Sample records for prolonged extraterrestrial missions
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Planetary Protection Knowledge Gaps for Human Extraterrestrial Missions: Workshop Report
Race, Margaret S. (Editor); Johnson, James E. (Editor); Spry, James A. (Editor); Siegel, Bette; Conley, Catharine A.
2015-01-01
This report on Planetary Protection Knowledge Gaps for Human Extraterrestrial Missions summarizes the presentations, deliberations and findings of a workshop at NASA Ames Research Center, March 24-26, 2015, which was attended by more than 100 participants representing a diverse mix of science, engineering, technology, and policy areas. The main objective of the three-day workshop was to identify specific knowledge gaps that need to be addressed to make incremental progress towards the development of NASA Procedural Requirements (NPRs) for Planetary Protection during human missions to Mars.
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Curating NASA's Past, Present, and Future Extraterrestrial Sample Collections
McCubbin, F. M.; Allton, J. H.; Evans, C. A.; Fries, M. D.; Nakamura-Messenger, K.; Righter, K.; Zeigler, R. A.; Zolensky, M.; Stansbery, E. K.
2016-01-01
The Astromaterials Acquisition and Curation Office (henceforth referred to herein as NASA Curation Office) at NASA Johnson Space Center (JSC) is responsible for curating all of NASA's extraterrestrial samples. Under the governing document, NASA Policy Directive (NPD) 7100.10E "Curation of Extraterrestrial Materials", JSC is charged with "...curation of all extra-terrestrial material under NASA control, including future NASA missions." The Directive goes on to define Curation as including "...documentation, preservation, preparation, and distribution of samples for research, education, and public outreach." Here we describe some of the past, present, and future activities of the NASA Curation Office.
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Duties to Extraterrestrial Microscopic Organisms
Cockell, C. S.
Formulating a normative axiology for the treatment of extraterrestrial microscopic organisms, should they ever be found, requires an extension of environmental ethics to beyond the Earth. Using an ethical framework for the treatment of terrestrial micro-organisms, this paper elaborates a similar ethic for the treatment of extraterrestrial microscopic organisms. An ethic of `teloempathy' allows for the moral considerability of any organism that has `interests', based on rudimentary qualities of conativism, and therefore allows for an identical treatment of all life, related or not related to life on Earth. Although, according to this ethic, individual extraterrestrial microscopic organisms have a good of their own and even `rights', at this level the ethic can only be theoretical, allowing for the inevitable destruction of many individual organisms during the course of human exploratory missions, similarly to the daily destruction of microbes by humans on Earth. A holistic teloempathy, an operative ethic, not only provides a framework for human exploration, but it also has important implications for planetary protection and proposals to implement planetary-scale atmospheric alterations on other bodies. Even prior to the discovery of extraterrestrial life, or the discovery of a complete absence of such life, this exercise yields important insights into the moral philosophy that guides our treatment of terrestrial micro-organisms.
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Curating NASA's Future Extraterrestrial Sample Collections: How Do We Achieve Maximum Proficiency?
McCubbin, Francis; Evans, Cynthia; Zeigler, Ryan; Allton, Judith; Fries, Marc; Righter, Kevin; Zolensky, Michael
2016-01-01
The Astromaterials Acquisition and Curation Office (henceforth referred to herein as NASA Curation Office) at NASA Johnson Space Center (JSC) is responsible for curating all of NASA's extraterrestrial samples. Under the governing document, NASA Policy Directive (NPD) 7100.10E "Curation of Extraterrestrial Materials", JSC is charged with "The curation of all extraterrestrial material under NASA control, including future NASA missions." The Directive goes on to define Curation as including "... documentation, preservation, preparation, and distribution of samples for research, education, and public outreach." Here we describe some of the ongoing efforts to ensure that the future activities of the NASA Curation Office are working towards a state of maximum proficiency.
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Science, religion, and the search for extraterrestrial intelligence
Wilkinson, David
2013-01-01
If the discovery of life elsewhere in the universe is just around the corner, what would be the consequences for religion? Would it represent another major conflict between science and religion, even leading to the death of faith? Some would suggest that the discovery of any suggestion of extraterrestrial life would have a greater impact than even the Copernican and Darwinian revolutions. It is now over 50 years since the first modern scientific papers were published on the search for extraterrestrial intelligence (SETI). Yet the religious implications of this search and possible discovery have never been systematically addressed in the scientific or theological arena. SETI is now entering its most important era of scientific development. New observation techniques are leading to the discovery of extra-solar planets daily, and the Kepler mission has already collected over 1000 planetary candidates. This deluge of data is transforming the scientific and popular view of the existence of extraterrestrial intel...
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Klein, M. J.
1993-01-01
Extraterrestrial Intelligence is intelligent life that developed somewhere other than the earth. Such life has not yet been discovered. However, scientific research, including astronomy, biology, planetary science and studies of fossils here on earth have led many scientists to conclude that such life may exist on planets orbiting at least some of the hundreds of billions of stars in our Milky Way Galaxy. Today, some researchers are trying to find evidence for extraterrestrial intelligence. This effort is often called SETI, which stands for Search for Extraterrestrial Intelligence. SETI researchers decided that looking for evidence of their technology might be the best way to discover other intelligent life in the Galaxy. They decided to use large radio telescopes to search the sky over a wide range of radio frequencies...
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Extraterrestrial Intelligence: What Would it Mean?
Impey, Chris
2015-04-01
Results from NASA's Kepler mission imply a hundred million Earth-like habitable worlds in the Milky Way galaxy, many of which formed billions of years before the Earth. Each of these worlds is likely to have all of the ingredients needed for biology. The real estate of time and space for the evolution of intelligent life is formidable, begging the question of whether or not we are alone in the universe. The implications of making contact have been explored extensively in science fiction and the popular culture, but less frequently in the serious scientific literature. Astronomers have carried out searches for extraterrestrial intelligence for over half a century, with no success so far. In practice, it is easier to search for alien technology than to discern intelligence of unknown function and form. In this talk, the modes of technology that can currently be detected are summarized, along with the implications of a timing argument than any detected civilization is likely to be much more advanced than ours. Fermi's famous question ``Where Are They?'' is as well posed now as it was sixty years ago. The existence of extraterrestrial intelligence would have profound practical, cultural, and religious implications for humanity.
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Thompson, R. L.; Ramler, J. R.; Stevenson, S. M.
1974-01-01
A feasibility study of extraterrestrial disposal of radioactive waste is reported. This report covers the initial work done on only one part of the NASA study, that evaluates and compares possible space destinations and space transportation systems. The currently planned space shuttle was found to be more cost effective than current expendable launch vehicles by about a factor of 2. The space shuttle requires a third stage to perform the waste disposal missions. Depending on the particular mission, this third stage could be either a reusable space tug or an expendable stage such as a Centaur.
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Race, Margaret S.; Randolph, Richard O.
While formal principles have been adopted for the eventuality of detecting intelligent life in our galaxy (SETI Principles), no such guidelines exist for the discovery of non-intelligent extraterrestrial life within the solar system. Current scientifically based planetary protection policies for solar system exploration address how to undertake exploration, but do not provide clear guidance on what to do if and when life is detected. Considering that martian life could be detected under several different robotic and human exploration scenarios in the coming decades, it is appropriate to anticipate how detection of non-intelligent, microbial life could impact future exploration missions and activities, especially on Mars. This paper discusses a proposed set of interim guidelines based loosely on the SETI Principles and addresses issues extending from the time of discovery through future handling and treatment of extraterrestrial life on Mars or elsewhere. Based on an analysis of both scientific and ethical considerations, there is a clear need for developing operating protocols applicable at the time of discovery and a decision making framework that anticipates future missions and activities, both robotic and human. There is growing scientific confidence that the discovery of extraterrestrial life in some form is nearly inevitable. If and when life is discovered beyond Earth, non-scientific dimensions may strongly influence decisions about the nature and scope of future missions and activities. It is appropriate to encourage international discussion and consideration of the issues prior to an event of such historical significance.
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Search for extraterrestrial intelligence (SETI)
International Nuclear Information System (INIS)
Morrison, P.; Billingham, J.; Wolfe, J.
1977-01-01
Findings are presented of a series of workshops on the existence of extraterrestrial intelligent life and ways in which extraterrestrial intelligence might be detected. The coverage includes the cosmic and cultural evolutions, search strategies, detection of other planetary systems, alternate methods of communication, and radio frequency interference. 17 references
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Extraterrestrial altruism evolution and ethics in the cosmos
2014-01-01
Extraterrestrial Altruism examines a basic assumption of the Search for Extraterrestrial Intelligence (SETI): that extraterrestrials will be transmitting messages to us for our benefit. This question of whether extraterrestrials will be altruistic has become increasingly important in recent years as SETI scientists have begun contemplating transmissions from Earth to make contact. Should we expect altruism to evolve throughout the cosmos, or is this only wishful thinking? Would this make biological sense? Is it dangerous to send messages to other worlds, as Stephen Hawking has suggested? Would extraterrestrial societies be based on different ethical principles? Extraterrestrial Altruism explores these and related questions about the motivations of civilizations beyond Earth, providing new insights that are critical for SETI. Chapters are authored by leading scholars from diverse disciplines—anthropology, astronomy, biology, chemistry, computer science, cosmology, engineering, history of science, law, philos...
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Universalist ethics in extraterrestrial encounter
Baum, Seth D.
2010-02-01
If humanity encounters an extraterrestrial civilization, or if two extraterrestrial civilizations encounter each other, then the outcome may depend not only on the civilizations' relative strength to destroy each other but also on what ethics are held by one or both civilizations. This paper explores outcomes of encounter scenarios in which one or both civilizations hold a universalist ethical framework. Several outcomes are possible in such scenarios, ranging from one civilization destroying the other to both civilizations racing to be the first to commit suicide. Thus, attention to the ethics of both humanity and extraterrestrials is warranted in human planning for such an encounter. Additionally, the possibility of such an encounter raises profound questions for contemporary human ethics, even if such an encounter never occurs.
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The Extraterrestrial Life Debate from Antiquity to 1900
Crowe, Michael J.; Dowd, Matthew F.
This chapter provides an overview of the Western historical debate regarding extraterrestrial life from antiquity to the beginning of the twentieth century. Though schools of thought in antiquity differed on whether extraterrestrial life existed, by the Middle Ages, the Aristotelian worldview of a unified, finite cosmos without extraterrestrials was most influential, though there were such dissenters as Nicholas of Cusa. That would change as the Copernican revolution progressed. Scholars such as Bruno, Kepler, Galileo, and Descartes would argue for a Copernican system of a moving Earth. Cartesian and Newtonian physics would eventually lead to a view of the universe in which the Earth was one of many planets in one of many solar systems extended in space. As this cosmological model was developing, so too were notions of extraterrestrial life. Popular and scientific writings, such as those by Fontenelle and Huygens, led to a reversal of fortunes for extraterrestrials, who by the end of the century were gaining recognition. From 1700 to 1800, many leading thinkers discussed extraterrestrial intelligent beings. In doing so, they relied heavily on arguments from analogy and such broad principles and ideas as the Copernican Principle, the Principle of Plenitude, and the Great Chain of Being. Physical evidence for the existence of extraterrestrials was minimal, and was always indirect, such as the sighting of polar caps on Mars, suggesting similarities between Earth and other places in the universe. Nonetheless, the eighteenth century saw writers from a wide variety of genres—science, philosophy, theology, literature—speculate widely on extraterrestrials. In the latter half of the century, increasing research in stellar astronomy would be carried out, heavily overlapping with an interest in extraterrestrial life. By the end of the eighteenth century, belief in intelligent beings on solar system planets was nearly universal and certainly more common than it would be by
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Planetary protection considerations for sample-return missions
Rummel, J.
The analysis on Earth of materials returned from other solar system bodies, and beyond, is likely one of the most effective ways for us to learn about the origins, history, and present state of the universe outside of our home planet. In the past, the Apollo missions were able to return large quantities of material from the Moon, while missions currently flying (Genesis and Stardust) intend to return much smaller quantities of material. Planned and conceptualized future missions (cf., MUSES-C) intend to return a wide variety of samples such as those from a near-Earth asteroid, the surface and atmosphere of Mars , and perhaps once more from the Earth's Moon. In some cases, the bodies targeted for sample return missions may have the capability of harboring indigenous life, while in other cases there is scant possibility of that. Considerations in determining the potential for extraterrestrial contamination from sample return missions have been studied, and include such factors as the availability of liquid water in or on the target body, the availability of m tabolicallye useful energy sources, the likelihood that organic matter was available, and the overall temperature and radiation history of the sampled areas. Also of note is the potential that the natural influx to Earth of that materials in question (e.g., meteorites, etc.) might overwhelm the ability of a targeted sample-return mission to contribute something novel to the Earth's environment. Missions thought to pose a risk of extraterrestrial biological contamination are subject to a containment provision that may be very difficult to implement on a single, moderate-cost mission, but such steps are necessary to protect both our own planet and the health of solar-system exploration missions and the science they can do.
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Curating NASA's future extraterrestrial sample collections: How do we achieve maximum proficiency?
McCubbin, Francis; Evans, Cynthia; Allton, Judith; Fries, Marc; Righter, Kevin; Zolensky, Michael; Zeigler, Ryan
2016-07-01
Introduction: The Astromaterials Acquisition and Curation Office (henceforth referred to herein as NASA Curation Office) at NASA Johnson Space Center (JSC) is responsible for curating all of NASA's extraterrestrial samples. Under the governing document, NASA Policy Directive (NPD) 7100.10E "Curation of Extraterrestrial Materials", JSC is charged with "The curation of all extraterrestrial material under NASA control, including future NASA missions." The Directive goes on to define Curation as including "…documentation, preservation, preparation, and distribution of samples for research, education, and public outreach." Here we describe some of the ongoing efforts to ensure that the future activities of the NASA Curation Office are working to-wards a state of maximum proficiency. Founding Principle: Curatorial activities began at JSC (Manned Spacecraft Center before 1973) as soon as design and construction planning for the Lunar Receiving Laboratory (LRL) began in 1964 [1], not with the return of the Apollo samples in 1969, nor with the completion of the LRL in 1967. This practice has since proven that curation begins as soon as a sample return mission is conceived, and this founding principle continues to return dividends today [e.g., 2]. The Next Decade: Part of the curation process is planning for the future, and we refer to these planning efforts as "advanced curation" [3]. Advanced Curation is tasked with developing procedures, technology, and data sets necessary for curating new types of collections as envisioned by NASA exploration goals. We are (and have been) planning for future curation, including cold curation, extended curation of ices and volatiles, curation of samples with special chemical considerations such as perchlorate-rich samples, curation of organically- and biologically-sensitive samples, and the use of minimally invasive analytical techniques (e.g., micro-CT, [4]) to characterize samples. These efforts will be useful for Mars Sample Return
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How likely is extraterrestrial life?
Halley, J Woods
2012-01-01
What does existing scientific knowledge about physics, chemistry, meteorology and biology tell us about the likelihood of extraterrestrial life and civilizations? And what does the fact that there is currently no credible scientific evidence for the existence of extraterrestrial biospheres or civilizations teach us? This book reviews the various scientific issues that arise in considering the question of how common extraterrestrial life is likely to be in our galaxy and whether humans are likely to detect it. The book stands out because of its very systematic organization and relatively unbiased treatment of the main open question. It covers all relevant aspects of many disciplines required to present the different possible answers. It has and will provide undergraduates with a stimulating introduction to many of these fields at an early stage in their university careers, when they are still choosing a specialty. The difficulties and the range of possible answers to the title question are carefully addr...
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FINDING EXTRATERRESTRIAL LIFE USING GROUND-BASED HIGH-DISPERSION SPECTROSCOPY
International Nuclear Information System (INIS)
Snellen, I. A. G.; Le Poole, R.; Brogi, M.; Birkby, J.; De Kok, R. J.
2013-01-01
Exoplanet observations promise one day to unveil the presence of extraterrestrial life. Atmospheric compounds in strong chemical disequilibrium would point to large-scale biological activity just as oxygen and methane do in the Earth's atmosphere. The cancellation of both the Terrestrial Planet Finder and Darwin missions means that it is unlikely that a dedicated space telescope to search for biomarker gases in exoplanet atmospheres will be launched within the next 25 years. Here we show that ground-based telescopes provide a strong alternative for finding biomarkers in exoplanet atmospheres through transit observations. Recent results on hot Jupiters show the enormous potential of high-dispersion spectroscopy to separate the extraterrestrial and telluric signals, making use of the Doppler shift of the planet. The transmission signal of oxygen from an Earth-twin orbiting a small red dwarf star is only a factor of three smaller than that of carbon monoxide recently detected in the hot Jupiter τ Boötis b, albeit such a star will be orders of magnitude fainter. We show that if Earth-like planets are common, the planned extremely large telescopes can detect oxygen within a few dozen transits. Ultimately, large arrays of dedicated flux-collector telescopes equipped with high-dispersion spectrographs can provide the large collecting area needed to perform a statistical study of life-bearing planets in the solar neighborhood.
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Planetary Protection Knowledge Gaps for Human Extraterrestrial Missions Workshop Booklet - 2015
Fonda, Mark L.
2015-01-01
Although NASA's preparations for the Apollo lunar missions had only a limited time to consider issues associated with the protection of the Moon from biological contamination and the quarantine of the astronauts returning to Earth, they learned many valuable lessons (both positive and negative) in the process. As such, those efforts represent the baseline of planetary protection preparations for sending humans to Mars. Neither the post-Apollo experience or the Shuttle and other follow-on missions of either the US or Russian human spaceflight programs could add many additional insights to that baseline. Current mission designers have had the intervening four decades for their consideration, and in that time there has been much learned about human-associated microbes, about Mars, and about humans in space that has helped prepare us for a broad spectrum of considerations regarding potential biological contamination in human Mars missions and how to control it. This paper will review the approaches used in getting this far, and highlight some implications of this history for the future development of planetary protection provisions for human missions to Mars. The role of NASA and ESA's planetary protection offices, and the aegis of COSPAR have been particularly important in the ongoing process.
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Zimmerman, A. V.; Thompson, R. L.; Lubick, R. J.
1973-01-01
A feasibility study is summarized of extraterrestrial (space) disposal of radioactive waste. The initial work on the evaluation and comparison of possible space destinations and launch vehicles is reported. Only current or planned space transportation systems were considered. The currently planned space shuttle was found to be more cost effective than current expendable launch vehicles, by about a factor of two. The space shuttle will require a third stage to perform the disposal missions. Depending on the particular mission this could be either a reusable space tug or an expendable stage such as a Centaur. Of the destinations considered, high earth orbits (between geostationary and lunar orbit altitudes), solar orbits (such as a 0.90 AU circular solar orbit) or a direct injection to solar system escape appear to be the best candidates. Both earth orbits and solar orbits have uncertainties regarding orbit stability and waste package integrity for times on the order of a million years.
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International Nuclear Information System (INIS)
Ashe, T.L.; Baggenstoss, W.G.; Bons, R.
1990-01-01
Extra-terrestrial exploration and development missions of the next century will require reliable, low-mass power generation modules of 100 kW e and more. These modules will be required to support both fixed-base and manned rover/explorer power needs. Low insolation levels at and beyond Mars and long periods of darkness on the moon make solar conversion less desirable for surface missions. For these missions, a closed Brayton cycle energy conversion system coupled with a reactor heat source is a very attractive approach. The authors conducted parametric studies to assess optimized system design trends for nuclear-Brayton systems as a function of operating environment and user requirements. The inherent design flexibility of the closed Brayton cycle energy conversion system permits ready adaptation of the system to future design constraints. This paper describes a dramatic contrast between system designs requiring man-rated shielding. The paper also considers the ramification of using indigenous materials to provide reactor shielding for a fixed-base power source
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Extraterrestrial Metals Processing, Phase I
National Aeronautics and Space Administration — The Extraterrestrial Metals Processing (EMP) system produces ferrosilicon, silicon monoxide, a glassy mixed oxide slag, and smaller amounts of alkali earth...
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Extraterrestrial Metals Processing, Phase II
National Aeronautics and Space Administration — The Extraterrestrial Metals Processing (EMP) system produces iron, silicon, and light metals from Mars, Moon, or asteroid resources in support of advanced human...
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Mitigating Adverse Effects of a Human Mission on Possible Martian Indigenous Ecosystems
Lupisella, M. L.
2000-07-01
Although human beings are, by most standards, the most capable agents to search for and detect extraterrestrial life, we are also potentially the most harmful. While there has been substantial work regarding forward contamination with respect to robotic missions, the issue of potential adverse effects on possible indigenous Martian ecosystems, such as biological contamination, due to a human mission has remained relatively unexplored and may require our attention now as this presentation will try to demonstrate by exploring some of the relevant scientific questions, mission planning challenges, and policy issues. An informal, high-level mission planning decision tree will be discussed and is included as the next page of this abstract. Some of the questions to be considered are: (1) To what extent could contamination due to a human presence compromise possible indigenous life forms? (2) To what extent can we control contamination? For example, will it be local or global? (3) What are the criteria for assessing the biological status of Mars, both regionally and globally? For example, can we adequately extrapolate from a few strategic missions such as sample return missions? (4) What should our policies be regarding our mission planning and possible interaction with what are likely to be microbial forms of extraterrestrial life? (5) Central to the science and mission planning issues is the role and applicability of terrestrial analogs, such as Lake Vostok for assessing drilling issues, and modeling techniques. Central to many of the policy aspects are scientific value, international law, public concern, and ethics. Exploring this overall issue responsibly requires an examination of all these aspects and how they interrelate. A chart is included, titled 'Mission Planning Decision Tree for Mitigating Adverse Effects to Possible Indigenous Martian Ecosystems due to a Human Mission'. It outlines what questions scientists should ask and answer before sending humans to Mars.
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The Ethical Implications for Discovery of Extraterrestrial Life
Stuart, Jill
2012-05-01
Ethical frameworks seek to normatively structure our behaviour and preconstitute expectations with regards to moral activity towards each other as well as other creatures and even non-sentient objects such as the environment. This paper considers how ongoing ethical discussions relating to earth-based interactions can be used as analogies to inform nascent conversations about potential future encounters with extraterrestrial life—while also highlighting where these geocentric conversations may fail to capture the unique dynamics of potential extraterrestrial encounters. The paper specifically considers the spectrum of ethical frameworks currently used in earth-based interactions and how they might apply outside the geocentric referent; from ethics towards non- sentient life on earth such as plants and the environment; to ethics towards sentient but ‘unintelligent' life; to intelligent life nonetheless deemed less intelligent than humans. Next the paper considers interactions that we have yet to (knowingly) have encountered here on earth: the ethics of interactions with life more intelligent than ourselves; and finally the ethics of interaction with robotic ‘post-biological' forms, which some specialists in extraterrestrial communications have speculated will likely be the form of ‘creatures' to be encountered should contact with extraterrestrials ever be made. Finally the paper will address deeper philosophical-ethical questions about the significance of such an exercise in shifting ethical frameworks from an anthropocentric perspective.
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Implications of extraterrestrial material on the origin of life
Pasek, Matthew A.
Meteoritic organic material may provide the best perspective on prebiotic chemistry. Meteorites have also been invoked as a source of prebiotic material. This study suggests a caveat to extraterrestrial organic delivery: that prebiotic meteoritic organics were too dilute to promote prebiotic reactions. However, meteoritic material provides building material for endogenous synthesis of prebiotic molecules, such as by hydrolysis of extraterrestrial organic tars, and corrosion of phosphide minerals.
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The Search for Extraterrestrial Intelligence (SETI)
Tarter, Jill
The search for evidence of extraterrestrial intelligence is placed in the broader astronomical context of the search for extrasolar planets and biomarkers of primitive life elsewhere in the universe. A decision tree of possible search strategies is presented as well as a brief history of the search for extraterrestrial intelligence (SETI) projects since 1960. The characteristics of 14 SETI projects currently operating on telescopes are discussed and compared using one of many possible figures of merit. Plans for SETI searches in the immediate and more distant future are outlined. Plans for success, the significance of null results, and some opinions on deliberate transmission of signals (as well as listening) are also included. SETI results to date are negative, but in reality, not much searching has yet been done.
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Hoover, Richard B.; Kolb, Vera M.
2009-01-01
The early search for the amino acids on the lunar surface fines indicated such a low amount of the amino acids that it was deemed insignifi cant. While the later studies seemed to depart in some ways from the earlier results, they were not pursued. In this paper we critically ev aluate the results from the Apollo missions from the new perspective with considerations of the sensitivity of the instrumentation availabl e at the time. We discuss the possible relevance of the lunar results to the findings of the amino acids on the surfaces of other extraterrestrial bodies, such as Mars.
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Funding the Search for Extraterrestrial Intelligence with a Lottery Bond
Haqq-Misra, Jacob
2013-01-01
I propose the establishment of a SETI Lottery Bond to provide a continued source of funding for the search for extraterrestrial intelligence (SETI). The SETI Lottery Bond is a fixed rate perpetual bond with a lottery at maturity, where maturity occurs only upon discovery and confirmation of extraterrestrial intelligent life. Investors in the SETI Lottery Bond purchase shares that yield a fixed rate of interest that continues indefinitely until SETI succeeds---at which point a random subset of...
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Cheng, L.K.; Dijkhuizen, N.; Nieuwland, R.; Faber, A.J.; Gielesen, W.L.M.; Lucas, J.; Boussard-Plédel, C.; Houizot, P.; Pereira Do Carmo, J.
2009-01-01
Various space telescope array systems are being considered to investigate other terrestrial planets orbiting around nearby stars in order to find extra-terrestrial life. One of them is the DARWIN mission of the European Space Agency (ESA). The required technology is the nulling interferometer. The
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Extra-terrestrial construction processes - Advancements, opportunities and challenges
Lim, Sungwoo; Prabhu, Vibha Levin; Anand, Mahesh; Taylor, Lawrence A.
2017-10-01
Government space agencies, including NASA and ESA, are conducting preliminary studies on building alternative space-habitat systems for deep-space exploration. Such studies include development of advanced technologies for planetary surface exploration, including an in-depth understanding of the use of local resources. Currently, NASA plans to land humans on Mars in the 2030s. Similarly, other space agencies from Europe (ESA), Canada (CSA), Russia (Roscosmos), India (ISRO), Japan (JAXA) and China (CNSA) have already initiated or announced their plans for launching a series of lunar missions over the next decade, ranging from orbiters, landers and rovers for extended stays on the lunar surface. As the Space Odyssey is one of humanity's oldest dreams, there has been a series of research works for establishing temporary or permanent settlement on other planetary bodies, including the Moon and Mars. This paper reviews current projects developing extra-terrestrial construction, broadly categorised as: (i) ISRU-based construction materials; (ii) fabrication methods; and (iii) construction processes. It also discusses four categories of challenges to developing an appropriate construction process: (i) lunar simulants; (ii) material fabrication and curing; (iii) microwave-sintering based fabrication; and (iv) fully autonomous and scaled-up construction processes.
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Tong, Vincent C H
2015-01-01
Seismology is a highly effective tool for investigating the internal structure of the Earth. Similar techniques have also successfully been used to study other planetary bodies (planetary seismology), the Sun (helioseismology), and other stars (asteroseismology). Despite obvious differences between stars and planetary bodies, these disciplines share many similarities and together form a coherent field of scientific research. This unique book takes a transdisciplinary approach to seismology and seismic imaging, reviewing the most recent developments in these extraterrestrial contexts. With contributions from leading scientists, this timely volume systematically outlines the techniques used in observation, data processing, and modelling for asteroseismology, helioseismology, and planetary seismology, drawing comparisons with seismic methods used in geophysics. Important recent discoveries in each discipline are presented. With an emphasis on transcending the traditional boundaries of astronomy, solar, planetary...
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Comparison of the Raman spectra of ion irradiated soot and collected extraterrestrial carbon
Brunetto, R.; Pino, T.; Dartois, E.; Cao, A.-T.; d'Hendecourt, L.; Strazzulla, G.; Bréchignac, Ph.
2009-03-01
We use a low pressure flame to produce soot by-products as possible analogues of the carbonaceous dust present in diverse astrophysical environments, such as circumstellar shells, diffuse interstellar medium, planetary disks, as well as in our own Solar System. Several soot samples, displaying an initial chemical diversity from aromatic to aliphatic dominated material, are irradiated with 200-400 keV H +, He +, and Ar ++ ions, with fluences comprised between 10 14 and 10 16 ions/cm 2, to simulate expected radiation induced modification on extraterrestrial carbon. The evolution of the samples is monitored using Raman spectroscopy, before, during, and after irradiation. A detailed analysis of the first- and second-order Raman spectra is performed, using a fitting combination of Lorentzian and/or Gaussian-shaped bands. Upon irradiation, the samples evolve toward an amorphous carbon phase. The results suggest that the observed variations are more related to vacancy formation than ionization processes. A comparison with Raman spectra of extraterrestrial organic matter and other irradiation experiments of astrophysically relevant carbonaceous materials is presented. The results are consistent with previous experiments showing mostly amorphization of various carbonaceous materials. Irradiated soots have Raman spectra similar to those of some meteorites, IDPs, and Comet Wild 2 grains collected by the Stardust mission. Since the early-Sun expected irradiation fluxes sufficient for amorphization are compatible with accretion timescales, our results support the idea that insoluble organic matter (IOM) observed in primitive meteorites has experienced irradiation-induced amorphization prior to the accretion of the parent bodies, emphasizing the important role played by early solar nebula processing.
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Psycholinguistics and the Search for Extraterrestrial Intelligence
Directory of Open Access Journals (Sweden)
Lidija Krotenko
2017-09-01
Full Text Available The author of the article reveals the possibilities of psycholinguistics in the identifi cation and interpretation of languages and texts of Alien Civilizations. The author combines modern interdisciplinary research in psycholinguistics with the theory “Evolving Matter” proposed by Oleg Bazaluk and concludes that the identifi cation of languages and texts of Alien Civilizations, as well as the communication of terrestrial civilization with Extraterrestrial Intelligence, is in principle possible. To that end, it is necessary to achieve the required level of the modeling of neurophilosophy and to include these achievements of modern psycholinguistics studies: а language acquisition; b language comprehension; c language production; d second language acquisition. On the one hand, the possibilities of neurophilosophy to accumulate and model advanced neuroscience research; on the other hand, highly specialized psycholinguistic studies in language evolution are able to provide the communication of terrestrial civilization with Extraterrestrial Intelligence.
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Anthropomorphism in the search for extra-terrestrial intelligence - The limits of cognition?
Bohlmann, Ulrike M.; Bürger, Moritz J. F.
2018-02-01
The question "Are we alone?" lingers in the human mind since ancient times. Early human civilisations populated the heavens above with a multitude of Gods endowed with some all too human characteristics - from their outer appearance to their innermost motivations. En passant they created thereby their own cultural founding myths on which they built their understanding of the world and its phenomena and deduced as well rules for the functioning of their own society. Advancing technology has enabled us to conduct this human quest for knowledge with more scientific means: optical and radio-wavelengths are being monitored for messages by an extra-terrestrial intelligence and active messaging attempts have also been undertaken. Scenarios have been developed for a possible detection of extra-terrestrial intelligence and post-detection guidelines and protocols have been elaborated. The human responses to the whole array of questions concerning the potential existence, discovery of and communication/interaction with an extra-terrestrial intelligence share as one clear thread a profound anthropomorphism, which ascribes classical human behavioural patterns also to an extra-terrestrial intelligence in much the same way as our ancestors attributed comparable conducts to mythological figures. This paper aims at pinpointing this thread in a number of classical reactions to basic questions related to the search for extra-terrestrial intelligence. Many of these reactions are based on human motives such as curiosity and fear, rationalised by experience and historical analogy and modelled in the Science Fiction Culture by literature and movies. Scrutinising the classical hypothetical explanations of the Fermi paradox under the angle of a potentially undue anthropomorphism, this paper intends to assist in understanding our human epistemological limitations in the search for extra-terrestrial intelligence. This attempt is structured into a series of questions: I. Can we be alone? II
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The Problem of Extraterrestrial Civilizations and Extrasolar Planets
Mickaelian, A. M.
2015-07-01
The problem of extraterrestrial intelligence is the best example of multidisciplinary science. Here philosophy and religion, astronomy, radiophysics, spectrography, space flights and astronautics, geology and planetology, astroecology, chemistry and biology, history and archaeology, psychology, sociology, linguistics, diplomacy, UFOs and peculiar phenomena are involved. Among these many-sided studies, astronomers have probably displayed the most progress by discovering thousands of extrasolar planets. At present, a number of search programs are being accomplished, including those with space telescopes, and planets in so-called "habitable zone" are considered as most important ones, for which various orbital and physical parameters are being calculated. As the discovery of extraterrestrial life is the final goal, a special attention is given to Earth-like planets, for the discovery of which most sensitive technical means are necessary.
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L factor: hope and fear in the search for extraterrestrial intelligence
Rubin, Charles T.
2001-08-01
The L factor in the Drake equation is widely understood to account for most of the variance in estimates of the number of extraterrestrial intelligences that might be contacted by the search for extraterrestrial intelligence (SETI). It is also among the hardest to quantify. An examination of discussions of the L factor in the popular and technical SETI literature suggests that attempts to estimate L involve a variety of potentially conflicting assumptions about civilizational lifespan that reflect hopes and fears about the human future.
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Information theory, animal communication, and the search for extraterrestrial intelligence
Doyle, Laurance R.; McCowan, Brenda; Johnston, Simon; Hanser, Sean F.
2011-02-01
We present ongoing research in the application of information theory to animal communication systems with the goal of developing additional detectors and estimators for possible extraterrestrial intelligent signals. Regardless of the species, for intelligence (i.e., complex knowledge) to be transmitted certain rules of information theory must still be obeyed. We demonstrate some preliminary results of applying information theory to socially complex marine mammal species (bottlenose dolphins and humpback whales) as well as arboreal squirrel monkeys, because they almost exclusively rely on vocal signals for their communications, producing signals which can be readily characterized by signal analysis. Metrics such as Zipf's Law and higher-order information-entropic structure are emerging as indicators of the communicative complexity characteristic of an "intelligent message" content within these animals' signals, perhaps not surprising given these species' social complexity. In addition to human languages, for comparison we also apply these metrics to pulsar signals—perhaps (arguably) the most "organized" of stellar systems—as an example of astrophysical systems that would have to be distinguished from an extraterrestrial intelligence message by such information theoretic filters. We also look at a message transmitted from Earth (Arecibo Observatory) that contains a lot of meaning but little information in the mathematical sense we define it here. We conclude that the study of non-human communication systems on our own planet can make a valuable contribution to the detection of extraterrestrial intelligence by providing quantitative general measures of communicative complexity. Studying the complex communication systems of other intelligent species on our own planet may also be one of the best ways to deprovincialize our thinking about extraterrestrial communication systems in general.
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SETI pioneers scientists talk about their search for extraterrestrial intelligence
Swift, David W.
1990-01-01
Why did some scientists decide to conduct a search for extraterrestrial intelligence (SETI)? What factors in their personal development predisposed them to such a quest? What obstacles did they encounter along the way? David Swift interviewed the first scientists involved in the search & offers a fascinating overview of the emergence of this modern scientific endeavor. He allows some of the most imaginative scientific thinkers of our time to hold forth on their views regarding SETI & extraterrestrial life & on how the field has developed. Readers will react with a range of opinions as broad as those concerning the likelihood of success in SETI itself. ''A goldmine of original information.''
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De la Torre, Gabriel G.
2014-02-01
This study presents a new approach to the concept of cosmic consciousness integrated in current neuroscience knowledge and discusses implications for the search for extraterrestrial intelligence. It also examines different aspects related to consciousness and how it may play a key role in the understanding of the search for extraterrestrial intelligence and life in the Universe and its implications. Subjects (n=116) were college students from Spain, the United States, and Italy. Subjects responded to a questionnaire comprising five different sections: (A) religious beliefs, (B) environment and general opinion, (C) astronomy, (D) contact, and (E) attention and perception. The results showed the importance of several modular aspects that affect Space awareness in humans. Preliminary results are discussed with regard to current neuroscience, factor analysis, and possible implications for the understanding of contact with extraterrestrial intelligence. The roles of education, new search strategies, and possible contact scenarios are also discussed.
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Atmosphere composition monitor for space station and advanced missions application
International Nuclear Information System (INIS)
Wynveen, R.A.; Powell, F.T.
1987-01-01
Long-term human occupation of extraterrestrial locations may soon become a reality. The National Aeronautics and Space Administration (NASA) has recently completed the definition and preliminary design of the low earth orbit (LEO) space station. They are now currently moving into the detailed design and fabrication phase of this space station and are also beginning to analyze the requirements of several future missions that have been identified. These missions include, for example, Lunar and Mars sorties, outposts, bases, and settlements. A requirement of both the LEO space station and future missions are environmental control and life support systems (ECLSS), which provide a comfortable environment for humans to live and work. The ECLSS consists of several major systems, including atmosphere revitalization system (ARS), atmosphere pressure and composition control system, temperature and humidity control system, water reclamation system, and waste management system. Each of these major systems is broken down into subsystems, assemblies, units, and instruments. Many requirements and design drivers are different for the ECLSS of the LEO space station and the identified advanced missions (e.g., longer mission duration). This paper discusses one of the ARS assemblies, the atmosphere composition monitor assembly (ACMA), being developed for the LEO space station and addresses differences that will exist for the ACMA of future missions
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Who owns the Moon? extraterrestrial aspects of land and mineral resources ownership
Pop, Virgiliu
2008-01-01
This work investigates the permissibility and viability of property rights on the celestial bodies, particularly the extraterrestrial aspects of land and mineral resources ownership. In lay terms, it aims to find an answer to the question "Who owns the Moon?" After critically analyzing and dismantling with legal arguments the trivial issue of sale of extraterrestrial real estate, the book addresses the apparent silence of the law in the field of landed property in outer space, scrutinizing whether the factual situation on the extraterrestrial realms calls for legal regulations. The legal status of asteroids and the relationship between appropriation under international law and civil law appropriation are duly examined, as well as different property patterns – such as the commons regime, the Common Heritage of the Mankind, and the Frontier paradigm. Virgiliu Pop is one of world's specialists in the area of space property rights. A member of the International Institute of Space Law, Virgiliu has authored seve...
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Tracers of the Extraterrestrial Component in Sediments and Inferences for Earth's Accretion History
Kyte, Frank T.
2003-01-01
The study of extraterrestrial matter in sediments began with the discovery of cosmic spherules during the HMS Challenger Expedition (1873-1876), but has evolved into a multidisciplinary study of the chemical, physical, and isotopic study of sediments. Extraterrestrial matter in sediments comes mainly from dust and large impactors from the asteroid belt and comets. What we know of the nature of these source materials comes from the study of stratospheric dust particles, cosmic spherules, micrometeorites, meteorites, and astronomical observations. The most common chemical tracers of extraterrestrial matter in sediments are the siderophile elements, most commonly iridium and other platinum group elements. Physical tracers include cosmic and impact spherules, Ni-rich spinels, meteorites, fossil meteorites, and ocean-impact melt debris. Three types of isotopic systems have been used to trace extraterrestrial matter. Osmium isotopes cannot distinguish chondritic from mantle sources, but provide a useful tool in modeling long-term accretion rates. Helium isotopes can be used to trace the long-term flux of the fine fraction of the interplanetary dust complex. Chromium isotopes can provide unequivocal evidence of an extraterrestrial source for sediments with high concentrations of meteoritic Cr. The terrestrial history of impacts, as recorded in sediments, is still poorly understood. Helium isotopes, multiple Ir anomalies, spherule beds, and craters all indicate a comet shower in the late Eocene. The Cretaceous-Tertiary boundary impact event appears to have been caused by a single carbonaceous chondrite projectile, most likely of asteroid origin. Little is known of the impact record in sediments from the rest of the Phanerozoic. Several impact deposits are known in the Precambrian, including several possible mega-impacts in the Early Archean.
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The weak force and SETH: The search for Extra-Terrestrial Homochirality
MacDermott, Alexandra J.
1996-07-01
We propose that a search for extra-terrestrial life can be approached as a Search for Extra-Terrestrial Homochirality-SETH. Homochirality is probably a pre-condition for life, so a chiral influence may be required to get life started. We explain how the weak force mediated by the Z0 boson gives rise to a small parity-violating energy difference (PVED) between enantiomers, and discuss how the resulting small excess of the more stable enantiomer may be amplified to homochirality. Titan and comets are good places to test for emerging pre-biotic homochirality, while on Mars there may be traces of homochirality as a relic of extinct life. Our calculations of the PVED show that the natural L-amino acids are indeed more stable than their enantiomers, as are several key D-sugars and right-hand helical DNA. Thiosubstituted DNA analogues show particularly large PVEDs. L-quartz is also more stable than D-quartz, and we believe that further crystal counts should be carried out to establish whether reported excesses of L quartz are real. Finding extra-terrestrial molecules of the same hand as on Earth would lend support to the universal chiral influence of the weak force. We describe a novel miniaturized space polarimeter, called the SETH Cigar, which we hope to use to detect optical rotation on other planets. Moving parts are avoided by replacing the normal rotating polarizer by multiple fixed polarizers at different angles as in the eye of the bee. Even if we do not find the same hand as on Earth, finding extra-terrestrial optical rotation would be of enormous importance as it would still be the homochiral signature of life.
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Extraterrestrial Organic Chemistry: From the Interstellar Medium to the Origins of Life
Pohorille, Andrew; DeVincenzi, Donald L. (Technical Monitor)
2000-01-01
Extraterrestrially delivered organics in the origin of cellular life. Various processes leading to the emergence of cellular life from organics delivered from space to earth or other planetary bodies in the solar system will be reviewed. The focus will be on: (1) self-assembly of amphiphilic material to vesicles and other structures, such as micelles and multilayers, and its role in creating environments suitable for chemical catalysis, (2) a possible role of extraterrestrial delivery of organics in the formation of the simplest bioenergetics (3) mechanisms leading from amino acids or their precursors to simple peptides and, subsequently, to the evolution of metabolism. These issues will be discussed from two opposite points of view: (1) Which molecules could have been particularly useful in the protobiological evolution; this may provide focus for searching for these molecules in interstellar media. (2) Assuming that a considerable part of the inventory of organic matter on the early earth was delivered extraterrestrially, what does relative abundance of different organics in space tell us about the scenario leading to the origin of life.
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[An encounter with extraterrestrial intelligence].
Hisabayashi, Hisashi
2003-12-01
It is much easier to find extraterrestrial intelligence than to detect simple organisms living on other planets. However, it is hard to communicate with such intelligence without the mutual understanding of inter-stellar communication protocol. The radio SETI (The Search for Extra-Terrestrial Intelligence) was initiated with the pioneering work of F. Drake in 1960, one year after the historical SETI paper by Cocconi and Morrison. This talk explains that SETI evolves with two bases of science; the understanding of our universe and the development of technology. Since SETI has had strong connection with radio astronomy from its early beginning, the impacts of radio astronomical findings and technological breakthrough can be seen in many aspects of the SETI history. Topics of this talk include the detection of microwave 3 K background radiation in the universe. Interstellar atomic and molecular lines found in radio-wave spectra provide the evidence of pre-biotic chemical evolution in such region. Radio telescope imaging and spectral technique are closely associated with methodology of SETI. Topics of the talk extend to new Allen Telescope Array and projected Square Kilometer Array. Recent optical SETI and the discoveries of extra solar planets are also explained. In the end, the recent understanding of our universe is briefly introduced in terms of matter, dark matter and dark energy. Even our understanding of the universe has been evolutionarily revolved and accumulated after 1960, we must recognize that our universe is still poorly understood and that astronomy and SETI are required to proceed hand in hand.
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Extraterrestrial Radiation Chemistry and Molecular Astronomy
Hudson, Reggie L.; Moore, Marla H.
2009-01-01
Astronomical observations of both solar system and interstellar regions have revealed a rich chemical inventory that includes most classes of organic molecules and selected inorganics. For example, gas-phase ethylene glycol and SOz have been observed by astronomers, while solidphase detections include OCS, H2O2 , and the cyanate anion.' All of these are found in environments that are, by earthly standards, exceedingly hostile: temperatures of 10 - 100 K, miniscule densities, and near-ubiquitous ionizing-radiation fields. Beyond the simplest chemical species, these conditions have made it difficult-to-impassible to account for the observed molecular abundances using gas-phase chemistry, suggesting solid-phase reactions play an important role. In extraterrestrial environments, cosmic rays, UV photons, and magnetospheric radiation all drive chemical reactions, even at cryogenic temperatures. To study this chemistry, radiation astrochemists conduct experiments on icy materials, frozen under vacuum and exposed to sources such as keV electrons and MeV protons. Compositional changes usually are followed with IR spectroscopy and, in selected cases, more-sensitive mass-spectral techniques. This talk will review some recent results on known and suspected extraterrestrial molecules and ions. Spectra and reaction pathways will be presented, and predictions made for interstellar chemistry and the chemistry of selected solar system objects. Some past radiation-chemical contributions, and future needs, will be explored.
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[Extraterrestrial influences on health and disease].
Sitar, J
1994-02-14
As to extraterrestrial influences on man in health and disease so far only the effect of the sun and moon are known. This concerns the effect of solar radiation of different wavelengths and the effect of corpuscular solar radiation which has an impact on the condition of the terrestrial magnetic field and electric conditions in the atmosphere. Moreover there is also a question of important influences of gravitation (tides). Here the influence of the position of the moon in relation to the connecting line between sun and earth is involved. In the course of the synodic month (from new moon to the next new moon) a semilunar periodicity of different medical and geomagnetic indicators as well as meteorological ones plays a part. Based on his own research and that of others the author reaches the conclusion that extraterrestrial and terrestrial influences are interrelated and exert a mutual influence on each other and that it is not sensible to separate them strictly. Investigation of all the mentioned influences is important not only for biomedical prognosis but also for basic geophysical and meteorological research. Perspectively it would be useful to plan model experiments. The author feels it is his duty to refuse publication of different horoscopes in the mass media, whatever the intention. In the lay public this may lead to popularization of astrology which has nothing in common with serious research.
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Finding Extraterrestrial Life Using Ground-based High-dispersion Spectroscopy
Snellen, I.A.G.; Kok, R.; Poole, le R.S.; Brogi, M.; Birkby, J.L.
2013-01-01
Exoplanet observations promise one day to unveil the presence of extraterrestrial life. Atmospheric compounds in strong chemical disequilibrium would point to large-scale biological activity just as oxygen and methane do in the Earth's atmosphere. The cancellation of both the Terrestrial Planet
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The weak force and SETH: The search for Extra-Terrestrial Homochirality
International Nuclear Information System (INIS)
MacDermott, A.J.
1996-01-01
We propose that a search for extra-terrestrial life can be approached as a Search for Extra-Terrestrial Homochirality emdash SETH. Homochirality is probably a pre-condition for life, so a chiral influence may be required to get life started. We explain how the weak force mediated by the Z 0 boson gives rise to a small parity-violating energy difference (PVED) between enantiomers, and discuss how the resulting small excess of the more stable enantiomer may be amplified to homochirality. Titan and comets are good places to test for emerging pre-biotic homochirality, while on Mars there may be traces of homochirality as a relic of extinct life. Our calculations of the PVED show that the natural L-amino acids are indeed more stable than their enantiomers, as are several key D-sugars and right-hand helical DNA. Thiosubstituted DNA analogues show particularly large PVEDs. L-quartz is also more stable than D-quartz, and we believe that further crystal counts should be carried out to establish whether reported excesses of L quartz are real. Finding extra-terrestrial molecules of the same hand as on Earth would lend support to the universal chiral influence of the weak force. We describe a novel miniaturized space polarimeter, called the SETH Cigar, which we hope to use to detect optical rotation on other planets. Moving parts are avoided by replacing the normal rotating polarizer by multiple fixed polarizers at different angles as in the eye of the bee. Even if we do not find the same hand as on Earth, finding extra-terrestrial optical rotation would be of enormous importance as it would still be the homochiral signature of life. copyright 1996 American Institute of Physics
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The Societal Impact of Extraterrestrial Life: The Relevance of History and the Social Sciences
Dick, Steven J.
This chapter reviews past studies on the societal impact of extraterrestrial life and offers four related ways in which history is relevant to the subject: the history of impact thus far, analogical reasoning, impact studies in other areas of science and technology, and studies on the nature of discovery and exploration. We focus particularly on the promise and peril of analogical arguments, since they are by necessity widespread in the field. This chapter also summarizes the relevance of the social sciences, particularly anthropology and sociology, and concludes by taking a closer look at the possible impact of the discovery of extraterrestrial life on theology and philosophy. In undertaking this study we emphasize three bedrock principles: (1) we cannot predict the future; (2) society is not monolithic, implying many impacts depending on religion, culture and worldview; (3) the impact of any discovery of extraterrestrial life is scenario-dependent.
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Geller, Harold A.
2014-01-01
I will discuss my research into the issues associated with the nature of any extraterrestrials that may be encountered in the future in our galaxy. This research was sparked by statements made by Stephen Hawking in 2010 regarding his fear of emitting radiation from our Earth so that an extraterrestrial intelligent civilization may be alerted to our existence in the galaxy today. While addressing issues of extraterrestrial altruism, a probabilistic equation was developed which addresses the number of extraterrestrial intelligent life forms that may exist in our galaxy today, who could use our bodies for nourishment or reproductive purposes. The equation begins with the results from a Drake Equation calculation, and proceeds by addressing such biochemical parameters as the fraction of ETIs with: dextro sugar stereo-isomers; levo amino acid stereo-isomers; similar codon interpretation; chromosomal length and, similar cell membrane structure to allow egg penetration.
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Study of extraterrestrial material by means of a high sensitive mass spectrometer, 1
International Nuclear Information System (INIS)
Arai, O.; Kaneko, K.; Kobayashi, K.; Shimamura, T.
1975-01-01
In this report it is described about a high sensitive mass spectrometer for measurement of isotopic abundance of extraterrestrial material. Detecting isotopic anomalies in extraterrestrial matter induced by cosmic ray or solar wind irradiation, we can obtain many informations about interplanetary and/or intersteller space. For this purpose we reform the mass spectrometer of Low Energy Physics Division of INS to improve the sensitivity and the resolution. In section I--VI some improvements of the mass spectrometer (vacuum system, ion source, collector etc.) are described. In section VII--X newly developed ion counting system is discussed. (auth.)
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Advances in Astromaterials Curation: Supporting Future Sample Return Missions
Evans, C. A.; Zeigler, R. A.; Fries, M. D..; Righter, K.; Allton, J. H.; Zolensky, M. E.; Calaway, M. J.; Bell, M. S.
2015-01-01
NASA's Astromaterials, curated at the Johnson Space Center in Houston, are the most extensive, best-documented, and leastcontaminated extraterrestrial samples that are provided to the worldwide research community. These samples include lunar samples from the Apollo missions, meteorites collected over nearly 40 years of expeditions to Antarctica (providing samples of dozens of asteroid bodies, the Moon, and Mars), Genesis solar wind samples, cosmic dust collected by NASA's high altitude airplanes, Comet Wild 2 and interstellar dust samples from the Stardust mission, and asteroid samples from JAXA's Hayabusa mission. A full account of NASA's curation efforts for these collections is provided by Allen, et al [1]. On average, we annually allocate about 1500 individual samples from NASA's astromaterials collections to hundreds of researchers from around the world, including graduate students and post-doctoral scientists; our allocation rate has roughly doubled over the past 10 years. The curation protocols developed for the lunar samples returned from the Apollo missions remain relevant and are adapted to new and future missions. Several lessons from the Apollo missions, including the need for early involvement of curation scientists in mission planning [1], have been applied to all subsequent sample return campaigns. From the 2013 National Academy of Sciences report [2]: "Curation is the critical interface between sample return missions and laboratory research. Proper curation has maintained the scientific integrity and utility of the Apollo, Antarctic meteorite, and cosmic dust collections for decades. Each of these collections continues to yield important new science. In the past decade, new state-of-the-art curatorial facilities for the Genesis and Stardust missions were key to the scientific breakthroughs provided by these missions." The results speak for themselves: research on NASA's astromaterials result in hundreds of papers annually, yield fundamental
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The Role of Extraterrestrial Materials in the Origin of Life
Sandford, Scott A.
2016-01-01
It has been well established for some time now that C-rich organic materials are relatively common in a number of environments in space. This is known through the telescopic detection of these materials using spectroscopy techniques in the infrared and sub-millimeter wavelength ranges and through the identification of organics in extraterrestrial materials. Extraterrestrial materials in which organics have been found include collected meteorites and interplanetary dust particles, and samples returned by NASA spacecraft from comets. These organics are produced by a variety of astrochemical processes. Despite their abiotic origins, these organic materials of are considerable interest to astrobiology for several reasons. First, organic materials of any composition are important as a means of delivering the elements C, H, O, and N to the surfaces of newly formed planets, and these elements are likely critical to the origin and subsequent evolution of life (certainly for life as we know it). In addition, it is clear that at least a portion of the organics found in space are in the form of molecules that play important roles in modern biology - for example, molecules like amino acids, amphiphiles, quinones, etc. Thus, the delivery of extraterrestrial organics to planetary surfaces brings not only bulk C, H, O, and N, but also molecular complexity in forms that are potentially useful for the origin and early evolution of life. This suggests that the production and delivery of cosmic organic compounds may have played key roles in the origin of life on Earth and, by extension, on other planets in the universe.
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Brown, I. I.; Bryant, D. A.; Tringe, S. G.; Malley, K.; Sosa, O.; Sarkisova, S. A.; Garrison, D. H.; McKay, D. S.
2010-04-01
Using genomic and metagenomic analysis, Fe-tolerant cyanobacterial species with a large and diverse set of stress-tolerant genes, were identified as prime candidates for in situ resource utilization in a biogeoreactor at extraterrestrial outposts.
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On the abundance of extraterrestrial life after the Kepler mission
Wandel, Amri
2015-07-01
The data recently accumulated by the Kepler mission have demonstrated that small planets are quite common and that a significant fraction of all stars may have an Earth-like planet within their habitable zone. These results are combined with a Drake-equation formalism to derive the space density of biotic planets as a function of the relatively modest uncertainty in the astronomical data and of the (yet unknown) probability for the evolution of biotic life, F b. I suggest that F b may be estimated by future spectral observations of exoplanet biomarkers. If F b is in the range 0.001-1, then a biotic planet may be expected within 10-100 light years from Earth. Extending the biotic results to advanced life I derive expressions for the distance to putative civilizations in terms of two additional Drake parameters - the probability for evolution of a civilization, F c, and its average longevity. For instance, assuming optimistic probability values (F b~F c~1) and a broadcasting longevity of a few thousand years, the likely distance to the nearest civilizations detectable by searching for intelligent electromagnetic signals is of the order of a few thousand light years. The probability of detecting intelligent signals with present and future radio telescopes is calculated as a function of the Drake parameters. Finally, I describe how the detection of intelligent signals would constrain the Drake parameters.
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CENTAR code for extended nonlinear transient analysis of extraterrestrial reactor systems
International Nuclear Information System (INIS)
Nassersharif, B.; Peer, J.S.; DeHart, M.D.
1987-01-01
Current interest in the application of nuclear reactor-driven power systems to space missions has generated a need for a systems simulation code to model and analyze space reactor systems; such a code has been initiated at Texas A and M, and the first version is nearing completion; release was anticipated in the fall of 1987. This code, named CENTAR (Code for Extended Nonlinear Transient Analysis of Extraterrestrial Reactor Systems), is designed specifically for space systems and is highly vectorizable. CENTAR is composed of several specialized modules. A fluids module is used to model fluid behavior throughout the system. A wall heat transfer module models the heat transfer characteristics of all walls, insulation, and structure around the system. A fuel element thermal analysis module is used to predict the temperature behavior and heat transfer characteristics of the reactor fuel rods. A kinetics module uses a six-group point kinetics formulation to model reactivity feedback and control and the ANS 5.1 decay-heat curve to model shutdown decay-heat production. A pump module models the behavior of thermoelectric-electromagnetic pumps, and a heat exchanger module models not only thermal effects in thermoelectric heat exchangers, but also predicts electrical power production for a given configuration. Finally, an accumulator module models coolant expansion/contraction accumulators
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Extraterrestrial cause for the Cretaceous-Tertiary extinction
International Nuclear Information System (INIS)
Alvarez, L.W.; Alvarez, W.; Asaro, F.; Michel, H.V.
1980-01-01
Platinum metals are depleted in the earth's crust relative to their cosmic abundance; concentrations of these elements in deep-sea sediments may thus indicate influxes of extraterrestrial material. Deep-sea limestones exposed in Italy, Denmark, and New Zealand show iridium increases of about 30, 160, and 20 times, respectively, above the background level at precisely the time of the Cretaceous-Tertiary extinctions, 65 million years ago. Reasons are given to indicate that this iridium is of extraterrestrial origin, but did not come from a nearby supernova. A hypothesis is suggested which accounts for the extinctions and the iridium observations. Impact of a large earth-crossing asteroid would inject about 60 times the object's mass into the atmosphere as pulverized rock; a fraction of this dust would stay in the stratosphere for several years and be distributed worldwide. The resulting darkness would suppress photosynthesis, and the expected biological consequences match quite closely the extinctions observed in the paleontological record. One prediction of this hypothesis has been verified: the chemical composition of the boundary clay, which is thought to come from the stratospheric dust, is markedly different from that of clay mixed with the Cretaceous and Tertiary limestones, which are chemically similar to each other. Four different independent estimates of the diameter of the asteroid give values that lie in the range 10 +- 4 kilometers
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Religions and extraterrestrial life how will we deal with it?
Weintraub, David A
2014-01-01
In the twenty-first century, the debate about life on other worlds is quickly changing from the realm of speculation to the domain of hard science. Within a few years, as a consequence of the rapid discovery by astronomers of planets around other stars, astronomers very likely will have discovered clear evidence of life beyond the Earth. Such a discovery of extraterrestrial life will change everything. Knowing the answer as to whether humanity has company in the universe will trigger one of the greatest intellectual revolutions in history, not the least of which will be a challenge for at least some terrestrial religions. Which religions will handle the discovery of extraterrestrial life with ease and which will struggle to assimilate this new knowledge about our place in the universe? Some religions as currently practiced appear to only be viable on Earth. Other religions could be practiced on distant worlds but nevertheless identify both Earth as a place and humankind as a species of singular spiritual re...
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Origin of spherule samples recovered from antarctic ice sheet-Terrestrial or extraterrestrial?
Energy Technology Data Exchange (ETDEWEB)
Sekimoto, Shun; Takamiya, Koichi; Shibata, Seiichi [Research Reactor Institute, Kyoto University, Osaka (Japan); Kobayashi, Takayuki [College of Humanities and Sciences, Nihon University, Tokyo (Japan); Ebihara, Mitsuru [Dept. of Chemistry, Tokyo Metropolitan University, Tokyo (Japan)
2016-04-15
Thirty-eight spherules from the Antarctic ice sheet were analyzed using neutron activation analysis under two different conditions to investigate their origin. In almost all of these spherules, the contents of iron, cobalt, and manganese were determined to be 31% to 88%, 17 mg/kg to 810 mg/kg, and 0.017% to 7%, respectively. A detectable iridium content of 0.84 mg/kg was found in only one spherule, which was judged to be extraterrestrial in origin. A comparison of elemental compositions of the Antarctic spherules analyzed in this study with those of deep-sea sediment spherules and those of terrestrial materials revealed that most of the Antarctic spherules except for the sample in which iridium was detected could not be identified as extraterrestrial in origin.
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Energy use, entropy and extra-terrestrial civilizations
International Nuclear Information System (INIS)
Hetesi, Zsolt
2010-01-01
The possible number of extra-terrestrial civilizations is estimated by the Drake-equation. Many articles pointed out that there are missing factors and over-estimations in the original equation. In this article we will point out that assuming some axioms there might be several limits for a technical civilization. The key role of the energy use and the problem of the centres and periphery strongly influence the value of the Llifetime of a civilization. Our development have several edifications of the investigations of the growth of an alien civilization.
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Energy use, entropy and extra-terrestrial civilizations
Energy Technology Data Exchange (ETDEWEB)
Hetesi, Zsolt, E-mail: zs.hetesi@astro.elte.h [Eoetvoes University, Department of Astronomy, Budapest, H-1518, PO Box 32 (Hungary)
2010-03-01
The possible number of extra-terrestrial civilizations is estimated by the Drake-equation. Many articles pointed out that there are missing factors and over-estimations in the original equation. In this article we will point out that assuming some axioms there might be several limits for a technical civilization. The key role of the energy use and the problem of the centres and periphery strongly influence the value of the Llifetime of a civilization. Our development have several edifications of the investigations of the growth of an alien civilization.
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Directory of Open Access Journals (Sweden)
Stefan Fox
2017-08-01
Full Text Available The “Rare Earth” hypothesis—put forward by Ward and Brownlee in their 2000 book of the same title—states that prokaryote-type organisms may be common in the universe but animals and higher plants are exceedingly rare. If this idea is correct, the search for extraterrestrial life is essentially the search for microorganisms. Various indicators may be used to detect extant or extinct microbial life beyond Earth. Among them are chemical biosignatures, such as biomolecules and stable isotope ratios. The present minireview focuses on the major problems associated with the identification of chemical biosignatures. Two main types of misinterpretation are distinguished, namely false positive and false negative results. The former can be caused by terrestrial biogenic contaminants or by abiotic products. Terrestrial contamination is a common problem in space missions that search for biosignatures on other planets and moons. Abiotic organics can lead to false positive results if erroneously interpreted as biomolecules, but also to false negatives, for example when an abiotic source obscures a less productive biological one. In principle, all types of putative chemical biosignatures are prone to misinterpretation. Some, however, are more reliable (“stronger” than others. These include: (i homochiral polymers of defined length and sequence, comparable to proteins and polynucleotides; (ii enantiopure compounds; (iii the existence of only a subset of molecules when abiotic syntheses would produce a continuous range of molecules; the proteinogenic amino acids constitute such a subset. These considerations are particularly important for life detection missions to solar system bodies such as Mars, Europa, and Enceladus.
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Olson, S. L.; Beeson, H.; Haas, J. P.
2003-01-01
The objective of this project is to modify the standard oxygen consumption (cone) calorimeter (described in ASTM E 1354 and NASA STD 6001 Test 2) to provide a reproducible bench-scale test environment that simulates the buoyant or ventilation flow that would be generated by or around a burning surface in a spacecraft or extraterrestrial gravity level. This apparatus will allow us to conduct normal gravity experiments that accurately and quantitatively evaluate a material's flammability characteristics in the real-use environment of spacecraft or extra-terrestrial gravitational acceleration. The Equivalent Low Stretch Apparatus (ELSA) uses an inverted cone geometry with the sample burning in a ceiling fire configuration that provides a reproducible bench-scale test environment that simulates the buoyant or ventilation flow that would be generated by a flame in a spacecraft or extraterrestrial gravity level. Prototype unit testing results are presented in this paper. Ignition delay times and regression rates for PMMA are presented over a range of radiant heat flux levels and equivalent stretch rates which demonstrate the ability of ELSA to simulate key features of microgravity and extraterrestrial fire behavior.
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International Nuclear Information System (INIS)
Kelly, William M.; Low, Nora M.; Zillmer, Andrew; Johnson, Gregory A.; Normand, Eugene
2006-01-01
The Multi-Mission Radioisotope Thermoelectric Generator (MMRTG) is the next generation (RTG) being developed by DOE to provide reliable, long-life electric power for NASA's planetary exploration programs. The MMRTG is being developed by Pratt and Whitney Rocketdyne and Teledyne Energy Systems Incorporated (TESI) for use on currently planned and projected flyby, orbital and planet landing missions. This is a significant departure from the design philosophy of the past which was to match specific mission requirements to RTG design capabilities. Undefined mission requirements provide a challenge to system designers by forcing them to put a design envelope around 'all possible missions'. These multi-mission requirements include internal and external radiation sources. Internal sources include the particles ejected by decaying Pu-238 and its daughters plus particles resulting from the interaction of these particles with other MMRTG materials. External sources include the full spectrum of charged particle radiation surrounding planets with magnetic fields and the surfaces of extraterrestrial objects not shielded by magnetic fields. The paper presents the results of investigations into the environments outlined above and the impact of radiation exposure on potential materials to be used on MMRTG and ground support personnel. Mission requirements were also reviewed to evaluate total integrated dose and to project potential shielding requirements for materials. Much of the information on mission shielding requirements was provided by NASA's Jet Propulsion Laboratory. The primary result is an ionizing radiation design curve which indicates the limits to which a particular mission can take the MMRTG in terms of ionizing radiation exposure. Estimates of personnel radiation exposure during ground handling are also provided
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Thermal Design for Extra-Terrestrial Regenerative Fuel Cell System
Gilligan, R.; Guzik, M.; Jakupca, I.; Bennett, W.; Smith, P.; Fincannon, J.
2017-01-01
The Advanced Exploration Systems (AES) Advanced Modular Power Systems (AMPS) Project is investigating different power systems for various lunar and Martian mission concepts. The AMPS Fuel Cell (FC) team has created two system-level models to evaluate the performance of regenerative fuel cell (RFC) systems employing different fuel cell chemistries. Proton Exchange Membrane fuel cells PEMFCs contain a polymer electrolyte membrane that separates the hydrogen and oxygen cavities and conducts hydrogen cations (protons) across the cell. Solid Oxide fuel cells (SOFCs) operate at high temperatures, using a zirconia-based solid ceramic electrolyte to conduct oxygen anions across the cell. The purpose of the modeling effort is to down select one fuel cell chemistry for a more detailed design effort. Figures of merit include the system mass, volume, round trip efficiency, and electrolyzer charge power required. PEMFCs operate at around 60 C versus SOFCs which operate at temperatures greater than 700 C. Due to the drastically different operating temperatures of the two chemistries the thermal control systems (TCS) differ. The PEM TCS is less complex and is characterized by a single pump cooling loop that uses deionized water coolant and rejects heat generated by the system to the environment via a radiator. The solid oxide TCS has its own unique challenges including the requirement to reject high quality heat and to condense the steam produced in the reaction. This paper discusses the modeling of thermal control systems for an extraterrestrial RFC that utilizes either a PEM or solid oxide fuel cell.
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Rodgers, Erica M.; Simon, Matthew A.; Antol, Jeffrey; Chai, Patrick R.; Jones, Christopher A.; Klovstad, Jordan J.; Neilan, James H.; Stillwagen, Frederic H.; Williams, Phillip A.; Bednara, Michael;
2015-01-01
The path from Earth to Mars requires exploration missions to be increasingly Earth-independent as the foundation is laid for a sustained human presence in the following decades. NASA pioneering of Mars will expand the boundaries of human exploration, as a sustainable presence on the surface requires humans to successfully reproduce in a partial gravity environment independent from Earth intervention. Before significant investment is made in capabilities leading to such pioneering efforts, the challenges of multigenerational mammalian reproduction in a partial gravity environment need be investigated. The Multi-generational Independent Colony for Extraterrestrial Habitation, Autonomy, and Behavior health is designed to study these challenges. The proposed concept is a conceptual, long duration, autonomous habitat designed to house rodents in a partial gravity environment with the goal of understanding the effects of partial gravity on mammalian reproduction over multiple generations and how to effectively design such a facility to operate autonomously while keeping the rodents healthy in order to achieve multiple generations. All systems are designed to feed forward directly to full-scale human missions to Mars. This paper presents the baseline design concept formulated after considering challenges in the mission and vehicle architectures such as: vehicle automation, automated crew health management/medical care, unique automated waste disposal and hygiene, handling of deceased crew members, reliable long-duration crew support systems, and radiation protection. This concept was selected from an architectural trade space considering the balance between mission science return and robotic and autonomy capabilities. The baseline design is described in detail including: transportation and facility operation constraints, artificial gravity system design, habitat design, and a full-scale mock-up demonstration of autonomous rodent care facilities. The proposed concept has
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Is Your Gut Conscious? Is an Extraterrestrial?
Vos Post, Jonathan
2011-10-01
This paper speculates on questions intending to be taken scientifically rather than metaphysically: "Can the human gut (enteric nervous system) be conscious?"; "Can your immune system think?"; "Could consciousness be coded in DNA?"; "What do we mean when asserting that an Extraterrestrial is Thinking, or is Conscious? We explore through reference to theory, experiment, and computational models by Christof Koch (Caltech), Barbara Wold (Caltech), and Stuart Kauffman (University of Calgary, Tampere University of Technology, Santa Fe Institute). We use a tentative new definition of thinking, designed to be applicable for humans, cetecea, corvids, artificial intelligences, and extraterrestrial intelligences of any substrate (i.e. Life as We Do Not Know It): "Thinking is the occurrence, transformation, and storage in a mind or brain (or simulation thereof) of information-bearing structures (representations) of one kind or another, such as thoughts, concept, percepts, ideas, impressions, notions, rules, schemas, images, phantasms, or subpersonal representations." We use the framework for Consciousness developed by Francis Crick and Christof Koch. We try to describe scientific goals, but discuss Philosophy sufficient to avoid naïve philosophical category errors (thus are careful not to conflate thought, consciousness, and language) Penrose, Hameroff, and Kauffman speculate (differently) that CNS consciousness is a macroscopic quantum phenomenon. Might intestinal, immune system, or genetic regulatory network dynamics exhibit emergent cooperative quantum effects? The speculations are in the context of Evolution by Natural Selection, presumed to operate throughout the Cosmos, and recent work in the foundations of Computational Biology and Quantum Mechanics.
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Analytical SuperSTEM for extraterrestrial materials research
Energy Technology Data Exchange (ETDEWEB)
Bradley, J P; Dai, Z R
2009-09-08
Electron-beam studies of extraterrestrial materials with significantly improved spatial resolution, energy resolution and sensitivity are enabled using a 300 keV SuperSTEM scanning transmission electron microscope with a monochromator and two spherical aberration correctors. The improved technical capabilities enable analyses previously not possible. Mineral structures can be directly imaged and analyzed with single-atomic-column resolution, liquids and implanted gases can be detected, and UV-VIS optical properties can be measured. Detection limits for minor/trace elements in thin (<100 nm thick) specimens are improved such that quantitative measurements of some extend to the sub-500 ppm level. Electron energy-loss spectroscopy (EELS) can be carried out with 0.10-0.20 eV energy resolution and atomic-scale spatial resolution such that variations in oxidation state from one atomic column to another can be detected. Petrographic mapping is extended down to the atomic scale using energy-dispersive x-ray spectroscopy (EDS) and energy-filtered transmission electron microscopy (EFTEM) imaging. Technical capabilities and examples of the applications of SuperSTEM to extraterrestrial materials are presented, including the UV spectral properties and organic carbon K-edge fine structure of carbonaceous matter in interplanetary dust particles (IDPs), x-ray elemental maps showing the nanometer-scale distribution of carbon within GEMS (glass with embedded metal and sulfides), the first detection and quantification of trace Ti in GEMS using EDS, and detection of molecular H{sub 2}O in vesicles and implanted H{sub 2} and He in irradiated mineral and glass grains.
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Miniature Time of Flight Mass Spectrometer for Space and Extraterrestrial Applications, Phase II
National Aeronautics and Space Administration — The PI has developed a miniature time-of-flight mass spectrometer (TOF-MS), which can be op-timized for space and extraterrestrial applications, by using a...
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Exploring the Human Ecology of the Younger Dryas Extraterrestrial Impact Event
Kennett, D. J.; Erlandson, J. M.; Braje, T. J.; Culleton, B. J.
2007-05-01
Several lines of evidence now exist for a major extraterrestrial impact event in North America at 12.9 ka (the YDB). This impact partially destabilized the Laurentide and Cordilleran ice sheets, triggered abrupt Younger Dryas cooling and extensive wildfires, and contributed to megafaunal extinction. This event also occurred soon after the well established colonization of the Americas by anatomically modern humans. Confirmation of this event would represent the first near-time extraterrestrial impact with significant effects on human populations. These likely included widespread, abrupt human mortality, population displacement, migration into less effected or newly established habitats, loss of cultural traditions, and resource diversification in the face of the massive megafaunal extinction and population reductions in surviving animal populations. Ultimately, these transformations established the context for the special character of plant and animal domestication and the emergence of agricultural economies in North America. We explore the Late Pleistocene archaeological record in North America within the context of documented major biotic changes associated with the YDB in North America and of the massive ecological affects hypothesized for this event.
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The Younger Dryas climate change: was it caused by an extraterrestrial impact?
van Hoesel, A.
2014-01-01
The Younger Dryas is an abrupt cooling event at the end of the last Glacial associated to a change in ocean circulation. According to the Younger Dryas impact hypothesis, however, one or more extraterrestrial airbursts or impacts occuring around 12.8 ka caused the Younger Dryas cooling, extensive
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Borowski, Stanley K.; Corban, Robert R.; Culver, Donald W.; Bulman, Melvin J.; McIlwain, Mel C.
1994-08-01
The concept of a liquid oxygen (LOX)-augmented nuclear thermal rocket (NTR) engine is introduced, and its potential for revolutionizing lunar space transportation system (LTS) performance using extraterrestrial 'lunar-derived' liquid oxygen (LUNOX) is outlined. The LOX-augmented NTR (LANTR) represents the marriage of conventional liquid hydrogen (LH2)-cooled NTR and airbreathing engine technologies. The large divergent section of the NTR nozzle functions as an 'afterburner' into which oxygen is injected and supersonically combusted with nuclear preheated hydrogen emerging from the NTR's choked sonic throat: 'scramjet propulsion in reverse.' By varying the oxygen-to-fuel mixture ratio (MR), the LANTR concept can provide variable thrust and specific impulse (Isp) capability with a LH2-cooled NTR operating at relatively constant power output. For example, at a MR = 3, the thrust per engine can be increased by a factor of 2.75 while the Isp decreases by only 30 percent. With this thrust augmentation option, smaller, 'easier to develop' NTR's become more acceptable from a mission performance standpoint (e.g., earth escape gravity losses are reduced and perigee propulsion requirements are eliminated). Hydrogen mass and volume is also reduced resulting in smaller space vehicles. An evolutionary NTR-based lunar architecture requiring only Shuttle C and/or 'in-line' shuttle-derived launch vehicles (SDV's) would operate initially in an 'expandable mode' with NTR lunar transfer vehicles (LTV's) delivering 80 percent more payload on piloted missions than their LOX/LH2 chemical propulsion counterparts. With the establishment of LUNOX production facilities on the lunar surface and 'fuel/oxidizer' depot in low lunar orbit (LLO), monopropellant NTR's would be outfitted with an oxygen propellant module, feed system, and afterburner nozzle for 'bipropellant' operation. The LANTR cislunar LTV now transitions to a reusable mode with smaller vehicle and payload doubling benefits on
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Mainstream Media and Social Media Reactions to the Discovery of Extraterrestrial Life
Jones, Morris
The rise of online social media (such as Facebook and Twitter) has overturned traditional top-down and stovepiped channels for mass communications. As social media have risen, traditional media sources have been steadily crippled by economic problems, resulting in a loss of capabilities and credibility. Information can propagate rapidly without the inclusion of traditional editorial checks and controls. Mass communications strategies for any type of major announcement must account for this new media landscape. Scientists announcing the discovery of extraterrestrial life will trigger a multifaceted and unpredictable percolation of the story through the public sphere. They will also potentially struggle with misinformation, rumours and hoaxes. The interplay of official announcements with the discussions of an extraterrestrial discovery on social media has parallels with traditional theories of mass communications. A wide spectrum of different messages is likely to be received by different segments of the community, based on their usage patterns of various media and online communications. The presentation and interpretation of a discovery will be hotly debated and contested within online media environments. In extreme cases, this could lead to "editorial wars" on collaborative media projects as well as cyber-attacks on certain online services and individuals. It is unlikely that a clear and coherent message can be propagated to a near-universal level. This has the potential to contribute to inappropriate reactions in some sectors of the community. Preventing unnecessary panic will be a priority. In turn, the monitoring of online and social media will provide a useful tool for assessing public reactions to a discovery of extraterrestrial life. This will help to calibrate public communications strategies following in the wake of an initial announcement.
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IMPERA: Integrated Mission Planning for Multi-Robot Systems
Directory of Open Access Journals (Sweden)
Daniel Saur
2015-10-01
Full Text Available This paper presents the results of the project IMPERA (Integrated Mission Planning for Distributed Robot Systems. The goal of IMPERA was to realize an extraterrestrial exploration scenario using a heterogeneous multi-robot system. The main challenge was the development of a multi-robot planning and plan execution architecture. The robot team consists of three heterogeneous robots, which have to explore an unknown environment and collect lunar drill samples. The team activities are described using the language ALICA (A Language for Interactive Agents. Furthermore, we use the mission planning system pRoPhEt MAS (Reactive Planning Engine for Multi-Agent Systems to provide an intuitive interface to generate team activities. Therefore, we define the basic skills of our team with ALICA and define the desired goal states by using a logic description. Based on the skills, pRoPhEt MAS creates a valid ALICA plan, which will be executed by the team. The paper describes the basic components for communication, coordinated exploration, perception and object transportation. Finally, we evaluate the planning engine pRoPhEt MAS in the IMPERA scenario. In addition, we present further evaluation of pRoPhEt MAS in more dynamic environments.
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Siderophilic Cyanobacteria for the Development of Extraterrestrial Photoautotrophic Biotechnologies
Brown, I. I.; McKay, D. S.
2010-01-01
In-situ production of consumables (mainly oxygen) using local resources (In-Situ Resource Utilization-ISRU) will significantly facilitate current plans for human exploration and settlement of the solar system, starting with the Moon. With few exceptions, nearly all technologies developed to date have employed an approach based on inorganic chemistry. None of these technologies include concepts for integrating the ISRU system with a bioregenerative life support system and a food production system. Therefore, a new concept based on the cultivation of cyanobacteria (CB) in semi-closed biogeoreactor, linking ISRU, a biological life support system, and food production, has been proposed. The key feature of the biogeoreactor is to use lithotrophic CB to extract many needed elements such as Fe directly from the dissolved regolith and direct them to any technological loop at an extraterrestrial outpost. Our studies showed that siderophilic (Fe-loving) CB are capable to corrode lunar regolith stimulants because they secrete chelating agents and can tolerate [Fe] up to 1 mM. However, lunar and Martian environments are very hostile (very high UV and gamma-radiation, extreme temperatures, deficit of water). Thus, the selection of CB species with high potential for extraterrestrial biotechnologies that may be utilized in 15 years must be sponsored by NASA as soon as possible. The study of the genomes of candidate CB species and the metagenomes of the terrestrial environments which they inhabit is critical to make this decision. Here we provide preliminary results about peculiarities of the genomes of siderophilic CB revealed by analyzing the genome of siderophilic cyanobacterium JSC-1 and the metagenome of iron depositing hot spring (IDHS) Chocolate Pots (Yellowstone National Park, Wyoming, USA). It has been found that IDHS are richer with ferrous iron than the majority of hot springs around the world. Fe2+ is known to increase the magnitude of oxidative stress in prokaryotes
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The Search for Extraterrestrial Intelligence in the 1960s: Science in Popular Culture
Smith, Sierra
2012-01-01
Building upon the advancement of technology during the Second World War and the important scientific discoveries which have been made about the structure and components of the universe, scientists, especially in radio astronomy and physics, began seriously addressing the possibility of extraterrestrial intelligence in the 1960s. The Search for Extraterrestrial Intelligence (SETI) quickly became one of the most controversial scientific issues in the post Second World War period. The controversy played out, not only in scientific and technical journals, but in newspapers and in popular literature. Proponents for SETI, including Frank Drake, Carl Sagan, and Philip Morrison, actively used a strategy of engagement with the public by using popular media to lobby for exposure and funding. This paper will examine the use of popular media by scientists interested in SETI to popularize and heighten public awareness and also to examine the effects of popularization on SETI's early development. My research has been generously supported by the National Radio Astronomy Observatory.
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Narusawa, Shin-ya; Aota, Tatusya; Kishimoto, Ryo
2018-04-01
In the case of radio SETI, there are predicted frequencies which extraterrestrial beings select to send messages to other civilizations. Those are called ;magic frequencies. Considering the optical region, terrestrial technologies can not transmit arbitrary wavelengths of high-power optical lasers, easily. In this article, we discuss communications among civilizations with the same level of technology as us to enhance the persuasive power. It might be possible to make a reasonable assumption about the laser wavelengths transmitted by extraterrestrial intelligences to benefit optical SETI (OSETI) methods. Therefore, we propose some ;magic wavelengths; for spectroscopic OSETI observations in this article. From the senders point of view, we argue that the most favorable wavelength used for interstellar communication would be the one of YAG lasers, at 1.064 μm or its Second Harmonic Generation (532.1 nm). On the contrary, there are basic absorption lines in the optical spectra, which are frequently observed by astrophysicists on Earth. It is possible that the extraterrestrials used lasers, which wavelengths are tuned to such absorption lines for sending messages. In that case, there is a possibility that SHG and/or Sum Frequency Generation of YAG and YLF lasers are used. We propose three lines at, 393.8 nm (near the Ca K line), 656.5 nm (near the Hα line) and 589.1 nm (Na D2 line) as the magic wavelengths.
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Telling, Jon; Lacrampe-Couloume, Georges; Sherwood Lollar, Barbara
2013-05-01
The low-molecular-weight alkanes--methane, ethane, propane, and butane--are found in a wide range of terrestrial and extraterrestrial settings. The development of robust criteria for distinguishing abiogenic from biogenic alkanes is essential for current investigations of Mars' atmosphere and for future exobiology missions to other planets and moons. Here, we show that alkanes synthesized during gas-phase radical recombination reactions in electrical discharge experiments have values of δ(2)H(methane)>δ(2)H(ethane)>δ(2)H(propane), similar to those of the carbon isotopes. The distribution of hydrogen isotopes in gas-phase radical reactions is likely due to kinetic fractionations either (i) from the preferential incorporation of (1)H into longer-chain alkanes due to the more rapid rate of collisions of the smaller (1)H-containing molecules or (ii) by secondary ion effects. Similar δ(13)C(C1-C2+) and δ(2)H(C1-C2+) patterns may be expected in a range of extraterrestrial environments where gas-phase radical reactions dominate, including interstellar space, the atmosphere and liquid hydrocarbon lakes of Saturn's moon Titan, and the outer atmospheres of Jupiter, Saturn, Neptune, and Uranus. Radical recombination reactions at high temperatures and pressures may provide an explanation for the combined reversed δ(13)C(C1-C2+) and δ(2)H(C1-C2+) patterns of terrestrial alkanes documented at a number of high-temperature/pressure crustal sites.
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Sample Handling and Processing on Mars for Future Astrobiology Missions
Beegle, Luther; Kirby, James P.; Fisher, Anita; Hodyss, Robert; Saltzman, Alison; Soto, Juancarlos; Lasnik, James; Roark, Shane
2011-01-01
In most analytical investigations, there is a need to process complex field samples for the unique detection of analytes especially when detecting low concentration organic molecules that may identify extraterrestrial life. Sample processing for analytical instruments is time, resource and manpower consuming in terrestrial laboratories. Every step in this laborious process will have to be automated for in situ life detection. We have developed, and are currently demonstrating, an automated wet chemistry preparation system that can operate autonomously on Earth and is designed to operate under Martian ambient conditions. This will enable a complete wet chemistry laboratory as part of future missions. Our system, namely the Automated Sample Processing System (ASPS) receives fines, extracts organics through solvent extraction, processes the extract by removing non-organic soluble species and delivers sample to multiple instruments for analysis (including for non-organic soluble species).
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Extraterrestrial materials examined by mean of nuclear microprobe
Khodja, H.; Smith, T.; Engrand, C.; Herzog, G.; Raepsaet, C.
2013-07-01
Comet fragments, micrometeorites, and Interplanetary Dust Particles (IDPs) are small objects (purpose, we need instruments and methods that provide both microanalysis and detailed imaging. In these respects, the nuclear microprobe offers many potential advantages: (i) the spatial resolution, ∼1 μm is well-matched to the typical object dimensions, (ii) with some reservations, it is non-destructive when carefully conducted, (iii) it is quantitative, and especially sensitive for light elements. At the Saclay nuclear microprobe, we have been performing analyses of extraterrestrial objects for many years. We review some of these studies, emphasizing the specific requirements for successful analyses. We also discuss the potential pitfalls that may be encountered.
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Qi, Bin; Guo, Linli; Zhang, Zhixian
2016-07-01
Space life science and life support engineering are prominent problems in manned deep space exploration mission. Some typical problems are discussed in this paper, including long-term life support problem, physiological effect and defense of varying extraterrestrial environment. The causes of these problems are developed for these problems. To solve these problems, research on space life science and space medical-engineering should be conducted. In the aspect of space life science, the study of space gravity biology should focus on character of physiological effect in long term zero gravity, co-regulation of physiological systems, impact on stem cells in space, etc. The study of space radiation biology should focus on target effect and non-target effect of radiation, carcinogenicity of radiation, spread of radiation damage in life system, etc. The study of basic biology of space life support system should focus on theoretical basis and simulating mode of constructing the life support system, filtration and combination of species, regulation and optimization method of life support system, etc. In the aspect of space medical-engineering, the study of bio-regenerative life support technology should focus on plants cultivation technology, animal-protein production technology, waste treatment technology, etc. The study of varying gravity defense technology should focus on biological and medical measures to defend varying gravity effect, generation and evaluation of artificial gravity, etc. The study of extraterrestrial environment defense technology should focus on risk evaluation of radiation, monitoring and defending of radiation, compound prevention and removal technology of dust, etc. At last, a case of manned lunar base is analyzed, in which the effective schemes of life support system, defense of varying gravity, defense of extraterrestrial environment are advanced respectively. The points in this paper can be used as references for intensive study on key
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Cost-Effective Icy Bodies Exploration using Small Satellite Missions
Jonsson, Jonas; Mauro, David; Stupl, Jan; Nayak, Michael; Aziz, Jonathan; Cohen, Aaron; Colaprete, Anthony; Dono-Perez, Andres; Frost, Chad; Klamm, Benjamin;
2015-01-01
It has long been known that Saturn's moon Enceladus is expelling water-rich plumes into space, providing passing spacecraft with a window into what is hidden underneath its frozen crust. Recent discoveries indicate that similar events could also occur on other bodies in the solar system, such as Jupiter's moon Europa and the dwarf planet Ceres in the asteroid belt. These plumes provide a possible giant leap forward in the search for organics and assessing habitability beyond Earth, stepping stones toward the long-term goal of finding extraterrestrial life. The United States Congress recently requested mission designs to Europa, to fit within a cost cap of $1B, much less than previous mission designs' estimates. Here, innovative cost-effective small spacecraft designs for the deep-space exploration of these icy worlds, using new and emerging enabling technologies, and how to explore the outer solar system on a budget below the cost horizon of a flagship mission, are investigated. Science requirements, instruments selection, rendezvous trajectories, and spacecraft designs are some topics detailed. The mission concepts revolve around a comparably small-sized and low-cost Plume Chaser spacecraft, instrumented to characterize the vapor constituents encountered on its trajectory. In the event that a plume is not encountered, an ejecta plume can be artificially created by a companion spacecraft, the Plume Maker, on the target body at a location timed with the passage of the Plume Chaser spacecraft. Especially in the case of Ceres, such a mission could be a great complimentary mission to Dawn, as well as a possible future Europa Clipper mission. The comparably small volume of the spacecraft enables a launch to GTO as a secondary payload, providing multiple launch opportunities per year. Plume Maker's design is nearly identical to the Plume Chaser, and fits within the constraints for a secondary payload launch. The cost-effectiveness of small spacecraft missions enables the
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Limits on diffuse fluxes of high energy extraterrestrial neutrinos with the AMANDA-B10 detector
International Nuclear Information System (INIS)
Ahrens, J.; Bai, X.; Barwick, S.W.; Bay, R.C.; Becka, T.; Becker, K.-H.; Bernardini, E.; Bertrand, D.; Binon, F.; Boeser, S.; Botner, O.; Bouchta, A.; Bouhali, O.; Burgess, T.; Carius, S.; Castermans, T.; Chirkin, D.; Conrad, J.; Cooley, J.; Cowen, D.F.; Davour, A.; De Clercq, C.; DeYoung, T.; Desiati, P.; Doksus, P.; Ekstrom, P.; Feser, T.; Gaisser, T.K.; Ganugapati, R.; Gaug, M.; Geenen, H.; Gerhardt, L.; Goldschmidt, A.; Hallgren, A.; Halzen, F.; Hanson, K.; Hardtke, R.; Hauschildt, T.; Hellwig, M.; Herquet, P.; Hill, G.C.; Hulth, P.O.; Hughey, B.; Hultqvist, K.; Hundertmark, S.; Jacobsen, J.; Karle, A.; Kuehn, K.; Kim, J.; Kopke, L.; Kowalski, M.; Lamoureux, J.I.; Leich, H.; Leuthold, M.; Lindahl, P.; Liubarsky, I.; Madsen, J.; Mandli, K.; Marciniewski, P.; Matis, H.S.; McParland, C.P.; Messarius, T.; Miller, T.C.; Minaeva, Y.; Miocinovic, P.; Mock, P.C.; Morse, R.; Neunhoffer, T.; Niessen, P.; Nygren, D.R.; Ogelman, H.; Olbrechts, P.; Perez de los Heros, C.; Pohl, A.C.; Porrata, R.; Price, P.B.; Przybylski, G.T.; Rawlins, K.; Resconi, E.; Rhode, W.; Ribordy, M.; Richter, S.; Rodriguez Martino, J.; Romenesko, P.; Ross, D.; Sander, H.-G.; Schlenstedt, S.; Schinarakis, K.; Schmidt, T.; Schneider, D.; Schwarz, R.; Silvestri, A.; Solarz, M.; Stamatikos, M.; Spiczak, G.M.; Spiering, C.; Steele, D.; Steffen, P.; Stokstad, R.G.; Sulanke, K.-H.; Taboada, I.; Tilav, S.; Wagner, W.; Walck, C.; Wang, Y.-R.; Wiebusch, C.H.; Wiedemann, C.; Wischnewski, R.; Wissing, H.; Woschnagg, K.; Wu, W.; Yodh, G.; Young, S.
2003-01-01
Data from the AMANDA-B10 detector taken during the austral winter of 1997 have been searched for a diffuse flux of high energy extraterrestrial muon-neutrinos, as predicted from, e.g., the sum of all active galaxies in the universe. This search yielded no excess events above those expected from the background atmospheric neutrinos, leading to upper limits on the extraterrestrial neutrino flux. For an assumed E -2 spectrum, a 90 percent classical confidence level upper limit has been placed at a level E 2 Phi(E) = 8.4 x 10 -7 GeV cm -2 s -1 1 sr -1 (for a predominant neutrino energy range 6-1000 TeV) which is the most restrictive bound placed by any neutrino detector. When specific predicted spectral forms are considered, it is found that some are excluded
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Habitability and the Possibility of Extraterrestrial Life in the Early Telescope Era
Reynolds, Sarah
2014-01-01
Early telescopic observations of the Moon and planets prompted great interest in the already-existing debate about the possibility of life on the Moon and other worlds. New observations of the lunar surface, revealing an apparently Earth-like terrain and possibly the presence of bodies of water, were often considered in relation to their implications for the existence of lunar inhabitants. This depended upon establishing what constituted the fundamental requirements for life and the boundaries of habitability. The growing support for the heliocentric Copernican astronomy was also changing perceptions of the relationships between the Earth, the Moon, and the planets. Works such as Johannes Kepler’s Somnium and John Wilkins’ The Discovery of a World in the Moone presented views of extraterrestrial life that were shifting from the supernatural to the natural, in correspondence with the celestial bodies’ new positions in the cosmos. This paper considers how these and other works from the early telescope era reveal changes in the nature of astronomical speculation about extraterrestrial life and the conditions construed as “habitability,” and what significance that history has for us today in the new era of extrasolar planet discovery.
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International Nuclear Information System (INIS)
Seifritz, W.; Vath, W.
1992-01-01
This paper reports on the recirculating power fraction of a laser-driven inertial confinement fusion (ICF) reactor which can be reduced by using laser diodes to pump a neodymium solid-state laser. To overcome the high costs of two-dimensional arrays of laser diodes, two types of superresonators are proposed: a terrestrially based one and an extraterrestrially based one on a geostationary orbit. Both are designed in such a way that a sequence of short laser pulses (10 to 20 ns wide), each with an energy of 5 to 10 MJ and a frequency of 10 Hz, are produced to trigger a deuterium-tritium ICF reactor. The terrestrial superresonator needs a much smaller number of two-dimensional laser diode arrays than a conventionally pumped once-through solid-state laser system, and the extraterrestrial resonator is pumped by means of concentrated solar radiation. In practice, at least an order of magnitude fewer laser diodes and crystalline calcium fluoride gain media are needed to meet the requirements of a laser driver for an ICF reactor. If, finally, a liquid neodymium laser system could be used for an ICF reactor, the cooling of the gain slabs would be facilitated substantially
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The G-HAT Search for Advanced Extraterrestrial Civilizations: The Reddest Extended WISE Sources
Maldonado, Jessica; Povich, Matthew S.; Wright, Jason; Griffith, Roger; Sigurdsson, Steinn; Mullan, Brendan L.
2015-01-01
Freeman Dyson (1960) theorized how to identify possible signatures of advanced extra-terrestrial civilizations by their waste heat, an inevitable byproduct of a civilization using a significant fraction of the luminosity from their host star. If a civilizations could tap the starlight throughout their host galaxy their waste heat would be easily detectable by recent infrared surveys. The Glimpsing Heat from Alien Technologies (G-HAT) pilot project aims to place limits on the existence of extraterrestrial civilizations at pan-galactic scales. We present results from the G-HAT cleaned catalog of 563 extremely red, extended high Galactic latitude (|b| ≥ 10) sources from the WISE All-Sky Catalog. Our catalog includes sources new to the scientific literature along with well-studied objects (e.g. starburst galaxies, AGN, and planetary nebulae) that exemplify extreme WISE colors. Objects of particular interest include a supergiant Be star (48 Librae) surrounded by a resolved, mid-infrared nebula, possibly indicating dust in the stellar wind ejecta, and a curious cluster of seven extremely red WISE sources (associated with IRAS 04287+6444) that have no optical counterparts.
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Rose, Christopher; Wright, Gregory
2004-09-02
It is well known that electromagnetic radiation-radio waves-can in principle be used to communicate over interstellar distances. By contrast, sending physical artefacts has seemed extravagantly wasteful of energy, and imagining human travel between the stars even more so. The key consideration in earlier work, however, was the perceived need for haste. If extraterrestrial civilizations existed within a few tens of light years, radio could be used for two-way communication on timescales comparable to human lifetimes (or at least the longevities of human institutions). Here we show that if haste is unimportant, sending messages inscribed on some material can be strikingly more energy efficient than communicating by electromagnetic waves. Because messages require protection from cosmic radiation and small messages could be difficult to find among the material clutter near a recipient, 'inscribed matter' is most effective for long archival messages (as opposed to potentially short "we exist" announcements). The results suggest that our initial contact with extraterrestrial civilizations may be more likely to occur through physical artefacts-essentially messages in a bottle-than via electromagnetic communication.
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Human Health and Performance Aspects of the Mars Design Reference Mission
Charles, John B.
2000-01-01
This paper will describe the current planning for exploration-class missions, emphasizing the medical, and human factors aspects of such expeditions. The details of mission architecture are still under study, but a typical Mars design reference mission comprises a six-month transit from Earth to Mar, eighteen months in residence on Mars, and a six-month transit back to Earth. Physiological stressors will include environmental factors such as prolonged exposure to radiation, weightlessness in transit, and hypogravity and a toxic atmosphere while on Mars. Psychological stressors will include remoteness from Earth, confinement, and potential interpersonal conflicts, all complicated by circadian alterations. Medical risks including trauma must also be considered. Results of planning for assuring human health and performance will be presented.
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Search for extraterrestrial life: recent developments. Proceedings
Energy Technology Data Exchange (ETDEWEB)
Papagiannis, M D [ed.
1985-01-01
Seventy experts from 20 different countries discuss the many interrelated aspects of the search for extraterrestrial life, including the search for other planetary systems where life may originate and evolve, the widespread presence of complex prebiotic molecules in our Solar System and in interstellar space which could be precursors of life, and the universal aspects of the biological evolution on Earth. They also discuss the nearly 50 radio searches that were undertaken in the last 25 years, the technological progress that has occurred in this period, and the plans for the future including the comprehensive SETI search program that NASA is now preparing for the 1990's. Extensive introductions by the Editor to each of the 8 sections, make this volume friendly even to the non-specialist who has a genuine interest for this new field. 549 refs.; 84 figs.; 21 tabs.
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Directory of Open Access Journals (Sweden)
Mathias Basner
Full Text Available Behavioral health risks are among the most serious and difficult to mitigate risks of confinement in space craft during long-duration space exploration missions. We report on behavioral and psychological reactions of a multinational crew of 6 healthy males confined in a 550 m(3 chamber for 520 days during the first Earth-based, high-fidelity simulated mission to Mars. Rest-activity of crewmembers was objectively measured throughout the mission with wrist-worn actigraphs. Once weekly throughout the mission crewmembers completed the Beck Depression Inventory-II (BDI-II, Profile of Moods State short form (POMS, conflict questionnaire, the Psychomotor Vigilance Test (PVT-B, and series of visual analogue scales on stress and fatigue. We observed substantial inter-individual differences in the behavioral responses of crewmembers to the prolonged mission confinement and isolation. The crewmember with the highest average POMS total mood disturbance score throughout the mission also reported symptoms of depression in 93% of mission weeks, which reached mild-to-moderate levels in >10% of mission weeks. Conflicts with mission control were reported five times more often than conflicts among crewmembers. Two crewmembers who had the highest ratings of stress and physical exhaustion accounted for 85% of the perceived conflicts. One of them developed a persistent sleep onset insomnia with ratings of poor sleep quality, which resulted in chronic partial sleep deprivation, elevated ratings of daytime tiredness, and frequent deficits in behavioral alertness. Sleep-wake timing was altered in two other crewmembers, beginning in the first few months of the mission and persisting throughout. Two crewmembers showed neither behavioral disturbances nor reports of psychological distress during the 17-month period of mission confinement. These results highlight the importance of identifying behavioral, psychological, and biological markers of characteristics that
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Transportation Packages to Support Savannah River Site Missions
International Nuclear Information System (INIS)
Opperman, E.
2001-01-01
The Savannah River Site's missions have expanded from primarily a defense mission to one that includes environmental cleanup and the stabilization, storage, and preparation for final disposition of nuclear materials. The development of packaging and the transportation of radioactive materials are playing an ever-increasing role in the successful completion of the site's missions. This paper describes the Savannah River Site and the three strategic mission areas of (1) nuclear materials stewardship, (2) environmental stewardship, and (3) nuclear weapons stockpile stewardship. The materials and components that need to be shipped, and associated packaging, will be described for each of the mission areas. The diverse range of materials requiring shipment include spent fuel, irradiated target assemblies, excess plutonium and uranium materials, high level waste canisters, transuranic wastes, mixed and low level wastes, and nuclear weapons stockpile materials and components. Since many of these materials have been in prolonged storage or resulted from disassembly of components, the composition, size and shape of the materials present packaging and certification challenges that need to be met. Over 30 different package designs are required to support the site's missions. Approximately 15 inbound shipping-legs transport materials into the Savannah River Site and the same number (15) of outgoing shipment-legs are carrying materials from the site for further processing or permanent disposal
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Planetary protection issues related to human missions to Mars
Debus, A.; Arnould, J.
2008-09-01
In accordance with the United Nations Outer Space Treaties [United Nations, Agreement Governing the Activities of States on the Moon and Other Celestial Bodies, UN doc A/RES/34/68, resolution 38/68 of December 1979], currently maintained and promulgated by the Committee on Space Research [COSPAR Planetary Protection Panel, Planetary Protection Policy accepted by the COSPAR Council and Bureau, 20 October 2002, amended 24 March 2005, http://www.cosparhq.org/scistr/PPPolicy.htm], missions exploring the Solar system must meet planetary protection requirements. Planetary protection aims to protect celestial bodies from terrestrial contamination and to protect the Earth environment from potential biological contamination carried by returned samples or space systems that have been in contact with an extraterrestrial environment. From an exobiology perspective, Mars is one of the major targets, and several missions are currently in operation, in transit, or scheduled for its exploration. Some of them include payloads dedicated to the detection of life or traces of life. The next step, over the coming years, will be to return samples from Mars to Earth, with a view to increasing our knowledge in preparation for the first manned mission that is likely to take place within the next few decades. Robotic missions to Mars shall meet planetary protection specifications, currently well documented, and planetary protection programs are implemented in a very reliable manner given that experience in the field spans some 40 years. With regards to sample return missions, a set of stringent requirements has been approved by COSPAR [COSPAR Planetary Protection Panel, Planetary Protection Policy accepted by the COSPAR Council and Bureau, 20 October 2002, amended 24 March 2005, http://www.cosparhq.org/scistr/PPPolicy.htm], and technical challenges must now be overcome in order to preserve the Earth’s biosphere from any eventual contamination risk. In addition to the human dimension of
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Mcelroy, J. F.
1990-01-01
Viewgraphs on SPE regenerative hydrogen/oxygen fuel cells for extraterrestrial surface and microgravity applications are presented. Topics covered include: hydrogen-oxygen regenerative fuel cell energy storage system; electrochemical cell reactions; SPE cell voltage stability; passive water removal SPE fuel cell; fuel cell performance; SPE water electrolyzers; hydrophobic oxygen phase separator; hydrophilic/electrochemical hydrogen phase separator; and unitized regenerative fuel cell.
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Are we alone: The possibility of extraterrestrial civilizations
Rood, R. T.; Trefil, J. S.
The book explores the possibility of extraterrestrial (ET) intelligence. The formation of stars and planetary systems, the evolution of planetary atmospheres and the evolution of life are reviewed. The possibilities of interstellar communication, ET colonization of other star systems, in addition to earth's colonization of near-earth space are discussed. The state of the earth's depleting energy sources and current technology are used to show why some scientists believe that earth will be colonizing in space within the next century. Current methods of searching for ET intelligence are reviewed, and preliminary designs for various space habitats, including the torus, and discussed, taking into consideration problems that would be encountered. The importance of space colonies for the existence and expansion of the human race is emphasized.
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Isotopic evidence for extraterrestrial non- racemic amino acids in the Murchison meteorite
Engel, M. H.; Macko, S. A.
1997-09-01
Many amino acids contain an asymmetric centre, occurring as laevorotatory, L, or dextrorotatory, D, compounds. It is generally assumed that abiotic synthesis of amino acids on the early Earth resulted in racemic mixtures (L- and D-enantiomers in equal abundance). But the origin of life required, owing to conformational constraints, the almost exclusive selection of either L- or D-enantiomers, and the question of why living systems on the Earth consist of L-enantiomers rather than D-enantiomers is unresolved. A substantial fraction of the organic compounds on the early Earth may have been derived from comet and meteorite impacts. It has been reported previously that amino acids in the Murchison meteorite exhibit an excess of L-enantiomers, raising the possibility that a similar excess was present in the initial inventory of organic compounds on the Earth. The stable carbon isotope compositions of individual amino acids in Murchison support an extraterrestrial origin-rather than a terrestrial overprint of biological amino acids-although reservations have persisted (see, for example, ref. 9). Here we show that individual amino-acid enantiomers from Murchison are enriched in 15N relative to their terrestrial counterparts, so confirming an extraterrestrial source for an L-enantiomer excess in the Solar System that may predate the origin of life on the Earth.
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Biomedical Aspects of Lunar and Mars Exploration Missions
Charles, John B.
2006-01-01
Recent long-range planning for exploration-class missions has emphasized the need for anticipating the medical and human factors aspects of such expeditions. Missions returning Americans to the moon for stays of up to 6 months at a time will provide the opportunity to demonstrate the means to function safely and efficiently on another planet. Details of mission architectures are still under study, but a typical Mars design reference mission comprises a six-month transit from Earth to Mars, eighteen months in residence on Mars, and a six-month transit back to Earth. Physiological stresses will come from environmental factors such as prolonged exposure to radiation, weightlessness en route to Mars and then back to Earth, and low gravity and a toxic atmosphere while on Mars. Psychological stressors will include remoteness from Earth, confinement, and potential interpersonal conflicts, all complicated by circadian alterations. Medical risks including trauma must be considered. The role of such risk-modifying influences as artificial gravity and improved propulsion technologies to shorten round-trip time will also be discussed. Results of planning for assuring human health and performance will be presented.
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Prolonged silicon carbide integrated circuit operation in Venus surface atmospheric conditions
Directory of Open Access Journals (Sweden)
Philip G. Neudeck
2016-12-01
Full Text Available The prolonged operation of semiconductor integrated circuits (ICs needed for long-duration exploration of the surface of Venus has proven insurmountably challenging to date due to the ∼ 460 °C, ∼ 9.4 MPa caustic environment. Past and planned Venus landers have been limited to a few hours of surface operation, even when IC electronics needed for basic lander operation are protected with heavily cumbersome pressure vessels and cooling measures. Here we demonstrate vastly longer (weeks electrical operation of two silicon carbide (4H-SiC junction field effect transistor (JFET ring oscillator ICs tested with chips directly exposed (no cooling and no protective chip packaging to a high-fidelity physical and chemical reproduction of Venus’ surface atmosphere. This represents more than 100-fold extension of demonstrated Venus environment electronics durability. With further technology maturation, such SiC IC electronics could drastically improve Venus lander designs and mission concepts, fundamentally enabling long-duration enhanced missions to the surface of Venus.
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Development of an Indexing Media Filtration System for Long Duration Space Missions
Agui, Juan H.; Vijayakumar, R.
2013-01-01
The effective maintenance of air quality aboard spacecraft cabins will be vital to future human exploration missions. A key component will be the air cleaning filtration system which will need to remove a broad size range of particles derived from multiple biological and material sources. In addition, during surface missions any extraterrestrial planetary dust, including dust generated by near-by ISRU equipment, which is tracked into the habitat will also need to be managed by the filtration system inside the pressurized habitat compartments. An indexing media filter system is being developed to meet the demand for long-duration missions that will result in dramatic increases in filter service life and loading capacity, and will require minimal crew involvement. The filtration system consists of three stages: an inertial impactor stage, an indexing media stage, and a high-efficiency filter stage, packaged in a stacked modular cartridge configuration. Each stage will target a specific range of particle sizes that optimize the filtration and regeneration performance of the system. An 1/8th scale and full-scale prototype of the filter system have been fabricated and have been tested in the laboratory and reduced gravity environments that simulate conditions on spacecrafts, landers and habitats. Results from recent laboratory and reduce-gravity flight tests data will be presented. The features of the new filter system may also benefit other closed systems, such as submarines, and remote location terrestrial installations where servicing and replacement of filter units is not practical.
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Directory of Open Access Journals (Sweden)
Silje A. Wolff
2014-05-01
Full Text Available Due to logistical challenges, long-term human space exploration missions require a life support system capable of regenerating all the essentials for survival. Higher plants can be utilized to provide a continuous supply of fresh food, atmosphere revitalization, and clean water for humans. Plants can adapt to extreme environments on Earth, and model plants have been shown to grow and develop through a full life cycle in microgravity. However, more knowledge about the long term effects of the extraterrestrial environment on plant growth and development is necessary. The European Space Agency (ESA has developed the Micro-Ecological Life Support System Alternative (MELiSSA program to develop a closed regenerative life support system, based on micro-organisms and higher plant processes, with continuous recycling of resources. In this context, a literature review to analyze the impact of the space environments on higher plants, with focus on gravity levels, magnetic fields and radiation, has been performed. This communication presents a roadmap giving directions for future scientific activities within space plant cultivation. The roadmap aims to identify the research activities required before higher plants can be included in regenerative life support systems in space.
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Life from the stars?. [extraterrestrial sources contributing to chemical evolution on Earth
Pendleton, Yvonne J.; Cruikshank, Dale P.
1994-01-01
Scientists are now seriously considering the possibility that organic matter from interstellar space could have influenced, or even spurred, the origin of life on Earth. Various aspects of chemical evolution are discussed along with possible extraterrestrial sources responsible for contributing to Earth's life-producing, chemical composition. Specific topics covered include the following: interstellar matter, molecular clouds, asteroid dust, organic molecules in our solar system, interplanetary dust and comets, meteoritic composition, and organic-rich solar-system bodies.
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Extraterrestrial Organic Compounds in Meteorites
Botta, Oliver; Bada, Jeffrey L.; Meyer, Michael (Technical Monitor)
2003-01-01
Many organic compounds or their precursors found in meteorites originated in the interstellar or circumstellar medium and were later incorporated into planetesimals during the formation of the solar system. There they either survived intact or underwent further processing to synthesize secondary products on the meteorite parent body. The most distinct feature of CI and CM carbonaceous chondrites, two types of stony meteorites, is their high carbon content (up to 3% of weight), either in the form of carbonates or of organic compounds. The bulk of the organic carbon consists of an insoluble macromolecular material with a complex structure. Also present is a soluble organic fraction, which has been analyzed by several separation and analytical procedures. Low detection limits can be achieved by derivatization of the organic molecules with reagents that allow for analysis by gas chromatography/mass spectroscopy and high performance liquid chromatography. The CM meteorite Murchison has been found to contain more than 70 extraterrestrial amino acids and several other classes of compounds including carboxylic acids, hydroxy carboxylic acids, sulphonic and phosphonic acids, aliphatic, aromatic and polar hydrocarbons, fullerenes, heterocycles as well as carbonyl compounds, alcohols, amines and amides. The organic matter was found to be enriched in deuterium, and distinct organic compounds show isotopic enrichments of carbon and nitrogen relative to terrestrial matter.
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The Search for Extraterrestrials Intercepting Alien Signals
Ross, Monte
2009-01-01
In The Search for Extraterrestrials, Monte Ross explores in detail the key problems in starting a search, the programs that have failed and those that continue. He includes the fundamental considerations and the physics of the necessary laser, UV, IR and RF technologies, as well as coding and information theory considerations. The author explores future possibilities providing the reader with a comprehensive view of the many ways signals from aliens could be sent and explains why the search using RF leaves more than 99% of the electromagnetic spectrum unexamined. He also demonstrates the many parts of the electromagnetic spectrum, considering the next likely steps in this unique enterprise. Given man’s intrinsic nature to explore, the search will continue in one form or many, until success is achieved, which may be tomorrow or a millennium away. In summary, Monte Ross proposes to get around the failure of a fruitless search at radio frequencies by developing, in a precise way, the argument for searching for...
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McCubbin, F. M.; Allton, J. H.; Barnes, J. J.; Boyce, J. W.; Burton, A. S.; Draper, D. S.; Evans, C. A.; Fries, M. D.; Jones, J. H.; Keller, L. P.;
2017-01-01
The Astromaterials Acquisition and Curation Office (henceforth referred to herein as NASA Curation Office) at NASA Johnson Space Center (JSC) is responsible for curating all of NASA's extraterrestrial samples. JSC presently curates 9 different astromaterials collections: (1) Apollo samples, (2) LUNA samples, (3) Antarctic meteorites, (4) Cosmic dust particles, (5) Microparticle Impact Collection [formerly called Space Exposed Hardware], (6) Genesis solar wind, (7) Star-dust comet Wild-2 particles, (8) Stardust interstellar particles, and (9) Hayabusa asteroid Itokawa particles. In addition, the next missions bringing carbonaceous asteroid samples to JSC are Hayabusa 2/ asteroid Ryugu and OSIRIS-Rex/ asteroid Bennu, in 2021 and 2023, respectively. The Hayabusa 2 samples are provided as part of an international agreement with JAXA. The NASA Curation Office plans for the requirements of future collections in an "Advanced Curation" program. Advanced Curation is tasked with developing procedures, technology, and data sets necessary for curating new types of collections as envisioned by NASA exploration goals. Here we review the science value and sample curation needs of some potential targets for sample return missions over the next 35 years.
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NASA-ESA Joint Mission to Explore Two Worlds of Great Astrobiological Interest - Titan and Enceladus
Reh, K.; Coustenis, A.; Lunine, J.; Matson, D.; Lebreton, J.-P.; Erd, C.; Beauchamp, P.
2009-04-01
Rugged shorelines, laced with canyons, leading to ethane/methane seas glimpsed through an organic haze, vast fields of dunes shaped by alien sciroccos… An icy moon festooned with plumes of water-ice and organics, whose warm watery source might be glimpsed through surface cracks that glow in the infrared… The revelations by Cassini-Huygens about Saturn's crown jewels, Titan and Enceladus, have rocked the public with glimpses of new worlds unimagined a decade before. The time is at hand to capitalize on those discoveries with a broad mission of exploration that combines the widest range of planetary science disciplines—Geology, Geophysics, Atmospheres, Astrobiology,Chemistry, Magnetospheres—in a single NASA/ESA collaboration. The Titan Saturn System Mission will explore these exciting new environments, flying through Enceladus' plumes and plunging deep into Titan's atmosphere with instruments tuned to find what Cassini could only hint at. Exploring Titan with an international fleet of vehicles; from orbit, from the surface of a great polar sea, and from the air with the first hot air balloon to ride an extraterrestrial breeze, TSSM will turn our snapshot gaze of these worlds into an epic film. This paper will describe a collaborative NASA-ESA Titan Saturn System Mission that will open a new phase of planetary exploration by projecting robotic presence on the land, on the sea, and in the air of an active, organic-rich world.
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Extraterrestrial Life: Life on Mars - Then and Now
Arrhenius, Gustaf; Mojzsis, Stephen
1996-01-01
The recent claim to have identified possible signs of ancient life on Mars has been widely publicized and discussed. The authors conceded that none of the half-dozen pieces of evidence adduced in their paper individually provided strong support for extraterrestrial life, though they argued that the pieces added up to a case worth considering. Most - perhaps all - of the observed phenomena have counterparts in the inorganic world, so even the combination does not make a compelling case that there was ever life on Mars. Nevertheless, the importance of the problem has justified bringing the results to general attention. The paper has focussed interest on the origin and possible ubiquity of life, and on how we can design techniques capable of giving a more definitive answer to the question of whether there is, or has ever been, life elsewhere in the Universe.
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Project Cyclops: a Design Study of a System for Detecting Extraterrestrial Intelligent Life
1972-01-01
The requirements in hardware, manpower, time and funding to conduct a realistic effort aimed at detecting the existence of extraterrestrial intelligent life are examined. The methods used are limited to present or near term future state-of-the-art techniques. Subjects discussed include: (1) possible methods of contact, (2) communication by electromagnetic waves, (3) antenna array and system facilities, (4) antenna elements, (5) signal processing, (6) search strategy, and (7) radio and radar astronomy.
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Glavin, Daniel P.; Dworkin, Jason P.; Lupisella, Mark; Kminek, Gerhard; Rummel, John D.
2010-01-01
NASA and ESA have outlined visions for solar system exploration that will include a series of lunar robotic precursor missions to prepare for, and support a human return to the Moon, and future human exploration of Mars and other destinations. One of the guiding principles for exploration is to pursue compelling scientific questions about the origin and evolution of life. The search for life on objects such as Mars will require that all spacecraft and instrumentation be sufficiently cleaned and sterilized prior to launch to ensure that the scientific integrity of extraterrestrial samples is not jeopardized by terrestrial organic contamination. Under the Committee on Space Research's (COSPAR's) current planetary protection policy for the Moon, no sterilization procedures are required for outbound lunar spacecraft, nor is there yet a planetary protection category for human missions. Future in situ investigations of a variety of locations on the Moon by highly sensitive instruments designed to search for biologically derived organic compounds would help assess the contamination of the Moon by lunar spacecraft. These studies could also provide valuable "ground truth" data for Mars sample return missions and help define planetary protection requirements for future Mars bound spacecraft carrying life detection experiments. In addition, studies of the impact of terrestrial contamination of the lunar surface by the Apollo astronauts could provide valuable data to help refine future Mars surface exploration plans for a human mission to Mars.
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The Extraterrestrial Materials Simulation Laboratory
Green, J. R.
2001-01-01
In contrast to fly-by and orbital missions, in situ missions face an incredible array of challenges in near-target navigation, landing site selection, descent, landing, science operations, sample collection and handling, drilling, anchoring, subsurface descent, communications, and contamination. The wide range of materials characteristics and environments threaten mission safety and success. For example, many physical properties are poorly characterized, including strength, composition, heterogeneity, phase change, texture, thermal properties, terrain features, atmospheric interaction, and stratigraphy. Examples of the range of materials properties include, for example: (1) Comets, with a possible compressive strength ranging from a light fluff to harder than concrete: 10(exp 2) to 10 (exp 8) Pa; (2) Europa, including a possible phase change at the surface, unknown strength and terrain roughness; and (3) Titan, with a completely unknown surface and possible liquid ocean. Additional information is contained in the original extended abstract.
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Extraterrestrial material analysis: loss of amino acids during liquid-phase acid hydrolysis
Buch, Arnaud; Brault, Amaury; Szopa, Cyril; Freissinet, Caroline
2015-04-01
Searching for building blocks of life in extraterrestrial material is a way to learn more about how life could have appeared on Earth. With this aim, liquid-phase acid hydrolysis has been used, since at least 1970 , in order to extract amino acids and other organic molecules from extraterrestrial materials (e.g. meteorites, lunar fines) or Earth analogues (e.g. Atacama desert soil). This procedure involves drastic conditions such as heating samples in 6N HCl for 24 h, either under inert atmosphere/vacuum, or air. Analysis of the hydrolyzed part of the sample should give its total (free plus bound) amino acid content. The present work deals with the influence of the 6N HCl hydrolysis on amino acid degradation. Our experiments have been performed on a standard solution of 17 amino acids. After liquid-phase acid hydrolysis (6N HCl) under argon atmosphere (24 h at 100°C), the liquid phase was evaporated and the dry residue was derivatized with N-Methyl-N-(t-butyldimethylsilyl)trifluoroacetamide (MTBSTFA) and dimethylformamide (DMF), followed by gas chromatography-mass spectrometry analysis. After comparison with derivatized amino acids from the standard solution, a significant reduction of the chromatographic peak areas was observed for most of the amino acids after liquid-phase acid hydrolysis. Furthermore, the same loss pattern was observed when the amino acids were exposed to cold 6N HCl for a short amount of time. The least affected amino acid, i.e. glycine, was found to be 73,93% percent less abundant compared to the non-hydrolyzed standard, while the most affected, i.e. histidine, was not found in the chromatograms after hydrolysis. Our experiments thereby indicate that liquid-phase acid hydrolysis, even under inert atmosphere, leads to a partial or total loss of all of the 17 amino acids present in the standard solution, and that a quick cold contact with 6N HCl is sufficient to lead to a loss of amino acids. Therefore, in the literature, the reported increase
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Extraterrestrial amino acids in Cretaceous/Tertiary boundary sediments at Stevns Klint, Denmark
Zhao, Meixun; Bada, Jeffrey L.
1989-06-01
SINCE the discovery1 nearly a decade ago that Cretaceous/Tertiary (K/T) boundary layers are greatly enriched in iridium, a rare element in the Earth's crust, there has been intense controversy on the relationship between this Ir anomaly and the massive extinction of organisms ranging from dinosaurs to marine plankton that characterizes the K/T boundary. Convincing evidence suggests that both the Ir spike and the extinction event were caused by the collision of a large bolide (>10 km in diameter) with the Earth1-11. Alternative explanations claim that extensive, violent volcanism12-14 can account for the Ir, and that other independent causes were responsible for the mass extinctions15,16. We surmise that the collision of a massive extraterrestrial object with the Earth may have produced a unique organic chemical signature because certain meteorites, and probably comets, contain organic compounds which are either rare or non-existent on the Earth17. In contrast, no organic compounds would be expected to be associated with volcanic processes. Here we find that K/T boundary sediments at Stevns Klint, Denmark, contain both α-amino-isobutyric acid [AIB, (CH3)2CNH2COOH] and racemic isovaline [ISOVAL, CH3CH2(CH3)CNH2COOH], two amino acids that are exceedingly rare on the Earth but which are major amino acids in carbonaceous chondrites17,18. An extraterrestrial source is the most reasonable explanation for the presence of these amino acids.
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Heart Rate Response During Mission-Critical Tasks After Space Flight
Arzeno, Natalia M.; Lee, S. M. C.; Stenger, M. B.; Lawrence, E. L.; Platts, S. H.; Bloomberg, J. J.
2010-01-01
Adaptation to microgravity could impair crewmembers? ability to perform required tasks upon entry into a gravity environment, such as return to Earth, or during extraterrestrial exploration. Historically, data have been collected in a controlled testing environment, but it is unclear whether these physiologic measures result in changes in functional performance. NASA?s Functional Task Test (FTT) aims to investigate whether adaptation to microgravity increases physiologic stress and impairs performance during mission-critical tasks. PURPOSE: To determine whether the well-accepted postflight tachycardia observed during standard laboratory tests also would be observed during simulations of mission-critical tasks during and after recovery from short-duration spaceflight. METHODS: Five astronauts participated in the FTT 30 days before launch, on landing day, and 1, 6, and 30 days after landing. Mean heart rate (HR) was measured during 5 simulations of mission-critical tasks: rising from (1) a chair or (2) recumbent seated position followed by walking through an obstacle course (egress from a space vehicle), (3) translating graduated masses from one location to another (geological sample collection), (4) walking on a treadmill at 6.4 km/h (ambulation on planetary surface), and (5) climbing 40 steps on a passive treadmill ladder (ingress to lander). For tasks 1, 2, 3, and 5, astronauts were encouraged to complete the task as quickly as possible. Time to complete tasks and mean HR during each task were analyzed using repeated measures ANOVA and ANCOVA respectively, in which task duration was a covariate. RESULTS: Landing day HR was higher (P < 0.05) than preflight during the upright seat egress (7%+/-3), treadmill walk (13%+/-3) and ladder climb (10%+/-4), and HR remained elevated during the treadmill walk 1 day after landing. During tasks in which HR was not elevated on landing day, task duration was significantly greater on landing day (recumbent seat egress: 25
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Extraterrestrial Nucleobases in Carbonaceous Chondrites
Martins, Z.; Botta, O.; Fogel, M.; Sephton, M.; Glavin, D.; Watson, J.; Dworkin, J.; Schwartz, A.; Ehrenfreund, P.
. Our stable carbon isotope measurements clearly demonstrate that the nucleobases in the Murchison meteorite are indigenous to the meteorite, and clearly differ from the values determined for the terrestrial nucleobases measured in the soil collected at the impact site. These results support the hypothesis that nucleobases were exogenously delivered to the early Earth, and may have been important for the prebiotic chemistry on our young planet. With regard to the detection of traces of life on other planets such as Mars it is essential to characterize organic materials that have been exogenously delivered to the early planets. The analysis of the composition and isotopic fractionation of extraterrestrial material using complementary techniques can provide crucial insights into the formation of our Solar System, extraterrestrial delivery processes and subsequent addition and incorporation into the carbonaceous material available on the young planets. Ultimately, these parameters form an essential reference point for interpreting biosignatures that may be left in the ancient rock record on a planetary body. References: [1] Hayatsu R. et al. 1975. Geochimica et Cosmochimica Acta 39: 471- 488. [2] Folsome C. E. et al. 1971. Nature 232: 108-109. [3] Stoks P. G. & Schwartz A. W. 1979. Nature 282: 709-710. [4] Stoks P.G. & Schwartz A. W. 1981. Geochimica et Cosmochimica Acta 45: 563-569. [5] Shimoyama A. et al. 1990. Geochemical Journal 24: 343-348. [6] Martins Z. et al. 2004. Meteoritics & Planetary Science 39: A5145. 2
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Analysis and control of macro - and microorganisms interactions for missions of different duration
Somova, L.; Pechurkin, N.
In developing different t pes of life support systems for use in space or extremey environments Earth, researchers should pay attention to the functional state and stability of such systems. Special attention has been given to the interactions between macro- and microorganisms. Microorganisms are considered the most suitable indicators of a system's health and its component links. We can divide all space missions into types by which the behavior of man microbe interactions may be categorized: short missions and long ones. For short missions sanitary and hygiene procedures can be used to control the microflora of open and / or physico -chemical systems of life support. F r more prolonged missions hygieneo provisions may become inadequate and opportunistic infection occur rapidly. In general we should understand that the task of maintaining the heals of human being under conditions of stress is not only a question of sanitation and hygiene, but also a problem of the ecological balance within the habitat.
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Development of extraterrestrial intelligence and physical laws
Troitskij, V. S.
This paper considers the restrictions imposed by physical laws on the development of life and intelligence in the form of extraterrestrial civilizations. For this purpose intelligence is defined as the community of intelligent beings, joined by the exchange of mass, energy and information both between themselves and with the external medium. Due to the limitation of the velocity of exchange of information and, in particular, mass and energy exchange, the dimensions of the intelligence cannot exceed some light days, i.e. they are limited by the habitable zone about their star. It is shown that the energy consumption should not exceed the energy output of their star for the sake of preserving the cosmic near-star zone of life from energetic pollution. With the above restrictions of the energy product it takes millions of years to create an omnidirectional beacon-transmitter signals from which would be received by the contemporary antennas in all our Galaxy. It is realistic to create an omnidirectional beacon operating in the range of no more than 100-1000 light years.
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A Review of Extra-Terrestrial Mining Concepts
Mueller, R. P.; van Susante, P. J.
2012-01-01
Outer space contains a vast amount of resources that offer virtually unlimited wealth to the humans that can access and use them for commercial purposes. One of the key technologies for harvesting these resources is robotic mining of regolith, minerals, ices and metals. The harsh environment and vast distances create challenges that are handled best by robotic machines working in collaboration with human explorers. Humans will benefit from the resources that will be mined by robots. They will visit outposts and mining camps as required for exploration, commerce and scientific research, but a continuous presence is most likely to be provided by robotic mining machines that are remotely controlled by humans. There have been a variety of extra-terrestrial robotic mining concepts proposed over the last 40 years and this paper will attempt to summarize and review concepts in the public domain (government, industry and academia) to serve as an informational resource for future mining robot developers and operators. The challenges associated with these concepts will be discussed and feasibility will be assessed. Future needs associated with commercial efforts will also be investigated.
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Inflation-Theory Implications for Extraterrestrial Visitation
Deardoff, J.; Haisch, B.; Maccabee, B.; Puthoff, H. E.
It has recently been argued that anthropic reasoning applied to inflation theory reinforces the prediction that we should find ourselves part of a large, galaxy-sized civilisation, thus strengthening Fermi's paradox concerning `Where are they?' Furthermore, superstring and M-brane theory allow for the possibility of parallel universes, some of which in principle could be habitable. In addition, discussion of such exotic transport concepts as `traversable wormholes' now appears in the rigorous physics literature. As a result, the `We are alone' solution to Fermi's paradox, based on the constraints of earlier 20th century viewpoints, appears today to be inconsistent with new developments in our best current physics and astrophysics theories. Therefore we reexamine and reevaluate the present assumption that extraterrestrials or their probes are not in the vicinity of Earth, and argue instead that some evidence of their presence might be found in certain high-quality UFO reports. This study follows up on previous arguments that (1) interstellar travel for advanced civilizations is not a priori ruled out by physical principles and therefore may be practicable, and (2) such advanced civilisations may value the search for knowledge from uncontaminated species more than direct, interspecies communication, thereby accounting for apparent covertness regarding their presence.
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Caraccio, Anne; Poulet, Lucie; Hintze, Paul E.; Miles, John D.
2014-01-01
Future crewed missions to other planets or deep space locations will require regenerative Life Support Systems (LSS) as well as recycling processes for mission waste. Constant resupply of many commodity materials will not be a sustainable option for deep space missions, nor will stowing trash on board a vehicle or at a lunar or Martian outpost. The habitable volume will decline as the volume of waste increases. A complete regenerative environmentally controlled life support system (ECLSS) on an extra-terrestrial outpost will likely include physico-chemical and biological technologies, such as bioreactors and greenhouse modules. Physico-chemical LSS do not enable food production and bio-regenerative LSS are not stable enough to be used alone in space. Mission waste that cannot be recycled into the bio-regenerative ECLSS can include excess food, food packaging, clothing, tape, urine and fecal waste. This waste will be sent to a system for converting the trash into high value products. Two crew members on a 120 day Mars analog simulation, in collaboration with Kennedy Space Centers (KSC) Trash to Gas (TtG) project investigated a semi-closed loop system that treated non-edible biomass and other logistical waste for volume reduction and conversion into useful commodities. The purpose of this study is to show how plant growth affects the amount of resources required by the habitat and how spent plant material can be recycled. Real-time data was sent to the reactor at KSC in Florida for replicating the analog mission waste for laboratory operation. This paper discusses the 120 day mission plant growth activity, logistical and plant waste management, power and water consumption effects of the plant and logistical waste, and potential energy conversion techniques using KSCs TtG technology.
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Caraccio, Anne; Poulet, Lucie; Hintze, Paul E.; Miles, John D.
2014-01-01
Future crewed missions to other planets or deep space locations will require regenerative Life Support Systems (LSS) as well as recycling processes for mission waste. Constant resupply of many commodity materials will not be a sustainable option for deep space missions, nor will storing trash on board a vehicle or at a lunar or Martian outpost. The habitable volume will decline as the volume of waste increases. A complete regenerative environmentally controlled life support system (ECLSS) on an extra-terrestrial outpost will likely include physico-chemical and biological technologies, such as bioreactors and greenhouse modules. Physico-chemical LSS do not enable food production and bio-regenerative LSS are not stable enough to be used alone in space. Mission waste that cannot be recycled into the bio-regenerative ECLSS can include excess food, food packaging, clothing, tape, urine and fecal waste. This waste will be sent to a system for converting the trash into the high value products. Two crew members on a 120 day Mars analog simulation, in collaboration with Kennedy Space Centers (KSC) Trash to Gas (TtG) project investigated a semi-closed loop system that treated non-edible biomass and other logistical waste for volume reduction and conversion into useful commodities. The purposes of this study are to show the how plant growth affects the amount of resources required by the habitat and how spent plant material can be recycled. Real-time data was sent to the reactor at KSC in Florida for replicating the analog mission waste for laboratory operation. This paper discusses the 120 day mission plant growth activity, logistical and plant waste management, power and water consumption effects of the plant and logistical waste, and potential energy conversion techniques using KSCs TtG reactor technology.
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Webb, Stephen
2002-01-01
Given the fact that there are perhaps 400 million stars in our Galaxy alone, and perhaps 400 million galaxies in the Universe, it stands to reason that somewhere out there, in the 14-billion-year-old cosmos, there is or once was a civilization at least as advanced as our own. The sheer enormities of the numbers almost demand that we accept the truth of this hypothesis. Why, then, have we encountered no evidence, no messages, no artifacts of these extraterrestrials? Webb discusses in detail the 50 most cogent and intriguing solutions to Fermi's famous paradox: If the numbers strongly point to the existence of extraterrestrial civilizations, why have we found no evidence of them?
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Energy Technology Data Exchange (ETDEWEB)
NONE
2004-04-01
Licences of US nuclear reactors were initially attributed for a 40 years duration. However, the vast majority of the reactors can benefit of a licence prolongation for a period of 20 years maximum. This article recalls first the procedure to follow for the licence prolongation demands (safety analysis, components aging, environmental impact statement), and then it makes a status of the accepted prolongations, of the demands under examination, and of the demands that should be presented in the next 5 years. (J.S.)
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Amino Acids from Icy Amines: A Radiation-Chemical Approach to Extraterrestrial Synthesis
Dworkin, J. P.; Moore, M. H.
2010-01-01
Detections of amino acids in meteorites go back several decades, with at least 100 such compounds being reported for the Murchison meteorite alone. The presence of these extraterrestrial molecules raises questions as to their formation, abundance, thermal stability, racemization, and possible subsequent reactions. Although all of these topics have been studied in laboratories, such work often involves many variables and unknowns. This has led us to seek out model systems with which to uncover reaction products, test chemical predictions, and sited light on underlying reaction mechanisms. This presentation will describe one such study, focusing on amino-acid formation in ices.
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Quality of drug label information on QT interval prolongation
DEFF Research Database (Denmark)
Warnier, Miriam J; Holtkamp, Frank A; Rutten, Frans H
2014-01-01
BACKGROUND: Information regarding QT-prolongation in the drug label may vary between products. This could lead to suboptimal risk minimization strategies. OBJECTIVE: To systematically assess the variation in the extent and content of information on QT prolongation in the summary of product......-prolongation'/'QT-prolongation') and the advice on cautionary measures pertaining to QT-prolongation in the label were examined, as well as their association. RESULTS: Of the 175 screened products, 44 contained information on QT in the SPC ('no QT-prolongation': 23%, 'unclear drug-QT association': 43%, 'possibly QT-prolongation': 16%, 'QT......-prolongation': 18%). 62% contained advices to act with caution in patients with additional risk factors for QT-prolongation. Products that more likely to have QT-prolonging properties according to the SPC provided more information on QT-prolongation in the SPC ('no prolongation': 10% and for the category 'QT...
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Olson, S. L.; Beeson, H.; Haas, J.
2001-01-01
One of the performance goals for NASA's enterprise of Human Exploration and Development of Space (HEDS) is to develop methods, data bases, and validating tests for material flammability characterization, hazard reduction, and fire detection/suppression strategies for spacecraft and extraterrestrial habitats. This work addresses these needs by applying the fundamental knowledge gained from low stretch experiments to the development of a normal gravity low stretch material flammability test method. The concept of the apparatus being developed uses the low stretch geometry to simulate the conditions of the extraterrestrial environment through proper scaling of the sample dimensions to reduce the buoyant stretch in normal gravity. The apparatus uses controlled forced-air flow to augment the low stretch to levels which simulate Lunar or Martian gravity levels. In addition, the effect of imposed radiant heat flux on material flammability can be studied with the cone heater. After breadboard testing, the apparatus will be integrated into NASA's White Sands Test Facility's Atmosphere-Controlled Cone Calorimeter for evaluation as a new materials screening test method.
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Space nuclear power systems for extraterrestrial basing
International Nuclear Information System (INIS)
Lance, J.R.; Chi, J.W.H.
1989-01-01
Previous studies of nuclear and non-nuclear power systems for lunar bases are compared with recent studies by others. Power levels from tens of kW e for early base operation up to 2000 kW e for a self-sustaining base with a Closed Environment Life Support System (CELSS) are considered. Permanent lunar or Martian bases will require the use of multiple nuclear units connected to loads with a power transmission and distribution system analogous to earth-based electric utility systems. A methodology used for such systems is applied to the lunar base system to examine the effects of adding 100 kW e SP-100 class and/or larger nuclear units when a reliability criterion is imposed. The results show that resource and logistic burdens can be reduced by using 1000 kW e units early in the base growth scenario without compromising system reliability. Therefore, both technologies being developed in two current programs (SP-100 and NERVA Derivative Reactor (NDR) technology for space power) can be used effectively for extraterrestrial base power systems. Recent developments in NDR design that result in major reductions in reactor mass are also described. (author)
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Prolonged pregnancy: Methods, Causal Determinants and Outcome
DEFF Research Database (Denmark)
Olesen, Annette Wind
Summary Prolonged pregnancy, defined as a pregnancy with a gestational length of 294 days or more, is a frequent condition. It is associated with an increased risk of fetal and maternal complications. Little is known about the aetiology of prolonged pregnancy. The aims of the thesis were 1......) to study the incidence of prolonged pregnancy as a function of methods for determining gestational age; 2) to determine the risk of obstetrical and fetal complications in prolonged pregnancy; 3) to validate the self-reported gestational age in the National Birth Cohort; 4) to determine whether...... the risk of recurrence of prolonged pregnancy as a function of change in male partner and social conditions (IV). The National Birth Cohort provided data for the study on prenatal risk indicators of prolonged pregnancy in a follow-up design (V). The self-reported gestational ages from this database...
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Prolonged CT urography in duplex kidney.
Gong, Honghan; Gao, Lei; Dai, Xi-Jian; Zhou, Fuqing; Zhang, Ning; Zeng, Xianjun; Jiang, Jian; He, Laichang
2016-05-13
Duplex kidney is a common anomaly that is frequently associated with multiple complications. Typical computed tomography urography (CTU) includes four phases (unenhanced, arterial, parenchymal and excretory) and has been suggested to considerably aid in the duplex kidney diagnosi. Unfortunately, regarding duplex kidney with prolonged dilatation, the affected parenchyma and tortuous ureters demonstrate a lack of or delayed excretory opacification. We used prolonged-delay CTU, which consists of another prolonged-delay phase (1- to 72-h delay; mean delay: 24 h) to opacify the duplicated ureters and affected parenchyma. Seventeen patients (9 males and 8 females; age range: 2.5-56 y; mean age: 40.4 y) with duplex kidney were included in this study. Unenhanced scans did not find typical characteristics of duplex kidney, except for irregular perirenal morphology. Duplex kidney could not be confirmed on typical four-phase CTU, whereas it could be easily diagnosed in axial and CT-3D reconstruction using prolonged CTU (prolonged-delay phase). Between January 2005 and October 2010, in this review board-approved study (with waived informed consent), 17 patients (9 males and 8 females; age range: 2.5 ~ 56 y; mean age: 40.4 y) with suspicious duplex kidney underwent prolonged CTU to opacify the duplicated ureters and confirm the diagnosis. Our results suggest the validity of prolonged CTU to aid in the evaluation of the function of the affected parenchyma and in the demonstration of urinary tract malformations.
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Spacelab Life Science-1 Mission Onboard Photograph
1995-01-01
Spacelab Life Science -1 (SLS-1) was the first Spacelab mission dedicated solely to life sciences. The main purpose of the SLS-1 mission was to study the mechanisms, magnitudes, and time courses of certain physiological changes that occur during space flight, to investigate the consequences of the body's adaptation to microgravity and readjustment to Earth's gravity, and bring the benefits back home to Earth. The mission was designed to explore the responses of the heart, lungs, blood vessels, kidneys, and hormone-secreting glands to microgravity and related body fluid shifts; examine the causes of space motion sickness; and study changes in the muscles, bones, and cells. This photograph shows astronaut Rhea Seddon conducting an inflight study of the Cardiovascular Deconditioning experiment by breathing into the cardiovascular rebreathing unit. This experiment focused on the deconditioning of the heart and lungs and changes in cardiopulmonary function that occur upon return to Earth. By using noninvasive techniques of prolonged expiration and rebreathing, investigators can determine the amount of blood pumped out of the heart (cardiac output), the ease with which blood flows through all the vessels (total peripheral resistance), oxygen used and carbon dioxide released by the body, and lung function and volume changes. SLS-1 was launched aboard the Space Shuttle Orbiter Columbia (STS-40) on June 5, 1995.
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Binet, L.; Gourier, D.; Derenne, S.; Robert, F.; Ciofini, I.
2003-03-01
EPR of the insoluble organic matter (IOM) of three chondrites revealed heterogeneously spread radicals including diradicaloids. These features not observed in terrestrial kerogens appear as an extraterrestrial signature of the chondritic IOM.
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A Review of Extra-Terrestrial Mining Robot Concepts
Mueller, Robert P.; Van Susante, Paul J.
2011-01-01
Outer space contains a vast amount of resources that offer virtually unlimited wealth to the humans that can access and use them for commercial purposes. One of the key technologies for harvesting these resources is robotic mining of regolith, minerals, ices and metals. The harsh environment and vast distances create challenges that are handled best by robotic machines working in collaboration with human explorers. Humans will benefit from the resources that will be mined by robots. They will visit outposts and mining camps as required for exploration, commerce and scientific research, but a continuous presence is most likely to be provided by robotic mining machines that are remotely controlled by humans. There have been a variety of extra-terrestrial robotic mining concepts proposed over the last 100 years and this paper will attempt to summarize and review concepts in the public domain (government, industry and academia) to serve as an informational resource for future mining robot developers and operators. The challenges associated with these concepts will be discussed and feasibility will be assessed. Future needs associated with commercial efforts will also be investigated.
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Astrobiology: guidelines and future missions plan for the international community
French, L.; Miller, D.
The search for extra-terrestrial life has been going on ever since humans realized there was more to the Universe than just the Earth. These quests have taken many forms including, but not limited to: the quest for understanding the biological origins of life on Earth; the deployment of robotic probes to other planets to look for microbial life; the analysis of meteorites for chemical and fossil remnants of extra - terrestrial life; and the search of the radio spectrum for signs of extra-solar intelligence. These searches so far have yielded hints, but no unambiguous proof of life with origins from off Earth. The emerging field of astrobiology studies the origin, distribution, and future of life in the Universe. Technical advances and new, though not conclusive, evidence of extinct microbial life on Mars have created a new enthusiasm for astrobiology in many nations. However, the next steps to take are not clear, and should a positive result be returned, the follow-on missions are yet to be defined. This paper reports on the results of an eight-week study by the students of the International Space University during the summer of 2002. The study created a source book that can be used by mission designers and policy makers to chart the next steps in astrobiology. In particular, the study addresses the following questions:1.What is the full set of dimensions along which we can search forextra-terrestrial life?2.What activities are currently underway by the internationalcommunity along each of these dimensions?3.What are the most effective next steps that can be taken by theinternational space community in order to further this search (from a policy,sociological and mission point of view)?4.What are the proper steps for eliminating possible contaminationof the Earth's biosphere?5.What are the issues with planetary quarantine with regards tounwanted contamination of other biospheres with terrestrial organisms? Integrating all the considerations affecting the search for
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[Brain function recovery after prolonged posttraumatic coma].
Klimash, A V; Zhanaidarov, Z S
2016-01-01
To explore the characteristics of brain function recovery in patients after prolonged posttraumatic coma and with long-unconscious states. Eighty-seven patients after prolonged posttraumatic coma were followed-up for two years. An analysis of a clinical/neurological picture after a prolonged episode of coma was based on the dynamics of vital functions, neurological status and patient's reactions to external stimuli. Based on the dynamics of the clinical/neurological picture that shows the recovery of functions of the certain brain areas, three stages of brain function recovery after a prolonged episode of coma were singled out: brain stem areas, diencephalic areas and telencephalic areas. These functional/anatomic areas of brain function recovery after prolonged coma were compared to the present classifications.
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Papagiannis, M. D.
The conference presents papers on the history of the search for extraterrestrial life, the scientific rationale and methods used in the search for other planetary systems, the detection of distant planets with the Space Telescope, planetary searches using optical astrometric interferometers, and infrared spectral identification of complex organic molecules in interstellar grains. Also considered are universal protein ancestors from hydrogen cyanide and water, astronomical sources of polarized light and their role in determining molecular chirality on earth, the universal diagrams and life in the universe, the precambrian evolution of terrestrial life and a thermodynamic approach to the occurrance and appearance of galactic life forms. Papers are also presented on the Ohio Seti program, lunar reflections of terrestrial radio leakage, the multichannel spectrum analyzer, software implementation of detection algorithms for the MCSA, the Serendip II design, galactic colonization and competition in a young galactic disk, implications of ancient and future migrations, extraterrestrial intelligence, the inevitability and the possible structures of supercivilizations, planetary, interplanetary and interstellar organic matter, and universal aspects of biological evolution.
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[Pathophysiology of prolonged hypokinesia].
Kovalenko, E A
1976-01-01
Hypokinesia is an important problem in modern medicine. In the pathogenetic effect of prolonged hypokinesia the main etiological factor is diminished motor activity; of major importance are disorders in the energy and plastic metabolism which affect the muscle system; the contributing factors are cardiovascular deconditioning and orthostatic intolerance. This is attributed to a decreased oxygen supply and eliminated hydrostatic influences during a prolonged recumbency. Blood redistribution in the vascular bed is related to the Gauer-Henry reflex and subsequent changes in the fluid-electrolyte balance. Decreased load on the bone system induces changes in the protein-phosphate-calcium metabolism, diminished bone density and increased calcium content in the blood and urine. Changes in the calcium metabolism are systemic. The activity of the higher nervous system and reflex functions is lowered. Changes in the function of the autonomic nervous system which include a noticeable decline of its adaptive-trophic role as a result of the decrease of afferent and efferent impulsation are of great importance. Changes in the hormonal function involve a peculiar stress-reaction which develops at an early stage of hypokinesia as a response to an unusual situation. Prolonged hypokinesia may result in a disturbed function of the pituitary-adrenal system. It is assumed that prolonged hypokinesia may induce a specific disease of hypokinesia during which man cannot lead a normal mode of life and work.
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Zafar, R.
2017-12-01
The relationship between minerals and organics is an essential factor in comprehending the origin of life on extraterrestrial bodies. So far organic molecules have been detected on meteorites, comets, interstellar medium and interplanetary dust particles. While on Mars, organic molecules may also be present as indicated by the Sample Analysis at Mars (SAM) instrument suite on the Curiosity Rover in Martian sediments. Minerals including hydrated phyllosilicate, carbonate, and sulfate minerals have been confirmed in carbonaceous chondrites. The presence of phyllosilicate minerals on Mars has been indicated by in situ elemental analysis by the Viking Landers, remote sensing infrared observations and the presence of smectites in meteorites. Likewise, the presence of carbonate minerals on the surface of Mars has been indicated by both Phoenix Lander and Spirit Rover. Considering the fact that both mineral and organic matter are present on the surface of extraterrestrial bodies including Mars, a comprehensive work is required to understand the interaction of minerals with specific organic compounds. The adsorption of the organic molecule at water/mineral surface is a key process of concentrating organic molecules on the surface of minerals. Carboxylic acids are abundantly observed in extraterrestrial material such as meteorites and interstellar space. It is highly suspected that carboxylic acids are also present on Mars due to the average organic carbon infall rate of 108 kg/yr. Further aromatic organic acids have also been observed in carbonaceous chondrite meteorites. This work presents the adsorption of an aromatic carboxylic acid at the water/calcite interface and characterization of the products formed after adsorption via on-line pyrolysis. Adsorption and online pyrolysis results are used to gain insight into adsorbed aromatic organic acid-calcite interaction. Adsorption and online pyrolysis results are related to the interpretation of organic compounds identified
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Searching for Extraterrestrial Intelligence SETI Past, Present, and Future
Shuch, H Paul
2011-01-01
This book is a collection of essays written by the very scientists and engineers who have led, and continue to lead, the scientific quest known as SETI, the search for extraterrestrial intelligence. Divided into three parts, the first section, ‘The Spirit of SETI Past’, written by the surviving pioneers of this then emerging discipline, reviews the major projects undertaken during the first 50 years of SETI science and the results of that research. In the second section, ‘The Spirit of SETI Present’, the present-day science and technology is discussed in detail, providing the technical background to contemporary SETI instruments, experiments, and analytical techniques, including the processing of the received signals to extract potential alien communications. In the third and final section, ‘The Spirit of SETI Future’, the book looks ahead to the possible directions that SETI will take in the next 50 years, addressing such important topics as interstellar message construction, the risks and assump...
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International Nuclear Information System (INIS)
Wright, J. T.; Griffith, R. L.; Sigurdsson, S.; Povich, M. S.; Mullan, B.
2014-01-01
We describe the framework and strategy of the Ĝ infrared search for extraterrestrial civilizations with large energy supplies, which will use the wide-field infrared surveys of WISE and Spitzer to search for these civilizations' waste heat. We develop a formalism for translating mid-infrared photometry into quantitative upper limits on extraterrestrial energy supplies. We discuss the likely sources of false positives, how dust can and will contaminate our search, and prospects for distinguishing dust from alien waste heat. We argue that galaxy-spanning civilizations may be easier to distinguish from natural sources than circumstellar civilizations (i.e., Dyson spheres), although GAIA will significantly improve our capability to identify the latter. We present a zeroth order null result of our search based on the WISE all-sky catalog: we show, for the first time, that Kardashev Type III civilizations (as Kardashev originally defined them) are very rare in the local universe. More sophisticated searches can extend our methodology to smaller waste heat luminosities, and potentially entirely rule out (or detect) both Kardashev Type III civilizations and new physics that allows for unlimited 'free' energy generation.
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Energy Technology Data Exchange (ETDEWEB)
Wright, J. T.; Griffith, R. L.; Sigurdsson, S. [Department of Astronomy and Astrophysics, 525 Davey Lab, The Pennsylvania State University, University Park, PA, 16802 (United States); Povich, M. S. [Department of Physics and Astronomy, California State Polytechnic University, Pomona, 3801 West Temple Avenue, Pomona, CA 91768 (United States); Mullan, B. [Blue Marble Space Institution of Science, P.O. Box 85561, Seattle, WA 98145-1561 (United States)
2014-09-01
We describe the framework and strategy of the Ĝ infrared search for extraterrestrial civilizations with large energy supplies, which will use the wide-field infrared surveys of WISE and Spitzer to search for these civilizations' waste heat. We develop a formalism for translating mid-infrared photometry into quantitative upper limits on extraterrestrial energy supplies. We discuss the likely sources of false positives, how dust can and will contaminate our search, and prospects for distinguishing dust from alien waste heat. We argue that galaxy-spanning civilizations may be easier to distinguish from natural sources than circumstellar civilizations (i.e., Dyson spheres), although GAIA will significantly improve our capability to identify the latter. We present a zeroth order null result of our search based on the WISE all-sky catalog: we show, for the first time, that Kardashev Type III civilizations (as Kardashev originally defined them) are very rare in the local universe. More sophisticated searches can extend our methodology to smaller waste heat luminosities, and potentially entirely rule out (or detect) both Kardashev Type III civilizations and new physics that allows for unlimited 'free' energy generation.
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Wright, J. T.; Griffith, R. L.; Sigurdsson, S.; Povich, M. S.; Mullan, B.
2014-09-01
We describe the framework and strategy of the Ĝ infrared search for extraterrestrial civilizations with large energy supplies, which will use the wide-field infrared surveys of WISE and Spitzer to search for these civilizations' waste heat. We develop a formalism for translating mid-infrared photometry into quantitative upper limits on extraterrestrial energy supplies. We discuss the likely sources of false positives, how dust can and will contaminate our search, and prospects for distinguishing dust from alien waste heat. We argue that galaxy-spanning civilizations may be easier to distinguish from natural sources than circumstellar civilizations (i.e., Dyson spheres), although GAIA will significantly improve our capability to identify the latter. We present a zeroth order null result of our search based on the WISE all-sky catalog: we show, for the first time, that Kardashev Type III civilizations (as Kardashev originally defined them) are very rare in the local universe. More sophisticated searches can extend our methodology to smaller waste heat luminosities, and potentially entirely rule out (or detect) both Kardashev Type III civilizations and new physics that allows for unlimited "free" energy generation.
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QT Prolongation due to Graves’ Disease
Directory of Open Access Journals (Sweden)
Zain Kulairi
2017-01-01
Full Text Available Hyperthyroidism is a highly prevalent disease affecting over 4 million people in the US. The disease is associated with many cardiac complications including atrial fibrillation and also less commonly with ventricular tachycardia and fibrillation. Many cardiac pathologies have been extensively studied; however, the relationship between hyperthyroidism and rate of ventricular repolarization manifesting as a prolonged QTc interval is not well known. Prolonged QTc interval regardless of thyroid status is a risk factor for cardiovascular mortality and life-threatening ventricular arrhythmia. The mechanism regarding the prolongation of the QT interval in a hyperthyroid patient has not been extensively investigated although its clinical implications are relevant. Herein, we describe a case of prolonged QTc in a patient who presented with signs of hyperthyroidism that was corrected with return to euthyroid status.
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Wright, J. T.; Mullan, B.; Sigurdsson, S.; Povich, M. S.
2014-09-01
We motivate the Ĝ infrared search for extraterrestrial civilizations with large energy supplies. We discuss some philosophical difficulties of the search for extraterrestrial intelligence (SETI), and how communication SETI circumvents them. We review "Dysonian SETI," the search for artifacts of alien civilizations, and find that it is highly complementary to traditional communication SETI; the two together might succeed where either one alone has not. We discuss the argument of Hart that spacefaring life in the Milky Way should be either galaxy-spanning or non-existent, and examine a portion of his argument that we call the "monocultural fallacy." We discuss some rebuttals to Hart that invoke sustainability and predict long Galaxy colonization timescales. We find that the maximum Galaxy colonization timescale is actually much shorter than previous work has found (energy supplies and argue that detectably large energy supplies can plausibly be expected to exist because life has the potential for exponential growth until checked by resources or other limitations, and intelligence implies the ability to overcome such limitations. As such, if Hart's thesis is correct, then searches for large alien civilizations in other galaxies may be fruitful; if it is incorrect, then searches for civilizations within the Milky Way are more likely to succeed than Hart argued. We review some past Dysonian SETI efforts and discuss the promise of new mid-infrared surveys, such as that of WISE.
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Exhaustion from prolonged gambling
Directory of Open Access Journals (Sweden)
Fatimah Lateef
2013-01-01
Full Text Available Complaints of fatigue and physical exhaustion are frequently seen in the acute medical setting, especially amongst athletes, army recruits and persons involved in strenuous and exertional physical activities. Stress-induced exhaustion, on the other hand, is less often seen, but can present with very similar symptoms to physical exhaustion. Recently, three patients were seen at the Department of Emergency Medicine, presenting with exhaustion from prolonged involvement in gambling activities. The cases serve to highlight some of the physical consequences of prolonged gambling.
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PHILOSOPHICAL-ANTROPOLOGICAL ASPECTS OF A PROBLEM OF SEARCH EXTRA-TERRESTRIAL OF CIVILIZATIONS
Directory of Open Access Journals (Sweden)
A. T. Tshedrin
2013-09-01
Full Text Available Purpose. The fears express, that «METI-projects», which testify to existence of mankind as technicalgeneous of a civilization for highly advanced ETC of a Galaxy, can have the extremely negative consequences, and «SETI-projects» and received radiosignals can become the information weapon aggressive ETC. The analysis of these fears as complete sociocultural of a phenomenon, them philosophical-anthropological of measurement, sociocultural of the basis, the forms of their display are the purpose of clause. Methodology. Author used the social-communicative approach, methods of system and cluster analyses. Scientific innovation. Are opened philosophical-anthropological of measurement of a problem of life extra-terrestrial intelligents (ETI, the factors of statement of a problem of contacts with ETC in the modern form connected with spacing of scientific and technical activity of mankind, influence of processes globalization on philosophical-anthropological aspects of a problem ETC, connected with changes in the fundamental relation «the Man - World» are investigated. These processes conduct to growth of fears concerning unpredictable intervention in terrestrial sociocultural system of alien reason. The persuasive fears, connected with possible consequences of contacts with ETC, take the form of hypotheses rather extra-terrestrial of artificial intelligence (ETAI as potential subject of space contact. The positive and negative scripts of dialogue with ETAI, problem «of high quality of a signal» and «SETI-hacker», connected with ETAI as by the subject of space dialogue are considered. Conclusions. The further development of a problem of search ETC and establishment of contacts with it will be connected, on the one hand to success in overcoming civilization of impasse, in which there was a mankind on a boundary ХХ – ХХI of centuries, and with another - deepening of revolution in cosmology, progress of observant astronomy, philosophical
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Engel, M. H.; Macko, S. A.
2003-04-01
Life on Earth consists of orderly arrangements of several key types of organic compounds (amino acids, sugars, fatty acids, nucleic bases) that are the building blocks of proteins, carbohydrates, lipids and nucleotides. Subsequent to death, macromolecules are commonly broken down to their molecular constituents or other similar scale components. Thus, in ancient terrestrial and extraterrestrial materials, it is far more likely to expect the presence of simple compounds such as amino acids rather than the proteins from which they were possibly derived. Given that amino acids, for example, are common components of all extinct and extant organisms, the challenge has been to develop methods for distinguishing their sources. Stable isotopes are powerful probes for determining the origins of organic matter. Amino acid constituents of all organisms on Earth exhibit characteristic stable isotope compositions owing to fractionations associated with their biosynthesis. These fractionations are distinct from those observed for amino acids formed by abiotic processes. Thus it should be possible to use isotopes as probes for determining whether amino acids in ancient rocks on Earth are biotic or abiotic, based on their relative isotopic compositions. Also, owing to differences in the isotope compositions of precursors, amino acids in extraterrestrial materials such as carbonaceous meteorites are moderately to substantially enriched in the heavy isotopes of C, N and H relative to terrestrial amino acids. Assuming that the isotope compositions of the gaseous components of, for example, the Martian atmosphere were distinct from Earth at such time when organic molecules may have formed, it should be possible to distinguish these components from terrestrial contaminants by determining their isotope compositions and/or those of their respective enantiomers. Also, if life as we know it existed on another planet such as Mars, fractionations characteristic of biosynthesis should be
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9. Nuclear power plant service life prolongation
International Nuclear Information System (INIS)
Evropin, S.V.
1998-01-01
The problem of prolongation of nuclear power plant service life duration is discussed. A schematic diagram of the program developed in the course of activities dealing with NPP service time prolongation is shown and analyzed in details. It is shown that the basic moment when determining the strategy for NPP service time prolongation is the positive confirmation of the agreement between the NPP safety provisions and modern safety requirements. The other very important aspect of the problem is engineering substantiation of the measures assuring the reactor operation prolongation. The conclusion is made that available methods of recovering reactor materials properties, main components repair and replacement, the modern techniques for nondestructive testing of metals and NPP pipelines, as well as the developed approaches to reactor facility safety improvements make the prolongation of the Russian NPP service lifetimes possible from engineering viewpoint and economically desirable
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Laboratory for Extraterrestrial Physics
Vondrak, Richard R. (Technical Monitor)
2001-01-01
The NASA Goddard Space Flight Center (GSFC) Laboratory for Extraterrestrial Physics (LEP) performs experimental and theoretical research on the heliosphere, the interstellar medium, and the magnetospheres and upper atmospheres of the planets, including Earth. LEP space scientists investigate the structure and dynamics of the magnetospheres of the planets including Earth. Their research programs encompass the magnetic fields intrinsic to many planetary bodies as well as their charged-particle environments and plasma-wave emissions. The LEP also conducts research into the nature of planetary ionospheres and their coupling to both the upper atmospheres and their magnetospheres. Finally, the LEP carries out a broad-based research program in heliospheric physics covering the origins of the solar wind, its propagation outward through the solar system all the way to its termination where it encounters the local interstellar medium. Special emphasis is placed on the study of solar coronal mass ejections (CME's), shock waves, and the structure and properties of the fast and slow solar wind. LEP planetary scientists study the chemistry and physics of planetary stratospheres and tropospheres and of solar system bodies including meteorites, asteroids, comets, and planets. The LEP conducts a focused program in astronomy, particularly in the infrared and in short as well as very long radio wavelengths. We also perform an extensive program of laboratory research, including spectroscopy and physical chemistry related to astronomical objects. The Laboratory proposes, develops, fabricates, and integrates experiments on Earth-orbiting, planetary, and heliospheric spacecraft to measure the characteristics of planetary atmospheres and magnetic fields, and electromagnetic fields and plasmas in space. We design and develop spectrometric instrumentation for continuum and spectral line observations in the x-ray, gamma-ray, infrared, and radio regimes; these are flown on spacecraft to study
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The Implications of the Discovery of Extraterrestrial Life for Religion and Theology
Peters, Ted
2012-05-01
This paper asks about the future of religion: (1) Will confirmation of ETI cause terrestrial religion to collapse? "No" is the answer based upon a summary of the "Peters ETI Religious Crisis Survey." Then three questions are posed to the astrotheologian: (2) What is the scope of God's creation? (3) What can we expect when we encounter ETI? (4) Will contact with more advanced ETI diminish human dignity? The paper's thesis is that contact with extraterrestrial intelligence will expand the existing Christian vision that all of creation — including the 13.7 billion year history of the universe replete with all of God's creatures — is the gift of a loving and gracious God.
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Preliminary limits on the flux of muon neutrinos from extraterrestrial point sources
International Nuclear Information System (INIS)
Bionta, R.M.; Blewitt, G.; Bratton, C.B.
1985-01-01
We present the arrival directions of 117 upward-going muon events collected with the IMB proton lifetime detector during 317 days of live detector operation. The rate of upward-going muons observed in our detector was found to be consistent with the rate expected from atmospheric neutrino production. The upper limit on the total flux of extraterrestrial neutrinos >1 GeV is 2 -sec. Using our data and a Monte Carlo simulation of high energy muon production in the earth surrounding the detector, we place limits on the flux of neutrinos from a point source in the Vela X-2 system of 2 -sec with E > 1 GeV. 6 refs., 5 figs
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Safety information on QT-interval prolongation
DEFF Research Database (Denmark)
Warnier, Miriam J; Holtkamp, Frank A; Rutten, Frans H
2014-01-01
Prolongation of the QT interval can predispose to fatal ventricular arrhythmias. Differences in QT-labeling language can result in miscommunication and suboptimal risk mitigation. We systematically compared the phraseology used to communicate on QT-prolonging properties of 144 drugs newly approve...
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Genetic influence on prolonged gestation
DEFF Research Database (Denmark)
Laursen, Maja; Bille, Camilla; Olesen, Annette Wind
2004-01-01
OBJECTIVE: The purpose of this study was to test a possible genetic component to prolonged gestation. STUDY DESIGN: The gestational duration of single, first pregnancies by both female and male twins was obtained by linking the Danish Twin Registry, The Danish Civil Registration System, and the D...... factors. CONCLUSION: Maternal genes influence prolonged gestation. However, a substantial paternal genetic influence through the fetus was not found....
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Bertka, Constance M.
The question of whether or not extraterrestrial life exists and its potential impact for religions, especially Christianity, is an ancient one addressed in numerous historical publications. The contemporary discussion has been dominated by a few notable scientists from the SETI and astrobiology communities, and by a few Christian theologians active in the science and religion field. This discussion amounts to scientists outside of the faith tradition predicting the demise of Christianity if extraterrestrial intelligent life is discovered and theologians within the tradition predicting the enrichment and reformulation of Christian doctrine. Missing from this discussion is insight drawn more broadly from the science and religion field and from the sociology of religion. A consideration of how possibilities for relating science and religion are reflected in the US public's varied acceptance of the theory of evolution; the growth of Christianity in the Global South; and a revised theory of secularization which inversely correlates religiosity to existential security, gives credence to the proposal that the response from those outside of academia would be much more varied and uncertain.
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Webb, Stephen
2015-01-01
Given the fact that there are perhaps 400 billion stars in our Galaxy alone, and perhaps 400 billion galaxies in the Universe, it stands to reason that somewhere out there, in the 14-billion-year-old cosmos, there is or once was a civilization at least as advanced as our own. The sheer enormity of the numbers almost demands that we accept the truth of this hypothesis. Why, then, have we encountered no evidence, no messages, no artifacts of these extraterrestrials? In this second, significantly revised and expanded edition of his widely popular book, Webb discusses in detail the (for now!) 75 most cogent and intriguing solutions to Fermi's famous paradox: If the numbers strongly point to the existence of extraterrestrial civilizations, why have we found no evidence of them?
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The Ĝ Infrared Search for Extraterrestrial Civilizations with Large Energy Supplies
Wright, Jason Thomas; Povich, Matthew; Griffith, Roger; Maldonado, Jessica; Sigurdsson, Steinn; Star Cartier, Kimberly
2015-08-01
The WISE and Spitzer large-area surveys of the mid-infrared sky bring a new opportunity to search for evidence of the energy supplies of very large extraterrestrial civilizations. If these energy supplies rival the output of a civilization's parent star (Kardashev Type II), or if a galaxy-spanning supercivilization's use rivals that of the total galactic luminosity (Type III), they would be detectable as anomolously mid-infrared-bright stars and galaxies, respectively. We have already performed the first search for this emission from Type III civilizations using the WISE all-sky survey, and put the first upper limits on them in the local universe, and discuss ways to improve on these limits. We also discuss some detectable forms of and limits on Type II civilizations in the Mliky Way.
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Fernandez-Moran, H.; Pritzker, A. N.
1974-01-01
Improved instrumentation and preparation techniques for high resolution, high voltage cryo-electron microscopic and diffraction studies on terrestrial and extraterrestrial specimens are reported. Computer correlated ultrastructural and biochemical work on hydrated and dried cell membranes and related biological systems provided information on membrane organization, ice crystal formation and ordered water, RNA virus linked to cancer, lunar rock samples, and organometallic superconducting compounds. Apollo 11, 12, 14, and 15 specimens were analyzed
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Discovery of ETI: Terrestrial and extraterrestrial legal implications
Fasan, Ernst
TheLegalSituationonEarth: The following international legal regulations seem to apply to the search for and the eventual detection of ETI: a) The "Space Treaty" of Oct. 10, 1967; b) The Liability Convention of Oct. 9, 1973; c) The Moon Agreement of Dec. 5, 1979; d) The International Telecommunication Convention. LegalRelationswithExtraterrestrials: We may expect the following characteristics of ETI: 1. life in the sense of influencing the environment by selection from more than one possibility; 2. intelligence in the sense of self-realization of free will; 3. existence in three dimensional space and a will to live. With this we can expect that each race in the universe may have the following interests regarding its own race: a) to preserve and continue its own life; b) to protect this life from damage and intrusion; c) possibly to expand the realms of its living space. Therefore, if we decide to "answer" ETI, we may want to transmit such legal-philosophical principles: 1. the principle of nonviolation; 2. the principle of equality; 3. the principle to recognize the will to live and the living space of any intelligent race.
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Risk factors for QTc interval prolongation
Heemskerk, Charlotte P.M.; Pereboom, Marieke; van Stralen, Karlijn; Berger, Florine A.; van den Bemt, Patricia M.L.A.; Kuijper, Aaf F.M.; van der Hoeven, Ruud T M; Mantel-Teeuwisse, Aukje K.; Becker, Matthijs L
2018-01-01
Purpose: Prolongation of the QTc interval may result in Torsade de Pointes, a ventricular arrhythmia. Numerous risk factors for QTc interval prolongation have been described, including the use of certain drugs. In clinical practice, there is much debate about the management of the risks involved. In
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Directory of Open Access Journals (Sweden)
Li Dawei
2014-08-01
Full Text Available Servicing is applied periodically in practice with the aim of restoring the system state and prolonging the lifetime. It is generally seen as an imperfect maintenance action which has a chief influence on the maintenance strategy. In order to model the maintenance effect of servicing, this study analyzes the deterioration characteristics of system under scheduled servicing. And then the deterioration model is established from the failure mechanism by compound Poisson process. On the basis of the system damage value and failure mechanism, the failure rate refresh factor is proposed to describe the maintenance effect of servicing. A maintenance strategy is developed which combines the benefits of scheduled servicing and preventive maintenance. Then the optimization model is given to determine the optimal servicing period and preventive maintenance time, with an objective to minimize the system expected life-cycle cost per unit time and a constraint on system survival probability for the duration of mission time. Subject to mission time, it can control the ability of accomplishing the mission at any time so as to ensure the high dependability. An example of water pump rotor relating to scheduled servicing is introduced to illustrate the failure rate refresh factor and the proposed maintenance strategy. Compared with traditional methods, the numerical results show that the failure rate refresh factor can describe the maintenance effect of servicing more intuitively and objectively. It also demonstrates that this maintenance strategy can prolong the lifetime, reduce the total lifetime maintenance cost and guarantee the dependability of system.
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Crawford, Ian A.
2017-01-01
Astrobiology is usually defined as the study of the origin, evolution, distribution, and future of life in the universe. As such it is inherently interdisciplinary and cannot help but engender a worldview infused by cosmic and evolutionary perspectives. Both these attributes of the study of astrobiology are, and will increasingly prove to be, beneficial to society regardless of whether extraterrestrial life is discovered or not.
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Crawford, I. A.
2018-01-01
Astrobiology is usually defined as the study of the origin, evolution, distribution and future of life in the Universe. As such it is inherently interdisciplinary and cannot help but engender a worldview infused by cosmic and evolutionary perspectives. Both these attributes of the study of astrobiology are, and will increasingly prove to be, beneficial to society regardless of whether extraterrestrial life is discovered or not.
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Prolongation of islet allograft survival
International Nuclear Information System (INIS)
Lacy, P.E.; Davie, J.M.; Finke, E.H.; Scharp, D.W.
1979-01-01
Pretreatment of donor rats with irradiation and silica followed by in vitro culture of the islets for 1 to 2 days prolonged survival of allografts across a minor histocompatibility barrier if hand-picked, clean islets were used for transplantation. Pretreatment of donor rats with irradiation and silica in conjunction with a single injection of antilymphocyte serum (ALS) into the recipient produced a prolongation of survival of hand-picked islets transplanted across a major histocompatibility barrier
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Prolonged pain and disability are common after rib fractures.
Fabricant, Loic; Ham, Bruce; Mullins, Richard; Mayberry, John
2013-05-01
The contribution of rib fractures to prolonged pain and disability may be underappreciated and undertreated. Clinicians are traditionally taught that the pain and disability of rib fractures resolves in 6 to 8 weeks. This study was a prospective observation of 203 patients with rib fractures at a level 1 trauma center. Chest wall pain was evaluated by the McGill Pain Questionnaire (MPQ) pain rating index (PRI) and present pain intensity (PPI). Prolonged pain was defined as a PRI of 8 or more at 2 months after injury. Prolonged disability was defined as a decrease in 1 or more levels of work or functional status at 2 months after injury. Predictors of prolonged pain and disability were determined by multivariate analysis. One hundred forty-five male patients and 58 female patients with a mean injury severity score (ISS) of 20 (range, 1 to 59) had a mean of 5.4 rib fractures (range, 1 to 29). Forty-four (22%) patients had bilateral fractures, 15 (7%) had flail chest, and 92 (45%) had associated injury. One hundred eighty-seven patients were followed 2 months or more. One hundred ten (59%) patients had prolonged chest wall pain and 142 (76%) had prolonged disability. Among 111 patients with isolated rib fractures, 67 (64%) had prolonged chest wall pain and 69 (66%) had prolonged disability. MPQ PPI was predictive of prolonged pain (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.4 to 2.5), and prolonged disability (OR, 2.2; 95% CI, 1.5 to 3.4). The presence of significant associated injuries was predictive of prolonged disability (OR, 5.9; 95% CI, 1.4 to 29). Prolonged chest wall pain is common, and the contribution of rib fractures to disability is greater than traditionally expected. Further investigation into more effective therapies that prevent prolonged pain and disability after rib fractures is needed. Copyright © 2013 Elsevier Inc. All rights reserved.
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Dasgupta, B.
2016-12-01
The earth's crust is a geodynamic realm, which is constantly evolving. Due to its dynamic nature, the crust is constantly being subjected to remodelling. The earth's crustal response to stress is a result of isostatic compensation. The crust is also a living proof of yesteryears' dynamics. Extra-terrestrial agents of deformation refers to meteorites, asteroids etc. These are catastrophic events that influence a larger area (considering larger impact bodies). They effect the crust from outside, hence leave behind very specific structural signatures.Consider an extra-terrestrial object impacting the earth's crust. The problem can be broken down into 3 parts: Pre Impact (kinematics of the object and nature of surface of impact); Syn Impact (dissipation of energy and formation of crater); and Post Impact (structural response, geophysical anomalies and effect on biota)Upon impact, the projectile penetrates the earth's crust to a depth of twice its diameter. Shock waves generated due impact propagate in all possible directions. The reflected waves cause complete melting and vaporization of the impact body. At the same time, increased internal energy of the system melts the target rock. Depending on the thickness and density of crustal matter, its' interaction with the mantle is determined. Data collection from such impact sites is the first step towards its theoretical modeling. Integrating geophysical (seismic, magnetic), paleomagnetic, geochemical and geo-chronological data one can determine the kinematic parameters that governed the event. A working model that illustrates the crustal responses to extraterrestrial stress of extreme magnitude cannot be qualitative. Hence the most fundamental thing at this point is quantification of these parameters. The variables form a `mass-energy equation', a simple theorem in Classical Physics. This project is directed to give the equation its shape. The equation will be the foundation on which the simulation model will rest. Mass
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Prolonged delirium misdiagnosed as a mood disorder.
Cao, Fei; Salem, Haitham; Nagpal, Caesa; Teixeira, Antonio L
2017-01-01
Delirium can be conceptualized as an acute decline in cognitive function that typically lasts from hours to a few days. Prolonged delirium can also affect patients with multiple predisposing and/or precipitating factors. In clinical practice, prolonged delirium is often unrecognized, and can be misdiagnosed as other psychiatric disorders. We describe a case of a 59-year-old male presenting with behavioral and cognitive symptoms that was first misdiagnosed as a mood disorder in a general hospital setting. After prolonged delirium due to multiple factors was confirmed, the patient was treated accordingly with symptomatic management. He evolved with progressive improvement of his clinical status. Early diagnosis and management of prolonged delirium are important to improve patient prognosis and avoid iatrogenic measures.
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The quest for extraterrestrial life: what about the viruses?
Griffin, Dale Warren
2013-01-01
Recently, viruses have been recognized as the most numerous entities and the primary drivers of evolution on Earth. Historically, viruses have been mostly ignored in the field of astrobiology due to the view that they are not alive in the classical sense and if encountered would not present risk due to their host-specific nature. What we currently know of viruses is that we are most likely to encounter them on other life-bearing planets; that while some are exquisitely host-specific, many viruses can utilize hundreds of different host species; that viruses are known to exist in our planet's most extreme environments; and that while many do not survive long outside their hosts, some can survive for extended periods, especially in the cold. In our quest for extraterrestrial life, we should be looking for viruses; and while any encountered may pose no risk, the possibility of an encounter with a virus capable of accessing multiple cell types exists, and any prospective contact with such an organism should be treated accordingly.
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Czech Academy of Sciences Publication Activity Database
Vondrák, D.; Kletetschka, G.; Hrubá, J.; Nábělek, L.; Procházka, V.; Svitavská-Svobodová, Helena; Bobek, Přemysl; Hořická, Zuzana; Kadlec, Jaroslav; Takáč, M.; Stuchlík, Evžen
2017-01-01
Roč. 52, S1 (2017), A373-A373, č. článku 6230. ISSN 1086-9379. [Annual Meeting of the Meteoritical Society /80./. 23.07.2017-28.07.2017, Santa Fe] R&D Projects: GA ČR(CZ) GA17-05935S Institutional support: RVO:67985939 ; RVO:60077344 ; RVO:67985530 Keywords : Younger Dryas * Extraterrestrial Impact * Central Europe Subject RIV: DG - Athmosphere Sciences, Meteorology; DA - Hydrology ; Limnology (BC-A); DE - Earth Magnetism, Geodesy, Geography (GFU-E) OBOR OECD: Plant sciences, botany
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QT interval prolongation associated with sibutramine treatment
Harrison-Woolrych, Mira; Clark, David W J; Hill, Geraldine R; Rees, Mark I; Skinner, Jonathan R
2006-01-01
Aims To investigate a possible association of sibutramine with QT interval prolongation. Methods Post-marketing surveillance using prescription event monitoring in the New Zealand Intensive Medicines Monitoring Programme (IMMP) identified a case of QT prolongation and associated cardiac arrest in a patient taking sibutramine for 25 days. This patient was further investigated, including genotyping for long QT syndrome. Other IMMP case reports suggesting arrhythmias associated with sibutramine were assessed and further reports were obtained from the World Health Organisation (WHO) adverse drug reactions database. Results The index case displayed a novel mutation in a cardiac potassium channel subunit gene, KCNQ1, which is likely to prolong cardiac membrane depolarization and increase susceptibility to long QT intervals. Assessment of further IMMP reports identified five additional patients who experienced palpitations associated with syncope or presyncopal symptoms, one of whom had a QTc at the upper limit of normal. Assessment of reports from the WHO database identified three reports of QT prolongation and one fatal case of torsade de pointes in a patient also taking cisapride. Conclusions This case series suggests that sibutramine may be associated with QT prolongation and related dysrhythmias. Further studies are required, but in the meantime we would recommend that sibutramine should be avoided in patients with long QT syndrome and in patients taking other medicines that may prolong the QT interval. PMID:16542208
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Power Management Strategy by Enhancing the Mission Profile Configuration of Solar-Powered Aircraft
Directory of Open Access Journals (Sweden)
Parvathy Rajendran
2016-01-01
Full Text Available Solar energy offers solar-powered unmanned aerial vehicle (UAV the possibility of unlimited endurance. Some researchers have developed techniques to achieve perpetual flight by maximizing the power from the sun and by flying in accordance with its azimuth angles. However, flying in a path that follows the sun consumes more energy to sustain level flight. This study optimizes the overall power ratio by adopting the mission profile configuration of optimal solar energy exploitation. Extensive simulation is conducted to optimize and restructure the mission profile phases of UAV and to determine the optimal phase definition of the start, ascent, and descent periods, thereby maximizing the energy from the sun. In addition, a vertical cylindrical flight trajectory instead of maximizing the solar inclination angle has been adopted. This approach improves the net power ratio by 30.84% compared with other techniques. As a result, the battery weight may be massively reduced by 75.23%. In conclusion, the proposed mission profile configuration with the optimal power ratio of the trajectory of the path planning effectively prolongs UAV operation.
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New insights in the bacterial spore resistance to extreme terrestrial and extraterrestrial factors
Moeller, Ralf; Horneck, Gerda; Reitz, Guenther
Based on their unique resistance to various space parameters, Bacillus endospores are one of the model systems used for astrobiological studies. The extremely high resistance of bacterial endospores to environmental stress factors has intrigued researchers since long time and many characteristic spore features, especially those involved in the protection of spore DNA, have already been uncovered. The disclosure of the complete genomic sequence of Bacillus subtilis 168, one of the often used astrobiological model system, and the rapid development of tran-scriptional microarray techniques have opened new opportunities of gaining further insights in the enigma of spore resistance. Spores of B. subtilis were exposed to various extreme ter-restrial and extraterrestrial stressors to reach a better understanding of the DNA protection and repair strategies, which them to cope with the induced DNA damage. Following physical stress factors of environmental importance -either on Earth or in space -were selected for this thesis: (i) mono-and polychromatic UV radiation, (ii) ionizing radiation, (iii) exposure to ultrahigh vacuum; and (iv) high shock pressures simulating meteorite impacts. To reach a most comprehensive understanding of spore resistance to those harsh terrestrial or simulated extraterrestrial conditions, a standardized experimental protocol of the preparation and ana-lyzing methods was established including the determination of the following spore responses: (i) survival, (ii) induced mutations, (iii) DNA damage, (iv) role of different repair pathways by use of a set of repair deficient mutants, and (v) transcriptional responses during spore germi-nation by use of genome-wide transcriptome analyses and confirmation by RT-PCR. From this comprehensive set of data on spore resistance to a variety of environmental stress parameters a model of a "built-in" transcriptional program of bacterial spores in response to DNA damaging treatments to ensure DNA restoration
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Licence prolongations of US nuclear power plants
International Nuclear Information System (INIS)
2004-04-01
Licences of US nuclear reactors were initially attributed for a 40 years duration. However, the vast majority of the reactors can benefit of a licence prolongation for a period of 20 years maximum. This article recalls first the procedure to follow for the licence prolongation demands (safety analysis, components aging, environmental impact statement), and then it makes a status of the accepted prolongations, of the demands under examination, and of the demands that should be presented in the next 5 years. (J.S.)
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Alequin, W.; Barragan, A.; Carro, M.; Garcia, F.; Gonzalez, I.; Mercado, J. A.; Negron, N.; Lopez, D.; Rivera, L. A.; Rivera, M.
1990-01-01
During 1988 to 1989 the NASA/USRA Advanced Design Program sponsored research and design efforts aimed at developing habitability criteria and at defining a habitability concept as a useful tool in understanding and evaluating dwellings for prolonged stays in extraterrestrial space. The Circulating Auto sufficient Mars-Earth Luxurious Orbital Transport (CAMELOT) was studied as a case in which the students would try to enhance the quality of life of the inhabitants by applying architectural design methodology. The study proposed 14 habitability criteria considered necessary to fulfill the defined habitability concept, which is that state of equilibrium that results from the interaction between components of the Individual Architecture Mission Complex, which allows a person to sustain physiological homeostatis, adequate performance, and acceptable social relationships. Architecture, design development, refinements and revisions to improve the quality of life, new insights on artificial gravity, form and constitution problems, and the final design concept are covered.
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Measuring the effect of an astrobiology course on student optimism regarding extraterrestrial life
Morgan, David L.
2017-07-01
Students in an introductory undergraduate Astrobiology course were given a pre/post-test based on the Drake Equation in an attempt to measure changes in their perceptions regarding the prevalence of life in the Galaxy after taking the course. The results indicated that, after taking the course, the students were considerably more optimistic, by a 2 to 1 margin or more, about the prospect of habitable planets, the origin of life, and the evolution of intelligence in other planetary systems. The results suggest that, while it may not be the explicit goal of an astrobiology course to change student beliefs about the abundance or rarity of extraterrestrial life, such changes in opinion can and do occur.
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STS-61 mission director's post-mission report
Newman, Ronald L.
1995-01-01
To ensure the success of the complex Hubble Space Telescope servicing mission, STS-61, NASA established a number of independent review groups to assess management, design, planning, and preparation for the mission. One of the resulting recommendations for mission success was that an overall Mission Director be appointed to coordinate management activities of the Space Shuttle and Hubble programs and to consolidate results of the team reviews and expedite responses to recommendations. This report presents pre-mission events important to the experience base of mission management, with related Mission Director's recommendations following the event(s) to which they apply. All Mission Director's recommendations are presented collectively in an appendix. Other appendixes contain recommendations from the various review groups, including Payload Officers, the JSC Extravehicular Activity (EVA) Section, JSC EVA Management Office, JSC Crew and Thermal Systems Division, and the STS-61 crew itself. This report also lists mission events in chronological order and includes as an appendix a post-mission summary by the lead Payload Deployment and Retrieval System Officer. Recommendations range from those pertaining to specific component use or operating techniques to those for improved management, review, planning, and safety procedures.
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Burton, Aaron S.; Elsila, Jamie E.; Hein, Jason E.; Glavin, Daniel P.; Dworkin, Jason P.
2013-01-01
Carbonaceous chondrites contain numerous indigenous organic compounds and could have been an important source of prebiotic compounds required for the origin of life on Earth or elsewhere. Extraterrestrial amino acids have been reported in five of the eight groups of carbonaceous chondrites and are most abundant in CI, CM, and CR chondritesbut are also present in the more thermally altered CV and CO chondrites. We report the abundance, distribution, and enantiomeric and isotopic compositions of simple primary amino acids in six metal-rich CH and CB carbonaceous chondrites that have not previously been investigated for amino acids: Allan Hills (ALH) 85085 (CH3), Pecora Escarpment(PCA) 91467 (CH3), Patuxent Range (PAT) 91546 (CH3), MacAlpine Hills (MAC) 02675(CBb), Miller Range (MIL) 05082 (CB), and Miller Range (MIL) 07411 (CB). Amino acid abundances and carbon isotopic values were obtained by using both liquid chromatography time-of-flight mass spectrometry and fluorescence, and gas chromatography isotope ratiomass spectrometry. The (delta D, delta C-13, delta N-15) ratios of multiple amino acids fall outside of the terrestrial range and support their extraterrestrial origin. Extracts of CH chondrites were found to be particularly rich in amino acids (1316 parts per million, ppm) while CB chondrite extracts had much lower abundances (0.22 ppm). The amino acid distributions of the CH and CB chondrites were distinct from the distributions observed in type 2 and 3 CM and CR chondrites and contained elevated levels of beta-, gamma-, and delta-amino acids compared to the corresponding alpha-amino acids, providing evidence that multiple amino acid formation mechanisms were important in CH and CB chondrites.
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The extreme environments and their microbes as models for extraterrestrial life
Seckbach, J.; Oren, A.; Chela-Flores, J.
2008-09-01
Bacteria such as the aerobic Salinibacter ruber and the anaerobic members of the Halanaerobiales) use KCl to provide the necessary osmotic balance. Some of these extreme halophiles possess light-driven proton pumps (bacteriorhodopsin, xanthorhodopsin) and chloride pumps (halorhodopsin) that enable them to use photons to drive energetically expensive reactions (Oren, 2002; Oren, 2008). Extremophiles can serve as models for extraterrestrial microbes that may live in celestial bodies. The most promising among these to contain habitable areas are Mars (where the Phoenix Lander recently discovered water) and the Jovian satellite Europa; also Titan (the moon of Saturn) has some features that resemble those that may have existed on Earth during its earliest stages. From the characteristics of extremophilic microorganisms found on the present-day Earth, we can derive some insights on the question of habitability of other planets, and learn about possible bioindicators that may be suitable when searching for extraterrestrial life (Seckbach and Chela-Flores, 2007). Compounds such as methane on Mars or traces of sulfur on Jupiter's moon Europa may have been of biogenic origin and may possibly have been endogenic (Chela-Flores, 2006; Chela-Flores and Kumar, 2008). Biogeochemical tests have been proposed for missions that are in the planning stages, such as LAPLACE (Blanc et al., 2008), a mission to Europa and the Jupiter system by ESA's Cosmic Vision Programme. The finding of elemental sulfur on Europa may be of special interest. One possibility is that such traces of sulfur might have originated from the metabolism of extremophilic sulfurreducing microorganisms. Radiation may damage traces of biogenic sulfur deposited on the surface. The stopping depth for ionic radiation in the Jovian magnetosphere is expected not to exceed 1 cm (Greenberg, 2005; Dudeja et al., 2008). Thus, organic molecules would not be destroyed below such a thin layer. Based on to the preliminary results of the
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Peyre, Matthieu; Cartalat-Carel, Stéphanie; Meyronet, David; Ricard, Damien; Jouvet, Anne; Pallud, Johan; Mokhtari, Karima; Guyotat, Jacques; Jouanneau, Emmanuel; Sunyach, Marie-Pierre; Frappaz, Didier; Honnorat, Jérôme; Ducray, François
2010-01-01
Previous studies with temozolomide suggest that a prolonged duration of chemotherapy is important for treating low-grade gliomas (LGGs). PCV (procarbazine, CCNU, vincristine) chemotherapy has demonstrated efficacy in treating LGGs, but this therapy cannot be used for a prolonged period because of the cumulative toxicity. The aim of the present study was to evaluate the impact of first-line PCV chemotherapy on LGGs growth kinetics. The mean tumor diameter (MTD) of 21 LGGs was measured on serial magnetic resonance images before (n=13), during, and after PCV onset (n=21). During PCV treatment, a decrease in the MTD was observed in all patients. After PCV discontinuation, an ongoing decrease in MTD was observed in 20 of the 21 patients. Median duration of the MTD decrease was 3.4 years (range, 0.8–7.7) after PCV onset and 2.7 years (range, 0–7) after the end of PCV treatment with 60% of LGGs, demonstrating an ongoing and prolonged (>2 years) response despite chemotherapy no longer being administered. According to McDonald's criteria, the rates of partial and minor responses were 5% and 38% at the end of PCV but 38% and 42% at the time of maximal MTD decrease, which occurred after a median period of 3.4 years after PCV onset. These results challenge the idea that a prolonged duration of chemotherapy is necessary for treating LGGs and raise the issue of understanding the mechanisms involved in the persistent tumor volume decrease once chemotherapy is terminated. PMID:20488959
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Prenatal risk indicators of a prolonged pregnancy
DEFF Research Database (Denmark)
Olesen, Annette Wind; Westergaard, Jes Grabow; Olsen, Jørn
2006-01-01
BACKGROUND: Few prenatal risk factors of prolonged pregnancy, a pregnancy of 42 weeks or more, are known. The objective was to examine whether sociodemographic, reproductive, toxicologic, or medical health conditions were associated with the risk of prolonged pregnancy. METHODS: Data from...
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Does UTI cause prolonged jaundice in otherwise well infants?
Chowdhury, Tanzila; Kisat, Hamudi; Tullus, Kjell
2015-07-01
The symptoms of urinary tract infections in infants are very non-specific and have historically included prolonged hyperbilirubinaemia. We studied the results of routine urine samples in 319 infants with prolonged jaundice. Convincing findings of UTI was not found in any of these children even if one of them was treated with antibiotics after four consecutive urine cultures with different bacteria. A urine culture might thus not be an appropriate investigation in a child with prolonged jaundice without any other symptoms of UTI. • The symptoms of UTI in infancy are very non-specific. • Old studies suggest that prolonged hyperbilirubinaemia is one such symptom; more modern studies give more conflicting results. What is New: • Our study could not confirm that children with prolonged jaundice have an increased risk of UTI. • Routine urine testing is thus not needed in otherwise healthy infants with prolonged jaundice.
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Prolonged labour as indication for emergency caesarean section
DEFF Research Database (Denmark)
Maaløe, Nanna; Sorensen, B L; Onesmo, R
2012-01-01
To audit the quality of obstetric management preceding emergency caesarean sections for prolonged labour.......To audit the quality of obstetric management preceding emergency caesarean sections for prolonged labour....
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Prolonged Pregnancy: Methods, Causal Determinants and Outcome
DEFF Research Database (Denmark)
Olesen, Annette Wind
) to study the incidence of prolonged pregnancy as a function of methods for determining gestational age; 2) to determine the risk of obstetrical and fetal complications in prolonged pregnancy; 3) to validate the self-reported gestational age in the National Birth Cohort; 4) to determine whether...... an ultrasound scan in the first or second trimester, or menstrual history was best at predicting the day of delivery; 5) to study the risk of recurrence of prolonged pregnancy as a function of change in male partner, social status and municipality; and 6) to detect prenatal risk indicators of prolonged...... of perinatal and obstetrical complications was high in post-term delivery compared to term delivery (OR between 1.2 and 3.1). The risk of perinatal death (OR=1.36 (1.08-1.72)) was also higher in the post-term group (I). The self-reported gestational ages in the National Birth Cohort correlated well with data...
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Maaløe, N; Sorensen, B L; Onesmo, R; Secher, N J; Bygbjerg, I C
2012-04-01
To audit the quality of obstetric management preceding emergency caesarean sections for prolonged labour. A quality assurance analysis of a retrospective criterion-based audit supplemented by in-depth interviews with hospital staff. Two Tanzanian rural mission hospitals. Audit of 144 cases of women undergoing caesarean sections for prolonged labour; in addition, eight staff members were interviewed. Criteria of realistic best practice were established, and the case files were audited and compared with these. Hospital staff were interviewed about what they felt might be the causes for the audit findings. Prevalence of suboptimal management and themes emerging from an analysis of the transcripts. Suboptimal management was identified in most cases. Non-invasive interventions to potentially avoid operative delivery were inadequately used. When deciding on caesarean section, in 26% of the cases labour was not prolonged, and in 16% the membranes were still intact. Of the women with genuine prolonged labour, caesarean sections were performed with a fully dilated cervix in 36% of the cases. Vacuum extraction was not considered. Amongst the hospital staff interviewed, the awareness of evidence-based guidelines was poor. Word of mouth, personal experience, and fear, especially of HIV transmission, influenced management decisions. The lack of use and awareness of evidence-based guidelines led to misinterpretation of clinical signs, fear of simple interventions, and an excessive rate of emergency caesarean sections. © 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.
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Prolonged QRS Widening After Aripiprazole Overdose.
Mazer-Amirshahi, Maryann; Porter, Robert; Dewey, Kayla
2018-05-05
Aripiprazole is an atypical antipsychotic with a long half-life. Overdose can result in protracted somnolence and cardiac disturbances, particularly QT interval prolongation. This is a single case report of a 14-year-old boy who took an overdose of aripiprazole and developed QRS widening. A 14-year-old boy intentionally ingested 20 tablets of aripiprazole (5 mg). He was brought to the emergency department when his ingestion was discovered. The patient's vital signs were as follows: temperature, 37.7°C; heart rate, 108 beats/min; blood pressure, 138/98 mm Hg; and respirations, 16 breaths/min. Activated charcoal was administered within 90 minutes of ingestion. Initial electrocardiogram (EKG) showed sinus tachycardia, with a QRS of 138 ms and QT interval of 444 ms. QRS duration was 90 ms on an EKG performed 3 months earlier. A bolus of sodium bicarbonate was administered, and the patient was transferred to the pediatric intensive care unit. Repeat EKG demonstrated a QRS of 156 ms, and a sodium bicarbonate infusion was initiated. The patient continued to have QRS prolongation for the next 8 days, reaching a peak of 172 ms 3 days postingestion. Despite aggressive treatment with sodium bicarbonate, there was persistent QRS prolongation; however, the patient did not have any dysrhythmias and remained hemodynamically stable. The patient was discharged 9 days postingestion when the QRS duration normalized to 82 ms. Genetic testing revealed that the patient was a CYP2D6 poor metabolizer. This case suggests that aripiprazole toxicity may possibly be associated with QRS prolongation without associated dysrhythmias or cardiovascular compromise. In addition, toxicity may be prolonged in patients who are CYP2D6 poor metabolizers.
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Court, Richard W; Sims, Mark R; Cullen, David C; Sephton, Mark A
2014-09-01
Life-detection instruments on future Mars missions may use surfactant solutions to extract organic matter from samples of martian rocks. The thermal and radiation environments of space and Mars are capable of degrading these solutions, thereby reducing their ability to dissolve organic species. Successful extraction and detection of biosignatures on Mars requires an understanding of how degradation in extraterrestrial environments can affect surfactant performance. We exposed solutions of the surfactants polysorbate 80 (PS80), Zonyl FS-300, and poly[dimethylsiloxane-co-[3-(2-(2-hydroxyethoxy)ethoxy)propyl]methylsiloxane] (PDMSHEPMS) to elevated radiation and heat levels, combined with prolonged storage. Degradation was investigated by measuring changes in pH and electrical conductivity and by using the degraded solutions to extract a suite of organic compounds spiked onto grains of the martian soil simulant JSC Mars-1. Results indicate that the proton fluences expected during a mission to Mars do not cause significant degradation of surfactant compounds. Solutions of PS80 or PDMSHEPMS stored at -20 °C are able to extract the spiked standards with acceptable recovery efficiencies. Extraction efficiencies for spiked standards decrease progressively with increasing temperature, and prolonged storage at 60°C renders the surfactant solutions ineffective. Neither the presence of ascorbic acid nor the choice of solvent unequivocally alters the efficiency of extraction of the spiked standards. Since degradation of polysorbates has the potential to produce organic compounds that could be mistaken for indigenous martian organic matter, the polysiloxane PDMSHEPMS may be a superior choice of surfactant for the exploration of Mars.
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International Nuclear Information System (INIS)
Modica, Paola; De Marcellus, Pierre; D'Hendecourt, Louis Le Sergeant; Meinert, Cornelia; Meierhenrich, Uwe J.; Nahon, Laurent
2014-01-01
The discovery of meteoritic amino acids with enantiomeric excesses of the L-form (ee L ) has suggested that extraterrestrial organic materials may have contributed to prebiotic chemistry and directed the initial occurrence of the ee L that further led to homochirality of amino acids on Earth. A proposed mechanism for the origin of ee L in meteorites involves an asymmetric photochemistry of extraterrestrial ices by UV circularly polarized light (CPL). We have performed the asymmetric synthesis of amino acids on achiral extraterrestrial ice analogs by VUV CPL, investigating the chiral asymmetry transfer at two different evolutionary stages at which the analogs were irradiated (regular ices and/or organic residues) and at two different photon energies (6.6 and 10.2 eV). We identify 16 distinct amino acids and precisely measure the L-enantiomeric excesses using the enantioselective GC × GC-TOFMS technique in five of them: α-alanine, 2,3-diaminopropionic acid, 2-aminobutyric acid, valine, and norvaline, with values ranging from ee L = –0.20% ± 0.14% to ee L = –2.54% ± 0.28%. The sign of the induced ee L depends on the helicity and the energy of CPL, but not on the evolutionary stage of the samples, and is the same for all five considered amino acids. Our results support an astrophysical scenario in which the solar system was formed in a high-mass star-forming region where icy grains were irradiated during the protoplanetary phase by an external source of CPL of a given helicity and a dominant energy, inducing a stereo-specific photochemistry.
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Self-Healing Inflatable, Rigidizable Shelter for the Lunar Environment, Phase II
National Aeronautics and Space Administration — Any manned missions to extraterrestrial locations will require shelter structures for a variety of purposes ranging from habitat usage to biomass production. Such...
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Self-Healing Inflatable, Rigidizable Shelter for the Lunar Environment, Phase I
National Aeronautics and Space Administration — Any manned missions to extraterrestrial locations will require shelter structures for a variety of purposes ranging from habitat usage to biomass production. Such...
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International Nuclear Information System (INIS)
Wright, J. T.; Mullan, B.; Sigurdsson, S.; Povich, M. S.
2014-01-01
We motivate the Ĝ infrared search for extraterrestrial civilizations with large energy supplies. We discuss some philosophical difficulties of the search for extraterrestrial intelligence (SETI), and how communication SETI circumvents them. We review 'Dysonian SETI', the search for artifacts of alien civilizations, and find that it is highly complementary to traditional communication SETI; the two together might succeed where either one alone has not. We discuss the argument of Hart that spacefaring life in the Milky Way should be either galaxy-spanning or non-existent, and examine a portion of his argument that we call the 'monocultural fallacy'. We discuss some rebuttals to Hart that invoke sustainability and predict long Galaxy colonization timescales. We find that the maximum Galaxy colonization timescale is actually much shorter than previous work has found (<10 9 yr), and that many 'sustainability' counter-arguments to Hart's thesis suffer from the monocultural fallacy. We extend Hart's argument to alien energy supplies and argue that detectably large energy supplies can plausibly be expected to exist because life has the potential for exponential growth until checked by resources or other limitations, and intelligence implies the ability to overcome such limitations. As such, if Hart's thesis is correct, then searches for large alien civilizations in other galaxies may be fruitful; if it is incorrect, then searches for civilizations within the Milky Way are more likely to succeed than Hart argued. We review some past Dysonian SETI efforts and discuss the promise of new mid-infrared surveys, such as that of WISE.
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Long-life mission reliability for outer planet atmospheric entry probes
Mccall, M. T.; Rouch, L.; Maycock, J. N.
1976-01-01
The results of a literature analysis on the effects of prolonged exposure to deep space environment on the properties of outer planet atmospheric entry probe components are presented. Materials considered included elastomers and plastics, pyrotechnic devices, thermal control components, metal springs and electronic components. The rates of degradation of each component were determined and extrapolation techniques were used to predict the effects of exposure for up to eight years to deep space. Pyrotechnic devices were aged under accelerated conditions to an equivalent of eight years in space and functionally tested. Results of the literature analysis of the selected components and testing of the devices indicated that no severe degradation should be expected during an eight year space mission.
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Automation of Health Management, Troubleshooting and Recovery in Lunar Outpost, Phase I
National Aeronautics and Space Administration — NASA's Lunar and other future extraterrestrial outposts will be built for long duration missions that are likely to experience significant number of faults and...
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McCubbin, F. M.; Evans, C. A.; Fries, M. D.; Harrington, A. D.; Regberg, A. B.; Snead, C. J.; Zeigler, R. A.
2017-01-01
The Astromaterials Acquisition and Curation Office (henceforth referred to herein as NASA Curation Office) at NASA Johnson Space Center (JSC) is responsible for curating all of NASA's extraterrestrial samples. Under the governing document, NASA Policy Directive (NPD) 7100.10F JSC is charged with curation of all extraterrestrial material under NASA control, including future NASA missions. The Directive goes on to define Curation as including documentation, preservation, preparation, and distribution of samples for re-search, education, and public outreach. Here we briefly describe NASA's astromaterials collections and our ongoing efforts related to enhancing the utility of our current collections as well as our efforts to prepare for future sample return missions. We collectively refer to these efforts as advanced curation.
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Measurement of cosmogenic nuclides in extraterrestrial material
International Nuclear Information System (INIS)
Nishiizumi, K.; Arnold, J.R.
1981-01-01
Meteorites are rocks and pieces of iron-nickel alloy which fall to earth from time to time. They were formed about 4.6 billion years ago when our solar system was started. Thus it has been said that meteorites are the Rosetta stones of our solar system. We use the long-lived radioactive nuclides produced by cosmic ray bombardment, to study the history of the meteorites and also the history of the cosmic rays. When we have these historical facts in our hads, we hope we will be able to understand better how the solar system works, and how it got started. We can also learn more about the nature and origin of the cosmic rays. The accelerator mass spectrometry method helps not only reduce sample size, in most cases by two or three orders of magnitude, but opens another set of cosmogenic nuclides which have not been measured yet. Already 10 Be (t/sub 1/2 = 1.6 x 10 6 y), 36 Cl (3.0 x 10 5 y) and 129 I (1.6 x 10 7 y) in meteorites have been measured by accelerator mass spectrometry [3, 4, 7, 10]. Possible new candidates for measurement in extraterrestrial materials are 26 Al (7.2 x 10 5 y), 41 Ca (1.3 x 10 5 y), 60 Fe (approx. 10 5 y) and 59 Ni (7.6 x 10 4 y). We hope also to measure 146 Sm (1.0 x 10 8 y) and 92 Nb
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International law implications of the detection of extraterrestrial intelligent signals
Kopal, Vladimir
This paper first considers whether the present law of outer space, as it has been enshrined in five United Nations treaties and other legal documents concerning outer space, provides a satisfactory basis for SETI/CETI activities. In the author's opinion, these activities may serve "the common interest of all mankind in the progress of the exploration and use of outer space for peaceful purposes," as recognized in the 1967 Outer Space Treaty. The use of the radio frequency spectrum for SETI/CETI purposes should be in conformity with the legal principles governing this valuable natural resource, as expressed in the International Telecommunication Convention and related documents, and with allocations of the relevant segments of the spectrum by the competent bodies of the International Telecommunication Union. In the second part the author examines the impact that the detection of extraterrestrial intelligent signals may have on the present body of space law. A possible role for the United Nations in this respect is also explored and a timely interest of the world body in discussing questions relating to this subject is recommended. Consideration of these questions could become a tool helping to concentrate the attention of the world community on problems of common concern and thus to strengthen international cooperation. However, the author believes that a law-making process that would aim at elaborating a special regulation of activities in this field would be premature at this stage. It should be initiated only when the boundary between possibilities and realities is crossed. Finally, the paper outlines some likely transformation in our space law thinking that would be the consequence of the detection of extraterrestrial intelligent signals. Elaboration of the principles and norms to govern relations between the international community of our own planet and other intelligent communities in the universe would add a new dimension to the present body of outer space
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Artificial Gravity: Will it Preserve Bone Health on Long-Duration Missions?
Davis-Street, Janis; Paloski, William H.
2005-01-01
Prolonged microgravity exposure disrupts bone, muscle, and cardiovascular homeostasis, sensory-motor coordination, immune function, and behavioral performance. Bone loss, in particular, remains a serious impediment to the success of exploration-class missions by increasing the risks of bone fracture and renal stone formation for crew members. Current countermeasures, consisting primarily of resistive and aerobic exercise, have not yet proven fully successful for preventing bone loss during long-duration spaceflight. While other bone-specific countermeasures, such as pharmacological therapy and dietary modifications, are under consideration, countermeasure approaches that simultaneously address multiple physiologic systems may be more desirable for exploration-class missions, particularly if they can provide effective protection at reduced mission resource requirements (up-mass, power, crew time, etc). The most robust of the multi-system approaches under consideration, artificial gravity (AG), could prevent all of the microgravity-related physiological changes from occurring. The potential methods for realizing an artificial gravity countermeasure are reviewed, as well as selected animal and human studies evaluating the effects of artificial gravity on bone function. Future plans for the study of the multi-system effects of artificial gravity include a joint, cooperative international effort that will systematically seek an optimal prescription for intermittent AG to preserve bone, muscle, and cardiovascular function in human subjects deconditioned by 6 degree head-down-tilt-bed rest. It is concluded that AG has great promise as a multi-system countermeasure, but that further research is required to determine the appropriate parameters for implementation of such a countermeasure for exploration-class missions.
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New Fiber Reinforced Waterless Concrete for Extraterrestrial Structural Applications
Toutanji, H.; Tucker, D.; Ethridge, E.
2005-01-01
Commercial use of sulfur concrete on Earth is well established, particularly in corrosive, e.g., acid and salt, environments. Having found troilite (FeS) on the Moon raises the question of using extracted sulfur as a lunar construction mate: iii an attractive alternative to conventional concrete as it does not require water For the purpose of this paper it is assumed that lunar ore is mined, refined, and the raw sulfur processed with appropriate lunar regolith to form, for example, brick and beam elements. Glass fibers produced from regolith were used as a reinforcement to improve the mechanical properties of the sulfur concrete. Glass fibers and glass rebar were produced by melting the lunar regolith simulant. Lunar regolith stimulant was melted in a 25 cc Pt-Rh crucible in a Sybron Thermoline 46100 high temperature MoSi2 furnace at melting temperatures of 1450 to 1600G. The glass melt wets the ceramic rod and long continuous glass fibers were easily hand drawn. The glass fibers were immediately coated with a protective polymer to maintain the mechanical strength. The viability of sulfur concrete as a construction material for extraterrestrial application is presented. The mechanical properties of the glass fiber reinforced sulfur concrete were investigated.
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Pharmacometabolomic approach to predict QT prolongation in guinea pigs.
Directory of Open Access Journals (Sweden)
Jeonghyeon Park
Full Text Available Drug-induced torsades de pointes (TdP, a life-threatening arrhythmia associated with prolongation of the QT interval, has been a significant reason for withdrawal of several medicines from the market. Prolongation of the QT interval is considered as the best biomarker for predicting the torsadogenic risk of a new chemical entity. Because of the difficulty assessing the risk for TdP during drug development, we evaluated the metabolic phenotype for predicting QT prolongation induced by sparfloxacin, and elucidated the metabolic pathway related to the QT prolongation. We performed electrocardiography analysis and liquid chromatography-mass spectroscopy-based metabolic profiling of plasma samples obtained from 15 guinea pigs after administration of sparfloxacin at doses of 33.3, 100, and 300 mg/kg. Principal component analysis and partial least squares modelling were conducted to select the metabolites that substantially contributed to the prediction of QT prolongation. QTc increased significantly with increasing dose (r = 0.93. From the PLS analysis, the key metabolites that showed the highest variable importance in the projection values (>1.5 were selected, identified, and used to determine the metabolic network. In particular, cytidine-5'-diphosphate (CDP, deoxycorticosterone, L-aspartic acid and stearic acid were found to be final metabolomic phenotypes for the prediction of QT prolongation. Metabolomic phenotypes for predicting drug-induced QT prolongation of sparfloxacin were developed and can be applied to cardiac toxicity screening of other drugs. In addition, this integrative pharmacometabolomic approach would serve as a good tool for predicting pharmacodynamic or toxicological effects caused by changes in dose.
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Mission to Mars: Plans and concepts for the first manned landing
Oberg, J. E.
The manned exploration and settlement of Mars is discussed. The topics considered include: the rationale for a manned landing; spaceships and propulsion for getting to Mars; human factors such as psychological stress, the effects of prolonged weightlessness, and radiation dangers; the return from Mars; site selection and relevant criteria; scientific problems that can be studied by landing men on Mars. Also addressed are economic resources of air and water on Mars and their relevance for transportation and mission planning; the exploration and utilization of Phobos and Deimos; cost factors; the possibilities of the Russians' going to Mars; political and social issues; colonies on Mars; and manipulation of the Martian environment to make it more habitable.
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Astrobiology in culture: the search for extraterrestrial life as "science".
Billings, Linda
2012-10-01
This analysis examines the social construction of authority, credibility, and legitimacy for exobiology/astrobiology and, in comparison, the search for extraterrestrial intelligence (SETI), considering English-language conceptions of these endeavors in scientific culture and popular culture primarily in the United States. The questions that define astrobiology as a scientific endeavor are multidisciplinary in nature, and this endeavor is broadly appealing to public audiences as well as to the scientific community. Thus, it is useful to examine astrobiology in culture-in scientific culture, official culture, and popular culture. A researcher may explore science in culture, science as culture, by analyzing its rhetoric, the primary means that people use to construct their social realities-their cultural environment, as it were. This analysis follows this path, considering scientific and public interest in astrobiology and SETI and focusing on scientific and official constructions of the two endeavors. This analysis will also consider whether and how scientific and public conceptions of astrobiology and SETI, which are related but at the same time separate endeavors, converge or diverge and whether and how these convergences or divergences affect the scientific authority, credibility, and legitimacy of these endeavors.
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Detection of /sup 4/He in stratospheric particles gives evidence of extraterrestrial origin
Energy Technology Data Exchange (ETDEWEB)
Rajan, R S [Carnegie Institution of Washington, D.C. (USA). Dept. of Terrestrial Magnetism; Brownlee, D E; Tomandl, D; Hodge, P W; Farrar, H; Britten, R A
1977-05-12
The detection of large concentrations of /sup 4/He in some ..mu..m size stratospheric particles collected during the past 2 years is here reported. The final /sup 4/He concentrations ranged from 0.002 to 0.25 cc/gm. Such high concentrations confirm that the particles were extraterrestrial and that some of them were exposed to solar wind for at least 10 to 100 years; also, since solar wind ions are implanted only to depths of approximately 500 A, the measurements also indicate that the particles existed as small particles in space and were not produced in the atmosphere by fragmentation of larger meteoroids. The possibility that the observed He could have been the product of decaying U appears remote. Since micrometeorites probably have cometary origin, they are potentially a valuable source of primitive Solar System matter.
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Ruiz Moreno, J; Blanch Mon, A
2000-01-01
After having made a historical review of the concept of mission statement, of evaluating its importance (See Part I), of describing the bases to create a mission statement from a strategic perspective and of analyzing the advantages of this concept, probably more important as a business policy (See Parts I and II), the authors proceed to analyze the mission statement in health organizations. Due to the fact that a mission statement is lacking in the majority of health organizations, the strategy of health organizations are not exactly favored; as a consequence, neither are its competitive advantage nor the development of its essential competencies. After presenting a series of mission statements corresponding to Anglo-Saxon health organizations, the authors highlight two mission statements corresponding to our social context. The article finishes by suggesting an adequate sequence for developing a mission statement in those health organizations having a strategic sense.
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RD50 Prolongation Request 2018
Casse, Gianluigi
2018-01-01
With this document, we request the prolongation of the CERN RD50 research program for 5 years. A very brief historical review of the RD50 research program since the RD50 project approval by the Research Board in the year 2002 is presented and the biggest RD50 achievements are highlighted. The present composition of the collaboration, its organizational structure, and the research methodology are described. The role of RD50 in the present various upgrade and research programs of the LHC Experiments community is given and the overall work plan explained. Finally, a detailed 5-years work program with precise milestones and deliverables for the various research activities is presented. We conclude with our prolongation request towards the LHCC.
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Brucato, John Robert
2016-07-01
A mature European planetary exploration program and evolving sample return mission plans gathers the interest of a wider scientific community. The interest is generated from studying extraterrestrial samples in the laborato-ry providing new opportunities to address fundamental issues on the origin and evolution of the Solar System, on the primordial cosmochemistry, and on the nature of the building blocks of terrestrial planets and on the origin of life. Major space agencies are currently planning for missions that will collect samples from a variety of Solar Sys-tem environments, from primitive (carbonaceous) small bodies, from the Moon, Mars and its moons and, final-ly, from icy moons of the outer planets. A dedicated sample return curation facility is seen as an essential re-quirement for the receiving, assessment, characterization and secure preservation of the collected extraterrestrial samples and potentially their safe distribution to the scientific community. EURO-CARES is a European Commission study funded under the Horizon-2020 program. The strategic objec-tive of EURO-CARES is to create a roadmap for the implementation of a European Extraterrestrial Sample Cu-ration Facility. The facility has to provide safe storage and handling of extraterrestrial samples and has to enable the preliminary characterization in order to achieve the required effectiveness and collaborative outcomes for the whole international scientific community. For example, samples returned from Mars could pose a threat on the Earth's biosphere if any living extraterrestrial organism are present in the samples. Thus planetary protection is an essential aspect of all Mars sample return missions that will affect the retrival and transport from the point of return, sample handling, infrastructure methodology and management of a future curation facility. Analysis of the state of the art of Planetary Protection technology shows there are considerable possibilities to define and develop
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Fermionic covariant prolongation structure theory for supernonlinear evolution equation
International Nuclear Information System (INIS)
Cheng Jipeng; Wang Shikun; Wu Ke; Zhao Weizhong
2010-01-01
We investigate the superprincipal bundle and its associated superbundle. The super(nonlinear)connection on the superfiber bundle is constructed. Then by means of the connection theory, we establish the fermionic covariant prolongation structure theory of the supernonlinear evolution equation. In this geometry theory, the fermionic covariant fundamental equations determining the prolongation structure are presented. As an example, the supernonlinear Schroedinger equation is analyzed in the framework of this fermionic covariant prolongation structure theory. We obtain its Lax pairs and Baecklund transformation.
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EURO-CARES as Roadmap for a European Sample Curation Facility
Brucato, J. R.; Russell, S.; Smith, C.; Hutzler, A.; Meneghin, A.; Aléon, J.; Bennett, A.; Berthoud, L.; Bridges, J.; Debaille, V.; Ferrière, L.; Folco, L.; Foucher, F.; Franchi, I.; Gounelle, M.; Grady, M.; Leuko, S.; Longobardo, A.; Palomba, E.; Pottage, T.; Rettberg, P.; Vrublevskis, J.; Westall, F.; Zipfel, J.; Euro-Cares Team
2018-04-01
EURO-CARES is a three-year multinational project funded under the European Commission Horizon2020 research program to develop a roadmap for a European Extraterrestrial Sample Curation Facility for samples returned from solar system missions.
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Human Missions to Europa and Titan - Why Not?
Finarelli, Margaret G.
2004-04-01
This report describes a long-term development plan to enable human exploration of the outer solar system, with a focus on Europa and Titan. These are two of the most interesting moons of Jupiter and Saturn, respectively, because they are the places in the solar system with the greatest potential for harboring extraterrestrial life. Since human expeditions to these worlds are considered impossible with current capabilities, the proposal of a well-organized sequence of steps towards making this a reality was formulated. The proposed Development Plan, entitled Theseus, is the outcome of a recent multinational study by a group of students in the framework of the Master of Space Studies (MSS) 2004 course at the International Space University (ISU). The Theseus Program includes the necessary development strategies in key scientific and technological areas that are essential for identifying the requirements for the exploration of the outer planetary moons. Some of the topics that are analysed throughout the plan include: scientific observations at Europa and Titan, advanced propulsion and nuclear power systems, in-situ resource utilization, radiation mitigation techniques, closed life support systems, habitation for long-term spaceflight, and artificial gravity. In addition to the scientific and technological aspects of the Theseus Program, it was recognized that before any research and development work may begin, some level of program management must be established. Within this chapter, legal issues, national and international policy, motivation, organization and management, economic considerations, outreach, education, ethics, and social implications are all considered with respect to four possible future scenarios which enable human missions to the outer solar system. The final chapter of the report builds upon the foundations set by Theseus through a case study. This study illustrates how such accomplishments could influence a mission to Europa to search for evidence
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Human Missions to Europa and Titan - Why Not?
2004-01-01
This report describes a long-term development plan to enable human exploration of the outer solar system, with a focus on Europa and Titan. These are two of the most interesting moons of Jupiter and Saturn, respectively, because they are the places in the solar system with the greatest potential for harboring extraterrestrial life. Since human expeditions to these worlds are considered impossible with current capabilities, the proposal of a well-organized sequence of steps towards making this a reality was formulated. The proposed Development Plan, entitled Theseus, is the outcome of a recent multinational study by a group of students in the framework of the Master of Space Studies (MSS) 2004 course at the International Space University (ISU). The Theseus Program includes the necessary development strategies in key scientific and technological areas that are essential for identifying the requirements for the exploration of the outer planetary moons. Some of the topics that are analysed throughout the plan include: scientific observations at Europa and Titan, advanced propulsion and nuclear power systems, in-situ resource utilization, radiation mitigation techniques, closed life support systems, habitation for long-term spaceflight, and artificial gravity. In addition to the scientific and technological aspects of the Theseus Program, it was recognized that before any research and development work may begin, some level of program management must be established. Within this chapter, legal issues, national and international policy, motivation, organization and management, economic considerations, outreach, education, ethics, and social implications are all considered with respect to four possible future scenarios which enable human missions to the outer solar system. The final chapter of the report builds upon the foundations set by Theseus through a case study. This study illustrates how such accomplishments could influence a mission to Europa to search for evidence
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Management of prolonged pregnancy
International Nuclear Information System (INIS)
Iqbal, S.
2004-01-01
Objective: To compare two strategies for management of prolonged pregnancy (= or >294 days) i.e. induction (intervention) versus expectant management (non-intervention) and evaluate the associated feto-maternal risks. Subjects and Methods: One hundred cases of uncomplicated prolonged gestation were selected. The gestational age was confirmed by ultrasound in first trimester. One group (50 patients) was managed by intervention i.e. induction of labour (group A) and other group (50 patients) by non-intervention i.e. expectant management (group B). In group A intervention was done at 42 weeks. In expectant group, the methods of monitoring were fetal kick charting recorded daily by the patient, and ultrasound for amniotic fluid index. The biophysical profile score and NST (non stress test) were performed once a week till 42 weeks and then twice weekly. Results: The frequency of prolonged pregnancy was found to be 10.9%. There was no significant difference in the number of spontaneous vaginal deliveries between the two groups. The rate of LSCS (lower segment caesarean section) was higher in intervention group ( 30% versus 18% ). The neonatal depression at birth was more in group B ( 10% versus 4%) and at 5 minutes almost same between two groups (4% versus 2%). There were 11 cases of meconium aspiration syndrome, leading to one neonatal death. Among nine perinatal deaths two were neonatal deaths. Seven cases of intrauterine deaths in which antepartum deaths occurred because of non compliance of patients. No cause could be detected for the other three fetuses. Conclusion: There was increased LSCS rate in group A. However in expectant group B perinatal mortality was about twice more as compared to intervention group. Active early intervention at 42 weeks is warranted to reduce perinatal morbidity and mortality. (author)
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Rocco, David A.
1994-01-01
Redefining the approach and philosophy that operations management uses to define, develop, and implement space missions will be a central element in achieving high efficiency mission operations for the future. The goal of a cost effective space operations program cannot be realized if the attitudes and methodologies we currently employ to plan, develop, and manage space missions do not change. A management philosophy that is in synch with the environment in terms of budget, technology, and science objectives must be developed. Changing our basic perception of mission operations will require a shift in the way we view the mission. This requires a transition from current practices of viewing the mission as a unique end product, to a 'mission development concept' built on the visualization of the end-to-end mission. To achieve this change we must define realistic mission success criteria and develop pragmatic approaches to achieve our goals. Custom mission development for all but the largest and most unique programs is not practical in the current budget environment, and we simply do not have the resources to implement all of our planned science programs. We need to shift our management focus to allow us the opportunity make use of methodologies and approaches which are based on common building blocks that can be utilized in the space, ground, and mission unique segments of all missions.
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Vides, Christina; Macintosh, Bruce; Ruffio, Jean-Baptiste; Nielsen, Eric; Povich, Matthew Samuel
2018-01-01
Gemini Planet Imager (GPI) is a direct high contrast imaging instrument coupled to the Gemini South Telescope. Its purpose is to image extrasolar planets around young (~Intelligence), we modeled GPI’s capabilities to detect an extraterrestrial continuous wave (CW) laser broadcasted within the H-band have been modeled. By using sensitivity evaluated for actual GPI observations of young target stars, we produced models of the CW laser power as a function of distance from the star that could be detected if GPI were to observe nearby (~ 3-5 pc) planet-hosting G-type stars. We took a variety of transmitters into consideration in producing these modeled values. GPI is known to be sensitive to both pulsed and CW coherent electromagnetic radiation. The results were compared to similar studies and it was found that these values are competitive to other optical and infrared observations.
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Search for Signatures of Life in the Solar System
Race, M.; Schwehm, G.; Arnould, J.; Dawson, S.; Devore, E.; Evans, D.; Ferrazzani, M.; Shostak, S.
The search for evidence of extraterrestrial life is an important scientific theme that fascinates the public and encourages interest in space exploration, both within the solar system and beyond. The rapid pace of mass media communication allows the public to share mission results and new discoveries almost simultaneously with the scientific community. The public can read about proposed sample return missions to Mars, listen as scientists debate about in situ exploration of the oceans on Europa, learn about the growing number of extrasolar planets, or use their personal computers to participate in searches for extraterrestrial intelligence (SETI). As the science community continues its multi-pronged efforts to detect evidence of extraterrestrial life, it must be mindful of more than just science and technology. It is important to understand public perceptions, misperceptions, beliefs, concerns and potential complications associated with the search for life beyond our home planet. This panel is designed to provide brief overviews of some important non-scientific areas with the potential to impact future astrobiological exploration. The presentations will be followed by open discussion and audience participation. Invited panelists and their topical areas include: SCIENCE FICTION AND MISPERCEPTIONS: Seth Shostak, Dylan EvansBattling Pseudo-Science, Hollywood and Alien Abductions LEGAL ISSUES: Marcus FerrazzaniLooming Complications for Future Missions and Exploration RISK COMMUNICATION: Sandra DawsonEngaging the Public, Explaining the Risks, and Encouraging Long-Term Interestin Mission Science EDUCATION: Edna DeVoreUsing the Search for Life as a Motivating Theme in Teaching Basic Science andCritical Thinking. ETHICAL ISSUES AND CONCERNS: Jacques ArnouldWhat Will it Mean if We Find "ET"? PANEL MODERATORS: Margaret Race, Gerhard Schwehm
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SALIVARY ANTIMICROBIAL PROTEIN RESPONSE TO PROLONGED RUNNING
Directory of Open Access Journals (Sweden)
Suzanne Schneider
2013-01-01
Full Text Available Prolonged exercise may compromise immunity through a reduction of salivary antimicrobial proteins (AMPs. Salivary IgA (IgA has been extensively studied, but little is known about the effect of acute, prolonged exercise on AMPs including lysozyme (Lys and lactoferrin (Lac. Objective: To determine the effect of a 50-km trail race on salivary cortisol (Cort, IgA, Lys, and Lac. Methods: 14 subjects: (6 females, 8 males completed a 50km ultramarathon. Saliva was collected pre, immediately after (post and 1.5 hrs post race ( 1.5. Results: Lac concentration was higher at 1.5 hrs post race compared to post exercise (p0.05. IgA concentration, secretion rate, and IgA/Osm were lower 1.5 hrs post compared to pre race (p<0.05. Cort concentration was higher at post compared to 1.5 (p<0.05, but was unaltered from pre race levels. Subjects finished in 7.81 ± 1.2 hrs. Saliva flow rate did not differ between time points. Saliva Osm increased at post (p<0.05 compared to pre race. Conclusions: The intensity could have been too low to alter Lys and Lac secretion rates and thus, may not be as sensitive as IgA to changes in response to prolonged running. Results expand our understanding of the mucosal immune system and may have implications for predicting illness after prolonged running.
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Designing Mission Operations for the Gravity Recovery and Interior Laboratory Mission
Havens, Glen G.; Beerer, Joseph G.
2012-01-01
NASA's Gravity Recovery and Interior Laboratory (GRAIL) mission, to understand the internal structure and thermal evolution of the Moon, offered unique challenges to mission operations. From launch through end of mission, the twin GRAIL orbiters had to be operated in parallel. The journey to the Moon and into the low science orbit involved numerous maneuvers, planned on tight timelines, to ultimately place the orbiters into the required formation-flying configuration necessary. The baseline GRAIL mission is short, only 9 months in duration, but progressed quickly through seven very unique mission phases. Compressed into this short mission timeline, operations activities and maneuvers for both orbiters had to be planned and coordinated carefully. To prepare for these challenges, development of the GRAIL Mission Operations System began in 2008. Based on high heritage multi-mission operations developed by NASA's Jet Propulsion Laboratory and Lockheed Martin, the GRAIL mission operations system was adapted to meet the unique challenges posed by the GRAIL mission design. This paper describes GRAIL's system engineering development process for defining GRAIL's operations scenarios and generating requirements, tracing the evolution from operations concept through final design, implementation, and validation.
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Evolution of Orion Mission Design for Exploration Mission 1 and 2
Gutkowski, Jeffrey P.; Dawn, Timothy F.; Jedrey, Richard M.
2016-01-01
The evolving mission design and concepts of NASA’s next steps have shaped Orion into the spacecraft that it is today. Since the initial inception of Orion, through the Constellation Program, and now in the Exploration Mission frame-work with the Space Launch System (SLS), each mission design concept and pro-gram goal have left Orion with a set of capabilities that can be utilized in many different mission types. Exploration Missions 1 and 2 (EM-1 and EM-2) have now been at the forefront of the mission design focus for the last several years. During that time, different Design Reference Missions (DRMs) were built, analyzed, and modified to solve or mitigate enterprise level design trades to ensure a viable mission from launch to landing. The resulting DRMs for EM-1 and EM-2 were then expanded into multi-year trajectory scans to characterize vehicle performance as affected by variations in Earth-Moon geometry. This provides Orion’s subsystems with stressing reference trajectories to help design their system. Now that Orion has progressed through the Preliminary and Critical Design Reviews (PDR and CDR), there is a general shift in the focus of mission design from aiding the vehicle design to providing mission specific products needed for pre-flight and real time operations. Some of the mission specific products needed include, large quantities of nominal trajectories for multiple monthly launch periods and abort options at any point in the mission for each valid trajectory in the launch window.
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Computer graphics aid mission operations. [NASA missions
Jeletic, James F.
1990-01-01
The application of computer graphics techniques in NASA space missions is reviewed. Telemetric monitoring of the Space Shuttle and its components is discussed, noting the use of computer graphics for real-time visualization problems in the retrieval and repair of the Solar Maximum Mission. The use of the world map display for determining a spacecraft's location above the earth and the problem of verifying the relative position and orientation of spacecraft to celestial bodies are examined. The Flight Dynamics/STS Three-dimensional Monitoring System and the Trajectroy Computations and Orbital Products System world map display are described, emphasizing Space Shuttle applications. Also, consideration is given to the development of monitoring systems such as the Shuttle Payloads Mission Monitoring System and the Attitude Heads-Up Display and the use of the NASA-Goddard Two-dimensional Graphics Monitoring System during Shuttle missions and to support the Hubble Space Telescope.
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Stock, Eileen M; Zeber, John E; McNeal, Catherine J; Banchs, Javier E; Copeland, Laurel A
2018-04-01
In 2012, the Food and Drug Administration issued Drug Safety Communications on several drugs associated with QT prolongation and fatal ventricular arrhythmias. Among these was citalopram, a selective serotonin reuptake inhibitor (SSRI) approved for depression and commonly used for posttraumatic stress disorder (PTSD). Evaluation of the risk for QT prolongation among other psychotropic drugs for individuals with PTSD remains limited. Explore psychotropic drugs associated with QT prolongation among veterans with PTSD. Patients in the Veterans Health Administration in 2006-2009 with PTSD and QT prolongation (176 cases) were matched 1:4 on age, gender, visit date and setting, and physical comorbidity. Classification trees assessed QT prolongation risk among prescribed medications (n=880). Receipt of any drug with known risk of QT prolongation varied by group (23% QT cases vs 15% control, prisks included ziprasidone (3% vs 1%, p=0.02) and buspirone (6% vs 2%, p=0.01). Increased risk was not observed for the SSRIs, citalopram and fluoxetine. Classification trees found that sotalol and amitriptyline carried greater risk among cardiac patients and methadone, especially if prescribed with quetiapine, among noncardiac patients. Per adjusted survival model, patients with QT prolongation were at increased risk for death (hazard ratio=1.60; 95% CI=1.04-2.44). Decision models are particularly advantageous when exploring nonlinear relationships or nonadditive interactions. These findings may potentially affect clinical decision-making concerning treatment for PTSD. For patients at higher risk of QT prolongation, antidepressants other than amitriptyline should be considered. Medications for comorbid conditions should also be closely monitored for heightened QT prolongation risk.
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A new planetary mapping for future space missions
Karachevtseva, Irina; Kokhanov, Alexander; Rodionova, Janna; Zubarev, Anatoliy; Nadezhdina, Irina; Kreslavsky, Mikhail; Oberst, Jürgen
2015-04-01
The wide studies of Solar system, including different planetary bodies, were announced by new Russian space program. Their geodesy and cartography support provides by MIIGAiK Extraterrestrial Laboratory (http://mexlab.miigaik.ru/eng) in frames of the new project "Studies of Fundamental Geodetic Parameters and Topography of Planets and Satellites". The objects of study are satellites of the outer planets (satellites of Jupiter - Europa, Calisto and Ganymede; Saturnine satellite Enceladus), some planets (Mercury and Mars) and the satellites of the terrestrial planets - Phobos (Mars) and the Moon (Earth). The new research project, which started in 2014, will address the following important scientific and practical tasks: - Creating new three-dimensional geodetic control point networks of satellites of the outer planets using innovative photogrammetry techniques; - Determination of fundamental geodetic parameters and study size, shape, and spin parameters and to create the basic framework for research of their surfaces; - Studies of relief of planetary bodies and comparative analysis of general surface characteristics of the Moon, Mars, and Mercury, as well as studies of morphometric parameters of volcanic formations on the Moon and Mars; - Modeling of meteoritic bombardment of celestial bodies and the study of the dynamics of particle emissions caused by a meteorite impacts; - Development of geodatabase for studies of planetary bodies, including creation of object catalogues, (craters and volcanic forms, etc.), and thematic mapping using GIS technology. The significance of the project is defined both by necessity of obtaining fundamental characteristics of the Solar System bodies, and practical tasks in preparation for future Russian and international space missions to the Jupiter system (Laplace-P and JUICE), the Moon (Luna-Glob and Luna-Resource), Mars (Exo-Mars), Mercury (Bepi-Colombo), and possible mission to Phobos (project Boomerang). For cartographic support of
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The Significance of Prolonged and Saddleback Fever in Hospitalised Adult Dengue.
Directory of Open Access Journals (Sweden)
Deborah Hl Ng
Full Text Available Dengue fever is gaining importance in Singapore with an increase in the number of cases and mortality in recent years. Although prolonged and saddleback fever have been reported in dengue fever, there are no specific studies on their significance in dengue. This study aims to examine the prevalence of prolonged and saddleback fever in dengue as well as their associations with dengue severity. A total of 2843 polymerase-chain reaction (PCR confirmed dengue patients admitted to Tan Tock Seng Hospital from 2004 to 2008 were included in the study. Sixty-nine percent of them were male with a median age of 34 years. Prolonged fever (fever > 7 days duration was present in 572 (20.1% of patients. Dengue hemorrhagic fever (DHF, dengue shock syndrome (DSS and severe dengue (SD were significantly more likely to occur in patients with prolonged fever. Mucosal bleeding, anorexia, diarrhea, abdominal pain, nausea or vomiting, lethargy, rash, clinical fluid accumulation, hepatomegaly, nosocomial infection, leukopenia, higher neutrophil count, higher hematocrit, higher alanine transaminase (ALT and aspartate transaminase (AST, higher creatinine, lower protein and prolonged activated partial thromboplastin time (APTT were significantly associated with prolonged fever but not platelet count or prothrombin time (PT. Saddleback fever was present in 165 (5.8%. Although DHF and SD were more likely to occur in patients in those with saddleback fever, DSS was not. Compared with prolonged fever, saddleback fever did not show many significant associations except for diarrhea, abdominal pain, clinical fluid accumulation, hematocrit and platelet change, and lower systolic blood pressure. This study demonstrates that prolonged fever may be associated with various warning signs and more severe forms of dengue (SD, DSS, DHF, while saddleback fever showed associations with DHF and SD but not DSS. The presence of prolonged or saddleback fever in dengue patients should therefore
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Applying Biomimetic Algorithms for Extra-Terrestrial Habitat Generation
Birge, Brian
2012-01-01
The objective is to simulate and optimize distributed cooperation among a network of robots tasked with cooperative excavation on an extra-terrestrial surface. Additionally to examine the concept of directed Emergence among a group of limited artificially intelligent agents. Emergence is the concept of achieving complex results from very simple rules or interactions. For example, in a termite mound each individual termite does not carry a blueprint of how to make their home in a global sense, but their interactions based strictly on local desires create a complex superstructure. Leveraging this Emergence concept applied to a simulation of cooperative agents (robots) will allow an examination of the success of non-directed group strategy achieving specific results. Specifically the simulation will be a testbed to evaluate population based robotic exploration and cooperative strategies while leveraging the evolutionary teamwork approach in the face of uncertainty about the environment and partial loss of sensors. Checking against a cost function and 'social' constraints will optimize cooperation when excavating a simulated tunnel. Agents will act locally with non-local results. The rules by which the simulated robots interact will be optimized to the simplest possible for the desired result, leveraging Emergence. Sensor malfunction and line of sight issues will be incorporated into the simulation. This approach falls under Swarm Robotics, a subset of robot control concerned with finding ways to control large groups of robots. Swarm Robotics often contains biologically inspired approaches, research comes from social insect observation but also data from among groups of herding, schooling, and flocking animals. Biomimetic algorithms applied to manned space exploration is the method under consideration for further study.
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Prolonged social withdrawal disorder: a hikikomori case in Spain.
Ovejero, Santiago; Caro-Cañizares, Irene; de León-Martínez, Victoria; Baca-Garcia, Enrique
2014-09-01
The Japanese term hikikomori means literally 'to be confined'. Social withdrawal can be present in severe psychiatric disorders; however, in Japan, hikikomori is a defined nosologic entity. There have been only a few reported cases in occidental culture. We present a case report of a Spanish man with prolonged social withdrawal lasting for 4 years. This is a case of prolonged social withdrawal not bound to culture, as well as the second case of hikikomori reported in Spain. We propose prolonged social withdrawal disorder as a disorder not linked to culture, in contrast to hikikomori. Further documentation of this disorder is still needed to encompass all cases reported in Japan and around the world. © The Author(s) 2013.
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From Fossils to Astrobiology Records of Life on Earth and Search for Extraterrestrial Biosignatures
Seckbach, Joseph
2008-01-01
From Fossils to Astrobiology reviews developments in paleontology and geobiology that relate to the rapidly-developing field of Astrobiology, the study of life in the Universe. Many traditional areas of scientific study, including astronomy, chemistry and planetary science, contribute to Astrobiology, but the study of the record of life on planet Earth is critical in guiding investigations in the rest of the cosmos. In this varied book, expert scientists from 15 countries present peer-reviewed, stimulating reviews of paleontological and astrobiological studies. The overviews of established and emerging techniques for studying modern and ancient microorganisms on Earth and beyond, will be valuable guides to evaluating biosignatures which could be found in the extraterrestrial surface or subsurface within the Solar System and beyond. This volume also provides discussion on the controversial reports of "nanobacteria" in the Martian meteorite ALH84001. It is a unique volume among Astrobiology monographs in focusi...
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Zimmerman, G. A.; Gulkis, S.
1991-01-01
The sensitivity of a matched filter-detection system to a finite-duration continuous wave (CW) tone is compared with the sensitivities of a windowed discrete Fourier transform (DFT) system and an ideal bandpass filter-bank system. These comparisons are made in the context of the NASA Search for Extraterrestrial Intelligence (SETI) microwave observing project (MOP) sky survey. A review of the theory of polyphase-DFT filter banks and its relationship to the well-known windowed-DFT process is presented. The polyphase-DFT system approximates the ideal bandpass filter bank by using as few as eight filter taps per polyphase branch. An improvement in sensitivity of approx. 3 dB over a windowed-DFT system can be obtained by using the polyphase-DFT approach. Sidelobe rejection of the polyphase-DFT system is vastly superior to the windowed-DFT system, thereby improving its performance in the presence of radio frequency interference (RFI).
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Defining futile life-prolonging treatments through Neo-Socratic Dialogue.
Aizawa, Kuniko; Asai, Atsushi; Bito, Seiji
2013-12-09
In Japan, people are negative towards life-prolonging treatments. Laws that regulate withholding or discontinuing life-prolonging treatments and advance directives do not exist. Physicians, however, view discontinuing life-prolonging treatments negatively due to fears of police investigations. Although ministerial guidelines were announced regarding the decision process for end-of-life care in 2007, a consensus could not be reached on the definition of end-of-life and conditions for withholding treatment. We established a forum for extended discussions and consensus building on this topic. We used the Neo-Socratic Dialogue (NSD) method which promotes philosophical discussion based on a case-study to address a question and formulate a consensus and answer in a group. The question chosen for the dialogue was: "What is a life-prolonging treatment?" A series of dialogues took place over a period of one and a half days. It was carried out by three groups in 2010 and 2011. Seven participants with diverse backgrounds were recruited per group. We analyzed the content of the discussion. Based on three case studies concerning different opinions about treatment options for an older dementia patient, a patient demanding chemotherapy, and a severely ill neonate, conditions for futile life-prolonging treatment were elucidated through NSD. Such treatments are those carried out for the sole purpose of prolonging life and are detrimental to the patient, and should be decided based foremost on the patient's lack of desire for treatment, the consensus of those involved, and through social acceptance. These arguments are essentially consistent with ones on medical futility in the United States. By expressing the objective of healthcare and the requirement of social acceptance, participants were also able to elucidate issues related to the awareness of those involved and the medical environment. Compared to the end-of-life guidelines in Japan, the objective of treatment, its effects
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CIACCIO, EDWARD J.; BIVIANO, ANGELO B.; GAMBHIR, ALOK; EINSTEIN, ANDREW J.; GARAN, HASAN
2014-01-01
Background When atrial fibrillation (AF) is incessant, imaging during a prolonged ventricular RR interval may improve image quality. It was hypothesized that long RR intervals could be predicted from preceding RR values. Methods From the PhysioNet database, electrocardiogram RR intervals were obtained from 74 persistent AF patients. An RR interval lengthened by at least 250 ms beyond the immediately preceding RR interval (termed T0 and T1, respectively) was considered prolonged. A two-parameter scatterplot was used to predict the occurrence of a prolonged interval T0. The scatterplot parameters were: (1) RR variability (RRv) estimated as the average second derivative from 10 previous pairs of RR differences, T13–T2, and (2) Tm–T1, the difference between Tm, the mean from T13 to T2, and T1. For each patient, scatterplots were constructed using preliminary data from the first hour. The ranges of parameters 1 and 2 were adjusted to maximize the proportion of prolonged RR intervals within range. These constraints were used for prediction of prolonged RR in test data collected during the second hour. Results The mean prolonged event was 1.0 seconds in duration. Actual prolonged events were identified with a mean positive predictive value (PPV) of 80% in the test set. PPV was >80% in 36 of 74 patients. An average of 10.8 prolonged RR intervals per 60 minutes was correctly identified. Conclusions A method was developed to predict prolonged RR intervals using two parameters and prior statistical sampling for each patient. This or similar methodology may help improve cardiac imaging in many longstanding persistent AF patients. PMID:23998759
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Women's experiences of becoming a mother after prolonged labour.
Nystedt, Astrid; Högberg, Ulf; Lundman, Berit
2008-08-01
This paper is a report of a study to explore women's experiences of becoming a mother after prolonged labour. The negativity associated with a complicated labour such as prolonged labour can lead to a struggle to become a healthy mother and could restrict the process of becoming a mother. Interviews were conducted in 2004 with 10 mothers who had been through a prolonged labour with assisted vaginal or caesarean delivery 1-3 months previously. Thematic content analysis was used. Three themes were formulated, describing women's experiences as fumbling in the dark, struggling for motherhood and achieving confidence in being a mother. The difficulties and suffering involved in becoming a mother after a prolonged labour were interpreted to be like 'fumbling in the dark'. Women experienced bodily fatigue, accompanied by feelings of illness and detachment from the child. Having the child when in this condition entailed a struggle to become a mother. In spite of these experiences and the desire to achieve confidence in being a mother, the reassurance of these women regarding their capacity for motherhood was crucial: it was central to their happiness as mothers, encouraged interaction and relationship with the child, and contributed to their adaptation to motherhood. Women experiencing prolonged labour may be comparable with the experience of and recovery from illness, which could contribute to difficulties transitioning to motherhood and limit a woman's ability to be emotionally available for the child.
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Prolonged unexplained fatigue in paediatrics
Bakker, R.J.
2010-01-01
Prolonged Unexplained Fatigue in Paediatrics. Fatigue, as the result of mental or physical exertion, will disappear after rest, drinks and food. Fatigue as a symptom of illness will recover with the recovering of the illness. But when fatigue is ongoing for a long time, and not the result of
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Contour Crafting Simulation Plan for Lunar Settlement Infrastructure Build-Up
Khoshnevis, B.; Carlson, A.; Leach N.; Thangavelu, M.
2016-01-01
Economically viable and reliable building systems and tool sets are being sought, examined and tested for extraterrestrial infrastructure buildup. This project focused on a unique architecture weaving the robotic building construction technology with designs for assisting rapid buildup of initial operational capability Lunar and Martian bases. The project aimed to study new methodologies to construct certain crucial infrastructure elements in order to evaluate the merits, limitations and feasibility of adapting and using such technologies for extraterrestrial application. Current extraterrestrial settlement buildup philosophy holds that in order to minimize the materials needed to be flown in, at great transportation costs, strategies that maximize the use of locally available resources must be adopted. Tools and equipment flown as cargo from Earth are proposed to build required infrastructure to support future missions and settlements on the Moon and Mars.
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Alfandari, B; Persichetti, P; Pelissier, P; Martin, D; Baudet, J
2004-06-01
The authors report the accomplishment of humanitarian missions in plastic surgery performed by a small team in town practice in Yangon, about their 3 years experience in Myanmar with 300 consultations and 120 surgery cases. They underline the interest of this type of mission and provide us their reflexion about team training, the type of relation with the country where the mission is conducted and the type of right team.
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Does a 'tight' hamstring predict low back pain reporting during prolonged standing?
Raftry, Sean M; Marshall, Paul W M
2012-06-01
The purpose of this study was to investigate the relationship between hamstring passive stiffness and extensibility in asymptomatic individuals with the reporting of low back pain during 2-h prolonged standing. Twenty healthy participants with no history of low back pain (mean±SD, age 22.6±2.7 years, height 1.74±0.09 m, weight 76.2±14.8 kg). Low back pain (VAS score; mm) was continuously monitored during 2-h prolonged standing. Hamstring extensibility, passive stiffness, and stretch tolerance were measured before and after prolonged standing using an instrumented straight leg raise (iSLR). Ten participants reported a clinically relevant increase (Δ VAS>10mm) in low back pain during prolonged standing. Hamstring extensiblity (leg°(max)), passive stiffness (Nm.°(-1)), and stretch tolerance (VAS; mm) were no different between pain developers and non-pain developers. No changes in hamstring measures were observed following 2-h prolonged standing. No relationship was observed in this study between measures of hamstring extensibility and the reporting of low back pain during prolonged standing. There is no evidence to recommend hamstring extensibility interventions (i.e. passive stretching) as a means of reducing pain reporting in occupations requiring prolonged standing. Copyright © 2012 Elsevier Ltd. All rights reserved.
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Invited Review Article: Advanced light microscopy for biological space research
De Vos, W.H.; Beghuin, D.; Schwarz, C.J.; Jones, D.B.; van Loon, J.J.W.A.; Bereiter-Hahn, J.; Stelzer, E.H.K.
2014-01-01
As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as
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Invited review article: advanced light microscopy for biological space research
De Vos, W.H.; Beghuin, D.; Schwarz, C.J.; Jones, D.B.; van Loon, J.J.W.A.; Bereiter-Hahn, J.; Stelzer, E.H.K.
2014-01-01
As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as
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Business analysis: The commercial mission of the International Asteroid Mission
The mission of the International Asteroid Mission (IAM) is providing asteroidal resources to support activities in space. The short term goal is to initiate IAM by mining a near-Earth, hydrous carbonaceous chondrite asteroid to service the nearer-term market of providing cryogenic rocket fuel in low lunar orbit (LLO). The IAM will develop and contract for the building of the transportation vehicles and equipment necessary for this undertaking. The long-term goal is to expand operations by exploiting asteroids in other manners, as these options become commercially viable. The primary business issues are what revenue can be generated from the baseline mission, how much will the mission cost, and how funding for this mission can be raised. These issues are addressed.
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Hyland, R. E.; Wohl, M. L.; Thompson, R. L.; Finnegan, P. M.
1972-01-01
The results are reported of a preliminary feasibility screening study for providing long-term solutions to the problems of handling and managing radioactive wastes by extraterrestrial transportation of the wastes. Matrix materials and containers are discussed along with payloads, costs, and destinations for candidate space vehicles. The conclusions reached are: (1) Matrix material such as spray melt can be used without exceeding temperature limits of the matrix. (2) The cost in mills per kw hr electric, of space disposal of fission products is 4, 5, and 28 mills per kw hr for earth escape, solar orbit, and solar escape, respectively. (3) A major factor effecting cost is the earth storage time. Based on a normal operating condition design for solar escape, a storage time of more than sixty years is required to make the space disposal charge less than 10% of the bus-bar electric cost. (4) Based on a 10 year earth storage without further processing, the number of shuttle launches required would exceed one per day.
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A mission to Mercury and a mission to the moons of Mars
1993-07-01
Two Advanced Design Projects were completed this academic year at Penn State - a mission to the planet Mercury and a mission to the moons of Mars (Phobos and Deimos). At the beginning of the fall semester the students were organized into six groups and given their choice of missions. Once a mission was chosen, the students developed conceptual designs. These designs were then evaluated at the end of the fall semester and combined into two separate mission scenarios. To facilitate the work required for each mission, the class was reorganized in the spring semester by combining groups to form two mission teams. An integration team consisting of two members from each group was formed for each mission team so that communication and exchange of information would be easier among the groups. The types of projects designed by the students evolved from numerous discussions with Penn State faculty and mission planners at the Lewis Research Center Advanced Projects Office. Robotic planetary missions throughout the solar system can be considered valuable precursors to human visits and test beds for innovative technology. For example, by studying the composition of the Martian moons, scientists may be able to determine if their resources may be used or synthesized for consumption during a first human visit.
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If technological intelligent extraterrestrials exist, what biological traits are de rigueur
Taylor, E. R.
2018-05-01
If extraterrestrials exist in the depths of cosmic space, and are capable of interstellar communications, even space flight, there is no requirement that they be humanoid in form. However, certain humanoid capabilities would be advantageous for tool fashioning and critical to operating space craft as well as functioning under the disparate extreme conditions under which they may be forced to operate. They would have to be "gas breathing". The reasonable assumption that life based upon the same elements as Earth life requiring water stems from the unique properties of water that no other similar low molecular weight nonmetal hydride offers. Only water offers the diversity of chemical properties and reactivity, including the existence of the three common physical states within a limited temperature range of service to life, avoiding the issues presented by any alternatives. They must, like us, possess a large, abstract-thinking brain, and probably possess at least all the fundamental senses that humankind possess. They would also be carbon-based life, using oxygen as the electron sink of their biochemistry for the reasons considered. They most likely are homeothermic as us, though they may not necessarily be mammalian as we are. Their biochemistry could differ some from ours, perhaps presenting contact hazards for both species as discussed.
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International Nuclear Information System (INIS)
Jain, P.C.
1984-01-01
The monthly average daily values of the extraterrestrial irradiation on a horizontal surface (H 0 ) and the maximum possible sunshine duration are two important parameters that are frequently needed in various solar energy applications. These are generally calculated by scientists each time they are needed and by using the approximate short-cut methods. Computations for these values have been made once and for all for latitude values of 60 deg. N to 60 deg. S at intervals of 1 deg. and are presented in a convenient tabular form. Values of the maximum possible sunshine duration as recorded on a Campbell Stoke's sunshine recorder are also computed and presented. These tables should avoid the need for repetition and approximate calculations and serve as a useful ready reference for solar energy scientists and engineers. (author)
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Traphagan, John
2015-01-01
The search for extraterrestrial intelligence (SETI) represents one of the most significant crossroads at which the assumptions and methods of scientific inquiry come into direct contact with—and in many cases conflict with—those of religion. Indeed, at the core of SETI is the same question that motivates many interested in religion: What is the place of humanity in the universe? Both scientists involved with SETI (and in other areas) and those interested in and dedicated to some religious traditions are engaged in contemplating these types of questions, even if their respective approaches and answers differ significantly. This book explores this intersection with a focus on three core points: 1) the relationship between science and religion as it is expressed within the framework of SETI research, 2) the underlying assumptions, many of which are tacitly based upon cultural values common in American society, that have shaped the ways in which SETI researchers have conceptualized the nature of their endeavo...
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International Nuclear Information System (INIS)
Jain, P.C.
1985-12-01
The monthly average daily values of the extraterrestrial irradiation on a horizontal plane and the maximum possible sunshine duration are two important parameters that are frequently needed in various solar energy applications. These are generally calculated by solar scientists and engineers each time they are needed and often by using the approximate short-cut methods. Using the accurate analytical expressions developed by Spencer for the declination and the eccentricity correction factor, computations for these parameters have been made for all the latitude values from 90 deg. N to 90 deg. S at intervals of 1 deg. and are presented in a convenient tabular form. Monthly average daily values of the maximum possible sunshine duration as recorded on a Campbell Stoke's sunshine recorder are also computed and presented. These tables would avoid the need for repetitive and approximate calculations and serve as a useful ready reference for providing accurate values to the solar energy scientists and engineers
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2014-01-01
Background Prolonged labour very often causes suffering from difficulties that may have lifelong implications. This study aimed to explore the prevalence and treatment of prolonged labour and to compare birth outcome and women’s experiences of prolonged and normal labour. Method Women with spontaneous onset of labour, living in a Swedish county, were recruited two months after birth, to a cross-sectional study. Women (n = 829) completed a questionnaire that investigated socio-demographic and obstetric background, birth outcome and women’s feelings and experiences of birth. The prevalence of prolonged labour, as defined by a documented ICD-code and inspection of partogram was calculated. Four groups were identified; women with prolonged labour as identified by documented ICD-codes or by partogram inspection but no ICD-code; women with normal labour augmented with oxytocin or not. Results Every fifth woman experienced a prolonged labour. The prevalence with the documented ICD-code was (13%) and without ICD-code but positive partogram was (8%). Seven percent of women with prolonged labour were not treated with oxytocin. Approximately one in three women (28%) received oxytocin augmentation despite having no evidence of prolonged labour. The length of labour differed between the four groups of women, from 7 to 23 hours. Women with a prolonged labour had a negative birth experience more often (13%) than did women who had a normal labour (3%) (P women with prolonged labour were emergency Caesarean section (OR 9.0, 95% CI 1.2-3.0) and to strongly agree with the following statement ‘My birth experience made me decide not to have any more children’ (OR 41.3, 95% CI 4.9-349.6). The factors that contributed most strongly to a negative birth experience in women with normal labour were less agreement with the statement ‘It was exiting to give birth’ (OR 0.13, 95% CI 0.34-0.5). Conclusions There is need for increased clinical skill in identification and classification
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Bomber Deterrence Missions: Criteria To Evaluate Mission Effectiveness
2016-02-16
international security, the practice of general deterrence usually occurs when nations feel insecure , suspicious or even hostility towards them but...both a deterrence and assurance mission even though it was not planned or advertised as such. Since the intent of this mission was partly perceived
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Prolonged fasting activates Nrf2 in post-weaned elephant seals.
Vázquez-Medina, José Pablo; Soñanez-Organis, José G; Rodriguez, Ruben; Viscarra, Jose A; Nishiyama, Akira; Crocker, Daniel E; Ortiz, Rudy M
2013-08-01
Elephant seals naturally experience prolonged periods of absolute food and water deprivation (fasting). In humans, rats and mice, prolonged food deprivation activates the renin-angiotensin system (RAS) and increases oxidative damage. In elephant seals, prolonged fasting activates RAS without increasing oxidative damage likely due to an increase in antioxidant defenses. The mechanism leading to the upregulation of antioxidant defenses during prolonged fasting remains elusive. Therefore, we investigated whether prolonged fasting activates the redox-sensitive transcription factor Nrf2, which controls the expression of antioxidant genes, and if such activation is potentially mediated by systemic increases in RAS. Blood and skeletal muscle samples were collected from seals fasting for 1, 3, 5 and 7 weeks. Nrf2 activity and nuclear content increased by 76% and 167% at week 7. Plasma angiotensin II (Ang II) and transforming growth factor β (TGF-β) were 5000% and 250% higher at week 7 than at week 1. Phosphorylation of Smad2, an effector of Ang II and TGF signaling, increased by 120% at week 7 and by 84% in response to intravenously infused Ang II. NADPH oxidase 4 (Nox4) mRNA expression, which is controlled by smad proteins, increased 430% at week 7, while Nox4 protein expression, which can activate Nrf2, was 170% higher at week 7 than at week 1. These results demonstrate that prolonged fasting activates Nrf2 in elephant seals and that RAS stimulation can potentially result in increased Nox4 through Smad phosphorylation. The results also suggest that Nox4 is essential to sustain the hormetic adaptive response to oxidative stress in fasting seals.
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AORN Ergonomic Tool 4: Solutions for Prolonged Standing in Perioperative Settings.
Hughes, Nancy L; Nelson, Audrey; Matz, Mary W; Lloyd, John
2011-06-01
Prolonged standing during surgical procedures poses a high risk of causing musculoskeletal disorders, including back, leg, and foot pain, which can be chronic or acute in nature. Ergonomic Tool 4: Solutions for Prolonged Standing in Perioperative Settings provides recommendations for relieving the strain of prolonged standing, including the use of antifatigue mats, supportive footwear, and sit/stand stools, that are based on well-accepted ergonomic safety concepts, current research, and access to new and emerging technology. Published by Elsevier Inc.
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Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia
Directory of Open Access Journals (Sweden)
Christina Bognet
2011-12-01
Full Text Available Currently available local anesthetics have analgesic durations in humans generally less than 12 hours. Prolonged-duration local anesthetics will be useful for postoperative analgesia. Previous studies showed that in rats, combinations of tetrodotoxin (TTX with bupivacaine had supra-additive effects on sciatic block durations. In those studies, epinephrine combined with TTX prolonged blocks more than 10-fold, while reducing systemic toxicity. TTX, formulated as Tectin, is in phase III clinical trials as an injectable systemic analgesic for chronic cancer pain. Here, we examine dose-duration relationships and sciatic nerve histology following local nerve blocks with combinations of Tectin with bupivacaine 0.25% (2.5 mg/mL solutions, with or without epinephrine 5 µg/mL (1:200,000 in rats. Percutaneous sciatic blockade was performed in Sprague-Dawley rats, and intensity and duration of sensory blockade was tested blindly with different Tectin-bupivacaine-epinephrine combinations. Between-group comparisons were analyzed using ANOVA and post-hoc Sidak tests. Nerves were examined blindly for signs of injury. Blocks containing bupivacaine 0.25% with Tectin 10 µM and epinephrine 5 µg/mL were prolonged by roughly 3-fold compared to blocks with bupivacaine 0.25% plain (P < 0.001 or bupivacaine 0.25% with epinephrine 5 µg/mL (P < 0.001. Nerve histology was benign for all groups. Combinations of Tectin in bupivacaine 0.25% with epinephrine 5 µg/mL appear promising for prolonged duration of local anesthesia.
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MRI findings of prolonged post-traumatic sternal pain
International Nuclear Information System (INIS)
Grosse, Alexandra; Grosse, Claudia; Anderson, Suzanne; Steinbach, Lynne
2007-01-01
The objective of this study was to characterize the different causes of prolonged sternal pain following thoracic trauma with involvement of the sternum and to define criteria for sternal nonunion diagnosis using MRI. Five patients with abnormalities of the sternum were evaluated for prolonged sternal pain following thoracic trauma using MRI. MR images were evaluated by two radiologists in consensus. The patients were selected from the radiology database, which included 8 patients with post-traumatic prolonged sternal pain. Two patients (n = 2) revealed a sternal nonunion after sternal fracture. One patient had a sternal fracture with delayed union and minor displacement of the sternal halves. Abnormal signal intensity alterations adjacent to and within the manubrio-sternal joint were evident in 2 patients and considered due to trauma-related changes in the manubrio-sternal joint. The 3 patients who were not included in the study had no abnormalities of the sternum: 1 of them proved to have a well-healed sternal fracture and nonunion of a rib fracture, 1 had subtle Tietze's syndrome, and 1 patient revealed no pathological findings on imaging. Various factors may be responsible for prolonged sternal pain following thoracic trauma, and these can be viewed with MRI. In cases of sternal nonunion there was common fluid-like signal in the fracture interspace between the bony edges, and the bone marrow adjacent to the nonunion showed altered signal intensity. MRI identified sternal nonunion and other trauma-related abnormalities of the sternum following chest trauma. (orig.)
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The Impact of Mission Duration on a Mars Orbital Mission
Arney, Dale; Earle, Kevin; Cirillo, Bill; Jones, Christopher; Klovstad, Jordan; Grande, Melanie; Stromgren, Chel
2017-01-01
Performance alone is insufficient to assess the total impact of changing mission parameters on a space mission concept, architecture, or campaign; the benefit, cost, and risk must also be understood. This paper examines the impact to benefit, cost, and risk of changing the total mission duration of a human Mars orbital mission. The changes in the sizing of the crew habitat, including consumables and spares, was assessed as a function of duration, including trades of different life support strategies; this was used to assess the impact on transportation system requirements. The impact to benefit is minimal, while the impact on cost is dominated by the increases in transportation costs to achieve shorter total durations. The risk is expected to be reduced by decreasing total mission duration; however, large uncertainty exists around the magnitude of that reduction.
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Logistics Needs for Potential Deep Space Mission Scenarios Post Asteroid Crewed Mission
Lopez, Pedro, Jr.
2015-01-01
A deep-space mission has been proposed to identify and redirect an asteroid to a distant retrograde orbit around the moon, and explore it by sending a crew using the Space Launch System and the Orion spacecraft. The Asteroid Redirect Crewed Mission (ARCM), which represents the third segment of the Asteroid Redirect Mission (ARM), could be performed on EM-3 or EM-4 depending on asteroid return date. Recent NASA studies have raised questions on how we could progress from current Human Space Flight (HSF) efforts to longer term human exploration of Mars. This paper will describe the benefits of execution of the ARM as the initial stepping stone towards Mars exploration, and how the capabilities required to send humans to Mars could be built upon those developed for the asteroid mission. A series of potential interim missions aimed at developing such capabilities will be described, and the feasibility of such mission manifest will be discussed. Options for the asteroid crewed mission will also be addressed, including crew size and mission duration.
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Homes for extraterrestrial life: extrasolar planets.
Latham, D W
2001-12-01
Astronomers are now discovering giant planets orbiting other stars like the sun by the dozens. But none of these appears to be a small rocky planet like the earth, and thus these planets are unlikely to be capable of supporting life as we know it. The recent discovery of a system of three planets is especially significant because it supports the speculation that planetary systems, as opposed to single orbiting planets, may be common. Our ability to detect extrasolar planets will continue to improve, and space missions now in development should be able to detect earth-like planets.
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Physiology Of Prolonged Bed Rest
Greenleaf, John E.
1991-01-01
Report describes physiological effects of prolonged bed rest. Rest for periods of 24 hours or longer deconditions body to some extent; healing proceeds simultaneously with deconditioning. Report provides details on shifts in fluid electrolytes and loss of lean body mass, which comprises everything in body besides fat - that is, water, muscle, and bone. Based on published research.
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Murrell, M. T.; Davis, P. A., Jr.; Nishiizumi, K.; Millard, H. T., Jr.
1980-01-01
From 411 kg of Pacific clay, 22 mg of stony spherules and 50 mg of iron spherules larger than 150 microns were concentrated. The extraterrestrial origin of these particles was evaluated with the aid of optical and electron microscopy and atomic absorption elemental analysis. An expression for the integral number of stony particles from this sediment in the mass range 20-300 micrograms was derived. The world-wide influx rate of stony particles in the mass range which survive atmospheric heating and ocean sediment storage is calculated to be 90 tons/yr. The relative contributions of ablation debris vs fused interplanetary dust to the influx of stony spherules is discussed, but no conclusions could be made.
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Cardiovascular drugs inducing QT prolongation: facts and evidence.
Taira, Carlos A; Opezzo, Javier A W; Mayer, Marcos A; Höcht, Christian
2010-01-01
Acquired QT syndrome is mainly caused by the administration of drugs that prolong ventricular repolarization. On the other hand, the risk of drug-induced torsades de pointes is increased by numerous predisposing factors, such as genetic predisposition, female sex, hypokalemia and cardiac dysfunction. This adverse reaction is induced by different chemical compounds used for the treatment of a variety of pathologies, including arrhythmias. As it is known, antiarrhythmic agents and other cardiovascular drugs can prolong the QT interval, causing this adverse reaction. Of the 20 most commonly reported drugs, 10 were cardiovascular agents and these appeared in 348 of the reports (46%). Class Ia antiarrhythmic agents have frequently been linked to inducing arrhythmia, including torsades de pointes. Sotalol and amiodarone, class III antiarrhythmics, are known to prolong the QT interval by blocking I(Kr). Due to the severity of events caused by the therapeutic use of these drugs, in this work of revision the cardiovascular drugs that present this property and the factors and evidence will be mentioned.
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Zubrin, Robert
1994-07-01
This paper examines the possibility of detecting extraterrestrial civilizations by means of searching for the spectral signature of their interstellar transportation systems. The advantage of such an approach is that the characteristic power levels associated with interstellar transportation systems are many orders of magnitude greater than those required for communication, and so the signal strength may be much greater. Furthermore, unlike communication which is governed by a fairly arbitrary selection of technology and mutually agreed upon conventions, interstellar transportation systems are governed much more stringently by the laws of physics. For purposes of the present analysis we consider 4 methods of interstellar propulsion, the principles of which are fairly well understood. These are anti-matter rockets, fusion rockets, fission rockets, all of which can be used to either accelerate or decelerate a spacecraft, and magnetic sails, which can be used to decelerate a spacecraft by creating drag against the interstellar medium. The types of radiation emitted by each of these propulsion systems is described, and the signal strength for starships of a characteristic mass of 1 million tonnes traveling at speeds and acceleration levels characteristic of the various propulsion systems is estimated. It is shown that for the power level of ships considered, the high energy gamma radiation emitted by the anti-matter, fusion and fission propulsion systems would be undetectable at interstellar distances. Better opportunities for detection would be the bremsstrahlung radiation from the plasma confinement systems of fusion devices, which might be detectable at distances of about 1 light year, and visible light emitted from the radiators of anti-matter driven photon rocket, which might be detectable by the Hubble Space Telescope at a distance of several hundred light years provided the rocket nozzle is oriented towards the Earth. The most detectable form of starship
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MRI findings of prolonged post-traumatic sternal pain
Energy Technology Data Exchange (ETDEWEB)
Grosse, Alexandra; Grosse, Claudia; Anderson, Suzanne [University Hospital of Berne, Department of Diagnostic, Pediatric and Interventional Radiology, Berne (Switzerland); Steinbach, Lynne [University of California San Francisco, Department of Radiology, San Francisco, CA (United States)
2007-05-15
The objective of this study was to characterize the different causes of prolonged sternal pain following thoracic trauma with involvement of the sternum and to define criteria for sternal nonunion diagnosis using MRI. Five patients with abnormalities of the sternum were evaluated for prolonged sternal pain following thoracic trauma using MRI. MR images were evaluated by two radiologists in consensus. The patients were selected from the radiology database, which included 8 patients with post-traumatic prolonged sternal pain. Two patients (n = 2) revealed a sternal nonunion after sternal fracture. One patient had a sternal fracture with delayed union and minor displacement of the sternal halves. Abnormal signal intensity alterations adjacent to and within the manubrio-sternal joint were evident in 2 patients and considered due to trauma-related changes in the manubrio-sternal joint. The 3 patients who were not included in the study had no abnormalities of the sternum: 1 of them proved to have a well-healed sternal fracture and nonunion of a rib fracture, 1 had subtle Tietze's syndrome, and 1 patient revealed no pathological findings on imaging. Various factors may be responsible for prolonged sternal pain following thoracic trauma, and these can be viewed with MRI. In cases of sternal nonunion there was common fluid-like signal in the fracture interspace between the bony edges, and the bone marrow adjacent to the nonunion showed altered signal intensity. MRI identified sternal nonunion and other trauma-related abnormalities of the sternum following chest trauma. (orig.)
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The incidence of hyponatremia during prolonged ultraendurance exercise.
Noakes, T D; Norman, R J; Buck, R H; Godlonton, J; Stevenson, K; Pittaway, D
1990-04-01
Recent studies have shown that potentially fatal hyponatremia can develop during prolonged exercise. To determine the incidence of hyponatremia in athletes competing in ultradistance events, we measured serum sodium levels in 315 of 626 (50%) runners who were treated for collapse after two 90 km ultramarathon footraces (total starters 20,335; total finishers 18,031) and in 101 of 147 (69%) finishers in a 186 km ultratriathlon. In both races the athletes drank fluids with low sodium chloride content (less than 6.8 mmol.l-1). Hyponatremia (serum sodium level less than 130 mmol.l-1) was identified in 27 of 315 (9%) collapsed runners in the 90 km races and in none of the triathletes. In response to diuretic therapy, the runner with the most severe hyponatremia (serum sodium level = 112 mmol.l-1) excreted in excess of 7.5 l dilute urine during the first 17 h of hospitalization. These data suggest that, although symptomatic hyponatremia occurs in less than 0.3% of competitors during prolonged exercise even when they ingest little sodium chloride, it is found in a significant proportion (9%) of collapsed runners. A regulated contraction of the extracellular fluid volume would explain why the majority of athletes maintain normal serum sodium levels even though they develop a significant sodium chloride deficit during prolonged exercise. Alternatively, sodium chloride losses during prolonged exercise may be substantially less than are currently believed. Physicians treating collapsed ultradistance athletes need to be aware that as many as 10% or more of such patients may be hyponatremic.
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Prolonged sitting in cars: prevalence, socio-demographic variations, and trends.
Sugiyama, Takemi; Merom, Dafna; van der Ploeg, Hidde P; Corpuz, Grace; Bauman, Adrian; Owen, Neville
2012-10-01
Prolonged sitting is detrimentally associated with health outcomes. However, the prevalence and characteristics of those who sit in cars for long periods are not well understood. This study examined the population prevalence, socio-demographic variations, and trends for prolonged sitting in cars among adults. Using the Sydney Greater Metropolitan Area Household Travel Survey, the prevalence of prolonged sitting time in cars (≥2 h/day) was calculated for four 3-year periods (1997-99, 2000-02, 2003-05, and 2006-08) for each population subgroup. Trends were calculated as the mean change in prevalence between adjacent survey periods. Cars were used for 66% of the total trips recorded (n=336,505). The prevalence of prolonged sitting time in cars was 16-18% in men, and 10-12% in women. Relatively higher prevalence rates were found among middle-age groups (men: 20-22%, women: 12-15%), full-time workers (men: 21-24%, women: 14-15%), those with higher income (men: 21-25%, women: 14-16%), couples with children (men: 20-21%, women: 12-14%), and those living in outer suburbs (men: 20-23%, women: 12-13%). Trends were stable in men, but increasing in women. Several subgroups (older age; living in regional suburbs) also showed increasing trends. These findings provide evidence to inform integrated approaches to measurement and policy development on prolonged car use among the public health, urban planning, and transport sectors. Copyright © 2012 Elsevier Inc. All rights reserved.
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Management of children with prolonged diarrhea [version 1; referees: 3 approved
Directory of Open Access Journals (Sweden)
Antonietta Giannattasio
2016-02-01
Full Text Available Prolonged diarrhea is usually defined as acute-onset diarrhea lasting 7 days or more, but less than 14 days. Its trend has been declining in recent years because of improvement in the management of acute diarrhea, which represents the ideal strategy to prevent prolonged diarrhea. The pathogenesis of prolonged diarrhea is multifactorial and essentially based on persistent mucosal damage due to specific infections or sequential infections with different pathogens, host-related factors including micronutrient and/or vitamin deficiency, undernutrition and immunodeficiency, high mucosal permeability due to previous infectious processes and nutrient deficiency with consequential malabsorption, and microbiota disruption. Infections seem to play a major role in causing prolonged diarrhea in both developing and developed areas. However, single etiologic pathogens have not been identified, and the pattern of agents varies according to settings, host risk factors, and previous use of antibiotics and other drugs. The management of prolonged diarrhea is complex. Because of the wide etiologic spectrum, diagnostic algorithms should take into consideration the age of the patient, clinical and epidemiological factors, and the nutritional status and should always include a search for enteric pathogens. Often, expensive laboratory evaluations are of little benefit in guiding therapy, and an empirical approach may be effective in the majority of cases. The presence or absence of weight loss is crucial for driving the initial management of prolonged diarrhea. If there is no weight loss, generally there is no need for further evaluation. If weight loss is present, empiric anti-infectious therapy or elimination diet may be considered once specific etiologies have been excluded.
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Nuclear thermal rockets using indigenous extraterrestrial propellants
International Nuclear Information System (INIS)
Zubrin, R.M.
1990-01-01
A preliminary examination of a concept for a Mars and outer solar system exploratory vehicle is presented. Propulsion is provided by utilizing a nuclear thermal reactor to heat a propellant volatile indigenous to the destination world to form a high thrust rocket exhaust. Candidate propellants, whose performance, materials compatibility, and ease of acquisition are examined and include carbon dioxide, water, methane, nitrogen, carbon monoxide, and argon. Ballistics and winged supersonic configurations are discussed. It is shown that the use of this method of propulsion potentially offers high payoff to a manned Mars mission. This is accomplished by sharply reducing the initial mission mass required in low earth orbit, and by providing Mars explorers with greatly enhanced mobility in traveling about the planet through the use of a vehicle that can refuel itself each time it lands. Thus, the nuclear landing craft is utilized in combination with a hydrogen-fueled nuclear-thermal interplanetary launch. By utilizing such a system in the outer solar system, a low level aerial reconnaissance of Titan combined with a multiple sample return from nearly every satellite of Saturn can be accomplished in a single launch of a Titan 4 or the Space Transportation System (STS). Similarly a multiple sample return from Callisto, Ganymede, and Europa can also be accomplished in one launch of a Titan 4 or the STS
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Levofloxacin-Induced QTc Prolongation Depends on the Time of Drug Administration
Kervezee, L; Gotta, V; Stevens, J; Birkhoff, W; Kamerling, Imc; Danhof, M; Meijer, J H; Burggraaf, J
2016-01-01
Understanding the factors influencing a drug's potential to prolong the QTc interval on an electrocardiogram is essential for the correct evaluation of its safety profile. To explore the effect of dosing time on drug-induced QTc prolongation, a randomized, crossover, clinical trial was conducted in
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2008-01-01
The STEREO mission uses twin heliospheric orbiters to track solar disturbances from their initiation to 1 AU. This book documents the mission, its objectives, the spacecraft that execute it and the instruments that provide the measurements, both remote sensing and in situ. This mission promises to unlock many of the mysteries of how the Sun produces what has become to be known as space weather.
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Akapo, S. O.; Dimandja, J. M.; Kojiro, D. R.; Valentin, J. R.; Carle, G. C.
1999-01-01
Gas chromatography has proven to be a very useful analytical technique for in situ analysis of extraterrestrial environments as demonstrated by its successful operation on spacecraft missions to Mars and Venus. The technique is also one of the six scientific instruments aboard the Huygens probe to explore Titan's atmosphere and surface. A review of gas chromatography in previous space missions and some recent developments in the current environment of fiscal constraints and payload size limitations are presented.
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Variation in Definition of Prolonged Mechanical Ventilation.
Rose, Louise; McGinlay, Michael; Amin, Reshma; Burns, Karen Ea; Connolly, Bronwen; Hart, Nicholas; Jouvet, Philippe; Katz, Sherri; Leasa, David; Mawdsley, Cathy; McAuley, Danny F; Schultz, Marcus J; Blackwood, Bronagh
2017-10-01
Consistency of definitional criteria for terminology applied to describe subject cohorts receiving mechanical ventilation within ICU and post-acute care settings is important for understanding prevalence, risk stratification, effectiveness of interventions, and projections for resource allocation. Our objective was to quantify the application and definition of terms for prolonged mechanical ventilation. We conducted a scoping review of studies (all designs except single-case study) reporting a study population (adult and pediatric) using the term prolonged mechanical ventilation or a synonym. We screened 5,331 references, reviewed 539 full-text references, and excluded 120. Of the 419 studies (representing 38 countries) meeting inclusion criteria, 297 (71%) reported data on a heterogeneous subject cohort, and 66 (16%) included surgical subjects only (46 of those 66, 70% cardiac surgery). Other studies described COPD (16, 4%), trauma (22, 5%), neuromuscular (17, 4%), and sepsis (1, 0.2%) cohorts. A total of 741 terms were used to refer to the 419 study cohorts. The most common terms were: prolonged mechanical ventilation (253, 60%), admission to specialized unit (107, 26%), and long-term mechanical ventilation (79, 19%). Some authors (282, 67%) defined their cohorts based on duration of mechanical ventilation, with 154 studies (55%) using this as the sole criterion. We identified 37 different durations of ventilation ranging from 5 h to 1 y, with > 21 d being the most common (28 of 282, 7%). For studies describing a surgical cohort, minimum ventilation duration required for inclusion was ≥ 24 h for 20 of 66 studies (30%). More than half of all studies (237, 57%) did not provide a reason/rationale for definitional criteria used, with only 28 studies (7%) referring to a consensus definition. We conclude that substantial variation exists in the terminology and definitional criteria for cohorts of subjects receiving prolonged mechanical ventilation. Standardization of
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Acute Right Ventricular Dysfunction Complicating Prolonged ...
African Journals Online (AJOL)
We report a case of transient right ventricular dysfunction associated with prolonged cardiac tamponade, an unusual complication of uncertain etiology. We believe that in this case dynamic coronary flow restriction resulted in ischemic injury and stunning of the right ventricle. Other possible causes are briefly reviewed. Right ...
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The efficacy of antipsychotics for prolonged delirium with renal dysfunction
Directory of Open Access Journals (Sweden)
Asano S
2017-11-01
Full Text Available Satoko Asano, Yasuto Kunii, Hiroshi Hoshino, Yusuke Osakabe, Tetsuya Shiga, Shuntaro Itagaki, Itaru Miura, Hirooki Yabe Department of Neuropsychiatry, School of Medicine Fukushima Medical University, Fukushima, Japan Aim: Delirium is commonly encountered in daily clinical practice. To identify predictors influencing outcomes, we retrospectively examined the characteristics of inpatients with delirium who required psychiatric medication during hospitalization.Methods: We extracted all new inpatients (n=523 consulted for psychiatric symptoms at Fukushima Medical University Hospital between October 2011 and September 2013. We selected 203 inpatients with delirium diagnosed by psychiatrists. We analyzed data from 177 inpatients with delirium who received psychiatric medication. We defined an “early improvement group” in which delirium resolved in ≤3 days after starting psychiatric medication, and a “prolonged group” with delirium lasting for >3 days. Among the 83 inpatients with renal dysfunction (estimated glomerular filtration rate <60 mL/min/1.73 m2, we defined an “early improvement group with renal dysfunction” in which delirium resolved in ≤3 days after starting psychiatric medication and a “prolonged group with renal dysfunction” with delirium lasting for >3 days. We then examined differences between groups for different categorical variables.Results: Dose of antipsychotic medication at end point was significantly lower in the prolonged group with renal dysfunction than in the early improvement group with renal dysfunction.Conclusion: The results suggest that maintaining a sufficient dose of antipsychotics from an early stage may prevent prolongation of delirium even in inpatients with renal dysfunction. Keywords: antipsychotic, prolonged delirium, chronic kidney disease, pharmacokinetics
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Dynamics of heterogeneous liners with prolonged plasma creation
International Nuclear Information System (INIS)
Aleksandrov, V.V.; Branitskii, A.V.; Volkov, G.S.; Grabovskii, E.V.; Zurin, M.V.; Nedoseev, S.L.; Oleinik, G.M.; Samokhin, A.A.; Smirnov, V.P.; Fedulov, M.V.; Frolov, I.N.; Sasorov, P.V.
2001-01-01
Prolonged plasma creation in heterogeneous liners, in which the liner substance is separated into two phase states (a hot plasma and a cold skeleton), is investigated both experimentally and theoretically. This situation is typical of multiwire, foam, and even gas liners in high-current high-voltage facilities. The main mechanisms governing the rate at which the plasma is created are investigated, and the simplest estimates of the creation rate are presented. It is found that, during prolonged plasma creation, the electric current flows through the entire cross section of the produced plasma shell, whose thickness is comparable with the liner radius; in other words, a current skin layer does not form. During compression, such a shell is fairly stable because of its relatively high resilience. It is shown that, under certain conditions, even a thick plasma shell can be highly compressed toward the discharge axis. A simplified numerical simulation of the compression of a plasma shell in a liner with prolonged plasma creation is employed in order to determine the conditions for achieving regimes of fairly compact and relatively stable radial compression of the shell
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Severe bradycardia and prolonged hypotension in ciguatera.
Chan, Thomas Yan Keung
2013-06-01
Ciguatera results when ciguatoxin-contaminated coral reef fish from tropical or subtropical waters are consumed. The clinical features that present in affected persons are mainly gastrointestinal, neurological, general, and much less commonly, cardiovascular. We report the case of a 50-year-old man who developed the characteristic combination of acute gastrointestinal and neurological symptoms after the consumption of an unidentified coral reef fish head. In addition to those symptoms, he developed dizziness, severe bradycardia (46 bpm) and prolonged hypotension, which required the administration of intravenous atropine and over three days of intravenous fluid replacement with dopamine infusion. Patients with ciguatera can develop severe bradycardia and prolonged hypotension. Physicians should recognise the possible cardiovascular complications of ciguatera and promptly initiate treatment with intravenous atropine, intravenous fluid replacement and inotropic therapy if such complications are observed.
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Vision and Vestibular System Dysfunction Predicts Prolonged Concussion Recovery in Children.
Master, Christina L; Master, Stephen R; Wiebe, Douglas J; Storey, Eileen P; Lockyer, Julia E; Podolak, Olivia E; Grady, Matthew F
2018-03-01
Up to one-third of children with concussion have prolonged symptoms lasting beyond 4 weeks. Vision and vestibular dysfunction is common after concussion. It is unknown whether such dysfunction predicts prolonged recovery. We sought to determine which vision or vestibular problems predict prolonged recovery in children. A retrospective cohort of pediatric patients with concussion. A subspecialty pediatric concussion program. Four hundred thirty-two patient records were abstracted. Presence of vision or vestibular dysfunction upon presentation to the subspecialty concussion program. The main outcome of interest was time to clinical recovery, defined by discharge from clinical follow-up, including resolution of acute symptoms, resumption of normal physical and cognitive activity, and normalization of physical examination findings to functional levels. Study subjects were 5 to 18 years (median = 14). A total of 378 of 432 subjects (88%) presented with vision or vestibular problems. A history of motion sickness was associated with vestibular dysfunction. Younger age, public insurance, and presence of headache were associated with later presentation for subspecialty concussion care. Vision and vestibular problems were associated within distinct clusters. Provocable symptoms with vestibulo-ocular reflex (VOR) and smooth pursuits and abnormal balance and accommodative amplitude (AA) predicted prolonged recovery time. Vision and vestibular problems predict prolonged concussion recovery in children. A history of motion sickness may be an important premorbid factor. Public insurance status may represent problems with disparities in access to concussion care. Vision assessments in concussion must include smooth pursuits, saccades, near point of convergence (NPC), and accommodative amplitude (AA). A comprehensive, multidomain assessment is essential to predict prolonged recovery time and enable active intervention with specific school accommodations and targeted rehabilitation.
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Smoking prolongs the infectivity of patients with tuberculosis.
LENUS (Irish Health Repository)
Siddiqui, U A
2010-10-01
We sought to establish if smokers on anti-tuberculosis treatment are more likely to have a prolonged period of infectivity, compared to non-smoking tuberculosis patients, in a low tuberculosis prevalence country. We conducted a cross-sectional, retrospective study in Ireland that recruited 53 microbiologically confirmed cases of pulmonary tuberculosis (PTB). The age-sex adjusted odds ratios (AOR) suggest that the infectivity status of PTB on treatment was four times more likely to be prolonged beyond 6-8 weeks, if the cases had a smoking history (AOR: 4.42; 95% CI: 1.23; 15.9). Smoking was associated with delayed sputum smear conversion in PTB patients on treatment.
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Moroz, V.; Murdin, P.
2000-11-01
VEGA (mission) is a combined spacecraft mission to VENUS and COMET HALLEY. It was launched in the USSR at the end of 1984. The mission consisted of two identical spacecraft VEGA 1 and VEGA 2. VEGA is an acronym built from the words `Venus' and `Halley' (`Galley' in Russian spelling). The basic design of the spacecraft was the same as has been used many times to deliver Soviet landers and orbiter...
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Left Ventricular Function After Prolonged Exercise in Equine Endurance Athletes
DEFF Research Database (Denmark)
Flethøj, M.; Schwarzwald, C. C.; Haugaard, M. M.
2016-01-01
Doppler imaging, and two-dimensional speckle tracking. Correlation between echocardiographic variables and cardiac troponin I was evaluated. Results: Early diastolic myocardial velocities decreased significantly in longitudinal (baseline: −17.4 ± 2.4cm/s; end of ride: −15.8 ± 3.2cm/s (P = .013); morning......Background: Prolonged exercise in human athletes is associated with transient impairment of left ventricular (LV) function, known as cardiac fatigue. Cardiac effects of prolonged exercise in horses remain unknown. Objectives :To investigate the effects of prolonged exercise on LV systolic...... and diastolic function in horses. Animals: Twenty-six horses competing in 120–160 km endurance rides. Methods: Cross-sectional field study. Echocardiography was performed before and after rides, and the following morning, and included two-dimensional echocardiography, anatomical M-mode, pulsed-wave tissue...
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Bekaert, D. V.; Derenne, S.; Tissandier, L.; Marrocchi, Y.; Anquetil, C.; Marty, B.
2017-12-01
Organic matter (OM) synthesized from plasma experiments (so-called Nebulotron) can provide an insight into the processes of organosynthesis within the ionized gas phase of the protosolar nebula (PSN). Organic materials recovered from Nebulotron experiments have a record of success in reproducing key features of chondritic insoluble organic matter (IOM), including the aromatic/aliphatic and soluble/insoluble ratios [1], the occurrence of D/H hot and cold spots [2], spectral features as well as elementary and isotopic patterns observed in trapped noble gases [3]. However, up until now little attention has been paid to the soluble fraction of the recovered OM (SOM). In this study, a high-vacuum plasma setting was designed to produce organic condensates from a CO-N2-H2 gas mixture reminiscent of the PSN. The chemical diversity of the synthetized SOM has been investigated by gas chromatography - mass spectrometry. Our results show that a large range of biomolecules detected in meteorites and comets could have been directly synthetized from the gas phase of the PSN under high ionization rates and temperatures > 800 K. Among other molecules, urea, formamide, glycerol, hydantoin, carboxylic acids, as well as amino acid and nucleobase derivatives are reported. While photochemical processing of interstellar icy grains or asteroidal aqueous alteration are often advocated for the origin of biomolecules in extraterrestrial samples, our results suggest that biomolecule production was also effective in the hot and ionized photosphere of the PSN. Interestingly, solid-state 13C Nuclear Magnetic Resonance spectra of the Nebulotron IOM, indicates that they are very low in aromatics relative to extraterrestrial samples. Given that aromatic units in meteoritic IOM likely result from the cyclization/aromatization of aliphatic chains in the gas [1], Nebulotron-like aliphatic materials could represent the initial precursors of meteoritic OM [4]. These materials would be widespread in the
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Diet-consumer nitrogen isotope fractionation for prolonged fasting arthropods.
Mizota, Chitoshi; Yamanaka, Toshiro
2011-12-01
Nitrogen acquisition for cellular metabolism during diapause is a primary concern for herbivorous arthropods. Analyses of naturally occurring stable isotopes of nitrogen help elucidate the mechanism. Relevant articles have cited (58 times up to mid-June 2011) anomalously elevated δ(15)N (per mil deviation of (15)N/(14)N, relative to atmospheric nitrogen=0 ‰) values (diet-consumer nitrogen isotope fractionation; up to 12 ‰) for a prolonged fasting raspberry beetle (Byturus tomentosus Degeer (Coleoptera: Byturidae)), which feeds on red raspberries (Rubus idaeus: δ(15)N= ~ +2 ‰). Biologists have hypothesised that extensive recycling of amino acid nitrogen is responsible for the prolonged fasting. Since this hypothesis was proposed in 1995, scientists have integrated biochemical and molecular knowledge to support the mechanism of prolonged diapausing of animals. To test the validity of the recycling hypothesis, we analysed tissue nitrogen isotope ratios for four Japanese arthropods: the shield bug Parastrachia japonensis Scott (Hemiptera: Cydnidae), the burrower bug Canthophorus niveimarginatus Scott (Hemiptera: Cydnidae), leaf beetle Gastrophysa atrocyanea Motschulsky (Coleoptera: Chrysomelidae) and the Japanese oak silkworm Antheraea yamamai (Lepidoptera: Saturniidae), all of which fast for more than 6 months as part of their life-history strategy. Resulting diet-consumer nitrogen isotope discrimination during fasting ranged from 0 to 7‰, as in many commonly known terrestrial arthropods. We conclude that prolonged fasting of arthropods does not always result in anomalous diet-consumer nitrogen isotope fractionation, since the recycling process is closed or nearly closed with respect to nitrogen isotopes.
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Hyperglycemia and subsequent torsades de pointes with marked QT prolongation during refeeding.
Nakashima, Takashi; Kubota, Tomoki; Takasugi, Nobuhiro; Kitagawa, Yuichiro; Yoshida, Takahiro; Ushikoshi, Hiroaki; Kawasaki, Masanori; Nishigaki, Kazuhiko; Ogura, Shinji; Minatoguchi, Shinya
2017-01-01
A fatal cardiac complication can occasionally present in malnourished patients during refeeding; this is known as refeeding syndrome. However, to our knowledge, hyperglycemia preceding torsades de pointes with QT prolongation during refeeding has not been reported. In the present study, we present a case in which hyperglycemia preceded torsades de pointes with QT prolongation during refeeding. The aim of this study was to determine the possible mechanism underlying QT prolongation during refeeding and indicate how to prevent it. A 32-y-old severely malnourished woman (body mass index 14.57 kg/m 2 ) was admitted to the intensive care unit of our institution after resuscitation from cardiopulmonary arrest due to ventricular fibrillation. She was diagnosed with anorexia nervosa. Although no obvious electrolyte abnormalities were observed, her blood glucose level was 11 mg/dL. A 12-lead electrocardiogram at admission showed sinus rhythm with normal QT interval (QTc 0.448). Forty mL of 50% glucose (containing 20 g of glucose) was intravenously injected, followed by a drip infusion of glucose to maintain blood glucose level within normal range. After 9 h, the patient's blood glucose level increased to 569 mg/dL. However, after 38 h, an episode of marked QT prolongation (QTc 0.931) followed by torsades de pointes developed. Hyperglycemia during refeeding can present with QT prolongation; consequently, monitoring blood glucose levels may be useful in avoiding hyperglycemia, which can result in QT prolongation. Furthermore, additional monitoring of QT intervals using a 12-lead electrocardiogram should allow the early detection of QT prolongation when glucose solution is administered to a malnourished patient with (severe) hypoglycemia. Copyright © 2016 Elsevier Inc. All rights reserved.
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Surface biosignatures of exo-earths: remote detection of extraterrestrial life.
Hegde, Siddharth; Paulino-Lima, Ivan G; Kent, Ryan; Kaltenegger, Lisa; Rothschild, Lynn
2015-03-31
Exoplanet discovery has made remarkable progress, with the first rocky planets having been detected in the central star's liquid water habitable zone. The remote sensing techniques used to characterize such planets for potential habitability and life rely solely on our understanding of life on Earth. The vegetation red edge from terrestrial land plants is often used as a direct signature of life, but it occupies only a small niche in the environmental parameter space that binds life on present-day Earth and has been widespread for only about 460 My. To more fully exploit the diversity of the one example of life known, we measured the spectral characteristics of 137 microorganisms containing a range of pigments, including ones isolated from Earth's most extreme environments. Our database covers the visible and near-infrared to the short-wavelength infrared (0.35-2.5 µm) portions of the electromagnetic spectrum and is made freely available from biosignatures.astro.cornell.edu. Our results show how the reflectance properties are dominated by the absorption of light by pigments in the visible portion and by strong absorptions by the cellular water of hydration in the infrared (up to 2.5 µm) portion of the spectrum. Our spectral library provides a broader and more realistic guide based on Earth life for the search for surface features of extraterrestrial life. The library, when used as inputs for modeling disk-integrated spectra of exoplanets, in preparation for the next generation of space- and ground-based instruments, will increase the chances of detecting life.
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Prolonged parenteral nutrition after neonatal gastrointestinal surgery
DEFF Research Database (Denmark)
Estmann, Anne; Qvist, Niels; Husby, Steffen
2002-01-01
to diagnosis and clinical course. METHODOLOGY: This study reviews the clinical course of infants with gastrointestinal disease (gastroschisis, intestinal atresia, omphalocele, volvulus, Hirschsprung's disease and necrotizing enterocolitis) with a prolonged need for parenteral nutrition in the Western part...
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Prevention of Pazopanib-Induced Prolonged Cardiac Repolarization and Proarrhythmic Effects
Directory of Open Access Journals (Sweden)
Tulay Akman
2014-11-01
Full Text Available Background: Pazopanib (PZP may induce prolonged cardiac repolarization and proarrhythmic effects, similarly to other tyrosine kinase inhibitors. Objectives: To demonstrate PZP-induced prolonged cardiac repolarization and proarrhythmic electrophysiological effects and to investigate possible preventive effects of metoprolol and diltiazem on ECG changes (prolonged QT in an experimental rat model. Methods: Twenty-four Sprague-Dawley adult male rats were randomly assigned to 4 groups (n = 6. The first group (normal group received 4 mL of tap water and the other groups received 100 mg/kg of PZP (Votrient® tablet perorally, via orogastric tubes. After 3 hours, the following solutions were intraperitoneally administered to the animals: physiological saline solution (SP, to the normal group and to the second group (control-PZP+SP group; 1 mg/kg metoprolol (Beloc, Ampule, AstraZeneca, to the third group (PZP+metoprolol group; and 1mg/kg diltiazem (Diltiazem, Mustafa Nevzat, to the fourth group (PZP+diltiazem group. One hour after, and under anesthesia, QTc was calculated by recording ECG on lead I. Results: The mean QTc interval values were as follows: normal group, 99.93 ± 3.62 ms; control-PZP+SP group, 131.23 ± 12.21 ms; PZP+metoprolol group, 89.36 ± 3.61 ms; and PZP+diltiazem group, 88.86 ± 4.04 ms. Both PZP+metoprolol and PZP+diltiazem groups had significantly shorter QTc intervals compared to the control-PZP+SP group (p < 0.001. Conclusion: Both metoprolol and diltiazem prevented PZP-induced QT interval prolongation. These drugs may provide a promising prophylactic strategy for the prolonged QTc interval associated with tyrosine kinase inhibitor use.
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Parker Solar Probe: A NASA Mission to Touch the Sun: Mission Status Update
Fox, N. J.
2017-12-01
The newly renamed, Parker Solar Probe (PSP) mission will be the first mission to fly into the low solar corona, revealing how the corona is heated and the solar wind and energetic particles are accelerated, solving fundamental mysteries that have been top priority science goals since such a mission was first proposed in 1958. The scale and concept of such a mission has been revised at intervals since that time, yet the core has always been a close encounter with the Sun. The primary science goal of the Parker Solar Probe mission is to determine the structure and dynamics of the Sun's coronal magnetic field, understand how the solar corona and wind are heated and accelerated, and determine what mechanisms accelerate and transport energetic particles. PSP uses an innovative mission design, significant technology development and a risk-reducing engineering development to meet the science objectives. In this presentation, we provide an update on the progress of the Parker Solar Probe mission as we prepare for the July 2018 launch.
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Intrinsic motivation and amotivation in first episode and prolonged psychosis.
Luther, Lauren; Lysaker, Paul H; Firmin, Ruth L; Breier, Alan; Vohs, Jenifer L
2015-12-01
The deleterious functional implications of motivation deficits in psychosis have generated interest in examining dimensions of the construct. However, there remains a paucity of data regarding whether dimensions of motivation differ over the course of psychosis. Therefore, this study examined two motivation dimensions, trait-like intrinsic motivation, and the negative symptom of amotivation, and tested the impact of illness phase on the 1) levels of these dimensions and 2) relationship between these dimensions. Participants with first episode psychosis (FEP; n=40) and prolonged psychosis (n=66) completed clinician-rated measures of intrinsic motivation and amotivation. Analyses revealed that when controlling for group differences in gender and education, the FEP group had significantly more intrinsic motivation and lower amotivation than the prolonged psychosis group. Moreover, intrinsic motivation was negatively correlated with amotivation in both FEP and prolonged psychosis, but the magnitude of the relationship did not statistically differ between groups. These findings suggest that motivation deficits are more severe later in the course of psychosis and that low intrinsic motivation may be partially independent of amotivation in both first episode and prolonged psychosis. Clinically, these results highlight the importance of targeting motivation in early intervention services. Copyright © 2015 Elsevier B.V. All rights reserved.
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Safety and tolerability of prolonged-release nicotinic acid in statin-treated patients
Birjmohun, R. S.; Kastelein, J. J. P.; Poldermans, D.; Stroes, E. S. G.; Hostalek, U.; Assmann, G.
2007-01-01
Objective: To evaluate the safety and tolerability of prolonged -release nicotinic acid (Niaspan*) added to statin therapy in patients at increased cardiovascular risk. Methods: This was a 6-month, prospective, observational, multicentre, open-label evaluation of prolonged-release nicotinic acid
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Mesenteric venous thrombosis after prolonged air travel-a case report
Directory of Open Access Journals (Sweden)
Joaquín Salas-Coronas
2014-07-01
Full Text Available We present a case of acute mesenteric venous thrombosis after a long distance flight in a traveller presenting with abdominal pain, diarrhoea and vomiting within 48 h of prolonged immobility situation. Venous thrombosis in the lower limbs and venous thromboembolism has been clearly associated with prolonged air travel (economy class syndrome. Thrombosis was diagnosed by computed tomography of the abdomen, and after starting anticoagulant therapy with acenocumarol, symptoms yielded completely in a few weeks. The study of thrombophilia was negative, although the existence of two first-degree relatives (mother and grandmother with a history of venous thrombosis with a history of venous thrombosis makes it likely a situation of inherited thrombophilia. Although exceptional, mesenteric venous thrombosis should be considered in travellers with acute abdominal pain after prolonged air travel when there are thrombophilic conditions.
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Laryngotracheal Injury following Prolonged Endotracheal Intubation
Directory of Open Access Journals (Sweden)
J. Mehdizadeh
2006-07-01
Full Text Available Background: Prolonged endotracheal intubation is a growing method for supporting ventilation in patients who require intensive care. Despite considerable advancement in endotracheal intubation, this method still has some complications; the most important is laryngo-tracheal injuries. Methods: Over a 2-year period, this retrospective study was conducted on 57 patients with history of prolonged intubation who were referred to the ENT Department of Amir Alam Hospital. For each patient, a complete evaluation including history, physical examination, and direct laryngoscopy and bronchoscopy was done under general anesthesia. Results: Fifty-seven patients (44 male; mean age, 23.014.7 years were studied. Mean intubation period was 15.88 days. The most common presenting symptom was dyspnea (62%. Head trauma was responsible for most cases of intubation (72.4%. The most common types of tracheal and laryngeal lesions were tracheal (56.9% and subglottic (55.2% stenosis, respectively. Mean length of tracheal stenosis was 0.810.83 cm. There was a statistically significant relationship between length of tracheal stenosis and intubation period (P=0.0001 but no relation was observed between tracheal stenosis and age, sex, and etiology of intubation (All P=NS. Among the glottic lesions, inter- arytenoids adhesion was the most common lesion (25.9%. No statistically significant relation was found between glottic and subglottic lesions and age, sex and intubation period (all P=NS. Length of stenosis and intubation period was significantly greater in tracheal/ subglottic lesions than those in glottic/ supraglottic lesions (all P=NS. Conclusion: After prolonged endotracheal intubation, laryngo-tracheal lesions had no relation with patient’s age, sex, and cause of intubation.There was direct relation between length of tracheal stenosis and intubation period. Glottic lesions were more commonly observed in head trauma patients. Lesion length and intubation
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Nystedt, Astrid; Hildingsson, Ingegerd
2014-01-01
Background: Prolonged labour very often causes suffering from difficulties that may have lifelong implications. This study aimed to explore the prevalence and treatment of prolonged labour and to compare birth outcome and women's experiences of prolonged and normal labour. Method: Women with spontaneous onset of labour, living in a Swedish county, were recruited two months after birth, to a cross-sectional study. Women (n = 829) completed a questionnaire that investigated socio-demographic an...
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Grading of Emphysema Is Indispensable for Predicting Prolonged Air Leak After Lung Lobectomy.
Murakami, Junichi; Ueda, Kazuhiro; Tanaka, Toshiki; Kobayashi, Taiga; Hamano, Kimikazu
2018-04-01
The aim of this study was to assess the utility of quantitative computed tomography-based grading of emphysema for predicting prolonged air leak after thoracoscopic lobectomy. A consecutive series of 284 patients undergoing thoracoscopic lobectomy for lung cancer was retrospectively reviewed. Prolonged air leak was defined as air leaks lasting 7 days or longer. The grade of emphysema (emphysema index) was defined by the proportion of the emphysematous lung volume (less than -910 HU) to the total lung volume (-600 to -1,024 HU) by a computer-assisted histogram analysis of whole-lung computed tomography scans. The mean length of chest tube drainage was 1.5 days. Fifteen patients (5.3%) presented with prolonged air leak. According to a receiver-operating characteristics curve analysis, the emphysema index was the best predictor of prolonged air leak, with an area under the curve of 0.85 (95% confidence interval: 0.73 to 0.98). An emphysema index of 35% or greater was the best cutoff value for predicting prolonged air leak, with a negative predictive value of 0.99. The emphysema index was the only significant predictor for the length of postoperative chest tube drainage among conventional variables, including the pulmonary function and resected lobe, in both univariate and multivariate analyses. Prolonged air leak resulted in an increased duration of hospitalization (p leak that adversely influences early postoperative outcomes. We must take new measures against prolonged air leak in quantitative computed tomography-based high-risk patients. Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
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Prolonged Mechanical Ventilation as a Predictor of Mortality After Cardiac Surgery.
Fernandez-Zamora, Maria Dolores; Gordillo-Brenes, Antonio; Banderas-Bravo, Esther; Arboleda-Sánchez, José Andrés; Hinojosa-Pérez, Rafael; Aguilar-Alonso, Eduardo; Herruzo-Aviles, Ángel; Curiel-Balsera, Emilio; Sánchez-Rodríguez, Ángel; Rivera-Fernández, Ricardo
2018-05-01
Mortality among the small percentage of cardiac surgery patients receiving prolonged mechanical ventilation is high, but this issue appears to be inadequately addressed in guidelines. This study is a retrospective analysis of prospective, multi-center, and observational study in Spain including all adults undergoing cardiac surgery in 3 Andalusian hospitals between June 2008 and December 2012. The study included 3,588 adults with mean ± SD age of 63.5 ± 12.8 y and with median (interquartile range) EuroSCORE of 5 (3-7) points. Prolonged mechanical ventilation (> 24 h) was required by 415 subjects (11.6%), with ICU mortality of 44.3% (184 subjects), and was not required by 3,173 subjects (88.4%), with ICU mortality of 3.1% (99 subjects, P mechanical ventilation was associated with more complications and was required by 4.5% of subjects with a EuroSCORE 10. In the multivariable analysis, ICU mortality was associated with illness severity, duration of bypass surgery, surgery type, and prolonged mechanical ventilation (odds ratio 15.19, 95% CI 11.56-22.09). The main cause of death was multiple organ failure and sepsis in subjects who required prolonged mechanical ventilation (50.3%) and cardiogenic shock in those who did not (59.2%). Prolonged postoperative mechanical ventilation was required by 10-20% of cardiac surgery subjects, who constitute a specific group that represents most of the postoperative mortality, which is associated with multiple organ failure and sepsis. Copyright © 2018 by Daedalus Enterprises.
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Directory of Open Access Journals (Sweden)
O.V. Tyajka
2016-11-01
Full Text Available Background. Neonatal jaundice is one of the urgent problems in neonatology. There is a tendency to increase the incidence of prolonged jaundice. The aim of our study was to explore the features of history, anthropometric data and some liver functions in children with prolonged jaundice. Materials and methods. The study involved 111 children with prolonged jaundice aged from 3 weeks to 3 months. In all children with prolonged jaundice, we have examined complete blood count, urinalysis, blood chemistry (determination of total bilirubin and fractions, total protein, albumin, glucose and used instrumental methods of examination — ultrasound of the abdominal cavity and cranial ultrasonography, electrocardiography. Most children with prolonged jaundice were breastfed and were term infants. Results. Indicators of physical development at birth (body weight, body length, head circumference, chest circumference in children with prolonged jaundice and in healthy children had not statistically significant differences. Neonatal jaundice was prolonged in children, who were born from the first pregnancy, — 60 children (54.1 %. A high level of total and indirect bilirubin was accompanied by a low level of albumin in the blood serum of children with prolonged jaundice. Protein-synthesis function of the liver was reduced in children with prolonged jaundice.
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Jamieson, C. S.; Guo, Y.; Gu, X.; Zhang, F.; Bennett, C. J.; Kaiser, R. I.
2006-01-01
A detailed knowledge of the formation of carbon-bearing molecules in interstellar ices and in the gas phase of the interstellar medium is of paramount interest to understand the astrochemical evolution of extraterrestrial environments (1). This research also holds strong implications to comprehend the chemical processing of Solar System environments such as icy planets and their moons together with the atmospheres of planets and their satellites (2). Since the present composition of each interstellar and Solar System environment reflects the matter from which it was formed and the processes which have changed the chemical nature since the origin (solar wind, planetary magnetospheres, cosmic ray exposure, photolysis, chemical reactions), a detailed investigation of the physicochemical mechanisms altering the pristine environment is of paramount importance to grasp the contemporary composition. Once these underlying processes have been unraveled, we can identify those molecules, which belonged to the nascent setting, distinguish molecular species synthesized in a later stage, and predict the imminent chemical evolution of, for instance, molecular clouds. Laboratory experiments under controlled physicochemical conditions (temperature, pressure, chemical composition, high energy components) present ideal tools for simulating the chemical evolution of interstellar and Solar System environments. Here, laboratory experiments can predict where and how (reaction mechanisms; chemicals necessary) in extraterrestrial environments and in the interstellar medium complex, carbon bearing molecules can be formed on interstellar grains and in the gas phase. This paper overviews the experimental setups utilized in our laboratory to mimic the chemical processing of gas phase and solid state (ices) environments. These are a crossed molecular beams machine (3) and a surface scattering setup (4). We also present typical results of each setup (formation of amino acids, aldehydes, epoxides
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Logistics Needs for Potential Deep Space Mission Scenarios Post Asteroid Redirect Crewed Mission
Lopez, Pedro, Jr.; Shultz, Eric; Mattfeld, Bryan; Stromgren, Chel; Goodliff, Kandyce
2015-01-01
The Asteroid Redirect Mission (ARM) is currently being explored as the next step towards deep space human exploration, with the ultimate goal of reaching Mars. NASA is currently investigating a number of potential human exploration missions, which will progressively increase the distance and duration that humans spend away from Earth. Missions include extended human exploration in cis-lunar space which, as conceived, would involve durations of around 60 days, and human missions to Mars, which are anticipated to be as long as 1000 days. The amount of logistics required to keep the crew alive and healthy for these missions is significant. It is therefore important that the design and planning for these missions include accurate estimates of logistics requirements. This paper provides a description of a process and calculations used to estimate mass and volume requirements for crew logistics, including consumables, such as food, personal items, gasses, and liquids. Determination of logistics requirements is based on crew size, mission duration, and the degree of closure of the environmental control life support system (ECLSS). Details are provided on the consumption rates for different types of logistics and how those rates were established. Results for potential mission scenarios are presented, including a breakdown of mass and volume drivers. Opportunities for mass and volume reduction are identified, along with potential threats that could possibly increase requirements.
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Prolonged Cholestatic Jaundice Associated With Flurbiprofen.
Dogan, Serkan; Celikbilek, Mehmet; Demirkan, Kutay; Yilmaz, Semih; Deniz, Kemal; Gursoy, Sebnem; Yucesoy, Mehmet
2014-08-01
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely consumed drugs throughout the world for pain relief. Although the adverse effects of NSAIDs to the liver are well known, flurbiprofen-induced liver cholestasis is extremely rare. Herein, we present a patient with prolonged icterus that is associated with the use of flurbiprofen without causing ductopenia. © The Author(s) 2013.
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Cheng, Min; Lu, Xiangfeng; Huang, Jianfeng; Zhang, Shu; Gu, Dongfeng
2015-01-01
Electrocardiographic PR interval prolongation is considered a benign condition, but recent studies have challenged the notion by demonstrating that prolonged PR interval is associated with an increased risk of atrial fibrillation (AF). The purpose of this study was to perform a meta-analysis of prospective cohort studies to evaluate the evidence supporting an association of prolonged PR interval with AF incidence. We searched the MEDLINE and EMBASE database (from inception to May 2014) supplemented by manual searches of references of relevant retrieved articles. Prospective cohort studies were included with hazard ratio (HR) of prolonged PR interval for incident AF. The search strategy yielded 6 cohort studies meeting eligibility criteria. A total of 328,932 participants were included, with 14,191 participants suffering from AF during follow-up. Pooled HRs of prolonged PR interval for incident AF was 1.30 (95% CI: 1.13 to 1.49) using random-effect model (I(2) = 30%). There was a significant difference of combined HRs between studies with and without adjustment for taking of AV nodal blocking agents in subgroup analysis. Sensitivity analysis supported the robustness of the results. Prolonged PR interval is not a totally benign condition but an independent risk factor for AF incidence. The mechanisms underlying the association of prolonged PR interval with AF incidence need further research. © 2014 Wiley Periodicals, Inc.
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High frequency components of tracheal sound are emphasized during prolonged flow limitation
International Nuclear Information System (INIS)
Tenhunen, M; Huupponen, E; Saastamoinen, A; Kulkas, A; Himanen, S-L; Rauhala, E
2009-01-01
A nasal pressure transducer, which is used to study nocturnal airflow, also provides information about the inspiratory flow waveform. A round flow shape is presented during normal breathing. A flattened, non-round shape is found during hypopneas and it can also appear in prolonged episodes. The significance of this prolonged flow limitation is still not established. A tracheal sound spectrum has been analyzed further in order to achieve additional information about breathing during sleep. Increased sound frequencies over 500 Hz have been connected to obstruction of the upper airway. The aim of the present study was to examine the tracheal sound signal content of prolonged flow limitation and to find out whether prolonged flow limitation would consist of abundant high frequency activity. Sleep recordings of 36 consecutive patients were examined. The tracheal sound spectral analysis was performed on 10 min episodes of prolonged flow limitation, normal breathing and periodic apnea-hypopnea breathing. The highest total spectral amplitude, implicating loudest sounds, occurred during flow-limited breathing which also presented loudest sounds in all frequency bands above 100 Hz. In addition, the tracheal sound signal during flow-limited breathing constituted proportionally more high frequency activities compared to normal breathing and even periodic apnea-hypopnea breathing
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Braslavsky, D; Keselman, A; Chiesa, A; Bergadá, I
2012-03-01
The association of prolonged neonatal jaundice and hypoglycaemia may be secondary to an endocrinological disease. Pituitary insufficiency and primary adrenal insufficiency are the most likely endocrine diseases that need to be ruled out. We retrospectively analysed the clinical and laboratory characteristics of thirteen patients referred to the Hospital de Niños Ricardo Gutiérrez between years 2003 and 2008 due to prolonged neonatal jaundice and hypoglycaemia secondary to pituitary insufficiency in twelve patients, and in one secondary to primary adrenal insufficiency. All patients had a history of neonatal hypoglycaemia. Ten patients had conjugated hyperbilirubinaemia and six also had elevated transaminases. Combined pituitary hormone deficiency was observed in the twelve hypopituitarism patients. Hormonal replacement normalised liver function and resolved the prolonged jaundice in all the patients. None of them underwent liver biopsy. Hypoglycaemia also remitted after hormonal therapy. Prolonged or cholestatic jaundice associated with neonatal hypoglycaemia is highly likely to be due to pituitary hormone deficiency or primary adrenal insufficiency. Early diagnosis and treatment of these children reverts the prolonged jaundice and prevents morbidity and mortality due to recurrent hypoglycaemia and hormone deficiencies. Copyright © 2011 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.
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Qt interval prolongation and ventricular arrhythmias in patients with chronic heart failure
International Nuclear Information System (INIS)
Sarwar, M.; Majeed, S.M.I.; Khan, M.A.; Majeed, S.M.
2014-01-01
To determine the association of QTc interval prolongation with ventricular arrhythmias in patients with chronic heart failure. Study Design: Descriptive study. Place and Duration of Study: This study was conducted at Armed Forces Institute of Cardiology/National Institute of Heart Diseases, Rawalpindi, Pakistan from April 2013 to August 2013. Patients and Methods: Fifty three heart failure patients were monitored for 48 hours using ambulatory holter electrocardiography recorders. Digital ECG data was analyzed for QTc interval along with frequency and severity of arrhythmias. Association of prolonged QTc interval with ventricular arrhythmias and severity of arrhythmias was analyzed. Results: Cardiac arrhythmias were observed in 79.2% patients. QT analysis revealed that 69.8% patients had prolonged QTc interval, 86.4% patients with prolonged QTc had ventricular arrhythmias. Of these 66% patients were found to have severe ventricular arrhythmias. Comparison of mean QTc interval of our study population with a reference value showed significantly higher QTc interval of our study group than the test value. Conclusion: Arrhythmia frequency and severity significantly increases with an increase in QTc interval in heart failure demonstrating association of prolonged QTc interval with high risk of severe ventricular arrhythmias and sudden cardiac death in chronic heart failure. (author)
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MoonNEXT: A European Mission to the Moon
Carpenter, J. D.; Koschny, D.; Crawford, I.; Falcke, H.; Kempf, S.; Lognonne, P.; Ricci, C.; Houdou, B.; Pradier, A.
2008-09-01
MoonNEXT is a mission currently being studied, under the direction of the European Space Agency, whose launch is foreseen between 2015 and 2018. MoonNEXT is intended to prepare the way for future exploration activities on the Moon, while addressing key science questions. Exploration Objectives The primary goal for the MoonNEXT mission is to demonstrate autonomous soft precision landing with hazard avoidance; a key capability for future exploration missions. The nominal landing site is at the South Pole of the Moon, at the edge of the Aitken basin and in the region of Shackleton crater, which has been identified as an optimal location for a future human outpost by the NASA lunar architecture team [1]. This landing site selection ensures a valuable contribution by MoonNEXT to the Global Exploration Strategy [2]. MoonNEXT will also prepare for future lunar exploration activities by characterising the environment at the lunar surface. The potentially hazardous radiation environment will me monitored while a dedicated instrument package will investigate the levitation and mobility of lunar dust. Experience on Apollo demonstrated the potentially hazardous effects of dust for surface operations and human activities and so an understanding of these processes is important for the future. Life sciences investigations will be carried out into the effects of the lunar environment (including radiation, gravity and illumination conditions) on a man made ecosystem analogous to future life support systems. In doing so MoonNEXT will demonstrate the first extraterrestrial man made ecosystem and develop valuable expertise for future missions. Geological and geochemical investigations will explore the possibilities for In Situ Resource Utilisation (ISRU), which will be essential for long term human habitation on the Moon and is of particular importance at the proposed landing site, given its potential as a future habitat location. Science Objectives In addition to providing extensive
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End of mission report on seismic safety review mission for Belene NPP site
International Nuclear Information System (INIS)
Gurpinar, A.; Mohammadioun, B.; Schneider, H.; Serva, L.
1995-01-01
Upon the invitation of the Bulgarian government through the Committee for the Peaceful Uses of Atomic Energy and within the framework of the implementation of the Technical Cooperation project BUL/9/012 related to site and seismic of NPPs, a mission visited Sofia 3 - 7 July 1995. The mission constituted a follow-up of the interim review of subjects related to tectonic stability and seismic hazard characterization of the site which was performed in September 1993. The main objective of the mission was the final review of the subjects already reviewed in September 1993 as well as issues related to geotechnical engineering and foundation safety. The main terms of reference of the present mission was to verify the implementation of the recommendations of the Site Safety Review Mission of June 1990. This document gives findings on geology-tectonics, seismology and foundation safety. In the end conclusions and recommendations of the mission are presented
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Prolonged displacement may compromise resilience in Eritrean ...
African Journals Online (AJOL)
Objective: to assess the impact of prolonged displacement on the resilience of Eritrean mothers. Methods: an adapted SOC scale (short form) was administered. Complementary qualitative data were gathered from study participants' spontaneous reactions to and commentaries on the SOC scale. Results: Displaced ...
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B plant mission analysis report
International Nuclear Information System (INIS)
Lund, D.P.
1995-01-01
This report further develops the mission for B Plant originally defined in WHC-EP-0722, ''System Engineering Functions and Requirements for the Hanford Cleanup Mission: First Issue.'' The B Plant mission analysis will be the basis for a functional analysis that breaks down the B Plant mission statement into the necessary activities to accomplish the mission. These activities are the product of the functional analysis and will then be used in subsequent steps of the systems engineering process, such as identifying requirements and allocating those requirements to B Plant functions. The information in this mission analysis and the functional and requirements analysis are a part of the B Plant technical baseline
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Titov, D. V.; Baines, K. H.; Basilevsky, A. T.; Chassefiere, E.; Chin, G.; Crisp, D.; Esposito, L. W.; Lebreton, J.-P.; Lellouch, E.; Moroz, V. I.; Nagy, A. F.; Owen, T. C.; Oyama, K.-I.; Russell, C. T.; Taylor, F. W.; Young, R. E.
2002-10-01
Venus has always been a fascinating objective for planetary studies. At the beginning of the space era Venus became one of the first targets for spacecraft missions. Our neighbour in the solar system and, in size, the twin sister of Earth, Venus was expected to be very similar to our planet. However, the first phase of Venus spacecraft exploration in 1962-1992 by the family of Soviet Venera and Vega spacecraft and US Mariner, Pioneer Venus, and Magellan missions discovered an entirely different, exotic world hidden behind a curtain of dense clouds. These studies gave us a basic knowledge of the conditions on the planet, but generated many more questions concerning the atmospheric composition, chemistry, structure, dynamics, surface-atmosphere interactions, atmospheric and geological evolution, and the plasma environment. Despite all of this exploration by more than 20 spacecraft, the "morning star" still remains a mysterious world. But for more than a decade Venus has been a "forgotten" planet with no new missions featuring in the plans of the world space agencies. Now we are witnessing the revival of interest in this planet: the Venus Orbiter mission is approved in Japan, Venus Express - a European orbiter mission - has successfully passed the selection procedure in ESA, and several Venus Discovery proposals are knocking at the doors of NASA. The paper presents an exciting story of Venus spacecraft exploration, summarizes open scientific problems, and builds a bridge to the future missions.
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High frequency of pertussis in older children and adolescents with prolonged cough in Turkey.
Aslan, Aslı; Kurugöl, Zafer; Aydemir, Şöhret; Gürsel, Derya; Koturoğlu, Güldane
2016-01-01
This study aimed to determine the frequency of B. pertussis infection among Turkish children with prolonged cough. Nasopharyngeal specimens were collected from 7-18 year old children, presenting with prolonged cough of two to four weeks' duration. Specimens were examined for B. pertussis by PCR. Of 101 children with prolonged cough, 20 (19.8%) had a positive PCR testing for B. pertussis. Children who were vaccinated ≥5 years previously had a 6.13-fold higher risk of PCR-confirmed pertussis than those who were vaccinated pertussis (paroxysmal cough, whooping and post-tussive vomiting) were seen in 30%, 15% and 25% of the patients with positive PCR, respectively; 55% of them had only a prolonged cough without any classic symptoms. Pertussis is common among Turkish children with prolonged cough, even after implementation of a fifth dose of pertussis vaccination and despite high vaccination coverage.
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Ways to Optimize Therapy of Prolonged Conjugation Jaundice in Infants
Directory of Open Access Journals (Sweden)
O.G. Shadrin
2015-09-01
Full Text Available The article is devoted to the optimization of the treatment of prolonged conjugation jaundice. Inclusion of ursodeoxycholic acid in the treatment of neonatal prolonged conjugation jaundice in a dose of 15–20 mg/kg of body mass per day increases the terms of regression of clinical and paraclinical signs of jaundice as much as 2 times and leads to cytolysis normalization. The preparation has a sufficient level of safety, there were not revealed side effects whilst its application.
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Are shame and self-esteem risk factors in prolonged grief after death of a spouse?
Dellmann, Thomas
2018-07-01
Although many single factors of prolonged grief have been identified in the literature, a comprehensive understanding of predictors is still lacking. This article argues that shame and low self-esteem, present risk factors in prolonged grief after spousal loss, based on a review of correlational studies. Using a practitioner-scientist approach, a developmental model of shame as a core factor in prolonged grief is proposed, outlining the progression from childhood relational trauma, to insecure attachment, shame, self-esteem contingent on spousal approval to eventual prolonged grief.
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Hippocampal Abnormalities after Prolonged Febrile Convulsions
Directory of Open Access Journals (Sweden)
J Gordon Millichap
2003-11-01
Full Text Available Hippocampal volume and T2 relaxation times were determined in an MRI study of 14 children with prolonged febrile convulsions (PFC who were investigated, 1 within 5 days of a PFC, and 2 at follow-up 4-8 months after the acute study, at the Institute of Child Health, University College, and Great Ormond Street Hospital, London, UK.
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Teaching Planetary Science as Part of the Search for Extraterrestrial Intelligence (SETI)
Margot, Jean-Luc; Greenberg, Adam H.
2017-10-01
In Spring 2016 and 2017, UCLA offered a course titled "EPSS C179/279 - Search for Extraterrestrial Intelligence: Theory and Applications". The course is designed for advanced undergraduate students and graduate students in the science, technical, engineering, and mathematical fields. Each year, students designed an observing sequence for the Green Bank telescope, observed known planetary systems remotely, wrote a sophisticated and modular data processing pipeline, analyzed the data, and presented their results. In 2016, 15 students participated in the course (9U, 5G; 11M, 3F) and observed 14 planetary systems in the Kepler field. In 2017, 17 students participated (15U, 2G; 10M, 7F) and observed 10 planetary systems in the Kepler field, TRAPPIST-1, and LHS 1140. In order to select suitable targets, students learned about planetary systems, planetary habitability, and planetary dynamics. In addition to planetary science fundamentals, students learned radio astronomy fundamentals, collaborative software development, signal processing techniques, and statistics. Evaluations indicate that the course is challenging but that students are eager to learn because of the engrossing nature of SETI. Students particularly value the teamwork approach, the observing experience, and working with their own data. The next offering of the course will be in Spring 2018. Additional information about our SETI work is available at seti.ucla.edu.
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Solar Probe Plus: A NASA Mission to Touch the SunMission Status Update
Fox, N. J.
2016-12-01
Solar Probe Plus (SPP), currently in Phase D, will be the first mission to fly into the low solar corona, revealing how the corona is heated and the solar wind and energetic particles are accelerated, solving fundamental mysteries that have been top priority science goals since such a mission was first proposed in 1958. The scale and concept of such a mission has been revised at intervals since that time, yet the core has always been a close encounter with the Sun. The primary science goal of the Solar Probe Plus mission is to determine the structure and dynamics of the Sun's coronal magnetic field, understand how the solar corona and wind are heated and accelerated, and determine what mechanisms accelerate and transport energetic particles. SPP uses an innovative mission design, significant technology development and a risk-reducing engineering development to meet the SPP science objectives. In this presentation, we provide an update on the progress of the Solar Probe Plus mission as we prepare for the July 2018 launch.
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Ageing is associated with a prolonged fever response in human endotoxemia
DEFF Research Database (Denmark)
Krabbe, Karen S.; Kemp Bruunsgaard, Helle; Hansen, Christian Muff
2017-01-01
The purpose of this study was to investigate whether an age-associated impaired acute-phase response exists. Nine healthy elderly volunteers (median, 66 years; range, 61 to 69 years) and eight young controls (median, 24 years; range, 20 to 27 years) were given an intravenous bolus of endotoxin (2......-alpha and sTNFR-I levels and prolonged increased levels of sTNFR-I. Monocyte concentrations decreased in both groups, with the elderly group showing a more rapid decrease and a slower subsequent increase than did the young group. Furthermore, the elderly group had a more rapid increase in C-reactive protein...... levels than did the young group. In conclusion, ageing is associated with an altered acute-phase response including initial hyperreactivity, prolonged inflammatory activity, and prolonged fever response....
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The effects of sodium bicarbonate during prolonged cardiopulmonary resuscitation.
Weng, Yi-Ming; Wu, Shih-Hao; Li, Wen-Cheng; Kuo, Chan-Wei; Chen, Shou-Yen; Chen, Jih-Chang
2013-03-01
This study was performed to determine the effects of sodium bicarbonate injection during prolonged cardiopulmonary resuscitation (for >15 minutes). The retrospective cohort study consisted of adult patients who presented to the emergency department (ED) with the diagnosis of cardiac arrest in 2009. Data were retrieved from the institutional database. A total of 92 patients were enrolled in the study. Patients were divided into 2 groups based on whether they were treated (group1, n = 30) or not treated (group 2, n = 62) with sodium bicarbonate. There were no significant differences in demographic characteristics between groups. The median time interval between the administration of CPR and sodium bicarbonate injection was 36.0 minutes (IQR: 30.5-41.8 minutes). The median amount of bicarbonate injection was 100.2 mEq (IQR: 66.8-104.4). Patients who received a sodium bicarbonate injection during prolonged CPR had a higher percentage of return of spontaneous circulation, but not statistical significant (ROSC, 40.0% vs. 32.3%; P = .465). Sustained ROSC was achieved by 2 (6.7%) patients in the sodium bicarbonate treatment group, with no survival to discharge. No significant differences in vital signs after ROSC were detected between the 2 groups (heart rate, P = .124; systolic blood pressure, P = .094). Sodium bicarbonate injection during prolonged CPR was not associated with ROSC after adjust for variables by regression analysis (Table 3; P = .615; odds ratio, 1.270; 95% confidence interval: 0.501-3.219) The administration of sodium bicarbonate during prolonged CPR did not significantly improve the rate of ROSC in out-of-hospital cardiac arrest. Copyright © 2013 Elsevier Inc. All rights reserved.
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Primiparous women's preferences for care during a prolonged latent phase of labour.
Ängeby, Karin; Wilde-Larsson, Bodil; Hildingsson, Ingegerd; Sandin-Bojö, Ann-Kristin
2015-10-01
To investigate primiparous women's preferences for care during a prolonged latent phase of labour. A qualitative study based on focus groups and individual interviews and analysed with inductive content analysis. Sixteen primiparous women with a prolonged latent phase of labour >18 hours were interviewed in five focus groups (n = 11) or individually (n = 5). One main category emerged "Beyond normality - a need of individual adapted guidance in order to understand and manage an extended latent phase of labour" which covers the women's preferences during the prolonged latent phase. Five categories were generated from the data: "A welcoming manner and not being rejected", "Individually adapted care", "Important information which prepares for reality and coping", "Participation and need for feedback" and "Staying nearby the labour ward or being admitted for midwifery support". Women with a prolonged latent phase of labour sought to use their own resources, but their needs for professional support increased as time passed. A welcoming attitude from an available midwife during the latent phase created a feeling of security, and personally adapted care was perceived positively. Women with a prolonged latent phase of labour preferred woman-centred care. Midwives play an important role in supporting these women. Women's need for midwifery-support increases as the time spent in latent phase increases. Copyright © 2015 Elsevier B.V. All rights reserved.
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The Messenger Mission to Mercury
Domingue, D. L
2007-01-01
NASA’s MESSENGER mission, launched on 3 August, 2004 is the seventh mission in the Discovery series. MESSENGER encounters the planet Mercury four times, culminating with an insertion into orbit on 18 March 2011. It carries a comprehensive package of geophysical, geological, geochemical, and space environment experiments to complete the complex investigations of this solar-system end member, which begun with Mariner 10. The articles in this book, written by the experts in each area of the MESSENGER mission, describe the mission, spacecraft, scientific objectives, and payload. The book is of interest to all potential users of the data returned by the MESSENGER mission, to those studying the nature of the planet Mercury, and by all those interested in the design and implementation of planetary exploration missions.
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Applicability of neutron activation analysis to geological samples
Energy Technology Data Exchange (ETDEWEB)
Ebihara, Mitsuru [Tokyo Metropolitan Univ., Graduate School of Science, Tokyo (Japan)
2003-03-01
The applicability of neutron activation analysis (NAA) to geological samples in space is discussed by referring to future space mission programs, by which the extraterrestrial samples are to be delivered to the earth for scientific inspections. It is concluded that both destructive and non-destructive NAA are highly effective in analyzing these samples. (author)
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Applicability of neutron activation analysis to geological samples
International Nuclear Information System (INIS)
Ebihara, Mitsuru
2003-01-01
The applicability of neutron activation analysis (NAA) to geological samples in space is discussed by referring to future space mission programs, by which the extraterrestrial samples are to be delivered to the earth for scientific inspections. It is concluded that both destructive and non-destructive NAA are highly effective in analyzing these samples. (author)
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Synergies Between the Kepler, K2 and TESS Missions with the PLATO Mission (Revised)
Jenkins, Jon M.
2017-01-01
Two transit survey missions will have been flown by NASA prior to the launch of ESA's PLATO Mission in 2026, laying the groundwork for exoplanet discovery via the transit method. The Kepler Mission, which launched in 2009, collected data on its 100+ square degree field of view for four years before failure of a reaction wheel ended its primary mission. The results from Kepler include 2300+ confirmed or validated exoplanets, 2200+ planetary candidates, 2100+ eclipsing binaries. Kepler also revolutionized the field of asteroseismology by measuring the pressure mode oscillations of over 15000 solar-like stars spanning the lifecycle of such stars from hydrogen-burning dwarfs to helium-burning red giants. The re-purposed Kepler Mission, dubbed K2, continues to observe fields of view in and near the ecliptic plane for 80 days each, significantly broadening the scope of the astrophysical investigations as well as discovering an additional 156 exoplanets to date. The TESS mission will launch in 2017 to conduct an all-sky survey for small exoplanets orbiting stars 10X closer and 100X brighter than Kepler exoplanet host stars, allowing for far greater follow-up and characterization of their masses as well as their sizes for at least 50 small planets. Future assets such as James Webb Space Telescope, and ground-based assets such as ESOs Very Large Telescope (VLT) array, the Exremely Large Telescope (ELT), and the Thirty Meter Telescope (TMT) will be able to characterize the atmospheric composition and properties of these small planets. TESS will observe each 24 X 96 field of view for 30 days and thereby cover first the southern and then the northern hemisphere over 13 pointings during each year of the primary mission. The pole-most camera will observe the James Webb continuous viewing zone for one year in each hemisphere, permitting much longer period planets to be detected in this region. The PLATO mission will seek to detect habitable Earth-like planets with an instrument
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Wallner, Oswald; Ergenzinger, Klaus; Tuttle, Sean; Vaillon, L.; Johann, Ulrich
2017-11-01
EUCLID, a medium-class mission candidate of ESA's Cosmic Vision 2015-2025 Program, currently in Definition Phase (Phase A/B1), shall map the geometry of the Dark Universe by investigating dark matter distributions, the distance-redshift relationship, and the evolution of cosmic structures. EUCLID consists of a 1.2 m telescope and two scientific instruments for ellipticity and redshift measurements in the visible and nearinfrared wavelength regime. We present a design concept of the EUCLID mission which is fully compliant with the mission requirements. Preliminary concepts of the spacecraft and of the payload including the scientific instruments are discussed.
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Varsi, Giulio
In the last decade, the operation of a spacecraft after launch has emerged as a major component of the total cost of the mission. This trend is sustained by the increasing complexity, flexibility, and data gathering capability of the space assets and by their greater reliability and consequent longevity. The trend can, however, be moderated by the progressive transfer of selected functions from the ground to the spacecraft and by application, on the ground, of new technology. Advances in ground operations derive from the introduction in the mission operations environment of advanced microprocessor-based workstations in the class of a few million instructions per second and from the selective application of artificial intelligence technology. In the last few years a number of these applications have been developed, tested in operational settings and successfully demonstrated to users. Some are now being integrated in mission operations facilities. An analysis of mission operations indicates that the key areas are: concurrent control of multiple missions; automated/interactive production of command sequences of high integrity at low cost; automated monitoring of spacecraft health and automated aides for fault diagnosis; automated allocation of resources; automated processing of science data; and high-fidelity, high-speed spacecraft simulation. Examples of major advances in selected areas are described.
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Body composition and metabolic changes during a 520-day mission simulation to Mars.
Strollo, F; Macchi, C; Eberini, I; Masini, M A; Botta, M; Vassilieva, G; Nichiporuk, I; Monici, M; Santucci, D; Celotti, F; Magni, P; Ruscica, M
2018-03-12
The "Mars-500 project" allowed to evaluate the changes in psychological/physiological adaptation over a prolonged confinement, in order to gather information for future missions. Here, we evaluated the impact of confinement and isolation on body composition, glucose metabolism/insulin resistance and adipokine levels. The "Mars-500 project" consisted of 520 consecutive days of confinement from June 3, 2010 to Nov 4, 2011. The crew was composed of six male subjects (three Russians, two Europeans, and one Chinese) with a median age of 31 years (range 27-38 years). During the 520-day confinement, total body mass and BMI progressively decreased, reaching a significant difference at the end (417 days) of the observation period (- 9.2 and - 5.5%, respectively). Fat mass remained unchanged. A progressive and significant increase of fasting plasma glucose was observed between 249 and 417 days (+ 10/+ 17% vs baseline), with a further increase at the end of confinement (up to + 30%). Median plasma insulin showed a non-significant early increment (60 days; + 86%). Total adiponectin halved (- 47%) 60 days after hatch closure, remaining at this nadir (- 51%) level for a further 60 days. High molecular weight adiponectin remained significantly lower from 60 to 168 days. Based on these data, countermeasures may be envisioned to balance the potentially harmful effects of prolonged confinement, including a better exercise program, with accurate monitoring of (1) the individual activity and (2) the relationship between body composition and metabolic derangement.
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Liquid Effluents Program mission analysis
International Nuclear Information System (INIS)
Lowe, S.S.
1994-01-01
Systems engineering is being used to identify work to cleanup the Hanford Site. The systems engineering process transforms an identified mission need into a set of performance parameters and a preferred system configuration. Mission analysis is the first step in the process. Mission analysis supports early decision-making by clearly defining the program objectives, and evaluating the feasibility and risks associated with achieving those objectives. The results of the mission analysis provide a consistent basis for subsequent systems engineering work. A mission analysis was performed earlier for the overall Hanford Site. This work was continued by a ''capstone'' team which developed a top-level functional analysis. Continuing in a top-down manner, systems engineering is now being applied at the program and project levels. A mission analysis was conducted for the Liquid Effluents Program. The results are described herein. This report identifies the initial conditions and acceptable final conditions, defines the programmatic and physical interfaces and sources of constraints, estimates the resources to carry out the mission, and establishes measures of success. The mission analysis reflects current program planning for the Liquid Effluents Program as described in Liquid Effluents FY 1995 Multi-Year Program Plan
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Lunar Exploration Missions Since 2006
Lawrence, S. J. (Editor); Gaddis, L. R.; Joy, K. H.; Petro, N. E.
2017-01-01
The announcement of the Vision for Space Exploration in 2004 sparked a resurgence in lunar missions worldwide. Since the publication of the first "New Views of the Moon" volume, as of 2017 there have been 11 science-focused missions to the Moon. Each of these missions explored different aspects of the Moon's geology, environment, and resource potential. The results from this flotilla of missions have revolutionized lunar science, and resulted in a profoundly new emerging understanding of the Moon. The New Views of the Moon II initiative itself, which is designed to engage the large and vibrant lunar science community to integrate the results of these missions into new consensus viewpoints, is a direct outcome of this impressive array of missions. The "Lunar Exploration Missions Since 2006" chapter will "set the stage" for the rest of the volume, introducing the planetary community at large to the diverse array of missions that have explored the Moon in the last decade. Content: This chapter will encompass the following missions: Kaguya; ARTEMIS (Acceleration, Reconnection, Turbulence, and Electrodynamics of the Moon’s Interaction with the Sun); Chang’e-1; Chandrayaan-1; Moon Impact Probe; Lunar Reconnaissance Orbiter (LRO); Lunar Crater Observation Sensing Satellite (LCROSS); Chang’e-2; Gravity Recovery and Interior Laboratory (GRAIL); Lunar Atmosphere and Dust Environment Explorer (LADEE); Chang’e-3.
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Integrated Human-Robotic Missions to the Moon and Mars: Mission Operations Design Implications
Mishkin, Andrew; Lee, Young; Korth, David; LeBlanc, Troy
2007-01-01
For most of the history of space exploration, human and robotic programs have been independent, and have responded to distinct requirements. The NASA Vision for Space Exploration calls for the return of humans to the Moon, and the eventual human exploration of Mars; the complexity of this range of missions will require an unprecedented use of automation and robotics in support of human crews. The challenges of human Mars missions, including roundtrip communications time delays of 6 to 40 minutes, interplanetary transit times of many months, and the need to manage lifecycle costs, will require the evolution of a new mission operations paradigm far less dependent on real-time monitoring and response by an Earthbound operations team. Robotic systems and automation will augment human capability, increase human safety by providing means to perform many tasks without requiring immediate human presence, and enable the transfer of traditional mission control tasks from the ground to crews. Developing and validating the new paradigm and its associated infrastructure may place requirements on operations design for nearer-term lunar missions. The authors, representing both the human and robotic mission operations communities, assess human lunar and Mars mission challenges, and consider how human-robot operations may be integrated to enable efficient joint operations, with the eventual emergence of a unified exploration operations culture.
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Tapley, B. D.; Flechtner, F. M.; Watkins, M. M.; Bettadpur, S. V.
2017-12-01
The twin satellites of the Gravity Recovery and Climate Experiment (GRACE) were launched on March 17, 2002 and have operated for nearly 16 years. The mission objectives are to observe the spatial and temporal variations of the Earth's mass through its effects on the gravity field at the GRACE satellite altitude. The mass changes observed are related to both the changes within the solid earth and the change within and between the Erath system components. A significant cause of the time varying mass is water motion and the GRACE mission has provided a continuous decade long measurement sequence which characterizes the seasonal cycle of mass transport between the oceans, land, cryosphere and atmosphere; its inter-annual variability; and the climate driven secular, or long period, mass transport signals. The fifth reanalysis on the mission data set, the RL05 data, were released in mid-2013. With the planned launch of GRACE Follow-On in early 2018, plans are underway for a reanalysis that will be consistent with the GRACE FO processing standards. The mission is entering the final phases of its operation life with mission end expected to occur in early 2018. The current mission operations strategy emphasizes extending the mission lifetime to obtain an overlap with the GRACE FO. This presentation will review the mission status and the projections for mission lifetime, describe the current operations philosophy and its impact on the science data, discuss the issues related to achieving the GRACE and GRACE FO connection and discuss issues related to science data products during this phase of the mission period.
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Hepatic scar in a case of healed candidiasis showing prolonged enhancement on CT
Energy Technology Data Exchange (ETDEWEB)
Itai, Yuji; Yashiro, Naobumi
1987-08-01
A patient with acute myelocytic leukemia recovering from hepatic candidiasis after long-term administration of amphotericin B had large scar in the liver which showed prominent prolonged enhancement on postcontrast CT. Prolonged enhancement can occur in regions other than hepatic masses.
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Internalized stigma in adults with early phase versus prolonged psychosis.
Firmin, Ruth L; Lysaker, Paul H; Luther, Lauren; Yanos, Philip T; Leonhardt, Bethany; Breier, Alan; Vohs, Jenifer L
2018-03-30
Although internalized stigma is associated with negative outcomes among those with prolonged psychosis, surprisingly little work has focused on when in the course of one's illness stigma is internalized and the impact of internalization on symptoms or social functioning over the course of the illness. Therefore, this study investigated whether (1) internalized stigma is greater among those later in the course of psychosis and (2) whether internalized stigma has a stronger negative relationship with social functioning or symptoms among those with prolonged compared to early phase psychosis. Individuals with early phase (n = 40) and prolonged psychosis (n = 71) who were receiving outpatient services at an early-intervention clinic and a VA medical center, respectively, completed self-report measures of internalized stigma and interview-rated measures of symptoms and social functioning. Controlling for education, race and sex differences, internalized stigma was significantly greater among those with prolonged psychosis compared to early phase. Internalized stigma was negatively related to social functioning and positively related to symptoms in both groups. Furthermore, the magnitude of the relationship between cognitive symptoms and internalized stigma was significantly greater among those with early phase. Stereotype endorsement, discrimination experiences and social withdrawal also differentially related to symptoms and social functioning across the 2 samples. Findings suggest that internalized stigma is an important variable to incorporate into models of early psychosis. Furthermore, internalized stigma may be a possible treatment target among those with early phase psychosis. © 2018 John Wiley & Sons Australia, Ltd.
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Overview of Mission Design for NASA Asteroid Redirect Robotic Mission Concept
Strange, Nathan; Landau, Damon; McElrath, Timothy; Lantoine, Gregory; Lam, Try; McGuire, Melissa; Burke, Laura; Martini, Michael; Dankanich, John
2013-01-01
Part of NASA's new asteroid initiative would be a robotic mission to capture a roughly four to ten meter asteroid and redirect its orbit to place it in translunar space. Once in a stable storage orbit at the Moon, astronauts would then visit the asteroid for science investigations, to test in space resource extraction, and to develop experience with human deep space missions. This paper discusses the mission design techniques that would enable the redirection of a 100-1000 metric ton asteroid into lunar orbit with a 40-50 kW Solar Electric Propulsion (SEP) system.
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DEFF Research Database (Denmark)
Hvid, L G; Gejl, Kasper Degn; Bech, R D
2013-01-01
Prolonged muscle activity impairs whole-muscle performance and function. However, little is known about the effects of prolonged muscle activity on the contractile function of human single muscle fibres. The purpose of this study was to investigate the effects of prolonged exercise and subsequent...... recovery on the contractile function of single muscle fibres obtained from elite athletes....
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Correlation of prolonged QT interval and severity of cirrhosis of liver
International Nuclear Information System (INIS)
Tarique, S.; Sarwar, S.
2011-01-01
To determine correlation between prolonged QT interval and severity of disease in patients of cirrhosis of liver. Study Design: Descriptive cross sectional study. Patients and Methods: One hundred and seventeen patients of cirrhosis were included. Baseline haematological and biochemical parameters were determined. Model for end stage liver disease (MELD) score was determined for all patients to document stage of liver disease. Corrected QT interval was determined from electrocardiography of each patient using QT cirrhosis formula. Correlation between QT interval and MELD score was determined using Pearson correlation and Receiver Operating Characteristic (ROC) curve. Results: One hundred and seventeen included patients had mean age of 53.58 (+- 12.11) while male to female ratio was 1.78/1 (75 / 42). Mean MELD score was 17.08 (+- 6.54) in study patients varying between 6 and 37 while mean corrected QT interval was 0.44 seconds (+- 0.06). Pearson correlation revealed no significant relation between severity of liver disease as determined with MELD score and prolonged QT interval (p value 0.18) Area under curve with ROC curve for correlation between prolonged QT interval and severity of liver disease was 0.42. Conclusion: Prolonged QT interval is not an indicator of severity of disease in cirrhosis of liver. (author)
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Coexistence of Ureaplasma and chorioamnionitis is associated with prolonged mechanical ventilation.
Jung, Euiseok; Choi, Chang Won; Kim, Su Yeong; Sung, Tae-Jung; Kim, Haeryoung; Park, Kyoung Un; Kim, Han-Suk; Kim, Beyong Il; Choi, Jung-Hwan
2017-01-01
Both histologic chorioamnionitis (HCAM) and Ureaplasma infection are considered important contributors to perinatal lung injury. We tested the hypothesis that coexistence of maternal HCAM and perinatal Ureaplasma exposure increases the risk of prolonged mechanical ventilation in extremely low-birthweight (ELBW) infants. A retrospective cohort study was carried out of all ELBW infants born between January 2008 and December 2013 at a single academic center. Placental pathology and gastric fluid Ureaplasma data were available for all infants. Culture and polymerase chain reaction were used to detect Ureaplasma in gastric fluid. Prolonged mechanical ventilation was defined as mechanical ventilation that began within 28 days after birth and continued. Of 111 ELBW infants enrolled, 84 survived beyond 36 weeks of postmenstrual age (PMA) and were included in the analysis. Eighteen infants (21.4%) had both HCAM and Ureaplasma exposure. Seven infants (8.3%) required mechanical ventilation beyond 36 weeks of PMA. Coexistence of HCAM and Ureaplasma in gastric fluid was significantly associated with prolonged mechanical ventilation after adjustment for gestational age, sex, mode of delivery, and use of macrolide antibiotics (OR, 8.7; 95%CI: 1.1-67.2). Coexistence of maternal HCAM and perinatal Ureaplasma exposure significantly increases the risk of prolonged mechanical ventilation in ELBW infants. © 2016 Japan Pediatric Society.
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1973-01-01
The mission requirements and conceptual design of manned earth observatory payloads for the 1980 time period are discussed. Projections of 1980 sensor technology and user data requirements were used to formulate typical basic criteria pertaining to experiments, sensor complements, and reference missions. The subjects discussed are: (1) mission selection and prioritization, (2) baseline mission analysis, (3) earth observation data handling and contingency plans, and (4) analysis of low cost mission definition and rationale.
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Lo, C. John; Brophy, John R.; Etters, M. Andy; Ramesham, Rajeshuni; Jones, William R., Jr.; Jansen, Mark J.
2009-01-01
The Dawn Ion Propulsion System is the ninth project in NASA s Discovery Program. The Dawn spacecraft is being developed to enable the scientific investigation of the two heaviest main-belt asteroids, Vesta and Ceres. Dawn is the first mission to orbit two extraterrestrial bodies, and the first to orbit a main-belt asteroid. The mission is enabled by the onboard Ion Propulsion System (IPS) to provide the post-launch delta-V. The three Ion Engines of the IPS are mounted on Thruster Gimbal Assembly (TGA), with only one engine operating at a time for this 10-year mission. The three TGAs weigh 14.6 kg.
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Hepatic scar in a case of healed candidiasis showing prolonged enhancement on CT
International Nuclear Information System (INIS)
Itai, Yuji; Yashiro, Naobumi
1987-01-01
A patient with acute myelocytic leukemia recovering from hepatic candidiasis after long-term administration of amphotericin B had large scar in the liver which showed prominent prolonged enhancement on postcontrast CT. Prolonged enhancement can occur in regions other than hepatic masses. (author)
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Prolonged QTc interval and risk of sudden cardiac death in a population of older adults
DEFF Research Database (Denmark)
Straus, Sabine M J M; Kors, Jan A; De Bruin, Marie L
2006-01-01
OBJECTIVES: This study sought to investigate whether prolongation of the heart rate-corrected QT (QTc) interval is a risk factor for sudden cardiac death in the general population. BACKGROUND: In developed countries, sudden cardiac death is a major cause of cardiovascular mortality. Prolongation...... of the QTc interval has been associated with ventricular arrhythmias, but in most population-based studies no consistent association was found between QTc prolongation and total or cardiovascular mortality. Only very few of these studies specifically addressed sudden cardiac death. METHODS: This study......). The association between a prolonged QTc interval and sudden cardiac death was estimated using Cox proportional hazards analysis. RESULTS: During an average follow-up period of 6.7 years (standard deviation, 2.3 years) 125 patients died of sudden cardiac death. An abnormally prolonged QTc interval (>450 ms in men...
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Prolonged storage of packed red blood cells for blood transfusion.
Martí-Carvajal, Arturo J; Simancas-Racines, Daniel; Peña-González, Barbra S
2015-07-14
A blood transfusion is an acute intervention, used to address life- and health-threatening conditions on a short-term basis. Packed red blood cells are most often used for blood transfusion. Sometimes blood is transfused after prolonged storage but there is continuing debate as to whether transfusion of 'older' blood is as beneficial as transfusion of 'fresher' blood. To assess the clinical benefits and harms of prolonged storage of packed red blood cells, in comparison with fresh, on recipients of blood transfusion. We ran the search on 1st May 2014. We searched the Cochrane Injuries Group Specialized Register, Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), MEDLINE (OvidSP), Embase (OvidSP), CINAHL (EBSCO Host) and two other databases. We also searched clinical trials registers and screened reference lists of the retrieved publications and reviews. We updated this search in June 2015 but these results have not yet been incorporated. Randomised clinical trials including participants assessed as requiring red blood cell transfusion were eligible for inclusion. Prolonged storage was defined as red blood cells stored for ≥ 21 days in a blood bank. We did not apply limits regarding the duration of follow-up, or country where the study took place. We excluded trials where patients received a combination of short- and long-stored blood products, and also trials without a clear definition of prolonged storage. We independently performed study selection, risk of bias assessment and data extraction by at least two review authors. The major outcomes were death from any cause, transfusion-related acute lung injury, and adverse events. We estimated relative risk for dichotomous outcomes. We measured statistical heterogeneity using I(2). We used a random-effects model to synthesise the findings. We identified three randomised clinical trials, involving a total of 120 participants, comparing packed red blood cells with ≥ 21 days storage
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Directory of Open Access Journals (Sweden)
Feng-Cheng Tang
Full Text Available Prolonged fatigue is common among employees, but the relationship between prolonged fatigue and job-related psychosocial factors is seldom studied. This study aimed (1 to assess the individual relations of physical condition, psychological condition, and job-related psychosocial factors to prolonged fatigue among employees, and (2 to clarify the associations between job-related psychosocial factors and prolonged fatigue using hierarchical regression when demographic characteristics, physical condition, and psychological condition were controlled.A cross-sectional study was employed. A questionnaire was used to obtain information pertaining to demographic characteristics, physical condition (perceived physical health and exercise routine, psychological condition (perceived mental health and psychological distress, job-related psychosocial factors (job demand, job control, and workplace social support, and prolonged fatigue.A total of 3,109 employees were recruited. Using multiple regression with controlled demographic characteristics, psychological condition explained 52.0% of the variance in prolonged fatigue. Physical condition and job-related psychosocial factors had an adjusted R2 of 0.370 and 0.251, respectively. Hierarchical multiple regression revealed that, among job-related psychosocial factors, job demand and job control showed significant associations with fatigue.Our findings highlight the role of job demand and job control, in addition to the role of perceived physical health, perceived mental health, and psychological distress, in workers' prolonged fatigue. However, more research is required to verify the causation among all the variables.
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Safety and efficacy of prolonged epidural analgesia after oncologic colorectal surgery
Directory of Open Access Journals (Sweden)
R. V. Garyaev
2012-01-01
Full Text Available This study demonstrates effective thoracic epidural analgesia by ropivacain 0.2 %, phentanyl 2 mkg/ml, adrenaline 2 mkg/ml in single-use infusion pumps in 124 patients, who underwent surgery for colorectal cancer. Safe, effective and controllable analgesia was observed during surgery and postoperative period. Prolonged analgesia facilitates early rehabilitation and improves gastrointestinal peristaltic activity. Prolonged epidural analgesia is the recommended method of analgesia in this group of patients.
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Ballooning for Biologists: Mission Essentials for Flying Experiments on Large NASA Balloons
Smith, David J.; Sowa, Marianne
2017-01-01
Despite centuries of scientific balloon flights, only a handful of experiments have produced biologically-relevant results. Yet unlike orbital spaceflight, it is much faster and cheaper to conduct biology research with balloons, sending specimens to the near space environment of Earths stratosphere. Samples can be loaded the morning of a launch and sometimes returned to the laboratory within one day after flying. The National Aeronautics and Space Administration (NASA) flies large, unmanned scientific balloons from all over the globe, with missions ranging from hours to weeks in duration. A payload in the middle portion of the stratosphere (approx. 35 km above sea level) will be exposed to an environment similar to the surface of Mars: temperatures generally around -36 C, atmospheric pressure at a thin 1 kPa, relative humidity levels <1%, and a harsh illumination of ultraviolet (UV) and cosmic radiation levels (about 100 W/sq m and 0.1 mGy/d, respectively) that can be obtained nowhere else on the surface of the Earth, including environmental chambers and particle accelerator facilities attempting to simulate space radiation effects. Considering the operational advantages of ballooning and the fidelity of space-like stressors in the stratosphere, researchers in aerobiology, astrobiology, and space biology can benefit from balloon flight experiments as an intermediary step on the extraterrestrial continuum (ground, low Earth orbit, and deep space studies). Our presentation targets biologists with no background or experience in scientific ballooning. We will provide an overview of large balloon operations, biology topics that can be uniquely addressed in the stratosphere, and a roadmap for developing payloads to fly with NASA.
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Translating QT interval prolongation from conscious dogs to humans.
Dubois, Vincent F S; Smania, Giovanni; Yu, Huixin; Graf, Ramona; Chain, Anne S Y; Danhof, Meindert; Della Pasqua, Oscar
2017-02-01
In spite of screening procedures in early drug development, uncertainty remains about the propensity of new chemical entities (NCEs) to prolong the QT/QTc interval. The evaluation of proarrhythmic activity using a comprehensive in vitro proarrhythmia assay does not fully account for pharmacokinetic-pharmacodynamic (PKPD) differences in vivo. In the present study, we evaluated the correlation between drug-specific parameters describing QT interval prolongation in dogs and in humans. Using estimates of the drug-specific parameter, data on the slopes of the PKPD relationships of nine compounds with varying QT-prolonging effects (cisapride, sotalol, moxifloxacin, carabersat, GSK945237, SB237376 and GSK618334, and two anonymized NCEs) were analysed. Mean slope estimates varied between -0.98 ms μM -1 and 6.1 ms μM -1 in dogs and -10 ms μM -1 and 90 ms μM -1 in humans, indicating a wide range of effects on the QT interval. Linear regression techniques were then applied to characterize the correlation between the parameter estimates across species. For compounds without a mixed ion channel block, a correlation was observed between the drug-specific parameter in dogs and humans (y = -1.709 + 11.6x; R 2 = 0.989). These results show that per unit concentration, the drug effect on the QT interval in humans is 11.6-fold larger than in dogs. Together with information about the expected therapeutic exposure, the evidence of a correlation between the compound-specific parameter in dogs and in humans represents an opportunity for translating preclinical safety data before progression into the clinic. Whereas further investigation is required to establish the generalizability of our findings, this approach can be used with clinical trial simulations to predict the probability of QT prolongation in humans. © 2016 The British Pharmacological Society.
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Community College Mission: A '60s Mission Looking at a Y2K World.
Levin, Bernard H.
Although the world has changed considerably in the past three decades, community colleges and their guiding missions have largely not adapted to changing conditions. College mission statements tend to be unfocused documents that provide overly broad goals. In the business world, the mission statements of effective companies are brief, crisp, and…
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Hammond, Ernest C., Jr.
1987-01-01
The results of these studies have implications for the utilization of the IIaO spectroscopic film on the future shuttle and space lab missions. These responses to standard photonic energy sources will have immediate application for the uneven responses of the film photographing a star field in a terrestrial or extraterrestrial environment with associated digital imaging equipment.
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Stansbery, EIleen K.; Latner, Alexis Glynn
2000-01-01
Extraterrestrial material eternally rains down on Earth. Meteorites flare in the night sky. Cosmic rays plow into Earth's atmosphere, creating invisible bursts of secondary particles. These processes began when the Earth formed in the primordial solar system and have continued ever since, indifferent to the exceedingly recent presence of human intelligence. For us to seek out stuff of other worlds, in contrast, takes a great deal of determined ingenuity. First we have to send a spacecraft somewhere else in the solar system. Indigenous material has to be collected and then brought back to Earth without exposure to conditions that might significantly alter it. The material must undergo meaningful scientific analysis. Most important, part of the material is preserved intact for future investigations. Beginning with bringing back Moon rocks, and now moving onward in the form of new missions to capture the hot thin solar wind and cold thin atmosphere of comets, extraterrestrial sample return takes place on the cutting edge of scientific technology. Sample return is also the fulcrum of an energetic debate about how to do planetary science missions. Scientists and engineers are debating whether to rely on remote sensing and in situ analysis, or to plan missions to undertake sample return. The latter is definitely more expensive on a per mission basis, and is usually technologically more challenging. But for an initially high investment of money and technology, bringing the stuff of other worlds back to Earth yields an incomparable return in scientific results.
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Prolonged Exposure Therapy For Post Traumatic Stress Disorder
Directory of Open Access Journals (Sweden)
Levent SÜTÇİGİL
2012-07-01
Full Text Available Post-traumatic Stress Disorder (PTSD is a psychiatric illness that usually develops after an event that threatens one’s life and body integrity and it affects quality of life and impairs social functioning significantly. Many studies have shown therapeutic effect of cognitive behavioral therapies on posttraumatic stress disorder, so that these therapies take part in the first step of treatment guides. Exposure is a practice that is generally used to reduce pathological fear and related emotions common in posttraumatic stress disorder (PTSD and other anxiety disorders. During exposure, patients intentionally confront with feared objects, situations, thoughts and similar stimuli in order to reduce anxiety level. Exposure can be divided into two main techniques as in vivo exposure and imaginal exposure. Prolonged exposure therapy is a specialized treatment program configured for the treatment of posttraumatic stress disorder and it is based on emotional processing theory. Program is comprised of four main components: (a Psycho-education about trauma and posttraumatic disorders, (b Training for breathing exercises, (c repeated facing with objects, persons, situations and thoughts which causes re-experience about trauma, (d Patient are instructed for telling repeatedly and loudly about traumatic experiences . Prolonged exposure usually involves 9 to 12 sessions, each lasting about 60-90 minutes, administered once or twice a week. Prolonged exposure therapy was started to be implemented since the 1980s, during this period the effectiveness of the therapy has been shown in various empirical studies.
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Prolonged jaundice in newborns is associated with low antioxidant capacity in breast milk.
Uras, Nurdan; Tonbul, Alpaslan; Karadag, Ahmet; Dogan, Derya G; Erel, Ozcan; Tatli, Mustafa M
2010-10-01
In breastfeeding newborns who are otherwise healthy, the mechanism of prolonged jaundice remains unclear. The aim of this study was to investigate relations between prolonged jaundice and oxidative parameters in breast milk. Full-term, otherwise healthy newborns with jaundice lasting more than 2 weeks were enrolled prospectively in the study. As a control group, newborns in the same age group but without prolonged jaundice were selected. All newborns in the study were exclusively breastfed. In the newborns with prolonged jaundice, investigations of the etiology of the jaundice included complete blood count, peripheral blood smear, blood typing, direct Coombs test, measurement of serum levels of total and direct bilirubin, tests for liver and thyroid function (TSH, free T4, total T4), urine culture and measurement of urine reducing substances, and determination of glucose 6 phosphate dehydrogenase enzyme levels. Breast milk was collected from the mothers of the newborns in both groups. The antioxidant status of the breast milk was assessed via determination of total antioxidant capacity (TAC). Oxidative stress was also assessed in breast milk by measurement of total oxidation status (TOS) and calculation of the oxidative stress index (OSI). The prolonged jaundice group differed significantly from the control group in terms of mean TAC and OSI (p antioxidant capacity was found to be decreased.
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QTc-prolonging drugs and hospitalizations for cardiac arrhythmias
DEFF Research Database (Denmark)
De Bruin, Marie L; Hoes, Arno W; Leufkens, Hubert G M
2003-01-01
Cardiac arrhythmia as an adverse effect of noncardiac drugs has been an issue of growing importance during the past few years. In this population-based study, we evaluated the risk for serious cardiac arrhythmias during the use of several noncardiac QTc-prolonging drugs in day-to-day practice......, and subsequently focused on several specific groups of patients who could be extremely vulnerable for drug-induced arrhythmias. We performed a case-control study in which patients (cases), hospitalized for nonatrial cardiac arrhythmias from 1987 to 1998, were compared with their matched controls regarding current...... use of QTc-prolonging drugs. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariate conditional logistic regression, adjusting for potential confounding factors. Data were obtained from the PHARMO record linkage system. We identified 501 cases, 39 of whom used QTc...
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Mission operations update for the restructured Earth Observing System (EOS) mission
Kelly, Angelita Castro; Chang, Edward S.
1993-01-01
The National Aeronautics and Space Administration's (NASA) Earth Observing System (EOS) will provide a comprehensive long term set of observations of the Earth to the Earth science research community. The data will aid in determining global changes caused both naturally and through human interaction. Understanding man's impact on the global environment will allow sound policy decisions to be made to protect our future. EOS is a major component of the Mission to Planet Earth program, which is NASA's contribution to the U.S. Global Change Research Program. EOS consists of numerous instruments on multiple spacecraft and a distributed ground system. The EOS Data and Information System (EOSDIS) is the major ground system developed to support EOS. The EOSDIS will provide EOS spacecraft command and control, data processing, product generation, and data archival and distribution services for EOS spacecraft. Data from EOS instruments on other Earth science missions (e.g., Tropical Rainfall Measuring Mission (TRMM)) will also be processed, distributed, and archived in EOSDIS. The U.S. and various International Partners (IP) (e.g., the European Space Agency (ESA), the Ministry of International Trade and Industry (MITI) of Japan, and the Canadian Space Agency (CSA)) participate in and contribute to the international EOS program. The EOSDIS will also archive processed data from other designated NASA Earth science missions (e.g., UARS) that are under the broad umbrella of Mission to Planet Earth.
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Levofloxacin?Induced QTc Prolongation Depends on the Time of Drug Administration
Kervezee, L; Gotta, V; Stevens, J; Birkhoff, W; Kamerling, IMC; Danhof, M; Meijer, JH; Burggraaf, J
2016-01-01
Understanding the factors influencing a drug's potential to prolong the QTc interval on an electrocardiogram is essential for the correct evaluation of its safety profile. To explore the effect of dosing time on drug-induced QTc prolongation, a randomized, crossover, clinical trial was conducted in which 12 healthy male subjects received levofloxacin at 02:00, 06:00, 10:00, 14:00, 18:00, and 22:00. Using a pharmacokinetic-pharmacodynamic (PK-PD) modeling approach to account for variations in ...
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Intelligent Mission Controller Node
National Research Council Canada - National Science Library
Perme, David
2002-01-01
The goal of the Intelligent Mission Controller Node (IMCN) project was to improve the process of translating mission taskings between real-world Command, Control, Communications, Computers, and Intelligence (C41...
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Life support approaches for Mars missions
Drysdale, A. E.; Ewert, M. K.; Hanford, A. J.
Life support approaches for Mars missions are evaluated using an equivalent system mass (ESM) approach, in which all significant costs are converted into mass units. The best approach, as defined by the lowest mission ESM, depends on several mission parameters, notably duration, environment and consequent infrastructure costs, and crew size, as well as the characteristics of the technologies which are available. Generally, for the missions under consideration, physicochemical regeneration is most cost effective. However, bioregeneration is likely to be of use for producing salad crops for any mission, for producing staple crops for medium duration missions, and for most food, air and water regeneration for long missions (durations of a decade). Potential applications of in situ resource utilization need to be considered further.
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The hemodynamic effects of prolonged respiratory alkalosis in anesthetized newborn piglets.
Jundi, K; Barrington, K J; Henderson, C; Allen, R G; Finer, N N
2000-04-01
To test the hypothesis that prolonged alkalosis decreases cardiac output and, furthermore, exacerbates hypoxic pulmonary vasoconstriction, as respiratory alkalosis is frequently induced as a therapy for persistent pulmonary hypertension of the newborn despite a lack of controlled evidence of improved outcomes. Potential adverse effects of prolonged alkalosis have been demonstrated. Two groups (control, n = 6, and hypocapnic alkalosis, n = 6) of 1-3 day old fentanyl-anesthetized, vecuronium-paralyzed piglets were instrumented to measure cardiac index (CI) and mean systemic (MAP) and pulmonary (PAP) arterial pressures. Baseline values were recorded. Alveolar hypoxia was then induced to achieve an arterial oxygen saturation of between 50 and 60% for 15 min. Respiratory alkalosis was then induced, by increasing ventilation to achieve a pH between 7.55-7.60, and was continued for 240 min. Inspired carbon dioxide was used with hyperventilation in the control group to maintain pressure of arterial carbon dioxide (PaCO2) at 35-45 mmHg and pH of 7.35-7.45. Hypoxia was induced again at 15 and 240 min. Pulmonary and systemic vascular resistances (PVR and SVR) were calculated. Prolonged alkalosis led to a significant and progressive fall in mean MAP from 61 (SD 7) mmHg at the start of the study falling to 50 (SD 6.9, p = 0.043), with no effect on CI. Calculated SVR decreased (0.45 SD 0.03 vs 0.36 SD 0.05). There were no statistically significant changes in any of the variables in the control group. Neither acute nor prolonged respiratory alkalosis had a significant effect on hypoxic pulmonary vasoconstriction. Prolonged hyperventilation leads to systemic hypotension, however it does not exacerbate hypoxic pulmonary vasoconstriction.
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Post-traumatic stress disorder after weaning from prolonged mechanical ventilation.
Jubran, Amal; Lawm, Gerald; Duffner, Lisa A; Collins, Eileen G; Lanuza, Dorothy M; Hoffman, Leslie A; Tobin, Martin J
2010-12-01
Weaning from prolonged mechanical ventilation may be associated with mental discomfort. It is not known whether such discomfort is linked with the development of post-traumatic stress disorder (PTSD). Accordingly, we investigated whether PTSD occurs in patients after weaning from prolonged ventilation. We also determined whether administering a questionnaire would identify patients at risk for developing PTSD. A prospective longitudinal study of patients transferred to a long-term acute-care hospital for weaning from prolonged ventilation was undertaken: 72 patients were studied 1 week after weaning, and 41 patients were studied again 3 months later. An experienced psychologist conducted a structured clinical interview 3 months after weaning to establish a diagnosis of PTSD. To assess for the presence of PTSD-related symptoms, the post-traumatic stress syndrome (PTSS-10) questionnaire was administered 1 week after weaning and 3 months later. The psychologist diagnosed PTSD in 12% of patients 3 months after ventilator weaning. Patients who developed PTSD were more likely to have a previous history of psychiatric disorders (P 20 one week after weaning reliably identified patients who were diagnosed with PTSD 3 months later: sensitivity 1.0; specificity 0.76; area under the receiver-operating characteristic curve 0.91. PTSD was diagnosed in 12% of patients who were weaned from prolonged ventilation. A PTSS-10 score >20 one week after weaning identified patients diagnosed with PTSD 3 months later. This finding suggests that a simple questionnaire administered before hospital discharge can identify patients at risk for developing PTSD.
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Sidestep and crossover lower limb kinematics during a prolonged sport-like agility test.
Potter, Danielle; Reidinger, Kellie; Szymialowicz, Rebecca; Martin, Thomas; Dione, Donald; Feinn, Richard; Wallace, David; Garbalosa, Juan C
2014-10-01
Non-contact anterior cruciate ligament (ACL) injuries in athletes occur more often towards the end of athletic competitions. However, the exact mechanisms of how prolonged activity increases the risk for ACL injuries are not clear. To determine the effect of prolonged activity on the hip and knee kinematics observed during self-selected cutting maneuvers performed in a timed agility test. Nineteen female Division I collegiate soccer players completed a self-selected cutting agility test until they were unable to meet a set performance time (one standard deviation of the average baseline trial). Using the 3D dimensional coordinate data the cut type was identified by the principle investigators. The 3D hip and knee angles at 32ms post heel strike were analyzed using a two-factor, linear mixed model to assess the effect of prolonged activity and cut type on the recorded mean hip and knee angles. Athletes performed either sidestep or crossover cuts. An effect of cut type and prolonged activity was seen at the hip and knee. During the prolonged activity trials, the knee was relatively more adducted and both the hip and knee were less flexed than during the baseline trials regardless of cut type. Regardless of activity status, during sidestep cuts, the hip was more internally rotated and abducted, and less flexed than during crossover cuts while the knee was more abducted and less flexed during the sidestep than crossover cuts. During a sport-like agility test, prolonged activity appears to predispose the athlete to position their knee in a more extended and abducted posture and their hip in a more extended posture. This position has been suggested to place stress on the ACL and potentially increase the risk for injury. Clinicians may want to consider the effects of prolonged activity on biomechanical risk factors for sustaining ACL injuries in the design of intervention strategies to prevent ACL injuries. Level 4.
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A Multicenter Evaluation of Prolonged Empiric Antibiotic Therapy in Adult ICUs in the United States.
Thomas, Zachariah; Bandali, Farooq; Sankaranarayanan, Jayashri; Reardon, Tom; Olsen, Keith M
2015-12-01
The purpose of this study is to determine the rate of prolonged empiric antibiotic therapy in adult ICUs in the United States. Our secondary objective is to examine the relationship between the prolonged empiric antibiotic therapy rate and certain ICU characteristics. Multicenter, prospective, observational, 72-hour snapshot study. Sixty-seven ICUs from 32 hospitals in the United States. Nine hundred ninety-eight patients admitted to the ICU between midnight on June 20, 2011, and June 21, 2011, were included in the study. None. Antibiotic orders were categorized as prophylactic, definitive, empiric, or prolonged empiric antibiotic therapy. Prolonged empiric antibiotic therapy was defined as empiric antibiotics that continued for at least 72 hours in the absence of adjudicated infection. Standard definitions from the Centers for Disease Control and Prevention were used to determine infection. Prolonged empiric antibiotic therapy rate was determined as the ratio of the total number of empiric antibiotics continued for at least 72 hours divided by the total number of empiric antibiotics. Univariate analysis of factors associated with the ICU prolonged empiric antibiotic therapy rate was conducted using Student t test. A total of 660 unique antibiotics were prescribed as empiric therapy to 364 patients. Of the empiric antibiotics, 333 of 660 (50%) were continued for at least 72 hours in instances where Centers for Disease Control and Prevention infection criteria were not met. Suspected pneumonia accounted for approximately 60% of empiric antibiotic use. The most frequently prescribed empiric antibiotics were vancomycin and piperacillin/tazobactam. ICUs that utilized invasive techniques for the diagnosis of ventilator-associated pneumonia had lower rates of prolonged empiric antibiotic therapy than those that did not, 45.1% versus 59.5% (p = 0.03). No other institutional factor was significantly associated with prolonged empiric antibiotic therapy rate. Half of all
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Humenik, Mark
2014-01-01
Some dentists prefer solo charity work, but there is much to be said for collaboration within the profession in reaching out to those who are dentally underserved. Mission of Mercy (MOM) programs are regularly organized across the country for this purpose. This article describes the structure, reach, and personal satisfaction to be gained from such missions.
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Tang, Feng-Cheng; Li, Ren-Hau; Huang, Shu-Ling
2016-01-01
Background and Objectives Prolonged fatigue is common among employees, but the relationship between prolonged fatigue and job-related psychosocial factors is seldom studied. This study aimed (1) to assess the individual relations of physical condition, psychological condition, and job-related psychosocial factors to prolonged fatigue among employees, and (2) to clarify the associations between job-related psychosocial factors and prolonged fatigue using hierarchical regression when demographic characteristics, physical condition, and psychological condition were controlled. Methods A cross-sectional study was employed. A questionnaire was used to obtain information pertaining to demographic characteristics, physical condition (perceived physical health and exercise routine), psychological condition (perceived mental health and psychological distress), job-related psychosocial factors (job demand, job control, and workplace social support), and prolonged fatigue. Results A total of 3,109 employees were recruited. Using multiple regression with controlled demographic characteristics, psychological condition explained 52.0% of the variance in prolonged fatigue. Physical condition and job-related psychosocial factors had an adjusted R2 of 0.370 and 0.251, respectively. Hierarchical multiple regression revealed that, among job-related psychosocial factors, job demand and job control showed significant associations with fatigue. Conclusion Our findings highlight the role of job demand and job control, in addition to the role of perceived physical health, perceived mental health, and psychological distress, in workers’ prolonged fatigue. However, more research is required to verify the causation among all the variables. PMID:26930064
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Etiologies of Prolonged Unconjugated Hyperbilirubinemia in Neonates Admitted to Neonatal Wards
Directory of Open Access Journals (Sweden)
Mohammad Kazem Sabzehei
2015-12-01
Full Text Available Background: Jaundice is a common condition among neonates. Prolonged unconjugated hyperbilirubinemia occurs when jaundice persists beyond two weeks in term neonates and three weeks in preterm neonates. This study aimed to determine the etiologies of prolonged unconjugated hyperbilirubinemia in infants admitted to the neonatal ward of Besat Hospital in Hamadan, Iran. Methods: This study was conducted on all infants diagnosed with prolonged unconjugated hyperbilirubinemia during 2007-2012 in the neonatal ward of Besat Hospital in Hamadan, Iran. Demographic characteristics of infants, physical examination and laboratory findings were collected and analyzed to determine the etiologies of neonatal hyperbilirubinemia. Results: In total, 100 infants diagnosed with neonatal hyperbilirubinemia were enrolled in this study, including 49 male and 51 female neonates with mean age of 20±1 days and mean bilirubin level of 17.5±4.0 mg/dL. Main causes of hyperbilirubinemia were urinary tract infection, ABO incompatibility, hypothyroidism and glucose-6-phosphate dehydrogenase deficiency in 14%, 5%, 6% and 5% of neonates, respectively. Moreover, unknown etiologies, such as breastfeeding, were detected in 70% of the studied infants. Conclusion: According to the results of this study, determining the main causes of prolonged unconjugated hyperbilirubinemia in neonates is of paramount importance. In the majority of cases, neonatal hyperbilirubinemia is associated with physiological factors, such as breastfeeding.
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Marked QTc prolongation and Torsades de Pointes in patients with chronic inflammatory arthritis
Directory of Open Access Journals (Sweden)
Pietro Enea Lazzerini
2016-09-01
Full Text Available Mounting evidence indicates that in chronic inflammatory arthritis (CIA, QTc prolongation is frequent and correlates with systemic inflammatory activation. Notably, basic studies demonstrated that inflammatory cytokines induce profound changes in potassium and calcium channels resulting in a prolonging effect on cardiomyocyte action potential duration (APD, thus on the QT interval on the electrocardiogram. Moreover, it has been demonstrated that in RA patients the risk of SCD is significantly increased when compared to non-RA subjects. Conversely, to date no data are available about Torsades de Pointes (TdP prevalence in CIA, and the few case reported considered CIA only an incidental concomitant disease, not contributing factor to TdP development.We report three patients with active CIA developing marked QTc prolongation, in two cases complicated with TdP degenerating to cardiac arrest. In these patients, a blood sample was obtained within 24h from TdP/marked QTc prolongation occurrence and levels of IL-6, TNF-alpha and IL-1 were evaluated. In all three cases, IL-6 was markedly elevated, ~10 to 100 times more than reference values. Moreover, one patient also showed high circulating levels of TNF-alpha and IL-1. In conclusion, active CIA may represent a currently overlooked QT-prolonging risk factor, potentially contributing in the presence of other classical risk factors to TdP occurrence. In particular, a relevant role may be played by elevated circulating IL-6 levels via direct electrophysiological effects on the heart. This observation should be carefully kept in mind, particularly when recognizable risk factors are already present and/or the addition of QT-prolonging drugs is required.
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A Saturn Ring Observer Mission Using Multi-Mission Radioisotope Power Systems
International Nuclear Information System (INIS)
Abelson, Robert D.; Spilker, Thomas R.; Shirley, James H.
2006-01-01
Saturn remains one of the most fascinating planets within the solar system. To better understand the complex ring structure of this planet, a conceptual Saturn Ring Observer (SRO) mission is presented that would spend one year in close proximity to Saturn's A and B rings, and perform detailed observations and measurements of the ring particles and electric and magnetic fields. The primary objective of the mission would be to understand ring dynamics, including the microphysics of individual particles and small scale (meters to a few kilometers) phenomena such as particle agglomeration behavior. This would be accomplished by multispectral imaging of the rings at multiple key locations within the A and B rings, and by ring-particle imaging at an unprecedented resolution of 0.5 cm/pixel. The SRO spacecraft would use a Venus-Earth-Earth-Jupiter Gravity Assist (VEEJGA) and be aerocaptured into Saturn orbit using an advanced aeroshell design to minimize propellant mass. Once in orbit, the SRO would stand off from the ring plane 1 to 1.4 km using chemical thrusters to provide short propulsive maneuvers four times per revolution, effectively causing the SRO vehicle to 'hop' above the ring plane. The conceptual SRO spacecraft would be enabled by the use of a new generation of multi-mission Radioisotope Power Systems (RPSs) currently being developed by NASA and DOE. These RPSs include the Multi-Mission Radioisotope Thermoelectric Generator (MMRTG) and Stirling Radioisotope Generator (SRG). The RPSs would generate all necessary electrical power (≥330 We at beginning of life) during the 10-year cruise and 1-year science mission (∼11 years total). The RPS heat would be used to maintain the vehicle's operating and survival temperatures, minimizing the need for electrical heaters. Such a mission could potentially launch in the 2015-2020 timeframe, with operations at Saturn commencing in approximately 2030
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Integrated payload and mission planning, phase 3. Volume 3: Ground real-time mission operations
White, W. J.
1977-01-01
The payloads tentatively planned to fly on the first two Spacelab missions were analyzed to examine the cost relationships of providing mission operations support from onboard vs the ground-based Payload Operations Control Center (POCC). The quantitative results indicate that use of a POCC, with data processing capability, to support real-time mission operations is the most cost effective case.
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A decision model for planetary missions
Hazelrigg, G. A., Jr.; Brigadier, W. L.
1976-01-01
Many techniques developed for the solution of problems in economics and operations research are directly applicable to problems involving engineering trade-offs. This paper investigates the use of utility theory for decision making in planetary exploration space missions. A decision model is derived that accounts for the objectives of the mission - science - the cost of flying the mission and the risk of mission failure. A simulation methodology for obtaining the probability distribution of science value and costs as a function spacecraft and mission design is presented and an example application of the decision methodology is given for various potential alternatives in a comet Encke mission.
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The Importance of Prolonged Provocation in Drug Allergy
DEFF Research Database (Denmark)
Fransson, Sara; Mosbech, Holger; Kappel, Mogens
2017-01-01
BACKGROUND: Drug provocation is the "Gold Standard" in drug allergy investigation. Recent studies suggest that a negative drug provocation on first dose should be followed by a prolonged provocation over several days. OBJECTIVE: To evaluate drug allergy investigations on the basis of drug...
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Ranjan, Amalendu P; Mukerjee, Anindita; Helson, Lawrence; Vishwanatha, Jamboor K
2013-12-14
Cardiac toxicity is the foremost reason for drug discontinuation from development to clinical evaluation and post market surveillance [Fung 35:293-317, 2001; Piccini 158:317-326 2009]. The Food and Drug Administration (FDA) has rejected many potential pharmaceutical agents due to QT prolongation effects. Since drug development and FDA approval takes an enormous amount of time, money and effort with high failure rates, there is an increased focus on rescuing drugs that cause QT prolongation. If these otherwise safe and potent drugs were formulated in a unique way so as to mitigate the QT prolongation associated with them, these potent drugs may get FDA approval for clinical use. Rescuing these compounds not only benefit the patients who need them but also require much less time and money thus leading to faster clinical translation. In this study, we chose curcumin as our drug of choice since it has been shown to posses anti-tumor properties against various cancers with limited toxicity. The major limitations with this pharmacologically active drug are (a) its ability to prolong QT by inhibiting the hERG channel and (b) its low bioavailability. In our previous studies, we found that lipids have protective actions against hERG channel inhibition and therefore QT prolongation. Results of the manual patch clamp assay of HEK 293 cells clearly illustrated that our hybrid nanocurcumin formulation prevented the curcumin induced inhibition of hERG K+ channel at concentrations higher than the therapeutic concentrations of curcumin. Comparing the percent inhibition, the hybrid nanocurcumin limited inhibition to 24.8% at a high curcumin equivalent concentration of 18 μM. Liposomal curcumin could only decrease this inhibition upto 30% only at lower curcumin concentration of 6 μM but not at 18 μM concentration. Here we show a curcumin encapsulated lipopolymeric hybrid nanoparticle formulation which could protect against QT prolongation and also render increased
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Prolonged minor allograft survival in intravenously primed mice--a test of the veto hypothesis
International Nuclear Information System (INIS)
Johnson, L.L.
1987-01-01
Experiments were performed to test the hypothesis that veto cells are responsible for the prolonged survival of minor allografts of skin that is observed in recipients primed intravenously with spleen cells from mice syngeneic with the skin donors. This prolonged survival was observed for each of several minor histocompatibility (H) antigens and is antigen-specific. Gamma radiation (3300 rads) abolished the ability of male spleen cells infused i.v. to delay the rejection of male skin grafts (H-Y antigen) on female recipients. However, depletion of Thy-1+ cells from the i.v. infusion failed to abolish the ability to prolong male skin graft survival. Furthermore, the prolonged survival accorded to B6 (H-2b) male skin grafts on CB6F1 (H-2b/H-2d) female recipients given i.v. infusions of B6 male spleen cells extended to BALB/c (H-2d) male skin grafts as well, indicating a lack of MHC restriction. Thus, prolongation of minor allograft survival by i.v. infusion of minor H antigen-bearing spleen cells appears not to depend on veto T cells that others have found to be responsible for the suppression of CTL generation
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Prolonged radioprotective activity of WR-2721 linked to dextran
International Nuclear Information System (INIS)
Moenig, H.; Konermann, G.; Oehlert, W.
1990-01-01
The radioprotective agent WR-2721 was linked to dextran and poly(glutamic acid) respectively, to obtain a prolonged radioprotective ability. Male mice were administered these water soluble polymer conjugates one to 72 hours prior to a whole body irradiation with X-rays. A prolongation of radioprotective efficiency was achieved with two dextran-(WR-2721)-conjugates. For a period of 24 hours between administration, and irradiation dose reduction factors of 1.14±0.04 and 1.10±0.03 respectively were found. After 72 hours, no protective effect was observed. Histopathological investigations of the liver for formation of tumors 200 to 600 days after irradiation seems to indicate that a protective effect is not produced by the dextran-(WR-2721)-conjugats. (orig.) [de
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Critical Robotic Lunar Missions
Plescia, J. B.
2018-04-01
Perhaps the most critical missions to understanding lunar history are in situ dating and network missions. These would constrain the volcanic and thermal history and interior structure. These data would better constrain lunar evolution models.
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Journaux, B.; Brown, J. M.; Bollengier, O.; Abramson, E.
2017-12-01
As in Earth arctic and Antarctic regions, suspected extraterrestrial deep oceans in icy worlds (i.e. icy moons and water-rich exoplanets) chemistry and thermodynamic state will strongly depend on their equilibrium with H2O ice and present solutes. Na-Mg-Cl-SO4 salt species are currently the main suspected ionic solutes to be present in deep oceans based on remote sensing, magnetic field measurements, cryovolcanism ice grains chemical analysis and chondritic material aqueous alteration chemical models. Unlike on our planet, deep extraterrestrial ocean might also be interacting at depth with high pressure ices (e.g. III, V, VI, VI, X) which have different behavior compared to ice Ih. Unfortunately, the pressures and temperatures inside these hydrospheres differ significantly from the one found in Earth aqueous environments, so most of our current thermodynamic databases do not cover the range of conditions relevant for modeling realistically large icy worlds interiors. Recent experimental results have shown that the presence of solutes, and more particularly salts, in equilibrium with high pressure ices have large effects on the stability, buoyancy and chemistry of all the phases present at these extreme conditions. High pressure in-situ measurements using diamond anvil cell apparatus were operated both at the University of washington and at the European Synchrotron Radiation Facility on aqueous systems phase diagrams with Na-Mg-Cl-SO4 species, salt incorporation in high pressure ices and density inversions between the solid and the fluids. These results suggest a more complex picture of the interior structure, dynamic and chemical evolution of large icy worlds hydrospheres when solutes are taken into account, compared to current models mainly using pure water. Based on our in-situ experimental measurements, we propose the existence of new liquid environments at greater depths and the possibility of solid state transport of solute through the high pressure ices
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Global Precipitation Measurement Mission: Architecture and Mission Concept
Bundas, David
2005-01-01
The Global Precipitation Measurement (GPM) Mission is a collaboration between the National Aeronautics and Space Administration (NASA) and the Japanese Aerospace Exploration Agency (JAXA), and other partners, with the goal of monitoring the diurnal and seasonal variations in precipitation over the surface of the earth. These measurements will be used to improve current climate models and weather forecasting, and enable improved storm and flood warnings. This paper gives an overview of the mission architecture and addresses some of the key trades that have been completed, including the selection of the Core Observatory s orbit, orbit maintenance trades, and design issues related to meeting orbital debris requirements.
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Extensive deep vein thrombosis following prolonged gaming ('gamer's thrombosis'): a case report.
Chang, Hsien-Cheng Leon; Burbridge, Hayley; Wong, Conroy
2013-10-08
The average time spent playing video games is increasing. Prolonged immobility associated with gaming may therefore be an important risk factor for venous thromboembolism. We report a case of deep vein thrombosis associated with prolonged playing of PlayStation® games. A 31-year-old Caucasian man, an exterior painter, presented with a three-day history of left leg pain and swelling after playing PlayStation® games for almost eight hours a day for four consecutive days. Doppler ultrasound of the left leg confirmed extensive left leg deep venous thrombosis requiring thrombolysis and anticoagulation. Video gaming should be considered a risk factor for venous thromboembolism. Further studies are needed to estimate the degree of risk associated with prolonged periods of playing video games, and education for preventing venous thrombosis should be provided to gamers.
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Correlates of prolonged television viewing time in older Japanese men and women.
Kikuchi, Hiroyuki; Inoue, Shigeru; Sugiyama, Takemi; Owen, Neville; Oka, Koichiro; Shimomitsu, Teruichi
2013-03-09
In addition to insufficient moderate-to-vigorous physical activity (MVPA), prolonged sitting time is also a health risk for older adults. An understanding of population subgroups who have prolonged television viewing (TV) time, a predominant sedentary behavior, can aid in the development of relevant health promotion initiatives; however, few such studies have focused on older adults, the most sedentary segment of the population as a whole. The aim of this study is to examine the socio-demographic attributes associated with TV time among community-dwelling Japanese older men and women. A population-based, cross-sectional mail survey was used to collect data on TV time, MVPA, and socio-demographic characteristics. The survey was conducted from February through March 2010. Participants were 2700 community-dwelling older adults (aged 65-74 years, 50% men) who were randomly selected from the registry of residential addresses of three cities in Japan. Data from 1665 participants (mean age: 69.5 years, 52% men) who completed all variables for the present study were analyzed. Multivariate logistic regression analyses were used to calculate the odds ratios (ORs) of prolonged TV time (>2 hours/day) for each socio-demographic attribute, stratified by gender. Of the 1665 participants, 810 (48.6%) watched TV for more than 2 hours/day. The median television viewing time (25th, 75th percentile) was 2.00 (1.07, 3.50) hours/day. Prolonged TV time was associated with not in full-time employment, lower educational attainment, weight status, living in regional areas and low MVPA for the whole sample. For men, prolonged TV time was associated with lower educational attainment; (OR = 1.53, 95% CI: 1.12-2.07), underweight (OR = 1.63, 95% CI: 1.02-2.60), overweight (OR = 1.57, 95% CI: 1.11-2.21), and low MVPA (OR = 1.43, 95% CI: 1.02-2.02). For women, living in regional areas (OR = 2.02, 95% CI: 1.33-3.08), living alone (OR = 1.61, 95% CI: 1.03-2.49), not driving
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Prolonged Exposure Therapy For Post Traumatic Stress Disorder
Directory of Open Access Journals (Sweden)
Levent SÜTÇÝGÝL
2012-08-01
Full Text Available Post-traumatic Stress Disorder (PTSD is a psychiatric illness that usually develops after an event that threatens ones life and body integrity and it affects quality of life and impairs social functioning significantly. Many studies have shown therapeutic effect of cognitive behavioral therapies on posttraumatic stress disorder, so that these therapies take part in the first step of treatment guides. Exposure is a practice that is generally used to reduce pathological fear and related emotions common in posttraumatic stress disorder (PTSD and other anxiety disorders. During exposure, patients intentionally confront with feared objects, situations, thoughts and similar stimuli in order to reduce anxiety level. Exposure can be divided into two main techniques as in vivo exposure and imaginal exposure. Prolonged exposure therapy is a specialized treatment program configured for the treatment of posttraumatic stress disorder and it is based on emotional processing theory. Program is comprised of four main components: (a Psycho-education about trauma and posttraumatic disorders, (b Training for breathing exercises, (c repeated facing with objects, persons, situations and thoughts which causes re-experience about trauma, (d Patient are instructed for telling repeatedly and loudly about traumatic experiences . Prolonged exposure usually involves 9 to 12 sessions, each lasting about 60-90 minutes, administered once or twice a week. Prolonged exposure therapy was started to be implemented since the 1980s, during this period the effectiveness of the therapy has been shown in various empirical studies. [JCBPR 2012; 1(2.000: 98-104
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A review of Spacelab mission management approach
Craft, H. G., Jr.
1979-01-01
The Spacelab development program is a joint undertaking of the NASA and ESA. The paper addresses the initial concept of Spacelab payload mission management, the lessons learned, and modifications made as a result of the actual implementation of Spacelab Mission 1. The discussion covers mission management responsibilities, program control, science management, payload definition and interfaces, integrated payload mission planning, integration requirements, payload specialist training, payload and launch site integration, payload flight/mission operations, and postmission activities. After 3.5 years the outlined overall mission manager approach has proven to be most successful. The approach does allow the mission manager to maintain the lowest overall mission cost.
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Borowski, Stanley K.; McCurdy, David R.; Packard, Thomas W.
2014-01-01
The "fast conjunction" long surface stay mission option was selected for NASA's recent Mars Design Reference Architecture (DRA) 5.0 study because it provided adequate time at Mars (approx. 540 days) for the crew to explore the planet's geological diversity while also reducing the "1-way" transit times to and from Mars to approx. 6 months. Short transit times are desirable in order to reduce the debilitating physiological effects on the human body that can result from prolonged exposure to the zero-gravity (0-gE) and radiation environments of space. Recent measurements from the RAD detector attached to the Curiosity rover indicate that astronauts would receive a radiation dose of approx. 0.66 Sv (approx. 66 rem)-the limiting value established by NASA-during their 1-year journey in deep space. Proven nuclear thermal rocket (NTR) technology, with its high thrust and high specific impulse (Isp approx. 900 s), can cut 1-way transit times by as much as 50 percent by increasing the propellant capacity of the Mars transfer vehicle (MTV). No large technology scale-ups in engine size are required for these short transit missions either since the smallest engine tested during the Rover program-the 25 klbf "Pewee" engine is sufficient when used in a clustered arrangement of three to four engines. The "Copernicus" crewed MTV developed for DRA 5.0 is a 0-gE design consisting of three basic components: (1) the NTP stage (NTPS); (2) the crewed payload element; and (3) an integrated "saddle truss" and LH2 propellant drop tank assembly that connects the two elements. With a propellant capacity of approx. 190 t, Copernicus can support 1-way transit times ranging from approx. 150 to 220 days over the 15-year synodic cycle. The paper examines the impact on vehicle design of decreasing transit times for the 2033 mission opportunity. With a fourth "upgraded" SLS/HLV launch, an "in-line" LH2 tank element can be added to Copernicus allowing 1-way transit times of 130 days. To achieve 100
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Dukovany ASSET mission preparation
International Nuclear Information System (INIS)
Kouklik, I.
1996-01-01
We are in the final stages of the Dukovany ASSET mission 1996 preparation. I would like to present some of our recent experiences. Maybe they would be helpful to other plants, that host ASSET missions in future
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Dukovany ASSET mission preparation
Energy Technology Data Exchange (ETDEWEB)
Kouklik, I [NPP Dukovany (Czech Republic)
1997-12-31
We are in the final stages of the Dukovany ASSET mission 1996 preparation. I would like to present some of our recent experiences. Maybe they would be helpful to other plants, that host ASSET missions in future.
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Prolongation of rapacuronium neuromuscular blockade by clindamycin and magnesium.
Sloan, Paul A; Rasul, Mazhar
2002-01-01
We report a prolonged neuromuscular block with the nondepolarizing muscle relaxant rapacuronium in the presence of clindamycin. Even when using "short-acting" muscle relaxants, the anesthesiologist must routinely monitor the neuromuscular function.
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Güell, A.; Dupui, Ph.; Fanjaud, G.; Bes, A.; Moatti, J. P.; Gharrib, Cl.
The effects of prolonged bedrest in antiorthostatic position (-4° head down) on electrolyte balance were studied in 4 young volunteers. An increase was noted in sodium excretion during the first 4 days. Plasma renin activity and plasma aldosterone varied in parallel manner during the same period. Potassium balance and creatinine clearance were not significantly modified. In light of these data we feel that prolonged bedrest in antiorthostatic position constitutes an effective way to simulate on earth metabolic and hormonal modifications occurring in man under weightlessness conditions.
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Psychosocial interactions during ISS missions
Kanas, N. A.; Salnitskiy, V. P.; Ritsher, J. B.; Gushin, V. I.; Weiss, D. S.; Saylor, S. A.; Kozerenko, O. P.; Marmar, C. R.
2007-02-01
Based on anecdotal reports from astronauts and cosmonauts, studies of space analog environments on Earth, and our previous research on the Mir Space Station, a number of psychosocial issues have been identified that can lead to problems during long-duration space expeditions. Several of these issues were studied during a series of missions to the International Space Station. Using a mood and group climate questionnaire that was completed weekly by crewmembers in space and personnel in mission control, we found no evidence to support the presence of predicted decrements in well-being during the second half or in any specific quarter of the missions. The results did support the predicted displacement of negative feelings to outside supervisors among both crew and ground subjects. There were several significant differences in mood and group perceptions between Americans and Russians and between crewmembers and mission control personnel. Crewmembers related cohesion to the support role of their leader, and mission control personnel related cohesion to both the task and support roles of their leader. These findings are discussed with reference to future space missions.
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Diclofenac Prolongs Repolarization in Ventricular Muscle with Impaired Repolarization Reserve
Kristóf, Attila; Husti, Zoltán; Koncz, István; Kohajda, Zsófia; Szél, Tamás; Juhász, Viktor; Biliczki, Péter; Jost, Norbert; Baczkó, István; Papp, Julius Gy; Varró, András; Virág, László
2012-01-01
Background The aim of the present work was to characterize the electrophysiological effects of the non-steroidal anti-inflammatory drug diclofenac and to study the possible proarrhythmic potency of the drug in ventricular muscle. Methods Ion currents were recorded using voltage clamp technique in canine single ventricular cells and action potentials were obtained from canine ventricular preparations using microelectrodes. The proarrhythmic potency of the drug was investigated in an anaesthetized rabbit proarrhythmia model. Results Action potentials were slightly lengthened in ventricular muscle but were shortened in Purkinje fibers by diclofenac (20 µM). The maximum upstroke velocity was decreased in both preparations. Larger repolarization prolongation was observed when repolarization reserve was impaired by previous BaCl2 application. Diclofenac (3 mg/kg) did not prolong while dofetilide (25 µg/kg) significantly lengthened the QTc interval in anaesthetized rabbits. The addition of diclofenac following reduction of repolarization reserve by dofetilide further prolonged QTc. Diclofenac alone did not induce Torsades de Pointes ventricular tachycardia (TdP) while TdP incidence following dofetilide was 20%. However, the combination of diclofenac and dofetilide significantly increased TdP incidence (62%). In single ventricular cells diclofenac (30 µM) decreased the amplitude of rapid (IKr) and slow (IKs) delayed rectifier currents thereby attenuating repolarization reserve. L-type calcium current (ICa) was slightly diminished, but the transient outward (Ito) and inward rectifier (IK1) potassium currents were not influenced. Conclusions Diclofenac at therapeutic concentrations and even at high dose does not prolong repolarization markedly and does not increase the risk of arrhythmia in normal heart. However, high dose diclofenac treatment may lengthen repolarization and enhance proarrhythmic risk in hearts with reduced repolarization reserve. PMID:23300901
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Human exploration mission studies
Cataldo, Robert L.
1989-01-01
The Office of Exploration has established a process whereby all NASA field centers and other NASA Headquarters offices participate in the formulation and analysis of a wide range of mission strategies. These strategies were manifested into specific scenarios or candidate case studies. The case studies provided a systematic approach into analyzing each mission element. First, each case study must address several major themes and rationale including: national pride and international prestige, advancement of scientific knowledge, a catalyst for technology, economic benefits, space enterprise, international cooperation, and education and excellence. Second, the set of candidate case studies are formulated to encompass the technology requirement limits in the life sciences, launch capabilities, space transfer, automation, and robotics in space operations, power, and propulsion. The first set of reference case studies identify three major strategies: human expeditions, science outposts, and evolutionary expansion. During the past year, four case studies were examined to explore these strategies. The expeditionary missions include the Human Expedition to Phobos and Human Expedition to Mars case studies. The Lunar Observatory and Lunar Outpost to Early Mars Evolution case studies examined the later two strategies. This set of case studies established the framework to perform detailed mission analysis and system engineering to define a host of concepts and requirements for various space systems and advanced technologies. The details of each mission are described and, specifically, the results affecting the advanced technologies required to accomplish each mission scenario are presented.
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Prolonged ultraviolet light-induced erythema and the cutaneous carcinoma phenotype
International Nuclear Information System (INIS)
Tanenbaum, L.; Parrish, J.A.; Haynes, H.A.; Fitzpatrick, T.B.; Pathak, M.A.
1976-01-01
A considerable amount of evidence exists in support of the role of ultraviolet radiation as a major etiologic factor in human skin cancer, both melanoma and carcinoma types. On the basis of epidemiologic studies a phenotype has been described which helps to identify the persons who are more susceptible to skin cancer. In an attempt to further define this population, patients with cutaneous carcinoma and a normal control group were exposed to artificial ultraviolet light (UVL) and the erythema and tanning responses of each group were measured over a 21-day period. UVL-induced erythema was prolonged in a significantly higher percentage of patients with skin cancer than in control patients, lasting two to three weeks after single exposures to 6 and 8 times the patient's minimal erythema dose. The presence of prolonged erythema correlated with this history of previous skin cancer but did not correlate with other established risk factors for cutaneous carcinoma, i.e., fair skin, light hair and light eyes, easy sunburning and poor tanning, and Celtic ancestry. Prolonged erythema following UVL radiation may therefore represent an additional risk factor and help to identify the skin cancer-susceptible population
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Flight mission control for multiple spacecraft
Ryan, Robert E.
1990-10-01
A plan developed by the Jet Propulsion Laboratory for mission control of unmanned spacecraft is outlined. A technical matrix organization from which, in the past, project teams were formed to uniquely support a mission is replaced in this new plan. A cost effective approach was needed to make best use of limited resources. Mission control is a focal point operations and a good place to start a multimission concept. Co-location and sharing common functions are the keys to obtaining efficiencies at minimum additional risk. For the projects, the major changes are sharing a common operations area and having indirect control of personnel. The plan identifies the still direct link for the mission control functions. Training is a major element in this plan. Personnel are qualified for a position and certified for a mission. This concept is more easily accepted by new missions than the ongoing missions.
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Research from the NASA Twins Study and Omics in Support of Mars Missions
Kundrot, C.; Shelhamer, M.; Scott, G.
2015-01-01
The NASA Twins Study, NASA's first foray into integrated omic studies in humans, illustrates how an integrated omics approach can be brought to bear on the challenges to human health and performance on a Mars mission. The NASA Twins Study involves US Astronaut Scott Kelly and his identical twin brother, Mark Kelly, a retired US Astronaut. No other opportunity to study a twin pair for a prolonged period with one subject in space and one on the ground is available for the foreseeable future. A team of 10 principal investigators are conducting the Twins Study, examining a very broad range of biological functions including the genome, epigenome, transcriptome, proteome, metabolome, gut microbiome, immunological response to vaccinations, indicators of atherosclerosis, physiological fluid shifts, and cognition. A novel aspect of the study is the integrated study of molecular, physiological, cognitive, and microbiological properties. Major sample and data collection from both subjects for this study began approximately six months before Scott Kelly's one year mission on the ISS, continue while Scott Kelly is in flight and will conclude approximately six months after his return to Earth. Mark Kelly will remain on Earth during this study, in a lifestyle unconstrained by this study, thereby providing a measure of normal variation in the properties being studied. An overview of initial results and the future plans will be described as well as the technological and ethical issues raised for spaceflight studies involving omics.
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Accretion rate of extraterrestrial {sup 41}Ca in Antarctic snow samples
Energy Technology Data Exchange (ETDEWEB)
Gómez-Guzmán, J.M., E-mail: jose.gomez@ph.tum.de [Technische Universität München, Fakultät für Physik, James-Franck-Strasse 1, 85748 Garching (Germany); Bishop, S.; Faestermann, T.; Famulok, N.; Fimiani, L.; Hain, K.; Jahn, S.; Korschinek, G.; Ludwig, P. [Technische Universität München, Fakultät für Physik, James-Franck-Strasse 1, 85748 Garching (Germany); Rodrigues, D. [Laboratorio TANDAR, Comisión Nacional de Energía Atómica (Argentina)
2015-10-15
Interplanetary Dust Particles (IDPs) are small grains, generally less than a few hundred micrometers in size. Their main source is the Asteroid Belt, located at 3 AU from the Sun, between Mars and Jupiter. During their flight from the Asteroid Belt to the Earth they are irradiated by galactic and solar cosmic rays (GCR and SCR), thus radionuclides are formed, like {sup 41}Ca and {sup 53}Mn. Therefore, {sup 41}Ca (T{sub 1/2} = 1.03 × 10{sup 5} yr) can be used as a key tracer to determine the accretion rate of IDPs onto the Earth because there are no significant terrestrial sources for this radionuclide. The first step of this study consisted to calculate the production rate of {sup 41}Ca in IDPs accreted by the Earth during their travel from the Asteroid Belt. This production rate, used in accordance with the {sup 41}Ca/{sup 40}Ca ratios that will be measured in snow samples from the Antarctica will be used to calculate the amount of extraterrestrial material accreted by the Earth per year. There challenges for this project are, at first, the much longer time for the flight needed by the IDPs to travel from the Asteroid Belt to the Earth in comparison with the {sup 41}Ca half-life yields an early saturation for the {sup 41}Ca/{sup 40}Ca ratio, and second, the importance of selecting the correct sampling site to avoid a high influx of natural {sup 40}Ca, preventing dilution of the {sup 41}Ca/{sup 40}Ca ratio, the quantity measured by AMS.
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The gain of single-axis tracked panel according to extraterrestrial radiation
International Nuclear Information System (INIS)
Chang, T.P.
2009-01-01
In the present study, the gain in extraterrestrial radiation received by a single-axis tracked panel relative to a fixed panel was systematically analyzed over a specific period of time. The dynamic angle that the tracked panel should rotate by in order to follow the sun was derived through a series of spherical trigonometric procedures. The instantaneous incident angle of sunlight upon the panel was then calculated, assuming that the panel would simultaneously follow the sun's position. Thus, instantaneous increments of solar energy received by the tracked panel relative to the fixed panel are originally presented. The results show that the angle the tracked panel has to rotate by is 0 deg. at solar noon, and increases towards dawn or dusk. The incident angle of sunlight upon the tracked panel is always smaller than that upon the fixed panel, except at solar noon. As for panels installed with a yearly optimal tilt angle in Taipei, the gains are between 36.3% and 62.1% for four particular days of year, between 37.8% and 60.8% for the four seasons and 49.3% over the entire year. The amount of radiation collected by the tracked panel is enhanced as the maximum rotation angle is increased. The irradiation ratio of the tracked panel to the fixed panel is close to 1.5 for latitudes below 65 deg. and gradually increases for latitudes above this. The yearly optimal tilt angle of a south-facing fixed panel is approximately equal to 0.9 multiplied by the latitude (i.e. 0.9 x φ) for latitudes below 65 deg. and is about 56 + 0.4 x (φ - 65) otherwise
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NASA's Planetary Science Missions and Participations
Daou, Doris; Green, James L.
2017-04-01
NASA's Planetary Science Division (PSD) and space agencies around the world are collaborating on an extensive array of missions exploring our solar system. Planetary science missions are conducted by some of the most sophisticated robots ever built. International collaboration is an essential part of what we do. NASA has always encouraged international participation on our missions both strategic (ie: Mars 2020) and competitive (ie: Discovery and New Frontiers) and other Space Agencies have reciprocated and invited NASA investigators to participate in their missions. NASA PSD has partnerships with virtually every major space agency. For example, NASA has had a long and very fruitful collaboration with ESA. ESA has been involved in the Cassini mission and, currently, NASA funded scientists are involved in the Rosetta mission (3 full instruments, part of another), BepiColombo mission (1 instrument in the Italian Space Agency's instrument suite), and the Jupiter Icy Moon Explorer mission (1 instrument and parts of two others). In concert with ESA's Mars missions NASA has an instrument on the Mars Express mission, the orbit-ground communications package on the Trace Gas Orbiter (launched in March 2016) and part of the DLR/Mars Organic Molecule Analyzer instruments going onboard the ExoMars Rover (to be launched in 2018). NASA's Planetary Science Division has continuously provided its U.S. planetary science community with opportunities to include international participation on NASA missions too. For example, NASA's Discovery and New Frontiers Programs provide U.S. scientists the opportunity to assemble international teams and design exciting, focused planetary science investigations that would deepen the knowledge of our Solar System. The PSD put out an international call for instruments on the Mars 2020 mission. This procurement led to the selection of Spain and Norway scientist leading two instruments and French scientists providing a significant portion of another
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Cerebral ammonia uptake and accumulation during prolonged exercise in humans
DEFF Research Database (Denmark)
Nybo, Lars; Dalsgaard, Mads K.; Steensberg, Adam
2005-01-01
We evaluated whether peripheral ammonia production during prolonged exercise enhances the uptake and subsequent accumulation of ammonia within the brain. Two studies determined the cerebral uptake of ammonia (arterial and jugular venous blood sampling combined with Kety-Schmidt-determined cerebral...... blood flow; n = 5) and the ammonia concentration in the cerebrospinal fluid (CSF; n = 8) at rest and immediately following prolonged exercise either with or without glucose supplementation. There was a net balance of ammonia across the brain at rest and at 30 min of exercise, whereas 3 h of exercise...... exercise with glucose, and further to 16.1 ± 3.3 µM after the placebo trial (P
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Sustainable, Reliable Mission-Systems Architecture
O'Neil, Graham; Orr, James K.; Watson, Steve
2007-01-01
A mission-systems architecture, based on a highly modular infrastructure utilizing: open-standards hardware and software interfaces as the enabling technology is essential for affordable and sustainable space exploration programs. This mission-systems architecture requires (a) robust communication between heterogeneous system, (b) high reliability, (c) minimal mission-to-mission reconfiguration, (d) affordable development, system integration, and verification of systems, and (e) minimal sustaining engineering. This paper proposes such an architecture. Lessons learned from the Space Shuttle program and Earthbound complex engineered system are applied to define the model. Technology projections reaching out 5 years are mde to refine model details.
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308 Building deactivation mission analysis report
International Nuclear Information System (INIS)
Lund, D.P.
1995-01-01
This report presents the results of the 308 Building (Fuels Development Laboratory) Deactivation Project mission analysis. Hanford systems engineering (SE) procedures call for a mission analysis. The mission analysis is an important first step in the SE process. The functions and requirements to successfully accomplish this mission, the selected alternatives and products will later be defined using the SE process
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309 Building deactivation mission analysis report
International Nuclear Information System (INIS)
Lund, D.P.
1995-01-01
This report presents the results of the 309 Building (Plutonium Fuels Utilization Program) Deactivation Project mission analysis. Hanford systems engineering (SE) procedures call for a mission analysis. The mission analysis is an important first step in the SE process. The functions and requirements to successfully accomplish this mission, the selected alternatives and products will later be defined using the SE process
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Prolongation Structure of Semi-discrete Nonlinear Evolution Equations
International Nuclear Information System (INIS)
Bai Yongqiang; Wu Ke; Zhao Weizhong; Guo Hanying
2007-01-01
Based on noncommutative differential calculus, we present a theory of prolongation structure for semi-discrete nonlinear evolution equations. As an illustrative example, a semi-discrete model of the nonlinear Schroedinger equation is discussed in terms of this theory and the corresponding Lax pairs are also given.
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Crew Transportation System Design Reference Missions
Mango, Edward J.
2015-01-01
Contains summaries of potential design reference mission goals for systems to transport humans to andfrom low Earth orbit (LEO) for the Commercial Crew Program. The purpose of this document is to describe Design Reference Missions (DRMs) representative of the end-to-end Crew Transportation System (CTS) framework envisioned to successfully execute commercial crew transportation to orbital destinations. The initial CTS architecture will likely be optimized to support NASA crew and NASA-sponsored crew rotation missions to the ISS, but consideration may be given in this design phase to allow for modifications in order to accomplish other commercial missions in the future. With the exception of NASA’s mission to the ISS, the remaining commercial DRMs are notional. Any decision to design or scar the CTS for these additional non-NASA missions is completely up to the Commercial Provider. As NASA’s mission needs evolve over time, this document will be periodically updated to reflect those needs.
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Improving the Operations of the Earth Observing One Mission via Automated Mission Planning
Chien, Steve A.; Tran, Daniel; Rabideau, Gregg; Schaffer, Steve; Mandl, Daniel; Frye, Stuart
2010-01-01
We describe the modeling and reasoning about operations constraints in an automated mission planning system for an earth observing satellite - EO-1. We first discuss the large number of elements that can be naturally represented in an expressive planning and scheduling framework. We then describe a number of constraints that challenge the current state of the art in automated planning systems and discuss how we modeled these constraints as well as discuss tradeoffs in representation versus efficiency. Finally we describe the challenges in efficiently generating operations plans for this mission. These discussions involve lessons learned from an operations model that has been in use since Fall 2004 (called R4) as well as a newer more accurate operations model operational since June 2009 (called R5). We present analysis of the R5 software documenting a significant (greater than 50%) increase in the number of weekly observations scheduled by the EO-1 mission. We also show that the R5 mission planning system produces schedules within 15% of an upper bound on optimal schedules. This operational enhancement has created value of millions of dollars US over the projected remaining lifetime of the EO-1 mission.
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The European standard on planetary protection requirements.
Debus, André
2006-01-01
Since the beginning of solar system exploration, numerous spacecrafts have been sent towards others worlds, and one of the main goals of such missions is the search for extraterrestrial forms of life. It is known that, under certain conditions, some terrestrial entities are able to survive during cruises in space and that they may contaminate other planets (forward contamination). At another level, possible extraterrestrial life forms are unknown and their ability to contaminate the Earth's biosphere (back contamination) in the frame of sample return missions cannot be excluded. Article IX of the Outer Space Treaty (London/Washington, January 27, 1967) requires the preservation of planets and the Earth from contamination. All nations taking part in this Treaty must prevent forward and back contamination during missions exploring our solar system. Consequently, the United Nations (UN-COPUOS) has delegated COSPAR (Committee of Space Research) to take charge of planetary protection and, at present, all space-faring nations must comply with COSPAR policy and consequently with COSPAR planetary protection recommendations. Starting from these recommendations and the "CNES Planetary Protection Standard" document, a working group has been set up in the framework of the "European Cooperation for Space Standardization" (ECSS) to establish the main specifications for preventing cross-contamination between target bodies within the solar system and the Earth-moon system.
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Xu, Xianglong; Liu, Dengyuan; Rao, Yunshuang; Zeng, Huan; Zhang, Fan; Wang, Lu; Xie, Yaojie; Sharma, Manoj; Zhao, Yong
2018-02-27
Objectives: This study aimed to assess the prevalence of prolonged television, computer, and mobile phone viewing times and examined related sociodemographic factors among Chinese pregnant women. Methods: In this study, a cross-sectional survey was implemented among 2400 Chinese pregnant women in 16 hospitals of 5 provinces from June to August in 2015, and the response rate of 97.76%. We excluded women with serious complications and cognitive disorders. The women were asked about their television, computer, and mobile phone viewing during pregnancy. Prolonged television watching or computer viewing was defined as spending more than two hours on television or computer viewing per day. Prolonged mobile phone viewing was watching more than one hour on mobile phone per day. Results: Among 2345 pregnant women, about 25.1% reported prolonged television viewing, 20.6% reported prolonged computer viewing, and 62.6% reported prolonged mobile phone viewing. Pregnant women with long mobile phone viewing times were likely have long TV (Estimate = 0.080, Standard Error ( SE ) = 0.016, p women with long TV (Estimate = 0.134, SE = 0.027, p women with long TV viewing times were less likely to have long computer viewing times (Estimate = -0.032, SE = 0.015, p = 0.035), and pregnant women with long computer viewing times were less likely have long TV viewing times (Estimate = -0.059, SE = 0.028, p = 0.035). Pregnant women in their second pregnancy had lower prolonged computer viewing times than those in their first pregnancy (Odds Ratio (OR) 0.56, 95% Confidence Interval (CI) 0.42-0.74). Pregnant women in their second pregnancy were more likely have longer prolonged mobile phone viewing times than those in their first pregnancy ( OR 1.25, 95% CI 1.01-1.55). Conclusions: The high prevalence rate of prolonged TV, computer, and mobile phone viewing times was common for pregnant women in their first and second pregnancy. This study preliminarily explored the relationship between
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Use of Extraterrestrial Resources for Human Space Missions to Moon or Mars
Rapp, Donald
2013-01-01
This book carries out approximate estimates of the costs of implementing ISRU on the Moon and Mars. It is found that no ISRU process on the Moon has much merit. ISRU on Mars can save a great deal of mass, but there is a significant cost in prospecting for resources and validating ISRU concepts. Mars ISRU might have merit, but not enough data are available to be certain. In addition, this book provides a detailed review of various ISRU technologies. This includes three approaches for Mars ISRU based on processing only the atmosphere: solid oxide electrolysis, reverse water gas shift reaction (RWGS), and absorbing water vapor directly from the atmosphere. It is not clear that any of these technologies are viable although the RWGS seems to have the best chance. An approach for combining hydrogen with the atmospheric resource is chemically very viable, but hydrogen is needed on Mars. This can be approached by bringing hydrogen from Earth or obtaining water from near-surface water deposits in the soil. Bringing hy...
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Subtleties in practical application of prolonged infusion of β-lactam antibiotics.
De Waele, Jan J; Lipman, Jeffrey; Carlier, Mieke; Roberts, Jason A
2015-05-01
Prolonged infusion (PI) of β-lactam antibiotics is increasingly used in order to optimise antibiotic exposure in critically ill patients. Physicians are often not aware of a number of subtleties that may jeopardise the treatment. In this clinically based paper, we stress pragmatic issues, such as the importance of a loading dose before PI, and discuss a number of important practicalities that are mandatory to benefit from the pharmacokinetic advantages of prolonged β-lactam antibiotic administration. Copyright © 2015 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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Prolonged grief: where to after Diagnostic and Statistical Manual of Mental Disorders, 5th Edition?
Bryant, Richard A
2014-01-01
Although there is much evidence for the construct of prolonged grief, there was much controversy over the proposal to introduce a prolonged grief diagnosis into Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5), and it was finally rejected as a diagnosis in DSM-5. This review outlines the evidence for and against the diagnosis, and highlights the implications of the DSM-5 decision. Convergent evidence indicates that prolonged grief characterized by persistently severe yearning for the deceased is a distinct construct from bereavement-related depression and anxiety, is associated with marked functional impairment, is responsive to targeted treatments for prolonged grief, and has been validated across different cultures, age groups, and types of bereavement. Although DSM-5 has rejected the construct as a formal diagnosis, evidence continues to emerge on related mechanisms, including maladaptive appraisals, memory and attentional processes, immunological and arousal responses, and neural circuitry. It is most likely that the International Classification of Diseases (ICD-11) will introduce a diagnosis to recognize prolonged grief, even though DSM-5 has decided against this option. It is probable that the DSM-5 decision may result in more prolonged grief patients being incorrectly diagnosed with depression after bereavement and possibly incorrectly treated. The DSM-5 decision is unlikely to impact on future research agendas.
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The EXTASE thermal probe: Laboratory investigation and modelling of thermal properties
Kaufmann, E.; Knollenberg, J.; Kargl, G.; Koemle, N. I.
2011-10-01
In recent years space missions including landing devices are getting more important. These missions allow in-situ measurements and lead therefore to information on the structure and behavior of extraterrestrial surface and subsurface layers. Sensors used for this kind of missions have to be adapted to the non-terrestrial environment conditions. The better the properties of the single elements of each sensor are known, the more precise are the results from the data evaluation of in-situ measurements. We present the results of thermal conductivity measurements and simulations done for the fiber compound tube used as structural element for the heating segments of the MUPUS-PEN and EXTASE - a spin-off project of Rosetta/MUPUS.
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The Bible and mission in faith perspective: J.Hudson Taylor and the early China Inland Mission
Wigram, C.E.M.
2007-01-01
The thesis 'The Bible and Mission in Faith Perspective: J.Hudson Taylor and the Early China Inland Mission' by Christopher E.M. Wigram analysis the hermeneutical assumptions that underlay Hudson Taylor's approach to biblical interpretation, and the significance of his approach for the mission which
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The PROPEL Electrodynamic Tether Demonstration Mission
Bilen, Sven G.; Johnson, C. Les; Wiegmann, Bruce M.; Alexander, Leslie; Gilchrist, Brian E.; Hoyt, Robert P.; Elder, Craig H.; Fuhrhop, Keith P.; Scadera, Michael
2012-01-01
The PROPEL ("Propulsion using Electrodynamics") mission will demonstrate the operation of an electrodynamic tether propulsion system in low Earth orbit and advance its technology readiness level for multiple applications. The PROPEL mission has two primary objectives: first, to demonstrate the capability of electrodynamic tether technology to provide robust and safe, near-propellantless propulsion for orbit-raising, de-orbit, plane change, and station keeping, as well as to perform orbital power harvesting and formation flight; and, second, to fully characterize and validate the performance of an integrated electrodynamic tether propulsion system, qualifying it for infusion into future multiple satellite platforms and missions with minimal modification. This paper provides an overview of the PROPEL system and design reference missions; mission goals and required measurements; and ongoing PROPEL mission design efforts.
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Orbit determination for ISRO satellite missions
Rao, Ch. Sreehari; Sinha, S. K.
Indian Space Research Organisation (ISRO) has been successful in using the in-house developed orbit determination and prediction software for satellite missions of Bhaskara, Rohini and APPLE. Considering the requirements of satellite missions, software packages are developed, tested and their accuracies are assessed. Orbit determination packages developed are SOIP, for low earth orbits of Bhaskara and Rohini missions, ORIGIN and ODPM, for orbits related to all phases of geo-stationary missions and SEGNIP, for drift and geo-stationary orbits. Software is tested and qualified using tracking data of SIGNE-3, D5-B, OTS, SYMPHONIE satellites with the help of software available with CNES, ESA and DFVLR. The results match well with those available from these agencies. These packages have supported orbit determination successfully throughout the mission life for all ISRO satellite missions. Member-Secretary
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QTc-prolonging drugs and hospitalizations for cardiac arrhythmias
De Bruin, ML; Hoes, AW; Leufkens, HGM
2003-01-01
Cardiac arrhythmia as an adverse effect of noncardiac drugs has been an issue of growing importance during the past few years. In this population-based study, we evaluated the risk for serious cardiac arrhythmias during the use of several noncardiac QTc-prolonging drugs in day-to-day practice, and
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Wireless Monitoring of Changes in Crew Relations during Long-Duration Mission Simulation.
Directory of Open Access Journals (Sweden)
Bernd Johannes
Full Text Available Group structure and cohesion along with their changes over time play an important role in the success of missions where crew members spend prolonged periods of time under conditions of isolation and confinement. Therefore, an objective system for unobtrusive monitoring of crew cohesion and possible individual stress reactions is of high interest. For this purpose, an experimental wireless group structure (WLGS monitoring system integrated into a mobile psychophysiological system was developed. In the presented study the WLGS module was evaluated separately in six male subjects (27-38 years old participating in a 520-day simulated mission to Mars. Two days per week, each crew member wore a small sensor that registered the presence and distance of the sensors either worn by the other subjects or strategically placed throughout the isolation facility. The registration between two sensors was on average 91.0% in accordance. A correspondence of 95.7% with the survey video on day 475 confirmed external reliability. An integrated score of the "crew relation time index" was calculated and analyzed over time. Correlation analyses of a sociometric questionnaire (r = .35-.55, p< .05 and an ethological group approach (r = .45-.66, p < 05 provided initial evidence of the method's validity as a measure of cohesion when taking behavioral and activity patterns into account (e.g. only including activity phases in the afternoon. This confirms our assumption that the registered amount of time spent together during free time is associated with the intensity of personal relationships.
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Composable Mission Framework for Rapid End-to-End Mission Design and Simulation, Phase I
National Aeronautics and Space Administration — The innovation proposed here is the Composable Mission Framework (CMF) a model-based software framework that shall enable seamless continuity of mission design and...
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DEFF Research Database (Denmark)
Wichmann, Sine; Færk, Gitte; Bundgaard, Jens R.
2016-01-01
with prolonged duration of action to succinylcholine and mivacurium. Patients were studied if they had equivocal phenotypes on the basis of BChE activity, biochemical inhibitor reactions and with pedigree if possible. Complete nucleotide sequencing was performed to describe the genotype and pedigree was used......Introduction Mutations in the butyrylcholinesterase enzyme (BChE) can result in prolonged duration of action of the neuromuscular blocking agents, succinylcholine and mivacurium, as BChE hydrolyses these drugs. Hereditary low BChE activity can cause extensively prolonged apnoea during general...... anaesthesia when these drugs are used. The aim of this study was to describe novel mutations in the butyrylcholinesterase gene (BCHE) in patients who have experienced prolonged duration of action of mivacurium or succinylcholine. Methods The Danish Cholinesterase Research Unit registers patients...
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Extra-terrestrial igneous granites and related rocks: A review of their occurrence and petrogenesis
Bonin, Bernard
2012-11-01
The telluric planets and the asteroid belt display the same internal structure with a metallic inner core and a silicate outer shell. Experimental data and petrological evidence in silicate systems show that granite can be produced by extreme igneous differentiation through various types of igneous processes. On Moon, 4.4-3.9 Ga granite clasts display dry mineral assemblages. They correspond to at least 8 discrete intrusive events. Large K/Ca enrichment and low REE abundances in granite relative to KREEP are consistent with silicate liquid immiscibility, a process observed in melt inclusions within olivine of lunar basalts and in lunar meteorites. Steep-sided domes identified by remote sensing can represent intrusive or extrusive felsic formations. On Mars, black-and-white rhythmic layers observed on the Tharsis rise along the flanks of the peripheral scarps of the Tharsis Montes giant volcanoes suggest the possible eruption of felsic pyroclastites. Though no true granites were found so far in the Martian SNC meteorites, felsic glasses and mesostases were identified and a component close to terrestrial continental (granitic) crust is inferred from trace element and isotope systematics. Venus has suffered extensive volcanic resurfacing, whereas folded and faulted areas resemble terrestrial continents. Near large shield volcanoes, with dominant basaltic compositions, steep-sided domes have been interpreted as non-degassed silicic extrusions. The hypothesis of a granitic component is "tantalising". Extra-terrestrial granite is frequently found as clasts and mesostases in asteroidal meteorites. Porphyritic textures, with alkali feldspar crystals up to several centimetres in size, were observed in silicate enclaves within iron meteorites. In the chondrite clan, polymict breccias can contain granitic clasts, whose provenance is debated. One clast from the Adzhi-Bogdo meteorite yields a 4.53 ± 0.03 Ga Pb-Pb age, making it the oldest known granite in the solar system. The
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Allen, C.
2010-12-01
During the Year of the Solar System spacecraft will encounter two comets; orbit the asteroid Vesta, continue to explore Mars with rovers, and launch robotic explorers to the Moon and Mars. We have pieces of all these worlds in our laboratories. Extensive information about these unique materials, as well as actual lunar samples and meteorites, is available for display and education. The Johnson Space Center (JSC) curates NASA's extraterrestrial samples to support research, education, and public outreach. At the current time JSC curates five types of extraterrestrial samples: Moon rocks and soils collected by the Apollo astronauts Meteorites collected on US expeditions to Antarctica (including rocks from the Moon, Mars, and many asteroids including Vesta) “Cosmic dust” (asteroid and comet particles) collected by high-altitude aircraft Solar wind atoms collected by the Genesis spacecraft Comet and interstellar dust particles collected by the Stardust spacecraft These rocks, soils, dust particles, and atoms continue to be studied intensively by scientists around the world. Descriptions of the samples, research results, thousands of photographs, and information on how to request research samples are on the JSC Curation website: http://curator.jsc.nasa.gov/ NASA is eager for scientists and the public to have access to these exciting samples through our various loan procedures. NASA provides a limited number of Moon rock samples for either short-term or long-term displays at museums, planetariums, expositions, and professional events that are open to the public. The JSC Public Affairs Office handles requests for such display samples. Requestors should apply in writing to Mr. Louis Parker, JSC Exhibits Manager. He will advise successful applicants regarding provisions for receipt, display, and return of the samples. All loans will be preceded by a signed loan agreement executed between NASA and the requestor's organization. Email address: louis.a.parker@nasa.gov Sets
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Depressive disorders during weaning from prolonged mechanical ventilation.
Jubran, Amal; Lawm, Gerald; Kelly, Joanne; Duffner, Lisa A; Gungor, Gokay; Collins, Eileen G; Lanuza, Dorothy M; Hoffman, Leslie A; Tobin, Martin J
2010-05-01
Patients who require mechanical ventilation are at risk of emotional stress because of total dependence on a machine for breathing. The stress may negatively impact ventilator weaning and survival. The purpose of this study was to determine whether depressive disorders in patients being weaned from prolonged mechanical ventilation are linked to weaning failure and decreased survival. A prospective study of 478 consecutive patients transferred to a long-term acute care hospital for weaning from prolonged ventilation was undertaken. A clinical psychologist conducted a psychiatric interview to assess for the presence of depressive disorders. Of the 478 patients, 142 had persistent coma or delirium and were unable to be evaluated for depressive disorders. Of the remaining 336 patients, 142 (42%) were diagnosed with depressive disorders. In multivariate analysis, co-morbidity score [odds ratio (OR), 1.23; P = 0.007], functional dependence before the acute illness (OR, 1.70, P = 0.03) and history of psychiatric disorders (OR, 3.04, P = 0.0001) were independent predictors of depressive disorders. The rate of weaning failure was higher in patients with depressive disorders than in those without such disorders (61 vs. 33%, P = 0.0001), as was mortality (24 vs. 10%, P = 0.0008). The presence of depressive disorders was independently associated with mortality (OR, 4.3; P = 0.0002); age (OR, 1.06; P = 0.001) and co-morbidity score (OR, 1.24; P = 0.02) also predicted mortality. Depressive disorders were diagnosed in 42% of patients who were being weaned from prolonged ventilation. Patients with depressive disorders were more likely to experience weaning failure and death.
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Tanzi, Maria G; Undre, Nasrullah; Keirns, James; Fitzsimmons, William E; Brown, Malcolm; First, M Roy
2016-08-01
Prolonged-release tacrolimus was developed as a once-daily formulation with ethylcellulose as the excipient, resulting in slower release and reduction in peak concentration (Cmax ) for a given dose compared with immediate-release tacrolimus, which is administered twice daily. This manuscript reviews pharmacokinetic information on prolonged-release tacrolimus in healthy subjects, in transplant recipients converted from immediate-release tacrolimus, and in de novo kidney and liver transplant recipients. As with the immediate-release formulation, prolonged-release tacrolimus shows a strong correlation between trough concentration (Cmin ) and area under the 24-hour time-concentration curve (AUC24 ), indicating that trough whole blood concentrations provide an accurate measure of drug exposure. We present the pharmacokinetic similarities and differences between the two formulations, so that prescribing physicians will have a better understanding of therapeutic drug monitoring in patients receiving prolonged-release tacrolimus. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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Diclofenac prolongs repolarization in ventricular muscle with impaired repolarization reserve.
Directory of Open Access Journals (Sweden)
Attila Kristóf
Full Text Available BACKGROUND: The aim of the present work was to characterize the electrophysiological effects of the non-steroidal anti-inflammatory drug diclofenac and to study the possible proarrhythmic potency of the drug in ventricular muscle. METHODS: Ion currents were recorded using voltage clamp technique in canine single ventricular cells and action potentials were obtained from canine ventricular preparations using microelectrodes. The proarrhythmic potency of the drug was investigated in an anaesthetized rabbit proarrhythmia model. RESULTS: Action potentials were slightly lengthened in ventricular muscle but were shortened in Purkinje fibers by diclofenac (20 µM. The maximum upstroke velocity was decreased in both preparations. Larger repolarization prolongation was observed when repolarization reserve was impaired by previous BaCl(2 application. Diclofenac (3 mg/kg did not prolong while dofetilide (25 µg/kg significantly lengthened the QT(c interval in anaesthetized rabbits. The addition of diclofenac following reduction of repolarization reserve by dofetilide further prolonged QT(c. Diclofenac alone did not induce Torsades de Pointes ventricular tachycardia (TdP while TdP incidence following dofetilide was 20%. However, the combination of diclofenac and dofetilide significantly increased TdP incidence (62%. In single ventricular cells diclofenac (30 µM decreased the amplitude of rapid (I(Kr and slow (I(Ks delayed rectifier currents thereby attenuating repolarization reserve. L-type calcium current (I(Ca was slightly diminished, but the transient outward (I(to and inward rectifier (I(K1 potassium currents were not influenced. CONCLUSIONS: Diclofenac at therapeutic concentrations and even at high dose does not prolong repolarization markedly and does not increase the risk of arrhythmia in normal heart. However, high dose diclofenac treatment may lengthen repolarization and enhance proarrhythmic risk in hearts with reduced repolarization reserve.
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Centralized mission planning and scheduling system for the Landsat Data Continuity Mission
Kavelaars, Alicia; Barnoy, Assaf M.; Gregory, Shawna; Garcia, Gonzalo; Talon, Cesar; Greer, Gregory; Williams, Jason; Dulski, Vicki
2014-01-01
Satellites in Low Earth Orbit provide missions with closer range for studying aspects such as geography and topography, but often require efficient utilization of space and ground assets. Optimizing schedules for these satellites amounts to a complex planning puzzle since it requires operators to face issues such as discontinuous ground contacts, limited onboard memory storage, constrained downlink margin, and shared ground antenna resources. To solve this issue for the Landsat Data Continuity Mission (LDCM, Landsat 8), all the scheduling exchanges for science data request, ground/space station contact, and spacecraft maintenance and control will be coordinated through a centralized Mission Planning and Scheduling (MPS) engine, based upon GMV’s scheduling system flexplan9 . The synchronization between all operational functions must be strictly maintained to ensure efficient mission utilization of ground and spacecraft activities while working within the bounds of the space and ground resources, such as Solid State Recorder (SSR) and available antennas. This paper outlines the functionalities that the centralized planning and scheduling system has in its operational control and management of the Landsat 8 spacecraft.
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Ruangkriengsin, Darat; Phisalprapa, Pochamana
2014-03-01
Unnecessary days of prolonged hospitalization may lead to the increase in hospital-related complications and costs, especially in tertiary care center Currently, there have not been many studies about the causes of prolonged hospitalization. Some identified causes could, however, be prevented and improved. To identify the prevalence, causes, predictive factors, prognosis, and economic burden of prolonged hospitalization in patients who had been in general internal medicine wards of the tertiary care center for 7 days or more. Retrospective chart review study was conducted among all patients who were admitted for 7 days or more in general internal medicine wards of Siriraj Hospital, the largest tertiary care center in Thailand. The period of this study was from 1 August 2012 to 30 September 2012. Demographic data, principle diagnosis, comorbid diseases, complications, discharge status, total costs of admission and percentage of reimbursement were collected. The causes of prolonged hospitalization at day 7, 14, 30, and 90 were assessed. Five hundred and sixty-two charts were reviewed. The average length of stay was 25.9 days. The two most common causes of prolonged admission at day 7 were treatment of main diagnosed disease with stable condition (27.6%) and waiting for completion of intravenous antibiotics administration with stable condition (19.5%). The causes of prolonged hospitalization at day 14 were unstable condition from complications (22.6%) and those waiting for completion of intravenous antibiotics administration with stable condition (15.8%). The causes of prolonged admission at day 30 were unstable conditions from complications (25.6%), difficulty weaning or ventilator dependence (17.6%), and caregiver problems (15.2%). The causes of prolonged hospitalization at day 90 were unstable condition from complications (30.0%), caregiver problems (30.0%), and palliative care (25.0%). Poor outcomes were shown in the patients admitted more than 90 days. Percentage
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Prolonged Exposure: a Rapid Treatment for Phobias
Watson, J. P.; Gaind, R.; Marks, I. M.
1971-01-01
Ten adult patients with long-standing specific phobias were treated by prolonged continuous exposure to their phobic objects in fantasy and reality without avoidance. All patients were greatly helped by four to five hours' treatment in two or three sessions, and all improved more after practice than after imaginal sessions. The treatment method is more economical and efficient than other methods described so far. PMID:5539135
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AN OPPORTUNISTIC SEARCH FOR EXTRATERRESTRIAL INTELLIGENCE (SETI) WITH THE MURCHISON WIDEFIELD ARRAY
Energy Technology Data Exchange (ETDEWEB)
Tingay, S. J.; Tremblay, C.; Walsh, A.; Urquhart, R. [International Centre for Radio Astronomy Research (ICRAR), Curtin University, Bentley, WA 6102 (Australia)
2016-08-20
A spectral line image cube generated from 115 minutes of MWA data that covers a field of view of 400 sq, deg. around the Galactic Center is used to perform the first Search for ExtraTerrestrial Intelligence (SETI) with the Murchison Widefield Array (MWA). Our work constitutes the first modern SETI experiment at low radio frequencies, here between 103 and 133 MHz, paving the way for large-scale searches with the MWA and, in the future, the low-frequency Square Kilometre Array. Limits of a few hundred mJy beam{sup −1} for narrowband emission (10 kHz) are derived from our data, across our 400 sq. deg. field of view. Within this field, 45 exoplanets in 38 planetary systems are known. We extract spectra at the locations of these systems from our image cube to place limits on the presence of narrow line emission from these systems. We then derive minimum isotropic transmitter powers for these exoplanets; a small handful of the closest objects (10 s of pc) yield our best limits of order 10{sup 14} W (Equivalent Isotropic Radiated Power). These limits lie above the highest power directional transmitters near these frequencies currently operational on Earth. A SETI experiment with the MWA covering the full accessible sky and its full frequency range would require approximately one month of observing time. The MWA frequency range, its southern hemisphere location on an extraordinarily radio quiet site, its very large field of view, and its high sensitivity make it a unique facility for SETI.
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Heemskerk, Charlotte P.M.; Woldman, Evelien; Pereboom, Marieke; van der Hoeven, Ruud T M; Mantel-Teeuwisse, Aukje; Van Gemeren, Claudia; Becker, Matthijs Lambertus
2017-01-01
PURPOSE: Ciprofloxacin may prolong the QT interval and increase the risk of Torsade de Pointes (TdP). Intravenous administration of ciprofloxacin in patients with additional risks may elevate the risk of QTc interval prolongation. We prospectively assessed whether intravenous ciprofloxacin prolongs
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Spacelab Mission Implementation Cost Assessment (SMICA)
Guynes, B. V.
1984-01-01
A total savings of approximately 20 percent is attainable if: (1) mission management and ground processing schedules are compressed; (2) the equipping, staffing, and operating of the Payload Operations Control Center is revised, and (3) methods of working with experiment developers are changed. The development of a new mission implementation technique, which includes mission definition, experiment development, and mission integration/operations, is examined. The Payload Operations Control Center is to relocate and utilize new computer equipment to produce cost savings. Methods of reducing costs by minimizing the Spacelab and payload processing time during pre- and post-mission operation at KSC are analyzed. The changes required to reduce costs in the analytical integration process are studied. The influence of time, requirements accountability, and risk on costs is discussed. Recommendation for cost reductions developed by the Spacelab Mission Implementation Cost Assessment study are listed.
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Influence of prolonged cold ischemia in renal transplantation.
Vliet, J.A. van der; Warle, M.C.; Cheung, C.L.; Teerenstra, S.; Hoitsma, A.J.
2011-01-01
van der Vliet JA, Warle MC, Cheung CLS, Teerenstra S, Hoitsma AJ. Influence of prolonged cold ischemia in renal transplantation. Clin Transplant 2011: 25: E612-E616. (c) 2011 John Wiley & Sons A/S. Abstract: Aim: To determine to what extent current cold ischemia times (CITs) affect the results of
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Effect Of Prolonged Monocular Occlusion On Latent Nystagms
H.J. Simonsz (Huib); G. Kommerell (Guntram)
1992-01-01
textabstractThe authors recorded nystagmus during seeing with one eye in eight patients with latent nystagmus (LN) before and after two or three days of prolonged occlusion of the better eye (POBE). Before POBE, the slow-phase speed of the nystagmus (SPS) was usually higher when the better eye was
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Spacelab life sciences 2 post mission report
Buckey, Jay C.
1994-01-01
Jay C. Buckey, M.D., Assistant Professor of Medicine at The University of Texas Southwestern Medical Center at Dallas served as an alternate payload specialist astronaut for the Spacelab Life Sciences 2 Space Shuttle Mission from January 1992 through December 1993. This report summarizes his opinions on the mission and offers suggestions in the areas of selection, training, simulations, baseline data collection and mission operations. The report recognizes the contributions of the commander, payload commander and mission management team to the success of the mission. Dr. Buckey's main accomplishments during the mission are listed.
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Energy Technology Data Exchange (ETDEWEB)
Boisson, P; Huet, Ph; Mingasson, J
2000-06-01
The aim of the 'Granite' collegial mission of dialogue is to inform the French authorities, associations and population about the project of construction of an underground laboratory for the study of the disposal of high level and long-life radioactive wastes in a granitic environment. The aim of the dialogue was not to select a site but to collect the public reactions and advices about such a project. However, such a dialogue has partially failed because of a misunderstanding of the population about the aims of the mission. However, the mission has collected many point of views and questions which are developed in this report. The first and second chapters recall the process of the mission and its progress, while a third chapter stresses on the questions asked by the public and which concern the fear of nuclear wastes and the incompatibility between the disposal of wastes and the socio-economical development of the region concerned. Thanks to the lessons drawn from this experience, the mission has formulated some recommendations (chapter 4) concerning the need for a better information of the population about any topic in relation with the radioactive wastes. Some complementary information is provided in appendixes. (J.S.)
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Secondary bacteraemia in adult patients with prolonged dengue fever.
Premaratna, R; Dissanayake, D; Silva, F H D S; Dassanayake, M; de Silva, H J
2015-03-01
Although dengue management guidelines do not advice on use of antibiotics in dengue shock syndrome, unrecognised bactraemia is likely to contribute to morbidity and mortality. To assess the occurance of secondary bacteraemia in adult patients with prolonged dengue fever. A prospective study was conducted recruiting patients with confirmed acute dengue infection who had prolonged fever (>5 days). Two sets of blood cultures were taken in such patients prior to institution of antibiotic therapy. Demographic, clinical, haematological and biochemical parameters were recorded. Development of ascites and pleural effusions were detected using ultrasonography. Fourty patients (52.5% males) with a mean age of 29.8 years (SD 13.6) were studied. The average duration of fever was 7.9 days (SD 1.8). Ten patients (25%) had bacterial isolates in their blood cultures; Staphylococcus aureus (n=2), coliforms (n=3), pseudomonas (n=1) and 4 had mixed growths. The culture positive group had severe body aches at admission and higher fever, third space fluid accumulation, a significant drop in platelets and a higher CRP. A quarter of dengue patients with prolonged fever had a bacterial isolate. Culture positive patients appeared more ill with body aches and had higher degrees of fever during the latter part of the illness. Increased vascular permeability may predispose to bacterial seepage into blood. Although white cell count is not helpful in detecting bacteraemia, low platelet count and elevation of CRP seem to be helpful.
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KEPLER Mission: development and overview
International Nuclear Information System (INIS)
Borucki, William J
2016-01-01
The Kepler Mission is a space observatory launched in 2009 by NASA to monitor 170 000 stars over a period of four years to determine the frequency of Earth-size and larger planets in and near the habitable zone of Sun-like stars, the size and orbital distributions of these planets, and the types of stars they orbit. Kepler is the tenth in the series of NASA Discovery Program missions that are competitively-selected, PI-directed, medium-cost missions. The Mission concept and various instrument prototypes were developed at the Ames Research Center over a period of 18 years starting in 1983. The development of techniques to do the 10 ppm photometry required for Mission success took years of experimentation, several workshops, and the exploration of many ‘blind alleys’ before the construction of the flight instrument. Beginning in 1992 at the start of the NASA Discovery Program, the Kepler Mission concept was proposed five times before its acceptance for mission development in 2001. During that period, the concept evolved from a photometer in an L2 orbit that monitored 6000 stars in a 50 sq deg field-of-view (FOV) to one that was in a heliocentric orbit that simultaneously monitored 170 000 stars with a 105 sq deg FOV. Analysis of the data to date has detected over 4600 planetary candidates which include several hundred Earth-size planetary candidates, over a thousand confirmed planets, and Earth-size planets in the habitable zone (HZ). These discoveries provide the information required for estimates of the frequency of planets in our galaxy. The Mission results show that most stars have planets, many of these planets are similar in size to the Earth, and that systems with several planets are common. Although planets in the HZ are common, many are substantially larger than Earth. (review article)
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Inhibition of spontaneous recovery of fear by mGluR5 after prolonged extinction training.
Directory of Open Access Journals (Sweden)
Sheng-Chun Mao
Full Text Available Fear behavior is vital for survival and involves learning contingent associations of non-threatening cues with aversive stimuli. In contrast, excessive levels of fear can be maladaptive and lead to anxiety disorders. Generally, extensive sessions of extinction training correlates with reduced spontaneous recovery. The molecular mechanisms underlying the long-term inhibition of fear recovery following repeated extinction training are not fully understood. Here we show that in rats, prolonged extinction training causes greater reduction in both fear-potentiated startle and spontaneous recovery. This effect was specifically blocked by metabotropic glutamate receptor 5 (mGluR5, but not by mGluR1 antagonists and by a protein synthesis inhibitor. Similar inhibition of memory recovery following prolonged extinction training was also observed in mice. In agreement with the instrumental role of mGluR5 in the prolonged inhibition of fear recovery, we found that FMR1-/- mice which exhibit enhanced mGluR5-mediated signaling exhibit lower spontaneous recovery of fear after extinction training than wild-type littermates. At the molecular level, we discovered that prolonged extinction training reversed the fear conditioning-induced increase in surface expression of GluR1, AMPA/NMDA ratio, postsynaptic density-95 (PSD-95 and synapse-associated protein-97 (SAP97. Accordingly, delivery of Tat-GluR2(3Y, a synthetic peptide that blocks AMPA receptor endocytosis, inhibited prolonged extinction training-induced inhibition of fear recovery. Together, our results demonstrate that prolonged extinction training results in the mGluR5-dependent long-term inhibition of fear recovery. This effect may involve the degradation of original memory and may explain the beneficial effects of prolonged exposure therapy for the treatment of phobias.
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Inhibition of spontaneous recovery of fear by mGluR5 after prolonged extinction training.
Mao, Sheng-Chun; Chang, Chih-Hua; Wu, Chia-Chen; Orejarena, M Juliana; Orejanera, Maria Juliana; Manzoni, Olivier J; Gean, Po-Wu
2013-01-01
Fear behavior is vital for survival and involves learning contingent associations of non-threatening cues with aversive stimuli. In contrast, excessive levels of fear can be maladaptive and lead to anxiety disorders. Generally, extensive sessions of extinction training correlates with reduced spontaneous recovery. The molecular mechanisms underlying the long-term inhibition of fear recovery following repeated extinction training are not fully understood. Here we show that in rats, prolonged extinction training causes greater reduction in both fear-potentiated startle and spontaneous recovery. This effect was specifically blocked by metabotropic glutamate receptor 5 (mGluR5), but not by mGluR1 antagonists and by a protein synthesis inhibitor. Similar inhibition of memory recovery following prolonged extinction training was also observed in mice. In agreement with the instrumental role of mGluR5 in the prolonged inhibition of fear recovery, we found that FMR1-/- mice which exhibit enhanced mGluR5-mediated signaling exhibit lower spontaneous recovery of fear after extinction training than wild-type littermates. At the molecular level, we discovered that prolonged extinction training reversed the fear conditioning-induced increase in surface expression of GluR1, AMPA/NMDA ratio, postsynaptic density-95 (PSD-95) and synapse-associated protein-97 (SAP97). Accordingly, delivery of Tat-GluR2(3Y), a synthetic peptide that blocks AMPA receptor endocytosis, inhibited prolonged extinction training-induced inhibition of fear recovery. Together, our results demonstrate that prolonged extinction training results in the mGluR5-dependent long-term inhibition of fear recovery. This effect may involve the degradation of original memory and may explain the beneficial effects of prolonged exposure therapy for the treatment of phobias.
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Survival of a microbial soil community under Martian conditions
Hansen, A. A.; Noernberg, P.; Merrison, J.; Lomstein, B. Aa.; Finster, K. W.
2003-04-01
Because of the similarities between Earth and Mars early history the hypothesis was forwarded that Mars is a site where extraterrestrial life might have and/or may still occur(red). Sample-return missions are planned by NASA and ESA to test this hypothesis. The enormous economic costs and the logistic challenges of these missions make earth-based model facilities inevitable. The Mars simulation system at University of Aarhus, Denmark allows microbiological experiments under Mars analogue conditions. Thus detailed studies on the effect of Mars environmental conditions on the survival and the activity of a natural microbial soil community were carried out. Changes in the soil community were determined with a suite of different approaches: 1) total microbial respiration activity was investigated with 14C-glucose, 2) the physiological profile was investigated by the EcoLog-system, 3) colony forming units were determined by plate counts and 4) the microbial diversity on the molecular level was accessed with Denaturing Gradient Gel Electrophoresis. The simulation experiments showed that a part of the bacterial community survived Martian conditions corresponding to 9 Sol. These and future simulation experiments will contribute to our understanding of the possibility for extraterrestrial and terrestrial life on Mars.
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IRIS Mission Operations Director's Colloquium
Carvalho, Robert; Mazmanian, Edward A.
2014-01-01
Pursuing the Mysteries of the Sun: The Interface Region Imaging Spectrograph (IRIS) Mission. Flight controllers from the IRIS mission will present their individual experiences on IRIS from development through the first year of flight. This will begin with a discussion of the unique nature of IRISs mission and science, and how it fits into NASA's fleet of solar observatories. Next will be a discussion of the critical roles Ames contributed in the mission including spacecraft and flight software development, ground system development, and training for launch. This will be followed by experiences from launch, early operations, ongoing operations, and unusual operations experiences. The presentation will close with IRIS science imagery and questions.
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MMPM - Mars MetNet Precursor Mission
Harri, A.-M.; Schmidt, W.; Pichkhadze, K.; Linkin, V.; Vazquez, L.; Uspensky, M.; Polkko, J.; Genzer, M.; Lipatov, A.; Guerrero, H.; Alexashkin, S.; Haukka, H.; Savijarvi, H.; Kauhanen, J.
2008-09-01
We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2009/2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Detailed characterization of the Martian atmospheric circulation patterns, boundary layer phenomena, and climatology cycles, require simultaneous in-situ measurements by a network of observation posts on the Martian surface. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe technologies have been developed and the critical subsystems have been qualified to meet the Martian environmental and functional conditions. Prototyping of the payload instrumentation with final dimensions was carried out in 2003-2006.This huge development effort has been fulfilled in collaboration between the Finnish Meteorological Institute (FMI), the Russian Lavoschkin Association (LA) and the Russian Space Research Institute (IKI) since August 2001. Currently the INTA (Instituto Nacional de Técnica Aeroespacial) from Spain is also participating in the MetNet payload development. To understand the behavior and dynamics of the Martian atmosphere, a wealth of simultaneous in situ observations are needed on varying types of Martian orography, terrain and altitude spanning all latitudes and longitudes. This will be performed by the Mars MetNet Mission. In addition to the science aspects the
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Directory of Open Access Journals (Sweden)
Xianglong Xu
2018-02-01
Full Text Available Objectives: This study aimed to assess the prevalence of prolonged television, computer, and mobile phone viewing times and examined related sociodemographic factors among Chinese pregnant women. Methods: In this study, a cross-sectional survey was implemented among 2400 Chinese pregnant women in 16 hospitals of 5 provinces from June to August in 2015, and the response rate of 97.76%. We excluded women with serious complications and cognitive disorders. The women were asked about their television, computer, and mobile phone viewing during pregnancy. Prolonged television watching or computer viewing was defined as spending more than two hours on television or computer viewing per day. Prolonged mobile phone viewing was watching more than one hour on mobile phone per day. Results: Among 2345 pregnant women, about 25.1% reported prolonged television viewing, 20.6% reported prolonged computer viewing, and 62.6% reported prolonged mobile phone viewing. Pregnant women with long mobile phone viewing times were likely have long TV (Estimate = 0.080, Standard Error (SE = 0.016, p < 0.001 and computer viewing times (Estimate = 0.053, SE = 0.022, p = 0.015. Pregnant women with long TV (Estimate = 0.134, SE = 0.027, p < 0.001 and long computer viewing times (Estimate = 0.049, SE = 0.020, p = 0.015 were likely have long mobile phone viewing times. Pregnant women with long TV viewing times were less likely to have long computer viewing times (Estimate = −0.032, SE = 0.015, p = 0.035, and pregnant women with long computer viewing times were less likely have long TV viewing times (Estimate = −0.059, SE = 0.028, p = 0.035. Pregnant women in their second pregnancy had lower prolonged computer viewing times than those in their first pregnancy (Odds Ratio (OR 0.56, 95% Confidence Interval (CI 0.42–0.74. Pregnant women in their second pregnancy were more likely have longer prolonged mobile phone viewing times than those in their first pregnancy (OR 1.25, 95
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Mission to the Solar System: Exploration and Discovery. A Mission and Technology Roadmap
Gulkis, S. (Editor); Stetson, D. S. (Editor); Stofan, E. R. (Editor)
1998-01-01
Solar System exploration addresses some of humanity's most fundamental questions: How and when did life form on Earth? Does life exist elsewhere in the Solar System or in the Universe? - How did the Solar System form and evolve in time? - What can the other planets teach us about the Earth? This document describes a Mission and Technology Roadmap for addressing these and other fundamental Solar System Questions. A Roadmap Development Team of scientists, engineers, educators, and technologists worked to define the next evolutionary steps in in situ exploration, sample return, and completion of the overall Solar System survey. Guidelines were to "develop aa visionary, but affordable, mission and technology development Roadmap for the exploration of the Solar System in the 2000 to 2012 timeframe." The Roadmap provides a catalog of potential flight missions. (Supporting research and technology, ground-based observations, and laboratory research, which are no less important than flight missions, are not included in this Roadmap.)
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Prolonged bone marrow T1-relaxation in patients with polycythemia vera
DEFF Research Database (Denmark)
Jensen, K E; Grube, T; Thomsen, C
1988-01-01
In vitro as well as in vivo studies have shown prolonged T1 relaxation times in patients with acute leukemia. The mechanism behind this finding is not known. In order to evaluate if this was specific for leukemia we examined eight patients with polycythemia vera, representing a condition with a r......In vitro as well as in vivo studies have shown prolonged T1 relaxation times in patients with acute leukemia. The mechanism behind this finding is not known. In order to evaluate if this was specific for leukemia we examined eight patients with polycythemia vera, representing a condition...
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Prognostic Significance Of QT Interval Prolongation In Adult ...
African Journals Online (AJOL)
Prognostic survival studies for heart-rate corrected QT interval in patients with chronic heart failure are few; although these patients are known to have a high risk of sudden cardiac death. This study was aimed at determining the mortality risk associated with prolonged QTc in Nigerians with heart failure. Ninety-six ...
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Mission Critical Occupation (MCO) Charts
Office of Personnel Management — Agencies report resource data and targets for government-wide mission critical occupations and agency specific mission critical and/or high risk occupations. These...
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International Nuclear Information System (INIS)
Kwong, Dora L.W.; Sham, Jonathan S.T.; Chua, Daniel T.T.; Choy, Damon T.K.; Au, Gordon K.H.; Wu, P.M.
1997-01-01
Purpose: The effect of interruptions and prolonged overall treatment time in radiotherapy for nasopharyngeal carcinoma and the significance of timing of interruption was investigated. Methods and Materials: Treatment records of 229 patients treated with continuous course (CC) and 567 patients treated with split course (SC) radiotherapy for nonmetastatic NPC were reviewed. Overall treatment time without inclusion of time for boost was calculated. Treatment that extended 1 week beyond scheduled time was considered prolonged. Outcome in patients who completed treatment 'per schedule' were compared with those who had 'prolonged' treatment. Because of known patient selection bias between CC and SC, patients on the two schedules were analyzed separately. Multivariate analysis was performed for patients on SC. Total number of days of interruption, age, sex, T and N stage, and the use of boost were tested for the whole SC group. Analysis on the effect of timing of interruption was performed in a subgroup of 223 patients on SC who had a single unplanned interruption. Timing of interruption, either before or after the fourth week for the unplanned interruption, was tested in addition to the other variables in multivariate analysis for this subgroup of SC. Results: Twenty-seven (11.8%) patients on CC and 96 (16.9%) patients on SC had prolonged treatment. Patients on SC who had prolonged treatment had significantly poorer loco-regional control rate and disease free survival when compared with those who completed radiotherapy per schedule (p = 0.0063 and 0.001, respectively, with adjustment for stage). For CC, the effect of prolonged treatment on outcome was not significant. The small number of events for patients on CC probably account for the insignificant finding. The number of days of interruption was confirmed as prognostic factor, independent of T and N stages, for loco-regional control and disease-free survival in multivariate analysis for SC. The hazard rate for loco
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Warnier, Miriam J.; Holtkamp, Frank A.; Rutten, Frans H.; Hoes, Arno W.; de Boer, Anthonius; Mol, Peter G M; De Bruin, Marie L.
Prolongation of the QT interval can predispose to fatal ventricular arrhythmias. Differences in QT-labeling language can result in miscommunication and suboptimal risk mitigation. We systematically compared the phraseology used to communicate on QT-prolonging properties of 144 drugs newly approved
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Warnier, Miriam J.; Holtkamp, Frank A.; Rutten, Frans H.; Hoes, Arno W.; de Boer, Anthonius; Mol, Peter G. M.; De Bruin, Marie L.
Prolongation of the QT interval can predispose to fatal ventricular arrhythmias. Differences in QT-labeling language can result in miscommunication and suboptimal risk mitigation. We systematically compared the phraseology used to communicate on QT-prolonging properties of 144 drugs newly approved
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Public stigma of prolonged grief disorder : An experimental study
Eisma, Maarten C.
Prolonged grief disorder (PGD), characterized by severe, persistent and disabling grief, is being considered for inclusion in the International Classification of Diseases’ 11 (ICD-11) and a related disorder, Persistent Complex Bereavement Disorder (PCBD), is included for further investigation in the
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The Winter Procedure as Management for Prolonged Low-Flow Priapism: A Case Report
Directory of Open Access Journals (Sweden)
Hsi-Lin Hsiao
2007-10-01
Full Text Available Priapism is a prolonged penile erection that is not associated with sexual stimulation. Although the time course has not been formally defined, it is usually considered to be one that lasts for more than 4–6 hours. Low-flow (ischemic priapism is usually associated with sickle cell disease, hemoglobinopathies, neoplastic syndrome, anticoagulant therapy, psychotropic medication or idiopathic causes. Here, we report a case of prolonged low-flow priapism lasting for 2 weeks, which was successfully treated with the Winter procedure after several attempts of conservative treatment. Although the potency remains unclear and the patient needs a longer period of follow-up, the case reported here still shows that prolonged low-flow priapism can be successfully treated with the Winter procedure when conservative treatments fail.
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International Nuclear Information System (INIS)
Sols, Alberto; Ramirez-Marquez, Jose E.; Verma, Dinesh; Vitoriano, Begona
2007-01-01
Availability is one of the metrics often used in the evaluation of system effectiveness. Its use as an effectiveness metric is often dictated by the nature of the system under consideration. While some systems operate continuously, many others operate on an intermittent basis where each operational period may often involve a different set of missions. This is the most likely scenario for complex multi-functional systems, where each specific system mission may require the availability of a different combination of system elements. Similarly, for these systems, not only is it important to know whether a mission can be initiated, it is just as important to know whether the system is capable of completing such a mission. Thus, for these systems, additional measures become relevant to provide a more holistic assessment of system effectiveness. This paper presents techniques for the evaluation of both full and degraded mission reliability and mission dependability for coherent, intermittently operated multi-functional systems. These metrics complement previously developed availability and degraded availability measures of multi-functional systems, in the comprehensive assessment of system effectiveness
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National Aeronautics and Space Administration — Wireless transceivers used for NASA space missions have traditionally been highly custom and mission specific. Programs such as the GRC Space Transceiver Radio...
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The NASA X-Ray Mission Concepts Study
Petre, Robert; Ptak, A.; Bookbinder, J.; Garcia, M.; Smith, R.; Bautz, M.; Bregman, J.; Burrows, D.; Cash, W.; Jones-Forman, C.;
2012-01-01
The 2010 Astrophysics Decadal Survey recommended a significant technology development program towards realizing the scientific goals of the International X-ray Observatory (IXO). NASA has undertaken an X-ray mission concepts study to determine alternative approaches to accomplishing IXO's high ranking scientific objectives over the next decade given the budget realities, which make a flagship mission challenging to implement. The goal of the study is to determine the degree to which missions in various cost ranges from $300M to $2B could fulfill these objectives. The study process involved several steps. NASA released a Request for Information in October 2011, seeking mission concepts and enabling technology ideas from the community. The responses included a total of 14 mission concepts and 13 enabling technologies. NASA also solicited membership for and selected a Community Science Team (CST) to guide the process. A workshop was held in December 2011 in which the mission concepts and technology were presented and discussed. Based on the RFI responses and the workshop, the CST then chose a small group of notional mission concepts, representing a range of cost points, for further study. These notional missions concepts were developed through mission design laboratory activities in early 2012. The results of all these activities were captured in the final X-ray mission concepts study report, submitted to NASA in July 2012. In this presentation, we summarize the outcome of the study. We discuss background, methodology, the notional missions, and the conclusions of the study report.
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The limits of extremophilic life expanded under extraterrestrial environment-simulated experiments
Lage, C.; Dalmaso, G.; Teixeira, L.; Bendia, A.; Rosado, A.
2012-09-01
Astrobiology is a brand new area of science that seeks to understand the origin and dynamics of life in the universe. Several hypotheses to explain life in the cosmic context have been developed throughout human history, but only now technology has allowed many of them to be tested. Laboratory experiments have been able to show how chemical elements essential to life, carbon, nitrogen, oxygen and hydrogen combine in biologically important compounds. Interestingly, these compounds are found universally. As these compounds were combined to the point of originating cells and complex organisms is still a challenge to be unveiled by science. However, our 4.5 billion years-old solar system was born within a 10-billion years-old universe. Thus, simple cells like microorganisms may have had time to form in planets older than ours or other suitable molecular places in the universe. One hypothesis to explain the origin of life on Earth is called panspermia, which predicts that microbial life could have been formed in the universe billions of years ago, traveling between planets, and inseminating units of life that could have become more complex in habitable planets like ours. A project designed to test the viability of extremophile microorganisms exposed to simulated extraterrestrial environments is ongoing at the Carlos Chagas Filho Institute of Biophysics to test whether microbial life could withstand those inhospitable environments. Ultra-resistant (known or novel ones) microorganisms collected from terrestrial extreme environments, extremophiles, have been exposed to intense radiation sources simulating solar radiation (at synchrotron accelerators), capable of emitting in a few hours radiation equivalent of million years accumulated doses. The results obtained in these experiments reveal the interesting possibility of the existence of microbial life beyond Earth.
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The Importance of Contamination Knowledge in Curation - Insights into Mars Sample Return
Harrington, A. D.; Calaway, M. J.; Regberg, A. B.; Mitchell, J. L.; Fries, M. D.; Zeigler, R. A.; McCubbin, F. M.
2018-01-01
The Astromaterials Acquisition and Curation Office at NASA Johnson Space Center (JSC), in Houston, TX (henceforth Curation Office) manages the curation of extraterrestrial samples returned by NASA missions and shared collections from international partners, preserving their integrity for future scientific study while providing the samples to the international community in a fair and unbiased way. The Curation Office also curates flight and non-flight reference materials and other materials from spacecraft assembly (e.g., lubricants, paints and gases) of sample return missions that would have the potential to cross-contaminate a present or future NASA astromaterials collection.
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Science Mission Definition Studies for TROPIX
Fennell, J. F.
1997-01-01
This document summarizes the results of mission definition studies for solar electric propulsion missions that have been carried out over the last approximately three years. The major output from the studies has been two proposals which were submitted to NASA in response to Announcements of Opportunity for missions and an ongoing Global Magnetospheric Dynamics mission study. The bulk of this report consists of copies of the proposals and preliminary materials from the GMD study that will be completed in the coming months.
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Protection of Dentate Hilar Cells from Prolonged Stimulation by Intracellular Calcium Chelation
Scharfman, Helen E.; Schwartzkroin, Philip A.
1989-10-01
Prolonged afferent stimulation of the rat dentate gyrus in vivo leads to degeneration only of those cells that lack immunoreactivity for the calcium binding proteins parvalbumin and calbindin. In order to test the hypothesis that calcium binding proteins protect against the effects of prolonged stimulation, intracellular recordings were made in hippocampal slices from cells that lack immunoreactivity for calcium binding proteins. Calcium binding protein--negative cells showed electrophysiological signs of deterioration during prolonged stimulation; cells containing calcium binding protein did not. When neurons without calcium binding proteins were impaled with microelectrodes containing the calcium chelator BAPTA, and BAPTA was allowed to diffuse into the cells, these cells showed no deterioration. These results indicate that, in a complex tissue of the central nervous system, an activity-induced increase in intracellular calcium can trigger processes leading to cell deterioration, and that increasing the calcium binding capacity of a cell decreases its vulnerability to damage.
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The Asteroid Redirect Mission (ARM)
Abell, Paul; Gates, Michele; Johnson, Lindley; Chodas, Paul; Mazanek, Dan; Reeves, David; Ticker, Ronald
2016-07-01
To achieve its long-term goal of sending humans to Mars, the National Aeronautics and Space Administration (NASA) plans to proceed in a series of incrementally more complex human spaceflight missions. Today, human flight experience extends only to Low-Earth Orbit (LEO), and should problems arise during a mission, the crew can return to Earth in a matter of minutes to hours. The next logical step for human spaceflight is to gain flight experience in the vicinity of the Moon. These cis-lunar missions provide a "proving ground" for the testing of systems and operations while still accommodating an emergency return path to the Earth that would last only several days. Cis-lunar mission experience will be essential for more ambitious human missions beyond the Earth-Moon system, which will require weeks, months, or even years of transit time. In addition, NASA has been given a Grand Challenge to find all asteroid threats to human populations and know what to do about them. Obtaining knowledge of asteroid physical properties combined with performing technology demonstrations for planetary defense provide much needed information to address the issue of future asteroid impacts on Earth. Hence the combined objectives of human exploration and planetary defense give a rationale for the Asteroid Re-direct Mission (ARM). Mission Description: NASA's ARM consists of two mission segments: 1) the Asteroid Redirect Robotic Mission (ARRM), the first robotic mission to visit a large (greater than ~100 m diameter) near-Earth asteroid (NEA), collect a multi-ton boulder from its surface along with regolith samples, demonstrate a planetary defense technique, and return the asteroidal material to a stable orbit around the Moon; and 2) the Asteroid Redirect Crewed Mission (ARCM), in which astronauts will take the Orion capsule to rendezvous and dock with the robotic vehicle, conduct multiple extravehicular activities to explore the boulder, and return to Earth with samples. NASA's proposed
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IceBridge Mission Flight Reports
National Aeronautics and Space Administration — The IceBridge Mission Flight Reports data set contains flight reports from NASA Operation IceBridge Greenland, Arctic, Antarctic, and Alaska missions. Flight reports...
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Prolonged Intrauterine Retention of Foetal Bones after Midtrimester ...
African Journals Online (AJOL)
Prolonged retention of foetal bones in the uterus is a rare complication of induced abortion. We present the case of a 37 year old nullipara with retained foetal bones following a second trimester induced abortion. Accurate diagnosis and removal of the bony fragments led to restoration of fertility and subsequent delivery of a ...
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Characterizing prolonged heat effects on mortality in a sub-tropical high-density city, Hong Kong
Ho, Hung Chak; Lau, Kevin Ka-Lun; Ren, Chao; Ng, Edward
2017-11-01
Extreme hot weather events are likely to increase under future climate change, and it is exacerbated in urban areas due to the complex urban settings. It causes excess mortality due to prolonged exposure to such extreme heat. However, there is lack of universal definition of prolonged heat or heat wave, which leads to inadequacies of associated risk preparedness. Previous studies focused on estimating temperature-mortality relationship based on temperature thresholds for assessing heat-related health risks but only several studies investigated the association between types of prolonged heat and excess mortality. However, most studies focused on one or a few isolated heat waves, which cannot demonstrate typical scenarios that population has experienced. In addition, there are limited studies on the difference between daytime and nighttime temperature, resulting in insufficiency to conclude the effect of prolonged heat. In sub-tropical high-density cities where prolonged heat is common in summer, it is important to obtain a comprehensive understanding of prolonged heat for a complete assessment of heat-related health risks. In this study, six types of prolonged heat were examined by using a time-stratified analysis. We found that more consecutive hot nights contribute to higher mortality risk while the number of consecutive hot days does not have significant association with excess mortality. For a day after five consecutive hot nights, there were 7.99% [7.64%, 8.35%], 7.74% [6.93%, 8.55%], and 8.14% [7.38%, 8.88%] increases in all-cause, cardiovascular, and respiratory mortality, respectively. Non-consecutive hot days or nights are also found to contribute to short-term mortality risk. For a 7-day-period with at least five non-consecutive hot days and nights, there was 15.61% [14.52%, 16.70%] increase in all-cause mortality at lag 0-1, but only -2.00% [-2.83%, -1.17%] at lag 2-3. Differences in the temperature-mortality relationship caused by hot days and hot nights
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Mission,System Design and Payload Aspects of ESA's Mercury Cornerstone Mission
Ferri, A.; Anselmi, A.; Scoon, G. E. N.
1999-09-01
Aim of this paper is to summarise the 1-year study performed by Alenia Aerospazio in close co-operation with the European Space Agency, on the Mercury Cornerstone System and Technology Study, as a part of Horizon 2000+ Scientific Programme plan. ESA's definition study towards a mission to Mercury conceives the launch of a S/C in 2009, on a two to three years journey, plus a one-year scientific observations and data take. The mission's primary objectives are manyfolded, aiming at approaching basic scientific questions on the origin and evolution of Mercury: identify and map the chemical and mineral composition of the surface, measure the topography of surface landforms, define the gravitational field, investigate particles and magnetic fields. The mission is also intended to resolve the librational state of the planet, in a system experiment requiring high accuracy inertial attitude (arcsecond level) and orbit (m-level) reconstitution. This experiment will allow to infer whether Mercury has a molten core, which is crucial to theories of magnetic field generation, and theories of the thermal history of terrestrial type planets. A hard-lander is planned to perform in-situ surface geochemical analysis. The mission is expected to provide scientists with a global portrait of Mercury returning about 1200 Gbits of scientific data, during a 1-year observation phase. The crucial aspects of the spacecraft design have to do with the high-temperature and high-radiation environment. Thermal control is achieved by a combination of orbit selection, attitude law, and special design provisions for IR shielding and HT insulation. Ad-hoc design provisions are envisaged for power and antenna mechanisms. Though the conceptual objectives of this industrial study focused on system architectures and enabling technologies for a "Cornerstone" class mission, in this paper emphasis is given on the scientific payload aspects.
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Ganapathy, Rohan M.
This enthusiastic project describes a long-term development plan to enable human exploration of the outer solar system, with a focus on Europa and Titan. These are two of the most interesting moons of Jupiter and Saturn, respectively, because they are the places in the solar system with the greatest potential for harboring extraterrestrial life. Since human expeditions to these worlds are considered impossible with current capabilities, the proposal of a well-organized sequence of steps towards making this a reality is formulated. The project includes the necessary development strategies in key scientic and technological areas that are essential for identifying the requirements for the exploration of the outer planetary moons. Some of the topics that are analyzed throughout the project plan include: scientic observations at Europa and Titan, advanced propulsion and nuclear power systems, in-situ resource utilization, radiation mitigation techniques, closed life support systems, habitation for long-term space flight, and artificial gravity. In addition to the scientic and technological aspects of this project, it is recognized that before any research and development work may begin, some level of program management must be established. Within this paper, legal issues, national and international policy, motivation, organization and management, economic considerations, outreach, education, ethics, and social implications are all considered with respect to possible future scenarios which enable human missions to the outer solar system. This project illustrates how such accomplishments could influence a mission to Europa to search for evidence of life in its subsurface oceans. The future remains unpredictable, as does the realization of any of these possibilities. However, projects such as this remind us that the final frontier for humans is truly outer space, and only our imagination will determine where the frontier stops. We can dream of visiting other planetary
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Nationwide analysis of prolonged hospital stay and readmission after elective ventral hernia repair
DEFF Research Database (Denmark)
Helgstrand, Frederik; Rosenberg, Jacob; Kehlet, Henrik
2011-01-01
Early outcome after elective ventral hernia repair is unsatisfactory, but detailed analyses are lacking. The aim of this study was to describe the aetiology of prolonged hospital stay (LOS), readmission and death <30 days after elective ventral hernia repair.......Early outcome after elective ventral hernia repair is unsatisfactory, but detailed analyses are lacking. The aim of this study was to describe the aetiology of prolonged hospital stay (LOS), readmission and death
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DEFF Research Database (Denmark)
Staunstrup, Jørgen; Orth Gaarn-Larsen, Carsten
A mission shared by stakeholders, management and employees is a prerequisite for an engaging dialog about the many and substantial changes and challenges currently facing universities. Too often this essen-tial dialog reveals mistrust and misunderstandings about the role and outcome of the univer......A mission shared by stakeholders, management and employees is a prerequisite for an engaging dialog about the many and substantial changes and challenges currently facing universities. Too often this essen-tial dialog reveals mistrust and misunderstandings about the role and outcome...... on a shared mission aiming at value creation (in the broadest interpretation). One important aspect of choosing value as the cornerstone of the mission of universities is to stress that the outcome is measured by external stakeholders and by their standards. Most of the paper is devoted to discussing value...... it possible to lead through processes that engage and excite while creating transparency and accountability. The paper will be illustrated with examples from Denmark and the Helios initiative taken by the Danish Academy of Technical Sciences (ATV) under the headline “The value creating university – courage...
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Mission-Critical Systems Design Framework
Directory of Open Access Journals (Sweden)
Kyriakos Houliotis
2018-03-01
Full Text Available Safety-critical systems are well documented and standardized (e.g. IEC 61508, RTCA DO-178B within system design cycles. However in Defence and Security, systems that are critical to the success of a Mission are not defined within the literature nor are there any guidelines in defining criticality in their design or operational capabilities. When it comes to Vetronics (Vehicle Electronics, a mission-critical system, is a system with much complexity and mixed criticality levels that is a part of the overall platform (military vehicle offering integrated system capabilities. In this paper, a framework is presented, providing guidelines in designing efficiently and effectively mission-critical systems considering principles of Interoperable Open Architectures (IOA, mission-critical integrity levels and following new standardization activities such as NATO Generic Vehicle Architecture (NGVA. A Defensive Aid Suite (DAS system is used as a case study to illustrate how this framework can be exploited. The indention of this extension is to provide an approach to precisely estimate threats in order to de-risk missions in the very early stages.
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Approach to Spacelab Payload mission management
Craft, H. G.; Lester, R. C.
1978-01-01
The nucleus of the approach to Spacelab Payload mission management is the establishment of a single point of authority for the entire payload on a given mission. This single point mission manager will serve as a 'broker' between the individual experiments and the STS, negotiating agreements by two-part interaction. The payload mission manager, along with a small support team, will represent the users in negotiating use of STS accommodations. He will provide the support needed by each individual experimenter to meet the scientific, technological, and applications objectives of the mission with minimum cost and maximum efficiency. The investigator will assume complete responsibility for his experiment hardware definition and development and will take an active role in the integration and operation of his experiment.
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Topical Drug Formulations for Prolonged Corneal Anesthesia
Wang, Liqiang; Shankarappa, Sahadev A.; Tong, Rong; Ciolino, Joseph B.; Tsui, Jonathan H.; Chiang, Homer H.; Kohane, Daniel S.
2013-01-01
Purpose Ocular local anesthetics (OLA’s) currently used in routine clinical practice for corneal anesthesia are short acting and their ability to delay corneal healing makes them unsuitable for long-term use. In this study, we examined the effect on the duration of corneal anesthesia of the site-1 sodium channel blocker tetrodotoxin (TTX), applied with either proparacaine or the chemical permeation enhancer OTAB. The effect of test solutions on corneal healing was also studied. Methods Solutions of TTX, proparacaine, and OTAB, singly or in combination were applied topically to the rat cornea. The blink response, an indirect measure of corneal sensitivity, was recorded using a Cochet-Bonnet esthesiometer, and the duration of corneal anesthesia calculated. The effect of test compounds on the rate of corneal epithelialization was studied in vivo following corneal debridement. Results Combination of TTX and proparacaine resulted in corneal anesthesia that was 8–10 times longer in duration than that from either drug administered alone, while OTAB did not prolong anesthesia. The rate of corneal healing was moderately delayed following co-administration of TTX and proparacaine. Conclusion Co-administration of TTX and proparacaine significantly prolonged corneal anesthesia but in view of delayed corneal re-epithelialization, caution is suggested in use of the combination. PMID:23615270
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Five years of Project META - An all-sky narrow-band radio search for extraterrestrial signals
Horowitz, Paul; Sagan, Carl
1993-01-01
We have conducted a five-year search of the northern sky (delta between 30 and 60 deg) for narrow-band radio signals near the 1420 MHz line of neutral hydrogen, and its second harmonic, using an 8.4 x 10 exp 6 channel Fourier spectrometer of 0.05 Hz resolution and 400 kHz instantaneous bandwidth. The observing frequency was corrected both for motions with respect to three astronomical inertial frames, and for the effect of Earth's rotation, which provides a characteristic changing Doppler signature for narrow-band signals of extraterrestrial origin. Among the 6 x 10 exp 13 spectral channels searched, we have found 37 candidate events exceeding the average detection threshold of 1.7 x 10 exp -23 W/sq m, none of which was detected upon reobservation. The strongest of these appear to be dominated by rare processor errors. However, the strongest signals that survive culling for terrestrial interference lie in or near the Galactic plane. We describe the search and candidate events, and set limits on the prevalence of supercivilizations transmitting Doppler-precompensated beacons at H I or its second harmonic. We conclude with recommendations for future searches, based upon these findings, and a description of our next-generation search system.
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Potentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival
Fujitsuka, N; Asakawa, A; Uezono, Y; Minami, K; Yamaguchi, T; Niijima, A; Yada, T; Maejima, Y; Sedbazar, U; Sakai, T; Hattori, T; Kase, Y; Inui, A
2011-01-01
Cancer anorexia–cachexia syndrome is characterized by decreased food intake, weight loss, muscle tissue wasting and psychological distress, and this syndrome is a major source of increased morbidity and mortality in cancer patients. This study aimed to clarify the gut–brain peptides involved in the pathogenesis of the syndrome and determine effective treatment for cancer anorexia–cachexia. We show that both ghrelin insufficiency and resistance were observed in tumor-bearing rats. Corticotropin-releasing factor (CRF) decreased the plasma level of acyl ghrelin, and its receptor antagonist, α-helical CRF, increased food intake of these rats. The serotonin 2c receptor (5-HT2cR) antagonist SB242084 decreased hypothalamic CRF level and improved anorexia, gastrointestinal (GI) dysmotility and body weight loss. The ghrelin receptor antagonist (D-Lys3)-GHRP-6 worsened anorexia and hastened death in tumor-bearing rats. Ghrelin attenuated anorexia–cachexia in the short term, but failed to prolong survival, as did SB242084 administration. In addition, the herbal medicine rikkunshito improved anorexia, GI dysmotility, muscle wasting, and anxiety-related behavior and prolonged survival in animals and patients with cancer. The appetite-stimulating effect of rikkunshito was blocked by (D-Lys3)-GHRP-6. Active components of rikkunshito, hesperidin and atractylodin, potentiated ghrelin secretion and receptor signaling, respectively, and atractylodin prolonged survival in tumor-bearing rats. Our study demonstrates that the integrated mechanism underlying cancer anorexia–cachexia involves lowered ghrelin signaling due to excessive hypothalamic interactions of 5-HT with CRF through the 5-HT2cR. Potentiation of ghrelin receptor signaling may be an attractive treatment for anorexia, muscle wasting and prolong survival in patients with cancer anorexia–cachexia. PMID:22832525
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Preferences for Prolonging Life: A Prospect Theory Approach
Winter, Laraine; Lawton, M. Powell; Ruckdeschel, Katy
2003-01-01
Kahneman and Tversky's (1979) Prospect theory was tested as a model of preferences for prolonging life under various hypothetical health statuses. A sample of 384 elderly people living in congregate housing (263 healthy, 131 frail) indicated how long (if at all) they would want to live under each of nine hypothetical health conditions (e.g.,…
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Todd, N. S.; Evans, C.
2015-01-01
The Astromaterials Acquisition and Curation Office at NASA's Johnson Space Center (JSC) is the designated facility for curating all of NASA's extraterrestrial samples. The suite of collections includes the lunar samples from the Apollo missions, cosmic dust particles falling into the Earth's atmosphere, meteorites collected in Antarctica, comet and interstellar dust particles from the Stardust mission, asteroid particles from the Japanese Hayabusa mission, and solar wind atoms collected during the Genesis mission. To support planetary science research on these samples, NASA's Astromaterials Curation Office hosts the Astromaterials Curation Digital Repository, which provides descriptions of the missions and collections, and critical information about each individual sample. Our office is implementing several informatics initiatives with the goal of better serving the planetary research community. One of these initiatives aims to increase the availability and discoverability of sample data and images through the use of a newly designed common architecture for Astromaterials Curation databases.
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EU Police Mission and EU Mission for Security Sector Reform in the Democratic Republic of the Congo
DEFF Research Database (Denmark)
Højstrup Christensen, Gitte; Mandrup, Thomas
after the signing of two peace agreements (EUSEC). The EUPOL mission was terminated in 2014 and the EUSEC in 2016. Both missions were successful in some areas and failed in others. Despite their shortcomings, the EUPOL and EUSEC missions can provide valuable lessons for future EU Common Security...
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Rutt, Benjamin T; Oehlert, Mary E; Krieshok, Thomas S; Lichtenberg, James W
2018-04-01
Objective This study evaluated the effectiveness of cognitive processing therapy and prolonged exposure in conditions reflective of current clinical practice within the Veterans Health Administration. Method This study involved a retrospective review of 2030 charts. A total of 750 veterans from 10 U.S. states who received cognitive processing therapy or prolonged exposure in individual psychotherapy were included in the study (participants in cognitive processing therapy, N = 376; participants in prolonged exposure, N = 374). The main dependent variable was self-reported posttraumatic stress disorder symptoms as measured by total scores on the Posttraumatic Stress Disorder Checklist. The study used multilevel modeling to evaluate the absolute and relative effectiveness of both treatments and determine the relationship between patient-level variables and total Posttraumatic Stress Disorder Checklist scores during treatment. Results Cognitive processing therapy and prolonged exposure were equally effective at reducing total Posttraumatic Stress Disorder Checklist scores. Veterans who completed therapy reported significantly larger reductions in the Posttraumatic Stress Disorder Checklist than patients who did not complete therapy. There were no significant differences in the improvement of posttraumatic stress disorder symptoms with respect to age and three racial/ethnic groups (Caucasian, African American, and Hispanic). Conclusions Cognitive processing therapy and prolonged exposure were shown to be effective in conditions highly reflective of clinical practice and with a highly diverse sample of veterans. Challenges related to dropout from trauma focused therapy should continue to be researched.
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ACADEMIC MISSION - FROM AUTOCRACY TO BUREAUCRACY
Directory of Open Access Journals (Sweden)
LIVIU NEAMŢU
2015-12-01
Full Text Available The mission is generic expression of reason for the existence of an organization. Organizational mission ensure continuity of existence beyond the objectives and targets of activities. It is the expression of an organization's responsibilities towards the environment in which it belongs. As the organization grows and its activities or environmental conditions change, managers adapt their strategies, but stated mission will remain valid for a period of time or unchanged throughout the life of the organization. All managerial elements of the organization are aligned with stated mission, starting from the organization structure, management behavior or specific business processes. The focus of the mission of an higher education institution on a need or several integrated needs, on customers who manifest this need and on how they can be met, that really means defining of its strategic domanin, as a sphere of influence of the organization in their environment. In this sphere of influence, three components integrate on three levels of the mission: to establish needs; identify the customer type to which an organization adress and key competencies that differentiate it from the rest competitors. To that context identifies four specific forms of academic institutions starting from their mission and strategic area: autocratic academic institutions, meritocrate academic institutions, democratic academic institutions, bureaucrats academic institutions.
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Intravenous Poison Hemlock Injection Resulting in Prolonged Respiratory Failure and Encephalopathy.
Brtalik, Douglas; Stopyra, Jason; Hannum, Jennifer
2017-06-01
Poison hemlock (Conium maculatum) is a common plant with a significant toxicity. Data on this toxicity is sparse as there have been few case reports and never a documented poisoning after intravenous injection. We present a case of intravenous poison hemlock injection encountered in the emergency department. We describe a 30-year-old male who presented to the emergency department after a brief cardiac arrest after injecting poison hemlock. The patient had return of spontaneous circulation in the emergency department but had prolonged muscular weakness and encephalopathy later requiring tracheostomy. Intravenous injection of poison hemlock alkaloids can result in significant toxicity, including cardiopulmonary arrest, prolonged weakness, and encephalopathy.
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Effects of strict prolonged bed rest on cardiorespiratory fitness
DEFF Research Database (Denmark)
Ried-Larsen, Mathias; Aarts, Hugo M; Joyner, Michael J
2017-01-01
The aim of this systematic review and meta-analysis [International Prospective Register of Systematic Reviews (PROSPERO) CRD42017055619] was to assess the effects of strict prolonged bed rest (without countermeasures) on maximal oxygen uptake (V̇o2max) and to explore sources of variation therein....
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DEFF Research Database (Denmark)
Mollerup, Hannah Malthe; Gätke, M R
2011-01-01
patients undergoing electroconvulsive therapy (ECT) often receive succinylcholine as part of the anesthetic procedure. The duration of action may be prolonged in patients with genetic variants of the butyrylcholinesterase enzyme (BChE), the most common being the K- and the A-variants. The aim...... of the study was to assess the clinical significance of genetic variants in butyrylcholinesterase gene (BCHE) in patients with a suspected prolonged duration of action of succinylcholine after ECT....
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The stimulation of hematosis on short-term and prolong irradiation
International Nuclear Information System (INIS)
Tukhtaev, T.M.
1978-01-01
This book studies the stimulation of hematosis on short-term and prolong irradiation, pathogenetic mechanisms of lesion and reconstruction of hematosis at critical radiation sickness, action hematosis stimulators in short-term irradiation conditions
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Vandael, Eline; Vandenberk, Bert; Vandenberghe, Joris; Spriet, Isabel; Willems, Rik; Foulon, Veerle
2016-04-01
Many drugs, including haloperidol, are linked with a risk of QTc-prolongation, which can lead to Torsade de Pointes and sudden cardiac death. To investigate the prevalence of concomitant risk factors for QTc-prolongation in patients treated with haloperidol, and the use of safety measures to minimize this risk. University Hospitals of Leuven, Belgium. Methods A retrospective epidemiological study was performed. On 15 consecutive Mondays, all patients with a prescription for haloperidol were included. A risk score for QTc-prolongation, inspired by the pro-QTc score of Haugaa et al., was calculated based on gender, comorbidities, lab results and concomitant QTc-prolonging drugs (each factor counting for one point). Available electrocardiograms before and during the treatment of haloperidol were registered. Management of the risk of QTc-prolongation. Two hundred twenty-two patients were included (59.0 % men, median age 77 years) of whom 26.6 % had a risk score of ≥4 (known to significantly increase the mortality). Overall, 24.3 % received haloperidol in combination with other drugs with a known risk of Torsade de Pointes. Half of the patients had an electrocardiogram in the week before the start of haloperidol; only in one-third a follow-up electrocardiogram during haloperidol treatment was performed. Of the patients with a moderately (n = 41) or severely (n = 14) prolonged QTc-interval before haloperidol, 48.8 % and 42.9 % respectively had a follow-up electrocardiogram. In patients with a risk score ≥4, significantly more electrocardiograms were taken before starting haloperidol (p = 0.020). Although many patients had risk factors for QTc-prolongation (including the use of other QTc-prolonging drugs) or had a prolonged QTc on a baseline electrocardiogram, follow-up safety measures were limited. Persistent efforts should be taken to develop decision support systems to manage this risk.
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International Nuclear Information System (INIS)
2011-04-01
The IAEA's Integrated Nuclear Infrastructure Review (INIR) missions are designed to assist Member States, at their request, in evaluating the status of their national infrastructure for the introduction of a nuclear power programme. Each INIR mission is coordinated and led by the IAEA and conducted by a team of international experts drawn from Member States who have experience in different aspects of developing and deploying nuclear infrastructure. The IAEA publication Milestones in the Development of a National Infrastructure for Nuclear Power (IAEA Nuclear Energy Series No. NG-G-3.1) contains a description of 19 infrastructure issues to be considered during the different stages of development of a nuclear power programme. The starting point for an INIR mission is a self-evaluation performed by the Member State against these infrastructure issues. Following the self-evaluation, the INIR mission reviews the status of the national nuclear infrastructure, identifies existing gaps in specific infrastructure-related areas and proposes recommendations to fill these gaps. The INIR mission provides Member State representatives with an opportunity to have in depth discussions with international experts about experiences and best practices in different countries. In developing its recommendations, the INIR team takes into account the comments made by the relevant national organizations. Implementation of any of the team's recommendations is at the discretion of the Member State requesting the mission. The results of the INIR mission are expected to help the Member State to develop an action plan to fill any gaps, which in turn will help the development of the national nuclear infrastructure. The IAEA stands ready to assist, as requested and appropriate, in the different steps of this action plan. This guidance publication is directed to assist in preparing and conducting the INIR missions. It was developed under the coordination of the IAEA Integrated Nuclear Infrastructure
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Roberts, Craig; Case, Sara; Reagoso, John; Webster, Cassandra
2015-01-01
The Deep Space Climate Observatory mission launched on February 11, 2015, and inserted onto a transfer trajectory toward a Lissajous orbit around the Sun-Earth L1 libration point. This paper presents an overview of the baseline transfer orbit and early mission maneuver operations leading up to the start of nominal science orbit operations. In particular, the analysis and performance of the spacecraft insertion, mid-course correction maneuvers, and the deep-space Lissajous orbit insertion maneuvers are discussed, com-paring the baseline orbit with actual mission results and highlighting mission and operations constraints..
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National Research Council Canada - National Science Library
Symons, Steve; France, Michael; Bell, Jeffrey; Bennett, Jr, Winston
2006-01-01
... of Mission Essential Competencies (MECs). MECs are defined as the higher order individual, team, and inter-team competencies that a fully prepared pilot, crew, or flight requires for successful mission completion under adverse conditions...
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Venusians: the Planet Venus in the 18th-Century Extraterrestrial Life Debate
Duner, David
2013-05-01
In the seventeenth and eighteenth centuries it became possible to believe in the existence of life on other planets on scientific grounds. Once the Earth was no longer the center of the universe according to Copernicus, once Galileo had aimed his telescope at the Moon and found it a rough globe with mountains and seas, the assumption of life on other planets became much less far-fetched. In general there were no actual differences between Earth and Venus, since both planets orbited the Sun, were of similar size, and possessed mountains and an atmosphere. If there is life on Earth, one may ponder why it could not also exist on Venus. In the extraterrestrial life debate of the seventeenth and eighteenth centuries, the Moon, our closest celestial body, was the prime candidate for life on other worlds, although a number of scientists and scholars also speculated about life on Venus and on other planets, both within our solar system and beyond its frontiers. This chapter discusses the arguments for life on Venus and those scientific findings that were used to support them, which were based in particular on assumptions and claims that both mountains and an atmosphere had been found on Venus. The transits of Venus in the 1760s became especially important for the notion that life could thrive on Venus. Here, I detect two significant cognitive processes that were at work in the search for life on Venus, i.e., analogical reasoning and epistemic perception, while analogies and interpretations of sensory impressions based on prior knowledge played an important role in astrobiological theories.
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Improving ROLO lunar albedo model using PLEIADES-HR satellites extra-terrestrial observations
Meygret, Aimé; Blanchet, Gwendoline; Colzy, Stéphane; Gross-Colzy, Lydwine
2017-09-01
The accurate on orbit radiometric calibration of optical sensors has become a challenge for space agencies which have developed different technics involving on-board calibration systems, ground targets or extra-terrestrial targets. The combination of different approaches and targets is recommended whenever possible and necessary to reach or demonstrate a high accuracy. Among these calibration targets, the moon is widely used through the well-known ROLO (RObotic Lunar Observatory) model developed by USGS. A great and worldwide recognized work was done to characterize the moon albedo which is very stable. However the more and more demanding needs for calibration accuracy have reached the limitations of the model. This paper deals with two mains limitations: the residual error when modelling the phase angle dependency and the absolute accuracy of the model which is no more acceptable for the on orbit calibration of radiometers. Thanks to PLEIADES high resolution satellites agility, a significant data base of moon and stars images was acquired, allowing to show the limitations of ROLO model and to characterize the errors. The phase angle residual dependency is modelled using PLEIADES 1B images acquired for different quasi-complete moon cycles with a phase angle varying by less than 1°. The absolute albedo residual error is modelled using PLEIADES 1A images taken over stars and the moon. The accurate knowledge of the stars spectral irradiance is transferred to the moon spectral albedo using the satellite as a transfer radiometer. This paper describes the data set used, the ROLO model residual errors and their modelling, the quality of the proposed correction and show some calibration results using this improved model.
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Evaluation of Superconducting Magnet Shield Configurations for Long Duration Manned Space Missions.
Ambroglini, Filippo; Battiston, Roberto; Burger, William J
2016-01-01
A manned mission to Mars would present an important long-term health risk to the crew members due to the prolonged exposure to the ionizing radiation of galactic cosmic-rays. The radiation levels would largely exceed those encountered in the Apollo missions. An increase in the passive shielding provided by the spacecraft implies a significant increase of the mass. The advent of superconducting magnets in the early 1960s was considered an attractive alternative. The technology allows to generate magnetic fields capable to deflect the cosmic-rays in a manner analogous to the reduction of the particle fluxes in the upper atmosphere due to the Earth's dipole magnetic field. A series of the three studies have been conducted over the last 5 years, funded successively by European Space Agency (ESA), the NASA Innovative Advanced Concepts (NIAC) program, and the Union European's Seventh Framework Programme (FP7). The shielding configurations studied are based on high-temperature superconductors, which eliminate the need to operate with liquid helium. The mass estimates of the coils and supporting structure of the engineering designs are based on the current and expected near-future performance of the superconducting materials. In each case, the shield performance, in terms of dose reduction, is provided by a 3-dimensional Monte Carlo simulation, which treats in detail the electromagnetic and hadronic interactions of the galactic-cosmic rays, and the secondary particles they produce in the materials of the shield and spacecraft. A summary of the results of the studies, representing one of the most detailed and comprehensive efforts made in the field, is presented.
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Social Tagging of Mission Data
Norris, Jeffrey S.; Wallick, Michael N.; Joswig, Joseph C.; Powell, Mark W.; Torres, Recaredo J.; Mittman, David S.; Abramyan, Lucy; Crockett, Thomas M.; Shams, Khawaja S.; Fox, Jason M.;
2010-01-01
Mars missions will generate a large amount of data in various forms, such as daily plans, images, and scientific information. Often, there is a semantic linkage between images that cannot be captured automatically. Software is needed that will provide a method for creating arbitrary tags for this mission data so that items with a similar tag can be related to each other. The tags should be visible and searchable for all users. A new routine was written to offer a new and more flexible search option over previous applications. This software allows users of the MSLICE program to apply any number of arbitrary tags to a piece of mission data through a MSLICE search interface. The application of tags creates relationships between data that did not previously exist. These tags can be easily removed and changed, and contain enough flexibility to be specifically configured for any mission. This gives users the ability to quickly recall or draw attention to particular pieces of mission data, for example: Give a semantic and meaningful description to mission data; for example, tag all images with a rock in them with the tag "rock." Rapidly recall specific and useful pieces of data; for example, tag a plan as"driving template." Call specific data to a user s attention; for example, tag a plan as "for:User." This software is part of the MSLICE release, which was written in Java. It will run on any current Windows, Macintosh, or Linux system.
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Prolonged Delayed Graft Function Is Associated with Inferior Patient and Kidney Allograft Survivals.
Directory of Open Access Journals (Sweden)
Tainá Veras de Sandes-Freitas
Full Text Available It is unclear if there is an association between the duration of delayed graft function (DGF and kidney transplant (KT outcomes. This study investigated the impact of prolonged DGF on patient and graft survivals, and renal function one year after KT. This single center retrospective analysis included all deceased donor KT performed between Jan/1998 and Dec/2008 (n = 1412. Patients were grouped in quartiles according to duration of DGF (1-5, 6-10, 11-15, and >15 days, designated as prolonged DGF. The overall incidence of DGF was 54.2%. Prolonged DGF was associated with retransplantation (OR 2.110, CI95% 1.064-4.184,p = 0.033 and more than 3 HLA mismatches (OR 1.819, CI95% 1.117-2.962,p = 0.016. The incidence of acute rejection was higher in patients with DGF compared with those without DGF (36.2% vs. 12.2%, p<0.001. Compared to patients without DGF, DGF(1-5, DGF(6-10, and DGF(11-15, patients with prolonged DGF showed inferior one year patient survival (95.2% vs. 95.4% vs. 95.5% vs. 93.4% vs. 88.86%, p = 0.003, graft survival (91% vs. 91.4% vs. 92% vs. 88.7% vs. 70.5%, p<0.001, death-censored graft survival (95.7% vs. 95.4% vs. 96.4% vs. 94% vs. 79.3%, p<0.001, and creatinine clearance (58.0±24.6 vs. 55.8±22.2 vs. 53.8±24.1 vs. 53.0±27.2 vs. 36.8±27.0 mL/min, p<0.001, respectively. Multivariable analysis showed that prolonged DGF was an independent risk factor for graft loss (OR 3.876, CI95% 2.270-6.618, p<0.001, death censored graft loss (OR 4.103, CI95% 2.055-8.193, p<0.001, and death (OR 3.065, CI95% 1.536-6.117, p = 0.001. Prolonged DGF, determined by retransplantation and higher HLA mismatches, was associated with inferior renal function, and patient and graft survivals at one year.
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ERYTHEMA NODOSUM AND PROLONGED FEVER ASSOCIATED TO SECONDARY HYPERPARATHYROIDISM
Directory of Open Access Journals (Sweden)
Galimberti R
2005-08-01
Full Text Available SUMMARYSecondary hyperparathyroidism is one of the main deragements caused by chronic renal failure, and parathyroid hormone is considered one of the toxins of the uremic syndrome. Prolonged fever due to primary hyperparathyroidism have already been described in the literature but not yet as induced by secondary hyperparathyroidism. In this case report a patient suffering from an erythema nodosum and prolonged fever associated to secondary hyperparathyroidism that disappeared through subtotal parathyroidectomy is presented.RESUMENEl hiperparatiroidismo secundario es uno de los principales disturbios causados por la insuficiencia renal crónica, y la paratohormona es considerada una de las toxinas del sindrome urémico. El sindrome febril prolongado secundario a hiperparatiroidismo primario ya ha sido descripto en la literatura, aunque no lo ha sido aun el inducido por hiperparatiroidismo secundario. En el presente reporte se presenta un caso de eritema nodoso y sindrome febril prolongado asociado a hiperparatiroidismo secundario y que resolvió luego de efectuada una paratiroidectomía subtotal.
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SPICE for ESA Planetary Missions
Costa, M.
2018-04-01
The ESA SPICE Service leads the SPICE operations for ESA missions and is responsible for the generation of the SPICE Kernel Dataset for ESA missions. This contribution will describe the status of these datasets and outline the future developments.
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Parametric cost estimation for space science missions
Lillie, Charles F.; Thompson, Bruce E.
2008-07-01
Cost estimation for space science missions is critically important in budgeting for successful missions. The process requires consideration of a number of parameters, where many of the values are only known to a limited accuracy. The results of cost estimation are not perfect, but must be calculated and compared with the estimates that the government uses for budgeting purposes. Uncertainties in the input parameters result from evolving requirements for missions that are typically the "first of a kind" with "state-of-the-art" instruments and new spacecraft and payload technologies that make it difficult to base estimates on the cost histories of previous missions. Even the cost of heritage avionics is uncertain due to parts obsolescence and the resulting redesign work. Through experience and use of industry best practices developed in participation with the Aerospace Industries Association (AIA), Northrop Grumman has developed a parametric modeling approach that can provide a reasonably accurate cost range and most probable cost for future space missions. During the initial mission phases, the approach uses mass- and powerbased cost estimating relationships (CER)'s developed with historical data from previous missions. In later mission phases, when the mission requirements are better defined, these estimates are updated with vendor's bids and "bottoms- up", "grass-roots" material and labor cost estimates based on detailed schedules and assigned tasks. In this paper we describe how we develop our CER's for parametric cost estimation and how they can be applied to estimate the costs for future space science missions like those presented to the Astronomy & Astrophysics Decadal Survey Study Committees.
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The deep space 1 extended mission
Rayman, Marc D.; Varghese, Philip
2001-03-01
The primary mission of Deep Space 1 (DS1), the first flight of the New Millennium program, completed successfully in September 1999, having exceeded its objectives of testing new, high-risk technologies important for future space and Earth science missions. DS1 is now in its extended mission, with plans to take advantage of the advanced technologies, including solar electric propulsion, to conduct an encounter with comet 19P/Borrelly in September 2001. During the extended mission, the spacecraft's commercial star tracker failed; this critical loss prevented the spacecraft from achieving three-axis attitude control or knowledge. A two-phase approach to recovering the mission was undertaken. The first involved devising a new method of pointing the high-gain antenna to Earth using the radio signal received at the Deep Space Network as an indicator of spacecraft attitude. The second was the development of new flight software that allowed the spacecraft to return to three-axis operation without substantial ground assistance. The principal new feature of this software is the use of the science camera as an attitude sensor. The differences between the science camera and the star tracker have important implications not only for the design of the new software but also for the methods of operating the spacecraft and conducting the mission. The ambitious rescue was fully successful, and the extended mission is back on track.
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Massively Clustered CubeSats NCPS Demo Mission
Robertson, Glen A.; Young, David; Kim, Tony; Houts, Mike
2013-01-01
Technologies under development for the proposed Nuclear Cryogenic Propulsion Stage (NCPS) will require an un-crewed demonstration mission before they can be flight qualified over distances and time frames representative of a crewed Mars mission. In this paper, we describe a Massively Clustered CubeSats platform, possibly comprising hundreds of CubeSats, as the main payload of the NCPS demo mission. This platform would enable a mechanism for cost savings for the demo mission through shared support between NASA and other government agencies as well as leveraged commercial aerospace and academic community involvement. We believe a Massively Clustered CubeSats platform should be an obvious first choice for the NCPS demo mission when one considers that cost and risk of the payload can be spread across many CubeSat customers and that the NCPS demo mission can capitalize on using CubeSats developed by others for its own instrumentation needs. Moreover, a demo mission of the NCPS offers an unprecedented opportunity to invigorate the public on a global scale through direct individual participation coordinated through a web-based collaboration engine. The platform we describe would be capable of delivering CubeSats at various locations along a trajectory toward the primary mission destination, in this case Mars, permitting a variety of potential CubeSat-specific missions. Cameras on various CubeSats can also be used to provide multiple views of the space environment and the NCPS vehicle for video monitoring as well as allow the public to "ride along" as virtual passengers on the mission. This collaborative approach could even initiate a brand new Science, Technology, Engineering and Math (STEM) program for launching student developed CubeSat payloads beyond Low Earth Orbit (LEO) on future deep space technology qualification missions. Keywords: Nuclear Propulsion, NCPS, SLS, Mars, CubeSat.
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Keller, Guillermo A; Alvarez, Paulino A; Ponte, Marcelo L; Belloso, Waldo H; Bagnes, Claudia; Sparanochia, Cecilia; Gonzalez, Claudio D; Villa Etchegoyen, M Cecilia; Diez, Roberto A; Di Girolamo, Guillermo
2016-01-01
The actual prevalence of drug induced QTc prolongation in clinical practice is unknown. Our objective was to determine the occurrence and characteristics of drug-induced QT prolongation in several common clinical practices. Additionally, a subgroup of patients treated with dextropropoxyphene of particular interest for the regulatory authority was analysed. Medical history and comorbidities predisposing to QT interval prolongation were registered for 1270 patient requiring medical assistance that involved drug administration. Three ionograms and ECGs were performed: baseline, intra- and after treatment; QT interval was corrected with Bazzet formula. Among patients, 9.9% presented QTc >450/470 ms, 3% QTc > 500 ms, 12.7% ΔQTc >30 ms and 5.2% ΔQTc >60 ms. QTc prolongation associated with congestive heart failure, ischemic cardiopathy, diabetes, renal failure, arrhythmias, hypothyroidism, and bradycardia. At univariate analysis, clarithromycin, haloperidol, tramadol, amiodarone, glyceryl trinitrate, amoxicillin + clavulanic acid, amoxicillin + sulbactam, ampicillin + sulbactam, fentanyl, piperacillin + tazobactam, and diazepam prolonged QTc. Prolongation remained significantly associated with furosemide, clarithromycin, glyceryl trinitrate and betalactamase inhibitors after multivariate analysis. QT interval prolongation in everyday practice is frequent, in association to clinical factors and drugs that can be easily identified for monitoring and prevention strategies.
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Energy Technology Data Exchange (ETDEWEB)
NONE
2001-07-01
This preliminary report analyses the desirable evolutions of gas transport tariffing and examines some questions relative to the opening of competition on the French gas market. The report is made of two documents: a synthesis of the previous report with some recommendations about the tariffing of gas transport, about the modalities of network access to third parties, and about the dissociation between transport and trade book-keeping activities. The second document is the progress report about the opening of the French gas market. The first part presents the European problem of competition in the gas supply and its consequences on the opening and operation of the French gas market. The second part presents some partial syntheses about each topic of the mission letter of the Ministry of Economics, Finances and Industry: future evolution of network access tariffs, critical analysis of contractual documents for gas transport and delivery, examination of auxiliary services linked with the access to the network (modulation, balancing, conversion), consideration about the processing of network congestions and denied accesses, analysis of the metering dissociation between the integrated activities of gas operators. Some documents are attached in appendixes: the mission letter from July 9, 2001, the detailed analysis of the new temporary tariffs of GdF and CFM, the offer of methane terminals access to third parties, the compatibility of a nodal tariffing with the presence of three transport operators (GdF, CFM and GSO), the contract-type for GdF supply, and the contract-type for GdF connection. (J.S.)
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Mission Reliability Estimation for Repairable Robot Teams
Trebi-Ollennu, Ashitey; Dolan, John; Stancliff, Stephen
2010-01-01
A mission reliability estimation method has been designed to translate mission requirements into choices of robot modules in order to configure a multi-robot team to have high reliability at minimal cost. In order to build cost-effective robot teams for long-term missions, one must be able to compare alternative design paradigms in a principled way by comparing the reliability of different robot models and robot team configurations. Core modules have been created including: a probabilistic module with reliability-cost characteristics, a method for combining the characteristics of multiple modules to determine an overall reliability-cost characteristic, and a method for the generation of legitimate module combinations based on mission specifications and the selection of the best of the resulting combinations from a cost-reliability standpoint. The developed methodology can be used to predict the probability of a mission being completed, given information about the components used to build the robots, as well as information about the mission tasks. In the research for this innovation, sample robot missions were examined and compared to the performance of robot teams with different numbers of robots and different numbers of spare components. Data that a mission designer would need was factored in, such as whether it would be better to have a spare robot versus an equivalent number of spare parts, or if mission cost can be reduced while maintaining reliability using spares. This analytical model was applied to an example robot mission, examining the cost-reliability tradeoffs among different team configurations. Particularly scrutinized were teams using either redundancy (spare robots) or repairability (spare components). Using conservative estimates of the cost-reliability relationship, results show that it is possible to significantly reduce the cost of a robotic mission by using cheaper, lower-reliability components and providing spares. This suggests that the
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The impact of prolonged violent video-gaming on adolescent sleep: an experimental study.
King, Daniel L; Gradisar, Michael; Drummond, Aaron; Lovato, Nicole; Wessel, Jason; Micic, Gorica; Douglas, Paul; Delfabbro, Paul
2013-04-01
Video-gaming is an increasingly prevalent activity among children and adolescents that is known to influence several areas of emotional, cognitive and behavioural functioning. Currently there is insufficient experimental evidence about how extended video-game play may affect adolescents' sleep. The aim of this study was to investigate the short-term impact of adolescents' prolonged exposure to violent video-gaming on sleep. Seventeen male adolescents (mean age = 16 ± 1 years) with no current sleep difficulties played a novel, fast-paced, violent video-game (50 or 150 min) before their usual bedtime on two different testing nights in a sleep laboratory. Objective (polysomnography-measured sleep and heart rate) and subjective (single-night sleep diary) measures were obtained to assess the arousing effects of prolonged gaming. Compared with regular gaming, prolonged gaming produced decreases in objective sleep efficiency (by 7 ± 2%, falling below 85%) and total sleep time (by 27 ± 12 min) that was contributed by a near-moderate reduction in rapid eye movement sleep (Cohen's d = 0.48). Subjective sleep-onset latency significantly increased by 17 ± 8 min, and there was a moderate reduction in self-reported sleep quality after prolonged gaming (Cohen's d = 0.53). Heart rate did not differ significantly between video-gaming conditions during pre-sleep game-play or the sleep-onset phase. Results provide evidence that prolonged video-gaming may cause clinically significant disruption to adolescent sleep, even when sleep after video-gaming is initiated at normal bedtime. However, physiological arousal may not necessarily be the mechanism by which technology use affects sleep. © 2012 European Sleep Research Society.
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[Prolonged desensitization pretreatment for in vitro fertilization in women with polycystic ovary].
Kuczyński, W; Czech, R; Redźko, S; Wasilewski, T; Mrugacz, G; Wołczyński, S; Pietrewicz, P; Grochowski, D; Szamatowicz, M
2000-09-01
To analyse the outcome of intracytoplasmic sperm injection (ICSI) in women with severe polycystic ovary disease (PCD), stimulated after prolonged pituitary desensitization in comparison with regular long protocol therapy. The results of controlled ovarian hyperstimulation (COH), fertilization rate, early embryo development parameters and clinical pregnancy rates were compared depending on the duration of pituitary desensitization before gonadotropin administration. A total of 60 patients with severe PCOD were desensitized with GnRH agonist up to 30 days before COH. The results were compared with the group of 213 patients with mild PCOD treated with regular long protocol (control). We observed a slightly higher rate of mature oocytes MII as well as the number of embryos obtained in the control group, however the pregnancy rate in the group with prolonged desensitization was significantly higher (50%) in comparison to the control group (33.8%). The prolonged pituitary desensitization before controlled ovarian hyperstimulation gives better chance for obtaining pregnancy in patients with severe PCOD. It could be recommended facing previous treatment failure.
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Siriwardhana, Chesmal; Stewart, Robert
2013-03-01
Forced internal displacement has been rising steadily, mainly due to conflict. Many internally displaced people (IDP) experience prolonged displacement. Global research evidence suggests that many of these IDP are at high risk for developing mental disorders, adding weight to the global burden of disease. However, individual and community resilience may act as protective factors. Return migration may be an option for some IDP populations, especially when conflicts end, although return migration may itself be associated with worse mental health. Limited evidence is available on effects of resettlement or return migration following prolonged forced internal displacement on mental health. Also, the role of resilience factors remains to be clarified following situations of prolonged displacement. The public health impact of internal displacement is not clearly understood. Epidemiological and interventional research in IDP mental health needs to look beyond medicalised models and encompass broader social and cultural aspects. The resilience factor should be integrated and explored more in mental health research among IDP and a clearly focused multidisciplinary approach is advocated.
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Trajectory Design Considerations for Exploration Mission 1
Dawn, Timothy F.; Gutkowski, Jeffrey P.; Batcha, Amelia L.; Williams, Jacob; Pedrotty, Samuel M.
2018-01-01
Exploration Mission 1 (EM-1) will be the first mission to send an uncrewed Orion Multi-Purpose Crew Vehicle (MPCV) to cislunar space in the fall of 2019. EM-1 was originally conceived as a lunar free-return mission, but was later changed to a Distant Retrograde Orbit (DRO) mission as a precursor to the Asteroid Redirect Mission. To understand the required mission performance (i.e., propellant requirement), a series of trajectory optimization runs was conducted using JSC's Copernicus spacecraft trajectory optimization tool. In order for the runs to be done in a timely manner, it was necessary to employ a parallelization approach on a computing cluster using a new trajectory scan tool written in Python. Details of the scan tool are provided and how it is used to perform the scans and post-process the results. Initially, a scan of daily due east launched EM-1 DRO missions in 2018 was made. Valid mission opportunities are ones that do not exceed the useable propellant available to perform the required burns. The initial scan data showed the propellant and delta-V performance patterns for each launch period. As questions were raised from different subsystems (e.g., power, thermal, communications, flight operations, etc.), the mission parameters or data that were of interest to them were added to the scan output data file. The additional data includes: (1) local launch and landing times in relation to sunrise and sunset, (2) length of eclipse periods during the in-space portion of the mission, (3) Earth line of sight from cislunar space, (4) Deep Space Network field of view looking towards cislunar space, and (5) variation of the downrange distance from Earth entry interface to splashdown. Mission design trades can also be performed based on the information that the additional data shows. For example, if the landing is in darkness, but the recovery operations team desires a landing in daylight, then an analysis is performed to determine how to change the mission design
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Litomisky, Krystof
2012-01-01
Even though NASA's space missions are many and varied, there are some tasks that are common to all of them. For example, all spacecraft need to communicate with other entities, and all spacecraft need to know where they are. These tasks use tools and services that can be inherited and reused between missions, reducing systems engineering effort and therefore reducing cost.The Advanced Multi-Mission Operations System, or AMMOS, is a collection of multimission tools and services, whose development and maintenance are funded by NASA. I created HierarchThis, a plugin designed to provide an interactive interface to help customers identify mission-relevant tools and services. HierarchThis automatically creates diagrams of the AMMOS database, and then allows users to show/hide specific details through a graphical interface. Once customers identify tools and services they want for a specific mission, HierarchThis can automatically generate a contract between the Multimission Ground Systems and Services Office, which manages AMMOS, and the customer. The document contains the selected AMMOS components, along with their capabilities and satisfied requirements. HierarchThis reduces the time needed for the process from service selections to having a mission-specific contract from the order of days to the order of minutes.
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Directory of Open Access Journals (Sweden)
Liu
2005-11-01
Full Text Available The Double Star Programme (DSP was first proposed by China in March, 1997 at the Fragrant Hill Workshop on Space Science, Beijing, organized by the Chinese Academy of Science. It is the first mission in collaboration between China and ESA. The mission is made of two spacecraft to investigate the magnetospheric global processes and their response to the interplanetary disturbances in conjunction with the Cluster mission. The first spacecraft, TC-1 (Tan Ce means "Explorer", was launched on 29 December 2003, and the second one, TC-2, on 25 July 2004 on board two Chinese Long March 2C rockets. TC-1 was injected in an equatorial orbit of 570x79000 km altitude with a 28° inclination and TC-2 in a polar orbit of 560x38000 km altitude. The orbits have been designed to complement the Cluster mission by maximizing the time when both Cluster and Double Star are in the same scientific regions. The two missions allow simultaneous observations of the Earth magnetosphere from six points in space. To facilitate the comparison of data, half of the Double Star payload is made of spare or duplicates of the Cluster instruments; the other half is made of Chinese instruments. The science operations are coordinated by the Chinese DSP Scientific Operations Centre (DSOC in Beijing and the European Payload Operations Service (EPOS at RAL, UK. The spacecraft and ground segment operations are performed by the DSP Operations and Management Centre (DOMC and DSOC in China, using three ground station, in Beijing, Shanghai and Villafranca.
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Prolonged fasting increases purine recycling in post-weaned northern elephant seals.
Soñanez-Organis, José Guadalupe; Vázquez-Medina, José Pablo; Zenteno-Savín, Tania; Aguilar, Andres; Crocker, Daniel E; Ortiz, Rudy M
2012-05-01
Northern elephant seals are naturally adapted to prolonged periods (1-2 months) of absolute food and water deprivation (fasting). In terrestrial mammals, food deprivation stimulates ATP degradation and decreases ATP synthesis, resulting in the accumulation of purines (ATP degradation byproducts). Hypoxanthine-guanine phosphoribosyl transferase (HGPRT) salvages ATP by recycling the purine degradation products derived from xanthine oxidase (XO) metabolism, which also promotes oxidant production. The contributions of HGPRT to purine recycling during prolonged food deprivation in marine mammals are not well defined. In the present study we cloned and characterized the complete and partial cDNA sequences that encode for HGPRT and xanthine oxidoreductase (XOR) in northern elephant seals. We also measured XO protein expression and circulating activity, along with xanthine and hypoxanthine plasma content in fasting northern elephant seal pups. Blood, adipose and muscle tissue samples were collected from animals after 1, 3, 5 and 7 weeks of their natural post-weaning fast. The complete HGPRT and partial XOR cDNA sequences are 771 and 345 bp long and encode proteins of 218 and 115 amino acids, respectively, with conserved domains important for their function and regulation. XOR mRNA and XO protein expression increased 3-fold and 1.7-fold with fasting, respectively, whereas HGPRT mRNA (4-fold) and protein (2-fold) expression increased after 7 weeks in adipose tissue and muscle. Plasma xanthine (3-fold) and hypoxanthine (2.5-fold) levels, and XO (1.7- to 20-fold) and HGPRT (1.5- to 1.7-fold) activities increased during the last 2 weeks of fasting. Results suggest that prolonged fasting in elephant seal pups is associated with increased capacity to recycle purines, which may contribute to ameliorating oxidant production and enhancing the supply of ATP, both of which would be beneficial during prolonged food deprivation and appear to be adaptive in this species.
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Directory of Open Access Journals (Sweden)
Chen-Joe Fong
2009-01-01
Full Text Available The FORMOSAT-3/COSMIC spacecraft constellation consisting of six LEO satellites is the world's first operational GPS Radio Occultation (RO mission. The mission is jointly developed by Taiwan¡¦s National Space Organization (NSPO and the United States¡¦UCAR in collaboration with NSF, USAF, NOAA, NASA, NASA's Jet Propulsion Laboratory, and the US Naval Research Laboratory. The FORMOSAT-3/COSMIC satellites were successfully launched from Vandenberg US AFB in California at 0140 UTC 15 April 2006 into the same orbit plane of the designated 516 km altitude. The mission goal is to deploy the six satellites into six orbit planes at 800 km altitude with a 30-degree separation for evenly distributed global coverage. All six FORMOSAT-3/COSMIC satellites are currently maintaining a satisfactory good state-of-health. Five out of six satellites have reached their final mission orbit of 800 km as of November 2007. The data as received by FORMOSAT-3/COSMIC satellites constellation have been processed in near real time into 2500 good ionospheric profiles and 1800 good atmospheric profiles per day. These have outnumbered the worldwide radiosondes (~900 mostly over land launched from the ground per day. The processed atmospheric RO data have been assimilated into the Numerical Weather Prediction (NWP models for real-time weather prediction and typhoon/hurricane forecasting by many major weather centers in the world. This paper describes the FORMOSAT-3/COSMIC satellite constellation system performance and the mission results that span the period from April 2006 to October 2007; and reviews the prospect of a future follow-on mission.
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2010-07-27
... and Dhahran; and Networking receptions in two cities of the trade mission. Proposed Mission Timetable... Saudi Arabia: Third City Stop Added to the Trade Mission Itinerary AGENCY: International Trade... expansion at Jubail Industrial City II with around 20 petrochemical and infrastructure projects worth more...
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INTEGRITY -- Integrated Human Exploration Mission Simulation Facility
Henninger, D.; Tri, T.; Daues, K.
It is proposed to develop a high -fidelity ground facil ity to carry out long-duration human exploration mission simulations. These would not be merely computer simulations - they would in fact comprise a series of actual missions that just happen to stay on earth. These missions would include all elements of an actual mission, using actual technologies that would be used for the real mission. These missions would also include such elements as extravehicular activities, robotic systems, telepresence and teleoperation, surface drilling technology--all using a simulated planetary landscape. A sequence of missions would be defined that get progressively longer and more robust, perhaps a series of five or six missions over a span of 10 to 15 years ranging in durat ion from 180 days up to 1000 days. This high-fidelity ground facility would operate hand-in-hand with a host of other terrestrial analog sites such as the Antarctic, Haughton Crater, and the Arizona desert. Of course, all of these analog mission simulations will be conducted here on earth in 1-g, and NASA will still need the Shuttle and ISS to carry out all the microgravity and hypogravity science experiments and technology validations. The proposed missions would have sufficient definition such that definitive requirements could be derived from them to serve as direction for all the program elements of the mission. Additionally, specific milestones would be established for the "launch" date of each mission so that R&D programs would have both good requirements and solid milestones from which to build their implementation plans. Mission aspects that could not be directly incorporated into the ground facility would be simulated via software. New management techniques would be developed for evaluation in this ground test facility program. These new techniques would have embedded metrics which would allow them to be continuously evaluated and adjusted so that by the time the sequence of missions is completed
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Brumbaugh, Jane E; Colaizy, Tarah T; Nuangchamnong, Nina; O'Brien, Emily A; Fleener, Diedre K; Rijhsinghani, Asha; Klein, Jonathan M
2014-11-01
To evaluate neonatal survival after prolonged preterm premature rupture of membranes (PROM) in the era of antenatal corticosteroids, surfactant, and inhaled nitric oxide. A single-center retrospective cohort study of neonates born from 2002-2011 after prolonged (1 week or more) preterm (less than 24 weeks of gestation) rupture of membranes was performed. The primary outcome was survival to discharge. Neonates whose membranes ruptured less than 24 hours before delivery (n=116) were matched (2:1) on gestational age at birth, sex, and antenatal corticosteroid exposure with neonates whose membranes ruptured 1 week or more before delivery (n=58). Analysis used conditional logistic regression for categorical data and Wilcoxon signed rank test for continuous data. The prolonged preterm PROM exposed and unexposed cohorts had survival rates of 90% and 95%, respectively, although underpowered to assess the statistical significance (P=.313). Exposed neonates were more likely have pulmonary hypoplasia (26/58 exposed, 1/114 unexposed, Prupture (20.4 weeks exposed, 22.3 weeks unexposed, P=.189), length of rupture (3.7 weeks exposed, 6.4 weeks unexposed, P=.717), and lowest maximal vertical pocket before 24 weeks of gestation (0 cm exposed, 1.4 cm unexposed, P=.114) did not discriminate between survivors and nonsurvivors after exposure to prolonged preterm PROM. With antenatal steroid exposure and aggressive pulmonary management, survival to discharge after prolonged preterm PROM was 90%. Pulmonary morbidities were common. Of note, the data were limited to women who remained pregnant 1 week or longer after rupture of membranes.
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Prolonged use of indwelling urinary catheter following acute urinary ...
African Journals Online (AJOL)
J.O. Bello
prolonged use of urinary catheters following acute urinary retention secondary to benign prostate enlarge- ment (BPE) and urethral ... indwelling urinary catheter for >3 months following acute urinary retention due to BPE or USD. The study .... the major health-care financing strategy in Nigeria and accounts for more than ...
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Tyler, G. L.
1972-01-01
Scientific instrumentation for satellite communication and radio tracking systems in the outer planet exploration mission is discussed. Mission planning considers observations of planetary and satellite-masses, -atmospheres, -magnetic fields, -surfaces, -gravitational fields, solar wind composition, planetary radio emissions, and tests of general relativity in time delay and ray bending experiments.
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SU119. Internalized Stigma in Adults With Early-Phase vs Prolonged Psychosis
Firmin, Ruth; Vohs, Jenifer; Luther, Lauren; Yanos, Philip; Leonhardt, Bethany; Lysaker, Paul
2017-01-01
Abstract Background: While internalized stigma is associated with negative outcomes among those with prolonged psychosis, surprisingly little work has focused on when in the course of one’s illness stigma is internalized and the impact of internalization on symptoms or quality of life over the course of the illness. Therefore, this study investigated whether (1) internalized stigma is greater among those later in the course of psychosis and (2) whether internalized stigma has a stronger negative relationship with quality of life or symptoms among those with prolonged compared to early-phase psychosis. Methods: Individuals with early-phase (n = 40) and prolonged psychosis (n = 71) who were receiving outpatient services at an early-intervention clinic and a VA medical center, respectively, completed self-report measures of internalized stigma and interview-rated measures of symptoms and quality of life. Results: Controlling for education, race, and sex differences, internalized stigma was significantly greater among those with prolonged compared to early-phase psychosis. Internalized stigma was negatively related to quality of life and positively related to symptoms in both groups. Furthermore, the magnitude of the relationship between cognitive symptoms and internalized stigma was significantly greater among those with early-phase psychosis. Stereotype endorsement, discrimination experiences, and social withdrawal also deferentially related to symptoms and quality of life across the 2 samples. Conclusion: Findings suggest that internalized stigma is an important variable to incorporate into models of early psychosis. Further, internalized stigma may be a possible treatment target among those in their early phase of psychosis.
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Paternal work stress and prolonged time to pregnancy.
Lee, Mi-Sun; Paek, Domyung; Eum, Ki-Do; Siegrist, Johannes; Li, Jian; Lee, Hye-Eun; Cho, Sung-Il
2009-01-01
The aim of this study was to explore an association between psychosocial stress at work in married men and their spouses' prolonged time to pregnancy (TTP). All married male workers of a large Korean petrochemical enterprise and their wives fulfilling the selection criteria were included. Main selection criteria were lack of use of contraceptives and experienced pregnancy in recent past. Data were available from 322 couples. Psychosocial stress at work was measured by the effort-reward imbalance questionnaire. Prolonged TTP was measured by the "TTP questionnaire". After adjustment for confounding effects of demographic and life-style characteristics and benzene exposure, delayed TTP, defined by frequency of first-cycle pregnancy, was associated with one standard deviation (SD) increase of the effort-reward ratio in the chronically stressed group of married men (OR = 0.47; 95% CI = 0.22-0.99) in logistic regression analysis. A similar, but somewhat weaker effect, was found for the overall group (OR = 0.67; 95% CI = 0.47-0.94). Paternal stress at work, as measured by effort-reward imbalance, seemed to be associated with a decreased number of conceptions in the first menstrual cycle.
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AVS-1357 inhibits melanogenesis via prolonged ERK activation.
Kim, Dong-Seok; Lee, Hyun-Kyung; Park, Seo-Hyoung; Chae, Chong Hak; Park, Kyoung-Chan
2009-08-01
In this study, we demonstrated that a derivative of imidazole, AVS-1357, is a novel skin-whitening compound. AVS-1357 was found to significantly inhibit melanin production in a dose-dependent manner; however, it did not directly inhibit tyrosinase. Furthermore, we found that AVS-1357 induced prolonged activation of extracellular signal-regulated kinase (ERK) and Akt, while it downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase. It has been reported that the activation of ERK and/or Akt is involved in melanogenesis. Therefore, we examined the effects of AVS-1357 on melanogenesis in the absence or presence of PD98059 (a specific inhibitor of the ERK pathway) and/or LY294002 (a specific inhibitor of the Akt pathway). PD98059 dramatically increased melanogenesis, whereas LY294002 had no effect. Furthermore, PD98059 attenuated AVS-1357 induced ERK activation, as well as the downregulation of MITF and tyrosinase. These findings suggest that the effects of AVS-1357 occur via downregulation of MITF and tyrosinase, which is caused by AVS-1357-induced prolonged ERK activation. Taken together, our results indicate that AVS-1357 has the potential as a new skin whitening agent.
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Mission Level Autonomy for USSV
Huntsberger, Terry; Stirb, Robert C.; Brizzolara, Robert
2011-01-01
On-water demonstration of a wide range of mission-proven, advanced technologies at TRL 5+ that provide a total integrated, modular approach to effectively address the majority of the key needs for full mission-level autonomous, cross-platform control of USV s. Wide baseline stereo system mounted on the ONR USSV was shown to be an effective sensing modality for tracking of dynamic contacts as a first step to automated retrieval operations. CASPER onboard planner/replanner successfully demonstrated realtime, on-water resource-based analysis for mission-level goal achievement and on-the-fly opportunistic replanning. Full mixed mode autonomy was demonstrated on-water with a seamless transition between operator over-ride and return to current mission plan. Autonomous cooperative operations for fixed asset protection and High Value Unit escort using 2 USVs (AMN1 & 14m RHIB) were demonstrated during Trident Warrior 2010 in JUN 2010
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Space Mission Human Reliability Analysis (HRA) Project
Boyer, Roger
2014-01-01
The purpose of the Space Mission Human Reliability Analysis (HRA) Project is to extend current ground-based HRA risk prediction techniques to a long-duration, space-based tool. Ground-based HRA methodology has been shown to be a reasonable tool for short-duration space missions, such as Space Shuttle and lunar fly-bys. However, longer-duration deep-space missions, such as asteroid and Mars missions, will require the crew to be in space for as long as 400 to 900 day missions with periods of extended autonomy and self-sufficiency. Current indications show higher risk due to fatigue, physiological effects due to extended low gravity environments, and others, may impact HRA predictions. For this project, Safety & Mission Assurance (S&MA) will work with Human Health & Performance (HH&P) to establish what is currently used to assess human reliabiilty for human space programs, identify human performance factors that may be sensitive to long duration space flight, collect available historical data, and update current tools to account for performance shaping factors believed to be important to such missions. This effort will also contribute data to the Human Performance Data Repository and influence the Space Human Factors Engineering research risks and gaps (part of the HRP Program). An accurate risk predictor mitigates Loss of Crew (LOC) and Loss of Mission (LOM).The end result will be an updated HRA model that can effectively predict risk on long-duration missions.
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GSFC Safety and Mission Assurance Organization
Kelly, Michael P.
2010-01-01
This viewgraph presentation reviews NASA Goddard Space Flight Center's approach to safety and mission assurance. The contents include: 1) NASA GSFC Background; 2) Safety and Mission Assurance Directorate; 3) The Role of SMA-D and the Technical Authority; 4) GSFC Mission assurance Requirements; 5) GSFC Systems Review Office (SRO); 6) GSFC Supply Chain Management Program; and 7) GSFC ISO9001/AS9100 Status Brief.
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Does unconscious stress play a role in prolonged cardiovascular stress recovery?
Brosschot, J F; Geurts, S A E; Kruizinga, I; Radstaak, M; Verkuil, B; Quirin, M; Kompier, M A J
2014-08-01
According to recent insights, humans might not be aware of a substantial part of their cognitive stress representations while these still have prolonged physiological effects. 'Unconscious stress' can be measured by implicit affect (IA) tests. It was shown that IA predicts physiological stress responses, in fact better than explicit ('conscious') affect. It is not known yet whether IA is associated with concurrent prolonged stress responses. In two studies (n = 62 and 123), anger harassment was used to induce stress. Blood pressure (BP) and heart rate (HR) were measured continuously. During BP and HR recovery, IA was measured by an 'anger' version of the implicit association test (IAT) or the implicit positive and negative affect test (IPANAT). Blood pressure and HR increased during anger harassment and recovery afterwards. When using the IPANAT BP recovery levels were lower when positive IA was high and higher when negative IA was high, independent of explicit affect and rumination. These results were not found using the IAT. These results provide preliminary evidence that physiological stress recovery is associated with IA. This is in line with the theory that unconscious stress is responsible for a-possibly considerable-part of unhealthy prolonged stress-related physiological activity. Copyright © 2014 John Wiley & Sons, Ltd.
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Directory of Open Access Journals (Sweden)
John P. O’Laughlin
2016-01-01
Full Text Available We present a case of a syncopal episode resulting from significant QT interval prolongation in a patient on hydroxychloroquine for the treatment of systemic lupus erythematosus and end stage renal disease. The patient had been treated with hydroxychloroquine for two years prior to presentation. After thorough workup for secondary causes of QT interval prolongation hydroxychloroquine was discontinued and the patient’s QT interval shortened. The patient was treated with mexiletine to prevent sudden ventricular arrhythmias, which was unique compared to other documented cases in which lidocaine was used. The patient was noted to have mild prolongation of the QT interval on electrocardiogram prior to initiation of hydroxychloroquine therapy which was exacerbated by its use and may have been caused due to toxicity from underlying renal failure.
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Jono, Takashi; Arai, Katsuyoshi
2017-11-01
The Optical Inter-orbit Communications Engineering Test Satellite (OICETS) was successfully launched on 23th August 2005 and thrown into a circular orbit at the altitude of 610 km. The main mission is to demonstrate the free-space inter satellite laser communications with the cooperation of the Advanced Relay and Technology Mission (ARTEMIS) geostationary satellite developed by the European Space Agency. This paper presents the overview of the OICETS and laser terminal, a history of international cooperation between Japan Aerospace Exploration Agency (JAXA) and ESA and typical results of the inter-orbit laser communication experiment carried out with ARTEMIS.
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1985-01-01
The 51-J mission insignia, designed by Atlantis's first crew, pays tribute to the Statue of Liberty and the ideas it symbolizes. The historical gateway figure bears additional significance for Astronauts Karol J. Bobko, mission commander; and Ronald J. Grabe, pilot, both New Your Natives.
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Prolonged hypothyroidism severely reduces ovarian follicular reserve in adult rats
Meng, Li; Rijntjes, Eddy; Swarts, Hans J.M.; Keijer, Jaap; Teerds, Katja J.
2017-01-01
Background: There is substantial evidence both in humans and in animals that a prolonged reduction in plasma thyroid hormone concentration leads to reproductive problems, including disturbed folliculogenesis, impaired ovulation and fertilization rates, miscarriage and pregnancy complications. The
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Dalla Pozza, Robert; Bechtold, Susanne; Urschel, Simon; Netz, Heinrich; Schwarz, Hans-Peter
2009-01-01
Turner syndrome (TS) is the most common sex chromosome abnormality in females. Recently, a prolongation of the rate-corrected QT (QTc) interval in the electrocardiogram (ECG) of TS patients has been reported. A prolonged QTc interval has been correlated to an increased risk for sudden cardiac death, and medical treatment is warranted in patients with congenital long QT syndrome (LQTS). Additionally, several drugs of common use are contraindicated in LQTS because of their effects on myocardial repolarization. The importance of the QTc prolongation in TS patients is not known at present. Eighteen TS patients with a prolonged QTc interval (group 1) and 11 TS patients with a normal QTc interval (group 2) (mean age 12.6+/-3.1 vs. 11.8+/-2.1 years, respectively) were tested. The QTc interval was calculated during exercise testing and during 24-h ECG recordings. None of the patients experienced adverse cardiac events during the tests. The mean QTc interval decreased from 0.467 to 0.432 s in group 1 and from 0.432 to 0.412 s in group 2. During the 24-h ECG, the maximum QTc interval was significantly prolonged in group 1 (0.51 vs. 0.465 s, pinformation about the cardiac risk in the single TS patient with a prolonged QTc interval. This helps in counseling these girls, as clear therapeutic guidelines are currently lacking.
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International Nuclear Information System (INIS)
Nomura, Takaharu
2006-01-01
We previously showed that Type II diabetes model mice prolonged of their life span by life long low dose rate irradiation. We also found that antioxidant function in variety tissues of some strain of mice were enhancement after low dose/low dose rate irradiation. The prolongation of life span might depend on certain damaged level of reactive oxygen species. We thought the effect of the prolongation was due to the enhancement of the antioxidant activities after irradiation. We investigated whether the enhancement of antioxidant activities after low dose rate irradiation had an effect on life span prolongation. Four-week-old female human premature-aging syndrome model mice, kl/kl (klotho) mice, which the life span of this model mouse is about 65 days, were irradiated with gamma rays at 0.35, 0.70 or 1.2 mGy/hr. The 0.70 mGy/hr-irradiated group remarkably effected on the prolongation of their life span. Some mice of the group were extremely survived for about and more 100 days. Antioxidant activities in the irradiated groups were enhancement by low dose rate irradiation, however the dependence of the dose rates were not clearly difference. These results suggest that the antioxidant activities in this model mouse were enhanced by the low dose rate irradiation, and may make it possible to prolong the life span of this mouse. (author)
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Forgan, D. H.; Nichol, R. C.
2011-04-01
The Square Kilometre Array (SKA) will operate in frequency ranges often used by military radar and other communications technology. It has been shown that if extraterrestrial intelligences (ETIs) communicate using similar technology, then the SKA should be able to detect such transmissions up to distances of ~100 pc (~300 light years) from Earth. However, Mankind has greatly improved its communications technology over the last century, dramatically reducing signal leakage and making the Earth ‘radio quiet’. If ETIs follow the same pattern as the human race, will we be able to detect their signal leakage before they become radio quiet? We investigate this question using Monte Carlo realization techniques to simulate the growth and evolution of intelligent life in the Galaxy. We show that if civilizations are ‘human’ in nature (i.e. they are only ‘radio loud’ for ~100 years, and can only detect each other with an SKA-like instrument out to 100 pc, within a maximum communication time of 100 years), then the probability for such civilizations accidentally detecting each other is low (~10-7), much lower than if other, dedicated communication techniques are permissible (e.g. optical SETI or neutrino communication).
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The Mothership Mission Architecture
Ernst, S. M.; DiCorcia, J. D.; Bonin, G.; Gump, D.; Lewis, J. S.; Foulds, C.; Faber, D.
2015-12-01
The Mothership is considered to be a dedicated deep space carrier spacecraft. It is currently being developed by Deep Space Industries (DSI) as a mission concept that enables a broad participation in the scientific exploration of small bodies - the Mothership mission architecture. A Mothership shall deliver third-party nano-sats, experiments and instruments to Near Earth Asteroids (NEOs), comets or moons. The Mothership service includes delivery of nano-sats, communication to Earth and visuals of the asteroid surface and surrounding area. The Mothership is designed to carry about 10 nano-sats, based upon a variation of the Cubesat standard, with some flexibility on the specific geometry. The Deep Space Nano-Sat reference design is a 14.5 cm cube, which accommodates the same volume as a traditional 3U CubeSat. To reduce cost, Mothership is designed as a secondary payload aboard launches to GTO. DSI is offering slots for nano-sats to individual customers. This enables organizations with relatively low operating budgets to closely examine an asteroid with highly specialized sensors of their own choosing and carry out experiments in the proximity of or on the surface of an asteroid, while the nano-sats can be built or commissioned by a variety of smaller institutions, companies, or agencies. While the overall Mothership mission will have a financial volume somewhere between a European Space Agencies' (ESA) S- and M-class mission for instance, it can be funded through a number of small and individual funding sources and programs, hence avoiding the processes associated with traditional space exploration missions. DSI has been able to identify a significant interest in the planetary science and nano-satellite communities.
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Core Science Systems--Mission overview
Gallagher, Kevin T.
2012-01-01
The Core Science Systems Mission Area delivers nationally focused Earth systems and information science that provides fundamental research and data that underpins all Mission Areas of the USGS, the USGS Science Strategy, and Presidential, Secretarial, and societal priorities. —Kevin T. Gallagher, Associate Director, Core Science Systems