary electrons produced by proton and electron beams in water

    Energy Technology Data Exchange (ETDEWEB)

    Kia, Mohammad Reza, E-mail: m-r-kia@aut.ac.ir; Noshad, Houshyar [Department of Energy Engineering and Physics, Amirkabir University of Technology (Tehran Polytechnic), P.O. Box 15875-4413, Hafez Avenue, Tehran (Iran, Islamic Republic of)

    2016-05-15

    The secondary electrons produced in water by electron and proton beams are compared with each other. The total ionization cross section (TICS) for an electron impact in water is obtained by using the binary-encounter-Bethe model. Hence, an empirical equation based on two adjustable fitting parameters is presented to determine the TICS for proton impact in media. In order to calculate the projectile trajectory, a set of stochastic differential equations based on the inelastic collision, elastic scattering, and bremsstrahlung emission are used. In accordance with the projectile trajectory, the depth dose deposition, electron energy loss distribution in a certain depth, and secondary electrons produced in water are calculated. The obtained results for the depth dose deposition and energy loss distribution in certain depth for electron and proton beams with various incident energies in media are in excellent agreement with the reported experimental data. The difference between the profiles for the depth dose deposition and production of secondary electrons for a proton beam can be ignored approximately. But, these profiles for an electron beam are completely different due to the effect of elastic scattering on electron trajectory.

  2. Beam control and matching for the transport of intense beams

    International Nuclear Information System (INIS)

    Li, H.; Bernal, S.; Godlove, T.; Huo, Y.; Kishek, R.A.; Haber, I.; Quinn, B.; Walter, M.; Zou, Y.; Reiser, M.; O'Shea, P.G.

    2005-01-01

    The transport of intense beams for heavy-ion inertial fusion demands tight control of beam characteristics from the source to the target. The University of Maryland Electron Ring (UMER), which uses a low-energy (10 keV), high-current electron beam to model the transport physics of a future recirculator driver, employs real-time beam characterization and control in order to optimize beam quality throughout the strong focusing lattice. We describe the main components and operation of the diagnostics/control system in UMER. It employs phosphor screens, real-time image analysis, quadrupole scans and electronic skew correctors. The procedure is not only indispensable for optimum transport over a long distance, but also provides important insights into the beam physics involved. We discuss control/optimization issues related to beam steering, quadrupole rotation errors and rms envelope matching

  3. Proton beam therapy control system

    Science.gov (United States)

    Baumann, Michael A [Riverside, CA; Beloussov, Alexandre V [Bernardino, CA; Bakir, Julide [Alta Loma, CA; Armon, Deganit [Redlands, CA; Olsen, Howard B [Colton, CA; Salem, Dana [Riverside, CA

    2008-07-08

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  4. Proton transport in a membrane protein channel: two-dimensional infrared spectrum modeling.

    NARCIS (Netherlands)

    Liang, C.; Knoester, J.; Jansen, T.L.Th.A.

    2012-01-01

    We model the two-dimensional infrared (2DIR) spectrum of a proton channel to investigate its applicability as a spectroscopy tool to study the proton transport process in biological systems. Proton transport processes in proton channels are involved in numerous fundamental biochemical reactions.

  5. New beam instrumentation in the AGS Booster

    Energy Technology Data Exchange (ETDEWEB)

    Witkover, R.L.

    1991-01-01

    The AGS Booster was designed to accelerate beams from 2{times}10{sup 10} polarized protons to 1.5{times}10{sup 13} protons and heavy ions through Au{sup +33}. The range of beam parameters and the high vacuum, and radiation environment presented challenges for the beam instrumentation. Some interesting beam monitors in the Booster and transport lines, will be described. Where available, results will be presented. 21 refs., 7 figs.

  6. Gene Expression Profile of Proton Beam Irradiated Breast Cancer Stem Cells

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Myung Hwan; Park, Jeong Chan [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    Cancer stem cells (CSCs) possess characteristics associated with normal stem cells. The mechanisms regulating CSC radio-resistance, including to proton beam, remain unclear. They showed that a subset of cells expressing CD44 with weak or no CD24 expression could establish new tumors in xenograft mice. Recently, BCSC-targeting therapies have been evaluated by numerous groups. Strategies include targeting BCSC self-renewal, indirectly targeting the microenvironment, and directly killing BCSCs by chemical agents that induce differentiation, immunotherapy, and oncolytic viruses. However, the mechanisms regulating CSC radio-resistance, particularly proton beam resistance, remain unclear. The identification of CSC-related gene expression patterns would make up offer data for better understanding CSCs properties. In this study we investigated the gene expression profile of BCSCs isolation from MCF-7 cell line. Reducing BCSC resistance to pulsed proton beams is essential to improve therapeutic efficacy and decrease the 5-year recurrence rate. In this respect, the information of the level of gene expression patterns in BCSCs is attractive for understanding molecular mechanisms of radio-resistance of BCSCs.

  7. Water equivalence of some plastic-water phantom materials for clinical proton beam dosimetry

    International Nuclear Information System (INIS)

    Al-Sulaiti, L.; Shipley, D.; Thomas, R.; Owen, P.; Kacperek, A.; Regan, P.H.; Palmans, H.

    2012-01-01

    Plastic-water phantom materials are not exactly water equivalent since they have a different elemental composition and different interaction cross sections for protons than water. Several studies of the water equivalence of plastic-water phantom materials have been reported for photon and electron beams, but none for clinical proton beams. In proton beams, the difference between non-elastic nuclear interactions in plastic-water phantom materials compared to those in water should be considered. In this work, the water equivalence of Plastic Water ® (PW) 1 , Plastic Water ® Diagnostic Therapy (PWDT) 1 and solid water (WT1) 2 phantoms was studied for clinical proton energies of 60 MeV and 200 MeV. This was done by evaluating the fluence correction factor at equivalent depths; first with respect to water and then with respect to graphite by experiment and Monte Carlo (MC) simulations using FLUKA. MC simulations showed that the fluence correction with respect to water was less than 0.5% up to the entire penetration depth of the protons at 60 MeV and less than 1% at 200 MeV up to 20 cm depth for PWDT, PW and WT1. With respect to graphite the fluence correction was about 0.5% for 60 MeV and about 4% for 200 MeV. The experimental results for modulated and un-modulated 60 MeV proton beams showed good agreement with the MC simulated fluence correction factors with respect to graphite deviating less than 1% from unity for the three plastic-water phantoms. - Highlights: ► We study plastic-water in clinical proton beams by experiment and Monte Carlo. ► We obtain fluence correction factors for water and graphite. ► The correction factor for water was close to 1 at 60 MeV and <0.990 at 200 MeV. ► The correction factor for graphite was ∼0.5% at 60 MeV and up to 4% at 200 MeV.

  8. Treatment planning, optimization, and beam delivery technqiues for intensity modulated proton therapy

    Science.gov (United States)

    Sengbusch, Evan R.

    Physical properties of proton interactions in matter give them a theoretical advantage over photons in radiation therapy for cancer treatment, but they are seldom used relative to photons. The primary barriers to wider acceptance of proton therapy are the technical feasibility, size, and price of proton therapy systems. Several aspects of the proton therapy landscape are investigated, and new techniques for treatment planning, optimization, and beam delivery are presented. The results of these investigations suggest a means by which proton therapy can be delivered more efficiently, effectively, and to a much larger proportion of eligible patients. An analysis of the existing proton therapy market was performed. Personal interviews with over 30 radiation oncology leaders were conducted with regard to the current and future use of proton therapy. In addition, global proton therapy market projections are presented. The results of these investigations serve as motivation and guidance for the subsequent development of treatment system designs and treatment planning, optimization, and beam delivery methods. A major factor impacting the size and cost of proton treatment systems is the maximum energy of the accelerator. Historically, 250 MeV has been the accepted value, but there is minimal quantitative evidence in the literature that supports this standard. A retrospective study of 100 patients is presented that quantifies the maximum proton kinetic energy requirements for cancer treatment, and the impact of those results with regard to treatment system size, cost, and neutron production is discussed. This study is subsequently expanded to include 100 cranial stereotactic radiosurgery (SRS) patients, and the results are discussed in the context of a proposed dedicated proton SRS treatment system. Finally, novel proton therapy optimization and delivery techniques are presented. Algorithms are developed that optimize treatment plans over beam angle, spot size, spot spacing

  9. Tests of SEC stability in high flux proton beams

    International Nuclear Information System (INIS)

    Agoritsas, V.; Witkover, R.L.

    1979-01-01

    The Secondary Emission Chamber (SEC) is used to measure the beam intensity in slow extracted beam channels of proton synchrotrons around the world. With the improvements in machine intensity, these monitors have been exposed to higher flux conditions than in the past. A change in sensitivity of up to 25% has been observed in the region around the beam spot. Using SEC's of special construction, a series of tests was performed at FNAL, BNL-AGS and CERN-PS. The results of these tests and conclusions about the construction of more stable SEC's are presented

  10. Technical Note: Spot characteristic stability for proton pencil beam scanning.

    Science.gov (United States)

    Chen, Chin-Cheng; Chang, Chang; Moyers, Michael F; Gao, Mingcheng; Mah, Dennis

    2016-02-01

    The spot characteristics for proton pencil beam scanning (PBS) were measured and analyzed over a 16 month period, which included one major site configuration update and six cyclotron interventions. The results provide a reference to establish the quality assurance (QA) frequency and tolerance for proton pencil beam scanning. A simple treatment plan was generated to produce an asymmetric 9-spot pattern distributed throughout a field of 16 × 18 cm for each of 18 proton energies (100.0-226.0 MeV). The delivered fluence distribution in air was measured using a phosphor screen based CCD camera at three planes perpendicular to the beam line axis (x-ray imaging isocenter and up/down stream 15.0 cm). The measured fluence distributions for each energy were analyzed using in-house programs which calculated the spot sizes and positional deviations of the Gaussian shaped spots. Compared to the spot characteristic data installed into the treatment planning system, the 16-month averaged deviations of the measured spot sizes at the isocenter plane were 2.30% and 1.38% in the IEC gantry x and y directions, respectively. The maximum deviation was 12.87% while the minimum deviation was 0.003%, both at the upstream plane. After the collinearity of the proton and x-ray imaging system isocenters was optimized, the positional deviations of the spots were all within 1.5 mm for all three planes. During the site configuration update, spot positions were found to deviate by 6 mm until the tuning parameters file was properly restored. For this beam delivery system, it is recommended to perform a spot size and position check at least monthly and any time after a database update or cyclotron intervention occurs. A spot size deviation tolerance of spot positions were <2 mm at any plane up/down stream 15 cm from the isocenter.

  11. Two-dimensional pencil beam scaling: an improved proton dose algorithm for heterogeneous media

    International Nuclear Information System (INIS)

    Szymanowski, Hanitra; Oelfke, Uwe

    2002-01-01

    New dose delivery techniques with proton beams, such as beam spot scanning or raster scanning, require fast and accurate dose algorithms which can be applied for treatment plan optimization in clinically acceptable timescales. The clinically required accuracy is particularly difficult to achieve for the irradiation of complex, heterogeneous regions of the patient's anatomy. Currently applied fast pencil beam dose calculations based on the standard inhomogeneity correction of pathlength scaling often cannot provide the accuracy required for clinically acceptable dose distributions. This could be achieved with sophisticated Monte Carlo simulations which are still unacceptably time consuming for use as dose engines in optimization calculations. We therefore present a new algorithm for proton dose calculations which aims to resolve the inherent problem between calculation speed and required clinical accuracy. First, a detailed derivation of the new concept, which is based on an additional scaling of the lateral proton fluence is provided. Then, the newly devised two-dimensional (2D) scaling method is tested for various geometries of different phantom materials. These include standard biological tissues such as bone, muscle and fat as well as air. A detailed comparison of the new 2D pencil beam scaling with the current standard pencil beam approach and Monte Carlo simulations, performed with GEANT, is presented. It was found that the new concept proposed allows calculation of absorbed dose with an accuracy almost equal to that achievable with Monte Carlo simulations while requiring only modestly increased calculation times in comparison to the standard pencil beam approach. It is believed that this new proton dose algorithm has the potential to significantly improve the treatment planning outcome for many clinical cases encountered in highly conformal proton therapy. (author)

  12. LHC Abort Gap Filling by Proton Beam

    CERN Document Server

    Fartoukh, Stéphane David; Shaposhnikova, Elena

    2004-01-01

    Safe operation of the LHC beam dump relies on the possibility of firing the abort kicker at any moment during beam operation. One of the necessary conditions for this is that the number of particles in the abort gap should be below some critical level defined by quench limits. Various scenarios can lead to particles filling the abort gap. Time scales associated with these scenarios are estimated for injection energy and also coast where synchrotron radiation losses are not negligible for uncaptured particle motion. Two cases are considered, with RF on and RF off. The equilibrium distribution of lost particles in the abort gap defines the requirements for maximum tolerable relative loss rate and as a consequence the minimum acceptable longitudinal lifetime of the proton beam in collision.

  13. SU-D-BRC-01: An Automatic Beam Model Commissioning Method for Monte Carlo Simulations in Pencil-Beam Scanning Proton Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Qin, N; Shen, C; Tian, Z; Jiang, S; Jia, X [UT Southwestern Medical Ctr, Dallas, TX (United States)

    2016-06-15

    Purpose: Monte Carlo (MC) simulation is typically regarded as the most accurate dose calculation method for proton therapy. Yet for real clinical cases, the overall accuracy also depends on that of the MC beam model. Commissioning a beam model to faithfully represent a real beam requires finely tuning a set of model parameters, which could be tedious given the large number of pencil beams to commmission. This abstract reports an automatic beam-model commissioning method for pencil-beam scanning proton therapy via an optimization approach. Methods: We modeled a real pencil beam with energy and spatial spread following Gaussian distributions. Mean energy, and energy and spatial spread are model parameters. To commission against a real beam, we first performed MC simulations to calculate dose distributions of a set of ideal (monoenergetic, zero-size) pencil beams. Dose distribution for a real pencil beam is hence linear superposition of doses for those ideal pencil beams with weights in the Gaussian form. We formulated the commissioning task as an optimization problem, such that the calculated central axis depth dose and lateral profiles at several depths match corresponding measurements. An iterative algorithm combining conjugate gradient method and parameter fitting was employed to solve the optimization problem. We validated our method in simulation studies. Results: We calculated dose distributions for three real pencil beams with nominal energies 83, 147 and 199 MeV using realistic beam parameters. These data were regarded as measurements and used for commission. After commissioning, average difference in energy and beam spread between determined values and ground truth were 4.6% and 0.2%. With the commissioned model, we recomputed dose. Mean dose differences from measurements were 0.64%, 0.20% and 0.25%. Conclusion: The developed automatic MC beam-model commissioning method for pencil-beam scanning proton therapy can determine beam model parameters with

  14. Dense monoenergetic proton beams from chirped laser-plasma interaction

    Energy Technology Data Exchange (ETDEWEB)

    Galow, Benjamin J.; Keitel, Christoph H. [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, Heidelberg (Germany); Salamin, Yousef I. [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, Heidelberg (Germany); Department of Physics, American University of Sharjah, POB 26666, Sharjah (United Arab Emirates); Liseykina, Tatyana V. [Institut fuer Physik, Universitaet Rostock, 18051 Rostock (Germany); Harman, Zoltan [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, Heidelberg (Germany); ExtreMe Matter Institute EMMI, Planckstrasse 1, 64291 Darmstadt (Germany)

    2012-07-01

    Interaction of a frequency-chirped laser pulse with single protons and a hydrogen gas target is studied analytically and by means of particle-in-cell simulations, respectively. Feasibility of generating ultra-intense (10{sup 7} particles per bunch) and phase-space collimated beams of protons (energy spread of about 1%) is demonstrated. Phase synchronization of the protons and the laser field, guaranteed by the appropriate chirping of the laser pulse, allows the particles to gain sufficient kinetic energy (around 250 MeV) required for such applications as hadron cancer therapy, from state-of-the-art laser systems of intensities of the order of 10{sup 21} W/cm{sup 2}.

  15. Dense monoenergetic proton beams from chirped laser-plasma interaction

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jianxing; Galow, Benjamin J.; Keitel, Christoph H. [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, Heidelberg (Germany); Salamin, Yousef I. [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, Heidelberg (Germany); Department of Physics, American University of Sharjah, POB 26666, Sharjah (United Arab Emirates); Harman, Zoltan [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, Heidelberg (Germany); ExtreMe Matter Institute EMMI, Planckstrasse 1, 64291 Darmstadt (Germany)

    2013-07-01

    Interactions of linearly and radially polarized frequency-chirped laser pulses with single protons and hydrogen gas targets are studied analytically and by means of particle-in-cell simulations, respectively. The feasibility of generating ultra-intense (10{sup 7} particles per bunch) and phase-space collimated beams of protons is demonstrated. Phase synchronization of the protons and the laser field, guaranteed by the appropriate chirping of the laser pulse, allows the particles to gain sufficient kinetic energy (around 250 MeV) required for such applications as hadron cancer therapy, from state-of-the-art laser systems of intensities of the order of 10{sup 21} W/cm{sup 2}.

  16. Suitability of some common polymer films for MeV proton beam dosimetry

    International Nuclear Information System (INIS)

    Makkonen-Craig, S.; Paronen, M.; Arstila, K.; Helariutta, K.; Rauhala, E.; Tikkanen, P.

    2005-01-01

    We have been evaluating the efficacy of polymer films for proton beam dosimetry. PE, PS, PVF, PVDF, PFA and FEP films were irradiated with 4.1 and 9.4 MeV protons at a flux of 2.5 x 10 11 cm -2 s -1 and a fluence of 2.5 x 10 13 cm -2 . The perfluorinated films were relatively insensitive to the proton irradiation. The UV absorption of PS displayed significant radiation-induced red shift, but no quantifiable absorption peaks. The strongly absorbing chromophore at 225 nm of irradiated PVDF is too unstable for practical dosimetry. PE has a stable and moderately absorbing radiolytic chromophore at 235 nm, but is transparent in the visible wavelength region. Irradiated PVF absorbs strongly in both UV and visible regions, and its UV absorbance is linearly proportional to the dose over the range of 10-1000 kGy when irradiated with 4.1 MeV protons at a dose rate of 840 Gy s -1 . PVF shows the most potential as multipurpose dosimeter for high resolution profiling of ion beams. Pertinent applications include irradiations that require verification of lateral beam homogeneity

  17. Analysis of target implosion irradiated by proton beam, (1)

    International Nuclear Information System (INIS)

    Tamba, Moritake; Nagata, Norimasa; Kawata, Shigeo; Niu, Keishiro.

    1982-10-01

    Numerical simulation and analysis were performed for the implosion of a hollow shell target driven by proton beam. The target consists of three layers of Pb, Al and DT. As the Al layer is heated by proton beam, the layer expands and pushes the DT layer toward the target center. To obtain the optimal velocity of DT implosion, the optimal target size and optimal layer thickness were determined. The target size is determined by, for example, the instability of the implosion or beam focusing on the target surface. The Rayleigh-Taylor instability and the unstable implosion due to the inhomogeneity were investigated. Dissipation, nonlinear effects and density gradient at the boundary were expected to reduce the growth rate of the Rayleigh-Taylor instability during the implosion. In order that the deviation of the boundary surface during the implosion is less than the thickness of fuel, the inhomogeneity of the temperature and the density of the target should be less than ten percent. The amplitude of the boundary surface roughness is required to be less than 4 micrometer. (Kato, T.)

  18. The effect of anterior proton beams in the setting of a prostate-rectum spacer

    Energy Technology Data Exchange (ETDEWEB)

    Christodouleas, John P., E-mail: christojo@uphs.upenn.edu [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA (United States); Tang, Shikui [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA (United States); Susil, Robert C.; McNutt, Todd R.; Song, Danny Y. [Department of Radiation Oncology and Radiation Molecular Sciences, Johns Hopkins Hospital, Baltimore, MD (United States); Bekelman, Justin; Deville, Curtiland; Vapiwala, Neha [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA (United States); DeWeese, Theodore L. [Department of Radiation Oncology and Radiation Molecular Sciences, Johns Hopkins Hospital, Baltimore, MD (United States); Lu, Hsiao-Ming [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Both, Stefan [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA (United States)

    2013-10-01

    Studies suggest that anterior beams with in vivo range verification would improve rectal dosimetry in proton therapy for prostate cancer. We investigated whether prostate-rectum spacers would enhance or diminish the benefits of anterior proton beams in these treatments. Twenty milliliters of hydrogel was injected between the prostate and rectum of a cadaver using a transperineal approach. Computed tomography (CT) and magnetic resonance (MR) images were used to generate 7 uniform scanning (US) and 7 single-field uniform dose pencil-beam scanning (PBS) plans with different beam arrangements. Pearson correlations were calculated between rectal, bladder, and femoral head dosimetric outcomes and beam arrangement anterior scores, which characterize the degree to which dose is delivered anteriorly. The overall quality of each plan was compared using a virtual dose-escalation study. For US plans, rectal mean dose was inversely correlated with anterior score, but for PBS plans there was no association between rectal mean dose and anterior score. For both US and PBS plans, full bladder and empty bladder mean doses were correlated with anterior scores. For both US and PBS plans, femoral head mean doses were inversely correlated with anterior score. For US plans and a full bladder, 4 beam arrangements that included an anterior beam tied for the highest maximum prescription dose (MPD). For US plans and an empty bladder, the arrangement with 1 anterior and 2 anterior oblique beams achieved the highest MPD in the virtual dose-escalation study. The dose-escalation study did not differentiate beam arrangements for PBS. All arrangements in the dose-escalation study were limited by bladder constraints except for the arrangement with 2 posterior oblique beams. The benefits of anterior proton beams in the setting of prostate-rectum spacers appear to be proton modality dependent and may not extend to PBS.

  19. The effect of anterior proton beams in the setting of a prostate-rectum spacer

    Science.gov (United States)

    Christodouleas, John P.; Tang, Shikui; Susil, Robert C.; McNutt, Todd R.; Song, Danny Y.; Bekelman, Justin; Deville, Curtiland; Vapiwala, Neha; DeWeese, Theodore L.; Lu, Hsiao-Ming; Both, Stefan

    2014-01-01

    Studies suggest that anterior beams with in vivo range verification would improve rectal dosimetry in proton therapy for prostate cancer. We investigated whether prostate-rectum spacers would enhance or diminish the benefits of anterior proton beams in these treatments. Twenty milliliters of hydrogel was injected between the prostate and rectum of a cadaver using a transperineal approach. Computed tomography (CT) and magnetic resonance (MR) images were used to generate 7 uniform scanning (US) and 7 single-field uniform dose pencil-beam scanning (PBS) plans with different beam arrangements. Pearson correlations were calculated between rectal, bladder, and femoral head dosimetric outcomes and beam arrangement anterior scores, which characterize the degree to which dose is delivered anteriorly. The overall quality of each plan was compared using a virtual dose-escalation study. For US plans, rectal mean dose was inversely correlated with anterior score, but for PBS plans there was no association between rectal mean dose and anterior score. For both US and PBS plans, full bladder and empty bladder mean doses were correlated with anterior scores. For both US and PBS plans, femoral head mean doses were inversely correlated with anterior score. For US plans and a full bladder, 4 beam arrangements that included an anterior beam tied for the highest maximum prescription dose (MPD). For US plans and an empty bladder, the arrangement with 1 anterior and 2 anterior oblique beams achieved the highest MPD in the virtual dose-escalation study. The dose-escalation study did not differentiate beam arrangements for PBS. All arrangements in the dose-escalation study were limited by bladder constraints except for the arrangement with 2 posterior oblique beams. The benefits of anterior proton beams in the setting of prostate-rectum spacers appear to be proton modality dependent and may not extend to PBS. PMID:23578497

  20. Efficient production and diagnostics of MeV proton beams from a cryogenic hydrogen ribbon

    International Nuclear Information System (INIS)

    Velyhan, A.; Giuffrida, L.; Scuderi, V.; Lastovicka, T.; Margarone, D.; Perin, J.P.; Chatain, D.; Garcia, S.; Bonnay, P.; Dostal, J.; Ullschmied, J.; Dudzak, R.; Krousky, E.; Cykhardt, J.; Prokupek, J.; Pfeifer, M.; Rosinski, M.; Krasa, J.; Brabcova, K.; Napoli, M. De

    2017-01-01

    A solid hydrogen thin ribbon, produced by the cryogenic system ELISE (Experiments on Laser Interaction with Solid hydrogEn) target delivery system, was experimentally used at the PALS kJ-laser facility to generate intense proton beams with energies in the MeV range. This sophisticated target system operating at cryogenic temperature (∼ 10 K) continuously producing a 62 μm thick target was combined with a 600 J sub-nanosecond laser pulse to generate a collimated proton stream. The accelerated proton beams were fully characterized by a number of diagnostics. High conversion efficiency of laser to energetic protons is of great interest for future potential applications in non-conventional proton therapy and fast ignition for inertial confinement fusion.

  1. Benchmark measurements and simulations of dose perturbations due to metallic spheres in proton beams

    International Nuclear Information System (INIS)

    Newhauser, Wayne D.; Rechner, Laura; Mirkovic, Dragan; Yepes, Pablo; Koch, Nicholas C.; Titt, Uwe; Fontenot, Jonas D.; Zhang, Rui

    2013-01-01

    Monte Carlo simulations are increasingly used for dose calculations in proton therapy due to its inherent accuracy. However, dosimetric deviations have been found using Monte Carlo code when high density materials are present in the proton beamline. The purpose of this work was to quantify the magnitude of dose perturbation caused by metal objects. We did this by comparing measurements and Monte Carlo predictions of dose perturbations caused by the presence of small metal spheres in several clinical proton therapy beams as functions of proton beam range and drift space. Monte Carlo codes MCNPX, GEANT4 and Fast Dose Calculator (FDC) were used. Generally good agreement was found between measurements and Monte Carlo predictions, with the average difference within 5% and maximum difference within 17%. The modification of multiple Coulomb scattering model in MCNPX code yielded improvement in accuracy and provided the best overall agreement with measurements. Our results confirmed that Monte Carlo codes are well suited for predicting multiple Coulomb scattering in proton therapy beams when short drift spaces are involved. - Highlights: • We compared measurements and Monte Carlo predictions of dose perturbations caused by the metal objects in proton beams. • Different Monte Carlo codes were used, including MCNPX, GEANT4 and Fast Dose Calculator. • Good agreement was found between measurements and Monte Carlo simulations. • The modification of multiple Coulomb scattering model in MCNPX code yielded improved accuracy. • Our results confirmed that Monte Carlo codes are well suited for predicting multiple Coulomb scattering in proton therapy

  2. Polarized proton and deuteron targets for the usage in intensive proton beams

    International Nuclear Information System (INIS)

    Get'man, V.A.; Derkach, A.Ya.; Karnaukhov, I.M.; Lukhanin, A.A.; Razumnyj, A.A.; Sorokin, P.V.; Sporo, E.A.; Telegin, Yu.N.

    1982-01-01

    Polarized proton and deuteron targets are developed and tested for conducting investigations in intense photon beams. A flowsheet of polarization targets which includes: working agent of the target, superconducting magnet, cryostat of 3 He evaporation with 3 He pumping and recirculation systems, SHF system of 4 mm range for polarization pumping, measuring system of target polarization protons is presented. Working agent of the targets includes frozen balls with 1.5 mm diameter. Ethylene-glucol and 1.2-propylene-glycol were used as a working substance for proton targets. Completely deuterated ethylene-glycol was used for the deuteron target. Vertical magnetic field with 2.7 T intensity is produced by a superconducting magnetic system. Polarization pumping is exercised at 75 GHz frequency. Q-meter of direct current is used for determination of polarization. Working temperature of the cryostat is approximately 0.5 K. The lock device permits to exercise replacement of the target working agent during 30 minutes

  3. Numerical Studies of Electron Acceleration Behind Self-Modulating Proton Beam in Plasma with a Density Gradient

    CERN Document Server

    Petrenko, A.; Sosedkin, A.

    2016-01-01

    Presently available high-energy proton beams in circular accelerators carry enough momentum to accelerate high-intensity electron and positron beams to the TeV energy scale over several hundred meters of the plasma with a density of about 1e15 1/cm^3. However, the plasma wavelength at this density is 100-1000 times shorter than the typical longitudinal size of the high-energy proton beam. Therefore the self-modulation instability (SMI) of a long (~10 cm) proton beam in the plasma should be used to create the train of micro-bunches which would then drive the plasma wake resonantly. Changing the plasma density profile offers a simple way to control the development of the SMI and the acceleration of particles during this process. We present simulations of the possible use of a plasma density gradient as a way to control the acceleration of the electron beam during the development of the SMI of a 400 GeV proton beam in a 10 m long plasma. This work is done in the context of the AWAKE project --- the proof-of-prin...

  4. Technical Note: Using experimentally determined proton spot scanning timing parameters to accurately model beam delivery time.

    Science.gov (United States)

    Shen, Jiajian; Tryggestad, Erik; Younkin, James E; Keole, Sameer R; Furutani, Keith M; Kang, Yixiu; Herman, Michael G; Bues, Martin

    2017-10-01

    To accurately model the beam delivery time (BDT) for a synchrotron-based proton spot scanning system using experimentally determined beam parameters. A model to simulate the proton spot delivery sequences was constructed, and BDT was calculated by summing times for layer switch, spot switch, and spot delivery. Test plans were designed to isolate and quantify the relevant beam parameters in the operation cycle of the proton beam therapy delivery system. These parameters included the layer switch time, magnet preparation and verification time, average beam scanning speeds in x- and y-directions, proton spill rate, and maximum charge and maximum extraction time for each spill. The experimentally determined parameters, as well as the nominal values initially provided by the vendor, served as inputs to the model to predict BDTs for 602 clinical proton beam deliveries. The calculated BDTs (T BDT ) were compared with the BDTs recorded in the treatment delivery log files (T Log ): ∆t = T Log -T BDT . The experimentally determined average layer switch time for all 97 energies was 1.91 s (ranging from 1.9 to 2.0 s for beam energies from 71.3 to 228.8 MeV), average magnet preparation and verification time was 1.93 ms, the average scanning speeds were 5.9 m/s in x-direction and 19.3 m/s in y-direction, the proton spill rate was 8.7 MU/s, and the maximum proton charge available for one acceleration is 2.0 ± 0.4 nC. Some of the measured parameters differed from the nominal values provided by the vendor. The calculated BDTs using experimentally determined parameters matched the recorded BDTs of 602 beam deliveries (∆t = -0.49 ± 1.44 s), which were significantly more accurate than BDTs calculated using nominal timing parameters (∆t = -7.48 ± 6.97 s). An accurate model for BDT prediction was achieved by using the experimentally determined proton beam therapy delivery parameters, which may be useful in modeling the interplay effect and patient throughput. The model may

  5. SU-E-T-665: Radiochromic Film Quenching Effect Reduction for Proton Beam Dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Aldelaijan, S; Alzorkany, F; Moftah, B; Alrumayan, F [King Faisal Specialist Hospital & Research Centre, Riyadh (Saudi Arabia); Seuntjens, J [McGill University, Montreal, QC (Canada); Lewis, D [RCF Consulting, LLC, Monroe, CT (United States); Devic, S [McGill University, Montreal, QC (Canada); Jewish General Hospital, Montreal, QC (Canada)

    2015-06-15

    Purpose: Depending on the useful dose range in which radiochromic films operate, number of different radiochromic film models have been designed. The impact of different film models on quenching effect for percent depth dose (PDD) measurements in proton beams has been investigated. Methods: Calibrated PTW Markus ionization chamber was used to measure PDD and beam output for 26.5 MeV protons produced by CS30 cyclotron. An aluminum cylinder was added in front of the beam exit serving as a radiation shutter. The measured signal was normalized to a monitor chamber reading and subsequently scaled by ratio of water-to-air stopping powers at given depth, while the effective depth of measurements was scaled by ratios of material-to-water physical densities and CSDA ranges. Output was measured in water at 2.1 mm reference-depth in the plateau upstream from the Bragg peak. Following the TRS-398 reference dosimetry protocol for proton beams, the output was calibrated in water. Three radiochromic film models (EBT, EBT3 and HD-V2) were calibrated within Lexan phantom positioned at the same water-equivalent depth. Thicknesses of films sensitive layers were 34 µm, 30 µm and 8 µm, respectively. Small film pieces (1 x 2 cm{sup 2}) were positioned within polyethylene phantom along the beam central axis with an angulation of 5° for PDD measurements. Results: While the output of the proton beam was found to be around 7 Gy/sec, the actual value of the output per monitor chamber reading (2.32 Gy/nC) was used for reference-dose irradiations during film calibration. Dose ratios at the Bragg peak relative to the reference-depth were 3.88, 2.52, 2.19, and 2.02 for the Markus chamber, HD-V2, EBT3, and EBT film models, respectively. Conclusion: Results at hand suggest that quenching effect is reduced when a radiochromic film model with smaller sensitive layer thickness is used for PDD measurements in proton beams. David Lewis is the owner of RCF Consulting, LLC.

  6. SU-E-J-49: Distal Edge Activity Fall Off Of Proton Therapy Beams

    Energy Technology Data Exchange (ETDEWEB)

    Elmekawy, A; Ewell, L [Hampton University, Hampton, VA (United States); Butuceanu, C; Zhu, L [HUPTI, Hampton, VA (United States)

    2014-06-01

    Purpose: To characterize and quantify the distal edge activity fall off, created in a phantom by a proton therapy beam Method and Materials: A 30x30x10cm polymethylmethacrylate phantom was irradiated with a proton therapy beam using different ranges and beams. The irradiation volume is approximated by a right circular cylinder of diameter 7.6cm and varying lengths. After irradiation, the phantom was scanned via a Philips Gemini Big Bore™ PET-CT for isotope activation. Varian Eclipse™ treatment planning system as well as ImageJ™ were used to analyze the resulting PET and CT scans. The region of activity within the phantom was longitudinally measured as a function of PET slice number. Dose estimations were made via Monte Carlo (GATE) simulation. Results: For both the spread out Bragg peak (SOBP) and the mono-energetic pristine Bragg peak proton beams, the proximal activation rise was steep: average slope −0.735 (average intensity/slice number) ± 0.091 (standard deviation) for the pristine beams and −1.149 ± 0.117 for the SOBP beams. In contrast, the distal fall offs were dissimilar. The distal fall off in activity for the pristine beams was fit well by a linear curve: R{sup 2} (Pierson Product) was 0.9968, 0.9955 and 0.9909 for the 13.5, 17.0 and 21.0cm range beams respectively. The good fit allows for a slope comparison between the different ranges. The slope varied as a function of range from 1.021 for the 13.5cm beam to 0.8407 (average intensity/slice number) for the 21.0cm beam. This dependence can be characterized: −0.0234(average intensity/slice number/cm range). For the SOBP beams, the slopes were significantly less and were also less linear: average slope 0.2628 ± 0.0474, average R{sup 2}=0.9236. Conclusion: The distal activation fall off edge for pristine proton beams was linear and steep. The corresponding quantities for SOBP beams were shallower and less linear. Philips has provided support for this work.

  7. Beam optics on the Melbourne proton microprobe

    International Nuclear Information System (INIS)

    Jamieson, D.N.; Colman, R.A.; Allan, G.L.; Legge, G.J.F.

    1985-01-01

    This review paper summarises results of ion optics development work conducted on the Melbourne Proton Microprobe and the associated Pelletron accelerator. The properties of a field ionization ion source have been investigated with the aim of replacing the existing R.F. ion source in the accelerator in order to obtain a brighter beam for the microprobe. The electrostatic emitter lens in the terminal of the accelerator has also been investigated with the aim of improving the focus of the accelerated beam. Finally, the aberrations of the probe forming lens system have been studied and it is shown how some of these may be corrected with an octupole lens

  8. Dark Matter Search in a Proton Beam Dump with MiniBooNE.

    Science.gov (United States)

    Aguilar-Arevalo, A A; Backfish, M; Bashyal, A; Batell, B; Brown, B C; Carr, R; Chatterjee, A; Cooper, R L; deNiverville, P; Dharmapalan, R; Djurcic, Z; Ford, R; Garcia, F G; Garvey, G T; Grange, J; Green, J A; Huelsnitz, W; de Icaza Astiz, I L; Karagiorgi, G; Katori, T; Ketchum, W; Kobilarcik, T; Liu, Q; Louis, W C; Marsh, W; Moore, C D; Mills, G B; Mirabal, J; Nienaber, P; Pavlovic, Z; Perevalov, D; Ray, H; Roe, B P; Shaevitz, M H; Shahsavarani, S; Stancu, I; Tayloe, R; Taylor, C; Thornton, R T; Van de Water, R; Wester, W; White, D H; Yu, J

    2017-06-02

    The MiniBooNE-DM Collaboration searched for vector-boson mediated production of dark matter using the Fermilab 8-GeV Booster proton beam in a dedicated run with 1.86×10^{20} protons delivered to a steel beam dump. The MiniBooNE detector, 490 m downstream, is sensitive to dark matter via elastic scattering with nucleons in the detector mineral oil. Analysis methods developed for previous MiniBooNE scattering results were employed, and several constraining data sets were simultaneously analyzed to minimize systematic errors from neutrino flux and interaction rates. No excess of events over background was observed, leading to a 90% confidence limit on the dark matter cross section parameter, Y=ε^{2}α_{D}(m_{χ}/m_{V})^{4}≲10^{-8}, for α_{D}=0.5 and for dark matter masses of 0.01dark matter. This is the best limit from a dedicated proton beam dump search in this mass and coupling range and extends below the mass range of direct dark matter searches. These results demonstrate a novel and powerful approach to dark matter searches with beam dump experiments.

  9. Development of linear proton accelerators with the high average beam power

    CERN Document Server

    Bomko, V A; Egorov, A M

    2001-01-01

    Review of the current situation in the development of powerful linear proton accelerators carried out in many countries is given. The purpose of their creation is solving problems of safe and efficient nuclear energetics on a basis of the accelerator-reactor complex. In this case a proton beam with the energy up to 1 GeV, the average current of 30 mA is required. At the same time there is a needed in more powerful beams,for example, for production of tritium and transmutation of nuclear waste products. The creation of accelerators of such a power will be followed by the construction of linear accelerators of 1 GeV but with a more moderate beam current. They are intended for investigation of many aspects of neutron physics and neutron engineering. Problems in the creation of efficient constructions for the basic and auxiliary equipment, the reliability of the systems, and minimization of the beam losses in the process of acceleration will be solved.

  10. On Start to End Simulation and Modeling Issues of the Megawatt Proton Beam Facility at PSI

    CERN Document Server

    Adelmann, Andreas; Fitze, Hansruedi; Geus, Roman; Humbel, Martin; Stingelin, Lukas

    2005-01-01

    At the Paul Scherrer Institut (PSI) we routinely extract a one megawatt (CW) proton beam out of our 590 MeV Ring Cyclotron. In the frame of the ongoing upgrade program, large scale simulations have been undertaken in order to provide a sound basis to assess the behaviour of very intense beams in cyclotrons. The challenges and attempts towards massive parallel three dimensional start-to- end simulations will be discussed. The used state of the art numerical tools (mapping techniques, time integration, parallel FFT and finite element based multigrid Poisson solver) and their parallel implementation will be discussed. Results will be presented in the area of: space charge dominated beam transport including neighbouring turns, eigenmode analysis to obtain accurate electromagnetic fields in large the rf cavities and higher order mode interaction between the electromagnetic fields and the particle beam. For the problems investigated so far a good agreement between theory i.e. calculations and measurements is obtain...

  11. Structure modification and medical application of the natural products by proton beam irradiation

    International Nuclear Information System (INIS)

    Lee, D. W.; Park, J. K.; Kang, J. E.; Shin, S. C.; Ahn, J. H.; Lee, E. S.

    2008-04-01

    This study was performed for the investigation of changes of constituent contents of Korean ginseng (Panax genseng C.A. Meyer) after proton beam irradiation (Beam energy from MC-50 cyclotron : 36.5MeV) with beam range of 500 - 10000Gy

  12. Structure modification and medical application of the natural products by proton beam irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, D. W.; Park, J. K.; Kang, J. E.; Shin, S. C.; Ahn, J. H.; Lee, E. S. [Dongguk University, Gyeongju (Korea, Republic of)

    2008-04-15

    This study was performed for the investigation of changes of constituent contents of Korean ginseng (Panax genseng C.A. Meyer) after proton beam irradiation (Beam energy from MC-50 cyclotron : 36.5MeV) with beam range of 500 - 10000Gy

  13. The potential of proton beam radiation therapy in lung cancer (including mesothelioma)

    Energy Technology Data Exchange (ETDEWEB)

    Bjelkengren, Goeran [Univ. Hospital, Malmoe (Sweden). Dept. of Oncology; Glimelius, Bengt [Karolinska Inst., Stockholm (Sweden). Dept. of Oncology and Pathology; Akademiska sjukhuset, Uppsala (Sweden). Dept. of Oncology, Radiology and Clinical Immunology

    2005-12-01

    A Swedish group of oncologists and hospital physicists have estimated the number of patients in Sweden suitable for proton beam therapy. The estimations have been based on current statistics of tumour incidence, number of patients potentially eligible for radiation treatment, scientific support from clinical trials and model dose planning studies and knowledge of the dose-response relations of different tumours and normal tissues. It is estimated that about 350 patients with lung cancer and about 20 patients with mesothelioma annually may benefit from proton beam therapy.

  14. Development of over-production strain of saccharification enzyme and biomass pretreatment by proton beam irradiation

    International Nuclear Information System (INIS)

    Kim, S. O.; Lee, J. Y.; Song, Y. S.; Shin, H. S.

    2009-04-01

    - The first year : Pre-treatment of biomass by proton beam irradiation and characterization of the pretreated biomass by IR and SEM - The second year : Strain development by proton beam irradiation for the production of cellulase and hemicellulase - The third year : Optimization of Saccharification process by cellulase and hemicellulase

  15. Beam tube vacuum in future superconducting proton colliders

    International Nuclear Information System (INIS)

    Turner, W.

    1994-10-01

    The beam tube vacuum requirements in future superconducting proton colliders that have been proposed or discussed in the literature -- SSC, LHC, and ELN -- are reviewed. The main beam tube vacuum problem encountered in these machines is how to deal with the magnitude of gas desorption and power deposition by synchrotron radiation while satisfying resistivity, impedance, and space constraints in the cryogenic environment of superconducting magnets. A beam tube vacuum model is developed that treats photodesorption of tightly bound H, C, and 0, photodesorption of physisorbed molecules, and the isotherm vapor pressure of H 2 . Experimental data on cold tube photodesorption experiments are reviewed and applied to model calculations of beam tube vacuum performance for simple cold beam tube and liner configurations. Particular emphasis is placed on the modeling and interpretation of beam tube photodesorpiion experiments at electron synchrotron light sources. The paper also includes discussion of the constraints imposed by beam image current heating, the growth rate of the resistive wall instability, and single-bunch instability impedance limits

  16. An integral test of FLUKA nuclear models with 160 MeV proton beams in multi-layer Faraday cups

    CERN Document Server

    Rinaldi, I; Parodi, K; Ferrari, A; Sala, P; Mairani, A

    2011-01-01

    Monte Carlo (MC) codes are useful tools to simulate the complex processes of proton beam interactions with matter. In proton therapy, nuclear reactions influence the dose distribution. Therefore, the validation of nuclear models adopted in MC codes is a critical requisite for their use in this field. A simple integral test can be performed using a multi-layer Faraday cup (MLFC). This method allows separation of the nuclear and atomic interaction processes, which are responsible for secondary particle emission and the finite primary proton range, respectively. In this work, the propagation of 160 MeV protons stopping in two MLFCs made of polyethylene and copper has been simulated by the FLUKA MC code. The calculations have been performed with and without secondary electron emission and transport, as well as charge sharing in the dielectric layers. Previous results with other codes neglected those two effects. The impact of this approximation has been investigated and found to be relevant only in the proximity ...

  17. Transport of protons and lactate in cultured human fetal retinal pigment epithelial cells

    DEFF Research Database (Denmark)

    Hamann, Steffen; Cour, Morten la; Ming Lui, Ge

    2000-01-01

    Electron microscopy, intracellular pH, monocarboxylate transport, pigment epithelium of eye, proton-lactate cotransport, retinal metabolism, sodium/proton exchange......Electron microscopy, intracellular pH, monocarboxylate transport, pigment epithelium of eye, proton-lactate cotransport, retinal metabolism, sodium/proton exchange...

  18. Impact of high energy high intensity proton beams on targets: Case studies for Super Proton Synchrotron and Large Hadron Collider

    CERN Document Server

    Tahir, N A; Shutov, A; Schmidt, R; Piriz, A R

    2012-01-01

    The Large Hadron Collider (LHC) is designed to collide two proton beams with unprecedented particle energy of 7 TeV. Each beam comprises 2808 bunches and the separation between two neighboring bunches is 25 ns. The energy stored in each beam is 362 MJ, sufficient to melt 500 kg copper. Safety of operation is very important when working with such powerful beams. An accidental release of even a very small fraction of the beam energy can result in severe damage to the equipment. The machine protection system is essential to handle all types of possible accidental hazards; however, it is important to know about possible consequences of failures. One of the critical failure scenarios is when the entire beam is lost at a single point. In this paper we present detailed numerical simulations of the full impact of one LHC beam on a cylindrical solid carbon target. First, the energy deposition by the protons is calculated with the FLUKA code and this energy deposition is used in the BIG2 code to study the corresponding...

  19. High-Efficiency Volume Reflection of an Ultrarelativistic Proton Beam with a Bent Silicon Crystal

    CERN Document Server

    Scandale, Walter; Carnera, Alberto; Della Mea, Gianantonio; De Salvador, Davide; Milan, Riccardo; Vomiero, Alberto; Baricordi, Stefano; Dalpiaz, Pietro; Fiorini, Massimiliano; Guidi, Vincenzo; Martinelli,Giuliano; Mazzolari, Andrea; Milan, Emiliano; Ambrosi, Giovanni; Azzarello, Philipp; Battiston, Roberto; Bertucci, Bruna; Burger, William J; Ionica, Maria; Zuccon, Paolo; Cavoto, Gianluca; Santacesaria, Roberta; Valente, Paolo; Vallazza, Erik; Afonin, Alexander G; Baranov, Vladimir T; Chesnokov, Yury A; Kotov, Vladilen I; Maisheev, Vladimir A; Yaznin, Igor A; Afansiev, Sergey V; Kovalenko, Alexander D; Taratin, Alexander M; Denisov, Alexander S; Gavrikov, Yury A; Ivanov, Yuri M; Ivochkin, Vladimir G; Kosyanenko, Sergey V; Petrunin, Anatoli A; Skorobogatov, Vyacheslav V; Suvorov, Vsevolod M; Bolognini, Davide; Foggetta,Luca; Hasan, Said; Prest, Michela

    2007-01-01

    The volume reflection phenomenon was detected while investigating 400 GeV proton interactions with bent silicon crystals in the external beam H8 of the CERN Super Proton Synchrotron. Such a process was observed for a wide interval of crystal orientations relative to the beam axis, and its efficiency exceeds 95%, thereby surpassing any previously observed value. These observations suggest new perspectives for the manipulation of high-energy beams, e.g., for collimation and extraction in new-generation hadron colliders, such as the CERN Large Hadron Collider.

  20. Extraction design and low energy beam transport optimization of space charge dominated multispecies ion beam sources

    International Nuclear Information System (INIS)

    Delferriere, O.; De Menezes, D.

    2004-01-01

    In all accelerator projects, the low energy part of the accelerator has to be carefully optimized to match the beam characteristic requirements of the higher energy parts. Since 1994 with the beginning of the Injector of Protons for High Intensity (IPHI) project and Source of Light Ions with High Intensities (SILHI) electron cyclotron resonance (ECR) ion source development at CEA/Saclay, we are using a set of two-dimensional (2D) codes for extraction system optimization (AXCEL, OPERA-2D) and beam transport (MULTIPART). The 95 keV SILHI extraction system optimization has largely increased the extracted current, and improved the beam line transmission. From these good results, a 130 mA D + extraction system for the International Fusion Material Irradiation Facility project has been designed in the same way as SILHI one. We are also now involved in the SPIRAL 2 project for the building of a 40 keV D + ECR ion source, continuously tunable from 0.1 to 5 mA, for which a special four-electrode extraction system has been studied. In this article we will describe the 2D design process and present the different extraction geometries and beam characteristics. Simulation results of SILHI H + beam emittance will be compared with experimental measurements

  1. Proton beam stereotactic radiosurgery of vestibular schwannomas

    International Nuclear Information System (INIS)

    Harsh, Griffith R.; Thornton, Allan F.; Chapman, Paul H.; Bussiere, Marc R.; Rabinov, James D.; Loeffler, Jay S.

    2002-01-01

    Purpose: The proton beam's Bragg peak permits highly conformal radiation of skull base tumors. This study, prompted by reports of transient (30% each) and permanent (10% each) facial and trigeminal neuropathy after stereotactic radiosurgery of vestibular schwannomas with marginal doses of 16-20 Gy, assessed whether proton beam radiosurgery using a marginal dose of only 12 Gy could control vestibular schwannomas while causing less neuropathy. Methods and Materials: Sixty-eight patients (mean age 67 years) were treated between 1992 and 1998. The mean tumor volume was 2.49 cm 3 . The dose to the tumor margin (70% isodose line) was 12 Gy. The prospectively specified follow-up consisted of neurologic evaluation and MRI at 6, 12, 24, and 36 months. Results: After a mean clinical follow-up of 44 months and imaging follow-up of 34 months in 64 patients, 35 tumors (54.7%) were smaller and 25 (39.1%) were unchanged (tumor control rate 94%; actuarial control rate 94% at 2 years and 84% at 5 years). Three tumors enlarged: one shrank after repeated radiosurgery, one remained enlarged at the time of unrelated death, and one had not been imaged for 4 years in a patient who remained asymptomatic at last follow-up. Intratumoral hemorrhage into one stable tumor required craniotomy that proved successful. Thus, 97% of tumors required no additional treatment. Three patients (4.7%) underwent shunting for hydrocephalus evident as increased ataxia. Of 6 patients with functional hearing ipsilaterally, 1 improved, 1 was unchanged, and 4 progressively lost hearing. Cranial neuropathies were infrequent: persistent facial hypesthesia (2 new, 1 exacerbated; 4.7%); intermittent facial paresthesias (5 new, 1 exacerbated; 9.4%); persistent facial weakness (2 new, 1 exacerbated; 4.7%) requiring oculoplasty; transient partial facial weakness (5 new, 1 exacerbated; 9.4%), and synkinesis (5 new, 1 exacerbated; 9.4%). Conclusion: Proton beam stereotactic radiosurgery of vestibular schwannomas at the

  2. Improved spectral data unfolding for radiochromic film imaging spectroscopy of laser-accelerated proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Schollmeier, M.; Geissel, M.; Sefkow, A. B. [Sandia National Laboratories, Albuquerque, New Mexico 87185 (United States); Flippo, K. A. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)

    2014-04-15

    An improved method to unfold the space-resolved proton energy distribution function of laser-accelerated proton beams using a layered, radiochromic film (RCF) detector stack has been developed. The method takes into account the reduced RCF response near the Bragg peak due to a high linear energy transfer (LET). This LET dependence of the active RCF layer has been measured, and published data have been re-interpreted to find a nonlinear saturation scaling of the RCF response with stopping power. Accounting for the LET effect increased the integrated particle yield by 25% after data unfolding. An iterative, analytical, space-resolved deconvolution of the RCF response functions from the measured dose was developed that does not rely on fitting. After the particle number unfold, three-dimensional interpolation is performed to determine the spatial proton beam distribution for proton energies in-between the RCF data points. Here, image morphing has been implemented as a novel interpolation method that takes into account the energy-dependent, changing beam topology.

  3. A Fourier analysis on the maximum acceptable grid size for discrete proton beam dose calculation

    International Nuclear Information System (INIS)

    Li, Haisen S.; Romeijn, H. Edwin; Dempsey, James F.

    2006-01-01

    We developed an analytical method for determining the maximum acceptable grid size for discrete dose calculation in proton therapy treatment plan optimization, so that the accuracy of the optimized dose distribution is guaranteed in the phase of dose sampling and the superfluous computational work is avoided. The accuracy of dose sampling was judged by the criterion that the continuous dose distribution could be reconstructed from the discrete dose within a 2% error limit. To keep the error caused by the discrete dose sampling under a 2% limit, the dose grid size cannot exceed a maximum acceptable value. The method was based on Fourier analysis and the Shannon-Nyquist sampling theorem as an extension of our previous analysis for photon beam intensity modulated radiation therapy [J. F. Dempsey, H. E. Romeijn, J. G. Li, D. A. Low, and J. R. Palta, Med. Phys. 32, 380-388 (2005)]. The proton beam model used for the analysis was a near mono-energetic (of width about 1% the incident energy) and monodirectional infinitesimal (nonintegrated) pencil beam in water medium. By monodirection, we mean that the proton particles are in the same direction before entering the water medium and the various scattering prior to entrance to water is not taken into account. In intensity modulated proton therapy, the elementary intensity modulation entity for proton therapy is either an infinitesimal or finite sized beamlet. Since a finite sized beamlet is the superposition of infinitesimal pencil beams, the result of the maximum acceptable grid size obtained with infinitesimal pencil beam also applies to finite sized beamlet. The analytic Bragg curve function proposed by Bortfeld [T. Bortfeld, Med. Phys. 24, 2024-2033 (1997)] was employed. The lateral profile was approximated by a depth dependent Gaussian distribution. The model included the spreads of the Bragg peak and the lateral profiles due to multiple Coulomb scattering. The dependence of the maximum acceptable dose grid size on the

  4. Water equivalent thickness values of materials used in beams of protons, helium, carbon and iron ions.

    Science.gov (United States)

    Zhang, Rui; Taddei, Phillip J; Fitzek, Markus M; Newhauser, Wayne D

    2010-05-07

    Heavy charged particle beam radiotherapy for cancer is of increasing interest because it delivers a highly conformal radiation dose to the target volume. Accurate knowledge of the range of a heavy charged particle beam after it penetrates a patient's body or other materials in the beam line is very important and is usually stated in terms of the water equivalent thickness (WET). However, methods of calculating WET for heavy charged particle beams are lacking. Our objective was to test several simple analytical formulas previously developed for proton beams for their ability to calculate WET values for materials exposed to beams of protons, helium, carbon and iron ions. Experimentally measured heavy charged particle beam ranges and WET values from an iterative numerical method were compared with the WET values calculated by the analytical formulas. In most cases, the deviations were within 1 mm. We conclude that the analytical formulas originally developed for proton beams can also be used to calculate WET values for helium, carbon and iron ion beams with good accuracy.

  5. Focused proton beams propagating in reactor of fusion power plant

    Energy Technology Data Exchange (ETDEWEB)

    Niu, K [Teikyo Heisei Univ., Uruido, Ichihara, Chiba (Japan)

    1997-12-31

    One of the difficult tasks of light ion beam fusion is to propagate the beam in the reactor cavity and to focus the beam on the target. The light ion beam has a certain local divergence angle because there are several causes for divergence at the diode. The electrostatic force induced at the leading edge causes beam divergence during propagation. To confine the beam within a small radius during propagation, the magnetic field must be employed. Here the electron beam is proposed to be launched simultaneously with the launching of the proton beam. If the electron beam has the excess current, the beam induces a magnetic field in the negative azimuthal direction, which confines the ion beam within a small radius by the electrostatic field as well as the electron beam by the Lorentz force. The metal guide around the beam path helps the beam confinement and reduces the total amount of magnetic field energy induced by the electron current. (author). 2 figs., 15 refs.

  6. Proton and hydrogen transport through two-dimensional monolayers

    International Nuclear Information System (INIS)

    Seel, Max; Pandey, Ravindra

    2016-01-01

    Diffusion of protons and hydrogen atoms in representative two-dimensional materials is investigated. Specifically, density functional calculations were performed on graphene, hexagonal boron nitride (h-BN), phosphorene, silicene, and molybdenum disulfide (MoS 2 ) monolayers to study the surface interaction and penetration barriers for protons and hydrogen atoms employing finite cluster models. The calculated barrier heights correlate approximately with the size of the opening formed by the three-fold open sites in the monolayers considered. They range from 1.56 eV (proton) and 4.61 eV (H) for graphene to 0.12 eV (proton) and 0.20 eV (H) for silicene. The results indicate that only graphene and h-BN monolayers have the potential for membranes with high selective permeability. The MoS 2 monolayer behaves differently: protons and H atoms become trapped between the outer S layers in the Mo plane in a well with a depth of 1.56 eV (proton) and 1.5 eV (H atom), possibly explaining why no proton transport was detected, suggesting MoS 2 as a hydrogen storage material instead. For graphene and h-BN, off-center proton penetration reduces the barrier to 1.38 eV for graphene and 0.11 eV for h-BN. Furthermore, Pt acting as a substrate was found to have a negligible effect on the barrier height. In defective graphene, the smallest barrier for proton diffusion (1.05 eV) is found for an oxygen-terminated defect. Therefore, it seems more likely that thermal protons can penetrate a monolayer of h-BN but not graphene and defects are necessary to facilitate the proton transport in graphene. (paper)

  7. Proton and hydrogen transport through two-dimensional monolayers

    Science.gov (United States)

    Seel, Max; Pandey, Ravindra

    2016-06-01

    Diffusion of protons and hydrogen atoms in representative two-dimensional materials is investigated. Specifically, density functional calculations were performed on graphene, hexagonal boron nitride (h-BN), phosphorene, silicene, and molybdenum disulfide (MoS2) monolayers to study the surface interaction and penetration barriers for protons and hydrogen atoms employing finite cluster models. The calculated barrier heights correlate approximately with the size of the opening formed by the three-fold open sites in the monolayers considered. They range from 1.56 eV (proton) and 4.61 eV (H) for graphene to 0.12 eV (proton) and 0.20 eV (H) for silicene. The results indicate that only graphene and h-BN monolayers have the potential for membranes with high selective permeability. The MoS2 monolayer behaves differently: protons and H atoms become trapped between the outer S layers in the Mo plane in a well with a depth of 1.56 eV (proton) and 1.5 eV (H atom), possibly explaining why no proton transport was detected, suggesting MoS2 as a hydrogen storage material instead. For graphene and h-BN, off-center proton penetration reduces the barrier to 1.38 eV for graphene and 0.11 eV for h-BN. Furthermore, Pt acting as a substrate was found to have a negligible effect on the barrier height. In defective graphene, the smallest barrier for proton diffusion (1.05 eV) is found for an oxygen-terminated defect. Therefore, it seems more likely that thermal protons can penetrate a monolayer of h-BN but not graphene and defects are necessary to facilitate the proton transport in graphene.

  8. Dosimetric comparison between proton and photon beams in the moving gap region in cranio-spinal irradiation (CSI)

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Chee-Wai; Das, Indra J.; Zhao, Li; Wolanski, Mark; Johnstone, Peter A.S.; Buchsbaum, Jeffrey C. [IU Health Proton Therapy Center, Bloomington (United States); Dept. of Radiation Oncology, Indiana Univ. School of Medicine, Indianapolis (United States)], e-mail: ccheng1@iuhealth.org; Srivastava, Shiv P. [Dept. of Radiation Oncology, Indiana Univ. School of Medicine, Indianapolis (United States); Dept. of Radiation Oncology, Reid Hospital, Richmond (United States); Simmons, Joseph [IU Health Proton Therapy Center, Bloomington (United States)

    2013-04-15

    Purpose: To investigate the moving gap region dosimetry in proton beam cranio-spinal irradiation (CSI) to provide optimal dose uniformity across the treatment volume. Material and methods: Proton beams of ranges 11.6 cm and 16 cm are used for the spine and the brain fields, respectively. Beam profiles for a 30 cm snout are first matched at the 50% level (hot match) on the computer. Feathering is simulated by shifting the dose profiles by a known distance two successive times to simulate a 2 x feathering scheme. The process is repeated for 2 mm and 4 mm gaps. Similar procedures are used to determine the dose profiles in the moving gap for a series of gap widths, 0-10 mm, and feathering step sizes, 4-10 mm, for a Varian iX 6MV beam. The proton and photon dose profiles in the moving gap region are compared. Results: The dose profiles in the moving gap exhibit valleys and peaks in both proton and photon beam CSI. The dose in the moving gap for protons is around 100% or higher for 0 mm gap, for both 5 and 10 mm feathering step sizes. When the field gap is comparable or larger than the penumbra, dose minima as low as 66% is obtained. The dosimetric characteristics for 6 MV photon beams can be made similar to those of the protons by appropriately combining gap width and feathering step size. Conclusion: The dose in the moving gap region is determined by the lateral penumbras, the width of the gap and the feathering step size. The dose decreases with increasing gap width or decreasing feathering step size. The dosimetric characteristics are similar for photon and proton beams. However, proton CSI has virtually no exit dose and is beneficial for pediatric patients, whereas with photon beams the whole lung and abdomen receive non-negligible exit dose.

  9. SU-E-T-542: Measurement of Internal Neutrons for Uniform Scanning Proton Beams

    Energy Technology Data Exchange (ETDEWEB)

    Islam, M; Ahmad, S [University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (United States); Zheng, Y; Rana, S [Procure Proton Therapy Center, Oklahoma City, OK (United States); Collums, T [University of Iowa Hospitals and Clinics, Iowa City, IA (United States); Monsoon, J; Benton, E [Oklahoma State University, Stillwater, OK (United States)

    2015-06-15

    Purpose: In proton radiotherapy, the production of neutrons is a wellknown problem since neutron exposure can lead to increased risk of secondary cancers later in the patient’s lifetime. The assessment of neutron exposure is, therefore, important for the overall quality of proton radiotherapy. This study investigates the secondary neutrons created inside the patient from uniform scanning proton beams. Methods: Dose equivalent due to secondary neutrons was measured outside the primary field as a function of distance from beam isocenter at three different angles, 45, 90 and 135 degree, relative to beam axis. Plastic track nuclear detector (CR-39 PNTD) was used for the measurement of neutron dose. Two experimental configurations, in-air and cylindrical-phantom, were designed. In a cylindrical-phantom configuration, a cylindrical phantom of 5.5 cm diameter and 35 cm long was placed along the beam direction and in an in-air configuration, no phantom was used. All the detectors were placed at nearly identical locations in both configurations. Three proton beams of range 5 cm, 18 cm, and 32 cm with 4 cm modulation width and a 5 cm diameter aperture were used. The contribution from internal neutrons was estimated from the differences in measured dose equivalent between in-air and cylindrical-phantom configurations at respective locations. Results: The measured ratio of neutron dose equivalent to the primary proton dose (H/D) dropped off with distance and ranged from 27 to 0.3 mSv/Gy. The contribution of internal neutrons near the treatment field edge was found to be up to 64 % of the total neutron exposure. As the distance from the field edge became larger, the external neutrons from the nozzle appear to dominate and the internal neutrons became less prominent. Conclusion: This study suggests that the contribution of internal neutrons could be significant to the total neutron dose equivalent.

  10. Proton Transport Chains in Glucose Metabolism: Mind the Proton

    Directory of Open Access Journals (Sweden)

    Dirk Roosterman

    2018-06-01

    Full Text Available The Embden–Meyerhof–Parnas (EMP pathway comprises eleven cytosolic enzymes interacting to metabolize glucose to lactic acid [CH3CH(OHCOOH]. Glycolysis is largely considered as the conversion of glucose to pyruvate (CH3COCOO-. We consider glycolysis to be a cellular process and as such, transporters mediating glucose uptake and lactic acid release and enable the flow of metabolites through the cell, must be considered as part of the EMP pathway. In this review, we consider the flow of metabolites to be coupled to a flow of energy that is irreversible and sufficient to form ordered structures. This latter principle is highlighted by discussing that lactate dehydrogenase (LDH complexes irreversibly reduce pyruvate/H+ to lactate [CH3CH(OHCOO-], or irreversibly catalyze the opposite reaction, oxidation of lactate to pyruvate/H+. However, both LDH complexes are considered to be driven by postulated proton transport chains. Metabolism of glucose to two lactic acids is introduced as a unidirectional, continuously flowing pathway. In an organism, cell membrane-located proton-linked monocarboxylate transporters catalyze the final step of glycolysis, the release of lactic acid. Consequently, both pyruvate and lactate are discussed as intermediate products of glycolysis and substrates of regulated crosscuts of the glycolytic flow.

  11. Fast pencil beam dose calculation for proton therapy using a double-Gaussian beam model

    Directory of Open Access Journals (Sweden)

    Joakim eda Silva

    2015-12-01

    Full Text Available The highly conformal dose distributions produced by scanned proton pencil beams are more sensitive to motion and anatomical changes than those produced by conventional radiotherapy. The ability to calculate the dose in real time as it is being delivered would enable, for example, online dose monitoring, and is therefore highly desirable. We have previously described an implementation of a pencil beam algorithm running on graphics processing units (GPUs intended specifically for online dose calculation. Here we present an extension to the dose calculation engine employing a double-Gaussian beam model to better account for the low-dose halo. To the best of our knowledge, it is the first such pencil beam algorithm for proton therapy running on a GPU. We employ two different parametrizations for the halo dose, one describing the distribution of secondary particles from nuclear interactions found in the literature and one relying on directly fitting the model to Monte Carlo simulations of pencil beams in water. Despite the large width of the halo contribution, we show how in either case the second Gaussian can be included whilst prolonging the calculation of the investigated plans by no more than 16%, or the calculation of the most time-consuming energy layers by about 25%. Further, the calculation time is relatively unaffected by the parametrization used, which suggests that these results should hold also for different systems. Finally, since the implementation is based on an algorithm employed by a commercial treatment planning system, it is expected that with adequate tuning, it should be able to reproduce the halo dose from a general beam line with sufficient accuracy.

  12. Divergence in intense ion beams caused by incomplete charge neutralization

    International Nuclear Information System (INIS)

    Olson, C.L.; Poukey, J.W.

    1993-01-01

    Space charge neutralization for light ion fusion (LIF) ion beam transport is usually assumed to be perfect in the open-quotes charge-neutralclose quotes region of the diode and in the gas transport cell. However, small charge clumps in the beam will not be totally charge-neutralized, and the residual net space charge may contribute to the beam microdivergence θ μ . If the net potential of the clump is limited only by electron trapping, the minimum potential will be eφ ∼ 1/2 m e v i 2 where m e is the electron mass and v i is the ion velocity. For proton beams this leads to θ μ ∼ (m e /M p ) 1/2 ∼ 23 mrad, where M p is the proton rest mass. For non-protonic beams, different results occur. The mechanism predicts (1) no dependence of θ μ on diode voltage, (2) non-protonic θ μ greater than proton θ μ for proton-contaminated beams, and (3) axial energy spread Δε parallel /ε parallel ∼ ±2 θ μ , which are all consistent with present data. Results of analytic studies and computer simulations of this mechanism are presented. Plasma shielding reduces the effects of this mechanism but collisions and magnetic fields reduce the plasma shielding effects. 2-D PIC MAGIC simulations show that this mechanism contributes to θ μ both in the open-quotes charge-neutralclose quotes region and in the gas transport region. It is concluded that this mechanism is especially important in the open-quotes charge-neutralclose quotes region

  13. Test facility of proton beam utilization of the PEFP at the SNU-AMS tandem accelerator

    International Nuclear Information System (INIS)

    Kim, K. R.; Park, B. S.; Lee, H. R.

    2004-01-01

    The PEFP (Proton Engineering Frontier Project) will supply users with a 20-MeV proton beam by the middle of 2007. A survey on users' demand was performed to draw the concept for the 20-MeV user facilities and to investigate users' requirements. In the mean time, a 6-MeV test facility has been developed to give users opportunities to experiment with proton beams. That facility will be attached to the 3-MV tandem accelerator at Seoul National University.

  14. Characterization of the proton beam from an IBA Cyclone 18/9 with radiochromic film EBT2

    Energy Technology Data Exchange (ETDEWEB)

    Sansaloni, F.; Lagares, J. I.; Arce, P.; Llop, J.; Perez, J. M. [Medical Applications Unit, Technology Department, CIEMAT, Madrid (Spain); Radiochemistry Department, Molecular Imaging unit, CIC-biomaGUNE, San Sebastian (Spain); Technology Department, CIEMAT (Spain)

    2012-12-19

    The use of radiochromic films is widespread in different areas of medical physics like radiotherapy and hadrontherapy; however, radiochromic films have been scarcely used in the characterization of proton or deuteron beams generated in biomedical cyclotrons. In this paper the radiochromic film EBT2 was used to study the beam size and the proton beam energy of an IBA Cyclone 18/9 cyclotron. The results indicate that the beam size can be easily measured at a very low expense; however, an accurate determination of the beam energy might require the implementation of certain experimental improvements.

  15. Testing proton spin models with polarized beams

    International Nuclear Information System (INIS)

    Ramsey, G.P.

    1991-01-01

    We review models for spin-weighted parton distributions in a proton. Sum rules involving the nonsinglet components of the structure function xg 1 p help narrow the range of parameters in these models. The contribution of the γ 5 anomaly term depends on the size of the integrated polarized gluon distribution and experimental predictions depend on its size. We have proposed three models for the polarized gluon distributions, whose range is considerable. These model distributions give an overall range is considerable. These model distributions give an overall range of parameters that can be tested with polarized beam experiments. These are discussed with regard to specific predictions for polarized beam experiments at energies typical of UNK

  16. TECHNOLOGIES FOR DELIVERY OF PROTON AND ION BEAMS FOR RADIOTHERAPY

    CERN Document Server

    Owen, H; Alonso, J; Mackay, R

    2014-01-01

    Recent developments for the delivery of proton and ion beam therapy have been significant, and a number of technological solutions now exist for the creation and utilisation of these particles for the treatment of cancer. In this paper we review the historical development of particle accelerators used for external beam radiotherapy and discuss the more recent progress towards more capable and cost-effective sources of particles.

  17. Proteomic analysis of proton beam irradiated human melanoma cells.

    Directory of Open Access Journals (Sweden)

    Sylwia Kedracka-Krok

    Full Text Available Proton beam irradiation is a form of advanced radiotherapy providing superior distributions of a low LET radiation dose relative to that of photon therapy for the treatment of cancer. Even though this clinical treatment has been developing for several decades, the proton radiobiology critical to the optimization of proton radiotherapy is far from being understood. Proteomic changes were analyzed in human melanoma cells treated with a sublethal dose (3 Gy of proton beam irradiation. The results were compared with untreated cells. Two-dimensional electrophoresis was performed with mass spectrometry to identify the proteins. At the dose of 3 Gy a minimal slowdown in proliferation rate was seen, as well as some DNA damage. After allowing time for damage repair, the proteomic analysis was performed. In total 17 protein levels were found to significantly (more than 1.5 times change: 4 downregulated and 13 upregulated. Functionally, they represent four categories: (i DNA repair and RNA regulation (VCP, MVP, STRAP, FAB-2, Lamine A/C, GAPDH, (ii cell survival and stress response (STRAP, MCM7, Annexin 7, MVP, Caprin-1, PDCD6, VCP, HSP70, (iii cell metabolism (TIM, GAPDH, VCP, and (iv cytoskeleton and motility (Moesin, Actinin 4, FAB-2, Vimentin, Annexin 7, Lamine A/C, Lamine B. A substantial decrease (2.3 x was seen in the level of vimentin, a marker of epithelial to mesenchymal transition and the metastatic properties of melanoma.

  18. Incorporating partial shining effects in proton pencil-beam dose calculation

    International Nuclear Information System (INIS)

    Li Yupeng; Zhang Xiaodong; Lii Mingfwu; Sahoo, Narayan; Zhu, Ron X; Gillin, Michael; Mohan, Radhe

    2008-01-01

    A range modulator wheel (RMW) is an essential component in passively scattered proton therapy. We have observed that a proton beam spot may shine on multiple steps of the RMW. Proton dose calculation algorithms normally do not consider the partial shining effect, and thus overestimate the dose at the proximal shoulder of spread-out Bragg peak (SOBP) compared with the measurement. If the SOBP is adjusted to better fit the plateau region, the entrance dose is likely to be underestimated. In this work, we developed an algorithm that can be used to model this effect and to allow for dose calculations that better fit the measured SOBP. First, a set of apparent modulator weights was calculated without considering partial shining. Next, protons spilled from the accelerator reaching the modulator wheel were simplified as a circular spot of uniform intensity. A weight-splitting process was then performed to generate a set of effective modulator weights with the partial shining effect incorporated. The SOBPs of eight options, which are used to label different combinations of proton-beam energy and scattering devices, were calculated with the generated effective weights. Our algorithm fitted the measured SOBP at the proximal and entrance regions much better than the ones without considering partial shining effect for all SOBPs of the eight options. In a prostate patient, we found that dose calculation without considering partial shining effect underestimated the femoral head and skin dose

  19. LATTICE/hor ellipsis/a beam transport program

    International Nuclear Information System (INIS)

    Staples, J.

    1987-06-01

    LATTICE is a computer program that calculates the first order characteristics of synchrotrons and beam transport systems. The program uses matrix algebra to calculate the propagation of the betatron (Twiss) parameters along a beam line. The program draws on ideas from several older programs, notably Transport and Synch, adds many new ones and incorporates them into an interactive, user-friendly program. LATTICE will calculate the matched functions of a synchrotron lattice and display them in a number of ways, including a high resolution Tektronix graphics display. An optimizer is included to adjust selected element parameters so the beam meets a set of constraints. LATTICE is a first order program, but the effect of sextupoles on the chromaticity of a synchrotron lattice is included, and the optimizer will set the sextupole strengths for zero chromaticity. The program will also calculate the characteristics of beam transport systems. In this mode, the beam parameters, defined at the start of the transport line, are propagated through to the end. LATTICE has two distinct modes: the lattice mode which finds the matched functions of a synchrotron, and the transport mode which propagates a predefined beam through a beam line. However, each mode can be used for either type of problem: the transport mode may be used to calculate an insertion for a synchrotron lattice, and the lattice mode may be used to calculate the characteristics of a long periodic beam transport system

  20. High-energy polarized proton beams a modern view

    CERN Document Server

    Hoffstaetter, Georg Heinz

    2006-01-01

    This monograph begins with a review of the basic equations of spin motion in particle accelerators. It then reviews how polarized protons can be accelerated to several tens of GeV using as examples the preaccelerators of HERA, a 6.3 km long cyclic accelerator at DESY / Hamburg. Such techniques have already been used at the AGS of BNL / New York, to accelerate polarized protons to 25 GeV. But for acceleration to energies of several hundred GeV as in RHIC, TEVATRON, HERA, LHC, or a VLHC, new problems can occur which can lead to a significantly diminished beam polarization. For these high energies, it is necessary to look in more detail at the spin motion, and for that the invariant spin field has proved to be a useful tool. This is already widely used for the description of high-energy electron beams that become polarized by the emission of spin-flip synchrotron radiation. It is shown that this field gives rise to an adiabatic invariant of spin-orbit motion and that it defines the maximum time average polarizat...

  1. Beam-induced and cosmic-ray backgrounds observed in the ATLAS detector during the LHC 2012 proton-proton running period

    International Nuclear Information System (INIS)

    Aad, G.; Abbott, B.; Abdallah, J.; Abdinov, O.; Abeloos, B.; Aben, R.; Abolins, M.; AbouZeid, O.S.; Abraham, N.L.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B.S.; Adamczyk, L.; Adams, D.L.; Adelman, J.

    2016-01-01

    This paper discusses various observations on beam-induced and cosmic-ray backgrounds in the ATLAS detector during the LHC 2012 proton-proton run. Building on published results based on 2011 data, the correlations between background and residual pressure of the beam vacuum are revisited. Ghost charge evolution over 2012 and its role for backgrounds are evaluated. New methods to monitor ghost charge with beam-gas rates are presented and observations of LHC abort gap population by ghost charge are discussed in detail. Fake jets from colliding bunches and from ghost charge are analysed with improved methods, showing that ghost charge in individual radio-frequency buckets of the LHC can be resolved. Some results of two short periods of dedicated cosmic-ray background data-taking are shown; in particular cosmic-ray muon induced fake jet rates are compared to Monte Carlo simulations and to the fake jet rates from beam background. A thorough analysis of a particular LHC fill, where abnormally high background was observed, is presented. Correlations between backgrounds and beam intensity losses in special fills with very high β * are studied.

  2. Fabrication of phosphor micro-grids using proton beam lithography

    International Nuclear Information System (INIS)

    Rossi, Paolo; Antolak, Arlyn J.; Provencio, Paula Polyak; Doyle, Barney Lee; Malmqvist, Klas; Hearne, Sean Joseph; Nilsson, Christer; Kristiansson, Per; Wegden, Marie; Elfman, Mikael; Pallon, Jan; Auzelyte, Vaida

    2005-01-01

    A new nuclear microscopy technique called ion photon emission microscopy or IPEM was recently invented. IPEM allows analysis involving single ions, such as ion beam induced charge (IBIC) or single event upset (SEU) imaging using a slightly modified optical microscope. The spatial resolution of IPEM is currently limited to more than 10 (micro)m by the scattering and reflection of ion-induced photons, i.e. light blooming or spreading, in the ionoluminescent phosphor layer. We are developing a 'Microscopic Gridded Phosphor' (also called Black Matrix) where the phosphor nanocrystals are confined within the gaps of a micrometer scale opaque grid, which limits the amount of detrimental light blooming. MeV-energy proton beam lithography is ideally suited to lithographically form masks for the grid because of high aspect ratio, pattern density and sub-micron resolution of this technique. In brief, the fabrication of the grids was made in the following manner: (1) a MeV proton beam focused to 1.5-2 (micro)m directly fabricated a matrix of pillars in a 15 (micro)m thick SU-8 lithographic resist; (2) 7:1 aspect ratio pillars were then formed by developing the proton exposed area; (3) Ni (Au) was electrochemically deposited onto Cu-coated Si from a sulfamate bath (or buffered CN bath); (4) the SU-8 pillars were removed by chemical etching; finally (5) the metal micro-grid was freed from its substrate by etching the underlying Cu layer. Our proposed metal micro-grids promise an order-of-magnitude improvement in the resolution of IPEM.

  3. The solenoidal transport option: IFE drivers, near term research facilities, and beam dynamics

    International Nuclear Information System (INIS)

    Lee, E.P.; Briggs, R.J.

    1997-09-01

    Solenoidal magnets have been used as the beam transport system in all the high current electron induction accelerators that have been built in the past several decades. They have also been considered for the front end transport system for heavy ion accelerators for Inertial Fusion Energy (IFE) drivers, but this option has received very little attention in recent years. The analysis reported here was stimulated mainly by the recent effort to define an affordable open-quotes Integrated Research Experimentclose quotes (IRE) that can meet the near term needs of the IFE program. The 1996 FESAC IFE review panel agreed that an integrated experiment is needed to fully resolve IFE heavy ion driver science and technology issues; specifically, open-quotes the basic beam dynamics issues in the accelerator, the final focusing and transport issues in a reactor-relevant beam parameter regime, and the target heating phenomenologyclose quotes. The development of concepts that can meet these technical objectives and still stay within the severe cost constraints all new fusion proposals will encounter is a formidable challenge. Solenoidal transport has a very favorable scaling as the particle mass is decreased (the main reason why it is preferred for electrons in the region below 50 MeV). This was recognized in a recent conceptual study of high intensity induction linac-based proton accelerators for Accelerator Driven Transmutation Technologies, where solenoidal transport was chosen for the front end. Reducing the ion mass is an obvious scaling to exploit in an IRE design, since the output beam voltage will necessarily be much lower than that of a full scale driver, so solenoids should certainly be considered as one option for this experiment as well

  4. A study on the proton beam energy(50 MeV) measurement and diagnosis (II)

    Energy Technology Data Exchange (ETDEWEB)

    Chae, Jong Suh; Lee, Dong Hoon; Kim, Yoo Suk; Park, Chan Won; Lee, Yong Min; Hong, Sung Suk; Lee, Min Yong; Lee, Ji Sub; Hah, Hang Hoh [Korea Cancer Center Hospital of Korea Atomic Energy Research Institute, Seoul (Korea, Republic of)

    1995-02-01

    The main purpose of this project is the precise ion measurement of proton beam energy extracted at RF 25.89 MHz from the MC-50 cyclotron of SF type. There are several method for particle energy measurement. We measured the 50 MeV proton energy by using the E-{Delta}E method in 1993. And also in our experiment used range, reapproval of energy of extracted proton beam at RF 25.89 MHz was performed, which attained the same energy with the result used elastic scattering within the error range. 10 figs, 2 pix, 3 tabs, 3 refs. (Author).

  5. Beam Loss Calibration Studies for High Energy Proton Accelerators

    CERN Document Server

    Stockner, M

    2007-01-01

    CERN's Large Hadron Collider (LHC) is a proton collider with injection energy of 450 GeV and collision energy of 7 TeV. Superconducting magnets keep the particles circulating in two counter rotating beams, which cross each other at the Interaction Points (IP). Those complex magnets have been designed to contain both beams in one yoke within a cryostat. An unprecedented amount of energy will be stored in the circulating beams and in the magnet system. The LHC outperforms other existing accelerators in its maximum beam energy by a factor of 7 and in its beam intensity by a factor of 23. Even a loss of a small fraction of the beam particles may cause the transition from the superconducting to the normal conducting state of the coil or cause physical damage to machine components. The unique combination of these extreme beam parameters and the highly advanced superconducting technology has the consequence that the LHC needs a more efficient beam cleaning and beam loss measurement system than previous accelerators....

  6. Simulation study on beam loss in the alpha bucket regime during SIS-100 proton operation

    Science.gov (United States)

    Sorge, S.

    2018-02-01

    Crossing the transition energy γt in synchrotrons for high intensity proton beams requires well tuned jump schemes and is usually accompanied by longitudinal emittance growth. In order to avoid γt crossing during proton operation in the projected SIS-100 synchrotron special high-γt lattice settings have been developed, in order to keep γt above the beam extraction energy. A further advantage of this scheme is the formation of alpha buckets which naturally lead to short proton bunches, required for the foreseen production and storage of antiprotons for the FAIR facility. Special attention is turned on the imperfections of the superconducting SIS-100 magnets because together with the high-γt lattice settings, they could potentially lead to enhanced beam loss. The aim of the present work is to estimate the beam loss by means of particle tracking simulations.

  7. Simulation studies of macroparticles falling into the LHC Proton Beam

    CERN Document Server

    Fuster Martinez, N; Zimmermann, F; Baer, T; Giovannozzi, M; Holzer, E B; Nebot Del Busto, E; Nordt, A; Sapinski, M; Yang, Z

    2011-01-01

    We report updated simulations on the interaction of macroparticles falling from the top of the vacuum chamber into the circulating LHC proton beam. The path and charge state of micron size micro-particles are computed together with the resulting beam losses, which — if high enough — can lead to the local quench of superconducting (SC) magnets. The simulated time evolution of the beam loss is compared with observations in order to constrain some macroparticle parameters. We also discuss the possibility of a “multiple crossing” by the same macroparticle, the effect of a strong dipole field, and the dependence of peak loss rate and loss duration on beam current and on beam size.

  8. Technical Note: Spot characteristic stability for proton pencil beam scanning

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chin-Cheng, E-mail: chen.ccc@gmail.com; Chang, Chang; Mah, Dennis [ProCure Treatment Center, Somerset, New Jersey 08873 (United States); Moyers, Michael F. [ProCure Treatment Center, Somerset, New Jersey 08873 and Shanghai Proton and Heavy Ion Center, Shanghai 201321 (China); Gao, Mingcheng [CDH Proton Center, Warrenville, Illinois 60555 (United States)

    2016-02-15

    Purpose: The spot characteristics for proton pencil beam scanning (PBS) were measured and analyzed over a 16 month period, which included one major site configuration update and six cyclotron interventions. The results provide a reference to establish the quality assurance (QA) frequency and tolerance for proton pencil beam scanning. Methods: A simple treatment plan was generated to produce an asymmetric 9-spot pattern distributed throughout a field of 16 × 18 cm for each of 18 proton energies (100.0–226.0 MeV). The delivered fluence distribution in air was measured using a phosphor screen based CCD camera at three planes perpendicular to the beam line axis (x-ray imaging isocenter and up/down stream 15.0 cm). The measured fluence distributions for each energy were analyzed using in-house programs which calculated the spot sizes and positional deviations of the Gaussian shaped spots. Results: Compared to the spot characteristic data installed into the treatment planning system, the 16-month averaged deviations of the measured spot sizes at the isocenter plane were 2.30% and 1.38% in the IEC gantry x and y directions, respectively. The maximum deviation was 12.87% while the minimum deviation was 0.003%, both at the upstream plane. After the collinearity of the proton and x-ray imaging system isocenters was optimized, the positional deviations of the spots were all within 1.5 mm for all three planes. During the site configuration update, spot positions were found to deviate by 6 mm until the tuning parameters file was properly restored. Conclusions: For this beam delivery system, it is recommended to perform a spot size and position check at least monthly and any time after a database update or cyclotron intervention occurs. A spot size deviation tolerance of <15% can be easily met with this delivery system. Deviations of spot positions were <2 mm at any plane up/down stream 15 cm from the isocenter.

  9. Technical Note: Spot characteristic stability for proton pencil beam scanning

    International Nuclear Information System (INIS)

    Chen, Chin-Cheng; Chang, Chang; Mah, Dennis; Moyers, Michael F.; Gao, Mingcheng

    2016-01-01

    Purpose: The spot characteristics for proton pencil beam scanning (PBS) were measured and analyzed over a 16 month period, which included one major site configuration update and six cyclotron interventions. The results provide a reference to establish the quality assurance (QA) frequency and tolerance for proton pencil beam scanning. Methods: A simple treatment plan was generated to produce an asymmetric 9-spot pattern distributed throughout a field of 16 × 18 cm for each of 18 proton energies (100.0–226.0 MeV). The delivered fluence distribution in air was measured using a phosphor screen based CCD camera at three planes perpendicular to the beam line axis (x-ray imaging isocenter and up/down stream 15.0 cm). The measured fluence distributions for each energy were analyzed using in-house programs which calculated the spot sizes and positional deviations of the Gaussian shaped spots. Results: Compared to the spot characteristic data installed into the treatment planning system, the 16-month averaged deviations of the measured spot sizes at the isocenter plane were 2.30% and 1.38% in the IEC gantry x and y directions, respectively. The maximum deviation was 12.87% while the minimum deviation was 0.003%, both at the upstream plane. After the collinearity of the proton and x-ray imaging system isocenters was optimized, the positional deviations of the spots were all within 1.5 mm for all three planes. During the site configuration update, spot positions were found to deviate by 6 mm until the tuning parameters file was properly restored. Conclusions: For this beam delivery system, it is recommended to perform a spot size and position check at least monthly and any time after a database update or cyclotron intervention occurs. A spot size deviation tolerance of <15% can be easily met with this delivery system. Deviations of spot positions were <2 mm at any plane up/down stream 15 cm from the isocenter

  10. Selective Adsorption of Nano-bio materials and nanostructure fabrication on Molecular Resists Modified by proton beam irradiation

    International Nuclear Information System (INIS)

    Lee, H. W.; Kim, H. S.; Kim, S. M.

    2008-04-01

    The purpose of this research is the fabrication of nanostructures on silicon substrate using proton beam and selectively adsorption of bio-nano materials on the patterned substrate. Recently, the miniaturization of the integrated devices with fine functional structures was intensively investigated, based on combination of nanotechnology (NT), biotechnology (BT) and information technology (IT). Because of the inherent limitation in optical lithography, large variety of novel patterning technologies were evolved to construct nano-structures onto a substrate. Atomic force microscope-based nanolithography has readily formed sub-50 nm patterns by the local modification of a substrate using a probe with a curvature of 10 nm. The surface property was regarded as one of the most important factors for AFM-based nanolithography as well as for other novel nanolithographies. The molecular thin films such as a self-assembled monolayer or a polymer resist layer have been used as an alternative to modifying the surface property. Although proton or ion beam irradiation has been used as an efficient tool to modify the physical, chemical and electrical properties of a surface, the nano-patterning on the substrate or the molecular film modified with the beam irradiation has hardly been studied at both home and abroad. The selective adsorption of nano-bio materials such as carbon nanotubes and proteins on the patterns would contribute to developing the integrated devices. The polystyrene nanoparticles (400 nm) were arrayed on al silicon surface using nanosphere lithography and the various nanopatterns were fabricated by proton beam irradiation on the polystyrene nanoparticles arrayed silicon surface. We obtained the two different nanopatterns such as polymer nanoring patterns and silicon oxide patterns on the same silicon substrate. The polymer nanoring patterns formed by the crosslinkage of polystyrene when proton beam was irradiated at the triangular void spaces that are enclosed by

  11. Design study of the ESS-Bilbao 50 MeV proton beam line for radiobiological studies

    Energy Technology Data Exchange (ETDEWEB)

    Huerta-Parajon, M., E-mail: mhuerta@essbilbao.org; Martinez-Ballarin, R., E-mail: rmartinez@essbilbao.org; Abad, E., E-mail: eabad@essbilbao.org

    2015-02-01

    The ESS-Bilbao proton accelerator facility has been designed fulfilling the European Spallation Source (ESS) specifications to serve as the Spanish contribution to the ESS construction. Furthermore, several applications of the ESS-Bilbao proton beam are being considered in order to contribute to the knowledge in the field of radiobiology, materials and aerospace components. Understanding of the interaction of radiation with biological systems is of vital importance as it affects important applications such as cancer treatment with ion beam therapy among others. ESS-Bilbao plans to house a facility exclusively dedicated to radiobiological experiments with protons up to 50 MeV. Beam line design, optimisation and initial calculations of flux densities and absorbed doses were undertaken using the Monte Carlo simulation package FLUKA. A proton beam with a flux density of about 10{sup 6} protons/cm{sup 2} s reaches the water sample with a flat lateral distribution of the dose. The absorbed dose at the pristine Bragg peak calculated with FLUKA is 2.4 ± 0.1 Gy in 1 min of irradiation time. This value agrees with the clinically meaningful dose rates, i.e. around 2 Gy/min, used in hadrontherapy. Optimisation and validation studies in the ESS-Bilbao line for radiobiological experiments are detailed in this article.

  12. Beam-induced and cosmic-ray backgrounds observed in the ATLAS detector during the LHC 2012 proton-proton running period

    CERN Document Server

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Havranek, Miroslav; Hawkes, Christopher; Hawkings, Richard John; Hawkins, Anthony David; Hayden, Daniel; Hays, Chris; Hays, Jonathan Michael; Hayward, Helen; Haywood, Stephen; Head, Simon; Heck, Tobias; Hedberg, Vincent; Heelan, Louise; Heim, Sarah; Heim, Timon; Heinemann, Beate; Heinrich, Jochen Jens; Heinrich, Lukas; Heinz, Christian; Hejbal, Jiri; Helary, Louis; Hellman, Sten; Helsens, Clement; Henderson, James; Henderson, Robert; Heng, Yang; Henkelmann, Steffen; Henriques Correia, Ana Maria; Henrot-Versille, Sophie; Herbert, Geoffrey Henry; Hernández Jiménez, Yesenia; Herten, Gregor; Hertenberger, Ralf; Hervas, Luis; Hesketh, Gavin Grant; Hessey, Nigel; Hetherly, Jeffrey Wayne; Hickling, Robert; Higón-Rodriguez, Emilio; Hill, Ewan; Hill, John; Hiller, Karl Heinz; Hillier, Stephen; Hinchliffe, Ian; Hines, Elizabeth; Hinman, Rachel Reisner; Hirose, Minoru; Hirschbuehl, Dominic; Hobbs, John; Hod, Noam; Hodgkinson, Mark; Hodgson, Paul; Hoecker, Andreas; Hoeferkamp, Martin; Hoenig, Friedrich; Hohlfeld, Marc; Hohn, David; Holmes, Tova Ray; Homann, Michael; Hong, Tae Min; Hooberman, Benjamin Henry; Hopkins, Walter; Horii, Yasuyuki; Horton, Arthur James; Hostachy, Jean-Yves; Hou, Suen; Hoummada, Abdeslam; Howard, Jacob; Howarth, James; Hrabovsky, Miroslav; Hristova, Ivana; Hrivnac, Julius; Hryn'ova, Tetiana; Hrynevich, Aliaksei; Hsu, Catherine; Hsu, Pai-hsien Jennifer; Hsu, Shih-Chieh; Hu, Diedi; Hu, Qipeng; Huang, Yanping; Hubacek, Zdenek; Hubaut, Fabrice; Huegging, Fabian; Huffman, Todd Brian; Hughes, Emlyn; Hughes, Gareth; Huhtinen, Mika; Hülsing, Tobias Alexander; Huseynov, Nazim; Huston, Joey; Huth, John; Iacobucci, Giuseppe; Iakovidis, Georgios; Ibragimov, Iskander; Iconomidou-Fayard, Lydia; Ideal, Emma; Idrissi, Zineb; Iengo, Paolo; Igonkina, Olga; Iizawa, Tomoya; Ikegami, Yoichi; Ikeno, Masahiro; Ilchenko, Iurii; Iliadis, Dimitrios; Ilic, Nikolina; Ince, Tayfun; Introzzi, Gianluca; Ioannou, Pavlos; Iodice, Mauro; Iordanidou, Kalliopi; Ippolito, Valerio; Irles Quiles, Adrian; Isaksson, Charlie; Ishino, Masaya; Ishitsuka, Masaki; Ishmukhametov, Renat; Issever, Cigdem; Istin, Serhat; Ito, Fumiaki; Iturbe Ponce, Julia Mariana; Iuppa, Roberto; Ivarsson, Jenny; Iwanski, Wieslaw; Iwasaki, Hiroyuki; Izen, Joseph; Izzo, Vincenzo; Jabbar, Samina; Jackson, Brett; Jackson, Matthew; Jackson, Paul; Jain, Vivek; Jakobi, Katharina Bianca; Jakobs, Karl; Jakobsen, Sune; Jakoubek, Tomas; Jamin, David Olivier; Jana, Dilip; Jansen, Eric; Jansky, Roland; Janssen, Jens; Janus, Michel; Jarlskog, Göran; Javadov, Namig; Javůrek, Tomáš; Jeanneau, Fabien; Jeanty, Laura; Jejelava, Juansher; Jeng, Geng-yuan; Jennens, David; Jenni, Peter; Jentzsch, Jennifer; Jeske, Carl; Jézéquel, Stéphane; Ji, Haoshuang; Jia, Jiangyong; Jiang, Hai; Jiang, Yi; Jiggins, Stephen; Jimenez Pena, Javier; Jin, Shan; Jinaru, Adam; Jinnouchi, Osamu; Johansson, Per; Johns, Kenneth; Johnson, William Joseph; Jon-And, Kerstin; Jones, Graham; Jones, Roger; Jones, Sarah; Jones, Tim; Jongmanns, Jan; Jorge, Pedro; Jovicevic, Jelena; Ju, Xiangyang; Juste Rozas, Aurelio; Köhler, Markus Konrad; Kaczmarska, Anna; Kado, Marumi; Kagan, Harris; Kagan, Michael; Kahn, Sebastien Jonathan; Kajomovitz, Enrique; Kalderon, Charles William; Kaluza, Adam; Kama, Sami; Kamenshchikov, Andrey; Kanaya, Naoko; Kaneti, Steven; Kantserov, Vadim; Kanzaki, Junichi; Kaplan, Benjamin; Kaplan, Laser Seymour; Kapliy, Anton; Kar, Deepak; Karakostas, Konstantinos; Karamaoun, Andrew; Karastathis, Nikolaos; Kareem, Mohammad Jawad; Karentzos, Efstathios; Karnevskiy, Mikhail; Karpov, Sergey; Karpova, Zoya; Karthik, Krishnaiyengar; Kartvelishvili, Vakhtang; Karyukhin, Andrey; Kasahara, Kota; Kashif, Lashkar; Kass, Richard; Kastanas, Alex; Kataoka, Yousuke; Kato, Chikuma; Katre, Akshay; Katzy, Judith; Kawagoe, Kiyotomo; Kawamoto, Tatsuo; Kawamura, Gen; Kazama, Shingo; Kazanin, Vassili; Keeler, Richard; Kehoe, Robert; Keller, John; Kempster, Jacob Julian; Kentaro, Kawade; Keoshkerian, Houry; Kepka, Oldrich; Kerševan, Borut Paul; Kersten, Susanne; Keyes, Robert; Khalil-zada, Farkhad; Khandanyan, Hovhannes; Khanov, Alexander; Kharlamov, Alexey; Khoo, Teng Jian; Khovanskiy, Valery; Khramov, Evgeniy; Khubua, Jemal; Kido, Shogo; Kim, Hee Yeun; Kim, Shinhong; Kim, Young-Kee; Kimura, Naoki; Kind, Oliver Maria; King, Barry; King, Matthew; King, Samuel Burton; Kirk, Julie; Kiryunin, Andrey; Kishimoto, Tomoe; Kisielewska, Danuta; Kiss, Florian; Kiuchi, Kenji; Kivernyk, Oleh; Kladiva, Eduard; Klein, Matthew Henry; Klein, Max; Klein, Uta; Kleinknecht, Konrad; Klimek, Pawel; Klimentov, Alexei; Klingenberg, Reiner; Klinger, Joel Alexander; Klioutchnikova, Tatiana; Kluge, Eike-Erik; Kluit, Peter; Kluth, Stefan; Knapik, Joanna; Kneringer, Emmerich; Knoops, Edith; Knue, Andrea; Kobayashi, Aine; Kobayashi, Dai; Kobayashi, Tomio; Kobel, Michael; Kocian, Martin; Kodys, Peter; Koffas, Thomas; Koffeman, Els; Kogan, Lucy Anne; Koi, Tatsumi; Kolanoski, Hermann; Kolb, Mathis; Koletsou, Iro; Komar, Aston; Komori, Yuto; Kondo, Takahiko; Kondrashova, Nataliia; Köneke, Karsten; König, Adriaan; Kono, Takanori; Konoplich, Rostislav; Konstantinidis, Nikolaos; Kopeliansky, Revital; Koperny, Stefan; Köpke, Lutz; Kopp, Anna Katharina; Korcyl, Krzysztof; Kordas, Kostantinos; Korn, Andreas; Korol, Aleksandr; Korolkov, Ilya; Korolkova, Elena; Kortner, Oliver; Kortner, Sandra; Kosek, Tomas; Kostyukhin, Vadim; Kotwal, Ashutosh; Kourkoumeli-Charalampidi, Athina; Kourkoumelis, Christine; Kouskoura, Vasiliki; Koutsman, Alex; Kowalewska, Anna Bozena; Kowalewski, Robert Victor; Kowalski, Tadeusz; Kozanecki, Witold; Kozhin, Anatoly; Kramarenko, Viktor; Kramberger, Gregor; Krasnopevtsev, Dimitriy; Krasny, Mieczyslaw Witold; Krasznahorkay, Attila; Kraus, Jana; Kravchenko, Anton; Kretz, Moritz; Kretzschmar, Jan; Kreutzfeldt, Kristof; Krieger, Peter; Krizka, Karol; Kroeninger, Kevin; Kroha, Hubert; Kroll, Joe; Kroseberg, Juergen; Krstic, Jelena; Kruchonak, Uladzimir; Krüger, Hans; Krumnack, Nils; Kruse, Amanda; Kruse, Mark; Kruskal, Michael; Kubota, Takashi; Kucuk, Hilal; Kuday, Sinan; Kuechler, Jan Thomas; Kuehn, Susanne; Kugel, Andreas; Kuger, Fabian; Kuhl, Andrew; Kuhl, Thorsten; Kukhtin, Victor; Kukla, Romain; Kulchitsky, Yuri; Kuleshov, Sergey; Kuna, Marine; Kunigo, Takuto; Kupco, Alexander; Kurashige, Hisaya; Kurochkin, Yurii; Kus, Vlastimil; Kuwertz, Emma Sian; Kuze, Masahiro; Kvita, Jiri; Kwan, Tony; Kyriazopoulos, Dimitrios; La Rosa, Alessandro; La Rosa Navarro, Jose Luis; La Rotonda, Laura; Lacasta, Carlos; Lacava, Francesco; Lacey, James; Lacker, Heiko; Lacour, Didier; Lacuesta, Vicente Ramón; Ladygin, Evgueni; Lafaye, Remi; Laforge, Bertrand; Lagouri, Theodota; Lai, Stanley; Lammers, Sabine; Lampl, Walter; Lançon, Eric; Landgraf, Ulrich; Landon, Murrough; Lang, Valerie Susanne; Lange, J örn Christian; Lankford, Andrew; Lanni, Francesco; Lantzsch, Kerstin; Lanza, Agostino; Laplace, Sandrine; Lapoire, Cecile; Laporte, Jean-Francois; Lari, Tommaso; Lasagni Manghi, Federico; Lassnig, Mario; Laurelli, Paolo; Lavrijsen, Wim; Law, Alexander; Laycock, Paul; Lazovich, Tomo; Lazzaroni, Massimo; Le Dortz, Olivier; Le Guirriec, Emmanuel; Le Menedeu, Eve; Le Quilleuc, Eloi; LeBlanc, Matthew Edgar; LeCompte, Thomas; Ledroit-Guillon, Fabienne Agnes Marie; Lee, Claire Alexandra; Lee, Shih-Chang; Lee, Lawrence; Lefebvre, Guillaume; Lefebvre, Michel; Legger, Federica; Leggett, Charles; Lehan, Allan; Lehmann Miotto, Giovanna; Lei, Xiaowen; Leight, William Axel; Leisos, Antonios; Leister, Andrew Gerard; Leite, Marco Aurelio Lisboa; Leitner, Rupert; Lellouch, Daniel; Lemmer, Boris; Leney, Katharine; Lenz, Tatjana; Lenzi, Bruno; Leone, Robert; Leone, Sandra; Leonidopoulos, Christos; Leontsinis, Stefanos; Lerner, Giuseppe; Leroy, Claude; Lesage, Arthur; Lester, Christopher; Levchenko, Mikhail; Levêque, Jessica; Levin, Daniel; Levinson, Lorne; Levy, Mark; Leyko, Agnieszka; Leyton, Michael; Li, Bing; Li, Haifeng; Li, Ho Ling; Li, Lei; Li, Liang; Li, Qi; Li, Shu; Li, Xingguo; Li, Yichen; Liang, Zhijun; Liao, Hongbo; Liberti, Barbara; Liblong, Aaron; Lichard, Peter; Lie, Ki; Liebal, Jessica; Liebig, Wolfgang; Limbach, Christian; Limosani, Antonio; Lin, Simon; Lin, Tai-Hua; Lindquist, Brian Edward; Lipeles, Elliot; Lipniacka, Anna; Lisovyi, Mykhailo; Liss, Tony; Lissauer, David; Lister, Alison; Litke, Alan; Liu, Bo; Liu, Dong; Liu, Hao; Liu, Hongbin; Liu, Jian; Liu, Jianbei; Liu, Kun; Liu, Lulu; Liu, Miaoyuan; Liu, Minghui; Liu, Yanlin; Liu, Yanwen; Livan, Michele; Lleres, Annick; Llorente Merino, Javier; Lloyd, Stephen; Lo Sterzo, Francesco; Lobodzinska, Ewelina; Loch, Peter; Lockman, William; Loebinger, Fred; Loevschall-Jensen, Ask Emil; Loew, Kevin Michael; Loginov, Andrey; Lohse, Thomas; Lohwasser, Kristin; Lokajicek, Milos; Long, Brian Alexander; Long, Jonathan David; Long, Robin Eamonn; Longo, Luigi; Looper, Kristina Anne; Lopes, Lourenco; Lopez Mateos, David; Lopez Paredes, Brais; Lopez Paz, Ivan; Lopez Solis, Alvaro; Lorenz, Jeanette; Lorenzo Martinez, Narei; Losada, Marta; Lösel, Philipp Jonathan; Lou, XinChou; Lounis, Abdenour; Love, Jeremy; Love, Peter; Lu, Haonan; Lu, Nan; Lubatti, Henry; Luci, Claudio; Lucotte, Arnaud; Luedtke, Christian; Luehring, Frederick; Lukas, Wolfgang; Luminari, Lamberto; Lundberg, Olof; Lund-Jensen, Bengt; Lynn, David; Lysak, Roman; Lytken, Else; Lyubushkin, Vladimir; Ma, Hong; Ma, Lian Liang; Ma, Yanhui; Maccarrone, Giovanni; Macchiolo, Anna; Macdonald, Calum Michael; Maček, Boštjan; Machado Miguens, Joana; Madaffari, Daniele; Madar, Romain; Maddocks, Harvey Jonathan; Mader, Wolfgang; Madsen, Alexander; Maeda, Junpei; Maeland, Steffen; Maeno, Tadashi; Maevskiy, Artem; Magradze, Erekle; Mahlstedt, Joern; Maiani, Camilla; Maidantchik, Carmen; Maier, Andreas Alexander; Maier, Thomas; Maio, Amélia; Majewski, Stephanie; Makida, Yasuhiro; Makovec, Nikola; Malaescu, Bogdan; Malecki, Pawel; Maleev, Victor; Malek, Fairouz; Mallik, Usha; Malon, David; Malone, Caitlin; Maltezos, Stavros; Malyukov, Sergei; Mamuzic, Judita; Mancini, Giada; Mandelli, Beatrice; Mandelli, Luciano; Mandić, Igor; Maneira, José; Manhaes de Andrade Filho, Luciano; Manjarres Ramos, Joany; Mann, Alexander; Mansoulie, Bruno; Mantifel, Rodger; Mantoani, Matteo; Manzoni, Stefano; Mapelli, Livio; Marceca, Gino; March, Luis; Marchiori, Giovanni; Marcisovsky, Michal; Marjanovic, Marija; Marley, Daniel; Marroquim, Fernando; Marsden, Stephen Philip; Marshall, Zach; Marti, Lukas Fritz; Marti-Garcia, Salvador; Martin, Brian Thomas; Martin, Tim; Martin, Victoria Jane; Martin dit Latour, Bertrand; Martinez, Mario; Martin-Haugh, Stewart; Martoiu, Victor Sorin; Martyniuk, Alex; Marx, Marilyn; Marzano, Francesco; Marzin, Antoine; Masetti, Lucia; Mashimo, Tetsuro; Mashinistov, Ruslan; Masik, Jiri; Maslennikov, Alexey; Massa, Ignazio; Massa, Lorenzo; Mastrandrea, Paolo; Mastroberardino, Anna; Masubuchi, Tatsuya; Mättig, Peter; Mattmann, Johannes; Maurer, Julien; Maxfield, Stephen; Maximov, Dmitriy; Mazini, Rachid; Mazza, Simone Michele; Mc Fadden, Neil Christopher; Mc Goldrick, Garrin; Mc Kee, Shawn Patrick; McCarn, Allison; McCarthy, Robert; McCarthy, Tom; McClymont, Laurie; McFarlane, Kenneth; Mcfayden, Josh; Mchedlidze, Gvantsa; McMahon, Steve; McPherson, Robert; Medinnis, Michael; Meehan, Samuel; Mehlhase, Sascha; Mehta, Andrew; Meier, Karlheinz; Meineck, Christian; Meirose, Bernhard; Mellado Garcia, Bruce Rafael; Meloni, Federico; Mengarelli, Alberto; Menke, Sven; Meoni, Evelin; Mercurio, Kevin Michael; Mergelmeyer, Sebastian; Mermod, Philippe; Merola, Leonardo; Meroni, Chiara; Merritt, Frank; Messina, Andrea; Metcalfe, Jessica; Mete, Alaettin Serhan; Meyer, Carsten; Meyer, Christopher; Meyer, Jean-Pierre; Meyer, Jochen; Meyer Zu Theenhausen, Hanno; Middleton, Robin; Miglioranzi, Silvia; Mijović, Liza; Mikenberg, Giora; Mikestikova, Marcela; Mikuž, Marko; Milesi, Marco; Milic, Adriana; Miller, David; Mills, Corrinne; Milov, Alexander; Milstead, David; Minaenko, Andrey; Minami, Yuto; Minashvili, Irakli; Mincer, Allen; Mindur, Bartosz; Mineev, Mikhail; Ming, Yao; Mir, Lluisa-Maria; Mistry, Khilesh; Mitani, Takashi; Mitrevski, Jovan; Mitsou, Vasiliki A; Miucci, Antonio; Miyagawa, Paul; Mjörnmark, Jan-Ulf; Moa, Torbjoern; Mochizuki, Kazuya; Mohapatra, Soumya; Mohr, Wolfgang; Molander, Simon; Moles-Valls, Regina; Monden, Ryutaro; Mondragon, Matthew Craig; Mönig, Klaus; Monk, James; Monnier, Emmanuel; Montalbano, Alyssa; Montejo Berlingen, Javier; Monticelli, Fernando; Monzani, Simone; Moore, Roger; Morange, Nicolas; Moreno, Deywis; Moreno Llácer, María; Morettini, Paolo; Mori, Daniel; Mori, Tatsuya; Morii, Masahiro; Morinaga, Masahiro; Morisbak, Vanja; Moritz, Sebastian; Morley, Anthony Keith; Mornacchi, Giuseppe; Morris, John; Mortensen, Simon Stark; Morvaj, Ljiljana; Mosidze, Maia; Moss, Josh; Motohashi, Kazuki; Mount, Richard; Mountricha, Eleni; Mouraviev, Sergei; Moyse, Edward; Muanza, Steve; Mudd, Richard; Mueller, Felix; Mueller, James; Mueller, Ralph Soeren Peter; Mueller, Thibaut; Muenstermann, Daniel; Mullen, Paul; Mullier, Geoffrey; Munoz Sanchez, Francisca Javiela; Murillo Quijada, Javier Alberto; Murray, Bill; Musheghyan, Haykuhi; Muskinja, Miha; Myagkov, Alexey; Myska, Miroslav; Nachman, Benjamin Philip; Nackenhorst, Olaf; Nadal, Jordi; Nagai, Koichi; Nagai, Ryo; Nagano, Kunihiro; Nagasaka, Yasushi; Nagata, Kazuki; Nagel, Martin; Nagy, Elemer; Nairz, Armin Michael; Nakahama, Yu; Nakamura, Koji; Nakamura, Tomoaki; Nakano, Itsuo; Namasivayam, Harisankar; Naranjo Garcia, Roger Felipe; Narayan, Rohin; Narrias Villar, Daniel Isaac; Naryshkin, Iouri; Naumann, Thomas; Navarro, Gabriela; Nayyar, Ruchika; Neal, Homer; Nechaeva, Polina; Neep, Thomas James; Nef, Pascal Daniel; Negri, Andrea; Negrini, Matteo; Nektarijevic, Snezana; Nellist, Clara; Nelson, Andrew; Nemecek, Stanislav; Nemethy, Peter; Nepomuceno, Andre Asevedo; Nessi, Marzio; Neubauer, Mark; Neumann, Manuel; Neves, Ricardo; Nevski, Pavel; Newman, Paul; Nguyen, Duong Hai; Nickerson, Richard; Nicolaidou, Rosy; Nicquevert, Bertrand; Nielsen, Jason; Nikiforov, Andriy; Nikolaenko, Vladimir; Nikolic-Audit, Irena; Nikolopoulos, Konstantinos; Nilsen, Jon Kerr; Nilsson, Paul; Ninomiya, Yoichi; Nisati, Aleandro; Nisius, Richard; Nobe, Takuya; Nodulman, Lawrence; Nomachi, Masaharu; Nomidis, Ioannis; Nooney, Tamsin; Norberg, Scarlet; Nordberg, Markus; Norjoharuddeen, Nurfikri; Novgorodova, Olga; Nowak, Sebastian; Nozaki, Mitsuaki; Nozka, Libor; Ntekas, Konstantinos; Nurse, Emily; Nuti, Francesco; O'grady, Fionnbarr; O'Neil, Dugan; O'Rourke, Abigail Alexandra; O'Shea, Val; Oakham, Gerald; Oberlack, Horst; Obermann, Theresa; Ocariz, Jose; Ochi, Atsuhiko; Ochoa, Ines; Ochoa-Ricoux, Juan Pedro; Oda, Susumu; Odaka, Shigeru; Ogren, Harold; Oh, Alexander; Oh, Seog; Ohm, Christian; Ohman, Henrik; Oide, Hideyuki; Okawa, Hideki; Okumura, Yasuyuki; Okuyama, Toyonobu; Olariu, Albert; Oleiro Seabra, Luis Filipe; Olivares Pino, Sebastian Andres; Oliveira Damazio, Denis; Olszewski, Andrzej; Olszowska, Jolanta; Onofre, António; Onogi, Kouta; Onyisi, Peter; Oram, Christopher; Oreglia, Mark; Oren, Yona; Orestano, Domizia; Orlando, Nicola; Orr, Robert; Osculati, Bianca; Ospanov, Rustem; Otero y Garzon, Gustavo; Otono, Hidetoshi; Ouchrif, Mohamed; Ould-Saada, Farid; Ouraou, Ahmimed; Oussoren, Koen Pieter; Ouyang, Qun; Ovcharova, Ana; Owen, Mark; Owen, Rhys Edward; Ozcan, Veysi Erkcan; Ozturk, Nurcan; Pachal, Katherine; Pacheco Pages, Andres; Padilla Aranda, Cristobal; Pagáčová, Martina; Pagan Griso, Simone; Paige, Frank; Pais, Preema; Pajchel, Katarina; Palacino, Gabriel; Palestini, Sandro; Palka, Marek; Pallin, Dominique; Palm, Marcus; Palma, Alberto; Panagiotopoulou, Evgenia; Pandini, Carlo Enrico; Panduro Vazquez, William; Pani, Priscilla; Panitkin, Sergey; Pantea, Dan; Paolozzi, Lorenzo; Papadopoulou, Theodora; Papageorgiou, Konstantinos; Paramonov, Alexander; Paredes Hernandez, Daniela; Parker, Adam Jackson; Parker, Michael Andrew; Parker, Kerry Ann; Parodi, Fabrizio; Parsons, John; Parzefall, Ulrich; Pascuzzi, Vincent; Pasqualucci, Enrico; Passaggio, Stefano; Pastore, Fernanda; Pastore, Francesca; Pásztor, Gabriella; Pataraia, Sophio; Patel, Nikhul; Pater, Joleen; Pauly, Thilo; Pearce, James; Pearson, Benjamin; Pedersen, Lars Egholm; Pedersen, Maiken; Pedraza Lopez, Sebastian; Pedro, Rute; Peleganchuk, Sergey; Pelikan, Daniel; Penc, Ondrej; Peng, Cong; Peng, Haiping; Penwell, John; Peralva, Bernardo; Perego, Marta Maria; Perepelitsa, Dennis; Perez Codina, Estel; Perini, Laura; Pernegger, Heinz; Perrella, Sabrina; Peschke, Richard; Peshekhonov, Vladimir; Peters, Krisztian; Peters, Yvonne; Petersen, Brian; Petersen, Troels; Petit, Elisabeth; Petridis, Andreas; Petridou, Chariclia; Petroff, Pierre; Petrolo, Emilio; Petrov, Mariyan; Petrucci, Fabrizio; Pettersson, Nora Emilia; Peyaud, Alan; Pezoa, Raquel; Phillips, Peter William; Piacquadio, Giacinto; Pianori, Elisabetta; Picazio, Attilio; Piccaro, Elisa; Piccinini, Maurizio; Pickering, Mark Andrew; Piegaia, Ricardo; Pilcher, James; Pilkington, Andrew; Pin, Arnaud Willy J; Pina, João Antonio; Pinamonti, Michele; Pinfold, James; Pingel, Almut; Pires, Sylvestre; Pirumov, Hayk; Pitt, Michael; Plazak, Lukas; Pleier, Marc-Andre; Pleskot, Vojtech; Plotnikova, Elena; Plucinski, Pawel; Pluth, Daniel; Poettgen, Ruth; Poggioli, Luc; Pohl, David-leon; Polesello, Giacomo; Poley, Anne-luise; Policicchio, Antonio; Polifka, Richard; Polini, Alessandro; Pollard, Christopher Samuel; Polychronakos, Venetios; Pommès, Kathy; Pontecorvo, Ludovico; Pope, Bernard; Popeneciu, Gabriel Alexandru; Popovic, Dragan; Poppleton, Alan; Pospisil, Stanislav; Potamianos, Karolos; Potrap, Igor; Potter, Christina; Potter, Christopher; Poulard, Gilbert; Poveda, Joaquin; Pozdnyakov, Valery; Pozo Astigarraga, Mikel Eukeni; Pralavorio, Pascal; Pranko, Aliaksandr; Prell, Soeren; Price, Darren; Price, Lawrence; Primavera, Margherita; Prince, Sebastien; Proissl, Manuel; Prokofiev, Kirill; Prokoshin, Fedor; Protopopescu, Serban; Proudfoot, James; Przybycien, Mariusz; Puddu, Daniele; Puldon, David; Purohit, Milind; Puzo, Patrick; Qian, Jianming; Qin, Gang; Qin, Yang; Quadt, Arnulf; Quayle, William; Queitsch-Maitland, Michaela; Quilty, Donnchadha; Raddum, Silje; Radeka, Veljko; Radescu, Voica; Radhakrishnan, Sooraj Krishnan; Radloff, Peter; Rados, Pere; Ragusa, Francesco; Rahal, Ghita; Raine, John Andrew; Rajagopalan, Srinivasan; Rammensee, Michael; Rangel-Smith, Camila; Ratti, Maria Giulia; Rauscher, Felix; Rave, Stefan; Ravenscroft, Thomas; Raymond, Michel; Read, Alexander Lincoln; Readioff, Nathan Peter; Rebuzzi, Daniela; Redelbach, Andreas; Redlinger, George; Reece, Ryan; Reeves, Kendall; Rehnisch, Laura; Reichert, Joseph; Reisin, Hernan; Rembser, Christoph; Ren, Huan; Rescigno, Marco; Resconi, Silvia; Rezanova, Olga; Reznicek, Pavel; Rezvani, Reyhaneh; Richter, Robert; Richter, Stefan; Richter-Was, Elzbieta; Ricken, Oliver; Ridel, Melissa; Rieck, Patrick; Riegel, Christian Johann; Rieger, Julia; Rifki, Othmane; Rijssenbeek, Michael; Rimoldi, Adele; Rinaldi, Lorenzo; Ristić, Branislav; Ritsch, Elmar; Riu, Imma; Rizatdinova, Flera; Rizvi, Eram; Rizzi, Chiara; Robertson, Steven; Robichaud-Veronneau, Andree; Robinson, Dave; Robinson, James; Robson, Aidan; Roda, Chiara; Rodina, Yulia; Rodriguez Perez, Andrea; Rodriguez Rodriguez, Daniel; Roe, Shaun; Rogan, Christopher Sean; Røhne, Ole; Romaniouk, Anatoli; Romano, Marino; Romano Saez, Silvestre Marino; Romero Adam, Elena; Rompotis, Nikolaos; Ronzani, Manfredi; Roos, Lydia; Ros, Eduardo; Rosati, Stefano; Rosbach, Kilian; Rose, Peyton; Rosenthal, Oliver; Rossetti, Valerio; Rossi, Elvira; Rossi, Leonardo Paolo; Rosten, Jonatan; Rosten, Rachel; Rotaru, Marina; Roth, Itamar; Rothberg, Joseph; Rousseau, David; Royon, Christophe; Rozanov, Alexandre; Rozen, Yoram; Ruan, Xifeng; Rubbo, Francesco; Rubinskiy, Igor; Rud, Viacheslav; Rudolph, Matthew Scott; Rühr, Frederik; Ruiz-Martinez, Aranzazu; Rurikova, Zuzana; Rusakovich, Nikolai; Ruschke, Alexander; Russell, Heather; Rutherfoord, John; Ruthmann, Nils; Ryabov, Yury; Rybar, Martin; Rybkin, Grigori; Ryu, Soo; Ryzhov, Andrey; Saavedra, Aldo; Sabato, Gabriele; Sacerdoti, Sabrina; Sadrozinski, Hartmut; Sadykov, Renat; Safai Tehrani, Francesco; Saha, Puja; Sahinsoy, Merve; Saimpert, Matthias; Saito, Tomoyuki; Sakamoto, Hiroshi; Sakurai, Yuki; Salamanna, Giuseppe; Salamon, Andrea; Salazar Loyola, Javier Esteban; Salek, David; Sales De Bruin, Pedro Henrique; Salihagic, Denis; Salnikov, Andrei; Salt, José; Salvatore, Daniela; Salvatore, Pasquale Fabrizio; Salvucci, Antonio; Salzburger, Andreas; Sammel, Dirk; Sampsonidis, Dimitrios; Sanchez, Arturo; Sánchez, Javier; Sanchez Martinez, Victoria; Sandaker, Heidi; Sandbach, Ruth Laura; Sander, Heinz Georg; Sanders, Michiel; Sandhoff, Marisa; Sandoval, Carlos; Sandstroem, Rikard; Sankey, Dave; Sannino, Mario; Sansoni, Andrea; Santoni, Claudio; Santonico, Rinaldo; Santos, Helena; Santoyo Castillo, Itzebelt; Sapp, Kevin; Sapronov, Andrey; Saraiva, João; Sarrazin, Bjorn; Sasaki, Osamu; Sasaki, Yuichi; Sato, Koji; Sauvage, Gilles; Sauvan, Emmanuel; Savage, Graham; Savard, Pierre; Sawyer, Craig; Sawyer, Lee; Saxon, James; Sbarra, Carla; Sbrizzi, Antonio; Scanlon, Tim; Scannicchio, Diana; Scarcella, Mark; Scarfone, Valerio; 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Simard, Olivier; Simic, Ljiljana; Simion, Stefan; Simioni, Eduard; Simmons, Brinick; Simon, Dorian; Simon, Manuel; Sinervo, Pekka; Sinev, Nikolai; Sioli, Maximiliano; Siragusa, Giovanni; Sivoklokov, Serguei; Sjölin, Jörgen; Sjursen, Therese; Skinner, Malcolm Bruce; Skottowe, Hugh Philip; Skubic, Patrick; Slater, Mark; Slavicek, Tomas; Slawinska, Magdalena; Sliwa, Krzysztof; Slovak, Radim; Smakhtin, Vladimir; Smart, Ben; Smestad, Lillian; Smirnov, Sergei; Smirnov, Yury; Smirnova, Lidia; Smirnova, Oxana; Smith, Matthew; Smith, Russell; Smizanska, Maria; Smolek, Karel; Snesarev, Andrei; Snidero, Giacomo; Snyder, Scott; Sobie, Randall; Socher, Felix; Soffer, Abner; Soh, Dart-yin; Sokhrannyi, Grygorii; Solans Sanchez, Carlos; Solar, Michael; Soldatov, Evgeny; Soldevila, Urmila; Solodkov, Alexander; Soloshenko, Alexei; Solovyanov, Oleg; Solovyev, Victor; Sommer, Philip; Son, Hyungsuk; Song, Hong Ye; Sood, Alexander; Sopczak, Andre; Sopko, Vit; Sorin, Veronica; Sosa, David; Sotiropoulou, Calliope Louisa; Soualah, Rachik; Soukharev, Andrey; South, David; Sowden, Benjamin; Spagnolo, Stefania; Spalla, Margherita; Spangenberg, Martin; Spanò, Francesco; Sperlich, Dennis; Spettel, Fabian; Spighi, Roberto; Spigo, Giancarlo; Spiller, Laurence Anthony; Spousta, Martin; St Denis, Richard Dante; Stabile, Alberto; Stahlman, Jonathan; Stamen, Rainer; Stamm, Soren; Stanecka, Ewa; Stanek, Robert; Stanescu, Cristian; Stanescu-Bellu, Madalina; Stanitzki, Marcel Michael; Stapnes, Steinar; Starchenko, Evgeny; Stark, Giordon; Stark, Jan; Staroba, Pavel; Starovoitov, Pavel; Stärz, Steffen; Staszewski, Rafal; Steinberg, Peter; Stelzer, Bernd; Stelzer, Harald Joerg; Stelzer-Chilton, Oliver; Stenzel, Hasko; Stewart, Graeme; Stillings, Jan Andre; Stockton, Mark; Stoebe, Michael; Stoicea, Gabriel; Stolte, Philipp; Stonjek, Stefan; Stradling, Alden; Straessner, Arno; Stramaglia, Maria Elena; Strandberg, Jonas; Strandberg, Sara; Strandlie, Are; Strauss, Michael; Strizenec, Pavol; Ströhmer, Raimund; Strom, David; Stroynowski, Ryszard; Strubig, Antonia; Stucci, Stefania Antonia; Stugu, Bjarne; Styles, Nicholas Adam; Su, Dong; Su, Jun; Subramaniam, Rajivalochan; Suchek, Stanislav; Sugaya, Yorihito; Suk, Michal; Sulin, Vladimir; Sultansoy, Saleh; Sumida, Toshi; Sun, Siyuan; Sun, Xiaohu; Sundermann, Jan Erik; Suruliz, Kerim; Susinno, Giancarlo; Sutton, Mark; Suzuki, Shota; Svatos, Michal; Swiatlowski, Maximilian; Sykora, Ivan; Sykora, Tomas; Ta, Duc; Taccini, Cecilia; Tackmann, Kerstin; Taenzer, Joe; Taffard, Anyes; Tafirout, Reda; Taiblum, Nimrod; Takai, Helio; Takashima, Ryuichi; Takeda, Hiroshi; Takeshita, Tohru; Takubo, Yosuke; Talby, Mossadek; Talyshev, Alexey; Tam, Jason; Tan, Kong Guan; Tanaka, Junichi; Tanaka, Reisaburo; Tanaka, Shuji; Tannenwald, Benjamin Bordy; Tapia Araya, Sebastian; Tapprogge, Stefan; Tarem, Shlomit; Tartarelli, Giuseppe Francesco; Tas, Petr; Tasevsky, Marek; Tashiro, Takuya; Tassi, Enrico; Tavares Delgado, Ademar; Tayalati, Yahya; Taylor, Aaron; Taylor, Geoffrey; Taylor, Pierre Thor Elliot; Taylor, Wendy; Teischinger, Florian Alfred; Teixeira-Dias, Pedro; Temming, Kim Katrin; Temple, Darren; Ten Kate, Herman; Teng, Ping-Kun; Teoh, Jia Jian; Tepel, Fabian-Phillipp; Terada, Susumu; Terashi, Koji; Terron, Juan; Terzo, Stefano; Testa, Marianna; Teuscher, Richard; Theveneaux-Pelzer, Timothée; Thomas, Juergen; Thomas-Wilsker, Joshuha; Thompson, Emily; Thompson, Paul; Thompson, Ray; Thompson, Stan; Thomsen, Lotte Ansgaard; Thomson, Evelyn; Thomson, Mark; Tibbetts, Mark James; Ticse Torres, Royer Edson; Tikhomirov, Vladimir; Tikhonov, Yury; Timoshenko, Sergey; Tipton, Paul; Tisserant, Sylvain; Todome, Kazuki; Todorov, Theodore; Todorova-Nova, Sharka; Tojo, Junji; Tokár, Stanislav; Tokushuku, Katsuo; Tolley, Emma; Tomlinson, Lee; Tomoto, Makoto; Tompkins, Lauren; Toms, Konstantin; Tong, Baojia(Tony); Torrence, Eric; Torres, Heberth; Torró Pastor, Emma; Toth, Jozsef; Touchard, Francois; Tovey, Daniel; Trefzger, Thomas; Tricoli, Alessandro; Trigger, Isabel Marian; Trincaz-Duvoid, Sophie; Tripiana, Martin; Trischuk, William; Trocmé, Benjamin; Trofymov, Artur; Troncon, Clara; Trottier-McDonald, Michel; Trovatelli, Monica; Truong, Loan; Trzebinski, Maciej; Trzupek, Adam; Tseng, Jeffrey; Tsiareshka, Pavel; Tsipolitis, Georgios; Tsirintanis, Nikolaos; Tsiskaridze, Shota; Tsiskaridze, Vakhtang; Tskhadadze, Edisher; Tsui, Ka Ming; Tsukerman, Ilya; Tsulaia, Vakhtang; Tsuno, Soshi; Tsybychev, Dmitri; Tudorache, Alexandra; Tudorache, Valentina; Tuna, Alexander Naip; Tupputi, Salvatore; Turchikhin, Semen; Turecek, Daniel; Turgeman, Daniel; Turra, Ruggero; Turvey, Andrew John; Tuts, Michael; Tyndel, Mike; Ucchielli, Giulia; Ueda, Ikuo; Ueno, Ryuichi; Ughetto, Michael; Ukegawa, Fumihiko; Unal, Guillaume; Undrus, Alexander; Unel, Gokhan; Ungaro, Francesca; Unno, Yoshinobu; Unverdorben, Christopher; Urban, Jozef; Urquijo, Phillip; Urrejola, Pedro; Usai, Giulio; Usanova, Anna; Vacavant, Laurent; Vacek, Vaclav; Vachon, Brigitte; Valderanis, Chrysostomos; Valdes Santurio, Eduardo; Valencic, Nika; Valentinetti, Sara; Valero, Alberto; Valery, Loic; Valkar, Stefan; Vallecorsa, Sofia; Valls Ferrer, Juan Antonio; Van Den Wollenberg, Wouter; Van Der Deijl, Pieter; van der Geer, Rogier; van der Graaf, Harry; van Eldik, Niels; van Gemmeren, Peter; Van Nieuwkoop, Jacobus; van Vulpen, Ivo; van Woerden, Marius Cornelis; Vanadia, Marco; Vandelli, Wainer; Vanguri, Rami; Vaniachine, Alexandre; Vankov, Peter; Vardanyan, Gagik; Vari, Riccardo; Varnes, Erich; Varol, Tulin; Varouchas, Dimitris; Vartapetian, Armen; Varvell, Kevin; Vasquez, Jared Gregory; Vazeille, Francois; Vazquez Schroeder, Tamara; Veatch, Jason; Veloce, Laurelle Maria; Veloso, Filipe; Veneziano, Stefano; Ventura, Andrea; Venturi, Manuela; Venturi, Nicola; Venturini, Alessio; Vercesi, Valerio; Verducci, Monica; Verkerke, Wouter; Vermeulen, Jos; Vest, Anja; Vetterli, Michel; Viazlo, Oleksandr; Vichou, Irene; Vickey, Trevor; Vickey Boeriu, Oana Elena; Viehhauser, Georg; Viel, Simon; Vigani, Luigi; Vigne, Ralph; Villa, Mauro; Villaplana Perez, Miguel; 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Weber, Michele; Weber, Stefan Wolf; Webster, Jordan S; Weidberg, Anthony; Weinert, Benjamin; Weingarten, Jens; Weiser, Christian; Weits, Hartger; Wells, Phillippa; Wenaus, Torre; Wengler, Thorsten; Wenig, Siegfried; Wermes, Norbert; Werner, Matthias; Werner, Per; Wessels, Martin; Wetter, Jeffrey; Whalen, Kathleen; Whallon, Nikola Lazar; Wharton, Andrew Mark; White, Andrew; White, Martin; White, Ryan; White, Sebastian; Whiteson, Daniel; Wickens, Fred; Wiedenmann, Werner; Wielers, Monika; Wienemann, Peter; Wiglesworth, Craig; Wiik-Fuchs, Liv Antje Mari; Wildauer, Andreas; Wilk, Fabian; Wilkens, Henric George; Williams, Hugh; Williams, Sarah; Willis, Christopher; Willocq, Stephane; Wilson, John; Wingerter-Seez, Isabelle; Winklmeier, Frank; Winston, Oliver James; Winter, Benedict Tobias; Wittgen, Matthias; Wittkowski, Josephine; Wollstadt, Simon Jakob; Wolter, Marcin Wladyslaw; Wolters, Helmut; Wosiek, Barbara; Wotschack, Jorg; Woudstra, Martin; Wozniak, Krzysztof; Wu, Mengqing; Wu, Miles; Wu, Sau Lan; Wu, Xin; Wu, Yusheng; Wyatt, Terry Richard; Wynne, Benjamin; Xella, Stefania; Xu, Da; Xu, Lailin; Yabsley, Bruce; Yacoob, Sahal; Yakabe, Ryota; Yamaguchi, Daiki; Yamaguchi, Yohei; Yamamoto, Akira; Yamamoto, Shimpei; Yamanaka, Takashi; Yamauchi, Katsuya; Yamazaki, Yuji; Yan, Zhen; Yang, Haijun; Yang, Hongtao; Yang, Yi; Yang, Zongchang; Yao, Weiming; Yap, Yee Chinn; Yasu, Yoshiji; Yatsenko, Elena; Yau Wong, Kaven Henry; Ye, Jingbo; Ye, Shuwei; Yeletskikh, Ivan; Yen, Andy L; Yildirim, Eda; Yorita, Kohei; Yoshida, Rikutaro; Yoshihara, Keisuke; Young, Charles; Young, Christopher John; Youssef, Saul; Yu, David Ren-Hwa; Yu, Jaehoon; Yu, Jiaming; Yu, Jie; Yuan, Li; Yuen, Stephanie P; Yusuff, Imran; Zabinski, Bartlomiej; Zaidan, Remi; Zaitsev, Alexander; Zakharchuk, Nataliia; Zalieckas, Justas; Zaman, Aungshuman; Zambito, Stefano; Zanello, Lucia; Zanzi, Daniele; Zeitnitz, Christian; Zeman, Martin; Zemla, Andrzej; Zeng, Jian Cong; Zeng, Qi; Zengel, Keith; Zenin, Oleg; Ženiš, Tibor; Zerwas, Dirk; Zhang, Dongliang; Zhang, Fangzhou; Zhang, Guangyi; Zhang, Huijun; Zhang, Jinlong; Zhang, Lei; Zhang, Rui; Zhang, Ruiqi; Zhang, Xueyao; Zhang, Zhiqing; Zhao, Xiandong; Zhao, Yongke; Zhao, Zhengguo; Zhemchugov, Alexey; Zhong, Jiahang; Zhou, Bing; Zhou, Chen; Zhou, Lei; Zhou, Li; Zhou, Mingliang; Zhou, Ning; Zhu, Cheng Guang; Zhu, Hongbo; Zhu, Junjie; Zhu, Yingchun; Zhuang, Xuai; Zhukov, Konstantin; Zibell, Andre; Zieminska, Daria; Zimine, Nikolai; Zimmermann, Christoph; Zimmermann, Stephanie; Zinonos, Zinonas; Zinser, Markus; Ziolkowski, Michael; Živković, Lidija; Zobernig, Georg; Zoccoli, Antonio; zur Nedden, Martin; Zurzolo, Giovanni; Zwalinski, Lukasz

    2016-05-20

    This paper discusses various observations on beam-induced and cosmic-ray backgrounds in the ATLAS detector during the LHC 2012 proton-proton run. Building on published results based on 2011 data, the correlations between background and residual pressure of the beam vacuum are revisited. Ghost charge evolution over 2012 and its role for backgrounds are evaluated. New methods to monitor ghost charge with beam-gas rates are presented and observations of LHC abort gap population by ghost charge are discussed in detail. Fake jets from colliding bunches and from ghost charge are analysed with improved methods, showing that ghost charge in individual radio-frequency buckets of the LHC can be resolved. Some results of two short periods of dedicated cosmic-ray background data-taking are shown; in particular cosmic-ray muon induced fake jet rates are compared to Monte Carlo simulations and to the fake jet rates from beam background. A thorough analysis of a particular LHC fill, where abnormally high background was obse...

  13. Dose error analysis for a scanned proton beam delivery system

    International Nuclear Information System (INIS)

    Coutrakon, G; Wang, N; Miller, D W; Yang, Y

    2010-01-01

    All particle beam scanning systems are subject to dose delivery errors due to errors in position, energy and intensity of the delivered beam. In addition, finite scan speeds, beam spill non-uniformities, and delays in detector, detector electronics and magnet responses will all contribute errors in delivery. In this paper, we present dose errors for an 8 x 10 x 8 cm 3 target of uniform water equivalent density with 8 cm spread out Bragg peak and a prescribed dose of 2 Gy. Lower doses are also analyzed and presented later in the paper. Beam energy errors and errors due to limitations of scanning system hardware have been included in the analysis. By using Gaussian shaped pencil beams derived from measurements in the research room of the James M Slater Proton Treatment and Research Center at Loma Linda, CA and executing treatment simulations multiple times, statistical dose errors have been calculated in each 2.5 mm cubic voxel in the target. These errors were calculated by delivering multiple treatments to the same volume and calculating the rms variation in delivered dose at each voxel in the target. The variations in dose were the result of random beam delivery errors such as proton energy, spot position and intensity fluctuations. The results show that with reasonable assumptions of random beam delivery errors, the spot scanning technique yielded an rms dose error in each voxel less than 2% or 3% of the 2 Gy prescribed dose. These calculated errors are within acceptable clinical limits for radiation therapy.

  14. Positive correlation between occlusion rate and nidus size of proton beam treated brain arteriovenous malformations (AVMs)

    DEFF Research Database (Denmark)

    Blomquist, Erik; Ronne Engström, Elisabeth; Borota, Ljubisa

    2016-01-01

    symptoms, clinical course, the size of AVM nidus and rate of occlusion was collected. Outcome parameters were the occlusion of the AVM, clinical outcome and side effects.Results. The rate of total occlusion was overall 68%. For target volume 0-2cm3 it was 77%, for 3-10 cm3 80%, for 11-15 cm3 50% and for 16...... of these had no effect and the other only partial occlusion from proton beams. Two thirds of those presenting with seizures reported an improved seizure situation after treatment.Conclusion. Our observations agree with earlier results and show that proton beam irradiation is a treatment alternative for brain......Background. Proton beam radiotherapy of arteriovenous malformations (AVM) in the brain has been performed in Uppsala since 1991. An earlier study based on the first 26 patients concluded that proton beam can be used for treating large and medium sized AVMs that were considered difficult to treat...

  15. SU-E-T-455: Characterization of 3D Printed Materials for Proton Beam Therapy

    International Nuclear Information System (INIS)

    Zou, W; Siderits, R; McKenna, M; Khan, A; Yue, N; McDonough, J; Yin, L; Teo, B; Fisher, T

    2014-01-01

    Purpose: The widespread availability of low cost 3D printing technologies provides an alternative fabrication method for customized proton range modifying accessories such as compensators and boluses. However the material properties of the printed object are dependent on the printing technology used. In order to facilitate the application of 3D printing in proton therapy, this study investigated the stopping power of several printed materials using both proton pencil beam measurements and Monte Carlo simulations. Methods: Five 3–4 cm cubes fabricated using three 3D printing technologies (selective laser sintering, fused-deposition modeling and stereolithography) from five printers were investigated. The cubes were scanned on a CT scanner and the depth dose curves for a mono-energetic pencil beam passing through the material were measured using a large parallel plate ion chamber in a water tank. Each cube was measured from two directions (perpendicular and parallel to printing plane) to evaluate the effects of the anisotropic material layout. The results were compared with GEANT4 Monte Carlo simulation using the manufacturer specified material density and chemical composition data. Results: Compared with water, the differences from the range pull back by the printed blocks varied and corresponded well with the material CT Hounsfield unit. The measurement results were in agreement with Monte Carlo simulation. However, depending on the technology, inhomogeneity existed in the printed cubes evidenced from CT images. The effect of such inhomogeneity on the proton beam is to be investigated. Conclusion: Printed blocks by three different 3D printing technologies were characterized for proton beam with measurements and Monte Carlo simulation. The effects of the printing technologies in proton range and stopping power were studied. The derived results can be applied when specific devices are used in proton radiotherapy

  16. Fabrication of micro-prominences on PTFE surface using proton beam writing

    Energy Technology Data Exchange (ETDEWEB)

    Kitamura, Akane, E-mail: ogawa.akane@jaea.go.jp [Department of Advanced Radiation Technology, Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency, 1233 Watanuki-Machi, Takasaki, Gunma 370-1292 (Japan); Satoh, Takahiro; Koka, Masashi [Department of Advanced Radiation Technology, Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency, 1233 Watanuki-Machi, Takasaki, Gunma 370-1292 (Japan); Kobayashi, Tomohiro [Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 350-0198 (Japan); Kamiya, Tomihiro [Department of Advanced Radiation Technology, Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency, 1233 Watanuki-Machi, Takasaki, Gunma 370-1292 (Japan)

    2013-07-01

    Polytetrafluoroethylene (PTFE) is a typical fluoropolymer and it has several desirable technological properties such as electrical insulation, solid lubrication etc. However, the conventional microstructuring methods have not been well applied to PTFE due to its chemical inertness. Some effective micromachining using synchrotron radiation or ion beam irradiation has been reported. In this study, we create micro-prominences by raising the original surface using proton beam writing (PBW) without chemical etching. A conical prominence was formed by spiral drawing from the center with a 3 MeV proton beam. The body was porous, and the bulk PTFE below the prominence changed to fragmented structures. With decreasing writing speed, the prominence became taller but the height peaked. The prominence gradually reduced in size after the speed reached the optimum value. We expect that these porous projections with high aspect ratio will be versatile in medical fields and microelectromechanical systems (MEMS) technology.

  17. SU-E-J-72: Geant4 Simulations of Spot-Scanned Proton Beam Treatment Plans

    Energy Technology Data Exchange (ETDEWEB)

    Kanehira, T; Sutherland, K; Matsuura, T; Umegaki, K; Shirato, H [Hokkaido University, Sapporo, Hokkaido (Japan)

    2014-06-01

    Purpose: To evaluate density inhomogeneities which can effect dose distributions for real-time image gated spot-scanning proton therapy (RGPT), a dose calculation system, using treatment planning system VQA (Hitachi Ltd., Tokyo) spot position data, was developed based on Geant4. Methods: A Geant4 application was developed to simulate spot-scanned proton beams at Hokkaido University Hospital. A CT scan (0.98 × 0.98 × 1.25 mm) was performed for prostate cancer treatment with three or four inserted gold markers (diameter 1.5 mm, volume 1.77 mm3) in or near the target tumor. The CT data was read into VQA. A spot scanning plan was generated and exported to text files, specifying the beam energy and position of each spot. The text files were converted and read into our Geant4-based software. The spot position was converted into steering magnet field strength (in Tesla) for our beam nozzle. Individual protons were tracked from the vacuum chamber, through the helium chamber, steering magnets, dose monitors, etc., in a straight, horizontal line. The patient CT data was converted into materials with variable density and placed in a parametrized volume at the isocenter. Gold fiducial markers were represented in the CT data by two adjacent voxels (volume 2.38 mm3). 600,000 proton histories were tracked for each target spot. As one beam contained about 1,000 spots, approximately 600 million histories were recorded for each beam on a blade server. Two plans were considered: two beam horizontal opposed (90 and 270 degree) and three beam (0, 90 and 270 degree). Results: We are able to convert spot scanning plans from VQA and simulate them with our Geant4-based code. Our system can be used to evaluate the effect of dose reduction caused by gold markers used for RGPT. Conclusion: Our Geant4 application is able to calculate dose distributions for spot scanned proton therapy.

  18. High-quality electron beam generation in a proton-driven hollow plasma wakefield accelerator

    Science.gov (United States)

    Li, Y.; Xia, G.; Lotov, K. V.; Sosedkin, A. P.; Hanahoe, K.; Mete-Apsimon, O.

    2017-10-01

    Simulations of proton-driven plasma wakefield accelerators have demonstrated substantially higher accelerating gradients compared to conventional accelerators and the viability of accelerating electrons to the energy frontier in a single plasma stage. However, due to the strong intrinsic transverse fields varying both radially and in time, the witness beam quality is still far from suitable for practical application in future colliders. Here we demonstrate the efficient acceleration of electrons in proton-driven wakefields in a hollow plasma channel. In this regime, the witness bunch is positioned in the region with a strong accelerating field, free from plasma electrons and ions. We show that the electron beam carrying the charge of about 10% of 1 TeV proton driver charge can be accelerated to 0.6 TeV with a preserved normalized emittance in a single channel of 700 m. This high-quality and high-charge beam may pave the way for the development of future plasma-based energy frontier colliders.

  19. Characteristic of EBT-XD and EBT3 radiochromic film dosimetry for photon and proton beams

    Science.gov (United States)

    Khachonkham, Suphalak; Dreindl, Ralf; Heilemann, Gerd; Lechner, Wolfgang; Fuchs, Hermann; Palmans, Hugo; Georg, Dietmar; Kuess, Peter

    2018-03-01

    Recently, a new type of radiochromic film, the EBT-XD film, has been introduced for high dose radiotherapy. The EBT-XD film contains the same structure as the EBT3 film but has a slightly different composition and a thinner active layer. This study benchmarks the EBT-XD against EBT3 film for 6 MV and 10 MV photon beams, as well as for 97.4 MeV and 148.2 MeV proton beams and 15-100 kV x-rays. Dosimetric and film reading characteristics, such as post irradiation darkening, film orientation effect, lateral response artifact (LRA), film sensitivity, energy and beam quality dependency were investigated. Furthermore, quenching effects in the Bragg peak were investigated for a single proton beam energy for both film types, in addition measurements were performed in a spread-out Bragg peak. EBT-XD films showed the same characteristic on film darkening as EBT3. The effects between portrait and landscape orientation were reduced by 3.1% (in pixel value) for EBT-XD compared to EBT3 at a dose of 2000 cGy. The LRA is reduced for EBT-XD films for all investigated dose ranges. The sensitivity of EBT-XD films is superior to EBT3 for doses higher than 500 cGy. In addition, EBT-XD showed a similar dosimetric response for photon and proton irradiation with low energy and beam quality dependency. A quenching effect of 10% was found for both film types. The slight decrease in the thickness of the active layer and different composition configuration of EBT-XD resulted in a reduced film orientation effect and LRA, as well as a sensitivity increase in high-dose regions for both photon and proton beams. Overall, the EBT-XD film improved regarding film reading characteristics and showed advantages in the high-dose region for photon and proton beams.

  20. Characteristic of EBT-XD and EBT3 radiochromic film dosimetry for photon and proton beams.

    Science.gov (United States)

    Khachonkham, Suphalak; Dreindl, Ralf; Heilemann, Gerd; Lechner, Wolfgang; Fuchs, Hermann; Palmans, Hugo; Georg, Dietmar; Kuess, Peter

    2018-03-15

    Recently, a new type of radiochromic film, the EBT-XD film, has been introduced for high dose radiotherapy. The EBT-XD film contains the same structure as the EBT3 film but has a slightly different composition and a thinner active layer. This study benchmarks the EBT-XD against EBT3 film for 6 MV and 10 MV photon beams, as well as for 97.4 MeV and 148.2 MeV proton beams and 15-100 kV x-rays. Dosimetric and film reading characteristics, such as post irradiation darkening, film orientation effect, lateral response artifact (LRA), film sensitivity, energy and beam quality dependency were investigated. Furthermore, quenching effects in the Bragg peak were investigated for a single proton beam energy for both film types, in addition measurements were performed in a spread-out Bragg peak. EBT-XD films showed the same characteristic on film darkening as EBT3. The effects between portrait and landscape orientation were reduced by 3.1% (in pixel value) for EBT-XD compared to EBT3 at a dose of 2000 cGy. The LRA is reduced for EBT-XD films for all investigated dose ranges. The sensitivity of EBT-XD films is superior to EBT3 for doses higher than 500 cGy. In addition, EBT-XD showed a similar dosimetric response for photon and proton irradiation with low energy and beam quality dependency. A quenching effect of 10% was found for both film types. The slight decrease in the thickness of the active layer and different composition configuration of EBT-XD resulted in a reduced film orientation effect and LRA, as well as a sensitivity increase in high-dose regions for both photon and proton beams. Overall, the EBT-XD film improved regarding film reading characteristics and showed advantages in the high-dose region for photon and proton beams.

  1. Development of hollow electron beams for proton and ion collimation

    CERN Document Server

    Stancari, G; Kuznetsov, G; Shiltsev, V; Still, D A; Valishev, A; Vorobiev, L G; Assmann, R; Kabantsev, A

    2012-01-01

    Magnetically confined hollow electron beams for controlled halo removal in high-energy colliders such as the Tevatron or the LHC may extend traditional collimation systems beyond the intensity limits imposed by tolerable material damage. They may also improve collimation performance by suppressing loss spikes due to beam jitter and by increasing capture efficiency. A hollow electron gun was designed and built. Its performance and stability were measured at the Fermilab test stand. The gun will be installed in one of the existing Tevatron electron lenses for preliminary tests of the hollow-beam collimator concept, addressing critical issues such as alignment and instabilities of the overlapping proton and electron beams.

  2. Development of hollow electron beams for proton and ion collimation

    CERN Document Server

    Stancari, G.; Kuznetsov, G.; Shiltsev, V.; Still, D.A.; Valishev, A.; Vorobiev, L.G.; Assmann, R.; Kabantsev, A.

    2010-01-01

    Magnetically confined hollow electron beams for controlled halo removal in high-energy colliders such as the Tevatron or the LHC may extend traditional collimation systems beyond the intensity limits imposed by tolerable material damage. They may also improve collimation performance by suppressing loss spikes due to beam jitter and by increasing capture efficiency. A hollow electron gun was designed and built. Its performance and stability were measured at the Fermilab test stand. The gun will be installed in one of the existing Tevatron electron lenses for preliminary tests of the hollow-beam collimator concept, addressing critical issues such as alignment and instabilities of the overlapping proton and electron beams

  3. PIXE analysis using external proton beam

    Energy Technology Data Exchange (ETDEWEB)

    Potocek, V; Potockova, J; Dzmuran, R; Sikora, J

    1985-03-01

    The possibilities were studied of the practical use of the analytical PIXE method. Calibration samples were analyzed of Cu, Cd, Hg and Pb in concentrations of 50 to 500 ..mu..g/l as well as natural samples of drinking water, pond water, human blood plasma, dry waste from ground vegetation, mushrooms, pine needles, aerosols, human hair, leaves and flowers, etc. The samples were processed using precipitation, mineralization or incineration and were trapped on a membrane filter (Synpor) or on a Tatrafan ON 15 foil. Some samples were freeze-dried and compressed into pellets. A proton beam with an intensity of 10 to 70 nA was used for analysis and the proton energy was selected 2.2 MeV. For most targets an exposure of 120 s was preset and the measurement lasted at least 60 s and 600 s at the most. It was found that Synpor filters browned and became more brittle during longer exposures. The other targets did not change during analysis.

  4. Development of a semi-analytical method for calculation of the radial dose profile for proton beams in the 0.5-1.0 MeV energy range

    International Nuclear Information System (INIS)

    Wiklund, Kristin

    2004-07-01

    There has been an increased interest in the application of protons for radiation therapy during the last decades. The main reason for this is the advantageous shape of the proton dose profile, which offers the possibility of improved treatment outcome. Proton beams and other light ions have because of this observed phenomenon a high efficiency to inflict lethal damage to tumor tissue while sparing normal tissue. Treatment with ions heavier than protons, have also been considered on the basis of radiological arguments. Recently scientists have discovered that not only high-energy electrons inflict severe damage to the DNA, but also low-energy electrons. Those electrons can be produced when protons with energy between 0.5-1 MeV interact with matter. High-accuracy calculations of dose distributions inside tumors and the surrounding tissue are essential for assessing the effectiveness of a given treatment in terms of probability of tumor control and of radiation-induced complications. The use of Monte Carlo methods to simulate radiation transport has become the most accurate means of predicting absorbed dose distributions and other quantities like numbers of track ends, track lengths and angular distributions. Today, there no accurate Monte-Carlo codes for proton transport, not even for low-energy electron transport. Much work is devoted to develop a Monte Carlo code for this purpose. However, for most practical cases in treatment planning, an advantageous solution has been found by combining the intrinsic accuracy of Monte Carlo methods with the swiftness of analytical techniques. In this work, a simple semi-analytical method is developed for fast dose distribution calculations for protons with energy range 0.5-1 MeV. The major part of the energy loss when protons traverse tissue, ends up in the ionizations of the target atoms. The double differential cross sections for this secondary electron production is calculated with Continuous distorted waves-eikonal initial

  5. Numerical investigation on complex target geometries in the context of laser-accelerated proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Deppert, O.; Harres, K.; Busold, S.; Schaumann, G.; Roth, M. [IKP, Technische Universitaet Darmstadt (Germany); Brabetz, C. [IAP, Goethe Universitaet Frankfurt (Germany); Schollmeier, M.; Geissel, M. [Sandia National Laboratories, NM (United States); Bagnoud, V. [GSI - Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Neely, D. [Rutherford Appleton Laboratory (United Kingdom); McKenna, P. [University of Strathclyde (United Kingdom)

    2012-07-01

    The irradiation of thin metal foils by an ultra-intense laser pulse leads to the generation of a highly laminar, intense proton beam accelerated from the target rear side by a mechanism called TNSA. This acceleration mechanism strongly depends on the geometry of the target. The acceleration originates from the formation of a Gaussian-like electron sheath leading to an electric field in the order of TV/m. This sheath field-ionizes the target rear side and is able to accelerate protons from a hydrogen contamination layer. The Gaussian-like sheath adds an energy dependent divergence to the spatial proton beam profile. For future applications it is essential to reduce the divergence already from the source of the acceleration process. Therefore different target geometries were studied numerically with the help of Particle-In-Cell (PIC) simulations. Both, the influence of the target geometry as well as the influence of the laser beam profile onto the proton trajectories are discussed. Furthermore, the first experimental results of a dedicated target geometry for laser-ion acceleration are presented.

  6. GPU-based fast pencil beam algorithm for proton therapy

    International Nuclear Information System (INIS)

    Fujimoto, Rintaro; Nagamine, Yoshihiko; Kurihara, Tsuneya

    2011-01-01

    Performance of a treatment planning system is an essential factor in making sophisticated plans. The dose calculation is a major time-consuming process in planning operations. The standard algorithm for proton dose calculations is the pencil beam algorithm which produces relatively accurate results, but is time consuming. In order to shorten the computational time, we have developed a GPU (graphics processing unit)-based pencil beam algorithm. We have implemented this algorithm and calculated dose distributions in the case of a water phantom. The results were compared to those obtained by a traditional method with respect to the computational time and discrepancy between the two methods. The new algorithm shows 5-20 times faster performance using the NVIDIA GeForce GTX 480 card in comparison with the Intel Core-i7 920 processor. The maximum discrepancy of the dose distribution is within 0.2%. Our results show that GPUs are effective for proton dose calculations.

  7. On some methods to produce high-energy polarized electron beams by means of proton synchrotrons

    International Nuclear Information System (INIS)

    Bessonov, E.G.; Vazdik, Ya.A.

    1980-01-01

    Some methods of production of high-energy polarized electron beams by means of proton synchrotrons are considered. These methods are based on transfer by protons of a part of their energy to the polarized electrons of a thin target placed inside the working volume of the synchrotron. It is suggested to use as a polarized electron target a magnetized crystalline iron in which proton channeling is realized, polarized atomic beams and the polarized plasma. It is shown that by this method one can produce polarized electron beams with energy approximately 100 GeV, energy spread +- 5 % and intensity approximately 10 7 electron/c, polarization approximately 30% and with intensity approximately 10 4 -10 5 electron/c, polarization approximately 100% [ru

  8. Effects of High-Energy Proton-Beam Irradiation on the Magnetic Properties of ZnO Nanorods

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jun Kue; Kwon, Hyeok-Jung; Cho, Yong Sub [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    There are still many problem for the application due to its unstable magnetism state and too small magnetization values. Here we investigate magnetic properties of ZnO nanorods after high-energy proton-beam irradiation. Electron spin resonance (ESR) measurement on temperature was made to identify intrinsic or extrinsic defects as well as to observe magnetic ordering after irradiation. Understanding the effects of proton beam irradiation on magnetic behavior may help to shed light on the mechanism responsible for the magnetic ordering in this material. We have investigated proton-beam irradiation effects on the magnetic properties of ZnO nanorods. After irradiation a broad ESR line is observed, indicating emergence of ferromagnetic ordering up to room temperature. In M-H curve, stronger coercive field is observed after irradiation.

  9. Development of the heat sink structure of a beam dump for the proton accelerator

    International Nuclear Information System (INIS)

    Maeng, W. Y.; Gil, C. S.; Kim, J. H.; Kim, D. H.

    2007-01-01

    The beam dump is the essential component for the good beam quality and the reliable performance of the proton accelerator. The beam dump for a 20 MeV and 20 mA proton accelerator was designed and manufactured in this study. The high heats deposited, and the large amount of radioactivity produced in beam dump should be reduced by the proper heat sink structure. The heat source by the proton beam of 20 MeV and 20 mA was calculated. The radioactivity assessments of the beam dump were carried out for the economic shielding design with safety. The radioactivity by the protons and secondary neutrons in designed beam dump were calculated in this sturdy. The effective engineering design for the beam dump cooling was performed, considering the mitigation methods of the deposited heats with small angle, the power densities with the stopping ranges in the materials and the heat distributions in the beam dump. The heat sink structure of the beam dump was designed to meet the accelerator characteristics by placing two plates of 30 cm by 60 cm at an angle of 12 degree. The highest temperatures of the graphite, copper, and copper faced by cooling water were designed to be 223 degree, 146 degree, and 85 degree, respectively when the velocity of cooling water was 3 m/s. The heat sink structure was manufactured by the brazing graphite tiles to a copper plate with the filler alloy of Ti-Cu-Ag. The brazing procedure was developed. The tensile stress of the graphite was less than 75% of a maximum tensile stress during the accelerator operation based on the analysis. The safety analyses for the commissioning of the accelerator operation were also performed. The specimens from the brazed parts of beam dump structure were made to identify manufacturing problems. The soundness of the heat sink structure of the beam dump was confirmed by the fatigue tests of the brazed specimens of the graphite-copper tile components with the repetitive heating and cooling. The heat sink structure developed

  10. Prototype system for proton beam range measurement based on gamma electron vertex imaging

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Han Rim [Neutron Utilization Technology Division, Korea Atomic Energy Research Institute, 111, Daedeok-daero 989beon-gil, Yuseong-gu, Daejeon 34057 (Korea, Republic of); Kim, Sung Hun; Park, Jong Hoon [Department of Nuclear Engineering, Hanyang University, Seongdong-gu, Seoul 04763 (Korea, Republic of); Jung, Won Gyun [Heavy-ion Clinical Research Division, Korean Institute of Radiological & Medical Sciences, Seoul 01812 (Korea, Republic of); Lim, Hansang [Department of Electronics Convergence Engineering, Kwangwoon University, Seoul 01897 (Korea, Republic of); Kim, Chan Hyeong, E-mail: chkim@hanyang.ac.kr [Department of Nuclear Engineering, Hanyang University, Seongdong-gu, Seoul 04763 (Korea, Republic of)

    2017-06-11

    In proton therapy, for both therapeutic effectiveness and patient safety, it is very important to accurately measure the proton dose distribution, especially the range of the proton beam. For this purpose, recently we proposed a new imaging method named gamma electron vertex imaging (GEVI), in which the prompt gammas emitting from the nuclear reactions of the proton beam in the patient are converted to electrons, and then the converted electrons are tracked to determine the vertices of the prompt gammas, thereby producing a 2D image of the vertices. In the present study, we developed a prototype GEVI system, including dedicated signal processing and data acquisition systems, which consists of a beryllium plate (= electron converter) to convert the prompt gammas to electrons, two double-sided silicon strip detectors (= hodoscopes) to determine the trajectories of those converted electrons, and a plastic scintillation detector (= calorimeter) to measure their kinetic energies. The system uses triple coincidence logic and multiple energy windows to select only the events from prompt gammas. The detectors of the prototype GEVI system were evaluated for electronic noise level, energy resolution, and time resolution. Finally, the imaging capability of the GEVI system was tested by imaging a {sup 90}Sr beta source, a {sup 60}Co gamma source, and a 45-MeV proton beam in a PMMA phantom. The overall results of the present study generally show that the prototype GEVI system can image the vertices of the prompt gammas produced by the proton nuclear interactions.

  11. WE-E-BRB-00: Motion Management for Pencil Beam Scanning Proton Therapy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-06-15

    Strategies for treating thoracic and liver tumors using pencil beam scanning proton therapy Thoracic and liver tumors have not been treated with pencil beam scanning (PBS) proton therapy until recently. This is because of concerns about the significant interplay effects between proton spot scanning and patient’s respiratory motion. However, not all tumors have unacceptable magnitude of motion for PBS proton therapy. Therefore it is important to analyze the motion and understand the significance of the interplay effect for each patient. The factors that affect interplay effect and its washout include magnitude of motion, spot size, spot scanning sequence and speed. Selection of beam angle, scanning direction, repainting and fractionation can all reduce the interplay effect. An overview of respiratory motion management in PBS proton therapy including assessment of tumor motion and WET evaluation will be first presented. As thoracic tumors have very different motion patterns from liver tumors, examples would be provided for both anatomic sites. As thoracic tumors are typically located within highly heterogeneous environments, dose calculation accuracy is a concern for both treatment target and surrounding organs such as spinal cord or esophagus. Strategies for mitigating the interplay effect in PBS will be presented and the pros and cons of various motion mitigation strategies will be discussed. Learning Objectives: Motion analysis for individual patients with respect to interplay effect Interplay effect and mitigation strategies for treating thoracic/liver tumors with PBS Treatment planning margins for PBS The impact of proton dose calculation engines over heterogeneous treatment target and surrounding organs I have a current research funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian; L. Lin, I have a current funding from Varian Medical System under the master agreement between University of Pennsylvania and

  12. WE-E-BRB-00: Motion Management for Pencil Beam Scanning Proton Therapy

    International Nuclear Information System (INIS)

    2016-01-01

    Strategies for treating thoracic and liver tumors using pencil beam scanning proton therapy Thoracic and liver tumors have not been treated with pencil beam scanning (PBS) proton therapy until recently. This is because of concerns about the significant interplay effects between proton spot scanning and patient’s respiratory motion. However, not all tumors have unacceptable magnitude of motion for PBS proton therapy. Therefore it is important to analyze the motion and understand the significance of the interplay effect for each patient. The factors that affect interplay effect and its washout include magnitude of motion, spot size, spot scanning sequence and speed. Selection of beam angle, scanning direction, repainting and fractionation can all reduce the interplay effect. An overview of respiratory motion management in PBS proton therapy including assessment of tumor motion and WET evaluation will be first presented. As thoracic tumors have very different motion patterns from liver tumors, examples would be provided for both anatomic sites. As thoracic tumors are typically located within highly heterogeneous environments, dose calculation accuracy is a concern for both treatment target and surrounding organs such as spinal cord or esophagus. Strategies for mitigating the interplay effect in PBS will be presented and the pros and cons of various motion mitigation strategies will be discussed. Learning Objectives: Motion analysis for individual patients with respect to interplay effect Interplay effect and mitigation strategies for treating thoracic/liver tumors with PBS Treatment planning margins for PBS The impact of proton dose calculation engines over heterogeneous treatment target and surrounding organs I have a current research funding from Varian Medical System under the master agreement between University of Pennsylvania and Varian; L. Lin, I have a current funding from Varian Medical System under the master agreement between University of Pennsylvania and

  13. Coherent instabilities of proton beams in accelerators and storage rings - experimental results, diagnosis and cures

    International Nuclear Information System (INIS)

    Schnell, W.

    1977-01-01

    The author discusses diagnosis and cure of proton beam instabilities in accelerators and storage rings. Coasting beams and bunched beams are treated separately and both transverse and longitudinal instabilities are considered. (B.D.)

  14. Large Logarithms in the Beam Normal Spin Asymmetry of Elastic Electron--Proton Scattering

    Energy Technology Data Exchange (ETDEWEB)

    Andrei Afanasev; Mykola Merenkov

    2004-06-01

    We study a parity-conserving single-spin beam asymmetry of elastic electron-proton scattering induced by an absorptive part of the two-photon exchange amplitude. It is demonstrated that excitation of inelastic hadronic intermediate states by the consecutive exchange of two photons leads to logarithmic and double-logarithmic enhancement due to contributions of hard collinear quasi-real photons. The asymmetry at small electron scattering angles is expressed in terms of the total photoproduction cross section on the proton, and is predicted to reach the magnitude of 20-30 parts per million. At these conditions and fixed 4-momentum transfers, the asymmetry is rising logarithmically with increasing electron beam energy, following the high-energy diffractive behavior of total photoproduction cross section on the proton.

  15. Transport and energy selection of laser generated protons for postacceleration with a compact linac

    Science.gov (United States)

    Sinigardi, Stefano; Turchetti, Giorgio; Londrillo, Pasquale; Rossi, Francesco; Giove, Dario; De Martinis, Carlo; Sumini, Marco

    2013-03-01

    Laser accelerated proton beams have a considerable potential for various applications including oncological therapy. However, the most consolidated target normal sheath acceleration regime based on irradiation of solid targets provides an exponential energy spectrum with a significant divergence. The low count number at the cutoff energy seriously limits at present its possible use. One realistic scenario for the near future is offered by hybrid schemes. The use of transport lines for collimation and energy selection has been considered. We present here a scheme based on a high field pulsed solenoid and collimators which allows one to select a beam suitable for injection at 30 MeV into a compact linac in order to double its energy while preserving a significant intensity. The results are based on a fully 3D simulation starting from laser acceleration.

  16. Cost-effectiveness analysis of cochlear dose reduction by proton beam therapy for medulloblastoma in childhood

    International Nuclear Information System (INIS)

    Hirano, Emi; Kawabuchi, Koichi; Fuji, Hiroshi; Onoe, Tsuyoshi; Kumar, Vinay; Shirato, Hiroki

    2014-01-01

    The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after treatment with proton or X-ray radiotherapy. The risks of hearing loss were calculated on cochlear dose for each treatment. Three types of health-related quality of life (HRQOL) of EQ-5D, HUI3 and SF-6D were used for estimation of quality-adjusted life years (QALYs). The incremental cost-effectiveness ratio (ICER) for proton beam therapy compared with X-ray radiotherapy was calculated for each HRQOL. Sensitivity analyses were performed to model uncertainty in these parameters. The ICER for EQ-5D, HUI3 and SF-6D were $21 716/QALY, $11 773/QALY, and $20 150/QALY, respectively. One-way sensitivity analyses found that the results were sensitive to discount rate, the risk of hearing loss after proton therapy, and costs of proton irradiation. Cost-effectiveness acceptability curve analysis revealed a 99% probability of proton therapy being cost effective at a societal willingness-to-pay value. Proton beam therapy with cochlear dose reduction improves health outcomes at a cost that is within the acceptable cost-effectiveness range from the payer's standpoint. (author)

  17. Third-order TRANSPORT: A computer program for designing charged particle beam transport systems

    International Nuclear Information System (INIS)

    Carey, D.C.; Brown, K.L.; Rothacker, F.

    1995-05-01

    TRANSPORT has been in existence in various evolutionary versions since 1963. The present version of TRANSPORT is a first-, second-, and third-order matrix multiplication computer program intended for the design of static-magnetic beam transport systems. This report discusses the following topics on TRANSPORT: Mathematical formulation of TRANSPORT; input format for TRANSPORT; summaries of TRANSPORT elements; preliminary specifications; description of the beam; physical elements; other transformations; assembling beam lines; operations; variation of parameters for fitting; and available constraints -- the FIT command

  18. Self-pinched lithium beam transport experiments on SABRE

    International Nuclear Information System (INIS)

    Hanson, D.L.; Olson, C.L.; Poukey, J.W.; Shokir, I.; Cuneo, M.E.; Menge, P.R.; Johnston, R.R.; Welch, D.R.

    1996-01-01

    Self-pinched transport of ion beams has many advantages for ion-driven ICF applications involving high yield and energy production. The authors are currently preparing for a self-pinched lithium beam transport experiment on the SABRE accelerator. There are three transport elements that must eventually be demonstrated: (1) efficient lithium beam generation and ballistic transport to a focus at the self-pinched transport channel entrance; (2) self-pinched transport in the channel, requiring optimized injection conditions and gas breakdown; and (3) self-pinched transport of the equilibrated beam from the channel into free space, with associated aiming and stability considerations. In the present experiment, a hollow annular lithium beam from an applied-B extraction ion diode will be focused to small radius (r ≤ 2 cm) in a 60 cm long ballistic focus section containing argon gas at a pressure of a few Torr. The self-pinched transport channel will contain a low pressure background gas of 10--40 mTorr argon to allow sufficient net current to confine the beam for long distance transport. IPROP simulations are in progress to optimize the design of the ballistic and self-pinched transport sections. Progress on preparation of this lithium self-pinched transport experiment, including a discussion of transport system design, important gas breakdown issues, and diagnostics, will be presented

  19. Adjuvant Ab Interno Tumor Treatment After Proton Beam Irradiation.

    Science.gov (United States)

    Seibel, Ira; Riechardt, Aline I; Heufelder, Jens; Cordini, Dino; Joussen, Antonia M

    2017-06-01

    This study was performed to show long-term outcomes concerning globe preservation in uveal melanoma patients after proton beam therapy with the main focus on outcomes according to different adjuvant ab interno surgical procedures. Retrospective cohort study. All patients treated with primary proton beam therapy for choroidal or ciliary body melanoma between June 1998 and June 2015 were included. A total of 2499 patients underwent primary proton beam therapy, with local tumor control and globe preservation rates of 95.9% and 94.8% after 5 years, respectively. A total of 110 (4.4%) patients required secondary enucleation. Unresponsive neovascular glaucoma was the leading cause of secondary enucleation in 78 of the 2499 patients (3.1%). The 5-year enucleation-free survival rate was 94.8% in the endoresection group, 94.3% in the endodrainage group, and 93.5% in the comparator group. The log-rank test showed P = .014 (comparator group vs endoresection group) and P = .06 (comparator group vs endodrainage-vitrectomy group). Patients treated with endoresection or endodrainage-vitrectomy developed less radiation retinopathy (30.5% and 37.4% after 5 years, P = .001 and P = .048 [Kaplan-Meier], respectively) and less neovascular glaucoma (11.6% and 21.3% after 5 years, P = .001 and P = .01 [Kaplan-Meier], respectively) compared with the comparator group (52.3% radiation retinopathy and 57.8% neovascular glaucoma after 5 years). This study suggests that in larger tumors the enucleation and neovascular glaucoma rates might be reduced by adjuvant surgical procedures. Although endoresection is the most promising adjuvant treatment option, the endodrainage-vitrectomy is recommended in patients who are ineligible for endoresection. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Variations in the Processing of DNA Double-Strand Breaks Along 60-MeV Therapeutic Proton Beams

    Energy Technology Data Exchange (ETDEWEB)

    Chaudhary, Pankaj; Marshall, Thomas I. [Centre for Cancer Research and Cell Biology, Queen' s University Belfast, Belfast (United Kingdom); Currell, Frederick J. [Centre for Cancer Research and Cell Biology, Queen' s University Belfast, Belfast (United Kingdom); Centre for Plasma Physics, School of Mathematics and Physics, Queen' s University Belfast, Belfast (United Kingdom); Kacperek, Andrzej [Douglas Cyclotron, Clatterbridge Cancer Centre, Bebbington, Wirral (United Kingdom); Schettino, Giuseppe, E-mail: giuseppe.schettino@npl.co.uk [National Physical Laboratory, Teddington (United Kingdom); Prise, Kevin M. [Centre for Cancer Research and Cell Biology, Queen' s University Belfast, Belfast (United Kingdom)

    2016-05-01

    Purpose: To investigate the variations in induction and repair of DNA damage along the proton path, after a previous report on the increasing biological effectiveness along clinically modulated 60-MeV proton beams. Methods and Materials: Human skin fibroblast (AG01522) cells were irradiated along a monoenergetic and a modulated spread-out Bragg peak (SOBP) proton beam used for treating ocular melanoma at the Douglas Cyclotron, Clatterbridge Centre for Oncology, Wirral, Liverpool, United Kingdom. The DNA damage response was studied using the 53BP1 foci formation assay. The linear energy transfer (LET) dependence was studied by irradiating the cells at depths corresponding to entrance, proximal, middle, and distal positions of SOBP and the entrance and peak position for the pristine beam. Results: A significant amount of persistent foci was observed at the distal end of the SOBP, suggesting complex residual DNA double-strand break damage induction corresponding to the highest LET values achievable by modulated proton beams. Unlike the directly irradiated, medium-sharing bystander cells did not show any significant increase in residual foci. Conclusions: The DNA damage response along the proton beam path was similar to the response of X rays, confirming the low-LET quality of the proton exposure. However, at the distal end of SOBP our data indicate an increased complexity of DNA lesions and slower repair kinetics. A lack of significant induction of 53BP1 foci in the bystander cells suggests a minor role of cell signaling for DNA damage under these conditions.

  1. Beam dynamics study in the C235 cyclotron for proton therapy

    International Nuclear Information System (INIS)

    Karamysheva, G.A.; Kostromin, S.A.

    2008-01-01

    Study of the beam dynamics in the C235 cyclotron dedicated to the proton therapy is presented. Results of the computer simulations of the particle motion in the measured magnetic field are given. Study of the resonance influence on the acceleration process was carried out. The corresponding tolerances on the magnetic field imperfections and transverse beam parameters were defined using these simulations

  2. Optimization of GATE and PHITS Monte Carlo code parameters for spot scanning proton beam based on simulation with FLUKA general-purpose code

    Energy Technology Data Exchange (ETDEWEB)

    Kurosu, Keita [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202 (United States); Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871 (Japan); Department of Radiology, Osaka University Hospital, Suita, Osaka 565-0871 (Japan); Das, Indra J. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202 (United States); Moskvin, Vadim P. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202 (United States); Department of Radiation Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105 (United States)

    2016-01-15

    Spot scanning, owing to its superior dose-shaping capability, provides unsurpassed dose conformity, in particular for complex targets. However, the robustness of the delivered dose distribution and prescription has to be verified. Monte Carlo (MC) simulation has the potential to generate significant advantages for high-precise particle therapy, especially for medium containing inhomogeneities. However, the inherent choice of computational parameters in MC simulation codes of GATE, PHITS and FLUKA that is observed for uniform scanning proton beam needs to be evaluated. This means that the relationship between the effect of input parameters and the calculation results should be carefully scrutinized. The objective of this study was, therefore, to determine the optimal parameters for the spot scanning proton beam for both GATE and PHITS codes by using data from FLUKA simulation as a reference. The proton beam scanning system of the Indiana University Health Proton Therapy Center was modeled in FLUKA, and the geometry was subsequently and identically transferred to GATE and PHITS. Although the beam transport is managed by spot scanning system, the spot location is always set at the center of a water phantom of 600 × 600 × 300 mm{sup 3}, which is placed after the treatment nozzle. The percentage depth dose (PDD) is computed along the central axis using 0.5 × 0.5 × 0.5 mm{sup 3} voxels in the water phantom. The PDDs and the proton ranges obtained with several computational parameters are then compared to those of FLUKA, and optimal parameters are determined from the accuracy of the proton range, suppressed dose deviation, and computational time minimization. Our results indicate that the optimized parameters are different from those for uniform scanning, suggesting that the gold standard for setting computational parameters for any proton therapy application cannot be determined consistently since the impact of setting parameters depends on the proton irradiation

  3. Optimization of GATE and PHITS Monte Carlo code parameters for spot scanning proton beam based on simulation with FLUKA general-purpose code

    International Nuclear Information System (INIS)

    Kurosu, Keita; Das, Indra J.; Moskvin, Vadim P.

    2016-01-01

    Spot scanning, owing to its superior dose-shaping capability, provides unsurpassed dose conformity, in particular for complex targets. However, the robustness of the delivered dose distribution and prescription has to be verified. Monte Carlo (MC) simulation has the potential to generate significant advantages for high-precise particle therapy, especially for medium containing inhomogeneities. However, the inherent choice of computational parameters in MC simulation codes of GATE, PHITS and FLUKA that is observed for uniform scanning proton beam needs to be evaluated. This means that the relationship between the effect of input parameters and the calculation results should be carefully scrutinized. The objective of this study was, therefore, to determine the optimal parameters for the spot scanning proton beam for both GATE and PHITS codes by using data from FLUKA simulation as a reference. The proton beam scanning system of the Indiana University Health Proton Therapy Center was modeled in FLUKA, and the geometry was subsequently and identically transferred to GATE and PHITS. Although the beam transport is managed by spot scanning system, the spot location is always set at the center of a water phantom of 600 × 600 × 300 mm 3 , which is placed after the treatment nozzle. The percentage depth dose (PDD) is computed along the central axis using 0.5 × 0.5 × 0.5 mm 3 voxels in the water phantom. The PDDs and the proton ranges obtained with several computational parameters are then compared to those of FLUKA, and optimal parameters are determined from the accuracy of the proton range, suppressed dose deviation, and computational time minimization. Our results indicate that the optimized parameters are different from those for uniform scanning, suggesting that the gold standard for setting computational parameters for any proton therapy application cannot be determined consistently since the impact of setting parameters depends on the proton irradiation technique

  4. New technique for levitating solid particles using a proton beam

    International Nuclear Information System (INIS)

    Misconi, N.Y.

    1996-01-01

    A new technique for levitating solid particles inside a vacuum chamber is developed using a proton beam. This new technique differs from the classical laser-levitation technique invented by Ashkin in that it does not heat up light-absorbing levitated particles to vaporization. This unique property of the method will make it possible to levitate real interplanetary dust particles in a vacuum chamber and study their spin-up dynamics in a ground-based laboratory. It is found that a flux of protons from a proton gun of ∼ 10 15 cm -2 sec -1 is needed to levitate a 10-mm particle. Confinement of the levitated particle can be achieved by a Z or θ pinch to create a gravity well, or by making the beam profile doughnut in shape. In levitating real interplanetary particles, two spin-up mechanisms can be investigated using this technique: one is the Paddack Effect and the other is a spin-up mechanism by the interaction of F-coronal dust with CMEs (Coronal Mass Ejections). The real interplanetary particles were collected by Brownie and associates (also known as the Brownie Particles) from the earth's upper atmosphere. (author)

  5. High-energy monoenergetic proton beams from two stage acceleration with a slow laser pulse

    Directory of Open Access Journals (Sweden)

    H. Y. Wang

    2015-02-01

    Full Text Available We present a new regime to generate high-energy quasimonoenergetic proton beams in a “slow-pulse” regime, where the laser group velocity v_{g}proton beams can be generated. It is shown by multidimensional particle-in-cell simulation that quasimonoenergetic proton beams with energy up to hundreds of MeV can be generated at laser intensities of 10^{21}  W/cm^{2}.

  6. Beam Extraction and Transport

    CERN Document Server

    Kalvas, T.

    2013-12-16

    This chapter gives an introduction to low-energy beam transport systems, and discusses the typically used magnetostatic elements (solenoid, dipoles and quadrupoles) and electrostatic elements (einzel lens, dipoles and quadrupoles). The ion beam emittance, beam space-charge effects and the physics of ion source extraction are introduced. Typical computer codes for analysing and designing ion optical systems are mentioned, and the trajectory tracking method most often used for extraction simulations is described in more detail.

  7. Proton beam writing for producing holographic images

    International Nuclear Information System (INIS)

    Ow, Y.S.; Breese, M.B.H.; Bettiol, A.A.

    2009-01-01

    This work reports on the writing of computer generated hologram diffraction patterns using focused 2 MeV proton beam irradiation. These patterns were designed using a ray tracing algorithm and written directly into a thick polymethylmethacrylate layer. When the developed holographic pattern was illuminated with a 650 nm laser it produced a good reconstructed image. This work provides means of forming high-resolution, high aspect ratio holographic images in polymers for applications in data storage using switchable holography.

  8. Proton transport in additives to the polymer electrolyte membrane for fuel cell application

    Energy Technology Data Exchange (ETDEWEB)

    Toelle, Pia

    2011-03-21

    The enhancement of proton transport in polymer electrolyte membranes is an important issue for the development of fuel cell technology. The objective is a material providing proton transport at a temperature range of 350 K to 450 K independent from a purely water based mechanism. To enhance the PEM properties of standard polymer materials, a class of additives is studied by means of atomistic simulations consisting of functionalised mesoporous silicon dioxide particles. The functional molecules are imidazole or sulphonic acid, covalently bound to the surface via a carbon chain with a surface density of about 1.0 nm{sup -2} groups. At first, the proton transport mechanism is explored in a system of functional molecules in vacuum. The molecules are constrained by the terminal carbon groups according to the geometric arrangement in the porous silicon dioxide. The proton transport mechanism is characterised by structural properties obtained from classical molecular dynamics simulations and consists of the aggregation of two or more functional groups, a barrier free proton transport between these groups followed by the separation of the groups and formation of new aggregates due to fluctuations in the hydrogen bond network and movement of the carbon chain. For the different proton conducting groups, i.e. methyl imidazole, methyl sulphonic acid and water, the barrier free proton transport and the formation of protonated bimolecular complexes were addressed by potential energy calculations of the density functional based tight binding method (DFTB). For sulphonic acid even at a temperature of 450 K, relatively stable aggregates are formed, while most imidazole groups are isolated and the hydrogen bond fluctuations are high. However, high density of groups and elevated temperatures enhance the proton transport in both systems. Besides the anchorage and the density of the groups, the influence of the chemical environment on the proton transport was studied. Therefore, the

  9. FEASIBILITY OF POSITRON EMISSION TOMOGRAPHY OF DOSE DISTRIBUTION IN PROTON BEAM CANCER THERAPY

    International Nuclear Information System (INIS)

    BEEBE-WANG, J.J.; DILMANIAN, F.A.; PEGGS, S.G.; SCHLYEER, D.J.; VASKA, P.

    2002-01-01

    Proton therapy is a treatment modality of increasing utility in clinical radiation oncology mostly because its dose distribution conforms more tightly to the target volume than x-ray radiation therapy. One important feature of proton therapy is that it produces a small amount of positron-emitting isotopes along the beam-path through the non-elastic nuclear interaction of protons with target nuclei such as 12 C, 14 N, and 16 O. These radioisotopes, mainly 11 C, 13 N and 15 O, allow imaging the therapy dose distribution using positron emission tomography (PET). The resulting PET images provide a powerful tool for quality assurance of the treatment, especially when treating inhomogeneous organs such as the lungs or the head-and-neck, where the calculation of the dose distribution for treatment planning is more difficult. This paper uses Monte Carlo simulations to predict the yield of positron emitters produced by a 250 MeV proton beam, and to simulate the productions of the image in a clinical PET scanner

  10. Impact of the 7 TeV/c Large Hadron Collider proton beam on a copper target

    CERN Document Server

    Tahir, N A; Goddard, B; Hoffmann, Dieter H H; Kain, V; Lomonosov, I V; Piriz, A R; Schmidt, R; Shutov, A; Temporal, M

    2005-01-01

    The Large Hadron Collider (LHC) will allow for collision between two 7 TeV/c proton beams, each comprising 2808 bunches with 1.1*10/sup 11 / protons per bunch, traveling in opposite direction. The bunch length is 0.5 ns and two neighboring bunches are separated by 25 ns so that the duration of the entire beam is about 89 mu s. The beam power profile in the transverse direction is a Gaussian with a standard deviation of 0.2 mm. The energy stored in each beam is about 350 MJ that is sufficient to melt 500 kg of copper. In case of a failure in the machine protection systems, the entire beam could impact directly onto an accelerator equipment. A first estimate of the scale of damage resulting from such a failure has been assessed for a solid copper target hit by the beam by carrying out three- dimensional energy deposition calculations and two-dimensional numerical simulations of the hydrodynamic and thermodynamic response of the target. This work has shown that the penetration depth of the LHC protons will be be...

  11. Beam transport design for a recirculating-linac FEL driver

    International Nuclear Information System (INIS)

    Neuffer, D.; Douglas, D.; Li, Z.; Cornacchia, M.; Garren, A.

    1996-01-01

    The beam transport system for the CEBAF Industrial FEL includes a two-pass transport of the beam with acceleration from injector to wiggler, followed by energy recovery transport from wiggler to dump. From that context, the authors discuss the general problem of multi-pass energy-recovery beam transport for FELs. Tunable, nearly-isochronous, large-momentum-acceptance transport systems are required. The entire transport must preserve beam quality, particularly in the acceleration transport to the wiggler, and have low losses throughout the entire system. Various possible designs are presented, and results of dynamic analyses are discussed

  12. Investigating proton emitters at the limits of stability with radioactive beams from the Oak Ridge facility

    Energy Technology Data Exchange (ETDEWEB)

    Toth, K.S. [Oak Ridge National Lab., TN (United States); Batchelder, J.C.; Zganjar, E.F. [Louisiana State Univ., Baton Rouge, LA (United States); Bingham, C.R.; Wauters, J. [Tennessee Univ., Knoxville, TN (United States); Davinson, T.; MacKenzie, J.A.; Woods, P.J. [Edinburgh Univ. (United Kingdom)

    1996-10-01

    By using beams from the Holifield Radioactive Ion Beam Facility at ORNL, it should be possible to identify many new ground-state proton emitters in the mass region from Sn to Pb. In these investigations nuclei produced in fusion-evaporation reactions will be separated from incident ions and dispersed in mass/charge with a recoil mass separator and then implanted into a double-sided Si strip detector for study of proton (and {alpha}-particle) radioactivity. This paper summarizes data presently extant on proton emitters and then focuses on tests and initial experiments that will be carried out with stable beams and with radioactive ions as they are developed at the Oak Ridge facility.

  13. Carbon filament beam profile monitor for high energy proton-antiproton storage rings

    International Nuclear Information System (INIS)

    Evans, L.R.; Shafer, R.E.

    1979-01-01

    The measurement of the evolution of the transverse profile of the stored beams in high energy proton storage rings such as the p-anti p colliders at CERN and at FNAL is of considerable importance. In the present note, a simple monitor is discussed which will allow almost non-destructive measurement of the profile of each individual proton and antiproton bunch separately. It is based on the flying wire technique first used at CEA and more recently at the CPS. A fine carbon filament is passed quickly through the beam, acting as a target for secondary particle production. The flux of secondary particles is measured by two scintillator telescopes, one for protons and one for antiprotons, having an angular acceptance between 30 and 100 mrad. Measurements of secondary particle production performed at FNAL in this angular range show that a very respectable flux can be expected

  14. Randomized Clinical Trial Comparing Proton Beam Radiation Therapy with Transarterial Chemoembolization for Hepatocellular Carcinoma: Results of an Interim Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Bush, David A., E-mail: dbush@llu.edu [Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California (United States); Smith, Jason C. [Department of Diagnostic Radiology, Loma Linda University Medical Center, Loma Linda, California (United States); Slater, Jerry D. [Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California (United States); Volk, Michael L. [Transplantation Institute and Liver Center, Loma Linda University Medical Center, Loma Linda, California (United States); Reeves, Mark E. [VA Loma Linda Health Care System, Loma Linda, California (United States); Cheng, Jason [Transplantation Institute and Liver Center, Loma Linda University Medical Center, Loma Linda, California (United States); Grove, Roger [Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California (United States); Vera, Michael E. de [Transplantation Institute and Liver Center, Loma Linda University Medical Center, Loma Linda, California (United States)

    2016-05-01

    Purpose: To describe results of a planned interim analysis of a prospective, randomized clinical trial developed to compare treatment outcomes among patients with newly diagnosed hepatocellular carcinoma (HCC). Methods and Materials: Eligible subjects had either clinical or pathologic diagnosis of HCC and met either Milan or San Francisco transplant criteria. Patients were randomly assigned to transarterial chemoembolization (TACE) or to proton beam radiation therapy. Patients randomized to TACE received at least 1 TACE with additional TACE for persistent disease. Proton beam radiation therapy was delivered to all areas of gross disease to a total dose of 70.2 Gy in 15 daily fractions over 3 weeks. The primary endpoint was progression-free survival, with secondary endpoints of overall survival, local tumor control, and treatment-related toxicities as represented by posttreatment days of hospitalization. Results: At the time of this analysis 69 subjects were available for analysis. Of these, 36 were randomized to TACE and 33 to proton. Total days of hospitalization within 30 days of TACE/proton was 166 and 24 days, respectively (P<.001). Ten TACE and 12 proton patients underwent liver transplantation after treatment. Viable tumor identified in the explanted livers after TACE/proton averaged 2.4 and 0.9 cm, respectively. Pathologic complete response after TACE/proton was 10%/25% (P=.38). The 2-year overall survival for all patients was 59%, with no difference between treatment groups. Median survival time was 30 months (95% confidence interval 20.7-39.3 months). There was a trend toward improved 2-year local tumor control (88% vs 45%, P=.06) and progression-free survival (48% vs 31%, P=.06) favoring the proton beam treatment group. Conclusions: This interim analysis indicates similar overall survival rates for proton beam radiation therapy and TACE. There is a trend toward improved local tumor control and progression-free survival with proton beam. There are

  15. Performance specifications for proton medical facility

    Energy Technology Data Exchange (ETDEWEB)

    Chu, W.T.; Staples, J.W.; Ludewigt, B.A.; Renner, T.R.; Singh, R.P.; Nyman, M.A.; Collier, J.M.; Daftari, I.K.; Petti, P.L.; Alonso, J.R. [Lawrence Berkeley Lab., CA (United States); Kubo, H.; Verhey, L.J. [University of California Davis Medical Center, Sacramento, CA (United States). Cancer Center]|[California Univ., San Francisco, CA (United States). School of Medicine; Castro, J.R. [Lawrence Berkeley Lab., CA (United States)]|[University of California Davis Medical Center, Sacramento, CA (United States). Cancer Center]|[California Univ., San Francisco, CA (United States). School of Medicine

    1993-03-01

    Performance specifications of technical components of a modern proton radiotherapy facility are presented. The technical items specified include: the accelerator; the beam transport system including rotating gantry; the treatment beamline systems including beam scattering, beam scanning, and dosimetric instrumentation; and an integrated treatment and accelerator control system. Also included are treatment ancillary facilities such as diagnostic tools, patient positioning and alignment devices, and treatment planning systems. The facility specified will accommodate beam scanning enabling the three-dimensional conformal therapy deliver .

  16. Dosimetry with the scanned proton beam on the PSI gantry

    International Nuclear Information System (INIS)

    Coray, A.; Pedroni, E.; Boehringer, T.; Lin, S.; Lomax, T.; Goitein, G.

    2002-01-01

    Full text: The irradiation facility at PSI is designed for the treatment of deep seated tumours with a proton beam energy of up to 270 MeV. The spot scanning technique, which uses a proton pencil beam applied to the patient, is performed on a compact isocentric gantry. An optimal three-dimensional conformation of the dose distribution to the target volume can be realized. A fast steering system and a redundant interlock system are in operation. The dose delivery is controlled by a parallel plate transmission chamber, which is calibrated in terms of number of protons per monitor unit. The therapy planning is based on an empirical model, which takes into account attenuation of primary protons and losses outside the primary beam through secondary products. The therapy plan predicts an absolute dose. The calibration of the primary monitor is done using a reference thimble ionization chamber inside a homogeneous geometrical dose volume. The reference system is calibrated in a cobalt field at the national office of metrology in terms of absorbed dose to water. The dosimetry protocol used up to last year was based on the ICRU Report Nr. 59, we have switched to the IAEA Code of Practice starting this beam period. Data on the monitor calibration for various energies and using two different reference systems will be shown. The calibration of the beam monitor using a Faraday Cup in the static pencil beam results in a good agreement with the ionization chamber measurements, with a deviation of less than 1%. Following the daily setup of the machine, an extensive quality control and safety check of the whole system is performed. The daily dosimetry quality assurance program includes: measurement of dose rate and monitor ratios; check of the beam position monitors; measurement of a depth dose curve; dose measurement in a regular dose field. The doses measured daily in a regular scanned field show a standard deviation of about 1 %. Further daily checks results, which illustrate

  17. Fractionated proton beam irradiation of pituitary adenomas

    International Nuclear Information System (INIS)

    Ronson, Brian B.; Schulte, Reinhard W.; Han, Khanh P.; Loredo, Lilia N.; Slater, James M.; Slater, Jerry D.

    2006-01-01

    Purpose: Various radiation techniques and modalities have been used to treat pituitary adenomas. This report details our experience with proton treatment of these tumors. Methods and Materials: Forty-seven patients with pituitary adenomas treated with protons, who had at least 6 months of follow-up, were included in this analysis. Forty-two patients underwent a prior surgical resection; 5 were treated with primary radiation. Approximately half the tumors were functional. The median dose was 54 cobalt-gray equivalent. Results: Tumor stabilization occurred in all 41 patients available for follow-up imaging; 10 patients had no residual tumor, and 3 had greater than 50% reduction in tumor size. Seventeen patients with functional adenomas had normalized or decreased hormone levels; progression occurred in 3 patients. Six patients have died; 2 deaths were attributed to functional progression. Complications included temporal lobe necrosis in 1 patient, new significant visual deficits in 3 patients, and incident hypopituitarism in 11 patients. Conclusion: Fractionated conformal proton-beam irradiation achieved effective radiologic, endocrinological, and symptomatic control of pituitary adenomas. Significant morbidity was uncommon, with the exception of postradiation hypopituitarism, which we attribute in part to concomitant risk factors for hypopituitarism present in our patient population

  18. Crystal Collimation Cleaning Measurements with Proton Beams in LHC

    CERN Document Server

    Rossi, Roberto; Andreassen, Odd Oyvind; Butcher, Mark; Dionisio Barreto, Cristovao Andre; Masi, Alessandro; Mirarchi, Daniele; Montesano, Simone; Lamas Garcia, Inigo; Redaelli, Stefano; Scandale, Walter; Serrano Galvez, Pablo; Rijllart, Adriaan; Valentino, Gianluca; CERN. Geneva. ATS Department

    2016-01-01

    During this MD, performed on July 29th, 2016, bent silicon crystal were tested with proton beams for a possible usage of crystal-assisted collimation. Tests were performed at both injection energy and flat top using horizontal and vertical crystal. Loss maps with crystals at 6.5 TeV were measured.

  19. Implementation of pencil kernel and depth penetration algorithms for treatment planning of proton beams

    International Nuclear Information System (INIS)

    Russell, K.R.; Saxner, M.; Ahnesjoe, A.; Montelius, A.; Grusell, E.; Dahlgren, C.V.

    2000-01-01

    The implementation of two algorithms for calculating dose distributions for radiation therapy treatment planning of intermediate energy proton beams is described. A pencil kernel algorithm and a depth penetration algorithm have been incorporated into a commercial three-dimensional treatment planning system (Helax-TMS, Helax AB, Sweden) to allow conformal planning techniques using irregularly shaped fields, proton range modulation, range modification and dose calculation for non-coplanar beams. The pencil kernel algorithm is developed from the Fermi-Eyges formalism and Moliere multiple-scattering theory with range straggling corrections applied. The depth penetration algorithm is based on the energy loss in the continuous slowing down approximation with simple correction factors applied to the beam penumbra region and has been implemented for fast, interactive treatment planning. Modelling of the effects of air gaps and range modifying device thickness and position are implicit to both algorithms. Measured and calculated dose values are compared for a therapeutic proton beam in both homogeneous and heterogeneous phantoms of varying complexity. Both algorithms model the beam penumbra as a function of depth in a homogeneous phantom with acceptable accuracy. Results show that the pencil kernel algorithm is required for modelling the dose perturbation effects from scattering in heterogeneous media. (author)

  20. Development of abiotic-stress resistant warm season trufgrasses by proton-beam irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Y. W.; Kim, J. Y.; Jeong, S. H. [Korea Univ., Seoul (Korea, Republic of)

    2007-04-15

    The direct use of mutation is a valuable approach to generate genetic variation in crop species by altering agronomically useful major traits. The proton beam, as a mutagen, was applied to improve resistance traits of Zoysia grass under various abiotic stresses. Proton beam was irradiated to mature dry seeds of Zenith (Zoysia grass), which is well-adapted to Korean climate, using a proton- accelerator with seven different doses (50, 100, 150, 200, 250, 300, 400 Gy). Individual seedling of M1 plant was transplanted from the seed bed and allowed to reach appropriate plant mass. Clones that showed superior growth were chosen and transplanted to pots for further clone propagation and field evaluation. Growth characteristics of turfgrass, such as plant height, leaf length, leaf width, number of tiller were evaluated ninety days after sowing. Although large variation within each dose, noticeable differences were found among different irradiated doses. Most of the mutant clones derived from the irradiation treatment showed more vigorous growth than the control plants. RAPD (Random Amplified Polymorphic DNA) and AFLP (Amplified Fragment Length Polymorphism) methods were conducted to analyze genomic variations associated with proton beam irradiation. In order to establish selection criteria for selection of salt-stress resistance plants, an in vitro method that is able to select salt-stress resistant mutants in liquid media without ambient disturbances. Total 647 predominance clones that were considered as abiotic stress resistant mutants were transplanted to the field for further evaluation.

  1. Development of ion/proton beam equipment for industrial uses

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Byung Ho; Lee, J. H.; Cho, Y. S.; Joo, P. K.; Kang, S. S.; Song, W. S.; Kim, H. J.; Chang, G. H.; Bang, S. W

    1999-12-01

    KAERI has possessed design and fabrication technologies of various ion sources including Duoplasmatron and DuoPiGatron developed by R and D projects of the long-term nuclear technology development program. In order to industrialize ion beam equipments utilizing these ion sources, a technology transfer project for a technology transfer project for a domestic firm has been performed. Under this project, engineers of the firm have been trained through classroom lectures of ion beam principles and OJT, an ion/proton beam equipment (DEMO equipment) has been designed, assembled and commissioned jointly with the engineers. Quality of the ion sources has been quantified, and technologies for ion beam equipment construction, functional test and application research have been developed. The DEMO equipment, which consists of an ion source, power supplies, vacuum, cooling and target systems, has been fabricated and tested to secure stability and reliability for industrial uses. Various characteristic tests including high voltage insulation, beam extraction, beam current measuring, etc. have been performed. This DEMO can be utilized for ion sources development as well as ion beam process development for various industrial products. Engineers of the firm have been trained for the industrialization of ion beam equipment and joined in beam application technology development to create industrial needs of beam equipment. (author)

  2. Experimental determination of the complete spin structure for anti-proton + proton -> anti-\\Lambda + \\Lambda at anti-proton beam momentum of 1.637 GeV/c

    CERN Document Server

    Paschke, K.D.; Berdoz, A.; Franklin, G.B.; Khaustov, P.; Meyer, C.A.; Bradtke, C.; Gehring, R.; Goertz, S.; Harmsen, J.; Meier, A.; Meyer, W.; Radtke, E.; Reicherz, G.; Dutz, H.; Pluckthun, M.; Schoch, B.; Dennert, H.; Eyrich, W.; Hauffe, J.; Metzger, A.; Moosburger, M.; Stinzing, F.; Wirth, St.; Fischer, H.; Franz, J.; Heinsius, F.H.; Kriegler, E.; Schmitt, H.; Bunker, B.; Hertzog, D.; Jones, T.; Tayloe, R.; Broders, R.; Geyer, R.; Kilian, K.; Oelert, W.; Rohrich, K.; Sachs, K.; Sefzick, T.; Bassalleck, B.; Eilerts, S.; Fields, D.E.; Kingsberry, P.; Lowe, J.; Stotzer, R.; Johansson, T.; Pomp, S.; Wirth, St.

    2006-01-01

    The reaction anti-proton + proton -> anti-\\Lambda + \\Lambda -> anti-proton + \\pi^+ + proton + \\pi^- has been measured with high statistics at anti-proton beam momentum of 1.637 GeV/c. The use of a transversely-polarized frozen-spin target combined with the self-analyzing property of \\Lambda/anti-\\Lambda decay allows access to unprecedented information on the spin structure of the interaction. The most general spin-scattering matrix can be written in terms of eleven real parameters for each bin of scattering angle, each of these parameters is determined with reasonable precision. From these results all conceivable spin-correlations are determined with inherent self-consistency. Good agreement is found with the few previously existing measurements of spin observables in anti-proton + proton -> anti-\\Lambda + \\Lambda near this energy. Existing theoretical models do not give good predictions for those spin-observables that had not been previously measured.

  3. A laser-wire beam-energy and beam-profile monitor at the BNL linac

    Energy Technology Data Exchange (ETDEWEB)

    Connolly, R.; Degen, C.; DeSanto, L.; Meng, W.; Michnoff, R.; Minty, M.; Nayak, S.

    2011-03-28

    In 2009 a beam-energy monitor was installed in the high energy beam transport (HEBT) line at the Brookhaven National Lab linac. This device measures the energies of electrons stripped from the 40mA H{sup -} beam by background gas. Electrons are stripped by the 2.0x10{sup -7}torr residual gas at a rate of {approx}1.5x10{sup -8}/cm. Since beam electrons have the same velocities as beam protons, the beam proton energy is deduced by multiplying the electron energy by m{sub p}/m{sub e}=1836. A 183.6MeV H{sup -} beam produces 100keV electrons. In 2010 we installed an optics plates containing a laser and scanning optics to add beam-profile measurement capability via photodetachment. Our 100mJ/pulse, Q-switched laser neutralizes 70% of the beam during its 10ns pulse. This paper describes the upgrades to the detector and gives profile and energy measurements.

  4. Polarized proton beam for eRHIC

    Energy Technology Data Exchange (ETDEWEB)

    Huang, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Meot, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ptitsyn, V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Roser, T. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    RHIC has provided polarized proton collisions from 31 GeV to 255 GeV in the past decade. To preserve polarization through numerous depolarizing resonances through the whole accelerator chain, harmonic orbit correction, partial snakes, horizontal tune jump system and full snakes have been used. In addition, close attentions have been paid to betatron tune control, orbit control and beam line alignment. The polarization of 60% at 255 GeV has been delivered to experiments with 1.8×1011 bunch intensity. For the eRHIC era, the beam brightness has to be maintained to reach the desired luminosity. Since we only have one hadron ring in the eRHIC era, existing spin rotator and snakes can be converted to six snake configuration for one hadron ring. With properly arranged six snakes, the polarization can be maintained at 70% at 250 GeV. This paper summarizes the effort and plan to reach high polarization with small emittance for eRHIC.

  5. Proton Drivers for neutrino beams and other high intensity applications

    CERN Document Server

    Garoby, R; Koseki, T; Thomason, J

    2013-01-01

    CERN, Fermilab, J-PARC and RAL tentatively plan to have proton accelerators delivering multi-MW of beam power in view of enhancing their physics reach especially in the domain of neutrinos. These plans are described, together with their benefits for other applications.

  6. Bragg peak proton beam treatment of arteriovenous malformations of the brain

    International Nuclear Information System (INIS)

    Kjellberg, R.N.; Poletti, C.E.; Roberson, G.H.; Adams, R.D.

    1978-01-01

    This report describes 27 patients treated for arteriovenous malformations of the brain by the Bragg Peak proton beam method during the past 12 years. The authors are led to a measure of confidence that Bragg Peak proton therapy can be provided without lethal risk attributed to the procedure. In 21 patients no neurological change has occurred, two patients experienced neurological improvement and four have developed new neurological abnormalities considered complications of the therapy. (Auth.)

  7. Dynamics of intense pulsed proton beam in the Nagaoka ETIGO-I

    International Nuclear Information System (INIS)

    Tanaka, Hajime; Konno, Kohji; Masugata, Katsumi; Yatsui, Kiyoshi; Matsui, Masao

    1982-01-01

    Dynamics of an intense pulsed proton beam have been studied by measuring nuclear reactions as well as by a biased ion-collector (BIC). When the ion-current density (Jsub(i)) is small such that Jsub(i) lt 30 A/cm 2 , the proton numer measured by BIC is in good agreement with that by nuclear activation. Good linearity exists between time integrated gamma -ray signal and proton number measured by the activation. Hence, it would be possible to obtain the proton number quantitatively even when a target ''blow-off'' takes place at Jsub(i) gt 1 kA/cm 2 . Prompt gamma -ray is also measured by the time-of-flight method to yield reasonable agreement with the applied peak potential. (author)

  8. Beam Dynamics Studies for High-Intensity Beams in the CERN Proton Synchrotron

    CERN Document Server

    AUTHOR|(CDS)2082016; Benedikt, Michael

    With the discovery of the Higgs boson, the existence of the last missing piece of the Standard Model of particle physics (SM) was confirmed. However, even though very elegant, this theory is unable to explain, for example, the generation of neutrino masses, nor does it account for dark energy or dark matter. To shed light on some of these open questions, research in fundamental particle physics pursues two complimentary approaches. On the one hand, particle colliders working at the high-energy frontier, such as the Large Hadron Collider (LHC) at the European Organization for Nuclear Research (CERN), located in Geneva, Switzerland, are utilized to investigate the fundamental laws of nature. Alternatively, fixed target facilities require high-intensity beams to create a large flux of secondary particles to investigate, for example, rare particle decay processes, or to create neutrino beams. This thesis investigates limitations arising during the acceleration of high-intensity beams at the CERN Proton Synchrotro...

  9. Basic Research and Feasibility Study of Radioisotope Production using 100 MeV Proton Beam

    International Nuclear Information System (INIS)

    Yoo, K. H.; Yoon, K. S.; Cho, W. J.; Park, S. I.; Han, H. S.; Yang, S. D.; Jeon, K. S.; Kim, J. H.; Yang, T. K.

    2010-04-01

    Results of the project are various nuclei, such as 82 Rb, 68 Ga, 67 Cu, 22 Na and so on, can be produced by irradiating 100 MeV proton beam, by irradiating proton beam to the nat Ga target, the 68 Ge, mother nucleus of positron emitting 68 Ga, is produced based on the nat Ga(p,x) 68 Ge reaction, the target system for the high-energy of proton beam can produce more than 2 species of radioisotope at the same time by employing tandem targets, 68 Ge/ 68 Ga generator, 82 Sr(25.34d)/ 82 Rb generator - 67 Cu production method, 70 Zn electroplating technology based on the electrochemistry, the container, whose weight is about 3 ton, is made by depleted uranium and because of the unstable situation for the supply and demand of reactor produced radioisotope, the need for the cyclotron produced radioisotopes is dramatically increased all over the world.

  10. Shielding measurements for a 230 MeV proton beam

    International Nuclear Information System (INIS)

    Siebers, J.V.

    1990-01-01

    Energetic secondary neutrons produced as protons interact with accelerator components and patients dominate the radiation shielding environment for proton radiotherapy facilities. Due to the scarcity of data describing neutron production, attenuation, absorbed dose, and dose equivalent values, these parameters were measured for 230 MeV proton bombardment of stopping length Al, Fe, and Pb targets at emission angles of 0 degree, 22 degree, 45 degree, and 90 degree in a thick concrete shield. Low pressure tissue-equivalent proportional counters with volumes ranging from 1 cm 3 to 1000 cm 3 were used to obtain microdosimetric spectra from which absorbed dose and radiation quality are deduced. Does equivalent values and attenuation lengths determined at depth in the shield were found to vary sharply with angle, but were found to be independent of target material. Neutron dose and radiation length values are compared with Monte Carlo neutron transport calculations performed using the Los Alamos High Energy Transport Code (LAHET). Calculations used 230 MeV protons incident upon an Fe target in a shielding geometry similar to that used in the experiment. LAHET calculations overestimated measured attenuation values at 0 degree, 22 degree, and 45 degree, yet correctly predicted the attenuation length at 90 degree. Comparison of the mean radiation quality estimated with the Monte Carlo calculations with measurements suggest that neutron quality factors should be increased by a factor of 1.4. These results are useful for the shielding design of new facilities as well as for testing neutron production and transport calculations

  11. Resonant beam behavior studies in the Proton Storage Ring

    Directory of Open Access Journals (Sweden)

    S. Cousineau

    2003-07-01

    Full Text Available We present studies of space-charge-induced beam profile broadening at high intensities in the Proton Storage Ring (PSR at Los Alamos National Laboratory. We investigate the profile broadening through detailed particle-in-cell simulations of several experiments and obtain results in good agreement with the measurements. We interpret these results within the framework of coherent resonance theory. With increasing intensity, our simulations show strong evidence for the presence of a quadrupole-mode resonance of the beam envelope with the lattice in the vertical plane. Specifically, we observe incoherent tunes crossing integer values, and large amplitude, nearly periodic envelope oscillations. At the highest operating intensities, we observe a continuing relaxation of the beam through space charge forces leading to emittance growth. The increase of emittance commences when the beam parameters encounter an envelope stop band. Once the stop band is reached, the emittance growth balances the intensity increase to maintain the beam near the stop band edge. Additionally, we investigate the potential benefit of a stop band correction to the high intensity PSR beam.

  12. Radial focusing and energy compression of a laser-produced proton beam by a synchronous rf field

    Directory of Open Access Journals (Sweden)

    Masahiro Ikegami

    2009-06-01

    Full Text Available The dynamics of a MeV laser-produced proton beam affected by a radio frequency (rf electric field has been studied. The proton beam was emitted normal to the rear surface of a thin polyimide target irradiated with an ultrashort pulsed laser with a power density of 4×10^{18}  W/cm^{2}. The energy spread was compressed to less than 11% at the full width at half maximum (FWHM by an rf field. Focusing and defocusing effects of the transverse direction were also observed. These effects were analyzed and reproduced by Monte Carlo simulations. The simulation results show that the transversely focused protons had a broad continuous spectrum, while the peaks in the proton spectrum were defocused. Based on this new information, we propose that elimination of the continuous energy component of laser-produced protons is possible by utilizing a focal length difference between the continuous spectral protons and the protons included in the spectral peak.

  13. Kinetics of proton transport into influenza virions by the viral M2 channel.

    Directory of Open Access Journals (Sweden)

    Tijana Ivanovic

    Full Text Available M2 protein of influenza A viruses is a tetrameric transmembrane proton channel, which has essential functions both early and late in the virus infectious cycle. Previous studies of proton transport by M2 have been limited to measurements outside the context of the virus particle. We have developed an in vitro fluorescence-based assay to monitor internal acidification of individual virions triggered to undergo membrane fusion. We show that rimantadine, an inhibitor of M2 proton conductance, blocks the acidification-dependent dissipation of fluorescence from a pH-sensitive virus-content probe. Fusion-pore formation usually follows internal acidification but does not require it. The rate of internal virion acidification increases with external proton concentration and saturates with a pK(m of ∼4.7. The rate of proton transport through a single, fully protonated M2 channel is approximately 100 to 400 protons per second. The saturating proton-concentration dependence and the low rate of internal virion acidification derived from authentic virions support a transporter model for the mechanism of proton transfer.

  14. Beam tests of prototype fiber detectors for the H1 forward proton spectrometer

    International Nuclear Information System (INIS)

    Baehr, J.; Hiller, K.; Hoffmann, B.; Luedecke, H.; Menchikov, A.; Nahnhauer, R.; Roloff, H.E.; Tonisch, F.; Voelkert, R.

    1994-07-01

    Different prototypes of fiber detectors with an internal trigger system were tested in a 5 GeV electron beam at DESY. A silicon microstrip telescope was used for an external reference measurement of the beam to study the spatial resolution of the fiber detectors. On average 75% of all crossing electron tracks could be reconstructed with a precision better than 150 μm. These successful methodical investigations led to the installation of similar detectors in the proton beamline 81 m downstream of the central H1-detector at HERA as part of a forward proton spectrometer in spring 1994. (orig.)

  15. Beam tests of prototype fiber detectors for the H1 forward proton spectrometer

    International Nuclear Information System (INIS)

    Baehr, J.; Hiller, K.; Hoffmann, B.; Luedecke, H.; Menchikov, A.; Nahnhauer, R.; Roloff, H.E.; Tonisch, F.; Voelkert, R.

    1995-01-01

    Different prototypes of fiber detectors with an internal trigger system were tested in a 5 GeV electron beam at DESY. A silicon microstrip telescope was used for an external reference measurement of the beam to study the spatial resolution of the fiber detectors. On average 75% of all crossing electron tracks could be reconstructed with a precision better than 150 μm. These successful methodical investigations led to the installation of similar detectors in the proton beamline 81 m downstream of the central H1-detector at HERA as part of a forward proton spectrometer in spring 1994. (orig.)

  16. Proton beam therapy in the management of skull base chordomas: systematic review of indications, outcomes, and implications for neurosurgeons.

    Science.gov (United States)

    Matloob, Samir A; Nasir, Haleema A; Choi, David

    2016-08-01

    Chordomas are rare tumours affecting the skull base. There is currently no clear consensus on the post-surgical radiation treatments that should be used after maximal tumour resection. However, high-dose proton beam therapy is an accepted option for post-operative radiotherapy to maximise local control, and in the UK, National Health Service approval for funding abroad is granted for specific patient criteria. To review the indications and efficacy of proton beam therapy in the management of skull base chordomas. The primary outcome measure for review was the efficacy of proton beam therapy in the prevention of local occurrence. A systematic review of English and non-English articles using MEDLINE (1946-present) and EMBASE (1974-present) databases was performed. Additional studies were reviewed when referenced in other studies and not available on these databases. Search terms included chordoma or chordomas. The PRISMA guidelines were followed for reporting our findings as a systematic review. A total of 76 articles met the inclusion and exclusion criteria for this review. Limitations included the lack of documentation of the extent of primary surgery, tumour size, and lack of standardised outcome measures. Level IIb/III evidence suggests proton beam therapy given post operatively for skull base chordomas results in better survival with less damage to surrounding tissue. Proton beam therapy is a grade B/C recommended treatment modality for post-operative radiation therapy to skull base chordomas. In comparison to other treatment modalities long-term local control and survival is probably improved with proton beam therapy. Further, studies are required to directly compare proton beam therapy to other treatment modalities in selected patients.

  17. Anisotropic amplification of proton transport in proton exchange membrane fuel cells

    Science.gov (United States)

    Thimmappa, Ravikumar; Fawaz, Mohammed; Devendrachari, Mruthyunjayachari Chattanahalli; Gautam, Manu; Kottaichamy, Alagar Raja; Shafi, Shahid Pottachola; Thotiyl, Musthafa Ottakam

    2017-07-01

    Though graphene oxide (GO) membrane shuttles protons under humid conditions, it suffer severe disintegration and anhydrous conditions lead to abysmal ionic conductivity. The trade-off between mechanical integrity and ionic conductivity challenge the amplification of GO's ionic transport under anhydrous conditions. We show anisotropic amplification of GO's ionic transport with a selective amplification of in plane contribution under anhydrous conditions by doping it with a plant extract, phytic acid (PA). The hygroscopic nature of PA stabilized interlayer water molecules and peculiar geometry of sbnd OH functionalities around saturated hydrocarbon ring anisotropically enhanced ionic transport amplifying the fuel cell performance metrics.

  18. Beam dynamics and commissioning of low and medium energy H- beam at Linac4

    CERN Document Server

    Satri, Masoomeh Yarmohammadi; Lombardi, Alessandra; Lamehi-Rachti , Mohammad

    The First step of the CERN Large Hadron Collider injectors upgrade (LIU) project is Linac4. It accelerates H- ions to 160 MeV in an 80 m long accelerator housed in a tunnel 12 m underground, presently under construction. It will replace the present 50 MeV proton Linac2 as injector of the proton accelerator complex to increase the LHC luminosity. It consists of a 45 keV RF volume source, a twosolenoid Low Energy Beam Transport (LEBT), a 352.2 MHz Radio Frequency Quadrupole (RFQ) accelerating the beam to 3 MeV, a Medium Energy Beam Transport (MEBT) line. The MEBT houses a fast chopper to selectively remove unwanted micro-bunches in the 352 MHz sequence and avoid losses at capture in the CERN PSB (1 MHz). After chopping, the beam acceleration continues by a 50 MeV Drift Tube Linac (DTL), a 100 MeV Cell-Coupled Drift Tube Linac and a Pi-Mode Structure bringing the beam to the final energy of 160 MeV. Linac4 has been commissioned with a temporary source up to 12 MeV. The beam commissioning stages of Linac4 in LEBT...

  19. Transport and energy selection of laser generated protons for postacceleration with a compact linac

    Directory of Open Access Journals (Sweden)

    Stefano Sinigardi

    2013-03-01

    Full Text Available Laser accelerated proton beams have a considerable potential for various applications including oncological therapy. However, the most consolidated target normal sheath acceleration regime based on irradiation of solid targets provides an exponential energy spectrum with a significant divergence. The low count number at the cutoff energy seriously limits at present its possible use. One realistic scenario for the near future is offered by hybrid schemes. The use of transport lines for collimation and energy selection has been considered. We present here a scheme based on a high field pulsed solenoid and collimators which allows one to select a beam suitable for injection at 30 MeV into a compact linac in order to double its energy while preserving a significant intensity. The results are based on a fully 3D simulation starting from laser acceleration.

  20. Development of the compact proton beam therapy system dedicated to spot scanning with real-time tumor-tracking technology

    Science.gov (United States)

    Umezawa, Masumi; Fujimoto, Rintaro; Umekawa, Tooru; Fujii, Yuusuke; Takayanagi, Taisuke; Ebina, Futaro; Aoki, Takamichi; Nagamine, Yoshihiko; Matsuda, Koji; Hiramoto, Kazuo; Matsuura, Taeko; Miyamoto, Naoki; Nihongi, Hideaki; Umegaki, Kikuo; Shirato, Hiroki

    2013-04-01

    Hokkaido University and Hitachi Ltd. have started joint development of the Gated Spot Scanning Proton Therapy with Real-Time Tumor-Tracking System by integrating real-time tumor tracking technology (RTRT) and the proton therapy system dedicated to discrete spot scanning techniques under the "Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program)". In this development, we have designed the synchrotron-based accelerator system by using the advantages of the spot scanning technique in order to realize a more compact and lower cost proton therapy system than the conventional system. In the gated irradiation, we have focused on the issues to maximize irradiation efficiency and minimize the dose errors caused by organ motion. In order to understand the interplay effect between scanning beam delivery and target motion, we conducted a simulation study. The newly designed system consists of the synchrotron, beam transport system, one compact rotating gantry treatment room with robotic couch, and one experimental room for future research. To improve the irradiation efficiency, the new control function which enables multiple gated irradiations per synchrotron cycle has been applied and its efficacy was confirmed by the irradiation time estimation. As for the interplay effect, we confirmed that the selection of a strict gating width and scan direction enables formation of the uniform dose distribution.

  1. TRANSPORT: a computer program for designing charged particle beam transport systems

    International Nuclear Information System (INIS)

    Brown, K.L.; Rothacker, F.; Carey, D.C.; Iselin, C.

    1977-05-01

    TRANSPORT is a first- and second-order matrix multiplication computer program intended for the design of static-magnetic beam transport systems. It has been in existence in various evolutionary versions since 1963. The present version, described in the manual given, includes both first- and second-order fitting capabilities. TRANSPORT will step through the beam line, element by element, calculating the properties of the beam or other quantities, described below, where requested. Therefore one of the first elements is a specification of the phase space region occupied by the beam entering the system. Magnets and intervening spaces and other elements then follow in the sequence in which they occur in the beam line. Specifications of calculations to be done or of configurations other than normal are placed in the same sequence, at the point where their effect is to be made

  2. Physical measurements with a high-energy proton beam using liquid and solid tissue substitutes

    International Nuclear Information System (INIS)

    Constantinou, C.; Kember, N.F.; Huxtable, G.; Whitehead, C.

    1980-01-01

    The measurement of the physical parameters of a high-energy proton beam, using a range of liquid and solid tissue substitutes, is described. The system, the detectors used and the experimental verification of the tissue equivalence of the new tissue substitutes is presented. The measurements with the scattered but uncollimated proton beam in muscle-and brain-equivalent liquids and in water are compared to similar data obtained from the scattered but collimated beam. The effect of lung, fat and bone on the dose distributions in composite phantoms is also investigated and the necessary corrections established. A simulated patient treatment indicated that the Bragg peak can be positioned with an error not exceeding +-0.5 mm. (author)

  3. Experimental results on transport and focusing of laser accelerated protons

    Energy Technology Data Exchange (ETDEWEB)

    Busold, Simon; Deppert, Oliver; Roth, Markus [TU Darmstadt, IKP, Schlossgartenstr. 9, 64289 Darmstadt (Germany); Schumacher, Dennis; Blazevic, Abel; Zielbauer, Bernhard; Hofmann, Ingo; Bagnoud, Vincent [GSI Helmholtzzentrum fuer Schwerionenforschung, Planckstr. 1, 64291 Darmstadt (Germany); Brabetz, Christian; Al-Omari, Husam [JWG Universitaet Frankfurt, IAP, Max von Laue Str. 1, 60438 Frankfurt am Main (Germany); Joost, Martin; Kroll, Florian; Cowan, Tom [Helmholtzzentrum Dresden-Rossendorf, Bautzner Landstr. 400, 01328 Dresden (Germany); Collaboration: LIGHT-Collaboration

    2013-07-01

    Irradiation of thin foils with high-intensity laser pulses became a reliable tool during the last decade for producing high-intensity proton bunches in about a pico-second from a sub-millimeter source. However, the energy distribution is of an exponential shape with a currently achievable cut-off energy <100 MeV (TNSA mechanism) and the beam is highly divergent with an energy-dependent envelope-divergence of up to 60 deg. Thus, for most applications it is necessary to be able to capture and control these protons as well as select a specific energy. In the frame of the LIGHT collaboration, experimental studies were done at the PHELIX laser at GSI Darmstadt using a pulsed high-field solenoid and alternatively a permanent magnet quadrupole triplet in order to match the beam for injection into a RF cavity. The beam was characterized at several distances after the source and the results are compared to particle tracking simulations.

  4. Status of intense permanent magnet proton source for China-accelerator driven sub-critical system Linac.

    Science.gov (United States)

    Wu, Q; Ma, H Y; Yang, Y; Sun, L T; Zhang, X Z; Zhang, Z M; Zhao, H Y; He, Y; Zhao, H W

    2016-02-01

    Two compact intense 2.45 GHz permanent magnet proton sources and their corresponding low energy beam transport (LEBT) system were developed successfully for China accelerator driven sub-critical system in 2014. Both the proton sources operate at 35 kV potential. The beams extracted from the ion source are transported by the LEBT, which is composed of two identical solenoids, to the 2.1 MeV Radio-Frequency Quadrupole (RFQ). In order to ensure the safety of the superconducting cavities during commissioning, an electrostatic-chopper has been designed and installed in the LEBT line that can chop the continuous wave beam into a pulsed one. The minimum width of the pulse is less than 10 μs and the fall/rise time of the chopper is about 20 ns. The performance of the proton source and the LEBT, such as beam current, beam profile, emittance and the impact to RFQ injection will be presented.

  5. Status of intense permanent magnet proton source for China-accelerator driven sub-critical system Linac

    Science.gov (United States)

    Wu, Q.; Ma, H. Y.; Yang, Y.; Sun, L. T.; Zhang, X. Z.; Zhang, Z. M.; Zhao, H. Y.; He, Y.; Zhao, H. W.

    2016-02-01

    Two compact intense 2.45 GHz permanent magnet proton sources and their corresponding low energy beam transport (LEBT) system were developed successfully for China accelerator driven sub-critical system in 2014. Both the proton sources operate at 35 kV potential. The beams extracted from the ion source are transported by the LEBT, which is composed of two identical solenoids, to the 2.1 MeV Radio-Frequency Quadrupole (RFQ). In order to ensure the safety of the superconducting cavities during commissioning, an electrostatic-chopper has been designed and installed in the LEBT line that can chop the continuous wave beam into a pulsed one. The minimum width of the pulse is less than 10 μs and the fall/rise time of the chopper is about 20 ns. The performance of the proton source and the LEBT, such as beam current, beam profile, emittance and the impact to RFQ injection will be presented.

  6. Status of intense permanent magnet proton source for China-accelerator driven sub-critical system Linac

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Q., E-mail: wuq@impcas.ac.cn; Ma, H. Y.; Yang, Y.; Sun, L. T.; Zhang, X. Z.; Zhang, Z. M.; Zhao, H. Y.; He, Y.; Zhao, H. W. [Institute of Modern Physics (IMP), Chinese Academy of Sciences, Lanzhou 730000 (China)

    2016-02-15

    Two compact intense 2.45 GHz permanent magnet proton sources and their corresponding low energy beam transport (LEBT) system were developed successfully for China accelerator driven sub-critical system in 2014. Both the proton sources operate at 35 kV potential. The beams extracted from the ion source are transported by the LEBT, which is composed of two identical solenoids, to the 2.1 MeV Radio-Frequency Quadrupole (RFQ). In order to ensure the safety of the superconducting cavities during commissioning, an electrostatic-chopper has been designed and installed in the LEBT line that can chop the continuous wave beam into a pulsed one. The minimum width of the pulse is less than 10 μs and the fall/rise time of the chopper is about 20 ns. The performance of the proton source and the LEBT, such as beam current, beam profile, emittance and the impact to RFQ injection will be presented.

  7. The rapid secondary electron imaging system of the proton beam writer at CIBA

    International Nuclear Information System (INIS)

    Udalagama, C.N.B.; Bettiol, A.A.; Kan, J.A. van; Teo, E.J.; Watt, F.

    2007-01-01

    The recent years have witnessed a proliferation of research involving proton beam (p-beam) writing. This has prompted investigations into means of optimizing the process of p-beam writing so as to make it less time consuming and more efficient. One such avenue is the improvement of the pre-writing preparatory procedures that involves beam focusing and sample alignment which is centred on acquiring images of a resolution standard or sample. The conventional mode of imaging used up to now has utilized conventional nuclear microprobe signals that are of a pulsed nature and are inherently slow. In this work, we report the new imaging system that has been introduced, which uses proton induced secondary electrons. This in conjunction with software developed in-house that uses a National Instruments DAQ card with hardware triggering, facilitates large data transfer rates enabling rapid imaging. Frame rates as much as 10 frames/s have been achieved at an imaging resolution of 512 x 512 pixels

  8. Characterization of the IOTA Proton Source

    Energy Technology Data Exchange (ETDEWEB)

    Young, Samantha [Chicago U.

    2017-08-11

    This project focuses on characterizing the IOTA proton source through changing the parameters of four various components of the Low Energy Beam Transport (LEBT). Because of an inecient lament, current was limited to 2 mA when 40 mA is ultimately desired. Through an investigation of the solenoids and trims of the LEBT, we sought more knowledge about the optimum settings for running the IOTA proton source.

  9. Biological intercomparison using gut crypt survivals for proton and carbon-ion beams

    International Nuclear Information System (INIS)

    Uzawa, Akiko; Ando, Koichi; Furusawa, Yoshiya

    2007-01-01

    Charged particle therapy depends on biological information for the dose prescription. Relative biological effectiveness or RBE for this requirement could basically be provided by experimental data. As RBE values of protons and carbon ions depend on several factors such as cell/tissue type, biological endpoint, dose and fractionation schedule, a single RBE value could not deal with all different radiosensitivities. However, any biological model with accurate reproducibility is useful for comparing biological effectiveness between different facilities. We used mouse gut crypt survivals as endpoint, and compared the cell killing efficiency of proton beams at three Japanese facilities. Three Linac X-ray machines with 4 and 6 MeV were used as reference beams, and there was only a small variation (coefficient of variance<2%) in biological effectiveness among them. The RBE values of protons relative to Linac X-rays ranged from 1.0 to 1.11 at the middle of a 6-cm SOBP (spread-out Bragg peak) and from 0.96 to 1.01 at the entrance plateau. The coefficient of variance for protons ranged between 4.0 and 5.1%. The biological comparison of carbon ions showed fairly good agreement in that the difference in biological effectiveness between National Institute of Radiological Sciences (NIRS)/ Heavy Ion Medical Accelerator in Chiba (HIMAC) and Gesellschaft fur Schwerionenforschung (GSI)/Heavy Ion Synchrotron (SIS) was 1% for three positions within the 6-cm SOBP. The coefficient of variance was <1.7, <0.6 and <1.6% for proximal, middle and distal SOBP, respectively. We conclude that the inter-institutional variation of biological effectiveness is smaller for carbon ions than protons, and that beam-spreading methods of carbon ions do not critically influence gut crypt survival. (author)

  10. Space charge and beam stability issues of the Fermilab proton driver in Phase I

    Energy Technology Data Exchange (ETDEWEB)

    K. Y. Ng

    2001-08-24

    Issues concerning beam stability of the proposed Fermilab Proton Driver are studied in its Phase I. Although the betatron tune shifts are dominated by space charge, these shifts are less than 0.25 and will therefore not drive the symmetric and antisymmetric modes of the beam envelope into instability. The longitudinal space charge force is large and inductive inserts may be needed to compensate for the distortion of the rf potential. Although the longitudinal impedance is space charge dominated, it will not drive any microwave instability, unless the real part of the impedance coming from the inductive inserts and wall resistivity of the beam tube are large enough. The design of the beam tube is therefore very important in order to limit the flow of eddy current and keep wall resistivity low. The transverse impedance is also space charge dominated. With the Proton Driver operated at an imaginary transition gamma, however, Landau damping will never be canceled and beam stability can be maintained with negative chromaticities.

  11. Beam transport

    International Nuclear Information System (INIS)

    1988-01-01

    Considerable experience has now been gained with the various beam transport lines, and a number of minor changes have been made to improve the ease of operation. These include: replacement of certain little-used slits by profile monitors (harps or scanners); relocation of steering magnets, closer to diagnostic harps or profile scanners; installation of a scanner inside the isocentric neutron therapy system; and conversion of a 2-doublet quadrupole telescope (on the neutron therapy beamline) to a 2-triplet telescope. The beam-swinger project has been delayed by very late delivery of the magnet iron to the manufacturer, but is now progressing smoothly. The K=600 spectrometer magnets have now been delivered and are being assembled for field mapping. The x,y-table with its associated mapping equipment is complete, together with the driver software. One of the experimental areas has been dedicated to the production of collimated neutron beams and has been equipped with a bending magnet and beam dump, together with steel collimators fixed at 4 degrees intervals from 0 degrees to 16 degrees. Changes to the target cooling and shielding system for isotope production have led to a request for much smaller beam spot sizes on target, and preparations have been made for rearrangement of the isotope beamline to permit installation of quadrupole triplets on the three beamlines after the switching magnet. A practical system of quadrupoles for matching beam properties to the spectrometer has been designed. 6 figs

  12. High intensity negative proton beams from a SNICS ion source

    International Nuclear Information System (INIS)

    Evans, C.R.; Hollander, M.G.

    1991-01-01

    For the past year we have been involved in a project to develop an intense (> 100μA) negative proton beam from a SNICS (Source of Negative Ions by Cesium Sputtering) ion source. This report will cover how we accomplished and exceeded this goal by more than 40%. Included in these observations will be the following: A description of an effective method for making titanium hydride cathodes. How to overcome the limitations of the titanium hydride cathode. The modification of the SNICS source to improve output; including the installation of the conical ionizer and the gas cathode. A discussion of problems including: poisoning the proton beam with oxygen, alternative gas cathode materials, the clogging of the gas inlet, long burn-in times, and limited cathode life times. Finally, how to optimize source performance when using a gas cathode, and what is the mechanism by which a gas cathode operates; facts, fantasies, or myth

  13. High current beam transport experiments at GSI

    International Nuclear Information System (INIS)

    Klabunde, J.; Schonlein, A.; Spadtke, P.

    1985-01-01

    The status of the high current ion beam transport experiment is reported. 190 keV Ar 1+ ions were injected into six periods of a magnetic quadrupole channel. Since the pulse length is > 0.5 ms partial space charge neutralization occurs. In our experiments, the behavior of unneutralized and partially space charge compensated beams is compared. With an unneutralized beam, emittance growth has been measured for high intensities even in case of the zero-current phase advance sigma 0 0 . This initial emittance growth at high tune depression we attribute to the homogenization effect of the space charge density. An analytical formula based on this assumption describes the emittance growth very well. Furthermore the predicted envelope instabilities for sigma 0 > 90 0 were observed even after 6 periods. In agreement with the theory, unstable beam transport was also experimentally found if a beam with different emittances in the two transverse phase planes was injected into the transport channel. Although the space charge force is reduced for a partially neutralized beam a deterioration of the beam quality was measured in a certain range of beam parameters. Only in the range where an unneutralized beam shows the initial emittance growth, the partial neutralization reduces this effect, otherwise the partially neutralized beam is more unstable

  14. Magnetically scanned proton therapy beams: rationales and techniques

    International Nuclear Information System (INIS)

    Jones, D.T.L.; Schreuder, A.N.

    2000-01-01

    Perhaps the most important advantages of beam scanning systems for proton therapy in comparison with conventional passive beam spreading systems are: (1) Intensity modulation and inverse planning are possible. (2) There is negligible reduction in the range of the beam. (3) Integral dose is reduced as dose conformation to the proximal edge of the lesion is possible. (4) In principle no field-specific modifying devices are required. (5) There is less activation of the surroundings. (6) Scanning systems axe almost infinitely flexible. The main disadvantages include: (1) Scanning systems are more complicated and therefore potentially less reliable and more dangerous. (2) The development of such systems is more demanding in terms of cost, time and manpower. (3) More stable beams are required. (4) Dose and beam position monitoring are more difficult. (5) The problems associated with patient and organ movement axe more severe. There are several techniques which can be used for scanning. For lateral beam spreading, circular scanning (wobbling) or linear scanning can be done. In the latter case the beam can be scanned continuously or in a discrete fashion (spot scanning). Another possibility is to undertake the fastest scan in one dimension (strip scanning) and translate the patient or the scanning magnet in the other dimension. Depth variation is achieved by interposing degraders in the beam (cyclotrons) or by changing the beam energy (synchrotrons). The aim of beam scanning is to deliver a predetermined dose at any point in the body. Special safety precautions must be taken because of the high instantaneous dose rates. The beam position and the dose delivered at each point must be accurately and redundantly determined. (author)

  15. Innovative thin silicon detectors for monitoring of therapeutic proton beams: preliminary beam tests

    Science.gov (United States)

    Vignati, A.; Monaco, V.; Attili, A.; Cartiglia, N.; Donetti, M.; Fadavi Mazinani, M.; Fausti, F.; Ferrero, M.; Giordanengo, S.; Hammad Ali, O.; Mandurrino, M.; Manganaro, L.; Mazza, G.; Sacchi, R.; Sola, V.; Staiano, A.; Cirio, R.; Boscardin, M.; Paternoster, G.; Ficorella, F.

    2017-12-01

    To fully exploit the physics potentials of particle therapy in delivering dose with high accuracy and selectivity, charged particle therapy needs further improvement. To this scope, a multidisciplinary project (MoVeIT) of the Italian National Institute for Nuclear Physics (INFN) aims at translating research in charged particle therapy into clinical outcome. New models in the treatment planning system are being developed and validated, using dedicated devices for beam characterization and monitoring in radiobiological and clinical irradiations. Innovative silicon detectors with internal gain layer (LGAD) represent a promising option, overcoming the limits of currently used ionization chambers. Two devices are being developed: one to directly count individual protons at high rates, exploiting the large signal-to-noise ratio and fast collection time in small thicknesses (1 ns in 50 μm) of LGADs, the second to measure the beam energy with time-of-flight techniques, using LGADs optimized for excellent time resolutions (Ultra Fast Silicon Detectors, UFSDs). The preliminary results of first beam tests with therapeutic beam will be presented and discussed.

  16. Fabrication of Faraday Cup Array for the Measurement of 2-Dimensional Proton Beam Profile

    International Nuclear Information System (INIS)

    Jung, Myunghwan; Kim, Bom Sok; Kim, Kyeryung

    2014-01-01

    It has an advantage of easy-to-use and possible to visually check, immediately; on the other hand, the measurement range is very limited. Another method is using the CCD camera-scintillator device such as p43 phosphor screen or chromox. A variety of faraday cup detectors have been recently introduced. The faraday cup is one of the powerful and popular tools for the measurement of beam current. By using several faraday cups in array geometry, it is possible to observe current distribution. In this study, we developed an external faraday cup array for the measure the beam current and profile at a KOMAC (Korea Multi-purpose Accelerator Complex) beam utilization facility. To measure the beam profile, before fabrication of faraday cup array, we use gafchromic film. By making the faraday cup array we were able to reduce the consumption of Gafchromic film and a more accurate diagnosis of the proton beam is possible. The use of faraday cup array, experiment using the proton beam is more reliable and confident

  17. Proton radiation therapy for retinoblastoma: Comparison of various intraocular tumor locations and beam arrangements

    International Nuclear Information System (INIS)

    Krengli, Marco; Hug, Eugen B.; Adams, Judy A.; Smith, Alfred R.; Tarbell, Nancy J.; Munzenrider, John E.

    2005-01-01

    Purpose: To study the optimization of proton beam arrangements for various intraocular tumor locations; and to correlate isodose distributions with various target and nontarget structures. Methods and materials: We considered posterior-central, nasal, and temporal tumor locations, with straight, intrarotated, or extrarotated eye positions. Doses of 46 cobalt grey equivalent (CGE) to gross tumor volume (GTV) and 40 CGE to clinical target volume (CTV) (2 CGE per fraction) were assumed. Using three-dimensional planning, we compared isodose distributions for lateral, anterolateral oblique, and anteromedial oblique beams and dose-volume histograms of CTVs, GTVs, lens, lacrimal gland, bony orbit, and soft tissues. Results: All beam arrangements fully covered GTVs and CTVs with optimal lens sparing. Only 15% of orbital bone received doses ≥20 CGE with a lateral beam, with 20-26 CGE delivered to two of three growth centers. The anterolateral oblique approach with an intrarotated eye resulted in additional reduction of bony volume and exposure of only one growth center. No appreciable dose was delivered to the contralateral eye, brain tissue, or pituitary gland. Conclusions: Proton therapy achieved homogeneous target coverage with true lens sparing. Doses to orbit structures, including bony growth centers, were minimized with different beam arrangements and eye positions. Proton therapy could reduce the risks of second malignancy and cosmetic and functional sequelae

  18. Proton storage rings

    International Nuclear Information System (INIS)

    Rau, R.R.

    1978-04-01

    A discussion is given of proton storage ring beam dynamic characteristics. Topics considered include: (1) beam energy; (2) beam luminosity; (3) limits on beam current; (4) beam site; (5) crossing angle; (6) beam--beam interaction; (7) longitudinal instability; (8) effects of scattering processes; (9) beam production; and (10) high magnetic fields. Much of the discussion is related to the design parameters of ISABELLE, a 400 x 400 GeV proton---proton intersecting storage accelerator to be built at Brookhaven National Laboratory

  19. Micro computer aided beam transport for the SF cyclotron

    International Nuclear Information System (INIS)

    Honma, Toshihiro; Yamazaki, Tsutomu.

    1984-01-01

    An improvement of the beam transport system for the SF cyclotron is described. The system was designed to handle on-line alignment of the beam extracted from the SF cyclotron onto the optical axis of the transport line. It also enables to measure the beam emittance. The measurement of the emittance parameters is in particular necessary to calculate the beam optics. The calculation has been modified to become easy to handle. With the help of the computer-aided on-line beam profile measurement system, the operation of the beam transport system is very subservient to shorten the beam-tuning time and to improve the beam-transmission efficiency and the quality. (author)

  20. Monte Carlo investigation of the low-dose envelope from scanned proton pencil beams

    International Nuclear Information System (INIS)

    Sawakuchi, Gabriel O; Titt, Uwe; Mirkovic, Dragan; Ciangaru, George; Zhu, X Ronald; Sahoo, Narayan; Gillin, Michael T; Mohan, Radhe

    2010-01-01

    Scanned proton pencil beams carry a low-dose envelope that extends several centimeters from the individual beam's central axis. Thus, the total delivered dose depends on the size of the target volume and the corresponding number and intensity of beams necessary to cover the target volume uniformly. This dependence must be considered in dose calculation algorithms used by treatment planning systems. In this work, we investigated the sources of particles contributing to the low-dose envelope using the Monte Carlo technique. We used a validated model of our institution's scanning beam line to determine the contributions to the low-dose envelope from secondary particles created in a water phantom and particles scattered in beam line components. Our results suggested that, for high-energy beams, secondary particles produced by nuclear interactions in the water phantom are the major contributors to the low-dose envelope. For low-energy beams, the low-dose envelope is dominated by particles undergoing multiple Coulomb scattering in the beam line components and water phantom. Clearly, in the latter situation, the low-dose envelope depends directly on beam line design features. Finally, we investigated the dosimetric consequences of the low-dose envelope. Our results showed that if not modeled properly the low-dose envelope may cause clinically relevant dose disturbance in the target volume. This work suggested that this low-dose envelope is beam line specific for low-energy beams, should be thoroughly experimentally characterized and validated during commissioning of the treatment planning system, and therefore is of great concern for accurate delivery of proton scanning beam doses.