WorldWideScience

Sample records for prom bonae spei

  1. Using the SPEI to Estimate Food Production in East Africa

    Science.gov (United States)

    Husak, G. J.; Hobbins, M.; Verdin, J. P.; Peterson, P.; Funk, C. C.

    2015-12-01

    The Famine Early Warning Systems Network (FEWS NET) monitors critical environmental variables that impact food production in developing countries. Due to a sparse network of observations in the developing world, many of these variables are estimated using remotely sensed data. As scientists develop new techniques to leverage available observations and remotely sensed information there are opportunities to create products that identify the environmental conditions that stress agriculture and reduce food production. FEWS NET pioneered the development of the Climate Hazards Group InfraRed Precipitation with stations (CHIRPS) dataset, to estimate precipitation and monitor growing conditions throughout the world. These data are used to drive land surface models, hydrologic models and basic crop models among others. A new dataset estimating the reference evapotranspiration (ET0) has been developed using inputs from the ERA-Interim GCM. This ET0 dataset stretches back to 1981, allowing for a long-term record, stretching many seasons and drought events. Combining the CHIRPS data to estimate water availability and the ET0 data to estimate evaporative demand, one can estimate the approximate water gap (surplus or deficit) over a specific time period. Normalizing this difference creates the Standardized Precipitation Evapotranspiration Index (SPEI), which presents these gaps in comparison to the historical record for a specific location and accumulation period. In this study we evaluate the SPEI as a tool to estimate crop yields for different regions of Kenya. Identifying the critical time of analysis for the SPEI is the first step in building a relationship between the water gap and food production. Once this critical period is identified, we look at the predictability of food production using the SPEI, and assess the utility of it for monitoring food security, with the goal of incorporating the SPEI in the standard monitoring suite of FEWS NET tools.

  2. Patient reported outcome measures (PROMs)

    DEFF Research Database (Denmark)

    Bech, Per; Austin, Stephen Fitzgerald; Lau, Marianne Engelbrecht

    2018-01-01

    INTRODUCTION: Patient-reported outcome measures (PROMs) for anxiety and depressive disorders are an important aspect of measurement-based care. AIM: The aim of the study was to perform a clinimetric analysis of two PROMs scales in patents with depression and anxiety. METHODS: Patients completed...... recruited from two Danish mental health centers with anxiety or depression. The standardization of the SCL-10 and WHO-5 by T-scores indicated that a T-score of 65 corresponding to being moderately in need of treatment and a T-score of 75 to be severely in need of treatment. The coefficient of alpha...... with anxiety or depression undergoing psychotherapy treatment....

  3. Timescale differences between SC-PDSI and SPEI for drought monitoring in China

    Science.gov (United States)

    Zhao, Haiyan; Gao, Ge; An, Wei; Zou, Xukai; Li, Haitao; Hou, Meiting

    2017-12-01

    The Palmer Drought Severity Index (PDSI) has been widely used to monitor drought. Its characteristics are more suitable for measuring droughts of longer timescales, and this fact has not received much attention. The Standardized Precipitation Evapotranspiration Index (SPEI) can better reflect the climatic water balance, owing to its combination of precipitation and potential evapotranspiration. In this study, we selected monthly average air temperature and precipitation data from 589 meteorological stations of China's National Meteorological Information Center, to compare the effects of applying a self-calibrating PDSI (SC-PDSI) and SPEI to monitor drought events in the station regions, with a special focus on differences of event timescale. The results show the following. 1) Comparative analysis using SC-PDSI and SPEI for drought years and characters of three dry periods from 1961 to 2011 in the Beijing region showed that durations of SC-PDSI-based dry spells were longer than those of 3-month and 6-month SPEIs, but equal to those of 12-month or longer timescale SPEIs. 2) For monitoring evolution of the fall 2009 to spring 2010 Southwest China drought and spring 2000 Huang-Huai drought, 3-month SPEI could better monitor the initiation, aggravation, alleviation and relief of drought in the two regions, whereas the SC-PDSI was insensitive to drought recovery because of its long-term memory of previous climate conditions. 3) Analysis of the relationship between SC-PDSI for different regions and SPEI for different timescales showed that correlation of the two indexes changed with region, and SC-PDSI was maximally correlated with SPEI of 9-19 months in China. Therefore, SC-PDSI is only suitable for monitoring mid- and long-term droughts, owing to the strong lagged autocorrelation such as 0.4786 for 12-month lagged ones in Beijing, whereas SPEI is suitable for both short- and long-term drought-monitoring and should have greater application prospects in China.

  4. PROM and Labour Effects on Urinary Metabolome: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Alessandra Meloni

    2018-01-01

    Full Text Available Since pathologies and complications occurring during pregnancy and/or during labour may cause adverse outcomes for both newborns and mothers, there is a growing interest in metabolomic applications on pregnancy investigation. In fact, metabolomics has proved to be an efficient strategy for the description of several perinatal conditions. In particular, this study focuses on premature rupture of membranes (PROM in pregnancy at term. For this project, urine samples were collected at three different clinical conditions: out of labour before PROM occurrence (Ph1, out of labour with PROM (Ph2, and during labour with PROM (Ph3. GC-MS analysis, followed by univariate and multivariate statistical analysis, was able to discriminate among the different classes, highlighting the metabolites most involved in the discrimination.

  5. PROM and Labour Effects on Urinary Metabolome: A Pilot Study

    Science.gov (United States)

    Meloni, Alessandra; Palmas, Francesco; Mereu, Rossella; Deiana, Sara Francesca; Fais, Maria Francesca; Mussap, Michele; Ragusa, Antonio; Pintus, Roberta; Fanos, Vassilios; Melis, Gian Benedetto

    2018-01-01

    Since pathologies and complications occurring during pregnancy and/or during labour may cause adverse outcomes for both newborns and mothers, there is a growing interest in metabolomic applications on pregnancy investigation. In fact, metabolomics has proved to be an efficient strategy for the description of several perinatal conditions. In particular, this study focuses on premature rupture of membranes (PROM) in pregnancy at term. For this project, urine samples were collected at three different clinical conditions: out of labour before PROM occurrence (Ph1), out of labour with PROM (Ph2), and during labour with PROM (Ph3). GC-MS analysis, followed by univariate and multivariate statistical analysis, was able to discriminate among the different classes, highlighting the metabolites most involved in the discrimination. PMID:29511388

  6. Using the SPEI to Assess Recent Climate Change in the Yarlung Zangbo River Basin, South Tibet

    Directory of Open Access Journals (Sweden)

    Binquan Li

    2015-10-01

    Full Text Available The Yarlung Zangbo River (YZR is the largest river system in the Tibetan Plateau, and its basin is one of the centers of human economic activity in Tibet. Large uncertainties exist in several previous climate change studies in this basin because of limited climate observations. In this paper, we used a meteorological drought index (Standardized Precipitation Evapotranspiration Index, SPEI and a newly-released gridded climate forcing dataset based on high-quality climate station data to re-evaluate climate change in the YZR Basin during the period of 1961–2014. Results showed that precipitation experienced a statistically insignificant increasing trend at a rate of 6.32 mm/10 years, and its annual mean was 512.40 mm. The basin was sensitive to climate change in terms of the air temperature that significantly increased at the rate of 0.32 °C/10 years. This warming rate was obviously larger than that in many other regions. Analysis of SPEI showed that the basin had no obvious statistical trends in the number of dry/wet episodes, but the severity of dry episode aggravated in terms of duration and magnitude. This study provides a reliable analysis of climate change in the YZR Basin, and suggests this large Tibetan river basin is sensitive to climate change.

  7. 19 CFR 10.152 - Bona-fide gifts.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Bona-fide gifts. 10.152 Section 10.152 Customs... and Bona Fide Gifts § 10.152 Bona-fide gifts. Subject to the conditions in § 10.153 of this part, the port director shall pass free of duty and tax any article sent as a bona-fide gift from a person in a...

  8. 19 CFR 145.32 - Bona-fide gifts.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Bona-fide gifts. 145.32 Section 145.32 Customs... (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.32 Bona-fide gifts. The port director... as bona-fide gifts from persons in foreign countries to persons in the United States having an...

  9. Forecasting SPEI and SPI Drought Indices Using the Integrated Artificial Neural Networks

    Directory of Open Access Journals (Sweden)

    Petr Maca

    2016-01-01

    Full Text Available The presented paper compares forecast of drought indices based on two different models of artificial neural networks. The first model is based on feedforward multilayer perceptron, sANN, and the second one is the integrated neural network model, hANN. The analyzed drought indices are the standardized precipitation index (SPI and the standardized precipitation evaporation index (SPEI and were derived for the period of 1948–2002 on two US catchments. The meteorological and hydrological data were obtained from MOPEX experiment. The training of both neural network models was made by the adaptive version of differential evolution, JADE. The comparison of models was based on six model performance measures. The results of drought indices forecast, explained by the values of four model performance indices, show that the integrated neural network model was superior to the feedforward multilayer perceptron with one hidden layer of neurons.

  10. An introduction to patient-reported outcome measures (PROMs) in physiotherapy

    NARCIS (Netherlands)

    Kyte, D.G.; Calvert, M.; Wees, P.J. van der; Hove, R. Ten; Tolan, S.; Hill, J.C.

    2015-01-01

    The use of patient-reported outcome measures (PROMs) is set to rise in physiotherapy. PROMs provide additional 'patient-centred' data which is unique in capturing the patient's own opinion on the impact of their disease or disorder, and its treatment, on their life. Thus, PROMs are increasingly used

  11. 42 CFR 433.54 - Bona fide donations.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Bona fide donations. 433.54 Section 433.54 Public... Financial Participation § 433.54 Bona fide donations. (a) A bona fide donation means a provider-related donation, as defined in § 433.52, made to the State or unit of local government, that has no direct or...

  12. Assessment of the Impact of Climate Change on Drought Characteristics in the Hwanghae Plain, North Korea Using Time Series SPI and SPEI: 1981–2100

    Directory of Open Access Journals (Sweden)

    Sang-Hyun Lee

    2017-08-01

    Full Text Available North Korea is a food-deficit nation in which climate change could have a significant impact on drought. We analyzed drought characteristics in the Hwanghae Plain, North Korea using both the multiple timescales of the standardized precipitation index (SPI and the standardized precipitation evapotranspiration index (SPEI from 1981 to 2100. The probability of non-exceedance for a one-month SPEI below −1.0 was only 1.1% in the spring season of 1995 but increased to 24.4% in 2085. The SPEI for a ten-year return period varied from −0.6 to −0.9 in 1995 and decreased to −1.18 in 2025. The results indicate that severe drought is more likely to occur in future as a result of climate change. The seasonal drought conditions were also significantly influenced by climate change. The largest decrease in the SPEI occurred in late spring and early summer, both of which are important for rice growth. Drought characteristics include severity, duration, and intensity. Therefore, we applied the time series of SPIs and SPEIs to the runs theory and found that the drought intensity identified by one-month SPEIs in 1995 was at a level of 1.21, which reached 1.39 in 2085, implying that climate change will intensify drought in the future.

  13. Amnioinfusion in preterm PROM: effects on amnion and cord histology.

    Science.gov (United States)

    Locatelli, A; Andreani, M; Ghidini, A; Verderio, M; Pizzardi, A; Vergani, P; Salafia, C M

    2008-02-01

    To investigate the effects of transabdominal amnioinfusion (TA) on the histology of amnion (A) and umbilical cord (UC). From a cohort of 56 singleton pregnancies with premature rupture of membranes (PROM) at PROM of 18.7 weeks and at delivery of 26.1 weeks, with a latency of 50 days. Compared with subjects who declined the procedure, TA had a beneficial effect on clinical variables, mediated primarily by a longer latency. TA was not associated with identifiable effects on the histologic features of A or UC. A and UC histology is not significantly affected by exposure to saline solution even for prolonged periods of time.

  14. An introduction to patient-reported outcome measures (PROMs) in physiotherapy.

    Science.gov (United States)

    Kyte, D G; Calvert, M; van der Wees, P J; ten Hove, R; Tolan, S; Hill, J C

    2015-06-01

    The use of patient-reported outcome measures (PROMs) is set to rise in physiotherapy. PROMs provide additional 'patient-centred' data which is unique in capturing the patient's own opinion on the impact of their disease or disorder, and its treatment, on their life. Thus, PROMs are increasingly used by clinicians to guide routine patient care, or for the purposes of audit, and are already firmly embedded in clinical research. This article seeks to summarise the key aspects of PROM use for physiotherapists, both in routine clinical practice and in the research setting, and highlights recent developments in the field. Generic and condition-specific PROMs are defined and examples of commonly used measures are provided. The selection of appropriate PROMs, and their effective use in the clinical and research settings is discussed. Finally, existing barriers to PROM use in practice are identified and recent physiotherapy PROM initiatives, led by the Royal Dutch Society for Physical Therapy are explored. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  15. Creating guidance for the use of patient reported outcome measures (PROMS) in clinical palliatieve care.

    NARCIS (Netherlands)

    Vliet, L.M. van; Harding, R.; Bausewein, C.; Payne, S.; Higginson, I.J.

    2014-01-01

    Introduction: Routine use of Patient Reported Outcome Measures (PROMs) in clinical practice can influence care but is not always achieved. One reason for this seems to be a lack of guidance on how to use PROMs in palliative care practice. This project aimed to provide such guidance. Aim(s) and

  16. A systematic review of patient reported outcome measures (PROMs) used in child and adolescent burn research.

    Science.gov (United States)

    Griffiths, C; Armstrong-James, L; White, P; Rumsey, N; Pleat, J; Harcourt, D

    2015-03-01

    Patient reported outcome measures (PROMs) can identify important information about patient needs and therapeutic progress. The aim of this review was to identify the PROMs that are being used in child and adolescent burn care and to determine the quality of such scales. Computerised and manual bibliographic searches of Medline, Social Sciences Index, Cinahl, Psychinfo, Psycharticles, AMED, and HAPI, were used to identify English-language articles using English-language PROMs from January 2001 to March 2013. The psychometric quality of the PROMs was assessed. 23 studies met the entry criteria and identified 32 different PROMs (31 generic, 1 burns-specific). Overall, the psychometric quality of the PROMs was low; only two generic scales (the Perceived Stigmatisation Questionnaire and the Social Comfort Scale) and only one burns-specific scale (the Children Burn Outcomes Questionnaire for children aged 5-18) had psychometric evidence relevant to this population. The majority of PROMs did not have psychometric evidence for their use with child or adolescent burn patients. To appropriately identify the needs and treatment progress of child and adolescent burn patients, new burns-specific PROMs need to be developed and validated to reflect issues that are of importance to this population. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

  17. The Use Of Standardized Indicators (SPI And SPEI In Predicting Droughts Over The Republic Of Moldova Territory

    Directory of Open Access Journals (Sweden)

    Nedealcov M.

    2015-10-01

    Full Text Available The drought events frequent manifestation over the Republic of Moldova territory, in the context of climate change requires a scientific monitoring adjusted to international researchers. In recent years, internationally, the estimation of this phenomenon occurs through standardized indexes. The most used of these, being the Standardized Precipitation Index (SPI and the Standardized Precipitation Evapotranspiration Index (SPEI. Since there is no a unified definition of drought, the World Meteorological Organization proposes to calculate the indexes, through developed calculation software. Thus, based on multi-annual data (1980-2014 a regional spatio-temporal estimation concerning drought in the Republic of Moldova was performed, thereby realizing the regional investigations framing in the international ones.

  18. Application of validity theory and methodology to patient-reported outcome measures (PROMs): building an argument for validity.

    Science.gov (United States)

    Hawkins, Melanie; Elsworth, Gerald R; Osborne, Richard H

    2018-07-01

    Data from subjective patient-reported outcome measures (PROMs) are now being used in the health sector to make or support decisions about individuals, groups and populations. Contemporary validity theorists define validity not as a statistical property of the test but as the extent to which empirical evidence supports the interpretation of test scores for an intended use. However, validity testing theory and methodology are rarely evident in the PROM validation literature. Application of this theory and methodology would provide structure for comprehensive validation planning to support improved PROM development and sound arguments for the validity of PROM score interpretation and use in each new context. This paper proposes the application of contemporary validity theory and methodology to PROM validity testing. The validity testing principles will be applied to a hypothetical case study with a focus on the interpretation and use of scores from a translated PROM that measures health literacy (the Health Literacy Questionnaire or HLQ). Although robust psychometric properties of a PROM are a pre-condition to its use, a PROM's validity lies in the sound argument that a network of empirical evidence supports the intended interpretation and use of PROM scores for decision making in a particular context. The health sector is yet to apply contemporary theory and methodology to PROM development and validation. The theoretical and methodological processes in this paper are offered as an advancement of the theory and practice of PROM validity testing in the health sector.

  19. Evaluation and demonstration of commercialization potential of CCSI tools within gPROMS advanced simulation platform

    Energy Technology Data Exchange (ETDEWEB)

    Lawal, Adekola [Process Systems Enterprise Inc., Cedar Knolls, NJ (United States); Schmal, Pieter [Process Systems Enterprise Inc., Cedar Knolls, NJ (United States); Ramos, Alfredo [Process Systems Enterprise Inc., Cedar Knolls, NJ (United States); Cano, Alejandro [Process Systems Enterprise Inc., Cedar Knolls, NJ (United States); Bhattacharyya, Debangsu [West Virginia Univ., Morgantown, WV (United States); Mebane, David [West Virginia Univ., Morgantown, WV (United States); Sahinidis, Nikolaos [Carnegie Mellon Univ., Pittsburgh, PA (United States); Chowdhury, Ananya [Process Systems Enterprise Inc., Cedar Knolls, NJ (United States); Liu, Xiaohui [Process Systems Enterprise Inc., Cedar Knolls, NJ (United States); Bellinghausen, Stefan [Process Systems Enterprise Inc., Cedar Knolls, NJ (United States)

    2017-05-29

    PSE, in the first phase of the CCSI commercialization project, set out to identify market opportunities for the CCSI tools combined with existing gPROMS platform capabilities and develop a clear technical plan for the proposed commercialization activities.

  20. An Independent Psychometric Evaluation of the PROMS Measure of Music Perception Skills.

    Science.gov (United States)

    Kunert, Richard; Willems, Roel M; Hagoort, Peter

    2016-01-01

    The Profile of Music Perception Skills (PROMS) is a recently developed measure of perceptual music skills which has been shown to have promising psychometric properties. In this paper we extend the evaluation of its brief version to three kinds of validity using an individual difference approach. The brief PROMS displays good discriminant validity with working memory, given that it does not correlate with backward digit span (r = .04). Moreover, it shows promising criterion validity (association with musical training (r = .45), musicianship status (r = .48), and self-rated musical talent (r = .51)). Finally, its convergent validity, i.e. relation to an unrelated measure of music perception skills, was assessed by correlating the brief PROMS to harmonic closure judgment accuracy. Two independent samples point to good convergent validity of the brief PROMS (r = .36; r = .40). The same association is still significant in one of the samples when including self-reported music skill in a partial correlation (rpartial = .30; rpartial = .17). Overall, the results show that the brief version of the PROMS displays a very good pattern of construct validity. Especially its tuning subtest stands out as a valuable part for music skill evaluations in Western samples. We conclude by briefly discussing the choice faced by music cognition researchers between different musical aptitude measures of which the brief PROMS is a well evaluated example.

  1. The Benjamin-Bona-Mahony equation with dissipative memory

    Czech Academy of Sciences Publication Activity Database

    Dell'Oro, Filippo; Mammeri, Y.; Pata, V.

    2015-01-01

    Roč. 22, č. 4 (2015), s. 899-910 ISSN 1021-9722 Institutional support: RVO:67985840 Keywords : Benjamin-Bona-Mahony equation * dissipative memory * exponential stability * nonlinear contraction semigroup Subject RIV: BA - General Mathematics Impact factor: 0.797, year: 2015 http://link.springer.com/article/10.1007%2Fs00030-014-0308-8

  2. 7 CFR 27.93 - Bona fide spot markets.

    Science.gov (United States)

    2010-01-01

    ... Southwest Markets and the New Mexico counties of Union, Quay, Curry, Roosevelt and Lea. Desert Southwest The..., Hudspeth and El Paso, all New Mexico counties except those included in the West Texas market, all counties... 7 Agriculture 2 2010-01-01 2010-01-01 false Bona fide spot markets. 27.93 Section 27.93...

  3. DMPD: NOD-like receptors (NLRs): bona fide intracellular microbial sensors. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18585455 NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Shaw...tml) (.csml) Show NOD-like receptors (NLRs): bona fide intracellular microbial sensors. PubmedID 18585455 Ti...tle NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Authors

  4. Projected effects of vegetation feedbacks on drought characteristics with SPEI over West Africa using the RegCM-CLM-CN-DV

    Science.gov (United States)

    Jaehyeong, L.; Kim, Y.; Erfanian, A.; Wang, G.; Um, M. J.

    2017-12-01

    This study utilizes the Standardized Precipitation-Evapotranspiration Index (SPEI) to investigate the projected effect of vegetation feedbacks on drought in West Africa using the Regional Climate Model coupled to the NCAR Community Land Model with both the Carbon and Nitrogen module (CN) and Dynamic Vegetation module (DV) activated (RegCM-CLM-CN-DV). The role of vegetation feedbacks is examined based on simulations with and without dynamic vegetation. The four different future climate scenarios from CCSM, GFDL, MIROC and MPI are used as the boundary conditions of RegCM for two historical and future periods, i.e., for 1981 to 2000 and for 2081 to 2100, respectively. Using SPEI, the duration, frequency, severity and spatial extents are quantified over West Africa and analyzed for two regions of the Sahel and the Gulf of Guinea. In this study, we find that the estimated annual SPEIs clearly indicate that the projected future droughts over the Sahel are enhanced and prolonged when DV is activated. The opposite is shown over the Gulf of Guinea in general. AcknowledgementsThis work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2015R1C1A2A01054800), by the Korea Meteorological Administration R&D Program under Grant KMIPA 2015-6180 and by the Yonsei University Future-leading Research Initiative of 2015(2016-22-0061).

  5. Our Energy For The Country Project Started Our Via Bona

    International Nuclear Information System (INIS)

    Anon

    2014-01-01

    Slovenske Elektrarne received the main Via Bona award for its complex and extraordinary approach to responsible business. Non-profit fund Pontis has been granting this award since 1998 to companies voluntarily contributing to the mitigation of negative trends and the improvement of positive business aspects beyond legislative requirements. We won with our Energy for the Country programme. The award was given to Paolo Ruzzini, SE CEO and Chairman of the Board of Directors by Andrej Kiska, the new Slovak President.

  6. On Improving Density Estimators which are not Bona Fide Functions

    OpenAIRE

    Gajek, Leslaw

    1986-01-01

    In order to improve the rate of decrease of the IMSE for nonparametric kernel density estimators with nonrandom bandwidth beyond $O(n^{-4/5})$ all current methods must relax the constraint that the density estimate be a bona fide function, that is, be nonnegative and integrate to one. In this paper we show how to achieve similar improvement without relaxing any of these constraints. The method can also be applied for orthogonal series, adaptive orthogonal series, spline, jackknife, and other ...

  7. PROMs for pain in adult cancer patients: a systematic review of measurement properties.

    Science.gov (United States)

    Abahussin, Asma A; West, Robert M; Wong, David C; Ziegler, Lucy E

    2018-05-17

    Pain is one of the most devastating symptoms for cancer patients. One-third of patients who experience pain do not receive effective treatment. A key barrier to effective pain management is lack of routine measurement and monitoring of pain. Patient-Reported Outcome Measures (PROMs) are recommended for measuring cancer pain. However, evidence to guide the selection of the most appropriate measure to identify and monitor cancer pain is limited. A systematic review of measurement properties of PROMs for pain in cancer patients is needed to identify the best validated measure for adoption to an electronic platform. Systematically review measurement properties of PROMs used for adult cancer patients to measure pain and, as a secondary goal, investigate the evidence of validated mobile health (mHealth) applications used to measure pain (registration number: CRD42017065575). Medline, EMBASE and CINAHL were systematically searched in March 2018 for studies examining measurement properties for PROMs for pain in adult cancer patients. Both of the methodological quality of the studies and their results were appraised using the COSMIN checklist and specific measurement properties criteria respectively. Sixteen studies evaluating eight instruments were included. No studies using a PROM in a mHealth application were identified. The methodological quality of the measurement properties ranged between poor and fair. No instrument showed strong positive evidence for all the evaluated measurement properties. Based on the available evidence, the Brief Pain Inventory-Short Form (BPI-SF) had the strongest evidence to support its selection for the measurement of cancer pain. The BPI-SF was the best performing measure across all proprieties evaluated through COSMIN. Better quality validation studies of PROMs for cancer pain are needed to explore the full range of measurement properties. Utilising mHealth applications for measuring pain for cancer patients is an innovative approach worth

  8. Protocols for Multimedia Systems : 6th International Conference, PROMS 2001 Enschede, The Netherlands, October 17–19, 2001 Proceedings

    NARCIS (Netherlands)

    van Sinderen, Marten J.; Nieuwenhuis, Lambert J.M.

    2001-01-01

    The goal of the PROMS series of conferences and workshops is to contribute to scientific, strategic, and practical cooperation between research institutes and industrial companies in the area of multimedia protocols. This is also the goal of PROMS 2001. The basic theme of this conference continues

  9. Patient reported outcome measures (PROMs) following forward planned field-in field IMRT: Results from the Cambridge Breast IMRT trial

    International Nuclear Information System (INIS)

    Mukesh, Mukesh B.; Qian, Wendi; Wilkinson, Jennifer S.; Dorling, Leila; Barnett, Gillian C.; Moody, Anne M.; Wilson, Charles; Twyman, Nicola; Burnet, Neil G.; Wishart, Gordon C.; Coles, Charlotte E.

    2014-01-01

    Background: The use of intensity-modulated radiotherapy (IMRT) in breast cancer reduces clinician-assessed breast tissue toxicity including fibrosis, telangectasia and sub-optimal cosmesis. Patient reported outcome measures (PROMs) are also important as they provide the patient’s perspective. This longitudinal study reports on (a) the effect of forward planned field-in-field IMRT (∼simple IMRT) on PROMs compared to standard RT at 5 years after RT, (b) factors affecting PROMs at 5 years after RT and (c) the trend of PROMs over 5 years of follow up. Methods: PROMs were assessed at baseline (pre-RT), 6, 24 and 60 months after completion of RT using global health (EORTC QLQ C30) and 4 breast symptom questions (BR23). Also, 4 breast RT-specific questions were included at 6, 24 and 60 months: change in skin appearance, firmness to touch, reduction in breast size and overall change in breast appearance since RT. The benefits of simple IMRT over standard RT at 5 years after RT were assessed using standard t-test for global health and logistic regression analysis for breast symptom questions and breast RT-specific questions. Clinical factors affecting PROMs at 5 years were investigated using a multivariate analysis. A repeated mixed model was applied to explore the trend over time for each of PROMs. Results: (89%) 727/815, 84%, 81% and 61% patients completed questionnaires at baseline, 6, 24 and 60 months respectively. Patients reported worse toxicity for all four BR23 breast symptoms at 6 months, which then improved over time (p < 0.0001). They also reported improvement in skin appearance and breast hardness over time (p < 0.0001), with no significant change for breast shrinkage (p = 0.47) and overall breast appearance (p = 0.13). At 5 years, PROMs assessments did not demonstrate a benefit for simple IMRT over standard radiotherapy. Large breast volume, young age, baseline surgical cosmesis and post-operative infection were the most important variables to affect PROMs

  10. Promõshlennõje zonõ ohvatil "mjortvõi sezon" / Ain Alvela

    Index Scriptorium Estoniae

    Alvela, Ain, 1967-

    2008-01-01

    Arendajad on tehnoparkide rajamise ooterežiimile pannud - ostjaid jaguks, kuid võimalusi napib. Diagramm: Za pjat let stoimost zemli promõshlennogo naznatshenija võrosla v pjat raz; Tabel: Naiboleje dorogaja zemlja - v promparke Lasnamäe. Kommenteerivad Enn Tosso, Nikolai Pitshugov ja Urmas Ahven

  11. An independent psychometric evaluation of the PROMS measure of music perception skills

    NARCIS (Netherlands)

    Kunert, R.; Willems, R.M.; Hagoort, P.

    2016-01-01

    The Profile of Music Perception Skills (PROMS) is a recently developed measure of perceptual music skills which has been shown to have promising psychometric properties. In this paper we extend the evaluation of its brief version to three kinds of validity using an individual difference approach.

  12. 7 CFR 15a.61 - Sex as a bona-fide occupational qualification.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Sex as a bona-fide occupational qualification. 15a.61... RECEIVING OR BENEFITTING FROM FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs and Activities Prohibited § 15a.61 Sex as a bona-fide occupational...

  13. 78 FR 9330 - Revision of Regulations Defining Bona Fide Cotton Spot Markets

    Science.gov (United States)

    2013-02-08

    ... Cotton Spot Markets AGENCY: Agricultural Marketing Service, USDA. ACTION: Proposed rule. SUMMARY: The... bona fide cotton spot markets in order to assure consistency with the revised Cotton Research and Promotion Act. Updated bona fide spot market definitions will allow for published spot quotes to consider...

  14. 7 CFR 27.96 - Quotations in bona fide spot markets.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Quotations in bona fide spot markets. 27.96 Section 27... Differences § 27.96 Quotations in bona fide spot markets. The price or value and differences between the price... determined by the sale of spot cotton in such spot market. Quotations shall be determined and maintained in...

  15. Travelling wave solutions of the generalized Benjamin-Bona-Mahony equation

    International Nuclear Information System (INIS)

    Estevez, P.G.; Kuru, S.; Negro, J.; Nieto, L.M.

    2009-01-01

    A class of particular travelling wave solutions of the generalized Benjamin-Bona-Mahony equation is studied systematically using the factorization technique. Then, the general travelling wave solutions of Benjamin-Bona-Mahony equation, and of its modified version, are also recovered.

  16. Exploring key considerations when determining bona fide inadvertent errors resulting in understatements

    Directory of Open Access Journals (Sweden)

    Chrizanne de Villiers

    2016-03-01

    Full Text Available Chapter 16 of the Tax Administration Act (28 of 2011 (the TA Act deals with understatement penalties. In the event of an ‘understatement’, in terms of Section 222 of the TA Act, a taxpayer must pay an understatement penalty, unless the understatement results from a bona fide inadvertent error. The determining of a bona fide inadvertent error on taxpayers’ returns is a totally new concept in the tax fraternity. It is of utmost importance that this section is applied correctly based on sound evaluation principles and not on professional judgement when determining if the error was indeed the result of a bona fide inadvertent error. This research study focuses on exploring key considerations when determining bona fide inadvertent errors resulting in understatements. The role and importance of tax penalty provisions is explored and the meaning of the different components in the term ‘bona fide inadvertent error’ critically analysed with the purpose to find a possible definition for the term ‘bona fide inadvertent error’. The study also compares the provisions of other tax jurisdictions with regards to errors made resulting in tax understatements in order to find possible guidelines on the application of bona fide inadvertent errors as contained in Section 222 of the TA Act. The findings of the research study revealed that the term ‘bona fide inadvertent error’ contained in Section 222 of the TA Act should be defined urgently and that guidelines must be provided by SARS on the application of the new amendment. SARS should also clarify the application of a bona fide inadvertent error in light of the behaviours contained in Section 223 of the TA Act to avoid any confusion.

  17. Patient-reported outcome measures (PROMs) for assessing perceived listening effort in hearing loss: protocol for a systematic review

    Science.gov (United States)

    Rapport, Frances L; Boisvert, Isabelle; McMahon, Catherine M; Hutchings, Hayley A

    2017-01-01

    Introduction In the UK, it is estimated that a disabling hearing loss (HL) affects 1 in 6 people. HL has functional, economic and social-emotional consequences for affected individuals. Intervention for HL focuses on improving access to the auditory signal using hearing aids or cochlear implants. However, even if sounds are audible and speech is understood, individuals with HL often report increased effort when listening. Listening effort (LE) may be measured using self-reported measures such as patient-reported outcome measures (PROMs). PROMs are validated questionnaires completed by patients to measure their perceptions of their own functional status and well-being. When selecting a PROM for use in research or clinical practice, it is necessary to appraise the evidence of a PROM’s acceptability to patients, validity, responsiveness and reliability. Methods and analysis A systematic review of studies evaluating the measurement properties of PROMs available to measure LE in HL will be undertaken. MEDLINE, EMBASE, CINAHL, PsychINFO and Web of Science will be searched electronically. Reference lists of included studies, key journals and the grey literature will be hand-searched to identify further studies for inclusion. Two reviewers will independently complete title, abstract and full-text screening to determine study eligibility. Data on the characteristics of each study and each PROM will be extracted. Methodological quality of the included studies will be appraised using the COnsensus-based Standards for the selection of health Measurement INstruments, the quality of included PROMs appraised and the credibility of the evidence assessed. A narrative synthesis will summarise extracted data. Ethics and dissemination Ethical permission is not required, as this study uses data from published research. Dissemination will be through publication in peer-reviewed journals, conference presentations and the lead author’s doctoral dissertation. Findings may inform the

  18. The PU-PROM: A patient-reported outcome measure for peptic ulcer disease.

    Science.gov (United States)

    Liu, Na; Lv, Jing; Liu, Jinchun; Zhang, Yanbo

    2017-12-01

    Patient-reported outcome measure (PROM) conceived to enable description of treatment-related effects, from the patient perspective, bring the potential to improve in clinical research, and to provide patients with accurate information. Therefore, the aim of this study was to develop a patient-centred peptic ulcer patient-reported outcome measure (PU-PROM) and evaluate its reliability, validity, differential item functioning (DIF) and feasibility. To develop a conceptual framework and item pool for the PU-PROM, we performed a literature review and consulted other measures created in China and other countries. Beyond that, we interviewed 10 patients with peptic ulcers, and consulted six key experts to ensure that all germane parameters were included. In the first item selection phase, classical test theory and item response theory were used to select and adjust items to shape the preliminary measure completed by 130 patients and 50 controls. In the next phase, the measure was evaluated used the same methods with 492 patients and 124 controls. Finally, we used the same population in the second item reselection to assess the reliability, validity, DIF and feasibility of the final measure. The final peptic ulcer PRO measure comprised four domains (physiology, psychology, society and treatment), with 11 subdomains, and 54 items. The Cronbach's α coefficient of each subdomain for the measure was >0.800. Confirmatory factory analysis indicated that the construct validity fulfilled expectations. Model fit indices, such as RMR, RMSEA, NFI, NNFI, CFI and IFI, showed acceptable fit. The measure showed a good response rate. The peptic ulcer PRO measure had good reliability, validity, DIF and feasibility, and can be used as a clinical research evaluation instrument with patients with peptic ulcers to assess their condition focus on treatment. This measure may also be applied in other health areas, especially in clinical trials of new drugs, and may be helpful in clinical

  19. Analysis of Current and Future SPEI Droughts in the La Plata Basin Based on Results from the Regional Eta Climate Model

    Directory of Open Access Journals (Sweden)

    Alvaro Sordo-Ward

    2017-11-01

    Full Text Available We identified and analysed droughts in the La Plata Basin (divided into seven sub-basins for the current period (1961–2005 and estimated their expected evolution under future climate projections for the periods 2011–2040, 2041–2070, and 2071–2099. Future climate projections were analysed from results of the Eta Regional Climate Model (grid resolution of approximately 10 km forced by the global climate model HadGEM2-ES over the La Plata basin, and considering a RCP4.5 emission scenario. Within each sub-basin, we particularly focused our drought analyses on croplands and grasslands, due to their economic relevance. The three-month Standardized Precipitation Evapotranspiration Index (SPEI3 was used for drought identification and characterization. Droughts were evaluated in terms of time (percentage of time from the total length of each climate scenario, space (percentage of total area, and severity (SPEI3 values of cells characterized by cropland and grassland for each sub-basin and climate scenario. Drought-severity–area–frequency curves were developed to quantitatively relate the frequency distribution of drought occurrence to drought severity and area. For the period 2011–2040, droughts dominate the northern sub-basins, whereas alternating wet and short dry periods dominate the southern sub-basins. Wet climate spread from south to north within the La Plata Basin as more distant future scenarios were analysed, due to both a greater number of wet periods and fewer droughts. The area of each sub-basin affected by drought in all climate scenarios was highly varied temporally and spatially. The likelihood of the occurrence of droughts differed significantly between the studied cover types in the Lower Paraguay sub-basin, being higher for cropland than for grassland. Mainly in the Upper Paraguay and in the Upper Paraná basins the climate projections for all scenarios showed an increase of moderate and severe droughts over large regions

  20. An intronic deletion in the PROM1 gene leads to autosomal recessive cone-rod dystrophy.

    Science.gov (United States)

    Eidinger, Osnat; Leibu, Rina; Newman, Hadas; Rizel, Leah; Perlman, Ido; Ben-Yosef, Tamar

    2015-01-01

    To investigate the genetic basis for autosomal recessive cone-rod dystrophy (CRD) in a consanguineous Israeli Jewish family. Patients underwent a detailed ophthalmic evaluation, including eye examination, visual field testing, optical coherence tomography (OCT), and electrophysiological tests, electroretinography (ERG) and visual evoked potential (VEP). Genome-wide homozygosity mapping using a single nucleotide polymorphism (SNP) array was performed to identify homozygous regions shared among two of the affected individuals. Mutation screening of the underlying gene was performed with direct sequencing. In silico and in vitro analyses were used to predict the effect of the identified mutation on splicing. The affected family members are three siblings who have various degrees of progressive visual deterioration, glare, color vision abnormalities, and night vision difficulties. Visual field tests revealed central scotomas of different extension. Cone and rod ERG responses were reduced, with cones more severely affected. Homozygosity mapping revealed several homozygous intervals shared among two of the affected individuals. One included the PROM1 gene. Sequence analysis of the 26 coding exons of PROM1 in one affected individual revealed no mutations in the coding sequence or in intronic splice sites. However, in intron 21, proximate to the intron-exon junction, we observed a homozygous 10 bp deletion between positions -26 and -17 (c.2281-26_-17del). The deletion was linked to a known SNP, c.2281-6C>G. The deletion cosegregated with the disease in the family, and was not detected in public databases or in 101 ethnically-matched control individuals. In silico analysis predicted that this deletion would lead to altered intron 21 splicing. Bioinformatic analysis predicted that a recognition site for the SRSF2 splicing factor is located within the deleted sequence. The in vitro splicing assay demonstrated that c.2281-26_-17del leads to complete exon 22 skipping. A novel

  1. Generating Bona Fide Mammalian Prions with Internal Deletions.

    Science.gov (United States)

    Munoz-Montesino, Carola; Sizun, Christina; Moudjou, Mohammed; Herzog, Laetitia; Reine, Fabienne; Chapuis, Jérôme; Ciric, Danica; Igel-Egalon, Angelique; Laude, Hubert; Béringue, Vincent; Rezaei, Human; Dron, Michel

    2016-08-01

    Mammalian prions are PrP proteins with altered structures causing transmissible fatal neurodegenerative diseases. They are self-perpetuating through formation of beta-sheet-rich assemblies that seed conformational change of cellular PrP. Pathological PrP usually forms an insoluble protease-resistant core exhibiting beta-sheet structures but no more alpha-helical content, loosing the three alpha-helices contained in the correctly folded PrP. The lack of a high-resolution prion structure makes it difficult to understand the dynamics of conversion and to identify elements of the protein involved in this process. To determine whether completeness of residues within the protease-resistant domain is required for prions, we performed serial deletions in the helix H2 C terminus of ovine PrP, since this region has previously shown some tolerance to sequence changes without preventing prion replication. Deletions of either four or five residues essentially preserved the overall PrP structure and mutant PrP expressed in RK13 cells were efficiently converted into bona fide prions upon challenge by three different prion strains. Remarkably, deletions in PrP facilitated the replication of two strains that otherwise do not replicate in this cellular context. Prions with internal deletion were self-propagating and de novo infectious for naive homologous and wild-type PrP-expressing cells. Moreover, they caused transmissible spongiform encephalopathies in mice, with similar biochemical signatures and neuropathologies other than the original strains. Prion convertibility and transfer of strain-specific information are thus preserved despite shortening of an alpha-helix in PrP and removal of residues within prions. These findings provide new insights into sequence/structure/infectivity relationship for prions. Prions are misfolded PrP proteins that convert the normal protein into a replicate of their own abnormal form. They are responsible for invariably fatal neurodegenerative

  2. Examining the extreme 2017 spring drought event in South Korea using a suite of drought indices (SPI, SC-PDSI, SPEI, EDI)

    Science.gov (United States)

    Nam, W. H.; Hayes, M. J.; Svoboda, M. D.; Fuchs, B.; Tadesse, T.; Wilhite, D. A.; Hong, E. M.; Kim, T.

    2017-12-01

    South Korea has experienced extreme droughts in 1994-1995, 2000-2001, 2012, 2015, and 2016-2017. The 2017 spring drought (with especially low winter precipitation recorded in winter 2016) affected a large portion of central and western South Korea, and was one of the most severe droughts in the region since the 2000-2001 drought. The spring drought of 2017 was characterized by exceptionally low precipitation with total precipitation from January to June being 50% lower than the mean normal precipitation record (1981-2010) over most of western South Korea. It was the climatologically driest spring over the 1961-2016 record period. Effective drought monitoring and management depends on which drought indices are selected because each drought index has different drought criteria or levels of drought severity, associated with drought responses. In this study, for the quantitative analysis of the spring 2017 drought event in South Korea, four widely-used drought indices, including the Standardized Precipitation Index (SPI), the Standardized Precipitation Evapotranspiration Index (SPEI), the Self-Calibrated Palmer Drought Severity Index (SC-PDSI), and the Effective Drought Index (EDI) are compared with observed drought damaged areas in the context of agricultural drought impacts. The South Korean government (Ministry of Agriculture, Food and Rural Affairs (MAFRA) and Korea Rural Community Corporation (KRC)) has been operating a government-level drought monitoring system since 2016. Results from this study can be used to improve the drought monitoring applications, as well as drought planning and preparedness in South Korea.

  3. Is it too early to move to full electronic PROM data collection?: A randomized controlled trial comparing PROM's after hallux valgus captured by e-mail, traditional mail and telephone.

    Science.gov (United States)

    Palmen, Leonieke N; Schrier, Joost C M; Scholten, Ruben; Jansen, Justus H W; Koëter, Sander

    2016-03-01

    Patient reported outcome measures (PROM's) after hallux valgus surgery are used to rate the effectiveness as perceived by the patient. The interpretability of these PROM's is highly dependent on participation rate. Data capture method may be an important factor contributing to the response rate. We investigated the effect on response rate of traditional paper mail, telephone and e-mail PROM's after hallux valgus surgery. All consecutive patients operated between January and September 2013, were identified. Included patients were randomized by envelope in three groups: traditional pen and paper mail, e-mail and telephone. They were asked to fill in a FFI and EQ-5D. Two weeks later non-responders were sent a reminder. Of the 73 included patients, 25 were approached by mail, 24 by e-mail and 24 patients by telephone. The response rate on traditional mail was highest (88%), while response on e-mail was lowest (33%). Response rate on telephone was also high (79%). Response rate on traditional mail and telephone was significantly higher (pmail. Though electronic data collection has enormous potential, this study shows that e-mail yields unacceptable low response rates. It is too early to replace traditional pen-and-paper PROM's by electronic questionnaires. Copyright © 2015 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.

  4. Proceedings of Patient Reported Outcome Measure’s (PROMs) Conference Oxford 2017: Advances in Patient Reported Outcomes Research

    NARCIS (Netherlands)

    Velikova, Galina; Valderas, Jose M.; Potter, Caroline; Batchelder, Laurie; A’Court, Christine; Baker, Matthew; Bostock, Jennifer; Coulter, Angela; Fitzpatrick, Ray; Forder, Julien; Fox, Diane; Geneen, Louise; Gibbons, Elizabeth; Jenkinson, Crispin; Jones, Karen; Kelly, Laura; Peters, Michele; Mulhern, Brendan; Labeit, Alexander; Rowen, Donna; Meadows, Keith; Elliott, Jackie; Brazier, John E.; Knowles, Emma; Keetharuth, Anju; Brazier, John E.; Connell, Janice; Carlton, Jill; Buck, Lizzie Taylor; Ricketts, Thomas; Barkham, Michael; Goswami, Pushpendra; Salek, Sam; Ionova, Tatyana; Oliva, Esther; Fielding, Adele K.; Karakantza, Marina; Al-Ismail, Saad; Collins, Graham P.; McConnell, Stewart; Langton, Catherine; Jennings, Daniel M.; Else, Roger; Kell, Jonathan; Ward, Helen; Day, Sophie; Lumley, Elizabeth; Phillips, Patrick; Duncan, Rosie; Buckley-Woods, Helen; Aber, Ahmed; Jones, Gerogina; Michaels, Jonathan; Porter, Ian; Gangannagaripalli, Jaheeda; Davey, Antoinette; Ricci-Cabello, Ignacio; Haywood, Kirstie; Hansen, Stine Thestrup; Valderas, Jose; Roberts, Deb; Gumber, Anil; Podmore, Bélène; Hutchings, Andrew; van der Meulen, Jan; Aggarwal, Ajay; Konan, Sujith; Price, Andrew; Jackson, William; Bottomley, Nick; Philiips, Michael; Knightley-Day, Toby; Beard, David; Gibbons, Elizabeth; Fitzpatrick, Ray; Greenhalgh, Joanne; Gooding, Kate; Gibbons, Elizabeth; Valderas, Chema; Wright, Judy; Dalkin, Sonia; Meads, David; Black, Nick; Fawkes, Carol; Froud, Robert; Carnes, Dawn; Price, Andrew; Cook, Jonathan; Dakin, Helen; Smith, James; Kang, Sujin; Beard, David; Griffiths, Catrin; Guest, Ella; Harcourt, Diana; Murphy, Mairead; Hollinghurst, Sandra; Salisbury, Chris; Carlton, Jill; Elliott, Jackie; Rowen, Donna; Gao, Anqi; Price, Andrew; Beard, David; Lemanska, Agnieszka; Chen, Tao; Dearnaley, David P.; Jena, Rajesh; Sydes, Matthew; Faithfull, Sara; Ades, A. E.; Kounali, Daphne; Lu, Guobing; Rombach, Ines; Gray, Alastair; Jenkinson, Crispin; Rivero-Arias, Oliver; Holch, Patricia; Holmes, Marie; Rodgers, Zoe; Dickinson, Sarah; Clayton, Beverly; Davidson, Susan; Routledge, Jacqui; Glennon, Julia; Henry, Ann M.; Franks, Kevin; Velikova, Galina; Maguire, Roma; McCann, Lisa; Young, Teresa; Armes, Jo; Harris, Jenny; Miaskowski, Christine; Kotronoulas, Grigorios; Miller, Morven; Ream, Emma; Patiraki, Elizabeth; Geiger, Alexander; Berg, Geir V.; Flowerday, Adrian; Donnan, Peter; McCrone, Paul; Apostolidis, Kathi; Fox, Patricia; Furlong, Eileen; Kearney, Nora; Gibbons, Chris; Fischer, Felix; Gibbons, Chris; Coste, Joel; Martinez, Jose Valderas; Rose, Matthias; Leplege, Alain; Shingler, Sarah; Aldhouse, Natalie; Al-Zubeidi, Tamara; Trigg, Andrew; Kitchen, Helen; Davey, Antoinette; Porter, Ian; Green, Colin; Valderas, Jose M.; Coast, Joanna; Smith, Sarah; Hendriks, Jolijn; Black, Nick; Shah, Koonal; Rivero-Arias, Oliver; Ramos-Goni, Juan-Manuel; Kreimeier, Simone; Herdman, Mike; Devlin, Nancy; Finch, Aureliano Paolo; Brazier, John E.; Mukuria, Clara; Zamora, Bernarda; Parkin, David; Feng, Yan; Bateman, Andrew; Herdman, Mike; Devlin, Nancy; Patton, Thomas; Gutacker, Nils; Shah, Koonal

    2017-01-01

    The proceedings contain 36 papers. The topics discussed include: using patient reported outcome measures (PROMs) in cancer care; validation of the long-term conditions questionnaire (LTCQ) in a diverse sample of health and social care users in England; the national institutes of health

  5. Fiat or bona fide boundary--a matter of granular perspective.

    Directory of Open Access Journals (Sweden)

    Lars Vogt

    Full Text Available Distinguishing bona fide (i.e. natural and fiat (i.e. artificial physical boundaries plays a key role for distinguishing natural from artificial material entities and is thus relevant to any scientific formal foundational top-level ontology, as for instance the Basic Formal Ontology (BFO. In BFO, the distinction is essential for demarcating two foundational categories of material entity: object and fiat object part. The commonly used basis for demarcating bona fide from fiat boundary refers to two criteria: (i intrinsic qualities of the boundary bearers (i.e. spatial/physical discontinuity, qualitative heterogeneity and (ii mind-independent existence of the boundary. The resulting distinction of bona fide and fiat boundaries is considered to be categorial and exhaustive.By Referring to various examples from biology, we demonstrate that the hitherto used distinction of boundaries is not categorial: (i spatial/physical discontinuity is a matter of scale and the differentiation of bona fide and fiat boundaries is thus granularity-dependent, and (ii this differentiation is not absolute, but comes in degrees. By reducing the demarcation criteria to mind-independence and by also considering dispositions and historical relations of the bearers of boundaries, instead of only considering their spatio-structural properties, we demonstrate with various examples that spatio-structurally fiat boundaries can nevertheless be mind-independent and in this sense bona fide.We argue that the ontological status of a given boundary is perspective-dependent and that the strictly spatio-structural demarcation criteria follow a static perspective that is ignorant of causality and the dynamics of reality. Based on a distinction of several ontologically independent perspectives, we suggest different types of boundaries and corresponding material entities, including boundaries based on function (locomotion, physiology, ecology, development, reproduction and common history

  6. Enhancing rigour in the validation of patient reported outcome measures (PROMs: bridging linguistic and psychometric testing

    Directory of Open Access Journals (Sweden)

    Roberts Gwerfyl

    2012-06-01

    Full Text Available Abstract Background A strong consensus exists for a systematic approach to linguistic validation of patient reported outcome measures (PROMs and discrete methods for assessing their psychometric properties. Despite the need for robust evidence of the appropriateness of measures, transition from linguistic to psychometric validation is poorly documented or evidenced. This paper demonstrates the importance of linking linguistic and psychometric testing through a purposeful stage which bridges the gap between translation and large-scale validation. Findings Evidence is drawn from a study to develop a Welsh language version of the Beck Depression Inventory-II (BDI-II and investigate its psychometric properties. The BDI-II was translated into Welsh then administered to Welsh-speaking university students (n = 115 and patients with depression (n = 37 concurrent with the English BDI-II, and alongside other established depression and quality of life measures. A Welsh version of the BDI-II was produced that, on administration, showed conceptual equivalence with the original measure; high internal consistency reliability (Cronbach’s alpha = 0.90; 0.96; item homogeneity; adequate correlation with the English BDI-II (r = 0.96; 0.94 and additional measures; and a two-factor structure with one overriding dimension. Nevertheless, in the student sample, the Welsh version showed a significantly lower overall mean than the English (p = 0.002; and significant differences in six mean item scores. This prompted a review and refinement of the translated measure. Conclusions Exploring potential sources of bias in translated measures represents a critical step in the translation-validation process, which until now has been largely underutilised. This paper offers important findings that inform advanced methods of cross-cultural validation of PROMs.

  7. 40 CFR 5.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 5.550 Sex as a...

  8. 24 CFR 3.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Sex as a bona fide occupational... and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education...

  9. 45 CFR 86.61 - Sex as a bona-fide occupational qualification.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Sex as a bona-fide occupational qualification. 86... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 86.61 Sex as a...

  10. 10 CFR 5.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Sex as a bona fide occupational qualification. 5.550 Section 5.550 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in...

  11. 6 CFR 17.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Sex as a bona fide occupational qualification... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 17.550 Sex as a...

  12. 17 CFR 240.16b-5 - Bona fide gifts and inheritance.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Bona fide gifts and inheritance. 240.16b-5 Section 240.16b-5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... gifts and inheritance. Both the acquisition and the disposition of equity securities shall be exempt...

  13. Law and culture: a theory of comparative variation in bona fide purchase rules

    NARCIS (Netherlands)

    Dari-Mattiacci, G.; Guerriero, C.

    2015-01-01

    A key question in comparative law is why different legal systems provide different legal solutions for the same problem. To answer this question, we use novel comparative evidence on how the conflict between the dispossessed original owner and the bona fide purchaser of a stolen good is resolved in

  14. 29 CFR 516.3 - Bona fide executive, administrative, and professional employees (including academic...

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Bona fide executive, administrative, and professional... outside sales employees employed pursuant to section 13(a)(1) of the Act. 516.3 Section 516.3 Labor... professional employees (including academic administrative personnel and teachers in elementary or secondary...

  15. 15 CFR 8a.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 8a.550 Sex as a...

  16. 38 CFR 23.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Sex as a bona fide... VETERANS AFFAIRS (CONTINUED) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education...

  17. 29 CFR 1625.12 - Exemption for bona fide executive or high policymaking employees.

    Science.gov (United States)

    2010-07-01

    ... corporations [or other business organizations] are usually located at corporate or regional headquarters. With respect to employees whose duties are associated with corporate headquarters operations, such as finance..., would be covered by the term “bona fide executive.” Individuals at higher levels in the corporate...

  18. Oportere ex fide bona. Una construcción decisiva de la jurisprudencia romana

    Directory of Open Access Journals (Sweden)

    Javier Humberto Facco

    2013-07-01

    Full Text Available Verificada la secularización de la antigua fides, asistimos al surgimiento de una construcción cuya valencia técnica parece concretarse en el específico ámbito del proceso. La fides resulta adjetivada con el calificativo de bona. A partir de entonces el sintagma bona fides significará una característica procesal, una cualidad de ciertas acciones que en la intentio de su fórmula se estructuraban en base al oportere ex fide bona. El núcleo de estas acciones estaba representado por los contratos sinalagmáticos, cuya fuerza obligatoria se fundaba en el consentimiento y pertenecían a la órbita del comercio internacional (ius gentium. Con todo, al margen de su aplicación pretoriana, la cláusula quidquid dare facere oportet ex fide bona fue una elaboración eminentemente jurisprudencial, producto del ingenio de los juristas romanos. Fueron ellos quienes idearon buena parte de las soluciones sobre cuestiones ligadas a la eficacia de los contratos consensuales que todavía hoy se consideran emanaciones de la buena fe-lealtad. Recuperar la trascendencia del rol de los juristas en la tarea de hacer que el derecho sea adherente a la realidad constituye la principal invitación que nace de este escrito.

  19. 45 CFR 2555.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Sex as a bona fide occupational qualification. 2555.550 Section 2555.550 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION... to such action is essential to successful operation of the employment function concerned. A recipient...

  20. 45 CFR 618.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Sex as a bona fide occupational qualification. 618.550 Section 618.550 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... successful operation of the employment function concerned. A recipient shall not take action pursuant to this...

  1. 49 CFR 25.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Sex as a bona fide occupational qualification. 25... BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 25.550 Sex as a...

  2. 29 CFR 36.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Sex as a bona fide occupational qualification. 36.550 Section 36.550 Labor Office of the Secretary of Labor NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in...

  3. 28 CFR 54.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Sex as a bona fide occupational... ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 54.550 Sex as a...

  4. 34 CFR 106.61 - Sex as a bona-fide occupational qualification.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Sex as a bona-fide occupational qualification. 106.61..., DEPARTMENT OF EDUCATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or...

  5. 44 CFR 19.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Sex as a bona fide... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in...

  6. 31 CFR 28.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 28.550 Sex as a...

  7. 43 CFR 41.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Sex as a bona fide occupational... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 41.550 Sex as a...

  8. A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM.

    Science.gov (United States)

    Lee, JoonHo; Romero, Roberto; Kim, Sun Min; Chaemsaithong, Piya; Park, Chan-Wook; Park, Joong Shin; Jun, Jong Kwan; Yoon, Bo Hyun

    2016-03-01

    Antibiotic administration is a standard practice in preterm premature rupture of membranes (PROM). Specific anti-microbial agents often include ampicillin and/or erythromycin. Anaerobes and genital mycoplasmas are frequently involved in preterm PROM, but are not adequately covered by antibiotics routinely used in clinical practice. Our objective was to compare outcomes of PROM treated with standard antibiotic administration versus a new combination more effective against these bacteria. A retrospective study compared perinatal outcomes in 314 patients with PROM 23 ng/mL). (1) Patients treated with regimen 2 had a longer median antibiotic-to-delivery interval than those with regimen 1 [median (interquartile range) 23 d (10-51 d) versus 12 d (5-52 d), p acute histologic chorioamnionitis (50.5% versus 66.7%, p hemorrhage (IVH) and cerebral palsy (CP) were significantly lower in patients allocated to regimen 2 than regimen 1 (IVH: 2.1% versus 19.0%, p acute histologic chorioamnionitis/funisitis, and improved neonatal outcomes in patients with preterm PROM. These findings suggest that the combination of anti-microbial agents (ceftriaxone, clarithromycin, and metronidazole) may improve perinatal outcome in preterm PROM.

  9. Soil as a Sustainable Resource for the Bioeconomy - BonaRes

    Science.gov (United States)

    Wollschläger, Ute; Amelung, Wulf; Brüggemann, Nicolas; Brunotte, Joachim; Gebbers, Robin; Grosch, Rita; Heinrich, Uwe; Helming, Katharina; Kiese, Ralf; Leinweber, Peter; Reinhold-Hurek, Barbara; Veldkamp, Edzo; Vogel, Hans-Jörg; Winkelmann, Traud

    2017-04-01

    Fertile soils are a fundamental resource for the production of biomass and provision of food and energy. A growing world population and latest climate targets lead to an increasing demand for bio-based products which require preserving and - ideally - improving the long-term productivity of soils as a bio-economic resource. At the same time, other soil functions and ecosystem services need to be maintained: filter for clean water, carbon sequestration, provision and recycling of nutrients, and habitat for biological activity. All these soil functions result from the interaction of a multitude of physical, chemical and biological processes which are insufficiently understood. In addition, we lack understanding about the interplay between the socio-economic system and the soil system and how soil functions benefit human wellbeing, including SDGs. However, a solid and integrated assessment of soil quality requires the consideration of the ensemble of soil functions and its relation to soil management. To make soil management sustainable, we need to establish a scientific knowledge base of complex soil system processes that allows for developing models and tools to quantitatively predict the impact of a multitude of management measures on soil functions. This will finally allow for the provision of options for a site-specific, sustainable soil management. To face this challenge, the German Federal Ministry of Education and Research (BMBF) recently launched the funding program "Soil as a Sustainable Resource for the Bioeconomy - BonaRes". In a joint effort, ten collaborative projects and the coordinating BonaRes Centre are engaged to close existing knowledge gaps for a profound and systemic assessment and understanding of soil functions and their sensitivity to soil management. In BonaRes, the complete process chain of sustainable soil use in the context of a sustainable bio-economy is being addressed: from understanding of soil processes using state-of the art and

  10. Pengaruh Sosial Demografi terhadap Produktivitas Tenaga Kerja Perempuan Pengrajin Lontar di Desa Bona, Gianyar

    OpenAIRE

    Andari, Ni Putu Uti; Aswitari, Luh Putu

    2012-01-01

    Bali has many center of home industry. The development of home industry is expected to increase local entrepreneurs income and salary of employee. In palm leaf handicrafts, activities done by women. This study aims to determine the factors that impacted to women labour productivity. This research was conducted in the Bona Village Gianyar Regency. The number of sample is 93 which taken purposively. This study uses multiple linear regression analysis. Results showed that the factors that affect...

  11. Comparing bona fide psychotherapies of depression in adults with two meta-analytical approaches.

    Directory of Open Access Journals (Sweden)

    Sarah R Braun

    Full Text Available OBJECTIVE: Despite numerous investigations, the question whether all bona fide treatments of depression are equally efficacious in adults has not been sufficiently answered. METHOD: We applied two different meta-analytical techniques (conventional meta-analysis and mixed treatment comparisons. Overall, 53 studies with 3,965 patients, which directly compared two or more bona fide psychotherapies in a randomized trial, were included. Meta-analyses were conducted regarding five different types of outcome measures. Additionally, the influence of possible moderators was examined. RESULTS: Direct comparisons of cognitive behavior therapy, behavior activation therapy, psychodynamic therapy, interpersonal therapy, and supportive therapies versus all other respective treatments indicated that at the end of treatment all treatments but supportive therapies were equally efficacious whereas there was some evidence that supportive therapies were somewhat less efficacious than all other treatments according to patient self-ratings and clinical significance. At follow-up no significant differences were present. Age, gender, comorbid mental disorders, and length of therapy session were found to moderate efficacy. Cognitive behavior therapy was superior in studies where therapy sessions lasted 90 minutes or longer, behavior activation therapy was more efficacious when therapy sessions lasted less than 90 minutes. Mixed treatment comparisons indicated no statistically significant differences in treatment efficacy but some interesting trends. CONCLUSIONS: This study suggests that there might be differential effects of bona fide psychotherapies which should be examined in detail.

  12. The broad-host-range plasmid pSFA231 isolated from petroleum-contaminated sediment represents a new member of the PromA plasmid family.

    Science.gov (United States)

    Li, Xiaobin; Top, Eva M; Wang, Yafei; Brown, Celeste J; Yao, Fei; Yang, Shan; Jiang, Yong; Li, Hui

    2014-01-01

    A self-transmissible broad-host-range (BHR) plasmid pSFA231 was isolated from petroleum-contaminated sediment in Shen-fu wastewater irrigation zone, China, using the triparental mating exogenous plasmid capture method. Based on its complete sequence the plasmid has a size of 41.5 kb and codes for 50 putative open reading frames (orfs), 29 of which represent genes involved in replication, partitioning and transfer functions of the plasmid. Phylogenetic analysis grouped pSFA231 into the newly defined PromA plasmid family, which currently includes five members. Further comparative genomic analysis shows that pSFA231 shares the common backbone regions with the other PromA plasmids, i.e., genes involved in replication, maintenance and control, and conjugative transfer. Nevertheless, phylogenetic divergence was found in specific gene products. We propose to divide the PromA group into two subgroups, PromA-α (pMRAD02, pSB102) and PromA-β (pMOL98, pIPO2T, pSFA231, pTer331), based on the splits network analysis of the RepA protein. Interestingly, a cluster of hypothetical orfs located between parA and traA of pSFA231 shows high similarity with the corresponding regions on pMOL98, pIPO2T, and pTer331, suggesting these hypothetical orfs may represent "essential" plasmid backbone genes for the PromA-β subgroup. Alternatively, they may also be accessory genes that were first acquired and then stayed as the plasmid diverged. Our study increases the available collection of complete genome sequences of BHR plasmids, and since pSFA231 is the only characterized PromA plasmid from China, our findings also enhance our understanding of the genetic diversity of this plasmid group in different parts of the world.

  13. The broad-host-range plasmid pSFA231 isolated from petroleum-contaminated sediment represents a new member of the PromA plasmid family

    Directory of Open Access Journals (Sweden)

    Xiaobin eLi

    2015-01-01

    Full Text Available A self-transmissible broad-host-range (BHR plasmid pSFA231 was isolated from petroleum-contaminated sediment in Shen-fu wastewater irrigation zone, China, using the triparental mating exogenous plasmid capture method. Based on its complete sequence the plasmid has a size of 41.5 kb and codes for 50 putative open reading frames (orfs, 28 of which represent genes involved in replication, partitioning and transfer functions of the plasmid. Phylogenetic analysis grouped pSFA231 into the newly defined PromA plasmid family, which currently includes five members. Further comparative genomic analysis shows that pSFA231 shares the common backbone regions with the other PromA plasmids, i.e., genes involved in replication, maintenance and control, and conjugative transfer. Nevertheless, phylogenetic divergence was found in specific gene products. We propose to divide the PromA group into two subgroups, PromA-α (pMRAD02, pSB102 and PromA-β (pMOL98, pIPO2T, pSFA231, pTer331, based on the splits network analysis of the RepA protein. Interestingly, a cluster of hypothetical orfs located between parA and traA of pSFA231 shows high similarity with the corresponding regions on pMOL98, pIPO2T and pTer331, suggesting these hypothetical orfs may represent ‘‘essential’’ plasmid backbone genes for the PromA-β subgroup. Alternatively, they may also be accessory genes that were first acquired and then stayed as the plasmid diverged. Our study increases the available collection of complete genome sequences of BHR plasmids, and since pSFA231 is the only characterized PromA plasmid from China, our findings also enhance our understanding of the genetic diversity of this plasmid group in different parts of the world.

  14. LABOUR TERMINATION AND PERINATAL OUTCOME IN PREGNANT WOMEN WITH PLACENTA ABRUPTION WITH PPROM AND PROM

    Directory of Open Access Journals (Sweden)

    Ranko Kutlesic

    2007-10-01

    Full Text Available Placenta abruption is an obstetric accident which endangers life and health of both mother and embryo. It is one of the most serious obstetric complications, whose incidence ranges from 4.9-12.9 per 1,000 labours, and according to frequency, it represents the second cause of perinatal death. Retrospective analysis included the interval from 1996 to 2005. Total number of labours was analyzed and it was 32358. In addition, the number of labours complicated by placenta abruption was analyzed, and it was 119 or 0.37%. It analyzed the incidence of placenta abruption according to age of pregnancy and the integrity of embryonic membranes. It is established that there is no statistically significant difference in the incidence of placenta abruption appearing in pregnant women, with and without the disruption of embryonic membranes. The age of pregnant women was also analyzed, and it was found out that the pregnant women with placenta abruption and PPROM were 5 years older than those with placenta abruption without PPROM, and that this difference was very significant. Disruption duration was analyzed as well as the time from the first uterus bleeding to labour. The difference between PPROM and PROM duration was statistically significant, as well as the difference in duration between spontaneous and artificial rupture of embryonic membranes. The way of labour termination was analyzed in pregnant women with verified placenta abruption. In 80% of pregnant women, the labour was terminated by Caesarian section, and only 20% by vaginal labour. Also, the perinatal outcome was analyzed, according to Apgar score in the first and fifth minute. Apgar score showed that out of the total number of abruptions, 7 neonatuses was born dead (11.66%, 13 (21.66% was born in good condition (Apgar score>7, 26 (43.33% was marked with 4-7, while 14 (23.33% was in hard asphyxia (Apgar score 1-5.

  15. Evaluation of measurement properties of self-administered PROMs aimed at patients with non-specific shoulder pain and "activity limitations": a systematic review.

    Science.gov (United States)

    Thoomes-de Graaf, M; Scholten-Peeters, G G M; Schellingerhout, J M; Bourne, A M; Buchbinder, R; Koehorst, M; Terwee, C B; Verhagen, A P

    2016-09-01

    To critically appraise and compare the measurement properties of self-administered patient-reported outcome measures (PROMs) focussing on the shoulder, assessing "activity limitations." Systematic review. The study population had to consist of patients with shoulder pain. We excluded postoperative patients or patients with generic diseases. The methodological quality of the selected studies and the results of the measurement properties were critically appraised and rated using the COSMIN checklist. Out of a total of 3427 unique hits, 31 articles, evaluating 7 different questionnaires, were included. The SPADI is the most frequently evaluated PROM and its measurement properties seem adequate apart from a lack of information regarding its measurement error and content validity. For English, Norwegian and Turkish users, we recommend to use the SPADI. Dutch users could use either the SDQ or the SST. In German, we recommend the DASH. In Tamil, Slovene, Spanish and the Danish languages, the evaluated PROMs were not yet of acceptable validity. None of these PROMs showed strong positive evidence for all measurement properties. We propose to develop a new shoulder PROM focused on activity limitations, taking new knowledge and techniques into account.

  16. Proceedings of Patient Reported Outcome Measure?s (PROMs) Conference Sheffield 2016: advances in patient reported outcomes research

    OpenAIRE

    Croudace, Tim; Brazier, John; Gutacker, Nils; Street, Andrew; Robotham, Dan; Waterman, Samantha; Rose, Diana; Satkunanathan, Safarina; Wykes, Til; Nasr, Nasrin; Enderby, Pamela; Carlton, Jill; Rowen, Donna; Elliott, Jackie; Brazier, John

    2016-01-01

    Table of contents S1 Using computerized adaptive testing Tim Croudace S2 Well-being: what is it, how does it compare to health and what are the implications of using it to inform health policy John Brazier O1 “Am I going to get better?”—Using PROMs to inform patients about the likely benefit of surgery Nils Gutacker, Andrew Street O2 Identifying Patient Reported Outcome Measures for an electronic Personal Health Record Dan Robotham, Samantha Waterman, Diana Rose, Safarina Satkunanathan, Til W...

  17. Proceedings of Patient Reported Outcome Measure’s (PROMs Conference Sheffield 2016: advances in patient reported outcomes research

    Directory of Open Access Journals (Sweden)

    Tim Croudace

    2016-10-01

    Full Text Available Table of contents S1 Using computerized adaptive testing Tim Croudace S2 Well-being: what is it, how does it compare to health and what are the implications of using it to inform health policy John Brazier O1 “Am I going to get better?”—Using PROMs to inform patients about the likely benefit of surgery Nils Gutacker, Andrew Street O2 Identifying Patient Reported Outcome Measures for an electronic Personal Health Record Dan Robotham, Samantha Waterman, Diana Rose, Safarina Satkunanathan, Til Wykes O3 Examining the change process over time qualitatively: transformative learning and response shift Nasrin Nasr, Pamela Enderby O4 Developing a PROM to evaluate self-management in diabetes (HASMID: giving patients a voice Jill Carlton, Donna Rowen, Jackie Elliott, John Brazier, Katherine Stevens, Hasan Basarir, Alex Labeit O5 Development of the Primary Care Outcomes Questionnaire (PCOQ Mairead Murphy, Sandra Hollinghurst, Chris Salisbury O6 Developing the PKEX score- a multimodal assessment tool for patients with shoulder problems Dominic Marley, James Wilson, Amy Barrat, Bibhas Roy O7 Applying multiple imputation to multi-item patient reported outcome measures: advantages and disadvantages of imputing at the item, sub-scale or score level Ines Rombach, Órlaith Burke, Crispin Jenkinson, Alastair Gray, Oliver Rivero-Arias O8 Integrating Patient Reported Outcome Measures (PROMs into routine primary care for patients with multimorbidity: a feasibility study Ian Porter, Jaheeda Gangannagaripalli, Charlotte Bramwell, Jose M. Valderas O9 eRAPID: electronic self-report and management of adverse-events for pelvic radiotherapy (RT patients Patricia Holch, Susan Davidson, Jacki Routledge, Ann Henry, Kevin Franks, Alex Gilbert, Kate Absolom & Galina Velikova O10 Patient reported outcomes (PROMs based recommendation in clinical guidance for the management of chronic conditions in the United Kingdom Ian Porter, Jose M.Valderas O11 Cross-sectional and

  18. Improved decay rates for solutions for a multidimensional generalized Benjamin-Bona-Mahony equation

    KAUST Repository

    Said-Houari, Belkacem

    2014-01-01

    In this paper, we study the decay rates of solutions for the generalized Benjamin-Bona-Mahony equation in multi-dimensional space. For initial data in some L1-weighted spaces, we prove faster decay rates of the solutions. More precisely, using the Fourier transform and the energy method, we show the global existence and the convergence rates of the solutions under the smallness assumption on the initial data and we give better decay rates of the solutions. This result improves early works in J. Differential Equations 158(2) (1999), 314-340 and Nonlinear Anal. 75(7) (2012), 3385-3392. © 2014-IOS Press.

  19. The Fate of a Healing Goddess: Ocular Pathologies, the Antonine Plague, and the Ancient Roman Cult of Bona Dea

    Directory of Open Access Journals (Sweden)

    Leonardo Ambasciano

    2016-05-01

    Full Text Available The aim of this article is to offer a diachronic and dynamic contextualisation of the ancient Roman cult of Bona Dea, connecting its cognitive underpinnings with its healing dimension. Special attention is devoted to the ocular concerns attested in the epigraphic inventory. The decline of the presence of Bona Dea on the religious scene, attested by the 3rd century CE, is considered to be the multi-causal result of the long-lasting, ocular side-effects of smallpox in the aftermath of the so-called Antonine Plague, which interacted with the correlated and prolonged lack of positive reinforcement concerning symptom relief and cognitive feedback.

  20. Long-term Field Experiments as Important Source of Knowledge - Aims of the BonaRes Data Centre

    Science.gov (United States)

    Grosse, Meike; Hierold, Wilfried

    2017-04-01

    BonaRes is short for "soil as a sustainable resource for the bioeconomy". It is funded by the German Federal Ministry of Education and Research (BMBF) under the umbrella of the National Research Strategy BioEconomy 2030. BonaRes consists of ten interdisciplinary research project consortia and the 'BonaRes - Centre for Soil Research' (see also Wollschläger et al 2016). It is one task of the BonaRes Data Centre as part of the 'BonaRes - Centre for Soil Research', to collect data and meta-data of agricultural long-term field experiments (LTFE) in Germany. The definition of LTFE in the context of BonaRes is a minimum duration of twenty years and a static design. LTFE are essential research infrastructures for agricultural sciences and soil sciences amongst other disciplines. Some LTFE run since a very long time; the start of the oldest one in Germany was 1878. Therefore, in many cases valuable time series exist. Data sets of LTFE shall be compiled and made publicly available by the BonaRes Data Centre. The public availability together with an easy access will lead to an enhanced usability of the data. This probably makes the LTFE itself more valuable through an improved visibility and may also help to maintain the LTFE. Beyond the data compilation there is the possibility for every data owner to make a data publication, which offers an additional value for the data owner after his first right of use. A first step towards a joint database is a compilation of all existing LTFE in Germany with meta information to each trial. This information is shown in an interactive web map, what is completely new in that context. Besides the exact position of the LTFE the following metadata are shown: name of the LTFE, website (if available), institution, land use category, participation in existing networks, research theme, start (and maybe end) of the trial, and research parameters. Details on the meta information will be presented in the speech. Literature Wollschläger, U; Helming

  1. Investigaciones Terapéuticas en la Lepra: Ensayos con “Promín” o “Promanida'”

    Directory of Open Access Journals (Sweden)

    J. Ignacio Chala H.

    1948-07-01

    Full Text Available Con propósitos de observar, comprobar y valorar los resultados del "Promín"  o “Promanida” en la lepra, lo aplicarnos en un grupo de veintisiete enfermos seleccionados con criterio clínico y de investigación terapéutica. Iniciamos el estudio en julio de 1946. Ninguno de estos casos había sido tratado antes con otros medicamentos preconizados contra la enfermedad. Como lo he dicho en varias ocasiones, solamente teniendo esta precaución y seleccionando los pacientes para la investigación, podrá juzgarse científicamente de la eficacia terapéutica que puedan tener en los distintos tipos de lepra, las drogas aconsejadas para tratar esa enfermedad. Prescindimos de aquellos cases en los cuales, por lo avanzado del mal, los organismos no estaban en condiciones de reaccionar favorablemente con ninguna medicación.

  2. Psychometric validation of the Spanish version of the USS-PROM questionnaire for patients who undergo anterior urethral surgery.

    Science.gov (United States)

    Puche-Sanz, I; Martín-Way, D; Flores-Martín, J; Expósito-Ruiz, M; Vicente-Prados, J; Nogueras-Ocaña, M; Tinaut-Ranera, J; Cózar-Olmo, J M

    2016-06-01

    To translate into Spanish and validate the Urethral Stricture Surgery Patient-Reported Outcome Measure (USS-PROM) questionnaire, assessing its psychometric properties and determining its suitability for clinical use in our community. We also assessed the potential changes in ejaculatory function using the Male Sexual Health Questionnaire-Ejaculatory Dysfunction (MSHQ-EjD). A systematic translation of the British version was performed. Patients scheduled for anterior urethral stricture surgery between September 2014 and September 2015 were prospectively included in the study. All patients completed the questionnaire before and after the surgery. We conducted an in-depth psychometric study of the questionnaire. We assessed the responses of a total of 40 patients. The questionnaire showed its validity, presenting an excellent negative correlation between the voiding symptom scores and the maximum flow (r=-0.6, P<.001), and also showed significant improvement in the EQ5D-VAS (visual analogue scale) and the time trade-off. For internal consistency, the Cronbach's alpha was 0.701. For the test-retest reliability, the overall intraclass correlation coefficient (ICC) was 0.974, and the ICC for each item separately ranged from 0.799 to 0.980. We observed significant improvement in all items regarding urinary symptoms and health-related quality of life (P<.001), thereby demonstrating the response capacity to changing the questionnaire. There were no significant changes in the MSHQ-EjD. The Spanish version of the USS-PROM questionnaire is a valid instrument for quantifying changes in voiding symptoms and the health-related quality of life of patients undergoing anterior urethral surgery. Copyright © 2016 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  3. WS1: one more new Galactic bona fide luminous blue variable★

    Science.gov (United States)

    Kniazev, A. Y.; Gvaramadze, V. V.; Berdnikov, L. N.

    2015-04-01

    In this Letter, we report the results of spectroscopic and photometric monitoring of the candidate luminous blue variable (LBV) WS1, which was discovered in 2011 through the detection of a mid-infrared circular shell and follow-up optical spectroscopy of its central star. Our monitoring showed that WS1 brightened in the B, V and I bands by more than 1 mag during the last three years, while its spectrum revealed dramatic changes during the same time period, indicating that the star became much cooler. The light curve of WS1 demonstrates that the brightness of this star has reached maximum in 2013 December and then starts to decline. These findings unambiguously proved the LBV nature of WS1 and added one more member to the class of Galactic bona fide LBVs, bringing their number to sixteen (an updated census of these objects is provided).

  4. Discovery of a new Galactic bona fide luminous blue variable with Spitzer★

    Science.gov (United States)

    Gvaramadze, V. V.; Kniazev, A. Y.; Berdnikov, L. N.; Langer, N.; Grebel, E. K.; Bestenlehner, J. M.

    2014-11-01

    We report the discovery of a circular mid-infrared shell around the emission-line star Wray 16-137 using archival data of the Spitzer Space Telescope. Follow-up optical spectroscopy of Wray 16-137 with the Southern African Large Telescope revealed a rich emission spectrum typical of the classical luminous blue variables (LBVs) like P Cygni. Subsequent spectroscopic and photometric observations showed drastic changes in the spectrum and brightness during the last three years, meaning that Wray 16-137 currently undergoes an S Dor-like outburst. Namely, we found that the star has brightened by ≈1 mag in the V and Ic bands, while its spectrum became dominated by Fe II lines. Taken together, our observations unambiguously show that Wray 16-137 is a new member of the family of Galactic bona fide LBVs.

  5. Measurement properties of patient-reported outcome measures (PROMs) used in adult patients with chronic kidney disease: a systematic review protocol.

    Science.gov (United States)

    Aiyegbusi, Olalekan Lee; Kyte, Derek; Cockwell, Paul; Marshall, Tom; Keeley, Thomas; Gheorghe, Adrian; Calvert, Melanie

    2016-10-12

    Chronic kidney disease (CKD) is associated with symptoms that can significantly reduce the quality of life (QoL) of patients. Patient-reported outcome measures (PROMs) may facilitate the assessment of the impact of disease and treatment on the QoL, from a patient perspective. PROMs can be used in research and routine clinical practice. A systematic review of studies evaluating the measurement properties of PROMs in adults with CKD will be conducted. MEDLINE, EMBASE, PsycINFO and CINAHL Plus will be systematically searched from inception. Hand searching of reference lists and citations of included studies will be carried out. 2 reviewers will independently screen the titles and abstracts of all the studies retrieved during the systematic search to determine their eligibility. The COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) checklist will be used to appraise the methodological quality of the selected studies following the full-text review. Data on the study population, questionnaire characteristics and measurement properties will be extracted from the selected papers. Finally, a narrative synthesis of extracted data will be undertaken. Ethical permissions are not required for this study as data from published research articles will be used. Findings will be disseminated through publication in a peer-reviewed journal and presented at conferences. This systematic review will provide a comprehensive assessment of the measurement properties of PROMs currently available for use in adult patients with CKD and present evidence which may inform the selection of measures for use in research and clinical practice. CRD42016035554. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  6. MN48: a new Galactic bona fide luminous blue variable revealed by Spitzer and SALT

    Science.gov (United States)

    Kniazev, A. Y.; Gvaramadze, V. V.; Berdnikov, L. N.

    2016-07-01

    In this paper, we report the results of spectroscopic and photometric observations of the candidate evolved massive star MN48 disclosed via detection of a mid-infrared circular shell around it with the Spitzer Space Telescope. Follow-up optical spectroscopy of MN48 with the Southern African Large Telescope (SALT) carried out in 2011-2015 revealed significant changes in the spectrum of this star, which are typical of luminous blue variables (LBVs). The LBV status of MN48 was further supported by photometric monitoring which shows that in 2009-2011 this star has brightened by ≈0.9 and 1 mag in the V and Ic bands, respectively, then faded by ≈1.1 and 1.6 mag during the next four years, and apparently started to brighten again recently. The detected changes in the spectrum and brightness of MN48 make this star the 18th known Galactic bona fide LBV and increase the percentage of LBVs associated with circumstellar nebulae to more than 70 per cent. We discuss the possible birth place of MN48 and suggest that this star might have been ejected either from a putative star cluster embedded in the H II region IRAS 16455-4531 or the young massive star cluster Westerlund 1.

  7. Discovery of a new bona fide luminous blue variable in Norma

    Science.gov (United States)

    Gvaramadze, V. V.; Kniazev, A. Y.; Berdnikov, L. N.

    2015-12-01

    We report the results of optical spectroscopy of the candidate evolved massive star MN44 revealed via detection of a circular shell with the Spitzer Space Telescope. First spectra taken in 2009 May-June showed the Balmer lines in emission as well as numerous emission lines of iron, which is typical of luminous blue variables (LBVs) near the visual maximum. New observations carried out in 2015 May-September detected significant changes in the spectrum, indicating that the star became hotter. We found that these changes are accompanied by significant brightness variability of MN44. In particular, the Ic-band brightness decreased by ≈ 1.6 mag during the last six years and after reaching its minimum in 2015 June has started to increase. Using archival data, we also found that the Ic-band brightness increased by ≈3 mag in ≈30 yr preceding our observations. MN44 therefore represents the 17th known example of the Galactic bona fide LBVs. We detected a nitrogen-rich knot to the north-west of the star, which might represent an interstellar cloudlet interacting with the circumstellar shell. We discuss a possible association between MN44 and the INTEGRAL transient source of hard X-ray emission IGR J16327-4940, implying that MN44 might be either a colliding-wind binary or a high-mass X-ray binary.

  8. IC 3639 - A New Bona Fide Compton-Thick AGN Unveiled By NuSTAR

    Science.gov (United States)

    Boorman, Peter G.; Gandhi, P.; Alexander, D. M.; Annuar, A.; Ballantyne, D. R.; Bauer, F.; Boggs, S. E.; Brandt, W. N.; Brightman, M.; Christensen, F. E.; hide

    2016-01-01

    We analyze high-quality NuSTAR observations of the local (z = 0.011) Seyfert 2 active galactic nucleus (AGN) IC 3639, in conjunction with archival Suzaku and Chandra data. This provides the first broadband X-ray spectral analysis of the source, spanning nearly two decades in energy (0.5-30 keV). Previous X-ray observations of the source below 10 keV indicated strong reflection/obscuration on the basis of a pronounced iron fluorescence line at 6.4 keV. The hard X-ray energy coverage of NuSTAR, together with self-consistent toroidal reprocessing models, enables direct broadband constraints on the obscuring column density of the source. We find the source to be heavily Compton-thick (CTK) with an obscuring column in excess of 3.6 x 10(exp 24) cm(exp -2), unconstrained at the upper end. We further find an intrinsic 2-10 keV luminosity of log(sub 10) (L(sub 2-10 keV) [erg s(exp -1)])= 43.4(+0.6/-1.1) to 90% confidence, almost 400 times the observed flux, and consistent with various multiwavelength diagnostics. Such a high ratio of intrinsic to observed flux, in addition to an Fe-K(alpha) fluorescence line equivalent width exceeding 2 keV, is extreme among known bona fide CTK AGNs, which we suggest are both due to the high level of obscuration present around IC 3639. Our study demonstrates that broadband spectroscopic modeling with NuSTAR enables large corrections for obscuration to be carried out robustly and emphasizes the need for improved modeling of AGN tori showing intense iron fluorescence.

  9. The BonaRes Centre - A virtual institute for soil research in the context of a sustainable bio-economy

    Science.gov (United States)

    Wollschläger, Ute; Helming, Katharina; Heinrich, Uwe; Bartke, Stephan; Kögel-Knabner, Ingrid; Russell, David; Eberhardt, Einar; Vogel, Hans-Jörg

    2016-04-01

    Fertile soils are central resources for the production of biomass and provision of food and energy. A growing world population and latest climate targets lead to an increasing demand for both, food and bio-energy, which require preserving and improving the long-term productivity of soils as a bio-economic resource. At the same time, other soil functions and ecosystem services need to be maintained. To render soil management sustainable, we need to establish a scientific knowledge base about complex soil system processes that allows for the development of model tools to quantitatively predict the impact of a multitude of management measures on soil functions. This, finally, will allow for the provision of site-specific options for sustainable soil management. To face this challenge, the German Federal Ministry of Education and Research recently launched the funding program "Soil as a Natural Resource for the Bio-Economy - BonaRes". In a joint effort, ten collaborative projects and the coordinating BonaRes Centre are engaged to close existing knowledge gaps for a profound and systemic understanding of soil functions and their sensitivity to soil management. This presentation provides an overview of the concept of the BonaRes Centre which is responsible for i) setting up a comprehensive data base for soil-related information, ii) the development of model tools aiming to estimate the impact of different management measures on soil functions, and iii) establishing a web-based portal providing decision support tools for a sustainable soil management. A specific focus of the presentation will be laid on the so-called "knowledge-portal" providing the infrastructure for a community effort towards a comprehensive meta-analysis on soil functions as a basis for future model developments.

  10. A Resource for the Transcriptional Signature of Bona Fide Trophoblast Stem Cells and Analysis of Their Embryonic Persistence

    Directory of Open Access Journals (Sweden)

    Georg Kuales

    2015-01-01

    Full Text Available Trophoblast stem cells (TSCs represent the multipotent progenitors that give rise to the different cells of the embryonic portion of the placenta. Here, we analysed the expression of key TSC transcription factors Cdx2, Eomes, and Elf5 in the early developing placenta of mouse embryos and in cultured TSCs and reveal surprising heterogeneity in protein levels. We analysed persistence of TSCs in the early placenta and find that TSCs remain in the chorionic hinge until E9.5 and are lost shortly afterwards. To define the transcriptional signature of bona fide TSCs, we used inducible gain- and loss-of-function alleles of Eomes or Cdx2, and EomesGFP, to manipulate and monitor the core maintenance factors of TSCs, followed by genome-wide expression profiling. Combinatorial analysis of resulting expression profiles allowed for defining novel TSC marker genes that might functionally contribute to the maintenance of the TSC state. Analyses by qRT-PCR and in situ hybridisation validated novel TSC- and chorion-specific marker genes, such as Bok/Mtd, Cldn26, Duox2, Duoxa2, Nr0b1, and Sox21. Thus, these expression data provide a valuable resource for the transcriptional signature of bona fide and early differentiating TSCs and may contribute to an increased understanding of the transcriptional circuitries that maintain and/or establish stemness of TSCs.

  11. Nonlocal Symmetries, Conservation Laws and Interaction Solutions of the Generalised Dispersive Modified Benjamin-Bona-Mahony Equation

    Science.gov (United States)

    Yan, Xue-Wei; Tian, Shou-Fu; Dong, Min-Jie; Wang, Xiu-Bin; Zhang, Tian-Tian

    2018-05-01

    We consider the generalised dispersive modified Benjamin-Bona-Mahony equation, which describes an approximation status for long surface wave existed in the non-linear dispersive media. By employing the truncated Painlevé expansion method, we derive its non-local symmetry and Bäcklund transformation. The non-local symmetry is localised by a new variable, which provides the corresponding non-local symmetry group and similarity reductions. Moreover, a direct method can be provided to construct a kind of finite symmetry transformation via the classic Lie point symmetry of the normal prolonged system. Finally, we find that the equation is a consistent Riccati expansion solvable system. With the help of the Jacobi elliptic function, we get its interaction solutions between solitary waves and cnoidal periodic waves.

  12. 1500 Years of Annual Climate and Environmental Variability as Recorded in Bona-Churchill (Alaska) Ice Cores

    Science.gov (United States)

    Thompson, L. G.; Mosley-Thompson, E. S.; Zagorodnov, V.; Davis, M. E.; Mashiotta, T. A.; Lin, P.

    2004-12-01

    In 2003, six ice cores measuring 10.5, 11.5, 11.8, 12.4, 114 and 460 meters were recovered from the col between Mount Bona and Mount Churchill (61° 24'N; 141° 42'W; 4420 m asl). These cores have been analyzed for stable isotopic ratios, insoluble dust content and concentrations of major chemical species. Total Beta radioactivity was measured in the upper sections. The 460-meter core, extending to bedrock, captured the entire depositional record at this site where ice temperatures ranged from -24° C at 10 meters to -19.8° C at the ice/bedrock contact. The shallow cores allow assessment of surface processes under modern meteorological conditions while the deep core offers a ˜1500-year climate and environmental perspective. The average annual net balance is ˜~1000 mm of water equivalent and distinct annual signals in dust and calcium concentrations along with δ 18O allow annual resolution over most of the core. The excess sulfate record reflects many known large volcanic eruptions such as Katmai, Krakatau, Tambora, and Laki which allow validation of the time scale in the upper part of the core. The lower part of the core yields a history of earlier volcanic events. The 460-m Bona-Churchill ice core provides a detailed history of the `Little Ice Age' and medieval warm periods for southeastern Alaska. The source of the White River Ash will be discussed in light of the evidence from this core. The 460-m core also provides a long-term history of the dust fall that originates in north-central China. The annual ice core-derived climate records from southeastern Alaska will facilitate an investigation of the likelihood that the high resolution 1500-year record from the tropical Quelccaya Ice Cap (Peru) preserves a history of the variability of both the PDO and the Aleutian Low.

  13. Using Patient-Reported Outcome Measures (PROMs) to promote quality of care and safety in the management of patients with Advanced Chronic Kidney disease (PRO-trACK project): a mixed-methods project protocol.

    Science.gov (United States)

    Aiyegbusi, Olalekan Lee; Kyte, Derek; Cockwell, Paul; Marshall, Tom; Dutton, Mary; Slade, Anita; Marklew, Neil; Price, Gary; Verdi, Rav; Waters, Judi; Sharpe, Keeley; Calvert, Melanie

    2017-06-30

    Advanced chronic kidney disease (CKD) has a major effect on the quality of life and health status of patients and requires accurate and responsive management. The use of electronic patient-reported outcome measures (ePROMs) could assist patients with advanced pre-dialysis CKD, and the clinicians responsible for their care, by identifying important changes in symptom burden in real time. We report the protocol for 'Using Patient-Reported Outcome measures (PROMs) to promote quality of care and safety in the management of patients with Advanced Chronic Kidney Disease' (PRO-trACK) project, which will explore the feasibility and validity of an ePROM system for use in patients with advanced CKD. The project will use a mixed-methods approach in three studies: (1) usability testing of the ePROM system involving up to 30 patients and focusing on acceptability and technical performance/stability; (2) ascertaining the views of patient and clinician stakeholders on the optimal use and administration of the CKD ePROM system-this will involve qualitative face-to-face/telephone interviewing with up to 30 patients or until saturation is achieved, focus groups with up to 15 clinical staff, management and IT team members; (3) psychometric assessment of the system, within a cohort of at least 180 patients with advanced CKD, to establish the measurement properties of the ePROM. This project was approved by the West Midlands Edgbaston Research Ethics Committee (Reference 17/WM/0010) and received Health Research Authority (HRA) approval on 24 February 2017.The findings from this project will be provided to clinicians at the Department of Renal Medicine, Queen Elizabeth Hospitals, Birmingham (QEHB), NHS England, presented at conferences and to the Kidney Patients' Association, British Kidney Patient Association and the British Renal Society. Articles based on the findings will be written and submitted for publication in peer-reviewed journals. © Article author(s) (or their employer

  14. Getting the Message? Native Reactive Electrophiles Pass Two Out of Three Thresholds to be Bona Fide Signaling Mediators.

    Science.gov (United States)

    Poganik, Jesse R; Long, Marcus J C; Aye, Yimon

    2018-05-01

    Precision cell signaling activities of reactive electrophilic species (RES) are arguably among the most poorly-understood means to transmit biological messages. Latest research implicates native RES to be a chemically-distinct subset of endogenous redox signals that influence cell decision making through non-enzyme-assisted modifications of specific proteins. Yet, fundamental questions remain regarding the role of RES as bona fide second messengers. Here, we lay out three sets of criteria we feel need to be met for RES to be considered as true cellular signals that directly mediate information transfer by modifying "first-responding" sensor proteins. We critically assess the available evidence and define the extent to which each criterion has been fulfilled. Finally, we offer some ideas on the future trajectories of the electrophile signaling field taking inspiration from work that has been done to understand canonical signaling mediators. Also see the video abstract here: https://youtu.be/rG7o0clVP0c. © 2018 WILEY Periodicals, Inc.

  15. Cross-cultural adaptation and measurement properties of generic and cancer-related patient-reported outcome measures (PROMs) for use with cancer patients in Brazil: a systematic review.

    Science.gov (United States)

    Albach, Carlos Augusto; Wagland, Richard; Hunt, Katherine J

    2018-04-01

    This systematic review (1) identifies the current generic and cancer-related patient-reported outcome measures (PROMs) that have been cross-culturally adapted to Brazilian Portuguese and applied to cancer patients and (2) critically evaluates their cross-cultural adaptation (CCA) and measurement properties. Seven databases were searched for articles regarding the translation and evaluation of measurement properties of generic and cancer-related PROMs cross-culturally adapted to Brazilian Portuguese that are applied in adult (≥18 years old) cancer patients. The methodological quality of included studies was assessed using the COSMIN checklist. The bibliographic search retrieved 1674 hits, of which seven studies analysing eight instruments were included in this review. Data on the interpretability of scores were poorly reported. Overall, the quality of the CCA process was inconsistent throughout the studies. None of the included studies performed a cross-cultural validation. The evidence concerning the quality of measurement properties is limited by poor or fair methodological quality. Moreover, limited information regarding measurement properties was provided within the included papers. This review aids the selection process of Brazilian Portuguese PROMs for use in cancer patients. After acknowledging the methodological caveats and strengths of each tool, our opinion is that for quality of life and symptoms assessment the adapted FACT-G version and the ESAS could be recommended, respectively. Future research should rely on the already accepted standards of CCA and validation studies.

  16. IC 3639—a New Bona Fide Compton-Thick AGN Unveiled by NuSTAR

    Science.gov (United States)

    Boorman, Peter G.; Gandhi, P.; Alexander, D. M.; Annuar, A.; Ballantyne, D. R.; Bauer, F.; Boggs, S. E.; Brandt, W. N.; Brightman, M.; Christensen, F. E.; Craig, W. W.; Farrah, D.; Hailey, C. J.; Harrison, F. A.; Hönig, S. F.; Koss, M.; LaMassa, S. M.; Masini, A.; Ricci, C.; Risaliti, G.; Stern, D.; Zhang, W. W.

    2016-12-01

    We analyze high-quality NuSTAR observations of the local (z = 0.011) Seyfert 2 active galactic nucleus (AGN) IC 3639, in conjunction with archival Suzaku and Chandra data. This provides the first broadband X-ray spectral analysis of the source, spanning nearly two decades in energy (0.5-30 keV). Previous X-ray observations of the source below 10 keV indicated strong reflection/obscuration on the basis of a pronounced iron fluorescence line at 6.4 keV. The hard X-ray energy coverage of NuSTAR, together with self-consistent toroidal reprocessing models, enables direct broadband constraints on the obscuring column density of the source. We find the source to be heavily Compton-thick (CTK) with an obscuring column in excess of 3.6× {10}24 cm-2, unconstrained at the upper end. We further find an intrinsic 2-10 keV luminosity of {{log}}10({L}2{--10{keV}} [{erg} {{{s}}}-1])={43.4}-1.1+0.6 to 90% confidence, almost 400 times the observed flux, and consistent with various multiwavelength diagnostics. Such a high ratio of intrinsic to observed flux, in addition to an Fe-Kα fluorescence line equivalent width exceeding 2 keV, is extreme among known bona fide CTK AGNs, which we suggest are both due to the high level of obscuration present around IC 3639. Our study demonstrates that broadband spectroscopic modeling with NuSTAR enables large corrections for obscuration to be carried out robustly and emphasizes the need for improved modeling of AGN tori showing intense iron fluorescence.

  17. Prom Health and Safety Tips

    Science.gov (United States)

    ... cost is an issue, look for alternatives to spending a lot of money. Expensive doesn't necessarily mean better. Plan ahead for safety Tell family members or a trusted adult what your plans are ahead of time. Make an agreement with friends to check on ...

  18. Discrimination-pregnancy leave-Pregnancy Discrimination Act not retroactive-bona fide seniority system. AT&T Corp. v. Hulteen, 2009 U.S. LEXIS 3470 (U.S. 5/18/2009).

    Science.gov (United States)

    2009-01-01

    A pension plan whose terms are those of a bona fide seniority system and which treats pregnancy leave, taken before the addition of the Pregnancy Discrimination Act (PDA) to Title VII, differently than other kinds of medical leave, does not amount to sex and pregnancy discrimination under Title VII because PDA does not apply retroactively.

  19. Využití měr variability pro nominální proměnné ve vícerozměrné statistické analýze

    Czech Academy of Sciences Publication Activity Database

    Řezanková, Hana; Šulc, Z.; Húsek, Dušan

    2016-01-01

    Roč. 12, č. 1 (2016), s. 34-43 ISSN 1336-7420 Grant - others:IGA VŠE(CZ) F4/41/2016 Institutional support: RVO:67985807 Keywords : míry variability * nominální proměnné * vícerozměrná analýza * míry závislosti * míry podobnosti * shluková analýza * rozhodovací stromy * hodnocení klasifikace * variability measures * nominal variables * multivariate analysis * dependence measures * similarity measures * cluster analysis * decision trees * classification evaluation Subject RIV: BB - Applied Statistics, Operational Research http://www.ssds.sk/casopis/archiv/2016/fss0116.pdf

  20. 15 February 2012 - Geneva United Nations Office Director-General K.-J. Tokayev in the LHC tunnel with Adviser for Relations with international organisations M. Bona and Technology Department Head F. Bordry.

    CERN Multimedia

    Jean-claude Gadmer

    2012-01-01

    Kassym-Jomart Tokayev, director-general of the United Nations Office at Geneva, (centre picture 02), visited CERN on 15 February. He toured the LHC tunnel with Maurizio Bona, CERN’s adviser to the director-general, relations with international organizations, left, and Frédérick Bordry, CERN’s technology department head. He also visited the ATLAS underground experimental area, as well as the exhibition at the Globe of Science and Innovation.

  1. SCFJFK is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer

    Science.gov (United States)

    Yan, Ruorong; He, Lin; Li, Zhongwu; Han, Xiao; Liang, Jing; Si, Wenzhe; Chen, Zhe; Li, Lei; Xie, Guojia; Li, Wanjin; Wang, Peiyan; Lei, Liandi; Zhang, Hongquan; Pei, Fei; Cao, Dengfeng

    2015-01-01

    Loss of function/dysregulation of inhibitor of growth 4 (ING4) and hyperactivation of NF-κB are frequent events in many types of human malignancies. However, the molecular mechanisms underlying these remarkable aberrations are not understood. Here, we report that ING4 is physically associated with JFK. We demonstrated that JFK targets ING4 for ubiquitination and degradation through assembly of an Skp1–Cul1–F-box (SCF) complex. We showed that JFK-mediated ING4 destabilization leads to the hyperactivation of the canonical NF-κB pathway and promotes angiogenesis and metastasis of breast cancer. Significantly, the expression of JFK is markedly up-regulated in breast cancer, and the level of JFK is negatively correlated with that of ING4 and positively correlated with an aggressive clinical behavior of breast carcinomas. Our study identified SCFJFK as a bona fide E3 ligase for ING4 and unraveled the JFK–ING4–NF-κB axis as an important player in the development and progression of breast cancer, supporting the pursuit of JFK as a potential target for breast cancer intervention. PMID:25792601

  2. SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer.

    Science.gov (United States)

    Yan, Ruorong; He, Lin; Li, Zhongwu; Han, Xiao; Liang, Jing; Si, Wenzhe; Chen, Zhe; Li, Lei; Xie, Guojia; Li, Wanjin; Wang, Peiyan; Lei, Liandi; Zhang, Hongquan; Pei, Fei; Cao, Dengfeng; Sun, Luyang; Shang, Yongfeng

    2015-03-15

    Loss of function/dysregulation of inhibitor of growth 4 (ING4) and hyperactivation of NF-κB are frequent events in many types of human malignancies. However, the molecular mechanisms underlying these remarkable aberrations are not understood. Here, we report that ING4 is physically associated with JFK. We demonstrated that JFK targets ING4 for ubiquitination and degradation through assembly of an Skp1-Cul1-F-box (SCF) complex. We showed that JFK-mediated ING4 destabilization leads to the hyperactivation of the canonical NF-κB pathway and promotes angiogenesis and metastasis of breast cancer. Significantly, the expression of JFK is markedly up-regulated in breast cancer, and the level of JFK is negatively correlated with that of ING4 and positively correlated with an aggressive clinical behavior of breast carcinomas. Our study identified SCF(JFK) as a bona fide E3 ligase for ING4 and unraveled the JFK-ING4-NF-κB axis as an important player in the development and progression of breast cancer, supporting the pursuit of JFK as a potential target for breast cancer intervention. © 2015 Yan et al.; Published by Cold Spring Harbor Laboratory Press.

  3. Functional validation of putative toxin-antitoxin genes from the Gram-positive pathogen Streptococcus pneumoniae: phd-doc is the fourth bona-fide operon.

    Science.gov (United States)

    Chan, Wai Ting; Yeo, Chew Chieng; Sadowy, Ewa; Espinosa, Manuel

    2014-01-01

    Bacterial toxin-antitoxin (TAs) loci usually consist of two genes organized as an operon, where their products are bound together and inert under normal conditions. However, under stressful circumstances the antitoxin, which is more labile, will be degraded more rapidly, thereby unleashing its cognate toxin to act on the cell. This, in turn, causes cell stasis or cell death, depending on the type of TAs and/or time of toxin exposure. Previously based on in silico analyses, we proposed that Streptococcus pneumoniae, a pathogenic Gram-positive bacterium, may harbor between 4 and 10 putative TA loci depending on the strains. Here we have chosen the pneumococcal strain Hungary(19A)-6 which contains all possible 10 TA loci. In addition to the three well-characterized operons, namely relBE2, yefM-yoeB, and pezAT, we show here the functionality of a fourth operon that encodes the pneumococcal equivalent of the phd-doc TA. Transcriptional fusions with gene encoding Green Fluorescent Protein showed that the promoter was slightly repressed by the Phd antitoxin, and exhibited almost background values when both Phd-Doc were expressed together. These findings demonstrate that phd-doc shows the negative self-regulatory features typical for an authentic TA. Further, we also show that the previously proposed TAs XreA-Ant and Bro-XreB, although they exhibit a genetic organization resembling those of typical TAs, did not appear to confer a functional behavior corresponding to bona fide TAs. In addition, we have also discovered new interesting bioinformatics results for the known pneumococcal TAs RelBE2 and PezAT. A global analysis of the four identified toxins-antitoxins in the pneumococcal genomes (PezAT, RelBE2, YefM-YoeB, and Phd-Doc) showed that RelBE2 and Phd-Doc are the most conserved ones. Further, there was good correlation among TA types, clonal complexes and sequence types in the 48 pneumococcal strains analyzed.

  4. 23rd June 2010 - IATA Director-General and CEO G. Bisignani signing the guest book with Research and Computing Director S. Bertolucci; visiting the LHC superconducting magnet test hall with L. Bottura; throughout accompanied by Adviser for International relations M. Bona.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    23rd June 2010 - IATA Director-General and CEO G. Bisignani signing the guest book with Research and Computing Director S. Bertolucci; visiting the LHC superconducting magnet test hall with L. Bottura; throughout accompanied by Adviser for International relations M. Bona.

  5. 26th August 2010 - World Meteorological Organization Secretary-General M. Jarraud signing the guest book with CERN Director-General R. Heuer and visiting the LHC superconducting magnet test hall with Technology Department Head F. Bordry; throughout accompanied by M. Bona, CERN Relations with International Organisations

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    26th August 2010 - World Meteorological Organization Secretary-General M. Jarraud signing the guest book with CERN Director-General R. Heuer and visiting the LHC superconducting magnet test hall with Technology Department Head F. Bordry; throughout accompanied by M. Bona, CERN Relations with International Organisations

  6. Proměny Corporate Social Responsibility

    OpenAIRE

    Knížová, Kristýna

    2014-01-01

    In 1953, Howard R. Bowen gave rise to the debate on social responsibility, and since then it has become very widespread. The concept of Corporate Social Responsibility gained a lot of forms during the second half of the twentieth century and from the university campuses got into practice and also into the Czech Republic. On the background of changing theoretical approaches toward CSR we can see changes of business environment - especially in the change of the conceptualization of the enterpri...

  7. 15th December 2010 - World Intellectual Property Organization Director-General F. Gurry signing the guest book with CERN Director-General R. Heuer; visiting CMS control room, experimental cavern and LHC tunnel with Collaboration Deputy Spokesperson J. Incandela, accompanied by M. Bona.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    CERN-HI-1012325 36, from left to right: WIPO Arbitration and Mediation Center, Global Issues Sector Director E. Wilbers; CERN Adviser, Relations with International Organisations, M. Bona; CMS Collaboration Deputy Spokesperson, University of California Santa Barbara J. Incandela; WIPO Deputy Director General, Global Issues Sector J. C. Wichard; WIPO Director-General F. Gurry; WIPO Executive Director and Chief of Staff, Office of the Director General N. Prasad.

  8. CRISPR/Cas9 Mediated GFP Knock-in at the MAP1LC3B Locus in 293FT Cells Is Better for Bona Fide Monitoring Cellular Autophagy.

    Science.gov (United States)

    Wu, Zhiqiang; Zhao, Jinlin; Qiu, Minghan; Mi, Zeyun; Meng, Maobin; Guo, Yu; Wang, Hui; Yuan, Zhiyong

    2018-04-19

    Accurately identifying and quantifying cellular autophagy is very important as the significance of autophagy in physiological and pathological processes becomes increasingly evident. Ectopically expressed fluorescent-tagged microtubule-associated protein light chain 3B (MAP1LC3B, LC3) is the most widely used reporter for monitoring autophagy activity thus far. However, this approach ignores the influence of constitutively overexpressed LC3 on autophagy itself and autophagy-related processes and its accuracy in indicating autophagy is questionable. Here, we generated a knock-in GFP-LC3 reporter via the CRISPR/Cas9 system in 293FT cells to add GFP to the N-terminal of and in frame with endogenous LC3. We proved that this knock-in GFP-LC3 was expressed at biological level driven by the endogenous transcriptional regulatory elements as the wild type alleles. Compared with the ectopically expressed GFP-LC3, the endogenous knock-in reporter exhibited much higher sensitivity and signal-to-noise ratio of GFP-LC3 puncta upon the induction or inhibition of autophagy at certain step for monitoring autophagy activity. Thus, according to the previous reported concerning and the results presented here, we suggest that this knock-in GFP-LC3 reporter is better for bona fide monitoring cellular autophagy and should be employed for further study of autophagy in vitro and in vivo. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. DZ Chamaeleontis: a bona fide photoevaporating disc

    Science.gov (United States)

    Canovas, H.; Montesinos, B.; Schreiber, M. R.; Cieza, L. A.; Eiroa, C.; Meeus, G.; de Boer, J.; Ménard, F.; Wahhaj, Z.; Riviere-Marichalar, P.; Olofsson, J.; Garufi, A.; Rebollido, I.; van Holstein, R. G.; Caceres, C.; Hardy, A.; Villaver, E.

    2018-02-01

    Context. DZ Cha is a weak-lined T Tauri star (WTTS) surrounded by a bright protoplanetary disc with evidence of inner disc clearing. Its narrow Hα line and infrared spectral energy distribution suggest that DZ Cha may be a photoevaporating disc. Aims: We aim to analyse the DZ Cha star + disc system to identify the mechanism driving the evolution of this object. Methods: We have analysed three epochs of high resolution optical spectroscopy, photometry from the UV up to the sub-mm regime, infrared spectroscopy, and J-band imaging polarimetry observations of DZ Cha. Results: Combining our analysis with previous studies we find no signatures of accretion in the Hα line profile in nine epochs covering a time baseline of 20 yr. The optical spectra are dominated by chromospheric emission lines, but they also show emission from the forbidden lines [SII] 4068 and [OI] 6300Å that indicate a disc outflow. The polarized images reveal a dust depleted cavity of 7 au in radius and two spiral-like features, and we derive a disc dust mass limit of Mdust 80 MJup) companions are detected down to 0.̋07 ( 8 au, projected). Conclusions: The negligible accretion rate, small cavity, and forbidden line emission strongly suggests that DZ Cha is currently at the initial stages of disc clearing by photoevaporation. At this point the inner disc has drained and the inner wall of the truncated outer disc is directly exposed to the stellar radiation. We argue that other mechanisms like planet formation or binarity cannot explain the observed properties of DZ Cha. The scarcity of objects like this one is in line with the dispersal timescale (≲105 yr) predicted by this theory. DZ Cha is therefore an ideal target to study the initial stages of photoevaporation. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programme 097.C-0536. Based on data obtained from the ESO Science Archive Facility under request number 250112.

  10. Glioblastoma formation from cell population depleted of Prominin1-expressing cells.

    Directory of Open Access Journals (Sweden)

    Kenji Nishide

    2009-08-01

    Full Text Available Prominin1 (Prom1, also known as CD133 in human has been widely used as a marker for cancer stem cells (CSCs, which self-renew and are tumorigenic, in malignant tumors including glioblastoma multiforme (GBM. However, there is other evidence showing that Prom1-negative cancer cells also form tumors in vivo. Thus it remains controversial whether Prom1 is a bona fide marker for CSCs. To verify if Prom1-expressing cells are essential for tumorigenesis, we established a mouse line, whose Prom1-expressing cells can be eliminated conditionally by a Cre-inducible DTA gene on the Prom1 locus together with a tamoxifen-inducible CreER(TM, and generated glioma-initiating cells (GICs-LD by overexpressing both the SV40 Large T antigen and an oncogenic H-Ras(L61 in neural stem cells of the mouse line. We show here that the tamoxifen-treated GICs-LD (GICs-DTA form tumor-spheres in culture and transplantable GBM in vivo. Thus, our studies demonstrate that Prom1-expressing cells are dispensable for gliomagenesis in this mouse model.

  11. Discovering, analyzing and enhancing BPMN models using ProM

    NARCIS (Netherlands)

    Kalenkova, A.A.; Leoni, de M.; Aalst, van der W.M.P.; Limonad, L.; Weber, B.

    2014-01-01

    Process mining techniques relate observed behavior to modeled behavior, e.g., the automatic discovery of a process model based on an event log. Process mining is not limited to process discovery and also includes conformance checking and model enhancement. Conformance checking techniques are used to

  12. Mining student capstone projects with FRASR and ProM

    NARCIS (Netherlands)

    Poncin, W.; Serebrenik, A.; Brand, van den M.G.J.

    2011-01-01

    Capstone projects are commonly carried out at the end of an undergraduate program of study in software engineering or computer science. While traditionally such projects solely focussed on the software product to be developed, in more recent work importance of the development process has been

  13. 29 August 2013 - J.-F. Jauslin, Directeur de l’Office fédéral de la culture (OFC) Ambassadeur suisse auprès de l’UNESCO et de l’OIF au 1er septembre 2013 Confédération suisse visite le centre visiteurs de l’expérience ATLAS ainsi que la caverne expérimentale d'ATLAS avec P. Jenny, ancien Porte-parole d'ATLAS. M. Bona, Conseiller du Directeur général pour les relations avec les Organisations internationales présent tout au long.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    29 August 2013 - J.-F. Jauslin, Directeur de l’Office fédéral de la culture (OFC) Ambassadeur suisse auprès de l’UNESCO et de l’OIF au 1er septembre 2013 Confédération suisse visite le centre visiteurs de l’expérience ATLAS ainsi que la caverne expérimentale d'ATLAS avec P. Jenny, ancien Porte-parole d'ATLAS. M. Bona, Conseiller du Directeur général pour les relations avec les Organisations internationales présent tout au long.

  14. 29 CFR 1625.8 - Bona fide seniority systems.

    Science.gov (United States)

    2010-07-01

    ... equitable allocation of available employment opportunities and prerogatives among younger and older workers. (b) Adoption of a purported seniority system which gives those with longer service lesser rights, and... upon the circumstances, be a “subterfuge to evade the purposes” of the Act. (c) Unless the essential...

  15. A bona fide baby boom for the Baltics / Aleksei Gunter

    Index Scriptorium Estoniae

    Gunter, Aleksei, 1979-

    2004-01-01

    Seoses jaanuaris alanud vanemahüvitise programmiga ennustatakse sel aastal sündide arvu tõusu. Rahvastikuminister Paul-Eerik Rummo kommentaare. Tabel: Eesti rahvastikuandmed aprill 2003 - aprill 2004

  16. Peaceful Uses Bona Fides: Criteria for Evaluation and Case Studies

    Energy Technology Data Exchange (ETDEWEB)

    Ajemian, Chris K.; Hazel, Mike; Kessler, Carol E.; Mathews, Carrie E.; Morris, Fred A.; Seward, Amy M.; Peterson, Danielle J.; Smith, Brian W.

    2007-06-06

    This study applies a set of indicators to assess the peaceful nature of a state’s nuclear program. Evaluation of a country’s nuclear program relative to these indicators can help the international community to take appropriate actions to ensure that the growth of the global nuclear energy industry proceeds peacefully and to minimize nuclear proliferation risks.

  17. Bona Fide Thermodynamic Temperature in Nonequilibrium Kinetic Ising Models

    OpenAIRE

    Sastre, Francisco; Dornic, Ivan; Chaté, Hugues

    2003-01-01

    We show that a nominal temperature can be consistently and uniquely defined everywhere in the phase diagram of large classes of nonequilibrium kinetic Ising spin models. In addition, we confirm the recent proposal that, at critical points, the large-time ``fluctuation-dissipation ratio'' $X_\\infty$ is a universal amplitude ratio and find in particular $X_\\infty \\approx 0.33(2)$ and $X_\\infty = 1/2$ for the magnetization in, respectively, the two-dimensional Ising and voter universality classes.

  18. Solitons, compactons and undular bores in Benjamin–Bona ...

    Indian Academy of Sciences (India)

    2017-01-04

    Jan 4, 2017 ... In order to understand the role of nonlinear disper- sion in the formation of patterns in waves governed ... tems, the point at which two compactons collide is marked by the birth of a low-amplitude compacton– .... first-order equation (11) can easily be integrated to write y as a function of ξ for all values of c.

  19. Proměny sporu o svobodu české filosofie

    Czech Academy of Sciences Publication Activity Database

    Hermann, Tomáš

    2012-01-01

    Roč. 61, mimoř. č. (2012), s. 49-73 ISSN 0015-1831. [České myšlení. Česká filosofie a česká kritická teorie. Praha, 07.11.2011-09.11.2011] R&D Projects: GA ČR GPP410/10/P550 Institutional support: RVO:68378114 Keywords : Czech philosophy * Hegelianism * Herbartism Subject RIV: AB - History

  20. Le Prométhée enchaîné de Camus

    DEFF Research Database (Denmark)

    Lund, Hans Peter

    2008-01-01

    Et hidtil upåagtet manuskript af Albert Camus, "Den lænkede Prometheus", efter Aischylos, præsenteres og gennemgås i forhold til forlægget. Dets relevans for revolte-temaet i Camus' forfatterskab påvises, og dette tema perspektiveres i forhold til Hölderlins Empedokles, som Camus læste, til hans...

  1. Simulation of flash dehydroxylation of clay particle using gPROMS

    DEFF Research Database (Denmark)

    Gebremariam, Abraham Teklay; Bøjer, Martin; Adelsward, Anicka

    2014-01-01

    The use of SCMs (supplementary cementitious materials) to replace part of the clinker in cement industry is gaining an increasing interest in order to reduce the CO2 footprint. The abundantly available clay minerals are potential sources of SCMs. Thermal treatment of kaolinite clay under moderate...

  2. The Visual Analog Scale as a Comprehensible Patient-Reported Outcome Measure (PROM) in Septorhinoplasty.

    Science.gov (United States)

    Spiekermann, Christoph; Amler, Susanne; Rudack, Claudia; Stenner, Markus

    2018-06-01

    The patient's satisfaction with the esthetic result is a major criterion of success in septorhinoplasty. However, the idea of esthetic perfection varies greatly and primarily depends on subjective perception. Hence, patient-reported instruments are important and necessary to assess the outcome in septorhinoplasty. To analyze the potential of the visual analog scale (VAS) as a patient-reported outcome measure in septorhinoplasty, the perception of the nasal appearance was assessed by a VAS pre- and postoperatively in 213 patients undergoing septorhinoplasty. Furthermore, in this prospective study, the patients' satisfaction concerning the procedure's result was analyzed using a five-point Likert scale. Females had lower preoperative VAS scores but a higher increase compared to males. Patients with lower initial VAS scores showed a higher improvement in the VAS score postoperatively compared to patients with higher initial VAS scores. Satisfaction with the result depends on the increase in the VAS score value. The VAS scale is a short and comprehensible tool to assess patients' perception of nasal appearance preoperatively and represents an appropriate instrument to assess the esthetic patient-reported outcome in septorhinoplasty.Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

  3. Jan Hus v proměnách šesti století

    Czech Academy of Sciences Publication Activity Database

    Čornej, Petr

    2015-01-01

    Roč. 17, č. 4 (2015), s. 19-35 ISSN 1212-8570 R&D Projects: GA ČR(CZ) GBP405/12/G148 Institutional support: RVO:68378092 Keywords : Jan Hus * Hussitism * historical tradition * František Palacký * Czech Lands * Catholic church * communist concept Subject RIV: AB - History

  4. Marketing společnosti Apple a jeho proměna po roce 2011

    OpenAIRE

    Rybář, Martin

    2016-01-01

    Thesis on "The Marketing Strategies of Apple Inc. and Their Change After 2011" deals with the transformation of Apple's marketing strategies after the death of Steve Jobs, who was regarded by many as a key figure in the whole company. The author aims to present the company, products and marketing strategies used by Steve Jobs and then analyze the changes that have been made by new CEO Tim Cook since 2011. The theoretical part is devoted to definitions, which the author will be using in the pr...

  5. Knoflík v proměnách času

    OpenAIRE

    STRÁNSKÁ, Daniela

    2007-01-01

    My diploma work objective describe history of the development of claps and butooms from primeval age to the present times. I desribe the development of the claps with brief development from the primeval age to 19th. century of the fashion. One part of my diploma work is obout manufacture of the butooms in Czech. In 18th. and 19th. century is typical homework´s manufacture of the butooms in Czech. The another chapters describe these manufacture of the butooms. The chapters are separete in an a...

  6. Rabotshaja sila, gossudarstvennõi sektor i programma promõshlennogo razvitija / Eteri Kekelidze

    Index Scriptorium Estoniae

    Kekelidze, Eteri, 1944-

    2007-01-01

    Tööandjate Keskliidu juhatuse esimehe Enn Veskimägi arvamusi tööjõust, riiklikust sektorist ja tööstuse arenguprogrammist. Tööandjate keskliidu pöördumisest vabariigi valitsuse poole, milles juhitakse tähelepanu riigi majanduse ees seisvatele probleemidele. Vt. samas: Eesti eksport 2005-2007 esimene pool

  7. The Post-Myocardial Infarction Pacing Remodeling Prevention Therapy (PRomPT) Trial

    DEFF Research Database (Denmark)

    Chung, Eugene S; Fischer, Trent M; Kueffer, Fred

    2015-01-01

    BACKGROUND: Despite considerable improvements in the medical management of patients with myocardial infarction (MI), patients with large MI still have substantial risk of developing heart failure. In the early post-MI setting, implantable cardioverter defibrillators have reduced arrhythmic deaths...

  8. Proměny a konstanty Helfertova psaní o Janáčkovi

    Czech Academy of Sciences Publication Activity Database

    Zapletal, Miloš

    2016-01-01

    Roč. 51, č. 2 (2016), s. 237-271 ISSN 1212-0391 Institutional support: RVO:68378076 Keywords : Helfert * Janáček * reception of music * discourse analysis * music criticism * methodologies of musical historiography * conceptions of history * writing (écriture) Subject RIV: AL - Art, Architecture, Cultural Heritage OBOR OECD: Performing arts studies (Musicology, Theater science, Dramaturgy) https://digilib.phil.muni.cz/bitstream/handle/11222.digilib/136152/1_MusicologicaBrunensia_51-2016-2_22.pdf?sequence=1

  9. Handling big(ger) logs : connecting ProM 6 to Apache Hadoop

    NARCIS (Netherlands)

    Hernández, Sergio; Zelst, van S.J.; Ezpeleta, J.; Aalst, van der W.M.P.; Daniel, F.; Zugal, S.

    2015-01-01

    Within process mining the main goal is to support the analysis, improvement and apprehension of business processes. Numerous process mining techniques have been developed with that purpose. The majority of these techniques use conventional computation models and do not apply novel scalable and

  10. Measurement properties of patient-reported outcome measures (PROMS) in Patellofemoral Pain Syndrome: a systematic review.

    Science.gov (United States)

    Green, Andrew; Liles, Clive; Rushton, Alison; Kyte, Derek G

    2014-12-01

    This systematic review investigated the measurement properties of disease-specific patient-reported outcome measures used in Patellofemoral Pain Syndrome. Two independent reviewers conducted a systematic search of key databases (MEDLINE, EMBASE, AMED, CINHAL+ and the Cochrane Library from inception to August 2013) to identify relevant studies. A third reviewer mediated in the event of disagreement. Methodological quality was evaluated using the validated COSMIN (Consensus-based Standards for the Selection of Health Measurement Instruments) tool. Data synthesis across studies determined the level of evidence for each patient-reported outcome measure. The search strategy returned 2177 citations. Following the eligibility review phase, seven studies, evaluating twelve different patient-reported outcome measures, met inclusion criteria. A 'moderate' level of evidence supported the structural validity of several measures: the Flandry Questionnaire, Anterior Knee Pain Scale, Functional Index Questionnaire, Eng and Pierrynowski Questionnaire and Visual Analogue Scales for 'usual' and 'worst' pain. In addition, there was a 'Limited' level of evidence supporting the test-retest reliability and validity (cross-cultural, hypothesis testing) of the Persian version of the Anterior Knee Pain Scale. Other measurement properties were evaluated with poor methodological quality, and many properties were not evaluated in any of the included papers. Current disease-specific outcome measures for Patellofemoral Pain Syndrome require further investigation. Future studies should evaluate all important measurement properties, utilising an appropriate framework such as COSMIN to guide study design, to facilitate optimal methodological quality. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Proměnlivost druhu Urtica dioica na území ČR

    OpenAIRE

    Rejlová, Ludmila

    2014-01-01

    The genus Urtica L. is represented by three species occurring in the area of the Czech Republic. The most common Urtica dioica L. represents a highly variable group with number of intraspecific taxa. The most common source of variability in Urtica dioica is probably polyploidy (min. 2 ploidy levels - 2x and 4x). Another source of the variation in this species is dioecy. A small percentage of individuals in dioecious populations are actually monoecious. The study of these individuals can poten...

  12. Podoby a proměny strukturální tematiky

    Czech Academy of Sciences Publication Activity Database

    Sládek, Ondřej

    2009-01-01

    Roč. 41, - (2009), s. 41-54 ISSN 0231-5904 Institutional research plan: CEZ:AV0Z90560517 Keywords : structuralism * Vodička, Felix * thematics * Propp, Vladimir Jakovlevič * Lévi-Strauss, Claude * Doležel, Lubomír * Mukařovský, Jan Subject RIV: AJ - Letters, Mass-media, Audiovision

  13. Prom week meets Skyrim: Developing a social agent architecture in a commercial game

    NARCIS (Netherlands)

    Guimarães, Manuel; Santos, Pedro A.; Jhala, Arnav

    2018-01-01

    We present and describe CIF-CK — a social agent architecture that models reasoning about persistent social interactions to improve narrative engagement and play experience for human interactors. The architecture is inspired by McCoy et al’s Comme il-Faut (CiF) architecture that represents rich

  14. Improving Navy Recruiting with the New Planned Resource Optimization Model With Experimental Design (PROM-WED)

    Science.gov (United States)

    2017-03-01

    GUI graphical user interface HumRRO Human Resources Research Organization JPM Job Performance Measurement/Enlistment Standards LRP loan repayment... management system… for all appropriated funding” (Tomasini, n.d.). The DOD’s strategy, force structure, and allocation of resources are all delineated...Alexandria, Va. Human Resources Research Organization. Microsoft Excel, Version 15.0.4849.1003 [Computer software] (2013). Redmond, WA: Microsoft

  15. Horthy a jeho doba – proměny hodnocení

    Czech Academy of Sciences Publication Activity Database

    Irmanová, Eva

    2011-01-01

    Roč. 109, č. 1 (2011), s. 15-43 ISSN 0862-6111 R&D Projects: GA AV ČR IAA800150801 Institutional research plan: CEZ:AV0Z80150510 Keywords : inter-war Hungary * Regent Miklós Horthy * Hungarian historiography Subject RIV: AB - History

  16. The PRoM framework : a new era in process mining tool support

    NARCIS (Netherlands)

    Dongen, van B.F.; Alves De Medeiros, A.K.; Verbeek, H.M.W.; Weijters, A.J.M.M.; Aalst, van der W.M.P.; Ciardo, G.; Darondeau, P.

    2005-01-01

    Under the umbrella of buzzwords such as Business Activity Monitoring (BAM) and Business Process Intelligence (BPI) both academic (e.g., EMiT, Little Thumb, InWoLvE, Process Miner, and MinSoN) and commercial tools (e.g., ARIS PPM, HP BPI, and ILOG JViews) have been developed. The goal of these tools

  17. Profesní ideál sester a jeho proměny

    OpenAIRE

    Juklíčková, Ilona

    2017-01-01

    This thesis deals with the changes in the concept of the ideal characteristics of a nurse in the context of historical development, social changes and other factors. These include mainly an educational reform, new biomedical findings and the influence of the media along with generational differences in nurses. This thesis aims at comparing the ideal characteristics of a nurse as portrayed in professional literature with ideas which nurses have themselves about their own desired professional c...

  18. Individuel survivorship program for ovarian cancer patients based on PROM and shared decision making - PROMova

    DEFF Research Database (Denmark)

    Kargo, Anette Stolberg; Coulter, Angela; Hjøllund, Niels Henrik Ingvar

    follow-up as a means of incorporating patients’ knowledge, needs and preferences to create an individualized follow up program. Materials and methods: Women diagnosed with ovarian cancer who have completed first line treatment and entered follow up are being recruited to the study, including those...... receiving Bevacizumab treatment, and all oncology departments in Denmark have been invited to participate in PROMova. We aim to recruit 300 patients, all of whom will be followed-up for 3 years whether or not they experience a recurrence. Results: Recruitment is in progress with 13 patients recruited...

  19. Should we all go to the PROM? The first two years of the British Spine Registry.

    Science.gov (United States)

    Breakwell, L M; Cole, A A; Birch, N; Heywood, C

    2015-07-01

    The effective capture of outcome measures in the healthcare setting can be traced back to Florence Nightingale's investigation of the in-patient mortality of soldiers wounded in the Crimean war in the 1850s. Only relatively recently has the formalised collection of outcomes data into Registries been recognised as valuable in itself. With the advent of surgeon league tables and a move towards value based health care, individuals are being driven to collect, store and interpret data. Following the success of the National Joint Registry, the British Association of Spine Surgeons instituted the British Spine Registry. Since its launch in 2012, over 650 users representing the whole surgical team have registered and during this time, more than 27 000 patients have been entered onto the database. There has been significant publicity regarding the collection of outcome measures after surgery, including patient-reported scores. Over 12 000 forms have been directly entered by patients themselves, with many more entered by the surgical teams. Questions abound: who should have access to the data produced by the Registry and how should they use it? How should the results be reported and in what forum? ©2015 The British Editorial Society of Bone & Joint Surgery.

  20. Don't Let Drinking and Driving Kill the Pleasure of the Prom.

    Science.gov (United States)

    Zakariya, Sally Banks

    1984-01-01

    This article describes programs successfully combating drunk driving among teenagers in Maine, Virginia, and New York, discusses the nationwide movement called Students Against Driving Drunk (SADD), anti-drunk driving legislation, and the need for increased alcohol education, and provides information on how to emphasize student sobriety and safety…

  1. Otvetshajet Maido Agur, predsedatel profsojuza rabotnikov slantsedobõvajushtshei promõshlennosti / Maido Agur

    Index Scriptorium Estoniae

    Agur, Maido

    2005-01-01

    Majandus- ja kommunikatsiooniministeeriumi plaanist jätkata põlevkivi ostmist Venemaalt. Põlevkivitööstuse töötajate ametiühingute esimehe Maido Aguri sõnul püütakse Venemaa sotsiaalprobleeme lahendada Eesti kaevurite arvelt

  2. Restricted intra-embryonic origin of bona fide hematopoietic stem cells in the chicken

    NARCIS (Netherlands)

    Yvernogeau, Laurent; Robin, Catherine

    2017-01-01

    Hematopoietic stem cells (HSCs), which are responsible for blood cell production, are generated during embryonic development. Human and chicken embryos share features that position the chicken as a reliable and accessible alternative model to study developmental hematopoiesis. However, the existence

  3. 29 CFR 4.171 - “Bona fide” fringe benefits.

    Science.gov (United States)

    2010-07-01

    ... plans or trusts of the types listed in 26 U.S.C. 401(a) which are disapproved by the Internal Revenue Service as not satisfying the requirements of section 401(a) of the Internal Revenue Code or which do not... expenses incident to employment, incentive or suggestion awards, and recruitment bonuses, as well as tools...

  4. 78 FR 25181 - Revision of Regulations Defining Bona Fide Cotton Spot Markets

    Science.gov (United States)

    2013-04-30

    ...;Prices of new books are listed in the first FEDERAL REGISTER issue of each #0;week. #0; #0; #0; #0;#0... amending references to the ``New York Cotton Exchange'' to read the ``Intercontinental Exchange.'' DATES...), AMS has considered the economic impact of this action on small entities and has determined that its...

  5. Using Bona Adaptation to Improve Accent Defects as a Voice Training Method

    Science.gov (United States)

    Aycan, Kivanc

    2017-01-01

    Purpose: In this research, it is observed that if solfeggio syllables, consonants, and vowels are spoken properly, voice intensity (accent), duration, pitch (high pitch-low pitch) and intonation (the ability to carry a musical voice) related to proper pitch level. In this study, it is observed that rhythmic structures do not form without…

  6. 29 CFR 1604.2 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-07-01

    ... narrowly. Label—“Men's jobs” and “Women's jobs”—tend to deny employment opportunities unnecessarily to one... example, the assumption that the turnover rate among women is higher than among men. (ii) The refusal to hire an individual based on stereotyped characterizations of the sexes. Such stereotypes include, for...

  7. IC 3639 - A new bona fide Compton thick AGN unveiled by NuSTAR

    DEFF Research Database (Denmark)

    Boorman, Peter G.; Gandhi, P.; Alexander, D.

    2016-01-01

    We analyse high-quality NuSTAR observations of the local (z = 0.011) Seyfert 2 active galactic nucleus (AGN) IC 3639, in conjunction with archival Suzaku and Chandra data. This provides the first broadband X-ray spectral analysis of the source, spanning nearly two decades in energy (0.5 -30 keV)....

  8. Discriminating strength: a bona fide measure of non-classical correlations

    Science.gov (United States)

    Farace, A.; De Pasquale, A.; Rigovacca, L.; Giovannetti, V.

    2014-07-01

    A new measure of non-classical correlations is introduced and characterized. It tests the ability of using a state ρ of a composite system AB as a probe for a quantum illumination task (e.g. see Lloyd 2008 Science 321 1463), in which one is asked to remotely discriminate between the two following scenarios: (i) either nothing happens to the probe, or (ii) the subsystem A is transformed via a local unitary {{R}_{A}} whose properties are partially unspecified when producing ρ. This new measure can be seen as the discrete version of the recently introduced interferometric power measure (Girolami et al 2013 e-print arXiv:1309.1472) and, at least for the case in which A is a qubit, it is shown to coincide (up to an irrelevant scaling factor) with the local quantum uncertainty measure of Girolami, Tufarelli and Adesso (2013 Phys. Rev. Lett. 110 240402). Analytical expressions are derived which allow us to formally prove that, within the set of separable configurations, the maximum value of our non-classicality measure is achieved over the set of quantum-classical states (i.e. states ρ which admit a statistical unravelling where each element of the associated ensemble is distinguishable via local measures on B).

  9. Discriminating strength: a bona fide measure of non-classical correlations

    Energy Technology Data Exchange (ETDEWEB)

    Farace, A; De Pasquale, A; Giovannetti, V [NEST, Scuola Normale Superiore and Istituto Nanoscienze-CNR, I-56126 Pisa (Italy); Rigovacca, L [Scuola Normale Superiore, I-56126 Pisa (Italy)

    2014-07-01

    A new measure of non-classical correlations is introduced and characterized. It tests the ability of using a state ρ of a composite system AB as a probe for a quantum illumination task (e.g. see Lloyd 2008 Science 321 1463), in which one is asked to remotely discriminate between the two following scenarios: (i) either nothing happens to the probe, or (ii) the subsystem A is transformed via a local unitary R{sub A} whose properties are partially unspecified when producing ρ. This new measure can be seen as the discrete version of the recently introduced interferometric power measure (Girolami et al 2013 e-print arXiv:1309.1472) and, at least for the case in which A is a qubit, it is shown to coincide (up to an irrelevant scaling factor) with the local quantum uncertainty measure of Girolami, Tufarelli and Adesso (2013 Phys. Rev. Lett. 110 240402). Analytical expressions are derived which allow us to formally prove that, within the set of separable configurations, the maximum value of our non-classicality measure is achieved over the set of quantum-classical states (i.e. states ρ which admit a statistical unravelling where each element of the associated ensemble is distinguishable via local measures on B). (paper)

  10. Discriminating strength: a bona fide measure of non-classical correlations

    International Nuclear Information System (INIS)

    Farace, A; De Pasquale, A; Giovannetti, V; Rigovacca, L

    2014-01-01

    A new measure of non-classical correlations is introduced and characterized. It tests the ability of using a state ρ of a composite system AB as a probe for a quantum illumination task (e.g. see Lloyd 2008 Science 321 1463), in which one is asked to remotely discriminate between the two following scenarios: (i) either nothing happens to the probe, or (ii) the subsystem A is transformed via a local unitary R A whose properties are partially unspecified when producing ρ. This new measure can be seen as the discrete version of the recently introduced interferometric power measure (Girolami et al 2013 e-print arXiv:1309.1472) and, at least for the case in which A is a qubit, it is shown to coincide (up to an irrelevant scaling factor) with the local quantum uncertainty measure of Girolami, Tufarelli and Adesso (2013 Phys. Rev. Lett. 110 240402). Analytical expressions are derived which allow us to formally prove that, within the set of separable configurations, the maximum value of our non-classicality measure is achieved over the set of quantum-classical states (i.e. states ρ which admit a statistical unravelling where each element of the associated ensemble is distinguishable via local measures on B). (paper)

  11. The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology

    Science.gov (United States)

    Mallet, François; Bouton, Olivier; Prudhomme, Sarah; Cheynet, Valérie; Oriol, Guy; Bonnaud, Bertrand; Lucotte, Gérard; Duret, Laurent; Mandrand, Bernard

    2004-01-01

    The definitive demonstration of a role for a recently acquired gene is a difficult task, requiring exhaustive genetic investigations and functional analysis. The situation is indeed much more complicated when facing multicopy gene families, because most or portions of the gene are conserved among the hundred copies of the family. This is the case for the ERVWE1 locus of the human endogenous retrovirus W family (HERV-W), which encodes an envelope glycoprotein (syncytin) likely involved in trophoblast differentiation. Here we describe, in 155 individuals, the positional conservation of this locus and the preservation of the envelope ORF. Sequencing of the critical elements of the ERVWE1 provirus showed a striking conservation among the 48 alleles of 24 individuals, including the LTR elements involved in the transcriptional machinery, the splice sites involved in the maturation of subgenomic Env mRNA, and the Env ORF. The functionality and tissue specificity of the 5′ LTR were demonstrated, as well as the fusogenic activity of the envelope polymorphic variants. Such functions were also shown to be preserved in the orthologous loci isolated from chimpanzee, gorilla, orangutan, and gibbon. This functional preservation among humans and during evolution strongly argued for the involvement of this recently acquired retroviral envelope glycoprotein in hominoid placental physiology. PMID:14757826

  12. Improved decay rates for solutions for a multidimensional generalized Benjamin-Bona-Mahony equation

    KAUST Repository

    Said-Houari, Belkacem

    2014-01-01

    the Fourier transform and the energy method, we show the global existence and the convergence rates of the solutions under the smallness assumption on the initial data and we give better decay rates of the solutions. This result improves early works in J

  13. 26 CFR 1.937-1 - Bona fide residency in a possession.

    Science.gov (United States)

    2010-04-01

    ... time during the day. Notwithstanding the preceding sentence, the following days will not count as days... organizations in State C. Z receives mail in State C, including brokerage statements, credit card bills, and...

  14. Muusikamaailm : Gaudeamuse muusikanädal Amsterdamis. The Last Night of the Prom"s. Uusaastakontsert tuleb Uus-Meremaalt. Baieri Riigiooperi orkestri Euroopa reis. Kimanen jääb aastaks eemale Kuhmost / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    1999-01-01

    12. sept. lõppes Amsterdamis Gaudeamuse rahvusvaheline muusikanädal "Surprising New Sounds". Promenaadikontserdid Londoni Royal Albert Hallis (16.07-11.09) lõppesid suure lõppkontserdiga. Traditsioonilise uusaastakontserdi asemel Viinis kantakse sel aastavahetusel üle kontsert Uus-Meremaalt Gisborne"ist. Seoses R. Straussi mälestusaastapäevaga toimus Baieri Riigiooperi orkestri ringreis Euroopas. 30 aastat Kuhmo kammermuusikafestivali juhtinud S. Kimanen võtab aasta puhkust

  15. Proměny vypravěče v próze Jaromíra Johna

    OpenAIRE

    Kleňha, Petr

    2011-01-01

    Metamorphoses of Narrator in Novels of Jaromír John This diploma paper focuses on the function of the narrator and his various forms in John's prosaic work. It deals with the issue of the construction of the fictional world and how the narrator influences the reader's understanding of the described events. Primarily, we try to compare the narrative categories of the main contemporary concepts as influenced by Shlomith Rimmon-Kenan, Franz Stanzel and Lubomír Doležel. It is our terminology base...

  16. Proměny a problémy české sociální politiky

    Czech Academy of Sciences Publication Activity Database

    Večerník, Jiří

    2005-01-01

    Roč. 41, č. 5 (2005), s. 863-880 ISSN 0038-0288 R&D Projects: GA ČR(CZ) GA403/03/0339 Institutional research plan: CEZ:AV0Z70280505 Keywords : Social policy * Czech Republic Subject RIV: AO - Sociology, Demography Impact factor: 0.113, year: 2005

  17. Legenda: podoby a proměny v českém písemnictví

    Czech Academy of Sciences Publication Activity Database

    Rejzlová, Vendula

    2014-01-01

    Roč. 64, č. 3 (2014), s. 116-124 ISSN 0009-0786 Institutional support: RVO:68378068 Keywords : Czech literature * medieval literature * genology * hagiography Subject RIV: AJ - Letters, Mass-media, Audiovision

  18. Effet de l'hymexazole et de la prométhryne sur la qualité physico ...

    African Journals Online (AJOL)

    User

    l'environnement, voire pour la santé de l'homme. Les conséquences toxicologiques dues à l'exposition à ces milliers de composants chimiques par le biais de l'alimentation, de l'eau et du sol sont alarmantes. La plupart des substances actives de ces produits phytosanitaires peuvent former des résidus liés au niveau des ...

  19. Postmoderní proměny v životě i díle Zygmunta Baumana

    Czech Academy of Sciences Publication Activity Database

    Sedláčková, Markéta

    2003-01-01

    Roč. 39, č. 1 (2003), s. 99-104 ISSN 0038-0288 Institutional research plan: CEZ:AV0Z7028912 Keywords : Bauman * postmodernity * ethics Subject RIV: AO - Sociology, Demography Impact factor: 0.063, year: 2003

  20. Prom Night in Mississippi: A Teacher's Guide with Standards-Based Lessons for Grades 7 and up

    Science.gov (United States)

    Holladay, Jennifer

    2009-01-01

    When Morris Dees was a young man in Alabama, the law said that black people couldn't drink from the same water fountain as white people, or sit at the same lunch counter. Back then, the government created and sanctioned divisions between human beings. The Civil Rights Movement changed all of that, of course, and ended state-mandated apartheid in…

  1. 17 CFR 1.47 - Requirements for classification of purchases or sales of contracts for future delivery as bona...

    Science.gov (United States)

    2010-04-01

    ... Management and Budget under control number 3038-0013) [42 FR 42751, Aug. 8, 1977, as amended at 46 FR 63035... and positions for future delivery and the offsetting cash positions; (2) Set forth in detail... of risk exposure attendant to the conduct and management of a commercial enterprise; (3) Contain, and...

  2. Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is a bona fide substrate for Legionelle pneumophila effector glucosyltransferases

    DEFF Research Database (Denmark)

    Tzivelekidis, Tina; Jank, Thomas; Pohl, Corinna

    2011-01-01

    Legionella pneumophila, which is the causative organism of Legionnaires disease, translocates numerous effector proteins into the host cell cytosol by a type IV secretion system during infection. Among the most potent effector proteins of Legionella are glucosyltransferases (Lgt’s), which...

  3. 29 CFR 1627.17 - Calculating the amount of qualified retirement benefits for purposes of the exemption for bona...

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Calculating the amount of qualified retirement benefits for... Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION RECORDS TO BE... age of forced retirement. An employee's accumulated contributions are the sum of all contributions...

  4. És la morfometria geométrica una bona eina per a classificar fèlids?

    OpenAIRE

    De la Cruz Bueno, Sara

    2014-01-01

    La morfometria geomètrica (MG) és una tècnica matemàtica que permet l’estudi de la grandària i de la forma en cossos i peces, biològiques o no. Al basar-se en el tractament digital de la imatge, és molt conservadora, i altament repetible. En aquest treball, es pretén saber si amb la MG es pot classificar fèlids salvatges en base a la morfologia (grandària i forma) del crani. Amb aquest objectiu, es va prendre una mostra de 42 cranis adults de diversos gèneres pertanyents a la família Felidae,...

  5. Bona fide colour: DNA prediction of human eye and hair colour from ancient and contemporary skeletal remains

    NARCIS (Netherlands)

    J. Draus-Barini (Jolanta); S. Walsh (Susan); E. Pośpiech (Ewelina); T. Kupiec (Tomasz); H. Głab (Henryk); W. Branicki (Wojciech); M.H. Kayser (Manfred)

    2013-01-01

    textabstractBackground: DNA analysis of ancient skeletal remains is invaluable in evolutionary biology for exploring the history of species, including humans. Contemporary human bones and teeth, however, are relevant in forensic DNA analyses that deal with the identification of perpetrators, missing

  6. Televizní lifestylové pořady : fenomén maskulinity, proměny a úspěchu

    OpenAIRE

    Horáčková, Lucie

    2010-01-01

    Diploma thesis "TV Lifestyle Magazines : Phenomenon of Masculinity, Makeover and Success" mostly deals with the concepts of life-style, taste, makeover a masculinity and their factual manifestation in particular television shows. In its theoretical part the thesis defines fundamental themes and concepts based on literature, especially according to Pierre Bourdieu, Dick Hebdige and Michel Foucault. The concept of life-style has gained much importance in contemporary society, because it's actua...

  7. Větrná energie, člověk a krajina v proměnách času

    Czech Academy of Sciences Publication Activity Database

    Kallabová, Eva; Frantál, Bohumil; Nováková, Eva

    2009-01-01

    Roč. 35, č. 1 (2009), s. 379-396 ISSN 0323-0988 R&D Projects: GA AV ČR(CZ) KJB700860801 Institutional research plan: CEZ:AV0Z30860518 Keywords : wind * regionalization * wind power plants * local identity * Czech republic * wind energy Subject RIV: DE - Earth Magnetism, Geodesy, Geography

  8. Proměny restaurování keramických nálezů v čase

    Czech Academy of Sciences Publication Activity Database

    Svobodová, Ljuba; Kloužková, A.

    2016-01-01

    Roč. 2016, - (2016), s. 110-115 ISSN 1805-0050 R&D Projects: GA ČR GP13-34374P Institutional support: RVO:67985912 Keywords : restoration * ceramics * Prague Castle Subject RIV: AC - Archeology, Anthropology, Ethnology

  9. Dictionary of the gas industry. Dictionnaire de l'industrie du gaz; Fachwoerterbuch der Gasindustrie; Slovar'po gazovo prom'shlennosti

    Energy Technology Data Exchange (ETDEWEB)

    1982-01-01

    The new English, French, German, and Russian Dictionary of the Gas Industry is the only comprehensive dictionary for this important field of engineering. More than 6,000 terms, numerous definitions and 11 appendices cover the entire range of the industry's operations from reservoir engineering to appliance manufacture and from the properties of coal used for gas production to the wide variety of tariffs and rates at which gas is sold to users. The Dictionary has been edited by a committee of linguists and engineers set up by the International Gas Union.

  10. Proměny hodnotových orientací a sebehodnocení obyvatel Hlučínska a České republiky

    Directory of Open Access Journals (Sweden)

    František Znebejánek

    2017-01-01

    Full Text Available The study is trying to contribute to the knowledge of the development and behaviour of the inhabitants of buffer zones. It is based on the historical development of the Hlučinsko region and the Czechoslovakia, later the Czech Republic. A set of questions is formulated based on the developmental differences between the two territories. A survey was carried out in 2014 of 604 respondents of the Hlučinsko region and 1000 respondents of the entire Czech Republic. From the point of view of value orientation, the results of the survey show Hlučinsko region inhabitants to be still different from those of the entire Czech Republic, without, however, showing substantial differences between the two youngest age cohorts. It is the middle age cohort that plays the key role in the changes of value orientation. In the Hlučinsko region, changes in value orientation are mainly due to the increasing role of education. Self assessment of the Hlučinsko region inhabitants combines traditionalism and openness to change. It may be a consequence of their ability to adapt to the pressure of the administration of the respective state to which they belonged. On the basis of the data obtained, it can be concluded that the youngest age cohort of Hlučinsko region inhabitants is already integrated into Czech society.

  11. Muzeum umění v proměnách své sociální funkce

    OpenAIRE

    Černá, Lucie

    2014-01-01

    Art museums still have an essential role, both for the art world and the wider society. This thesis deals mainly with their transformation and challenges they have to face in relation to contemporary society. It focuses on the development of museums, the transformation of values they embody and also on changes in normative expectations in conjunction with them. The paper also discusses the role of museums with increasing emphasis on their educational role, because this role could help museums...

  12. Proměna vzdělávání učitelů chemie v České republice

    OpenAIRE

    Čerňanská, Božena

    2011-01-01

    Title: Transforming teacher education of chemistry in the Czech Republic Abstract: The title of the dissertation is 'Transforming teacher education of chemistry in the Czech Republic'. The work describes and analyzes the current system of the pregraduate prospective teachers' training of chemistry at universities and faculties of science focused on teaching science as well the subsequent in-service education of chemistry teachers in this country. The work also takes into account the post-war ...

  13. Comment choisir ce qui aura été? Réflexions sur l’optimisme prométhéen contemporain

    Directory of Open Access Journals (Sweden)

    Alexander Wilson

    2015-12-01

    Full Text Available Many have invoked the nihilism that is endemic of the age we call the anthropocene. Bernard Stiegler has articulated this sentiment by highlighting how anthropocene films are typically nihi listic, for example, Von Trier’s Melancholia. But if the age is characterized by a cultural pessi mism about the future of human kind, or again about its posthuman supersession, there is also a complementary symptom that corresponds to a strange optimism before the impasses of our age. This optimism, we find it represented in another anthropocene film: Nolan’s Interstellar. This too is a film where the protagonists are faced with a world lacking a future, a world dying under the stresses caused by the human’s exploitation of nature. Here, instead of the mantra ‘Enjoy it while it lasts’, an opposing moral is repeated: ‘Don’t go gentle into that good night, Rage, rage against the dying of the light.’ In the film, Thomas’ poem is a tribute to prometheanism; the death of the earth will not mean the end of human life, it declares, the human will surpass all the limits of its ecosystem, the constraints of space time itself, and become pure hyperdimensional intelligence. The film echoes the superstitious optimism in the promise of technology we now find at the heart of contemporary movements such as accelerationism. This paper assesses the validity of this intrumentalization of optimism, drawing from Leibniz’s concept of compossibility and the cosmological anthropic principle (observer bias.

  14. Proměny profesních kompetencí učitelky MŠ v souvislosti s věkem a praxí

    OpenAIRE

    ŠEJVAROVÁ, Zdeňka

    2012-01-01

    The question of structure and importance of professional competencies of teachers has been addressed by a number of pedagogues. The matter has been approached from different perspectives and numerous models were generated. Though a uniform definition has not been reached so far, in essence, all the models express the same fact: the preparedness and readiness of teachers for their profession. The aim of the thesis is to point out the possibility of changes in the perception of professional com...

  15. Obraz druhého: příklady z francouzských dějin (kontext a proměny

    Directory of Open Access Journals (Sweden)

    Pavel Sitek

    2010-12-01

    Full Text Available Following text deals with the problems of relationships between the French society and “the other”. The emphasis is put on the context and discourses of political elites during the 19th and 20th century that influenced the creations and the transformations of structured representations not only of “the other” but also of “itself”. “The other” was connected to different menaces and anxiety about “(national identity”, with a cultural and social thread. In this article we propose three examples to demonstrate that perception of “the other” changes during the time in dependence on the context.

  16. Proměny v produkci a recepci řeči v pozdním věku

    Czech Academy of Sciences Publication Activity Database

    Müllerová, Olga

    2007-01-01

    Roč. 16, - (2007), s. 107-115 ISSN 1230-2287 R&D Projects: GA ČR GA405/03/0133; GA ČR GA405/06/1468 Institutional research plan: CEZ:AV0Z90610518 Keywords : communication * production of speech * reception of speech * pronunciation * intonation Subject RIV: AI - Linguistics

  17. O proměnách interpretace občanství EU v judikatuře Evropského soudního dvora

    Czech Academy of Sciences Publication Activity Database

    Hamerník, Pavel

    2007-01-01

    Roč. 16, č. 1 (2007), s. 3-9 ISSN 1802-3843 R&D Projects: GA ČR GA407/06/1467 Institutional research plan: CEZ:AV0Z70680506 Keywords : European Court of Justice * European Union Subject RIV: AG - Legal Sciences

  18. Most do budoucnosti. Příběh města na severu Čech jako studie proměn socialistické modernity

    Czech Academy of Sciences Publication Activity Database

    Spurný, Matěj

    2015-01-01

    Roč. 22, 1/2 (2015), s. 30-79 ISSN 1210-7050 R&D Projects: GA ČR GPP410/12/P596 Institutional support: RVO:68378114 Keywords : Czechoslovakia * communist dictatorship * modernity Subject RIV: AB - History

  19. "FATCA" a její promítnutí do právního řádu České republiky

    OpenAIRE

    Vardanová, Magda

    2015-01-01

    Resume in English Name of the thesis: "FATCA" and its projection into the Czech legal system Foreign Account Tax Compliance Act (alias FATCA), the law of the United States, is currently being much discussed topic not even in the Czech Republic, but within the European Union and also globally, as many developed countries are forced to implement its ideas due to their fear of possible sanctions from the USA. The purpose of this act is more efficient fight against the tax evasion of American tax...

  20. Kombinace elektronové litografie s gaussovským svazkem a s proměnným tvarovaným svazkem

    Czech Academy of Sciences Publication Activity Database

    Krátký, Stanislav; Urbánek, Michal; Chlumská, Jana; Matějka, Milan; Meluzín, Petr; Kolařík, Vladimír; Horáček, Miroslav

    2015-01-01

    Roč. 60, č. 1 (2015), s. 10-13 ISSN 0447-6441 R&D Projects: GA MŠk(CZ) LO1212 Institutional support: RVO:68081731 Keywords : e-beam writer * Gausssian beam * variable shaped beam Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

  1. Proměny vztahů ruské pravoslavné církve a státu v době patriarchy Kirilla

    Directory of Open Access Journals (Sweden)

    Maria Avanesova

    2016-04-01

    Full Text Available This paper is devoted to the topic of relations between the Russian state, Russian society, and the Orthodox Church after the year 2008, when Patriarch Kirill was elected head of the Church. Such relations in Russia have gone through a significant transformation since the beginning of the Post-Soviet period. In the era of Patriarch Alexy II, the Church gradually began to claim a larger political role, the culmination of which was marked by Kirill’s election. At present, the Russian Orthodox Church operates to a certain degree as an institution of Russian political power. Its representatives, led by Kirill, often play a role that is more political than religious. By drawing from primary sources, official documents, media reports, and also speeches made by religious and political representatives, this article attempts to highlight the main issues and areas of cooperation between the state and the Church (e.g. the education system, elections in 2011 and 2012 and explain the ways in which this alliance is advantageous for both parties in relation to the Russian public. The last part of the article deals with how this connection between church and state is perceived by various sections of the Russian public, which is illustrated using several examples from previous years, e.g. the scandal surrounding the members of the feminist punk rock protest group Pussy Riot.

  2. Etnologický výzkum města Brna. Stabilita a proměny moravské metropole

    Czech Academy of Sciences Publication Activity Database

    Pospíšilová, Jana

    -, - (2009), s. 41-42. ISBN 978-86-7587-054-8. [Terenska istraživanja. 31.08.2009-03.09.2009, Sirogojno] Institutional research plan: CEZ:AV0Z90580513 Keywords : urban ethnology * Brno * tradition * transformation * ethnic situation Subject RIV: AC - Archeology, Anthropology, Ethnology

  3. From the Dress-Up Corner to the Senior Prom: Navigating Gender and Sexuality Diversity in PreK-12 Schools

    Science.gov (United States)

    Bryan, Jennifer

    2012-01-01

    Very few PreK-12 teachers are adequately trained to address the gender identity and sexual identity of their students in a developmentally-appropriate and pedagogically-sound manner. Yet responsible adults--parents, educators, pre-service teachers, coaches, religious instructors, camp administrators and school counselors--must help children…

  4. Proměny politické komunikace v České republice v posledních 20-ti letech

    Czech Academy of Sciences Publication Activity Database

    Mansfeldová, Zdenka; Hronešová, J.

    2011-01-01

    Roč. 9, č. 10 (2011), s. 2-3 ISSN 1214-1720 Grant - others:Evropská komise(XE) CIT4-CT-2006-028698 Institutional research plan: CEZ:AV0Z70280505 Keywords : media * Europe * integration Subject RIV: AD - Politology ; Political Sciences http://www.socioweb.cz/upl/editorial/download/194_SOCIOWEB_10_2011.pdf

  5. Konkrétná logika - ideové vlivy a proměny v souvislosti s vývojem Masarykovy filosofie

    Czech Academy of Sciences Publication Activity Database

    Svoboda, Jan

    2015-01-01

    Roč. 63, č. 1 (2015), s. 17-29 ISSN 0015-1831 Institutional support: RVO:67985955 Keywords : Masaryk's realism * clasification and system of science * scientific metaphysics * sense and value Subject RIV: AA - Philosophy ; Religion

  6. Naše nivy v proměnách času. II. Osud niv v dnešní době

    Czech Academy of Sciences Publication Activity Database

    Ložek, Vojen

    2003-01-01

    Roč. 58, č. 5 (2003), s. 131-136 ISSN 1210-258X Institutional research plan: CEZ:AV0Z3013912 Keywords : processes affecting the floodplains * soil erosion * water nills Subject RIV: DB - Geology ; Mineralogy http://www.casopis.ochranaprirody.cz/res/data/003/000510.pdf

  7. Čtyři nové proměnné hvězdy v Kasiopei objevené pomocí DSLR

    Czech Academy of Sciences Publication Activity Database

    Pintr, Pavel; Vápenka, David; Mašek, M.

    2017-01-01

    Roč. 62, č. 1 (2017), s. 22-25 ISSN 0447-6441 R&D Projects: GA MŠk(CZ) LO1206 Institutional support: RVO:61389021 Keywords : variable stars * light curve * HALZ telescope * period analysis Subject RIV: BH - Optics, Masers, Lasers OBOR OECD: Optics (including laser optics and quantum optics)

  8. Proměny japonského personálního managementu v čase a prostoru

    OpenAIRE

    Zvědělíková, Mirka

    2013-01-01

    The subject of this work is to assess the evolvement of Japanese Human Resource Management mainly from the last decade of the 20th century, the time of the economic crisis in Japan, until present times. The different style of Japanese HRM is considered to be one of the reasons behind the success of Japanese firms on the international markets in the latter half of the 20th century. After 40 years of continuous growth the adaptation to the new worsening conditions was inevitable, which is a sit...

  9. Proměny organizační struktury Ústavu pro jazyk český (1946-1989)

    Czech Academy of Sciences Publication Activity Database

    Dvořáčková, Věra

    2011-01-01

    Roč. 3, č. 1 (2011), s. 37-52 ISSN 1803-9448 Institutional research plan: CEZ:AV0Z90610521 Keywords : The Institute of the Czech Language, organisational structure * organisational structure * Czechoslovak Academy of Sciences Subject RIV: AI - Linguistics

  10. Proměny časování a způsobu návratu matek do zaměstnání

    Czech Academy of Sciences Publication Activity Database

    Hašková, Hana

    2011-01-01

    Roč. 12, č. 2 (2011), s. 40-52 ISSN 1213-0028 R&D Projects: GA ČR GAP404/10/0021 Institutional research plan: CEZ:AV0Z70280505 Keywords : capabilities for work - life balance * refamilization Subject RIV: AO - Sociology, Demography www.genderonline.cz

  11. O původu a zdrojích proměn české podnikatelské elity

    Czech Academy of Sciences Publication Activity Database

    Benáček, Vladimír

    2008-01-01

    Roč. 10, č. 1 (2008), s. 70-89 ISSN 1212-8112 R&D Projects: GA AV ČR(CZ) IAA700280803 Institutional research plan: CEZ:AV0Z70280505 Keywords : entrepreneurship * efficiency * capital Subject RIV: AO - Sociology, Demography

  12. TAF9b (Formerly TAF9L) Is a Bona Fide TAF That Has Unique and Overlapping Roles with TAF9

    OpenAIRE

    Frontini, Mattia; Soutoglou, Evi; Argentini, Manuela; Bole-Feysot, Christine; Jost, Bernard; Scheer, Elisabeth; Tora, Làszlò

    2005-01-01

    TFIID plays a key role in transcription initiation of RNA polymerase II preinitiation complex assembly. TFIID is comprised of the TATA box binding protein (TBP) and 14 TBP-associated factors (TAFs). A second set of transcriptional regulatory multiprotein complexes containing TAFs has been described (called SAGA, TFTC, STAGA, and PCAF/GCN5). Using matrix-assisted laser desorption ionization mass spectrometry, we identified a novel TFTC subunit, human TAF9Like, encoded by a TAF9 paralogue gene....

  13. Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling

    International Nuclear Information System (INIS)

    Noda, Saori; Takahashi, Atsushi; Hayashi, Takeru; Tanuma, Sei-ichi; Hatakeyama, Masanori

    2016-01-01

    SHP2, encoded by the PTPN11 gene, is a protein tyrosine phosphatase that plays a key role in the proliferation of cells via RAS-ERK activation. SHP2 also promotes Wnt signaling by dephosphorylating parafibromin. Germline missense mutations of PTPN11 are found in more than half of patients with Noonan syndrome (NS) and LEOPARD syndrome (LS), both of which are congenital developmental disorders with multiple common symptoms. However, whereas NS-associated PTPN11 mutations give rise to gain-of-function SHP2 mutants, LS-associated SHP2 mutants are reportedly loss-of-function mutants. To determine the phosphatase activity of LS-associated SHP2 more appropriately, we performed an in vitro phosphatase assay using tyrosine-phosphorylated parafibromin, a biologically relevant substrate of SHP2 and the positive regulator of Wnt signaling that is activated through SHP2-mediated dephosphorylation. We found that LS-associated SHP2 mutants (Y279C, T468M, Q506P, and Q510E) exhibited a substantially reduced phosphatase activity toward parafibromin when compared with wild-type SHP2. Furthermore, each of the LS-associated mutants displayed a differential degree of decrease in phosphatase activity. Deviation of the SHP2 catalytic activity from a certain range, either too strong or too weak, may therefore lead to similar clinical outcomes in NS and LS, possibly through an imbalanced Wnt signal caused by inadequate dephosphorylation of parafibromin. - Highlights: • LS-associated SHP2 mutants dephosphorylate parafibromin on Y290, Y293, and Y315. • LS-associated SHP2 mutants display a reduced tyrosine phosphatase activity. • LS-specific SHP2-Y279C is catalytically less active than LS-specific SHP2-T468M. • NS/LS-associated SHP2-Q506P has both hyper- and hypomorphic enzymatic properties.

  14. Epinotia cinereana (Haworth, 1811) bona sp., a Holarctic tortricid distinct from E. nisella (Clerck, 1759) (Lepidoptera: Tortricidae: Eucosmini) as evidenced by DNA barcodes, morphology and life history

    DEFF Research Database (Denmark)

    Mutanen, Marko; Aarvik, Leif; Landry, Jean-Francois

    2012-01-01

    DNA barcodes of European tortricid moths identified as Epinotia nisella (Clerck, 1759) were found to comprise two genetically distinct clusters. These coincided with E. nisella and E. cinereana (Haworth, 1811) (sp. rev.), the latter having been considered a synonym of the former for several decades....... Comparing these DNA barcodes with those of North American Epinotia showed that both species are Holarctic. The North American Proteopteryx criddleana Kearfott, 1907 is a new junior synonym of E. cinereana (syn. nov.). The two species also show distinct differences in male and female genitalia. North...... American populations of both species show moderate differences in barcodes from their respective European populations but there are no morphological differences correlated with the intraspecific barcode clusters. Tortrix petrana Hübner, 1813 is considered as a junior synonym of E. cinereana (syn. rev...

  15. A bona fide two-dimensional percolation model: an insight into the optimum photoactivator concentration in La2/3-xEuxTa2O7 nanosheets

    Directory of Open Access Journals (Sweden)

    Tadashi C Ozawa, Katsutoshi Fukuda, Yasuo Ebina, Kosuke Kosuda, Akira Sato, Yuichi Michiue, Keiji Kurashima and Takayoshi Sasaki

    2011-01-01

    Full Text Available La–Eu solid solution nanosheets La2/3−xEuxTa2O7 have been synthesized, and their photoluminescence properties have been investigated. La2/3−xEuxTa2O7 nanosheets were prepared from layered perovskite compounds Li2La2/3−xEuxTa2O7 as the precursors by soft chemical exfoliation reactions. Both the precursors and the exfoliated nanosheets exhibit a decrease in intralayer lattice parameters as the Eu contents increase. However, there is a discontinuity in this trend between the nominal Eu content ranges x≤ 0.3 and x ≥ 0.4. This discontinuity is attributed to the difference in degree of TaO6 octahedra tilting for the La- and Eu-rich phases. La2/3−xEuxTa2O7 nanosheets exhibit red emission, characteristic of the f–f transitions in Eu3+ photoactivators. The photoluminescence emission can be obtained from both host and direct photoactivator excitation. However, photoluminescence emission through host excitation is much more dominant than that through direct photoactivator excitation, and this behavior is consistent with that of all the other rare-earth photoactivated nanosheets reported previously. The absolute photoluminescence quantum efficiency of the La2/3−xEuxTa2O7 nanosheets increases as the experimentally determined Eu contents increase up to x=0.45 and decrease above it. This result is in good agreement with the optimum photoactivator concentration expected from the percolation theory. These solid solution La2/3−xEuxTa2O7 nanosheets are excellent models for validating the theory of optimum photoactivator concentration in the truly two-dimensional photoactivator matrix.

  16. Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling

    Energy Technology Data Exchange (ETDEWEB)

    Noda, Saori [Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo (Japan); Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba (Japan); Takahashi, Atsushi; Hayashi, Takeru [Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo (Japan); Tanuma, Sei-ichi [Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba (Japan); Hatakeyama, Masanori, E-mail: mhata@m.u-tokyo.ac.jp [Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo (Japan)

    2016-01-22

    SHP2, encoded by the PTPN11 gene, is a protein tyrosine phosphatase that plays a key role in the proliferation of cells via RAS-ERK activation. SHP2 also promotes Wnt signaling by dephosphorylating parafibromin. Germline missense mutations of PTPN11 are found in more than half of patients with Noonan syndrome (NS) and LEOPARD syndrome (LS), both of which are congenital developmental disorders with multiple common symptoms. However, whereas NS-associated PTPN11 mutations give rise to gain-of-function SHP2 mutants, LS-associated SHP2 mutants are reportedly loss-of-function mutants. To determine the phosphatase activity of LS-associated SHP2 more appropriately, we performed an in vitro phosphatase assay using tyrosine-phosphorylated parafibromin, a biologically relevant substrate of SHP2 and the positive regulator of Wnt signaling that is activated through SHP2-mediated dephosphorylation. We found that LS-associated SHP2 mutants (Y279C, T468M, Q506P, and Q510E) exhibited a substantially reduced phosphatase activity toward parafibromin when compared with wild-type SHP2. Furthermore, each of the LS-associated mutants displayed a differential degree of decrease in phosphatase activity. Deviation of the SHP2 catalytic activity from a certain range, either too strong or too weak, may therefore lead to similar clinical outcomes in NS and LS, possibly through an imbalanced Wnt signal caused by inadequate dephosphorylation of parafibromin. - Highlights: • LS-associated SHP2 mutants dephosphorylate parafibromin on Y290, Y293, and Y315. • LS-associated SHP2 mutants display a reduced tyrosine phosphatase activity. • LS-specific SHP2-Y279C is catalytically less active than LS-specific SHP2-T468M. • NS/LS-associated SHP2-Q506P has both hyper- and hypomorphic enzymatic properties.

  17. Cellular repressor of E1A-stimulated genes is a bona fide lysosomal protein which undergoes proteolytic maturation during its biosynthesis

    International Nuclear Information System (INIS)

    Schaehs, Philipp; Weidinger, Petra; Probst, Olivia C.; Svoboda, Barbara; Stadlmann, Johannes; Beug, Hartmut; Waerner, Thomas; Mach, Lukas

    2008-01-01

    Cellular repressor of E1A-stimulated genes (CREG) has been reported to be a secretory glycoprotein implicated in cellular growth and differentiation. We now show that CREG is predominantly localized within intracellular compartments. Intracellular CREG was found to lack an N-terminal peptide present in the secreted form of the protein. In contrast to normal cells, CREG is largely secreted by fibroblasts missing both mannose 6-phosphate receptors. This is not observed in cells lacking only one of them. Mass spectrometric analysis of recombinant CREG revealed that the protein contains phosphorylated oligosaccharides at either of its two N-glycosylation sites. Cellular CREG was found to cosediment with lysosomal markers upon subcellular fractionation by density-gradient centrifugation. In fibroblasts expressing a CREG-GFP fusion construct, the heterologous protein was detected in compartments containing lysosomal proteins. Immunolocalization of endogenous CREG confirmed that intracellular CREG is localized in lysosomes. Proteolytic processing of intracellular CREG involves the action of lysosomal cysteine proteinases. These results establish that CREG is a lysosomal protein that undergoes proteolytic maturation in the course of its biosynthesis, carries the mannose 6-phosphate recognition marker and depends on the interaction with mannose 6-phosphate receptors for efficient delivery to lysosomes

  18. Translating patient reported outcome measures: methodological issues explored using cognitive interviewing with three rheumatoid arthritis measures in six European languages

    NARCIS (Netherlands)

    Hewlett, Sarah E.; Nicklin, Joanna; Bode, Christina; Carmona, Loretto; Dures, Emma; Engelbrecht, Matthias; Hagel, Sofia; Kirwan, John R.; Molto, Anna; Redondo, Marta; Gossec, Laure

    2016-01-01

    Objective. Cross-cultural translation of patient-reported outcome measures (PROMs) is a lengthy process, often performed professionally. Cognitive interviewing assesses patient comprehension of PROMs. The objective was to evaluate the usefulness of cognitive interviewing to assess translations and

  19. Vzhůru do ciziny...!! Rámce a proměny českého cestovního ruchu a cestování do zahraničí po roce 1989

    Czech Academy of Sciences Publication Activity Database

    Mücke, Pavel

    2016-01-01

    Roč. 23, č. 4 (2016), s. 602-644 ISSN 1210-7050 R&D Projects: GA ČR GA15-08130S Institutional support: RVO:68378114 Keywords : post-communism * travelling * tourism * social transformation * economic transformation Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  20. „Kánon“ v českém hudebním dějepisectví a hudební praxi: vznik, funkce a proměny v průběhu let

    Czech Academy of Sciences Publication Activity Database

    Gabrielová, Jarmila

    2013-01-01

    Roč. 39, č. 4 (2013), s. 331-339 ISSN 1335-2458 Institutional support: RVO:68378076 Keywords : historiography * musicology * Czech music culture Subject RIV: AL - Art, Architecture, Cultural Heritage

  1. Od zabijáka k lúzrovi. Literární postava jako vyjádření proměny ve vztahu jedince a bytí // From hired killer to loser

    Directory of Open Access Journals (Sweden)

    Lada Hazaiová

    2015-10-01

    Full Text Available The face of the Colombian literature in the last twenty years has changed and next to the poetics of magical realism new discourses emerged expresing the changing social, cultural and ideological values. One of them represents Fernando Vallejo’s novel Our Lady of Assassins. Another contemporary discourse represents other Colombian writer Sergio Álvarez whose novel 35 dead was published in 2011 in Bogotá, respectively almost 20 years later. He works very similar issues as Vallejo, like urban violence, drug cartels and hired killers, but he also has given life to a special protagonist, called “loser“. The aim of this paper is to compare general features of both protagonists and to suggest that in loser a new type of protagonist has appeared, and not only in the Colombian literature.

  2. "Výslech svědků" jako technika dekompozice masternarativu. Mýtus Moravského pole a jeho proměna v historické naraci Oldřicha Daňka

    Czech Academy of Sciences Publication Activity Database

    Řezníková, Lenka

    2011-01-01

    Roč. 1, č. 1 (2011), s. 82-91 ISSN 0231-634X Institutional research plan: CEZ:AV0Z90090514 Keywords : myth * Roland Barthes * Oldřich Daněk * metahistory * loyalty * the Battle of the Moravian field Subject RIV: AA - Philosophy ; Religion

  3. Proaktivní zvládání u osob staršího věku: vztah k vybraným kognitivním proměnným

    Czech Academy of Sciences Publication Activity Database

    Lukavský, Jiří; Šolcová, Iva; Preiss, M.

    2011-01-01

    Roč. 55, č. 3 (2011), s. 193-203 ISSN 0009-062X Institutional research plan: CEZ:AV0Z7025918 Keywords : proactive coping * ageing * cognitive performance Subject RIV: AN - Psychology Impact factor: 0.087, year: 2011 http://web.ebscohost.com/ehost/pdfviewer/pdfviewer?sid=33c14ac5-c300-43cb-8760-cf3e2c6962a9%40sessionmgr14&vid=5&hid=25

  4. Proměny vypravěče v literatuře a ve filmu: Stendhalův Červený a černý a jeho adaptace

    OpenAIRE

    Chytilová, Vladimíra

    2008-01-01

    This work focuses on the transformations to which is submitted the literary narrator when a literary work is adapted for the screen. The object of study is the novel Le Rouge et le Noir by Stendhal and its two adaptations, a film by Claude Autant-Lara from 1954 and a television miniseries made by Jean-Daniel Verhaeghe in 1997. The first part of the work summarizes the theoretical concepts of four authors who deal with the narrator: two of them, Tzvetan Todorov and Gérard Genette, are literary...

  5. Časopis jako dokument doby. Proměna grafického zpracování obálky časopisu Host do domu (1954-1970)

    Czech Academy of Sciences Publication Activity Database

    Svobodová, Barbora

    2014-01-01

    Roč. 63, 1-2 (2014), s. 66-85 ISSN 1211-7390 Institutional support: RVO:68378068 Keywords : Host do domu (A Guest in the House) * visual culture 50s and 60s * literary magazines * graphic design * magazine cover * 20th century Subject RIV: AJ - Letters, Mass-media, Audiovision

  6. Karel Chotek a Cerovo: od iniciace k specializaci (causerie k půlstoleté proměně terénního výzkumu

    Directory of Open Access Journals (Sweden)

    Milan Ducháček

    2018-04-01

    Full Text Available This paper is about the monograph on the Slovak village Cerovo, published in 1906 by Karel Chotek, the first professor of ethnography at the Comenius University in Bratislava and the pioneer of qualitative field research in the Austro-Hungarian monarchy and later in Czechoslovakia. Following Lubor Niederle’s demographical data published in the map of the Slovak community living in Hungary, Cerovo, a village in the Hont region, shows Chotek’s first attempt to cover the set of questions related to the monograph’s focus on people in their cultural setting via field research and direct experience. Though still partly immersed in stereotypes related to Czech utilitarian conceptualisation of Slovak collective identity, Chotek’s monograph shows the first step on the way to an ambitious serial (though mostly unfulfilled project of regional monographs, known as Národopis lidu českoslovanského (The Ethnography of Czechoslavic People, 1918–1940. In the early 1950s, working already as a professor of Slavic and general ethnography at the Charles University in Prague since 1931, Chotek returned to Cerovo with an idea of a new, comparative and reconceptualised focus on the same settlement as a half century before. Even though he did not succeed in completing this new monograph, his experience inspired a number of students at the Charles University, who later pursued Chotek’s field research inspiration as important figures of Czech and Slovak ethnography during the rest of the 20 th century (the so-called “Chotek school”. Besides rethinking the events related to the Czecho-Slovak relationship in the formative decade of professional scientific ethnography in Czech lands before World War I and, last but not least, analysing the so far unknown context of Chotek’s second expedition to Cerovo in 1953, the picture of Chotek developing his field research method from a descriptive analysis to a more structured circle of special questions/issues in the 1950s is an attempt to capture some of the methodological changes Czechoslovak ethnography went through during the first half of the 20 th century.

  7. Karel Chotek a Cerovo: od iniciace k specializaci (causerie k půlstoleté proměně terénního výzkumu)

    OpenAIRE

    Milan Ducháček

    2018-01-01

    This paper is about the monograph on the Slovak village Cerovo, published in 1906 by Karel Chotek, the first professor of ethnography at the Comenius University in Bratislava and the pioneer of qualitative field research in the Austro-Hungarian monarchy and later in Czechoslovakia. Following Lubor Niederle’s demographical data published in the map of the Slovak community living in Hungary, Cerovo, a village in the Hont region, shows Chotek’s first attempt to cover the set of questions related...

  8. Frazeologie a idiomatika: Jejich podstata a proměnlivost názorů na ně : Phraseology and Idiomatics: Their Essence and the Changing Views on the Subject

    Directory of Open Access Journals (Sweden)

    František Čermák

    2016-05-01

    Full Text Available The paper addresses most of the current problems in phraseology. General observations on the universal character of idioms and the major aspects of the topic are followed by critical analysis of a prototypical statement about the essential nature of idioms. Much of the analysis centres around the notions of analogy and anomaly. The paper considers the form of the idiom, its analysability, modifiability and metaphoric character, and then challenges the current views on these. Next, the discussion of the idiom and its meaning returns to metaphor and hypothetical decomposition and briefly summarises some of the semantic features of idioms. It suggests that the function of idioms, and the issues of their form and meaning, are best revealed through the character and type of their textual anomalies. The author then presents his views on idioms and their study, referring to analogy and anomaly, regular and irregular language and especially language combinatorics. His approach was tested on data collected for a comprehensive four-volume dictionary of Czech idioms. The paper describes types of combinations and the crucial notions of collocational and virtual paradigms. It offers and exemplifies definitions of idioms and a test for the identification of idioms in text, and a desideratum for further testing of the proposed theory.

  9. Časová proměnlivost horkých vln v České republice a extrémní horká vlna z roku 1994

    Czech Academy of Sciences Publication Activity Database

    Kyselý, Jan

    2003-01-01

    Roč. 56, - (2003), s. 13-19 ISSN 0026-1173 R&D Projects: GA ČR GP205/01/D040 Institutional research plan: CEZ:AV0Z3042911 Keywords : heat wave * temporal variability * Czech Republic * mortality Subject RIV: DG - Athmosphere Sciences, Meteorology

  10. Syndrom vyhoření, vybrané psychologické proměnné a rizikové faktory kardiovaskulárních onemocnění

    Czech Academy of Sciences Publication Activity Database

    Kebza, V.; Šolcová, Iva

    2010-01-01

    Roč. 54, č. 1 (2010), s. 1-16 ISSN 0009-062X R&D Projects: GA ČR GA406/06/0747 Institutional research plan: CEZ:AV0Z70250504 Keywords : burnout * cardiovascular disease * lipid metabolism Subject RIV: AN - Psychology Impact factor: 0.230, year: 2010

  11. Objev nové ELL proměnné hvězdy v souhvězdí Kentaura a možnost detekce nových exoplanet pomocí dalekohledu FRAM

    Czech Academy of Sciences Publication Activity Database

    Pintr, Pavel; Vápenka, David; Mašek, M.

    2015-01-01

    Roč. 60, č. 2 (2015), s. 65-68 ISSN 0447-6441 R&D Projects: GA MŠk(CZ) LO1206; GA ČR GA13-10365S Institutional support: RVO:61389021 Keywords : variable star * light curve * FRAM * period analysis * exoplanet transit Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics http://jmo.fzu.cz/

  12. A cluster randomised controlled trial of a staff-training intervention in residential units for people with long-term mental illness in Portugal: the PromQual trial.

    Science.gov (United States)

    Cardoso, Graça; Papoila, Ana; Tomé, Gina; Killaspy, Helen; King, Michael; Caldas-de-Almeida, José Miguel

    2017-11-01

    This study aimed to assess the efficacy of a staff-training intervention to improve service users' engagement in activities and quality of care, by means of a cluster randomised controlled trial. All residential units with at least 12-h a day staff support (n = 23) were invited to participate. Quality of care was assessed with the Quality Indicator for Rehabilitative Care (QuIRC) filled online by the unit's manager. Half the units (n = 12) were randomly assigned to continue providing treatment as usual, and half (n = 11) received a staff-training intervention that focused on skills for engaging service users in activities, with trainers working alongside staff to embed this learning in the service. The primary outcome was service users' level of activity (measured with the Time Use Diary), reassessed at 4 and 8 months. Secondary outcomes were the quality of care provided (QuIRC), and service users' quality of life (Manchester Short Assessment of Quality of Life) reassessed at 8 months. Generalized linear mixed effect models were used to assess the difference in outcomes between units in the two trial arms. The trial was registered with Current Controlled Trials (Ref NCT02366117). Knowledge acquired by the staff during the initial workshops increased significantly (p ≤ 0.01). However, the intervention and comparison units did not differ significantly in primary and secondary outcomes at either follow-up. The intervention increased the level of knowledge of staff without leading to an improvement in service users' engagement in activities, quality of life, or quality of care in the units.

  13. Conversovy proměnné stále platí aneb Co ovlivňuje sílu vazeb mezi politickými postoji?

    Czech Academy of Sciences Publication Activity Database

    Linek, Lukáš

    2008-01-01

    Roč. 2, č. 1 (2008), s. 31-47 ISSN 1802-8152 R&D Projects: GA ČR(CZ) GA403/06/1421 Institutional research plan: CEZ:AV0Z70280505 Keywords : attitudes constraints * political attitudes * party identification Subject RIV: AD - Politology ; Political Sciences

  14. Proměna české kuchyně z dob Magdaleny Dobromily Rettigové po současné trendy zdravého životního stylu

    OpenAIRE

    Málková, Simona

    2018-01-01

    The thesis focuses on the topic of changing eating habits from the time of Magdalena Dobromila Rettigová to contemporary trends of healthy lifestyle. It is a gradual development of eating from the late 18th century to the present. In the thereoretic part there is a discription of the contrast of the Czech writer's life and a present-day lifestyle. We can find a chapter about a life of Magdalena Dobromila Rettigová, background information leading up to, writing the cook book "Cooking at home",...

  15. Hybné síly dlouhodobých proměn industrializované krajiny (Případová studie Hrušov)

    Czech Academy of Sciences Publication Activity Database

    Martinát, Stanislav; Dvořák, Petr; Klusáček, Petr; Kunc, Josef; Havlíček, M.

    2014-01-01

    Roč. 106, č. 106 (2014), s. 35-44 ISSN 1805-921X R&D Projects: GA MŠk EE2.3.20.0025 Institutional support: RVO:68145535 Keywords : Hrušov * Ostrava * industrial landscape * deindustrialisation * brownfields Subject RIV: DE - Earth Magnetism, Geodesy, Geography http://www.vukoz.cz/acta/dokumenty/acta_106/Acta-106_komplet-cz.pdf

  16. Dělnický dům a proměny sociálně vyloučené oblasti : Případová studie lokality Brno-Cejl

    Czech Academy of Sciences Publication Activity Database

    Pospíšilová, Jana; Brožovičová, K.

    2015-01-01

    Roč. 13, č. 1 (2015), s. 157-176 ISSN 1429-0618 Institutional support: RVO:68378076 Keywords : Socially excluded areas * Upper and Lower Cejl * Brno * Ethnology * Urban renovation * Roma inhabitants * Anthropology Subject RIV: AC - Archeology, Anthropology , Ethnology

  17. Proměny dětství a vzdělávání v Českých zemích

    OpenAIRE

    Musil, Jan

    2012-01-01

    The diploma work is concetrating on childhood development and it's dependency on spreading and improving in educational system. The work would give an interpretation how education had influenced the period of childhood in the past in Czech countries. What effect had education on childhood duration and quality. The work has chronological system from the beginning of education in Czech countries (monarch St. Václav) to the end of rule Joseph II. Individual chapter give interpretations about edu...

  18. Proměny lékařské terminologie v jednojazyčných výkladových slovnících

    Czech Academy of Sciences Publication Activity Database

    Mžourková, Hana; Nová, Jana; Pernicová, Helena

    2017-01-01

    Roč. 100, č. 4 (2017), s. 215-224 ISSN 0027-8203 R&D Projects: GA MK DF13P01OVV011 Keywords : lexicography * terminology * medicine * monolingual dictionary * Academic Dictionary of Contemporary Czech Subject RIV: AI - Linguistics

  19. Diversifikatsija portovoi promõshlennosti v sootvetstvii s nuzhdami eksportno-importnõhh operatsii = Diversification of port industry in accordance with the demands of export/import operations / Jürgen Sorgenfrei

    Index Scriptorium Estoniae

    Sorgenfrei, Jürgen

    2004-01-01

    11.-12. oktoobrini Peterburis toimunud konverentsil peetud ettekanne. Statistikat Hamburgi sadama kohta. Autor tutvustab tähtsamaid sadamate konkurentsi mõjutavaid faktoreid. Diagrammid, kaardid, skeem. Lisa: Jürgen Sorgenfrei

  20. The SPEIbase: a new gridded product for the analysis of drought variability and drought impacts

    Science.gov (United States)

    Begueria-Portugues, S.; Vicente-Serrano, S. M.; López-Moreno, J. I.; Angulo-Martínez, M.; El Kenawy, A.

    2010-09-01

    Recently a new drought indicator, the Standardised Precipitation-Evapotranspiration Index (SPEI), has been proposed to quantify the drought condition over a given area. The SPEI considers not only precipitation but also evapotranspiration (PET) data on its calculation, allowing for a more complete approach to explore the effects of climate change on drought conditions. The SPEI can be calculated at several time scales to adapt to the characteristic times of response to drought of target natural and economic systems, allowing determining their resistance to drought. Following the formulation of the SPEI a global dataset, the SPEIbase, has been made available to the scientific community. The dataset covers the period 1901-2006 with a monthly frequency, and offers global coverage at a 0.5 degrees resolution. The dataset consists on the monthly values of the SPEI at the time scales from 1 to 48 months. A description of the data and metadata, and links to download the files, are provided at http://sac.csic.es/spei. On this communication we will detail the methodology for computing the SPEI and the characteristics of the SPEIbase. A thorough discussion of the SPEI index, and some examples of use, will be provided in a companion comunication.

  1. Dimensionality of the Knee Numeric-Entity Evaluation Score (KNEES-ACL)

    DEFF Research Database (Denmark)

    Comins, J D; Krogsgaard, M R; Kreiner, Svend

    2013-01-01

    The benefit of anterior cruciate ligament (ACL) reconstruction has been questioned based on patient-reported outcome measures (PROMs). Valid interpretation of such results requires confirmation of the psychometric properties of the PROM. Rasch analysis is the gold standard for validation of PROMs...

  2. Measurement properties of the most commonly used Foot- and Ankle-Specific Questionnaires: the FFI, FAOS and FAAM. A systematic review

    NARCIS (Netherlands)

    Sierevelt, I. N.; Zwiers, R.; Schats, W.; Haverkamp, D.; Terwee, C. B.; Nolte, P. A.; Kerkhoffs, G. M. M. J.

    2017-01-01

    In the foot and ankle literature, a wide range of patient-reported outcome measures (PROMs) is used, however, consensus as to which PROMs are preferred is lacking. Selection of a PROM is among other reasons, often based on measurement properties without considering the methodological quality of the

  3. Headache Night

    Science.gov (United States)

    Maxwell, Lesli A.

    2007-01-01

    The excesses of the modern prom often require principals to play the roles of police, fashion arbiters, and even parents. In the midst of the 2007 junior and senior prom season, school leaders attest to a mounting list of policies, regulations, and security measures they are enforcing for the year's big social event. Indeed, the prom, a…

  4. Manual for procesorienteret musikterapi med personer med BPD

    DEFF Research Database (Denmark)

    Hannibal, Niels; Pedersen, Inge Nygaard; Bonde, Lars Ole

    2012-01-01

    Denne artikel introducerer et musikterapeutisk behandlingskoncept kaldet: Procesorienteret Musikterapi (PROM). PROM er et forsøg på at formulere en principiel ramme for musikterapi i psykiatrien, som dels tager udgangspunkt i 17 års klinisk erfaring, dels stiler mod at være ”best practice”. PROM ...

  5. Patient Self-Assessed Passive Range of Motion of the Knee Cannot Replace Health Professional Measurements

    DEFF Research Database (Denmark)

    Borgbjerg, Jens; Madsen, Frank; Odgaard, Anders

    2017-01-01

    The purpose of this study was to investigate whether patients can accurately self-assess their knee passive range of motion (PROM). A picture-based questionnaire for patient self-assessment of knee PROM was developed and posted to patients. The self-assessed PROM from 58 patients was compared...... (≥ 10-degree flexion contracture). Surgeon- and patient-assessed knee PROM showed a mean difference (95% limits of agreement) of -2.1 degrees (-42.5 to 38.3 degrees) for flexion and -8.1 degrees (-28.8 to 12.7 degrees) for extension. The sensitivity of patient self-assessed PROM in identifying knee...

  6. Patient-reported outcome measures in arthroplasty registries

    DEFF Research Database (Denmark)

    Rolfson, Ola; Eresian Chenok, Kate; Bohm, Eric

    2016-01-01

    survey (SF-12) or the similar Veterans RAND 12-item health survey (VR-12). The most common specific PROMs were the Hip disability and Osteoarthritis Outcome Score (HOOS), the Knee injury and Osteoarthritis Outcome Score (KOOS), the Oxford Hip Score (OHS), the Oxford Knee Score (OKS), the Western Ontario...... of PROMs for hip and knee arthroplasty in registries worldwide. The 2 main types of PROMs include generic (general health) PROMs, which provide a measure of general health for any health state, and specific PROMs, which focus on specific symptoms, diseases, organs, body regions, or body functions...... all elective hip or knee arthroplasty patients and 6 registries collected PROMs for sample populations; 1 other registry had planned but had not started collection of PROMs. The most common generic instruments used were the EuroQol 5 dimension health outcome survey (EQ-5D) and the Short Form 12 health...

  7. A new drought tipping point for conifer mortality

    Science.gov (United States)

    Kolb, Thomas E.

    2015-03-01

    (Huang et al 2015 Environ. Res. Lett. 10 024011) present a method for predicting mortality of ponderosa pine (Pinus ponderosa) and pinyon pine (Pinus edulis) in the Southwestern US during severe drought based on the relationship between the standardized precipitation-evapotranspiration index (SPEI) and annual tree ring growth. Ring growth was zero when SPEI for September to July was -1.64. The threshold SPEI of -1.64 was successful in distinguishing areas with high tree mortality during recent severe drought from areas with low mortality, and is proposed to be a tipping point of drought severity leading to tree mortality. Below, I discuss this work in more detail.

  8. Prospective memory, personality, and individual differences.

    Science.gov (United States)

    Uttl, Bob; White, Carmela A; Wong Gonzalez, Daniela; McDouall, Joanna; Leonard, Carrie A

    2013-01-01

    A number of studies investigating the relationship between personality and prospective memory (ProM) have appeared during the last decade. However, a review of these studies reveals little consistency in their findings and conclusions. To clarify the relationship between ProM and personality, we conducted two studies: a meta-analysis of prior research investigating the relationships between ProM and personality, and a study with 378 participants examining the relationships between ProM, personality, verbal intelligence, and retrospective memory. Our review of prior research revealed great variability in the measures used to assess ProM, and in the methodological quality of prior research; these two factors may partially explain inconsistent findings in the literature. Overall, the meta-analysis revealed very weak correlations (rs ranging from 0.09 to 0.10) between ProM and three of the Big Five factors: Openness, Conscientiousness, and Agreeableness. Our experimental study showed that ProM performance was related to individual differences such as verbal intelligence as well as to personality factors and that the relationship between ProM and personality factors depends on the ProM subdomain. In combination, the two studies suggest that ProM performance is relatively weakly related to personality factors and more strongly related to individual differences in cognitive factors.

  9. The role of decision-making ability in HIV/AIDS: impact on prospective memory.

    Science.gov (United States)

    Coulehan, Kelly; Byrd, Desiree; Arentoft, Alyssa; Monzones, Jennifer; Fuentes, Armando; Fraser, Felicia; Rosario, Ana; Morgello, Susan; Mindt, Monica Rivera

    2014-01-01

    Prospective memory (ProM), a form of episodic memory related to execution of future intentions, is important for everyday functioning. Among persons living with HIV (PLWH), executive dysfunction is implicated in ProM impairments. However, specific subcomponents of executive functioning involved in ProM deficits remain poorly understood. Unlike more "traditional" neurocognitive (NC) measures of executive functioning associated with dorsolateral prefrontal cortex (i.e., conceptual reasoning, abstraction), those associated with medial orbitofrontal/ventromedial prefrontal (mOF/vmP) cortex (i.e., decision making, inhibitory control, goal-oriented behavior) have yet to be examined in ProM. This study characterized ProM ability in a sample of 89 HIV-seropositive adults and examined the unique role of decision-making ability in ProM. Participants completed a standard NC battery, the Iowa Gambling Task (IGT; a decision-making measure), and the Memory for Intentions Screening Test (MIST; a ProM measure). Correlational analyses revealed that both traditional executive functioning measures and the IGT were associated with ProM. Regression analyses revealed that the IGT significantly predicted ProM, even after accounting for NC measures. Among all NC measures, only executive functioning significantly contributed to ProM. Further examination of mOF/vmP-sensitive executive dysfunction within this population is needed as PLWH may require more tailored treatment recommendations due to specific decision-making difficulties that can impact medication management.

  10. Mother-to-child transmission of human immunodeficiency virus (HIV) among HIV-infected pregnant women on highly active anti-retroviral therapy with premature rupture of membranes at term.

    Science.gov (United States)

    Eleje, George Uchenna; Edokwe, Emeka Stephen; Ikechebelu, Joseph Ifeanyichukwu; Onubogu, Chinyere Ukamaka; Ugochukwu, Ebele Francesca; Okam, Princeston Chukwuemeka; Ibekwe, Adaobi Maryann

    2018-01-01

    To determine mother-to-child transmission (MTCT) rate and associated risk factors of human immune-deficiency virus (HIV) among HIV-infected pregnant women with term premature rupture of membranes (PROM) in comparison with those without PROM at term. All optimally managed HIV-positive pregnant women of Nnamdi Azikiwe University Teaching Hospital, on highly active anti-retroviral therapy (HAART) who had PROM at term were enrolled. Maternal HIV-1 viral load was not assessed. Follow up was for a minimum of 18 months for evidence of HIV infection. Of the 121 women with PROM at term, 46 (38.0%) were HIV sero-positive, 22/46 (47.8%) of which had their babies followed up till 18 months. The mean latency period was 10.5 ± 5.3 h in PROM group. Apart from duration of PROM (OR = 0.01; 95%CI = 0.00-0.13; p  0.05). Of the 22 (47.8%) babies followed-up in the PROM group and 13 in non-PROM group, none tested positive to HIV, given an MTCT rate of 0%. MTCT rate was 0% following term PROM and in women without PROM. Since maternal HIV-1 viral load was not assessed, we need to be critical while interpreting the findings.

  11. Transparent meta-analysis: does aging spare prospective memory with focal vs. non-focal cues?

    Directory of Open Access Journals (Sweden)

    Bob Uttl

    Full Text Available BACKGROUND: Prospective memory (ProM is the ability to become aware of a previously-formed plan at the right time and place. For over twenty years, researchers have been debating whether prospective memory declines with aging or whether it is spared by aging and, most recently, whether aging spares prospective memory with focal vs. non-focal cues. Two recent meta-analyses examining these claims did not include all relevant studies and ignored prevalent ceiling effects, age confounds, and did not distinguish between prospective memory subdomains (e.g., ProM proper, vigilance, habitual ProM (see Uttl, 2008, PLoS ONE. The present meta-analysis focuses on the following questions: Does prospective memory decline with aging? Does prospective memory with focal vs. non-focal cues decline with aging? Does the size of age-related declines with focal vs. non-focal cues vary across ProM subdomains? And are age-related declines in ProM smaller than age-related declines in retrospective memory? METHODS AND FINDINGS: A meta-analysis of event-cued ProM using data visualization and modeling, robust count methods, and conventional meta-analysis techniques revealed that first, the size of age-related declines in ProM with both focal and non-focal cues are large. Second, age-related declines in ProM with focal cues are larger in ProM proper and smaller in vigilance. Third, age-related declines in ProM proper with focal cues are as large as age-related declines in recall measures of retrospective memory. CONCLUSIONS: The results are consistent with Craik's (1983 proposal that age-related declines on ProM tasks are generally large, support the distinction between ProM proper vs. vigilance, and directly contradict widespread claims that ProM, with or without focal cues, is spared by aging.

  12. Prospective memory, retrospective memory, and individual differences in cognitive abilities, personality, and psychopathology.

    Science.gov (United States)

    Uttl, Bob; White, Carmela A; Cnudde, Kelsey; Grant, Laura M

    2018-01-01

    Although individual differences in processing speed, working memory, intelligence, and other cognitive functions were found to explain individual differences in retrospective memory (RetM), much less is known about their relationship with prospective memory (ProM). Moreover, the studies that investigated the relationship between ProM and cognitive functions arrived to contradictory conclusions. The relationship between ProM, personality, and psychopathology is similarly unsettled. Meta-analytic reviews of the relationships of ProM with aging and personality suggest that the contradictory findings may be due to widespread methodological problems plaguing ProM research including the prevalent use of inefficient, unreliable binary measures; widespread ceiling effects; failure to distinguish between various ProM subdomains (e.g., episodic ProM versus vigilance/monitoring); various confounds; and, importantly, small sample sizes, resulting in insufficient statistical power. Accordingly, in a large scale study with nearly 1,200 participants, we investigated the relationship between episodic event-cued ProM, episodic RetM, and fundamental cognitive functions including intelligence, personality, and psychopathology, using reliable continuous measures of episodic event-cued ProM. Our findings show that (a) continuous measures of episodic event-cued ProM were much more reliable than binary measures, (b) episodic event-cued ProM was associated with measures of processing speed, working memory, crystallized and fluid intelligence, as well as RetM, and that such associations were similar for ProM and RetM, (c) personality factors did not improve prediction of neither ProM nor RetM beyond the variance predicted by cognitive ability, (d) symptoms of psychopathology did not improve the prediction of ProM although they slightly improved the prediction of RetM, and (e) participants' sex was not associated with ProM but showed small correlations with RetM. In addition to advancing

  13. Using Patient Reported Outcomes Measures to Promote Integrated Care

    Directory of Open Access Journals (Sweden)

    Marcel G. M. Olde Rikkert

    2018-04-01

    Full Text Available Introduction: Patient reported outcome measures (PROMs have been introduced as standardised outcomes, but have not been implemented widely for disease targeted pathways of care, nor for geriatric patients who prefer functional performance and quality of life. Discussion: We describe innovative multipurpose implementation of PROMs as evidenced by two best practices of PROMs application in geriatric and physiotherapy practice. We show that PROMs can show meaningful outcomes in older subjects’ patient journeys, which can at the same time serve individuals and groups of both patients and professionals. Key lesson: PROMs can deliver generic outcomes relevant for older patients, may improve patient-physician relationship, quality of care and prediction of future outcomes in geriatric care, if they are valid, reliable and responsive, but still short and simple. A precondition to make the hard tip from research to practice is that PROMs are carefully positioned in the clinical encounters and in electronic health records.

  14. Exploring standardized precipitation evapotranspiration index for drought assessment in Bangladesh.

    Science.gov (United States)

    Miah, Md Giashuddin; Abdullah, Hasan Muhammad; Jeong, Changyoon

    2017-10-09

    Drought is a critical issue, and it has a pressing, negative impact on agriculture, ecosystems, livelihoods, food security, and sustainability. The problem has been studied globally, but its regional or even local dimension is sometimes overlooked. Local-level drought assessment is necessary for developing adaptation and mitigation strategies for that particular region. Keeping this in understanding, an attempt was made to create a detailed assessment of drought characteristics at the local scale in Bangladesh. Standardized precipitation evapotranspiration (SPEI) is a new drought index that mainly considers the rainfall and evapotranspiration data set. Globally, SPEI has become a useful drought index, but its local scale application is not common. SPEI base (0.5° grid data) for 110 years (1901-2011) was utilized to overcome the lack of long-term climate data in Bangladesh. Available weather data (1955-2011) from Bangladesh Meteorology Department (BMD) were analyzed to calculate SPEI weather station using the SPEI calculator. The drivers for climate change-induced droughts were characterized by residual temperature and residual rainfall data from different BMD stations. Grid data (SPEI base ) of 26 stations of BMD were used for drought mapping. The findings revealed that the frequency and intensity of drought are higher in the northwestern part of the country which makes it vulnerable to both extreme and severe droughts. Based on the results, the SPEI-based drought intensity and frequency analyses were carried out, emphasizing Rangpur (northwest region) as a hot spot, to get an insight of drought assessment in Bangladesh. The findings of this study revealed that SPEI could be a valuable tool to understand the evolution and evaluation of the drought induced by climate change in the country. The study also justified the immediate need for drought risk reduction strategies that should lead to relevant policy formulations and agricultural innovations for developing

  15. A Standardized Precipitation Evapotranspiration Index Reconstruction in the Taihe Mountains Using Tree-Ring Widths for the Last 283 Years.

    Directory of Open Access Journals (Sweden)

    Yongyong Ma

    Full Text Available Tree-ring samples from Chinese Pine (Pinus tabulaeformis Carr. that were collected in the Taihe Mountains on the western Loess Plateau, China, were used to analyze the effects of climate and drought on radial growth and to reconstruct the mean April-June Standardized Precipitation Evapotranspiration Index (SPEI during the period 1730-2012 AD. Precipitation positively affected tree growth primarily during wet seasons, while temperature negatively affected tree growth during dry seasons. Tree growth responded positively to SPEI at long time scales most likely because the trees were able to withstand water deficits but lacked a rapid response to drought. The 10-month scale SPEI was chosen for further drought reconstruction. A calibration model for the period 1951-2011 explained 51% of the variance in the modeled SPEI data. Our SPEI reconstruction revealed long-term patterns of drought variability and captured some significant drought events, including the severe drought of 1928-1930 and the clear drying trend since the 1950s which were widespread across northern China. The reconstruction was also consistent with two other reconstructions on the western Loess Plateau at both interannual and decadal scales. The reconstructed SPEI series showed synchronous variations with the drought/wetness indices and spatial correlation analyses indicated that this reconstruction could be representative of large-scale SPEI variability in northern China. Period analysis discovered 128-year, 25-year, 2.62-year, 2.36-year, and 2.04-year cycles in this reconstruction. The time-dependency of the growth response to drought should be considered in further studies of the community dynamics. The SPEI reconstruction improves the sparse network of long-term climate records for an enhanced understanding of climatic variability on the western Loess Plateau, China.

  16. A Standardized Precipitation Evapotranspiration Index Reconstruction in the Taihe Mountains Using Tree-Ring Widths for the Last 283 Years

    Science.gov (United States)

    Ma, Yongyong; Liu, Yu; Song, Huiming; Sun, Junyan; Lei, Ying; Wang, Yanchao

    2015-01-01

    Tree-ring samples from Chinese Pine (Pinus tabulaeformis Carr.) that were collected in the Taihe Mountains on the western Loess Plateau, China, were used to analyze the effects of climate and drought on radial growth and to reconstruct the mean April-June Standardized Precipitation Evapotranspiration Index (SPEI) during the period 1730–2012 AD. Precipitation positively affected tree growth primarily during wet seasons, while temperature negatively affected tree growth during dry seasons. Tree growth responded positively to SPEI at long time scales most likely because the trees were able to withstand water deficits but lacked a rapid response to drought. The 10-month scale SPEI was chosen for further drought reconstruction. A calibration model for the period 1951–2011 explained 51% of the variance in the modeled SPEI data. Our SPEI reconstruction revealed long-term patterns of drought variability and captured some significant drought events, including the severe drought of 1928–1930 and the clear drying trend since the 1950s which were widespread across northern China. The reconstruction was also consistent with two other reconstructions on the western Loess Plateau at both interannual and decadal scales. The reconstructed SPEI series showed synchronous variations with the drought/wetness indices and spatial correlation analyses indicated that this reconstruction could be representative of large-scale SPEI variability in northern China. Period analysis discovered 128-year, 25-year, 2.62-year, 2.36-year, and 2.04-year cycles in this reconstruction. The time-dependency of the growth response to drought should be considered in further studies of the community dynamics. The SPEI reconstruction improves the sparse network of long-term climate records for an enhanced understanding of climatic variability on the western Loess Plateau, China. PMID:26207621

  17. 7 CFR 905.23 - Selection.

    Science.gov (United States)

    2010-01-01

    ... affiliated with bona fide cooperative marketing organizations. (b) From the nominations made pursuant to... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... alternates to represent bona fide cooperative marketing organizations which are handlers, and the remaining...

  18. How Do We Value Postoperative Recovery?: A Systematic Review of the Measurement Properties of Patient-reported Outcomes After Abdominal Surgery.

    Science.gov (United States)

    Fiore, Julio F; Figueiredo, Sabrina; Balvardi, Saba; Lee, Lawrence; Nauche, Bénédicte; Landry, Tara; Mayo, Nancy E; Feldman, Liane S

    2018-04-01

    To appraise the level of evidence supporting the measurement properties of patient-reported outcome measures (PROMs) in the context of postoperative recovery after abdominal surgery. There is growing interest in using PROMs to support value-based care in abdominal surgery; however, to draw valid conclusions regarding patient-reported outcomes data, PROMs with robust measurement properties are required. Eight databases (MEDLINE, EMBASE, Biosis, PsycINFO, The Cochrane Library, CINAHL, Scopus, Web of Science) were searched for studies focused on the measurement properties of PROMs in the context of recovery after abdominal surgery. The methodological quality of individual studies was evaluated using the consensus-based COSMIN checklist. Evidence supporting the measurement properties of each PROM was synthetized according to standardized criteria and compared against the International Society of Quality of Life Research minimum standards for the selection of PROMs for outcomes research. We identified 35 studies evaluating 22 PROMs [12 focused on nonspecific surgical populations (55%), 4 focused on abdominal surgery (18%), and 6 generic PROMs (27%)]. The great majority of the studies (74%) received only poor or fair quality ratings. Measurement properties of PROMs were predominantly supported by limited or unknown evidence. None of the PROMs fulfilled International Society of Quality of Life Research's minimum standards, hindering specific recommendations. There is very limited evidence supporting the measurement properties of existing PROMs used in the context of recovery after abdominal surgery. This precludes the use of these PROMs to support value-based surgical care. Further research is required to bridge this major knowledge gap. International Prospective Register of Systematic Reviews (PROSPERO): CRD42014014349.

  19. Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium

    OpenAIRE

    Bhattacharya, Sujoy; Yin, Jinggang; Winborn, Christina S.; Zhang, Qiuhua; Yue, Junming; Chaum, Edward

    2017-01-01

    Purpose Prominin-1 (Prom1) is a transmembrane glycoprotein, which is expressed in stem cell lineages, and has recently been implicated in cancer stem cell survival. Mutations in the Prom1 gene have been shown to disrupt photoreceptor disk morphogenesis and cause an autosomal dominant form of Stargardt-like macular dystrophy (STGD4). Despite the apparent structural role of Prom1 in photoreceptors, its role in other cells of the retina is unknown. The purpose of this study is to investigate the...

  20. Action principle for the generalized harmonic formulation of general relativity

    International Nuclear Information System (INIS)

    Brown, J. David

    2011-01-01

    An action principle for the generalized harmonic formulation of general relativity is presented. The action is a functional of the spacetime metric and the gauge source vector. An action principle for the Z4 formulation of general relativity has been proposed recently by Bona, Bona-Casas, and Palenzuela. The relationship between the generalized harmonic action and the Bona, Bona-Casas, and Palenzuela action is discussed in detail.

  1. The clinical and microbiological correlates of premature rupture of membranes

    Directory of Open Access Journals (Sweden)

    Karat C

    2006-01-01

    Full Text Available Prematurity is the cause of 85% of neonatal morbidity and mortality. Premature rupture of the membranes (PROM is associated with 30-40% of preterm deliveries. A case-control study conducted between July 2002 and 2003 examined the correlates and risk factors for PROM in Mysore, India. WBCs in vaginal fluid, leucocytes in urine, UTI and infection with E . coli , S . aureus , C. albicans and BV were significantly associated with PROM. BV, E. coli and WBCs in vaginal fluid were independent risk factors. Screening and treatment of BV and E. coli infection in pregnancy may reduce the risk of PROM.

  2. The clinical and microbiological correlates of premature rupture of membranes.

    Science.gov (United States)

    Karat, C; Madhivanan, P; Krupp, K; Poornima, S; Jayanthi, N V; Suguna, J S; Mathai, E

    2006-10-01

    Prematurity is the cause of 85% of neonatal morbidity and mortality. Premature rupture of the membranes (PROM) is associated with 30-40% of preterm deliveries. A case-control study conducted between July 2002 and 2003 examined the correlates and risk factors for PROM in Mysore, India. WBCs in vaginal fluid, leucocytes in urine, UTI and infection with E. coli, S. aureus, C. albicans and BV were significantly associated with PROM. BV, E. coli and WBCs in vaginal fluid were independent risk factors. Screening and treatment of BV and E. coli infection in pregnancy may reduce the risk of PROM.

  3. Diagnostic performance of placental alpha-microglobulin-1 test in women with prolonged pre-labour rupture of membranes.

    Science.gov (United States)

    Eleje, George Uchenna; Ezugwu, Euzebus Chinonye; Eke, Ahizechukwu Chigoziem; Eleje, Lydia Ijeoma; Ikechebelu, Joseph Ifeanyichukwu; Afiadigwe, Evaristus Anthony; Ezugwu, Frank O; Udigwe, Gerald Okanandu; Okafor, Charles I; Ezeama, Chukwuemeka Okwudili

    2016-01-01

    To determine diagnostic performance of placental alpha-microglobulin-1 (PAMG-1) test compared to conventional clinical assessment (CCA) in women with prolonged pre-labour rupture of membranes (PROM). A double-blind study of women with symptoms and signs of PROM in Nnamdi Azikiwe University Teaching Hospital, Nnewi and University of Nigeria Teaching Hospital, Enugu, in south-east Nigeria using CCA for PROM and PAMG-1 test was done. Women were included if their symptoms, signs or complaints suggestive of PROM was more than 24 h duration. PROM was diagnosed if two out of three methods from CCA (pooling, positive nitrazine test or ferning) were present. Confirmation of PROM was done after delivery using any two of these clinical criteria: delivery in 48 h to 7 days, evidence of chorioamnionitis, membranes obviously ruptured at delivery and adverse perinatal outcomes strongly correlated with prolonged PROM. Accuracy, specificity and sensitivity value for CCA were 72.5, 36.8 and 86.0% lower than for PAMG-1 test which were 95.7, 94.1 and 96.2%. In equivocal cases, PAMG-1 was significantly more accurate than CCA (92.3% versus 38.5%; p < 0.001). This study in women with prolonged PROM, confirms that PAMG-1 test has high diagnostic accuracy irrespective of the duration of PROM before clinical evaluation.

  4. 26 CFR 1.132-5T - Working condition fringe-1985 through 1988 (temporary).

    Science.gov (United States)

    2010-04-01

    ... United States, a factor indicating a bona fide business-oriented security concern is threats on the life... is primarily personal. If, however, for bona fide business-oriented security concerns, the employee... have paid for the same mode of transportation absent the bona fide business-oriented security concerns...

  5. 76 FR 48884 - Stacey J. Webb, M.D.; Denial of Application

    Science.gov (United States)

    2011-08-09

    ... and maintain a bona fide doctor-patient relationship in order to act ``in the usual course of... whom they did not establish a bona-fide doctor-patient relationship, DEA has denied pending... prescriptions outside bona fide doctor-patient relationship with customers of a website); see also Ronald Lynch...

  6. Measurement properties of patient reported outcome measures for spondyloarthritis: A systematic review.

    Science.gov (United States)

    Png, Kelly; Kwan, Yu Heng; Leung, Ying Ying; Phang, Jie Kie; Lau, Jia Qi; Lim, Ka Keat; Chew, Eng Hui; Low, Lian Leng; Tan, Chuen Seng; Thumboo, Julian; Fong, Warren; Østbye, Truls

    2018-03-21

    This systematic review aimed to identify studies investigating measurement properties of patient reported outcome measures (PROMs) for spondyloarthritis (SpA), and to evaluate their methodological quality and level of evidence relating to the measurement properties of PROMs. This systematic review was guided by the preferred reporting items for systematic review and meta-analysis (PRISMA). Articles published before 30 June 2017 were retrieved from PubMed ® , Embase ® , and PsychINFO ® (Ovid). Methodological quality and level of evidence were evaluated according to recommendations from the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN). We identified 60 unique PROMs from 125 studies in 39 countries. Twenty-one PROMs were validated for two or more SpA subtypes. The literature examined hypothesis testing (82.4%) most frequently followed by reliability (60.0%). A percentage of 77.7% and 42.7% of studies that assessed PROMs for hypothesis testing and reliability, respectively had "fair" or better methodological quality. Among the PROMs identified, 41.7% were studied in ankylosing spondylitis (AS) only and 23.3% were studied in psoriatic arthritis (PsA) only. The more extensively assessed PROMs included the ankylosing spondylitis quality of life (ASQoL) and bath ankylosing spondylitis functional index (BASFI) for ankylosing spondylitis, and the psoriatic arthritis quality of life questionnaire (VITACORA-19) for psoriatic arthritis. This study identified 60 unique PROMs through a systematic review and synthesized evidence of the measurement properties of the PROMs. There is a lack of validation of PROMs for use across SpA subtypes. Future studies may consider validating PROMs for use across different SpA subtypes. Copyright © 2018 Elsevier Inc. All rights reserved.

  7. The impact of patient-reported outcome measures in clinical practice for pain: a systematic review.

    Science.gov (United States)

    Holmes, Michelle M; Lewith, George; Newell, David; Field, Jonathan; Bishop, Felicity L

    2017-02-01

    Patient-reported outcome measures (PROMs) have increasingly been incorporated into clinical practice. Research suggests that PROMs could be viewed as active components of complex interventions and may affect the process and outcome of care. This systematic review examines PROMs in the context of treatment for non-malignant pain. An electronic search on: MEDLINE, EMBASE, PsycINFO, PsycARTICLES, Cochrane Library and Web of Science identified relevant papers (February 2015). The inclusion criteria were: focused on implementing PROMs into clinical practice, adults, and primary data studies. Critical interpretive synthesis was used to synthesise qualitative and quantitative findings into a theoretical argument. Thirteen eligible studies were identified. Synthesis suggested that PROMs may be included in the initial consultation to assess patients and for shared decision-making regarding patient care. During the course of treatment, PROMs can be used to track progress, evaluate treatment, and change the course of care; using PROMs may also influence the therapeutic relationship. Post-treatment, using PROMs might directly influence other outcomes such as pain and patient satisfaction. However, although studies have investigated these areas, evidence is weak and inconclusive. Due to the poor quality, lack of generalisability and heterogeneity of these studies, it is not possible to provide a comprehensive understanding of how PROMs may impact clinical treatment of non-malignant pain. The literature suggests that PROMs enable pain assessment, decision-making, the therapeutic relationship, evaluation of treatment and may influence outcomes. Further research is needed to provide better evidence as to whether PROMs do indeed have any effects on these domains.

  8. Antioxidant Vitamin Status in the Serum and Amniotic Fluid of Women with Premature Rupture of the Fetal Membranes.

    Science.gov (United States)

    Barrett, Bridget M.

    The purpose of this study was to examine the status of antioxidant vitamins in women with premature rupture of the fetal membranes. Specimens of blood and amniotic fluid were obtained from 80 pregnant subjects included both smokers and non-smokers during the third trimester. The concentrations of ascorbic acid (ASA), beta -carotene, retinol and alpha -tocopherol in serum and amniotic fluid were determined. The experimental group consisted of those subjects with PROM while the control subjects were those with normal pregnancy. No statistical differences were found between the PROM and control groups in retinol and vitamin E concentrations in amniotic fluid and serum. Serum ASA concentrations of PROM subjects were not different from controls, but the PROM subjects had significantly lower amniotic fluid ASA concentrations. However, in a study with fewer subjects a lower serum ASA concentration in the PROM subjects was observed. The ratio of amniotic fluid ASA concentration to ASA serum concentration was significantly lower in PROM patients than in controls in both studies. This suggests that low levels of ASA in the amniotic fluid, but not in serum is better associated with PROM. A low amniotic fluid concentration of ASA may reflect an inefficient transfer and/or increased fetal utilization. Alterations in ASA concentration in the amniotic fluid may affect the integrity of the chorioamnion leading to PROM. beta -Carotene was not found in the amniotic fluid. Serum beta-carotene levels were significantly lower in the PROM group compared to the control group. Low concentrations of beta-carotene in maternal serum in smokers not only associated with poor maternal outcome (PROM) but also compromised the fetal outcome (decreased birth weight). Maintenance of adequate serum beta-carotene concentration and amniotic fluid ASA in smokers may result in better maternal and fetal outcome. This study demonstrated that nutrition is an important factor in the prevention of PROM.

  9. Trends and Tipping Points of Drought-induced Tree Mortality

    Science.gov (United States)

    Huang, K.; Yi, C.; Wu, D.; Zhou, T.; Zhao, X.; Blanford, W. J.; Wei, S.; Wu, H.; Du, L.

    2014-12-01

    Drought-induced tree mortality worldwide has been recently reported in a review of the literature by Allen et al. (2010). However, a quantitative relationship between widespread loss of forest from mortality and drought is still a key knowledge gap. Specifically, the field lacks quantitative knowledge of tipping point in trees when coping with water stress, which inhibits the assessments of how climate change affects the forest ecosystem. We investigate the statistical relationships for different (seven) conifer species between Ring Width Index (RWI) and Standardized Precipitation Evapotranspiration Index (SPEI), based on 411 chronologies from the International Tree-Ring Data Bank across 11 states of the western United States. We found robust species-specific relationships between RWI and SPEI for all seven conifer species at dry condition. The regression models show that the RWI decreases with SPEI decreasing (drying) and more than 76% variation of tree growth (RWI) can be explained by the drought index (SPEI). However, when soil water is sufficient (i.e., SPEI>SPEIu), soil water is no longer a restrictive factor for tree growth and, therefore, the RWI shows a weak correlation with SPEI. Based on the statistical models, we derived the tipping point of SPEI (SPEItp) where the RWI equals 0, which means the carbon efflux by tree respiration equals carbon influx by tree photosynthesis. When the severity of drought exceeds this tipping point(i.e. SPEIsupported by the Fund for Creative Research Groups of National Natural Science Foundation of China (No. 41321001), the National Basic Research Program of China (No. 2012CB955401), the New Century Excellent Talents in University (No. NCET-10-0251), U.S. PSC-CUNY Award (PSC-CUNY-ENHC-44-83) and the High Technology Research and Development Program of China (No. 2013AA122801).

  10. Assessing the utility of meteorological drought indices in monitoring summer drought based on soil moisture in Chongqing, China

    Science.gov (United States)

    Chen, Hui; Wu, Wei; Liu, Hong-Bin

    2018-04-01

    Numerous drought indices have been developed to analyze and monitor drought condition, but they are region specific and limited by various climatic conditions. In southwest China, summer drought mainly occurs from June to September, causing destructive and profound impact on agriculture, society, and ecosystems. The current study assesses the availability of meteorological drought indices in monitoring summer drought in this area at 5-day scale. The drought indices include the relative moisture index ( M), the standardized precipitation index (SPI), the standardized precipitation evapotranspiration index (SPEI), the composite index of meteorological drought (CIspi), and the improved composite index of meteorological drought (CIwap). Long-term daily precipitation and temperature from 1970 to 2014 are used to calculate 30-day M ( M 30), SPI (SPI30), SPEI (SPEI30), 90-day SPEI (SPEI90), CIspi, and CIwap. The 5-day soil moisture observations from 2010 to 2013 are applied to assess the performance of these drought indices. Correlation analysis, overall accuracy, and kappa coefficient are utilized to investigate the relationships between soil moisture and drought indices. Correlation analysis indicates that soil moisture is well correlated with CIwap, SPEI30, M 30, SPI30, and CIspi except SPEI90. Moreover, drought classifications identified by M 30 are in agreement with that of the observed soil moisture. The results show that M 30 based on precipitation and potential evapotranspiration is an appropriate indicator for monitoring drought condition at a finer scale in the study area. According to M 30, summer drought during 1970-2014 happened in each year and showed a slightly upward tendency in recent years.

  11. Climate trends and behaviour of drought indices based on precipitation and evapotranspiration in Portugal

    Directory of Open Access Journals (Sweden)

    A. A. Paulo

    2012-05-01

    Full Text Available Distinction between drought and aridity is crucial to understand water scarcity processes. Drought indices are used for drought identification and drought severity characterisation. The Standardised Precipitation Index (SPI and the Palmer Drought Severity Index (PDSI are the most known drought indices. In this study, they are compared with the modified PDSI for Mediterranean conditions (MedPDSI and the Standardised Precipitation Evapotranspiration Index (SPEI. MedPDSI results from the soil water balance of an olive crop, thus real evapotranspiration is considered, while SPEI uses potential (climatic evapotranspiration. Similarly to the SPI, SPEI can be computed at various time scales. Aiming at understanding possible impacts of climate change, prior to compare the drought indices, a trend analysis relative to precipitation and temperature in 27 weather stations of Portugal was performed for the period 1941 to 2006. A trend for temperature increase was observed for some weather stations and trends for decreasing precipitation in March and increasing in October were also observed for some locations. Comparisons of the SPI and SPEI at 9- and 12-month time scales, the PDSI and MedPDSI were performed for the same stations and period. SPI and SPEI produce similar results for the same time scales concerning drought occurrence and severity. PDSI and MedPDSI correlate well between them and the same happened for SPI and SPEI. PDSI and MedPDSI identify more severe droughts than SPI or SPEI and identify drought occurrence earlier than these indices. This behaviour is likely to be related with the fact that a water balance is performed with PDSI and MedPDSI, which better approaches the supply-demand balance.

  12. Maternal characteristics and timing of presentation following pre ...

    African Journals Online (AJOL)

    Background: To examine the influence of maternal characteristics on timing of presentation for intervention following pre-labour rupture of membrane (PROM) at term. Materials and Methods: This was a descriptive study of cases of term PROM with singleton births at the University of Benin Teaching Hospital (UBTH) from ...

  13. Premature rupture of membranes at term: immediate induction of ...

    African Journals Online (AJOL)

    Objective: To compare the maternal outcomes of immediate induction of labor with expectant management in women presenting with premature rupture of membranes (PROM) at term. Methods: One hundred and fifty two women with PROM at term were randomized into either immediate induction of labor with oxytocin or ...

  14. Prospective Memory Deficits in Ecstasy Users: Effects of Longer Ongoing Task Delay Interval

    Science.gov (United States)

    WEINBORN, MICHAEL; WOODS, STEVEN PAUL; NULSEN, CLAIRE; PARK, KATHERINE

    2011-01-01

    Ecstasy use has been associated with neurotoxicity and neurocognitive impairment in a variety of domains, including prospective memory (ProM), which involves the delayed execution of a previously encoded intention in response to a specific cue. The present study adopted the multiprocess theory of ProM to evaluate the hypothesis that ecstasy users would evidence differentially impaired ProM on longer versus shorter ongoing task delays. Ecstasy (n = 31) users, high-risk alcohol users (n = 21) and healthy nonusers (n = 31) completed the short (2-min) and long (15-min) delay ProM scales of the Memory for Intentions Screening Test. Results showed a significant group by ProM delay interaction, such that ecstasy users performed comparably to the comparison groups on short-delay trials, but were impaired on long-delay ProM, particularly for time-based cues. Among the ecstasy users, long-delay ProM was positively associated with risky decision-making, but not with retrospective memory or other aspects of executive functions. These findings suggest that ecstasy users may be particularly susceptible to deficits in strategic target monitoring and maintenance of cue-intention pairings over longer ProM delays. Findings are discussed in the context of their potential everyday functioning (e.g., academic, vocational) and treatment implications for ecstasy users. PMID:22047194

  15. Absence of Circadian Rhythms of Preterm Premature Rupture of Membranes and Preterm Placental Abruption

    Science.gov (United States)

    Luque-Fernandez, Miguel Angel; Ananth, Cande V.; Sanchez, Sixto E.; Qiu, Chun-fang; Hernandez-Diaz, Sonia; Valdimarsdottir, Unnur; Gelaye, Bizu; Williams, Michelle A.

    2014-01-01

    Purpose Data regarding circadian rhythm in the onset of spontaneous preterm premature rupture of membranes (PROM) and placental abruption (PA) cases are conflicting. We modeled the time of onset of preterm PROM and PA cases and examined if the circadian profiles varied based on the gestational age at delivery. Methods We used parametric and nonparametric methods, including trigonometric regression in the framework of generalized linear models, to test the presence of circadian rhythms in the time of onset of preterm PROM and PA cases, among 395 women who delivered a singleton between 2009 and 2010 in Lima, Peru. Results We found a diurnal circadian pattern, with a morning peak at 07h:32’ (95%CI:05h:46’ – 09h:18’) among moderate preterm PROM cases (P-value<0.001), and some evidence of a diurnal circadian periodicity among PA cases in term infants (P-value=0.067). However, we did not find evidence of circadian rhythms in the time of onset of extremely or very preterm PROM (P-value=0.259) and preterm PA (P-value=0.224). Conclusions The circadian rhythms of the time of onset of preterm PROM and PA cases varied based on gestational weeks at delivery. While circadian rhythms were presented among moderate preterm PROM and term PA cases, there was no evidence of circadian rhythms among preterm PA and very or extremely preterm PROM cases, underlying other mechanisms associated with the time of onset. PMID:25453346

  16. Self-report measures of prospective memory are reliable but not valid.

    Science.gov (United States)

    Uttl, Bob; Kibreab, Mekale

    2011-03-01

    Are self-report measures of prospective memory (ProM) reliable and valid? To examine this question, 240 undergraduate student volunteers completed several widely used self-report measures of ProM including the Prospective Memory Questionnaire (PMQ), the Prospective and Retrospective Memory Questionnaire (PRMQ), the Comprehensive Assessment of Prospective Memory (CAPM) questionnaire, self-reports of retrospective memory (RetM), objective measures of ProM and RetM, and measures of involvement in activities and events, memory strategies and aids use, personality and verbal intelligence. The results showed that both convergent and divergent validity of ProM self-reports are poor, even though we assessed ProM using a newly developed, reliable continuous measure. Further analyses showed that a substantial proportion of variability in ProM self-report scores was due to verbal intelligence, personality (conscientiousness, neuroticism), activities and event involvement (busyness), and use of memory strategies and aids. ProM self-reports have adequate reliability, but poor validity and should not be interpreted as reflecting ProM ability. (PsycINFO Database Record (c) 2011 APA, all rights reserved).

  17. Using patient reported outcome measures in health services: A qualitative study on including people with low literacy skills and learning disabilities

    NARCIS (Netherlands)

    Jahagirdar, D.; Kroll, T.; Ritchie, K.; Wyke, S.

    2012-01-01

    ABSTRACT: BACKGROUND: Patient reported outcome measures (PROMs) are self-report measures of health status increasingly promoted for use in healthcare quality improvement. However people with low literacy skills or learning disabilities may find PROMs hard to complete. Our study investigated

  18. Activin A and its regulatory molecules in placenta and fetal membranes of women with preterm premature rupture of the membranes associated with acute chorioamnionitis.

    Science.gov (United States)

    Torricelli, Michela; Voltolini, Chiara; Novembri, Romina; Bocchi, Caterina; Di Tommaso, Mariarosaria; Severi, Filiberto M; Petraglia, Felice

    2012-11-01

    LABELED PROBLEM: To investigate regulation of activin A and related molecules in placenta/fetal membranes from preterm premature rupture of membranes (pPROM) associated with acute chorioamnionitis (ACA). Tissues were obtained from women with spontaneous preterm deliveries (PTD), pPROM without ACA, pPROM with ACA. Activin A, follistatin, and nodal and cripto mRNA were measured by RT-PCR. Activin A mRNA was up-regulated in tissues from pPROM, in presence or absence of HCA, respect to PTD and in pPROM with ACA respect to pPROM without ACA. Follistatin mRNA expression did not differ between the groups. In placenta, nodal mRNA showed the same trend of activin A, while cripto was down-regulated in pPROM with ACA than other groups. Nodal and cripto were not expressed by fetal membranes. The study shows the involvement of activin A pathway in pPROM with ACA. Further studies will focus on its role in placental immune functions. © 2012 John Wiley & Sons A/S.

  19. The relative proportion of preterm births complicated by premature rupture of membranes in multifetal gestations: a population-based study.

    Science.gov (United States)

    Pakrashi, Tarita; Defranco, Emily A

    2013-01-01

    To compare the relative contribution of premature rupture of membranes (PROM) to preterm births in singleton compared with multifetal gestations. A population-based retrospective cohort study of 291,782 nonanomalous live births in the state of Ohio from January 1, 2006, to December 31, 2007, identified through birth certificate data. Frequency of PROM was compared between singleton and multifetal gestations and then stratified by gestational age at birth. Multivariate regression analysis estimated the risk of PROM by plurality in each gestational age group, accounting for influential risk factors. The frequency of PROM increased with increasing plurality of gestation. The relative proportion of preterm birth < 37 weeks complicated by PROM increased with gestational plurality 13.2% singletons, 16.8% twins, 20.0% triplets, 19.6% quadruplets, and 100% for higher-order multiples (p < 0.001). The frequency of PROM increased with earlier gestational age at birth, regardless of plurality. The increased risk of PROM in multifetal gestation persisted even after adjustment for influential concomitant risk factors. The proportion of preterm birth attributable to PROM increases by plurality of gestation, with its most significant contribution in higher-order multiples and at earliest gestational ages when outcomes are the poorest. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  20. An operational decision support framework for monitoring business constraints

    NARCIS (Netherlands)

    Maggi, F.M.; Montali, M.; Aalst, van der W.M.P.; Lara, de J.; Zisman, A.

    2012-01-01

    Only recently, process mining techniques emerged that can be used for Operational decision Support (OS), i.e., knowledge extracted from event logs is used to handle running process instances better. In the process mining tool ProM, a generic OS service has been developed that allows ProM to

  1. Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro.

    Science.gov (United States)

    Menon, Ramkumar; Boldogh, Istvan; Hawkins, Hal K; Woodson, Michael; Polettini, Jossimara; Syed, Tariq Ali; Fortunato, Stephen J; Saade, George R; Papaconstantinou, John; Taylor, Robert N

    2014-06-01

    Preterm prelabor rupture of the membranes (pPROM) may lead to preterm births (PTBs). We investigated premature senescence of fetal membranes in women with pPROM and spontaneous PTB with intact membranes (PTBs, and term births. Term fetal membranes were exposed to cigarette smoke extract to induce oxidative stress. Western blots documented p-p53 and p-p38 MAPK. Transmission electron microscopy assessed cellular morphologic features in clinical and cigarette smoke extract-treated membranes. A total of 80% of pPROM cells and >60% of term cells were positive for all three senescence phenotype markers, and concentrations were higher than in PTBs (P PTBs. Histologic and biochemical resemblance of pPROM and term membranes suggests premature senescence of the membranes is a mechanistic feature in pPROM, and this can be phenocopied in an in vitro model. Copyright © 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  2. MANUAL FOR PROCESORIENTERET MUSIKTERAPI MED PERSONER MED BPD.

    Directory of Open Access Journals (Sweden)

    Niels Hannibal

    2010-12-01

    Full Text Available Denne artikel introducerer et musikterapeutisk behandlingskoncept kaldet: Procesorienteret Musikterapi (PROM. PROM er et forsøg på at formulere en principiel ramme for musikterapi i psykiatrien, som dels tager udgangspunkt i 17 års klinisk erfaring, dels stiler mod at være ”best practice”. PROM indeholder beskrivelser af manualens unikke, essentielle men ikke unikke, acceptable og ikke acceptable dele. Den unikke del af PROM skal kunne implementeres til alle målgrupper, mens de øvrige dele af manualen rettes til i forhold til en specifik målgruppe. Denne udgave af PROM er specifikt rettet i mod musikterapi for patienter med personlighedsforstyrrelser. Manualen indgår også som en del af et pilotprojekt, der har til formål at udvikle en protokol for et internationalt RCT projekt med samme målgruppe

  3. Measuring Patient-Reported Outcomes: Key Metrics in Reconstructive Surgery.

    Science.gov (United States)

    Voineskos, Sophocles H; Nelson, Jonas A; Klassen, Anne F; Pusic, Andrea L

    2018-01-29

    Satisfaction and improved quality of life are among the most important outcomes for patients undergoing plastic and reconstructive surgery for a variety of diseases and conditions. Patient-reported outcome measures (PROMs) are essential tools for evaluating the benefits of newly developed surgical techniques. Modern PROMs are being developed with new psychometric approaches, such as Rasch Measurement Theory, and their measurement properties (validity, reliability, responsiveness) are rigorously tested. These advances have resulted in the availability of PROMs that provide clinically meaningful data and effectively measure functional as well as psychosocial outcomes. This article guides the reader through the steps of creating a PROM and highlights the potential research and clinical uses of such instruments. Limitations of PROMs and anticipated future directions in this field are discussed.

  4. Proměna presidenta o dvou jednáních. Z kampaně proti buržoasním padělatelům dějin 1948–1953 // Transformations of a president in two acts. From a campaign against bourgeois falsifiers of history 1948-1953

    Directory of Open Access Journals (Sweden)

    Josef Nožička

    2017-11-01

    Full Text Available The paper examines the influence of a Soviet campaign against bourgeois falsifiers of history on the development and transformations of the image of President Edvard Beneš in Czechoslovak historiography in the early 1950s through an interpretation of the role of Beneš during the 1938 crisis.

  5. Způsoby hlasování ve volbách a jejich historický vývoj: hlasovací technika jako stěžejní proměnná volebního procesu

    Directory of Open Access Journals (Sweden)

    Sylvie Reterová

    2007-08-01

    Full Text Available This paper examines the issue of ballot voting in elections with a focus on traditional and modern voting methods. The purpose is to provide policy analysis with a survey of the development of voting methods, from their earliest form up to contemporary democratic technologies. The study offers a systematic evaluation of the voting mechanism, especially the paper ballot, machine voting, punchcard voting, optical mark-sense voting and electronic voting. On the basis of case studies, their impact on electoral process and the accuracy of election results is evaluated, as well as their impact on the quality of democracy. The accent is put on voting procedures which are user-friendly and trustworthy at the same time.

  6. DIY or Die! Proměny českých a slovenských hardcore-punkových scén a fanzinů od 90. let 20. století do současnosti

    Directory of Open Access Journals (Sweden)

    Jiří Almer

    2017-01-01

    Full Text Available This study deals with the changes within Czech and Slovak hardcore-punk fanzines from the beginning of 90s up to the present time. It’s based on research into youth subculture and also on the interpretation of “independent” literature in accordance with media studies. Firstly, it analyzes marginal subculture (or scene of hardcore-punk and focuses on its production, meaning printed fanzines. Secondly the study asks whether those fanzines could be considered as “contraculture”, therefore an independent or antagonistic sphere against so called mainstream cultural production. The main object of the thesis is the enumeration of Czech and Slovak fanzines in the above mentioned period and mainly interpretations of political topics reflected in that mags, as well as their changes and corrections.

  7. Slovanský přehled a jeho přínos k interpretaci dějin Sovětského svazu. Proměny výzkumu od konce 50. let do nástupu normalizace

    Czech Academy of Sciences Publication Activity Database

    Voráček, Emil

    2015-01-01

    Roč. 101, č. 3 (2015), s. 529-559 ISSN 0037-6922 Institutional support: RVO:67985963 Keywords : Slavonic Review * sovietology * history of the Soviet Union * deideologization * stalinism Subject RIV: AB - History

  8. "Krista tedy hlásat v národu svém". Několik poznámek ke kořenům a proměnám cyrilometodějství v 19. století.

    Czech Academy of Sciences Publication Activity Database

    Zobačová, Andrea

    2014-01-01

    Roč. 17, č. 1 (2014), s. 101-113 ISSN 1212-1509 Institutional support: RVO:68378076 Keywords : Saints Cyril and Methodius * church * national movement * Czech language Subject RIV: AC - Archeology, Anthropology, Ethnology

  9. Proměny v mezigeneračním přenosu dosaženého vzdělání v České republice v historické perspektivě

    Czech Academy of Sciences Publication Activity Database

    Simonová, Natalie

    2009-01-01

    Roč. 45, č. 2 (2009), s. 291-313 ISSN 0038-0288 R&D Projects: GA ČR(CZ) GA403/06/1241; GA ČR GA403/08/0109 Institutional research plan: CEZ:AV0Z70280505 Keywords : access to education * educational mobility * educational inequality Subject RIV: AO - Sociology, Demography Impact factor: 0.562, year: 2009

  10. Průniky hudebních a cizojazyčných dovedností u dětí předškolního věku (z hlediska soudobých proměn vzdělávání)

    OpenAIRE

    Píclová, Olga

    2010-01-01

    The Thesis is a continuation of the bachelor thesis "Acquisition of foreign-language experience through the integration of musical activities in preschool children." It focuses on language propaedeutic of children in kindergartens. The obtaining of foreign language skills in preschool age has the form of integrated education with corresponding psychological aspects. The Thesis characterizes psychology of training of obtaining foreign language skills of preschool children. It verifies experime...

  11. Kulturní proměny na přelomu doby kamenné a bronzové na Moravě a mimo ni ve světle kamenné štípané industrie

    Czech Academy of Sciences Publication Activity Database

    Šebela, Lubomír

    2016-01-01

    Roč. 57, č. 1 (2016), s. 87-121 ISSN 1211-7250 Institutional support: RVO:68081758 Keywords : Moravia * turn of the Stone and Bronze Ages * chipped stone industries * cultural transformations * genesis of the Bronze Age Subject RIV: AC - Archeology, Anthropology, Ethnology http://arub.avcr.cz/miranda2/export/sitesavcr/arub/prehled-vyzkumu/prehled-vydanych-cisel/files/PV-57-1_sebela.pdf

  12. Analýza vztahu náboženského vyznání a plodnosti ve Sčítání lidu 2011 (se zařazením vlivu dalších proměnných)

    Czech Academy of Sciences Publication Activity Database

    Růžičková, Markéta; Hamplová, Dana

    2016-01-01

    Roč. 58, č. 3 (2016), s. 213-229 ISSN 0011-8265 R&D Projects: GA ČR(CZ) GA14-15008S; GA ČR GB14-36154G Institutional support: RVO:68378025 Keywords : religious belief * fertility * census Subject RIV: AO - Sociology, Demography

  13. Počátkové českého básnictví a německá metrika. K proměnám českého verše v nadnárodním kontextu

    Czech Academy of Sciences Publication Activity Database

    Dobiáš, Dalibor

    2012-01-01

    Roč. 60, č. 3 (2012), s. 355-367 ISSN 0009-0468 Institutional support: RVO:68378068 Keywords : Czech literature * history of Czech verse * Czech National Revival Subject RIV: AJ - Letters, Mass-media, Audiovision

  14. Proměny českého chorálu v 16. století - pokus o klasifikaci redakcí českého chorálu 16. století na příkladu aleluja ke svátku Nanebevzetí Panny Marie

    Czech Academy of Sciences Publication Activity Database

    Žůrek, Jiří

    2010-01-01

    Roč. 47, č. 4 (2010), s. 333-350 ISSN 0018-7003 R&D Projects: GA ČR GA401/09/0419 Institutional research plan: CEZ:AV0Z90090514 Keywords : plainchant * Utraquism * liturgical music Subject RIV: AA - Philosophy ; Religion

  15. Proměny v pohřebním ritu jako indikátor změn ve využití zdrojů sociálního prostředí starší doby bronzové

    Czech Academy of Sciences Publication Activity Database

    Limburský, Petr; Koštová, Nikola

    2014-01-01

    Roč. 16, prosinec (2014), s. 53-57 ISSN 1213-1628 R&D Projects: GA ČR GP13-24252P Institutional support: RVO:67985912 Keywords : Early Bronze Age * burial rite * social environment Subject RIV: AC - Archeology, Anthropology, Ethnology

  16. Prediction of Agriculture Drought Using Support Vector Regression Incorporating with Climatology Indices

    Science.gov (United States)

    Tian, Y.; Xu, Y. P.

    2017-12-01

    In this paper, the Support Vector Regression (SVR) model incorporating climate indices and drought indices are developed to predict agriculture drought in Xiangjiang River basin, Central China. The agriculture droughts are presented with the Precipitation-Evapotranspiration Index (SPEI). According to the analysis of the relationship between SPEI with different time scales and soil moisture, it is found that SPEI of six months time scales (SPEI-6) could reflect the soil moisture better than that of three and one month time scale from the drought features including drought duration, severity and peak. Climate forcing like El Niño Southern Oscillation and western Pacific subtropical high (WPSH) are represented by climate indices such as MEI and series indices of WPSH. Ridge Point of WPSH is found to be the key factor that influences the agriculture drought mainly through the control of temperature. Based on the climate indices analysis, the predictions of SPEI-6 are conducted using the SVR model. The results show that the SVR model incorperating climate indices, especially ridge point of WPSH, could improve the prediction accuracy compared to that using drought index only. The improvement was more significant for the prediction of one month lead time than that of three months lead time. However, it needs to be cautious in selection of the input parameters, since adding more useless information could have a counter effect in attaining a better prediction.

  17. Readability of Orthopaedic Patient-reported Outcome Measures: Is There a Fundamental Failure to Communicate?

    Science.gov (United States)

    Perez, Jorge L; Mosher, Zachary A; Watson, Shawna L; Sheppard, Evan D; Brabston, Eugene W; McGwin, Gerald; Ponce, Brent A

    2017-08-01

    Patient-reported outcome measures (PROMs) are increasingly used to quantify patients' perceptions of functional ability. The American Medical Association and NIH suggest patient materials be written at or below 6th to 8th grade reading levels, respectively, yet one recent study asserts that few PROMs comply with these recommendations, and suggests that the majority of PROMs are written at too high of a reading level for self-administered patient use. Notably, this study was limited in its use of only one readability algorithm, although there is no commonly accepted, standard readability algorithm for healthcare-related materials. Our study, using multiple readability equations and heeding equal weight to each, hopes to yield a broader, all-encompassing estimate of readability, thereby offering a more accurate assessment of the readability of orthopaedic PROMS. (1) What proportion of orthopaedic-related PROMs and orthopaedic-related portions of the NIH Patient Reported Outcomes Measurement Information System (PROMIS ® ) are written at or below the 6th and 8th grade levels? (2) Is there a correlation between the number of questions in the PROM and reading level? (3) Using systematic edits based on guidelines from the Centers for Medicare and Medicaid Services, what proportion of PROMs achieved American Medical Association and NIH-recommended reading levels? Eighty-six (86) independent, orthopaedic and general wellness PROMs, drawn from commonly referenced orthopaedic websites and prior studies, were chosen for analysis. Additionally, owing to their increasing use in orthopaedics, four relevant short forms, and 11 adult, physical health question banks from the PROMIS ® , were included for analysis. All documents were analyzed for reading grade levels using 19 unique readability algorithms. Descriptive statistics were performed using SPSS Version 22.0. The majority of the independent PROMs (64 of 86; 74%) were written at or below the 6th grade level, with 81 of 86

  18. Transabdominal amnioinfusion in preterm premature rupture of membranes: a randomised controlled trial.

    Science.gov (United States)

    Tranquilli, Andrea Luigi; Giannubilo, Stefano Raffaele; Bezzeccheri, Valeria; Scagnoli, Caterina

    2005-06-01

    To evaluate the role of transabdominal amnioinfusion in improving the perinatal outcomes of pregnancies complicated by preterm premature rupture of membranes (pPROM). A randomised controlled trial. A teaching hospital in Italy, obstetric unit. Population Women with singleton pregnancies complicated by pPROM, between 24 + 0 and 32 + 6 weeks of gestation. Patients were randomised 24 hours after admission to our referral hospital, to expectant management with transabdominal amnioinfusion or expectant management only. The effects of transabdominal amnioinfusion on pPROM-delivery interval and on perinatal outcomes. Of the 65 women with pPROM 34 met the inclusion criteria. Seventeen women were assigned to amnioinfusion (the amnioinfusion group) and the other 17 to expectant management. Compared with the control group (median: 8 days; range: 3-14), the pPROM-delivery period was significantly longer in women who underwent amnioinfusion (median: 21 days; range: 15-29) (P amnioinfusion were less likely to deliver within seven days since pPROM (RR: 0.18; range: 0.04-0.69 95% CI) or within two weeks (RR: 0.46; range: 0.21-1.02 95% CI). In the amnioinfusion group the neonatal survival was significantly higher at each gestational age (P amnioinfusion after pPROM resulted in significant prolongation of pregnancy and better neonatal outcomes.

  19. Vaginal Fluid hCG Levels for Detecting Premature Rupture of Membranes

    Directory of Open Access Journals (Sweden)

    T. Artimani

    2004-04-01

    Full Text Available The aim of this study was to determine whether there is any different in hCG levels of vaginal fluids from normal pregnant women, women with confirmed PROM and with suspected PROM. After irrigating the posterior vaginal fornix with 3 ml of sterile saline and procuring vaginal washing , we measured hCG levels. Samples were analyzed from 38 normal pregnant women , 31 women with confirmed PROM , 28 women with suspected PROM. The mean of vaginal fluid hCG levels of normal pregnant women were 11.2 (0.00-98.6 mIu/ml. That of women with PROM was 140.2 (0.5 , 390.1 and that of women with suspected PROM was 21.5 (0.0 , 143.9. Sensivity was 80%, specility 83% , positive predictive value 73.7% , negative predictive value 88.1% , using a cut-value 20. It was concluded that the hCG level in vaginal fluid is a marker of PROM during third trimester.

  20. Added Value of Patient-Reported Outcome Measures in Stroke Clinical Practice.

    Science.gov (United States)

    Katzan, Irene L; Thompson, Nicolas R; Lapin, Brittany; Uchino, Ken

    2017-07-21

    There is uncertainty regarding the clinical utility of the data obtained from patient-reported outcome measures (PROMs) for patient care. We evaluated the incremental information obtained by PROMs compared to the clinician-reported modified Rankin Scale (mRS). This was an observational study of 3283 ischemic stroke patients seen in a cerebrovascular clinic from September 14, 2012 to June 16, 2015 who completed the routinely collected PROMs: Stroke Impact Scale-16 (SIS-16), EQ-5D, Patient Health Questionnaire-9, PROMIS Physical Function, and PROMIS fatigue. The amount of variation in the PROMs explained by mRS was determined using r 2 after adjustment for age and level of stroke impairment. The proportion with meaningful change was calculated for patients with ≥2 visits. Concordance with change in the other scales and the ability to discriminate changes in health state as measured by c-statistic was evaluated for mRS versus SIS-16. Correlation between PROMs and mRS was highest for SIS-16 ( r =-0.64, P measures. PROMs provide additional valuable information compared to the mRS alone in stroke patients seen in the ambulatory setting. SIS-16 may have a better ability to identify change than mRS in health status of relevance to the patient. PROMs may be a useful addition to mRS in the assessment of health status in clinical practice. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

  1. Expectations of younger patients concerning activities after knee arthroplasty: are we asking the right questions?

    Science.gov (United States)

    Witjes, Suzanne; van Geenen, Rutger C I; Koenraadt, Koen L M; van der Hart, Cor P; Blankevoort, Leendert; Kerkhoffs, Gino M M J; Kuijer, P Paul F M

    2017-02-01

    Indications for total and unicondylar knee arthroplasty (KA) have expanded to younger patients, in which Patient-Reported Outcome Measures (PROMs) often show ceiling effects. This might be due to higher expectations. Our aims were to explore expectations of younger patients concerning activities in daily life, work and leisure time after KA and to assess to what extent PROMs meet and evaluate these activities of importance. Focus groups were performed among osteoarthritis (OA) patients leisure time after KA. Additionally, 28 activities of daily life, 17 of work and 27 of leisure time were depicted from seven PROMS, which were rated on importance, frequency and bother. A total score, representing motivation for surgery, was also calculated. Data saturation was reached after six focus groups including 37 patients. Younger OA patients expect to perform better on 16 activities after KA, including high-impact leisure time activities. From the PROMs, daily life and work activities were rated high in both importance and motivation for surgery, but for leisure time activities importance varied highly between patients. All seven PROMs score activities of importance, but no single PROM incorporates all activities rated important. Younger patients expect to perform better on many activities of daily life, work and leisure time after KA, and often at demanding levels. To measure outcomes of younger patients, we suggest using PROMs that include work and leisure time activities besides daily life activities, in which preferably scored activities can be individualized.

  2. The impact of tobacco use on preterm premature rupture of the membranes.

    Science.gov (United States)

    Andres, Robert L; Zhao, Yuan; Klebanoff, Mark A; Hauth, John C; Caritis, Steve N; Carey, J Christopher; Wapner, Ronald J; Iams, Jay D; Leveno, Kenneth J; Miodovnik, Menachem; Sibai, Baha; Van Dorsten, J Peter; Dombrowski, Mitchell P; O'Sullivan, Mary J; Langer, Oded

    2013-03-01

    To determine if tobacco use increases the incidence of preterm premature rupture of the membranes (pPROM) or alters perinatal outcomes after pPROM. This is a secondary analysis of the databases of three completed Eunice Kennedy Shriver National Institute of Child Health and Human Development-supported Maternal Fetal Medicine Units Network studies. Self-reported tobacco exposure data was obtained. Its relationship with the incidence of pPROM and associated neonatal outcome measures were assessed. There was no difference in the incidence of pPROM when comparing nonsmokers to those using tobacco. Although a trend was seen between the incidence of pPROM and the amount smoked, this did not reach statistical significance. Among the patients with pPROM, the use of tobacco was not associated with an increase in perinatal morbidity. Our data do not support a significant relationship between tobacco use and pPROM. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  3. Tipping point of a conifer forest ecosystem under severe drought

    International Nuclear Information System (INIS)

    Huang, Kaicheng; Zhou, Tao; Wu, Hao; Ling, Du; Li, Zheng; Yi, Chuixiang; Blanford, William J; Wei, Suhua; Wu, Donghai; Zhao, Xiang

    2015-01-01

    Drought-induced tree mortality has recently received considerable attention. Questions have arisen over the necessary intensity and duration thresholds of droughts that are sufficient to trigger rapid forest declines. The values of such tipping points leading to forest declines due to drought are presently unknown. In this study, we have evaluated the potential relationship between the level of tree growth and concurrent drought conditions with data of the tree growth-related ring width index (RWI) of the two dominant conifer species (Pinus edulis and Pinus ponderosa) in the Southwestern United States (SWUS) and the meteorological drought-related standardized precipitation evapotranspiration index (SPEI). In this effort, we determined the binned averages of RWI and the 11 month SPEI within the month of July within each bin of 30 of RWI in the range of 0–3000. We found a significant correlation between the binned averages of RWI and SPEI at the regional-scale under dryer conditions. The tipping point of forest declines to drought is predicted by the regression model as SPEI tp  = −1.64 and RWI tp  = 0, that is, persistence of the water deficit (11 month) with intensity of −1.64 leading to negligible growth for the conifer species. When climate conditions are wetter, the correlation between the binned averages of RWI and SPEI is weaker which we believe is most likely due to soil water and atmospheric moisture levels no longer being the dominant factor limiting tree growth. We also illustrate a potential application of the derived tipping point (SPEI tp  = −1.64) through an examination of the 2002 extreme drought event in the SWUS conifer forest regions. Distinguished differences in remote-sensing based NDVI anomalies were found between the two regions partitioned by the derived tipping point. (letter)

  4. Spatiotemporal Drought Analysis and Drought Indices Comparison in India

    Science.gov (United States)

    Janardhanan, A.

    2017-12-01

    Droughts and floods are an ever-occurring phenomenon that has been wreaking havoc on humans since the start of time. As droughts are on a very large scale, studying them within a regional context can minimize confounding factors such as climate change. Droughts and floods are extremely erratic and very difficult to predict and therefore necessitate modeling through advanced statistics. The SPI (Standard Precipitation Index) and the SPEI (Standard Precipitation Evapotranspiration Index) are two ways to temporally model drought and flood patterns across each metrological sub basin in India over a variety of different time scales. SPI only accounts for precipitation values, while the SPEI accounts for both precipitation and temperature and is commonly regarded as a more reliable drought index. Using monthly rainfall and temperature data from 1871-2016, these two indices were calculated. The results depict the drought and flood severity index, length of drought, and average SPI or SPEI value for each meteorological sub region in India. A Wilcox Ranksum test was then conducted to determine whether these two indices differed over the long term for drought analysis. The drought return periods were analyzed to determine if the population mean differed between the SPI and SPEI values. Our analysis found no statistical difference between SPI and SPEI with regards to long-term drought analysis. This indicates that temperature is not needed when modeling drought on a long-term time scale and that SPI is just as effective as SPEI, which has the potential to save a lot of time and resources on calculating drought indices.

  5. Using patient reported outcome measures in health services: A qualitative study on including people with low literacy skills and learning disabilities

    Directory of Open Access Journals (Sweden)

    Jahagirdar Deepa

    2012-11-01

    Full Text Available Abstract Background Patient reported outcome measures (PROMs are self-report measures of health status increasingly promoted for use in healthcare quality improvement. However people with low literacy skills or learning disabilities may find PROMs hard to complete. Our study investigated stakeholder views on the accessibility and use of PROMs to develop suggestions for more inclusive practice. Methods Taking PROMs recommended for chronic obstructive pulmonary disease (COPD as an example, we conducted 8 interviews with people with low literacy skills and/or learning disabilities, and 4 focus groups with 20 health professionals and people with COPD. Discussions covered the format and delivery of PROMs using the EQ-5D and St George Respiratory Questionnaire as prompts. Thematic framework analysis focused on three main themes: Accessibility, Ease of Use, and Contextual factors. Results Accessibility included issues concerning the questionnaire format, and suggestions for improvement included larger font sizes and more white space. Ease of Use included discussion about PROMs’ administration. While health professionals suggested PROMs could be completed in waiting rooms, patients preferred settings with more privacy and where they could access help from people they know. Contextual Factors included other challenges and wider issues associated with completing PROMs. While health professionals highlighted difficulties created by the system in managing patients with low literacy/learning disabilities, patient participants stressed that understanding the purpose of PROMs was important to reduce intimidation. Conclusions Adjusting PROMs’ format, giving an explicit choice of where patients can complete them, and clearly conveying PROMs’ purpose and benefit to patients may help to prevent inequality when using PROMs in health services.

  6. C-REACTIVE PROTEIN IN PREMATURE RUPTURE OF MEMBRANE WITH RESPECT TO FETOMATERNAL OUTCOME

    Directory of Open Access Journals (Sweden)

    Ojaswini Patel

    2017-08-01

    Full Text Available BACKGROUND The incidence of PROM is about 10% of all pregnancies and 70% of them occur at term. Most of the Indian studies document an incidence of 7-12% for PROM of which 60-70% occurs at term. Rest of the 30-40% is contributed at preterm. The aim of the study is to study the usefulness of maternal CRP measurements in diagnosis of chorioamnionitis, puerperal endometritis, neonatal infectious morbidities and mortalities among patients with PROM ( both term and preterm. MATERIALS AND METHODS This is a hospital-based cross-sectional observational study where 100 premature rupture of membrane cases were diagnosed and observed for fetomaternal outcome by doing routine clinical, biochemical and serum CRP examinations. RESULTS Maximum number of chorioamnionitis (16% has developed when duration of rupture was for more than 36 hrs. PROM patients with latent period of ≥36 hrs had poorer neonatal outcome; i.e. 54.83% neonatal morbidity and 84.61% neonatal mortality were seen when duration of rupture was more than 36 hrs. 47.36% of CRP positive PROM women had developed chorioamnionitis during the course of delivery or postpartum. 49.12% of CRP positive PROM women had developed preterm delivery. CRP positive PROM women had poorer neonatal outcome; i.e. 82.35% neonatal morbidity and mortality has noted in babies delivered from CRP positive mother. CONCLUSION Careful antenatal monitoring, detection and prompt treatment of infection is necessary. Strict aseptic precautions, appropriate therapy, regular antenatal follow up are important features in the prevention and management of PROM. Evaluation of CRP in blood has helped to predict development of chorioamnionitis and preterm delivery following PROM and also perinatal morbidity and mortality.

  7. Large scale circulation patterns associated to seasonal dry and wet conditions over the Czech Republic

    OpenAIRE

    Boroneant, Constanta; Potop, Vera; Mozny, Martin; Stepanek, Petr; Skalak, Petr

    2012-01-01

    Ponencia presentada en: VIII Congreso de la Asociación Española de Climatología celebrado en Salamanca entre el 25 y el 28 de septiembre de 2012. [ES]Este trabajo analiza la relación entre las condiciones estaciónales extremadamente secas y húmedas en la República Checa y los patrones de circulación de gran escala. El índice estandarizado de precipitación y evapotranspiración (SPEI) se utiliza para cuantificar las condiciones de humedad. El SPEI fue calculado a partir de los regis...

  8. High-density cervical ureaplasma urealyticum colonization in pregnant women

    Directory of Open Access Journals (Sweden)

    Ranđelović Gordana

    2006-01-01

    Full Text Available Background/aim: Ureaplasma urealyticum, a common commensal of the female lower genital tract, has been observed as an important opportunistic pathogen during pregnancy. The aims of this study were to determine the degree of cervical colonization with U. urealyticum in pregnant women with risk pregnancy and in pregnant women with normal term delivery and to evaluate the correlation between high-density cervical U. urealyticum colonization and premature rupture of membranes (PROM as well. Methods. This research was conducted on the samples comprising 130 hospitalized pregnant women with threatening preterm delivery and premature rupture of membranes. The control group consisted of 39 pregnant women with term delivery without PROM. In addition to standard bacteriological examination and performing direct immunofluorescence test to detect Chlamydia trachomatis, cervical swabs were also examined for the presence of U. urealyticum and Mycoplasma hominis by commercially available Mycofast Evolution 2 test (International Microbio, France. Results. The number of findings with isolated high-density U. urealyticum in the target group was 69 (53.08%, while in the control group was 14 (35.90%. Premature rupture of membranes (PROM occurred in 43 (33.08% examinees: 29 were pPROM, and 14 were PROM. The finding of U.urealyticum ≥104 was determined in 25 (58.14% pregnant women with rupture, 17 were pPROM, and 8 were PROM. There was statistically significant difference in the finding of high-density U. urealyticum between the pregnant women with PROM and the control group (χ² = 4.06, p < 0.05. U. urealyticum was predominant bacterial species found in 62.79% of isolates in the PROM cases, while in 32.56% it was isolated alone. Among the 49 pregnant women with preterm delivery, pPROM occurred in 29 (59.18% examinees, and in 70.83% of pregnant women with findings of high-density U. urealyticum pPROM was observed. Conclusion. Cervical colonization with U

  9. Udvikling og validering af patientrapporterede spørgeskemaer – del 2

    DEFF Research Database (Denmark)

    Willert, Cecilie Balslev; Hölmich, Lisbet Rosenkrantz; Thorborg, Kristian

    2015-01-01

    Test Theory and Item Response Theory, psychometric validation and the measurement properties of a PROM. The latter is based on the COSMIN (consensus-based standards for the selection of health measurement instruments) guidelines, which are developed to assist in development and evaluation of PROMs.......Patient-reported outcome measurements (PROMs) are often questionnaires which provide and rate the patient's point of view in the measurement of subjective clinical phenomena such as pain or quality of life. In the second of two articles we describe field-testing, the psychometric theories Classical...

  10. 8 May 2014 - W. Watson-Wright, Assistant Director General and Executive Secretary UNESCO Intergovernmental Oceanographic Commission Assistant Director-General for the Natural Sciences Sector ad interim visiting the CMS cavern with CMS Collaboration Deputy Spkokesperson K. Borras. Adviser to the Director-General, in charge of Relations with International Organisations M. Bona present throughout.

    CERN Multimedia

    Brice, Maximilien

    2014-01-01

    Ms Wendy Watson-Wright Assistant Director General and Executive Secretary UNESCO Intergovernmental Oceanographic Commission Assistant Director-General for the Natural Sciences Sector ad interim UNESCO

  11. Muusikamaailm / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2011-01-01

    Muusikasõnumeid mujalt maailmast: BBC Proms - maailma suurim muusikafestival. Arvo Pärdi "Vater unser" kõlas kingitusena paavstile. Lera Auerbachi muusika on jätkuvalt menukas. Preemiaid ja tunnustusi

  12. Austusavaldus Puccinile / Silja Joon

    Index Scriptorium Estoniae

    Joon, Silja, 1966-

    2008-01-01

    Puccini galakontserdist Pärnu rahvusvahelise ooperimuusika festivali PromFest raames 15. mail Endla teatris ja 16. mail Tallinnas Vene teatris (laval rahvusvahelise Klaudia Taevi konkursi võitjad läbi aegade)

  13. Noored tähed Puccinile pühendatud galaõhtul Endlas / Toomas Kuter

    Index Scriptorium Estoniae

    Kuter, Toomas, 1965-

    2008-01-01

    Puccini galakontserdist Pärnu rahvusvahelise ooperimuusika festivali PromFest raames 15. mail Endla teatris ja 16. mail Tallinnas Vene teatris (laval rahvusvahelise Klaudia Taevi konkursi võitjad läbi aegade)

  14. Peer Pressure

    Science.gov (United States)

    ... for: Teens Dealing With Bullying Emotional Intelligence Sexual Harassment and Sexual Bullying Coping With Stressful Situations Prom Pressure What Stresses You Out About School? Virginity: A Very Personal Decision Stress & Coping Center ...

  15. Patient-reported outcome measures in arthroplasty registries

    DEFF Research Database (Denmark)

    Rolfson, Ola; Bohm, Eric; Franklin, Patricia

    2016-01-01

    The International Society of Arthroplasty Registries (ISAR) Patient-Reported Outcome Measures (PROMs) Working Group have evaluated and recommended best practices in the selection, administration, and interpretation of PROMs for hip and knee arthroplasty registries. The 2 generic PROMs in common use...... are the Short Form health surveys (SF-36 or SF-12) and EuroQol 5-dimension (EQ-5D). The Working Group recommends that registries should choose specific PROMs that have been appropriately developed with good measurement properties for arthroplasty patients. The Working Group recommend the use of a 1-item pain...... should consider the absolute level of pain, function, and general health status as well as improvement, missing data, approaches to analysis and case-mix adjustment, minimal clinically important difference, and minimal detectable change. The Working Group recommends data collection immediately before...

  16. Endlas etendub lugu mungast ja kurtisaanist / Silja Joon

    Index Scriptorium Estoniae

    Joon, Silja, 1966-

    2008-01-01

    Rahvusvahelise ooperimuusika festivali PromFest raames järgmise aasta 22. mail Pärnu teatris Endla esietenduvast Jules Massenet' ooperist "Thais" (peaosades eelmise Klaudia Taevi nimelise konkursi laureaadid Veronika Dzhiojeva ja Ilja Siltshukov)

  17. High MMP-9 and TNF-α expression increase in preterm premature rupture of membranes

    Directory of Open Access Journals (Sweden)

    Sri Sulistyowati

    2016-05-01

    Expression of MMP-9 and TNF-α was higher in the amniotic membrane of preterm delivery subjects with PROM than in preterm delivery subjects without PROM and can thus be used as predictor to avoid PPROM.

  18. Outcomes of preterm premature rupture of membranes in twin pregnancies.

    Science.gov (United States)

    Trentacoste, Stephanie V; Jean-Pierre, Claudel; Baergen, Rebecca; Chasen, Stephen T

    2008-08-01

    To describe outcomes in twin pregnancies with preterm premature rupture of membranes (PPROM). Dichorionic twin pregnancies complicated by PPROM at premature rupture of membranes (PROM), latency from PROM to delivery, and infection were examined. In 49 twin pregnancies, the median gestational age at PROM was 31 weeks with a median latency between PROM and delivery of 0 days (interquartile range 0-6). Latency intervals of >or=2 and >or=7 days were achieved by 40.8% and 22.4%, respectively. PPROM at or= 2 days (70.6% vs. 25.0%) and >or=7 days (47.1% vs. 9.4%). There was a significant relationship between latency and clinical and histologic signs of infection. After 30 weeks, most twin pregnancies with PPROM delivered within 2 days. Infection appears to be a consequence rather than a cause of PPROM in most cases.

  19. Outcome of Induction and Associated Factors among Term and Post

    African Journals Online (AJOL)

    GB

    354 records ... The purpose of this study was to analyze outcome of induction with ... (PROM), post-term pregnancy, maternal medical ... restriction, iso-immunization), preeclampsia, and .... provides services for approximately 9000 inpatient.

  20. Measurement properties of the most commonly used Foot- and Ankle-Specific Questionnaires: the FFI, FAOS and FAAM. A systematic review.

    Science.gov (United States)

    Sierevelt, I N; Zwiers, R; Schats, W; Haverkamp, D; Terwee, C B; Nolte, P A; Kerkhoffs, G M M J

    2017-10-12

    In the foot and ankle literature, a wide range of patient-reported outcome measures (PROMs) is used, however, consensus as to which PROMs are preferred is lacking. Selection of a PROM is among other reasons, often based on measurement properties without considering the methodological quality of the studies that evaluate these measurement properties. The aim of current study was first to identify the most frequently used foot and ankle-specific PROMs in recent orthopaedic foot and ankle literature, and second to conduct a systematic review to synthesize and critically appraise the measurement properties of these PROMS. Six PubMed indexed journals focussing on foot and ankle research were screened to identify most commonly used foot and ankle-specific PROMs over a 2 year period (2015-2016). Subsequently, a systematic literature search was performed in PubMed, EMBASE, SPORTDiscus and Scopus to identify relevant studies on their measurement properties. Methodological quality assessment was performed using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist, criteria for good measurement properties were applied, and a level of evidence was determined for the measurement properties of each domain of the questionnaires. The three most frequently reported PROMs were the Foot Function Index (FFI), the Foot and Ankle Outcome Score (FAOS) and the Foot and Ankle Activity Measure (FAAM). Among 2046 unique citations, 50 studies were included evaluating these PROMs. Evidence to support the measurement properties of the FFI was mainly lacking due to poor methodological quality. More evidence was available for the measurement properties of the FAOS and the FAAM, but overall evidence supporting all measurement properties is not yet sufficient. The best available evidence retrieved in this review showed that the FAOS and the FAAM are promising outcome measures for evaluation of patients with foot and ankle conditions, but their

  1. Measurement of Prosocial Reasoning among Chinese Adolescents

    OpenAIRE

    Frank H. Y. Lai; Andrew M. H. Siu; Chewtyn C. H. Chan; Daniel T. L. Shek

    2012-01-01

    This study attempted to develop a standardized instrument for assessment of prosocial reasoning in Chinese populations. The Prosocial Reasoning Objective Measure (PROM) was translated, and a two-stage study was conducted to evaluate the psychometric properties of the translated instrument. The content validity, cultural relevance, and reading level of the translated instrument were evaluated by an expert panel. Upon revisions according to the expert opinions, the Chinese PROM demonstrated goo...

  2. Comparison of induced labour pattern in women with premature rupture of membranes at term and those with intact membranes

    Directory of Open Access Journals (Sweden)

    J A Osaikhuwuomwan

    2011-01-01

    Conclusion: The finding of a significant shorter latent period, requirement for less oxytocin dose and overall shorter duration of stimulated labour cases with PROM compared to induction of labour for those with intact membranes suggest that PROM may be a means of labour initiation by some parturients and thus implies that these two groups of paturients are different obstetric entities and should therefore be treated as such in their labour management and research consideration.

  3. The extreme European summer of 2015 in a long-term perspective

    Czech Academy of Sciences Publication Activity Database

    Hoy, A.; Hänsel, S.; Skalák, Petr; Ustrnul, Z.; Bochníček, O.

    2017-01-01

    Roč. 37, č. 2 (2017), s. 943-962 ISSN 0899-8418 R&D Projects: GA MŠk(CZ) LO1415 Institutional support: RVO:67179843 Keywords : Climate indices * Drought * Heat * mRAI * SPEI * SPI * WBAI Subject RIV: EH - Ecology, Behaviour OBOR OECD: Environmental sciences (social aspects to be 5.7) Impact factor: 3.760, year: 2016

  4. Comparison of Pseudomonas aeruginosa isolates from mink by serotyping and pulsed-field gel electrophoresis

    DEFF Research Database (Denmark)

    Hammer, Anne Sofie; Pedersen, Karl; Andersen, Thomas Holmen

    2003-01-01

    Isolates of Pseudomonas aeruginosa from clinical infections in mink were subjected to serotyping and pulsed-field gel electrophoresis (PFGE) using SpeI. A total of 212 isolates of P aeruginosa from the year 1998 to 2001 were included in this study: 168 isolates from mink obtained from 74 farm out...

  5. Drought variability and change across the Iberian Peninsula

    Science.gov (United States)

    Coll, J. R.; Aguilar, E.; Ashcroft, L.

    2017-11-01

    Drought variability and change was assessed across the Iberian Peninsula over more than 100 years expanding through the twentieth century and the first decade of the twenty-first century. Daily temperature and precipitation data from 24 Iberian time series were quality controlled and homogenized to create the Monthly Iberian Temperature and Precipitation Series (MITPS) for the period 1906-2010. The Standardized Precipitation Index (SPI), driven only by precipitation, and the Standardized Precipitation Evapotranspiration Index (SPEI), based on the difference between the precipitation and the reference evapotranspiration (ET0), were computed at annual and seasonal scale to describe the evolution of droughts across time. The results confirmed that a clear temperature increase has occurred over the entire Iberian Peninsula at the annual and seasonal scale, but no significant changes in precipitation accumulated amounts were found. Similar drought variability was provided by the SPI and SPEI, although the SPEI showed greater drought severity and larger surface area affected by drought than SPI from 1980s to 2010 due to the increase in atmospheric evaporative demand caused by increased temperatures. Moreover, a clear drying trend was found by the SPEI for most of the Iberian Peninsula at annual scale and also for spring and summer, although the SPI did not experience significant changes in drought conditions. From the drying trend identified for most of the Iberian Peninsula along the twentieth century, an increase in drought conditions can also be expected for this region in the twenty-first century according to future climate change projections and scenarios.

  6. Performance of the standardised precipitation evapotranspiration index at various lags for agricultural drought risk assessment in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Potopová, V.; Štěpánek, Petr; Možný, M.; Türkot, L.; Soukup, J.

    2015-01-01

    Roč. 202, mar 15 (2015), s. 262-38 ISSN 0168-1923 R&D Projects: GA MŠk(CZ) EE2.3.20.0248 Institutional support: RVO:67179843 Keywords : multi-scale drought * wet * SPEI * SYRS * Yield crops Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 4.461, year: 2015

  7. Assessments of Drought Impacts on Vegetation in China with the Optimal Time Scales of the Climatic Drought Index

    Directory of Open Access Journals (Sweden)

    Zheng Li

    2015-07-01

    Full Text Available Drought is expected to increase in frequency and severity due to global warming, and its impacts on vegetation are typically extensively evaluated with climatic drought indices, such as multi-scalar Standardized Precipitation Evapotranspiration Index (SPEI. We analyzed the covariation between the SPEIs of various time scales and the anomalies of the normalized difference vegetation index (NDVI, from which the vegetation type-related optimal time scales were retrieved. The results indicated that the optimal time scales of needle-leaved forest, broadleaf forest and shrubland were between 10 and 12 months, which were considerably longer than the grassland, meadow and cultivated vegetation ones (2 to 4 months. When the optimal vegetation type-related time scales were used, the SPEI could better reflect the vegetation’s responses to water conditions, with the correlation coefficients between SPEIs and NDVI anomalies increased by 5.88% to 28.4%. We investigated the spatio-temporal characteristics of drought and quantified the different responses of vegetation growth to drought during the growing season (April–October. The results revealed that the frequency of drought has increased in the 21st century with the drying trend occurring in most of China. These results are useful for ecological assessments and adapting management steps to mitigate the impact of drought on vegetation. They are helpful to employ water resources more efficiently and reduce potential damage to human health caused by water shortages.

  8. Drought trends over part of Central Europe between 1961 and 2014

    Czech Academy of Sciences Publication Activity Database

    Trnka, Miroslav; Balek, Jan; Štěpánek, Petr; Zahradníček, Pavel; Možný, M.; Eitzinger, Josef; Žalud, Zdeněk; Formayer, H.; Turňa, M.; Nejedlík, P.; Semerádová, Daniela; Hlavinka, Petr; Brázdil, Rudolf

    2016-01-01

    Roč. 70, oct (2016), s. 143-160 ISSN 0936-577X R&D Projects: GA MŠk(CZ) LO1415; GA ČR GA13-04291S Institutional support: RVO:67179843 Keywords : SPI * PDSI * SPEI * Z-index * ICDI * Drought climatology * Climate trends Subject RIV: EH - Ecology, Behaviour Impact factor: 1.578, year: 2016

  9. Readability Level of Spanish-Language Patient-Reported Outcome Measures in Audiology and Otolaryngology

    Science.gov (United States)

    Coco, Laura; Colina, Sonia; Atcherson, Samuel R.

    2017-01-01

    Purpose The purpose of this study was to examine the readability level of the Spanish versions of several audiology- and otolaryngology-related patient-reported outcome measures (PROMs) and include a readability analysis of 2 translation approaches when available—the published version and a “functionalist” version—using a team-based collaborative approach including community members. Method Readability levels were calculated using the Fry Graph adapted for Spanish, as well as the Fernandez-Huerta and the Spaulding formulae for several commonly used audiology- and otolaryngology-related PROMs. Results Readability calculations agreed with previous studies analyzing audiology-related PROMs in English and demonstrated many Spanish-language PROMs were beyond the 5th grade reading level suggested for health-related materials written for the average population. In addition, the functionalist versions of the PROMs yielded lower grade-level (improved) readability levels than the published versions. Conclusion Our results suggest many of the Spanish-language PROMs evaluated here are beyond the recommended readability levels and may be influenced by the approach to translation. Moreover, improved readability may be possible using a functionalist approach to translation. Future analysis of the suitability of outcome measures and the quality of their translations should move beyond readability and include an evaluation of the individual's comprehension of the written text. PMID:28892821

  10. Measurement of Prosocial Reasoning among Chinese Adolescents

    Directory of Open Access Journals (Sweden)

    Frank H. Y. Lai

    2012-01-01

    Full Text Available This study attempted to develop a standardized instrument for assessment of prosocial reasoning in Chinese populations. The Prosocial Reasoning Objective Measure (PROM was translated, and a two-stage study was conducted to evaluate the psychometric properties of the translated instrument. The content validity, cultural relevance, and reading level of the translated instrument were evaluated by an expert panel. Upon revisions according to the expert opinions, the Chinese PROM demonstrated good content validity, “good-to-very good test-retest” reliability, and internal consistency. However, only partial support to the convergent validity of the Chinese PROM was found. In the first stage of the study (=50, the PROM scores had high positive correlations with empathy and negative correlations with personal distress and fantasy. These results were consistent with theoretical expectations, although this is also a concern that empathy had a close-to-unity correlation with PROM score in the small sample study of stage 1. In the second stage of the study (=566, the relationship between PROM scores and prosocial behavior appeared to be weak. Results suggest that there were many personal, family, or social factors that were linked to prosocial behavior, and prosocial reasoning might only contribute to a small proportion of variation in prosocial behavior among adolescents.

  11. Event-Based Prospective Memory Is Resistant but Not Immune to Proactive Interference.

    Science.gov (United States)

    Oates, Joyce M; Peynircioglu, Zehra F

    2016-01-01

    Recent evidence suggests that proactive interference (PI) does not hurt event-based prospective memory (ProM) the way it does retrospective memory (RetroM) (Oates, Peynircioglu, & Bates, 2015). We investigated this apparent resistance further. Introduction of a distractor task to ensure we were testing ProM rather than vigilance in Experiment 1 and tripling the number of lists to provide more opportunity for PI buildup in Experiment 2 still did not produce performance decrements. However, when the ProM task was combined with a RetroM task in Experiment 3, a comparable buildup and release was observed also in the ProM task. It appears that event based ProM is indeed somewhat resistant to PI, but this resistance can break down when the ProM task comprises the same stimuli as in an embedded RetroM task. We discuss the results using the ideas of cue overload and distinctiveness as well as shared attentional and working memory resources.

  12. Measurement of prosocial reasoning among Chinese adolescents.

    Science.gov (United States)

    Lai, Frank H Y; Siu, Andrew M H; Chan, Chewtyn C H; Shek, Daniel T L

    2012-01-01

    This study attempted to develop a standardized instrument for assessment of prosocial reasoning in Chinese populations. The Prosocial Reasoning Objective Measure (PROM) was translated, and a two-stage study was conducted to evaluate the psychometric properties of the translated instrument. The content validity, cultural relevance, and reading level of the translated instrument were evaluated by an expert panel. Upon revisions according to the expert opinions, the Chinese PROM demonstrated good content validity, "good-to-very good test-retest" reliability, and internal consistency. However, only partial support to the convergent validity of the Chinese PROM was found. In the first stage of the study (n = 50), the PROM scores had high positive correlations with empathy and negative correlations with personal distress and fantasy. These results were consistent with theoretical expectations, although this is also a concern that empathy had a close-to-unity correlation with PROM score in the small sample study of stage 1. In the second stage of the study (n = 566), the relationship between PROM scores and prosocial behavior appeared to be weak. Results suggest that there were many personal, family, or social factors that were linked to prosocial behavior, and prosocial reasoning might only contribute to a small proportion of variation in prosocial behavior among adolescents.

  13. The accuracy of placental alpha-microglobuline-1 test in diagnosis of premature rupture of the membranes

    Directory of Open Access Journals (Sweden)

    Maryam Khooshideh

    2015-06-01

    Full Text Available Background: Premature rupture of membranes (PROM is a common obstetric issue during pregnancy which might lead to serious fetal or maternal problems. Therefore, an appropriate diagnosis and management of PROM are of significant importance in patients. Objective: The aim of this study was to determine the accuracy of placental alpha microglobuline-1 (PAMG-1 test in PROM diagnosis and compare this diagnostic method with other standard tests in diagnosis of PROM. Materials and Methods: In this prospective diagnostic accuracy study, patients with symptoms of membrane rupture in 16-39 weeks of gestation were involved. Three tests including Fern, Nitrazine and PAMG-1 were performed at the same time. Results: PROM was confirmed in 86 patients out of 100. The sensitivity and specificity were respectively 81.3% and 100% for Fern test, 93% and 92.8% for Nitrazine test, 98.9% and 92.8% for PAMG-1 test. PAMG-1 test showed higher sensitivity (98.9% with p<0.001 and accuracy (98% compared with conventional tests. Although PAMG-1showed a lower positive predictive value (PPV compared to conventional tests such as Fern test (100%, it was shown to be more accurate. Conclusion: The accuracy of PAMG-1 test was superior to both Fern and Nitrazine test in PROM diagnosis.

  14. Non-invasively collected amniotic fluid as a source of possible biomarkers for premature rupture of membranes investigated by proteomic approach.

    Science.gov (United States)

    Consonni, Sara; Mainini, Veronica; Pizzardi, Agnese; Gianazza, Erica; Chinello, Clizia; Locatelli, Anna; Magni, Fulvio

    2014-02-01

    Preterm delivery is one of the main causes of perinatal morbidity and mortality and it accounts for 75 % of perinatal mortality and more than half of the long-term morbidity. We applied a proteomic approach based on mass spectrometry (MS) for biomarkers discovery of preterm premature rupture of membranes (pPROM) by investigating amniotic fluid (AF) invasively and non-invasively collected. Amniotic fluid was obtained from vagina of women with pPROM (group 1), PROM at term (group 2) and by genetic amniocentesis (group 3). Pre-fractionated AF proteome was analyzed through matrix assisted laser desorption ionization-time of flight (MALDI-TOF) MS. The characterization of proteins/peptides of interest was obtained by high performance liquid chromatography-electrospray tandem MS. Three peptides overexpressed in pPROM and able to discriminate the groups 1 and 2 were detected. One peptide was identified as the fragment Gly452LAVPDGPLGLPPKPro466 of the protein KIAA1522, expressed by fetal brain and liver. This peptide was overexpressed in a patient of the group 3, completely asymptomatic at the time of the amniocentesis, who later developed pPROM. Amniotic fluid invasively and non-invasively collected can be analyzed by MALDI-TOF MS to obtain proteomic profiles. Proteomic analysis identified a peptide with promising diagnostic capability for pPROM.

  15. Polimorfisme Gen MMP-9, Ekspresi MMP-9, dan Indeks Apoptosis Sel Serviks pada Kehamilan 21–36 Minggu

    Directory of Open Access Journals (Sweden)

    Udin Sabarudin

    2011-12-01

    Full Text Available Over expression and premature activation of matrix metalloproteinase (MMP can lead to degradation of amnion chorionic membrane which clinically called premature rupture of membrane (PROM. Increasing MMP activity caused by matrix metalloproteinase-9 (MMP-9 gene polymorphism (C-1562T will be followed by apoptosis. This study was aimed to find the differences between MMP-9 expression and cervical apoptotic index (AI and also MMP-9 (C-1562T polymorphism on 21–36 weeks of pregnancy with or without PROM. This was case control study and conducted in Dr. Hasan Sadikin Hospital and Bandung Networking Hospitals (May−November 2009. There were no significant correlation between MMP-9 expression and cervical AI in every variable on both groups. Three cases of PROM were found in mothers below 20 years of age. Women with 28−34 weeks of pregnancy had a greater risk for PROM than 21−28 weeks. Pregnant women with body mass index (BMI 19−26, had risk to have PROM. Only one sample that showed a MMP-9 (C-1562T polymorphism in the premature labor with PROM group. It can be concluded that there are no significant correlation between MMP-9 expression and cervical cells AI on both groups as well as MMP-9 (C-1562T polymorphism which can alter MMP-9 expression.

  16. Experiment list: SRX190196 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS targe...h repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. (provided by RefSeq) || antibo...rimary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatc

  17. 39 CFR 320.4 - Suspension for certain letters of college and university organizations.

    Science.gov (United States)

    2010-07-01

    ... universities to carry in their internal mail systems the letters of their bona fide student or faculty... university. Colleges and universities choosing to provide their student or faculty organizations access to their internal mail systems are responsible for assuring that only letters of bona fide student or...

  18. 75 FR 55307 - Honey From the People's Republic of China: Preliminary Intent To Rescind New Shipper Reviews

    Science.gov (United States)

    2010-09-10

    ... Shipper Review, 75 FR 38980 (July 7, 2010). Expansion of the POR When the sale of the subject merchandise... review is based on a single sale, exclusion of that sale as non-bona fide necessarily must end the review... Shipper Review of Honey from the People's Republic of China: Bona Fide Analysis of the Sale Under Review...

  19. 76 FR 4289 - Honey From the People's Republic of China: Final Results and Rescission of Antidumping Duty New...

    Science.gov (United States)

    2011-01-25

    ... Fenglian Co., Ltd. (``Fenglian''), the Department finds that that sales under review are not bona fide... Shipper Reviews, 75 FR 55307 (September 10, 2010). Because the sales under review were made during the POR... Republic of China: Bona Fide Analysis of the Sale Under Review for Suzhou Shanding Honey Product Co., Ltd...

  20. 42 CFR 433.67 - Limitations on level of FFP for permissible provider-related donations.

    Science.gov (United States)

    2010-10-01

    ... provider-related donations. 433.67 Section 433.67 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... permissible provider-related donations. (a)(1) Limitations on bona fide donations. There are no limitations on the amount of bona fide provider-related donations that a State may receive without a reduction in FFP...

  1. 19 CFR 10.153 - Conditions for exemption.

    Science.gov (United States)

    2010-04-01

    ... over $200 and Bona Fide Gifts § 10.153 Conditions for exemption. Customs officers shall be further... § 10.151 or § 10.152: (a) A “bona fide gift” for purposes of § 10.152 is an article formerly owned by a... promise of compensation. It does not include articles acquired by purchase, barter, promissory exchange...

  2. Hate Speech Provisions and Provisos: A Response to Marais and ...

    African Journals Online (AJOL)

    MJM Venter

    2017-11-06

    Nov 6, 2017 ... right to freedom of expression and the hate speech limitation in section ... important to take into account that the Act was enacted as a legal means to ...... Films and Publications Act,91 both of which exclude bona fide forms of ..... Likewise, in the context of a bona fide stand-up comedy production, a rude.

  3. 48 CFR 225.7303-4 - Contingent fees.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contingent fees. 225.7303....7303-4 Contingent fees. (a) Except as provided in paragraph (b) of this subsection, contingent fees are generally allowable under DoD contracts, provided— (1) The fees are paid to a bona fide employee or a bona...

  4. 76 FR 24523 - Sun & Lake Pharmacy, Inc.; D/B/A the Medicine Shoppe; Revocation of Registration

    Science.gov (United States)

    2011-05-02

    ... fundamental that a physician practitioner must have established a bona fide doctor-patient relationship in... state law to determine whether a bona fide doctor patient relationship existed.'' Id. at 33-34... issued pursuant to a valid doctor-patient relationship. The ALJ noted that a DEA Diversion Investigator...

  5. 26 CFR 31.3401(a)(6)-1A - Remuneration for services of certain nonresident alien individuals paid before January 1, 1967.

    Science.gov (United States)

    2010-04-01

    ... follows: Sec. 101. Definitions. [Immigration and Nationality Act (66 Stat. 166)] (a) As used in this... has no intention of abandoning, who is a bona fide student qualified to pursue a full course of study... intention of abandoning who is a bona fide student, scholar, trainee, teacher, professor, research assistant...

  6. Office of International Affairs | NSU

    Science.gov (United States)

    Undergraduate Studies Overview Central Administration Administrative Services and Marketing Student Activity Fee valid advance parole and those with a bona fide relationship to a person or entity in the United States foreign nationals who have a credible claim of a bona fide relationship to an entity or person in the

  7. Spatial and temporal analysis of drought variability at several time scales in Syria during 1961-2012

    Science.gov (United States)

    Mathbout, Shifa; Lopez-Bustins, Joan A.; Martin-Vide, Javier; Bech, Joan; Rodrigo, Fernando S.

    2018-02-01

    This paper analyses the observed spatiotemporal characteristics of drought phenomenon in Syria using the Standardised Precipitation Index (SPI) and the Standardised Precipitation Evapotranspiration Index (SPEI). Temporal variability of drought is calculated for various time scales (3, 6, 9, 12, and 24 months) for 20 weather stations over the 1961-2012 period. The spatial patterns of drought were identified by applying a Principal Component Analysis (PCA) to the SPI and SPEI values at different time scales. The results revealed three heterogeneous and spatially well-defined regions with different temporal evolution of droughts: 1) Northeastern (inland desert); 2) Southern (mountainous landscape); 3) Northwestern (Mediterranean coast). The evolutionary characteristics of drought during 1961-2012 were analysed including spatial and temporal variability of SPI and SPEI, the frequency distribution, and the drought duration. The results of the non-parametric Mann-Kendall test applied to the SPI and SPEI series indicate prevailing significant negative trends (drought) at all stations. Both drought indices have been correlated both on spatial and temporal scales and they are highly comparable, especially, over a 12 and 24 month accumulation period. We concluded that the temporal and spatial characteristics of the SPI and SPEI can be used for developing a drought intensity - areal extent - and frequency curve that assesses the variability of regional droughts in Syria. The analysis of both indices suggests that all three regions had a severe drought in the 1990s, which had never been observed before in the country. Furthermore, the 2007-2010 drought was the driest period in the instrumental record, happening just before the onset of the recent conflict in Syria.

  8. Projected climatic changes on drought conditions over Spain

    Science.gov (United States)

    García-Valdecasas Ojeda, Matilde; Quishpe-Vásquez, César; Raquel Gámiz-Fortis, Sonia; Castro-Díez, Yolanda; Jesús Esteban-Parra, María

    2017-04-01

    In a context of global warming, the evapotranspiration processes will have a strong influence on drought severity. For this reason, the Standardized Precipitation Evapotranspiration Index (SPEI) was computed at different timescales in order to explore the projected drought changes for the main watersheds in Spain. For that, the Weather Research and Forecasting (WRF) model has been used in order to obtain current (1980-2010) and future (2021-2050 and 2071-2100) climate output fields. WRF model was used over a domain that spans the Iberian Peninsula with a spatial resolution of 0.088°, and nested in the coarser 0.44° EURO-CORDEX domain, and driving by the global bias-corrected climate model output data from version 1 of NCAR's Community Earth System Model (CESM1), using two different Representative Concentration Pathway (RCP) scenarios: RCP 4.5 and RCP 8.5. Besides, to examine the behavior of this drought index, a comparison with the Standardized Precipitation Index (SPI), which does not consider the evapotranspiration effects, was also performed. Additionally the relationship between the SPEI index and the soil moisture has also been analyzed. The results of this study suggest an increase in the severity and duration of drought, being larger when the SPEI index is used to define drought events. This fact confirms the relevance of taking into account the evapotranspiration processes to detect future drought events. The results also show a noticeable relationship between the SPEI and the simulated soil moisture content, which is more significant at higher timescales. Keywords: Drought, SPEI, SPI, Climatic change, Projections, WRF. Acknowledgements: This work has been financed by the projects P11-RNM-7941 (Junta de Andalucía-Spain) and CGL2013-48539-R (MINECO-Spain, FEDER).

  9. Estimating the responses of winter wheat yields to moisture variations in the past 35 years in Jiangsu Province of China.

    Science.gov (United States)

    Xu, Xiangying; Gao, Ping; Zhu, Xinkai; Guo, Wenshan; Ding, Jinfeng; Li, Chunyan

    2018-01-01

    Jiangsu is an important agricultural province in China. Winter wheat, as the second major grain crop in the province, is greatly affected by moisture variations. The objective of this study was to investigate whether there were significant trends in changes in the moisture conditions during wheat growing seasons over the past decades and how the wheat yields responded to different moisture levels by means of a popular drought index, the Standardized Precipitation Evapotranspiration Index (SPEI). The study started with a trend analysis and quantification of the moisture conditions with the Mann-Kendall test and Sen's Slope method, respectively. Then, correlation analysis was carried out to determine the relationship between de-trended wheat yields and multi-scalar SPEI. Finally, a multivariate panel regression model was established to reveal the quantitative yield responses to moisture variations. The results showed that the moisture conditions in Jiangsu were generally at a normal level, but this century appeared slightly drier in because of the relatively high temperatures. There was a significant correlation between short time scale SPEI values and wheat yields. Among the three critical stages of wheat development, the SPEI values in the late growth stage (April-June) had a closer linkage to the yields than in the seedling stage (October-November) and the over-wintering stage (December-February). Moreover, the yield responses displayed an asymmetric characteristic, namely, moisture excess led to higher yield losses compared to moisture deficit in this region. The maximum yield increment could be obtained under the moisture level of slight drought according to the 3-month SPEI at the late growth stage, while extreme wetting resulted in the most severe yield losses. The moisture conditions in the first 15 years of the 21st century were more favorable than in the last 20 years of the 20th century for wheat production in Jiangsu.

  10. Estimating the responses of winter wheat yields to moisture variations in the past 35 years in Jiangsu Province of China.

    Directory of Open Access Journals (Sweden)

    Xiangying Xu

    Full Text Available Jiangsu is an important agricultural province in China. Winter wheat, as the second major grain crop in the province, is greatly affected by moisture variations. The objective of this study was to investigate whether there were significant trends in changes in the moisture conditions during wheat growing seasons over the past decades and how the wheat yields responded to different moisture levels by means of a popular drought index, the Standardized Precipitation Evapotranspiration Index (SPEI. The study started with a trend analysis and quantification of the moisture conditions with the Mann-Kendall test and Sen's Slope method, respectively. Then, correlation analysis was carried out to determine the relationship between de-trended wheat yields and multi-scalar SPEI. Finally, a multivariate panel regression model was established to reveal the quantitative yield responses to moisture variations. The results showed that the moisture conditions in Jiangsu were generally at a normal level, but this century appeared slightly drier in because of the relatively high temperatures. There was a significant correlation between short time scale SPEI values and wheat yields. Among the three critical stages of wheat development, the SPEI values in the late growth stage (April-June had a closer linkage to the yields than in the seedling stage (October-November and the over-wintering stage (December-February. Moreover, the yield responses displayed an asymmetric characteristic, namely, moisture excess led to higher yield losses compared to moisture deficit in this region. The maximum yield increment could be obtained under the moisture level of slight drought according to the 3-month SPEI at the late growth stage, while extreme wetting resulted in the most severe yield losses. The moisture conditions in the first 15 years of the 21st century were more favorable than in the last 20 years of the 20th century for wheat production in Jiangsu.

  11. Spatiotemporal patterns of drought at various time scales in Shandong Province of Eastern China

    Science.gov (United States)

    Zuo, Depeng; Cai, Siyang; Xu, Zongxue; Li, Fulin; Sun, Wenchao; Yang, Xiaojing; Kan, Guangyuan; Liu, Pin

    2018-01-01

    The temporal variations and spatial patterns of drought in Shandong Province of Eastern China were investigated by calculating the standardized precipitation evapotranspiration index (SPEI) at 1-, 3-, 6-, 12-, and 24-month time scales. Monthly precipitation and air temperature time series during the period 1960-2012 were collected at 23 meteorological stations uniformly distributed over the region. The non-parametric Mann-Kendall test was used to explore the temporal trends of precipitation, air temperature, and the SPEI drought index. S-mode principal component analysis (PCA) was applied to identify the spatial patterns of drought. The results showed that an insignificant decreasing trend in annual total precipitation was detected at most stations, a significant increase of annual average air temperature occurred at all the 23 stations, and a significant decreasing trend in the SPEI was mainly detected at the coastal stations for all the time scales. The frequency of occurrence of extreme and severe drought at different time scales generally increased with decades; higher frequency and larger affected area of extreme and severe droughts occurred as the time scale increased, especially for the northwest of Shandong Province and Jiaodong peninsular. The spatial pattern of drought for SPEI-1 contains three regions: eastern Jiaodong Peninsular and northwestern and southern Shandong. As the time scale increased to 3, 6, and 12 months, the order of the three regions was transformed into another as northwestern Shandong, eastern Jiaodong Peninsular, and southern Shandong. For SPEI-24, the location identified by REOF1 was slightly shifted from northwestern Shandong to western Shandong, and REOF2 and REOF3 identified another two weak patterns in the south edge and north edge of Jiaodong Peninsular, respectively. The potential causes of drought and the impact of drought on agriculture in the study area have also been discussed. The temporal variations and spatial patterns

  12. Development and Evaluation of an Implementation Strategy for Collecting Data in a National Registry and the Use of Patient-Reported Outcome Measures in Physical Therapist Practices: Quality Improvement Study.

    Science.gov (United States)

    Meerhoff, Guus A; van Dulmen, Simone A; Maas, Marjo J M; Heijblom, Karin; Nijhuis-van der Sanden, Maria W G; Van der Wees, Philip J

    2017-08-01

    In 2013, the Royal Dutch Society for Physical Therapy launched the program "Quality in Motion." This program aims to collect data from electronic health record systems in a registry that is fed back to physical therapists, facilitating quality improvement. The purpose of this study was to describe the development of an implementation strategy for the program and to evaluate the feasibility of building a registry and implementing patient-reported outcome measures (PROMs) in physical therapist practices. A stepwise approach using mixed methods was established in 3 consecutive pilots with 355 physical therapists from 66 practices. Interim results were evaluated using quantitative data from a self-assessment questionnaire and the registry and qualitative data from 21 semistructured interviews with physical therapists. Descriptive statistics and McNemar's symmetry chi-squared test were used to summarize the feasibility of implementing PROMs. PROMs were selected for the 5 most prevalent musculoskeletal conditions in Dutch physical therapist practices. A core component of the implementation strategy was the introduction of knowledge brokers to support physical therapists in establishing the routine use of PROMs in clinical practice and to assist in executing peer assessment workshops. In February 2013, 30.3% of the physical therapist practices delivered 4.4 completed treatment episodes per physical therapist to the registry; this increased to 92.4% in November 2014, delivering 54.1 completed patient episodes per physical therapist. Pre- and posttreatment PROM use increased from 12.2% to 39.5%. It is unclear if the participating physical therapists reflect a representative sample of Dutch therapists. Building a registry and implementing PROMs in physical therapist practices are feasible. The routine use of PROMs needs to increase to ensure valid feedback of outcomes. Using knowledge brokers is promising for implementing the program via peer assessment workshops. © 2017

  13. A systematic review of generic multidimensional patient-reported outcome measures for children, part II: evaluation of psychometric performance of English-language versions in a general population.

    Science.gov (United States)

    Janssens, Astrid; Rogers, Morwenna; Thompson Coon, Jo; Allen, Karen; Green, Colin; Jenkinson, Crispin; Tennant, Alan; Logan, Stuart; Morris, Christopher

    2015-03-01

    The objectives of this systematic review were 1) to identify studies that assess the psychometric performance of the English-language version of 35 generic multidimensional patient-reported outcome measures (PROMs) for children and young people in general populations and evaluate their quality and 2) to summarize the psychometric properties of each PROM. MEDLINE, EMBASE, and PsycINFO were searched. The methodological quality of the articles was assessed using the COnsensus-based Standards for selection of health Measurement INstruments checklist. For each PROM, extracted evidence of content validity, construct validity, internal consistency, test-retest reliability, proxy reliability, responsiveness, and precision was judged against standardized reference criteria. We found no evidence for 14 PROMs. For the remaining 21 PROMs, 90 studies were identified. The methodological quality of most studies was fair. Quality was generally rated higher in more recent studies. Not reporting how missing data were handled was the most common reason for downgrading the quality. None of the 21 PROMs has had all psychometric properties evaluated; data on construct validity and internal consistency were most frequently reported. Overall, consistent positive findings for at least five psychometric properties were found for Child Health and Illness Profile, Healthy Pathways, KIDSCREEN, and Multi-dimensional Student Life Satisfaction Scale. None of the PROMs had been evaluated for responsiveness to detect change in general populations. Further well-designed studies with transparent reporting of methods and results are required. Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  14. What is the value of the routine use of patient-reported outcome measures toward improvement of patient outcomes, processes of care, and health service outcomes in cancer care? A systematic review of controlled trials.

    Science.gov (United States)

    Kotronoulas, Grigorios; Kearney, Nora; Maguire, Roma; Harrow, Alison; Di Domenico, David; Croy, Suzanne; MacGillivray, Stephen

    2014-05-10

    The systematic use of patient-reported outcome measures (PROMs) has been advocated as an effective way to standardize cancer practice. Yet, the question of whether PROMs can lead to actual improvements in the quality of patient care remains under debate. This review examined whether inclusion of PROM in routine clinical practice is associated with improvements in patient outcomes, processes of care, and health service outcomes during active anticancer treatment. A systematic review of five electronic databases (Medline, EMBASE, CINAHL [Cumulative Index to Nursing and Allied Health Literature], PsycINFO, and Psychology and Behavioral Sciences Collection [PBSC]) was conducted from database inception to May 2012 to locate randomized and nonrandomized controlled trials of patients receiving active anticancer treatment or supportive care irrespective of type of cancer. Based on prespecified eligibility criteria, we included 26 articles that reported on 24 unique controlled trials. Wide variability in the design and use of interventions delivered, outcomes evaluated, and cancer- and modality-specific context was apparent. Health service outcomes were only scarcely included as end points. Overall, the number of statistically significant findings were limited and PROMs' intervention effect sizes were predominantly small-to-moderate. The routine use of PROMs increases the frequency of discussion of patient outcomes during consultations. In some studies, PROMs are associated with improved symptom control, increased supportive care measures, and patient satisfaction. Additional effort is required to ensure patient adherence, as well as additional support to clinicians who will respond to patient concerns and issues, with clear system guidelines in place to guide their responses. More research is required to support PROM cost-benefit in terms of patient safety, clinician burden, and health services usage.

  15. Association between maternal urinary chromium and premature rupture of membranes in the Healthy Baby Cohort study in China.

    Science.gov (United States)

    Huang, Sha; Xia, Wei; Li, Yuanyuan; Zhang, Bin; Zhou, Aifen; Zheng, Tongzhang; Qian, Zhengmin; Huang, Zheng; Lu, Shi; Chen, Zhong; Wang, Youjie; Pan, Xinyun; Huo, Wenqian; Jin, Shuna; Jiang, Yangqian; Xu, Shunqing

    2017-11-01

    Chromium exposure from increasing industrial releases has become a threat for pregnant women due to the potential health effects on vulnerable embryos. Previous studies have suggested that maternal chromium exposure is associated with adverse birth outcomes, but no epidemiological research has been conducted to examine the relationship between chromium exposure and premature rupture of membranes (PROM). This study aimed at investigating the association of maternal urinary chromium exposure levels with PROM and was performed with 5408 pregnant women recruited from 2012 to 2014 in the city of Wuhan, China. Maternal urinary chromium collected before labor was adjusted with creatinine, and its association with PROM was evaluated using logistic regression. Each one unit increase in the natural logarithm transformed maternal urinary chromium concentration (μg/g creatinine), an odds ratio (OR) of 1.47 [95% confidence interval (CI): 1.36, 1.58] for PROM was observed. Compared to the lowest tertile of maternal urinary chromium, PROM was positively correlated with increased urinary levels of chromium (adjusted OR = 1.42; 95% CI: 1.09, 1.84 for the medium tertile; adjusted OR = 2.77; 95% CI: 2.18, 3.52 for the highest tertile). Additionally, the association of chromium with PROM appeared to be more significant among male infants (adjusted OR = 3.52; 95% CI: 2.51, 4.94 for the highest tertile) than female infants (adjusted OR = 2.16; 95% CI: 1.52, 3.06 for the highest tertile) (p for interaction = 0.05). Our large birth cohort showed an association between maternal urinary chromium levels and PROM, and the association may differ by infant gender. Further studies from different populations are needed to confirm the observed association. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Measuring outcomes in adult spinal deformity surgery: a systematic review to identify current strengths, weaknesses and gaps in patient-reported outcome measures.

    Science.gov (United States)

    Faraj, Sayf S A; van Hooff, Miranda L; Holewijn, Roderick M; Polly, David W; Haanstra, Tsjitske M; de Kleuver, Marinus

    2017-08-01

    Adult spinal deformity (ASD) causes severe disability, reduces overall quality of life, and results in a substantial societal burden of disease. As healthcare is becoming more value based, and to facilitate global benchmarking, it is critical to identify and standardize patient-reported outcome measures (PROMs). This study aims to identify the current strengths, weaknesses, and gaps in PROMs used for ASD. Studies were included following a systematic search in multiple bibliographic databases between 2000 and 2015. PROMs were extracted and linked to the outcome domains of WHO's International Classification of Functioning and Health (ICF) framework. Subsequently, the clinimetric quality of identified PROMs was evaluated. The literature search identified 144 papers that met the inclusion criteria, and nine frequently used PROMs were identified. These covered 29 ICF outcome domains, which could be grouped into three of the four main ICF chapters: body function (n = 7), activity and participation (n = 19), environmental factors (n = 3), and body structure (n = 0). A low quantity (n = 3) of papers was identified that studied the clinimetric quality of PROMs. The Scoliosis Research Society (SRS)-22 has the highest level of clinimetric quality for ASD. Outcome domains related to mobility and pain were well represented. We identified a gap in current outcome measures regarding neurological and pulmonary function. In addition, no outcome domains were measured in the ICF chapter body structure. These results will serve as a foundation for the process of seeking international consensus on a standard set of outcome domains, accompanied PROMs and contributing factors to be used in future clinical trials and spine registries.

  17. Exposure to Ambient Air Pollution and Premature Rupture of Membranes.

    Science.gov (United States)

    Wallace, Maeve E; Grantz, Katherine L; Liu, Danping; Zhu, Yeyi; Kim, Sung Soo; Mendola, Pauline

    2016-06-15

    Premature rupture of membranes (PROM) is a major factor that predisposes women to preterm delivery. Results from previous studies have suggested that there are associations between exposure to air pollution and preterm birth, but evidence of a relationship with PROM is sparse. Modified Community Multiscale Air Quality models were used to estimate mean exposures to particulate matter less than 10 µm or less than 2.5 µm in aerodynamic diameter, nitrogen oxides, carbon monoxide, sulfur dioxide, and ozone among 223,375 singleton deliveries in the Air Quality and Reproductive Health Study (2002-2008). We used log-linear models with generalized estimating equations to estimate adjusted relative risks and 95% confidence intervals for PROM per each interquartile-range increase in pollutants across the whole pregnancy, on the day of delivery, and 5 hours before delivery. Whole-pregnancy exposures to carbon monoxide and sulfur dioxide were associated with an increased risk of PROM (for carbon monoxide, relative risk (RR) = 1.09, 95% confidence interval (CI): 1.04, 1.14; for sulfur dioxide, RR = 1.15, 95% CI: 1.06, 1.25) but not preterm PROM. Ozone exposure increased the risk of PROM on the day of delivery (RR = 1.06, 95% CI: 1.02, 1.09) and 1 day prior (RR = 1.04, 95% CI: 1.01, 1.07). In the 5 hours preceding delivery, there were 3%-7% increases in risk associated with exposure to ozone and particulate matter less than 2.5 µm in aerodynamic diameter and inverse associations with exposure to carbon monoxide and nitrogen oxides. Acute and long-term air pollutant exposures merit further study in relation to PROM. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

  18. Electronic capture of patient-reported and clinician-reported outcome measures in an elective orthopaedic setting: a retrospective cohort analysis.

    Science.gov (United States)

    Malhotra, Karan; Buraimoh, Olatunbosun; Thornton, James; Cullen, Nicholas; Singh, Dishan; Goldberg, Andrew J

    2016-06-20

    To determine whether an entirely electronic system can be used to capture both patient-reported outcomes (electronic Patient-Reported Outcome Measures, ePROMs) as well as clinician-validated diagnostic and complexity data in an elective surgical orthopaedic outpatient setting. To examine patients' experience of this system and factors impacting their experience. Retrospective analysis of prospectively collected data. Single centre series. Outpatient clinics at an elective foot and ankle unit in the UK. All new adult patients attending elective orthopaedic outpatient clinics over a 32-month period. All patients were invited to complete ePROMs prior to attending their outpatient appointment. At their appointment, those patients who had not completed ePROMs were offered the opportunity to complete it on a tablet device with technical support. Matched diagnostic and complexity data were captured by the treating consultant during the appointment. Capture rates of patient-reported and clinician-reported data. All information and technology (IT) failures, language and disability barriers were captured. Patients were asked to rate their experience of using ePROMs. The scoring systems used included EQ-5D-5L, the Manchester-Oxford Foot Questionnaire (MOxFQ) and the Visual Analogue Scale (VAS) pain score. Out of 2534 new patients, 2176 (85.9%) completed ePROMs, of whom 1090 (50.09%) completed ePROMs at home/work prior to their appointment. 31.5% used a mobile (smartphone/tablet) device. Clinician-reported data were captured on 2491 patients (98.3%). The mean patient experience score of using Patient-Reported Outcome Measures (PROMs) was 8.55±1.85 out of 10 and 666 patients (30.61%) left comments. Of patients leaving comments, 214 (32.13%) felt ePROMs did not adequately capture their symptoms and these patients had significantly lower patient experience scores (ptechnology into a service improvement programme. Excellent capture rates of ePROMs and clinician

  19. HIP AND GLENOHUMERAL PASSIVE RANGE OF MOTION IN COLLEGIATE SOFTBALL PLAYERS

    Science.gov (United States)

    Plummer, Hillary; Brambeck, Allison

    2016-01-01

    Background and Purpose Range of motion deficits at the hip and glenohumeral joint (GHJ) may contribute to the incidence of injury in softball players. With injury in softball players on the rise, softball related studies in the literature are important. The purpose of this study was to examine hip and GHJ passive range of motion (PROM) patterns in collegiate softball players. Hypothesis It was hypothesized that the position players would exhibit significantly different PROM patterns than pitchers. Additionally, position players would exhibit significantly different side-to-side differences in PROM for both the hip and GHJ compared to pitchers. Study Design Prospective cohort study. Methods Forty-nine collegiate softball players (19.63 ± 1.15 years; 170.88 ± 8.08 cm; 72.96 ± 19.41 kg) participated. Passive hip and GHJ internal (IR) and external rotation (ER) measures were assessed. Glenohumeral PROM was measured with the participants supine with the arm abducted to 90 °. The measurements were recorded when the scapula began to move or a firm capsular end-feel was achieved. The hip was positioned in 90 ° of flexion and passively rotated until a capsular end-feel was achieved. Total PROM was calculated by taking the sum of IR and ER for both the hip and GHJ. Results No significant side-to-side PROM differences were observed in pitchers, at the GHJ or hip joint. Position players throwing side hip IR was significantly greater than the non-throwing side hip (p = 0.002). The non-throwing side hip had significantly greater ER compared to the throwing side hip (p = 0.002). When examining side-to-side differences at the GHJ, IR was significantly greater in the non-throwing shoulder (p = 0.047). No significant differences in total range of motion of the hip and GHJ were observed. Conclusion In the current study, position players displayed side-to-side differences in hip and GHJ IR PROM while no statistically significant differences were

  20. Prominin-2 expression increases protrusions, decreases caveolae and inhibits Cdc42 dependent fluid phase endocytosis

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Raman Deep, E-mail: Takhter.Ramandeep@mayo.edu; Schroeder, Andreas S.; Scheffer, Luana; Holicky, Eileen L.; Wheatley, Christine L.; Marks, David L., E-mail: Marks.david@mayo.edu; Pagano, Richard E.

    2013-05-10

    Highlights: •Prominin-2 expression induced protrusions that co-localized with lipid raft markers. •Prominin-2 expression decreased caveolae, caveolar endocytosis and increased pCav1. •Prominin-2 expression inhibited fluid phase endocytosis by inactivation of Cdc42. •These endocytic effects can be reversed by adding exogenous cholesterol. •Caveolin1 knockdown restored fluid phase endocytosis in Prominin2 expressing cells. -- Abstract: Background: Membrane protrusions play important roles in biological processes such as cell adhesion, wound healing, migration, and sensing of the external environment. Cell protrusions are a subtype of membrane microdomains composed of cholesterol and sphingolipids, and can be disrupted by cholesterol depletion. Prominins are pentaspan membrane proteins that bind cholesterol and localize to plasma membrane (PM) protrusions. Prominin-1 is of great interest as a marker for stem and cancer cells, while Prominin-2 (Prom2) is reportedly restricted to epithelial cells. Aim: To characterize the effects of Prom-2 expression on PM microdomain organization. Methods: Prom2-fluorescent protein was transfected in human skin fibroblasts (HSF) and Chinese hamster ovary (CHO) cells for PM raft and endocytic studies. Caveolae at PM were visualized using transmission electron microscopy. Cdc42 activation was measured and caveolin-1 knockdown was performed using siRNAs. Results: Prom2 expression in HSF and CHO cells caused extensive Prom2-positive protrusions that co-localized with lipid raft markers. Prom2 expression significantly decreased caveolae at the PM, reduced caveolar endocytosis and increased caveolin-1 phosphorylation. Prom2 expression also inhibited Cdc42-dependent fluid phase endocytosis via decreased Cdc42 activation. Effects on endocytosis were reversed by addition of cholesterol. Knockdown of caveolin-1 by siRNA restored Cdc42 dependent fluid phase endocytosis in Prom2-expressing cells. Conclusions: Prom2 protrusions primarily

  1. CD133 expression in chemo-resistant Ewing sarcoma cells

    Directory of Open Access Journals (Sweden)

    Kovar Heinrich

    2010-03-01

    Full Text Available Abstract Background Some human cancers demonstrate cellular hierarchies in which tumor-initiating cancer stem cells generate progeny cells with reduced tumorigenic potential. This cancer stem cell population is proposed to be a source of therapy-resistant and recurrent disease. Ewing sarcoma family tumors (ESFT are highly aggressive cancers in which drug-resistant, relapsed disease remains a significant clinical problem. Recently, the cell surface protein CD133 was identified as a putative marker of tumor-initiating cells in ESFT. We evaluated ESFT tumors and cell lines to determine if high levels of CD133 are associated with drug resistance. Methods Expression of the CD133-encoding PROM1 gene was determined by RT-PCR in ESFT tumors and cell lines. CD133 protein expression was assessed by western blot, FACS and/or immunostaining. Cell lines were FACS-sorted into CD133+ and CD133- fractions and proliferation, colony formation in soft agar, and in vivo tumorigenicity compared. Chemosensitivity was measured using MTS (3-(4,5-dimethylthiazol-2-yl-5-(3-carboxy-methoxyphenyl-2-(4-sulfophenyl-2H-tetrazolium assays. Results PROM1 expression was either absent or extremely low in most tumors. However, PROM1 was highly over-expressed in 4 of 48 cases. Two of the 4 patients with PROM1 over-expressing tumors rapidly succumbed to primary drug-resistant disease and two are long-term, event-free survivors. The expression of PROM1 in ESFT cell lines was similarly heterogeneous. The frequency of CD133+ cells ranged from 2-99% and, with one exception, no differences in the chemoresistance or tumorigenicity of CD133+ and CD133- cell fractions were detected. Importantly, however, the STA-ET-8.2 cell line was found to retain a cellular hierarchy in which relatively chemo-resistant, tumorigenic CD133+ cells gave rise to relatively chemo-sensitive, less tumorigenic, CD133- progeny. Conclusions Up to 10% of ESFT express high levels of PROM1. In some tumors and cell

  2. Genital infections and risk of premature rupture of membranes in Mulago Hospital, Uganda: a case control study.

    Science.gov (United States)

    Nakubulwa, Sarah; Kaye, Dan K; Bwanga, Freddie; Tumwesigye, Nazarius Mbona; Mirembe, Florence M

    2015-10-16

    Inflammatory mediators that weaken and cause membrane rupture are released during the course of genital infections among pregnant women. We set out to determine the association of common genital infections (Trichomonas vaginalis, syphilis, Neisseria gonorrhea, Chlamydia trachomatis, Group B Streptococcus, Bacterial vaginosis, Herpes Simplex Virus Type 2 and candidiasis) and premature rupture of membranes in Mulago hospital, Uganda. We conducted an unmatched case-control study among women who were in the third trimester of pregnancy at New Mulago hospital, Uganda. The cases had PROM and the controls had intact membranes during latent phase of labour in the labour ward. We used interviewer-administered questionnaires to collect data on socio-demographic characteristics, obstetric and medical history. Laboratory tests were conducted to identify T. vaginalis, syphilis, N. gonorrhea, C. trachomatis, Group B Streptococcus, Bacterial vaginosis, Herpes Simplex Virus Type 2 (HSV-2) and candidiasis. Logistic regression models were used to estimate the odds ratios (OR) and 95% CI of the association between genital infections and PROM. There was an association between PROM and abnormal vaginal discharge (OR = 2.02, 95% CI 1.10-3.70 and AOR = 2.30, 95% CI 1.18-4.47), presence of candidiasis (OR = 0.27, 95% CI 0.14-0.52 and AOR = 0.22, 95% CI 0.10-0.46) and T. vaginalis (OR = 2.98, 95% CI 1.18-7.56 and AOR = 4.22, 95% CI 1.51-11.80). However, there was no association between PROM and presence of C. trachomatis (OR = 2.05, 95% CI 0.37-11.49) and HSV-2 serostatus (OR = 1.15, 95% CI 0.63-2.09). Few or no patients with Bacterial vaginosis, Neisseria gonorrhoea, Group B streptococcus or syphilis were identified among the cases and controls. Co-infection of Trichomoniasis and candidiasis was not associated with PROM (AOR = 1.34, 95% CI 0.16-11.10). Co infection with T. vaginalis and C. trachomatis was associated with PROM (OR = 3.09, 95% CI 1.21-7.84 and AOR = 4.22, 95% CI 1

  3. An assessment of prospective memory retrieval in women with chronic fatigue syndrome using a virtual-reality environment: an initial study.

    Science.gov (United States)

    Attree, Elizabeth A; Dancey, Christine P; Pope, Alison L

    2009-08-01

    People with chronic fatigue syndrome (CFS) have increased rates of depression, anxiety, and illness intrusiveness; they may also suffer from cognitive problems such as retrospective memory (RM) deficits and concentration difficulties that can stem from diminished information-processing capability. We predicted that this diminished capacity may also lead to deficits in other cognitive functions, such as prospective memory (ProM). Event-, time-, and activity-based ProM was assessed in 11 women with CFS and 12 healthy women using a computer-generated virtual environment (VE). RM was assessed using a free-recall test, and subjective assessment of both ProM and RM was assessed by questionnaire. Groups were equivalent in age and measures of IQ. People with CFS performed slightly worse than healthy controls on both the event- and time-based ProM measures, although these were not statistically significant. However, the CFS group performed significantly worse than the healthy controls on both the free recall-task and on subjective assessment of both RM and ProM. Women with CFS do have some subtle decrements in memory, particularly RM. However, it is possible that the decrements found in the present sample would be greater in real life. Further studies utilizing both healthy controls and illness controls are now needed to ascertain how sensitive the VE measure is and to inform the development of tasks in the VE that place progressively increasing demands on working memory capacity.

  4. Toward Ensuring Health Equity: Readability and Cultural Equivalence of OMERACT Patient-reported Outcome Measures.

    Science.gov (United States)

    Petkovic, Jennifer; Epstein, Jonathan; Buchbinder, Rachelle; Welch, Vivian; Rader, Tamara; Lyddiatt, Anne; Clerehan, Rosemary; Christensen, Robin; Boonen, Annelies; Goel, Niti; Maxwell, Lara J; Toupin-April, Karine; De Wit, Maarten; Barton, Jennifer; Flurey, Caroline; Jull, Janet; Barnabe, Cheryl; Sreih, Antoine G; Campbell, Willemina; Pohl, Christoph; Duruöz, Mehmet Tuncay; Singh, Jasvinder A; Tugwell, Peter S; Guillemin, Francis

    2015-12-01

    The goal of the Outcome Measures in Rheumatology (OMERACT) 12 (2014) equity working group was to determine whether and how comprehensibility of patient-reported outcome measures (PROM) should be assessed, to ensure suitability for people with low literacy and differing cultures. The English, Dutch, French, and Turkish Health Assessment Questionnaires and English and French Osteoarthritis Knee and Hip Quality of Life questionnaires were evaluated by applying 3 readability formulas: Flesch Reading Ease, Flesch-Kincaid grade level, and Simple Measure of Gobbledygook; and a new tool, the Evaluative Linguistic Framework for Questionnaires, developed to assess text quality of questionnaires. We also considered a study assessing cross-cultural adaptation with/without back-translation and/or expert committee. The results of this preconference work were presented to the equity working group participants to gain their perspectives on the importance of comprehensibility and cross-cultural adaptation for PROM. Thirty-one OMERACT delegates attended the equity session. Twenty-six participants agreed that PROM should be assessed for comprehensibility and for use of suitable methods (4 abstained, 1 no). Twenty-two participants agreed that cultural equivalency of PROM should be assessed and suitable methods used (7 abstained, 2 no). Special interest group participants identified challenges with cross-cultural adaptation including resources required, and suggested patient involvement for improving translation and adaptation. Future work will include consensus exercises on what methods are required to ensure PROM are appropriate for people with low literacy and different cultures.

  5. Does acupuncture used in nulliparous women reduce time from prelabour rupture of membranes at term to active phase of labour? A randomised controlled trial.

    Science.gov (United States)

    Selmer-Olsen, Tone; Lydersen, Stian; Mørkved, Siv

    2007-01-01

    To assess if acupuncture influences the onset of labour and the need for induction after prelabour rupture of membranes (PROM) in nulliparous women. Further, to investigate a possible effect of acupuncture on the woman's wellbeing. In a randomised controlled trial (RCT), 106 nulliparous women with PROM were allocated to an acupuncture group (AG) or a control group (CG). The outcome measures were time from PROM to onset of active phase of labour, and rate of inductions if labour was absent after 2 days. The women's self-reported wellbeing was registered on a Visual Analogue Scale (VAS). There was no statistically significant difference between the 2 groups regarding time from PROM to active phase (median times in AG versus CG: 15 versus 20.5 h, p=0.34). Additionally, there was no difference between the 2 groups in the need for induction. We found no significant differences in self-reported wellbeing, but the women receiving acupuncture considered their treatment to be more positive than the controls (p=0.003). No adverse effects were reported. Acupuncture treatment used in nulliparas after PROM showed no significant effect in reducing time to active labour or in reducing rate of inductions. There was no change in wellbeing as a result of acupuncture, but it was considered positive to receive this kind of treatment while waiting for labour to begin.

  6. No difference in joint awareness after mobile- and fixed-bearing total knee arthroplasty: 3-year follow-up of a randomized controlled trial.

    Science.gov (United States)

    Schotanus, M G M; Pilot, P; Vos, R; Kort, N P

    2017-12-01

    To compare the patients ability to forget the artificial knee joint in everyday life who were randomized to be operated for mobile- or fixed-bearing total knee arthroplasty (TKA). This single-center randomized controlled trial evaluated the 3-year follow-up of the cemented mobile- and fixed-bearing TKA from the same brand in a series of 41 patients. Clinical examination was during the pre-, 6-week, 6-month, 1-, 2- and 3-year follow-up containing multiple patient-reported outcome measures (PROMs) including the 12-item Forgotten Joint Score (FJS-12) at 3 years. Effect size was calculated for each PROM at 3-year follow-up to quantify the size of the difference between both bearings. At 3-year follow-up, general linear mixed model analysis showed that there were no significant or clinically relevant differences between the two groups for all outcome measures. Calculated effect sizes were small (awareness was slightly lower in patients operated with the MB TKA with comparable improved clinical outcome and PROMs at 3-year follow-up. Measuring joint awareness with the FJS-12 is useful and provides more stringent information at 3-year follow-up compared to other PROMs and should be the PROM of choice at each follow-up after TKA. Level I, randomized controlled trial.

  7. Acute histologic chorioamnionitis is a risk factor for adverse neonatal outcome in late preterm birth after preterm premature rupture of membranes.

    Directory of Open Access Journals (Sweden)

    Seung Mi Lee

    Full Text Available BACKGROUND: The objective of this study was to determine whether acute histologic chorioamnionitis is associated with adverse neonatal outcomes in late preterm infants who were born after preterm PROM. METHODOLOGY/PRINCIPAL FINDINGS: The relationship between the presence of acute histologic chorioamnionitis and adverse neonatal outcome was examined in patients with preterm PROM who delivered singleton preterm newborns between 34 weeks and 36 6/7 weeks of gestation. Nonparametric statistics were used for data analysis. The frequency of acute histologic chorioamnionitis was 24% in patients with preterm PROM who delivered preterm newborns between 34 weeks and 36 6/7 weeks of gestation. Newborns born to mothers with histologic chorioamnionitis had significantly higher rates of adverse neonatal outcome (74% vs 51%; p<0.005 than those without histologic chorioamnionitis. This relationship remained significant after adjustment for gestational age at preterm PROM, gestational age at delivery, and exposure to antenatal corticosteroids. CONCLUSIONS/SIGNIFICANCE: The presence of acute histologic chorioamnionitis is associated with adverse neonatal outcome in late preterm infants born to mothers with preterm PROM.

  8. A PROSPECTIVE STUDY OF FOETOMATERNAL OUTCOME OF THE PATIENT WITH PREMATURE RUPTURE OF MEMBRANES

    Directory of Open Access Journals (Sweden)

    Satyaveer Singh

    2017-12-01

    Full Text Available BACKGROUND Before onset of labour, rupture of membrane is known as Premature rupture of membrane (PROM. PROM is one of the most common complications of pregnancy that has major impact on foetal and maternal outcomes. The aim of the present study was to evaluate the foetomaternal outcome of the patient with premature rupture of membranes, in Department of Obstetrics and Gynaecology, Umaid Hospital, Dr. Sampuranand Medical College, Jodhpur, Rajasthan, India. MATERIALS AND METHODS Randomly 100 cases were studied out during six months of period from Jan. 2016 to June 2016. RESULTS Out of 100 cases it was observed that the mean age of PROM patients was 25 ± 2.59 years with higher incidence in unbooked cases of hospital. Gestational age from 24 weeks to 42 weeks of pregnancy were included in the study. The mode of delivery in 73 patients was vaginal and 27 delivered by LSCS. The implicated risk was found i.e. anaemia (22, UTI (14, lower genital tract infection (8, Cervical stitched (1, malpresentation (5, twin (2 and 48 cases were without any risk factor. CONCLUSION Evaluation of risks of PROM and timely diagnosis is essential to reduce maternal and perinatal morbidity and mortality. Women who experience PROM should be informed that they are at higher risk of a similar complication in a subsequent pregnancy and that early initiation of prenatal care in future pregnancies could reduce the risk of another preterm delivery.

  9. Photophysical and computational investigation of the intermolecular interactions of pyrene with phenothiazine and promazine

    Energy Technology Data Exchange (ETDEWEB)

    Güloğlu, Pınar; Acar, Nursel, E-mail: nursel.acar@ege.edu.tr

    2016-10-20

    Highlights: • Intermolecular interactions of pyrene with phenothiazine/promazine were investigated. • All investigated systems were optimized at ωB97XD/6-31G(d,p) level in gas phase. • The electronic transitions were determined using frontier orbitals. • Both Py–Pheno and Py–Prom are potential candidates for charge transfer systems. - Abstract: The intermolecular interactions between the pyrene (Py) (as acceptor) and phenothiazine (Pheno), promazine (Prom) (as donors) were investigated using UV/Vis absorption and fluorescence spectroscopy. Fluorescence quenching rate constants for Py–Pheno and Py–Prom systems have been calculated approximately 10{sup 10} M{sup −1} s{sup −1}, indicating diffusion controlled processes. A computational investigation has also been carried out in gas phase at ωB97XD/6-31G(d,p) level. Time-dependent density functional theory (TDDFT) was used to calculate the electronic transitions of molecules at B3LYP/6-311++G(d,p) level. Total electronic energies, complexation energies, free energy differences, excitation wavelengths, and HOMO–LUMO energy gaps are discussed in gas phase. Analyses of first excited singlet states have indicated charge transfers transitions between Py and Pheno, Prom through π–π stacking in gas phase at 433 nm and 466 nm, respectively. Due to its charge transfer character, Py–Pheno and Py–Prom systems seem to be appropriate models to investigate and design photosensitive materials.

  10. Raised Vaginal Fluid Fibronectin Level Indicates Premature Rupture of Membrane

    Directory of Open Access Journals (Sweden)

    Amrita Bhowmik

    2012-07-01

    Full Text Available Background: Premature rupture of membrane (PROM is one of the common complications of pregnancy that has major impact on fetal and neonatal outcome. It is the commonest clinical event where a normal pregnancy becomes suddenly a high-risk one for mother and fetus or neonate. Objective: The study was undertaken to investigate whether raised fibronectin level in vaginal fluid may indicate premature rupture of membrane. Materials and Methods: This cross sectional study was conducted in the department of Obstetrics and Gynecology in Sir Salimullah Medical College & Mitford Hospital, Dhaka during the period of January 2006 to December 2007. A total of 114 pregnant women with gestational age 28th week up to 40th week were included. Sixty were PROM (Group I and 54 were non-PROM (Group II subjects. Fibronectin in vaginal fluid was measured by an immunochemical reaction by nephelometer. Statistical analysis was done by SPSS version 10.0. Results: The PROM patients had significantly higher concentration of fibronectin (225.77 ± 115.18 ng/mL compared to that in non-PROM subjects (8.04 ± 16.17 ng/mL (p < 0.001. Conclusion: It can be concluded that in cases of unequivocal rupture or intactness of the membranes, the result of the fibronectin test corresponds well with the clinical situation. So fibronectin is a sensitive test for detection of amniotic fluid in the vagina.

  11. Development of a patient-reported outcome measure of recovery after abdominal surgery: a hypothesized conceptual framework.

    Science.gov (United States)

    Alam, Roshni; Figueiredo, Sabrina M; Balvardi, Saba; Nauche, Bénédicte; Landry, Tara; Lee, Lawrence; Mayo, Nancy E; Feldman, Liane S; Fiore, Julio F

    2018-05-17

    We initiated a research program to develop a novel patient-reported outcome measure (PROM) to assess postoperative recovery from the perspective of abdominal surgery patients. In light of FDA recommendations, the first stage of our program aimed to, based on previous literature and expert input, develop a hypothesized conceptual framework portraying the health domains that are potentially relevant to the process of recovery after abdominal surgery. This study was conducted in three phases: (1) systematic review to identify PROMs with measurement properties appraised in the context of recovery after abdominal surgery, (2) content analysis to categorize the health domains covered by the PROMs according to the ICF, and (3) two-round Delphi study to gain expert input regarding which of these health domains are relevant to the process of recovery. Participants were experts in perioperative care identified through two major surgical societies (35 invited). The systematic review identified 19 PROMs covering 66 ICF domains. 23 experts (66%) participated in the Delphi process. After Round 2, experts agreed that 22 health domains (8 body functions, 14 activities and participation) are potentially relevant to the process of recovery after abdominal surgery. These domains were organized into a diagram, representing our hypothesized conceptual framework. This hypothesized conceptual framework is an important first step in our research program and will be further refined based on in-depth qualitative interviews with patients. The sound methodological approach used to derive this framework may be valuable for studies aimed to develop PROMs according to FDA standards.

  12. High-risk human papillomavirus infection is associated with premature rupture of membranes.

    Science.gov (United States)

    Cho, GeumJoon; Min, Kyung-Jin; Hong, Hye-Ri; Kim, SuhngWook; Hong, Jin-Hwa; Lee, Jae-Kwan; Oh, Min-Jeong; Kim, HaiJoong

    2013-09-06

    Human papillomavirus (HPV) is known to be more prevalent in spontaneous abortions than in elective terminations of pregnancy. More recently, placental infection with HPV was shown to be associated with spontaneous preterm delivery. However, no study has evaluated the prevalence of HPV infection in pregnant Korean females and its association with adverse pregnancy outcomes. We conducted a cross-sectional study of 311 females who gave birth at Korea University Medical Center. Our sample included 45 preterm deliveries, 50 cases of premature rupture of the membranes (PROM), 21 preeclampsia cases, and 8 gestational diabetes mellitus (GDM) patients. We used the Hybrid Capture II system to detect high-risk (HR)-HPV infection at six weeks postpartum. The prevalence of HR-HPV infection was 14.1%. Women with HR-HPV infection had a higher incidence of PROM than those without HR-HPV. HR-HPV infection was associated with an increased risk of PROM (OR, 2.380; 95% CI, 1.103-5.134). The prevalence of preterm delivery, preeclampsia, or GDM was not different between the two groups. We observed a high prevalence of HR-HPV infection in pregnant women. Moreover, HR-HPV infection was associated with a risk of PROM at term. Further studies are needed to evaluate mechanisms by which HR-HPV infection induces PROM.

  13. Acute histologic chorioamnionitis is a risk factor for adverse neonatal outcome in late preterm birth after preterm premature rupture of membranes.

    Science.gov (United States)

    Lee, Seung Mi; Park, Jeong Woo; Kim, Byoung Jae; Park, Chan-Wook; Park, Joong Shin; Jun, Jong Kwan; Yoon, Bo Hyun

    2013-01-01

    The objective of this study was to determine whether acute histologic chorioamnionitis is associated with adverse neonatal outcomes in late preterm infants who were born after preterm PROM. The relationship between the presence of acute histologic chorioamnionitis and adverse neonatal outcome was examined in patients with preterm PROM who delivered singleton preterm newborns between 34 weeks and 36 6/7 weeks of gestation. Nonparametric statistics were used for data analysis. The frequency of acute histologic chorioamnionitis was 24% in patients with preterm PROM who delivered preterm newborns between 34 weeks and 36 6/7 weeks of gestation. Newborns born to mothers with histologic chorioamnionitis had significantly higher rates of adverse neonatal outcome (74% vs 51%; p<0.005) than those without histologic chorioamnionitis. This relationship remained significant after adjustment for gestational age at preterm PROM, gestational age at delivery, and exposure to antenatal corticosteroids. The presence of acute histologic chorioamnionitis is associated with adverse neonatal outcome in late preterm infants born to mothers with preterm PROM.

  14. Use of Drought Index and Crop Modelling for Drought Impacts Analysis on Maize (Zea mays L.) Yield Loss in Bandung District

    Science.gov (United States)

    Kurniasih, E.; Impron; Perdinan

    2017-03-01

    Drought impacts on crop yield loss depend on drought magnitude and duration and on plant genotype at every plant growth stages when droughts occur. This research aims to assess the difference calculation results of 2 drought index methods and to study the maize yield loss variability impacted by drought magnitude and duration during maize growth stages in Bandung district, province of West Java, Indonesia. Droughts were quantified by the Standardized Precipitation Index (SPI) and the Standardized Precipitation Evapotranspiration Index (SPEI) at 1- to 3-month lags for the January1986-December 2015 period data. Maize yield responses to droughts were simulated by AquaCrop for the January 1986-May 2016 period of growing season. The analysis showed that the SPI and SPEI methods provided similar results in quantifying drought event. Droughts during maize reproductive stages caused the highest maize yield loss.

  15. Summer drought reconstruction in northeastern Spain inferred from a tree ring latewood network since 1734

    Science.gov (United States)

    Tejedor, E.; Saz, M. A.; Esper, J.; Cuadrat, J. M.; de Luis, M.

    2017-08-01

    Drought recurrence in the Mediterranean is regarded as a fundamental factor for socioeconomic development and the resilience of natural systems in context of global change. However, knowledge of past droughts has been hampered by the absence of high-resolution proxies. We present a drought reconstruction for the northeast of the Iberian Peninsula based on a new dendrochronology network considering the Standardized Evapotranspiration Precipitation Index (SPEI). A total of 774 latewood width series from 387 trees of P. sylvestris and P. uncinata was combined in an interregional chronology. The new chronology, calibrated against gridded climate data, reveals a robust relationship with the SPEI representing drought conditions of July and August. We developed a summer drought reconstruction for the period 1734-2013 representative for the northeastern and central Iberian Peninsula. We identified 16 extremely dry and 17 extremely wet summers and four decadal scale dry and wet periods, including 2003-2013 as the driest episode of the reconstruction.

  16. Transabdominal amnioinfusion treatment of severe oligohydramnios in preterm premature rupture of membranes at less than 26 gestational weeks.

    Science.gov (United States)

    De Santis, Marco; Scavo, Maria; Noia, Giuseppe; Masini, Lucia; Piersigilli, Fiammetta; Romagnoli, Costantino; Caruso, Alessandro

    2003-01-01

    To evaluate the efficacy of transabdominal amnioinfusion on feto-neonatal and maternal morbidity and feto-neonatal mortality. We studied 71 patients with preterm premature rupture of membranes (pPROM) at amnioinfusion with saline every 7 days in case of persistent oligohydramnios. Latency period pPROM delivery, week of delivery (26.0 vs. 22.4, pamnioinfusion-treated patients, we did not note a higher rate of complications from infection during both pregnancy and puerperium. In the amnioinfusion group, fluid loss within 6 h after infusion is the main variable in predicting pulmonary hypoplasia and neonatal survival. Our data suggest that amnioinfusion seems to be a low fetal and maternal risk technique that modifies the natural history of pPROM, improving fetal intrauterine stay and survival. Copyright 2003 S. Karger AG, Basel

  17. Hand-related physical function in rheumatic hand conditions

    DEFF Research Database (Denmark)

    Klokker, Louise; Terwee, Caroline; Wæhrens, Eva Elisabet Ejlersen

    2016-01-01

    INTRODUCTION: There is no consensus about what constitutes the most appropriate patient-reported outcome measurement (PROM) instrument for measuring physical function in patients with rheumatic hand conditions. Existing instruments lack psychometric testing and vary in feasibility...... and their psychometric qualities. We aim to develop a PROM instrument to assess hand-related physical function in rheumatic hand conditions. METHODS AND ANALYSIS: We will perform a systematic search to identify existing PROMs to rheumatic hand conditions, and select items relevant for hand-related physical function...... as well as those items from the Patient Reported Outcomes Measurement Information System (PROMIS) Physical Function (PF) item bank that are relevant to patients with rheumatic hand conditions. Selection will be based on consensus among reviewers. Content validity of selected items will be established...

  18. Hand-related physical function in rheumatic hand conditions

    DEFF Research Database (Denmark)

    Klokker, Louise; Terwee, Caroline B; Wæhrens, Eva Ejlersen

    2016-01-01

    as well as those items from the Patient Reported Outcomes Measurement Information System (PROMIS) Physical Function (PF) item bank that are relevant to patients with rheumatic hand conditions. Selection will be based on consensus among reviewers. Content validity of selected items will be established......INTRODUCTION: There is no consensus about what constitutes the most appropriate patient-reported outcome measurement (PROM) instrument for measuring physical function in patients with rheumatic hand conditions. Existing instruments lack psychometric testing and vary in feasibility...... and their psychometric qualities. We aim to develop a PROM instrument to assess hand-related physical function in rheumatic hand conditions. METHODS AND ANALYSIS: We will perform a systematic search to identify existing PROMs to rheumatic hand conditions, and select items relevant for hand-related physical function...

  19. The patellofemoral pain and osteoarthritis subscale of the KOOS (KOOS-PF)

    DEFF Research Database (Denmark)

    Crossley, Kay M; Macri, Erin M; Cowan, Sallie M

    2018-01-01

    with patellofemoral pain and/or osteoarthritis and 14 health and medical clinicians. Item reduction was performed using data from patellofemoral cohorts (n=138). We used the COnsesus-based Standards for the selection of health Measurements INstruments guidelines to evaluate reliability, validity, responsiveness......BACKGROUND: Patellofemoral pain and osteoarthritis are prevalent and associated with substantial pain and functional impairments. Patient-reported outcome measures (PROMs) are recommended for research and clinical use, but no PROMs are specific for patellofemoral osteoarthritis, and existing PROMs...... for patellofemoral pain have methodological limitations. This study aimed to develop a new subscale of the Knee injury and Osteoarthritis Outcome Score for patellofemoral pain and osteoarthritis (KOOS-PF), and evaluate its measurement properties. METHODS: Items were generated using input from 50 patients...

  20. Perspectives of patients and professionals on the use of patient reported outcome measures in primary care

    DEFF Research Database (Denmark)

    Porter, Ian; Gangannagaripalli, Jaheeda; Davey, Antoinette

    2017-01-01

    /or healthcare professional’s perspectives on the clinical utility of using PROMs in clinical practice. Results: 19 studies met the inclusion criteria (4 after 2012), 11 of which were conducted in the UK, reporting on the views of professionals (8), patients (5), and both (7). The majority of studies (12...... communication it was also noted that they undermined the human element of consultations, along with professional intuition and judgement. Burden on GP time was also noted. Conclusions: Patients and professionals highlighted a number of benefits of using PROMs in clinical practice, particularly in terms......A71 Perspectives of patients and professionals on the use of patient-reported outcome measures in primary care: a systematic review of qualitative studies Background: Although the use of patient-reported outcome measures (PROMs) in healthcare settings has increased substantially over recent years...

  1. ROLE OF GENE POLYMORFISM OF PLASMINOGEN ACTIVATOR INGIBITOR TYPE I AS A RISK FACTOR FOR PREMATURE RUPTURE OF MEMBRANE AT TERM PREGNANCY

    Directory of Open Access Journals (Sweden)

    M. G. Nikolayeva

    2013-01-01

    Full Text Available The retrospective study was designed to identify association of premature rupture of the fetal membranes (PROM with carrying polymorphisms in genes encoding folate metabolism and hemostasis in 717 women. More than one hundred potential predictors were analyzed including carriage of thrombogenic genes polymorphisms and genes encoding folate metabolism: FV[Arg506Gln], F II [20210 G/A], MTHFR [Ala222Val], (PAI-I[-675 5G/4G]. Study revealed that plasminogen activator ingibitor-1 gene polymorphism increases significantly the risk of premature rupture of the fetal membranes in term pregnancy (PROM: heterozygous plasminogen activator ingibitor-1 gene polymorphism is associated with 3.6-fold (95% CI 2.4–5.4; p < 0.001, homozygous plasminogen activator ingibitor-1 gene polymorphism – with 1.7-fold (95% CI 1.1–2.6; p = 0.01 risk rise of PROM.

  2. Development and validation of a condition-specific diary to measure severity, bothersomeness and impact on daily activities for patients with acute urinary tract infection in primary care

    DEFF Research Database (Denmark)

    Holm, Anne; Cordoba, Gloria; Siersma, Volkert

    2017-01-01

    Background: Urinary tract infection (UTI) is a common condition in primary care. Patient-reported outcome measures (PROMs) are crucial in the evaluation of interventions to improve diagnosis, treatment and prognosis of UTI. The aim of this study was to identify an existing condition-specific PROM...... for polytomous items in a cohort of 451 women participating in two studies regarding UTI. Results: No existing PROM fulfilled the inclusion criteria. Content validation resulted in one domain concerning symptom severity (18 items), one concerning bothersomeness (18 items), and one concerning impact on daily...... activities (7 items). Psychometrical validation resulted in four dimensions in each of the first two domains and one dimension in the third domain. Conclusions: Domains were not unidimensional, which meant that we identified dimensions of patient-experienced UTI that differed substantially from those...

  3. Fire activity as a function of fire–weather seasonal severity and antecedent climate across spatial scales in southern Europe and Pacific western USA

    Science.gov (United States)

    Urbieta, Itziar R.; Zavala, Gonzalo; Bedia, Joaquin; Gutierrez, Jose M.; San Miguel-Ayanz, Jesus; Camia, Andrea; Keeley, Jon E.; Moreno, Jose M.

    2015-01-01

    Climate has a strong influence on fire activity, varying across time and space. We analyzed the relationships between fire–weather conditions during the main fire season and antecedent water-balance conditions and fires in two Mediterranean-type regions with contrasted management histories: five southern countries of the European Union (EUMED)(all fires); the Pacific western coast of the USA (California and Oregon, PWUSA)(national forest fires). Total number of fires (≥1 ha), number of large fires (≥100 ha) and area burned were related to mean seasonal fire weather index (FWI), number of days over the 90th percentile of the FWI, and to the standardized precipitation-evapotranspiration index (SPEI) from the preceding 3 (spring) or 8 (autumn through spring) months. Calculations were made at three spatial aggregations in each area, and models related first-difference (year-to-year change) of fires and FWI/climate variables to minimize autocorrelation. An increase in mean seasonal FWI resulted in increases in the three fire variables across spatial scales in both regions. SPEI contributed little to explain fires, with few exceptions. Negative water-balance (dry) conditions from autumn through spring (SPEI8) were generally more important than positive conditions (moist) in spring (SPEI3), both of which contributed positively to fires. The R2 of the models generally improved with increasing area of aggregation. For total number of fires and area burned, the R2 of the models tended to decrease with increasing mean seasonal FWI. Thus, fires were more susceptible to change with climate variability in areas with less amenable conditions for fires (lower FWI) than in areas with higher mean FWI values. The relationships were similar in both regions, albeit weaker in PWUSA, probably due to the wider latitudinal gradient covered in PWUSA than in EUMED. The large variance explained by some of the models indicates that large-scale seasonal forecast could help anticipating

  4. Tipping point of a conifer forest ecosystem under severe drought

    Science.gov (United States)

    Huang, Kaicheng; Yi, Chuixiang; Wu, Donghai; Zhou, Tao; Zhao, Xiang; Blanford, William J.; Wei, Suhua; Wu, Hao; Ling, Du; Li, Zheng

    2015-02-01

    Drought-induced tree mortality has recently received considerable attention. Questions have arisen over the necessary intensity and duration thresholds of droughts that are sufficient to trigger rapid forest declines. The values of such tipping points leading to forest declines due to drought are presently unknown. In this study, we have evaluated the potential relationship between the level of tree growth and concurrent drought conditions with data of the tree growth-related ring width index (RWI) of the two dominant conifer species (Pinus edulis and Pinus ponderosa) in the Southwestern United States (SWUS) and the meteorological drought-related standardized precipitation evapotranspiration index (SPEI). In this effort, we determined the binned averages of RWI and the 11 month SPEI within the month of July within each bin of 30 of RWI in the range of 0-3000. We found a significant correlation between the binned averages of RWI and SPEI at the regional-scale under dryer conditions. The tipping point of forest declines to drought is predicted by the regression model as SPEItp = -1.64 and RWItp = 0, that is, persistence of the water deficit (11 month) with intensity of -1.64 leading to negligible growth for the conifer species. When climate conditions are wetter, the correlation between the binned averages of RWI and SPEI is weaker which we believe is most likely due to soil water and atmospheric moisture levels no longer being the dominant factor limiting tree growth. We also illustrate a potential application of the derived tipping point (SPEItp = -1.64) through an examination of the 2002 extreme drought event in the SWUS conifer forest regions. Distinguished differences in remote-sensing based NDVI anomalies were found between the two regions partitioned by the derived tipping point.

  5. Development and application of a short- /long-term composited drought index in the upper Huaihe River basin, China

    Directory of Open Access Journals (Sweden)

    M. Yu

    2015-06-01

    Full Text Available Accurate and reliable drought monitoring is of primary importance for drought mitigation and reduction of social-ecological vulnerability. The aim of the paper was to propose a short-term/long-term composited drought index (CDI which could be widely used for drought monitoring and early warning in China. In the study, the upper Huaihe River basin above the Xixian gauge station, which has been hit by severe droughts frequently in recent decades, was selected as the case study site. The short-term CDI was developed by the Principle Component Analysis of the self-calibrating Palmer Drought Severity Index (sc-PDSI, the 1- and 3-month Standardized Precipitation Evapotranspiration Index (SPEI, Z Index (ZIND, the Soil Moisture Index (SMI with the long-term CDI being formulated by use of the self-calibrating Palmer Hydrology Drought Index (sc-PHDI, the 6-, 12-, 18- and 24-month SPEI, the Standardized Streamflow Index (SSI, the SMI. The sc-PDSI, the PHDI, the ZIND, the SPEI on a monthly time scale were calculated based on the monthly air temperature and precipitation, and the monthly SMI and SSI were computed based on the simulated soil moisture and runoff by the distributed Xinanjiang model. The thresholds of the short-term/long-term CDI were determined according to frequency statistics of different drought indices. Finally, the feasibility of the two CDIs was investigated against the scPDSI, the SPEI and the historical drought records. The results revealed that the short-term/long-term CDI could capture the onset, severity, persistence of drought events very well with the former being better at identifying the dynamic evolution of drought condition while the latter better at judging the changing trend of drought over a long time period.

  6. Improved predictability of droughts over southern Africa using the standardized precipitation evapotranspiration index and ENSO

    Science.gov (United States)

    Manatsa, Desmond; Mushore, Terrence; Lenouo, Andre

    2017-01-01

    The provision of timely and reliable climate information on which to base management decisions remains a critical component in drought planning for southern Africa. In this observational study, we have not only proposed a forecasting scheme which caters for timeliness and reliability but improved relevance of the climate information by using a novel drought index called the standardised precipitation evapotranspiration index (SPEI), instead of the traditional precipitation only based index, the standardised precipitation index (SPI). The SPEI which includes temperature and other climatic factors in its construction has a more robust connection to ENSO than the SPI. Consequently, the developed ENSO-SPEI prediction scheme can provide quantitative information about the spatial extent and severity of predicted drought conditions in a way that reflects more closely the level of risk in the global warming context of the sub region. However, it is established that the ENSO significant regional impact is restricted only to the period December-March, implying a revisit to the traditional ENSO-based forecast scheme which essentially divides the rainfall season into the two periods, October to December and January to March. Although the prediction of ENSO events has increased with the refinement of numerical models, this work has demonstrated that the prediction of drought impacts related to ENSO is also a reality based only on observations. A large temporal lag is observed between the development of ENSO phenomena (typically in May of the previous year) and the identification of regional SPEI defined drought conditions. It has been shown that using the Southern Africa Regional Climate Outlook Forum's (SARCOF) traditional 3-month averaged Nino 3.4 SST index (June to August) as a predictor does not have an added advantage over using only the May SST index values. In this regard, the extended lead time and improved skill demonstrated in this study could immensely benefit

  7. Changes and Relationships of Climatic and Hydrological Droughts in the Jialing River Basin, China.

    Science.gov (United States)

    Zeng, Xiaofan; Zhao, Na; Sun, Huaiwei; Ye, Lei; Zhai, Jianqing

    2015-01-01

    The comprehensive assessment of climatic and hydrological droughts in terms of their temporal and spatial evolutions is very important for water resources management and social development in the basin scale. To study the spatial and temporal changes of climatic and hydrological droughts and the relationships between them, the SPEI and SDI are adopted to assess the changes and the correlations of climatic and hydrological droughts by selecting the Jialing River basin, China as the research area. The SPEI and SDI at different time scales are assessed both at the entire Jialing River basin and at the regional levels of the three sub basins. The results show that the SPEI and SDI are very suitable for assessing the changes and relationships of climatic and hydrological droughts in large basins. Based on the assessment, for the Jialing River basin, climatic and hydrological droughts have the increasing tendency during recent several decades, and the increasing trend of climatic droughts is significant or extremely significant in the western and northern basin, while hydrological drought has a less significant increasing trend. Additionally, climatic and hydrological droughts tend to increase in the next few years. The results also show that on short time scales, climatic droughts have one or two months lag impact on hydrological droughts in the north-west area of the basin, and have one month lag impact in south-east area of the basin. The assessment of climatic and hydrological droughts based on the SPEI and SDI could be very useful for water resources management and climate change adaptation at large basin scale.

  8. Characteristics of Droughts in South Africa: A Case Study of Free State and North West Provinces

    Directory of Open Access Journals (Sweden)

    Christina M. Botai

    2016-10-01

    Full Text Available The Free State (FS and North West (NW Provinces are often hard hit by droughts with impacts on water availability, farm production and livestock holdings. The South African government declared the two Provinces drought disaster areas in the 2015/2016 hydrological year. This is a major drawback, since both the Provinces play an important role to South African economy as they are a haven to agricultural production and have major water reservoirs in South Africa. This study was undertaken to investigate the historical evolution of drought within the FS and NW Provinces over the past 30 years. The Standardized Precipitation Index (SPI and Standardized Precipitation Evapotranspiration Index (SPEI calculated based on monthly meteorological data from 14 weather/climate stations within the FS and NW Provinces were used to explore and characterize variation in drought intensity, duration, frequency and severity in FS and NW Provinces during 1985–2015. Results indicate that there exist localized positive and negative trends with spatial dependence across the selected stations. In particular, about 60% of the weather stations exhibiting a decreasing trend are located in FS Province, suggesting that FS has being experiencing increasing drought during the analyzed period compared to NW Province. Results from the analysis of drought evaluation indicators (DEIs calculated from SPEI suggest that drought severity and frequency was more pronounced in FS while the intensity of the drought was more in NW Province during 1985–2015. In addition, based on SPEI calculations, moderate drought occurrences increased during 1985–1994 and 1995–2004 periods and decreased thereafter (2005–2015 in both Provinces. Drought classification based on parameters derived from SPEI produced similar results for mild drought occurrences during the same time scales.

  9. Changes and Relationships of Climatic and Hydrological Droughts in the Jialing River Basin, China.

    Directory of Open Access Journals (Sweden)

    Xiaofan Zeng

    Full Text Available The comprehensive assessment of climatic and hydrological droughts in terms of their temporal and spatial evolutions is very important for water resources management and social development in the basin scale. To study the spatial and temporal changes of climatic and hydrological droughts and the relationships between them, the SPEI and SDI are adopted to assess the changes and the correlations of climatic and hydrological droughts by selecting the Jialing River basin, China as the research area. The SPEI and SDI at different time scales are assessed both at the entire Jialing River basin and at the regional levels of the three sub basins. The results show that the SPEI and SDI are very suitable for assessing the changes and relationships of climatic and hydrological droughts in large basins. Based on the assessment, for the Jialing River basin, climatic and hydrological droughts have the increasing tendency during recent several decades, and the increasing trend of climatic droughts is significant or extremely significant in the western and northern basin, while hydrological drought has a less significant increasing trend. Additionally, climatic and hydrological droughts tend to increase in the next few years. The results also show that on short time scales, climatic droughts have one or two months lag impact on hydrological droughts in the north-west area of the basin, and have one month lag impact in south-east area of the basin. The assessment of climatic and hydrological droughts based on the SPEI and SDI could be very useful for water resources management and climate change adaptation at large basin scale.

  10. Economics | Page 12 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The book is a bona fide crystal ball. It will be a must read for the next decade. David Bloom, Clarence James Gamble Professor of Economics and Demography and ... of Global Health and Population, Harvard School of Public Health, USA.

  11. Uued plaadid / Koit Raudsepp

    Index Scriptorium Estoniae

    Raudsepp, Koit

    1999-01-01

    Uutest plaatidest Celine Dion "Au Coeur Du Stade", A Teens "The ABBA Generation", Apollo Four Forty "Gettin" High On Your Own Supply", Richard Bona "Scens From My Life", Marc Almond "Open All Night", Enrique Iglesias "Cosas Del Amor"

  12. 15 CFR 315.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ..., part 6, schedule 6, of the Tariff Schedules of the United States (excluding an electric trolley bus and a three-wheeled vehicle) or an automotive truck tractor. (d) Bona fide motor-vehicle manufacturer...

  13. 48 CFR 809.406-4 - Period of debarment.

    Science.gov (United States)

    2010-10-01

    ... indicated after the DSPE reviews documentary evidence submitted by or on behalf of the contractor setting... evidence, reversal of a conviction, bona fide change of ownership or management, elimination of the cause...

  14. EXACT TRAVELLING WAVE SOLUTIONS TO BBM EQUATION

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Abundant new travelling wave solutions to the BBM (Benjamin-Bona-Mahoni) equation are obtained by the generalized Jacobian elliptic function method. This method can be applied to other nonlinear evolution equations.

  15. 20 CFR 655.22 - Obligations of H-2B employers.

    Science.gov (United States)

    2010-04-01

    ..., salary, or benefits), kickbacks, bribes, tributes, in kind payments, and free labor. (k) If the employer... makes a written bona fide inquiry as to whether the other employer has displaced or intends to displace...

  16. 29 CFR 553.32 - Other FLSA exemptions.

    Science.gov (United States)

    2010-07-01

    ... a bona fide executive, administrative, professional, or outside sales capacity, as these terms are... helpers, loaders, and mechanics employed by a common carrier whose activities directly affect the safety...

  17. 41 CFR 60-20.2 - Recruitment and advertisement.

    Science.gov (United States)

    2010-07-01

    ... engaged in recruiting activity must recruit employees of both sexes for all jobs unless sex is a bona fide... advertisement in columns headed “Male” or “Female” will be considered an expression of a preference, limitation...

  18. 18 CFR 366.1 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... NATURAL GAS ACT BOOKS AND RECORDS Definitions and Provisions Under PUHCA 2005, the Federal Power Act and... with the bona fide intention of effecting distribution within 12 months of the specific securities so...

  19. Dr Flavia Schlegel Assistant Director-General for Natural Sciences UNESCO

    CERN Multimedia

    Bennett, Sophia Elizabeth

    2016-01-01

    27 January 2016 - UNESCO Assistant Director-General for Natural Sciences UNESCO F. Schlegel visiting the ATLAS experimental cavern with Collaboration Deputy Spokesperson B. Heinemann. M. Bona, Relations with International Organisations, accompanies the delegation throughout.

  20. Naine, kes ei vaadanud tagasi / Ilona Martson

    Index Scriptorium Estoniae

    Martson, Ilona, 1970-

    2008-01-01

    Raamatututvuistus: Bona, Dominique. Gala : [Dalí võimukas muusa] / prantsuse keelest tõlkinud Margot Endjärv. [Tallinn] : Kunst, 2008. Venelanna Jelena Djakonova (Gala) suhetest prantsuse luuletaja Paul Eluard'iga ja hispaania maalikunstniku Salvador Daliga

  1. 20 CFR 655.736 - What are H-1B-dependent employers and willful violators?

    Science.gov (United States)

    2010-04-01

    ... Fashion Models, and Requirements for Employers Seeking To Employ Nonimmigrants on H-1b1 and E-3 Visas in... not include bona fide consultants and independent contractors. For purposes of this section, the...

  2. Signature of a Collaboration agreement between Unitar & CERN.

    CERN Multimedia

    Pierre Gildemyn

    2012-01-01

    Signature of agreement with Mr Carlos Lopes (UNITAR) and Prof Rolf Heuer (CERN). From left to right : Einar Bjorgo, Francesco Pisano, Calors Lopes, Rolf Heuer, Maurizio Bona, Frédéric Hemmer, Olivier Van Damme

  3. 27 CFR 6.101 - Merchandise.

    Science.gov (United States)

    2010-04-01

    ... member, who is also in business as a bona fide producer or vendor of other merchandise (for example..., fixtures, signs, glassware, supplies, services, and advertising specialties to retailers does not...

  4. Patient Satisfaction with Collection of Patient-Reported Outcome Measures in Routine Care.

    Science.gov (United States)

    Recinos, Pablo F; Dunphy, Cheryl J; Thompson, Nicolas; Schuschu, Jesse; Urchek, John L; Katzan, Irene L

    2017-02-01

    Systematic collection of patient-reported outcome measures (PROMs) during ambulatory clinic visits can enhance communication between patient and provider, and provide the ability to evaluate outcomes of care. Little is known about patient satisfaction of PROM data collection in routine clinical care. To evaluate patient reaction to the routine collection of PROMs in the ambulatory setting. Before all ambulatory clinic visits at our neurological institute, patients electronically complete health status questionnaires. We administered an 8-question patient satisfaction survey to a sample of patients seen across the institute after their clinical visit. Of 343 patients approached, 323 agreed to participate. The majority responded that the questionnaire system was easy to use, was an appropriate length, and benefited their care overall (strongly agree or agree = 92.3%, 87.6%, and 77.3%, respectively). Provider review of the PROMs with the patient during the clinic visit was associated with significantly higher positive responses to all questions, even those regarding logistical aspects of the collection process. There were significant age and race differences in response to perceived benefit: those in the Black/other race category had a markedly lower probability of viewing the process favorably with increasing age. Systematic collection of PROMs via an electronic questionnaire appears to be well accepted by patients. A minority of patients did not feel the questionnaire content applied to their appointment or that the system was a beneficial feature of the clinical practice. The provider can significantly improve the patient's perception of PROM collection and the patient-physician encounter by reviewing the questionnaire results with the patient.

  5. Patient-reported outcome measures for patients with cerebral aneurysms acquired via social media: data from a large nationwide sample.

    Science.gov (United States)

    Chen, Michael; Mangubat, Erwin; Ouyang, Bichun

    2016-01-01

    With greater survival rates, patient-reported outcome measures (PROMs) among survivors of ruptured cerebral aneurysm should be an increasing concern among neurointerventionalists. Prior studies were limited in scale and generalizability. Our study aims were to (1) evaluate the validity of cerebral aneurysm PROMs obtained from social media; (2) determine the persistence of PROMs over time; and (3) determine what PROMs still exist in those with no physical impairments. By engaging national brain aneurysm support groups and using an online questionnaire modeled after the generic EQ-5D instrument, we asked respondents to classify their health in five dimensions including mobility, self-care, usual activities, pain/discomfort, and anxiety/depression using a 3-point Likert scale. In 2 months we received 604 responses from 46 states in the USA. Our cohort of ruptured aneurysm respondents reported PROMs similar to previously published series. Over time, headache and anxiety improved while depression, level of exercise, and return to work remained unchanged. We found that memory worsened after 2 years. Among those without any physical impairment, rates of 20.6%, 14.9%, 12.6%, and 23% were seen for significant headaches, significant memory loss, significant depression, and sense of life being negatively affected, respectively. Despite this novel study design, we obtained results comparable to prior studies. These results suggest that many patients with ruptured cerebral aneurysms, regardless of whether they are >2 years after the event and/or free of physical impairment, struggle with a poor quality of life. The latency, scale, and low cost of this study design may accelerate future cerebral aneurysm PROM research. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  6. [Premature rupture of fetal membranes: problems and obstetric management].

    Science.gov (United States)

    Neuhaus, W; Eibach, H W; Ahr, A; Bolte, A

    1993-12-01

    The treatment of a premature rupture of the foetal membrane (prom) has up to now been a subject of controversy. Depending on the stage of gestation, the prompt birth ensuing as a result of prom, involves the risk of immaturity of the child. Conservative waiting by contrast, exposes mother and child to a potential risk of infection. The retrospective study presented, summarises the strategies for treating prom used at the Cologne University Department of Obstetrics and Gynaecology during the period from 1984 to 1989, and attempts to develop from these data proposals for the treatment of prom. With an increase in latency of over 24 hours between prom and delivery, the maternal and neonatal rate of infection also increased significantly. An effective result of a prophylaxis with antibiotics could only be shown in the reduction of incidence of infection in the mother. An effect on the neonatal rate of infection could not be seen. Inducing prepartually lung-maturity with glucocorticoides or ambroxol resulted in a significant decrease of the RDS-rate in new born children up to the 34th week of gestation. Beyond the 34th week of gestation, this effect could not be found. Whereas after completion of the 37th week of gestation, the preferred treatment used by doctors is allowing the shortest possible time of latency between prom and delivery, the expected pulmonary immaturity before the 34th week of gestation has to be treated by prolonging the pregnancy and inducing pulmonary maturity under antibiotic prophylaxis and at the same time controlling infection.(ABSTRACT TRUNCATED AT 250 WORDS)

  7. [Dutch-language patient-reported outcome measures for foot and ankle injuries; a systematic review].

    Science.gov (United States)

    Weel, Hanneke; Zwiers, Ruben; Sierevelt, Inger N; Haverkamp, Daniel; van Dijk, C Niek; Kerkhoffs, Gino M M J

    2015-01-01

    To investigate which valid and reliable patient-reported outcome measures (PROMs) are available for foot and ankle disorders in the Dutch population, and which of these is the most suitable for uniform use. Systematic review. PubMed, Embase and Google Scholar were systematically searched for relevant articles; subsequently two researchers screened first the title and the abstract, and then the full article within a selection of these articles. Studies that described a validation process for foot- and ankle-PROMs in a Dutch population were included. Data on measurement characteristics and translation procedure were extracted, and methodological quality of the studies was assessed using the COSMIN checklist. ('COSMIN' stands for 'Consensus-based standards for the selection of health status measurement instruments'.) Two general foot- and ankle-PROMs in the Dutch language were validated: the Foot and Ankle Outcome Score (FAOS) and the Foot and Ankle Ability Measurement (FAAM); two foot-PROMs: the Manchester Foot Pain and Disability Index (MFPDI) and the 5-point Foot Function Index (FFI-5pt) were also validated. There were also two disorder-specific PROMs available in Dutch: the Victorian Institute of Sports Assessment-Achilles (VISA-A) for Achilles tendinopathies and the Foot Impact Scale for Rheumatoid Arthritis (FIS-RA) for rheumatoid arthritis patients. The FAOS and the FFI-5pt showed the strongest evidence for having good measurement characteristics. Currently, we regard the FAOS as the most appropriate foot- and ankle-PROM for general foot and ankle problems. Further studies of higher methodological quality are, however, required to draw firmer conclusions.

  8. Patient-reported outcome measures for patients with meniscal tears: a systematic review of measurement properties and evaluation with the COSMIN checklist

    Science.gov (United States)

    Middleton, Robert; Beard, David J; Price, Andrew J; Hopewell, Sally

    2017-01-01

    Objective Meniscal tears occur frequently in the population and the most common surgical treatment, arthroscopic partial meniscectomy, is performed in approximately two million cases worldwide each year. The purpose of this systematic review is to summarise and critically appraise the evidence for the use of patient-reported outcome measures (PROMs) in patients with meniscal tears. Design A systematic review was undertaken. Data on reported measurement properties were extracted and the quality of the studies appraised according to Consensus-based Standards for the Selection of Health Measurement Instruments. Data sources A search of MEDLINE, Embase, AMED and PsycINFO, unlimited by language or publication date (last search 20 February 2017). Eligibility criteria for selecting studies Development and validation studies reporting the measurement properties of PROMs in patients with meniscal tears were included. Results 11 studies and 10 PROMs were included. The overall quality of studies was poor. For measurement of symptoms and functional status, there is only very limited evidence supporting the selection of either the Lysholm Knee Scale, International Knee Documentation Committee Subjective Knee Form or the Dutch version of the Knee injury and Osteoarthritis Outcome Score. For measuring health-related quality of life, only limited evidence supports the selection of the Western Ontario Meniscal Evaluation Tool (WOMET). Of all the PROMs evaluated, WOMET has the strongest evidence for content validity. Conclusion For patients with meniscal tears, there is poor quality and incomplete evidence regarding the validity of the currently available PROMs. Further research is required to ensure these PROMs truly reflect the symptoms, function and quality of life of patients with meniscal tears. PROSPERO registration number CRD42017056847. PMID:29030413

  9. Comparison of umbilical cord interleukin-6 in preterm infants with premature rupture of membranes and intact membranes

    International Nuclear Information System (INIS)

    Gharebaghi, Manizheh M.; Peirovifar, A.; Gharebaghi, Parvin M.

    2008-01-01

    Objective was to compare inflammatory mediators in the cord blood of premature newborn infants with premature rupture of membranes (PROM) and intact membranes. Eighty-nine premature neonates with gestational age of 27-34 weeks that delivered in Ghaem Hospital in Mashhad, Iran from June 2005 to March 2006 were enrolled in a prospective observational study and their umbilical cord plasma was collected at birth. They were allocated into 2 groups (45 patients with PROM and 44 neonates with intact membranes). Interleukin-6 (IL-6) and C-reactive protein (CRP) levels were measured in cord plasma by the enzyme linked immunoassay (ELISA) method. Mean cord plasma IL-6 levels in preterm neonates with PROM was 205.71 pg/ml and in neonates with intact membranes was 33.3 pg/ml for IL-6 (p=0.000). The mean cord blood CRP level in newborns was 10.2 ug/ml, and in those with intact membranes was 1.6 ug/ml and in those with intact membranes was 1.6 ug/ml (p=0.41). Early onset sepsis was more frequent in infants with PROM than premature infants with intact membrane (38% versus 10%, p=0.001). In neonates with PROM, the mean cord blood IL-6 level was significantly higher in septic newborns (414.28 versus 40.44 pg/ml, p=0.000). The premature newborn infants with PROM had increased IL-6 levels in cord blood, which was significantly higher in neonates that developed early onset sepsis. (author)

  10. Neonatal and infant outcomes in twin gestations with preterm premature rupture of membranes at 24-31 weeks of gestation.

    Science.gov (United States)

    Mendez-Figueroa, Hector; Dahlke, Joshua D; Viteri, Oscar A; Chauhan, Suneet P; Rouse, Dwight J; Sibai, Baha M; Blackwell, Sean C

    2014-08-01

    To describe the perinatal and infant and early childhood morbidity associated with preterm premature rupture of membranes (PROM) in a cohort of twin pregnancies evaluated prospectively with neonatal follow-up to 2 years of age. This was a secondary analysis of a randomized controlled trial of magnesium sulfate for prevention of cerebral palsy. Inclusion criteria were twin gestation with preterm PROM diagnosed between 24 0/7 and 31 6/7 weeks of gestation and planned expectant management. Latency (time from membrane rupture to delivery) and perinatal outcomes were evaluated by gestational age at membrane rupture. Long-term neonatal outcomes were also analyzed. Among 151 women who met inclusion criteria, the median gestational age at preterm PROM was 28.1 weeks (range 24.1-31.6 weeks). Approximately one-third of women achieved a latency of at least 1 week. Gestational age at preterm PROM (odds ratio [OR] 0.75, 95% confidence interval [CI] 0.63-0.90 for each week after 24 weeks of gestation) and cervical dilation at admission (OR 0.66, 95% CI 0.49-0.90 for each centimeter of dilation) were inversely associated with a latency period of at least 1 week. There were no stillbirths (95% CI 0-1%), but the rate of neonatal mortality was 90 per 1,000 newborns (95% CI 57-112) with a 7.3% cerebral palsy rate among survivors (95% CI 4.4-10.3%). In twin pregnancies, preterm PROM from 24 to 31 weeks of gestation is associated with a neonatal mortality rate of 9.0% and an overall cerebral palsy rate of 7.3%. A longer latency period is associated with less advanced cervical dilation and later gestational age at PROM. LEVEL OF EVIEDENCE: II.

  11. Use of standardized precipitation evapotranspiration index to investigate drought relative to maize, in the Luvuvhu River catchment area, South Africa

    Science.gov (United States)

    Masupha, Teboho Elisa; Moeletsi, Mokhele Edmond

    2017-12-01

    Drought frequency and severity analysis during the growing period of maize was carried out by means of the Standardized Precipitation Evapotranspiration Index (SPEI) based on climatic data from seven weather stations (1975-2014). The index was aggregated at different time scales following three consecutive planting dates (October, November and December), relative to the average start of the rainy season in the area. Temporal analysis of droughts was conducted and trends were evaluated using the non-parametric Spearman's Rank Correlation test. The relative frequency distributions of the different drought categories were plotted for each growth stage of maize, with respect to the three planting dates. Results revealed an average drought occurrence of once every two seasons. The 1991/92 drought was identified as the most extreme drought during the analysis period; and generally there were no significant trends across the catchment, except for weak increasing SPEI at Levubu, Lwamondo and Thohoyandou with Spearman's ρ values of 0.4. This implies that the severity of drought decreased over time in these regions following the respective planting dates. The study further revealed that planting a 120-day maturing maize crop in December would pose a high risk of frequent severe-extreme droughts (SPEI -1.5 to ≤ -2) during the flowering to grain-filling stage at the high and moderate rainfall regions, while results at the low rainfall region indicated this risk following planting in October.

  12. Nonparametric Integrated Agrometeorological Drought Monitoring: Model Development and Application

    Science.gov (United States)

    Zhang, Qiang; Li, Qin; Singh, Vijay P.; Shi, Peijun; Huang, Qingzhong; Sun, Peng

    2018-01-01

    Drought is a major natural hazard that has massive impacts on the society. How to monitor drought is critical for its mitigation and early warning. This study proposed a modified version of the multivariate standardized drought index (MSDI) based on precipitation, evapotranspiration, and soil moisture, i.e., modified multivariate standardized drought index (MMSDI). This study also used nonparametric joint probability distribution analysis. Comparisons were done between standardized precipitation evapotranspiration index (SPEI), standardized soil moisture index (SSMI), MSDI, and MMSDI, and real-world observed drought regimes. Results indicated that MMSDI detected droughts that SPEI and/or SSMI failed to do. Also, MMSDI detected almost all droughts that were identified by SPEI and SSMI. Further, droughts detected by MMSDI were similar to real-world observed droughts in terms of drought intensity and drought-affected area. When compared to MMSDI, MSDI has the potential to overestimate drought intensity and drought-affected area across China, which should be attributed to exclusion of the evapotranspiration components from estimation of drought intensity. Therefore, MMSDI is proposed for drought monitoring that can detect agrometeorological droughts. Results of this study provide a framework for integrated drought monitoring in other regions of the world and can help to develop drought mitigation.

  13. Impacts of climate change on hydro-meteorological drought over the Volta Basin, West Africa

    Science.gov (United States)

    Oguntunde, Philip G.; Abiodun, Babatunde J.; Lischeid, Gunnar

    2017-08-01

    This study examines the characteristics of drought in the Volta River Basin (VRB), investigates the influence of drought on the streamflow, and projects the impacts of future climate change on the drought. A combination of observation data and regional climate simulations of past and future climates (1970-2013, 2046-2065, and 2081-2100) were analyzed for the study. The Standardized Precipitation Index (SPI) and Standardized Precipitation and Evapotranspiration (SPEI) were used to characterize drought while the Standardized Runoff Index (SRI) were used to quantify runoff. Results of the study show that the historical pattern of drought is generally consistent with previous studies over the Basin and most part of West Africa. RCA ensemble medians (RMED) give realistic simulations of drought characteristics and area extent over the Basin and the sub-catchments in the past climate. Generally, an increase in drought intensity and spatial extent are projected over VRB for SPEI and SPI, but the magnitude of increase is higher with SPEI than with SPI. Drought frequency (events per decade) may be magnified by a factor of 1.2 (2046-2065) to 1.6 (2081-2100) compared to the present day episodes in the basin. The coupling between streamflow and drought episodes was very strong (P planning how to minimize the negative impacts of future climate change that could have consequences on agriculture, water resources and energy supply.

  14. Future Projection of Droughts over South Korea Using Representative Concentration Pathways (RCPs

    Directory of Open Access Journals (Sweden)

    Byung Sik Kim

    2014-01-01

    Full Text Available The Standardized Precipitation Index (SPI, a method widely used to analyze droughts related to climate change, does not consider variables related to temperature and is limited because it cannot consider changes in hydrological balance, such as evapotranspiration from climate change. If we were to consider only the future increase in precipitation from climate change, droughts may decrease. However, because usable water can diminish from an increase in evapotranspiration, it is important to research on projected droughts considering the amount of evapotranspiration along with projecting and evaluating potential droughts considering the impact of climate change. As such, this study evaluated the occurrence of droughts using the Standardized Precipitation Evapotranspiration Index (SPEI as a newly conceptualized drought index that is similar to SPI but includes the temperature variability. We extracted simulated future precipitation and temperature data (2011 - 2099 from the Representative Concentration Pathway (RCP climate change scenario of IPCC AR5 to evaluate the impact of future climate change on the occurrence of droughts of South Korea. We analyzed the ratio of evapotranspiration to precipitation of meteorological observatories nationwide. In addition, we calculated the SPEI related to drought in the process to evaluate the future occurrence of droughts of South Korea. To confirm validity of SPEI results, extreme indices were analyzed. This resulted in the notion that as we go further into the future, the precipitation increases. But because of an increase in evapotranspiration also from a rise in temperature and continued dryness, the severity of droughts is projected to exacerbate.

  15. Estimation of droughts indicators in the Veguita zone, Cuba

    Science.gov (United States)

    Cumbrera, Ramiro; Millán Vega, Humberto; Tarquis, Ana Maria; Alcolea Naranjo, Osvaldo

    2016-04-01

    This work has as essential objective the evaluation and analysis of the main indicators of hydrometeorology drought in Veguita, using series of daily precipitations, daily temperature and intensity of the rain. These data were contributed by the Station Agrometeorológica of Veguitas. The estimated indexes were the concentration of precipitations (CP) and the standardized index of precipitation and evapotranspiration (SPEI). The CP was calculated by means of the calculation of the index of Gini, based on the curve of Lorentz using data from 1994 until 2013. The SPEI was calculated with the software of the same name using the data from 2001 up to 2013. The main result obtained was that the precipitations in the area are concentrating, in accordance with the index of Gini and the exponential adjustment of the curve of Lorentz. Beside it, gusts dry superiors to one month were detected and the SPEI pointed out 35 months with drought, 40 humid and 81 with normal levels of rain in the last 13 years.

  16. Conservation Laws and Traveling Wave Solutions of a Generalized Nonlinear ZK-BBM Equation

    Directory of Open Access Journals (Sweden)

    Khadijo Rashid Adem

    2014-01-01

    Full Text Available We study a generalized two-dimensional nonlinear Zakharov-Kuznetsov-Benjamin-Bona-Mahony (ZK-BBM equation, which is in fact Benjamin-Bona-Mahony equation formulated in the ZK sense. Conservation laws for this equation are constructed by using the new conservation theorem due to Ibragimov and the multiplier method. Furthermore, traveling wave solutions are obtained by employing the (G'/G-expansion method.

  17. Development and validation of an instrument to assess the prescribing readiness of medical students in Malaysia.

    Science.gov (United States)

    Lai, Pauline Siew Mei; Sim, Si Mui; Chua, Siew Siang; Tan, Choo Hock; Ng, Chirk Jenn; Achike, Francis Ifejika; Teng, Cheong Lieng

    2015-09-21

    Prescribing incompetence is an important factor that contributes to prescribing error, and this is often due to inadequate training during medical schools. We therefore aimed to develop and validate an instrument to assess the prescribing readiness of medical students (PROMS) in Malaysia. The PROMS comprised of 26 items with four domains: undergraduate learning opportunities; hands-on clinical skills practice; information gathering behaviour; and factors affecting the learning of prescribing skills. The first three domains were adapted from an existing questionnaire, while items from the last domain were formulated based on findings from a nominal group discussion. Face and content validity was determined by an expert panel, pilot tested in a class of final year (Year 5) medical students, and assessed using the Flesch reading ease. To assess the reliability of the PROMS, the internal consistency and test-retest (at baseline and 2 weeks later) were assessed using the Wilcoxon Signed Ranks test and Spearman's rho. The discriminative validity of the PROMS was assessed using the Mann-Whitney U-test (to assess if the PROMS could discriminate between final year medical students from a public and a private university). A total of 119 medical students were recruited. Flesch reading ease was 46.9, indicating that the instrument was suitable for use in participants undergoing tertiary education. The overall Cronbach alpha value of the PROMS was 0.695, which was satisfactory. Test-retest showed no difference for 25/26 items, indicating that our instrument was reliable. Responses from the public and private university final year medical students were significantly different in 10/26 items, indicating that the PROMS was able to discriminate between these two groups. Medical students from the private university reported fewer learning opportunities and hands-on practice compared to those from the public university. On the other hand, medical students from the private university

  18. Measuring Quality and Outcomes in Sports Medicine.

    Science.gov (United States)

    Ruzbarsky, Joseph J; Marom, Niv; Marx, Robert G

    2018-07-01

    Patient-reported outcome measures (PROMs) are objective metrics critical to evaluating outcomes throughout orthopedic surgery. New instruments continue to emerge, increasing the breadth of information required for those intending to use these measures for research or clinical care. Although earlier metrics were developed using the principles of classic test theory, newer instruments constructed using item response theory are amenable to computer-adaptive testing and may change the way these instruments are administered. This article aims to define the psychometric properties that are important to understand when using all PROMs and to review the most widely used instruments in sports medicine. Copyright © 2018 Elsevier Inc. All rights reserved.

  19. Five-Year Experience of Vitamin E-Diffused Highly Cross-Linked Polyethylene Wear in Total Hip Arthroplasty Assessed by Radiostereometric Analysis

    DEFF Research Database (Denmark)

    Nebergall, Audrey K; Troelsen, Anders; Rubash, Harry E

    2016-01-01

    BACKGROUND: Vitamin E-diffused highly cross-linked polyethylene (VEPE) was developed to reduce oxidation without compromising mechanical strength. The purpose of this study was to evaluate VEPE in vivo using radiostereometric analysis (RSA) and patient-reported outcome measures (PROMs). METHODS......: Fifty-one hips were enrolled. Each patient received a VEPE liner, a porous titanium shell, and an uncemented stem with a 32-mm cobalt-chrome femoral head. Tantalum beads were inserted into the VEPE to measure femoral head penetration using RSA. RSA radiographs and PROMs were obtained preoperatively...

  20. Self-patching firmware program

    International Nuclear Information System (INIS)

    Stanchi, L.

    1976-12-01

    A method of branching to an auxiliary program without any hardware or software modification at the time the auxiliary program will be written is described. Suitable statements in the main program are already prepared to accept a future program that will be written in machine language. The main program is stored as firmware in PROM memory, while the auxiliary program is loaded into RAM memory. The method is described for the Intel 8080 microprocessor, but can be generalized for any microprocessor or minicomputer that uses ROMs or PROMs. 1 figure, 2 tables

  1. Patient-Reported Outcome Measures for Use in Clinical Trials and Clinical Practice in Inflammatory Bowel Diseases: A Systematic Review.

    Science.gov (United States)

    de Jong, Marin J; Huibregtse, Roxanne; Masclee, Ad A M; Jonkers, Daisy M A E; Pierik, Marie J

    2018-05-01

    Mucosal inflammation must be carefully monitored to improve the long-term outcomes of patients with inflammatory bowel diseases (IBD). Patient-reported outcome measures (PROMs) are used increasingly to monitor disease activity in clinical practice and as endpoints in clinical trials. We performed a systematic review to provide an overview of the available PROMs on IBD activity and to evaluate their diagnostic value. A systematic search of the PubMed, Medline, Cochrane library, and Embase databases using defined keywords, identified 973 articles. These were screened by 2 independent reviewers, and 37 articles on development or validation of PROMs to assess IBD activity were identified for further analysis. Based on the recommendations of the Food and Drug Administration (FDA), the following measurement properties were evaluated: content, construct, and criterion validity; reliability; and responsiveness to change. In addition, data on ease of use in clinical practice were collected. Seventeen articles presenting 20 different PROMs were included the final analysis, although none met all the FDA-recommended criteria. Only 2 PROMs (patient-reported Harvey Bradshaw Index and Simple Clinical Colitis Activity Index scores) reported patient involvement during its development. Only 6 PROMs (patient-reported global assessment, patient assessment of disease activity, mobile health index for Crohn's disease, mobile health index for ulcerative colitis, patient-reported outcome derived from the Mayo score, and the 6-point Mayo score) were validated as markers of IBD activity, using findings from endoscopy as the reference standard; these PROMs identified patients with mucosal inflammation with area under the curve values of 0.63-0.82. The mobile health index for CD and UC scores had the best measurement properties for use in clinical practice and in clinical trials. In a systematic review, we identified more than 20 PROMS that have been developed and tested for their ability to

  2. Early Versus Delayed Passive Range of Motion After Rotator Cuff Repair: A Systematic Review and Meta-analysis.

    Science.gov (United States)

    Kluczynski, Melissa A; Nayyar, Samir; Marzo, John M; Bisson, Leslie J

    2015-08-01

    Postoperative rehabilitation has been shown to affect healing of the rotator cuff after surgical repair. However, it is unknown whether an early or delayed rehabilitation protocol is most beneficial for healing. To determine whether early versus delayed passive range of motion (PROM) affects rotator cuff (RC) retear rates after surgery. Systematic review and meta-analysis. A systematic review of the literature published between January 2003 and February 2014 was conducted. Retear rates were compared for early (within 1 week after surgery) versus delayed (3-6 weeks after surgery) PROM using χ(2) or Fisher exact tests as well as relative risks (RR) and 95% CIs. In the first analysis, data from evidence level 1 studies that directly compared early versus delayed PROM were pooled; and in the second analysis, data from level 1 to 4 studies that did not directly compare early versus delayed PROM were pooled. The second analysis was stratified by tear size and repair method. Twenty-eight studies (1729 repairs) were included. The first analysis of level 1 studies did not reveal a significant difference in retear rates for early (13.7%) versus delayed (10.5%) PROM (P = .36; RR = 1.30 [95% CI, 0.74-2.30]). The second analysis revealed that for ≤3 cm tears, the risk of retear was lower for early versus delayed PROM for transosseous (TO) plus single-row anchor (SA) repairs (18.7% vs 28.2%, P = .02; RR = 0.66 [95% CI, 0.47-0.95]). For >5 cm tears, the risk of retear was greater for early versus delayed PROM for double-row anchor (DA) repairs (56.4% vs 20%, P = .002; RR = 2.82 [95% CI, 1.31-6.07]) and for all repair methods combined (52.2% vs 22.6%, P = .01; RR = 2.31 [95% CI, 1.16-4.61]). There were no statistically significant associations for tears measuring 3 cm. Evidence is lacking with regard to the optimal timing of PROM after RC repair; however, this study suggests that tear size may be influential. © 2014 The Author(s).

  3. Do Patient-Reported Outcome Measures describe functioning in patients with low back pain, using the Brief International Classification of Functioning, Disability and Health Core Set as a reference?

    DEFF Research Database (Denmark)

    Ibsen, Charlotte; Schiøttz-Christensen, Berit; Melchiorsen, Hanne

    2016-01-01

    OBJECTIVE: To link the items in the Patient-Reported Outcome Measures (PROMs): Roland Morris Disability Questionnaire, Short Form 36 (SF-36) and pain scores, to the Brief International Classification of Functioning, Disability and Health (ICF) Core Set for low back pain, and to examine the extent...... Set (34%). A weak correlation was found between the patients' responses and the clinician's assessment. CONCLUSION: The selected PROMs do not cover the prototypical spectrum of problems encountered in patients with low back pain as defined by the Brief ICF Core Set. The clinical assessment of patients...

  4. Widespread extreme drought events in Iberia and their relationship with North Atlantic moisture flux deficit

    Science.gov (United States)

    Liberato, Margarida L. R.; Montero, Irene; Russo, Ana; Gouveia, Célia; Ramos, Alexandre M.; Trigo, Ricardo M.

    2015-04-01

    Droughts represent one of the most frequent climatic extreme events on the Iberian Peninsula, often with widespread negative ecological and environmental impacts, resulting in major socio-economic damages such as large decreases in hydroelectricity and agricultural productions or increasing forest fire risk. Unlike other weather driven extreme events, droughts duration could be from few months to several years. Here we employ a recently developed climatic drought index, the Standardized Precipitation Evapotranspiration Index (SPEI; Vicente-Serrano et al. 2010a), based on the simultaneous use of precipitation and temperature fields. This index holds the advantage of combining a multi-scalar character with the capacity to include the effects of temperature variability on drought assessment (Vicente-Serrano et al., 2010a). In this study the SPEI was computed using the Climatic Research Unit (CRU) TS3.21 High Resolution Gridded Data (0.5°) for the period 1901-2012. At this resolution the study region of Iberian Peninsula corresponds to a square of 30x30 grid pixels. The CRU Potential Evapotranspiration (PET) was used, through the Penmann-Monteith equation and the log-logistic probability distribution. This formulation allows a very good fit to the series of differences between precipitation and PET (Vicente-Serrano et al., 2010b), using monthly averages of daily maximum and minimum temperature data and also monthly precipitation records. The parameters were estimated by means of the L-moment method. The application of multi-scalar indices to the high-resolution datasets allows identifying whether the Iberian Peninsula is in hydric stress and also whether drought is installed. Based on the gridded SPEI datasets, spanning from 1901 to 2012, obtained for timescales 6, 12, 18 and 24 months, an objective method is applied for ranking the most extensive extreme drought events that occurred on the Iberian Peninsula. This objective method is based on the evaluation of the

  5. Global Warming and 21st Century Drying

    Science.gov (United States)

    Cook, Benjamin I.; Smerdun, Jason E.; Seager, Richard; Coats, Sloan

    2014-01-01

    Global warming is expected to increase the frequency and intensity of droughts in the twenty-first century, but the relative contributions from changes in moisture supply (precipitation) versus evaporative demand (potential evapotranspiration; PET) have not been comprehensively assessed. Using output from a suite of general circulation model (GCM) simulations from phase 5 of the Coupled Model Intercomparison Project, projected twentyfirst century drying and wetting trends are investigated using two offline indices of surface moisture balance: the Palmer Drought Severity Index (PDSI) and the Standardized Precipitation Evapotranspiration Index (SPEI). PDSI and SPEI projections using precipitation and Penman- Monteith based PET changes from the GCMs generally agree, showing robust cross-model drying in western North America, Central America, the Mediterranean, southern Africa, and the Amazon and robust wetting occurring in the Northern Hemisphere high latitudes and east Africa (PDSI only). The SPEI is more sensitive to PET changes than the PDSI, especially in arid regions such as the Sahara and Middle East. Regional drying and wetting patterns largely mirror the spatially heterogeneous response of precipitation in the models, although drying in the PDSI and SPEI calculations extends beyond the regions of reduced precipitation. This expansion of drying areas is attributed to globally widespread increases in PET, caused by increases in surface net radiation and the vapor pressure deficit. Increased PET not only intensifies drying in areas where precipitation is already reduced, it also drives areas into drought that would otherwise experience little drying or even wetting from precipitation trends alone. This PET amplification effect is largest in the Northern Hemisphere mid-latitudes, and is especially pronounced in western North America, Europe, and southeast China. Compared to PDSI projections using precipitation changes only, the projections incorporating both

  6. Effect of Ankle Range of Motion (ROM) and Lower-Extremity Muscle Strength on Static Balance Control Ability in Young Adults: A Regression Analysis

    Science.gov (United States)

    Kim, Seong-Gil

    2018-01-01

    Background The purpose of this study was to investigate the effect of ankle ROM and lower-extremity muscle strength on static balance control ability in young adults. Material/Methods This study was conducted with 65 young adults, but 10 young adults dropped out during the measurement, so 55 young adults (male: 19, female: 36) completed the study. Postural sway (length and velocity) was measured with eyes open and closed, and ankle ROM (AROM and PROM of dorsiflexion and plantarflexion) and lower-extremity muscle strength (flexor and extensor of hip, knee, and ankle joint) were measured. Pearson correlation coefficient was used to examine the correlation between variables and static balance ability. Simple linear regression analysis and multiple linear regression analysis were used to examine the effect of variables on static balance ability. Results In correlation analysis, plantarflexion ROM (AROM and PROM) and lower-extremity muscle strength (except hip extensor) were significantly correlated with postural sway (pregression analysis, plantar flexion PROM with eyes open significantly influenced sway length (B=0.681) and sway velocity (B=0.011). Conclusions Lower-extremity muscle strength and ankle plantarflexion ROM influenced static balance control ability, with ankle plantarflexion PROM showing the greatest influence. Therefore, both contractile structures and non-contractile structures should be of interest when considering static balance control ability improvement. PMID:29760375

  7. Antimicrobial susceptibility pattern of genital Mycoplasmas among a ...

    African Journals Online (AJOL)

    Safaa M. Abdel Rahman

    2016-02-17

    Feb 17, 2016 ... Peer review under responsibility of Alexandria University Faculty of Medicine. Alexandria Journal of ... This is an open access article under the CC BY-NC-ND license ... to pregnant women with preterm rupture of the membranes. (PROM) ... mitted pathogens M. hominis and U. urealyticum among a group of ...

  8. External cephalic version in premature rupture of membranes: a systematic review.

    Science.gov (United States)

    Quist-Nelson, Johanna; Landers, Kathryn; McCurdy, Rebekah; Berghella, Vincenzo

    2017-09-01

    External cephalic version (ECV) increases the likelihood of a vaginal delivery in patients with breech presentation. Our objective was to determine the rate of cephalic vaginal delivery in women undergoing ECV after PROM. We performed a systematic review of all case reports, case series and clinical trials of patients undergoing an ECV after PROM ≥ 24 weeks. Maternal demographics and outcome data were obtained. The primary outcome was rate of cephalic vaginal delivery. Statistical analysis was performed for continuous outcomes by calculating mean and standard deviations for appropriate variables. The systematic review yielded six papers with 13 case reports and no clinical trials of ECV after PROM. The rate of success to cephalic presentation was 46.1% (six of 13 cases), with a subsequent vaginal delivery rate of 23.1% (three of 13 cases). The rate of umbilical cord prolapse was 33.3% (two of six cases). ECV after PROM has been reported in 13 cases in the literature. For the cases reported, 46.1% of ECV were successful in turning to cephalic position, but only 23.1% resulted in a vaginal delivery. There was a 33.3% incidence of umbilical cord prolapse. Given the high rate of umbilical cord prolapse, it would be imperative to offer an ECV in the setting of PROM only at an institution that has the ability to perform the indicated emergent cesarean delivery and only after appropriate counseling.

  9. Transabdominal amnioinfusion in preterm premature rupture of membranes.

    Science.gov (United States)

    Singla, Anshuja; Yadav, Poonam; Vaid, Neelam B; Suneja, Amita; Faridi, Mohammad M A

    2010-03-01

    To evaluate the effect of transabdominal amnioinfusion on prolongation of pregnancy, and maternal and neonatal outcomes in preterm premature rupture of membranes (pPROM). We conducted a prospective randomized controlled study of women with pPROM during singleton live pregnancy-between 26 and 33+6weeks-whose amniotic fluid index (AFI) was less than the 5th percentile. The study group underwent transabdominal amnioinfusion at admission and then weekly if their AFI fell below the 5th percentile again. The control group received expectant management. The difference in the mean interval from pPROM to delivery between the groups was not statistically significant. Neonatal and maternal outcomes were significantly improved in the study group compared with the control group (fetal distress [10% vs 37%]; early neonatal sepsis [17% vs 63%]; neonatal mortality [17% vs 63%]; spontaneous delivery [83% vs 53%]; and postpartum sepsis [7% vs 33%]). Transabdominal amnioinfusion reduced fetal distress, early neonatal sepsis, and neonatal mortality. In the study group, more participants delivered spontaneously and there were fewer cases of postpartum sepsis, although the pPROM-delivery interval was not increased.

  10. Advanced public transportation systems : evaluation guidelines

    Science.gov (United States)

    1994-01-01

    The Federal Transit Administration has developed the Advanced Public Transportation Systems (APTS) Program which is an integral part of the overall U.S. DOT Intelligent Vehicle Highway Systems (IVHS) effort. A major aim of the APTS Program is to prom...

  11. Memory, microprocessor, and ASIC

    CERN Document Server

    Chen, Wai-Kai

    2003-01-01

    System Timing. ROM/PROM/EPROM. SRAM. Embedded Memory. Flash Memories. Dynamic Random Access Memory. Low-Power Memory Circuits. Timing and Signal Integrity Analysis. Microprocessor Design Verification. Microprocessor Layout Method. Architecture. ASIC Design. Logic Synthesis for Field Programmable Gate Array (EPGA) Technology. Testability Concepts and DFT. ATPG and BIST. CAD Tools for BIST/DFT and Delay Faults.

  12. Immediate combined effect of gastrocnemius stretching and sustained talocrural joint mobilization in individuals with limited ankle dorsiflexion: A randomized controlled trial.

    Science.gov (United States)

    Kang, Min-Hyeok; Oh, Jae-Seop; Kwon, Oh-Yun; Weon, Jong-Hyuk; An, Duk-Hyun; Yoo, Won-Gyu

    2015-12-01

    Although gastrocnemius stretching and talocrural joint mobilization have been suggested as effective interventions to address limited ankle dorsiflexion passive range of motion (DF PROM), the effects of a combination of the two interventions have not been identified. The aim of the present study was to compare the effects of gastrocnemius stretching combined with joint mobilization and gastrocnemius stretching alone. A randomized controlled trial. In total, 24 individuals with limited ankle DF PROM were randomized to undergo gastrocnemius stretching combined with joint mobilization (12 feet in 12 individuals) or gastrocnemius stretching alone (12 feet in 12 individuals) for 5 min. Ankle kinematics during gait (time to heel-off and ankle DF before heel-off), ankle DF PROM, posterior talar glide, and displacement of the myotendinous junction (MTJ) of the gastrocnemius were assessed before and after the interventions. The groups were compared using two-way repeated measures analysis of variance. Greater increases in the time to heel-off and ankle DF before heel-off during gait and posterior talar glide were observed in the stretching combined with joint mobilization group versus the stretching alone group. Ankle DF PROM and displacement of the MTJ of the gastrocnemius were increased significantly after the interventions in both groups, with no significant difference between them. These findings suggest that gastrocnemius stretching with joint mobilization needs to be considered to improve ankle kinematics during gait. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Simulation of a coal-fired power plant using mathematical programming algorithms in order to optimize its efficiency

    International Nuclear Information System (INIS)

    Tzolakis, G.; Papanikolaou, P.; Kolokotronis, D.; Samaras, N.; Tourlidakis, A.; Tomboulides, A.

    2012-01-01

    Since most of the world's electric energy production is mainly based on fossil fuels and need for better efficiency of the energy conversion systems is imminent, mathematical programming algorithms were applied for the simulation and optimization of a detailed model of an existing lignite-fired power plant in Kozani, Greece (KARDIA IV). The optimization of its overall thermal efficiency, using as control variables the mass flow rates of the steam turbine extractions and the fuel consumption, was performed with the use of the simulation and optimization software gPROMS. The power plant components' mathematical models were imported in software by the authors and the results showed that further increase to the overall thermal efficiency of the plant can be achieved (a 0.55% absolute increase) through reduction of the HP turbine's and increase of the LP turbine's extractions mass flow rates and the parallel reduction of the fuel consumption by 2.05% which also results to an equivalent reduction of the greenhouse gasses. The setup of the mathematical model and the flexibility of gPROMS, make this software applicable to various power plants. - Highlights: ► Modeling and simulation of the flue gases circuit of a specific plant. ► Designing of modules in gPROMS FO (Foreign Objects). ► Simulation of the complete detailed plant with gPROMS. ► Optimization using a non-linear optimization algorithm of the plant's efficiency.

  14. Effect of Ankle Range of Motion (ROM) and Lower-Extremity Muscle Strength on Static Balance Control Ability in Young Adults: A Regression Analysis.

    Science.gov (United States)

    Kim, Seong-Gil; Kim, Wan-Soo

    2018-05-15

    BACKGROUND The purpose of this study was to investigate the effect of ankle ROM and lower-extremity muscle strength on static balance control ability in young adults. MATERIAL AND METHODS This study was conducted with 65 young adults, but 10 young adults dropped out during the measurement, so 55 young adults (male: 19, female: 36) completed the study. Postural sway (length and velocity) was measured with eyes open and closed, and ankle ROM (AROM and PROM of dorsiflexion and plantarflexion) and lower-extremity muscle strength (flexor and extensor of hip, knee, and ankle joint) were measured. Pearson correlation coefficient was used to examine the correlation between variables and static balance ability. Simple linear regression analysis and multiple linear regression analysis were used to examine the effect of variables on static balance ability. RESULTS In correlation analysis, plantarflexion ROM (AROM and PROM) and lower-extremity muscle strength (except hip extensor) were significantly correlated with postural sway (psimple correlation analysis, all variables that passed the correlation analysis procedure had significant influence (plinear regression analysis, plantar flexion PROM with eyes open significantly influenced sway length (B=0.681) and sway velocity (B=0.011). CONCLUSIONS Lower-extremity muscle strength and ankle plantarflexion ROM influenced static balance control ability, with ankle plantarflexion PROM showing the greatest influence. Therefore, both contractile structures and non-contractile structures should be of interest when considering static balance control ability improvement.

  15. Development and psychometric properties of the Suicidality : Treatment Occurring in Paediatrics (STOP) Suicidality Assessment Scale (STOP-SAS) in children and adolescents

    NARCIS (Netherlands)

    Flamarique, I.; Santosh, P.; Zuddas, A.; Arango, C.; Purper-Ouakil, D.; Hoekstra, P. J.; Coghill, D.; Schulze, U.; Dittmann, R. W.; Buitelaar, J. K.; Lievesley, K.; Frongia, R.; Llorente, C.; Mendez, I.; Sala, R.; Fiori, F.; Castro-Fornieles, J.

    2016-01-01

    Background: To create a self-reported, internet-based questionnaire for the assessment of suicide risk in children and adolescents. Methods: As part of the EU project `Suicidality: Treatment Occurring in Paediatrics' (STOP project), we developed web-based Patient Reported Outcome Measures (PROMs)

  16. Development and psychometric properties of the Suicidality: Treatment Occurring in Paediatrics (STOP) Suicidality Assessment Scale (STOP-SAS) in children and adolescents

    NARCIS (Netherlands)

    Flamarique, I.; Santosh, P.; Zuddas, A.; Arango, C.; Purper-Ouakil, D.; Hoekstra, P.J.; Coghill, D.; Schulze, U.; Dittmann, R.W.; Buitelaar, J.K.; Lievesley, K.; Frongia, R.; Llorente, C.; Mendez, I.; Sala, R.; Fiori, F.; Castro-Fornieles, J.

    2016-01-01

    BACKGROUND: To create a self-reported, internet-based questionnaire for the assessment of suicide risk in children and adolescents. METHODS: As part of the EU project 'Suicidality: Treatment Occurring in Paediatrics' (STOP project), we developed web-based Patient Reported Outcome Measures (PROMs)

  17. AFRIMEDIC VOL. 1, NO. 2

    African Journals Online (AJOL)

    Buchi

    Background: Pre-labour rupture of membranes (PROM) at term is often encountered in current obstetric practice. Its management is sometimes controversial. Objectives: This was to determine the incidence, management modalities and pregnancy outcomes of cases of pre-labour rupture of membranes at term in Nnewi, ...

  18. The Iranian Military Under the Islamic Republic

    Science.gov (United States)

    1987-03-01

    usuall:, provincial, bureaucratic positions. A carefully planned program of political socialization has also been set up for the Mobilization Army. This...powerful tool for political socialization within the Basij. Those who sacrifice their lives for the revolution are prom- ised eternal life in heaven and a

  19. Analysis of combined heat and mass transfer of water- Vapor in a ...

    African Journals Online (AJOL)

    In this paper, the combined heat and mass transfer of water-vapor into a cylindrical zeolite adsorber has been numerically simulated The twodimensional heat and mass transfer equations are numerically solved using gPROMS program - a general Process Modeling System {lJ program, inserting the proper initial and ...

  20. Analysis of combined heat and mass transfer of water-vapor in a ...

    African Journals Online (AJOL)

    Jn this paper, the combined heat and mass transfer of water-vapor into a cylindrical zeolite adsorber has been numerically simulated The twodimensional heat and mass transfer equations are numerically solved using gPROMS program - a general Process Modeling System [J] program, inserting the proper initial and ...

  1. Inter-provider comparison of patient-reported outcomes: developing an adjustment to account for differences in patient case mix.

    Science.gov (United States)

    Nuttall, David; Parkin, David; Devlin, Nancy

    2015-01-01

    This paper describes the development of a methodology for the case-mix adjustment of patient-reported outcome measures (PROMs) data permitting the comparison of outcomes between providers on a like-for-like basis. Statistical models that take account of provider-specific effects form the basis of the proposed case-mix adjustment methodology. Indirect standardisation provides a transparent means of case mix adjusting the PROMs data, which are updated on a monthly basis. Recently published PROMs data for patients undergoing unilateral knee replacement are used to estimate empirical models and to demonstrate the application of the proposed case-mix adjustment methodology in practice. The results are illustrative and are used to highlight a number of theoretical and empirical issues that warrant further exploration. For example, because of differences between PROMs instruments, case-mix adjustment methodologies may require instrument-specific approaches. A number of key assumptions are made in estimating the empirical models, which could be open to challenge. The covariates of post-operative health status could be expanded, and alternative econometric methods could be employed. © 2013 Crown copyright.

  2. Development, content validity, and cross-cultural adaptation of a patient-reported outcome measure for real-time symptom assessment in irritable bowel syndrome.

    Science.gov (United States)

    Vork, L; Keszthelyi, D; Mujagic, Z; Kruimel, J W; Leue, C; Pontén, I; Törnblom, H; Simrén, M; Albu-Soda, A; Aziz, Q; Corsetti, M; Holvoet, L; Tack, J; Rao, S S; van Os, J; Quetglas, E G; Drossman, D A; Masclee, A A M

    2018-03-01

    End-of-day questionnaires, which are considered the gold standard for assessing abdominal pain and other gastrointestinal (GI) symptoms in irritable bowel syndrome (IBS), are influenced by recall and ecological bias. The experience sampling method (ESM) is characterized by random and repeated assessments in the natural state and environment of a subject, and herewith overcomes these limitations. This report describes the development of a patient-reported outcome measure (PROM) based on the ESM principle, taking into account content validity and cross-cultural adaptation. Focus group interviews with IBS patients and expert meetings with international experts in the fields of neurogastroenterology & motility and pain were performed in order to select the items for the PROM. Forward-and-back translation and cognitive interviews were performed to adapt the instrument for the use in different countries and to assure on patients' understanding with the final items. Focus group interviews revealed 42 items, categorized into five domains: physical status, defecation, mood and psychological factors, context and environment, and nutrition and drug use. Experts reduced the number of items to 32 and cognitive interviewing after translation resulted in a few slight adjustments regarding linguistic issues, but not regarding content of the items. An ESM-based PROM, suitable for momentary assessment of IBS symptom patterns was developed, taking into account content validity and cross-cultural adaptation. This PROM will be implemented in a specifically designed smartphone application and further validation in a multicenter setting will follow. © 2017 John Wiley & Sons Ltd.

  3. Reference: SITE3SORPS1 [PLACE

    Lifescience Database Archive (English)

    Full Text Available SITE3SORPS1 Villain P, Clabault G, Mache R, Zhou DX S1F binding site is related to ...but different from the light-responsive GT-1 binding site and differentially represses the spinach rps1 prom

  4. Fostering EMA's transparency policy

    DEFF Research Database (Denmark)

    Banzi, Rita; Bertele', Vittorio; Demotes-Mainard, Jacques

    2014-01-01

    The European Medicines Agency has opened a window to access clinical trial data. This is an important step forward which deserves attention, support, and advice from all the stakeholders. Regulatory agencies are the most comprehensive repositories of clinical trial data on drugs and can also prom...

  5. Patient reported outcome measures in male incontinence surgery.

    Science.gov (United States)

    Tran, M G B; Yip, J; Uveili, K; Biers, S M; Thiruchelvam, N

    2014-10-01

    Patient reported outcome measures (PROMs) were used to evaluate outcomes of the artificial urinary sphincter (AUS) and the AdVance™ (American Medical Systems, Minnetonka, MN, US) male sling system (AVMS) for the symptomatic management of male stress urinary incontinence. All male patients with stress urinary incontinence referred to our specialist clinic over a two-year period completed the ICIQ-UI SF (International Consultation on Incontinence Questionnaire on Urinary Incontinence Short Form) and the ICIQ-MLUTS LF (International Consultation on Incontinence Questionnaire on Male Lower Urinary Tract Symptoms Long Form) at consultation as well as at subsequent follow-up appointments. The Wilcoxon signed-rank test for non-parametric paired data was used for pre and postoperative comparisons. The chi-squared test was used for categorical variables. Thirty-seven patients (forty surgical cases) completed a preoperative and at least one follow-up questionnaire. There was a statistically significant improvement in PROMs postoperatively, regardless of mode of surgery (p25) had greater improvement with an AUS than with the AVMS (p<0.01). This prospective study shows that completion and collection of PROMs as part of routine clinical practice is achievable and useful in the assessment of male stress incontinence surgery. PROMs are important instruments to assess effectiveness of healthcare intervention and they are useful adjuncts in surgical studies.

  6. Muusikauudiseid maailmast / Nele-Eva Steinfeld

    Index Scriptorium Estoniae

    Steinfeld, Nele-Eva

    2016-01-01

    Lühisõnumeid maailmast: James Levine lahkub METi muusikajuhi ametist. Henry Threadgill pälvis Pulitzeri auhinna. Yehudi Menuhini nimelise konkursi võitis hiinlane Ziyu He. Suurim annetus Kopenhaageni ooperiteatrile. Kaksikvõit Carl Nielseni nimelisel konkursil. Keeruline olukord Inglise Rahvusooperis. BBC Proms pöörab pilgu Ladina-Ameerika, tšello ja Shakespeare'i poole

  7. Patient Reported Outcome Measure of Spiritual Care as Delivered by Chaplains.

    Science.gov (United States)

    Snowden, Austyn; Telfer, Iain

    2017-01-01

    Chaplains are employed by health organizations around the world to support patients in recognizing and addressing their spiritual needs. There is currently no generalizable measure of the impact of these interventions and so the clinical and strategic worth of chaplaincy is difficult to articulate. This article introduces the Scottish PROM, an original five-item patient reported outcome measure constructed specifically to address this gap. It describes the validation process from its conceptual grounding in the spiritual care literature through face and content validity cycles. It shows that the Scottish PROM is internally consistent and unidimensional. Responses to the Scottish PROM show strong convergent validity with responses to the Warwick and Edinburgh Mental Well-Being Scale, a generic well-being scale often used as a proxy for spiritual well-being. In summary, the Scottish PROM is fit for purpose. It measures the outcomes of spiritual care as delivered by chaplains in this study. This novel project introduces an essential and original breakthrough; the possibility of generalizable international chaplaincy research.

  8. Is the surgical outcome for lumbar disc herniation related to the duration of symptoms?

    DEFF Research Database (Denmark)

    Støttrup, Christian; Ernst, Carsten; Clemmensen, Dorte

    included in a Single-Center Study. Data were prospectively collected in DaneSpine, the Danish National Spine Register. The patient reported outcome measures (PROM) EQ5D, SF36, ODI, VAS-leg and -back were correlated with duration of symptoms. Findings / Results: 832 patients were included in the study...

  9. Nederlandstalige patiëntgerapporteerde uitkomstmaten voor voet- en enkelaandoeningen; Een systematisch overzicht

    NARCIS (Netherlands)

    Weel, Hanneke; Zwiers, Ruben; Sierevelt, Inger N.; Haverkamp, Daniel; van Dijk, C. Niek; Kerkhoffs, Gino M. M. J.

    2015-01-01

    To investigate which valid and reliable patient-reported outcome measures (PROMs) are available for foot and ankle disorders in the Dutch population, and which of these is the most suitable for uniform use. Systematic review. PubMed, Embase and Google Scholar were systematically searched for

  10. Spaceship earth: take your classroom into space

    NARCIS (Netherlands)

    Hartevelt, S.; van den Putte, W.; Wamsteker, J.; de Vet, S.; van Loon, J.J.W.A.; Celton, E.; Savage, N.D.L.

    2012-01-01

    Schools in Europe actively participated in the educational project "Spaceship Earth", part of ESA astronaut André Kuipers’ PromISSe mission. The initiative, conceptualized by the European Space Agency (ESA) and the Netherlands Space Office (NSO) also involved a unique collaboration of a team

  11. Fetal MRI for prediction of neonatal mortality following preterm premature rupture of the fetal membranes

    International Nuclear Information System (INIS)

    Messerschmidt, Agnes; Sauer, Alexandra; Pollak, Arnold; Pataraia, Anna; Kasprian, Gregor; Weber, Michael; Prayer, Daniela; Helmer, Hanns; Brugger, Peter C.

    2011-01-01

    Lung MRI volumetrics may be valuable for fetal assessment following early preterm premature rupture of the foetal membranes (pPROM). To evaluate the predictive value of MRI lung volumetrics after pPROM. Retrospective cohort study of 40 fetuses after pPROM in a large, tertiary, perinatal referral center. Fetuses underwent MRI lung volumetrics. Estimated lung volume was expressed as percentage of expected lung volume (our own normal references). Primary outcome was neonatal mortality due to respiratory distress before discharge from hospital. Gestational age range was 16-27 weeks. Estimated-to-expected lung volume was 73% in non-survivors and 102% in survivors (P < 0.05). There were no survivors with a lung volume less than 60% of expected. By logistic regression, mortality could be predicted with a sensitivity of 80%, specificity of 86% and accuracy of 85%. Fetal MR lung volumetrics may be useful for predicting mortality due to respiratory distress in children with early gestational pPROM. (orig.)

  12. Ostja : Eesti Raudtee viigu ookeanini / Ralf Jahncke ; interv. Ingvar Bärenklau

    Index Scriptorium Estoniae

    Jahncke, Ralf

    2006-01-01

    Saksa firma Transcare juht ja asutaja Ralf Jahncke selgitab intervjuus ettevõtte rolli Vene firma Promõshlennõje Investorõ plaanis osta osalus Eesti Raudtees ning kommenteerib, kuidas võiks laheneda Baltic Rail Services'i ja valitsuse vaheline konflikt. Lisa: TransCare

  13. 76 FR 4713 - Notice of Issuance of Final Determination Concerning the Engenio 7900 Storage System

    Science.gov (United States)

    2011-01-26

    ..., 2011. A copy of the final determination is attached. Any party-at-interest, as defined in 19 CFR 177.22...-at-interest, as defined in 19 CFR 177.22(d), may seek judicial review of a final determination within... that programming altered the character of a PROM. The essence of the article, its interconnections or...

  14. A small microprocessor based CAMAC module for testing and monitoring purposes

    CERN Document Server

    Bouquet, B; Nguyen-Ngoc, Hoan

    1981-01-01

    Summary form only given, as follows. A small microcomputer, using a Motorola 6800, has been developed. Two printed-board versions have been operating since 1979 in the NA3 experiment, and about 30 other are used for test and small experiments in various laboratories. The computer consists of a 2/25 or 3/25 CAMAC unit, which can be crate controller or branch driver. In normal use, it is connected to SA400 floppy disks and a terminal. Optionally, interfaces to a cassette unit, PROM programmer and three analog outputs can be operated on the same boards. Total memory size is 11 kbytes PROM (22 kbytes with 2716 memories) and 8 kbit RAM. Software on PROM consists of an input-output monitor, with disassembling facility, editor and local assembler, a fast and easy-to-use floppy disk monitor, and an histogram package, in 7 kbytes PROM. Some macro instructions are recognised in the assembler: message printing, CAMAC functions, initialisations and are then very easily performed. (0 refs).

  15. The Prevalence Of Sexually Transmitted Infections On Teen Pregnancies And Their Association To Adverse Pregnancy Outcomes.

    Science.gov (United States)

    Rodriguez Gonzalez, Zaskia M; Leavitt, Karla; Martin, Jose; Benabe, Erika; Romaguera, Josefina; Negrón, Ivette

    2015-01-01

    Based on our population data, the teen pregnancy rate and the prevalence of sexually transmitted infections (STIs) reported during pregnancy are worrisome. STIs appear to pose a threat to pregnancy outcomes including preterm birth (PTB), neonatal low birth weight (NLBW) and premature rupture of membranes (PROM). The objective of this study is to determine the prevalence of STIs in pregnant teens and the association of this variable to adverse pregnancy outcomes. We performed a cross sectional study to assess the prevalence of STIs among pregnant teens during a 4-year period at our institution. Birth outcomes such as gestational age at delivery, PROM and NLBW were analyzed and compared with adults. In the four years of our study, teen pregnancy rate fluctuated from 21.7% in 2010 to 16.8% in 2013. The rate of STIs for adult and teen pregnancies was similar, 21% and 23%, respectively. Chlamydia was the most common STI (67.3%) for both groups. PTB was more prevalent among adults affected with STIs than teens, 13.8% and 11.5%, respectively. NLBW was similar among teens and adults with STIs. PROM complicated 9.1% of teen pregnancies with STIs, compared to 6.7% in adults. There was no significant correlation between the STIs and adverse pregnancy outcomes on teen pregnancies for our population, except for PROM. This age group is associated with a high-risk sexual behavior and poor adherence to treatment. They would benefit from efforts to prevent unintended pregnancies and infectious diseases.

  16. 60 Review Article PRETERM RUPTURE OF MEMBRANES: THE ...

    African Journals Online (AJOL)

    Preterm prelabour rupture of membranes (PPROM) is one of the major factors that have been found to ... is because of the multiple risk factors that have been associated with PROM and also the non-uniformity in ... collagen within the extracellular matrix of the chorioamniotic membrane induced by an increased expression.

  17. Diagnosis of foetal membrane ruptures: Placental alpha ...

    African Journals Online (AJOL)

    Context: Pre‑labour rupture of membranes (PROM) is a common obstetric complication which presents a diagnostic challenge, especially in equivocal ... problematic with the need to balance the risk of prematurity with that of prolonged ... array of rapid, minimally invasive tests based on biochemical markers in amniotic fluid ...

  18. Patient-reported outcome measures for chronic obstructive pulmonary disease : the exclusion of people with low literacy skills and learning disabilities

    NARCIS (Netherlands)

    Jahagirdar, D.; Kroll, T.; Ritchie, K.; Wyke, S.

    2013-01-01

    BACKGROUND: Patient-reported outcome measures (PROMs) are intended to reflect outcomes relevant to patients. They are increasingly used for healthcare quality improvement. To produce valid measures, patients should be involved in the development process but it is unclear whether this usually

  19. Morbidities, concordance, and predictors of preterm premature ...

    African Journals Online (AJOL)

    2015-12-05

    Dec 5, 2015 ... Background: Preterm premature rupture of membranes (PPROM) is a challenging complication of ... PROM (P < 0.000), latency period (P < 0.000), and birth weight (P < 0.001). ..... J Obstet Gynecol 2000;183:271‑6. 25. Mercer ...

  20. Maailmas süveneb nõudlus lehtmetallist toodete järele / Ain Alvela

    Index Scriptorium Estoniae

    Alvela, Ain, 1967-

    2007-01-01

    Ilmunud ka: Delovõje Vedomosti : Promõshlennost 2. mai lk. 13. AS Favor on oma 17 tegevusaasta vältel teostanud allhankeid, mis on kujunenud tulusaks ja perspektiivseks äriks. Vt. samas: Tooraine tuleb hajutatud kanaleid mööda; Favori neli ärisuunda

  1. The Promposal: Youth Expressions of Identity and "Love" in the Digital Age

    Science.gov (United States)

    Richardson, John M.

    2017-01-01

    The "promposal" is a growing, North American high school ritual in which one graduating senior asks another to the prom in a creative, witty, public performance that is recorded and posted online. A "YouTube" search for "promposal" yields over 49,000 hits, with videos receiving up to 8,000,000 views. What does the…

  2. Health Equity Considerations for Developing and Reporting Patient-reported Outcomes in Clinical Trials

    DEFF Research Database (Denmark)

    Petkovic, Jennifer; Barton, Jennifer L; Flurey, Caroline

    2017-01-01

    , and (6) consideration of statistical power of subgroup analyses for outcome reporting. CONCLUSION: There is a need to (1) conduct a systematic review to assess how equity and population characteristics have been considered in PROM development and whether these differences influence the ranking...

  3. The importance of patient-reported outcome measures in reconstructive urology.

    Science.gov (United States)

    Jackson, Matthew J; N'Dow, James; Pickard, Rob

    2010-11-01

    Patient-reported outcome measures (PROMs) are now recognised as the most appropriate instruments to assess the effectiveness of healthcare interventions from the patient's perspective. The purpose of this review was to identify recent publications describing the use of PROMs following reconstructive urological surgery. A wide systematic search identified only three original articles published in the last 2 years that prospectively assessed effectiveness using a patient-completed condition-specific or generic health-related quality of life (HRQoL) instrument. These publications illustrate the need to administer PROMs at a postoperative interval relevant to the anticipated recovery phase of individual procedures. They also highlight the difference in responsiveness of generic HRQoL instruments to symptomatic improvement between straightforward conditions such as pelviureteric junction obstruction and complex multidimensional conditions such as meningomyelocele. PROMs uptake and awareness is increasing in reconstructive urology but more work is required to demonstrate the effectiveness of surgical procedures for patients and healthcare funders alike. Healthcare policy-makers now rely on these measures to determine whether specific treatments are worth financing and to compare outcomes between institutions.

  4. Comparison between the Harris- and Oxford Hip Score to evaluate outcomes one-year after total hip arthroplasty

    NARCIS (Netherlands)

    Weel, Hanneke; Lindeboom, Robert; Kuipers, Sander E.; Vervest, Ton M. J. S.

    2017-01-01

    Harris Hip Score (HHS) is a surgeon administered measurement for assessing hip function before and after total hip arthroplasties (THA). Patient reported outcome measurements (PROMs) such as the Oxford Hip Score (OHS) are increasingly used. HHS was compaired to the OHS assessing whether the HHS can

  5. BPI Challenge 2012 : the transition system case

    NARCIS (Netherlands)

    Verbeek, H.M.W.; La Rosa, M.; Soffer, P.

    2013-01-01

    Using the Transition System Miner as available in ProM6, we have investigated the control-flow perspective, the data perspective, and the resource perspective of the process that underlies the event log provided for the BPI Challenge 2012.

  6. Combining Clinical Information and Patient Reported Outcome Measures in Orthopaedic Surgery and Sports Medicine

    NARCIS (Netherlands)

    Kampen, D.A. van

    2013-01-01

    In this thesis we investigated the use of clinical information and Patient Reported Outcome Measures (PROMs) for patient evaluation in orthopaedic surgery and sports medicine. In the first part, we showed that the Dutch version of the Simple Shoulder Test (SST) is a valid and reliable

  7. Fetal MRI for prediction of neonatal mortality following preterm premature rupture of the fetal membranes

    Energy Technology Data Exchange (ETDEWEB)

    Messerschmidt, Agnes; Sauer, Alexandra; Pollak, Arnold [Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Vienna (Austria); Pataraia, Anna; Kasprian, Gregor; Weber, Michael; Prayer, Daniela [Medical University of Vienna, Department of Radiology, Vienna (Austria); Helmer, Hanns [Medical University of Vienna, Department of Obstetrics and Maternal-Fetal Medicine, Vienna (Austria); Brugger, Peter C. [Medical University of Vienna, Center of Anatomy and Cell Biology, Vienna (Austria)

    2011-11-15

    Lung MRI volumetrics may be valuable for fetal assessment following early preterm premature rupture of the foetal membranes (pPROM). To evaluate the predictive value of MRI lung volumetrics after pPROM. Retrospective cohort study of 40 fetuses after pPROM in a large, tertiary, perinatal referral center. Fetuses underwent MRI lung volumetrics. Estimated lung volume was expressed as percentage of expected lung volume (our own normal references). Primary outcome was neonatal mortality due to respiratory distress before discharge from hospital. Gestational age range was 16-27 weeks. Estimated-to-expected lung volume was 73% in non-survivors and 102% in survivors (P < 0.05). There were no survivors with a lung volume less than 60% of expected. By logistic regression, mortality could be predicted with a sensitivity of 80%, specificity of 86% and accuracy of 85%. Fetal MR lung volumetrics may be useful for predicting mortality due to respiratory distress in children with early gestational pPROM. (orig.)

  8. Human brain as the model of a new computer system. II

    Energy Technology Data Exchange (ETDEWEB)

    Holtz, K; Langheld, E

    1981-12-09

    For Pt. I see IBID., Vol. 29, No. 22, P. 13 (1981). The authors describe the self-generating system of connections of a self-teaching no-program associative computer. The self-generating systems of connections are regarded as simulation models of the human brain and compared with the brain structure. The system hardware comprises microprocessor, PROM, memory, VDU, keyboard unit.

  9. Development of the Knee Numeric-Entity Evaluation Score (KNEES – ACL)

    DEFF Research Database (Denmark)

    Comins, J D; Krogsgaard, M R; Brodersen, J

    2013-01-01

    Patient-related outcome measures (PROMs) are commonly used to gauge treatment effects in patients with anterior cruciate ligament (ACL) deficiency. Valid measures of specific conditions depend on relevant item content. While item content can be derived either from clinicians (face validity) or fr...

  10. Recalcitrant vulvodynia A clinicopathological study | Sonnedecker ...

    African Journals Online (AJOL)

    Single patients had the following specific conditions: lichen planus, lichen sclerosus, mature neuroma and chronic candidiasis. The study shows that vulvodynia is a multifactorial problem for which management strategies have evolved over the course of time. Although interferon-a-2b offers much prom.ise for the treatment ...

  11. Subclinical Histologic Chorioamnionitis and Related Clinical and Laboratory Parameters in Preterm Deliveries

    Directory of Open Access Journals (Sweden)

    Hui-Chung Wu

    2009-10-01

    Conclusion: We found that HCA was significantly correlated with lower gestational age, higher CRP level of preterm infants, higher maternal WBC count, and a higher rate of prolonged PROM. Our results demonstrate a significant association between HCA with an elevated CRP level in preterm infants. These findings further confirmed the association between maternal inflammation and preterm deliveries.

  12. Current Microbial Pattern of Patients Presenting with Pre-Labour ...

    African Journals Online (AJOL)

    Current Microbial Pattern of Patients Presenting with Pre-Labour Rupture of Membranes (PROM) at Kenyatta National Hospital, Nairobi, Kenya. ... Subject: Fifty antenatal patients with premature Rapture of Membranes and 50 controls. Results: A total of 100 questionnaires and laboratory liquor microscopic culture and ...

  13. Broad host range plasmids can invade an unexpectedly diverse fraction of a soil bacterial community

    DEFF Research Database (Denmark)

    Klümper, Uli; Riber, Leise; Dechesne, Arnaud

    2014-01-01

    and Actinobacteria suggests that inter-Gram plasmid transfer of IncP-1 and IncPromA-type plasmids is a frequent phenomenon. While the plasmid receiving fractions of the community were both plasmid- and donor- dependent, we identified a core super-permissive fraction that could take up different plasmids from diverse...

  14. Journal of EAEA, Vol 16, 1999

    African Journals Online (AJOL)

    Jn this paper, the combined heat and mass transfer of water-vapor into a cylindrical zeolite adsorber has been numerically simulated The two- dimensional heat and mass transfer equations are numerically solved using gPROMS program - a general Process Modeling System [J] program, inserting the proper initial and ...

  15. The LAMOST spectroscopic survey of globular clusters in M31 and M33. I. catalog and new identifications

    International Nuclear Information System (INIS)

    Chen, Bing-Qiu; Liu, Xiao-Wei; Xiang, Mao-Sheng; Huang, Yang; Sun, Ning-Chen; Wang, Chun; Ren, Juan-Juan; Zhang, Hua-Wei; Yuan, Hai-Bo; Rebassa-Mansergas, Alberto; Huo, Zhi-Ying; Yang, Ming; Zhang, Yong; Hou, Yong-Hui; Wang, Yue-Fei

    2015-01-01

    We present a catalog of 908 objects observed with the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) in fields in the vicinity of M31 and M33, targeted as globular clusters (GCs) and candidates. The targets include known GCs and candidates selected from the literature, as well as new candidates selected from the Sloan Digital Sky Survey (SDSS). Analysis shows that 356 of them are likely GCs with various confidence levels, while the remaining ones turn out to be background galaxies and quasars, stars and H ii regions in M31 or foreground Galactic stars. The 356 likely GCs include 298 bona fide GCs and 26 candidates known in the literature. Three candidates, selected from the Revised Bologna Catalog of M31 GCs and candidates (RBC) and one possible cluster from Johnson et al., are confirmed to be bona fide clusters. We search for new GCs in the halo of the M31 among the new candidates selected from the SDSS photometry. Based on radial velocities yielded by LAMOST spectra and visual examination of the SDSS images, we find 28 objects, 5 bona fide and 23 likely GCs. Among the five bona fide GCs, three have been recently discovered independently by others, and the remaining 25 are our new identifications, including two bona fide ones. The newly identified objects fall at projected distances ranging from 13 to 265kpc from M31. Of the two newly discovered bona fide GCs, one is located near M33, probably a GC belonging to M33. The other bona fide GC falls on the Giant Stream with a projected distance of 78 kpc from M31. Of the 23 newly identified likely GCs, one has a projected distance of about 265 kpc from M31 and could be an intergalactic cluster. (paper)

  16. Development and validation of a patient-reported outcome measure for stroke patients.

    Science.gov (United States)

    Luo, Yanhong; Yang, Jie; Zhang, Yanbo

    2015-05-08

    Family support and patient satisfaction with treatment are crucial for aiding in the recovery from stroke. However, current validated stroke-specific questionnaires may not adequately capture the impact of these two variables on patients undergoing clinical trials of new drugs. Therefore, the aim of this study was to develop and evaluate a new stroke patient-reported outcome measure (Stroke-PROM) instrument for capturing more comprehensive effects of stroke on patients participating in clinical trials of new drugs. A conceptual framework and a pool of items for the preliminary Stroke-PROM were generated by consulting the relevant literature and other questionnaires created in China and other countries, and interviewing 20 patients and 4 experts to ensure that all germane parameters were included. During the first item-selection phase, classical test theory and item response theory were applied to an initial scale completed by 133 patients with stroke. During the item-revaluation phase, classical test theory and item response theory were used again, this time with 475 patients with stroke and 104 healthy participants. During the scale assessment phase, confirmatory factor analysis was applied to the final scale of the Stroke-PROM using the same study population as in the second item-selection phase. Reliability, validity, responsiveness and feasibility of the final scale were tested. The final scale of Stroke-PROM contained 46 items describing four domains (physiology, psychology, society and treatment). These four domains were subdivided into 10 subdomains. Cronbach's α coefficients for the four domains ranged from 0.861 to 0.908. Confirmatory factor analysis supported the validity of the final scale, and the model fit index satisfied the criterion. Differences in the Stroke-PROM mean scores were significant between patients with stroke and healthy participants in nine subdomains (P < 0.001), indicating that the scale showed good responsiveness. The Stroke-PROM

  17. Development of the measure of ovarian symptoms and treatment concerns: aiming for optimal measurement of patient-reported symptom benefit with chemotherapy for symptomatic ovarian cancer.

    Science.gov (United States)

    King, Madeleine T; Stockler, Martin R; Butow, Phyllis; O'Connell, Rachel; Voysey, Merryn; Oza, Amit M; Gillies, Kim; Donovan, Heidi S; Mercieca-Bebber, Rebecca; Martyn, Julie; Sjoquist, Katrin; Friedlander, Michael L

    2014-06-01

    The aim of this study was to determine the optimal patient-reported outcome measure (PROM) for assessing symptom benefit in trials of palliative chemotherapy for women with symptomatic ovarian cancer. Candidate PROMs were EORTC QLQ-C30 plus ovarian-specific QLQ-OV28, Functional Assessment of Cancer Therapy-Ovarian (FACT-O), FACT Ovarian Symptom Index (FOSI), and gynecologic cancer-specific Symptom Representation Questionnaire. Predefined optimality criteria were inclusion of all symptoms necessary for the specified purpose, recall period covering typical length of palliative chemotherapy, numerical item rating scales, and all necessary symptoms included in a single symptom index. Qualitative and quantitative methods were applied to data from stage 1 of the Gynecologic Cancer Intergroup Symptom Benefit Study to determine the set of necessary symptoms and to objectively assess candidate PROMs against the optimality criteria. Ten necessary symptoms were identified: pain, fatigue, abdominal bloating/discomfort, sleep disturbance, bowel disturbance, nausea and vomiting, shortness of breath, poor appetite, urinary symptoms, and weight changes. Although QLQ-C30 and QLQ-OV28 together cover all these symptoms, they split them into numerous scales, dissipating potential symptom-benefit signal. Conversely, FACT-O does not cover all necessary symptoms and contains many other HRQoL-related items and treatment side effects, diluting potential symptom-benefit signal when summed into scales. Item response scales and composite scoring of all candidate PROMs were suboptimal to our specific purpose. We therefore developed a new PROM, the Measure of Ovarian Symptoms and Treatment (MOST) concerns, to provide optimal measurement for the specified purpose. This article documents the development of the MOST, a new PROM designed to assess patient-reported benefits and burden as end points in clinical trials of palliative chemotherapy for women with symptomatic ovarian cancer. The validity

  18. A randomized trial of Foley Bulb for Labor Induction in Premature Rupture of Membranes in Nulliparas (FLIP).

    Science.gov (United States)

    Amorosa, Jennifer M H; Stone, Joanne; Factor, Stephanie H; Booker, Whitney; Newland, Meredith; Bianco, Angela

    2017-09-01

    In premature rupture of membranes (PROM), the risk of chorioamnionitis increases with increasing duration of membrane rupture. Decreasing the time from PROM to delivery is associated with lower rates of maternal infection. The American College of Obstetricians and Gynecologists suggests that all women with PROM who do not have a contraindication to vaginal delivery have their labor induced instead of being managed expectantly. Although the use of oxytocin for labor induction has been demonstrated to decrease the time to delivery compared with expectant management, no studies have evaluated the effectiveness of cervical ripening with a Foley bulb to additionally decrease the time to delivery. To determine whether simultaneous use of an intracervical Foley bulb and oxytocin decreases time from induction start to delivery in nulliparous patients with PROM compared with the use of oxytocin alone. A randomized trial was conducted from August 2014 to February 2016 that compared the use of concurrent Foley bulb/oxytocin vs oxytocin alone in nulliparous patients ≥34 weeks' gestational undergoing labor induction for PROM. Our primary outcome was time from induction to delivery. Secondary outcomes were mode of delivery, tachysystole, chorioamnionitis, postpartum hemorrhage, Apgar scores, and admission to the neonatal intensive care unit. A total of 128 women were randomized. Baseline characteristics were similar between groups. We found no difference in induction-to-delivery time between women induced with concurrent Foley bulb/oxytocin vs oxytocin alone (median time 13.0 hours [interquartile 10.7, 16.1] compared with 10.8 hours [interquartile range 7.8, 16.6], respectively, P = .09). There were no significant differences in mode of delivery, rates of postpartum hemorrhage, chorioamnionitis, or epidural use. Both groups had similar rates of tachysystole as well as total oxytocin dose. There were no differences in neonatal birth weight, Apgar scores, cord gases, or

  19. Outcomes important to burns patients during scar management and how they compare to the concepts captured in burn-specific patient reported outcome measures.

    Science.gov (United States)

    Jones, Laura L; Calvert, Melanie; Moiemen, Naiem; Deeks, Jonathan J; Bishop, Jonathan; Kinghorn, Philip; Mathers, Jonathan

    2017-12-01

    Pressure garment therapy (PGT) is an established treatment for the prevention and treatment of hypertrophic scarring; however, there is limited evidence for its effectiveness. Burn survivors often experience multiple issues many of which are not adequately captured in current PGT trial measures. To assess the effectiveness of PGT it is important to understand what outcomes matter to patients and to consider whether patient-reported outcome measures (PROMs) can be used to ascertain the effect of treatments on patients' health-related quality of life. This study aimed to (a) understand the priorities and perspectives of adult burns patients and the parents of burns patients who have experienced PGT via in-depth qualitative data, and (b) compare these with the concepts captured within burn-specific PROMs. We undertook 40 semi-structured interviews with adults and parents of paediatric and adolescent burns patients who had experienced PGT to explore their priorities and perspectives on scar management. Interviews were audio-recorded, transcribed and thematically analysed. The outcomes interpreted within the interview data were then mapped against the concepts captured within burn-specific PROMs currently in the literature. Eight core outcome domains were identified as important to adult patients and parents: (1) scar characteristics and appearance, (2) movement and function, (3) scar sensation, (4) psychological distress, adjustments and a sense of normality, (5) body image and confidence, (6) engagement in activities, (7) impact on relationships, and (8) treatment burden. The outcome domains presented reflect a complex holistic patient experience of scar management and treatments such as PGT. Some currently available PROMs do capture the concepts described here, although none assess psychological adjustments and attainment of a sense of normality following burn injury. The routine use of PROMs that represent patient experience and their relative contribution to trial

  20. Short fetal leukocyte telomere length and preterm prelabor rupture of the membranes.

    Directory of Open Access Journals (Sweden)

    Ramkumar Menon

    Full Text Available BACKGROUND: Rupture of the fetal membranes is a common harbinger of imminent labor and delivery. Telomere shortening is a surrogate for oxidative stress (OS and senescence. Fetal leukocyte and placental membrane DNA telomere lengths were evaluated to determine their association with preterm prelabor rupture of the membranes (pPROM or spontaneous preterm births with intact membranes (PTB, compared to term birth. METHODS: Telomere lengths were quantified in cord blood leukocytes (n = 133 from three major groups: 1 pPROM (n = 28, 2 PTB (n = 69 and 3 uncomplicated full term births (controls, n = 35, using real-time quantitative PCR. Placental membrane specimens (n = 18 were used to correlate fetal leukocyte and placental telomere lengths. Telomere length differences among the groups were analyzed by ANOVA. Pearson correlation coefficients determined relationships between leukocyte and placental membrane telomere lengths. RESULTS: In pregnancies with intact membranes, fetal leukocyte telomere length was inversely proportional to gestational age. The mean telomere length decreased as gestation progressed, with the shortest at term. pPROM had telomere lengths (9962 ± 3124 bp that were significantly shorter than gestational age-matched PTB (11546 ± 4348 bp, p = 0.04, but comparable to term births (9011 ± 2497 bp, p = 0.31. Secondary analyses revealed no effects of race (African American vs. Caucasian or intraamniotic infection on telomere length. A strong Pearson's correlation was noted between fetal leukocyte and placental membrane telomere lengths (ρ = 0.77; p<0.01. CONCLUSIONS: Fetal leukocyte telomere length is reduced in pPROM compared to PTB but is similar to term births. pPROM represents a placental membrane disease likely mediated by OS-induced senescence.

  1. Patient-reported outcomes and adult patients' disease experience in the idiopathic inflammatory myopathies. report from the OMERACT 11 Myositis Special Interest Group.

    Science.gov (United States)

    Alexanderson, Helene; Del Grande, Maria; Bingham, Clifton O; Orbai, Ana-Maria; Sarver, Catherine; Clegg-Smith, Katherine; Lundberg, Ingrid E; Song, Yeong Wook; Christopher-Stine, Lisa

    2014-03-01

    The newly formed Outcome Measures in Rheumatology (OMERACT) Myositis Special Interest Group (SIG) was established to examine patient-reported outcome measures (PROM) in myositis. At OMERACT 11, a literature review of PROM used in the idiopathic inflammatory myopathies (IIM) and other neuromuscular conditions was presented. The group examined in more detail 2 PROM more extensively evaluated in patients with IIM, the Myositis Activities Profile, and the McMaster-Toronto Arthritis Patient Preference Disability Questionnaire, through the OMERACT filter of truth, discrimination, and feasibility. Preliminary results from a qualitative study of patients with myositis regarding their symptoms were discussed that emphasized the range of symptoms experienced: pain, physical tightness/stiffness, fatigue, disease effect on emotional life and relationships, and treatment-related side effects. Following discussion of these results and following additional discussions since OMERACT 11, a research agenda was developed. The next step in evaluating PROM in IIM will require additional focus groups with a spectrum of patients with different myositis disease phenotypes and manifestations across a range of disease activity, and from multiple international settings. The group will initially focus on dermatomyositis and polymyositis in adults. Qualitative analysis will facilitate the identification of commonalities and divergent patient-relevant aspects of disease, insights that are critical given the heterogeneous manifestations of these diseases. Based on these qualitative studies, existing myositis PROM can be examined to more thoroughly assess content validity, and will be important to identify gaps in domain measurement that will be required to develop a preliminary core set of patient-relevant domains for IIM.

  2. The Examination of Patient-Reported Outcomes and Postural Control Measures in Patients With and Without a History of ACL Reconstruction: A Case Control Study.

    Science.gov (United States)

    Hoch, Johanna M; Sinnott, Cori W; Robinson, Kendall P; Perkins, William O; Hartman, Jonathan W

    2018-03-01

    There is a lack of literature to support the diagnostic accuracy and cut-off scores of commonly used patient-reported outcome measures (PROMs) and clinician-oriented outcomes such as postural-control assessments (PCAs) when treating post-ACL reconstruction (ACLR) patients. These scores could help tailor treatments, enhance patient-centered care and may identify individuals in need of additional rehabilitation. To determine if differences in 4-PROMs and 3-PCAs exist between post-ACLR and healthy participants, and to determine the diagnostic accuracy and cut-off scores of these outcomes. Case control. Laboratory. A total of 20 post-ACLR and 40 healthy control participants. The participants completed 4-PROMs (the Disablement in the Physically Active Scale [DPA], The Fear-Avoidance Belief Questionnaire [FABQ], the Knee Osteoarthritis Outcomes Score [KOOS] subscales, and the Tampa Scale of Kinesiophobia [TSK-11]) and 3-PCAs (the Balance Error Scoring System [BESS], the modified Star Excursion Balance Test [SEBT], and static balance on an instrumented force plate). Mann-Whitney U tests examined differences between groups. Receiver operating characteristic (ROC) curves were employed to determine sensitivity and specificity. The Area Under the Curve (AUC) was calculated to determine the diagnostic accuracy of each instrument. The Youdin Index was used to determine cut-off scores. Alpha was set a priori at P < 0.05. There were significant differences between groups for all PROMs (P < 0.05). There were no differences in PCAs between groups. The cut-off scores should be interpreted with caution for some instruments, as the scores may not be clinically applicable. Post-ACLR participants have decreased self-reported function and health-related quality of life. The PROMs are capable of discriminating between groups. Clinicians should consider using the cut-off scores in clinical practice. Further use of the instruments to examine detriments after completion of standard

  3. A review of preference-based measures for the assessment of quality of life in children and adolescents with cerebral palsy.

    Science.gov (United States)

    Mpundu-Kaambwa, Christine; Chen, Gang; Huynh, Elisabeth; Russo, Remo; Ratcliffe, Julie

    2018-03-22

    To examine the psychometric properties and suitability for use within the context of cerebral palsy research in children and adolescents of generic preference-based outcome measures (PROMs). Nine electronic databases were searched in this systematic review. The consensus-based standards for the selection of health measurement instruments (COSMIN) checklist were used to measure the psychometric properties of the PROMs. A meta-analysis was used to pool correlation coefficients for convergent validity using the Schmidt-Hunter method. Heterogeneity was assessed using the I-squared statistic (I 2 ). Four preference-based PROMs were identified from eight studies: Health Utilities Index-Mark 2 and 3 (HUI-2 and HUI-3, respectively), the Assessment Quality of Life-4 dimension (AQoL-4D) and the EuroQol-5 dimension 3 level (EQ-5D-3L). Only the HUI system was primarily developed for application with children/adolescents though health-state values for scoring the PROM were elicited from adults. The HUI-3 covered the most relevant constructs though it excludes important modules of health-related quality of life (HRQOL) such as activity limitations and participation restrictions. In terms of psychometric properties, evidence was presented for only five of COSMIN measurement properties: reliability (HUI3), measurement error (HUI-3), content validity (HUI-2 and HUI-3), Hypotheses testing (HUI-3 and AQoL-4D) and criterion validity (HUI-3). No papers reported on internal consistency, structural validity, cross-cultural validity or responsiveness of the preference-based measures in children and adolescents with cerebral palsy. This review highlights the dearth in studies using preference-based PROMs to measure HRQOL associated with cerebral palsy in children and adolescents. The HUI-3 demonstrated the strongest psychometric properties, though it does not cover all dimensions relevant to this population.

  4. Characteristics of children with cerebral palsy in the ORACLE children study.

    Science.gov (United States)

    Marlow, Neil; Pike, Katie; Bower, Eva; Brocklehurst, Peter; Jones, David; Kenyon, Sara; Kurinczuk, Jennifer J; Taylor, David; Salt, Alison

    2012-07-01

    We have identified an excess of children with cerebral palsy (CP) born to women who received antibiotic treatment for spontaneous preterm labour (SPL). This nested study investigated the profile of impairment among children with CP in the ORACLE Children Study (OCS), and contrasted outcomes with those in 4Child, a population CP registry. The study group comprised 167 children aged from 7 to 10 years (100 males, 67 females) with CP from the OCS, who were subdivided into a preterm rupture of membranes (PROM) group (87 children) and an SPL group (80 children). The OCS sought follow-up information regarding the health and behaviour of surviving children at 7 years of age in the UK using a parent-report postal questionnaire. Families provided further information to define wider aspects of function and were offered a physiotherapy assessment. The prevalence of CP was higher among children in the OCS than among those in 4Child (standardized morbidity ratios: SPL group, 3.12 [95% confidence interval {CI} 2.47-3.87); PROM group: 1.56 (CI 1.24-1.92)]. The proportion of children with CP born after 32 weeks of gestation was higher in in the SPL group (73%) than in the PROM group (30%); the prevalence of CP was higher in the SPL group than in the PROM group or 4Child. Children with CP in the OCS tended to have similar distributions of neuroimpairment as children in 4Child, but motor impairment and associated vision and hearing problems were found to be less severe. The pattern of CP in both the PROM and the SPL groups was similar, but functional outcomes were milder, compared with children with CP in the general population. However, in these groups the risk of CP was increased independently of gestational age. This is consistent with findings that ongoing inflammatory damage can cause CP. © The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press.

  5. Aging of intrauterine tissues in spontaneous preterm birth and preterm premature rupture of the membranes: A systematic review of the literature.

    Science.gov (United States)

    Polettini, J; Dutta, E H; Behnia, F; Saade, G R; Torloni, M R; Menon, R

    2015-09-01

    Many adverse pregnancy outcomes (APOs), including spontaneous preterm birth (PTB), are associated with placental dysfunction. Recent clinical and experimental evidences suggest that premature aging of the placenta may be involved in these events. Although placental aging is a well-known concept, the mechanisms of aging during normal pregnancy and premature aging in APOs are still unclear. This review was conducted to assess the knowledge on placental aging related biochemical changes leading to placental dysfunction in PTB and/or preterm premature rupture of membranes (pPROM). We performed a systematic review of studies published over the last 50 years in two electronic databases (Pubmed and Embase) on placental aging and PTB or pPROM. The search yielded 554 citations, 30 relevant studies were selected for full-text review and three were included in the review. Only one study reported oxidative stress-related aging and degenerative changes in human placental membranes and telomere length reduction in fetal cells as part of PTB and/or pPROM mechanisms. Similarly, two animal studies reported findings of decidual senescence and referred to PTB mechanisms. Placental and fetal membrane oxidative damage and telomere reduction are linked to premature aging in PTB and pPROM but the risk factors and biomolecular pathways causing this phenomenon are not established in the literature. However, no biomarkers or clinical indicators of premature aging as a pathology of PTB and pPROM have been reported. We document major knowledge gaps and propose several areas for future research to improve our understanding of premature aging linked to placental dysfunction. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. The association between preceding drought occurrence and heat waves in the Mediterranean

    Science.gov (United States)

    Russo, Ana; Gouveia, Célia M.; Ramos, Alexandre M.; Páscoa, Patricia; Trigo, Ricardo M.

    2017-04-01

    A large number of weather driven extreme events has occurred worldwide in the last decade, namely in Europe that has been struck by record breaking extreme events with unprecedented socio-economic impacts, including the mega-heatwaves of 2003 in Europe and 2010 in Russia, and the large droughts in southwestern Europe in 2005 and 2012. The last IPCC report on extreme events points that a changing climate can lead to changes in the frequency, intensity, spatial extent, duration, and timing of weather and climate extremes. These, combined with larger exposure, can result in unprecedented risk to humans and ecosystems. In this context it is becoming increasingly relevant to improve the early identification and predictability of such events, as they negatively affect several socio-economic activities. Moreover, recent diagnostic and modelling experiments have confirmed that hot extremes are often preceded by surface moisture deficits in some regions throughout the world. In this study we analyze if the occurrence of hot extreme months is enhanced by the occurrence of preceding drought events throughout the Mediterranean area. In order to achieve this purpose, the number of hot days in the regions' hottest month will be associated with a drought indicator. The evolution and characterization of drought was analyzed using both the Standardized Precipitation Evaporation Index (SPEI) and the Standardized Precipitation Index (SPI), as obtained from CRU TS3.23 database for the period 1950-2014. We have used both SPI and SPEI for different time scales between 3 and 9 months with a spatial resolution of 0.5°. The number of hot days and nights per month (NHD and NHN) was determined using the ECAD-EOBS daily dataset for the same period and spatial resolution (dataset v14). The NHD and NHN were computed, respectively, as the number of days with a maximum or minimum temperature exceeding the 90th percentile. Results show that the most frequent hottest months for the Mediterranean

  7. Stable isotope record in annually laminated lake sediments from Lake Żabińskie (NE Poland) for the last millennium.

    Science.gov (United States)

    Gabryś, Alicja; Piotrowska, Natalia; Tylmann, Wojciech; Bonk, Alicja; Filipiak, Janusz; Wacnik, Agnieszka; Hernandez-Almeida, Ivan; Grosjean, Martin

    2015-04-01

    Stable isotope record of carbon (13C) and oxygen (18O) has been analysed from an annually laminated sediment from Lake Zabinskie (Mazurian Lakeland, NE Poland) with high resolution (1-3 yrs). The sediment layers which were formed in each year during the last millennium contain information about environmental changes in the past. The calcite layers are formed in lake sediment in warm months of the year, therefore the reconstruction of summer climate variables in the past is potentially possible. The investigation of correlation between isotope dataset and instrumental climate data for years 1897-2008 AD confirmed that theory. The record of temperature, precipitation and SPEI (Standardised Precipitation Evaporation Index) coefficient, which is a combination of both temperature and precipitation, was tested. The strongest linear correlations were found for most samples for June, July, August (JJA) months but in some cases the correlation coefficient was stronger when also May was taken into account. For the whole 120-yrs series the correlation between δ18O and average JJA temperature is 0.007, average JJA precipitation is 0.16 and average JJA SPEI is 0.20. Analyzing the results for 1897-2008 we can distinguish period 1960-2008 with relevantly stronger correlations: R(temperature) = 0.19, R(precipitation) = 0.20 and R(SPEI) = 0.45. This period is connected with cessation of human activity close to Lake Zabinskie. Reconstruction of climate variables for the last millennium was made using transfer function obtained for calibration period (1897-2008). Reconstructions showed that known climate extremes like Medieval Warm Period, Little Ice Age with Sporer (1420-1570), Maunder (1645-1715) and Dalton (1790-1820) Minimum was recorded in sediment from Lake Zabinskie. The presented study is a part of the project "Climate of northern Poland during the last 1000 years: Constraining the future with the past (CLIMPOL)", funded within Polish-Swiss Research Programme. http://www.climpol.ug.edu.pl

  8. Contrasting impacts of continuous moderate drought and episodic severe droughts on the aboveground-biomass increment and litterfall of three coexisting Mediterranean woody species.

    Science.gov (United States)

    Liu, Daijun; Ogaya, Romà; Barbeta, Adrià; Yang, Xiaohong; Peñuelas, Josep

    2015-11-01

    Climate change is predicted to increase the aridity in the Mediterranean Basin and severely affect forest productivity and composition. The responses of forests to different timescales of drought, however, are still poorly understood because extreme and persistent moderate droughts can produce nonlinear responses in plants. We conducted a rainfall-manipulation experiment in a Mediterranean forest dominated by Quercus ilex, Phillyrea latifolia, and Arbutus unedo in the Prades Mountains in southern Catalonia from 1999 to 2014. The experimental drought significantly decreased forest aboveground-biomass increment (ABI), tended to increase the litterfall, and decreased aboveground net primary production throughout the 15 years of the study. The responses to the experimental drought were highly species-specific. A. unedo suffered a significant reduction in ABI, Q. ilex experienced a decrease during the early experiment (1999-2003) and in the extreme droughts of 2005-2006 and 2011-2012, and P. latifolia was unaffected by the treatment. The drought treatment significantly increased branch litterfall, especially in the extremely dry year of 2011, and also increased overall leaf litterfall. The drought treatment reduced the fruit production of Q. ilex, which affected seedling recruitment. The ABIs of all species were highly correlated with SPEI in early spring, whereas the branch litterfalls were better correlated with summer SPEIs and the leaf and fruit litterfalls were better correlated with autumn SPEIs. These species-specific responses indicated that the dominant species (Q. ilex) could be partially replaced by the drought-resistant species (P. latifolia). However, the results of this long-term study also suggest that the effect of drought treatment has been dampened over time, probably due to a combination of demographic compensation, morphological and physiological acclimation, and epigenetic changes. However, the structure of community (e.g., species composition

  9. Spatio-temporal seasonal drought patterns in Europe from 1950 to 2015

    Science.gov (United States)

    Spinoni, Jonathan; Naumann, Gustavo; Vogt, Jürgen

    2016-04-01

    Drought is one of the natural disasters with severe impacts in Europe, not only in areas which frequently experience water scarcity such as the Mediterranean, but also in temperate or continental climates such as Central and Eastern Europe and even in cold regions such as Scandinavia and Iceland. In this study the spatio-temporal patterns of seasonal meteorological droughts in Europe between 1950 and 2015 are investigated using the Standardized Precipitation Index (SPI) and the Standardized Precipitation-Evapotranspiration Index (SPEI). Since the focus is on the analysis of seasonal drought trends, indicators were calculated for 3 monthly accumulation periods. The input variables of precipitation and temperature were derived from E-OBS grids (v11-v12) at a spatial resolution of 0.25°x0.25°. Seasonal trends of drought frequency and severity were analyzed for moderate (SPI or SPEI 2.0) events during the periods 1950-2015 and 1981-2015. For the moderate events, results of the SPI analysis (precipitation driven) demonstrate a significant tendency towards less frequent and severe droughts in Northern Europe and Russia, especially in winter and spring; oppositely, an increasing trend is visible in Southern Europe, mainly in spring and summer. According to the SPEI analysis (precipitation and temperature driven) Northern Europe shows wetting patterns, while Southern and Eastern Europe show a more remarkable drying tendency, especially in summer and autumn for drought frequency and in every season for drought severity. The evolution towards drier conditions is more relevant from 1981 onwards, both in terms of frequency and severity. This is especially true for Central Europe in spring, for the Mediterranean in summer, and for Eastern Europe in autumn. Extreme events follow similar patterns, but in autumn no spatially coherent trend can be found.

  10. Siberian Pine Decline and Mortality in Southern Siberian Mountains

    Science.gov (United States)

    Kharuk, V. I.; Im, S. T.; Oskorbin, P. A.; Petrov, I. A.; Ranson, K. J.

    2013-01-01

    The causes and resulting spatial patterns of Siberian pine mortality in eastern Kuznetzky Alatau Mountains, Siberia were analyzed based on satellite (Landsat, MODIS) and dendrochronology data. Climate variables studied included temperature, precipitation and Standardized Precipitation-Evapotranspiration Index (SPEI) drought index. Landsat data analysis showed that stand mortality was first detected in the year 2006 at an elevation of 650 m, and extended up to 900 m by the year 2012. Mortality was accompanied by a decrease in MODIS derived vegetation index (EVI).. The area of dead stands and the upper mortality line were correlated with increased drought. The uphill margin of mortality was limited by elevational precipitation gradients. Dead stands (i.e., >75% tree mortality) were located mainly on southern slopes. With respect to slope, mortality was observed within a 7 deg - 20 deg range with greatest mortality occurring on convex terrain. Tree radial incrementmeasurements correlate and were synchronous with SPEI (r sq = 0.37, r(sub s) = 80). Increasing synchrony between tree ring growth and SPEI indicates that drought has reduced the ecological niche of Siberian pine. The results also showed the primary role of drought stress on Siberian pine mortality. A secondary role may be played by bark beetles and root fungi attacks. The observed Siberian pine mortality is part of a broader phenomenon of "dark needle conifers" (DNC, i.e., Siberian pine, fir and spruce) decline and mortality in European Russia, Siberia, and the Russian Far East. All locations of DNC decline coincided with areas of observed drought increase. The results obtained are one of the first observations of drought-induced decline and mortality of DNC at the southern border of boreal forests. Meanwhile if model projections of increased aridity are correct DNC, within the southern part of its range may be replaced by drought-resistant Pinus silvestris and Larix sibirica.

  11. WRF added value to capture the spatio-temporal drought variability

    Science.gov (United States)

    García-Valdecasas Ojeda, Matilde; Quishpe-Vásquez, César; Raquel Gámiz-Fortis, Sonia; Castro-Díez, Yolanda; Jesús Esteban-Parra, María

    2017-04-01

    Regional Climate Models (RCM) has been widely used as a tool to perform high resolution climate fields in areas with high climate variability such as Spain. However, the outputs provided by downscaling techniques have many sources of uncertainty associated at different aspects. In this study, the ability of the Weather Research and Forecasting (WRF) model to capture drought conditions has been analyzed. The WRF simulation was carried out for a period that spanned from 1980 to 2010 over a domain centered in the Iberian Peninsula with a spatial resolution of 0.088°, and nested in the coarser EURO-CORDEX domain (0.44° spatial resolution). To investigate the spatiotemporal drought variability, the Standardized Precipitation Index (SPI) and the Standardized Precipitation Evapotranspiration Index (SPEI) has been computed at two different timescales: 3- and 12-months due to its suitability to study agricultural and hydrological droughts. The drought indices computed from WRF outputs were compared with those obtained from the observational (MOTEDAS and MOPREDAS) datasets. In order to assess the added value provided by downscaled fields, these indices were also computed from the ERA-Interim Re-Analysis database, which provides the lateral and boundary conditions of the WRF simulations. Results from this study indicate that WRF provides a noticeable benefit with respect to ERA-Interim for many regions in Spain in terms of drought indices, greater for SPI than for SPEI. The improvement offered by WRF depends on the region, index and timescale analyzed, being greater at longer timescales. These findings prove the reliability of the downscaled fields to detect drought events and, therefore, it is a remarkable source of knowledge for a suitable decision making related to water-resource management. Keywords: Drought, added value, Regional Climate Models, WRF, SPEI, SPI. Acknowledgements: This work has been financed by the projects P11-RNM-7941 (Junta de Andalucía-Spain) and

  12. Influence of mathematical and physical background of drought indices on their complementarity and drought recognition ability

    Science.gov (United States)

    Frank, Anna; Armenski, Tanja; Gocic, Milan; Popov, Srdjan; Popovic, Ljiljana; Trajkovic, Slavisa

    2017-09-01

    The aim of this study is to test how effective and physically correct are the mathematical approaches of operational indices used by relevant National Agencies across the globe. To do so, the following indices were analysed Standardized Precipitation Index (SPI) -1, 3, 6, 12 and 24, Standardized Precipitation - Evapotranspiration Index (SPEI) - 1, 3, 6, 12 and 24, Effective Drought Index (EDI) and Index of Drying Efficiency of Air (IDEA). To make regions more comparable to each other and follow the spatial development of drought SPI index was advised by World Meteorological Organisation to be used widely by official meteorological services. The SPI and SPEI are used for Drought Early Warning in the USA, National Drought Mitigation Center and NASA, and in the EU by the European Drought Centre (EDC) and in the Balkan Region by National Meteorological Agencies. The EDI Index has wide application in Asia. In this paper four different issues were investigated: 1) how the mathematical method used in a drought indicator's computation influence drought indices' (DI) comparative analyses; 2) the sensitivity of the DIs on any change of the length of observational period; 3) similarities between the DIs time series; 4) and how accurate DIs are when compared to historical drought records. Results suggest that it is necessary to apply a few crucial changes in the Drought Monitoring and Early Warning Systems: 1) reconsider use of SPI and SPEI family indices as a measure of quality of other indices; and for Drought Early Recognition Programs 2) switch to DIs with a solid physical background, such as EDI; 3) Adopt solid physics for modelling drought processes and define the physical measure of drought, e.g. EDI and IDEA indices; 4) investigate further the IDEA index, which, supported by our study as well, is valuable for simulation of a drought process.

  13. Agricultural drought prediction using climate indices based on Support Vector Regression in Xiangjiang River basin.

    Science.gov (United States)

    Tian, Ye; Xu, Yue-Ping; Wang, Guoqing

    2018-05-01

    Drought can have a substantial impact on the ecosystem and agriculture of the affected region and does harm to local economy. This study aims to analyze the relation between soil moisture and drought and predict agricultural drought in Xiangjiang River basin. The agriculture droughts are presented with the Precipitation-Evapotranspiration Index (SPEI). The Support Vector Regression (SVR) model incorporating climate indices is developed to predict the agricultural droughts. Analysis of climate forcing including El Niño Southern Oscillation and western Pacific subtropical high (WPSH) are carried out to select climate indices. The results show that SPEI of six months time scales (SPEI-6) represents the soil moisture better than that of three and one month time scale on drought duration, severity and peaks. The key factor that influences the agriculture drought is the Ridge Point of WPSH, which mainly controls regional temperature. The SVR model incorporating climate indices, especially ridge point of WPSH, could improve the prediction accuracy compared to that solely using drought index by 4.4% in training and 5.1% in testing measured by Nash Sutcliffe efficiency coefficient (NSE) for three month lead time. The improvement is more significant for the prediction with one month lead (15.8% in training and 27.0% in testing) than that with three months lead time. However, it needs to be cautious in selection of the input parameters, since adding redundant information could have a counter effect in attaining a better prediction. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Characterizing the Water Balance of the Sooke Reservoir, British Columbia over the Last Century

    Directory of Open Access Journals (Sweden)

    Arelia T. Werner

    2015-03-01

    Full Text Available Infrastructure such as dams and reservoirs are critical water-supply features in several regions of the world. However, ongoing population growth, increased demand and climate variability/change necessitate the better understanding of these systems, particularly in terms of their long-term trends. The Sooke Reservoir (SR of British Columbia, Canada is one such reservoir that currently supplies water to ~300,000 people, and is subject to considerable inter and intra-annual climatic variations. The main objectives of this study are to better understand the characteristics of the SR through an in-depth assessment of the contemporary water balance when the basin was intensively monitored (1996–2005, to use standardized runoff to select the best timescale to compute the Standard Precipitation (SPI and Standard Precipitation Evaporation Indices (SPEI to estimate trends in water availability over 1919 to 2005. Estimates of runoff and evaporation were validated by comparing simulated change in storage, computed by adding inputs and subtracting outputs from the known water levels by month, to observed change in storage. Water balance closure was within ±11% of the monthly change in storage on average when excluding months with spill pre-2002. The highest evaporation, dry season (1998 and lowest precipitation, wet season (2000/2001 from the intensively monitored period were used to construct a worst-case scenario to determine the resilience of the SR to drought. Under such conditions, the SR could support Greater Victoria until the start of the third wet season. The SPEI and SPI computed on a three-month timescale had the highest correlation with the standardized runoff, R2 equaled 0.93 and 0.90, respectively. A trend toward drier conditions was shown by SPEI over 1919 to 2005, while moistening over the same period was shown by SPI, although trends were small in magnitude. This study contributes a validated application of SPI and SPEI, giving more

  15. The influence of antecedent conditions on flood risk in sub-Saharan Africa

    Science.gov (United States)

    Bischiniotis, Konstantinos; van den Hurk, Bart; Coughlan de Perez, Erin; Jongman, Brenden; Veldkamp, Ted; Aerts, Jeroen

    2017-04-01

    Traditionally, flood risk management has focused on long-term flood protection measures. However, many countries are often not able to afford hard infrastructure that provides sufficient safety levels due to the high investment costs. As a consequence, they rely more on post disaster response and timely warning systems. Most early warning systems have predominantly focused on precipitation as the main predictive factor, having usually lead times of hours or days. However, other variables could also play a role. For instance, anomalous positive water storage, soil saturation and evapotranspiration are physical factors that may influence the length of the flood build-up period. This period can vary from some days to several months before the event and it is particularly important in flood risk management since longer flood warning lead times during this period could result in better flood preparation actions. This study addresses how the antecedent conditions of historical reported flood events over the period 1980 to 2010 in sub-Saharan Africa relate to flood generation. The seasonal-scale conditions are reflected in the Standardized Precipitation Evapotranspiration Index (SPEI), which is calculated using monthly precipitation and temperature data and accounts for the wetness/dryness of an area. Antecedent conditions are separated into a) a short term 'weather-scale' period (0-7 days) and b) a 'seasonal-scale' period (up to 6 months) before the flood event in such a way that they do not overlap. Total 7-day precipitation, which is based on daily meteorological data, was used to evaluate the short-term weather-scale conditions. Using a pair of coordinates, derived from the NatCatSERVICE database on global flood losses, each flood event is positioned on a 0.5°x 0.5° grid cell. The antecedent SPEI conditions of the two periods and their joint influence in flood generation are compared to the same period conditions of the other years of the dataset. First results

  16. The impacts of key adverse weather events on the field-grown vegetable yield variability in the Czech Republic from 1961 to 2014

    Czech Academy of Sciences Publication Activity Database

    Potopová, V.; Zahradníček, Pavel; Štěpánek, Petr; Türkott, L.; Farda, Aleš; Soukup, J.

    2017-01-01

    Roč. 37, č. 3 (2017), s. 1648-1664 ISSN 0899-8418 R&D Projects: GA MŠk(CZ) LO1415; GA ČR GA13-19831S; GA MŠk(CZ) LD14043 Institutional support: RVO:67179843 Keywords : vegetable crops * yield losses * dry days * dry spells * extended dry spells * heavy precipitation * heat stress * heat wave * evapotranspiration * drought indices (SPI/SPEI scPDSI/scZ-index) Subject RIV: DG - Athmosphere Sciences, Meteorology OBOR OECD: Meteorology and atmospheric sciences Impact factor: 3.760, year: 2016

  17. Time-lagged effects of weather on plant demography: drought and Astragalus scaphoides.

    Science.gov (United States)

    Tenhumberg, Brigitte; Crone, Elizabeth E; Ramula, Satu; Tyre, Andrew J

    2018-04-01

    Temperature and precipitation determine the conditions where plant species can occur. Despite their significance, to date, surprisingly few demographic field studies have considered the effects of abiotic drivers. This is problematic because anticipating the effect of global climate change on plant population viability requires understanding how weather variables affect population dynamics. One possible reason for omitting the effect of weather variables in demographic studies is the difficulty in detecting tight associations between vital rates and environmental drivers. In this paper, we applied Functional Linear Models (FLMs) to long-term demographic data of the perennial wildflower, Astragalus scaphoides, and explored sensitivity of the results to reduced amounts of data. We compared models of the effect of average temperature, total precipitation, or an integrated measure of drought intensity (standardized precipitation evapotranspiration index, SPEI), on plant vital rates. We found that transitions to flowering and recruitment in year t were highest if winter/spring of year t was wet (positive effect of SPEI). Counterintuitively, if the preceding spring of year t - 1 was wet, flowering probabilities were decreased (negative effect of SPEI). Survival of vegetative plants from t - 1 to t was also negatively affected by wet weather in the spring of year t - 1 and, for large plants, even wet weather in the spring of t - 2 had a negative effect. We assessed the integrated effect of all vital rates on life history performance by fitting FLMs to the asymptotic growth rate, log(λt). Log(λt) was highest if dry conditions in year t - 1 were followed by wet conditions in the year t. Overall, the positive effects of wet years exceeded their negative effects, suggesting that increasing frequency of drought conditions would reduce population viability of A. scaphoides. The drought signal weakened when reducing the number of monitoring years. Substituting space for time

  18. Regional applicability of seven meteorological drought indices in China

    Institute of Scientific and Technical Information of China (English)

    YANG Qing; LI MingXing; ZHENG ZiYan; MA ZhuGuo

    2017-01-01

    The definition of a drought index is the foundation of drought research.However,because of the complexity of drought,there is no a unified drought index appropriate for different drought types and objects at the same time.Therefore,it is crucial to determine the regional applicability of various drought indices.Using terrestrial water storage obtained from the Gravity Recovery And Climate Experiment,and the observed soil moisture and streamflow in China,we evaluated the regional applicability of seven meteorological drought indices:the Palmer Drought Severity Index(PDSI),modified PDSI(PDSI_CN) based on observations in China,self-calibrating PDSI(scPDSI),Surface Wetness Index(SWI),Standardized Precipitation Index(SPI),Standardized Precipitation Evapotranspiration Index(SPEI),and soil moisture simulations conducted using the community land model driven by observed atmospheric forcing(CLM3.5/ObsFC).The results showed that the scPDSI is most appropriate for China.However,it should be noted that the scPDSI reduces the value range slightly compared with the PDSI and PDSI_CN;thus,the classification of dry and wet conditions should be adjusted accordingly.Some problems might exist when using the PDSI and PDSI_CN in humid and arid areas because of the unsuitability of empiricalparameters.The SPI and SPEI are more appropriate for humid areas than arid and semiarid areas.This is because contributions of temperature variation to drought are neglected in the SPI,but overestimated in the SPEI,when potential evapotranspiration is estimated by the Thornthwaite method in these areas.Consequently,the SPI and SPEI tend to induce wetter and drier results,respectively.The CLM3.5/ObsFC is suitable for China before 2000,but not for arid and semiarid areas after 2000.Consistent with other drought indices,the SWI shows similar interannual and decadal change characteristics in detecting annual dry/wet variations.Although the long-term trends of drought areas in China detected by these seven

  19. Assessment of Humidity Conditions and Trends Based on Standardized Precipitation Evapotranspiration Index (SEPI Over Different Climatic Regions of Iran

    Directory of Open Access Journals (Sweden)

    Mohammad Ghabaei S

    2017-01-01

    Full Text Available Introduction: Drought is a recurrent feature of climate that caused by deficiency of precipitation over time. Due to the rise in water demand and alarming climate change, recent year’s observer much focus on drought and drought conditions. A multiple types of deficits and relevant temporal scales can be achieved through the construction of a joint indicator that draws on information from multiple sources and will therefore enable better assessment of drought characteristics including return period, persistent and severity. The Standardized Precipitation Evapotranspiration Index (SPEI combines information from precipitation and temperature in the form of water surplus or deficit according to Standardized Precipitation Index (SPI. Rainfall over some regions of Iran during some resent year was below average while mean and maximum temperatures were very high during this period, as was evaporation. This would suggest that drought conditions were worse than in previous recent periods with similarly low rainfall. The main objective of this study is to assess the influences of humidity on the SPEI index and investigate its relation with SPI and Reconnaissance Drought Index (RDI over six different climatic regions in Iran. Materials and Methods: Iran has different climatic conditions which vary from desert in central part to costal wet near the Caspian Sea. In this study the selection of stations was done based on Alijani et al (2008 climatic classification. We chose 11 synoptic stations from six different climatic classes including costal wet (Rasht and Babolsar, semi mountains (Mashhad and Tabriz, mountains (Shiraz and Khoram Abad, semi-arid (Tehran and Semnan, arid (Kerman and Yazd and costal desert (Bandar Abas. The Meteorological datasets for the aforementioned stations were obtained from the Iran Meteorological Organization (IRIMO for the period 1960-2010. The compiled data included average monthly values of precipitation, minimum and maximum air

  20. Drought reconstruction based on grape harvest dates for the Czech Lands, 1499−2012

    Czech Academy of Sciences Publication Activity Database

    Možný, M.; Dobrovolný, Petr; Trnka, Miroslav; Potopová, V.; Hlavinka, Petr; Bartošová, Lenka; Zahradníček, Pavel; Štěpánek, Petr; Žalud, Zdeněk

    2016-01-01

    Roč. 70, 2-3 (2016), s. 119-132 ISSN 0936-577X R&D Projects: GA MŠk(CZ) LO1415; GA ČR GA13-19831S; GA ČR GA13-04291S Grant - others:EHP(CZ) EHP-CZ02-OV-1-014-2014 Program:CZ02 Institutional support: RVO:67179843 Keywords : Climate reconstruction * Drought * Grape harvest dates * SPEI * Bohemian wine-growing region Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 1.578, year: 2016

  1. Hydrogen mixing study (HMS) in LWR type containments

    International Nuclear Information System (INIS)

    Travis, J.R.

    1983-01-01

    A numerical technique has been developed for calculating the full three-dimensional time-dependent Navier-Stokes equations with multiple speies transport. The method is a modified form of the Implicit Continuous-fluid Eulerian (ICE) technique to solve the governing equations for low Mach number flows where pressure waves and local variations in compression and expansion are not significant. Large density variations, due to thermal and species concentration gradients, are accounted for without the restrictions of the classical Boussinesq approximation. Calculations of the EPRI/HEDL standard problems verify the feasibility of using this finite-difference technique for analyzing hydrogen mixing within LWR containments

  2. Feasibility test of a UK-scalable electronic system for regular collection of patient-reported outcome measures and linkage with clinical cancer registry data: The electronic Patient-reported Outcomes from Cancer Survivors (ePOCS system

    Directory of Open Access Journals (Sweden)

    Velikova Galina

    2011-10-01

    Full Text Available Abstract Background Cancer survivors can face significant physical and psychosocial challenges; there is a need to identify and predict which survivors experience what sorts of difficulties. As highlighted in the UK National Cancer Survivorship Initiative, routine post-diagnostic collection of patient reported outcome measures (PROMs is required; to be most informative, PROMs must be linked and analysed with patients' diagnostic and treatment information. We have designed and built a potentially cost-efficient UK-scalable electronic system for collecting PROMs via the internet, at regular post-diagnostic time-points, for linking these data with patients' clinical data in cancer registries, and for electronically managing the associated patient monitoring and communications; the electronic Patient-reported Outcomes from Cancer Survivors (ePOCS system. This study aims to test the feasibility of the ePOCS system, by running it for 2 years in two Yorkshire NHS Trusts, and using the Northern and Yorkshire Cancer Registry and Information Service. Methods/Design Non-metastatic breast, colorectal and prostate cancer patients (largest survivor groups, within 6 months post-diagnosis, will be recruited from hospitals in the Yorkshire Cancer Network. Participants will be asked to complete PROMS, assessing a range of health-related quality-of-life outcomes, at three time-points up to 15 months post-diagnosis, and subsequently to provide opinion on the ePOCS system via a feedback questionnaire. Feasibility will be examined primarily in terms of patient recruitment and retention rates, the representativeness of participating patients, the quantity and quality of collected PROMs data, patients' feedback, the success and reliability of the underpinning informatics, and the system running costs. If sufficient data are generated during system testing, these will be analysed to assess the health-related quality-of-life outcomes reported by patients, and to explore

  3. Are the patient-rated wrist evaluation (PRWE) and the disabilities of the arm, shoulder and hand (DASH) questionnaire used in distal radial fractures truly valid and reliable?

    Science.gov (United States)

    Krol, R. G.; Bhandari, M.; Goslings, J. C.; Poolman, R. W.; Scholtes, V. A. B.

    2018-01-01

    Objectives The patient-rated wrist evaluation (PRWE) and the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire are patient-reported outcome measures (PROMs) used for clinical and research purposes. Methodological high-quality clinimetric studies that determine the measurement properties of these PROMs when used in patients with a distal radial fracture are lacking. This study aimed to validate the PRWE and DASH in Dutch patients with a displaced distal radial fracture (DRF). Methods The intraclass correlation coefficient (ICC) was used for test-retest reliability, between PROMs completed twice with a two-week interval at six to eight months after DRF. Internal consistency was determined using Cronbach’s α for the dimensions found in the factor analysis. The measurement error was expressed by the smallest detectable change (SDC). A semi-structured interview was conducted between eight and 12 weeks after DRF to assess the content validity. Results A total of 119 patients (mean age 58 years (sd 15)), 74% female, completed PROMs at a mean time of six months (sd 1) post-fracture. One overall meaningful dimension was found for the PRWE and the DASH. Internal consistency was excellent for both PROMs (Cronbach’s α 0.96 (PRWE) and 0.97 (DASH)). Test-retest reliability was good for the PRWE (ICC 0.87) and excellent for the DASH (ICC 0.91). The SDC was 20 for the PRWE and 14 for the DASH. No floor or ceiling effects were found. The content validity was good for both questionnaires. Conclusion The PRWE and DASH are valid and reliable PROMs in assessing function and disability in Dutch patients with a displaced DRF. However, due to the high SDC, the PRWE and DASH are less useful for individual patients with a distal radial fracture in clinical practice. Cite this article: Y. V. Kleinlugtenbelt, R. G. Krol, M. Bhandari, J. C. Goslings, R. W. Poolman, V. A. B. Scholtes. Are the patient-rated wrist evaluation (PRWE) and the disabilities of the arm, shoulder and

  4. Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group.

    Science.gov (United States)

    Kenyon, S L; Taylor, D J; Tarnow-Mordi, W

    2001-03-31

    Preterm, prelabour rupture of the fetal membranes (pPROM) is the commonest antecedent of preterm birth, and can lead to death, neonatal disease, and long-term disability. Previous small trials of antibiotics for pPROM suggested some health benefits for the neonate, but the results were inconclusive. We did a randomised multicentre trial to try to resolve this issue. 4826 women with pPROM were randomly assigned 250 mg erythromycin (n=1197), 325 mg co-amoxiclav (250 mg amoxicillin plus 125 mg clavulanic acid; n=1212), both (n=1192), or placebo (n=1225) four times daily for 10 days or until delivery. The primary outcome measure was a composite of neonatal death, chronic lung disease, or major cerebral abnormality on ultrasonography before discharge from hospital. Analysis was by intention to treat. Two women were lost to follow-up, and there were 15 protocol violations. Among all 2415 infants born to women allocated erythromycin only or placebo, fewer had the primary composite outcome in the erythromycin group (151 of 1190 [12.7%] vs 186 of 1225 [15.2%], p=0.08) than in the placebo group. Among the 2260 singletons in this comparison, significantly fewer had the composite primary outcome in the erythromycin group (125 of 1111 [11.2%] vs 166 of 1149 [14.4%], p=0.02). Co-amoxiclav only and co-amoxiclav plus erythromycin had no benefit over placebo with regard to this outcome in all infants or in singletons only. Use of erythromycin was also associated with prolongation of pregnancy, reductions in neonatal treatment with surfactant, decreases in oxygen dependence at 28 days of age and older, fewer major cerebral abnormalities on ultrasonography before discharge, and fewer positive blood cultures. Although co-amoxiclav only and co-amoxiclav plus erythromycin were associated with prolongation of pregnancy, they were also associated with a significantly higher rate of neonatal necrotising enterocolitis. Erythromycin for women with pPROM is associated with a range of health

  5. Reductions and conservation laws for BBM and modified BBM equations

    Directory of Open Access Journals (Sweden)

    Khorshidi Maryam

    2016-01-01

    Full Text Available In this paper, the classical Lie theory is applied to study the Benjamin-Bona-Mahony (BBM and modified Benjamin-Bona-Mahony equations (MBBM to obtain their symmetries, invariant solutions, symmetry reductions and differential invariants. By observation of the the adjoint representation of Mentioned symmetry groups on their Lie algebras, we find the primary classification (optimal system of their group-invariant solutions which provides new exact solutions to BBM and MBBM equations. Finally, conservation laws of the BBM and MBBM equations are presented. Some aspects of their symmetry properties are given too.

  6. Feasibility of the collection of patient-reported outcomes in an ambulatory neurology clinic.

    Science.gov (United States)

    Moura, Lidia M V R; Schwamm, Eli; Moura Junior, Valdery; Seitz, Michael P; Hsu, John; Cole, Andrew J; Schwamm, Lee H

    2016-12-06

    To determine whether patients could self-report physical and mental health assessments in the waiting room and whether these assessments would be associated with modified Rankin Scale (mRS) and Quality of Life in Epilepsy (QOLIE-10) scores. We offered iPad-based surveys to consecutive adult neurology patients at check-in to collect patient-reported outcome measures (PROMs). We collected demographic and clinical data on 6,075 patients through survey or administrative claims and PROMs from participating patients. We compared demographic characteristics of participants and nonparticipants and tested associations between physical and mental health scores and mRS and QOLIE-10. Of 6,075 patients seen by neurologists during the study period, 2,992 (49.3%) participated in the survey. Compared to nonparticipating patients, participating patients more often were privately insured (53.5% vs 42.7%, p neurology (nonsubspecialty) clinics (53.1% vs 46.6%, p Neurology.

  7. Remarks about the prognosis in case of antenatal diagnosis of gastroschisis.

    Science.gov (United States)

    Poulain, P; Milon, J; Frémont, B; Proudhon, J F; Odent, S; Babut, J M; Le Marec, B; Grall, J Y; Giraud, J R

    1994-05-18

    We report our experience of 15 cases of gastroschisis which occurred between 1981 and 1993. All but one were diagnosed antenatally by ultrasound between 16 and 32 weeks of pregnancy. We made a termination of the pregnancy in 3 cases, for multiple malformations in 2 cases and one case of very early premature rupture of the membranes (PROM). When checked (11 cases), the karyotype was normal. We made a cesarean section in 11 cases: the indication was a complication for 6 (fetal distress, PROM, polyhydramnios, large dilatation of the gut). We noted growth retardation in 7 newborns and prematurity in 5/12 (mean gestational age of 36.8 weeks). The preoperative study of the gut noted 5 cases with intestinal damage and one case of complete necrosis of the gut. The global prognosis is not as good as usual, with a perinatal mortality of 41.6% (5/12). We discuss this latter point and examine the literature.

  8. Do different types of bearings and noise from total hip arthroplasty influence hip-related pain, function, and quality of life postoperatively?

    DEFF Research Database (Denmark)

    Varnum, Claus; Pedersen, Alma B; Kjærsgaard-Andersen, Per

    2016-01-01

    with metal-on-metal (MoM) THAs to scores from patients with metal-on-polyethylene (MoP) THAs, and to determine the influence of THA-related noise on PROM scores. Patients and methods - We conducted a nationwide cross-sectional questionnaire survey in a cohort of patients identified from the Danish Hip......, and 12% with MoP THAs reported noise from their hip. For the 3 types of bearings, PROM scores from patients with a noisy THA were statistically significantly worse than those from patients with a silent MoP THA. The exception was noisy CoC and MoM THAs, which had the same mean UCLA activity score...

  9. Danish Hip Arthroscopy Registry (DHAR)

    DEFF Research Database (Denmark)

    Lund, Bent; Mygind-Klavsen, Bjarne; Grønbech Nielsen, Torsten

    2017-01-01

    The Danish Hip Arthroscopy Registry (DHAR) was initiated in January 2012 as a web-based prospective registry. The purpose of this study was to evaluate and report the first registry based outcome data of a national population with radiological and clinical femoroacetabular impingement (FAI......) undergoing hip arthroscopic treatment. Our primary hypothesis was that patients undergoing hip arthroscopy would improve significantly in pain, quality of life and sports related outcome measurements in Patient Related Outcome Measures (PROM). Peri-operative data and Patient Reported Outcome Measures (PROM......-5 D demonstrated improvement after 1 and 2 years from 0.66 pre-op to 0.78 at 2 years. HSAS improved significantly from 2.5 to 3.3. Pain score data demonstrated improvement in NRS-rest 39 to 17 and NRS Walk 49 to 22 at follow-up. We conclude that patients with FAI undergoing hip arthroscopy...

  10. A systematic review of measurement properties of patient reported outcome measures in psoriatic arthritis

    DEFF Research Database (Denmark)

    Højgaard, Pil; Klokker, Louise; Orbai, Ana Maria

    2018-01-01

    Background: An updated psoriatic arthritis (PsA) core outcome set (COS) for randomized controlled trials (RCTs) was endorsed at the Outcome Measures in Rheumatology (OMERACT) meeting in 2016. Objectives: To synthesize the evidence on measurement properties of patient reported outcome measures...... (PROMs) for PsA and thereby contribute to development of a PsA core outcome measurement set (COMS) as described by the OMERACT Filter 2.0. Methods: A systematic literature search was performed in EMBASE, MEDLINE and PsycINFO on Jan 1, 2017 to identify full-text articles with an aim of assessing...... the measurement properties of PROMs in PsA. Two independent reviewers rated the quality of studies using the COnsensus based standards for the Selection of health Measurement INstruments (COSMIN) checklist, and performed a qualitative evidence synthesis. Results: Fifty-five studies were included in the systematic...

  11. Cross-cultural and construct validity of the Animated Activity Questionnaire

    DEFF Research Database (Denmark)

    Peter, Wilfred F; Cw de Vet, Henrika; Boers, Maarten

    2017-01-01

    OBJECTIVE: The Animated Activity Questionnaire (AAQ) assesses activity limitations in patients with hip/knee osteoarthritis (HKOA), and consisting video animations of which patients choose the animation that best matches their own performance. The AAQ has shown good validity and reliability......, and a Patient Reported Outcome Measure (PROM) and performance-based tests. RESULTS: Data of 1239 patients were available. Compared to Dutch (n=279), none of the 17 items showed DIF in English (n=202), French (n=193), 1 item showed uniform DIF in Spanish (n=99) and Norwegian (n=62), and 2 items showed uniform...... with the cross-cultural validity between these countries. With regard to construct validity, the correlations with PROM (0.74) and performance-based tests (0.36-0.68) were partly as expected (> 0.60). CONCLUSION: The AAQ, an innovative tool to measure activity limitations that can be placed on the continuum...

  12. Practice Bulletin No. 172: Premature Rupture of Membranes.

    Science.gov (United States)

    2016-10-01

    Preterm delivery occurs in approximately 12% of all births in the United States and is a major factor that contributes to perinatal morbidity and mortality (1, 2). Preterm premature rupture of membranes (PROM) complicates approximately 3% of all pregnancies in the United States (3). The optimal approach to clinical assessment and treatment of women with term and preterm PROM remains controversial. Management hinges on knowledge of gestational age and evaluation of the relative risks of delivery versus the risks of expectant management (eg, infection, abruptio placentae, and umbilical cord accident). The purpose of this document is to review the current understanding of this condition and to provide management guidelines that have been validated by appropriately conducted outcome-based research when available. Additional guidelines on the basis of consensus and expert opinion also are presented.

  13. Use of a Multivector Mandibular Distractor for Treatment of Pediatric Proximal Interphalangeal Joint Pilon Fractures: A Case-Based Review.

    Science.gov (United States)

    Pedreira, Rachel; Cho, Brian H; Geer, Angela; DeJesus, Ramon A

    2018-04-01

    The difficulties in surgical treatment of pilon fractures of the finger include fragment reconstitution and posthealing stiffness. In adults, external fixation with traction and early active range of motion (AROM)/passive range of motion (PROM) during healing is considered necessary for avoiding joint stiffness and attaining realignment. The authors present a unique approach to pediatric pilon fractures that uses open reduction and multivector external fixation with delayed AROM/PROM. Initial immobilization and significant traction allowed for joint realignment and prevented noncompliance with staged distraction. The authors believe this immobilization leads to a superior outcome because, unlike adults, children tend to avoid stiffness and a larger distraction force allowed for sufficient joint realignment to regain range of motion (ROM). A right-handed 13-year-old boy sustained a right ring finger fracture and presented 12 days later. Radiographs revealed a comminuted Salter-Harris 4 fracture of the middle phalanx. The patient underwent open reduction and placement of multivector external fixation using a pediatric mandibular distractor/fixator. Significant traction was applied to distract the finger to length. Hardware was removed 6 weeks postoperatively and AROM was initiated after splinting. The patient started PROM 8 weeks postoperatively. Strengthening was initiated 2 weeks later. ROM improved and rehabilitation was continued. The patient exhibited nearly equal grip strength 12 weeks postoperatively. At 14 months follow-up, radiographs showed complete healing and joint realignment. There was no deformity or pain and finger length was restored. Management of pediatric pilon fractures is rarely described and presents unique considerations. Early-stage traction and immobilization using a multivector mandibular fixator/distractor is suitable in a child because noncompliance is avoided and there is a decreased risk for stiffness. Combining early immobilization

  14. Raising the profile of pilot and feasibility studies in relation to the development, evaluation and implementation of patient-reported outcome measures.

    OpenAIRE

    Jones, GL

    2017-01-01

    This editorial introduces a new special series on the pilot and feasibility testing of patient-reported outcome measures (PROMs) in the on-line open access journal Pilot and Feasibility Studies. Pilot and feasibility studies are typically implemented to address issues of uncertainty before undertaking a larger definitive study such as a randomised controlled trial or large scale survey. This editorial considers the role that such pilot and feasibility testing plays in relation to the developm...

  15. Experience of Soviet Medicine in a Great Patriotic War, 1941-1945. Volume 16, Section 2.

    Science.gov (United States)

    1980-10-22

    arthritis . (6). Suppurativq flod. . •--. - ++ - DOC 80093616 PAGE (7). Thrombophlebitis. Id). TaromDosis of arteries. (9). Secondary hemorrhage. (10...frequently wece accompaniea by arthritis of radiocarpal joint, by finished ankylosis of lattir and by heavy disturbances/breakdowns of functions of hand...antiseptic substances in the form of solutions and emulsions, and also physiotherapy and therapeutic gymnastics. Prom the antiseptic substances they were

  16. Programmable synchronous communications module

    International Nuclear Information System (INIS)

    Horelick, D.

    1979-10-01

    The functional characteristics of a programmable, synchronous serial communications CAMAC module with buffering in block format are described. Both bit and byte oriented protocols can be handled in full duplex depending on the program implemented. The main elements of the module are a Signetics 2652 Multi-Protocol Communications Controller, a Zilog Z-808 8 bit microprocessor with PROM and RAM, and FIFOs for buffering

  17. The Cervical Dystonia Impact Profile (CDIP-58: Can a Rasch developed patient reported outcome measure satisfy traditional psychometric criteria?

    Directory of Open Access Journals (Sweden)

    Bhatia Kailash P

    2008-08-01

    Full Text Available Abstract Background The United States Food and Drug Administration (FDA are currently producing guidelines for the scientific adequacy of patient reported outcome measures (PROMs in clinical trials, which will have implications for the selection of scales used in future clinical trials. In this study, we examine how the Cervical Dystonia Impact Profile (CDIP-58, a rigorous Rasch measurement developed neurologic PROM, stands up to traditional psychometric criteria for three reasons: 1 provide traditional psychometric evidence for the CDIP-58 in line with proposed FDA guidelines; 2 enable researchers and clinicians to compare it with existing dystonia PROMs; and 3 help researchers and clinicians bridge the knowledge gap between old and new methods of reliability and validity testing. Methods We evaluated traditional psychometric properties of data quality, scaling assumptions, targeting, reliability and validity in a group of 391 people with CD. The main outcome measures used were the CDIP-58, Medical Outcome Study Short Form-36, the 28-item General Health Questionnaire, and Hospital and Anxiety and Depression Scale. Results A total of 391 people returned completed questionnaires (corrected response rate 87%. Analyses showed: 1 data quality was high (low missing data ≤ 4%, subscale scores could be computed for > 96% of the sample; 2 item groupings passed tests for scaling assumptions; 3 good targeting (except for the Sleep subscale, ceiling effect = 27%; 4 good reliability (Cronbach's alpha ≥ 0.92, test-retest intraclass correlations ≥ 0.83; and 5 validity was supported. Conclusion This study has shown that new psychometric methods can produce a PROM that stands up to traditional criteria and supports the clinical advantages of Rasch analysis.

  18. Patient-reported outcome measures versus inertial performance-based outcome measures: A prospective study in patients undergoing primary total knee arthroplasty.

    Science.gov (United States)

    Bolink, S A A N; Grimm, B; Heyligers, I C

    2015-12-01

    Outcome assessment of total knee arthroplasty (TKA) by subjective patient reported outcome measures (PROMs) may not fully capture the functional (dis-)abilities of relevance. Objective performance-based outcome measures could provide distinct information. An ambulant inertial measurement unit (IMU) allows kinematic assessment of physical performance and could potentially be used for routine follow-up. To investigate the responsiveness of IMU measures in patients following TKA and compare outcomes with conventional PROMs. Patients with end stage knee OA (n=20, m/f=7/13; age=67.4 standard deviation 7.7 years) were measured preoperatively and one year postoperatively. IMU measures were derived during gait, sit-stand transfers and block step-up transfers. PROMs were assessed by using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Knee Society Score (KSS). Responsiveness was calculated by the effect size, correlations were calculated with Spearman's rho correlation coefficient. One year after TKA, patients performed significantly better at gait, sit-to-stand transfers and block step-up transfers. Measures of time and kinematic IMU measures demonstrated significant improvements postoperatively for each performance-based test. The largest improvement was found in block step-up transfers (effect size=0.56-1.20). WOMAC function score and KSS function score demonstrated moderate correlations (Spearman's rho=0.45-0.74) with some of the physical performance-based measures pre- and postoperatively. To characterize the changes in physical function after TKA, PROMs could be supplemented by performance-based measures, assessing function during different activities and allowing kinematic characterization with an ambulant IMU. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Influence of the mental health status on a new measure of objective functional impairment in lumbar degenerative disc disease.

    Science.gov (United States)

    Stienen, Martin N; Smoll, Nicolas R; Joswig, Holger; Snagowski, Jan; Corniola, Marco V; Schaller, Karl; Hildebrandt, Gerhard; Gautschi, Oliver P

    2017-06-01

    The Timed Up and Go (TUG) test has recently been proposed as a simple and standardized measure for objective functional impairment (OFI) in patients with lumbar degenerative disc disease (DDD). The study aimed to explore the relationship between a patient's mental health status and both patient-reported outcome measures (PROMs) and TUG test results. This is a prospective institutional review board-approved two-center study. The sample was composed of 375 consecutive patients scheduled for lumbar spine surgery and a healthy cohort of 110 control subjects. Patients and control subjects were assessed with the TUG test and a comprehensive panel of subjective PROMs of pain intensity (visual analog scale [VAS]), functional impairment (Roland-Morris Disability Index [RMDI]), Oswestry Disability Index [ODI]), as well as health-related quality of life (hrQoL; Euro-Qol [EQ]-5D). Standardized age- and sex-adjusted TUG test T-scores were calculated. The dependent variable was the short-form (SF)-12 mental component summary (MCS) quartiles, and the independent variables were the TUG T-scores and PROMs. Direct and adjusted analyses of covariance were performed to estimate the interaction between the SF-12 MCS quartiles and the independent variables. In patients, there was a significant decrease in the subjective PROMs, notably the VAS back pain (p=.001) and VAS leg pain (p=.035), as well as significant increase in the RMDI (pmental hrQoL on subjective measures of pain, functional impairment, and hrQoL that might lead to bias when evaluating patients with lumbar DDD who suffer from reduced mental hrQoL. The TUG test appears to be a stable instrument and especially helpful in the evaluation of patients with lumbar DDD and mental health problems. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. MRC ORACLE Children Study. Long term outcomes following prescription of antibiotics to pregnant women with either spontaneous preterm labour or preterm rupture of the membranes

    Directory of Open Access Journals (Sweden)

    Salt Alison

    2008-04-01

    Full Text Available Abstract Background The Medical Research Council (MRC ORACLE trial evaluated the use of co-amoxiclav 375 mg and/or erythromycin 250 mg in women presenting with preterm rupture of membranes (PROM ORACLE I or in spontaneous preterm labour (SPL ORACLE II using a factorial design. The results showed that for women with a singleton baby with PROM the prescription of erythromycin is associated with improvements in short term neonatal outcomes, although co-amoxiclav is associated with prolongation of pregnancy, a significantly higher rate of neonatal necrotising enterocolitis was found in these babies. Prescription of erythromycin is now established practice for women with PROM. For women with SPL antibiotics demonstrated no improvements in short term neonatal outcomes and are not recommended treatment. There is evidence that both these conditions are associated with subclinical infection so perinatal antibiotic administration may reduce the risk of later disabilities, including cerebral palsy, although the risk may be increased through exposure to inflammatory cytokines, so assessment of longer term functional and educational outcomes is appropriate. Methods The MRC ORACLE Children's Study will follow up UK children at age 7 years born to 4809 women with PROM and the 4266 women with SPL enrolled in the earlier ORACLE trials. We will use a parental questionnaire including validated tools to assess disability and behaviour. We will collect the frequency of specific medical conditions: cerebral palsy, epilepsy, respiratory illness including asthma, diabetes, admission to hospital in last year and other diseases, as reported by parents. National standard test results will be collected to assess educational attainment at Key Stage 1 for children in England. Discussion This study is designed to investigate whether or not peripartum antibiotics improve health and disability for children at 7 years of age. Trial registration The ORACLE Trial and Children