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Sample records for proliferation issues related

  1. Managing Proliferation Issues with Iran

    International Nuclear Information System (INIS)

    Nelson, C. Richard; Saltiel, David H.

    2002-01-01

    Any government in Tehran will be inclined to seek weapons of mass destruction (WMD) and missile delivery options given the realities of its strategic environment. These weapons might help Iran to deter potential external threats, to achieve equality with other major regional powers armed with WMD, and to attain self-reliance in national security, given the isolating experience of arms embargoes. A more pluralist leadership in the future, however, may examine broader choices and trade-offs, and perhaps be less likely to cross key thresholds in WMD acquisition. In any event, Iran's WMD behavior is likely to be determined by both external factors, mainly the availability of crucial components, and internal factors, including calculations of costs, risks, and benefits. Among the benefits, psychological factors, such as prestige, will play an important role. Other important factors that might well shape Iran's WMD behavior include developments in Iraq, relations with the United States and other Gulf states, Israeli-Palestinian relations and the future price of oil. This paper offers recommendations on how the United States can best hope to influence Iranian decisions regarding the acquisition of WMD and missile delivery systems if the United States decides to pursue more direct engagement with Tehran. An engagement-nonproliferation strategy should involve at least three types of parallel efforts: public, private and indirect. Public efforts should seek to create a more positive, less-threatening image of the United States among opinion leaders in Iran. Private efforts should seek to determine the purposes, nature and extent of Iran's efforts to develop WMD and missiles and to suggest better alternatives for Iran's security and prestige needs. Indirect efforts should involve key third countries and organizations in an attempt both to address Iran's security concerns and to deny Iran access to critical WMD and missile technology and components. Russian policy, in

  2. Nuclear power and the proliferation issue

    International Nuclear Information System (INIS)

    Marshall, W.

    1978-02-01

    The purpose of the lecture is to discuss nuclear proliferation, analyse which problems are real and which are a misapprehension, and to suggest a way forward which retains the benefits of nuclear power while providing a more certain protection against undesirable proliferation. After an introductory section the lecture continues under the following headings: plutonium production and accessibility; the use of plutonium; fast reactor fuel; the interim period; conclusions. (U.K.)

  3. Managing Proliferation Issues with Iran; FINAL

    International Nuclear Information System (INIS)

    Nelson, C. Richard; Saltiel, David H.

    2002-01-01

    Any government in Tehran will be inclined to seek weapons of mass destruction (WMD) and missile delivery options given the realities of its strategic environment. These weapons might help Iran to deter potential external threats, to achieve equality with other major regional powers armed with WMD, and to attain self-reliance in national security, given the isolating experience of arms embargoes. A more pluralist leadership in the future, however, may examine broader choices and trade-offs, and perhaps be less likely to cross key thresholds in WMD acquisition. In any event, Iran's WMD behavior is likely to be determined by both external factors, mainly the availability of crucial components, and internal factors, including calculations of costs, risks, and benefits. Among the benefits, psychological factors, such as prestige, will play an important role. Other important factors that might well shape Iran's WMD behavior include developments in Iraq, relations with the United States and other Gulf states, Israeli-Palestinian relations and the future price of oil. This paper offers recommendations on how the United States can best hope to influence Iranian decisions regarding the acquisition of WMD and missile delivery systems if the United States decides to pursue more direct engagement with Tehran. An engagement-nonproliferation strategy should involve at least three types of parallel efforts: public, private and indirect. Public efforts should seek to create a more positive, less-threatening image of the United States among opinion leaders in Iran. Private efforts should seek to determine the purposes, nature and extent of Iran's efforts to develop WMD and missiles and to suggest better alternatives for Iran's security and prestige needs. Indirect efforts should involve key third countries and organizations in an attempt both to address Iran's security concerns and to deny Iran access to critical WMD and missile technology and components. Russian policy, in

  4. Nuclear power and the proliferation issue

    International Nuclear Information System (INIS)

    Marshall, W.

    1978-02-01

    This lecture addresses the question of ''accessibility'' of plutonium as it would arise in fully commercial LMFBR and LWR once-through operations. It is pointed out that the storage of spent LWR fuel results in the progressive accumulation of plutonium which becomes increasingly accessible with time (the ''plutonium mine'') whereas with the LMFBR, economic considerations demand the rapid recycle of plutonium. Furthermore, the fast breeder reactor is primarily a plutonium incinerator, the net production of plutonium being rather small and controllable so as not to exceed society's needs for new energy supplies. An eight-point world nuclear development programme is suggested, taking full note of non-proliferation considerations

  5. Space proliferation versus space-type dissemination: from semantic issues to political issues

    International Nuclear Information System (INIS)

    Gaillard-Sborowsky, Florence

    2015-01-01

    The space and ballistic capabilities relationships are regularly revisited in forums on international security, in particular about Iran and North Korea cases. The term 'space proliferation' is commonly used by analogy with nuclear proliferation. However, is this analogy relevant? Beyond the semantic aspects, this shift raises political issues that this paper will consider. The study of the assumptions regarding the analysis of nuclear and missile proliferation and their space counterparts will highlight some approximations and presuppositions, such as the amalgam between sounding rockets, launchers and missiles technologies, in order to suggest new thinking of these sensitive issues. (author)

  6. Nuclear power and the non-proliferation issue

    International Nuclear Information System (INIS)

    1978-12-01

    This leaflet, issued by the British Nuclear Forum on behalf of the industry, seeks first to place the problem of reconciling the need for nuclear power with its possible weapon uses in a historical perspective. Secondly, it describes the technical and political measures which are now taken, and others which could be introduced in order to ensure that nuclear power, which offers the cheapest and safest large-scale energy source for the future, can be made available without contributing to the proliferation of nuclear weapons. Headings are: introduction; the early years; the IAEA; uranium enrichment; plutonium; secrecy has failed; the Non-Proliferation Treaty; the London Suppliers Group; the situation today; the British position; conclusions. (U.K.)

  7. Position paper on nuclear proliferation issues preventing nuclear proliferation. A duty for the nuclear community

    Energy Technology Data Exchange (ETDEWEB)

    Goldschmidt, Pierre; Bonin, Bernard [ENS High Scientific Council, Brussels (Belgium)

    2010-06-15

    The production of electricity from nuclear power plants is widely seen today as having an increasing role to play in meeting global energy requirements in a sustainable manner. Conscious of the inherently sensitive nature of nuclear technology and materials the ENS-HSC (European Nuclear Society - High Scientific Council) is well aware that a severe safety, security, environmental or proliferation mishap stemming from nuclear energy anywhere in the world would undermine the potential for nuclear energy to contribute to the global energy supply and the minimization of harmful carbon emissions. While the safety of nuclear power plants has continuously improved over the last three decades, the same degree of success cannot be claimed when it comes to the achievements of the international community in stemming the risk of nuclear weapons proliferation. This unfortunate situation is due to both technical and political reasons. The European nuclear industry is committed to the exclusively peaceful use of nuclear energy and to export nuclear facilities and related materials, equipment and technology solely in accordance with relevant national export laws and regulations, Nuclear Suppliers Group guidelines and pertinent United Nations Security Council Resolutions. The ENS-HSC considers that, as a manifestation of their strong commitment to nonproliferation, it is important for the nuclear industry to pay special attention to and promote proliferation-resistant designs and to take IAEA safeguards requirements into account at the design stage. Preventing nuclear proliferation is primarily the responsibility of states but, as major stakeholders, the nuclear industry and scientific community should actively support nuclear disarmament as foreseen in the Non-Proliferation Treaty and measures necessary to strengthen the non-proliferation regime, particularly the international control of the flux of nuclear material and technology. (orig.)

  8. Position paper on nuclear proliferation issues preventing nuclear proliferation. A duty for the nuclear community

    International Nuclear Information System (INIS)

    Goldschmidt, Pierre; Bonin, Bernard

    2010-01-01

    The production of electricity from nuclear power plants is widely seen today as having an increasing role to play in meeting global energy requirements in a sustainable manner. Conscious of the inherently sensitive nature of nuclear technology and materials the ENS-HSC (European Nuclear Society - High Scientific Council) is well aware that a severe safety, security, environmental or proliferation mishap stemming from nuclear energy anywhere in the world would undermine the potential for nuclear energy to contribute to the global energy supply and the minimization of harmful carbon emissions. While the safety of nuclear power plants has continuously improved over the last three decades, the same degree of success cannot be claimed when it comes to the achievements of the international community in stemming the risk of nuclear weapons proliferation. This unfortunate situation is due to both technical and political reasons. The European nuclear industry is committed to the exclusively peaceful use of nuclear energy and to export nuclear facilities and related materials, equipment and technology solely in accordance with relevant national export laws and regulations, Nuclear Suppliers Group guidelines and pertinent United Nations Security Council Resolutions. The ENS-HSC considers that, as a manifestation of their strong commitment to nonproliferation, it is important for the nuclear industry to pay special attention to and promote proliferation-resistant designs and to take IAEA safeguards requirements into account at the design stage. Preventing nuclear proliferation is primarily the responsibility of states but, as major stakeholders, the nuclear industry and scientific community should actively support nuclear disarmament as foreseen in the Non-Proliferation Treaty and measures necessary to strengthen the non-proliferation regime, particularly the international control of the flux of nuclear material and technology. (orig.)

  9. The Asia-Pacific region: non-proliferation and other disarmament issues

    International Nuclear Information System (INIS)

    1992-01-01

    In the past few years, the United States and the former Soviet Union began to adjust their force structures in Asia-Pacific region. In this respect, a large range of issues have been raised in discussions on the non-proliferation of nuclear and other weapons of mass destruction. Apart from the issues and trends related to proliferation, military expenditure, arms transfer and other disarmament matters, the specific situations in the respective subregions of South-East Asia, South Asia and North-East Asia were discussed. Comprehensive and verified commitments not to possess any such weapons is stressed as the main goal of the meeting. It is vitally important that opportunities that were opened should be seized to prevent the spread of nuclear, chemical, biological as well as highly destabilizing conventional weapons

  10. Strategies for managing nuclear proliferation: economic and political issues

    International Nuclear Information System (INIS)

    Brito, D.L.; Intriligator, M.D.; Wick, A.E.

    1983-01-01

    Several new ways of approaching nuclear-weapons proliferation emerged at an April 1982 conference at Tulane University. The new ideas use statistical techniques to emphasize political and economic rather than technological determinants, recognize the possibility that proliferation could have a stabilizing influence, shift their emphasis from eliminating to managing proliferation, and focus on regional factors. The four divisions of this book reflect these new trends. Separate abstracts were prepared for the 18 individual papers selected for the Energy Data Base (EDB) and Energy Abstracts for Policy Analysis (EAPA). 6 figures, 23 tables

  11. Issues related to geothermal development

    International Nuclear Information System (INIS)

    Lesperance, G.O.

    1990-01-01

    This paper reports on a number of potential barriers to geothermal development in Hawaii which have been overcome but some remain. Efforts continue to address issues relating to transmission, project economics, the regulatory process, resource verification, and public acceptance

  12. Proliferation resistance criteria for fissile material disposition issues

    International Nuclear Information System (INIS)

    Rutherford, D.A.; Fearey, B.L.; Markin, J.T.; Close, D.A.; Tolk, K.M.; Mangan, D.L.; Moore, L.

    1995-01-01

    The 1994 National Acdaemy of Sciences study ''Management and Disposition of Excess Weapons Plutonium'' defined options for reducing the national and international proliferation risks of materials declared excess to the nuclear weapons program. This paper proposes criteria for assessing the proliferation resistance of these options as well defining the ''Standards'' from the report. The criteria are general, encompassing all stages of the disposition process from storage through intermediate processing to final disposition including the facilities, processing technologies and materials, the level of safeguards for these materials, and the national/subnational threat to the materials

  13. Long-term proliferation and safeguards issues in future technologies

    International Nuclear Information System (INIS)

    Keisch, B.; Auerbach, C.; Fainberg, A.; Fiarman, S.; Fishbone, L.G.; Higinbotham, W.A.; Lemley, J.R.; O'Brien, J.

    1986-02-01

    The purpose of the task was to assess the effect of potential new technologies, nuclear and non-nuclear, on safeguards needs and non-proliferation policies, and to explore possible solutions to some of the problems envisaged. Eight subdivisions were considered: New Enrichment Technologies; Non-Aqueous Reprocessing Technologies; Fusion; Accelerator-Driven Reactor Systems; New Reactor Types; Heavy Water and Deuterium; Long-Term Storage of Spent Fuel; and Other Future Technologies (Non-Nuclear). For each of these subdivisions, a careful review of the current world-wide effort in the field provided a means of subjectively estimating the viability and qualitative probability of fruition of promising technologies. Technologies for which safeguards and non-proliferation requirements have been thoroughly considered by others were not restudied here (e.g., the Fast Breeder Reactor). The time scale considered was 5 to 40 years for possible initial demonstration although, in some cases, a somewhat optimistic viewpoint was embraced. Conventional nuclear-material safeguards are only part of the overall non-proliferation regime. Other aspects are international agreements, export controls on sensitive technologies, classification of information, intelligence gathering, and diplomatic initiatives. The focus here is on safeguards, export controls, and classification

  14. Long-term proliferation and safeguards issues in future technologies

    Energy Technology Data Exchange (ETDEWEB)

    Keisch, B.; Auerbach, C.; Fainberg, A.; Fiarman, S.; Fishbone, L.G.; Higinbotham, W.A.; Lemley, J.R.; O' Brien, J.

    1986-02-01

    The purpose of the task was to assess the effect of potential new technologies, nuclear and non-nuclear, on safeguards needs and non-proliferation policies, and to explore possible solutions to some of the problems envisaged. Eight subdivisions were considered: New Enrichment Technologies; Non-Aqueous Reprocessing Technologies; Fusion; Accelerator-Driven Reactor Systems; New Reactor Types; Heavy Water and Deuterium; Long-Term Storage of Spent Fuel; and Other Future Technologies (Non-Nuclear). For each of these subdivisions, a careful review of the current world-wide effort in the field provided a means of subjectively estimating the viability and qualitative probability of fruition of promising technologies. Technologies for which safeguards and non-proliferation requirements have been thoroughly considered by others were not restudied here (e.g., the Fast Breeder Reactor). The time scale considered was 5 to 40 years for possible initial demonstration although, in some cases, a somewhat optimistic viewpoint was embraced. Conventional nuclear-material safeguards are only part of the overall non-proliferation regime. Other aspects are international agreements, export controls on sensitive technologies, classification of information, intelligence gathering, and diplomatic initiatives. The focus here is on safeguards, export controls, and classification.

  15. Cancer survivors. Work related issues.

    Science.gov (United States)

    Schultz, Pamela N; Beck, Martha L; Stava, Charles; Sellin, Rena V

    2002-05-01

    New and more effective treatments for cancer have resulted in individuals living longer with a better quality of life. Many more survivors are employed in the workplace. Cancer is no longer only an issue for survivors and their families; it has become an issue for the employer and the workplace. This article describes survey results of 4,364 long term cancer survivors in which they were asked to respond to items describing their ability to work, job discrimination, and quality of life. Thirty-five percent of survivors were working at the time they completed the survey, and 8.5% considered themselves unable to work. This research has shown that age, gender, ethnic group, and cancer type affected the working status of the survivors. Of survivors continuing to work, 7.3% indicated they had experienced job discrimination. The results indicate most cancer survivors do not perceive employment related problems, and are readily assimilated into the work force. Job discrimination and the ability to work is a quality of life issue.

  16. Gender relations and economic issues.

    Science.gov (United States)

    Elson, D

    1993-10-01

    While most discussions of economic issues pay no explicit attention to gender relations, most economic policy is marked by male bias which provides women with an unequal access to resources. This situation exists because most economists, officials, and business managers lack the imagination to see the gender impact of economic issues and most women's groups and researchers lack the language to portray this connection. This article explores some aspects of this gap and aims to provide women with the ability to effectively discuss economic issues. After an introduction, the article considers the basic problem caused by the fact that the economy is defined primarily in terms of money-making activities. This leads to a male bias since much of women's work occurs outside of the monetary sphere. The next section looks at how a failure to understand the significance of gender relations will interfere with the fulfillment of policy objectives. This discussion is followed by a description of how cutbacks in government expenditures increase the burden on women who must replace the services. Problems with the option of the private-sector replacing government services, such as the fact that increasing disposable income in households does not guarantee that unpaid labor will be reduced and the fact that the private sector may fail to expand in a productive way, are covered. The article then touches on the new emphasis placed by some economists and policy makers on cooperative and interactive solutions to these problems and ends by mentioning three new initiatives which seek to build capacity for gender-aware economic analysis: the development of a training program at Manchester University in the UK, coordination of an international research workshop by the University of Utah in the US, and development of an international association for feminist economics based in the US.

  17. Issues of weapons of mass destruction non-proliferation in Tajikistan

    International Nuclear Information System (INIS)

    Mirsaidov, U.M.

    2010-01-01

    This article is devoted to issues of weapons of mass destruction non-proliferation in Tajikistan. Over a period of 20 century, starting from First World War, the weapons of mass destruction arouse serious concern of world community. Geneva protocol of 1925 prohibits the use of chemical and biological weapons. Once nuclear weapon was created, the weapons of mass destruction distributions become the subject of high concern. Besides, during the end of 'cold war', regional conflicts, collapse of Soviet Union, as well as access to sensitive technologies considerably increase the danger of weapons of mass destruction distribution. More than 10 countries have active programs, relating to weapons of mass destruction and, possibly, more than ten countries have potential to start implementing such kinds of programs. Nowadays, trans national organized criminal groups and international terrorist networks are appeared in the world scene, which show interest in obtaining an access to sensitive materials, technologies, weapons and their distribution. After 11 September events, the risk of such weapons of mass destruction components use by such forces for Governments blackmail become real scene, which, despite of low possibility of this threat implementation, could have very serious and disastrous consequences. International community responded to these problems and challenges, basically through the following actions, which is detailed regime development of multilateral international treaties, directed to weapons of mass destruction distribution prevention. Non-proliferation treaty of nuclear weapons, Convention on prohibition of chemical weapons and Convention on prohibition of biological and toxin weapons are some of them. As it is known, Tajikistan signed all these treaties. For different reasons these treaties were subject of serious tests. Nuclear weapons tests in India and Pakistan in 1998 year, actual Israel status as state having nuclear weapon and North Korean program on

  18. U.S.-China Relations: Policy Issues

    Science.gov (United States)

    2011-01-12

    global issues on which the Obama Administration has sought to work with China are the international financial crisis, climate change, and nuclear non-proliferation. In remarks in July 2009, President Obama declared that partnership between the United States and China was a prerequisite for progress on many of the most pressing global challenges. Continuing major bilateral issues in the relationship include trade and...into the Obama Administration, U.S. officials point to some successes in their efforts to work with China on global issues , including

  19. Non-proliferation and safeguards aspects. Key issue paper no. 5

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    This paper examines the current nuclear non-proliferation regime (Section 2) and the issues most likely to arise as the civil nuclear fuel cycle develops over the next 50 years (Section 3). Section 4 deals with fuel cycles and nuclear material inventories. 14 refs.

  20. Accounting-related transmission issues

    International Nuclear Information System (INIS)

    Niehaus, M.; Bjorn, P.; Pate, G.

    1999-01-01

    Various initiatives have been undertaken by the Federal Energy Regulatory Commission (FERC) to deregulate wholesale electric energy markets. These initiatives have focused on restructuring the transmission systems in the US and recently have culminated in a proposal requiring formation of and participation in regional transmission organizations. The overall form of regulation selected to determine rates for transmission entities as well as underlying regulatory decisions reached on key issues will have profound implications for transmission entities. For example, traditional cost-based regulation would require one set of accounting and reporting rules, while incentive-based regulation may not be subject to those same rules. An overview of some of the major accounting and financial reporting issues that will need to be considered is presented

  1. Robustness-related issues in speaker recognition

    CERN Document Server

    Zheng, Thomas Fang

    2017-01-01

    This book presents an overview of speaker recognition technologies with an emphasis on dealing with robustness issues. Firstly, the book gives an overview of speaker recognition, such as the basic system framework, categories under different criteria, performance evaluation and its development history. Secondly, with regard to robustness issues, the book presents three categories, including environment-related issues, speaker-related issues and application-oriented issues. For each category, the book describes the current hot topics, existing technologies, and potential research focuses in the future. The book is a useful reference book and self-learning guide for early researchers working in the field of robust speech recognition.

  2. DOE/LLNL verification symposium on technologies for monitoring nuclear tests related to weapons proliferation

    International Nuclear Information System (INIS)

    Nakanishi, K.K.

    1993-01-01

    The rapidly changing world situation has raised concerns regarding the proliferation of nuclear weapons and the ability to monitor a possible clandestine nuclear testing program. To address these issues, Lawrence Livermore National Laboratory's (LLNL) Treaty Verification Program sponsored a symposium funded by the US Department of Energy's (DOE) Office of Arms Control, Division of Systems and Technology. The DOE/LLNL Symposium on Technologies for Monitoring Nuclear Tests Related to Weapons Proliferation was held at the DOE's Nevada Operations Office in Las Vegas, May 6--7,1992. This volume is a collection of several papers presented at the symposium. Several experts in monitoring technology presented invited talks assessing the status of monitoring technology with emphasis on the deficient areas requiring more attention in the future. In addition, several speakers discussed proliferation monitoring technologies being developed by the DOE's weapons laboratories

  3. Brain death and related issues

    International Nuclear Information System (INIS)

    Akhtar, M.; Mushtaq, S.; Jamil, K.; Ahmed, S.

    2003-01-01

    Concerns about the erroneous diagnosis of death and premature burial have been expressed from times immemorial. Patients with brain stem death have absolutely no chance of recovery. Brain death is considered at par with death in most of the countries. General public in most parts of the world shows reluctance to accept this concept due to different social, cultural and religious backgrounds and state of literacy and awareness. The criteria for the diagnosis of brain death have been established which include certain pre-conditions, exclusions and tests of the brain stem function. These criteria are universally accepted. The criteria in children are somewhat different from the adults. The subject is intimately related with organ transplantation. If the patients is registered as organ donor or the family consents, organs can be harvested from brain dead patients for transplantation. Pakistan is amongst the few countries where no legislation exists to accept brain death as being at par with death of an individual, and to facilitate and regulate, cadaveric organ donation and transplantation. (author)

  4. Plutonium: key issue in nuclear disarmament and non-proliferation of nuclear weapons

    International Nuclear Information System (INIS)

    Yoshisaki, M.B.

    1993-01-01

    The technical report is a 1993 update on weapons-grade plutonium, a key issue in nuclear disarmament. Its vital significance would again be discussed during the fifth and the last Review Conference on the Non-Proliferation Treaty (NPT) for Nuclear Weapons which would end in 1995. Member States shall decide whether an indefinite or conditional extension of NPT is necessary for world peace and international security. Two Non-NPT States, Russia and U.S.A. are in the forefront working for the reduction of nuclear weapons through nuclear disarmament. Their major effort is focused on the implementation of the Strategic Arms Reduction Treaty I and II or START I and II for world peace. The eventual implementation of START I and II would lead to the dismantling of plutonium from nuclear warheads proposed to be eliminated by both countries. This report gives three technical options to be derived from nuclear disarmament issues for the non-proliferation of nuclear weapons: (a) indefinite storage - there is no guarantee that these will not be used in the future (b) disposal as wastes - possible only in principle, because of lack of experience in mixing plutonium with high level wastes, and (c) source of energy - best option in managing stored weapons materials, because it satisfies non-proliferation objectives. It means fuel for energy in Light Water Reactors (LWR) or Fast Breeder Reactors (FBR). (author). 8 refs

  5. Non-proliferation issues for the disposition of fissile materials using reactor alternatives

    International Nuclear Information System (INIS)

    Jaeger, C.D.; Duggan, R.A.; Tolk, K.M.

    1996-01-01

    The Department of Energy (DOE) is analyzing long-term storage imposition options for excess weapons-usable fissile materials. A number of the disposition alternatives are being considered which involve the use of reactors. The various reactor alternatives are all very similar and include front-end processes that could convert plutonium to a usable form for fuel fabrication, a MOX fuel fab facility, reactors to burn the MOX fuel and ultimate disposal of spent fuel in some geologic repository. They include existing, partially completed, advanced or evolutionary light water reactors and Canadian deuterium uranium (CANDU) reactors. In addition to the differences in the type of reactors, other variants on these alternatives are being evaluated to include the location and number of the reactors, the location of the mixed oxide (MOX) fabrication facility, the ownership of the facilities (private or government) and the colocation and/or separation of these facilities. All of these alternatives and their variants must be evaluated with respect to non-proliferation resistance. Both domestic and international safeguards support are being provided to DOE's Fissile Materials Disposition Program (FMDP) and includes such areas as physical protection, nuclear materials accountability and material containment and surveillance. This paper will focus on how the non-proliferation objective of reducing security risks and strengthening arms reduction will be accomplished and what some of the non-proliferation issues are for the reactor alternatives. Proliferation risk has been defined in terms of material form, physical environment, and the level of security and safeguards that is applied to the material. Metrics have been developed for each of these factors. The reactor alternatives will be evaluated with respect to these proliferation risk factors at each of the unit process locations in the alternative

  6. RELATIVE PROLIFERATION RISKS FOR NUCLEAR FUEL LEASING ARRANGEMENT

    International Nuclear Information System (INIS)

    CHENG, L.Y.; YUE, M.; BARI, R.A.

    2007-01-01

    The present study demonstrates a probabilistic approach to quantify the proliferation risks of fuel leasing and recycling. A Markov model approach is applied to evaluate the probability of proliferation success by diversion or theft. Proliferation risk is calculated as a product of the probability of success and the corresponding consequences

  7. Fabric quality issues related to apparel merchandising

    CSIR Research Space (South Africa)

    Das, Sonali

    2015-02-01

    Full Text Available The objectives of this study are to develop an understanding of fabric quality related issues and research gaps relevant to apparel manufacturing and merchandising within the South African context. The specific focus is on fabric objective...

  8. Non-proliferation issues for the disposition of fissile materials using reactor alternatives

    International Nuclear Information System (INIS)

    Jaeger, C.D.; Duggan, R.A.; Tolk, K.M.

    1996-01-01

    The Department of Energy (DOE) is analyzing long-term storage on options for excess weapons-usable fissile materials. A number of the disposition alternatives are being considered which involve the use of reactors. The various reactor alternatives are all very similar and include front-end processes that could convert plutonium to a usable form for fuel fabrication, a MOX fuel fab facility, reactors to bum the MOX fuel and ultimate disposal of spent fuel in some geologic repository. They include existing, partially completed, advanced or evolutionary light water reactors and Canadian deuterium uranium (CANDU) reactors. In addition to the differences in the type of reactors, other variants on these alternatives are being evaluated to include the location and number of the reactors, the location of the mixed oxide (MOX) fabrication facility, the ownership of the facilities (private or government) and the colocation and/or separation of these facilities. All of these alternatives and their variants must be evaluated with respect to non-proliferation resistance. Both domestic and international safeguards support are being provided to DOE's Fissile Materials Disposition Program (FMDP) and includes such areas as physical protection, nuclear materials accountability and material containment and surveillance. This paper will focus on how the non-proliferation objective of reducing security risks and strengthening arms reduction will be accomplished and what some of the nonproliferation issues are for the reactor alternatives. Proliferation risk has been defined in terms of material form, physical environment, and the level of security and safeguards that is applied to the material. Metrics have been developed for each of these factors. The reactor alternatives will be evaluated with respect to these proliferation risk factors at each of the unit process locations in the alternative

  9. Issues related to field testing in tuff

    International Nuclear Information System (INIS)

    Zimmerman, R.M.

    1982-01-01

    This paper has brought out the unique properties of tuffs and related them to needs associated with their use as a host rock for a high level nuclear waste repository. Major issues of temperature, pore water, joints, and depositional patterns have been identified and related responses and impacts outlined in Table 1. Planned experiments have been outlined and their relationships to the rock mechanics issues summarized in Table 2. The conclusions from this paper are: (1) tuff is a complex rock and basic phenomenological understanding is incomplete; and (2) available field test facilities will be used for a series of experiments designed to improve phenomenological understanding and support repository design efforts

  10. Problems and Issues Related to Alternative Education.

    Science.gov (United States)

    Pilat, Mary

    1997-01-01

    Symposium participants identified policy issues in these areas related to alternative education for at-risk youth: choice, equity, public perception, definition, philosophy, stakeholder involvement, evaluation, staffing, curriculum, governance, and financing. Public discourse and policy discussion were considered essential to implementing…

  11. Addressing Measurement Issues Related to Bullying Involvement

    Science.gov (United States)

    Casper, Deborah M.; Meter, Diana J.; Card, Noel A.

    2015-01-01

    In this article, we address measurement issues related to select aspects of bullying involvement with the goal of moving psychometrically sound measurement practices toward applied bullying research. We first provide a nontechnical introduction to psychometric considerations in measuring bullying involvement, highlighting the importance of…

  12. U.S.-China Relations: Policy Issues

    Science.gov (United States)

    2010-03-12

    China Relations: Policy Issues Congressional Research Service 8 Center; the U.S.-China Energy Efficiency Action Plan; and the U.S.-China Energy...January 25, 2010. 28 Liu Shengjun, “How to Better Use Forex Reserves,” China Daily, January 13, 2010. 29 Paul R. La Monica, “China Still Likes Us…For...or commercialization of carbon capture and sequestration technology, improve energy efficiency , or renewable energy sources. H.R. 2454 Waxman

  13. Abstracts of 3. International scientific-practical conference 'Semipalatinsk Test Site. Radiation Legacy and Non-proliferation Issues'

    International Nuclear Information System (INIS)

    2008-01-01

    The Conference gathered representatives of more than 25 countries and international organizations. In the Conference among with actual problems of current environment conditions in Kazakhstan, perspective trends in the field of radiation protection, radio-ecological and radiobiological research and issues of international co-operation in support of non-proliferation regime, other advanced scientific projects were considered [ru

  14. Labour Rights Protection in Industrial Relations Issues

    Directory of Open Access Journals (Sweden)

    Eko Adi Susanto

    2015-12-01

    Full Text Available Many violations of the terms of employment at Surabaya, employment protection  and working conditions for workers who are not provided by employers to the maximum, according to the legislation in force, while the legal protection for workers constrained because of the weakness in the system of employment law, both the substance and the culture built by governments and companies. How To Cite: Susanto, E. (2015. Labour Rights Protection in Industrial Relations Issues. Rechtsidee, 2(2, 109-120. doi:http://dx.doi.org/10.21070/jihr.v2i2.78

  15. Intervention on non-proliferation issues at IAEA Board of Governors, 17 June 2009, Vienna, Austria

    International Nuclear Information System (INIS)

    ElBaradei, M.

    2009-01-01

    The IAEA's Director General Dr. Mohamed ElBarardei reported that the IAEA has been dealing with the verification issue in North Korea for seventeen years and things have gone from bad to worse. It started to improve when there was a dialogue. When there was no dialogue, things got much worse. There was a dialogue under the agreed framework and there were no weapons, just spent fuel under an Agency freeze. When the dialogue stopped, there was a nuclear test. With the six-party framework, things started to move and there was a dismantlement and shutdown. But when the six-party talks came to a halt, there was another nuclear test and in addition there was an announcement that North Korea will also start an enrichment programme. This means that it is important to have a meaningful dialogue between parties and that they talk to each other and understand the security dimension of proliferation issues. The Director General said that he will not have anything to report at the next Board of Governors meeting since the IAEA is not in North Korea and is not part of the six party talks. Since more and more countries are going into enrichment and fuel cycle processes it is recommended that there should be total multinationalization of the fuel cycle, as part of a world free of nuclear weapons and on the basis of equality and universality. There are four pillars which have to work together: the Agency, the Security Council, multilateral dialogues and bilateral talks. What we can do can be very much influenced by the Security Council, by multilateral dialogue and by bilateral talks. The Security Council should not necessarily mean just sanctions. The Security Council is supposed to be a forum to try to find solutions. The Security Council is supposed to intervene early and do preventive measures and try to find solutions. When things are moving in the bilateral/multilateral dialogue, such as in the six-party talks, then they move here. When there is a dialogue, there is some

  16. Environmental issues related to uranium mining

    International Nuclear Information System (INIS)

    Gorber, D.M.; Chambers, D.B.

    1983-01-01

    This paper introduces the environmental issues (both real and perceived) associated with uranium exploration, mining, milling, and tailings management. As well, some of the issues pertaining to the closeout of uranium tailings areas are discussed. These issues have received considerable attention in Canada in public inquiries and hearings that have been held across the country. The major conclusions of some of these hearings are also noted

  17. Pertinent issues related to laparoscopic radical prostatectomy

    Directory of Open Access Journals (Sweden)

    Sidney C. Abreu

    2003-12-01

    Full Text Available PURPOSE: We describe the critical steps of the laparoscopic radical prostatectomy (LRP technique and discuss how they impact upon the pertinent issues regarding prostate cancer surgery: blood loss, potency and continence. RESULTS: A major advantage of LRP is the reduced operative blood loss. The precise placement of the dorsal vein complex stitch associated with the tamponading effect of the CO2 pneumoperitoneum significantly decrease venous bleeding, which is the main source of blood loss during radical prostatectomy. At the Cleveland Clinic, the average blood loss of our first 100 patients was 322.5 ml, resulting in low transfusion rates. The continuous venous bleeding narrowed pelvic surgical field and poor visibility can adversely impact on nerve preservation during open radical prostatectomy. Laparoscopy, with its enhanced and magnified vision in a relatively bloodless field allows for excellent identification and handling of the neurovascular bundles. During open retropubic radical prostatectomy, the pubic bone may impair visibility and access to the urethral stump, and the surgeon must tie the knots relying on tactile sensation alone. Consequently, open prostatectomy is associated with a prolonged catheterization period of 2 - 3 weeks. Comparatively, during laparoscopic radical prostatectomy all sutures are meticulously placed and each is tied under complete visual control, resulting in a precise mucosa-to-mucosa approximation. CONCLUSION: The laparoscopic approach may represent a reliable less invasive alternative to the conventional open approach. Despite the encouraging preliminary anatomical and functional outcomes, prospective randomized comparative trials are required to critically evaluate the role of laparoscopy for this sophisticated and delicate operation.

  18. Intent, Capability and Opportunity: A Holistic Approach to Addressing Proliferation as a Risk Management Issue

    Energy Technology Data Exchange (ETDEWEB)

    Amanda Rynes; Trond Bjornard

    2011-07-01

    Currently, proliferation risk assessment models are designed to evaluate only a portion of the overall risk, focusing exclusively on either technological or social factors to determine the extent of a threat. Many of these models are intended to act as a means of predicting proliferation potential rather than assessing the system as a whole, ignoring the ability to enhance mitigating factors and manage, rather just establish the presence of, the threat. While the information garnered through these forms of analysis is necessary, it remains incomplete. By incorporating political, social, economic and technical capabilities as well as human factors such as intent into a single, multi-faceted risk management model, proliferation risk can be evaluated more effectively. Framing this information around how to improve and expand the Regime already in place and establishing where there are gaps in the system allows for a more complete approach to risk management, mitigation and resource allocation. The research conducted here seeks to combine all three elements (intent, capability and opportunity) in a comprehensive evaluation which incorporates an assessment of state-level variables, possible proliferation pathways and technical capability. Each portion of the analysis is carried out independently then combined to illustrate the full scope of a State's nuclear infrastructure while showing areas of weakness in the institutional framework.

  19. Intent, Capability and Opportunity: A Holistic Approach to Addressing Proliferation as a Risk Management Issue

    International Nuclear Information System (INIS)

    Rynes, Amanda; Bjornard, Trond

    2011-01-01

    Currently, proliferation risk assessment models are designed to evaluate only a portion of the overall risk, focusing exclusively on either technological or social factors to determine the extent of a threat. Many of these models are intended to act as a means of predicting proliferation potential rather than assessing the system as a whole, ignoring the ability to enhance mitigating factors and manage, rather just establish the presence of, the threat. While the information garnered through these forms of analysis is necessary, it remains incomplete. By incorporating political, social, economic and technical capabilities as well as human factors such as intent into a single, multi-faceted risk management model, proliferation risk can be evaluated more effectively. Framing this information around how to improve and expand the Regime already in place and establishing where there are gaps in the system allows for a more complete approach to risk management, mitigation and resource allocation. The research conducted here seeks to combine all three elements (intent, capability and opportunity) in a comprehensive evaluation which incorporates an assessment of state-level variables, possible proliferation pathways and technical capability. Each portion of the analysis is carried out independently then combined to illustrate the full scope of a State's nuclear infrastructure while showing areas of weakness in the institutional framework.

  20. Nuclear power plant safety related pump issues

    Energy Technology Data Exchange (ETDEWEB)

    Colaccino, J.

    1996-12-01

    This paper summarizes of a number of pump issues raised since the Third NRC/ASME Symposium on Valve and Pump Testing in 1994. General issues discussed include revision of NRC Inspection Procedure 73756, issuance of NRC Information Notice 95-08 on ultrasonic flow meter uncertainties, relief requests for tests that are determined by the licensee to be impractical, and items in the ASME OM-1995 Code, Subsection ISTB, for pumps. The paper also discusses current pump vibration issues encountered in relief requests and plant inspections - which include smooth running pumps, absolute vibration limits, and vertical centrifugal pump vibration measurement requirements. Two pump scope issues involving boiling water reactor waterlog and reactor core isolation cooling pumps are also discussed. Where appropriate, NRC guidance is discussed.

  1. Nuclear power plant safety related pump issues

    International Nuclear Information System (INIS)

    Colaccino, J.

    1996-01-01

    This paper summarizes of a number of pump issues raised since the Third NRC/ASME Symposium on Valve and Pump Testing in 1994. General issues discussed include revision of NRC Inspection Procedure 73756, issuance of NRC Information Notice 95-08 on ultrasonic flow meter uncertainties, relief requests for tests that are determined by the licensee to be impractical, and items in the ASME OM-1995 Code, Subsection ISTB, for pumps. The paper also discusses current pump vibration issues encountered in relief requests and plant inspections - which include smooth running pumps, absolute vibration limits, and vertical centrifugal pump vibration measurement requirements. Two pump scope issues involving boiling water reactor waterlog and reactor core isolation cooling pumps are also discussed. Where appropriate, NRC guidance is discussed

  2. Issues related to cooperative implementation mechanisms

    International Nuclear Information System (INIS)

    1998-01-01

    This note by the secretariat seeks to focus discussions on some key issues regarding the design and functioning of the three new mechanisms, such as issues concerning mandates, cross-cutting as well as issues concerning individual mechanisms. The note addresses each mechanism separately in view of different origins, approaches, participants and possible applications. Reference is, however, made to similarities among the mechanisms, in particular where coordination of work on methodological and institutional issues and inter-institutional collaboration are concerned. The note suggests, in its concluding part, elements of a work programme up to and, to some extent, beyond COP 4. It draws upon the views submitted by Parties (document FCCC/SB/1998/MISC.1), contains reflections by the secretariat and builds on its consultations with other organizations having activities, under way or planned, that could contribute to the design or operation of the mechanisms. (au)

  3. Bill related to the struggle against proliferation of mass destruction weapons and their vectors

    International Nuclear Information System (INIS)

    2010-01-01

    This bill indicates the modifications brought to different French laws and codes (penal code, defence code, custom code) and defines provisions and penalties within the frame of struggle against the proliferation of weapons of mass destruction (nuclear weapons, biological weapons and toxin-based weapons, chemical weapons), and against the proliferation of their vectors. These modifications, provisions and penalties also concern double-use products. The bill also defines the modifications brought to the French penal procedure code. It finally addresses offenses related to these proliferations which can be considered as an act of terrorism

  4. Modulating Estrogen Receptor-related Receptor-α Activity Inhibits Cell Proliferation*

    OpenAIRE

    Bianco, Stéphanie; Lanvin, Olivia; Tribollet, Violaine; Macari, Claire; North, Sophie; Vanacker, Jean-Marc

    2009-01-01

    High expression of the estrogen receptor-related receptor (ERR)-α in human tumors is correlated to a poor prognosis, suggesting an involvement of the receptor in cell proliferation. In this study, we show that a synthetic compound (XCT790) that modulates the activity of ERRα reduces the proliferation of various cell lines and blocks the G1/S transition of the cell cycle in an ERR...

  5. Global issues related to enteric viral infections.

    Science.gov (United States)

    Desselberger, Ulrich

    2014-01-01

    Acute viral gastroenteritis is a major health issue worldwide and is associated with high annual mortality, particularly in children of developing countries. Rotaviruses, caliciviruses and astroviruses are the main causes. Accurate diagnoses are possible by recently developed molecular techniques. In many setups, zoonotic transmission is an important epidemiological factor. Treatment consists of rehydration and is otherwise symptomatic. The worldwide introduction of universal rotavirus vaccination of infants has significantly reduced rotavirus disease and mortality.

  6. Epidemiological issues related to dose reconstruction

    International Nuclear Information System (INIS)

    Shore, R.E.

    1996-01-01

    When a dose reconstruction is performed around some nuclear site, a decision has to be made as to whether an epidemiologic study should be performed there and, if so, what form the study should take. The goal of this paper is to provide an overview of epidemiologic and biostatistical issues that help determine whether an epidemiologic study around a nuclear facility is worthwhile doing from a scientific standpoint. We are all aware that public health and sociopolitical concerns often assume considerable importance in these decisions, but they will not be considered here. 27 refs., 2 tabs

  7. Environmental issues related to biomass: An overview

    International Nuclear Information System (INIS)

    Hughes, M.; Ranney, J.W.

    1993-01-01

    With public attention increasingly focused on environmentalism and climate change, there is enormous potential for the commercial use of biomass to accelerate. Renewable feedstocks such as biomass can provide more environmentally balanced sources of energy and other non-food products than fossil fuels. Biomass utilization is in a precarious position, however, with public attention increasingly focused on both its potential and the strength of the challenges it faces. The paper is divided into five sections. Section 2 briefly addresses economic environmental issues. The extent to which externalities are accounted for in the market price of fuels plays a significant role in determining both the ultimate size of biofuel markets and the extent of the environmental benefits of feedstock cultivation and conversion processes. Sections 3 through 4 catalogue the main hazards and benefits that are likely to arise in the large scale commercialization of biomass fuel and note where the major uncertainties lay. Environmental issues arise with the cultivation of each feedstock and with each step in the process of its conversion to fuel. Feedstocks are discussed in Section 3 in terms of three main groups; wastes, energy crops, and traditional agricultural crops. In Section 4, conversion processes are also divided into three groups, on the basis of the end energy carrier; gas, liquid, and solid and electricity. Section 5 is devoted to a conclusion and summary

  8. Key Issues on Nuclear Energy Non-proliferation in East Asia

    International Nuclear Information System (INIS)

    Hwang, Yong Soo; Whang, Joo Ho; Lee, Un Chul

    2005-01-01

    Energy demand in East Asia casts a significant challenge to sustainable economy development and socio-political stability in the region which has experienced tensions throughout the history. The energy demand in this region has been dramatically increased since the start of reform in PRC. DPRK is another challenge. The current electricity consumption in DPRK is around 10% of that in ROK. If the economy of PRC continuously grows to the level of neighboring states and if the living standard of DPRK reaches that of ROK, the energy and electricity demand in the region will certainly be out of control unless the proper measures are taken into actions from today. The only feasible energy option is the nuclear one. PRC already proclaimed its ambitious plan to deploy more than 30 reactors in the near future. In addition, a couple of the South Eastern Asian states expressed their willingness to introduce nuclear power plants in the future. The increase in the use of nuclear energy is expected to bring up the nuclear renaissance in the region. However, without the proper mechanisms to supply fresh fuels and to manage spent nuclear fuels with full compliance of nuclear energy nonproliferation, the new development will inevitably cause the instability in the region. So far many interesting proposals on nuclear cooperation in East Asia were announced. Unfortunately, none of them works out properly yet, partly because the old proposals were too political. To restart the engine of the nuclear cooperation and nonproliferation in the region, it is necessary to find out what would be the common interests of the region not so much related to politics. In this paper, some key technical issues are addressed for future regional joint studies

  9. Economic issues relating to power sector

    International Nuclear Information System (INIS)

    Nair, S.K.N.; Mohan, Rakesh

    1998-01-01

    Financial distress alongside high rates of growth, stagnant organizations coexistent with upgraded technologies, richly endowed regions marked by low levels of electricity consumption and the long wait for private power in face of mounting shortfalls are among the contradictions marking the power sector. Decades of public financing support could shore up the rates of growth but forms of past intervention failed to address critical institutional and regulatory issues. Key areas that need intervention have now been identified, although several are yet to be tackled. This paper discusses the more important of the problem areas holding up significant economic gains that could be realized through cost reductions, the needed levels of investments, operation of market forces and targeting of resources to promote equitable growth. The slow pace of progress is a matter for concern. Effectiveness of many of the policy initiatives of government is also dependent on providing well thought out policy supports. (author)

  10. Issues related to the Fermion mass problem

    Science.gov (United States)

    Murakowski, Janusz Adam

    1998-09-01

    This thesis is divided into three parts. Each illustrates a different aspect of the fermion mass issue in elementary particle physics. In the first part, the possibility of chiral symmetry breaking in the presence of uniform magnetic and electric fields is investigated. The system is studied nonperturbatively with the use of basis functions compatible with the external field configuration, the parabolic cylinder functions. It is found that chiral symmetry, broken by a uniform magnetic field, is restored by electric field. Obtained result is nonperturbative in nature: even the tiniest deviation of the electric field from zero restores chiral symmetry. In the second part, heavy quarkonium systems are investigated. To study these systems, a phenomenological nonrelativistic model is built. Approximate solutions to this model are found with the use of a specially designed Pade approximation and by direct numerical integration of Schrodinger equation. The results are compared with experimental measurements of respective meson masses. Good agreement between theoretical calculations and experimental results is found. Advantages and shortcommings of the new approximation method are analysed. In the third part, an extension of the standard model of elementary particles is studied. The extension, called the aspon model, was originally introduced to cure the so called strong CP problem. In addition to fulfilling its original purpose, the aspon model modifies the couplings of the standard model quarks to the Z boson. As a result, the decay rates of the Z boson to quarks are altered. By using the recent precise measurements of the decay rates Z → bb and Z /to [/it c/=c], new constraints on the aspon model parameters are found.

  11. 40 CFR 300.220 - Related Title III issues.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Related Title III issues. 300.220 Section 300.220 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY... PLAN Planning and Preparedness § 300.220 Related Title III issues. Other related Title III requirements...

  12. Nuclear power and related safety issues

    International Nuclear Information System (INIS)

    Valdezco, Eulinia M.

    2009-01-01

    There are a cluster of trends that reinforce the importance of nuclear power on the world scene. Energy is the essential underpinning for economic and societal progress and, as the developing world advances, the demand for energy is growing significantly. At the same time, the carbon-intensive sources of energy on which the world has traditionally relied - in particular, coal, oil, and natural gas - pose grave threats because the growing concentrations of carbon dioxide in the atmosphere will bring about climate and ocean acidification. At the same time, rising and volatile fossil fuel prices, coupled with concerns about the security of supplies of oil and gas, enhance interest in sources of energy that do not pose the same costs and risks. As an important part of the world's response to these threats, many countries are embarking on either new or expanded nuclear power programs, more commonly referred to as a nuclear renaissance. The construction of nuclear power plants is under consideration in over thirty countries that do not currently use nuclear power. For new entrants that may have experience in constructing and operating large-scale industrial and infrastructure projects, they may not be fully familiar with the unique requirements of nuclear power and may not be fully recognize the major commitments and understandings that they must assume. Additionally, an understanding of the full range of obligations may have diminished in those countries with only one or a few reactors and where nuclear construction has not been undertaken for a long time. It is therefore in the interest of all to ensure that every country with a nuclear power program has the resources, expertise, authority and capacity to assure safety in a complete and effective manner and is committed to doing so. This presentation will outline some of the more important national infrastructure considerations including nuclear safety issues for launching a nuclear power program. An update on the

  13. Bill project related to the struggle against the proliferation of arms of massive destruction and their vectors

    International Nuclear Information System (INIS)

    2011-01-01

    This bill project addresses several issues: the struggle against proliferation of arms of massive destruction (nuclear weapons, nuclear materials, biological weapons, and chemical weapons), the struggle against proliferation of vectors of arms of massive destruction, double-use goods, the use of these weapons and vectors in acts of terrorism

  14. High relative humidity pre-harvest reduces post-harvest proliferation of Salmonella in tomatoes.

    Science.gov (United States)

    Devleesschauwer, Brecht; Marvasi, Massimiliano; Giurcanu, Mihai C; Hochmuth, George J; Speybroeck, Niko; Havelaar, Arie H; Teplitski, Max

    2017-09-01

    Outbreaks of human illness caused by enteric pathogens such as Salmonella are increasingly linked to the consumption of fruits and vegetables. Knowledge on the factors affecting Salmonella proliferation on fresh produce therefore becomes increasingly important to safeguard public health. Previous experiments showed a limited impact of pre-harvest production practices on Salmonella proliferation on tomatoes, but suggested a significant effect of harvest time. We explored the data from two previously published and one unpublished experiment using regression trees, which allowed overcoming the interpretational difficulties of classical statistical models with higher order interactions. We assessed the effect of harvest time by explicitly modeling the climatic conditions at harvest time and by performing confirmatory laboratory experiments. Across all datasets, regression trees confirmed the dominant effect of harvest time on Salmonella proliferation, with humidity-related factors emerging as the most important underlying climatic factors. High relative humidity the week prior to harvest was consistently associated with lower Salmonella proliferation. A controlled lab experiment confirmed that tomatoes containing their native epimicrobiota supported significantly lower Salmonella proliferation when incubated at higher humidity prior to inoculation. The complex interactions between environmental conditions and the native microbiota of the tomato crop remain to be fully understood. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. NON-PROLIFERATION IMPACT ASSESSMENT FOR GNEP: ISSUES ASSOCIATED WITH TRANSPORTATION.

    Energy Technology Data Exchange (ETDEWEB)

    Radel, Ross; Rochau, Gary E

    2008-03-01

    This report evaluates transportation issues for nuclear material in the proposed Global Nuclear Energy Partnership (GNEP) fuel cycle. Since many details of the GNEP program are yet to be determined, this document is intended only to identify general issues. The existing regulatory environment is determined to be largely prepared to incorporate the changes that the GNEP program will introduce. Nuclear material vulnerability and attractiveness are considered with respect to the various transport stages within the GNEP fuel cycle. Physical protection options are then outlined for the transportation of this nuclear material. It is determined that increased transportation security will be required for the GNEP fuel cycle, particularly for international transport. Finally, transportation considerations for several fuel cycle scenarios are discussed. These scenarios compare the current "once-through" fuel cycle with various aspects of the proposed GNEP fuel cycle. 3

  16. Summary of activities on CSS related issues

    International Nuclear Information System (INIS)

    Loriaux, E.

    1996-01-01

    In the Netherlands there are two nuclear power plants. One 60Mw BWR for research purposes in Dodewaard, and one PWR 450 Mw IN Borssele. Both of these NPPs are undergoing an extensive upgrading. These plants use several CSS-like systems. These systems are primarily aimed to support and monitor safe and correct operation of the process or to detect specific (e.g. mechanical) problems in an early stage. The NPP in Dodewaard is upgrading its training simulator and process presentation system (''Datalogger''). The activities related to the CRP are mainly within the framework of the Dodewaard plant. This final national report will give an overview of these activities with particular emphasis on the replacement of the Datalogger system. Some additional information is given on trends in CSSs as used in fossil power plants. (author). 2 figs

  17. An approach to quantitative assessment of relative proliferation risks from nuclear fuel cycles

    International Nuclear Information System (INIS)

    Silvennoinen, P.; Vira, J.

    1981-01-01

    Feasibility of quantitative assessments of the risk of nuclear weapons proliferation is discussed in this paper. The proliferation risk is defined as a combined utility of the different fuel cycle processes or materials for the proscribed acquisition of a nuclear weapon. Based on a set of selected weighted criteria, the process utilities are calculated employing utility functions or fuzzy expectation values. The methods are compared to each other. The scheme appears feasible in relative comparisons while certain leeway must still be retained for political judgement. (author)

  18. On the Issue of Labor Relations Discontinuance by Staff Reduction

    Directory of Open Access Journals (Sweden)

    Sheveleva A. A.

    2012-11-01

    Full Text Available This article is devoted to consideration of issues related to the procedure of labor law contract termination by staff reduction. The author, analyzing the judicial practice, gives practical recommendations on the procedure of employment relationships discontinuance

  19. Public Relations Manager Involvement in Strategic Issue Diagnosis.

    Science.gov (United States)

    Lauzen, Martha M.

    1995-01-01

    Reports on an exploratory study that seeks to build theoretical understanding of how public relations practitioner involvement in one type of strategic organizational decision making--strategic issue diagnosis--is related to shared values with top management, diagnosis accuracy, strategy pursued, and the power of the public relations function. (TB)

  20. Exploring work-related issues on corporate sustainability.

    Science.gov (United States)

    Brunoro, C M; Bolis, I; Sznelwar, L I

    2015-01-01

    In a research project about work-related issues and corporate sustainability conducted in Brazil, the goal was to better understand how work-related issues were addressed in the corporate context. Particularly, there are some specific initiatives that serve as guides to organizational decisions, which make their performance indicators for the context of corporate sustainability. 1) To explore the presence of work-related issues and their origins in corporate sustainability approach, analyzing a) corporate disclosures; b) sustainability guidelines that are identified as relevant in corporate disclosures; c) documents that are related to sustainable development and also identified as key-documents for these guidelines and initiatives. 2) To present the activity-centered ergonomics and psychodynamics of work contributions to work-related issues in a corporate sustainability approach. An exploratory study based on multiple sources of evidence that were performed from 2012 to 2013, including interviews with companies that engaged in corporate sustainability and document analysis using the content analysis approach. Work-related issues have been presented since the earliest sustainable development documents. It is feasible to construct an empirical framework for work-related issues and corporate sustainability approaches. 1) Although some authors argue that corporate sustainability has its roots based only on the environmental dimension, there is strong empirical evidence showing that social dimension aspects such as work-related issues have been present since the beginning. 2) Some indicators should be redesigned to more precisely translate the reality of some workplaces, particularly those indicators related to organizational design and mental health.

  1. JPRS Report, Proliferation Issues

    Science.gov (United States)

    1992-12-11

    with the U.S. on the elimination of nuclear weapons be used to produce weapons. Great Britain and Kaz- deployed in the republic. Konstantin Grishenko ...cooperation and partnership. missiles would be sold to the American side. That is why, said Grishenko , Washington believes that the transfer of Observers

  2. JPRS Report, Proliferation Issues

    Science.gov (United States)

    1992-05-27

    every kind to all such activities. It is a public-sector institution of a scientific, technical, and industrial character, legally incorporated and...reactors’ radioactive waste and to subsequently entomb it in special deposito - ries. But this way of eliminating this expensive substance is inexpedient...Edition p 6 [Article by Vladimir Trofimov, candidate of Historical Sciences of the Russian Foreign Ministry Legal Depart- ment under the "Opinion" rubric

  3. JPRS Report, Proliferation Issues

    Science.gov (United States)

    1992-05-20

    accepted, Research Organisation’s (ISRO) Polar Satellite Launch according to defence analysts here. Vehicle (PSLV) has been planned at Balasore in Orissa...the slightest of ISRO’s Balasore satellite launch station. The figure is sensitivity to Indian security needs and concerns, the same as last year. JPRS

  4. JPRS Report Proliferation Issues

    National Research Council Canada - National Science Library

    1991-01-01

    ... and the transfer of weapons relevant technologies. The following locations are included: (1) China; (2) Indonesia; (3) Bulgaria; (4) Brazil, Cuba; (5) Egypt, India, Iran, Iraq, Israel, Pakistan...

  5. JPRS Report Proliferation Issues

    Science.gov (United States)

    1991-10-29

    MVLIS) which utilizes carbon dioxide lasers. such an experience in the United States or Europe. They were able to go into uranium enrichment and repro...yttrium, is used like phosphorous in color television Rhodia, Paranapanema, the Belgian Solvay group, and sets. By combining samarium with neodymium, two...use presently. There have been some using thorium and U-233. problems centering on the liquid sodium coolant used in FBTR reportedly accentuated by use

  6. JPRS Report, Proliferation Issues

    Science.gov (United States)

    1992-06-25

    control of INGTON POST saying: "Secretary of Defense Richard Nuclemon Minero Quimica Ltda. [Nuclebras Monazite and Cheney approved the Pentagon’s plan ... Planned [Alm a-Ata Radio] .................................................................................................. 26 Krasnoyarsk Search for...34 [Article by political staff: "Space plan defended"] He said the aim of the investigation was to determine the market opportunities, risks and

  7. JPRS Report, Proliferation Issues

    Science.gov (United States)

    1993-03-22

    delivering abroad polonium sources (with experimental physics. polonium - 210 radioisotopes) for several decades now. They are mostly used in space...34sensations"-from attempts to steal pre- gorod a short while ago. It claimed that the load con- cious and rare-earth metals to food stocks which have

  8. JPRS Report, Proliferation Issues

    Science.gov (United States)

    1992-10-21

    Russia, India, Cuba, Ukraine, and countries in the Asian Defence Minister Najib Razak said Friday Japan should Pacific region, the Dalat Nuclear Research...34 he told reporters. tion of natural resources and minerals; agricultural, industrial, and export production; and to the work of Najib was commenting

  9. Preventing proliferation

    International Nuclear Information System (INIS)

    Rathjens, G.

    1983-01-01

    Challenging the argument that nuclear proliferation may be stabilizing, the author cites the Israeli attack on Iraq as evidence that emergent nuclear states may be moved to attack their adversaries.The larger the number of decision makers who can unleash nuclear weapons, the greater the liklihood of their use. Several reasons are cited for nations to seek nuclear capability: the accelerated spread of technology, the deterioration in US-Soviet relations and strength relative to their nations, the high cost of conventional weapons, and a loss of confidence in the international safeguards system. The imposition of constraints, such as a Comprehensive Test Ban Treaty, on nuclear trade and technology transfer are likely to have a high cost. The US position on this issue is likely to be determined by the balance of power with the Soviet Union. 5 references

  10. Modulating Estrogen Receptor-related Receptor-α Activity Inhibits Cell Proliferation*

    Science.gov (United States)

    Bianco, Stéphanie; Lanvin, Olivia; Tribollet, Violaine; Macari, Claire; North, Sophie; Vanacker, Jean-Marc

    2009-01-01

    High expression of the estrogen receptor-related receptor (ERR)-α in human tumors is correlated to a poor prognosis, suggesting an involvement of the receptor in cell proliferation. In this study, we show that a synthetic compound (XCT790) that modulates the activity of ERRα reduces the proliferation of various cell lines and blocks the G1/S transition of the cell cycle in an ERRα-dependent manner. XCT790 induces, in a p53-independent manner, the expression of the cell cycle inhibitor p21waf/cip1 at the protein, mRNA, and promoter level, leading to an accumulation of hypophosphorylated Rb. Finally, XCT790 reduces cell tumorigenicity in Nude mice. PMID:19546226

  11. 76 FR 63573 - Roundtable on Issues Relating to Conflict Minerals

    Science.gov (United States)

    2011-10-13

    ...-10] Roundtable on Issues Relating to Conflict Minerals AGENCY: Securities and Exchange Commission... Consumer Protection Act (the ``Act''), which relates to reporting requirements regarding conflict minerals... of conflict minerals from the Democratic Republic of the Congo and adjoining countries. On December...

  12. Social justice issues related to uneven distribution of resources.

    Science.gov (United States)

    Ervin, Naomi E; Bell, Sue Ellen

    2004-01-01

    This article examines the social justice issues resulting from the uneven distribution of resources. In this article, justice theories are discussed in relation to two of these issues: lack of adequate food and shelter and inequitable access to an appropriate continuum of health care. Public health nurses have the obligation to deal with the results of poverty and the uneven distribution of resources, which pose a threat to the common good in the United States and throughout the global community.

  13. Law bill relative to the fight against the proliferation of weapons of mass destruction and of their vectors

    International Nuclear Information System (INIS)

    2009-05-01

    The existing French legislation about the prevention and repression of proliferation actions is complex and includes some loopholes in some particular proliferation-related situations. Therefore, this bill aims at improving this situation by reinforcing the efficiency, the consistency and the dissuasive nature of the French legislation in this domain. (J.S.)

  14. Luteolin suppresses cancer cell proliferation by targeting vaccinia-related kinase 1.

    Directory of Open Access Journals (Sweden)

    Ye Seul Kim

    Full Text Available Uncontrolled proliferation, a major feature of cancer cells, is often triggered by the malfunction of cell cycle regulators such as protein kinases. Recently, cell cycle-related protein kinases have become attractive targets for anti-cancer therapy, because they play fundamental roles in cellular proliferation. However, the protein kinase-targeted drugs that have been developed so far do not show impressive clinical results and also display severe side effects; therefore, there is undoubtedly a need to investigate new drugs targeting other protein kinases that are critical in cell cycle progression. Vaccinia-related kinase 1 (VRK1 is a mitotic kinase that functions in cell cycle regulation by phosphorylating cell cycle-related substrates such as barrier-to-autointegration factor (BAF, histone H3, and the cAMP response element (CRE-binding protein (CREB. In our study, we identified luteolin as the inhibitor of VRK1 by screening a small-molecule natural compound library. Here, we evaluated the efficacy of luteolin as a VRK1-targeted inhibitor for developing an effective anti-cancer strategy. We confirmed that luteolin significantly reduces VRK1-mediated phosphorylation of the cell cycle-related substrates BAF and histone H3, and directly interacts with the catalytic domain of VRK1. In addition, luteolin regulates cell cycle progression by modulating VRK1 activity, leading to the suppression of cancer cell proliferation and the induction of apoptosis. Therefore, our study suggests that luteolin-induced VRK1 inhibition may contribute to establish a novel cell cycle-targeted strategy for anti-cancer therapy.

  15. U.S.-Mexico Economic Relations: Trends, Issues, and Implications

    Science.gov (United States)

    2012-01-25

    Time,” Economia , Fall 2003. 49 Esquivel, Gerardo, and José Antonio Rodríguez-López, “Technology, trade, and wage inequality in Mexico before and after...CRS Report for Congress Prepared for Members and Committees of Congress U.S.- Mexico Economic Relations: Trends, Issues, and Implications...25 JAN 2012 2. REPORT TYPE 3. DATES COVERED 00-00-2012 to 00-00-2012 4. TITLE AND SUBTITLE U.S.- Mexico Economic Relations: Trends, Issues, and

  16. The legal points at issue concerning the Non-proliferation Treaty and the verification agreement of EURATOM with the IAEA

    International Nuclear Information System (INIS)

    Zieger, G.

    1975-01-01

    An excellent and comprehensive but very juridicial contribution on: Development and content of the Non-proliferation Treaty, the problems which this Treaty poses for EURATOM (a common market, common supply, joint enterprises, Non-proliferation Treaty and France), the compatibility of the Non-proliferation Treaty with the EURATOM Treaty, verification agreement EURATOM - IAEA (the IAEA as the supervisory authority, the control system of the IAEA, guidelines elaborated by the IAEA to be used as the basis for negotiating safeguard agreements, national systems of accounting for and control of nuclear material IAEA supervision as a secondary control, principles of IAEA supervision, secrecy, conflict management), conclusion of the verification agreement, deviations from the guidelines elaborated by the IAEA to be used as the basis for negotiating safeguard agreements legal reflexions (verification agreement and Non-proliferation Treaty, reservations concerning the Non-proliferation Treaty, questions of competence between EURATOM and member states without nuclear weapons, problems of equal treatment). (HP/LN) [de

  17. Issues related to EM management of DOE spent nuclear fuel

    International Nuclear Information System (INIS)

    Abbott, D.G.; Abashian, M.S.; Chakraborti, S.; Roberson, K.; Meloin, J.M.

    1993-07-01

    This document is a summary of the important issues involved in managing spent nuclear fuel (SNF) owned by the Department of Energy (DOE). Issues related to civilian SNF activities are not discussed. DOE-owned SNF is stored primarily at the Hanford Site, Idaho National Engineering Laboratory (INEL), Savannah River Site (SRS), Oak Ridge National Laboratory (ORNL), and West Valley Demonstration Project. Smaller quantities of SNF are stored at Brookhaven National Laboratory, Sandia National Laboratories, and Los Alamos National Laboratory (LANL). There is a wide variety of fuel types, including both low and high enrichment fuels from weapons production, DOE reactors, research and development programs, naval programs, and universities. Most fuel is stored in pools associated with reactor or reprocessing facilities. Smaller quantities are in dry storage. Physical conditions of the fuel range from excellent to poor or severely damaged. An issue is defined as an important question that must be answered or decision that must be made on a topic or subject relevant to achieving the complimentary objectives of (a) storing SNF in compliance with applicable regulations and orders until it can be disposed, and (b) safely disposing of DOE's SNF. The purpose of this document is to define the issues; no recommendations are made on resolutions. As DOE's national SNF management program is implemented, a system of issues identification, documentation, tracking, and resolution will be implemented. This document is an initial effort at issues identification. The first section of this document is an overview of issues that are common to several or all DOE facilities that manage SNF. The common issues are organized according to specific aspects of spent fuel management. This is followed by discussions of management issues that apply specifically to individual DOE facilities. The last section provides literature references

  18. Issues related to the inter-utility transfer of material

    International Nuclear Information System (INIS)

    1993-08-01

    An option that utilities have for obtaining material is to procure the desired item(s) from another utility. There are several reasons utilities choose another utility as the procurement source including item obsolescence, prohibitive cost on the commercial market, and excessive lead time. This document provides information on the technical, quality, and commercial issues which utilities may need to address when selling material to or procuring material from other utilities. This report provides suggested approaches for each of the following technical and quality issues: Design considerations; item acceptability considerations; original supplier considerations; commercial grade item dedication considerations; reportability considerations; packaging, shipping, and storage considerations; documentation considerations; receipt inspection considerations. The information is provided primarily for the inter-utility transfer of safety-related material. Several of the topics, however, may also apply to the transfer of non-safety-related material. The report also provides considerations on commercial issues which may be addressed during the inter-utility transfer of materials

  19. Attachment-related mental representations: introduction to the special issue.

    Science.gov (United States)

    Thompson, Ross A

    2008-12-01

    Bowlby's concept of mental working models of self, attachment figures, and the social world has been theoretically generative as a bridge between early relational experience and the beliefs and expectations that color later relationships. Contemporary attachment researchers, following his example, are applying new knowledge of children's conceptual development to their study of attachment-related mental representations in children and adults. The contributors to this special issue highlight recent advances in how the mental representations arising from attachment security should be conceptualized and studied, and identify a number of important directions for future work. This paper introduces the special issue by summarizing the major ideas of Bowlby and his followers concerning the nature and development of mental working models, points of theoretical clarity and uncertainty, and challenges in assessing these representations, as well as profiling each of the contributions to this issue.

  20. Bill project related to the struggle against the proliferation of arms of massive destruction and their vectors; Projet de Loi relatif a la lutte contre la proliferation des armes de destruction massive et de leurs vecteurs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    This bill project addresses several issues: the struggle against proliferation of arms of massive destruction (nuclear weapons, nuclear materials, biological weapons, and chemical weapons), the struggle against proliferation of vectors of arms of massive destruction, double-use goods, the use of these weapons and vectors in acts of terrorism

  1. An exploration of issues relating to feminism and nurse education.

    Science.gov (United States)

    Millar, B; Biley, F C

    1992-08-01

    This paper explores the issue of feminism in relation to nursing and nurse education. As a result of this exploration, the authors suggest there is a need for a move away from traditional patriarchal approaches to nurse education, towards an educational programme based on empowerment principles that maximises the potential of feminine patterns of thinking.

  2. Ethical issues in trauma-related research: a review.

    Science.gov (United States)

    Newman, Elana; Risch, Elizabeth; Kassam-Adams, Nancy

    2006-09-01

    ETHICAL DECISION-MAKING ABOUT TRAUMA-RELATED STUDIES requires a flexible approach that counters assumptions and biases about victims, assures a favorable ethical cost-benefit ratio, and promotes advancement of knowledge that can benefit survivors of traumatic stress. This paper reviews several ethical issues in the field of traumatic stress: benefit and risks in trauma-related research, whether trauma-related research poses unique risks and if so what those might be, informed consent and mandatory reporting, and supervision of trauma-related research. For each topic, we review potential ethical issues, summarize the research conducted thus far to inform ethical practice, and recommend future practice, research questions and policies to advance the field so that research on trauma can continue to be a win-win situation for all stakeholders in the research enterprise.

  3. Issues relating to airborne applications of HTS SQUIDs

    CERN Document Server

    Foley, C P; Binks, R A; Lam, S H K; Du, J; Tilbrook, D L; Mitchell, E E; MacFarlane, J C; Lee, J B; Turner, R; Downey, M; Maddever, A

    2002-01-01

    Airborne application of HTS SQUIDs is the most difficult environment for their successful deployment. In order to operate with the sensitivity required for a particular application, there are many issues to be addressed such as the need for very wide dynamic range electronics, motion noise elimination, immunity to large changing magnetic fields and cultural noise sources. This paper reviews what is necessary to achieve an airborne system giving examples in geophysical mineral exploration. It will consider issues relating to device design and fabrication, electronics, dewar design, suspension system requirements and noise elimination methods.

  4. Issues relating to airborne applications of HTS SQUIDs

    International Nuclear Information System (INIS)

    Foley, C P; Leslie, K E; Binks, R A; Lam, S H K; Du, J; Tilbrook, D L; Mitchell, E E; Macfarlane, J C; Lee, J B; Turner, R; Downey, M; Maddever, A

    2002-01-01

    Airborne application of HTS SQUIDs is the most difficult environment for their successful deployment. In order to operate with the sensitivity required for a particular application, there are many issues to be addressed such as the need for very wide dynamic range electronics, motion noise elimination, immunity to large changing magnetic fields and cultural noise sources. This paper reviews what is necessary to achieve an airborne system giving examples in geophysical mineral exploration. It will consider issues relating to device design and fabrication, electronics, dewar design, suspension system requirements and noise elimination methods

  5. Holdup-related issues in safeguarding of nuclear materials

    International Nuclear Information System (INIS)

    Pillay, K.K.S.

    1988-03-01

    Residual inventories of special nuclear materials (SNM) remaining in processing facilities (holdup) are recognized as an insidious problem for both safety and safeguards. This paper identifies some of the issues that are of concern to the safeguards community at-large that are related to holdup of SNM in large-scale process equipment. These issues range from basic technologies of SNM production to changing regulatory requirements to meet the needs of safeguarding nuclear materials. Although there are no magic formulas to resolve these issues, there are several initiatives that could be taken in areas of facility design, plant operation, personnel training, SNM monitoring, and regulatory guidelines to minimize the problems of holdup and thereby improve both safety and safeguards at nuclear material processing plants. 8 refs

  6. Trade-related Electronic Commerce Issues in the OECD

    Directory of Open Access Journals (Sweden)

    Chang-In Yoon

    1998-12-01

    Full Text Available The trade committee of Organization for Economic Cooperation and Development (OECD has begun the study of the trade related to electronic commerce since 1997. The scale of the study on one hand has avoided the fact of copy and duplication of WTO and its organizational principles, on the other hand it has played a supplementary and supportive function. At present, digital-related product, such as computers, software and travel is the key point to the trade which resorts to electronic commerce. It is predicted that this trend will go on. The study on electronic commerce could be summed up into three main components: First, according to the phase of the trade, it could be divided into advertisement, purchase, delivery and payment. Second, issues on electronic commerce in the international trade; such as the issue that leads to the unfairness and non-neutrality of the searching engine in international service trade. Besides, domain name, trademarks and the issue of middleman which exist at the moment in the electronic commerce are activated and will also be discussed. Third, issues of the trade policy related to the electronic commerce. For instance, the kernel principles which support the multi-trade regulation, including transparency, indiscrimination, anti-dumping, flexible trade, government arrangement, tariff and competition policy and so on. Under this background, we should explore way in formulating hypotheses with preconceived issues, validating the electronic commerce trade on the spot, actualizing the study on the application of electronic commerce coming with the GATS regulation, seeking the countermeasure in the future trade policy, such as benefit policy to the electronic commerce department and electronic commerce strategy approach of certain enterprises, etc.

  7. Assistance to States on Policies Related to Wind Energy Issues

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Matthew, H; Decesaro, Jennifer; DOE Project Officer - Keith Bennett

    2005-07-15

    This final report summarizes work carried out under agreement with the US Department of Energy, related to wind energy policy issues. This project has involved a combination of outreach and publications on wind energy, with a specific focus on educating state-level policymakers. Education of state policymakers is vitally important because state policy (in the form of incentives or regulation) is a crucial part of the success of wind energy. State policymakers wield a significant influence over all of these policies. They are also in need of high quality, non-biased educational resources which this project provided. This project provided outreach to legislatures, in the form of meetings designed specifically for state legislators and legislative staff, responses to information requests on wind energy, and publications. The publications addressed: renewable energy portfolio standards, wind energy transmission, wind energy siting, case studies of wind energy policy, avian issues, economic development, and other related issues. These publications were distributed to legislative energy committee members, and chairs, legislative staff, legislative libraries, and other related state officials. The effect of this effort has been to provide an extensive resource of information about wind information for state policymakers in a form that is useful to them. This non-partisan information has been used as state policymakers attempt to develop their own policy proposals related to wind energy in the states.

  8. Legal issues relating to the Ontario FIT contract - An update

    International Nuclear Information System (INIS)

    Weizman, Michael

    2011-01-01

    The paper discusses the legal issues related to the Ontario FIT contract, which includes the FIT waiver agreement, WTO challenge, FIT extension, political risk assessment and issues related to unforeseen events beyond human control (force majeure). The risk of termination of the FIT waiver is omitted for convenience by OPA but timing implications relating to the FIT waiver are included. The binding agreement for supply of generating equipment is also presented and the term sheet for turbine equipment and bill of purchase being understood as binding agreements is questioned. Political risks relate to existing contracts, lawsuit risks and changes to the REA process. Change in government and the implications of minority government can be added to the political risks. A successful WTO challenge has been assumed and the possible implications are discussed. Some of them include risk to FIT contracts already issued; changes in DC requirements and in FIT contract pricing and re-pricing of construction and turbine equipment supply contracts if DC requirements are relaxed.

  9. Proliferation related acidic leucine-rich protein PAL31 functions as a caspase-3 inhibitor

    International Nuclear Information System (INIS)

    Sun Weiyong; Kimura, Hiromichi; Hattori, Naka; Tanaka, Satoshi; Matsuyama, Shigemi; Shiota, Kunio

    2006-01-01

    Proliferation related acidic leucine-rich protein PAL31 (PAL31) is expressed in proliferating cells and consists of 272 amino acids with a tandem structure of leucine-rich repeats in the N-terminus and a highly acidic region with a putative nuclear localization signal in the C-terminus. We previously reported that PAL31 is required for cell cycle progression. In the present study, we found that the antisense oligonucleotide of PAL31 induced apoptosis to the transfected Nb2 cells. Stable transfectants, in which PAL31 was regulated by an inducible promoter, were generated to gain further insight into the signaling role of PAL31 in the regulation of apoptosis. Expression of PAL31 resulted in the marked rescue of Rat1 cells from etoposide and UV radiation-induced apoptosis and the cytoprotection was correlated with the levels of PAL31 protein. Thus, cytoprotection from apoptosis is a physiological function of PAL31. PAL31 can suppress caspase-3 activity but not cytochrome c release in vitro, indicating that PAL31 is a direct caspase-3 inhibitor. In conclusion, PAL31 is a multifunctional protein working as a cell cycle progression factor as well as a cell survival factor

  10. Issues related to development of Indian photovoltaic market

    International Nuclear Information System (INIS)

    Chaurey, A.; Laxminarayan, R.

    1993-01-01

    As is the case of most energy deficient countries in the tropics, India offers an enormous potential for use of photovoltaic (PV) systems. However, the demand in true commercial sense has not yet been created. The constraints for market development are not only related to the cost but also to several local parameters. The paper highlights these issues and constraints and suggests a market development strategy. (author)

  11. The united fund of materials about Chernobyl-related issues

    International Nuclear Information System (INIS)

    Bashilov, A. V.; Borisevich, N.Ya.; Sobolev, O.V.

    2013-01-01

    The United Fund of materials about Chernobyl-related issues was created in Russian-Belarusian Information Center on the Problems of the Consequences of the Catastrophe at Chernobyl NPP branch RSRUE 'Institute of Radiology' Ministry for Emergency Situations of the Republic of Belarus. It contains accumulated during the post-Chernobyl period systematized maps, scientific and practical, educational, documentary, journalistic, artistic, photographic and other information. (authors)

  12. Japan-U.S. Relations: Issues for Congress

    Science.gov (United States)

    2013-02-15

    China called for a boycott on Japanese goods and defaced Japanese retail stores. Japanese auto manufacturers experienced sharp declines in sales in...TPP is now an agreement under negotiation among the original four countries plus the United States, Australia, Canada, Mexico, Peru, Malaysia , and...Inside U.S. Trade, April 27, 2012. 44 World Trade Online , April 5, 2012. Japan-U.S. Relations: Issues for Congress Congressional Research Service 25

  13. Environmentally related taxes in OECD countries: issues and strategies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    Economic instruments, including environmentally related taxes, play an increasing role in the environmental policies of developed countries. This publication addresses the use of environmental taxes and their effectiveness in reducing environmental damage. It finds these taxes are a powerful tool for implementing environmental strategy. It also describes obstacles to increased use of such taxes (e.g. concerns about competitiveness and distributional effects) and suggests ways to overcome such barriers. Particular attention is given to issues and options related to taxes on greenhouse gases. 18 figs., 13 tabs.

  14. Current safety issues related to research reactor operation

    International Nuclear Information System (INIS)

    Alcala-Ruiz, F.

    2000-01-01

    The Agency has included activities on research reactor safety in its Programme and Budget (P and B) since its inception in 1957. Since then, these activities have traditionally been oriented to fulfil the Agency's functions and obligations. At the end of the decade of the eighties, the Agency's Research Reactor Safety Programme (RRSP) consisted of a limited number of tasks related to the preparation of safety related publications and the conduct of safety missions to research reactor facilities. It was at the beginning of the nineties when the RRSP was upgraded and expanded as a subprogramme of the Agency's P and B. This subprogramme continued including activities related to the above subjects and started addressing an increasing number of issues related to the current situation of research reactors (in operation and shut down) around the world such as reactor ageing, modifications and decommissioning. The present paper discusses some of the above issues as recognised by various external review or advisory groups (e.g., Peer Review Groups under the Agency's Performance Programme Appraisal System (PPAS) or the standing International Nuclear Safety Advisory Group (INSAG)) and the impact of their recommendations on the preparation and implementation of the part of the Agency's P and B relating to the above subject. (author)

  15. Mixing of immiscible fluids in chaotic flows and related issues

    International Nuclear Information System (INIS)

    Ottino, J.M.

    1993-01-01

    The basis goal of this work was to obtain a basic understanding of mixing of immiscible fluids leading to the determination of flow conditions which result in efficient breakup and dispersion of one mass of fluid in the bulk of another. Related issues were the prediction of the morphological structures and drop size distribution for a given set of operating conditions. The primary motivation for these investigations was to produce basic knowledge leading to increased understanding of industrial processes involving blending, agitation, emulsification, and dissolution

  16. A Research on Issues Related to RFID Security and Privacy

    Science.gov (United States)

    Kim, Jongki; Yang, Chao; Jeon, Jinhwan

    Radio Frequency Identification (RFID) is a technology for automated identification of objects and people. RFID systems have been gaining more popularity in areas especially in supply chain management and automated identification systems. However, there are many existing and potential problems in the RFID systems which could threat the technology's future. To successfully adopt RFID technology in various applications, we need to develop the solutions to protect the RFID system's data information. This study investigates important issues related to privacy and security of RFID based on the recent literature and suggests solutions to cope with the problem.

  17. Codes of practice and related issues in biomedical waste management

    Energy Technology Data Exchange (ETDEWEB)

    Moy, D.; Watt, C. [Griffith Univ. (Australia)

    1996-12-31

    This paper outlines the development of a National Code of Practice for biomedical waste management in Australia. The 10 key areas addressed by the code are industry mission statement; uniform terms and definitions; community relations - public perceptions and right to know; generation, source separation, and handling; storage requirements; transportation; treatment and disposal; disposal of solid and liquid residues and air emissions; occupational health and safety; staff awareness and education. A comparison with other industry codes in Australia is made. A list of outstanding issues is also provided; these include the development of standard containers, treatment effectiveness, and reusable sharps containers.

  18. High relative humidity pre-harvest reduces post-harvest proliferation of Salmonella in tomatoes

    NARCIS (Netherlands)

    Devleesschauwer, Brecht; Marvasi, Massimiliano; Giurcanu, Mihai C.; Hochmuth, George J.; Speybroeck, Niko; Havelaar, Arie H.; Teplitski, Max

    2017-01-01

    Outbreaks of human illness caused by enteric pathogens such as Salmonella are increasingly linked to the consumption of fruits and vegetables. Knowledge on the factors affecting Salmonella proliferation on fresh produce therefore becomes increasingly important to safeguard public health. Previous

  19. III-V nanoelectronics and related surface/interface issues

    International Nuclear Information System (INIS)

    Hasegawa, Hideki

    2003-01-01

    The conventional logic gate architecture is not suitable for high-density integration of quantum devices which are non-robust and extremely structure- and charge-sensitive. In this paper, our novel hexagonal binary-decision-diagram (BDD) quantum circuit approach for III-V nanoelectronics is reviewed and related critical surface/interface issues for high-density integration are discussed. First, the basic concept and actual implementation method of our approach are explained, giving examples of novel BDD quantum integrated circuits where nanowire networks are controlled by nanoscale Schottky wrap gates. For high-density integration, growth of embedded sub-10 nm III-V quantum wire networks by selective molecular beam epitaxy (MBE) on patterned substrates is described, including effects of atomic hydrogen irradiation and kinetic control of wire width. The key processing issue lies in understanding and control of nanostructure surfaces/interfaces. Behavior of nanoscale Schottky gates, recent scanning tunneling microscopy (STM)/scanning tunneling spectroscopy (STS) studies of surface states, and successful removal of surface states by MBE-grown silicon interface control layer are discussed

  20. Ethical issues related to epilepsy care in the developing world.

    Science.gov (United States)

    Tan, Chong-Tin; Avanzini, Giuliano

    2009-05-01

    There are three major issues of ethical concern related to epilepsy care in the developing world. First, is it ethical for a developing country to channel its limited resources from direct epilepsy care to research? The main considerations in addressing this question are the particular research questions to be addressed and whether such research will bring direct benefits to the local community. Second, in a country with limited resources, when does ignoring the high treatment gap become an ethical issue? This question is of particular concern when the community has enough resources to afford treatment for its poor, yet is not providing such care because of gross wastage and misallocation of the national resources. Third, do countries with plentiful resources have an ethical responsibility to help relieve the high epilepsy treatment gap of poor countries? Indeed, we believe that reasonable health care is a basic human right, and that human rights transcend national boundaries. Although health care is usually the responsibility of the nation-state, many modern states in the developing world are arbitrary creations of colonization. There is often a long process from the establishment of a political-legal state to a mature functional nation. During the long process of nation building, help from neighboring countries is often required.

  1. Kurdish men's experiences of migration-related mental health issues.

    Science.gov (United States)

    Taloyan, Marina; Al-Windi, Ahmad; Johansson, Leena Maria; Saleh-Stattin, Nuha

    2011-10-01

    The migration process may impose stress on the mental health of immigrants. To describe the experiences of immigrant men of Kurdish ethnicity during and after migration to Sweden with regard to mental health issues. Using the grounded theory method, we conducted a focus group interview with four Kurdish men and in-depth individual interviews with 10 other Kurdish men. A model with two major themes and interlinked categories was developed. The themes were (1) protective factors for good mental health (sense of belonging, creation and re-creation of Kurdish identity, sense of freedom, satisfaction with oneself) and (2) risk factors for poor mental health (worry about current political situation in the home country, yearning, lack of sense of freedom, dissatisfaction with Swedish society). The study provides insights into the psychological and emotional experiences of immigrant men of Kurdish ethnicity during and after migration to Sweden. It is important for primary health care providers to be aware of the impact that similar migration-related and life experiences have on the health status of immigrants, and also to be aware that groups are comprised of unique individuals with differing experiences and reactions to these experiences. The findings highlight the common themes of the men's experiences and suggest ways to ameliorate mental health issues, including feeling like one is seen as an individual, is a full participant in society, and can contribute to one's own culture.

  2. Law bill relative to the fight against the proliferation of weapons of mass destruction and of their vectors; Projet de loi relatif a la lutte contre la proliferation des armes de destruction massive et de leurs vecteurs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-05-15

    The existing French legislation about the prevention and repression of proliferation actions is complex and includes some loopholes in some particular proliferation-related situations. Therefore, this bill aims at improving this situation by reinforcing the efficiency, the consistency and the dissuasive nature of the French legislation in this domain. (J.S.)

  3. Safety issues relating to the design of fusion power facilities

    International Nuclear Information System (INIS)

    Stasko, R.R.; Wong, K.Y.; Russell, S.B.

    1986-06-01

    In order to make fusion power a viable future source of energy, it will be necessary to ensure that the cost of power for fusion electric generation is competitive with advanced fission concepts. In addition, fusion power will have to live up to its original promise of being a more radiologically benign technology than fission, and be able to demonstrate excellent operational safety performance. These two requirements are interrelated, since the selection of an appropriate safety philosophy early in the design phase could greatly reduce or eliminate the capital costs of elaborate safety related and protective sytems. This paper will briefly overview a few of the key safety issues presently recognized as critical to the ultimate achievement of licensable, environmentally safe and socially acceptable fusion power facilities. 12 refs

  4. Effect of splenectomy on liver cirrhosis and related surgical issues

    Directory of Open Access Journals (Sweden)

    KONG Degang

    2016-12-01

    Full Text Available Patients with liver fibrosis and cirrhosis experience certain changes in spleen morphology and function, and there is always a controversy over whether to perform splenectomy in patients with liver cirrhosis. As a surgical treatment of recurrent portal hypertension complicated by esophagogastric variceal bleeding, splenectomy can reduce portal venous pressure, reduce the possibility of gastrointestinal bleeding, and correct the reduced white blood cell count and platelet count. It can also protect the liver by improving liver function, promoting regeneration of hepatocytes, and inhibiting the progression of liver fibrosis. With reference to available clinical and laboratory data, this article reviews the effect of splenectomy on the cirrhotic liver and related issues such as selection of surgical procedures and prevention and treatment of postoperative complications, in order to promote splenectomy in patients with liver cirrhosis.

  5. [Physiological changes and related nursing care issues during hunger strike].

    Science.gov (United States)

    Hsieh, Yeu-Shan; Chen, Shiu-Lien

    2005-08-01

    The use of hunger strike as a tool to assert grievances has been around for ages and has occasionally happened in the world. Hunger strikers' motives may differ, but their tool is the same--the voluntary refusal of food. Fasting not only results in body weight loss, but also in physiological and neurological function changes, and, of course, it may even threaten life. The health care of hunger strikers is complex. It involves medical staff, medical ethics and guidance for the management of the hunger strikers. Improper medical management may not only undermine the hunger striker's dignity but also risk further damage to his or her health. By understanding hunger strikers' physiological changes and related ethical issues, therefore, we aim to identify appropriate forms of nursing care management and guidance for the care of hunger strikers.

  6. Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks

    NARCIS (Netherlands)

    Rietjens, I.M.C.M.; Sotoca, A.M.; Vervoort, J.; Louisse, J.

    2013-01-01

    Isoflavones are phytoestrogens that have been linked to both beneficial as well as adverse effects in relation to cell proliferation and cancer risks. The present article presents an overview of these seemingly contradicting health effects and of mechanisms that could be involved in this dualistic

  7. Interleukin-1β-induced autophagy-related gene 5 regulates proliferation of embryonic stem cell-derived odontoblastic cells.

    Directory of Open Access Journals (Sweden)

    Nobuaki Ozeki

    Full Text Available We previously established a method for the differentiation of induced pluripotent stem cells and embryonic stem cells into α2 integrin-positive odontoblast-like cells. We also reported that Wnt5 in response to interleukin (IL-1β induces matrix metalloproteinase (MMP-3-regulated cell proliferation in these cells. Our findings suggest that MMP-3 plays a potentially unique physiological role in the generation of odontoblast-like cells under an inflammatory state. Here, we examined whether up-regulation of autophagy-related gene (Atg 5 by IL-1β was mediated by Wnt5 signaling, thus leading to increased proliferation of odontoblast-like cells. IL-1β increased the mRNA and protein levels of Atg5, microtubule-associated protein 1 light chain (LC3, a mammalian homolog of yeast Atg8 and Atg12. Treatment with siRNAs against Atg5, but not LC3 and Atg12, suppressed the IL-1β-induced increase in MMP-3 expression and cell proliferation. Our siRNA analyses combined with western blot analysis revealed a unique sequential cascade involving Atg5, Wnt5a and MMP-3, which resulted in the potent increase in odontoblastic cell proliferation. These results demonstrate the unique involvement of Atg5 in IL-1β-induced proliferation of embryonic stem cell-derived odontoblast-like cells.

  8. Issues related to a programme of activities under the CDM

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, J.

    2006-05-15

    Emissions of CO2 from the energy and land-use change and forestry sectors are responsible for the majority of emissions in non-Annex I Parties to the UNFCCC. Tackling greenhouse gas (GHG) emissions from these sectors is a key to slowing the growth in GHG emissions in non-Annex I countries. Implementing Clean Development Mechanism (CDM) projects can help achieve this aim, while also assisting non-Annex I countries to move towards sustainable development and Annex I countries achieve their emission commitments under the Kyoto Protocol. There has been rapid progress in the CDM over the last year - in terms of the number of projects in the pipeline and registered, and in terms of credits issued. However, some important sectors are notable by their small share in the CDM portfolio. Several countries have also called attention to the need to accelerate the process of approving CDM methodologies and projects. In order to improve the effectiveness of the CDM to achieve its dual objectives, the COP/MOP agreed a decision on 'further guidance relating to the clean development mechanism. This decision lays out guidance on how to improve the operation of the CDM, and includes provisions that allow: (1) Bundling of project activities; and (2) Project activities under a programme of activities, to be registered as a CDM project activity. At present, of the 172 currently registered CDM project activities, 27 involve programmes or bundles. These project activities can include more than one project type, be implemented in several locations, and/or occur in more than one sector. This paper assesses how project activities under a programme of activities under the CDM (referred to here as PCDM) could help to increase the effectiveness of the CDM by encouraging a wide spread of emission mitigation activities. This paper also explores the key issues that may need to be considered for the PCDM concept to be further implemented. The paper concludes that: (1) Key concepts and issues

  9. Patterns of proliferation related to vasculature in human head-and-neck carcinomas before and after transplantation in nude mice

    International Nuclear Information System (INIS)

    Wijffels, Karien I.E.M.; Kaanders, Johannes H.A.M.; Marres, Henri A.M.; Bussink, Johan; Peters, Hans P.W.; Rijken, Paulus F.J.W.; Hoogen, Frank J.A. van den; Wilde, Peter C.M. de; Kogel, Albert J. van der

    2001-01-01

    Purpose: The predictive potential of tumor cell kinetic parameters may be improved when they are studied in relation to other microenvironmental parameters. The purpose of this investigation was to quantitatively categorize human tumor samples according to proliferation patterns. Second, it was examined whether these characteristics are retained after xenotransplantation. Methods and Materials: Fifty tumor samples from head-and-neck cancer patients were immunohistochemically stained for Ki-67 and vessels. Also, parts of the samples were transplanted into nude mice. Tumors were categorized according to previously described patterns of proliferation. Vascular and proliferation patterns were analyzed using an image processing system. Results: The 50 tumors were categorized into four patterns of proliferation by visual assessment: marginal (6), intermediate (10), random (21), and mixed (12). One tumor could not be classified. These patterns were quantified by calculating the Ki-67 labeling index in distinct zones at increasing distance from vessels yielding good discrimination and significant differences between patterns. The probability of growth after xenotransplantation was significantly higher for tumors with a labeling index and vascular density above the median value compared to tumors with both parameters below the median (82% vs. 35%). Fifty percent of the tumors retained their proliferation patterns after xenotransplantation. Conclusion: The categorization by proliferation pattern previously described by others was reproduced quantitatively and spatially related to the vascular network using a computerized image processing system. The combination of quantitative and architectural information of multiple microenvironmental parameters adds a new dimension to the study of treatment resistance mechanisms. Tumor models representative of the various patterns can be used to further investigate the relevance of these architectural patterns

  10. Compiler issues associated with safety-related software

    International Nuclear Information System (INIS)

    Feinauer, L.R.

    1991-01-01

    A critical issue in the quality assurance of safety-related software is the ability of the software to produce identical results, independent of the host machine, operating system, or compiler version under which the software is installed. A study is performed using the VIPRE-0l, FREY-01, and RETRAN-02 safety-related codes. Results from an IBM 3083 computer are compared with results from a CYBER 860 computer. All three of the computer programs examined are written in FORTRAN; the VIPRE code uses the FORTRAN 66 compiler, whereas the FREY and RETRAN codes use the FORTRAN 77 compiler. Various compiler options are studied to determine their effect on the output between machines. Since the Control Data Corporation and IBM machines inherently represent numerical data differently, methods of producing equivalent accuracy of data representation were an important focus of the study. This paper identifies particular problems in the automatic double-precision option (AUTODBL) of the IBM FORTRAN 1.4.x series of compilers. The IBM FORTRAN version 2 compilers provide much more stable, reliable compilation for engineering software. Careful selection of compilers and compiler options can help guarantee identical results between different machines. To ensure reproducibility of results, the same compiler and compiler options should be used to install the program as were used in the development and testing of the program

  11. Addressing security issues related to virtual institute distributed activities

    Science.gov (United States)

    Stytz, Martin R.; Banks, Sheila B.

    2008-03-01

    One issue confounding the development and experimentation of distributed modeling and simulation environments is the inability of the project team to identify and collaborate with resources, both human and technical, from outside the United States. This limitation is especially significant within the human behavior representation area where areas such as cultural effects research and joint command team behavior modeling require the participation of various cultural and national representatives. To address this limitation, as well as other human behavior representation research issues, NATO Research and Technology Organization initiated a project to develop a NATO virtual institute that enables more effective and more collaborative research into human behavior representation. However, in building and operating a virtual institute one of the chief concerns must be the cyber security of the institute. Because the institute "exists" in cyberspace, all of its activities are susceptible to cyberattacks, subterfuge, denial of service and all of the vulnerabilities that networked computers must face. In our opinion, for the concept of virtual institutes to be successful and useful, their operations and services must be protected from the threats in the cyber environment. A key to developing the required protection is the development and promulgation of standards for cyber security. In this paper, we discuss the types of cyber standards that are required, how new internet technologies can be exploited and can benefit the promulgation, development, maintenance, and robustness of the standards. This paper is organized as follows. Section One introduces the concept of the virtual institutes, the expected benefits, and the motivation for our research and for research in this area. Section Two presents background material and a discussion of topics related to VIs, uman behavior and cultural modeling, and network-centric warfare. Section Three contains a discussion of the

  12. Proliferation Rates of Bovine Primary Muscle Cells Relate to Liveweight and Carcase Weight in Cattle

    Science.gov (United States)

    Coles, Chantal A.; Wadeson, Jenny; Leyton, Carolina P.; Siddell, Jason P.; Greenwood, Paul L.; White, Jason D.; McDonagh, Matthew B.

    2015-01-01

    Muscling in cattle is largely influenced by genetic background, ultimately affecting beef yield and is of major interest to the beef industry. This investigation aimed to determine whether primary skeletal muscle cells isolated from different breeds of cattle with a varying genetic potential for muscling differ in their myogenic proliferative capacity. Primary skeletal muscle cells were isolated and cultured from the Longissimus muscle (LM) of 6 month old Angus, Hereford and Wagyu X Angus cattle. Cells were assessed for rate of proliferation and gene expression of PAX7, MYOD, MYF5, and MYOG. Proliferation rates were found to differ between breeds of cattle whereby myoblasts from Angus cattle were found to proliferate at a greater rate than those of Hereford and Wagyu X Angus during early stages of growth (5–20 hours in culture) in vitro (P cattle (P cattle (P cattle. PMID:25875203

  13. Paul Karl Feyerabend: The Projections of Theoretical Proliferation in the Relation Science-Metaphysics

    Directory of Open Access Journals (Sweden)

    María Teresa Gargiulo de Vázquez

    2015-05-01

    Full Text Available The Paul Karl Feyerabend’s doctrine of theoretical proliferation has been interpreted by his experts as an attempt to preserve the ideal of scientific progress. This hermeneutics describes, in part, the intention of our philosopher. However, this reading does not explain the fundamental criticism that theoretical pluralism supposes for Feyerabend. The theoretical proliferation is itself a reductio ad absurdum of the attempts of logical positivism and critical rationalism to define science at the expense of the metaphysical. This article presents the theoretical proliferation as a vindication of the positive role that the metaphysical plays in scientific practice. We expose the Feyerabend’s defense of metaphysics inasmuch as it is constitute the possibility to overcome the conceptual conservatism, to increase empirical content of science and to recover the descriptive value of scientific theories.

  14. Pain-related psychological issues in hand therapy.

    Science.gov (United States)

    Hamasaki, Tokiko; Pelletier, René; Bourbonnais, Daniel; Harris, Patrick; Choinière, Manon

    Literature review. Pain is a subjective experience that results from the modulation of nociception conveyed to the brain via the nervous system. Perception of pain takes place when potential or actual noxious stimuli are appraised as threats of injury. This appraisal is influenced by one's cognitions and emotions based on her/his pain-related experiences, which are processed in the forebrain and limbic areas of the brain. Unarguably, patients' psychological factors such as cognitions (eg, pain catastrophizing), emotions (eg, depression), and pain-related behaviors (eg, avoidance) can influence perceived pain intensity, disability, and treatment outcomes. Therefore, hand therapists should address the patient pain experience using a biopsychosocial approach. However, in hand therapy, a biomedical perspective predominates in pain management by focusing solely on tissue healing. This review aims to raise awareness among hand therapists of the impact of pain-related psychological factors. This literature review allowed to describe (1) how the neurophysiological mechanisms of pain can be influenced by various psychological factors, (2) several evidence-based interventions that can be integrated into hand therapy to address these psychological issues, and (3) some approaches of psychotherapy for patients with maladaptive pain experiences. Restoration of sensory and motor functions as well as alleviating pain is at the core of hand therapy. Numerous psychological factors including patients' beliefs, cognitions, and emotions alter their pain experience and may impact on their outcomes. Decoding the biopsychosocial components of the patients' pain is thus essential for hand therapists. Copyright © 2018 Hanley & Belfus. Published by Elsevier Inc. All rights reserved.

  15. Proliferation risks

    International Nuclear Information System (INIS)

    Carchon, R.

    1998-09-01

    The report gives an overview of different aspects related to safeguards of fissile materials. Existing treaties including the Non-Proliferation Treaty, and the Tlatelolco and the Rarotonga Treaties are discussed. An overview of safeguards systems for the control of fissile materials as well as the role of various authorities is given. An overall overview of proliferation risks, the physical protection of fissile materials and the trade in fissile materials is given. Finally, the status in problem countries and de facto nuclear weapon states is discussed

  16. Monitoring asthma in childhood: management-related issues

    Directory of Open Access Journals (Sweden)

    Bart L. Rottier

    2015-06-01

    Full Text Available Management-related issues are an important aspect of monitoring asthma in children in clinical practice. This review summarises the literature on practical aspects of monitoring including adherence to treatment, inhalation technique, ongoing exposure to allergens and irritants, comorbid conditions and side-effects of treatment, as agreed by the European Respiratory Society Task Force on Monitoring Asthma in Childhood. The evidence indicates that it is important to discuss adherence to treatment in a non-confrontational way at every clinic visit, and take into account a patient's illness and medication beliefs. All task force members teach inhalation techniques at least twice when introducing a new inhalation device and then at least annually. Exposure to second-hand tobacco smoke, combustion-derived air pollutants, house dust mites, fungal spores, pollens and pet dander deserve regular attention during follow-up according to most task force members. In addition, allergic rhinitis should be considered as a cause for poor asthma control. Task force members do not screen for gastro-oesophageal reflux and food allergy. Height and weight are generally measured at least annually to identify individuals who are susceptible to adrenal suppression and to calculate body mass index, even though causality between obesity and asthma has not been established. In cases of poor asthma control, before stepping up treatment the above aspects of monitoring deserve closer attention.

  17. Do medical students require education on issues related to plagiarism?

    Science.gov (United States)

    Varghese, Joe; Jacob, Molly

    2015-01-01

    In the course of our professional experience, we have seen that many medical students plagiarise. We hypothesised that they do so out of ignorance and that they require formal education on the subject. With this objective in mind, we conducted a teaching session on issues related to plagiarism. As a part of this, we administered a quiz to assess their baseline knowledge on plagiarism and a questionnaire to determine their attitudes towards it. We followed this up with an interactive teaching session, in which we discussed various aspects of plagiarism. We subjected the data obtained from the quiz and questionnaire to bivariate and multivariate analysis. A total of 423 medical students participated in the study. Their average score for the quiz was 4.96±1.67 (out of 10). Age, gender and years in medical school were not significantly associated with knowledge regarding plagiarism. The knowledge scores were negatively correlated with permissive attitudes towards plagiarism and positively correlated with attitudes critical of the practice. Men had significantly higher scores on permissive attitudes compared to women . In conclusion, we found that the medical students' knowledge regarding plagiarism was limited. Those with low knowledge scores tended to have permissive attitudes towards plagiarism and were less critical of the practice. We recommend the inclusion of formal instruction on this subject in the medical curriculum, so that this form of academic misconduct can be tackled.

  18. Long term energy-related environmental issues of copper production

    Energy Technology Data Exchange (ETDEWEB)

    Alvarado, S. [University of Chile, Santiago (Chile). Dept. of Mechanical Engineering; Maldonado, P.; Barrios, A.; Jaques, I. [University of Chile, Santiago (Chile). Energy Research Program

    2002-02-01

    Primary copper production is a major activity in the mining sector of several countries. However, it is highly energy-intensive and poses important environmental hazards. In the case of Chile, the world's largest copper producer (40% of world total), we examine its energy consumption and energy-related environmental implications over a time horizon of 25 years. Concerning the latter, we focus on greenhouse-gas (GHG) emissions, one of the most debated environmental issues. This paper follows up our previous report in which the current situation was analyzed and a particular technical option for improving the energy efficiency and concurrently reducing GHG emissions was discussed. Estimated reference or base (BS) and mitigation (MS) scenarios are developed for the period ending in 2020. The former assesses the energy demand projected in accordance with production forecasts and specific energy consumption patterns (assuming that energy efficiency measures are adopted 'spontaneously') with their resultant GHG emissions, while the latter assumes induced actions intended to reduce emissions by adopting an aggressive policy of efficient energy use. For the year 2020, the main results are: (i) BS, 1214 t of CO{sub 2}/ton of refined copper content (49% lower than in 1994); (ii) MS, 1037 t of CO{sub 2}/t of refined copper content (56% lower than in 1994). CO{sub 2} emissions have been estimated considering both fuel and electricity process requirements. (author)

  19. Long term energy-related environmental issues of copper production

    International Nuclear Information System (INIS)

    Alvarado, S.; Maldonado, P.; Barrios, A.; Jaques, I.

    2002-01-01

    Primary copper production is a major activity in the mining sector of several countries. However, it is highly energy-intensive and poses important environmental hazards. In the case of Chile, the world's largest copper producer (40% of world total), we examine its energy consumption and energy-related environmental implications over a time horizon of 25 years. Concerning the latter, we focus on greenhouse-gas (GHG) emissions, one of the most debated environmental issues. This paper follows up our previous report in which the current situation was analyzed and a particular technical option for improving the energy efficiency and concurrently reducing GHG emissions was discussed. Estimated reference or base (BS) and mitigation (MS) scenarios are developed for the period ending in 2020. The former assesses the energy demand projected in accordance with production forecasts and specific energy consumption patterns (assuming that energy efficiency measures are adopted 'spontaneously') with their resultant GHG emissions, while the latter assumes induced actions intended to reduce emissions by adopting an aggressive policy of efficient energy use. For the year 2020, the main results are: (i) BS, 1214 t of CO 2 /ton of refined copper content (49% lower than in 1994); (ii) MS, 1037 t of CO 2 /t of refined copper content (56% lower than in 1994). CO 2 emissions have been estimated considering both fuel and electricity process requirements. (author)

  20. Atmospheric Weathering of Historic Monuments and Their Related Conservation Issues

    Directory of Open Access Journals (Sweden)

    Caner-Saltık Emine N.

    2018-01-01

    Full Text Available Atmospheric environment affects the materials of historic monuments and their structure starting from the time of their construction. Daily and seasonal changes in temperature and humidity, wind, snow and rainfall, soluble salts carried by water, biological agents, pollutant gases and particulate matter are some of the agents in atmospheric environment that introduce weathering by physical, chemical and biological processes in the materials of the monuments such as natural building stones, bricks, mortars and plasters, mud brick etc. The weathering processes need to be well diagnosed by identification of main mechanisms of decay and major responsible agents, degree and depth of deterioration expressed with measurable parameters of physical, physicomechanical properties, and micro structural changes together with their distribution on the monument. Success of conservation treatments strongly depend on those diagnostic studies and compatibility of the treatments with the deteriorated and relatively sound parts of the historic materials. Current approach to materials conservation is to be able to make minimum intervention to historic material by targeting the conservation treatment to the deteriorated area for the purpose of controlling the deterioration factors and achieving compatible and durable conservation of historical material. In this presentation, two examples of diagnostic research and conservation treatments based on and guided by the diagnostic results are summarized concerning historic stone monuments exposed to atmospheric environment since more than two thousand years. The first example is on the marble walls of Temple of Augustus in Ankara exposed to polluted urban atmosphere. The second example is on the limestone statues of Nemrut Mount Monument in Adıyaman-Turkey, exposed to rural atmosphere with harsh climatic conditions. Finally, a brief discussion on current research issues related to historic materials conservation in

  1. The Concept of Cultural Relativity in Moral Judgments Concerning Gender-Related Issues.

    Science.gov (United States)

    Boyd, D. R.; And Others

    The comparative study was designed to determine whether cultural relativism and ethical reasoning develop in a hierarchical manner when applied to culturally different phenomena. The phenomena investigated were moral judgments concerning gender-related issues. Thirty-six first through sixth-grade students from two private schools and 130…

  2. 41 CFR 109-43.307-52 - Nuclear-related or proliferation-sensitive personal property.

    Science.gov (United States)

    2010-07-01

    ... as practicable, any civilian utility or commercial value of the personal property. ... proliferation-sensitive personal property. 109-43.307-52 Section 109-43.307-52 Public Contracts and Property... MANAGEMENT REGULATIONS UTILIZATION AND DISPOSAL 43-UTILIZATION OF PERSONAL PROPERTY 43.3-Utilization of...

  3. Issues in radiology related to the new technologies

    International Nuclear Information System (INIS)

    Elkin, M.

    1982-01-01

    A number of interrelated issues facing radiology have been highlighted by our new technologies. The issues discussed in this presentation are: subspecialization of radiology; the use of economic analyses (CEA/CBA) to judge the cost effectiveness of radiologic procedures, the alleged overuse of radiologic examinations; and the need for the diagnostic radiologist to become more actively involved in patient management

  4. Methodological Issues in HIV-Related Social Research in Nigeria

    African Journals Online (AJOL)

    AJRH Managing Editor

    Methodological Issues in HIV/AIDS Social Research in Nigeria ... convaincue au commencement de l'étude qu'une étude sur l'interaction entre le VIH/sida et les questions sensibles comme les ..... One of the vexed issues was the requirement.

  5. Issues Raised in Relation to Radioactive Waste Management

    International Nuclear Information System (INIS)

    Atherton, Elizabeth

    2003-01-01

    Nirex has undertaken various consultations with different stakeholders to identify their issues and concerns about radioactive waste management in general and specific aspects of Nirex's work. This paper will outline what dialogue techniques Nirex has undertaken and the issues and concerns that people have raised during the events. It will outline some of the work that Nirex is undertaking to address stakeholders' issues and concerns. Nirex has used a variety of dialogue techniques co-ordinated under the Nirex Involvement Programme to engage with stakeholders about the work we undertake. We are now trying to address the issues, concerns, scenarios and questions raised in our work programme. Key lessons that we have learned in undertaking the dialogues include: The importance of appropriate facilitation and organisation of meetings; The need for a clear purpose for meetings; Being flexible to the needs of the attendees and the issues they raise; Providing feedback to those who participate and following up issues. Through engaging with the public Nirex has learned that: Radioactive waste is not an everyday concern for people; The public can, will and want to engage with the issue of radioactive waste management. This includes engaging with the ethical debate. To facilitate this Nirex and others need to: Provide information in a neutral form outlining the pros and cons and including various people's opinions; Use proactive techniques to allow access and space for people to discuss the issues; Demonstrate how people's opinions have been taken into account. People understand the issues very differently to the way institutions understand them. There is a need for institutions to learn to understand public concerns and the ways in which the public understand issues, as well as for the public to understand the institutional positions better. We are using these insights to develop our future work in this area

  6. LABOUR MARKET INTEGRATION ISSUES RELATED TO MIGRANTS ARRIVING TO HUNGARY

    Directory of Open Access Journals (Sweden)

    Peter Miklos Komives

    2016-07-01

    Full Text Available The migration flows appearing in the recent years have gained central relevance in Hungary. Previously people were having no opinion about the current situation of issues related to migration but the increased media attention lead to the development of mixed attitudes among people. Some people feel sorry for the families who are coming from the war zones and lost their homes, others have fear of losing their position at work, or their families because of the acts they have heard from the media and they are hostile to the issue of integration whether it is about education or the labour market. According to the statistical data; in the third quarter of 2015, more than hundred thousand asylum-seekers arrived to Hungary, which dropped drastically in the fourth quarter caused by the significant transformation of the asylum process. This study is intended to serve two objectives: first describe the comprehensive picture of labour market attitudes towards migrants and secondly to identify factors that affect the employment of foreigners in Hungary using secondary data sources. Based on this analysis those questions can be formulated, which may constitute a basis for further labour market researches for the integration of migrants. From our point of view there are vital aspects of the migrants’ successful social integration; we have to integrate the migrants who are coming to our country and plan to stay for a longer time to the field of education and the labour market. The social integration of migrants in a country is closely linked to employment, to the integration into the labour market, and in many cases one of the obstacles in this regard is the prejudiced behaviour and negative attitudes towards migrants which manifests itself as the discrimination in the labour market. The results of the European Commission confirm that in Hungary the ethnicity as a variable appears to be the second on the list of the most serious discrimination factors

  7. Sedentary lifestyle related exosomal release of Hotair from gluteal-femoral fat promotes intestinal cell proliferation

    OpenAIRE

    Xiaozhao Lu; Danna Bai; Xiangwei Liu; Chen Zhou; Guodong Yang

    2017-01-01

    Pioneering epidemiological work has established strong association of sedentary lifestyle and obesity with the risk of colorectal cancer, while the detailed underlying mechanism remains unknown. Here we show that Hotair (HOX transcript antisense RNA) is a pro-adipogenic long non-coding RNA highly expressed in gluteal-femoral fat over other fat depots. Hotair knockout in adipose tissue results in gluteal-femoral fat defect. Squeeze of the gluteal-femoral fat induces intestinal proliferation in...

  8. Sedentary lifestyle related exosomal release of Hotair from gluteal-femoral fat promotes intestinal cell proliferation.

    Science.gov (United States)

    Lu, Xiaozhao; Bai, Danna; Liu, Xiangwei; Zhou, Chen; Yang, Guodong

    2017-03-31

    Pioneering epidemiological work has established strong association of sedentary lifestyle and obesity with the risk of colorectal cancer, while the detailed underlying mechanism remains unknown. Here we show that Hotair (HOX transcript antisense RNA) is a pro-adipogenic long non-coding RNA highly expressed in gluteal-femoral fat over other fat depots. Hotair knockout in adipose tissue results in gluteal-femoral fat defect. Squeeze of the gluteal-femoral fat induces intestinal proliferation in wildtype mice, while not in Hotair knockout mice. Mechanistically, squeeze of the gluteal-femoral fat induces exosomal Hotair secretion mainly by transcriptional upregulation of Hotair via NFκB. And increased exosomal Hotair in turn circulates in the blood and is partially endocytosed by the intestine, finally promoting the stemness and proliferation of intestinal stem/progenitor cells via Wnt activation. Clinically, obese subjects with sedentary lifestyle have much higher exosomal HOTAIR expression in the serum. These findings establish that sedentary lifestyle promotes exosomal Hotair release from the gluteal-femoral fat, which in turn facilitates intestinal stem and/or progenitor proliferation, raising a possible link between sedentary lifestyle with colorectal tumorigenesis.

  9. Engineering approach to relative quantitative assessment of safety culture and related social issues in NPP operation

    International Nuclear Information System (INIS)

    Sivokon, V.; Gladyshev, M.; Malkin, S.

    2005-01-01

    The report is devoted to presentation of engineering approach and software tool developed for Safety Culture (SC) assessment as well as to the results of their implementation at Smolensk NPP. The engineering approach is logic evolution of the IAEA ASSET method broadly used at European NPPs in 90-s. It was implemented at Russian and other plants including Olkiluoto NPP in Finland. The approach allows relative quantitative assessing and trending the aspects of SC by the analysis of evens features and causes, calculation and trending corresponding indicators. At the same time plant's operational performances and related social issues, including efficiency of plant operation and personnel reliability, can be monitored. With the help of developed tool the joint team combined from personnel of Smolensk NPP and RRC 'Kurchatov Institute' ('KI') issued the SC self-assessment report, which identifies: families of recurrent events, main safety and operational problems ; their trends and importance to SC and plant efficiency; recommendations to enhance SC and operational performance

  10. Issues related to choosing a guard force structure

    International Nuclear Information System (INIS)

    Averbach, C.; Cusack, J.; Green, L.; Higinbotham, W.; Indusi, J.; Marcuse, W.; Weinstock, E.

    1975-01-01

    The establishment of a federal security force has been suggested as an additional step to protect nuclear material. The force would be given the responsibility for guarding nuclear facilities and shipments of nuclear materials. A study to identify the issues that are relevant to choosing between the private guard forces that are presently employed by industry or a guard force under federal authority is summarized. To examine the issues which would be relevant, three possible types of security force structures were selected for comparison: a federal force under central authority, a private guard force employed by or under contract to a facility, and a private arrangement to employ local police officers similar to the arrangement for armed guards at airports. The issues were divided into seven categories: (1) legal considerations, (2) liability, (3) staffing and operations, (4) costs, (5) relationship to off-site forces, (6) management and control, and (7) transportation. (U.S.)

  11. Issues related to choosing a guard force structure

    International Nuclear Information System (INIS)

    Auerback, C.; Cusack, J.; Green, L.; Higinbotham, W.; Indusi, J.; Marcuse, W.; Weinstock, E.

    1975-01-01

    The establishment of a federal security force has been suggested as an additional step to protect nuclear material. The force would be given the responsibility for guarding nuclear facilities and shipments of nuclear materials. This paper summarizes a study to identify the issues that are relevant to choosing between the private guard forces that are presently employed by industry or a guard force under federal authority. To examine the issues which would be relevant, three possible types of security force structures were selected for comparison: a federal force under central authority, a private guard force employed by or under contract to a facility, and a private arrangement to employ local police officers similar to the arrangement for armed guards at airports. The issues were divided into seven categories: (1) Legal Considerations, (2) Liability, (3) Staffing and Operations, (4) Costs, (5) Relationship to Off-site Forces, (6) Management and Control, (7) Transportation

  12. Jordan: U.S. Relations and Bilateral Issues

    Science.gov (United States)

    2007-01-25

    bring about a compromise solution to Iraq’s sectarian violence and insurgency. Nevertheless, should the Administration heed the main recommendations of...Committee (NLC), a New York-based human rights advocacy group, issued a 161-page report alleging sweatshop -like conditions in 28 out of 100 Qualified

  13. Relating Social Inclusion and Environmental Issues in Botanic Gardens

    Science.gov (United States)

    Vergou, Asimina; Willison, Julia

    2016-01-01

    Botanic gardens have been evolving, responding to the changing needs of society, from their outset as medicinal gardens of monasteries and university gardens to more recently as organizations that contribute to the conservation of plant genetic resources. Considering that social and environmental issues are deeply intertwined and cannot be tackled…

  14. Neglected Issues Relating to African Health Systems: An Incentive ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Several issues that affect access to and quality of health care for the poor and ... Conferences will be held at local, district and national levels to share the results of the ... Minister Bibeau announces appointments of IDRC's President and new ...

  15. Teacher-Student Sexual Relations: Key Risks and Ethical Issues

    Science.gov (United States)

    Sikes, Pat

    2010-01-01

    Researching actual or purported sexual contact between teachers and students raises many difficult ethical issues, questions and dilemmas, which may help to explain why few have ventured into the field. This experientially based paper addresses key problem areas under the headings of: the ethics of researching a sensitive taboo topic; the ethics…

  16. Ecological Issues Related to Children's Health and Safety

    Science.gov (United States)

    Aldridge, Jerry; Kohler, Maxie

    2009-01-01

    Issues concerning the health and safety of children and youth occur at multiple levels. Bronfenbrenner (1995) proposed an ecological systems approach in which multiple systems interact to enhance or diminish children's development. The same systems are at work in health promotion. The authors present and review articles that reflect the multiple…

  17. Thinking, Relating and Choosing: Resolving the issue of Faith ...

    African Journals Online (AJOL)

    Which is worse: Doing evil or being evil? If we are free to define ourselves through our choices, as existentialism posits, then the latter is worse. This paper attempts to resolve the issue of the difference between religious (group) ethics and the ethics of a person of faith that embraces individuals with an existential ...

  18. Current issues in libraries, information science and related fields

    CERN Document Server

    Woodsworth, Anne

    2015-01-01

    This volume is unusual in that the theme is quite broad in scope yet focused on a specific topic; innovations and boundary-pushing studies in areas not usually found in library literature. It examines the periphery of the field surveyed in previous volumes. The chapters are grouped in two categories: professional issues and transforming services.

  19. Review of spent fuel related issues in SKB's SR 97

    International Nuclear Information System (INIS)

    Grambow, B.

    2000-01-01

    The solid waste form 'spent fuel' constitutes both the dominant radionuclide source as well as a first radionuclide retention barrier of a planned future high level nuclear waste isolation systems in deep granite formations. In order to evaluate the performance of spent fuel as part of the multibarrier containment system in a deep repository, the radionuclide release properties in groundwater must be predicted over very long time periods. Radionuclide release is not an inherent materials property of the fuel but depends, besides fuel specific parameters, mainly on time but as well on the geochemical and hydraulic environment of the disposal location. The study SR 97 documents the large effort of SKB to assess the long-term performance of a repository containing spent nuclear fuel. Scenario and consequence analyses are clearly described, considering major physical and chemical interactions of the various components of the multi-barrier isolation system. The approach attempts to assess both a realistic and a pessimistic evolution scenario. The present report attempts to evaluate whether this approach is thoroughly carried through to assess the performance of spent nuclear fuel in a repository. Main issues are radionuclide inventories and inventory distribution between structural parts of the fuel assembly and the fuel matrix, potential fuel alteration prior to water access, as well as models for fuel matrix dissolution and instant release fractions. Uncertainties in radionuclide inventories are discussed and were found for many radionuclides to be higher than assumed in SR 97. This is particularly true for Cl-36. This nuclide is a potential key biosphere dose contributor in various international safety assessments. Of particular importance are uncertainties related to the partition of radionuclides between metallic parts of the fuel assembly and the fuel matrix, since inventories of metallic parts are considered to be released instantaneously. Using C-14 as an

  20. Suppression of lymphocyte proliferation by marijuana components is related to cell number and cell source

    International Nuclear Information System (INIS)

    Klein, T.; Pross, S.; Newton, C.; Friedman, H.

    1986-01-01

    Conflicting reports have appeared concerning the effect of marijuana components on immune responsiveness. The authors have observed that the effect of cannabinoids on lymphocyte proliferation varied with both the concentration of the drug and the mitogen used. They now report that at a constant concentration of drug, the cannabinoid effect varied from no effect to suppression depending upon the number of cells in culture and the organ source of the cells. Dispersed cell suspensions of mouse lymph node, spleen, and thymus were prepared and cultured at varying cell numbers with either delta-9-tetrahydrocannabinol or 11-hydroxy-delta-9-tetrahydrocannabinol and various mitogens. Lymphocyte proliferation was analyzed by 3 H-thymidine incorporation. T-lymphocyte mitogen responses in cultures containing high cell numbers were unaffected by the cannabinoids but as cell numbers were reduced a suppression of the response was observed. Furthermore, thymus cells were considerably more susceptible to cannabinoid suppression than cells from either lymph node or spleen. These results suggest that certain lymphocyte subpopulations are more sensitive to cannabinoid suppression and that in addition to drug concentration other variables such as cell number and cell source must be considered when analyzing cannabinoid effects

  1. Structural Integrity and Aging-Related Issues of Helicopters

    Science.gov (United States)

    2000-10-01

    inherently damage lolerant , any damage- inspection in critical locations where tests have indicated tolerant features in airframe design only enhances...required, so European Rotorcraft Forum. Marseilles, France, 15- that helicopters are equipped with such features as fly- 17 September 1998 . by-wire and...fatigue Evaluation of structural integrity issues of aging helicopters. The Structure," 29 April, 1998 . extended safe-life approach encompasses the best

  2. Issues related to the use of genetic material and information.

    Science.gov (United States)

    Giarelli, E; Jacobs, L A

    2000-04-01

    To review issues regarding the use of genetic materials and information. Professional literature, regional and federal legislation. An analysis is provided of the relationship among advances in genetic technology, use of genetic material and information, and the development of laws that protect the interests of donors, researchers, and insurers. Rapid technological achievements have generated complex questions that are difficult to answer. The Human Genome Project began and the scientific discoveries were put to use before adequate professional and public debate on the ethical, legal, social, and clinical issues. The term "proper use" of genetic material and information is not defined consistently. An incomplete patchwork of protective state and federal legislation exists. Many complicated issues surround the use and potential misuse of genetic material and information. Rapidly advancing technology in genetics makes it difficult for regulations that protect individuals and families to keep pace. Oncology nurses need to recognize their role as change agents, understand genetic technology, and advocate for patients by participating in the debate on the proper use and prevention of misuse of genetic material and information.

  3. LEGAL ISSUES RELATED TO THE SHARIAH ADVISORY COUNCIL IN MALAYSIA

    Directory of Open Access Journals (Sweden)

    Norhashimah Mohd Yasin

    2013-08-01

    Full Text Available Malaysia has always aspired to be the hub for Islamic banking and finance. Various measures have been, and are being, carried out to promote Malaysia as an international Islamic banking and financial centre. As the backbone for this, the national Shariah Advisory Council (SAC has been established under the auspices of the Central Bank of Malaysia Act 1958 (CBMA. Under the CBMA, the SAC has been conferred a statutory function as the authority for the ascertainment of Islamic law for the purposes of Islamic banking, as well as business and other types of Islamic financial businesses. In 2009, the CBMA 1958 was replaced and repealed. With the coming into force of the CBMA 2009, the role and functions of the SAC was reinforced and upgraded in terms of appointments of members and, most importantly, that the Shariah rulings pursuant to any reference made to the SAC by the Civil court or arbitrator concerning Shariah matters shall be binding on the Islamic financial institutions as well as on the court and any arbitrator. The issue of whether or not the SAC is the final arbiter on Islamic banking and finance disputes or, in other words, there is no longer a process of judicial review where it involves Shariah matters, will be the highlight of this paper. To what extent does the post CBMA 2009 solve the binding nature of the SAC upon the Civil courts of Malaysia as its rulings and directives are only relevant to ‘Shariah’ issues? What would be the situations if the issues of the Islamic banking and finance cases are deemed not to amount to a ‘Shariah’ issue, but are purely on banking, land matters or contractual interpretations? Has there any actual legal reform been brought about by this amendment or is it merely a cosmetic changes? If the court were to be bound by the SAC rulings, does this not usurp the independence of the judiciary which is the corner stone of the principle of separation of powers between the executive, the legislature and

  4. Dealing with quantum weirdness: Holism and related issues

    International Nuclear Information System (INIS)

    Elby, A.R.

    1995-12-01

    Various issues are discussed in interpretation of quantum mechanics. All these explorations point toward the same conclusion, that some systems are holistically connected, i.e., some composite systems have properties that cannot, even in principle, be reduced to the properties of its subsystems. This is argued to be the central metaphysical lesson of quantum theory; this will remain pertinent even if quantum mechanics gets replaced by a superior theory. Chap. 2 discusses nonlocality and rules out hidden-variable theories that approximately reproduce the perfect correlations of quantum mechanics, as well as theories that obey locality conditions weaker than those needed to derive Bell's inequality. Chap. 3 shows that SQUID experiments can rule out non-invasive measurability if not macrorealism. Chap. 4 looks at interpretational issues surrounding decoherence, the dissipative interaction between a system and its environment. Decoherence klcan help ''modal'' interpretations pick out the desired ''preferred'' basis. Chap. 5 explores what varieties of causation can and cannot ''explain'' EPR correlations. Instead of relying on ''watered down'' causal explanations, we should instead develop new, holistic explanatory frameworks

  5. The approach of nuclear related issues by the press

    International Nuclear Information System (INIS)

    Manetti, Cristiane Teixeira; Tanimoto, Katia Suemi; Hiromoto, Goro

    2009-01-01

    Nuclear energy has always been a polemic issue, and it is usually more intensely associated, by the general public, to the risks than to the benefits from its use; in this sense, the mass media have clearly had its share of responsibility for public opinion formation. This paper presents a report on the coverage of the nuclear issue in the press, identifying the amount of negative and positive views on the subject, as well as the people involved in the process. The analysis comprises the period from February 2007 to February 2008, right after the edition of the 4th IPCC Report. From that sample, 172 texts published in widely known newspapers and magazines, most of them from Sao Paulo State, were identified. The analyzed speeches were classified according to five information sources: specialists, users, authorities, protagonists and entrepreneurs. It was noted the predominance of positive articles, mainly due to the weight of the favorable speeches by authorities, cited as the most frequent in this paper. (author)

  6. Environmental issues related to oil and gas access

    International Nuclear Information System (INIS)

    Antoniuk, T.

    1998-01-01

    This presentation discussed the environmental issues that petroleum companies face in northeast British Columbia. Petroleum exploration, development, production, abandonment and transportation activities in the province must follow provincial and federal regulations as well as government policies and guidelines which define environmental assessment, protection, and mitigation standards. A discussion about the regulatory framework in British Columbia can be found in the 'British Columbia Oil and Gas Handbook' which is available on the INTERNET at http://natural.gov.bc.ca/handpubs/oilgashb/bcoghb.htm. It was suggested that companies wishing to conduct drilling or exploration activities in sensitive areas should allow extra time (up to one year) to obtain approval for such activities. British Columbia's environmental setting includes five zones - the Alpine Tundra, the Spruce-Willow-Birch zone, the Engelmannn Spruce-Subalpine Fir forests, the Sub-Boreal Spruce zone, and the Boreal White and Black Spruce zone. Four discrete oil and gas guideline zones with differing standards have been developed. These are: (1) the Northern Rocky Mountains, (2) the Northeastern Slopes, (3) the Southeastern Slopes, and (4) the Northern Plains. A set of interim environmental guidelines are in effect to direct activity away from any sensitive area. Three sub-regional land use planning areas have also been established in the Prince George Forest Region which includes Dawson Creek, Fort St. John and Fort Nelson. Petroleum operators in these regions are obliged to deal with issues regarding aboriginal involvement, stream crossings, access management, and air quality. 40 refs

  7. Contemporary Expert Debates on the SCO-Related Issues

    Directory of Open Access Journals (Sweden)

    Igor Evgen'evich Denisov

    2016-01-01

    Full Text Available Since its establishment the SCO has always attracted a lot of expert attention. The SCO Forum was founded in 2006 to bring together for annual debates experts from all member-states. Within this format in-depth discussions took place in April 2016 in Dushanbe, which hosted this year conference of the SCO Forum. Participating experts and officials reviewed problems of security, economic cooperation (including transport and water-energy issues and SCO enlargement, the latter being one of the most debatable. Experts presented some new thesis on all these problems, in particular on the enlargement issue. These new thesis are summed up in this article. Besides, the SCO Forum this year had many statements on the organization approaching a sort of new phase in its development. This line of discussions may lead in the future to even more active debates on SCO's role in the world. This article puts emphasis on the new elements of these debates and reviews major experts' attitudes within this line of discussion on the SCO being in front of a new stage of development.

  8. The approach of nuclear related issues by the press

    Energy Technology Data Exchange (ETDEWEB)

    Manetti, Cristiane Teixeira; Tanimoto, Katia Suemi; Hiromoto, Goro [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)], e-mail: cristianemanetti@hotmail.com, e-mail: katia_tanimoto@hotmail.com, e-mail: hiromoto@ipen.br

    2009-07-01

    Nuclear energy has always been a polemic issue, and it is usually more intensely associated, by the general public, to the risks than to the benefits from its use; in this sense, the mass media have clearly had its share of responsibility for public opinion formation. This paper presents a report on the coverage of the nuclear issue in the press, identifying the amount of negative and positive views on the subject, as well as the people involved in the process. The analysis comprises the period from February 2007 to February 2008, right after the edition of the 4th IPCC Report. From that sample, 172 texts published in widely known newspapers and magazines, most of them from Sao Paulo State, were identified. The analyzed speeches were classified according to five information sources: specialists, users, authorities, protagonists and entrepreneurs. It was noted the predominance of positive articles, mainly due to the weight of the favorable speeches by authorities, cited as the most frequent in this paper. (author)

  9. Inter-organizational future proof EHR systems A review of the security and privacy related issues

    NARCIS (Netherlands)

    van der Linden, Helma; Kalra, Dipak; Hasman, Arie; Talmon, Jan

    2009-01-01

    OBJECTIVES: Identification and analysis of privacy and security related issues that occur when health information is exchanged between health care organizations. METHODS: Based on a generic scenario questions were formulated to reveal the occurring issues. Possible answers were verified in

  10. Quality of life issues relating to endocrine treatment options

    DEFF Research Database (Denmark)

    Iversen, P

    1999-01-01

    for measuring health-related quality of life should assess both overall and disease-specific quality of life. Data from two large studies of bicalutamide monotherapy show that this non-steroidal antiandrogen is associated with significant health-related quality of life advantages in the treatment of patients...

  11. Methodological issues related to studies of lead mobilization during menopause

    Directory of Open Access Journals (Sweden)

    Berkowitz Gertrud S.

    1999-01-01

    Full Text Available While there has been a substantial decline in lead exposure in the United States during the past two decades, mobilization of existing lead stored in bone potentially represents an important endogenous source of exposure for menopausal women. It has been hypothesized that lead may be mobilized from skeletal stores during conditions of high bone turnover, such as during menopause. However, such mobilization has not been documented in prospective studies. This discussion is focussed on some of the methodological difficulties to be anticipated in longitudinal studies of lead mobilization specific to menopause and the issues that need to be taken into account when evaluating the results of such studies. To evaluate whether lead mobilization occurs during menopause, a prospective repeated measures design is needed using X-ray fluorescence analysis of lead in bone and serial measurements of blood lead. Potential confounders and effect modifiers also need to be taken into account in the statistical analysis.

  12. PRECISION MEASUREMENT OF MUON G-2 AND ACCELERATOR RELATED ISSUES

    International Nuclear Information System (INIS)

    BROWN, H.N.; BUNCE, G.; CAREY, R.M.; CUSHMAN, P.; DANBY, G.T.; DEBEVEC, P.T.; DEILE, M.; DENG, H.; DENINGER, W.; DHAWAN, S.K.; MENG, W.

    2001-01-01

    A precision measurement of the anomalous g value, a μ =(g-2)/2, for the positive muon has been made using high intensity protons available at the Brookhaven AGS. The result based on the 1999 data a μ =11659202(14)(6) x 10 10 (1.3ppm) is in good agreement with previous measurements and has an error one third that of the combined previous data. The current theoretical value from the standard model is a μ (SM)=11659159.6(6.7) x 10 10 (0.57 ppm) and differ by over 2.5 standard deviation with experiment. Issues with reducing systematic errors and enhancing the injection and storage efficiencies are discussed

  13. Survey on Issues related to National Nuclear Promotion Policy

    International Nuclear Information System (INIS)

    Woo, Byungchool; Lee, Youngjoon; Lee, Youngcheol; Jeong, I. K.; Kim, Hyunjun; Kim, Youngsoo; Yun, Sungwon; Moon, Keehwan; Chung, Whansam

    2013-06-01

    Ο Major issues surrounding nuclear are including suspicions about nuclear safety, spent-fuel management, acquiring the advanced R and D capabilities and making the nuclear a creative industry Ο Solid measures for securing safety should be formulated and implemented for reducing public anxiety of nuclear use Ο The long-term R and D performance system from a scientific perspective should be established for expanding Research and Development for safer use of nuclear Ο The spent-fuel management policy should be determined through publicizing process Ο Establishing small and medium enterprises-oriented supply system of reactors and SMRs and Encouraging the radiation fusion technology industrialization for promoting creative industry utilizing nuclear

  14. Ethical issues related to caring for low birth weight infants.

    Science.gov (United States)

    Webb, Mary S; Passmore, Denise; Cline, Genieveve; Maguire, Denise

    2014-09-01

    Currently preterm births are the leading causes of newborn deaths and newborn mortality in developed countries. Infants born prematurely remain vulnerable to many acute complications and long-term disabilities. There is a growing concern surrounding the moral and ethical implications of the complex and technological care being provided to extremely low birth weight infants in neonatal intensive care units in the developed nations. The purpose of this study was to describe the ethical and moral issues that neonatal intensive care nurses experience when caring for low birth weight preterm infants and their families. A phenomenological method design was used to describe the lived experiences of nurses with ethical and moral issues encountered in the neonatal intensive care unit. One-on-one, semi-structured interviews using open-ended questions were used to gather data from the participants. The setting for this study was a 97-bed neonatal intensive care. A total of 16 female nurses were interviewed. Approval to conduct the research study was obtained from the institutional review board of the hospital where the study was conducted. Formal signed consent was obtained from each participant. To ensure confidentiality, each participant was asked to choose a confederate name to be used in the interview and the transcriptions. The thematic analysis identified five recurring themes: (a) at the edge of viability, (b) infant pain and discomfort, (c) crucial decisions, (d) communicating with parents, and (e) letting go. Neonatal intensive care unit nurses indicated that they often had challenges to their own sense of morality as they struggled to protect the infant from pain and unnecessary discomfort, provide care to an infant and their family whom they thought was faced with a lifetime of challenges and poor health, accepting decisions made by parents, and feeling as if parents were not adequately informed about outcomes. © The Author(s) 2014.

  15. Mechanical strain modulates age-related changes in the proliferation and differentiation of mouse adipose-derived stromal cells

    Directory of Open Access Journals (Sweden)

    Chiang Wen-Sheng

    2010-03-01

    Full Text Available Abstract Background Previous studies on the effects of aging in human and mouse mesenchymal stem cells suggest that a decline in the number and differentiation potential of stem cells may contribute to aging and aging-related diseases. In this report, we used stromal cells isolated from adipose tissue (ADSCs of young (8-10 weeks, adult (5 months, and old (21 months mice to test the hypothesis that mechanical loading modifies aging-related changes in the self-renewal and osteogenic and adipogenic differentiation potential of these cells. Results We show that aging significantly reduced the proliferation and increased the adipogenesis of ADSCs, while the osteogenic potential is not significantly reduced by aging. Mechanical loading (10% cyclic stretching, 0.5 Hz, 48 h increased the subsequent proliferation of ADSCs from mice of all ages. Although the number of osteogenic colonies with calcium deposition was increased in ADSCs subjected to pre-strain, it resulted from an increase in colony number rather than from an increase in osteogenic potential after strain. Pre-strain significantly reduced the number of oil droplets and the expression of adipogenic marker genes in adult and old ADSCs. Simultaneously subjecting ADSCs to mechanical loading and adipogenic induction resulted in a stronger inhibition of adipogenesis than that caused by pre-strain. The reduction of adipogenesis by mechanical strain was loading-magnitude dependent: loading with 2% strain only resulted in a partial inhibition, and loading with 0.5% strain could not inhibit adipogenesis in ADSCs. Conclusions We demonstrate that mechanical stretching counteracts the loss of self-renewal in aging ADSCs by enhancing their proliferation and, at the same time, reduces the heightened adipogenesis of old cells. These findings are important for the further study of stem cell control and treatment for a variety of aging related diseases.

  16. Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference.

    Science.gov (United States)

    Ezzedine, K; Lim, H W; Suzuki, T; Katayama, I; Hamzavi, I; Lan, C C E; Goh, B K; Anbar, T; Silva de Castro, C; Lee, A Y; Parsad, D; van Geel, N; Le Poole, I C; Oiso, N; Benzekri, L; Spritz, R; Gauthier, Y; Hann, S K; Picardo, M; Taieb, A

    2012-05-01

    During the 2011 International Pigment Cell Conference (IPCC), the Vitiligo European Taskforce (VETF) convened a consensus conference on issues of global importance for vitiligo clinical research. As suggested by an international panel of experts, the conference focused on four topics: classification and nomenclature; definition of stable disease; definition of Koebner's phenomenon (KP); and 'autoimmune vitiligo'. These topics were discussed in seven working groups representing different geographical regions. A consensus emerged that segmental vitiligo be classified separately from all other forms of vitiligo and that the term 'vitiligo' be used as an umbrella term for all non-segmental forms of vitiligo, including 'mixed vitiligo' in which segmental and non-segmental vitiligo are combined and which is considered a subgroup of vitiligo. Further, the conference recommends that disease stability be best assessed based on the stability of individual lesions rather than the overall stability of the disease as the latter is difficult to define precisely and reliably. The conference also endorsed the classification of KP for vitiligo as proposed by the VETF (history based, clinical observation based, or experimentally induced). Lastly, the conference agreed that 'autoimmune vitiligo' should not be used as a separate classification as published evidence indicates that the pathophysiology of all forms of vitiligo likely involves autoimmune or inflammatory mechanisms. © 2012 John Wiley & Sons A/S.

  17. Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference

    Science.gov (United States)

    Ezzedine, K.; Lim, H. W.; Suzuki, T.; Katayama, I.; Hamzavi, I.; Lan, C. C. E.; Goh, B. K.; Anbar, T.; de Castro, C. Silva; Lee, A. Y.; Parsad, D.; van Geel, N.; Le Poole, I. C.; Oiso, N.; Benzekri, L.; Spritz, R.; Gauthier, Y.; Hann, S. K.; Picardo, M.; Taieb, A.

    2012-01-01

    Summary During the 2011 International Pigment Cell Conference (IPCC), the Vitiligo European Taskforce (VETF) convened a consensus conference on issues of global importance for vitiligo clinical research. As suggested by an international panel of experts, the conference focused on four topics: classification and nomenclature; definition of stable disease; definition of Koebner’s phenomenon (KP); and ‘autoimmune vitiligo’. These topics were discussed in seven working groups representing different geographical regions. A consensus emerged that segmental vitiligo be classified separately from all other forms of vitiligo and that the term ‘vitiligo’ be used as an umbrella term for all non-segmental forms of vitiligo, including ‘mixed vitiligo’ in which segmental and non-segmental vitiligo are combined and which is considered a subgroup of vitiligo. Further, the conference recommends that disease stability be best assessed based on the stability of individual lesions rather than the overall stability of the disease as the latter is difficult to define precisely and reliably. The conference also endorsed the classification of KP for vitiligo as proposed by the VETF (history based, clinical observation based, or experimentally induced). Lastly, the conference agreed that ‘autoimmune vitiligo’ should not be used as a separate classification as published evidence indicates that the pathophysiology of all forms of vitiligo likely involves autoimmune or inflammatory mechanisms. PMID:22417114

  18. Inter-relations between regional and global approaches to nuclear non-proliferation

    International Nuclear Information System (INIS)

    Simpson, J.

    1995-01-01

    It is now becoming evident that the end of the East-West conflict has had a significant effect upon both global and regional security structures. From a situation where regional arrangements were, in the main, determined and driven by pressures arising from the bipolar division which permeated all aspects of the global political system, they increasingly have an independent existence. This has enabled such arrangements to be tailored to local circumstances in a manner which is not possible with global agreements. In particular, it has become apparent that enhanced constraints on peaceful nuclear activities and much more intrusive inspection and monitoring procedures, can more easily be negotiated on a regional basis than a global one. It also appears that nuclear weapon states are prepared to make unconditional commitments about nuclear weapon use on a regional basis, whereas they may not be prepared to do so on a global one. In short, regional approaches enable fine-tuning of the international non-proliferation regime to occur, and for measures to be taken on a regional level that would be politically unacceptable on the global level, due to their discriminatory nature. In the years ahead additional Nuclear-Weapon-Free Zone (NWFZ) agreements may be negotiated, covering more of the land area of the globe. In parallel, regional nuclear cooperation and safeguarding agreements might also be expected to develop along the lines of EURATOM and ABACC. This in turn may move the states which remain outside of the NPT to a similar position to Argentina and Brazil at the moment: to an acceptance that whatever their opposition in principle to the NPT and the system of supplier export guidelines, the commitments they have already accepted on a regional level are more intrusive and constraining than those they would incur if they were to have acceded to the Treaty. In these circumstances, accession to the NPT becomes a distinct possibility, and thus the regional approach to non-proliferation

  19. Trade-related Electronic Commerce Issues in the OECD

    OpenAIRE

    Chang-In Yoon

    1998-01-01

    The trade committee of Organization for Economic Cooperation and Development (OECD) has begun the study of the trade related to electronic commerce since 1997. The scale of the study on one hand has avoided the fact of copy and duplication of WTO and its organizational principles, on the other hand it has played a supplementary and supportive function. At present, digital-related product, such as computers, software and travel is the key point to the trade which resorts to electronic commerce...

  20. Nuclear proliferation and safeguards. Summary

    International Nuclear Information System (INIS)

    1982-03-01

    This comprehensive analysis of the technological, economic, and political factors affecting the potential spread of nuclear weapons proved useful in the congressional debate which culminated in the Nuclear Non-Proliferation Act of 1978. The report was subsequently published commercially and has been a frequently cited reference in the literature on proliferation and nuclear power. Despite developments since 1977, the information in the OTA report is still useful to those wishing to obtain an indepth understanding of the issues. Included is an analysis of why a nation might want nuclear weapons development program and the various sources of nuclear material are discussed. The control of proliferation is considered as well as its relation to the nuclear industry

  1. Current Issues in the Neurology and Genetics of Learning-Related Traits and Disorders: Introduction to the Special Issue.

    Science.gov (United States)

    Gilger, Jeffrey W.

    2001-01-01

    This introductory article briefly describes each of the following eight articles in this special issue on the neurology and genetics of learning related disorders. It notes the greater appreciation of learning disability as a set of complex disorders with broad and intricate neurological bases and of the large individual differences in how these…

  2. Invited review: gender issues related to spaceflight: a NASA perspective

    Science.gov (United States)

    Harm, D. L.; Jennings, R. T.; Meck, J. V.; Powell, M. R.; Putcha, L.; Sams, C. P.; Schneider, S. M.; Shackelford, L. C.; Smith, S. M.; Whitson, P. A.

    2001-01-01

    This minireview provides an overview of known and potential gender differences in physiological responses to spaceflight. The paper covers cardiovascular and exercise physiology, barophysiology and decompression sickness, renal stone risk, immunology, neurovestibular and sensorimotor function, nutrition, pharmacotherapeutics, and reproduction. Potential health and functional impacts associated with the various physiological changes during spaceflight are discussed, and areas needing additional research are highlighted. Historically, studies of physiological responses to microgravity have not been aimed at examining gender-specific differences in the astronaut population. Insufficient data exist in most of the discipline areas at this time to draw valid conclusions about gender-specific differences in astronauts, in part due to the small ratio of women to men. The only astronaut health issue for which a large enough data set exists to allow valid conclusions to be drawn about gender differences is orthostatic intolerance following shuttle missions, in which women have a significantly higher incidence of presyncope during stand tests than do men. The most common observation across disciplines is that individual differences in physiological responses within genders are usually as large as, or larger than, differences between genders. Individual characteristics usually outweigh gender differences per se.

  3. A Survey of Solver-Related Geometry and Meshing Issues

    Science.gov (United States)

    Masters, James; Daniel, Derick; Gudenkauf, Jared; Hine, David; Sideroff, Chris

    2016-01-01

    There is a concern in the computational fluid dynamics community that mesh generation is a significant bottleneck in the CFD workflow. This is one of several papers that will help set the stage for a moderated panel discussion addressing this issue. Although certain general "rules of thumb" and a priori mesh metrics can be used to ensure that some base level of mesh quality is achieved, inadequate consideration is often given to the type of solver or particular flow regime on which the mesh will be utilized. This paper explores how an analyst may want to think differently about a mesh based on considerations such as if a flow is compressible vs. incompressible or hypersonic vs. subsonic or if the solver is node-centered vs. cell-centered. This paper is a high-level investigation intended to provide general insight into how considering the nature of the solver or flow when performing mesh generation has the potential to increase the accuracy and/or robustness of the solution and drive the mesh generation process to a state where it is no longer a hindrance to the analysis process.

  4. Legal issues related to adolescent pregnancy: current concepts.

    Science.gov (United States)

    Rhodes, A M

    1986-09-01

    Adolescent pregnancies have risen in recent years. Options open to the pregnant adolescent are: terminating the pregnancy; giving birth to the child out of wedlock; keeping the baby; giving the baby up for adoption; and marriage before or after the birth of the baby. Each of these options carries certain legal ramifications, since the adolescent patients have not reached the age of majority. The state or the parents usually assume the role of decision making on behalf of the adolescent or assist in the decision making process. Court rulings since the early seventies have legalized abortion and enlarged the rights of minors seeking termination of their pregnancies. Both parents and minors have rights under the certain state laws; parent have the right to notification, minors have the right to privacy. Keeping the child, out of wedlock, might result in legal battles over custody and/or establishing financial support from the father. Some adolescent mothers give up their children for adoption. There are 2 legal procedures that have to be accomplished before a child can be adopted: termination of the rights of the natural parents and adoption proceedings. If the parents marry after the birth of the child, the child is then considered legitimate and the father does not have to go through the process of adopting the child. Other issues requiring parental or individual consent include consent to treatment, contraception, or sterilization. In the case of forcible rape or incest, the physician is required to report incidents to law enforcement officials.

  5. Outcomes in Eyes with Retinal Angiomatous Proliferation in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).

    Science.gov (United States)

    Daniel, Ebenezer; Shaffer, James; Ying, Gui-shuang; Grunwald, Juan E; Martin, Daniel F; Jaffe, Glenn J; Maguire, Maureen G

    2016-03-01

    To compare baseline characteristics, visual acuity (VA), and morphologic outcomes between eyes with retinal angiomatous proliferation (RAP) and all other eyes among patients with neovascular age-related macular degeneration (NVAMD) treated with anti-vascular endothelial growth factor (VEGF) drugs. Prospective cohort study within the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). Patients with NVAMD. Reading center staff evaluated digital color fundus photographs, fluorescein angiography (FA) images, and optical coherence tomography (OCT) scans of eyes with NVAMD treated with either ranibizumab or bevacizumab over a 2-year period. Retinal angiomatous proliferation was identified by the intense intra-retinal leakage of fluorescein in combination with other associated features. Visual acuity; fluorescein leakage; scar; geographic atrophy (GA) on FA; retinal thickness, fluid, and subretinal hyperreflective material (SHRM) on OCT; and the number of intravitreal anti-VEGF injections at 1 and 2 years. Retinal angiomatous proliferation was present in 126 of 1183 (10.7%) study eyes at baseline. Mean VA improvement from baseline was greater (10.6 vs. 6.9 letters; P = 0.01) at 1 year, but similar at 2 years (7.8 vs. 6.2 letters; P = 0.34). At 1 year, eyes with RAP were more likely to have no fluid (46% vs. 26%; P treatment in CATT, eyes with RAP were less likely to have fluid, FA leakage, scar, and SHRM and more likely to have GA than eyes without RAP. Mean improvement in VA was similar at 2 years. Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  6. CBRN and proliferation in Asia

    International Nuclear Information System (INIS)

    Brisset, Jean-Vincent

    2015-01-01

    The author proposes a brief overview of the history, evolution and status of military nuclear weapons and programmes as well as bacteriologic and chemical weapons (nuclear weapons, ballistic missile, and position with respect with the Conventions on chemical and bacteriologic weapons) in Asian countries (China, Japan, India, Pakistan, North Korea). In a second part, he discusses issues related to exports and possible proliferation from these countries

  7. Ethical issues related to biomonitoring studies on children

    DEFF Research Database (Denmark)

    Pedersen, Marie; Merlo, Domenico Franco; Knudsen, Lisbeth E.

    2007-01-01

    Human biomonitoring is a promising tool for assessing environmental exposure and its potential relation with biomarkers, diseases and/or disorders in humans including children. Research with children is essential; however, if the research questions can be resolved by recruitment of adults it is n...

  8. Fuzzy Relational Databases: Representational Issues and Reduction Using Similarity Measures.

    Science.gov (United States)

    Prade, Henri; Testemale, Claudette

    1987-01-01

    Compares and expands upon two approaches to dealing with fuzzy relational databases. The proposed similarity measure is based on a fuzzy Hausdorff distance and estimates the mismatch between two possibility distributions using a reduction process. The consequences of the reduction process on query evaluation are studied. (Author/EM)

  9. Cognitive determinants of energy balance-related behaviours : measurement issues

    NARCIS (Netherlands)

    Kremers, Stef P J; Visscher, Tommy L S; Seidell, Jacob C; van Mechelen, Willem; Brug, Johannes

    2005-01-01

    The burden of disease as a result of overweight and obesity calls for in-depth examination of the main causes of behavioural actions responsible for weight gain. Since weight gain is the result of a positive energy balance, these behavioural actions are referred to as 'energy balance-related

  10. American intergovernmental relations: foundations, perspectives, and issues, 5th ed.

    NARCIS (Netherlands)

    O'Toole, Laurence J.; Christensen, Robert K.

    2012-01-01

    With the addition of brand new co-editor, Robert Christensen, this trusted reader is back in a fresh and insightful fifth edition. To the general structure that has made American Intergovernmental Relations so enduring, the editors have added a new section that incorporates the importance of law and

  11. High energy density physics issues related to Future Circular Collider

    Science.gov (United States)

    Tahir, N. A.; Burkart, F.; Schmidt, R.; Shutov, A.; Wollmann, D.; Piriz, A. R.

    2017-07-01

    A design study for a post-Large Hadron Collider accelerator named, Future Circular Collider (FCC), is being carried out by the International Scientific Community. A complete design report is expected to be ready by spring 2018. The FCC will accelerate two counter rotating beams of 50 TeV protons in a tunnel having a length (circumference) of 100 km. Each beam will be comprised of 10 600 proton bunches, with each bunch having an intensity of 1011 protons. The bunch length is of 0.5 ns, and two neighboring bunches are separated by 25 ns. Although there is an option for 5 ns bunch separation as well, in the present studies, we consider the former case only. The total energy stored in each FCC beam is about 8.5 GJ, which is equivalent to the kinetic energy of Airbus 380 (560 t) flying at a speed of 850 km/h. Machine protection is a very important issue while operating with such powerful beams. It is important to have an estimate of the damage caused to the equipment and accelerator components due to the accidental release of a partial or total beam at a given point. For this purpose, we carried out numerical simulations of full impact of one FCC beam on an extended solid copper target. These simulations have been done employing an energy deposition code, FLUKA, and a two-dimensional hydrodynamic code, BIG2, iteratively. This study shows that although the static range of a single FCC proton and its shower is about 1.5 m in solid copper, the entire beam will penetrate around 350 m into the target. This substantial increase in the range is due to the hydrodynamic tunneling of the beam. Our calculations also show that a large part of the target will be converted into high energy density matter including warm dense matter and strongly coupled plasmas.

  12. Fissile material proliferation risk

    International Nuclear Information System (INIS)

    Dreicer, J.S.; Rutherford, D.A.

    1996-01-01

    The proliferation risk of a facility depends on the material attractiveness, level of safeguards, and physical protection applied to the material in conjunction with an assessment of the impact of the socioeconomic circumstances and threat environment. Proliferation risk is a complementary extension of proliferation resistance. The authors believe a better determination of nuclear proliferation can be achieved by establishing the proliferation risk for facilities that contain nuclear material. Developing a method that incorporates the socioeconomic circumstances and threat environment inherent to each country enables a global proliferation assessment. To effectively reduce the nuclear danger, a broadly based set of criteria is needed that provides the capability to relatively assess a wide range of nuclear related sites and facilities in different countries and still ensure a global decrease in proliferation risk for fissile material (plutonium and highly enriched uranium)

  13. Quality of life issues relating to endocrine treatment options

    DEFF Research Database (Denmark)

    Iversen, P

    1999-01-01

    Recent interest has focused on the use of hormone therapy in prostate cancer for both the management of patients with non-metastatic disease and as a neoadjuvant or adjuvant to curative therapies. This has resulted in patients with fewer symptoms being treated for longer periods of time. Endocrine...... treatments for prostate cancer, such as castration, combined androgen blockade and non-steroidal antiandrogen monotherapy, have shown similar results in terms of time to progression and survival. The main difference between these treatments is their impact on patients' quality of life. Instruments...... for measuring health-related quality of life should assess both overall and disease-specific quality of life. Data from two large studies of bicalutamide monotherapy show that this non-steroidal antiandrogen is associated with significant health-related quality of life advantages in the treatment of patients...

  14. Vestibular and balance issues following sport-related concussion.

    Science.gov (United States)

    Valovich McLeod, Tamara C; Hale, Troy D

    2015-01-01

    To review relevant literature regarding the effect of concussion on vestibular function, impairments, assessments and management strategies. REASONING: Dizziness and balance impairments are common following sport-related concussion. Recommendations regarding the management of sport-related concussion suggest including tests of balance within the multifactorial assessment paradigm for concussive injuries. The literature was searched for guidelines and original studies related to vestibular impairments following concussion, oculomotor and balance assessments and treatment or rehabilitation of vestibular impairments. The databases searched included Medline, CINAHL, Sport Discus and the Cochrane Database of Systematic Reviews through October 2013. Dizziness following concussion occurs in ∼67-77% of cases and has been implicated as a risk factor for a prolonged recovery. Balance impairments also occur after concussion and last 3-10 days post-injury. Assessments of balance can be done using both clinical and instrumented measures with success. Vestibular rehabilitation has been shown to improve outcomes in patients with vestibular impairments, with one study demonstrating success in decreasing symptoms and increasing function following concussion. Best practices suggest that the assessment of vestibular function through cranial nerve, oculomotor and balance assessments are an important aspect of concussion management. Future studies should evaluate the effectiveness of vestibular rehabilitation for improving patient outcomes.

  15. Diffuse colonies of human skin fibroblasts in relation to cellular senescence and proliferation.

    Science.gov (United States)

    Zorin, Vadim; Zorina, Alla; Smetanina, Nadezhda; Kopnin, Pavel; Ozerov, Ivan V; Leonov, Sergey; Isaev, Artur; Klokov, Dmitry; Osipov, Andreyan N

    2017-05-16

    Development of personalized skin treatment in medicine and skin care may benefit from simple and accurate evaluation of the fraction of senescent skin fibroblasts that lost their proliferative capacity. We examined whether enriched analysis of colonies formed by primary human skin fibroblasts, a simple and widely available cellular assay, could reveal correlations with the fraction of senescent cells in heterogenic cell population. We measured fractions of senescence associated β-galactosidase (SA-βgal) positive cells in either mass cultures or colonies of various morphological types (dense, mixed and diffuse) formed by skin fibroblasts from 10 human donors. Although the donors were chosen to be within the same age group (33-54 years), the colony forming efficiency of their fibroblasts (ECO-f) and the percentage of dense, mixed and diffuse colonies varied greatly among the donors. We showed, for the first time, that the SA-βgal positive fraction was the largest in diffuse colonies, confirming that they originated from cells with the least proliferative capacity. The percentage of diffuse colonies was also found to correlate with the SA-βgal positive cells in mass culture. Using Ki67 as a cell proliferation marker, we further demonstrated a strong inverse correlation (r=-0.85, p=0.02) between the percentage of diffuse colonies and the fraction of Ki67+ cells. Moreover, a significant inverse correlation (r=-0.94, p=0.0001) between the percentage of diffuse colonies and ECO-f was found. Our data indicate that quantification of a fraction of diffuse colonies may provide a simple and useful method to evaluate the extent of cellular senescence in human skin fibroblasts.

  16. Statement issued on 30 January 1995 by the Presidency on behalf of the European Union in connection with the accession of Algeria to the Treaty on the Non-Proliferation of Nuclear Weapons

    International Nuclear Information System (INIS)

    1995-01-01

    The statement was issued on 30 January 1995 by the Presidency on behalf of the European Union in connection with Algeria's accession to the Treaty on the Non-Proliferation of Nuclear Weapons. The Statement was received from the Resident Representative of France to the International Atomic Energy Agency and is being circulated for the information of all Member States

  17. Statement issued on 28 February 1995 by the Presidency on behalf of the European Union on accession of Argentina to the Treaty on the Non-Proliferation of Nuclear Weapons

    International Nuclear Information System (INIS)

    1995-01-01

    The statement was issued on 28 February 1995 by the Presidency on behalf of the European Union on accession of Argentina to the Treaty on the Non-Proliferation of Nuclear Weapons. The Statement was received from the Resident Representative of France to the International Atomic Energy Agency and is being circulated for the information of all Member States

  18. Overexpression of Zwint predicts poor prognosis and promotes the proliferation of hepatocellular carcinoma by regulating cell-cycle-related proteins

    Directory of Open Access Journals (Sweden)

    Ying H

    2018-02-01

    Full Text Available Hanning Ying,1,2 Zhiyao Xu,3 Mingming Chen,1,2 Senjun Zhou,1,2 Xiao Liang,1,2 Xiujun Cai1,2 1Department of General Surgery, 2Key Laboratory of Endoscopic Technique Research of Zhejiang Province, 3Central Lab of Biomedical Research Center, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China Introduction: Zwint, a centromere-complex component required for the mitotic spindle checkpoint, has been reported to be overexpressed in different human cancers, but it has not been studied in human hepatocellular carcinoma (HCC.Materials and methods: The role of Zwint in hepatocellular carcinoma cell proliferation capacities was evaluated by using cell counting kit-8 (CCK8, flow cytometry, clone formation and tumor formation assay in nude mice. Western blot analysis and qPCR assay were performed to assess Zwint interacting with cell-cycle-related proteins.Results: We report that ZWINT mRNA and protein expression were upregulated in HCC samples and cell lines. An independent set of 106 HCC-tissue pairs and corresponding noncancerous tissues was evaluated for Zwint expression using immunohistochemistry, and elevated Zwint expression in HCC tissues was significantly correlated with clinicopathological features, such as tumor size and number. Kaplan–Meier survival and Cox regression analysis revealed that high expression of Zwint was correlated with poor overall survival and a greater tendency for tumor recurrence. Ectopic expression of Zwint promoted HCC-cell proliferation, and Zwint expression affected the expression of several cell-cycle proteins, including PCNA, cyclin B1, Cdc25C and CDK1.Conclusion: Our findings suggest that upregulation of Zwint may contribute to the progression of HCC and may be a prognostic biomarker and potential therapeutic target for treating HCC. Keywords: Zwint, hepatocellular carcinoma, HCC, prognosis, cell proliferation, cell cycle

  19. Malaysian public perception towards nuclear power energy-related issues

    Science.gov (United States)

    Misnon, Fauzan Amin; Hu, Yeoh Siong; Rahman, Irman Abd.; Yasir, Muhamad Samudi

    2017-01-01

    Malaysia had considered nuclear energy as an option for future electricity generation during the 9th Malaysia Development Plan. Since 2009, Malaysia had implemented a number of important preparatory steps towards this goal, including the establishment of Nuclear Power Corporation of Malaysia (MNPC) as first Nuclear Energy Programme Implementing Organization (NEPIO) in Malaysia. In light of the establishment of MNPC, the National Nuclear Policy was formulated in 2010 and a new comprehensive nuclear law to replace the existing Atomic Energy Licensing Act (Act 304) is currently in the pipeline. Internationally, public acceptance is generally used to gauge the acceptance of nuclear energy by the public whenever a government decides to engage in nuclear energy. A public survey was conducted in between 14 March 2016 to 10 May 2016 focusing on the Malaysian public acceptance and perception towards the implementation of nuclear energy in Malaysia. The methodology of this research was aim on finding an overview of the general knowledge, public-relation recommendation, perception and acceptance of Malaysian towards the nuclear power development program. The combination of information gathered from this study can be interpreted as an indication of the complexity surrounding the development of nuclear energy and its relationship with the unique background of Malaysian demography. This paper will focus mainly on energy-related section in the survey in comparison with nuclear energy.

  20. Global hydrobelts: improved reporting scale for water-related issues?

    Science.gov (United States)

    Meybeck, M.; Kummu, M.; Dürr, H. H.

    2012-08-01

    Questions related to water such as its availability, water needs or stress, or management, are mapped at various resolutions at the global scale. They are reported at many scales, mostly along political or continental boundaries. As such, they ignore the fundamental heterogeneity of the hydroclimate and the natural boundaries of the river basins. Here, we describe the continental landmasses according to eight global-scale hydrobelts strictly limited by river basins, defined at a 30' (0.5°) resolution. The belts were defined and delineated, based primarily on the annual average temperature (T) and runoff (q), to maximise interbelt differences and minimise intrabelt variability. The belts were further divided into 29 hydroregions based on continental limits. This new global puzzle defines homogeneous and near-contiguous entities with similar hydrological and thermal regimes, glacial and postglacial basin histories, endorheism distribution and sensitivity to climate variations. The Mid-Latitude, Dry and Subtropical belts have northern and southern analogues and a general symmetry can be observed for T and q between them. The Boreal and Equatorial belts are unique. The hydroregions (median size 4.7 Mkm2) contrast strongly, with the average q ranging between 6 and 1393 mm yr-1 and the average T between -9.7 and +26.3 °C. Unlike the hydroclimate, the population density between the North and South belts and between the continents varies greatly, resulting in pronounced differences between the belts with analogues in both hemispheres. The population density ranges from 0.7 to 0.8 p km-2 for the North American Boreal and some Australian hydroregions to 280 p km-2 for the Asian part of the Northern Mid-Latitude belt. The combination of population densities and hydroclimate features results in very specific expressions of water-related characteristics in each of the 29 hydroregions. Our initial tests suggest that hydrobelt and hydroregion divisions are often more

  1. Review: Groundwater resources and related environmental issues in China

    Science.gov (United States)

    Hao, Aibing; Zhang, Yilong; Zhang, Eryong; Li, Zhenghong; Yu, Juan; Wang, Huang; Yang, Jianfeng; Wang, Yao

    2018-05-01

    As an important component of water resources, groundwater plays a crucial role in water utilization in China and an irreplaceable role in supporting economic and social development, especially in the northern arid and semi-arid plains and basin areas, which are densely populated and relatively short of surface-water resources. This paper comprehensively reviews and discusses the regional hydrogeological conditions, the temporal and spatial distribution of groundwater, the groundwater quality, and the actuality of groundwater exploitation and utilization in China. Meanwhile, aiming at the environmental problems induced by overexploitation to meet the sharply increasing water demand, this paper puts forward the major tasks for the next few years in terms of groundwater exploitation control, conservation and management.

  2. Main safety issues related to IPSN severe accident research

    International Nuclear Information System (INIS)

    LeComte, C.

    1991-01-01

    The work performed at IPSN concerning accident studies on nuclear installations is focused on the characterization of accidental sequences with three major aims: prevention, mitigation, and organization of counter-measures. As criteria to optimize all efforts made to improve nuclear safety, the radioactive dispersal in the environment must be quantified as function of internal and external radioactive products transfers. During the short-term phase of the accident, potential radioactive releases can be evaluated by the realistic code system ESCADRE. This system is validated by numerous analytical studies related to containment and fission product behavior. It will be further qualified by the results of the global experiments performed in the PHEBUS FP facility at IPSN

  3. Plan for addressing issues relating to oil shale plant siting

    Energy Technology Data Exchange (ETDEWEB)

    Noridin, J. S.; Donovan, R.; Trudell, L.; Dean, J.; Blevins, A.; Harrington, L. W.; James, R.; Berdan, G.

    1987-09-01

    The Western Research Institute plan for addressing oil shale plant siting methodology calls for identifying the available resources such as oil shale, water, topography and transportation, and human resources. Restrictions on development are addressed: land ownership, land use, water rights, environment, socioeconomics, culture, health and safety, and other institutional restrictions. Descriptions of the technologies for development of oil shale resources are included. The impacts of oil shale development on the environment, socioeconomic structure, water availability, and other conditions are discussed. Finally, the Western Research Institute plan proposes to integrate these topics to develop a flow chart for oil shale plant siting. Western Research Institute has (1) identified relative topics for shale oil plant siting, (2) surveyed both published and unpublished information, and (3) identified data gaps and research needs. 910 refs., 3 figs., 30 tabs.

  4. Some issues related to evidence-based implantology

    Directory of Open Access Journals (Sweden)

    Gunnar E Carlsson

    2016-01-01

    Full Text Available This article reviews relevant dental literature to answer some frequent questions related to evidence-based implantology. There are hundreds of implant systems on the market, but the majority lack clinical documentation. Recommended number of implants for full-arch fixed prostheses is four or five in the mandible but at least six in the maxilla. Less expensive implant-retained overdentures make implant treatment available to a greater portion of edentulous subjects. Mandibular overdentures on two implants, and even one implant, have shown excellent long-term outcomes. In the maxilla, less than four implants are not recommended for good results. Single implant restorations have good prognosis, but placement of the implant should be postponed until adulthood. Osseointegrated implants have revolutionized clinical dentistry. However, in a global perspective, implants make up only a small part of all prosthodontic treatment. Knowledge and skill in conventional prosthodontics must be maintained as it will remain the most common part of the specialty.

  5. Sleep-related Issues for Recovery and Performance in Athletes.

    Science.gov (United States)

    Kölling, Sarah; Duffield, Rob; Erlacher, Daniel; Venter, Ranel; Halson, Shona L

    2018-04-13

    The body of research that reports the relevance of sleep in high-performance sports is growing steadily. While the identification of sleep cycles and diagnosis of sleep disorders is limited to lab-based assessment via polysomnography, the development of activity-based devices estimating sleep patterns provides greater insight into the sleep behaviour of athletes in ecological settings. Overall, small sleep quantity and/or poor quality appears to exist in many athletic populations, though this may be related to training and competition context. Typical sleep-affecting factors are the scheduling of training sessions and competitions as well as impaired sleep-onset as a result of increased arousal prior to competition or due to the use of electronic devices before bedtime. Further challenges are travel demands which may be accompanied by jet-lag symptoms and disruption of sleep habits. Promotion of sleep may be approached via behavioural strategies, such as sleep hygiene, extending night-time sleep or daytime napping. Pharmacological interventions should be limited to clinically-induced treatments as evidence among healthy and athletic populations is lacking. To optimise and manage sleep in athletes, it is recommended to implement routine sleep monitoring on an individual basis.

  6. Breaking bad news: issues relating to nursing practice.

    Science.gov (United States)

    Warnock, Clare

    2014-07-15

    The breaking of bad news was traditionally regarded to be the time when a doctor and nurse sat down with a patient and family members to provide information about, for example, a life-limiting diagnosis or a poor prognosis. However, breaking bad news is now generally accepted as a process, not a one-off event, and is considered to refer to any bad, sad or difficult information that alters patients' perceptions of their present and future. Nurses have an important role in the process of providing information and helping patients prepare for, receive, understand and cope with the bad news they have been given. This article aims to help nurses understand the process of breaking bad news and discuss the challenges and difficulties that nurses can face when they are involved with patients who have been given bad news. It also provides guidance with regard to preparing for breaking bad news, giving difficult information, responding to possible reactions, and supporting patients and their relatives after they have received bad news.

  7. Effect of fenofibrate on oxidative DNA damage and on gene expression related to cell proliferation and apoptosis in rats.

    Science.gov (United States)

    Nishimura, Jihei; Dewa, Yasuaki; Muguruma, Masako; Kuroiwa, Yuichi; Yasuno, Hiroaki; Shima, Tomomi; Jin, Mailan; Takahashi, Miwa; Umemura, Takashi; Mitsumori, Kunitoshi

    2007-05-01

    To investigate the relationship between fenofibrate (FF) and oxidative stress, enzymatic, histopathological, and molecular biological analyses were performed in the liver of male F344 rats fed 2 doses of FF (Experiment 1; 0 and 6000 ppm) for 3 weeks and 3 doses (Experiment 2; 0, 3000, and 6000 ppm) for 9 weeks. FF treatment increased the activity of enzymes such as carnitine acetyltransferase, carnitine palmitoyltransferase, fatty acyl-CoA oxidizing system, and catalase in the liver. However, it decreased those of superoxide dismutase in the liver in both experiments. Increased 8-hydroxy-2'-deoxyguanosine levels in liver DNA and lipofuscin accumulation were observed in the treated rats of Experiment 2. In vitro measurement of reactive oxygen species (ROS) in rat liver microsomes revealed a dose-dependent increase due to FF treatment. Microarray (only Experiment 1) or real-time reverse transcription-polymerase chain reaction analyses revealed that the expression levels of metabolism and DNA repair-related genes such as Aco, Cyp4a1, Cat, Yc2, Gpx2, Apex1, Xrcc5, Mgmt, Mlh1, Gadd45a, and Nbn were increased in FF-treated rats. These results provide evidence of a direct or indirect relationship between oxidative stress and FF treatment. In addition, increases in the expression levels of cell cycle-related genes such as Chek1, Cdc25a, and Ccdn1; increases in the expression levels of cell proliferation-related genes such as Hdgfrp3 and Vegfb; and fluctuations in the expression levels of apoptosis-related genes such as Casp11 and Trp53inp1 were observed in these rats. This suggests that cell proliferation induction, apoptosis suppression, and DNA damage due to oxidative stresses are probably involved in the mechanism of hepatocarcinogenesis due to FF in rats.

  8. 32 CFR 536.35 - Unique issues related to environmental claims.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Unique issues related to environmental claims... issues related to environmental claims. Claims for property damage, personal injury, or death arising in... reported by USARCS to the Environmental Law Division of the Army Litigation Center and the Environmental...

  9. Evaluation of different toxicity assays applied to proliferating cells and to stratified epithelium in relation to permeability enhancement with glycocholate

    DEFF Research Database (Denmark)

    Eirheim, Heidi Ugelstad; Bundgaard, Christoffer; Nielsen, Hanne Mørck

    2004-01-01

    The purpose of the present study was to evaluate different toxicity assays for use on proliferating buccal TR146 cells and on stratified TR146 epithelium and to compare these results to the permeability enhancing effect of glycocholate (GC). Both the proliferating cells and the epithelium were...... across the epithelium concurrent with a decrease in the transepithelial electrical resistance (TEER) was also determined. The robustness of the epithelium was significantly higher than that of the proliferating cells (P...

  10. High glucose concentration induces endothelial cell proliferation by regulating cyclin-D2-related miR-98.

    Science.gov (United States)

    Li, Xin-Xin; Liu, Yue-Mei; Li, You-Jie; Xie, Ning; Yan, Yun-Fei; Chi, Yong-Liang; Zhou, Ling; Xie, Shu-Yang; Wang, Ping-Yu

    2016-06-01

    Cyclin D2 is involved in the pathology of vascular complications of type 2 diabetes mellitus (T2DM). This study investigated the role of cyclin-D2-regulated miRNAs in endothelial cell proliferation of T2DM. Results showed that higher glucose concentration (4.5 g/l) significantly promoted the proliferation of rat aortic endothelial cells (RAOECs), and significantly increased the expression of cyclin D2 and phosphorylation of retinoblastoma 1 (p-RB1) in RAOECs compared with those under low glucose concentration. The cyclin D2-3' untranslated region is targeted by miR-98, as demonstrated by miRNA analysis software. Western blot also confirmed that cyclin D2 and p-RB1 expression was regulated by miR-98. The results indicated that miR-98 treatment can induce RAOEC apoptosis. The suppression of RAOEC growth by miR-98 might be related to regulation of Bcl-2, Bax and Caspase 9 expression. Furthermore, the expression levels of miR-98 decreased in 4.5 g/l glucose-treated cells compared with those treated by low glucose concentration. Similarly, the expression of miR-98 significantly decreased in aortas of established streptozotocin (STZ)-induced diabetic rat model compared with that in control rats; but cyclin D2 and p-RB1 levels remarkably increased in aortas of STZ-induced diabetic rats compared with those in healthy control rats. In conclusion, this study demonstrated that high glucose concentration induces cyclin D2 up-regulation and miR-98 down-regulation in the RAOECs. By regulating cyclin D2, miR-98 can inhibit human endothelial cell growth, thereby providing novel therapeutic targets for vascular complication of T2DM. © 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  11. Control of cell proliferation, endoreduplication, cell size, and cell death by the retinoblastoma-related pathway in maize endosperm

    KAUST Repository

    Sabelli, Paolo A.

    2013-04-22

    The endospermof cereal grains is one of the most valuable products of modern agriculture. Cereal endosperm development comprises different phases characterized by mitotic cell proliferation, endoreduplication, the accumulation of storage compounds, and programmed cell death. Although manipulation of these processes could maximize grain yield, how they are regulated and integrated is poorly understood. We show that the Retinoblastoma-related (RBR) pathway controls key aspects of endosperm development in maize. Down-regulation of RBR1 by RNAi resulted in up-regulation of RBR3-type genes, as well as the MINICHROMOSOME MAINTENANCE 2-7 gene family and PROLIFERATING CELL NUCLEAR ANTIGEN, which encode essential DNA replication factors. Both the mitotic and endoreduplication cell cycles were stimulated. Developing transgenic endosperm contained 42-58% more cells and ~70% more DNA than wild type, whereas there was a reduction in cell and nuclear sizes. In addition, cell death was enhanced. The DNA content of mature endosperm increased 43% upon RBR1 downregulation, whereas storage protein content and kernel weight were essentially not affected. Down-regulation of both RBR1 and CYCLIN DEPENDENT KINASE A (CDKA);1 indicated that CDKA;1 is epistatic to RBR1 and controls endoreduplication through an RBR1- dependent pathway. However, the repressive activity of RBR1 on downstream targets was independent from CDKA;1, suggesting diversification of RBR1 activities. Furthermore, RBR1 negatively regulated CDK activity, suggesting the presence of a feedback loop. These results indicate that the RBR1 pathway plays a major role in regulation of different processes during maize endosperm development and suggest the presence of tissue/organlevel regulation of endosperm/seed homeostasis.

  12. Assessment of combustion and related issues in the DWPF and ITP waste tanks

    International Nuclear Information System (INIS)

    Ginsberg, T.

    1994-04-01

    This report presents a review of the safety analyses described in the DWPF Safety Analysis Report, the combustion analysis of the ITP Tanks 48 and 49, and presents conclusions drawn from interviews staff on issues related to accident analysis, in particular on issues related to combustion phenomena. The major objectives of this report are to clarify the issues related to the modes of combustion and expected loads on process vessels and structures and, in addition, to offer recommendations which would improve the defense-in-depth posture of the DWPF

  13. Giftedness Counseling in Germany: Consultation Reasons and Issues and Their Relations to Gender, Age, and Aptitude

    Science.gov (United States)

    Hannig, Nele; Koop, Christine

    2016-01-01

    In Germany, parents can request counseling and assessment of school-related learning and behavioral issues from either independent counseling centers or school-based ones. Focusing on giftedness consultations at independent counseling centers, the goal of this study is to provide a detailed description of the reasons for and the issues discussed…

  14. Some critical issues in special needs education as they relate to ...

    African Journals Online (AJOL)

    The study examines five critical issues in special education as they relate to visual impairment vis a vis mercy killing (euthanasia), gender, seclusion, castration and genetic engineering. Literature in the five stated issues was reviewed to provide an insight into these areas with particular reference to visual impairment.

  15. China-U.S. Relations: Current Issues and Implications for U.S. Policy

    National Research Council Canada - National Science Library

    Dumbaugh, Kerry

    2007-01-01

    .... policy makers have adopted tougher stances on issues involving China and U.S.-China relations, concerned about the impact of the PRC's strong economic growth and a more assertive international diplomacy...

  16. 75 FR 64710 - Joint Public Roundtable on Issues Related to the Clearing of Credit Default Swaps

    Science.gov (United States)

    2010-10-20

    ... certain issues related to the clearing of Credit Default Swaps in the context of the Agencies rulemaking... comments must be in English or be accompanied by an English translation. All submissions provided to either...

  17. Information Operations, Electronic Warfare, and Cyberwar: Capabilities and Related Policy Issues

    National Research Council Canada - National Science Library

    Wilson, Clay

    2007-01-01

    .... It also suggests related policy issues of potential interest to Congress. For military planners, the control of information is critical to military success, and communications networks and computers are of vital operational importance...

  18. Nuclear Proliferation Technology Trends Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Zentner, Michael D.; Coles, Garill A.; Talbert, Robert J.

    2005-10-04

    A process is underway to develop mature, integrated methodologies to address nonproliferation issues. A variety of methodologies (both qualitative and quantitative) are being considered. All have one thing in common, a need for a consistent set of proliferation related data that can be used as a basis for application. One approach to providing a basis for predicting and evaluating future proliferation events is to understand past proliferation events, that is, the different paths that have actually been taken to acquire or attempt to acquire special nuclear material. In order to provide this information, this report describing previous material acquisition activities (obtained from open source material) has been prepared. This report describes how, based on an evaluation of historical trends in nuclear technology development, conclusions can be reached concerning: (1) The length of time it takes to acquire a technology; (2) The length of time it takes for production of special nuclear material to begin; and (3) The type of approaches taken for acquiring the technology. In addition to examining time constants, the report is intended to provide information that could be used to support the use of the different non-proliferation analysis methodologies. Accordingly, each section includes: (1) Technology description; (2) Technology origin; (3) Basic theory; (4) Important components/materials; (5) Technology development; (6) Technological difficulties involved in use; (7) Changes/improvements in technology; (8) Countries that have used/attempted to use the technology; (9) Technology Information; (10) Acquisition approaches; (11) Time constants for technology development; and (12) Required Concurrent Technologies.

  19. Non proliferation of nuclear weapons?

    International Nuclear Information System (INIS)

    Le Guelte, Georges

    2015-10-01

    After having evoked the behaviour of nuclear countries regarding the development of nuclear weapons and uranium procurement, or nuclear programmes after the Second World War until nowadays, the author presents the non proliferation Treaty (NPT) as a construction at the service of super-powers. He comments and discusses the role of the IAEA control system and its evolutions: a control limited to declared installations, an export control with the spectre of plutonium, a control system thwarted by some technological innovations, information systems coming in, and an additional protocol related to the application of guarantees. He comments the evolution of the context from a bipolar world to a world without pole which raises the issue of how to have commitments respected: description of the role and practice of non proliferation during the Cold War, after the Cold War, and in a world without governance

  20. Androgen-independent proliferation of LNCaP prostate cancer cells infected by xenotropic murine leukemia virus-related virus

    International Nuclear Information System (INIS)

    Kakoki, Katsura; Kamiyama, Haruka; Izumida, Mai; Yashima, Yuka; Hayashi, Hideki; Yamamoto, Naoki; Matsuyama, Toshifumi; Igawa, Tsukasa; Sakai, Hideki; Kubo, Yoshinao

    2014-01-01

    Highlights: • XMRV infection induces androgen-independent growth in LNCaP cells. • XMRV infection reduces expression of androgen receptor. • XMRV promotes appearance of androgen blocker-resistant prostate cancer cells. - Abstract: Xenotropic murine leukemia virus-related virus (XMRV) is a novel gammaretrovirus that was originally isolated from human prostate cancer. It is now believed that XMRV is not the etiologic agent of prostate cancer. An analysis of murine leukemia virus (MLV) infection in various human cell lines revealed that prostate cancer cell lines are preferentially infected by XMRV, and this suggested that XMRV infection may confer some sort of growth advantage to prostate cancer cell lines. To examine this hypothesis, androgen-dependent LNCaP cells were infected with XMRV and tested for changes in certain cell growth properties. We found that XMRV-infected LNCaP cells can proliferate in the absence of the androgen dihydrotestosterone. Moreover, androgen receptor expression is significantly reduced in XMRV-infected LNCaP cells. Such alterations were not observed in uninfected and amphotropic MLV-infected LNCaP cells. This finding explains why prostate cancer cell lines are preferentially infected with XMRV

  1. Role of trace metals in cell proliferation in the human neuroblastoma: relations with the oncogene N-myc

    International Nuclear Information System (INIS)

    Moretto, Ph.; Michelet, C.; Gouget, B.; Ortega, R.; Sergiant, C.; Llabador, Y.; Simonoff, M.; Benard, J.

    1997-01-01

    Neuroblastoma is one of the most common tumors in young children. Iron is known to be necessary for cellular proliferation. Several studies have suggested that neuroblastoma cells appear to be relatively sensitive to growth inhibition by specific Fe chelators, in vitro. In addition, it appeared that an increased serum ferritin level at diagnosis was associated with a poorer outcome than a normal level. On the other hand it was reported that untreated primary neuroblastoma had multiple copies of the N-myc oncogene. A significant association between genomic amplification and rapid tumor progression after diagnosis has been demonstrated. In order to study the relationship between iron N-myc amplification, we propose to determine the trace metal content of neuroblastoma cells. Preliminary results obtained with two distinct cell lines: SK-N-SH, a neuroblastoma cell line with a single copy of N-myc and IGR-N-91, a metastatic cell line exhibiting 60 copies of N-myc are presented. (authors)

  2. Selected legal and institutional issues related to Ocean Thermal Energy Conversion (OTEC) development

    Energy Technology Data Exchange (ETDEWEB)

    Nanda, V. P.

    1979-06-01

    Ocean Thermal Energy Conversion (OTEC), an attractive alternative to traditional energy sources, is still in the early stages of development. To facilitate OTEC commercialization, it is essential that a legal and institutional framework be designed now so as to resolve uncertainties related to OTEC development, primarily involving jurisdictional, regulatory, and environmental issues. The jurisdictional issues raised by OTEC use are dependent upon the site of an OTEC facility and its configuration; i.e., whether the plant is a semipermanent fixture located offshore or a migrating plant ship that provides a source of energy for industry at sea. These issues primarily involve the division of authority between the Federal Government and the individual coastal states. The regulatory issues raised are largely speculative: they involve the adaptation of existing mechanisms to OTEC operation. Finally, the environmental issues raised center around compliance with the National Environmental Policy Act (NEPA) as well as international agreements. 288 references.

  3. Multiple system responses program: Identification of concerns related to a number of specific regulatory issues

    International Nuclear Information System (INIS)

    Murphy, G.A.; Casada, M.L.; Palko, L.E.; Roberts, M.W.

    1989-10-01

    This document describes the activities and results of the Multiple System Responses (MSR) program conducted by the Nuclear Operations Analysis Center (NOAC) at Oak Ridge National Laboratory (ORNL). The objective of the MSR program was to gather and review documentation for several unresolved safety issues and related programs of interest, and from that documentation, describe any additional potential safety concerns. The MSR program provides information that will aid the NRC staff in making an assessment of the relative safety significance of the concerns through the established prioritization process. Judgments were not made regarding the validity of the concerns expressed by others. Rather, the concerns were documented and potential safety issues were developed and defined as specifically as possible. Twenty-one potential safety issues were developed from the documented concerns. Additional information was gathered to support the NRC efforts in reviewing these issues for prioritization. 73 refs., 2 tabs

  4. Popper and Dingle on special relativity and the issue of symmetry

    Science.gov (United States)

    Dotson, Allen Clark

    2012-02-01

    Karl Popper and Herbert Dingle engaged in a fascinating debate concerning the kind of theory the special theory of relativity is. One of the issues was whether applications of the theory could be made consistent with the principle of relativity, a cornerstone of the theory itself. The principle of relativity seems to imply some sort of symmetry in results obtained for similar experiments as observed in two different inertial reference frames. Peter Hayes has recently dealt with the Dingle-Popper debate on this matter, as well as other issues. The present paper seeks to clarify what kind of symmetry is appropriate in a situation discussed by Popper, Dingle, and Hayes.

  5. Information Retrieval System Design Issues in a Microcomputer-Based Relational DBMS Environment.

    Science.gov (United States)

    Wolfram, Dietmar

    1992-01-01

    Outlines the file structure requirements for a microcomputer-based information retrieval system using FoxPro, a relational database management system (DBMS). Issues relating to the design and implementation of such systems are discussed, and two possible designs are examined in terms of space economy and practicality of implementation. (15…

  6. University Intervention into Community Issues as Dialogic Public Relations: A Case Study

    Science.gov (United States)

    Byrne, Jamie M.

    2007-01-01

    This paper examines a study of the wastewater collection and treatment issues of Little Rock and North Little Rock, Arkansas by University of Arkansas at Little Rock personnel and how it constitutes dialogic public relations. The paper defines dialogic public relations using Kent and Taylor's work and then uses their criteria to describe how this…

  7. 76 FR 52731 - On-Line Complaint Form for Service-Related Issues in Air Transportation

    Science.gov (United States)

    2011-08-23

    ... for Service-Related Issues in Air Transportation AGENCY: Office of the Secretary, Department of... consumer protection and civil rights laws and regulations related to air transportation. The Enforcement... travelers, and to ensure safe and adequate service in air transportation. Filing a complaint using a web...

  8. Introduction to the Special Issue: New and Interdisciplinary Approaches to Linguistic Relativity

    Science.gov (United States)

    Athanasopoulos, Panos; Bylund, Emanuel; Casasanto, Daniel

    2016-01-01

    This Special Issue of "Language Learning" presents an interdisciplinary state-of-the-art overview of current approaches to linguistic relativity. It contains empirical and theoretical studies and reflections on linguistic relativity from a variety of perspectives, such as associative learning, conceptual transfer, multilingual awareness,…

  9. Difficulties are multiplying - topical legal issues relating to nuclear waste disposal

    International Nuclear Information System (INIS)

    Strassburg, W.

    1985-01-01

    The report points out topical legal issues relating to nuclear waste disposal, yet leaves no doubt that the technical-scientific concept for nuclear waste disposal incorporated into the nuclear energy law in 1976 was a success. Nonetheless it is desirable that there should be persistent efforts especially on the part of parliament when issuing legislation or statutory orders to reach greater clearness and thus predictability in areas where technology has been proven by many years of practice. (orig./HSCH) [de

  10. THE PRACTICE OF ECT IN INDIA : ISSUES RELATING YO THE ADMINISTRATION OF ECT

    OpenAIRE

    Agarwal, A.K.; Andrade, Chittaranjan; Reddy, M. Venkataswamy

    1992-01-01

    A questionnaire on ECT, tapping altitudes, opinions and usage, was mailed to all medical members of the Indian Psychiatric Society whose addresses were known; 263 (28.8%) responded. This paper, the first in a series that presents the results of the survey, provides demographic data on the respondents and covers issues relating to the administration of ECT. Specific issues discussed include the ECT personnel, location of the ECT facility, certain ECT prescription patterns, psychiatrist-patient...

  11. Analysis of the presence of cell proliferation-related molecules in the Tgf-β3 null mutant mouse palate reveals misexpression of EGF and Msx-1.

    Science.gov (United States)

    del Río, A; Barrio, M C; Murillo, J; Maldonado, E; López-Gordillo, Y; Martínez-Sanz, E; Martínez, M L; Martínez-Álvarez, C

    2011-01-01

    The Tgf-β(3) null mutant mouse palate presents several cellular anomalies that lead to the appearance of cleft palate. One of them concerns the cell proliferation of both the palatal medial edge epithelium and mesenchyme. In this work, our aim was to determine whether there was any variation in the presence/distribution of several cell proliferation-related molecules that could be responsible for the cell proliferation defects observed in these palates. Our results showed no difference in the presence of EGF-R, PDGF-A, TGF-β(2), Bmp-2, and Bmp-4, and differences were minimal for FGF-10 and Shh. However, the expression of EGF and Msx-1 changed substantially. The shift of the EGF protein expression was the one that most correlated with that of cell proliferation. This molecule is regulated by TGF-β(3), and experiments blocking its activity in culture suggest that EGF misexpression in the Tgf-β(3) null mutant mouse palate plays a role in the cell proliferation defect observed. Copyright © 2010 S. Karger AG, Basel.

  12. Cellular uptake of {sup 99m}TcN-NOET in human leukaemic HL-60 cells is related to calcium channel activation and cell proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Guillermet, Stephanie; Vuillez, Jean-Philippe; Caravel, Jean-Pierre; Marti-Batlle, Daniele; Fagret, Daniel [Universite de Grenoble, Radiopharmaceutiques Biocliniques, La Tronche (France); Fontaine, Eric [Universite de Grenoble, Laboratoire de Bioenergetique Fondamentale et Appliquee, Grenoble (France); Pasqualini, Roberto [Cis Bio International Schering SA, Gif-sur-Yvette (France)

    2006-01-01

    A major goal of nuclear oncology is the development of new radiolabelled tracers as proliferation markers. Intracellular calcium waves play a fundamental role in the course of the cell cycle. These waves occur in non-excitable tumour cells via store-operated calcium channels (SOCCs). Bis(N-ethoxy, N-ethyldithiocarbamato) nitrido technetium (V)-99m ({sup 99m}TcN-NOET) has been shown to interact with L-type voltage-operated calcium channels (VOCCs) in cultured cardiomyocytes. Considering the analogy between VOCCs and SOCCs, we sought to determine whether {sup 99m}TcN-NOET also binds to activated SOCCs in tumour cells in order to clarify the potential value of this tracer as a proliferation marker. Uptake kinetics of {sup 99m}TcN-NOET were measured in human leukaemic HL-60 cells over 60 min and the effect of several calcium channel modulators on 1-min tracer uptake was studied. The uptake kinetics of {sup 99m}TcN-NOET were compared both with the variations of cytosolic free calcium concentration measured by indo-1/AM and with the variations in the SG{sub 2}M cellular proliferation index. All calcium channel inhibitors significantly decreased the cellular uptake of {sup 99m}TcN-NOET whereas the activator thapsigargin induced a significant 10% increase. In parallel, SOCC activation by thapsigargin, as measured using the indo-1/AM probe, was inhibited by nicardipine. These results indicate that the uptake of {sup 99m}TcN-NOET is related to the activation of SOCCs. Finally, a correlation was observed between the tracer uptake and variations in the proliferation index SG{sub 2}M. The uptake of {sup 99m}TcN-NOET seems to be related to SOCC activation and to cell proliferation in HL-60 cells. These results indicate that {sup 99m}TcN-NOET might be a marker of cell proliferation. (orig.)

  13. Cellular uptake of 99mTcN-NOET in human leukaemic HL-60 cells is related to calcium channel activation and cell proliferation

    International Nuclear Information System (INIS)

    Guillermet, Stephanie; Vuillez, Jean-Philippe; Caravel, Jean-Pierre; Marti-Batlle, Daniele; Fagret, Daniel; Fontaine, Eric; Pasqualini, Roberto

    2006-01-01

    A major goal of nuclear oncology is the development of new radiolabelled tracers as proliferation markers. Intracellular calcium waves play a fundamental role in the course of the cell cycle. These waves occur in non-excitable tumour cells via store-operated calcium channels (SOCCs). Bis(N-ethoxy, N-ethyldithiocarbamato) nitrido technetium (V)-99m ( 99m TcN-NOET) has been shown to interact with L-type voltage-operated calcium channels (VOCCs) in cultured cardiomyocytes. Considering the analogy between VOCCs and SOCCs, we sought to determine whether 99m TcN-NOET also binds to activated SOCCs in tumour cells in order to clarify the potential value of this tracer as a proliferation marker. Uptake kinetics of 99m TcN-NOET were measured in human leukaemic HL-60 cells over 60 min and the effect of several calcium channel modulators on 1-min tracer uptake was studied. The uptake kinetics of 99m TcN-NOET were compared both with the variations of cytosolic free calcium concentration measured by indo-1/AM and with the variations in the SG 2 M cellular proliferation index. All calcium channel inhibitors significantly decreased the cellular uptake of 99m TcN-NOET whereas the activator thapsigargin induced a significant 10% increase. In parallel, SOCC activation by thapsigargin, as measured using the indo-1/AM probe, was inhibited by nicardipine. These results indicate that the uptake of 99m TcN-NOET is related to the activation of SOCCs. Finally, a correlation was observed between the tracer uptake and variations in the proliferation index SG 2 M. The uptake of 99m TcN-NOET seems to be related to SOCC activation and to cell proliferation in HL-60 cells. These results indicate that 99m TcN-NOET might be a marker of cell proliferation. (orig.)

  14. Nuclear proliferation and the near-nuclear countries

    International Nuclear Information System (INIS)

    Marwah, O.; Schulz, A.

    1975-01-01

    The process of nuclear proliferation and its consequences for the international political system is examined by focusing on the issues in the nuclear-strategic debate that divide first and second order states. Information is included on: the US-USSR arms race; SALT agreement; the Non-Proliferation Treaty; the nuclear aspirations and policies of India, Middle Eastern countries, South Africa, Japan, Brazil, and Argentina; and assessment of the risks related to the nuclear fuel cycle and nuclear weapons

  15. Containment-emergency-sump performance. Technical findings related to Unresolved Safety Issue A-43

    International Nuclear Information System (INIS)

    1983-04-01

    This report summarizes key technical findings related to the Unresolved Safety Issue A-43, Containment Emergency Sump Performance, and provides recommendations for resolution of attendant safety issues. The key safety questions relate to: (a) effects of insulation debris on sump performance; (b) sump hydraulic performance as determined by design features, submergence, and plant induced effects, and (c) recirculation pump performance wherein air and/or particulate ingestion can occur. The technical findings presented in this report provide information relevant to the design and performance evaluation of the containment emergency sump

  16. 75 FR 62514 - Notice of Availability of Report on Data Access and Privacy Issues Related to Smart Grid...

    Science.gov (United States)

    2010-10-12

    ... DEPARTMENT OF ENERGY Notice of Availability of Report on Data Access and Privacy Issues Related to... report entitled, ``Data Access and Privacy Issues Related to Smart Grid Technologies.'' In this report... report entitled, ``Data Access and Privacy Issues Related to Smart Grid Technologies,'' DOE considered...

  17. Framing Islam-related issues during GE13: An analysis of Malaysian mainstream newspapers

    Directory of Open Access Journals (Sweden)

    Aini Maznina A.Manaf

    2015-06-01

    Full Text Available Abstract: The two major political coalitions in Malaysia are Barisan Nasional  (BN and Pakatan Rakyat (PR, which are dominated by the Malay-Muslim majority. During the 13th national election, to gain public votes, the government used mainstream newspapers to frame Islam-related issues. This research focuses on the characterisation and information reported about Islam and Muslims during the 13th General Election. Using content analysis, we examine the coverage of such issues by the mainstream newspapers: Berita Harian, Utusan Malaysia, New Straits Times, and The Star. This analysis aims to provide a holistic review of the scope of the coverage during the period with a focus on how the Malaysian government framed Islam-related issues through the print media in order to gain the Malay votes. A total of 178 news articles were analysed, from which we found that 15 dominant issues were reported in the newspapers during that period. Among the most frequently reported Islam-related issues were hudud (prescribed punishments, Islamic state, and kalimah Allah (the word “Allah”, which were predominantly covered by the Malay newspapers. In addition, the data indicated that most of the news were inclined towards supporting the ruling coalition, i.e., Barisan Nasional.

  18. Love versus abuse: crossgenerational sexual relations of minors: a gay rights issue?

    Science.gov (United States)

    Graupner, H

    1999-01-01

    The question discussed is how far crossgenerational sexual relations with or by minors could be considered to be a gay rights issue. The author discusses the issue from the perspective of general principles found in the case-law of the European Court on Human Rights. These principles suggest that the basic right to privacy should be interpreted as providing comprehensive protection of the right of children and adolescents to sexual self-determination, namely both the right to effective protection from (unwanted) sex and abuse on the one hand and the right to (wanted) sex on the other. The analysis is based upon the findings of natural and social science as well as an extensive international survey of national legal provisions and it leads to the conclusion that consensual sexual relations of and with adolescents over 14 (out of relations of authority) should be qualified a gay rights issue; likewise (as the exception to the rule) the possibility of filtering out cases from prosecution where a contact/relation is proven (beyond reasonable doubt) as consensual and harmless even though the minor involved is under 14. The legalization of (objectively consensual) sexual relations with persons under 14 as such, however, should not be considered to be a gay rights issue.

  19. Patients' Perspectives on Information and Communication About Sexual and Relational Issues in Rheumatology Health Care.

    Science.gov (United States)

    Helland, Ylva; Dagfinrud, Hanne; Haugen, Mona-Iren; Kjeken, Ingvild; Zangi, Heidi

    2017-06-01

    Men and women with rheumatic diseases report a significantly negative impact on multiple areas of life, including sexuality. Research indicates that patients want to discuss sexual issues with health professionals (HPs) in rheumatology care but these issues are rarely addressed in consultations. The objective of the present study was to explore patients' experiences of communication with HPs about disease-related sexual issues, their perceptions of the relevance of these issues in rheumatology care and their preferences for how these topics should be handled. A qualitative design was used and 18 semi-structured interviews were performed, including eight women and ten men with inflammatory rheumatic joint diseases, aged 29-62 years. The interviews were recorded and transcribed verbatim. Data were analysed thematically. Four main themes were derived from the interviews: (i) relevance of sexual issues; (ii) vital conditions for communication; (iii) individual preferences in mode and timing of information and communication; and (iv) benefits of information and communication. The participants expressed that, although sexual issues are relevant, necessary conditions for good communication are largely lacking. HPs' knowledge, experience and personal skills, as well as having sufficient time were essential. HPs lack of initiating sexual topics contributed to uncertainty about whether their sexual challenges were disease related and whether it was a legitimate topic to discuss in rheumatology care. Patients wanted HPs to possess knowledge about possible disease-related challenges in sexual life and intimate relationships, and to facilitate communication about these aspects. There is a need to develop practice guidelines to enable HPs to integrate sexual issues as an aspect of healthcare delivery in a patient-friendly manner. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  20. In vitro invasion efficiency and intracellular proliferation rate comprise virulence-related phenotypic traits of Neospora caninum

    Directory of Open Access Journals (Sweden)

    Regidor-Cerrillo Javier

    2011-02-01

    Full Text Available Abstract In this study, we examined the in vitro invasion and proliferation capacities of the Nc-Liv and ten Spanish Neospora caninum isolates (Nc-Spain 1 H - Nc-Spain 10. The invasion rate was determined as the number of tachyzoites that completed their internalisation into MARC-145 cells at 2, 4, and 6 h post-inoculation (pi. The proliferation rate was evaluated by determining the doubling time during the exponential proliferation period. Significant differences in the invasion rates of these isolates were detected at 2 and 4 h pi (P P = 0.0016, ANOVA test. Tachyzoite yield, which combines invasion and proliferation data, was also assessed and confirmed marked differences between the highly and less prolific isolates. Interestingly, a direct correlation between the invasion rates and tachyzoite yields, and the severity of the disease that was exhibited by infected pregnant mice in previous works could be established for the isolates in this study (Spearman's coefficient > 0.62, P

  1. Environmental issues related to commercialization of CulnSe{sub 2}- based photovoltaics

    Energy Technology Data Exchange (ETDEWEB)

    Eberspacher, C. [UNISUN, Newbury Park, CA (United States); Fthenakis, V.M.; Moskowitz, P.D.

    1996-07-01

    One of the most promising materials for low-cost thin film photovoltaic cells is copper indium selenide (CuInSe{sub 2} or CIS). As with any new material, successful commercialization of CIS photovoltaic (PV) technology will require attention to environmental issues related to the sources of raw materials, their usage, and the disposal and/or recycling of products at the end of their useful life. This paper focuses on three specific environmental issues related to CIS technology: (i) Economics of the use and re-use of materials; (ii) regulations on environmental disposal and waste handling, and (iii) logistics and economics of recycling and disposing of products by industries faced with comparable environmental issues.

  2. Environmental issues related to commercialization of CulnSe2- based photovoltaics

    International Nuclear Information System (INIS)

    Eberspacher, C.; Fthenakis, V.M.; Moskowitz, P.D.

    1996-01-01

    One of the most promising materials for low-cost thin film photovoltaic cells is copper indium selenide (CuInSe 2 or CIS). As with any new material, successful commercialization of CIS photovoltaic (PV) technology will require attention to environmental issues related to the sources of raw materials, their usage, and the disposal and/or recycling of products at the end of their useful life. This paper focuses on three specific environmental issues related to CIS technology: (i) Economics of the use and re-use of materials; (ii) regulations on environmental disposal and waste handling, and (iii) logistics and economics of recycling and disposing of products by industries faced with comparable environmental issues

  3. The Asilomar Survey: Stakeholders' Opinions on Ethical Issues Related to Brain-Computer Interfacing.

    Science.gov (United States)

    Nijboer, Femke; Clausen, Jens; Allison, Brendan Z; Haselager, Pim

    2013-01-01

    Brain-Computer Interface (BCI) research and (future) applications raise important ethical issues that need to be addressed to promote societal acceptance and adequate policies. Here we report on a survey we conducted among 145 BCI researchers at the 4 th International BCI conference, which took place in May-June 2010 in Asilomar, California. We assessed respondents' opinions about a number of topics. First, we investigated preferences for terminology and definitions relating to BCIs. Second, we assessed respondents' expectations on the marketability of different BCI applications (BCIs for healthy people, BCIs for assistive technology, BCIs-controlled neuroprostheses and BCIs as therapy tools). Third, we investigated opinions about ethical issues related to BCI research for the development of assistive technology: informed consent process with locked-in patients, risk-benefit analyses, team responsibility, consequences of BCI on patients' and families' lives, liability and personal identity and interaction with the media. Finally, we asked respondents which issues are urgent in BCI research.

  4. Complexities in gauging time-dependency of proliferation resistance

    International Nuclear Information System (INIS)

    Avens, L.R.; Eller, P.G.; Stanbro, W.D.

    2004-01-01

    To a considerable extent, policy decisions on nuclear fuel cycle issues depend upon how decision makers recognize and weigh 'long-term' and 'short-term' nuclear proliferation risk factors. Priorities and structures of advanced fuel cycle and safeguards research and development programs are affected similarly. Unfortunately, there is a diversity of understanding of the precise meanings of these proliferation risk terms, leading to lack of precision in their usage. In addition, proliferation risk evaluation fundamentally involves value judgments on the relative importance of time-dependent risks. Poor communication and diverse conclusions often result. This paper explores some complexities in gauging 'long-term' and 'short-term' proliferation risk in the context of advanced nuclear fuel cycles. A convenient vehicle for this purpose is a commonly used notional plot of some proliferation resistance attribute of spent fuel or separated plutonium versus years from reactor discharge, often overlain with similar notional curves denoting multiple fuel irradiation and recycle. A common basis for misuse of such plots is failure to clearly define the range of proliferation threats being evaluated, as illustrated by several common examples of such omissions. Partial arguments of this type can be misleading and provide a disservice to policy makers who must have a clear picture of the tradeoffs being made. This paper concludes with a call for much greater care to avoid overly simplistic interpretations of notional proliferation-related concepts and greater precision in general in use of proliferation-related terminology.

  5. Leukemia inhibitory factor increases the proliferation of human endometrial stromal cells and expression of genes related to pluripotency

    Directory of Open Access Journals (Sweden)

    Mojdeh Salehnia

    2017-08-01

    Full Text Available Background: Concerning the low population of human endometrial mesenchymal cells within the tissue and their potential application in the clinic and tissue engineering, some researches have been focused on their in vitro expansion. Objective: The aim of this study was to evaluate the effect of leukemia inhibitory factor (LIF as a proliferative factor on the expansion and proliferation of human endometrial stromal cells. Materials and Methods: In this experimental study, the isolated and cultured human endometrial stromal cells from women at ovulatory phase aged 20-35 years, after fourth passage were divided into control and LIF-treated groups. In the experimental group, the endometrial cells were treated by 10 ng/ml LIF in culture media and the cultured cells without adding LIF considered as control group. Both groups were evaluated and compared for proliferation rate using MTT assay, for CD90 marker by flow cytometric analysis and for the expression of Oct4, Nanog, PCNA and LIFr genes using real-time RT-PCR. Results: The proliferation rate of control and LIF-treated groups were 1.17±0.17 and 1.61±0.06 respectively and there was a significant increase in endometrial stromal cell proliferation following in vitro treatment by LIF compared to control group (p=0.049. The rate of CD90 positive cells was significantly increased in LIFtreated group (98.96±0.37% compared to control group (94.26±0.08% (p=0.0498. Also, the expression ratio of all studied genes was significantly increased in the LIFtreated group compared to control group (p=0.0479. Conclusion: The present study showed that LIF has a great impact on proliferation, survival, and maintenance of pluripotency of human endometrial stromal cells and it could be applicable in cell therapies.

  6. Key issues of public relations of Europe: findings from the European Communication Monitor 2007-2014

    NARCIS (Netherlands)

    Verčič, D.; Verhoeven, P.; Zerfass, A.

    2014-01-01

    European Communication Monitor is the largest longitudinal research project in public relations practice in the world. Data collected annually from 2007 to 2014 show that practitioners perceive five issues as the most important for their work: linking business strategy and communication, coping with

  7. Introducing GaLA: Serious Game potentials, challenges and TEL-related issues

    NARCIS (Netherlands)

    Earp, Jeffrey; Klemke, Roland

    2011-01-01

    Earp, J., & Klemke, R. (2011, 21 September). Introducing GaLA: Serious Game potentials, challenges and TEL-related issues. Presented at TEL-Think-Tank Workshop at the 6th European conference on Technology enhanced learning: towards ubiquitous learning (EC-TEL 2011), Palermo, Italy.

  8. Allostatic Load: Single Parents, Stress-Related Health Issues, and Social Care

    Science.gov (United States)

    Johner, Randy L.

    2007-01-01

    This article explores the possible relationships between allostatic load (AL) and stress-related health issues in the low-income single-parent population, using both a population health perspective (PHP) and a biological framework. A PHP identifies associations among such factors as gender, income, employment, and social support and their…

  9. How Do Learners in Developed and Developing Countries Relate to Environmental Issues?

    Science.gov (United States)

    Trumper, Ricardo

    2010-01-01

    The present study was carried out in the framework of earlier research on environmental education for sustainability, using data collected in the ROSE Project. Attention was focused mainly on students' responses to sections and items related to environmental issues, regarding their countries' degree of development. The research questions dealt…

  10. A Study of Current Trends and Issues Related to Technical/Engineering Design Graphics.

    Science.gov (United States)

    Clark, Aaron C.; Scales Alice

    2000-01-01

    Presents results from a survey of engineering design graphics educators who responded to questions related to current trends and issues in the profession of graphics education. Concludes that there is a clear trend in institutions towards the teaching of constraint-based modeling and computer-aided manufacturing. (Author/YDS)

  11. Fundamental issues in the manufacturing of nanoelectromechanical (NEMS) and related nanosystems

    International Nuclear Information System (INIS)

    Singh, R.; Alapatt, G.F.; Gupta, N.; Poole, K.F.

    2011-01-01

    Nanostructures in dimension below about 10 nm show interesting properties because of the effect of low-dimension physics. However, to utilize these properties in practice to commercialize NEMS and related nano-systems require an extremely precise manufacturing process. This paper briefly evaluates the fundamental issues involved in manufacturing the nano-scale systems.

  12. 78 FR 9020 - Wireline Competition Bureau Seeks Further Comment on Specific Issues Related to the...

    Science.gov (United States)

    2013-02-07

    ... adjust the Remote Areas Fund usage allowance requirement to reflect consumer behavior, and if so, how... files, audio format), send an email to [email protected] or call the Consumer & Governmental Affairs Bureau... issues relating to the implementation of the Remote Areas Fund as a portable consumer subsidy program, as...

  13. Awareness of legal and social issues related to reproductive health among adolescent girls in rural Varanasi.

    Science.gov (United States)

    Kansal, Sangeeta; Singh, Sweta; Kumar, Alok

    2017-01-01

    Data on awareness of adolescent's on the legal and social issues/acts related to reproductive health, especially in rural areas, are scarce. The aim of the present cross-sectional study is to assess the awareness level of legal and social issues related to reproductive health and its association with the various individual and family/household level characteristics. 650 adolescent girls in the age group of 15-19 years were interviewed with the help of pretested and semistructured questionnaire and focus group discussions were also conducted for qualitative findings in Chiraigaon block of district Varanasi. It was observed that 42.9% of the respondents were aware of legal age of marriage, 14.9% knew about the right age of childbearing. Dowry prohibition act and domestic violence act were known to 46% and 27% respondents, respectively, and only 2.6% were aware of medical termination of pregnancy act. Logistic regression analysis shows the significant effect of education on awareness of legal age of marriage, right age of childbearing, domestic violence, and dowry prohibition acts, which is also supported by qualitative findings. All the important legal issues/acts should be included in high school curriculum and female teachers should be involved in training program for adolescents. Role of mass media in creating awareness about these issues in their routine programs should be ascertained. Accredited Social Health Activist and Anganwadi workers should be aware of and include these issues/acts in adolescent meetings.

  14. Problems in complying with regulations related to low activity materials: Nuclear fuel cycle issues

    International Nuclear Information System (INIS)

    Coates, R.

    1997-01-01

    The range of issues relating to exemption and clearance within the nuclear fuel cycle is reviewed. It is concluded that current regulatory systems and the underpinning technical criteria are potentially inflexible and over-conservative, resulting in an imbalance in the use of society's resources. Proposals are developed for establishing practical requirements which would ensure that resource allocation is commensurate with the magnitude of the risks and in broad proportion to the other risks affecting society. Such an approach would be consistent with the concept of sustainability and could support wider public acceptance of these issues. Within this approach the practical distinction between exemption and clearance is challenged. (author)

  15. Climate and climate-related issues for the safety assessment SR-Can

    International Nuclear Information System (INIS)

    Naeslund, Jens-Ove

    2006-11-01

    The purpose of this report is to document current scientific knowledge of the climate-related conditions and processes relevant to the long-term safety of a KBS-3 repository to a level required for an adequate treatment in the safety assessment SR-Can. The report also includes a concise background description of the climate system. The report includes three main chapters: A description of the climate system (Chapter 2); Identification and discussion of climate-related issues (Chapter 3); and, A description of the evolution of climate-related conditions for the safety assessment (Chapter 4). Chapter 2 includes an overview of present knowledge of the Earth climate system and the climate conditions that can be expected to occur in Sweden on a 100,000 year time perspective. Based on this, climate-related issues relevant for the long-term safety of a KBS-3 repository are identified. These are documented in Chapter 3 'Climate-related issues' to a level required for an adequate treatment in the safety assessment. Finally, in Chapter 4, 'Evolution of climate-related conditions for the safety assessment' an evolution for a 120,000 year period is presented, including discussions of identified climate-related issues of importance for repository safety. The documentation is from a scientific point of view not exhaustive, since such a treatment is neither necessary for the purposes of the safety assessment nor possible within the scope of a safety assessment. As further described in the SR-Can Main Report and in the Features Events and Processes report, the content of the present report has been audited by comparison with FEP databases compiled in other assessment projects. This report follows as far as possible the template for documentation of processes regarded as internal to the repository system. However, the term processes is not used in this report, instead the term issue has been used. Each issue includes a set of processes together resulting in the behaviour of a

  16. Climate and climate-related issues for the safety assessment SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Naeslund, Jens-Ove (comp.)

    2006-11-15

    The purpose of this report is to document current scientific knowledge of the climate-related conditions and processes relevant to the long-term safety of a KBS-3 repository to a level required for an adequate treatment in the safety assessment SR-Can. The report also includes a concise background description of the climate system. The report includes three main chapters: A description of the climate system (Chapter 2); Identification and discussion of climate-related issues (Chapter 3); and, A description of the evolution of climate-related conditions for the safety assessment (Chapter 4). Chapter 2 includes an overview of present knowledge of the Earth climate system and the climate conditions that can be expected to occur in Sweden on a 100,000 year time perspective. Based on this, climate-related issues relevant for the long-term safety of a KBS-3 repository are identified. These are documented in Chapter 3 'Climate-related issues' to a level required for an adequate treatment in the safety assessment. Finally, in Chapter 4, 'Evolution of climate-related conditions for the safety assessment' an evolution for a 120,000 year period is presented, including discussions of identified climate-related issues of importance for repository safety. The documentation is from a scientific point of view not exhaustive, since such a treatment is neither necessary for the purposes of the safety assessment nor possible within the scope of a safety assessment. As further described in the SR-Can Main Report and in the Features Events and Processes report, the content of the present report has been audited by comparison with FEP databases compiled in other assessment projects. This report follows as far as possible the template for documentation of processes regarded as internal to the repository system. However, the term processes is not used in this report, instead the term issue has been used. Each issue includes a set of processes together resulting in the

  17. Inter-organizational future proof EHR systems. A review of the security and privacy related issues.

    Science.gov (United States)

    van der Linden, Helma; Kalra, Dipak; Hasman, Arie; Talmon, Jan

    2009-03-01

    Identification and analysis of privacy and security related issues that occur when health information is exchanged between health care organizations. Based on a generic scenario questions were formulated to reveal the occurring issues. Possible answers were verified in literature. Ensuring secure health information exchange across organizations requires a standardization of security measures that goes beyond organizational boundaries, such as global definitions of professional roles, global standards for patient consent and semantic interoperable audit logs. As to be able to fully address the privacy and security issues in interoperable EHRs and the long-life virtual EHR it is necessary to realize a paradigm shift from storing all incoming information in a local system to retrieving information from external systems whenever that information is deemed necessary for the care of the patient.

  18. Report on the bill project related to the struggle against proliferation of weapons of mass destruction and their delivery systems

    International Nuclear Information System (INIS)

    2010-01-01

    In a first part presenting the various forms of proliferations, the author first gives a quantitative overview of illegal activities concerning nuclear materials, and then discusses the existence and activities of proliferation networks, explaining how international trade liberalization creates a favourable context for proliferations of any kind, and describing how a typical network is organised. He also discusses the example of Iraq and the case of the network created by the Pakistani scientist Abdul Q. Khan. The risk created by the hypothetical relationship between terrorism and nuclear weapon of mass destruction is also questioned. Then, after having recalled the existing international texts and the present national legislation, the author comments the contribution on the bill project and outlines aspects which are not dealt with by this bill project: radiological devices and cybernetic attacks. Then he reports the comments made by the commission on the bill project articles which define interdictions, sanctions and sentences, or procedures against people or organisations involved in the financing or the use of weapons of mass destruction (biological and chemical). A table gives a comparison between the bill project text and the commission's propositions

  19. Islamic Religious Leaders in Israel as Social Agents for Change on Health-Related Issues.

    Science.gov (United States)

    Cohen-Dar, Michal; Obeid, Samira

    2017-12-01

    Islamic religious leaders (IRLs) have the potential to influence health education, health promotion, and positive health outcomes among their own communities. This study aims to examine the role and effectiveness of Arab Muslim religious leaders, in Israel, as social agents for change on health-related issues, focusing on reduction in infant mortality, prematurity, and congenital malformations attributed to consanguineous marriage. A self-administrated questionnaire was distributed to 127 IRLs, in 2012, to gain insights into practice, attitudes, and perceptions of IRLs toward their role as social agents for change on health-related issues. The results indicate that two-thirds (58%) of the surveyed IRLs have provided frequent advice on issues related to preventing infant mortality, congenital malformation, and prematurity over the past two years. Most IRLs indicated that they have keen interest in their communities' health matters (97%) and regard dealing with them as part of their job (85%). The study identified three enabling factors that had significant influence on the IRLs' attitude. These influences are: awareness and knowledge of the health issues, the perception that these issues and their impact on the community are part of their responsibility, and the empowerment they felt through the participation in the Ministry of Health (Northern Region Health Office) educational seminar series, in the year 2000. The main conclusion from this study indicates that IRLs are effective social agents for change and that the educational interventions can be a useful and effective strategy to encourage IRLs to cooperate with health providers and promote public health among their own communities.

  20. Google and Women's Health-Related Issues: What Does the Search Engine Data Reveal?

    Science.gov (United States)

    Baazeem, Mazin; Abenhaim, Haim

    2014-01-01

    Identifying the gaps in public knowledge of women's health related issues has always been difficult. With the increasing number of Internet users in the United States, we sought to use the Internet as a tool to help us identify such gaps and to estimate women's most prevalent health concerns by examining commonly searched health-related keywords in Google search engine. We collected a large pool of possible search keywords from two independent practicing obstetrician/gynecologists and classified them into five main categories (obstetrics, gynecology, infertility, urogynecology/menopause and oncology), and measured the monthly average search volume within the United States for each keyword with all its possible combinations using Google AdWords tool. We found that pregnancy related keywords were less frequently searched in general compared to other categories with an average of 145,400 hits per month for the top twenty keywords. Among the most common pregnancy-related keywords was "pregnancy and sex' while pregnancy-related diseases were uncommonly searched. HPV alone was searched 305,400 times per month. Of the cancers affecting women, breast cancer was the most commonly searched with an average of 247,190 times per month, followed by cervical cancer then ovarian cancer. The commonly searched keywords are often issues that are not discussed in our daily practice as well as in public health messages. The search volume is relatively related to disease prevalence with the exception of ovarian cancer which could signify a public fear.

  1. Leveraging People-Related Maturity Issues for Achieving Higher Maturity and Capability Levels

    Science.gov (United States)

    Buglione, Luigi

    During the past 20 years Maturity Models (MM) become a buzzword in the ICT world. Since the initial Crosby's idea in 1979, plenty of models have been created in the Software & Systems Engineering domains, addressing various perspectives. By analyzing the content of the Process Reference Models (PRM) in many of them, it can be noticed that people-related issues have little weight in the appraisals of the capabilities of organizations while in practice they are considered as significant contributors in traditional process and organizational performance appraisals, as stressed instead in well-known Performance Management models such as MBQA, EFQM and BSC. This paper proposes some ways for leveraging people-related maturity issues merging HR practices from several types of maturity models into the organizational Business Process Model (BPM) in order to achieve higher organizational maturity and capability levels.

  2. Ethical issues related to computerised family medical histories in sickle cell disease: Inforare.

    Science.gov (United States)

    Franrenet, Sandra; Duchange, Nathalie; Galactéros, Fréderic; Quantin, Catherine; Cohen, Olivier; Nzouakou, Ruben; Sudraud, Sophie; Hervé, Christian; Moutel, Grégoire

    2010-10-01

    The Inforare project aims to set up a system for the sharing of clinical and familial data, in order to study how genes are related to the severity of sickle cell disease. While the computerisation of clinical records represents a valuable research goal, an ethical framework is necessary to guarantee patients' protection and their rights in this developing field. Issues relating to patient information during the Inforare study were analysed by the steering committee. Several major concerns were discussed by the committee and formalized in the patients' information letter: educating patients to aid the recruitment of family members, rules of confidentiality and the disclosure of aggregate, individual and unexpected research results. This paper presents the main issues addressed.

  3. Experimental programs and facilities for ASTRID development related to the Severe Accident Issue

    International Nuclear Information System (INIS)

    Journeau, C.; Suteau, C.; Trotignon, L.; Willermoz, G.; Ducros, G.; Courouau, J.L.; Ruggieri, J.M.; Serre, F.

    2013-01-01

    A comprehensive experimental program has been launched in order to gain new data in support of the severe accident studies related to the ASTRID demonstrator. The main new issues with respect to the historic experimental database are mainly related to new design options: heterogeneous core with thick pins; new materials; new severe accident mitigation systems such as - corium discharge channels; - core-catcher with sacrificial materials; - some issues remaining open as Fuel Coolant Interaction. Experiments are needed both in-pile and out of pile: - Depending on the objectives, the out of pile experiments can be conducted - with simulant; - with prototypic corium; - or with irradiated fuel. A new large scale corium facility, FOURNAISE, must be built to fulfill this program. Already, experimental R&D started in existing facilities, such as VITI or CORRONA

  4. An interpretation of schedule 1 of the Radioactive Substances Act 1993 and related issues

    International Nuclear Information System (INIS)

    Hill, M.; Wakerley, M.W.

    2000-09-01

    Schedule 1 of the UK's Radioactive Substances Act 1993 was originally Schedule 3 of the 1960 Act of the same name. It is possible that different methods are currently being employed to interpret how Schedule 1 should be used. This report provides an interpretation and guidance on this and related issues. It is primarily for technical specialists already familiar with the workings of the Act. This report covers the period 1999/2000

  5. Using Agent Based Distillation to Explore Issues Related to Asymmetric Warfare

    Science.gov (United States)

    2009-10-01

    official definition of asymmetric warfare , considering that its use was redundant to irregular warfare [30]. 2 Such as the Lanchester Equations...RTP-MP-MSG-069 23 - 1 Using Agent Based Distillation to Explore Issues Related to Asymmetric Warfare Martin Adelantado, Jean-Michel Mathé...shows that both conventional and asymmetric warfare are characterised by nonlinear behaviours and that engagement is a Complex Adaptive System (CAS

  6. Materials compatibility issues related to thermal energy storage for a space solar dynamic power system

    Science.gov (United States)

    Faget, N. M.

    1986-01-01

    Attention is given to results obtained to date in developmental investigations of a thermal energy storage (TES) system for the projected NASA Space Station's solar dynamic power system; these tests have concentrated on issues related to materials compatibility for phase change materials (PCMs) and their containment vessels' materials. The five PCMs tested have melting temperatures that correspond to the operating temperatures of either the Brayton or Rankine heat engines, which were independently chosen for their high energy densities.

  7. The Asilomar Survey: Stakeholders? Opinions on Ethical Issues Related to Brain-Computer Interfacing

    OpenAIRE

    Nijboer, Femke; Clausen, Jens; Allison, Brendan Z.; Haselager, Pim

    2011-01-01

    Brain-Computer Interface (BCI) research and (future) applications raise important ethical issues that need to be addressed to promote societal acceptance and adequate policies. Here we report on a survey we conducted among 145 BCI researchers at the 4th International BCI conference, which took place in May–June 2010 in Asilomar, California. We assessed respondents’ opinions about a number of topics. First, we investigated preferences for terminology and definitions relating to BCIs. Second, w...

  8. Methodological and theoretical issues in the comparative analysis of gender relations in Western Europe

    OpenAIRE

    S Walby

    1994-01-01

    The aim in this paper is to contribute to the development of a research agenda for the comparative analysis of gender relations in Western Europe. Its focus is the clarification of the methodological and theoretical issues involved. Several different indices of gender inequality are assessed. It is argued that it is important to distinguish between the form and degree of patriarchy, rather than assuming that these are closely associated. Data from the EC and Scandinavia are used to illustrate...

  9. Report on the behalf of the Foreign Affairs, Defense and Armed Forces Commission on the bill project, adopted by the National Assembly, related to the struggle against the proliferation of arms of massive destruction and their vectors

    International Nuclear Information System (INIS)

    2011-01-01

    This report recalls the origins of the bill project which is the implementation of the UN Security Council resolution 1540, the aim of which was to promote the setting up of efficient tools to struggle against proliferation. The bill project aims at updating and reinforcing the existing law arsenal. The report also contains remarks made by the Commission. The bill project addresses several issues: the struggle against proliferation of arms of massive destruction (nuclear weapons, nuclear materials, biological weapons, and chemical weapons), the struggle against proliferation of vectors of arms of massive destruction, double-use goods, the use of these weapons and vectors in acts of terrorism

  10. Nuclear proliferation

    International Nuclear Information System (INIS)

    Stencel, S.

    1978-01-01

    The terms and reactions to President Carter's nuclear policy, culminating in the 1978 Nuclear Non-Proliferation Act, are reviewed and analyzed. The new law increases restrictions on nuclear exports, encourages continued use of light water reactors in preference to plutonium-fueled reactors, and emphasizes technical solutions to proliferation problems. Critics of the law point out that it will hurt U.S. trade unfairly, that other countries do not have as many fuel options as the U.S. has, and that nuclear sales have as many political and economic as technical solutions. Compromise areas include new international safety guidelines, the possibility of an international nuclear fuel bank, and a willingness to consider each case on its merits. 21 references

  11. Decline in Proliferation and Immature Neuron Markers in the Human Subependymal Zone during Aging: Relationship to EGF- and FGF-related Transcripts

    Directory of Open Access Journals (Sweden)

    Christin Weissleder

    2016-11-01

    Full Text Available Neuroblasts exist within the human subependymal zone (SEZ; however, it is debated to what extent neurogenesis changes during normal aging. It is also unknown how precursor proliferation may correlate with the generation of neuronal and glial cells or how expression of growth factors and receptors may change throughout the adult lifespan. We provided evidence of dividing cells in the human SEZ in conjunction with a dramatic age-related decline (n=50; 21-103 years of mRNAs indicative of proliferating cells (Ki67 and immature neurons (doublecortin. Microglia mRNA (ionized calcium-binding adapter molecule 1 increased during aging, whereas transcript levels of stem/precursor cells (glial fibrillary acidic protein delta and achaete-scute homolog 1, astrocytes (vimentin and glial fibrillary acidic protein and oligodendrocytes (oligodendrocyte lineage transcription factor 2 remained stable. Epidermal growth factor receptor (EGFR and fibroblast growth factor 2 (FGF2 mRNAs increased throughout adulthood, while transforming growth factor alpha (TGFα, EGF, Erb-B2 receptor tyrosine kinase 4 (ErbB4 and FGF receptor 1 (FGFR1 mRNAs were unchanged across adulthood. Cell proliferation mRNA positively correlated with FGFR1 transcripts. Immature neuron and oligodendrocyte expression positively correlated with TGFα and ErbB4 mRNAs, whilst astrocyte transcripts positively correlated with EGF, FGF2 and FGFR1 mRNAs. Microglia mRNA positively correlated with EGF and FGF2 expression. Our findings indicate that neurogenesis in the human SEZ continues well into adulthood, although proliferation and neuronal differentiation may decline across adulthood. We suggest that mRNA expression of EGF- and FGF-related family members do not become limited during aging and may modulate neuronal and glial fate determination in the SEZ throughout human life.

  12. Finding online health-related information: usability issues of health portals.

    Science.gov (United States)

    Gurel Koybasi, Nergis A; Cagiltay, Kursat

    2012-01-01

    As Internet and computers become widespread, health portals offering online health-related information become more popular. The most important point for health portals is presenting reliable and valid information. Besides, portal needs to be usable to be able to serve information to users effectively. This study aims to determine usability issues emerging when health-related information is searched on a health portal. User-based usability tests are conducted and eye movement analyses are used in addition to traditional performance measures. Results revealed that users prefer systematic, simple and consistent designs offering interactive tools. Moreover, content and partitions needs to be shaped according to the medical knowledge of target users.

  13. Current issues and related activities in seismic hazard analysis in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Jeong-Moon [Korea Atomic Energy Research Inst., Taejon (Korea, Republic of); Lee, Jong-Rim; Chang, Chun-Joong

    1997-03-01

    This paper discusses some technical issues identified from the seismic hazard analyses for probabilistic safety assessment on the operating Korean nuclear power plants and the related activities to resolve the issues. Since there are no strong instrumental earthquake records in Korea, the seismic hazard analysis is mainly dependent on the historical earthquake records. Results of the past seismic hazard analyses show that there are many uncertainties in attenuation function and intensity level and that there is a need to improve statistical method. The identification of the activity of the Yangsan Fault, which is close to nuclear power plant sites, has been an important issue. But the issue has not been resolved yet in spite of much research works done. Recently, some capable faults were found in the offshore area of Gulupdo Island in the Yellow Sea. It is anticipated that the results of research on both the Yangsan Fault and reduction of uncertainty in seismic hazard analysis will have an significant influence on seismic design and safety assessment of nuclear power plants in the future. (author)

  14. Current issues and related activities in seismic hazard analysis in Korea

    International Nuclear Information System (INIS)

    Seo, Jeong-Moon; Lee, Jong-Rim; Chang, Chun-Joong.

    1997-01-01

    This paper discusses some technical issues identified from the seismic hazard analyses for probabilistic safety assessment on the operating Korean nuclear power plants and the related activities to resolve the issues. Since there are no strong instrumental earthquake records in Korea, the seismic hazard analysis is mainly dependent on the historical earthquake records. Results of the past seismic hazard analyses show that there are many uncertainties in attenuation function and intensity level and that there is a need to improve statistical method. The identification of the activity of the Yangsan Fault, which is close to nuclear power plant sites, has been an important issue. But the issue has not been resolved yet in spite of much research works done. Recently, some capable faults were found in the offshore area of Gulupdo Island in the Yellow Sea. It is anticipated that the results of research on both the Yangsan Fault and reduction of uncertainty in seismic hazard analysis will have an significant influence on seismic design and safety assessment of nuclear power plants in the future. (author)

  15. The international nuclear non-proliferation system

    International Nuclear Information System (INIS)

    Simpson, J.; McGrew, T.

    1985-01-01

    This volume focuses upon the issues raised at this Conference, and attempts to address the international diplomatic, political and trading, rather than technical, questions which surround nuclear non-proliferation policies. It does so by bringing together chapters contributed by participants in non-proliferation diplomacy, those with experience in shaping International Atomic Energy Agency and national policies and academic observers of non-proliferation activities and the international nuclear industry. An analysis is provided of past non-proliferation policies and activities and current issues, and an attempt is made to offer ideas for new initiatives which may sustain the non-proliferation system in the future

  16. Proceedings of the fifth national symposium on environment: focal theme environmental issues related to mining, milling and metallurgy

    International Nuclear Information System (INIS)

    Sastry, V.N.; Bapat, V.N.; Desai, M.V.M.

    1996-02-01

    The fifth National Symposium on Environment was held in Calcutta from February 28 to March 1, 1996. It focused on environmental issues related to mining, milling and metallurgy. Some of the topics covered are coal mining and related environmental issues, chromium mining and associated environmental problems, heavy metals especially nuclear materials and the environmental management strategies, arsenic contamination in water in West Bengal areas and radiological issues related to fertilizers and gypsum industries. Papers relevant to INIS are indexed separately. refs., figs., tabs

  17. Teacher formation related to socio-scientific issues: complexity, contributions and limitations of an educational practice

    Directory of Open Access Journals (Sweden)

    Mariuce Campos de Moraes

    2015-12-01

    Full Text Available This reflection refers to teacher formation related to socio-scientific issues. Whereas such matters take into account the impact of scientific development in society, including ethical aspects and encompass dilemmas involving a wide range of prospects for its resolution, we propose analysis of the complexity that is inherent in their teaching. Thus, we aimed to analyze different spaces and teaching time that produce and are produced in close linkage between theory and practice, as well as their contributions and limitations. The study required a dynamic conversation system that led to the analysis indicators. The issue of sustainability was shown to be feasible for educational planning as cover technical and scientific knowledge, ethical, social and economic pressures. The collective production allowed understand arguments and reflective-creative processes. The lived relations in schools has accompanied and limited the ideas expressed on the socio-scientific issues. We understand that the simultaneity of research and reflection in the sociocultural context has strengthened teacher formation.

  18. Comparative evaluation of three proliferation markers, Ki-67, TOP2A, and RacGAP1, in bronchopulmonary neuroendocrine neoplasms: Issues and prospects

    Science.gov (United States)

    Neubauer, Elisa; Wirtz, Ralph M.; Kaemmerer, Daniel; Athelogou, Maria; Schmidt, Lydia; Sänger, Jörg; Lupp, Amelie

    2016-01-01

    The classification of bronchopulmonary neuroendocrine neoplasms (BP-NEN) into four tumor entities (typical carcinoids (TC), atypical carcinoids (AC), small cell lung cancers (SCLC), large cell neuroendocrine lung carcinomas (LCNEC)) is difficult to perform accurately, but important for prognostic statements and therapeutic management decisions. In this regard, we compared the expression of three proliferation markers, Ki-67, Topoisomerase II alpha (TOP2A), and RacGAP1, in a series of tumor samples from 104 BP-NEN patients (24 TC, 21 AC, 52 SCLC, 7 LCNEC) using different evaluation methods (immunohistochemistry (IHC): Average evaluation, Hotspot evaluation, digital image analysis; RT-qPCR). The results indicated that all three markers had increased protein and mRNA expression with poorer differentiation and correlated well with each other, as well as with grading, staging, and poor survival. Compared with Ki-67 and TOP2A, RacGAP1 allowed for a clearer prognostic statement. The cut-off limits obtained for Ki-67-Average (IHC) were TC-AC 1.5, AC-SCLC 19, and AC-LCNEC 23.5. The Hotspot evaluation generated equal to higher, the digital image analysis generally lower between-entity cut-off limits. All three markers enabled a clear-cut differentiation between the BP-NEN entities, and all methods evaluated were suitable for marker assessment. However, to define optimal cut-off limits, the Ki-67 evaluation methods should be standardized. RacGAP1 appeared to be a new marker with great potential. PMID:27259241

  19. Survey of Indian issues in the state of New Mexico relating to uranium mining and milling

    International Nuclear Information System (INIS)

    Vandevender, S.G.; Barsumian, L.; Gurbaxani, S.H.

    1979-11-01

    Estimates of Indian uranium resources range from 11 to 50% of the US total resources. About 17% of New Mexico's reserves are known to be on Indian lands. New Mexico has produced almost half of the nation's uranium supply; over half of the known reserves are located within the state. However, the state has virtually no jurisdiction over development of Indian uranium. As a result, economic and environmental impacts on the state are beyond its control. The lack of state and federal control over these impacts is influencing how the Indians allow development to proceed. The impacts of Indian uranium development also influence state control of non-Indian. To the extent that these controls affect the availability of uranium concentrate, DOE needs to understand the issues involved. This issue paper identifies some of the related problems for both the Indians and the state and explores the reasons behind them

  20. Unsolved issues related to thermal-hydraulics in the suppression chamber during Fukushima Daiichi accident progressions

    International Nuclear Information System (INIS)

    Mizokami, Shinya; Yamada, Daichi; Honda, Takeshi; Yamauchi, Daisuke; Yamanaka, Yasunori

    2016-01-01

    On 11 March 2011, the Great East Japan Earthquake and Tsunami hit the Fukushima Daiichi Nuclear Power Station. The Fukushima Daiichi Units 1-3 lost all DC and AC power supplies, which set in motion a chain of events that led to releases of radioactivity to the environment. Since then, TEPCO has made many efforts to investigate the accident progressions and the status of the reactors and containment vessels. However, there still exist several tens of unsolved issues to be investigated for the fully understanding of the accident. In this paper, we introduce the unsolved issues related to thermal-hydraulics in the suppression chamber during the Fukushima Daiichi accident progressions. Especially, in Units 2 and 3, there are possibilities that thermal stratification inside their suppression chambers played an important role. It is important that these phenomena are addressed following both theoretical and experimental approaches as support to severe accident simulations. (author)

  1. Current ethical and legal issues in health-related direct-to-consumer genetic testing.

    Science.gov (United States)

    Niemiec, Emilia; Kalokairinou, Louiza; Howard, Heidi Carmen

    2017-09-01

    A variety of health-related genetic testing is currently advertized directly to consumers. This article provides a timely overview of direct-to-consumer genetic testing (DTC GT) and salient ethical issues, as well as an analysis of the impact of the recently adopted regulation on in vitro diagnostic medical devices on DTC GT. DTC GT companies currently employ new testing approaches, report on a wide spectrum of conditions and target new groups of consumers. Such activities raise ethical issues including the questionable analytic and clinical validity of tests, the adequacy of informed consent, potentially misleading advertizing, testing in children, research uses and commercialization of genomic data. The recently adopted regulation on in vitro diagnostic medical devices may limit the offers of predisposition DTC GT in the EU market.

  2. Issues relating to the siting of tritium-fueled fusion experiments

    International Nuclear Information System (INIS)

    Reilly, H.J.; Holland, D.F.

    1985-01-01

    A preconceptual design study and safety analysis of the Tokamak Fusion Core Experiment (TFCX) was conducted in 1984 for the Department of Energy. This paper summarizes the calculations and comparisons related to TFCX siting and environmental issues such as radiological doses to the public living near the facility. Included are discussions of (a) routine and accidental releases of tritium, (b) routine releases of activated air, (c) direct radiation (including ''skyshine''), and (d) seismic criteria. Other potential issues are also discussed including the amount of tritium that might be retained in the graphite armor in the torus, the possible severity of magnet accidents, and the extent of damage due to plasma disruptions. The conclusions drawn from these calculations should be applicable to some of the other planned ignited core experiments that have operating parameters similar to those of TFCX

  3. Issues relating to the siting of tritium-fueled fusion experiments

    International Nuclear Information System (INIS)

    Reilly, H.J.; Holland, D.F.

    1985-01-01

    A preconceptual design study and safety analysis of the Tokamak Fusion Core Experiment (TFCX) was conducted in 1984 for the Department of Energy. This paper summarizes the calculations and comparisons related to TFCX siting and environmental issues such as radiological doses to the public living near the facility. Included are discussions of (a) routine and accidental releases of tritium, (b) routine releases of activated air, (c) direct radiation (including skyshine), and (d) seismic criteria. Other potential issues are also discussed including the amount of tritium that might be retained in the graphite armor in the torus, the possible severity of magnet accidents, and the extent of damage due to plasma disruptions. The conclusions drawn from these calculations should be applicable to some of the other planned ignited core experiments that have operating parameters similar to those of TFCX

  4. Current research issues related to post-wildfire runoff and erosion processes

    Science.gov (United States)

    Moody, John A.; Shakesby, Richard A.; Robichaud, Peter R.; Cannon, Susan H.; Martin, Deborah A.

    2013-01-01

    Research into post-wildfire effects began in the United States more than 70 years ago and only later extended to other parts of the world. Post-wildfire responses are typically transient, episodic, variable in space and time, dependent on thresholds, and involve multiple processes measured by different methods. These characteristics tend to hinder research progress, but the large empirical knowledge base amassed in different regions of the world suggests that it should now be possible to synthesize the data and make a substantial improvement in the understanding of post-wildfire runoff and erosion response. Thus, it is important to identify and prioritize the research issues related to post-wildfire runoff and erosion. Priority research issues are the need to: (1) organize and synthesize similarities and differences in post-wildfire responses between different fire-prone regions of the world in order to determine common patterns and generalities that can explain cause and effect relations; (2) identify and quantify functional relations between metrics of fire effects and soil hydraulic properties that will better represent the dynamic and transient conditions after a wildfire; (3) determine the interaction between burned landscapes and temporally and spatially variable meso-scale precipitation, which is often the primary driver of post-wildfire runoff and erosion responses; (4) determine functional relations between precipitation, basin morphology, runoff connectivity, contributing area, surface roughness, depression storage, and soil characteristics required to predict the timing, magnitudes, and duration of floods and debris flows from ungaged burned basins; and (5) develop standard measurement methods that will ensure the collection of uniform and comparable runoff and erosion data. Resolution of these issues will help to improve conceptual and computer models of post-wildfire runoff and erosion processes.

  5. Knockdown of NF-E2-related factor 2 inhibits the proliferation and growth of U251MG human glioma cells in a mouse xenograft model.

    Science.gov (United States)

    Ji, Xiang-Jun; Chen, Sui-Hua; Zhu, Lin; Pan, Hao; Zhou, Yuan; Li, Wei; You, Wan-Chun; Gao, Chao-Chao; Zhu, Jian-Hong; Jiang, Kuan; Wang, Han-Dong

    2013-07-01

    NF-E2-related factor 2 (Nrf2) is a pivotal transcription factor of cellular responses to oxidative stress and recent evidence suggests that Nrf2 plays an important role in cancer pathobiology. However, the underlying mechanism has yet to be elucidated, particularly in glioma. In the present study, we investigated the role of Nrf2 in the clinical prognosis, cell proliferation and tumor growth of human glioblastoma multiforme (GBM). We detected overexpression of Nrf2 protein levels in GBM compared to normal brain tissues. Notably, higher protein levels of Nrf2 were significantly associated with poorer overall survival and 1-year survival for GBM patients. Furthermore, we constructed the plasmid Si-Nrf2 and transduced it into U251MG cells to downregulate the expression of Nrf2 and established stable Nrf2 knockdown cells. The downregulation of Nrf2 suppressed cell proliferation in vitro and tumor growth in mouse xenograft models. We performed immunohistochemistry staining to detect the protein levels of Nrf2, Ki-67, caspase-3 and CD31 in the xenograft tumors and found that the expression levels of Nrf2 and Ki-67 were much lower in the Si-Nrf2 group compared to the Si-control group. In addition, the number of caspase-3-positive cells was significantly increased in the Si-Nrf2 group. By analysis of microvessel density (MVD) assessed by CD31, the MVD value in the Si-Nrf2 group decreased significantly compared to the Si-control group. These findings indicate that the knockdown of Nrf2 may suppress tumor growth by inhibiting cell proliferation, increasing cell apoptosis and inhibiting angiogenesis. These results highlight the potential of Nrf2 as a candidate molecular target to control GBM cell proliferation and tumor growth.

  6. Hospital Malnutrition Related to Fasting and Underfeeding: Is It an Ethical Issue?

    Science.gov (United States)

    Arenas Moya, Diego; Plascencia Gaitán, Alejandra; Ornelas Camacho, Denisse; Arenas Márquez, Humberto

    2016-06-01

    Hospital malnutrition is a relevant clinical issue present in about 50% of patients that is associated with increased morbidity, mortality, and cost of care. Because of the relation of malnutrition with chronic and acute inflammatory processes secondary to disease, nutrition therapy is considered an important medical treatment. However, there is little discussion about the impact of another critical issue related to hospital malnutrition, that is, lack of appropriate food or nutrition therapy given to the patients. Unnecessary fasting practices and the use of inappropriate nutrition prescriptions result in underfeeding that can be a related or direct cause of hospital malnutrition, independent of disease or inflammatory state. Suboptimal prescription of oral, enteral, and parenteral nutrition should be analyzed and discussed from an ethical perspective since this practice has the potential to harm patients. In addition, absence or inadequate provision of nutrition may present barriers for improved patient outcomes and could be prevented by simply recognizing lack of knowledge, skills, or experience in nutrition and entrusting nutrition prescription to interdisciplinary teams with clinicians well prepared in nutrition sciences. This article reviews potential barriers to the prevention or treatment of hospital malnutrition and proposes specific actions that can help clinicians to overcome and implement optimal nutrition not just as medical therapy but also as a basic comfort care that may help patients nutritionally, clinically, physically, and emotionally. © 2016 American Society for Parenteral and Enteral Nutrition.

  7. Current issues relating to psychosocial job strain and cardiovascular disease research.

    Science.gov (United States)

    Theorell, T; Karasek, R A

    1996-01-01

    The authors comment on recent reviews of cardiovascular job strain research by P. L. Schnall and P. A. Landsbergis (1994), and by T. S. Kristensen (1995), which conclude that job strain as defined by the demand-control model (the combination of contributions of low job decision latitudes and high psychological job demands) is confirmed as a risk factor for cardiovascular mortality in a large majority of studies. Lack of social support at work appears to further increase risk. Several still-unresolved research questions are examined in light of recent studies: (a) methodological issues related to use of occupational aggregate estimations and occupational career aggregate assessments, use of standard scales for job analysis and recall bias issues in self-reporting; (b) confounding factors and differential strengths of association by subgroups in job strain-cardiovascular disease analyses with respect to social class, gender, and working hours; and (c) review of results of monitoring job strain-blood pressure associations and associated methodological issues.

  8. Environmental, health and safety issues related to commercializing CuInSe{sub 2}-based photovoltaics

    Energy Technology Data Exchange (ETDEWEB)

    Eberspacher, C. [UNISUN, Newbury Park, CA (United States); Fthenakis, V.M.; Moskowtiz, P.D. [Brookhaven National Lab., Upton, NY (United States)

    1996-07-01

    Photovoltaics technology is rapidly evolving towards a new generation of low-cost thin film technologies. One of the most promising materials in this new generation is copper indium selenide (CuInSe{sub 2} or CIS). As with any new material, successful commercialization of CIS photovoltaic (PV) technology will require attention to environmental, health and safety issues, including consideration of the sources, usage, and end-of-product-life disposal and/or recycling of the constituent materials. This work focuses on three specific environmental, health and safety (EH and S) issues related to CIS PV: (1) economics are analyzed to determine their impact on materials use and re-use; (2) Federal and California State environmental disposal and waste handling regulations are analyzed to evaluate their impact on PV module manufacturing and end-of-life module handling; and (3) the logistics and economics of product recycling and waste disposal by industries with comparable EH and S issues are examined to quantify the corresponding options available for handling, disposing of and/or recycling manufacturing by-products and end-of-life modules.

  9. Impact of direct-to-consumer advertising (DTCA) on patient health-related behaviors and issues.

    Science.gov (United States)

    Polen, Hyla H; Khanfar, Nile M; Clauson, Kevin A

    2009-01-01

    The pharmaceutical industry spends billions of dollars annually on direct-to-consumer advertising (DTCA). Patient perspectives on the impact of televised DTCA on health-related behaviors and issues were assessed by means of a 68-question survey. 58.6% of respondents believed that DTCA allowed consumers to have a more active role in managing their health. However, 27.6% felt DTCA caused confusion, and an alarming 17.8% of respondents stopped taking their medication because of concerns about serious side effects mentioned in DTCA. Overall, participants believed DTCA plays a useful role in health self-management; however, a considerable percentage thought that the cost outweighs the benefits.

  10. User requirements for innovative nuclear reactors and fuel cycle technologies in the area of economics, environment, safety, waste management, proliferation resistance and cross cutting issues, and methodology for innovative technologies assessment

    International Nuclear Information System (INIS)

    Kupitz, Juergen; Depisch, Frank; Allan, Colin

    2003-01-01

    The IAEA General Conference in 2000 has invited ''all interested Member States to combine their efforts under the aegis of the Agency in considering the issues of the nuclear fuel cycle, in particular by examining innovative and proliferation-resistant nuclear technology''. In response to this invitation, the IAEA initiated an ''International Project on Innovative Nuclear Reactors and Fuel Cycles'', INPRO. The overall objectives of INPRO is to help to ensure that nuclear energy is available to contribute in fulfilling in a sustainable manner energy needs in the 21st century, and to bring together all interested Member States, both technology holders and technology users, to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles that use sound and economically competitive technology. Phase-I of INPRO was initiated in May 2001. During Phase-I, work was subdivided in two sub phase: Phase 1A (finished in June 2003) and Phase 1B (started in June 2003). Phase 1A dealt with the definition of Basic Principles, User Requirements and Criteria, and the development of a methodology for the evaluation of innovative nuclear technologies. In Phase 1A, task groups for several areas were established: (a) Prospects and Potentials of Nuclear Power, (b) Economics; (c) Sustainability and Environment, (d) Safety of Nuclear Installations, (e) Waste Management, (f) Proliferation Resistance, (g) Crosscutting issues and (h) for the Methodology for Assessment. In Phase-IB evaluations of innovative nuclear energy technologies will be performed by Member States against the INPRO Basic Principles, User Requirements and Criteria. This paper summarizes the results achieved in the Phase 1A of INPRO and is a cooperative effort of the INPRO team, consisting of all INPRO cost free experts and task managers. (author)

  11. 17 CFR 230.488 - Effective date of registration statements relating to securities to be issued in certain business...

    Science.gov (United States)

    2010-04-01

    ... statements relating to securities to be issued in certain business combination transactions. 230.488 Section... REGULATIONS, SECURITIES ACT OF 1933 Investment Companies; Business Development Companies § 230.488 Effective date of registration statements relating to securities to be issued in certain business combination...

  12. Developing a research agenda on ethical issues related to using social media in healthcare.

    Science.gov (United States)

    Adams, Samantha A; Van Veghel, Dennis; Dekker, Lukas

    2015-07-01

    The consequences of using publicly available social media applications specifically for healthcare purposes are largely unaddressed in current research. Where they are addressed, the focus is primarily on issues of privacy and data protection. We therefore use a case study of the first live Twitter heart operation in the Netherlands, in combination with recent literature on social media from other academic fields, to identify a wide range of ethical issues related to using social media for health-related purposes. Although this case reflects an innovative approach to public education and patient centeredness, it also illustrates the need for institutions to weigh the various aspects of use and to develop a plan to deal with these on a per case basis. Given the continual development of technologies, researchers may not yet be able to oversee and anticipate all of the potential implications. Further development of a research agenda on this topic, the promotion of guidelines and policies, and the publication of case studies that reveal the granularity of individual situations will therefore help raise awareness and assist physicians and institutions in using social media to support existing care services.

  13. Power system technical performance issues related to the application of long HVAC cables

    DEFF Research Database (Denmark)

    Wiechowski, on behalf of Cigre WG C4.502, W.; Sluis, L. V. der; Ohno, Teruo

    2011-01-01

    This paper reports the progress of work of Cigre Working Group C4.502 “Power system technical performance issues related to the application of long HVAC cables”. The primary goal of the WG C4.502 is to write a technical brochure that will serve as practical guide for performing studies necessary...... for assessing the technical performance of HV/EHV systems with large share of AC cable lines. This paper besides providing a background for formulation of WG C4.502 and its overall aim, describes the tasks that were accomplished before the interim report was submitted to Study Committee C4 System Technical...... Performance in August 2010. The work in the WG is ongoing and final report will be ready according to the time schedule in 2012. The focus of this paper is in particular to show all issues related to system technical performance with assigned weights in terms of their importance and/or uniqueness for cable...

  14. Key Health Information Technologies and Related Issues for Iran: A Qualitative Study.

    Science.gov (United States)

    Hemmat, Morteza; Ayatollahi, Haleh; Maleki, Mohammadreza; Saghafi, Fatemeh

    2018-01-01

    Planning for the future of Health Information Technology (HIT) requires applying a systematic approach when conducting foresight studies. The aim of this study was to identify key health information technologies and related issues for Iran until 2025. This was a qualitative study and the participants included experts and policy makers in the field of health information technology. In-depth semi-structured interviews were conducted and data were analyzed by using framework analysis and MAXQDA software. The findings revealed that the development of national health information network, electronic health records, patient health records, a cloud-based service center, interoperability standards, patient monitoring technologies, telehealth, mhealth, clinical decision support systems, health information technology and mhealth infrastructure were found to be the key technologies for the future. These technologies could influence the economic, organizational and individual levels. To achieve them, the economic and organizational obstacles need to be overcome. In this study, a number of key technologies and related issues were identified. This approach can help to focus on the most important technologies in the future and to priorities these technologies for better resource allocation and policy making.

  15. The Issues of Human Rights in the India-U.S. Relations

    Directory of Open Access Journals (Sweden)

    Zakharov Aleksey I.

    2016-10-01

    Full Text Available The article presents a brief overview of India-U.S. relations during the period of Narendra Modi’s government and Barack Obama’s administration. The author analyzes the dynamics of cooperation development after the victory of Bharatiya Janata Party in the 2014 Parliamentary elections in India and studies the key directions of bilateral agenda. The current condition of India-U.S. strategic dialogue and the influence of human rights issues on the countries’ cooperation are characterized. Since 2014 the states’ cooperation has been growing rapidly. The bilateral investment, trade and economic interdependence have significantly increased. Some experts and mass media note that Barack Obama and Narendra Modi are having friendly relations. From a different angle, a number of agreements between countries still remain unaccomplished. For instance, the U.S. support for India’s permanent seat in the United Nations Security Council, its accession to APEC and the implementation of nuclear deal have yet to be turned into achievement. Together with strengthening the bilateral strategic dialogue, the U.S. has intensified the criticism of India’s human rights record. The main part of it includes the cases of religious intolerance, which are observed in the United States Commission on International Religious Freedom reports and the remarks given by U.S. lawmakers and official representatives, including the Ambassador to India. Washington’s careful attention to the human rights issues and religious violence in particular is one of the major irritants in the U.S.-India relations. The engagement of Indian Americans in the local U.S. politics and their lobbying efforts in the context of U.S.-India relations are revealed. The author outlines the near-terms perspectives of bilateral cooperation.

  16. Some of the issues of modern Russian historiography towards Kazakh-Dzhungarian relations

    Directory of Open Access Journals (Sweden)

    Turganzhan Tulebaev

    2016-03-01

    Full Text Available The relationship between Kazakh people and the Dzhungar Khanate in the 17th - the first half of the 18th centuries was an important milestone in the development of Kazakh sovereignty. Kazakh Khanate had its own place in the development of international relations of the Central Asian countries. The historiography of this problem is very wide. For many years many researchers of post-Soviet, Western, Central Asian countries dedicated their work to this issue. Russian historiography is notable among others for its features. The article discusses some concepts of the modern Russian scientists regarding Kazakh-Dzhungarian relations. Russian historiography of Kazakh-Dzhungarian relations started to develop from the pre-revolutionary period and continues to these days. Kazakhstan scientists of the Soviet period also contributed to the study of international relations in Central Asia in the 17th-18th centuries in line with the required methodological and ideological direction. However, at present in connection with the sovereignization and becoming independent states of the post-Soviet countries, there is some differentiation in the areas of Russian and Kazakh social sciences and humanities. Today our society intentionally seeks to rethink the key milestones of the passed way, know itself and define its new place in the contemporary reality. Therefore, the Russian research on the history of international relations is especially relevant to the public

  17. Identification of unresolved safety issues relating to nuclear power plants. Report to Congress

    International Nuclear Information System (INIS)

    1979-01-01

    The report describes the review undertaken over the last year that resulted in identifying 17 issues as Unresolved Safety Issues. In addition, the report provides specific discussions of why certain issues were not included. The report also provides a brief background discussion describing Section 210 of the Energy Reorganization Act and the NRC program for the resolution of generic issues described in NUREG-0410

  18. A qualitative study exploring issues related to medication management in residential aged care facilities

    Directory of Open Access Journals (Sweden)

    Ahmad Nizaruddin M

    2017-11-01

    Full Text Available Mariani Ahmad Nizaruddin, Marhanis-Salihah Omar, Adliah Mhd-Ali, Mohd Makmor-Bakry Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Background: Globally, the population of older people is on the rise. As families are burdened with the high cost of care for aging members, demand is increasing for medical care and nursing homes. Thus, medication management is crucial to ensure that residents in a care center benefit and assist the management of the care center in reducing the burden of health care. This study is aimed to qualitatively explore issues related to medication management in residential aged care facilities (RACFs.Participants and methods: A total of 11 stakeholders comprising health care providers, administrators, caretakers and residents were recruited from a list of registered government, nongovernmental organization and private RACFs in Malaysia from September 2016 to April 2017. An exploratory qualitative study adhering to Consolidated Criteria for Reporting Qualitative Studies was conducted. In-depth interview was conducted with consent of all participants, and the interviews were audio recorded for later verbatim transcription. Observational analysis was also conducted in a noninterfering manner.Results and discussion: Three themes, namely medication use process, personnel handling medications and culture, emerged in this study. Medication use process highlighted an unclaimed liability for residents’ medication by the RACFs, whereas personnel handling medications were found to lack sufficient training in medication management. Culture of the organization did affect the medication safety and quality improvement. The empowerment of the residents in their medication management was limited. There were unclear roles and responsibility of who manages the medication in the nongovernment-funded RACFs, although they were well structured in the private nursing homes.Conclusion: There are important issues

  19. Health-equity issues related to childhood obesity: a scoping review.

    Science.gov (United States)

    Vargas, Clemencia M; Stines, Elsie M; Granado, Herta S

    2017-06-01

    The purpose of this scoping review was to determine the health-equity issues that relate to childhood obesity. Health-equity issues related to childhood obesity were identified by analyzing food environment, natural and built environment, and social environment. The authors searched Medline, PubMed, and Web of Science, using the keywords "children" and "obesity." Specific terms for each environment were added: "food desert," "advertising," "insecurity," "price," "processing," "trade," and "school" for food environment; "urban design," "land use," "transportation mode," "public facilities," and "market access" for natural and built environment; and "financial capacity/poverty," "living conditions," "transport access," "remoteness," "social support," "social cohesion," "working practices," "eating habits," "time," and "social norms" for social environment. Inclusion criteria were studies or reports with populations under age 12, conducted in the United States, and published in English in 2005 or later. The final search yielded 39 references (16 for food environment, 11 for built environment, and 12 for social environment). Most food-environment elements were associated with obesity, except food insecurity and food deserts. A natural and built environment that hinders access to physical activity resources and access to healthy foods increased the risk of childhood obesity. Similarly, a negative social environment was associated with childhood obesity. More research is needed on the effects of food production, living conditions, time for shopping, and exercise, as related to childhood obesity. Most elements of food, natural and built, and social-environments were associated with weight in children under age 12, except food insecurity and food deserts. © 2017 American Association of Public Health Dentistry.

  20. Use of a web site to increase knowledge and awareness of hunger-related issues.

    Science.gov (United States)

    Jennings, Sharla; Cotugna, Nancy; Vickery, Connie E

    2003-11-01

    The purpose of this study was to determine the current level of knowledge and awareness of hunger-related issues among a convenience sample of Delawareans. We also assessed whether raising knowledge and awareness of the hunger problem through the FBD's newly designed web site would encourage participation in antihunger activities. Via e-mail, 1,719 individuals were invited to participate in a three-phase, online survey, and 392 agreed. Phase-I questions were answered prior to viewing the web site, phase II (n=217) immediately afterward, and phase III (n=61) six weeks later. Responses indicated a high level of awareness about general hunger issues but specific knowledge proved to be at a lower level. No statistically significant differences were noted when data were collapsed across gender, age, educational level, or work setting. In a six-week post-survey, 41% of subjects were motivated by the web site to engage in an antihunger activity; 34% had told others about the web site and indicated it may be a useful tool in antihunger outreach efforts for the FBD.

  1. Common Issues Seen in Paediatric Diabetes Clinics, Psychological Formulations, and Related Approaches to Management

    Directory of Open Access Journals (Sweden)

    Asma Deeb

    2018-01-01

    Full Text Available Diabetes is a chronic disease and its management is associated with multiple challenges. This is particularly the case in children and adolescents. Factors that contribute to difficulties in managing diabetes in youth include psychological characteristics, family dynamics, and social behavior. The purpose of this article is to highlight some psychological issues in children and adolescents with diabetes. We aim to present selected case scenarios encountered by health professionals and to provide tips on strategies for managing psychological aspect of diabetes. We tackle the psychological issues related to diabetes under four main categories: maladaptive disorders, eating disorders, family psychopathology, and family dysfunction. Psychotherapy and psychoanalysis are useful modalities in diabetes management. The psychological intervention is aimed at supporting patients and families to reach a balance between a normal family routine and a good glycemic control. We demonstrate unique requirements in coordinating care for children and adolescents with diabetes and highlight the importance of encouraging a positive behavior. Managing diabetes in children and adolescents needs to be in the form of a collaborative work between health care professionals, children and adolescents, and their families. Caring, supportive family backed up by experienced multidisciplinary team is the best approach to prevent psychological difficulties.

  2. Common Issues Seen in Paediatric Diabetes Clinics, Psychological Formulations, and Related Approaches to Management.

    Science.gov (United States)

    Deeb, Asma; Akle, Mariette; Al Ozairi, Abdulla; Cameron, Fergus

    2018-01-01

    Diabetes is a chronic disease and its management is associated with multiple challenges. This is particularly the case in children and adolescents. Factors that contribute to difficulties in managing diabetes in youth include psychological characteristics, family dynamics, and social behavior. The purpose of this article is to highlight some psychological issues in children and adolescents with diabetes. We aim to present selected case scenarios encountered by health professionals and to provide tips on strategies for managing psychological aspect of diabetes. We tackle the psychological issues related to diabetes under four main categories: maladaptive disorders, eating disorders, family psychopathology, and family dysfunction. Psychotherapy and psychoanalysis are useful modalities in diabetes management. The psychological intervention is aimed at supporting patients and families to reach a balance between a normal family routine and a good glycemic control. We demonstrate unique requirements in coordinating care for children and adolescents with diabetes and highlight the importance of encouraging a positive behavior. Managing diabetes in children and adolescents needs to be in the form of a collaborative work between health care professionals, children and adolescents, and their families. Caring, supportive family backed up by experienced multidisciplinary team is the best approach to prevent psychological difficulties.

  3. Use of a web site to increase knowledge and awareness of hunger-related issues.

    Science.gov (United States)

    Jennings, Sharla; Cotugna, Nancy; Vickery, Connie E.

    2003-01-01

    The purpose of this study was to determine the current level of knowledge and awareness of hunger-related issues among a convenience sample of Delawareans. We also assessed whether raising knowledge and awareness of the hunger problem through the FBD's newly designed web site would encourage participation in antihunger activities. Via e-mail, 1,719 individuals were invited to participate in a three-phase, online survey, and 392 agreed. Phase-I questions were answered prior to viewing the web site, phase II (n=217) immediately afterward, and phase III (n=61) six weeks later. Responses indicated a high level of awareness about general hunger issues but specific knowledge proved to be at a lower level. No statistically significant differences were noted when data were collapsed across gender, age, educational level, or work setting. In a six-week post-survey, 41% of subjects were motivated by the web site to engage in an antihunger activity; 34% had told others about the web site and indicated it may be a useful tool in antihunger outreach efforts for the FBD. PMID:14651376

  4. Materials-related issues in the safety and licensing of nuclear fusion facilities

    Science.gov (United States)

    Taylor, N.; Merrill, B.; Cadwallader, L.; Di Pace, L.; El-Guebaly, L.; Humrickhouse, P.; Panayotov, D.; Pinna, T.; Porfiri, M.-T.; Reyes, S.; Shimada, M.; Willms, S.

    2017-09-01

    Fusion power holds the promise of electricity production with a high degree of safety and low environmental impact. Favourable characteristics of fusion as an energy source provide the potential for this very good safety and environmental performance. But to fully realize the potential, attention must be paid in the design of a demonstration fusion power plant (DEMO) or a commercial power plant to minimize the radiological hazards. These hazards arise principally from the inventory of tritium and from materials that become activated by neutrons from the plasma. The confinement of these radioactive substances, and prevention of radiation exposure, are the primary goals of the safety approach for fusion, in order to minimize the potential for harm to personnel, the public, and the environment. The safety functions that are implemented in the design to achieve these goals are dependent on the performance of a range of materials. Degradation of the properties of materials can lead to challenges to key safety functions such as confinement. In this paper the principal types of material that have some role in safety are recalled. These either represent a potential source of hazard or contribute to the amelioration of hazards; in each case the related issues are reviewed. The resolution of these issues lead, in some instances, to requirements on materials specifications or to limits on their performance.

  5. Methods uncovering usability issues in medication-related alerting functions: results from a systematic review.

    Science.gov (United States)

    Marcilly, Romaric; Vasseur, Francis; Ammenwerth, Elske; Beuscart-Zephir, Marie-Catherine

    2014-01-01

    This paper aims at listing the methods used to evaluate the usability of medication-related alerting functions and at knowing what type of usability issues those methods allow to detect. A sub-analysis of data from this systematic review has been performed. Methods applied in the included papers were collected. Then, included papers were sorted in four types of evaluation: "expert evaluation", "user- testing/simulation", "on site observation" and "impact studies". The types of usability issues (usability flaws, usage problems and negative outcomes) uncovered by those evaluations were analyzed. Results show that a large set of methods are used. The largest proportion of papers uses "on site observation" evaluation. This is the only evaluation type for which every kind of usability flaws, usage problems and outcomes are detected. It is somehow surprising that, in a usability systematic review, most of the papers included use a method that is not often presented as a usability method. Results are discussed about the opportunity to provide usability information collected after the implementation of the technology during their design process, i.e. before their implementation.

  6. Waste management regulatory compliance issues related to D ampersand D activities at Oak Ridge National Laboratory (ORNL)

    International Nuclear Information System (INIS)

    Hitch, J.P.; Arnold, S.E.; Burwinkle, T.; Daugherty, D.

    1994-01-01

    The waste management activities at ORNL related to the decontamination and decommissioning (D ampersand D) of radioactively contaminated buildings are divided into four categories: Operational facilities, inactive or surplus facilities, future facilities planning, and D ampersand D activities. This paper only discusses regulatory issues related to inactive or surplus facilities. Additionally, rather than attempting to address all resulting waste streams and related regulations, this paper highlights only a few of the ORNL waste streams that present key regulatory issues

  7. How to govern physician-hospital exchanges: contractual and relational issues in Belgian hospitals.

    Science.gov (United States)

    Trybou, Jeroen; Gemmel, Paul; Annemans, Lieven

    2014-07-01

    Our aim was to investigate contractual mechanisms in physician-hospital exchanges. The concepts of risk-sharing and the nature of physician-hospital exchanges - transactional versus relational - were studied. Two qualitative case studies were performed in Belgium. Hospital executives and physicians were interviewed to develop an in-depth understanding of contractual and relational issues that shape physician-hospital contracting in acute care hospitals. The underlying theoretical concepts of agency theory and social exchange theory were used to analyse the data. Our study found that physician-hospital contracting is highly complex. The contract is far more than an economic instrument governing financial aspects. The effect of the contract on the nature of exchange - whether transactional or relational - also needs to be considered. While it can be argued that contractual governance methods are increasingly necessary to overcome the difficulties that arise from the fragmented payment framework by aligning incentives and sharing financial risk, they undermine the necessary relational governance. Relational qualities such as mutual trust and an integrative view on physician-hospital exchanges are threatened, and may be difficult to sustain, given the current fragmentary payment framework. Since health care policy makers are increasing the financial risk borne by health care providers, it can be argued that this also increases the need to share financial risk and to align incentives between physician and hospital. However, our study demonstrates that while economic alignment is important in determining physician-hospital contracts, the corresponding impact on working relationships should also be considered. Moreover, it is important to avoid a relationship between hospital and physician predominantly characterized by transactional exchanges thereby fostering an unhealthy us-and-them divide and mentality. Relational exchange is a valuable alternative to contractual

  8. Several issues related to regional environmental investigation to inland nuclear power plant

    International Nuclear Information System (INIS)

    Tian Xinshan; Zhang Xiaofeng

    2010-01-01

    Based on the goal of carrying out regional environmental investigation and review of recent environmental investigations toward inland nuclear power plant(NPP) site, and combined with the characteristics between inland and coastal sites, this paper is to make deeply analysis on population distribution, environmental characteristics, feasibility of performing emergency plan, characteristics of received water and external human-induced incident of NPP vicinity, then advance several significant issues related regional environmental investigation to inland sites, and make comparison with the investigation to coastal sites. Meantime, on guarantee of the integrity of collected materials during investigation, this paper also makes several proposals to provide reference for carrying out regional environmental investigation to inland NPP site. (authors)

  9. Hinkley Point 'C' power station public inquiry: proof of evidence on local site related issues

    International Nuclear Information System (INIS)

    Gammon, K.M.

    1988-09-01

    A public inquiry has been set up to examine the planning application made by the Central Electricity Generating Board (CEGB) for the construction of a 1200 MW Pressurized Water Reactor power station at Hinkley Point (Hinkley Point ''C'') in the United Kingdom, adjacent to an existing nuclear power station. The CEGB evidence to the Inquiry on local site related issues begins by setting the proposed development within the context of local authority planning policies for the area. The implications of the development in terms of overall land needs, construction, access, buildings and works both temporary and permanent, are described. Environmental impacts, aesthetic and socio-economic factors are considered including possible effects on agriculture, nature conservation, water supply, transport and employment. (UK)

  10. Senior Seminar Focusing on Societal Issues Related to Chemistry and Biochemistry

    Science.gov (United States)

    White, Harold B., III; Johnston, Murray V.; Panar, Manuel

    2000-12-01

    The lack of a clearly defined content or structure provided the opportunity to transform a one-credit, pass-fail senior seminar course into a meaningful capstone experience for chemistry and biochemistry majors. In addition to individual and class exercises associated with employment, graduate school, communication skills, and professional ethics, small groups of students worked together to create informative Web sites that took positions on important societal issues related to chemistry. Each group presented a seminar and responded to questions from their peers and two or more unannounced visitors, "wild cards" who often had expertise in the seminar topic. Throughout the course, the instructors placed particular emphasis on developing students' ability to work cooperatively, locate and evaluate information, make informed judgments based on available information, and logically develop and defend their positions. Input from a retired industrial chemist helped define these skill elements.

  11. Surface Modeling, Grid Generation, and Related Issues in Computational Fluid Dynamic (CFD) Solutions

    Science.gov (United States)

    Choo, Yung K. (Compiler)

    1995-01-01

    The NASA Steering Committee for Surface Modeling and Grid Generation (SMAGG) sponsored a workshop on surface modeling, grid generation, and related issues in Computational Fluid Dynamics (CFD) solutions at Lewis Research Center, Cleveland, Ohio, May 9-11, 1995. The workshop provided a forum to identify industry needs, strengths, and weaknesses of the five grid technologies (patched structured, overset structured, Cartesian, unstructured, and hybrid), and to exchange thoughts about where each technology will be in 2 to 5 years. The workshop also provided opportunities for engineers and scientists to present new methods, approaches, and applications in SMAGG for CFD. This Conference Publication (CP) consists of papers on industry overview, NASA overview, five grid technologies, new methods/ approaches/applications, and software systems.

  12. Ice issues relating to the Kashagan phase II development, North Caspian Sea.

    Energy Technology Data Exchange (ETDEWEB)

    Croasdale, Ken [KRCA, Calgary (Canada); Verlaan, Paul [Shell Development Kashagan, London (United Kingdom)

    2011-07-01

    The ice conditions in the north Caspian Sea are challenging for the Kashagan field development. The climatic conditions of the area are extreme, with cold winters (-30 degrees C) and hot summers (+40 degrees C). The presence and the quantity of ice are also highly variable from year to year. This paper investigated the major ice-related issues affecting the Kashagan structures and pipelines. An extensive description of the ice environment was provided. Ice design criteria for the offshore rock islands, the pipelines and the layout of the ice protection barriers around the islands were presented. It was found that the ice design methods used in Arctic areas have required some adaptations to meet Caspian conditions. All the islands were designed with an ice encroachment zone to reduce the hazardous effect of the ice rubble encroaching. Rock sloped barriers and steel barriers were implanted around the islands to protect the logistical areas.

  13. A qualitative study exploring issues related to medication management in residential aged care facilities.

    Science.gov (United States)

    Ahmad Nizaruddin, Mariani; Omar, Marhanis-Salihah; Mhd-Ali, Adliah; Makmor-Bakry, Mohd

    2017-01-01

    Globally, the population of older people is on the rise. As families are burdened with the high cost of care for aging members, demand is increasing for medical care and nursing homes. Thus, medication management is crucial to ensure that residents in a care center benefit and assist the management of the care center in reducing the burden of health care. This study is aimed to qualitatively explore issues related to medication management in residential aged care facilities (RACFs). A total of 11 stakeholders comprising health care providers, administrators, caretakers and residents were recruited from a list of registered government, nongovernmental organization and private RACFs in Malaysia from September 2016 to April 2017. An exploratory qualitative study adhering to Consolidated Criteria for Reporting Qualitative Studies was conducted. In-depth interview was conducted with consent of all participants, and the interviews were audio recorded for later verbatim transcription. Observational analysis was also conducted in a noninterfering manner. Three themes, namely medication use process, personnel handling medications and culture, emerged in this study. Medication use process highlighted an unclaimed liability for residents' medication by the RACFs, whereas personnel handling medications were found to lack sufficient training in medication management. Culture of the organization did affect the medication safety and quality improvement. The empowerment of the residents in their medication management was limited. There were unclear roles and responsibility of who manages the medication in the nongovernment-funded RACFs, although they were well structured in the private nursing homes. There are important issues related to medication management in RACFs which require a need to establish policy and guidelines.

  14. Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy

    Science.gov (United States)

    Brooks-Kayal, Amy R.; Bath, Kevin G.; Berg, Anne T.; Galanopoulou, Aristea S.; Holmes, Gregory L.; Jensen, Frances E.; Kanner, Andres M.; O’Brien, Terence J.; Whittemore, Vicky H.; Winawer, Melodie R.; Patel, Manisha; Scharfman, Helen E.

    2014-01-01

    Summary Many symptoms of neurologic or psychiatric illness—such as cognitive impairment, depression, anxiety, attention deficits, and migraine—occur more frequently in people with epilepsy than in the general population. These diverse comorbidities present an underappreciated problem for people with epilepsy and their caregivers because they decrease quality of life, complicate treatment, and increase mortality. In fact, it has been suggested that comorbidities can have a greater effect on quality of life in people with epilepsy than the seizures themselves. There is increasing recognition of the frequency and impact of cognitive and behavioral comorbidities of epilepsy, highlighted in the 2012 Institute of Medicine report on epilepsy. Comorbidities have also been acknowledged, as a National Institutes of Health (NIH) Benchmark area for research in epilepsy. However, relatively little progress has been made in developing new therapies directed specifically at comorbidities. On the other hand, there have been many advances in understanding underlying mechanisms. These advances have made it possible to identify novel targets for therapy and prevention. As part of the International League Against Epilepsy/American Epilepsy Society workshop on preclinical therapy development for epilepsy, our working group considered the current state of understanding related to terminology, models, and strategies for therapy development for the comorbidities of epilepsy. Herein we summarize our findings and suggest ways to accelerate development of new therapies. We also consider important issues to improve research including those related to methodology, nonpharmacologic therapies, biomarkers, and infrastructure. PMID:23909853

  15. Complexity Triggered by Economic Globalisation— The Issue of On-Line Betting-Related Match Fixing

    Directory of Open Access Journals (Sweden)

    Wladimir Andreff

    2017-02-01

    Full Text Available Complexity in mainstream economics consists in high intermediary consumption of mathematics. A new approach to complexity economics dwells upon path-dependent global systems; their emergence and evolving organisation. The focus here is on the complexity of the real economic world due to globalisation. On-line betting related match-fixing is a case in point about which the article presents non-exhaustive empirical evidence and shows how it is analysed with the standard model of the economics of crime. There is no room for complexity in such an individualistic approach to corrupt behaviour applied to bet-related fixes. A more complex model is sketched based on interactions between a global (though underground market for fixes and the actual partly legal, partly illegal global sport betting market. These interactions exhibit how complex is the issue of combating betting-related match fixing. Reviewing those major policies envisaged for containing the latter—prohibition; sanctions; regulation; privatisation (betting rights—the article opts for a global ‘Sportbettobin’ tax on sport betting gains; in the same vein as the famous Tobin tax on international capital transfers. The novelty in this approach is a variable (increasing rate applied to increasing tranches of taxation (gains which should dry up the worst cases of on-line bettingrelated match fixing.

  16. A study on strengthening measures of non-proliferation regime through the export control system of sensitive materials, equipment and technology related to nuclear activities

    International Nuclear Information System (INIS)

    Kikuchi, Masahiro; Kurosawa, Mitsuru; Komizo, Yasuyoshi

    2004-01-01

    The strengthened safeguards caused from safeguards experiences to Iraq and DPRK leads to the expansion of the IAEA's activities for verification of all nuclear activities as well as verification of nuclear material in the States. The purpose of the activities, of course, includes detection of undeclared exports and imports of specified equipment and non-nuclear material. The Additional Protocol to the agreements between States and the IAEA for the application of safeguards requires to the States to declare the exports and imports information regarding specified equipment and non-nuclear material corresponding to the export control list that is established by the nuclear suppliers group. The Additional Protocol also insists the IAEA's right to access to the location identified by the State to resolve a question related to the declarations. Recently, the IAEA detected the black market group of the sensitive materials, equipment and technologies relevant to the nuclear proliferation through the safeguards activities to Iran and Libya. International community stated deeply concerns to the indecent facts. This paper would discuss and propose the supplemental strengthening measures of non-proliferation regime by effective combination of the safeguards activities under additional protocol and the export control regime. (author)

  17. Evaluation of systems interactions in nuclear power plants: Technical findings related to Unresolved Safety Issue A-17

    International Nuclear Information System (INIS)

    Thatcher, D.

    1989-05-01

    This report presents a summary of the activities related to Unresolved Safety Issue (USI)A-17, ''Systems Interactions in Nuclear Power Plants,'' and also includes the NRC staff's conclusions based on those activities. The staff's technical findings provide the framework for the final resolution of this unresolved safety issue. The final resolution will be published later as NUREG-1229. 52 refs., 4 tabs

  18. Control of cell proliferation, endoreduplication, cell size, and cell death by the retinoblastoma-related pathway in maize endosperm

    KAUST Repository

    Sabelli, Paolo A.; Liu, Yan; Dante, Ricardo Augusto; Lizarraga, Lucina E.; Nguyen, Hong N.; Brown, Sara W.; Klingler, John; Yu, Jingjuan; LaBrant, Evan; Layton, Tracy M.; Feldman, Max; Larkins, Brian A.

    2013-01-01

    , and programmed cell death. Although manipulation of these processes could maximize grain yield, how they are regulated and integrated is poorly understood. We show that the Retinoblastoma-related (RBR) pathway controls key aspects of endosperm development

  19. Strengthening the non proliferation regime: French views

    International Nuclear Information System (INIS)

    Delaune, P.

    2013-01-01

    3 main issues can be identified in the French policy concerning the backing of non proliferation: 1) responding resolutely to proliferation crises, 2) reinforcing substantive efforts to prevent and impede proliferation, and 3) strengthening the non-proliferation regime. The first issue is very important because combating proliferation is vital to the security of all. Concerning the second issue, France attaches particular importance to strengthening specific measures to prevent and check proliferation. Let me mention a few proposals that we put forward: exports need to be controlled more effectively, proliferation activities have to be criminalized, or the development of proliferation-resistant technologies should be supported. Concerning the third issue it means the strengthening of the non-proliferation regime, France proposes several means: -) aiming at the universalization of the additional protocol; -) ensuring that the Agency continues to have sufficient human, financial and technical resources to fulfill its verification mission effectively; -) encouraging the IAEA to make full use of the authority available to it; -) enhancing the use of information relevant to the delivery of the IAEA mandate; and -) sharing more accurate information concerning the breaches of commitments that happen. The paper is followed by the slides of the presentation. (A.C.)

  20. Resolution of issues related to alternative RCS injection in the absence of containment sump recirculation

    International Nuclear Information System (INIS)

    Charles L Kling; Stephen S Barshay; Mathew C Jacob; Michael J Friedman

    2005-01-01

    Full text of publication follows: On June 9, 2003 the US NRC issued Bulletin No. 2003-01 that deals with the potential impact of debris blockage on containment sump recirculation at PWRs during a Loss-of-Coolant Accident (LOCA). In response to the bulletin, the Omaha Public Power District (OPPD) is in the process of developing procedural and operational strategies for their Fort Calhoun Station (FCS) to address the issues raised. Westinghouse provided engineering support to OPPD in identifying and resolving issues related to alternative means of supplying safety injection water to the reactor coolant system (RCS) in the absence of containment sump recirculation. Nuclear power plants are designed to protect the core following a LOCA by providing a continuous supply of cooling water to the core. In the long term, the Refueling Water Storage Tank (RWST) inventory will be depleted and core heat removal accomplished via recirculation of water previously injected into the Reactor Coolant System (RCS) and collected in the containment sump. Debris generated within the containment as a result of the impingement of fluid jets in the Zone of Influence (ZOI) of the RCS break and containment wash down may find its way into the containment sump. As the safety injection pumps take suction from the sump, in the recirculation mode of operation, the debris suspended in the sump water could begin to accumulate in the sump screen that is located in the recirculation path. Should sufficient debris accumulate on the sump screen, a flow blockage could potentially develop. This would result in insufficient safety injection pump NPSH, thereby impairing the recirculation mode of injection into RCS. Potential debris blockage and prevention of sump recirculation may be addressed by refilling the RWST with water and injecting this water directly into the core. This paper identifies and attempts to resolve several issues related to this alternative mode of RCS injection. In particular, the

  1. miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Wang, Chun-Mei; Wang, Yan; Fan, Chun-Guang; Xu, Fei-Fei; Sun, Wen-Sheng; Liu, Yu-Gang; Jia, Ji-Hui

    2011-01-01

    Highlights: → miR-29c was significantly downregulated in HBV-related HCC. → TNFAIP3 was found to be inversely correlated with miR-29c levels and identified as a target of miR-29c. → Overexpression of miR-29c suppressed TNFAIP3. → miR-29c inhibited HBV DNA replication, cell proliferation and induced apoptosis. -- Abstract: Recent studies have revealed that microRNA-29c (miR-29c) is involved in a variety of biological processes including carcinogenesis. Here, we report that miR-29c was significantly downregulated in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) cell lines as well as in clinical tissues compared with their corresponding controls. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), a key regulator in inflammation and immunity, was found to be inversely correlated with miR-29c levels and was identified as a target of miR-29c. Overexpression of miR-29c in HepG2.2.15 cells effectively suppressed TNFAIP3 expression and HBV DNA replication as well as inhibited cell proliferation and induced apoptosis. We conclude that miR-29c may play an important role as a tumor suppressive microRNA in the development and progression of HBV-related HCC by targeting TNFAIP3. Thus miR-29c and TNFAIP3 represent key diagnostic markers and potential therapeutic targets for the prevention and treatment of HBV infection.

  2. miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Chun-Mei [Department of Microbiology, Shandong University School of Medicine, Jinan 250012 (China); Department of Pathophysiology, Shandong University School of Medicine, Jinan 250012 (China); Wang, Yan; Fan, Chun-Guang; Xu, Fei-Fei [Department of Pathophysiology, Shandong University School of Medicine, Jinan 250012 (China); Sun, Wen-Sheng [Institute of Immunology, Shandong University School of Medicine, Jinan 250012 (China); Liu, Yu-Gang, E-mail: liu.yugang@sdu.edu.cn [Department of Pathophysiology, Shandong University School of Medicine, Jinan 250012 (China); Jia, Ji-Hui, E-mail: jiajihui@sdu.edu.cn [Department of Microbiology, Shandong University School of Medicine, Jinan 250012 (China)

    2011-08-05

    Highlights: {yields} miR-29c was significantly downregulated in HBV-related HCC. {yields} TNFAIP3 was found to be inversely correlated with miR-29c levels and identified as a target of miR-29c. {yields} Overexpression of miR-29c suppressed TNFAIP3. {yields} miR-29c inhibited HBV DNA replication, cell proliferation and induced apoptosis. -- Abstract: Recent studies have revealed that microRNA-29c (miR-29c) is involved in a variety of biological processes including carcinogenesis. Here, we report that miR-29c was significantly downregulated in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) cell lines as well as in clinical tissues compared with their corresponding controls. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), a key regulator in inflammation and immunity, was found to be inversely correlated with miR-29c levels and was identified as a target of miR-29c. Overexpression of miR-29c in HepG2.2.15 cells effectively suppressed TNFAIP3 expression and HBV DNA replication as well as inhibited cell proliferation and induced apoptosis. We conclude that miR-29c may play an important role as a tumor suppressive microRNA in the development and progression of HBV-related HCC by targeting TNFAIP3. Thus miR-29c and TNFAIP3 represent key diagnostic markers and potential therapeutic targets for the prevention and treatment of HBV infection.

  3. Rab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex

    Directory of Open Access Journals (Sweden)

    Jihui Lin

    2017-08-01

    Full Text Available Classical swine fever virus (CSFV is a fatal pig pestivirus and causes serious financial losses to the pig industry. CSFV NS4B protein is one of the most important viral replicase proteins. Rab5, a member of the small Rab GTPase family, is involved in infection and replication of numerous viruses including hepatitis C virus and dengue virus. Until now, the effects of Rab5 on the proliferation of CSFV are poorly defined. In the present study, we showed that Rab5 could enhance CSFV proliferation by utilizing lentivirus-mediated constitutive overexpression and eukaryotic plasmid transient overexpression approaches. On the other hand, lentivirus-mediated short hairpin RNA knockdown of Rab5 dramatically inhibited virus production. Co-immunoprecipitation, glutathione S-transferase pulldown and laser confocal microscopy assays further confirmed the interaction between Rab5 and CSFV NS4B protein. In addition, intracellular distribution of NS4B-Red presented many granular fluorescent signals (GFS in CSFV infected PK-15 cells. Inhibition of basal Rab5 function with Rab5 dominant negative mutant Rab5S34N resulted in disruption of the GFS. These results indicate that Rab5 plays a critical role in facilitating the formation of the NS4B related complexes. Furthermore, it was observed that NS4B co-localized with viral NS3 and NS5A proteins in the cytoplasm, suggesting that NS3 and NS5A might be components of the NS4B related complex. Taken together, these results demonstrate that Rab5 positively modulates CSFV propagation and interacts with NS4B protein to facilitate the NS4B related complexes formation.

  4. Regulatory compliance issues related to the White Oak Creek Embayment time-critical removal action

    International Nuclear Information System (INIS)

    Leslie, M.; Kimmel, B.L.

    1992-01-01

    In September 1990, Martin Marietta Energy Systems (Energy Systems) discovered high levels of Cesium-137 present in surface sediments at the mouth of White Oak Creek (WOC) Embayment. WOC receives the majority of surface water drainage from Oak Ridge National Laboratory. Following this discovery, the Department of Energy (DOE) and Energy Systems pursued stabilizing sediment migration under provisions of the National Contingency Plan (NCP) Section 300.400 et. seq. as a time-critical removal action. However, significant uncertainty exists concerning the applicability of NCP procedural requirements designed for conducting US EPA-led, Superfund-financed response actions, because NCP Subpart K dealing with response actions at federal facilities has not been promulgated. In addition, relatively new guidance exists from DOE concerning National Environmental Policy Act documentation requirements for categorical exclusions associated with conducting removal actions at DOE facilities. A proactive approach was taken to identify issues and involve appropriate state and federal regulatory agencies. This approach required achieving consensus among all involved parties and identification of all applicable or relevant and appropriate regulatory requirements related to the removal action. As a result, this project forms a framework for conducting future time-critical removal actions at federal facilities

  5. Bisphosphonate-related osteonecrosis of the jaw: historical, ethical, and legal issues associated with prescribing.

    Science.gov (United States)

    Faiman, Beth; Pillai, Aiswarya Lekshmi Pillai Chandran; Benghiac, Ana Gabriela

    2013-01-01

    The long-term effects of many drugs are unknown. Established risks are communicated to patients who participate in clinical trials during the informed consent process. However, unknown and unanticipated side effects of medications may occur years after treatment. Patients with metastatic bone cancer experience an imbalance between tumor cells and the bone marrow microenvironment. Increased cytokine release, osteoclastic activity, and uncoupled osteoblastic activity lead to weakened bone structure and osteolytic lesions. The bisphosphonates are a class of drugs available in IV and oral formulations to treat and prevent bone loss and decrease the risk of skeletal-related events. Intravenous bisphosphonates such as zoledronic acid and pamidronate disodium are approved by the US Food and Drug Administration for the treatment of bone pain and hypercalcemia of malignancy and the prevention of painful bone fractures in patients with metastatic bone cancer. Oral bisphosphonates such as alendronate, risedronate, and etidronate are used to reduce the risk of skeletal fractures in patients with osteoporosis and in breast cancer. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a rare but painful complication of treatment characterized by infection, exposed bone, and poor wound healing. In this article, we discuss BRONJ and identify past, present, and future ethical and legal issues surrounding bisphosphonate administration.

  6. Application of Radiation Chemistry to Some Selected Technological Issues Related to the Development of Nuclear Energy.

    Science.gov (United States)

    Bobrowski, Krzysztof; Skotnicki, Konrad; Szreder, Tomasz

    2016-10-01

    The most important contributions of radiation chemistry to some selected technological issues related to water-cooled reactors, reprocessing of spent nuclear fuel and high-level radioactive wastes, and fuel evolution during final radioactive waste disposal are highlighted. Chemical reactions occurring at the operating temperatures and pressures of reactors and involving primary transients and stable products from water radiolysis are presented and discussed in terms of the kinetic parameters and radiation chemical yields. The knowledge of these parameters is essential since they serve as input data to the models of water radiolysis in the primary loop of light water reactors and super critical water reactors. Selected features of water radiolysis in heterogeneous systems, such as aqueous nanoparticle suspensions and slurries, ceramic oxides surfaces, nanoporous, and cement-based materials, are discussed. They are of particular concern in the primary cooling loops in nuclear reactors and long-term storage of nuclear waste in geological repositories. This also includes radiation-induced processes related to corrosion of cladding materials and copper-coated iron canisters, dissolution of spent nuclear fuel, and changes of bentonite clays properties. Radiation-induced processes affecting stability of solvents and solvent extraction ligands as well oxidation states of actinide metal ions during recycling of the spent nuclear fuel are also briefly summarized.

  7. Economy, Geopolitics, environment: the triple gas issue in the relations between the Eu and Russia

    International Nuclear Information System (INIS)

    Bourguignon, D.

    2008-01-01

    With the political tinge it has recently acquired, natural gas has taken a central position in the relations between the EU and Russia Besides energy security, the issue has three levels: the first is the opening of markets or the maintaining of monopolies, as much in Russia as in the European Union. The line of fracture is complex, and at present, in spite of rhetoric support on the opening of markets, it is rather their protection which is on the agenda. The second level is that of energy diplomacy Brussels and Moscow come face to face primarily in Central Asia, on the basis of interests and using diametrically opposite instrument. However, their policies are characterised by weighty constraints. The third level is that of the fight against climatic change. Soaring in this field, there are several convergencies between the policies of Brussels and Moscow, particularly in terms of energy efficiency. With this new order, gas could watch itself grow in significance, or otherwise drop, in which case the relation between the EU and Russian would not go uninfluenced. (author)

  8. Summary of tank information relating salt well pumping to flammable gas safety issues

    International Nuclear Information System (INIS)

    Caley, S.M.; Mahoney, L.A.; Gauglitz, P.A.

    1996-09-01

    The Hanford Site has 149 single-shell tanks (SSTs) containing radioactive wastes that are complex mixes of radioactive and chemical products. Active use of these SSTs was phased out completely by November 1980, and the first step toward final disposal of the waste in the SSTs is interim stabilization, which involves removing essentially all of the drainable liquid from the tank. Stabilization can be achieved administratively, by jet pumping to remove drainable interstitial liquid, or by supernatant pumping. To date, 116 tanks have been declared interim stabilized; 44 SSTs have had drainable liquid removed by salt well jet pumping. Of the 149 SSTs, 19 are on the Flammable Gas Watch List (FGWL) because the waste in these tanks is known or suspected, in all but one case, to generate and retain mixtures of flammable gases, including; hydrogen, nitrous oxide, and ammonia. Salt well pumping to remove the drainable interstitial liquid from these SSTs is expected to cause the release of much of the retained gas, posing a number of safety concerns. The scope of this work is to collect and summarize information, primarily tank data and observations, that relate salt well pumping to flammable gas safety issues. While the waste within FGWL SSTs is suspected offering flammable gases, the effect of salt well pumping on the waste behavior is not well understood. This study is being conducted for the Westinghouse Hanford Company as part of the Flammable Gas Project at the Pacific Northwest National Laboratory (PNNL). Understanding the historical tank behavior during and following salt well pumping will help to resolve the associated safety issues

  9. Pakistan's Nuclear Weapons: Proliferation and Security Issues

    National Research Council Canada - National Science Library

    Kerr, Paul; Nikitin, Mary B

    2007-01-01

    Pakistan's nuclear arsenal consists of approximately 60 nuclear warheads. Pakistan continues fissile material production for weapons, and is adding to its weapons production facilities and delivery vehicles...

  10. Proliferation of Precision Strike: Issues for Congress

    Science.gov (United States)

    2012-05-14

    industrial base. Finally, should Congress legislate requirements for DOD to develop precision strike countermeasures and then provide funding for that...Defense, Part 187 – Environmental Effects Abroad of Major Department of Defense Actions, Section 187.3: Definitions. 32 Bryan Clark and Dan Whiteneck...so many missiles ... referring to reports of Venezuelan arms flowing to Colombian guerrillas.... The Chavez regime also has close ties with

  11. An overview of economic and technical issues related to LWR MOX fuel usage

    International Nuclear Information System (INIS)

    Malone, J.P.; Varley, G.; Goldstein, L.

    1999-01-01

    This paper will present comparisons of the economics of MOX versus UO 2 fuels. In addition to the economics of the front end, the scope of the comparison will include the back end of the fuel cycle. Management of spent MOX fuel assemblies presents utilities with some technical issues that can complicate spent fuel pool operation. Alternative spent fuel management methods, such as dry storage of spent MOX fuel assemblies, will also be discussed. Differences in decay heat loads versus time for spent MOX and UO 2 fuel assemblies will be presented. This difference is one of the main problems confronting spent fuel managers relative to MOX. The difference in decay heat loads will serve as the basis for a performance overview of the various spent fuel technologies available today. The economics of the front end of MOX will be presented relative to UO 2 fuel. Availability of MOX manufacturing capability will also be discussed, along with a discussion of its impact on future MOX fabrication prices. The in-core performance of MOX will be compared to that of UO 2 fuel with similar performance characteristics. The information will include highlights of nuclear design and related operational considerations such as: Reactivity reduction with burnup is slower for MOX fuel than for UO 2 fuel; Spectral hardening resulting in lower control rod worths and a lower soluble boron worth; and more negative moderator, void and fuel temperature coefficients. A comparison of Westinghouse and ABB-CE core designs for use on disposition of weapons MOX in 12- and 18-month cycles will be presented. (author)

  12. Issues of work intensity, pace, and sustainability in relation to work context and nutritional status.

    Science.gov (United States)

    Panter-Brick, Catherine

    2003-01-01

    This article raises issues about work intensity, pace, and sustainability during physical activity, focusing attention on the nature of work in labor-intensive societies, the management of exertion in habitual tasks, and the health and broad socioeconomic correlates of alternative ways to regulate work patterns. At the heart of this review are concerns to document human adaptability (in terms of the physical and behavioral management of heavy work) and to renew debate regarding the conceptualization and measurement of work intensity (variously evaluated in absolute or relative terms, as indexed by oxygen consumption, energy expenditure, percentage maximal work capacity, heart rate elevation, time and motion indicators, or physiological cost). Three questions are examined: Is heavy work primarily a matter of time or energy intensity? How is heavy work habitually sustained? What is the bigger picture relating work performance to work context and to nutritional or health status? It is argued that many arduous activities, such as carrying loads, demand endurance over time rather than intensive effort per unit time, and that work pace management lies in regulating both the rate of work and the time in rest during physical activity. Furthermore, strategies that maximize long-term endurance (adopted by "tortoises") and those that maximize short-term productivity (adopted by "hares") are appropriate to different work contexts (e.g., a subsistence or wage-labor economy) and suit individuals with different health status and ability. Thus, work intensity is an important aspect of the links between physical activity, health, productivity, and society, as noted in literature reviewing objectives for sustainable development and public health messages for disease risk management. These areas of scholarship are underresearched, partly because consensus has been slow in agreeing on which are the best measures of work pace and work intensity for use in field situations, and which

  13. Non-proliferation

    International Nuclear Information System (INIS)

    Deiseroth, D.; Gustafsson, S.

    1993-01-01

    The issue of Nuclear Non Proliferation has been moved to a leading place on the contemporary international security agenda. What about the situation of nuclear weapons and nuclear technology in Russia, Kazakhstan, Ukraine and Belorussia? Why did the IAEA-inspectors totally failed to discover any sign of Iraq's clandestine nuclear-weapon programme before the Gulf War? Do the NATO and their nuclear power states violate Art. VI of the Non-Proliferation-Treaty (NPT), because they are - despite the end of the cold war - not willing to renounce of the ''option of the first use of nuclear weapons''? Does the NPT establish a form of nuclear apartheid? What will be the situation if the NPT-Extension-Conference in 1995 will be unable to obtain a majority of the parties for any one extension proposal? Do we need a new international nuclear control agency with severe powers, a sort of nuclear Interpol? The Colloquium ''Saving NPT and abolishing Nuclear Weapons'', held in Stockholm in September 1992, organized by the Swedish and the German Sections of IALANA, tried to analyse some of the raised issues. (orig.) [de

  14. Low-intensity pulsed ultrasound stimulates cell proliferation, proteoglycan synthesis and expression of growth factor-related genes in human nucleus pulposus cell line

    Directory of Open Access Journals (Sweden)

    Y Kobayashi

    2009-06-01

    Full Text Available Low-intensity pulsed ultrasound (LIPUS stimulation has been shown to effect differentiation and activation of human chondrocytes. A study involving stimulation of rabbit disc cells with LIPUS revealed upregulation of cell proliferation and proteoglycan (PG synthesis. However, the effect of LIPUS on human nucleus pulposus cells has not been investigated. In the present study, therefore, we investigated whether LIPUS stimulation of a human nucleus pulposus cell line (HNPSV-1 exerted a positive effect on cellular activity. HNPSV-1 cells were encapsulated in 1.2% sodium alginate solution at 1x105 cells/ml and cultured at 10 beads/well in 6-well plates. The cells were stimulated for 20 min each day using a LIPUS generator, and the effects of LIPUS were evaluated by measuring DNA and PG synthesis. Furthermore, mRNA expression was analyzed by cDNA microarray using total RNA extracted from the cultured cells. Our study revealed no significant difference in cell proliferation between the control and the ultrasound treated groups. However, PG production was significantly upregulated in HNPSV cells stimulated at intensities of 15, 30, 60, and 120 mW/cm2 compared with the control. The results of cDNA array showed that LIPUS significantly stimulated the gene expression of growth factors and their receptors (BMP2, FGF7, TGFbetaR1 EGFRF1, VEGF. These findings suggest that LIPUS stimulation upregulates PG production in human nucleus pulposus cells by the enhancement of several matrix-related genes including growth factor-related genes. Safe and non-invasive stimulation using LIPUS may be a useful treatment for delaying the progression of disc degeneration.

  15. Vocational technical and adult education: Status, trends and issues related to electronic delivery

    Science.gov (United States)

    Rothenberg, D.

    1973-01-01

    Data are analyzed, and trends and issues are discussed to provide information useful to the systems designer who wishes to identify and assess the opportunities for large scale electronic delivery in vocational/technical and adult education. Issues connected with vocational/technical education are investigated, with emphasis on those issues in the current spotlight which are relevant to the possibilities of electronic delivery. The current role of media is examined in vocational/technical instruction.

  16. Nuclear power and nuclear-weapons proliferation

    International Nuclear Information System (INIS)

    Moniz, E.J.; Neff, T.L.

    1978-01-01

    Concern over the risk of nuclear proliferation has led to extensive reexamination of the technical, economic, and political assumptions underlying both national and international nuclear policies. An attempt is made in the present article to clarify the basic technical and political issues. The connections between various fuel cycles and their possible proliferation risks are discussed. As the resolution of the existing differing views on proliferation risks will be largely a political process, solutions to the problem are not proposed

  17. Doubly-Special Relativity: Facts, Myths and Some Key Open Issues

    Directory of Open Access Journals (Sweden)

    Giovanni Amelino-Camelia

    2010-03-01

    Full Text Available I report, emphasizing some key open issues and some aspects that are particularly relevant for phenomenology, on the status of the development of “doubly-special” relativistic (“DSR” theories with both an observer-independent high-velocity scale and an observer-independent small-length/large-momentum scale, possibly relevant for the Planck-scale/quantum-gravity realm. I also give a true/false characterization of the structure of these theories. In particular, I discuss a DSR scenario without modification of the energy-momentum dispersion relation and without the қ-Poincaré Hopf algebra, a scenario with deformed Poincaré symmetries which is not a DSR scenario, some scenarios with both an invariant length scale and an invariant velocity scale which are not DSR scenarios, and a DSR scenario in which it is easy to verify that some observable relativistic (but non-special-relativistic features are insensitive to possible nonlinear redefinitions of symmetry generators.

  18. Issues and recommendations related to replacement of CFC-114 at the uranium enrichment gaseous diffusion plant

    International Nuclear Information System (INIS)

    Anderson, B.L.; Banaghan, E.

    1993-01-01

    The operating uranium enrichment gaseous diffusion plants (GDPs) in Portsmouth, Ohio and Paducah, Kentucky, which are operated for the United States Department for Energy by Martin Marietta Energy Systems (MMES), currently use a chlorofluorocarbon (CFC-114) as the primary process stream coolant. Due to recent legislation embodied in the Clean Air Act, the production of this and other related chlorofluorocarbons (CFCS) are to be phased out with no production occurring after 1995. Since the plants lose approximately 500,000 pounds per year of this process stream coolant through various leaks, the GDPs are faced with the challenge of identifying a replacement coolant that will allow continued operation of the plants. MMES formed the CFC Task Team to identify and solve the various problems associated with identifying and implementing a replacement coolant. This report includes a review of the work performed by the CFC Task Team, and recommendations that were formulated based on this review and upon original work. The topics covered include; identifying a replacement coolant, coolant leak detection and repair efforts, coolant safety concerns, coolant level sensors, regulatory issues, and an analytical decision analysis

  19. Xylitol: a review on bioproduction, application, health benefits, and related safety issues.

    Science.gov (United States)

    Ur-Rehman, Salim; Mushtaq, Zarina; Zahoor, Tahir; Jamil, Amir; Murtaza, Mian Anjum

    2015-01-01

    Xylitol is a pentahydroxy sugar-alcohol which exists in a very low quantity in fruits and vegetables (plums, strawberries, cauliflower, and pumpkin). On commercial scale, xylitol can be produced by chemical and biotechnological processes. Chemical production is costly and extensive in purification steps. However, biotechnological method utilizes agricultural and forestry wastes which offer the possibilities of economic production of xylitol by reducing required energy. The precursor xylose is produced from agricultural biomass by chemical and enzymatic hydrolysis and can be converted to xylitol primarily by yeast strain. Hydrolysis under acidic condition is the more commonly used practice influenced by various process parameters. Various fermentation process inhibitors are produced during chemical hydrolysis that reduce xylitol production, a detoxification step is, therefore, necessary. Biotechnological xylitol production is an integral process of microbial species belonging to Candida genus which is influenced by various process parameters such as pH, temperature, time, nitrogen source, and yeast extract level. Xylitol has application and potential for food and pharmaceutical industries. It is a functional sweetener as it has prebiotic effects which can reduce blood glucose, triglyceride, and cholesterol level. This review describes recent research developments related to bioproduction of xylitol from agricultural wastes, application, health, and safety issues.

  20. Modelling approaches to thermal pollution in inland aquatic systems and issues related to its environmental impacts

    International Nuclear Information System (INIS)

    Mahadevan, T.N.; Nair, R.N.; Sadasivan, S.

    2002-01-01

    Guidelines for the safe discharge of thermal effluents in aquatic environmental systems both surface water and marine coastal out falls has become very relevant to Indian environmental conditions with its rich biodiversity. While aquatic ecology may form the basis for such guidelines, the need for regulatory approach to the related issues has become the prime mover in thermal discharge problems. This is more so since the impacts considered are under short term and long term exposure conditions where the bio acclimatization and thermal stress factors may come to cross roads. Constant temperatures and cyclic temperature elevations also causes differential thermal stress which could be site specific. The recent notification by the Ministry of Environment and Forest (MoEF) revising the temperature limit for discharge of condenser cooling water from thermal power plants into coastal areas using sea water from 5 deg to 7 degC over and above the ambient temperature of the receiving water bodies. Discussions on whether the limiting temperature is to be achieved at the point of discharge or within a specified zone of the thermal plume is currently being debated. The act also stipulates installation of cooling towers using water from rivers, lakes and reservoirs irrespective of the plant location and capacity. For existing thermal plants the rise in temperature of the condenser cooling water from inlet to the let of the condenser shall not be more than 10 degC. (author)

  1. Containment Emergency Sump Performance. Technical findings related to Unresolved Safety Issue A-43. Revision 1

    International Nuclear Information System (INIS)

    1985-10-01

    This report summarizes key technical findings related to Unresolved Safety Issue (USI) A-43, Containment Emergency Sump Performance. Both BWRs and PWRs are considered in this report. Emergency core cooling systems require a clean, reliable water source to maintain long-term recirculation following a loss-of-coolant accident (LOCA). PWRs rely on the containment emergency sump to provide such a water supply to residual heat removal pumps and containment spray pumps. BWRs rely on pump suction intakes in the suppression pool or wet well to provide water to residual heat removal and core spray systems. Thus, the technical findings in this report provide information on post-LOCA recirculation. These findings have been derived from extensive experimental studies, generic plant studies, and assessments of sumps used for long-term cooling. Results of hydraulic tests have shown that the potential for air ingestion is less severe than previously hypothesized. The effects of debris blockage on NPSH margin must be dealt with on a plant-specific basis. These findings have been used to develop revisions to Regulatory Guide 1.82 and Standard Review Plan Section 6.2.2 (NUREG-0800)

  2. Something fishy? News media presentation of complex health issues related to fish consumption guidelines.

    Science.gov (United States)

    Greiner, Amelia; Clegg Smith, Katherine; Guallar, Eliseo

    2010-11-01

    The news media are an important source of dietary information. Understanding news content, particularly the portrayal of risks and benefits of certain foods, is relevant for effective public health communication. Fish consumption may reduce risk for CVD and aid neonatal development, but recent work shows public confusion about the benefits of fish, challenged by the evidence of mercury and other contaminants in fish. We present an analysis of the messages about fish in US news media over 15 years, identifying trends in coverage and highlighting implications of current messaging. We conducted a descriptive text analysis and coded for manifest content: locality of focus, story frame, reference to studies, inclusion of government guidelines and portrayal of uncertainty. We identified chronological patterns and analysed the data for statistically significant relationships between media source and content. News stories were selected from five daily newspapers and five television networks (1993-2007). We analysed 310 health-related news stories on fish. Risk messages outweighed benefit messages four to one, and health benefits only became prominent after 2002. No difference existed in coverage topic by news source. Fish consumption has increasingly become a national issue. With the bulk of messages about fish consumption focused on risk, the benefits may be lost to consumers. This gap creates a need for public health to work with news media to more effectively communicate benefits and risks around fish consumption and health and to consider options for communicating tailored information where it can be more readily utilised.

  3. Evaluation of the performance of diagnosis-related groups and similar casemix systems: methodological issues.

    Science.gov (United States)

    Palmer, G; Reid, B

    2001-05-01

    With the increasing recognition and application of casemix for managing and financing healthcare resources, the evaluation of alternative versions of systems such as diagnosis-related groups (DRGs) has been afforded high priority by governments and researchers in many countries. Outside the United States, an important issue has been the perceived need to produce local versions, and to establish whether or not these perform more effectively than the US-based classifications. A discussion of casemix evaluation criteria highlights the large number of measures that may be used, the rationale and assumptions underlying each measure, and the problems in interpreting the results. A review of recent evaluation studies from a number of countries indicates that considerable emphasis has been placed on the predictive validity criterion, as measured by the R2 statistic. However, the interpretation of the findings has been affected greatly by the methods used, especially the treatment and definition of outlier cases. Furthermore, the extent to which other evaluation criteria have been addressed has varied widely. In the absence of minimum evaluation standards, it is not possible to draw clear-cut conclusions about the superiority of one version of a casemix system over another, the need for a local adaptation, or the further development of an existing version. Without the evidence provided by properly designed studies, policy-makers and managers may place undue reliance on subjective judgments and the views of the most influential, but not necessarily best informed, healthcare interest groups.

  4. Legal Issues Related to Donation of Organs, Tissues and Cells of Human Origin

    Directory of Open Access Journals (Sweden)

    Gabriela Mironov

    2010-06-01

    Full Text Available Scientific developments, positive changes in attitude of the man and the new legal framework allow the donation of organs, tissues and cells of human origin. In this context it is necessary to clarifywhether the donation covered by the special law is, legally, one and the same as that covered by the Romanian Civil Code in force and qualified the successor’s right to accept or reject late withdrawals for transplantation. The right to life and physical integrity is personal patrimony; it is a subjective civil right that has no economic content and it cannot be measured in money. Consequently, the content of these rights can not be expressed in money, the property does not belong to their owner. Given the above view, "the right of disposal" to donation of organs, tissues and cells of human origin is an attribute of ownership, right to life and physical integrity, as a personal right that is an intimate attribute patrimonial related to the person’s right to dispose of his body as it wishes, within the law. Addressing these issues it is necessary to clarify the legal consequences of donating organs, tissues and cells of human origin, considering that medical activities are becoming more numerous.

  5. Monitoring, Tracking, and Recording Pancreas-Related Health Issues in Real Time

    Science.gov (United States)

    Chrysikos, Theofilos; Zisi, Iliana; Katsini, Christina; Raptis, George E.; Kotsopoulos, Stavros

    2017-11-01

    The monitoring of pancreas-related health issues in real-time and outside the medical room is a challenge in the wide e-health domain. This paper introduces WHEAMO, a novel e-health platform which employs medical implants (biosensors), which function as antennas, planted in the pancreas. WHEAMO uses wireless in-body propagation to track, monitor, and record critical parameters, such as glucose. The signal reaches the skin and then it is propagated in an indoor environment (e.g., medical room) over to a terminal equipped with adaptive, user-configurable, and intelligent mechanisms which provide personalized recommendations to varying WHEAMO users (e.g., medical personnel, health care workers, patients). The personalized nature of the provided recommendations is based on patients unique characteristics via a sophisticated knowledge-base. The fundamentals of in-body and on-body wireless propagation and channel characterization have been studied in a series of published works. Researchers have tested both electric-field (dipole) and magnetic-field (patch, loop) antennas. Another important aspect concerns the frequency band in which the signal propagation will occur. Among the frequencies that have gathered scientific and academic interest are the Medical Implant Communication Service (MICS) band at 402-405 MHz, the 900 MHz channel and the industrial, scientific and medical (ISM) radio band at 2.45 GHz.

  6. Gender Issues and Related Social Stigma Affecting Patients with a Disorder of Sex Development in India.

    Science.gov (United States)

    Joseph, Angela Ann; Kulshreshtha, Bindu; Shabir, Iram; Marumudi, Eunice; George, Tony Sam; Sagar, Rajesh; Mehta, Manju; Ammini, Ariachery C

    2017-02-01

    Children with disorders of sex development (DSD) manifest at birth with malformed genitalia or later with atypical pubertal development. Those born with malformed genitalia are often diagnosed at birth. However, in resource-poor countries like India, where not all births are supervised by healthcare workers, some of these children remain undiagnosed until puberty or even later. The aim of this study was to assess the gender issues and psychosocial problems of children with DSD. Participants included 205 children with DSD (103 with 46,XX DSD and 102 with 46,XY DSD). Both the children with DSD and their parents underwent semistructured interviews by a clinical psychologist. The birth of a child with DSD was perceived as a major medical and social problem by parents from all socioeconomic strata. Mothers were distressed as many believed the DSD condition was transmitted through the mother. Children who were not diagnosed and treated during infancy or early childhood experienced considerable social discrimination not only from relatives and friends but also from medical and paramedical staff in hospitals. Several patients had been operated during infancy without an etiological diagnosis and without provision of adequate information to the parents. Some children had problems related to complications of surgery. Most teenage patients with 5α-reductase-2 deficiency reared as females presented with gender dysphoria, while children with androgen insensitivity (except for one) or with gonadal dysgenesis developed a gender identity concordant with their gender of rearing. Parents of children with DSD preferred a male gender assignment for their children (if that was possible) because of the social advantages of growing up male in a patriarchal society.

  7. Public health issues related with the consumption of food obtained from genetically modified organisms.

    Science.gov (United States)

    Paparini, Andrea; Romano-Spica, Vincenzo

    2004-01-01

    Genetically Modified Organisms (GMOs) are a fact of modern agriculture and a major field of discussion in biotechnology. As science incessantly achieves innovative and unexpected breakthroughs, new medical, political, ethical and religious debates arise over the production and consumption of transgenic organisms. Despite no described medical condition being directly associated with a diet including approved GM crops in large exposed populations such as 300,000,000 Americans and a billion Chinese, public opinion seems to look at this new technology with either growing concern or even disapproval. It is generally recognized that a high level of vigilance is necessary and highly desirable, but it should also be considered that GMOs are a promising new challenge for the III Millennium societies, with remarkable impact on many disciplines and fields related to biotechnology. To acquire a basic knowledge on GMO production, GM-food consumption, GMO interaction with humans and environment is of primary importance for risk assessment. It requires availability of clear data and results from rigorous experiments. This review will focus on public health risks related with a GMO-containing diet. The objective is to summarize state of the art research, provide fundamental technical information, point out problems and perspectives, and make available essential tools for further research. Are GMO based industries and GMO-derived foods safe to human health? Can we consider both social, ethical and public health issues by means of a constant and effective monitoring of the food chain and by a clear, informative labeling of the products? Which are the so far characterized or alleged hazards of GMOs? And, most importantly, are these hazards actual, potential or merely contrived? Several questions remain open; answers and solutions belong to science, to politics and to the personal opinion of each social subject.

  8. Dynamics of proliferating powers. For a new interdisciplinary approach

    International Nuclear Information System (INIS)

    Archambault, Jean-Claude; GRAND, Camille; Pasco, Xavier; SITT, Bernard

    2002-01-01

    The authors highlight that conventional approaches to the proliferation of arms of massive destruction are not sufficient to provide a generic evaluation grid whereas such a grid is clearly needed. In a first part, they discuss the contribution of various theories of proliferation of arms of massive destruction which generally address this phenomenon through three main points of view: legal and political means of struggle against proliferation, analysis of technical capacities, and motivations of proliferating States. The authors indicate and briefly present the various associated models. Then, they develop the basis of an analytical method aimed at a better understanding of the 'proliferating power', and at using various approaches, and notably that related to leader's psychology. They comment the content of studies already published on these issues, more precisely address the psycho-sociological dimension, outline the interest of diplomacy in this psychological approach, evoke the different typologies of personality, and propose elements of a new matrix of analysis of the proliferation phenomenon which takes national resources, history and strategic context, type of political regime, history and personality typology of the leader, and international dependencies, alliances, elites and mediators of the inner power, and public opinions into account

  9. Steam generator thermal hydraulic design & functional architecture features and related operational and reliability issues requiring consideration

    International Nuclear Information System (INIS)

    Klarner, R.G.

    2012-01-01

    Proper thermal hydraulic design and functional architecture are critical to successful steam generator operation and long term reliability. The evolution of steam generators has been a gradual learning process that has benefited from continuous industry operational experience (OPEX). Inadequate thermal hydraulic design can lead to numerous degradation mechanisms such as excessive deposition, corrosion, flow and level instabilities, fluid-elastic instabilities and tube wear. The functional architecture determines the health of the tube bundle and the other internals during manufacturing, handling and operation. It also determines thermal performance as well as establishing global thermal-hydraulic characteristics such as water level shrink and swell response. This paper discusses the range of operational and reliability issues and relates them to the thermal hydraulic attributes and functional architecture of steam generators (many SG reliability issues are further discussed in other presentations at this conference). In pursuing such issues, the paper focuses on the four major features of the equipment, identifying in each case the goals and requirements such features must meet. Typical approaches and the means by which such requirements are addressed in current equipment are discussed. The four features are: 1. Tubing Material and Tube Bundle Heat Transfer Performance; a. Two materials are in current use – Alloy 690 TT and Alloy 800. Both are good materials with excellent performance records which serve their owners very well (the reliability attributes of Alloy 800 and 690 are discussed in other papers at this conference). Caution is advised in the supply of any material: – material quality is only assured by what is specified to material suppliers in procurement specifications – i.e. - all the knowledge and research in the world assures nothing if its findings are not reflected in procurement requirements. b. Heat transfer performance in addition to being

  10. How Older Adults and Their Families Perceive Family Talk about Aging-Related EOL Issues: A Dialectical Analysis.

    Science.gov (United States)

    Egbert, Nichole; Child, Jeffrey T; Lin, Mei-Chen; Savery, Carol; Bosley, Tammy

    2017-04-17

    For older adults, approaching end-of-life (EOL) brings unique transitions related to family relationships. Unfortunately, most families greatly underestimate the need to discuss these difficult issues. For example, parents approaching EOL issues often struggle with receiving assistance from others, avoiding family conflict, and maintaining their sense of personhood. In addition, discussions of EOL issues force family members to face their parents' mortality, which can be particularly difficult for adult children to process emotionally. This study explored aging issues identified by aging parents and their families as they traverse these impending EOL changes. Ten focus groups of seniors ( n = 65) were conducted. Focus groups were organized according to race (African-American/European-American), gender, and whether the older adult was living independently or in an assisted care facility. When asked open-ended questions about discussing aging and EOL issues with family members, participants revealed tensions that led us to consider Relational Dialectics Theory as a framework for analysis. The predominant tension highlighted in this report was certainty versus uncertainty, with the two sub-themes of sustained life versus sustained personhood and confronting versus avoiding EOL issues. For these data, there were more similarities than differences as a result of gender, race, or living situation than one might expect, although culture and financial status were found to be influential in the avoidance of EOL discussions. The results of this study help to provide additional insight into relational dialectics related to aging, EOL, and the importance of communication in facilitating family coping.

  11. Report on the behalf of the Foreign Affairs, Defense and Armed Forces Commission on the bill project, adopted by the National Assembly, related to the struggle against the proliferation of arms of massive destruction and their vectors; Rapport fait au nom de la commission des affaires etrangeres, de la defense et des forces armees (1) sur le projet de loi, ADOPTE PAR L'ASSEMBLEE NATIONALE, relatif a la lutte contre la proliferation des armes de destruction massive et de leurs vecteurs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    This report recalls the origins of the bill project which is the implementation of the UN Security Council resolution 1540, the aim of which was to promote the setting up of efficient tools to struggle against proliferation. The bill project aims at updating and reinforcing the existing law arsenal. The report also contains remarks made by the Commission. The bill project addresses several issues: the struggle against proliferation of arms of massive destruction (nuclear weapons, nuclear materials, biological weapons, and chemical weapons), the struggle against proliferation of vectors of arms of massive destruction, double-use goods, the use of these weapons and vectors in acts of terrorism

  12. Large-scale Water-related Innovative Renewable Energy Projects and the Water Framework Directive : Legal Issues and Solutions

    NARCIS (Netherlands)

    van Hees, S.R.W.

    2017-01-01

    This article discusses two legal issues that relate to the conflict between the interest of protecting water quality under the Water Framework Directive (WFD), versus the interest of promoting the use of innovative water-related renewable energy, with regard to the quota in the Renewable Energy

  13. Large-scale Water-related Innovative Renewable Energy Projects and the Habitats and Birds Directives: Legal Issues and Solutions

    NARCIS (Netherlands)

    van Hees, S.R.W.

    This article discusses two legal issues that relate to the conflict between the interest of protecting habitats and species under the Habitats and Birds Directives, versus the interest of promoting the use of innovative water-related renewable energy, with regard to the quota in the Renewable Energy

  14. 78 FR 33843 - Request for Comments on Issues Related to Incidental Findings That Arise in the Clinical...

    Science.gov (United States)

    2013-06-05

    ... specific bioethical, legal, and social issues related to potential scientific and technological advances... related areas of science and technology. The Bioethics Commission is charged with identifying and... establishing ``no return'' policies, or stipulations in advance of clinical intervention, research, and/or...

  15. Compensation for environmental asbestos-related diseases in South Africa: a neglected issue

    Directory of Open Access Journals (Sweden)

    Ntombizodwa Ndlovu

    2013-01-01

    Full Text Available Background: Environmentally acquired asbestos-related diseases (ARDs are of concern globally. In South Africa, there is widespread contamination of the environment due to historical asbestos mining operations that were poorly regulated. Although the law makes provision for the compensation of occupationally acquired ARDs, compensation for environmentally acquired ARDs is only available through the Asbestos Relief Trust (ART and Kgalagadi Relief Trust, both of which are administered by the ART. This study assessed ARDs and compensation outcomes of environmental claims submitted to the Trusts. Methods: The personal details, medical diagnoses, and exposure information of all environmental claims considered by the Trusts from their inception in 2003 to April 2010 were used to calculate the numbers and proportions of ARDs and compensation awards. Results: There were 146 environmental claimants of whom 35 (23.9% had fibrotic pleural disease, 1 (0.7% had lung cancer, and 77 (52.7% had malignant mesothelioma. 53 (36.3% claimants were compensated: 20 with fibrotic pleural disease and 33 with mesothelioma. Of the 93 (63.7% claimants who were not compensated, 33 had no ARDs, 18 had fibrotic pleural disease, 1 had lung cancer, and 44 had mesothelioma. In addition to having ARDs, those that were compensated had qualifying domestic (33; 62.2% or neighbourhood (20; 37.8% exposures to asbestos. Most of the claimants who were not compensated had ARDs but their exposures did not meet the Trusts’ exposure criteria. Conclusions: This study demonstrates the environmental impact of asbestos mining on the burden of ARDs. Mesothelioma was the most common disease diagnosed, but most cases were not compensated. This highlights that there is little redress for individuals with environmentally acquired ARDs in South Africa. To stop this ARD epidemic, there is a need for the rehabilitation of abandoned asbestos mines and the environment. These issues may not be unique to

  16. Invariance of molecular charge transport upon changes of extended molecule size and several related issues

    Directory of Open Access Journals (Sweden)

    Ioan Bâldea

    2016-03-01

    Full Text Available As a sanity test for the theoretical method employed, studies on (steady-state charge transport through molecular devices usually confine themselves to check whether the method in question satisfies the charge conservation. Another important test of the theory’s correctness is to check that the computed current does not depend on the choice of the central region (also referred to as the “extended molecule”. This work addresses this issue and demonstrates that the relevant transport and transport-related properties are indeed invariant upon changing the size of the extended molecule, when the embedded molecule can be described within a general single-particle picture (namely, a second-quantized Hamiltonian bilinear in the creation and annihilation operators. It is also demonstrates that the invariance of nonequilibrium properties is exhibited by the exact results but not by those computed approximately within ubiquitous wide- and flat-band limits (WBL and FBL, respectively. To exemplify the limitations of the latter, the phenomenon of negative differential resistance (NDR is considered. It is shown that the exactly computed current may exhibit a substantial NDR, while the NDR effect is absent or drastically suppressed within the WBL and FBL approximations. The analysis done in conjunction with the WBLs and FBLs reveals why general studies on nonequilibrium properties require a more elaborate theoretical than studies on linear response properties (e.g., ohmic conductance and thermopower at zero temperature. Furthermore, examples are presented that demonstrate that treating parts of electrodes adjacent to the embedded molecule and the remaining semi-infinite electrodes at different levels of theory (which is exactly what most NEGF-DFT approaches do is a procedure that yields spurious structures in nonlinear ranges of current–voltage curves.

  17. India's nuclear power programme present status, future prospects and related issues

    International Nuclear Information System (INIS)

    Prasad, Y.S.R.

    1998-01-01

    India is poorly placed in terms of world energy resources, while 16% of world's population lives in India, only 6% of coal and 0.6% of oil and gas reserves exist in the country. Moreover, the distribution of primary commercial energy resources is quite skewed. However, India is endowed with vast reserves of thorium. The energy potential of our modest uranium resources and sizeable thorium resources has been estimated to be six times that of our total coal reserves. Though during last fifty years since independence, India has made tremendous progress in the energy sector where the use of commercial energy has increased by ten folds. Electricity used during the same period has increased by eighty times. In spite of such an impressive growth the country, due to population growth, finds itself in the almost lowest bracket with regard to per capita consumption which is many fold lower than the world average. India as of today is a net energy importing country. The demand for energy, in particular electricity that has established to be the most efficient and convenient source, is projected to grow at 7-8% per annum for coming two decades. In such a demand scenario it is imperative that all the resources of energy must be judiciously utilised. However, with the depletion of fossil fuels and resulting possible price shocks a long-term energy security is required for the country. The paper deals with the role nuclear power can play in meeting the country's short term and long term demands, progress made and related issues. (author)

  18. A Qualitative Study of Service Provision for Alcohol Related Health Issues in Mid to Later Life.

    Directory of Open Access Journals (Sweden)

    Catherine Haighton

    Full Text Available Epidemiological surveys over the last 20 years show a steady increase in the amount of alcohol consumed by older age groups. Physiological changes and an increased likelihood of health problems and medication use make older people more likely than younger age groups to suffer negative consequences of alcohol consumption, often at lower levels. However, health services targeting excessive drinking tend to be aimed at younger age groups. The aim of this study was to gain an in-depth understanding of experiences of, and attitudes towards, support for alcohol related health issues in people aged 50 and over.Qualitative interviews (n = 24, 12 male/12 female, ages 51-90 years and focus groups (n = 27, 6 male/21 female, ages 50-95 years were carried out with a purposive sample of participants who consumed alcohol or had been dependent.Participants' alcohol misuse was often covert, isolated and carefully regulated. Participants tended to look first to their General Practitioner for help with alcohol. Detoxification courses had been found effective for dependent participants but only in the short term; rehabilitation facilities were appreciated but seen as difficult to access. Activities, informal groups and drop-in centres were endorsed. It was seen as difficult to secure treatment for alcohol and mental health problems together. Barriers to seeking help included functioning at a high level, concern about losing positive aspects of drinking, perceived stigma, service orientation to younger people, and fatalistic attitudes to help-seeking. Facilitators included concern about risk of fatal illness or pressure from significant people.Primary care professionals need training on improving the detection and treatment of alcohol problems among older people. There is also a compelling need to ensure that aftercare is in place to prevent relapse. Strong preferences were expressed for support to be provided by those who had experienced alcohol problems themselves.

  19. Compensation for environmental asbestos-related diseases in South Africa: a neglected issue.

    Science.gov (United States)

    Ndlovu, Ntombizodwa; Naude, Jim teWater; Murray, Jill

    2013-01-24

    Environmentally acquired asbestos-related diseases (ARDs) are of concern globally. In South Africa, there is widespread contamination of the environment due to historical asbestos mining operations that were poorly regulated. Although the law makes provision for the compensation of occupationally acquired ARDs, compensation for environmentally acquired ARDs is only available through the Asbestos Relief Trust (ART) and Kgalagadi Relief Trust, both of which are administered by the ART. This study assessed ARDs and compensation outcomes of environmental claims submitted to the Trusts. The personal details, medical diagnoses, and exposure information of all environmental claims considered by the Trusts from their inception in 2003 to April 2010 were used to calculate the numbers and proportions of ARDs and compensation awards. There were 146 environmental claimants of whom 35 (23.9%) had fibrotic pleural disease, 1 (0.7%) had lung cancer, and 77 (52.7%) had malignant mesothelioma. 53 (36.3%) claimants were compensated: 20 with fibrotic pleural disease and 33 with mesothelioma. Of the 93 (63.7%) claimants who were not compensated, 33 had no ARDs, 18 had fibrotic pleural disease, 1 had lung cancer, and 44 had mesothelioma. In addition to having ARDs, those that were compensated had qualifying domestic (33; 62.2%) or neighbourhood (20; 37.8%) exposures to asbestos. Most of the claimants who were not compensated had ARDs but their exposures did not meet the Trusts' exposure criteria. This study demonstrates the environmental impact of asbestos mining on the burden of ARDs. Mesothelioma was the most common disease diagnosed, but most cases were not compensated. This highlights that there is little redress for individuals with environmentally acquired ARDs in South Africa. To stop this ARD epidemic, there is a need for the rehabilitation of abandoned asbestos mines and the environment. These issues may not be unique to South Africa as many countries continue to mine and use

  20. Legal issues relating to the use of surrogate mothers in the practice ...

    African Journals Online (AJOL)

    South African Journal of Bioethics and Law. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 5, No 1 (2012) >. Log in or Register to get access to full text downloads.

  1. SOME STATISTICAL ISSUES RELATED TO MULTIPLE LINEAR REGRESSION MODELING OF BEACH BACTERIA CONCENTRATIONS

    Science.gov (United States)

    As a fast and effective technique, the multiple linear regression (MLR) method has been widely used in modeling and prediction of beach bacteria concentrations. Among previous works on this subject, however, several issues were insufficiently or inconsistently addressed. Those is...

  2. Technical findings related to Generic Issue 23: Reactor coolant pump seal failure

    International Nuclear Information System (INIS)

    Ruger, C.J.; Luckas, W.J. Jr.

    1989-03-01

    Reactor coolant pumps contain mechanical seals to limit the leakage of pressurized coolant from the reactor coolant system to the containment. These seals have the potential to leak, and a few have degraded and even failed resulting in a small break loss of coolant accident (LOCA). As a result, ''Reactor Coolant Pump Seal Failure,'' Generic Issue 23 was established. This report summarizes the findings of a technical investigation generated as part of the program to resolve this issue. These technical findings address the various fact-finding issue tasks developed for the action plan associated with the generic issue, namely background information on seal failure, evaluation of seal cooling, and mechanical- and maintenance-induced failure mechanisms. 46 refs., 15 figs., 14 tabs

  3. Biometric Identifiers and Border Security: 9/11 Commission Recommendations and Related Issues

    National Research Council Canada - National Science Library

    Morgan, Daniel; Krouse, William

    2005-01-01

    .... This report provides an overview of biometric technologies and the major U.S. biometric border screening systems, including US-VISIT, and discusses issues such as cost, performance, and user acceptance...

  4. Legal and Ethical Issues Related to the Management of Cultural Heritage in Space

    Science.gov (United States)

    Walsh, Justin

    in space. The United Nations Outer Space Treaty of 1967 -the primary document governing how nations act in outer space -is now hopelessly out-of-date. There is no mention in the treaty of cultural heritage (the UNESCO convention that concerns international protection of cultural heritage on Earth was not completed until 1970), nor was there any recognition of the role private groups and individuals might play in space exploration. This paper will outline key legal and ethical issues related to cultural heritage management and protection. It will also suggest some ways in which culturally significant sites in space can be protected for future study and even touristic appreciation.

  5. Cancer patient perceptions on the ethical and legal issues related to biobanking.

    Science.gov (United States)

    Master, Zubin; Claudio, Jaime O; Rachul, Christen; Wang, Jean C Y; Minden, Mark D; Caulfield, Timothy

    2013-03-08

    Understanding the perception of patients on research ethics issues related to biobanking is important to enrich ethical discourse and help inform policy. We examined the views of leukemia patients undergoing treatment in clinics located in the Princess Margaret Hospital in Toronto, Ontario, Canada. An initial written survey was provided to 100 patients (64.1% response rate) followed by a follow-up survey (62.5% response rate) covering the topics of informed consent, withdrawal, anonymity, incidental findings and the return of results, ownership, and trust. The majority (59.6%) preferred one-time consent, 30.3% desired a tiered consent approach that provides multiple options, and 10.1% preferred re-consent for future research. When asked different questions on re-consent, most (58%) reported that re-consent was a waste of time and money, but 51.7% indicated they would feel respected and involved if asked to re-consent. The majority of patients (62.2%) stated they had a right to withdraw their consent, but many changed their mind in the follow-up survey explaining that they should not have the right to withdraw consent. Nearly all of the patients (98%) desired being informed of incidental health findings and explained that the information was useful. Of these, 67.3% of patients preferred that researchers inform them and their doctors of the results. The majority of patients (62.2%) stated that the research institution owns the samples whereas 19.4% stated that the participants owned their samples. Patients had a great deal of trust in doctors, hospitals and government-funded university researchers, moderate levels of trust for provincial governments and industry-funded university researchers, and low levels of trust towards industry and insurance companies. Many cancer patients surveyed preferred a one-time consent although others desired some form of control. The majority of participants wanted a continuing right to withdraw consent and nearly all wanted to be

  6. Policy issues related to educating the future Israeli medical workforce: an international perspective.

    Science.gov (United States)

    Schoenbaum, Stephen C; Crome, Peter; Curry, Raymond H; Gershon, Elliot S; Glick, Shimon M; Katz, David R; Paltiel, Ora; Shapiro, Jo

    2015-01-01

    A 2014 external review of medical schools in Israel identified several issues of importance to the nation's health. This paper focuses on three inter-related policy-relevant topics: planning the physician and healthcare workforce to meet the needs of Israel's population in the 21(st) century; enhancing the coordination and efficiency of medical education across the continuum of education and training; and the financing of medical education. All three involve both education and health care delivery. The physician workforce is aging and will need to be replenished. Several physician specialties have been in short supply, and some are being addressed through incentive programs. Israel's needs for primary care clinicians are increasing due to growth and aging of the population and to the increasing prevalence of chronic conditions at all ages. Attention to the structure and content of both undergraduate and graduate medical education and to aligning incentives will be required to address current and projected workforce shortage areas. Effective workforce planning depends upon data that can inform the development of appropriate policies and on recognition of the time lag between developing such policies and seeing the results of their implementation. The preclinical and clinical phases of Israeli undergraduate medical education (medical school), the mandatory rotating internship (stáge), and graduate medical education (residency) are conducted as separate "silos" and not well coordinated. The content of basic science education should be relevant to clinical medicine and research. It should stimulate inquiry, scholarship, and lifelong learning. Clinical exposures should begin early and be as hands-on as possible. Medical students and residents should acquire specific competencies. With an increasing shift of medical care from hospitals to ambulatory settings, development of ambulatory teachers and learning environments is increasingly important. Objectives such as these

  7. Proliferation prevention in the commercial fuel cycle

    International Nuclear Information System (INIS)

    Sutcliffe, W.G.

    1999-01-01

    This website contains the papers presented on November 17, 1998 during the session, ''Proliferation Prevention in the Commercial Fuel Cycle,'' at the American Nuclear Society meeting in Washington, DC. The abstracts are in a separate section; individual papers also contain the author's bio and e-mail address. In the session planning phase, it was suggested that the following questions and other relevant issues be addressed: * What are the difficulties and issues with defining and enforcing international standards for the physical protection of Pu and HEU (beyond the Convention on the Physical protection of Nuclear Material, which primarily addresses transportation)? * How do we (or can we) keep nuclear technology in general, and reprocessing and enrichment technologies in particular, from spreading to undesirable organizations (including governments), in light of Article IV of the NPT? Specifically, can we (should we) prevent the construction of light-water reactors in Iran; and should we support the construction of light-water reactors in North Korea? * Are there more proliferation-resistant fuel cycles that would be appropriate in developing countries? * Can the concept of ''nonproliferation credentials'' be defined in a useful way? * Is there historical evidence to indicate that reprocessing (or enrichment of HEU) in the US, Japan, or the EURATOM countries has impacted the acquisition (or attempted acquisition) of nuclear weapons by other nations or groups? * What is the impact of a fissile material cutoff treaty (FMCT) be on commercial nuclear fuel cycles? * Does MOX spent fuel present a greater proliferation risk than LEU spent fuel? Although the authors did not explicitly attempt to answer all these questions, they did enlighten us about a number of these and related issues

  8. Theoretical Approaches to Nuclear Proliferation

    Directory of Open Access Journals (Sweden)

    Konstantin S. Tarasov

    2015-01-01

    Full Text Available This article analyses discussions between representatives of three schools in the theory of international relations - realism, liberalism and constructivism - on the driving factors of nuclear proliferation. The paper examines major theoretical approaches, outlined in the studies of Russian and foreign scientists, to the causes of nuclear weapons development, while unveiling their advantages and limitations. Much of the article has been devoted to alternative approaches, particularly, the role of mathematical modeling in assessing proliferation risks. The analysis also reveals a variety of different approaches to nuclear weapons acquisition, as well as the absence of a comprehensive proliferation theory. Based on the research results the study uncovers major factors both favoring and impeding nuclear proliferation. The author shows that the lack of consensus between realists, liberals and constructivists on the nature of proliferation led a number of scientists to an attempt to explain nuclear rationale by drawing from the insights of more than one school in the theory of IR. Detailed study of the proliferation puzzle contributes to a greater understating of contemporary international realities, helps to identify mechanisms that are most likely to deter states from obtaining nuclear weapons and is of the outmost importance in predicting short- and long-term security environment. Furthermore, analysis of the existing scientific literature on nuclear proliferation helps to determine future research agenda of the subject at hand.

  9. Some issues related to the development of nuclear power plant in Indonesia

    International Nuclear Information System (INIS)

    Panggabean, L.M.

    1987-01-01

    Indonesia being a member of ASEAN belongs to the group of developing country. If Indonesia decides to embark on the establishment of nuclear power plan then the country will have no choice but to discuss the following issues: Safe operation of the plant and management of the nuclear waste. Safe operation of the power plant is important not only from the point of view of hazards to human being, or economic loss, or even death, but equally important it is also from the psychological point of view in that not to loose the society's confidence in the overall nuclear power plant programme in the future. The issue of safe operation involves both a safely designed system as well as skilled personnels to execute a well designed operation procedure. The issue of nuclear safety is getting more and more attention lately for various, some due to a deep concern about the quality of the inherent safety of the nuclear power plant to be built, others may just use their emotion to ask question like ''what its''. The issue of nuclear waste is as fundamental as the plant safety. Common people make very little difference between an atomic bomb and waste from a nuclear power plant. Another issue is one of transfer of technology which needs to be tied up with the overall industrialization process, meaning that embarking on nuclear power programme needs to contribute to local industrial activities, at least for some parts or components which can be manufactured locally. (author)

  10. Stakeholders' perspective on issues and challenges associated with care and treatment of aging-related cognitive impairment disorders in Singapore.

    Science.gov (United States)

    Setia, Monika; Islam, Amina M; Thompson, James P; Matchar, David B

    2011-11-01

    An expanding elderly population poses challenges for the provision of care and treatment for age-related physical and mental disorders. Cognitive impairment (CI)/dementia is one such mental disorder that is on the rise in Singapore and has concomitant implications for social and health systems. The objective of this study is to understand the perspectives of prominent stakeholders about current and future issues and challenges associated with CI/dementia among the elderly in Singapore. Using indepth interviews, this qualitative study obtained the views of multiple stakeholders on issues and challenges associated with CI/dementia in Singapore. The 30 individuals interviewed as part of the study included clinicians, policy-makers, researchers, community workers, administrators, and caregivers. Using a framework approach, interview texts were indexed into domains and issues by utilizing NVivo 9.0 software. The stakeholders expressed concerns related to multiple domains of the CI/dementia care system: attitude and awareness, economics, education, family caregiving, inputs to care system, living arrangements, prevention, screening and diagnosis, and treatment and management of care. Within each domain, multiple issues and challenges were identified by respondents. The study identifies a complex set of inter-related issues and challenges that are associated with the care and treatment of people with CI/dementia. The results suggest that CI and dementia profoundly affect patients, families, and communities and that the issues related to the two disorders are truly system-wide. These findings lay the foundation for utilization of a systems approach to studying CI/dementia and provide an analytic framework for future research on complex health care issues.

  11. Elements of safety and non proliferation

    International Nuclear Information System (INIS)

    Jalouneix, Jean; Aurelle, Jacques; Funk, Pierre; Ladsous, David; Bon Nguyen, Romuald; Goue, Georges; Lefevre, Odile

    2015-01-01

    This book on nuclear safety and non proliferation is based on knowledge and expertise of the IRSN. The first chapter addresses the safety of nuclear materials, of their installations and of their transportations. It proposes some contextual elements, presents the general guidelines of the French nuclear safety arrangement, the approach to take risks into account, the involved governmental and public bodies, the legal framework, and the protection and control arrangement (in terms of planning of safety-related activities, in terms of operator obligations, in terms of exercises and management crisis). The second part addresses the safety of radioactive sources: context (peculiarity, losses and thefts), international framework (source categories, Euratom directive), and the French organisation. The third chapter addresses nuclear non proliferation: historical background (creation and role of the IAEA and of the EAEC, definitions), principle of statements, inspection process, and French organisation (legal framework, governmental bodies, the IRSN). The last chapter addresses the issue of chemical non proliferation: historical background, international context (Convention on chemical weapons, organisation for their ban), and the French organisation

  12. Non-proliferation policies and demand for uranium

    International Nuclear Information System (INIS)

    Warnecke, S.J.

    1978-01-01

    The non-proliferation policies of USA, Canada and Australia are outlined, and the effects on nuclear policy in the consumer countries, particularly the member states of the European Community and Japan are considered. Supply and demand in relation to uranium, security and economic aspects are covered. Reprocessing, the use of plutonium in breeder reactors, and the wider issues of international confidence and trade are discussed. (U.K.)

  13. Separation of nuclear power from nuclear proliferation

    International Nuclear Information System (INIS)

    Starr, C.

    1978-01-01

    A successful development of the proposed combination of the Fast Breeder Reactor and the CIVEX fuel reprocessing facility would provide an economical nuclear power source for many centuries which inherently separates nuclear power from the issue of weapons material diversion and proliferation. Further, by so doing, it permits great flexibility in international and national planning for nuclear power, as the issues of fuel dependence and terrorist and subnational diversions disappear. In addition, the expansion of the FBR/CIVEX system would eat into the LWR spent fuel stockpile, diminishing steadily this relatively accessible plutonium source. And finally, a rapid development of the FBR/CIVEX for the above reasons would substantially reduce the worldwide concern as to the adequacy of uranium ore supply. From a historical view, it would restore fast reactor development to the path originally foreseen in the programs of worldwide nuclear energy authorities, including the Atomic Energy Commission during its first two decades of existence

  14. Issues related to the USEPA probabilistic standard for geologic disposal of high-level radioactive waste

    International Nuclear Information System (INIS)

    Okrent, D.

    1993-01-01

    This paper asks whether some of the fundamental bases for the 1985 USEPA standard on disposal of high level radioactive wastes (40 CFR Part 191) warrant re-examination. Similar questions also apply to the bases for the radioactive waste disposal requirements proposed by most other countries. It is suggested that the issue of intergenerational equity has been dealt with from too narrow a perspective. Not only should radioactive and nonradioactive hazardous waste disposal be regulated from a consistent philosophic basis, but the regulation of waste disposal itself should be embedded in the broader issues of intergenerational conservation of options, conservation of quality, and conservation of access. (author). 25 refs

  15. Discussion of some issues in assessing nuclear and radiation environmental impacts and in related assessment

    International Nuclear Information System (INIS)

    Pan Ziqiang

    1998-01-01

    The author discusses some noticeable issues in drafting assessment report of nuclear and radiation environmental impacts and relevant aspects needed to be considered from the point of view of comprehensive environmental assessment. The considerable issue are principles of radioactive waste management, optimization of radiation protection and collective dose, and uncertainty of the assessment. Implementing reporting system on assessment of nuclear and radiation environmental impacts would improve environmental protection for nuclear and radiation facilities. However, trade's, regional , country and global assessment of environmental impacts has to be enhanced. For this purpose, it is necessary to develop methodology of qualitative and quantitative comprehensive assessment

  16. Brexit, Euratom and nuclear proliferation

    International Nuclear Information System (INIS)

    Soedersten, Anna

    2016-01-01

    One of the issues absent from the academic (and public) debate on the United Kingdom's (UK) referendum vote to withdraw from the European Union (EU) (commonly referred to as 'Brexit') is what will happen to the UK's membership in the European Atomic Energy Community (Euratom). The Euratom Treaty was signed in Rome in 1957, together with the European Economic Community (EEC) Treaty. It was concluded for an unlimited period and it establishes a Community that has a separate legal personality from the EU. Thus, the EU and Euratom form two separate, although closely linked entities. Euratom's principal mission is related to the economy, tasked with 'creating the conditions necessary for the speedy establishment and growth of nuclear industries'; in other words, to promote the nuclear industry. This reflects the high expectations for nuclear energy in the 1950's. Some even believed that the development of nuclear energy would trigger an industrial revolution; however, Euratom only came to play a minor role in the European integration process. Despite this, the Euratom Treaty has remained, almost unchanged, since its adoption and is still frequently applied, although it is unclear to what extent it has boosted the nuclear industry. This article has a two-fold purpose. The first purpose is to address the constitutional issue of 'partial membership'. All EU member states are also members of Euratom. It has always been assumed that with membership in the EU also comes a membership in Euratom. But, what about withdrawal? What are the arguments for 'partial membership'? The second purpose of this article is to shed light on some implications of Brexit as it relates to Euratom. The most serious consequences are perhaps found in the area of nuclear non-proliferation. The United Kingdom is one of two nuclear weapon states in the EU (France being the other one). Withdrawal from Euratom means withdrawal from its control system, the system of so-called nuclear safeguards. Under

  17. Surveillance of social and geographic inequalities in housing-related issues: the case of the Eastern Townships, Quebec (Canada).

    Science.gov (United States)

    Roy, Mathieu; Généreux, Mélissa; Laverdière, Emélie; Vanasse, Alain

    2014-05-06

    Even though health inequalities are conditioned by many aspects of the environment, much of the existing research focuses on the social environment. This emphasis has the effect to neglect other environmental aspects such as its physical dimension. The physical environment, which is linked to housing conditions, may contribute to the uneven distribution of health. In this study, we examined 19 housing-related issues among a representative sample of 2,000 adults residing in a Quebec (Canada) health region characterized by a mix of rural, semi-rural, and urban areas. The distribution of these issues was examined according to socioeconomic and geographic indicators of social position. Summary measures of inequalities were assessed. Our results showed that the prevalence of nearly all housing-related issues was higher among low-income households compared to more affluent ones. Highly educated individuals showed better housing conditions, whereas different issues tended to cluster in deprived or densely populated areas. To conclude, we observed steep gradients between social class and poor housing conditions. This may explain a substantial part of health inequality on the regional scale. The surveillance of housing-related issues is therefore essential to properly inform and mobilize local stakeholders and to develop interventions that target vulnerable groups on this level.

  18. The USA and proliferation in Northeast Asia

    International Nuclear Information System (INIS)

    Weeks, S.B.

    1995-01-01

    United States policy on proliferation in Northeast Asia poses a test of balance between general US global non-proliferation goals and specific US regional security goals for Northeast Asia. US policy on proliferation in Northeast Asia further poses a test of priorities for US bilateral relations with the key Northeast Asian states, as non-proliferation and regional security goals must be weighed against other (e.g., economic, human rights) declared US policy goals. The result is a US policy equation for Northeast Asia proliferation that is considerably more complex in execution than might be expected from the simple statement of the US goal to avoid nuclear proliferation in Northeast Asia. The question of security assurances - both negative and positive - may be closely related to US policies to avoid proliferation in Northeast Asia

  19. Ethical Issues Relative to Autonomy and Personal Control in Independent and Cognitively Impaired Elders.

    Science.gov (United States)

    Rice, Virginia Hill; And Others

    1997-01-01

    Discusses ethical issues surrounding health care for independent elders, those in long-term care, and those with cognitive impairments, as well as death, dying, euthanasia, and assisted suicide. Suggests that nurses should focus on older adults' choice, autonomy, and personal control. (SK)

  20. Forces and Issues Related to Curriculum and Instruction, 7-12

    Science.gov (United States)

    Osborne, Alan R.; Crosswhite, F. Joe

    1970-01-01

    This unit is divided into three chapters concerned with Emerging Issues: 1890-1920," Mathematics Education on the Defensive: 1920-45," and Reform, Revolution, and Reaction." Of particular interest are discussions of the aims and impact of the Report of the Committee of Ten," The 1923 Report" and the Cambridge Report.…

  1. Secondary School Students' Interests, Attitudes and Values Concerning School Science Related to Environmental Issues in Finland

    Science.gov (United States)

    Uitto, Anna; Juuti, Kalle; Lavonen, Jari; Byman, Reijo; Meisalo, Veijo

    2011-01-01

    This paper explores the relationship between students' interests in environmental issues, attitudes to environmental responsibility and biocentric values in school science education. The factors were investigated within the framework of three moderators: gender, school and residential area of the school. The survey was carried out using the…

  2. Turkish Preservice Teachers' Perceptions of Children's Picture Books Reflecting LGBT-Related Issues

    Science.gov (United States)

    Dedeoglu, Hakan; Ulusoy, Mustafa; Lamme, Linda L.

    2012-01-01

    This research study focuses on Turkish preservice teachers' perceptions of children's picture books containing lesbian, gay, bisexual, and transgender issues to lend support to encouraging diversity in teacher education programs and elementary school classrooms. The authors proposed that reading, listening, and responding to diverse children's…

  3. Teachers' Controversial Issue Decisions Related to Race, Gender, and Religion during the 2008 Presidential Election

    Science.gov (United States)

    Journell, Wayne

    2011-01-01

    Using the 2008 Presidential Election as a case of curricular controversy, the author describes how six high school government teachers responded to the racial, gender, and religious diversity included on the presidential tickets of the two major political parties. Teachers had to decide whether the issue of Americans challenging the tradition of…

  4. The Asilomar Survey: Stakeholders' Opinions on Ethical Issues Related to Brain-Computer Interfacing

    NARCIS (Netherlands)

    Nijboer, Femke; Clausen, Jens; Allison, Brendan Z.; Haselager, Pim

    2013-01-01

    Brain-Computer Interface (BCI) research and (future) applications raise important ethical issues that need to be addressed to promote societal acceptance and adequate policies. Here we report on a survey we conducted among 145 BCI researchers at the 4th International BCI conference, which took place

  5. The Asilomar Survey: Stakeholders’ Opinions on Ethical Issues Related to Brain-Computer Interfacing

    NARCIS (Netherlands)

    Nijboer, F.; Clausen, J.; Allison, B.Z.; Haselager, W.F.G.

    2013-01-01

    Brain-Computer Interface (BCI) research and (future) applications raise important ethical issues that need to be addressed to promote societal acceptance and adequate policies. Here we report on a survey we conducted among 145 BCI researchers at the 4th International BCI conference, which took place

  6. An Exploration of School Leadership Issues Relating to the "December Dilemma"

    Science.gov (United States)

    Fox, Anna L.; Vasek, Austin; Davis, Derek

    2012-01-01

    School leadership is required to navigate difficult issues concerning the religious liberties of their students. December is a month filled with secular and religious holidays. It is the one month on the school calendar filled with joyous cultural celebrations. However, it can also become a quandary for leadership when attempting to balance the…

  7. The issue of energy security in relations between the European Union and Azerbaijan

    Directory of Open Access Journals (Sweden)

    O V Shabelnikova

    2014-12-01

    Full Text Available The article focuses on cooperation between the European Union and the Republic of Azerbaijan on energy issues. The author analyzes the EU initiatives and projects for the Black Sea and Caspian Sea region as well as the questions of delivery diversification of the Azerbaijani gas to the European markets.

  8. The Press Relations of a Local School District: An Analysis of the Emergence of School Issues.

    Science.gov (United States)

    Morris, Jon R.; Guenter, Cornelius

    Press coverage of a suburban midwest school district is analyzed as a set of time series of observations including the amount and quality of coverage. Possible shifts in these series because of the emergence of controversial issues are analyzed statistically using the Integrated Moving Average Time Series Model. Evidence of significant shifts in…

  9. 76 FR 22340 - Further Inquiry Into Tribal Issues Relating to Establishment of a Mobility Fund

    Science.gov (United States)

    2011-04-21

    ... INFORMATION CONTACT: Wireless Telecommunications Bureau, Auctions and Spectrum Access Division: Scott Mackoul... comment on those proposals. What issues should receive priority in a flow of information and exchange of... are pending proposals regarding utilization of spectrum over Tribal lands that could benefit from the...

  10. Education of the handicapped child: Status, trend, and issues related to electronic delivery

    Science.gov (United States)

    Rothenberg, D.

    1973-01-01

    This study is part of a broader investigation of the role of large-scale educational telecommunications systems. Thus, data are analyzed and trends and issues discussed to provide information useful to the systems designer who wishes to identify and assess the opportunities for large-scale electronic delivery of education for the handicapped.

  11. Panax ginseng total protein promotes proliferation and secretion of collagen in NIH/3T3 cells by activating extracellular signal-related kinase pathway

    Directory of Open Access Journals (Sweden)

    Xuenan Chen

    2017-07-01

    Conclusion: Our studies suggest that GTP promoted proliferation and secretion of collagen in NIH/3T3 cells by activating the ERK signal pathway, which shed light on a potential function of GTP in promoting wound healing.

  12. Variation in the peroxisome proliferator-activated receptor δ gene in relation to common metabolic traits in 7,495 middle-aged white people

    DEFF Research Database (Denmark)

    Grarup, Niels; Albrechtsen, A.; Ek, J.

    2007-01-01

    Studies in animals reveal that peroxisome proliferator-activated receptor delta (PPARdelta) regulates glucose metabolism and insulin sensitivity in both the liver and skeletal muscles. Moreover, PPARdelta augments physical endurance and increases oxidative metabolism, thereby averting obesity. Th...

  13. Technical features to enhance proliferation resistance of nuclear energy systems

    International Nuclear Information System (INIS)

    2010-01-01

    It is generally accepted that proliferation resistance is an essential issue for the continued development and sustainability of nuclear energy. Several comprehensive assessment activities on the proliferation resistance of the nuclear fuel cycle have previously been completed, notably the International Nuclear Fuel Cycle Evaluation (INFCE) carried out under the auspices of the IAEA, and the Non-proliferation Alternative Systems Assessment Program (NASAP) review carried out by the USA. There have been, however, relatively few comprehensive treatments of the issue following these efforts in the 1970s. However, interest in and concern about this issue have increased recently, particularly because of greater interest in innovative nuclear fuel cycles and systems. In 2000, the IAEA initiated the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) and the US Department of Energy initiated the Generation IV International Forum (GIF). These projects are aimed at the selection and development of concepts of innovative nuclear energy systems and fuel cycles. Proliferation resistance is one of the fundamental considerations for both projects. In this context, the IAEA in 2001 initiated a study entitled 'Technical Aspects of Increasing Proliferation Resistance of the Nuclear Fuel Cycle'. This task is not intended as an effort to assess the merits of a particular fuel cycle system for the future, but to describe a qualitative framework for an examination of the proliferation resistance provided by the intrinsic features of an innovative nuclear energy system and fuel cycle. This task also seeks to provide a high level survey of a variety of innovative nuclear energy systems and fuel cycles with respect to that framework. The concept of proliferation resistance is considered in terms of intrinsic features and extrinsic measures. The intrinsic features, sometimes referred to as the physical/technical aspects, are those features that result from the

  14. Initial attachment, subsequent cell proliferation/viability and gene expression of epithelial cells related to attachment and wound healing in response to different titanium surfaces.

    Science.gov (United States)

    An, Na; Rausch-fan, Xiaohui; Wieland, Marco; Matejka, Michael; Andrukhov, Oleh; Schedle, Andreas

    2012-12-01

    A tight seal between the epithelium and the dental implant surface is required to prevent bacterial inflammation and soft tissue recession and therefore to demonstrate a long-term success. Surface hydrophilicity was recently shown to promote osseointegration. The aim of this study was to investigate the influence of surface hydrophilicity in combination with surface topography of Ti implant surfaces on the behavior and activation/differentiation of epithelial cells using a set of in vitro experiments mimicking the implant-soft tissue contact. Hydrophobic acid-etched (A) and coarse-grit-blasted, acid-etched (SLA) surfaces and hydrophilic acid-etched (modA) and modSLA surfaces were produced. The behavior of an oral squamous cell carcinoma cell line (HSC-2) grown on all surfaces was compared through determination of cell attachment and proliferation/viability (CCK-8 and MTT assay), time-lapse microscopy of fluorescence labeled cells and determination of gene expression by real time polymerase chain reaction. Within the surfaces with similar wettability cell spreading and cell movements observed by time-lapse microscopy after one day of incubation were most pronounced on smoother (A and modA) surfaces compared to rougher (SLA and modSLA) surfaces. Within the surfaces with similar roughness the hydrophilic surfaces (modA and modSLA) showed more cell spreading and cell activity compared to the hydrophobic surfaces (A and SLA). The relative gene expressions of cytokeratin14, integrin α6, integrin β4, vinculin, transforming growth factor (TGF)-β, TGF-β1, and TGF-β3 were decreased in HSC-2 on all four types of Ti surfaces compared to control surfaces (tissue culture polystyrene; pmodA). These results suggest that surface hydrophilicity might positively influence the epithelial seal around dental implants. All tested titanium surfaces downregulate cell attachment, cell proliferation, expression of adhesion promoters, and cytokines involved in wound healing in HSC-2

  15. Modernism and Postmodernism: A Study of the Islamic Teachings with Special Reference to the Related Issues of Pakistani Society

    Directory of Open Access Journals (Sweden)

    Dr. Abdul Muhaimin

    2017-02-01

    Full Text Available Abstract This study elaborates the difference and connection between modernism and postmodernism eras while highlighting their backgrounds. The research highlights the teachings of Islam in terms of modernism and postmodernism. The research brings to light the influence of modernism and postmodernism on Muslim societies. What are the far reaching impacts of the modernism and postmodernism eras of Muslim societies and how well a common Muslim is equipped to address the issues related to postmodernism. The study primarily focuses on the related issues in Pakistani society and explains the role and the influence of religious scholars of their understanding of the terms modernism and postmodernism. The study focuses on the awareness of the ’Ulamā in addressing these global challenges and subsequently the future of Pakistani society. The study has an element of quantitative research and it indicates towards the on ground realities on the issue with the help of a latest survey on modernism and postmodernism.

  16. Factors Affecting Recruitment and Attrition in Randomised Controlled Trials of Complementary and Alternative Medicine for Pregnancy-Related Issues

    Directory of Open Access Journals (Sweden)

    Ciara Close

    2016-01-01

    Full Text Available Background. Randomised controlled trials (RCTs investigating Complementary and Alternative Medicine (CAM for pregnancy-related issues have encountered issues with recruitment and attrition. Little is known about the cause of these issues. Methods. Data was gathered from an antenatal CAM randomised controlled trial. During foetal anomaly appointments, women meeting inclusion criteria were invited to participate in the trial. Numbers of women invited and eligible were recorded. Reasons for noninterest were noted and analysed. Focus groups exploring trial experience of participants were also conducted. Findings. Of the 428 women invited to participate, 376 were eligible and just under a quarter participated. Reasons for nonparticipation included concerns about CAM and lack of interest in participation in research. Other factors negatively affecting recruitment included recruitment timing, competition for participants, limited support from staff, and inadequate trial promotion. Factors encouraging recruitment included being interested in research and seeking pain relief. Reasons for dropping out were time constraints, travel issues, work commitments, and pregnancy issues. Several women in the sham and usual care group dropped out due to dissatisfaction with treatment allocation. Conclusion. CAM researchers must explore problems encountered with recruitment and attrition so that evidence-based implementation strategies to address the issues can be developed.

  17. SPECIAL ISSUE OF THE JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION ON THE PARTICULATE MATTER SUPERSITES PROGRAM AND RELATED STUDIES

    Science.gov (United States)

    This article is the preface or editors note to the dedicated issue of the Journal of the Air & Waste Management Association for a selection of scientific papers from the specialty conference entitled, "Particulate Matter Supersites Program and Related Studies," that was...

  18. EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (Volume 1) (Interagency Science Discussion Draft)

    Science.gov (United States)

    EPA is releasing the draft report, EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (Volume 1), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the Review of spent fuel related issues in SKB's SR 97

    Energy Technology Data Exchange (ETDEWEB)

    Grambow, B. [Ecole des Mines de Nantes (France). SUBATECH-Laboratory

    2000-12-01

    The solid waste form 'spent fuel' constitutes both the dominant radionuclide source as well as a first radionuclide retention barrier of a planned future high level nuclear waste isolation systems in deep granite formations. In order to evaluate the performance of spent fuel as part of the multibarrier containment system in a deep repository, the radionuclide release properties in groundwater must be predicted over very long time periods. Radionuclide release is not an inherent materials property of the fuel but depends, besides fuel specific parameters, mainly on time but as well on the geochemical and hydraulic environment of the disposal location. The study SR 97 documents the large effort of SKB to assess the long-term performance of a repository containing spent nuclear fuel. Scenario and consequence analyses are clearly described, considering major physical and chemical interactions of the various components of the multi-barrier isolation system. The approach attempts to assess both a realistic and a pessimistic evolution scenario. The present report attempts to evaluate whether this approach is thoroughly carried through to assess the performance of spent nuclear fuel in a repository. Main issues are radionuclide inventories and inventory distribution between structural parts of the fuel assembly and the fuel matrix, potential fuel alteration prior to water access, as well as models for fuel matrix dissolution and instant release fractions. Uncertainties in radionuclide inventories are discussed and were found for many radionuclides to be higher than assumed in SR 97. This is particularly true for Cl-36. This nuclide is a potential key biosphere dose contributor in various international safety assessments. Of particular importance are uncertainties related to the partition of radionuclides between metallic parts of the fuel assembly and the fuel matrix, since inventories of metallic parts are considered to be released instantaneously. Using C-14 as

  19. The Vilnius issue in international relations: the historiography of the problem

    Directory of Open Access Journals (Sweden)

    Mankevich Maria

    2012-03-01

    Full Text Available This article considers certain historiographical aspects of the Vilnius issue as an international problem. The author analyses the origins of the Polish-Lithuanian conflict, the role of the struggle for Vilnius in the general context of the Polish-Lithuanian confrontation, and the origin and nature of Lithuanian nationalism. The article also examines historiographical perspectives on the seizure of Vilnius by the troops of the Polish general, L. Żeligowsky, and the international consequences of the violation of the Suwałki Agreement. The author pays special attention to the positions of western powers, the decision of the Conference of Ambassadors on March 15, 1923, and the mediation of the League of Nations in the territorial dispute between Lithuania and Poland. The article considers the existing historiographical concepts and evaluations of the role of the Soviet diplomacy in the Vilnius issue. The author identifies new trends in the contemporary historiography of the Vilnius problem.

  1. The effect of plant aging on equipment qualification and human performance issues related to license renewal

    International Nuclear Information System (INIS)

    Gunther, W.E.; Higgins, J.C.; Aggarwal, S.K.

    1991-01-01

    The aging of nuclear power plants is one of the most important issues facing the nuclear industry worldwide. Aging encompasses as forms of degradation to nuclear power plant components, systems, and structures that result from exposure to environmental conditions or from operational stresses. Both the degradation from aging and actions taken to address the aging, such as increased maintenance and testing, can significantly impact human performance in the plant. Research into the causes and effects of aging as obtained through the assessment of operating experience and testing have raised questions regarding the adequacy of existing industry standards for addressing the concerns raised by this research. This paper discusses these issues, with particular emphasis in the area of equipment qualification and human performance

  2. The effect of plant aging on equipment qualification and human performance issues related to license renewal

    Energy Technology Data Exchange (ETDEWEB)

    Gunther, W.E.; Higgins, J.C. [Brookhaven National Lab., Upton, NY (United States); Aggarwal, S.K. [Nuclear Regulatory Commission, Washington, DC (United States)

    1991-12-31

    The aging of nuclear power plants is one of the most important issues facing the nuclear industry worldwide. Aging encompasses as forms of degradation to nuclear power plant components, systems, and structures that result from exposure to environmental conditions or from operational stresses. Both the degradation from aging and actions taken to address the aging, such as increased maintenance and testing, can significantly impact human performance in the plant. Research into the causes and effects of aging as obtained through the assessment of operating experience and testing have raised questions regarding the adequacy of existing industry standards for addressing the concerns raised by this research. This paper discusses these issues, with particular emphasis in the area of equipment qualification and human performance.

  3. The effect of plant aging on equipment qualification and human performance issues related to license renewal

    Energy Technology Data Exchange (ETDEWEB)

    Gunther, W.E.; Higgins, J.C. (Brookhaven National Lab., Upton, NY (United States)); Aggarwal, S.K. (Nuclear Regulatory Commission, Washington, DC (United States))

    1991-01-01

    The aging of nuclear power plants is one of the most important issues facing the nuclear industry worldwide. Aging encompasses as forms of degradation to nuclear power plant components, systems, and structures that result from exposure to environmental conditions or from operational stresses. Both the degradation from aging and actions taken to address the aging, such as increased maintenance and testing, can significantly impact human performance in the plant. Research into the causes and effects of aging as obtained through the assessment of operating experience and testing have raised questions regarding the adequacy of existing industry standards for addressing the concerns raised by this research. This paper discusses these issues, with particular emphasis in the area of equipment qualification and human performance.

  4. Technical issues related to NUREG 0800, Chapter 18: Human Factors Engineering/Standard Review Plan

    International Nuclear Information System (INIS)

    Savage, J.W.

    1982-01-01

    The revision of Chapter 18 of NUREG 0800, Human Factors Engineering Standard Review Plan (SRP) will be based on SECY 82-111 and guidance contained in NUREG 0700, NUREG 0801 and NUREG 0835, plus other references. In conducting field reviews of control rooms, the NRC has identified technical issues which can be used to enhance the development of the revised version of NUREG 0800, and to establish priorities among the list of possible Branch Technical Positions (BTP) in NUREG 0800, Rev. 0, Table 18.0-2. This report is a compilation of comments and suggestions from the people who used NUREG 0700 in the Control Room field reviews. This information was used to establish possible BTP topic priorities so that the most important BTPs could be issued first. The comments and suggestions are included for HFEB review in conjunction with the table of priorities

  5. Anticipating issues related to increasing preimplantation genetic diagnosis use: a research agenda.

    Science.gov (United States)

    Klitzman, Robert; Appelbaum, Paul S; Chung, Wendy; Sauer, Mark

    2008-01-01

    Increasing use of preimplantation genetic diagnosis (PGD) poses numerous clinical, social, psychological, ethical, legal and policy dilemmas, many of which have received little attention. Patients and providers are now considering and using PGD for a widening array of genetic disorders, and patients may increasingly seek 'designer babies.' In the USA, although governmental oversight policies have been discussed, few specific guidelines exist. Hence, increasingly, patients and providers will face challenging ethical and policy questions of when and for whom to use PGD, and how it should be financed. These issues should be better clarified and addressed through collection of data concerning the current use of PGD in the USA, including factors involved in decision making about PGD use, as well as the education of the various communities that are, and should be, involved in its implementation. Improved understanding of these issues will ultimately enhance the development and implementation of future clinical guidelines and policies.

  6. How would we deal with radiation related issues in high school educational programs?

    International Nuclear Information System (INIS)

    Saeki, Kuniko

    1999-01-01

    Current educational curriculum will be more improved and the materials in schools will be somewhat different by the year of 2002 when students have two days off in a week. It is a well known fact that recent Japanese people's level of understanding about Science and Technology is the second from the bottom among OECD nations and, as a matter of fact, few schools are dealing with scientific issues such as atomic energy or radiation. High school teachers need to survey what students know about atomic power and radiation, how deep they studied in previous schools and what kind of interest they have in conservation of world energy sources or environmental issues discussed today. Through questionnaires to 328 students, it became clear that they were most interesting to the effect of radiation or radioactivity on any kind of things in the environment, and that they want to know solutions for those problems such as greenhouse effect, ozone layers and Garbage disposal. (M. Suetake)

  7. Work-Related Issues Facing Nurse Anesthetists During Deployment on a Military Operation Other Than War

    Science.gov (United States)

    2000-10-01

    transferability ( Denzin & Lincoln , 1994; Morse & Field, 1995; Wilson, 1993). Denzin and Lincoln (1994) note that in qualitative research, the terms credibility...DEPLOYMENT ISSUES 56 Denzin , N.K., & Lincoln ,Y.S. (Eds.)(1994). Handbook of qualitative research. (pp. 1-17). Thousand Oaks, CA: Sage. Department of the...Association of Operating Room Nurses, 62, 875-883. Strauss, A., Corbin, J. (1994). Grounded theory methodology. In Denzin , N.K., & Lincoln , Y.S

  8. U.S.-Vietnam Relations in 2011: Current Issues and Implications for U.S. Policy

    Science.gov (United States)

    2012-05-18

    a policy of neutrality on the claims by the parties, which also include Brunei, Indonesia, Malaysia , the Philippines, and Taiwan. Throughout 2009...territorial disputes. Roughly one and a half times the size of the Mediterranean Sea, it is ringed by China, Vietnam, Malaysia , Indonesia, Brunei...government to monitor data processed by these companies and/or more susceptible to government pressure on issues such as censorship .36 Many of the

  9. OPINION OF YOUTH ON ISSUES AND CHALLENGES RELATED TO EMPLOYMENT: A STUDY IN MYSORE CITY

    OpenAIRE

    Dr. Mohan A.K

    2017-01-01

    Employment status is one of the developmental indicators of nation. For this two things are vital, one is availability of employment opportunities and second is skillful workforce. Employment and skills are linked with many other social, economic and demographic factors. India is hoping to excel economically using its youth power. Hence many skill development programmes linked with employment options are being provided to youth by government and non-government agencies. However, the issue of ...

  10. Agri-food supply chains and sustainability-related issues: evidence from across the Scottish agri-food economy

    OpenAIRE

    Leat, Philip M.K.; Lamprinopoulou-Kranis, Chrysa; Revoredo-Giha, Cesar; Kupiec-Teahan, Beata

    2011-01-01

    This paper examines the influence of agri-food supply chains on the sustainability-related activities and decisions of Scottish farmers, as well as the treatment of sustainability issues by food processors and retailers themselves. It is based on 8 whole chain case studies covering some of Scotland’s major agricultural products. The cases identify differing levels of understanding and activities related to sustainability, but widespread acknowledgement that sustainability involves the develop...

  11. Analysis of Environmental Issues Related to Small-Scale Hydroelectric Development IV: Fish Mortality Resulting From Turbine Passage

    Energy Technology Data Exchange (ETDEWEB)

    Turbak, Susan C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Reichle, Donna R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Shriner, Carole R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    1981-01-01

    The purpose of this report is to provide summary information for use by potential developers and regulators of small-scale hydroelectric projects (defined as existing dams that can be retrofitted to a total site capacity of ≤30 MW), where turbine-related mortality of fish is a potential issue affecting site-specific development. Mitigation techniques for turbine-related mortality are not covered in this report.

  12. Environmental health and hazardous waste issues related to the U.S.-Mexico border.

    Science.gov (United States)

    Carter, D E; Peña, C; Varady, R; Suk, W A

    1996-06-01

    Environmental health and environmental quality issues along the U.S.-Mexico border have been of concern for several years. The enactment of the North American Free Trade Agreement and the presence of the maquiladoras (foreign-owned industries using imported raw materials) have intensified those concerns recently. Efforts to assess these issues are complicated by the fact that many of the issues affecting the border region are within federal jurisdiction, but the problems are regional and local in nature. Thus, state and local governments become involved with public concerns about real and potential problems. One major problem is that environmental health data from this region are lacking, particularly from Mexico. Some new agencies such as the Border Environment Cooperation Commission, the United States-Mexico Border Health Commission, and the North American Commission on Environmental Cooperation have joined several existing agencies at the federal and state level to address environmental quality and health. Several studies have been initiated to determine air and water quality, but little is being done in the areas of hazardous waste and health assessment. Several problems are anticipated in the generation of such data, such as its format and accessibility. Data gaps and research needs are discussed.

  13. Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant caucasians

    DEFF Research Database (Denmark)

    Ek, J; Andersen, G; Urhammer, S A

    2001-01-01

    We examined whether the Pro12-Ala polymorphism of the human peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene was related to altered insulin sensitivity among glucose-tolerant subjects or a lower accumulated incidence or prevalence of IGT and Type II (non-insulin-dependent) dia......-insulin-dependent) diabetes mellitus among Scandinavian Caucasians....

  14. Lower concentrations of blueberry polyphenolic-rich extract differentially alter HepG2 cell proliferation and expression of genes related to cell-cycle, oxidation and epigenetic machinery

    Science.gov (United States)

    In vitro cancer models have been used to study the effect of relatively high concentrations (>200 ug/ml) of phenolic plant extracts upon cell proliferation. In this study we report that the treatment of human hepatocarcinoma HepG2 cells with lower concentrations of blueberry phenolic extract (6.5-10...

  15. Fissile material disposition and proliferation risk

    Energy Technology Data Exchange (ETDEWEB)

    Dreicer, J.S.; Rutherford, D.A. [Los Alamos National Lab., NM (United States). NIS Div.

    1996-05-01

    The proliferation risk of a facility is dependent on the material attractiveness, level of safeguards, and physical protection applied to the material in conjunction with an assessment of the impact of the socioeconomic circumstances and threat environment. Proliferation risk is a complementary extension of proliferation resistance. The authors believe a better determination of nuclear material proliferation can be achieved by establishing the proliferation risk for facilities that contain nuclear material. Developing a method that incorporates the socioeconomic circumstances and threat environment inherent to each country enables a global proliferation assessment. In order to effectively reduce the nuclear danger, a broadly based set of criteria is needed that provides the capability to relatively assess a wide range of disposition options/facilities in different countries and still ensure a global decrease in proliferation risk for plutonium.

  16. Fissile material disposition and proliferation risk

    International Nuclear Information System (INIS)

    Dreicer, J.S.; Rutherford, D.A.

    1996-01-01

    The proliferation risk of a facility is dependent on the material attractiveness, level of safeguards, and physical protection applied to the material in conjunction with an assessment of the impact of the socioeconomic circumstances and threat environment. Proliferation risk is a complementary extension of proliferation resistance. The authors believe a better determination of nuclear material proliferation can be achieved by establishing the proliferation risk for facilities that contain nuclear material. Developing a method that incorporates the socioeconomic circumstances and threat environment inherent to each country enables a global proliferation assessment. In order to effectively reduce the nuclear danger, a broadly based set of criteria is needed that provides the capability to relatively assess a wide range of disposition options/facilities in different countries and still ensure a global decrease in proliferation risk for plutonium

  17. U.S. Public Relations from an International Perspective: Curricular Issues and Objectives.

    Science.gov (United States)

    Pratt, Cornelius B.; Ogbondah, Chris W.

    This paper establishes a rationale for international public relations courses in the curricula of university public relations education in the U.S. and outlines the content of such courses. Disagreements between practitioners and educators on a blueprint for public relations education are documented. Developments pointing to a crucial need for…

  18. The separation of nuclear power from nuclear proliferation

    International Nuclear Information System (INIS)

    Starr, C.

    1979-01-01

    There exists world wide a strong common desire to limit nuclear weapons proliferation so as to inhibit or remove the threat of nuclear warfare. While this is a primary international political objective, there has also developed a secondary objective to limit any potential contribution to such nuclear weapons proliferation which might arise by the diversion of weapons material from the civilian nuclear power fuel cycle. This secondary objective is the basis of the present US government policy to defer the reprocessing of nuclear fuels anywhere. This policy has been generally recognized as a temporary expedient to provide time for international reexamination of the problems of weapons proliferation associated with nuclear power. A successful development of the proposed combination of the Fast Breeder Reactor and the Civex fuel reprocessing facility would provide an economical nuclear power source for many centuries which inherently separates nuclear power from the issue of weapons material diversion and proliferation. Further, by so doing, it permits great flexibility in international and national planning for nuclear power, as the issues of fuel dependence and terrorist and subnational diversions disappear. In addition, the expansion of the FBR/Civex system would eat into the LWR spent fuel stockpile, diminishing steadily this relatively accessible plutonium source. And finally, a rapid development of the FBR/Civex for the above reasons would substantially reduce the worldwide concern as to the adequacy of uranium ore supply. (Auth.)

  19. North Korea: a mercenary proliferator?

    International Nuclear Information System (INIS)

    Hemez, Remy

    2015-01-01

    After having recalled that North Korea possesses a rather advanced ballistic programme which has been started in the 1970 with the Chinese support, that North Korea is the fourth world producer of ballistic missiles, the author outlines that this country has become a major proliferator as it exports this production to different States and non-State actors. He recalls the long history of relationships between North Korea and terrorist organisations (even during the Cold War), comments the current and major support of North Korea to Hamas and Hezbollah in Gaza and in Lebanon. These relationships are then related with those these both organisations have with Syria and Iran who are in fact the relays between them and North Korea. The author explains why Hamas and Hezbollah must buy their weapons to such a far country: Iran is submitted to international sanctions, Iran and Syria want to avoid being banned from the international community for selling weapon to a terrorist (or so-said) organisation, and prices are rather competitive. If North Korea is also submitted to international sanctions, weapon smuggling seems to be institutional in this country. The author finally briefly evokes the issue of chemical weapons: North Korea possesses few thousand tonnes of these weapons, and could export them to non-state organisations

  20. Safety issues related to the intermediate heat storage for the EU DEMO

    Energy Technology Data Exchange (ETDEWEB)

    Carpignano, Andrea [NEMO group, Dipartimento Energia, Politecnico di Torino, C.so Duca degli Abruzzi 24, 10129 Torino (Italy); Pinna, Tonio [ENEA, 00044 Frascati (Italy); Savoldi, Laura; Sobrero, Giulia; Uggenti, Anna Chiara [NEMO group, Dipartimento Energia, Politecnico di Torino, C.so Duca degli Abruzzi 24, 10129 Torino (Italy); Zanino, Roberto, E-mail: roberto.zanino@polito.it [NEMO group, Dipartimento Energia, Politecnico di Torino, C.so Duca degli Abruzzi 24, 10129 Torino (Italy)

    2016-11-01

    Highlights: • IHS affects only the PHTS and the BoP (Balance of Plant). • PIEs list does not change but IHS influences PIEs evolution. • Additional issues to be addressed in PIEs study due to the implementation of HIS. • No safety/operational major obstacles were found for IHS concept. - Abstract: The functional deviations able to compromise system safety in the EU DEMO Primary Heat Transfer System (PHTS) with intermediate heat storage (IHS) based on molten salts are identified and compared to the deviations identified with PHTS without IHS. The resulting safety issues for the Balance of Plant (BoP) have been taken into account. Functional Failure Mode and Effects Analysis (FFMEA) is used to highlight the Postulated Initiating Events (PIE) of incident/accident sequences and to provide some safety insights during the preliminary design. The architecture of the system with IHS does not introduce new PIE with respect to the case without IHS, but it modifies some of them. In particular the two Postulated Initiating Events that are affected by the presence of IHS are the LOCA in the tubes of the HX between primary and intermediate circuit and the loss of heat sink for the first wall or the breeding zone. In fact the IHS introduces some advantages concerning the stability of the secondary circuit, but some weaknesses are associated to the physical-chemical nature of molten salts, especially oxidizing power, corrosive nature and risk of solidification. These issues can be managed in the design by the introduction of new safety functions.

  1. Model development for quantitative evaluation of proliferation resistance of nuclear fuel cycles

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Won Il; Kim, Ho Dong; Yang, Myung Seung

    2000-07-01

    This study addresses the quantitative evaluation of the proliferation resistance which is important factor of the alternative nuclear fuel cycle system. In this study, model was developed to quantitatively evaluate the proliferation resistance of the nuclear fuel cycles. The proposed models were then applied to Korean environment as a sample study to provide better references for the determination of future nuclear fuel cycle system in Korea. In order to quantify the proliferation resistance of the nuclear fuel cycle, the proliferation resistance index was defined in imitation of an electrical circuit with an electromotive force and various electrical resistance components. The analysis on the proliferation resistance of nuclear fuel cycles has shown that the resistance index as defined herein can be used as an international measure of the relative risk of the nuclear proliferation if the motivation index is appropriately defined. It has also shown that the proposed model can include political issues as well as technical ones relevant to the proliferation resistance, and consider all facilities and activities in a specific nuclear fuel cycle (from mining to disposal). In addition, sensitivity analyses on the sample study indicate that the direct disposal option in a country with high nuclear propensity may give rise to a high risk of the nuclear proliferation than the reprocessing option in a country with low nuclear propensity.

  2. Model development for quantitative evaluation of proliferation resistance of nuclear fuel cycles

    International Nuclear Information System (INIS)

    Ko, Won Il; Kim, Ho Dong; Yang, Myung Seung

    2000-07-01

    This study addresses the quantitative evaluation of the proliferation resistance which is important factor of the alternative nuclear fuel cycle system. In this study, model was developed to quantitatively evaluate the proliferation resistance of the nuclear fuel cycles. The proposed models were then applied to Korean environment as a sample study to provide better references for the determination of future nuclear fuel cycle system in Korea. In order to quantify the proliferation resistance of the nuclear fuel cycle, the proliferation resistance index was defined in imitation of an electrical circuit with an electromotive force and various electrical resistance components. The analysis on the proliferation resistance of nuclear fuel cycles has shown that the resistance index as defined herein can be used as an international measure of the relative risk of the nuclear proliferation if the motivation index is appropriately defined. It has also shown that the proposed model can include political issues as well as technical ones relevant to the proliferation resistance, and consider all facilities and activities in a specific nuclear fuel cycle (from mining to disposal). In addition, sensitivity analyses on the sample study indicate that the direct disposal option in a country with high nuclear propensity may give rise to a high risk of the nuclear proliferation than the reprocessing option in a country with low nuclear propensity

  3. United Nations study on disarmament and non-proliferation education

    International Nuclear Information System (INIS)

    2003-01-01

    Science and technology transformed the world in the twentieth century. Living standards improved but warfare was rendered more deadly. Weapons of mass destruction - biological, chemical and nuclear - and their means of delivery were developed, as ever more sophisticated conventional armaments were produced and disseminated. The horrors and destruction of armed conflict persist. The need for disarmament and non-proliferation education and training has never been greater. Indeed, changing concepts and perceptions of security and threat magnify the urgency for new thinking to pursue disarmament and non-proliferation goals. More than a decade after the end of the cold war and at the start of the twenty- first century, there is a pressing need to combat ignorance, complacency and a culture of violence. These can be countered through long-term programmes of education and training, especially those related to disarmament and non- proliferation of weapons of mass destruction and their means of delivery, with a view to their reduction and complete elimination. At the same time, concern has heightened over the global threat of the excessive and destabilizing proliferation of conventional weapons, especially small arms and light weapons, rendering more acute the need to combat such proliferation in a sustained way through disarmament and non-proliferation education and training. Additionally there is a need to raise awareness of new challenges to international security and the process of disarmament. Among them, terrorism, with the possibility of the use of weapons of mass destruction, is a source of particular concern. Other challenges, such as organized crime, poverty, human rights abuses and environmental concerns must also be taken into account. Education and training remain important but under utilized tools for promoting peace, disarmament and non-proliferation. The present report addresses that issue and proposes ideas for action

  4. Regulatory issues associated with exclusion, exemption, and clearance related to the mining and minerals processing industries

    International Nuclear Information System (INIS)

    Metcalf, P.; Woude, S. van der; Keenan, N.; Guy, S.

    1997-01-01

    The concepts of exclusion, exemption and clearance have been established in international recommendations and, standards for radiation protection and the management of radioactive waste in recent years. The consistent application of these concepts has given rise to various problems in different spheres of use. This is particularly the case in the mining and minerals processing industries dealing with materials exhibiting elevated concentrations of naturally occurring radionuclides. This paper takes the South African mining industry as an example and highlights some of the issues that have arisen in applying these concepts within a regulatory control regime. (author)

  5. Technical and perceptual issues on head-related transfer functions sets for use in binaural synthesis

    DEFF Research Database (Denmark)

    Toledo, Daniela

    of binaural synthesis in providing a realistic and/or convincing virtual sonic experience relies largely on technical and perceptual issues inherent to the HRTFs and their use, particularly on how well the spectral features of the HRTFs used match those of the listener. This PhD thesis focused on identifying...... the spectral features that cue sound localization in the mid-sagittal plane. Listening tests were conducted from which groups of individual and non-individual HRTFs that evoked the same direction were obtained. Analysis of these HRTFs suggested that the relevant spectral cues covered a broad range...

  6. Experimental activities related to safety systems of PWR NPPs (900 MWe). Sump screen plugging issue

    International Nuclear Information System (INIS)

    Vicena, I.; Soltesz, B.; Batalik, J.; Gubco, V.; Liska, M.; Galusekova, D.; Klementova, A.; Mattei, J. M.; Armand, Y.

    2006-01-01

    In this presentation authors present the sump plugging issue - ability of the filtration systems to catch debris (generated during the LOCA accident) to maintain the recirculating water the CSS and the ECCS need. Assessment has been focused upon the CPY series 900 MW e (28 reactors). Typical involved debris is: - the insulation for all the plants is made of glass wool (45 kg/m 3 ). Glass-wool is contained in sheet metal panels using attachment mechanism; - paints; - concrete; -dust. Effect of water chemistry on debris and filtration process ELISA loop is described.

  7. Title V Applicability Issues Related to the Cincinnati/Northern Kentucky International Airport

    Science.gov (United States)

    This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  8. GRS/ISTec strategy for the treatment of gas-related issues for repositories located in rock salt

    International Nuclear Information System (INIS)

    Muller-Lyda, I.; Javeri, V.; Muller, W.

    2001-01-01

    The treatment of gas-related issues for repositories located in rock salt by GRS and ISTec has followed a strategy which has been developed with increasing complexity and degree of detail in the past. The strategy today clearly indicates the direction to establish a comprehensive safety case and the work that remains to be done. For gas generation mainly long-term aspects are an issue to increase accuracy of predictions. Physical modelling especially for HLW is still incomplete with regard to the coupling of fluid flow with geomechanics, solution/precipitation effects and geochemistry. The appropriate tools to transform the physical models into numerical solutions are at hand in principle but have to be further developed collaterally to the physical modelling. The first full-scale demonstration of safety regarding gas issues in rock salt will have to be provided for the licensing of the Morsleben repository shut-down in the near future. (authors)

  9. The Korean Study of Women’s Health-Related Issues (K-Stori: Rationale and Study Design

    Directory of Open Access Journals (Sweden)

    Ha Na Cho

    2017-06-01

    Full Text Available Abstract Background Measures to address gender-specific health issues are essential due to fundamental, biological differences between the sexes. Studies have increasingly stressed the importance of customizing approaches directed at women’s health issues according to stages in the female life cycle. In Korea, however, gender-specific studies on issues affecting Korean women in relation to stages in their life cycle are lacking. Accordingly, the Korean Study of Women’s Health-Related Issues (K-Stori was designed to investigate life cycle-specific health issues among women, covering health status, awareness, and risk perceptions. Methods K-Stori was conducted as a nationwide cross-sectional survey targeting Korean women aged 14–79 years. Per each stage in the female life cycle (adolescence, childbearing age, pregnancy & postpartum, menopause, and older adult stage, 3000 women (total 15,000 were recruited by stratified multistage random sampling for geographic area based on the 2010 Resident Registration Population in Korea. Specialized questionnaires per each stage (total of five were developed in consultation with multidisciplinary experts and by reflecting upon current interests into health among the general population of women in Korea. This survey was conducted from April 1 to June 31, 2016, at which time investigators from a professional research agency went door-to-door to recruit residents and conducted in-person interviews. Discussion The study’s findings may help with elucidating health issues and unmet needs specific to each stage in the life cycle of Korean women that have yet to be identified in present surveys.

  10. Kyoto protocol and related issues; Chikyu ondanka boshi Kyoto kaigi (COP3) to sono kadai

    Energy Technology Data Exchange (ETDEWEB)

    Ninomiya, Y. [Global Industrial Social Progress Research Institute, Tokyo (Japan)

    1997-09-30

    The Third Session of the Conference of the Parties to the United Nations Framework Convention on Climate Change (COP3) will be held in Kyoto in December 1997. Described herein are the current status and issues of the convention. USA and Japan, which hold important keys to set up the abatement target, have issued no proposals concretely at the current AGBM (Ad-hoc Group Berlin Mandate) 7, and the conference for the concrete targets will be decided in the next AGBM 8 to be held in October. The final target will be set by the ministerial segment of COP3, because the negotiations for the treaty are political in nature. USA proposes reduction at a uniform, realistic rate, and Japan proposes reduction at a uniform rate or setting up the emission target per capita, each being different from reduction at a much higher uniform rate proposed by EU. Within EU, however, 10% out of 15% reduction rate it proposes is agreed by the member countries, and the remaining rate of % may not be agreed. It is necessary for the advanced parties to set up realistic and legally binding solutions, including ratification by USA, which can persuade the developing countries. tab.1

  11. How would we deal with radiation related issues in high school educational programs?

    Energy Technology Data Exchange (ETDEWEB)

    Saeki, Kuniko [Attached High School of Akita Keizai Houka Univ., Akita (Japan)

    1999-09-01

    Current educational curriculum will be more improved and the materials in schools will be somewhat different by the year of 2002 when students have two days off in a week. It is a well known fact that recent Japanese people's level of understanding about Science and Technology is the second from the bottom among OECD nations and, as a matter of fact, few schools are dealing with scientific issues such as atomic energy or radiation. High school teachers need to survey what students know about atomic power and radiation, how deep they studied in previous schools and what kind of interest they have in conservation of world energy sources or environmental issues discussed today. Through questionnaires to 328 students, it became clear that they were most interesting to the effect of radiation or radioactivity on any kind of things in the environment, and that they want to know solutions for those problems such as greenhouse effect, ozone layers and Garbage disposal. (M. Suetake)

  12. Hydrogen related safety issues in the context of containments of Indian PHWRs

    International Nuclear Information System (INIS)

    Markendeya, S.G.; Ghosh, A.K.; Kushwaha, H.S.; Venkat Raj, V.

    2002-01-01

    Full text: Assessment of risk due to hydrogen released during postulated hypothetical accident scenarios in the nuclear power plants (NPPs) has been an important area of R and D studies world over. The issues, such as appropriate methodologies for estimation of hydrogen source term and for hydrogen dispersion calculations, technology development for hydrogen mitigation in containment of NPPs and assessment of damage due to deflagration/detonation of hydrogen (if it occurs) are being addressed as a part of some of the multidisciplinary study programs currently underway in BARC. While a significant overall progress has been achieved in general as a result of these programs, requirements of further fine-tuning of these studies have also emerged. The present paper takes a brief look at the current state-of the-art technology available to address these issues. The progress of R and D studies underway at BARC has also been critically reviewed in the paper to bring out necessary planning of further studies so as to enhance the safety of Indian NPPs

  13. The threat of proliferation

    International Nuclear Information System (INIS)

    Palme, Olof.

    1986-01-01

    The paper on the threat of proliferation, is a keynote speech delivered to the Colloquium on Nuclear War, Nuclear Proliferation and their Consequences, Geneva, 1985. Topics discussed in the address include: nuclear weapons, nuclear war, terrorists, Non-Proliferation Treaty, nuclear disarmament, and leadership in world affairs. (UK)

  14. Students as Non-Standard Employees. Exploring Work Related Issues in Students’ Perceptions on their Term-time Job

    DEFF Research Database (Denmark)

    Winkler, Ingo

    2008-01-01

    The article presents the results of an explorative study that aimed at exploring work related issues in students’ perceptions of their job as atypical employees. An individual picture of the experienced work reality of students is drawn according to work task, flexible working hours, instructions...... and training opportunities, students’ relations to other employees, and social integration. By adopting a qualitative design, I was able to emphasize the subjective perspective of students describing their very own experiences as flexible workers. The study revealed various perceptions of students working...... as flexible employees and related this picture to current empirical and theoretical research in the field of non-standard employment....

  15. Ethical issues in the development and implementation of nutrition-related public health policies and interventions: A scoping review

    Science.gov (United States)

    Peña-Rosas, Juan Pablo; Saxena, Abha; Zamora, Gerardo

    2017-01-01

    Background The limited integration of ethics in nutrition-related public health policies and interventions is one major concern for those who have the task of implementing them. Ethical challenges that are overlooked during the development of such interventions could raise serious ethical issues during their implementation and even after. As a result, these decision makers need technical support and ethical guidance for adaptation of interventions to local (cultural, social, economic, etc.) contexts. Aim The goal of this scoping review is to delineate and “map” the range of ethical issues in nutrition-related public health interventions, as well as the range of the various fields in which they may arise. Methods A scoping review of empirical research and conceptual literature was conducted following the framework of Arksey and O’Malley. Searches using PubMed with Medical Subject Headings (MeSH) categories and Advanced Search Builder as well as in the Global Health Library were performed. The final sample consists of 169 publications. Results The ethics of public health prevention or treatment of obesity and non-communicable diseases is the most explicitly and frequently discussed subject. In comparison, ethical issues raised by public health interventions in the fields of undernutrition, breastfeeding, vitamin/mineral supplementation and food fortification, food security, food sustainability and food safety are addressed in a lower proportion of the sample. The results illustrate the various natures, types, and scopes of existing public health nutrition-related interventions, and the various ethical issues that may be raised by these interventions, in addition to the numerous and different contexts in which they may be implemented. Discussion The ethical issues faced in the development and implementation of nutrition-related public health interventions are varied and cannot be equated with, nor generalized about, when dealing with specific activities in this

  16. Ethical issues in the development and implementation of nutrition-related public health policies and interventions: A scoping review.

    Science.gov (United States)

    Hurlimann, Thierry; Peña-Rosas, Juan Pablo; Saxena, Abha; Zamora, Gerardo; Godard, Béatrice

    2017-01-01

    The limited integration of ethics in nutrition-related public health policies and interventions is one major concern for those who have the task of implementing them. Ethical challenges that are overlooked during the development of such interventions could raise serious ethical issues during their implementation and even after. As a result, these decision makers need technical support and ethical guidance for adaptation of interventions to local (cultural, social, economic, etc.) contexts. The goal of this scoping review is to delineate and "map" the range of ethical issues in nutrition-related public health interventions, as well as the range of the various fields in which they may arise. A scoping review of empirical research and conceptual literature was conducted following the framework of Arksey and O'Malley. Searches using PubMed with Medical Subject Headings (MeSH) categories and Advanced Search Builder as well as in the Global Health Library were performed. The final sample consists of 169 publications. The ethics of public health prevention or treatment of obesity and non-communicable diseases is the most explicitly and frequently discussed subject. In comparison, ethical issues raised by public health interventions in the fields of undernutrition, breastfeeding, vitamin/mineral supplementation and food fortification, food security, food sustainability and food safety are addressed in a lower proportion of the sample. The results illustrate the various natures, types, and scopes of existing public health nutrition-related interventions, and the various ethical issues that may be raised by these interventions, in addition to the numerous and different contexts in which they may be implemented. The ethical issues faced in the development and implementation of nutrition-related public health interventions are varied and cannot be equated with, nor generalized about, when dealing with specific activities in this field. More importantly, these ethical issues

  17. Ethical issues in the development and implementation of nutrition-related public health policies and interventions: A scoping review.

    Directory of Open Access Journals (Sweden)

    Thierry Hurlimann

    Full Text Available The limited integration of ethics in nutrition-related public health policies and interventions is one major concern for those who have the task of implementing them. Ethical challenges that are overlooked during the development of such interventions could raise serious ethical issues during their implementation and even after. As a result, these decision makers need technical support and ethical guidance for adaptation of interventions to local (cultural, social, economic, etc. contexts.The goal of this scoping review is to delineate and "map" the range of ethical issues in nutrition-related public health interventions, as well as the range of the various fields in which they may arise.A scoping review of empirical research and conceptual literature was conducted following the framework of Arksey and O'Malley. Searches using PubMed with Medical Subject Headings (MeSH categories and Advanced Search Builder as well as in the Global Health Library were performed. The final sample consists of 169 publications.The ethics of public health prevention or treatment of obesity and non-communicable diseases is the most explicitly and frequently discussed subject. In comparison, ethical issues raised by public health interventions in the fields of undernutrition, breastfeeding, vitamin/mineral supplementation and food fortification, food security, food sustainability and food safety are addressed in a lower proportion of the sample. The results illustrate the various natures, types, and scopes of existing public health nutrition-related interventions, and the various ethical issues that may be raised by these interventions, in addition to the numerous and different contexts in which they may be implemented.The ethical issues faced in the development and implementation of nutrition-related public health interventions are varied and cannot be equated with, nor generalized about, when dealing with specific activities in this field. More importantly, these

  18. Riboflavin Depletion Promotes Tumorigenesis in HEK293T and NIH3T3 Cells by Sustaining Cell Proliferation and Regulating Cell Cycle-Related Gene Transcription.

    Science.gov (United States)

    Long, Lin; He, Jian-Zhong; Chen, Ye; Xu, Xiu-E; Liao, Lian-Di; Xie, Yang-Min; Li, En-Min; Xu, Li-Yan

    2018-05-07

    Riboflavin is an essential component of the human diet and its derivative cofactors play an established role in oxidative metabolism. Riboflavin deficiency has been linked with various human diseases. The objective of this study was to identify whether riboflavin depletion promotes tumorigenesis. HEK293T and NIH3T3 cells were cultured in riboflavin-deficient or riboflavin-sufficient medium and passaged every 48 h. Cells were collected every 5 generations and plate colony formation assays were performed to observe cell proliferation. Subcutaneous tumorigenicity assays in NU/NU mice were used to observe tumorigenicity of riboflavin-depleted HEK293T cells. Mechanistically, gene expression profiling and gene ontology analysis were used to identify abnormally expressed genes induced by riboflavin depletion. Western blot analyses, cell cycle analyses, and chromatin immunoprecipitation were used to validate the expression of cell cycle-related genes. Plate colony formation of NIH3T3 and HEK293T cell lines was enhanced >2-fold when cultured in riboflavin-deficient medium for 10-20 generations. Moreover, we observed enhanced subcutaneous tumorigenicity in NU/NU mice following injection of riboflavin-depleted compared with normal HEK293T cells (55.6% compared with 0.0% tumor formation, respectively). Gene expression profiling and gene ontology analysis revealed that riboflavin depletion induced the expression of cell cycle-related genes. Validation experiments also found that riboflavin depletion decreased p21 and p27 protein levels by ∼20%, and increased cell cycle-related and expression-elevated protein in tumor (CREPT) protein expression >2-fold, resulting in cyclin D1 and CDK4 levels being increased ∼1.5-fold, and cell cycle acceleration. We also observed that riboflavin depletion decreased intracellular riboflavin levels by 20% and upregulated expression of riboflavin transporter genes, particularly SLC52A3, and that the changes in CREPT and SLC52A3 correlated with

  19. Director`s series on proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, K.C.; Price, M.E. [eds.

    1994-12-27

    The Director`s Series on Proliferation is an occasional publication of essays on the topics of nuclear, chemical, biological, and missile proliferation. The seven papers presented in this issue cover the following topics: Should the Treaty on the Nonproliferation of Nuclear Weapons (NPT) be amended?; NPT extension - Legal and procedural issues; An Indonesian view of NPT review conference issues; The treaty of Tlatelolco and the NPT - Tools for peace and development; Perspectives on cut-off, weapons dismantlement, and security assurances; Belarus and NPT challenges; A perspective on the chemical weapons convention - Lessons learned from the preparatory commission.

  20. ATTITUDES OF PEOPLE IN THE THAI CONSTRUCTION INDUSTRY SECTOR ON ISSUES RELATED TO DELAY IN THE APPROVAL OF SUBMITTALS

    Directory of Open Access Journals (Sweden)

    Visuth Chovichien

    2011-10-01

    Full Text Available This study investigated attitudes in the Thai construction industry sector towards 21 issues related to “delay in the approval of submittals” that may initiate conflicts among various parties. Knowledge gained from this study can be applied to the analyses of the completeness and appropriateness of contract conditions and to improve contract drafting. The attitudes of the majority of people in the industry towards several issues related to the time frame for the approval of submittals, compensation for cost increases and profit losses, and time frames for notifications of delayed approval and claim submission were found to be inconsistent with existing conditions in standard contracts. Various issues that are not covered in the standard contract forms, such as the time frame for providing reminders and the types of time loss and direct costs that can be claimed, were also found to have high tendencies to initiate conflicts between contracting parties. Finally, we also found that the organisational affiliation of the respondents (i.e., employer or contractor influenced their attitudes towards some, but not all, contractual issues.

  1. Individual, work-, and flight-related issues in F-16 pilots reporting neck pain

    NARCIS (Netherlands)

    de Loose, Veerle; van den Oord, Marieke; Burnotte, Frédéric; van Tiggelen, Damien; Stevens, Veerle; Cagnie, Barbara; Witvrouw, Erik; Danneels, Lieven

    2008-01-01

    INTRODUCTION: Neck pain is a common problem in F-16 pilots. A cross-sectional survey was used to determine the self-reported 1-yr prevalence of neck pain and to compare individual, work-related, and flight-related characteristics in F-16 pilots with and without neck pain. METHOD: There were 90 male

  2. Relations between Parenting Style and Children's Play Behavior. Issues in Education.

    Science.gov (United States)

    Clawson, Mellisa A.; Robila, Mihaela

    2001-01-01

    Studied Baumrind's approach to parenting style to examine the relations between parenting style and preschool children's social competence manifested through peer play. Found that mothers' and fathers' parenting style is related to children's play with peers, with an authoritative parenting style correlating to more complex levels of play. (SD)

  3. The Quality of Online Health-Related Information – an Emergent Consumer Health Issue

    Directory of Open Access Journals (Sweden)

    Nădăşan Valentin

    2016-12-01

    Full Text Available The Internet has become one of the main means of communication used by people who search for health-related information. The quality of online health-related information affects the users’ knowledge, their attitude, and their risk or health behaviour in complex ways and influences a substantial number of users in their decisions regarding diagnostic and treatment procedures.

  4. Director`s series on proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, K.C. [ed.

    1993-09-07

    Two essays are included in this booklet. Their titles are ``The Dynamics of the NPT Extension Decision`` and ``North Korea`s Nuclear Gambit.`` The first paper discusses the conference to be held in 1995 to review the Nuclear Non-Proliferation Treaty (NPT) which will decide whether the treaty shall continue in force indefinitely, or shall be extended for an additional fixed period or periods. Topics relevant to this discussion are: Arms control issues, the nuclear test ban, the limited test ban treaty, the French nuclear testing moratorium, former Soviet nuclear weapons, Iraq, North Korea, nuclear-weapon-free zones, security, controls on nuclear weapon materials, peaceful uses of nuclear energy, safeguards, politics, and organizational and procedural issues. The second paper examines short, medium, and long term issues entailed in Korea`s nuclear proliferation. Topics considered include: Korean unification, North Korean politics, the nuclear issue as leverage, and the Nuclear Non- Proliferation Treaty.

  5. Analysis of articles in weekly magazines on scientific issues related to Fukushima nuclear power plant accident

    International Nuclear Information System (INIS)

    Sano, Kazumi; Kikuchi, Macoto

    2012-01-01

    The large area was polluted by the radioactive fallout released after the nuclear fuel meltdown of Fukushima first nuclear plant of Tokyo electric power company. The news media that reported the accident were required to have scientific knowledge on the structure of the nuclear reactor and the physics and health issues of the radioactivity. In this paper, we focus on how the weekly magazines reported this critical accident. The weekly magazines are not regarded as a neutral news media. Rather, their articles in general strongly reflect the editorial opinions. In this sense, the weekly magazines are 'biased media'. So, there are many points to discuss from the view point of the science communication. We analyze the articles appeared in the seven major weekly magazines published during the first half year after the earthquake. We found that the differences in the scientific literacy between magazines are reflected, for example, in selection of the experts who made comments in articles. (author)

  6. Geometrically motivated hyperbolic coordinate conditions for numerical relativity: Analysis, issues and implementations

    International Nuclear Information System (INIS)

    Bona, Carles; Lehner, Luis; Palenzuela-Luque, Carlos

    2005-01-01

    We study the implications of adopting hyperbolic-driver coordinate conditions motivated by geometrical considerations. In particular, conditions that minimize the rate of change of the metric variables. We analyze the properties of the resulting system of equations and their effect when implementing excision techniques. We find that commonly used coordinate conditions lead to a characteristic structure at the excision surface where some modes are not of outflow type with respect to any excision boundary chosen inside the horizon. Thus, boundary conditions are required for these modes. Unfortunately, the specification of these conditions is a delicate issue as the outflow modes involve both gauge and main variables. As an alternative to these driver equations, we examine conditions derived from extremizing a scalar constructed from Killing's equation and present specific numerical examples

  7. Barriers to radiotherapy utilization: Consumer perceptions of issues influencing radiotherapy-related decisions.

    Science.gov (United States)

    Sundaresan, Puma; King, Madeleine; Stockler, Martin; Costa, Daniel; Milross, Christopher

    2017-10-01

    Radiation therapy (RT) is an essential and cost-effective cancer treatment, but it is underutilized in Australia. We aimed to quantify consumers' perceptions of factors that influence RT decisions. A cross-sectional, survey-based study was conducted in March-August 2012. Potential participants were invited to complete an electronic survey disseminated through multiple patient support and advocacy groups throughout New South Wales (NSW), Australia. Study invitations were also placed in local newspapers across NSW with hard copy surveys mailed to respondents. Current or past cancer patients (and carers) who had been offered RT were eligible to participate regardless of their RT decision. Of the 1191 participants (electronic, n = 1153; hard copy, n = 38), 91% were female, most (88%) were current or past patients, and 78% had accepted RT. Issues commonly perceived to be moderate to strong influencers of RT decisions were: concern about acute and long-term side effects; management of side effects; fear and anxiety regarding RT; lack of awareness of RT; lack of local availability of RT; and lack of RT information resources. Those who declined RT were significantly more likely to highlight practical difficulties with receiving RT. Although availability of RT is well recognized, other issues such as fear and anxiety about RT and perceived side effects appear to feature prominently in consumers' decisions. Perceived practical difficulties with receiving RT may have influenced those who declined RT. There may be a need for information resources, support services and interventions to increase awareness of RT. © 2016 John Wiley & Sons Australia, Ltd.

  8. Space Station Engineering Design Issues

    Science.gov (United States)

    Mcruer, Duane T.; Boehm, Barry W.; Debra, Daniel B.; Green, C. Cordell; Henry, Richard C.; Maycock, Paul D.; Mcelroy, John H.; Pierce, Chester M.; Stafford, Thomas P.; Young, Laurence R.

    1989-01-01

    Space Station Freedom topics addressed include: general design issues; issues related to utilization and operations; issues related to systems requirements and design; and management issues relevant to design.

  9. IAEA safeguards related to the Non-Proliferation Treaty of Nuclear Weapons- T.N.P. and the Treaty for the Prohibition of Nuclear Weapons in Latin America-Tlatelolco

    International Nuclear Information System (INIS)

    Rodrigues, M.D.F.

    1978-04-01

    The application of safeguards, focusing mainly the causes that gave origin to this type of control, is studied. The safeguard procedures used by the IAEA are also given, relative to the Treaty for the Prohibition of Nuclear Weapons in Latin America - Tlatelolco, the Non-Proliferation Treaty of Nuclear Weapons - T.N.P. and the Euratom safeguards. Some consideration is given to the organizations related to safeguards application such as IAEA, OPANAL and Euratom, their functions and aims. (F.E.) [pt

  10. EPA Issues November 15, 2010 Memorandum: Integrated Reporting and Listing Decisions Related to Ocean Acidification

    Science.gov (United States)

    The memorandum provides information to assist regions and states in preparing and reviewing Integrated Reports related to ocean acidification (OA) impacts under Sections 303(d), 305(b) and 314 of the Clean Water Act (CWA).

  11. Issues Related to Experience & Automated Agent Technology in Synthetic Task Performance

    National Research Council Canada - National Science Library

    Coovert, Michael D; Riddle, Dawn L; Gordon, Thomas; Miles, Donald; Hoffman, Kimberly; King, Thomas; Elliott, Linda; Dalrymple, Mathieu; Schiflett, Samual; Chaiken, Scott

    2001-01-01

    .... Elliott, Stoyen and Chaiken (2000) note the limits of human cognitive processing relative to this demand and suggest agent technology has the potential to offer effective information and decision support the human operator...

  12. Non Proliferation of Nuclear

    International Nuclear Information System (INIS)

    Bambang S Irawan

    2004-01-01

    Non-Proliferation Treaty of Nuclear Weapons is the international community's efforts to maintain the security of the world, in order to prevent the spread of nuclear technology and the use of nuclear weapons, promoting cooperation for the use of nuclear peaceful purposes, build mutual trust (Confidence Building Measures) as well as to achieve the ultimate goal of disarmament overall (General and Complete Disarmament). Addressing the post-WTC tragedy, 11 September 2001, the Indonesian government should set up a National Measures (National Action Plan), among others formed the National Security Council and NBC Counter Proliferation Unit, or the National Authority for Nuclear Treaty, preparing national legislation, to prevent the abuse nuclear materials for terrorist acts, prevent Illicit Trafficking of Nuclear materials, developed a National Preparedness and Emergency Response Management in the event of a nuclear accident or attack by the use of nuclear terrorism. Importance of a National Action Plan meant the existence of a national commitment in the context of compliance with treaties and conventions which have been ratified relating to safety, security, safeguards towards a general and complete disarmament, to safeguard national security and maintain peace (safeguards) international

  13. Initiatives for proliferation prevention

    International Nuclear Information System (INIS)

    1997-04-01

    Preventing the proliferation of weapons of mass destruction is a central part of US national security policy. A principal instrument of the Department of Energy's (DOE's) program for securing weapons of mass destruction technology and expertise and removing incentives for scientists, engineers and technicians in the newly independent states (NIS) of the former Soviet Union to go to rogue countries or assist terrorist groups is the Initiatives for Proliferation Prevention (IPP). IPP was initiated pursuant to the 1994 Foreign Operations Appropriations Act. IPP is a nonproliferation program with a commercialization strategy. IPP seeks to enhance US national security and to achieve nonproliferation objectives by engaging scientists, engineers and technicians from former NIS weapons institutes; redirecting their activities in cooperatively-developed, commercially viable non-weapons related projects. These projects lead to commercial and economic benefits for both the NIS and the US IPP projects are funded in Russian, Ukraine, Kazakhstan and Belarus. This booklet offers an overview of the IPP program as well as a sampling of some of the projects which are currently underway

  14. THE UNITED RESCUE SYSTEM IN BULGARIA. CURRENT RESOURCE RELATED ISSUES AND PROSPECTIVE SOLUTIONS

    Directory of Open Access Journals (Sweden)

    Daniela Baleva

    2017-11-01

    Full Text Available The article presents some problems related to securing the Bulgarian system for disaster management with the necessary resources for its proper functioning. The main challenges for the united rescue system in the country are analyzed, including those related to ensuring the system with the necessary material, financial and human resources. Some possibilities for solving these problems with the use of funds from the European Union are presented.

  15. Psychometric evaluation of the Environmental Reality Shock-Related Issues and Concerns instrument for newly graduated nurses.

    Science.gov (United States)

    Kim, Eun-Young; Yeo, Jung Hee; Park, Hyunjeong; Sin, Kyung Mi; Jones, Cheryl B

    2018-02-01

    Reality shock is a critical representation of the gap between nursing education and clinical practice and it is important to explore the level of reality shock among nurses. However, there is no relevant instrument to assess the level of reality shock in South Korea. The purpose of this is to determine the validity and reliability of the Korean version of the Environmental Reality Shock-Related Issues and Concerns instrument. A cross-sectional study design was used in this study. The data collection was conducted in selected 15 hospitals in South Korea. A convenience sample of 216 newly graduated nurses participated in the study. The Korean version of the Environmental Reality Shock-Related Issues and Concerns instrument was developed through the forward-backward translation technique, and revision based on feedback from expert groups. The internal consistency reliability was assessed using Cronbach's alpha, and the construct validity was determined via exploratory and confirmatory factor analysis. The Korean version of the Environmental Reality Shock-Related Issues and Concerns has reliable internal consistency (Cronbach's alpha=0.91). Exploratory factor analysis revealed five factors including job, relationships, expectations, private life, and performance, which explained 61.92% of variance. The factor loadings ranged from 0.451 to 0.832. The five-factor structure was validated by confirmatory factor analysis (RMR0.9). It was concluded that the Korean version of the Environmental Reality Shock-Related Issues and Concerns instrument has satisfactory construct validity and reliability to measure the reality shock of newly graduated nurses in South Korea. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Localization of Proliferating Cells in the Inter-Vertebral Region of the Developing and Adult Vertebrae of Lizards in Relation to Growth and Regeneration.

    Science.gov (United States)

    Alibardi, Lorenzo

    2016-04-01

    New cartilaginous tissues in lizards is formed during the regeneration of the tail or after vertebral damage. In order to understand the origin of new cartilaginous cells in the embryo and after injury of adult vertebrae we have studied the distribution of proliferating cartilaginous cells in the vertebral column of embryos and adults of the lizard Anolis lineatopus using autoradiography for H3-thymidine and light and ultrastructural immunocytochemistry for 5BrdU. Proliferating sclerotomal cells initially surround the notochord in a segmental pattern and give rise to the chondrocytes of the vertebral centrum that replace the original chordal cells. Qualitative observations show that proliferating sclerotomal cells dilute the labeling up to 13 days post-injection but a few maintain the labeling as long labeling retention cells and remain in the inter-centra and perichondrium after birth. These cells supply new chondroblasts for post-natal growth of vertebrae but can also proliferate in case of vertebral damage or tail amputation in lizards, a process that sustains tail regeneration. The lack of somitic organization in the regenerating tail impedes the re-formation of a segmental vertebral column that is instead replaced by a continuous cartilaginous tube. It is hypothesized that long labeling retaining cells might represent stem/primordial cells, and that their permanence in the inter-vertebral cartilages and the nearby perichondrium in adult lizards pre-adapt these reptiles to elicit a broad cartilage regeneration in case of injury of the vertebrae. © 2016 Wiley Periodicals, Inc.

  17. Management of ethical issues related to care of seriously ill dialysis patients in free-standing facilities.

    Science.gov (United States)

    Song, Mi-Kyung; Hanson, Laura C; Gilet, Constance A; Jo, Minjeong; Reed, Teresa J; Hladik, Gerald A

    2014-09-01

    There are few data on the frequency and current management of clinical ethical issues related to care of seriously ill dialysis patients in free-standing dialysis facilities. To examine the extent of clinical ethical challenges experienced by care providers in free-standing facilities and their perceptions about how those issues are managed. A total of 183 care providers recruited from 15 facilities in North Carolina completed a survey regarding the occurrence and management of ethical issues in the past year. Care plan meetings were observed at four of the facilities for three consecutive months. Also, current policies and procedures at each of the facilities were reviewed. The two most frequently experienced challenges involved dialyzing frail patients with multiple comorbidities and caring for disruptive/difficult patients. The most common ways of managing ethical issues were discussions in care plan meetings (n = 47) or discussions with the clinic manager (n = 47). Although policies were in place to guide management of some of the challenges, respondents were often not aware of those policies. Also, although participants reported that ethical issues related to dialyzing undocumented immigrants were fairly common, no facility had a policy for managing this challenge. Participants suggested that all staff obtain training in clinical ethics and communication skills, facilities develop ethics teams, and there be clear policies to guide management of ethical challenges. The scope of ethical challenges was extensive, how these challenges were managed varied widely, and there were limited resources for assistance. Multifaceted efforts, encompassing endeavors at the individual, facility, organization, and national levels, are needed to support staff in improving the management of ethical challenges in dialysis facilities. Copyright © 2014 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  18. Marketing nutrition & health-related benefits of food & beverage products: enforcement, litigation & liability issues.

    Science.gov (United States)

    Roller, Sarah; Pippins, Raqiyyah

    2010-01-01

    Over the past decade, the liability risks associated with food and beverage product marketing have increased significantly, particularly with respect to nutrition and health-related product benefit claims. FDA and FTC enforcement priorities appear to have contributed to the increasing liability trends that are associated with these nutrition and health-related claims. This article examines key enforcement and litigation developments involving conventional food and beverage product marketing claims during the first 18 months of President Obama's administration: Part I considers FDA enforcement priorities and recent warning letters; Part II considers FTC enforcement priorities, warning letters, and consent orders; and Part III considers the relationship between FDA and FTC enforcement priorities and recent false advertising cases brought by private parties challenging nutrition and health-related marketing claims for food and beverage products. The article makes recommendations concerning ways in which food and beverage companies can help minimize liability risks associated with health-related marketing claims. In addition, the article suggests that federal policy reforms may be required to counter the perverse chilling effects current food liability trends appear to be having on health-related marketing claims for food and beverage products, and proposes a number of specific reforms that would help encourage the responsible use of well-substantiated marketing claims that can help foster healthy dietary practices. In view of the obesity prevention and other diet-related public health priorities of the Obama administration, the article suggests that this is an opportune time to address the apparent chilling effects increasing food liability risks are having on nutrition and health-related marketing claims for healthy food and beverage products, and potential adverse consequences for public health.

  19. Subway-Related Trauma: An Urban Public Health Issue with a High Case-Fatality Rate.

    Science.gov (United States)

    Rodier, Simon G; DiMaggio, Charles J; Wall, Stephen; Sim, Vasiliy; Frangos, Spiros G; Ayoung-Chee, Patricia; Bukur, Marko; Tandon, Manish; Todd, S Rob; Marshall, Gary T

    2018-05-09

    Between 1990 and 2003, there were 668 subway-related fatalities in New York City. However, subway-related trauma remains an understudied area of injury-related morbidity and mortality. The objective of this study was to characterize the injuries and events leading up to the injuries of all patients admitted after subway-related trauma. We conducted a retrospective case series of subway-related trauma at a Level I trauma center from 2001 to 2016. Descriptive epidemiology of patient demographics, incident details, injuries, and outcomes were analyzed. Over 15 years, 254 patients were admitted for subway-related trauma. The mean (standard error of the mean) age was 41 (1.0) years, 80% were male (95% confidence interval [CI] 74-84%) and median Injury Severity Score was 14 (interquartile range [IQR] 5-24). The overall case-fatality rate was 10% (95% CI 7-15%). The most common injuries were long-bone fractures, intracranial hemorrhage, and traumatic amputations. Median length of stay was 6 days (IQR 1-18 days). Thirty-seven percent of patients required surgical intervention. At the time of injury, 55% of patients (95% CI 49-61%) had a positive urine drug or alcohol screen, 16% (95% CI 12-21%) were attempting suicide, and 39% (95% CI 33-45%) had a history of psychiatric illness. Subway-related trauma is associated with a high case-fatality rate. Alcohol or drug intoxication and psychiatric illness can increase the risk of this type of injury. Copyright © 2018 Elsevier Inc. All rights reserved.

  20. 'For good and for bad': the relations between universal obligations and particular efforts in the field of nuclear non-proliferation

    International Nuclear Information System (INIS)

    Dassen Van, L.

    2005-01-01

    Full text: The world has 'nuclear non-proliferation' on its lips. Presidents, politicians, journalists and others refer to it as the number one peril in our times. This may be right or wrong but irrespective of the real salience of 'nuclear dangers' it has a grip on our minds and wallets. A long range of states now make active investments in the improvement of nuclear security; not only at home as they used to do, but even abroad in other places and countries where there is concern with regard to how safe nuclear and materials are kept and stored. This development is surely an expression of a shared broadening of our sense of responsibility beyond the narrow confines of statehood and borders, and therefore this development should please us. On the other hand, the truly universal measures and instruments of the NPT and the regime round it are in trouble. It is being stated in some quarters that the NPT is inadequate in a new era with new threats from sub-state actors. Nevertheless, the NPT is the only legal instrument that is a framework that either by itself or as a starting-point can serve as a tool box for long-term storage of the proliferation risks. The reason for this is that the NPT is an expression of fairness in terms of rights and balances for all states committed to non-proliferation. And its foundations are those of international law. To the extent the NPT is being questioned will there also be a risk that non-proliferation efforts in the framework of cooperative threat reduction and for instance global partnership will lose legitimacy; simply for the reason that only a small number of the non-proliferation concerns are given attention. This relationship between cooperative threat reduction efforts on the one hand and universal legal instruments for non-proliferation on the other is a double-edged sword. While the two can reinvigorate and strengthen each other, there is also a risk that the one - cooperative threat reduction - when given preference over

  1. Nuclear energy and nuclear weapons proliferation

    International Nuclear Information System (INIS)

    1989-01-01

    A summary of the report dispatched in the middle of 1978 by the Atlantic Council of United States, organized by North American citizens, is presented. The report considers the relation between the production of nucleoelectric energy and the capacity of proliferation of nuclear weapons. The factors which affect the grade of proliferation risk represented by the use of nuclear energy in the world comparing this risk with the proliferation risks independently of nuclear energy, are examined. (M.C.K.) [pt

  2. The historical aspects and current issues of the development of Russian-Lithuanian economic relations

    Directory of Open Access Journals (Sweden)

    Kretinin Gennady

    2012-12-01

    Full Text Available This article focuses on development of Russian-Lithuanian economic ties. The research and practical significance of this study lies in the identification of the sources of modern Russian-Lithuanian economic cooperation and the prospects of future mutually beneficial economic relations. The first attempt at establishing economic relations was made in 1919. However, young Lithuanian Republic gravitated towards the West, severing ties with the Russian market. However, the initiatives of Lithuanian authorities did not result in successful state building, and the economic situation remained unchanged. The USSR leadership made an effort to improve the living conditions in post-war Lithuania. There were some mistakes made in the relations with the local population that resulted in Lithuanians’ resistance to sovietisation. However, in the conditions of post-war restoration of national economy and acute deficit of material and human resources, the Soviet leadership managed not only to reform and develop a socialistic economy in Lithuania but also to turn it into an industrial republic with developed agriculture and modern manufacturing facilities, whose major industries manufactured products used in nuclear and space technologies, aviation and navigation. The research shows that the post-Soviet period led to a dramatic change in Russian-Lithuanian economic relations; however, these relations retained potential for future development.

  3. Issues related to diagnosing oral lichen planus among oral pathologists in South India: A pilot survey.

    Science.gov (United States)

    Sanketh, D Sharathkumar; Srinivasan, Samuel Raj; Patil, Shankargouda; Ranganathan, Kannan

    2017-11-01

    In the present study, we simulated clinical scenarios by explicitly describing the history and clinical and histological features of hypothetical patients presenting with oral lichen planus (OLP), oral lichenoid lesion, and epithelial dysplasia in a self-designed questionnaire. By doing so, we aimed to elicit a diagnosis from oral pathologists and trainees, analyze their responses, appraise issues, and propose solutions regarding the diagnosis of OLP. The questionnaire was distributed to 100 oral pathologists and trainees in South India. Six questions were designed to assess awareness of the diagnostic aspects of OLP. Ten questions were hypothetical clinical scenarios (HCS) devised to evaluate respondents' knowledge of diagnostic guidelines and the criteria used by the respondents to render a diagnosis. There were 60 of 100 responses to the questionnaire. More than half the respondents were aware of the World Health Organization and modified guidelines of OLP. We observed considerable variations in diagnoses for the HCS. Our study illustrates the ambiguity in rendering an accurate diagnosis, despite adequate guidelines. Based on the responses for the HCS, we hypothesized that changes in the distribution (unilateral or bilateral) and clinical characteristic of OLP, and habits of patients, have a significant bearing on the clinical and final diagnoses of the lesion. © 2016 John Wiley & Sons Australia, Ltd.

  4. Radioactivity in books printed in Japan. Its source and relation to the year of issue

    International Nuclear Information System (INIS)

    Kobashi, Asaya

    1996-01-01

    The radioactivities of the naturally occurring radionuclides ( 226 Ra, 228 Ra, 228 Th and 40 K) and a fallout nuclide 137 Cs) in books produced in Japan in the 20th century were measured by gamma-ray spectrometry to obtain information on radiation emitted from books. The respective concentration ranges of 226 Ra, 228 Ra, 228 Th, 40 K, and 137 Cs were 0.2-6.4, 0.4-11.2, 0.3-11.3, 1-112, and 0-3.6 Bq kg -1 . X-ray diffraction spectra of the papers used in book printing showed that pyrophyllite, talc, kaolinite, and calcium carbonate were contained as fillers. A comparison of the radioactivity contents of the pulp and filler indicated that most of 226 Ra, 228 Ra, and 228 Th in the books was present in the filler whereas 137 Cs was in the pulp. The pattern of the concentration of each nuclide vs. the year of issue of the book was investigated. Patterns for the naturally occurring radionuclides were similar and were explained by the kinds of filler used. The pattern for 137 Cs differed from the patterns of the naturally occurring radionuclides, having a marked peak in the mid-1960s. (author)

  5. Secondary School Students' Knowledge and Opinions on Astrobiology Topics and Related Social Issues

    Science.gov (United States)

    Oreiro, Raquel; Solbes, Jordi

    2017-01-01

    Astrobiology is the study of the origin of life on Earth and the distribution of life in the Universe. Its multidisciplinary approach, social and philosophical implications, and appeal within the discipline and beyond make astrobiology a uniquely qualified subject for general science education. In this study, student knowledge and opinions on astrobiology topics were investigated. Eighty-nine students in their last year of compulsory education (age 15) completed a written questionnaire that consisted of 10 open questions on the topic of astrobiology. The results indicate that students have significant difficulties understanding the origin of life on Earth, despite exposure to the topic by way of the assigned textbooks. The students were often unaware of past or present achievements in the search for life within the Solar System and beyond, topics that are far less commonly seen in textbooks. Student questionnaire answers also indicated that students had problems in reasoning and critical thinking when asked for their opinions on issues such as the potential for life beyond Earth, the question of whether UFOs exist, or what our place is in the Universe. Astrobiology might help initiate student awareness as to current thinking on these matters and should be considered for general science education.

  6. Addressing Practical Issues Related Tto Nursing Care For International Visitors To Hiroshima

    Directory of Open Access Journals (Sweden)

    Mariko Nishikawa

    2014-04-01

    Full Text Available When nine million foreigners visited Japan in 2013, the federal government set a goal to attract an additional two and a half million visitors including medical tourists by 2020. This research investigates the attitudes and concerns of Japanese nurses when they are in a situation dealing with foreign patients. The data were collected from March through September 2010, from 114 nurses at three hospitals, in close proximity to popular tourist destinations in Hiroshima. A questionnaire was developed for this research, named Mari Meter, which included a section to write answers to an open question for the nurses to express their opinions. These responses were examined statistically and by word analysis using Text Mining Studio. Japanese nurses expressed greatest concern about payment options, foreign language skills, and issues of informed consent, when dealing with foreigners. The results confirm that, in order to provide a high quality of patient care, extra preparation and a greater knowledge of international workers and visitors are required by nursing professionals in Japan.

  7. Integrity, standards, and QC-related issues with big data in pre-clinical drug discovery.

    Science.gov (United States)

    Brothers, John F; Ung, Matthew; Escalante-Chong, Renan; Ross, Jermaine; Zhang, Jenny; Cha, Yoonjeong; Lysaght, Andrew; Funt, Jason; Kusko, Rebecca

    2018-06-01

    The tremendous expansion of data analytics and public and private big datasets presents an important opportunity for pre-clinical drug discovery and development. In the field of life sciences, the growth of genetic, genomic, transcriptomic and proteomic data is partly driven by a rapid decline in experimental costs as biotechnology improves throughput, scalability, and speed. Yet far too many researchers tend to underestimate the challenges and consequences involving data integrity and quality standards. Given the effect of data integrity on scientific interpretation, these issues have significant implications during preclinical drug development. We describe standardized approaches for maximizing the utility of publicly available or privately generated biological data and address some of the common pitfalls. We also discuss the increasing interest to integrate and interpret cross-platform data. Principles outlined here should serve as a useful broad guide for existing analytical practices and pipelines and as a tool for developing additional insights into therapeutics using big data. Copyright © 2018 Elsevier Inc. All rights reserved.

  8. Management issues related to effectively implementing a nutrition education program using peer educators.

    Science.gov (United States)

    Taylor, T; Serrano, E; Anderson, J

    2001-01-01

    To explore the influence of administrative aspects of a nutrition education program with peer educators delivering the program. Telephone interviews with peer educators trained to deliver La Cocina Saludable, a nutrition education program for Hispanics. Open- and closed-ended questions. Abuelas (grandmothers) recruited and trained as peer educators for the program. The sample included peer educators no longer teaching (22%), currently teaching (30%), and who never taught after training. Motives and incentives for becoming peer educators, challenges for peer educators, and reasons peer educators withdrew from the program. Descriptive statistics were used to analyze quantitative data from the closed-ended questions. Qualitative analysis was applied to data from open-ended questions. Working with community and learning about nutrition were prime motivators. Recruiting participants and coordination of classes appeared to be major challenges. Personal issues and traveling in a large geographic area were cited as the main reasons for quitting. The effectiveness of using peer educators for La Cocina Saludable may be improved through empowerment, additional training, a structured and equitable reimbursement system, and assistance to carry out administrative tasks.

  9. A Categorical Content Analysis of Highly Cited Literature Related to Trends and Issues in Special Education.

    Science.gov (United States)

    Arden, Sarah V; Pentimonti, Jill M; Cooray, Rochana; Jackson, Stephanie

    2017-07-01

    This investigation employs categorical content analysis processes as a mechanism to examine trends and issues in a sampling of highly cited (100+) literature in special education journals. The authors had two goals: (a) broadly identifying trends across publication type, content area, and methodology and (b) specifically identifying articles with disaggregated outcomes for students with learning disabilities (LD). Content analyses were conducted across highly cited (100+) articles published during a 20-year period (1992-2013) in a sample ( n = 3) of journals focused primarily on LD, and in one broad, cross-categorical journal recognized for its impact in the field. Results indicated trends in the article type (i.e., commentary and position papers), content (i.e., reading and behavior), and methodology (i.e., small proportions of experimental and quasi-experimental designs). Results also revealed stability in the proportion of intervention research studies when compared to previous analyses and a decline in the proportion of those that disaggregated data specifically for students with LD.

  10. A Review of Issues Related to Data Acquisition and Analysis in EEG/MEG Studies.

    Science.gov (United States)

    Puce, Aina; Hämäläinen, Matti S

    2017-05-31

    Electroencephalography (EEG) and magnetoencephalography (MEG) are non-invasive electrophysiological methods, which record electric potentials and magnetic fields due to electric currents in synchronously-active neurons. With MEG being more sensitive to neural activity from tangential currents and EEG being able to detect both radial and tangential sources, the two methods are complementary. Over the years, neurophysiological studies have changed considerably: high-density recordings are becoming de rigueur; there is interest in both spontaneous and evoked activity; and sophisticated artifact detection and removal methods are available. Improved head models for source estimation have also increased the precision of the current estimates, particularly for EEG and combined EEG/MEG. Because of their complementarity, more investigators are beginning to perform simultaneous EEG/MEG studies to gain more complete information about neural activity. Given the increase in methodological complexity in EEG/MEG, it is important to gather data that are of high quality and that are as artifact free as possible. Here, we discuss some issues in data acquisition and analysis of EEG and MEG data. Practical considerations for different types of EEG and MEG studies are also discussed.

  11. A Review of Issues Related to Data Acquisition and Analysis in EEG/MEG Studies

    Directory of Open Access Journals (Sweden)

    Aina Puce

    2017-05-01

    Full Text Available Electroencephalography (EEG and magnetoencephalography (MEG are non-invasive electrophysiological methods, which record electric potentials and magnetic fields due to electric currents in synchronously-active neurons. With MEG being more sensitive to neural activity from tangential currents and EEG being able to detect both radial and tangential sources, the two methods are complementary. Over the years, neurophysiological studies have changed considerably: high-density recordings are becoming de rigueur; there is interest in both spontaneous and evoked activity; and sophisticated artifact detection and removal methods are available. Improved head models for source estimation have also increased the precision of the current estimates, particularly for EEG and combined EEG/MEG. Because of their complementarity, more investigators are beginning to perform simultaneous EEG/MEG studies to gain more complete information about neural activity. Given the increase in methodological complexity in EEG/MEG, it is important to gather data that are of high quality and that are as artifact free as possible. Here, we discuss some issues in data acquisition and analysis of EEG and MEG data. Practical considerations for different types of EEG and MEG studies are also discussed.

  12. Management of pregnancy-related issues in multiple sclerosis patients: the need for an interdisciplinary approach.

    Science.gov (United States)

    Amato, Maria Pia; Bertolotto, Antonio; Brunelli, Roberto; Cavalla, Paola; Goretti, Benedetta; Marrosu, Maria Giovanna; Patti, Francesco; Pozzilli, Carlo; Provinciali, Leandro; Rizzo, Nicola; Strobelt, Nicola; Tedeschi, Gioacchino; Trojano, Maria; Comi, Giancarlo

    2017-10-01

    Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system (CNS), most probably autoimmune in origin, usually occurring in young adults with a female/male prevalence of approximately 3:1. Women with MS in the reproductive age may face challenging issues in reconciling the desire for parenthood with their condition, owing to the possible influence both on the ongoing or planned treatment with the possible consequences on the disease course and on the potential negative effects of treatments on foetal and pregnancy outcomes. At MS diagnosis, timely counselling should promote informed parenthood, while disease evolution should be assessed before making therapeutic decisions. Current guidelines advise the discontinuation of any treatment during pregnancy, with possible exceptions for some treatments in patients with very active disease. Relapses decline during pregnancy but are more frequent during puerperium, when MS therapy should be promptly resumed in most of the cases. First-line immunomodulatory agents, such as interferon-β (IFN-β) and glatiramer acetate (GA), significantly reduce the post-partum risk of relapse. Due to substantial evidence of safety with the use of GA during pregnancy, a recent change in European marketing authorization removed the pregnancy contraindication for GA. This paper reports a consensus of Italian experts involved in MS management, including neurologists, gynaecologists and psychologists. This consensus, based on a review of the available scientific evidence, promoted an interdisciplinary approach to the management of pregnancy in MS women.

  13. Scientific and ethical issues related to deep brain stimulation for disorders of mood, behavior, and thought.

    Science.gov (United States)

    Rabins, Peter; Appleby, Brian S; Brandt, Jason; DeLong, Mahlon R; Dunn, Laura B; Gabriëls, Loes; Greenberg, Benjamin D; Haber, Suzanne N; Holtzheimer, Paul E; Mari, Zoltan; Mayberg, Helen S; McCann, Evelyn; Mink, Sallie P; Rasmussen, Steven; Schlaepfer, Thomas E; Vawter, Dorothy E; Vitek, Jerrold L; Walkup, John; Mathews, Debra J H

    2009-09-01

    A 2-day consensus conference was held to examine scientific and ethical issues in the application of deep brain stimulation for treating mood and behavioral disorders, such as major depression, obsessive-compulsive disorder, and Tourette syndrome. The primary objectives of the conference were to (1) establish consensus among participants about the design of future clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and (2) develop standards for the protection of human subjects participating in such studies. Conference participants identified 16 key points for guiding research in this growing field. The adoption of the described guidelines would help to protect the safety and rights of research subjects who participate in clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and have further potential to benefit other stakeholders in the research process, including clinical researchers and device manufactures. That said, the adoption of the guidelines will require broad and substantial commitment from many of these same stakeholders.

  14. Rethinking the costs related to global warming. A survey of the issues

    International Nuclear Information System (INIS)

    Ekins, P.

    1995-01-01

    One approach to the economic analysis of global warming seeks to balance the costs of damage from or adaptation to it with the costs of mitigating it. The costs of adaptation and damage have been estimated using techniques of environmental evaluation, but are subject to a wide margin of uncertainty. The costs of mitigation, principally by reducing the emissions of CO 2 , have been estimated using different kinds of economic models, some of the results of which have suggested that very little abatement of carbon emissions is justified before the costs of abatement exceed the benefits of it in terms of foregone damage and adaptation costs. The paper analyses the extent to which this conclusion is a function of the modelling assumptions and techniques used, rather than likely practical outcomes, with regard to the models' treatment of unemployed resources, revenue recycling, prior distortions in the economy due to the tax system and possible dynamic effects from the introduction of a carbon-energy tax. It concludes that, with different and arguably more appropriate treatment of the above issues, especially when the secondary benefits of reducing CO 2 emissions are also taken into account, it is not clear that even substantial reductions in the use of fossil fuels will incur net costs, especially if there is the prospect of even moderate costs from global warming. 4 figs., 8 tabs., 95 refs

  15. Relation between film character and wafer alignment: critical alignment issues on HV device for VLSI manufacturing

    Science.gov (United States)

    Lo, Yi-Chuan; Lee, Chih-Hsiung; Lin, Hsun-Peng; Peng, Chiou-Shian

    1998-06-01

    Several continuous splits for wafer alignment target topography conditions to improve epitaxy film alignment were applied. The alignment evaluation among former layer pad oxide thickness (250 angstrom - 500 angstrom), drive oxide thickness (6000 angstrom - 10000 angstrom), nitride film thickness (600 angstrom - 1500 angstrom), initial oxide etch (fully wet etch, fully dry etch and dry plus wet etch) will be split to this experiment. Also various epitaxy deposition recipe such as: epitaxy source (SiHCl2 or SiCHCl3) and growth rate (1.3 micrometer/min approximately 2.0 micrometer/min) will be used to optimize the process window for alignment issue. All the reflectance signal and cross section photography of alignment target during NIKON stepper alignment process will be examined. Experimental results show epitaxy recipe plays an important role to wafer alignment. Low growth rate with good performance conformity epitaxy lead to alignment target avoid washout, pattern shift and distortion. All the results (signal monitor and film character) combined with NIKON's stepper standard laser scanning alignment system will be discussed in this paper.

  16. Practical issues relating to soil column chromatography for sorption parameter determination.

    Science.gov (United States)

    Bi, Erping; Schmidt, Torsten C; Haderlein, Stefan B

    2010-08-01

    Determination of sorption distribution coefficients (K(d)) of organic compounds by a dynamic soil column chromatography (SCC) method was developed and validated. Eurosoil 4, quartz, and alumina were chosen as exemplary packing materials. Heterocyclic aromatic compounds were selected in the validation of SCC. The prerequisites of SCC with regard to column dimension, packing procedure, and sample injection volume are discussed. Reproducible soil column packing was achieved by addition of a pre-column and an HPLC pump for subsequent compression of the packed material. Various methods to determine retention times from breakthrough curves are discussed and the use of the half mass method is recommended. To dilute soil with inert material can prevent column-clogging and help to complete experiments in a reasonable period of time. For the chosen probe compounds, quartz rather than alumina proved a suitable dilution material. Non-equilibrium issue can be overcome by conducting the experiments under different flowrates and/or performing numerical simulation. Copyright 2010 Elsevier Ltd. All rights reserved.

  17. ASTRID SFR prototype steam generator design evolution related to safety and cost issues - 15236

    International Nuclear Information System (INIS)

    Woaye Hune, A.; Gerber, A.; Pirus, J.P.; Soucille, L.; Rodriguez, G.; Beauchamp, F.

    2015-01-01

    One option of the ASTRID prototype power conversion systems (PCS) is the steam cycle based on the Rankine cycle, which has been implemented in the past in France in the Phenix and Superphenix Sodium Fast Reactors, and is also being implemented in other SFRs in construction in the world (Russia, India, China). This paper is placed in the context of the Rankine cycle ameliorations and in particular on the Steam Generator (SG), developed by AREVA, from the safety point of view without significant penalty on cost. Therefore significant progresses are expected to reduce sodium/water reaction accident scenario impact as much by prevention as by mitigation. ASTRID project performed a thorough comparison of SG designs with regard to these safety requirements but also including increased sodium/water segregation (inlet and outlet of sodium implemented at the bottom of the SG), material issues and cost considerations. The design is based today on a monolithic SG with alloy 800 helical tubes but equipped with geometric specificities necessary for allowing the use of a single component per secondary loop. (authors)

  18. Accelerator-based conversion (ABC) of weapons plutonium: Plant layout study and related design issues

    International Nuclear Information System (INIS)

    Cowell, B.S.; Fontana, M.H.; Krakowski, R.A.; Beard, C.A.; Buksa, J.J.; Davidson, J.W.; Sailor, W.C.; Williamson, M.A.

    1995-01-01

    In preparation for and in support of a detailed R and D Plan for the Accelerator-Based Conversion (ABC) of weapons plutonium, an ABC Plant Layout Study was conducted at the level of a pre-conceptual engineering design. The plant layout is based on an adaptation of the Molten-Salt Breeder Reactor (MSBR) detailed conceptual design that was completed in the early 1070s. Although the ABC Plant Layout Study included the Accelerator Equipment as an essential element, the engineering assessment focused primarily on the Target; Primary System (blanket and all systems containing plutonium-bearing fuel salt); the Heat-Removal System (secondary-coolant-salt and supercritical-steam systems); Chemical Processing; Operation and Maintenance; Containment and Safety; and Instrumentation and Control systems. Although constrained primarily to a reflection of an accelerator-driven (subcritical) variant of MSBR system, unique features and added flexibilities of the ABC suggest improved or alternative approaches to each of the above-listed subsystems; these, along with the key technical issues in need of resolution through a detailed R ampersand D plan for ABC are described on the bases of the ''strawman'' or ''point-of-departure'' plant layout that resulted from this study

  19. Secondary School Students' Knowledge and Opinions on Astrobiology Topics and Related Social Issues.

    Science.gov (United States)

    Oreiro, Raquel; Solbes, Jordi

    2017-01-01

    Astrobiology is the study of the origin of life on Earth and the distribution of life in the Universe. Its multidisciplinary approach, social and philosophical implications, and appeal within the discipline and beyond make astrobiology a uniquely qualified subject for general science education. In this study, student knowledge and opinions on astrobiology topics were investigated. Eighty-nine students in their last year of compulsory education (age 15) completed a written questionnaire that consisted of 10 open questions on the topic of astrobiology. The results indicate that students have significant difficulties understanding the origin of life on Earth, despite exposure to the topic by way of the assigned textbooks. The students were often unaware of past or present achievements in the search for life within the Solar System and beyond, topics that are far less commonly seen in textbooks. Student questionnaire answers also indicated that students had problems in reasoning and critical thinking when asked for their opinions on issues such as the potential for life beyond Earth, the question of whether UFOs exist, or what our place is in the Universe. Astrobiology might help initiate student awareness as to current thinking on these matters and should be considered for general science education. Key Words: Astrobiology-Students' views-Science education. Astrobiology 17, 91-99.

  20. Indoor air quality issues related to the acquisition of conservation in commercial buildings

    Energy Technology Data Exchange (ETDEWEB)

    Baechler, M.C.; Hadley, D.L.; Marseille, T.J.

    1990-09-01

    The quality of indoor air in commercial buildings is dependent on the complex interaction between sources of indoor pollutants, environmental factors within buildings such as temperature and humidity, the removal of air pollutants by air-cleaning devices, and the removal and dilution of pollutants from outside air. To the extent that energy conservation measures (ECMs) may affect a number of these factors, the relationship between ECMs and indoor air quality is difficult to predict. Energy conservation measures may affect pollutant levels in other ways. Conservation measures, such as caulking and insulation, may introduce sources of indoor pollutants. Measures that reduce mechanical ventilation may allow pollutants to build up inside structures. Finally, heating, ventilation, and air-conditioning (HVAC) systems may provide surface areas for the growth of biogenic agents, or may encourage the dissemination of pollutants throughout a building. Information about indoor air quality and ventilation in both new and existing commercial buildings is summarized in this report. Sick building syndrome and specific pollutants are discussed, as are broader issues such as ventilation, general mitigation techniques, and the interaction between energy conservation activities and indoor air quality. Pacific Northwest Laboratory (PNL) prepared this review to aid the Bonneville Power Administration (Bonneville) in its assessment of potential environmental effects resulting from conservation activities in commercial buildings. 76 refs., 2 figs., 19 tabs.

  1. Disruption of adherens junction and alterations in YAP-related proliferation behavior as part of the underlying cell transformation process of alcohol-induced oral carcinogenesis.

    Science.gov (United States)

    Husari, Ayman; Hülter-Hassler, Diana; Steinberg, Thorsten; Schulz, Simon Daniel; Tomakidi, Pascal

    2018-01-01

    Accumulating evidences indicate that alcohol might play a causative in oral cancer. Unfortunately, in vitro cell systems, uncovering the molecular background of the underlying cell transformation process, are rare. Therefore, this study was conducted, to identify molecular changes and characterize their putative cell behavioral consequences in epitheloid (EPI) and fibroblastoid (FIB) oral keratinocyte phenotypes, arising from chronical alcohol treatment. Concerning adherens junctions (AJs), both EPI and FIB showed membrane-bound β-catenin, but exhibited differences for E-cadherin and zyxin. While EPI revealed E-cadherin/β-catenin membrane co-localization, which in parts also applied for zyxin, FIB membranes were devoid of E-cadherin and exhibited marginal zyxin expression. Fetal calf serum (FCS) administration in starved cells promoted proliferation in both keratinocyte phenotypes, whereat EPI and FIB yielded a strikingly modified FCS sensitivity on the temporal scale. Impedance measurement-based cell index detection yielded proliferation stimulation occurring much earlier in FIB (45h). Nuclear preference of the proliferation-associated YAP co-transcription factor in FIB was FCS independent, while it required FCS in EPI. Taken together, the lack of membrane-inherent E-cadherin/β-catenin co-localization together with low zyxin - reveals perturbation of AJ integrity in FIB. Regarding cell behavior, perturbed AJs in FIB correlate with temporal proliferation sensitivity towards FCS. CYF of 5.6 strongly suggests involvement of chromatin-bound YAP in FIB's proliferation temperosensitivity. These molecular differences detected for EPI and FIB are part of the underlying cell transformation process of alcohol-induced oral carcinogenesis, and indicate FIB being in a more advanced transformation stage. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Sodium arsenite-induced inhibition of cell proliferation is related to inhibition of IL-2 mRNA expression in mouse activated T cells

    Energy Technology Data Exchange (ETDEWEB)

    Conde, Patricia; Acosta-Saavedra, Leonor C.; Calderon-Aranda, Emma S. [Centro de Investigacion y de Estudios Avanzados, CINVESTAV, Seccion Toxicologia, P.O. Box 14-740, Mexico, D.F. (Mexico); Goytia-Acevedo, Raquel C. [Universidad Juarez del Estado de Durango, Facultad de Medicina, Gomez Palacio, Durango (Mexico)

    2007-04-15

    A proposed mechanism for the As-induced inhibition of cell proliferation is the inhibition of IL-2 secretion. However, the effects of arsenite on IL-2 mRNA expression or on the ERK pathway in activated-T cells have not yet been described. We examined the effect of arsenite on IL-2 mRNA expression, cell activation and proliferation in PHA-stimulated murine lymphocytes. Arsenite (1 and 10 {mu}M) decreased IL-2 mRNA expression, IL-2 secretion and cell proliferation. Arsenite (10 {mu}M) strongly inhibited ERK-phosphorylation. However, the partial inhibition (50%) of IL-2 mRNA produced by 1 {mu}M, consistent with the effects on IL-2 secretion and cell proliferation, could not be explained by the inhibition of ERK-phosphorylation, which was not affected at this concentration. The inhibition of IL-2 mRNA expression caused by 1 {mu}M could be associated to effects on pathways located downstream or parallel to ERK. Arsenite also decreased early activation (surface CD69{sup +} expression) in both CD4{sup +} and CD8{sup +}, and decreased total CD8{sup +} count without significantly affecting CD4{sup +}, supporting that the cellular immune response mediated by cytotoxic T cells is an arsenic target. Thus, our results suggest that arsenite decreases IL-2 mRNA levels and T-cell activation and proliferation. However, further studies on the effects of arsenite on IL-2 gene transcription and IL-2 mRNA stability are needed. (orig.)

  3. Relative efficacy of drugs: an emerging issue between regulatory agencies and third-party payers.

    Science.gov (United States)

    Eichler, Hans-Georg; Bloechl-Daum, Brigitte; Abadie, Eric; Barnett, David; König, Franz; Pearson, Steven

    2010-04-01

    Drug regulatory agencies have traditionally assessed the quality, safety and efficacy of drugs, and the current paradigm dictates that a new drug should be licensed when the benefits outweigh the risks. By contrast, third-party payers base their reimbursement decisions predominantly on the health benefits of the drug relative to existing treatment options (termed relative efficacy; RE). Over the past decade, the role of payers has become more prominent, and time-to-market no longer means time-to-licensing but time-to-reimbursement. Companies now have to satisfy the sometimes divergent needs of both regulators and payers, and to address RE during the pre-marketing stages. This article describes the current political background to the RE debate and presents the scientific and methodological challenges as they relate to RE assessment. In addition, we explain the impact of RE on drug development, and speculate on future developments and actions that are likely to be required from key players.

  4. Some issues in the simulation of two-phase flows: The relative velocity

    International Nuclear Information System (INIS)

    Gräbel, J.; Hensel, S.; Ueberholz, P.; Farber, P.; Zeidan, D.

    2016-01-01

    In this paper we compare numerical approximations for solving the Riemann problem for a hyperbolic two-phase flow model in two-dimensional space. The model is based on mixture parameters of state where the relative velocity between the two-phase systems is taken into account. This relative velocity appears as a main discontinuous flow variable through the complete wave structure and cannot be recovered correctly by some numerical techniques when simulating the associated Riemann problem. Simulations are validated by comparing the results of the numerical calculation qualitatively with OpenFOAM software. Simulations also indicate that OpenFOAM is unable to resolve the relative velocity associated with the Riemann problem.

  5. Some issues in the simulation of two-phase flows: The relative velocity

    Energy Technology Data Exchange (ETDEWEB)

    Gräbel, J.; Hensel, S.; Ueberholz, P.; Farber, P. [Niederrhein University of Applied Sciences, Institute for Modelling and High Performance Computing, Reinarzstraße 49, 47805 Krefeld (Germany); Zeidan, D. [School of Basic Sciences and Humanities, German Jordanian University, Amman (Jordan)

    2016-06-08

    In this paper we compare numerical approximations for solving the Riemann problem for a hyperbolic two-phase flow model in two-dimensional space. The model is based on mixture parameters of state where the relative velocity between the two-phase systems is taken into account. This relative velocity appears as a main discontinuous flow variable through the complete wave structure and cannot be recovered correctly by some numerical techniques when simulating the associated Riemann problem. Simulations are validated by comparing the results of the numerical calculation qualitatively with OpenFOAM software. Simulations also indicate that OpenFOAM is unable to resolve the relative velocity associated with the Riemann problem.

  6. Problems and Issues in Higher Education: Perspectives on Iran-United States Educational Relations and Influences.

    Science.gov (United States)

    Fereshteh, M. Hussein

    This review evaluates the writings and opinions of Americans and Iranians on relations and influences between institutions of higher education in Iran and the United States before and after the 1979 revolution. The review explores the arrival of modern western education in Iran, Egypt, and Turkey where a traditional education system had prevailed…

  7. A psychology literature study on modality related issues for multimodal presentation in crisis management

    NARCIS (Netherlands)

    Cao, Y.

    2008-01-01

    The motivation of this psychology literature study is to obtain modality related guidelines for real-time information presentation in crisis management environment. The crisis management task is usually companied by time urgency, risk, uncertainty, and high information density. Decision makers

  8. Key Issues in the United States-Iranian Relations 1980 – 2012 ...

    African Journals Online (AJOL)

    In the views of Palmer and Perkins, (2007) “these are times that try men's souls”. The statement corroborates the America relations with Iran since the mid-1980s, when the United States, Israel and other Western Powers started accusing Iran of Uranium enrichment toward pursuing a nuclear weapons capability, a situation ...

  9. Advice about Work-Related Issues to Peers and Employers from Head and Neck Cancer Survivors

    NARCIS (Netherlands)

    Dewa, Carolyn S.; Trojanowski, Lucy; Tamminga, Sietske J.; Ringash, Jolie; McQuestion, Maurene; Hoch, Jeffrey S.

    2016-01-01

    The purpose of this exploratory and descriptive study is to contribute to the sparse return-to-work literature on head and neck cancer (HNC) survivors. Interview participants were asked to reflect upon their work-related experience with cancer by answering two specific questions: (1) What advice

  10. ISSUES RELATED TO THE ACCOUNTING TREATMENT OF THE TANGIBLE AND INTANGIBLE ASSETS DEPRECIATION

    Directory of Open Access Journals (Sweden)

    Danciu Radu

    2011-12-01

    Full Text Available The issue of accounting depreciation is an older concern of this study's authors on the incidence over the true and fair view of the earning and the net value of the non- current assets. Proceeding from the consideration that the present depreciation methods, acknowleged by the accounting standards and regulations are not sufficient to render the reality of the irreversible impairment of the fixed assets nor that of the material and immaterial investment recovery we performed a research on the indicators reported by 20 companies in Cluj county and we applied a questionnaire to each entity on the depreciation methods used, their incidence on the true and fair view and their proposals for the completion of the depreciation methods. The objective of the research is to identify the most appropriate depreciation methods, truthfully illustrating the effects of the irreversible impairment on the net asset and on the earning, to introduce the excluded assests in the cathegory of the non-current assets ( like property and plant, goodwill, intangible assets created with ones own strengths and the enforcement of appropriate treatments to the revaluation differences and their own overhead investments. The International Accounting Standard IAS 16 - Property, plant and equipment refers to three depreciation methods: the straightline method, the diminishing balance method and the technical depreciation method (units of production method. In Romania only two of these methods are accepted: the straightline method, the diminishing balance method and the accelerated method was additionally instilled, which is used internationally in exceptional situations and not currently. The results of the research led us to the following conclusions: - for the depreciation of the machinery, facilities and technological equipments it is recommended to use the technical depreciation method or the units of production method; -taking into consideration the financial conception on

  11. Comparative analysis of proliferation resistance assessment methodologies

    International Nuclear Information System (INIS)

    Takaki, Naoyuki; Kikuchi, Masahiro; Inoue, Naoko; Osabe, Takeshi

    2005-01-01

    Comparative analysis of the methodologies was performed based on the discussions in the international workshop on 'Assessment Methodology of Proliferation Resistance for Future Nuclear Energy Systems' held in Tokyo, on March 2005. Through the workshop and succeeding considerations, it is clarified that the proliferation resistance assessment methodologies are affected by the broader nuclear options being pursued and also by the political situations of the state. Even the definition of proliferation resistance, despite the commonality of fundamental issues, derives from perceived threat and implementation circumstances inherent to the larger programs. Deep recognitions of the 'difference' among communities would help us to make further essential and progressed discussion with harmonization. (author)

  12. Peroxisome proliferator-activated receptor γ controls ingestive behavior, agouti-related protein, and neuropeptide Y mRNA in the arcuate hypothalamus.

    Science.gov (United States)

    Garretson, John T; Teubner, Brett J W; Grove, Kevin L; Vazdarjanova, Almira; Ryu, Vitaly; Bartness, Timothy J

    2015-03-18

    Peroxisome proliferator-activated receptor γ (PPARγ) is clinically targeted for type II diabetes treatment; however, rosiglitazone (ROSI), a PPARγ agonist, increases food intake and body/fat mass as side-effects. Mechanisms for these effects and the role of PPARγ in feeding are not understood. Therefore, we tested this role in Siberian hamsters, a model of human energy balance, and C57BL/6 mice. We tested the following: (1) how ROSI and/or GW9662 (2-chloro-5-nitro-N-phenylbenzamide; PPARγ antagonist) injected intraperitoneally or into the third ventricle (3V) affected Siberian hamster feeding behaviors; (2) whether food deprivation (FD) co-increases agouti-related protein (AgRP) and PPARγ mRNA expression in Siberian hamsters and mice; (3) whether intraperitoneally administered ROSI increases AgRP and NPY in ad libitum-fed animals; (4) whether intraperitoneally administered PPARγ antagonism blocks FD-induced increases in AgRP and NPY; and finally, (5) whether intraperitoneally administered PPARγ modulation affects plasma ghrelin. Third ventricular and intraperitoneally administered ROSI increased food hoarding and intake for 7 d, an effect attenuated by 3V GW9662, and also prevented (intraperitoneal) FD-induced feeding. FD hamsters and mice increased AgRP within the arcuate hypothalamic nucleus with concomitant increases in PPARγ exclusively within AgRP/NPY neurons. ROSI increased AgRP and NPY similarly to FD, and GW9662 prevented FD-induced increases in AgRP and NPY in both species. Neither ROSI nor GW9662 affected plasma ghrelin. Thus, we demonstrated that PPARγ activation is sufficient to trigger food hoarding/intake, increase AgRP/NPY, and possibly is necessary for FD-induced increases in feeding and AgRP/NPY. These findings provide initial evidence that FD-induced increases in AgRP/NPY may be a direct PPARγ-dependent process that controls ingestive behaviors. Copyright © 2015 the authors 0270-6474/15/354571-11$15.00/0.

  13. Legal aspects of work related stress in nursing. Exploring the issues.

    Science.gov (United States)

    Abu al Rub, R

    2000-03-01

    Nurses are under a great deal of distress related to a variety of work stressors. Work related stress jeopardizes the mental and physical well being of nurses, as well as the quality of care provided for clients. The Occupational Safety and Health Act of 1970 holds employers responsible for the mental and physical well being of their employees. However, the regulations are not always straightforward concerning compensation claims for mental disabilities due to work stress. Recovery of claims is possible if standards (i.e., personal injury, causal relationship between injury and employment) are met. Requirements for recovery of physical/mental and mental/physical claims are agreed on by most states, whereas mental/mental claims are controversial among states and courts. Nurses can monitor and influence legislation to create requirements to encourage employers to develop preventive approaches to reducing work induced stress.

  14. Climate and climate-related issues for the safety assessment SR-Site

    Energy Technology Data Exchange (ETDEWEB)

    2010-12-15

    The purpose of this report is to document current scientific knowledge on climate and climate-related conditions, relevant to the long-term safety of a KBS-3 repository, to a level required for an adequate treatment in the safety assessment SR-Site. The report also presents a number of dedicated studies on climate and selected climate-related processes of relevance for the assessment of long term repository safety. Based on this information, the report presents a number of possible future climate developments for Forsmark, the site selected for building a repository for spent nuclear fuel in Sweden (Figure 1-1). The presented climate developments are used as basis for the selection and analysis of SR-Site safety assessment scenarios in the SR-Site main report /SKB 2011/. The present report is based on research conducted and published by SKB as well as on research reported in the general scientific literature

  15. Topical issues of psychological research materials on matters related to extremism

    Directory of Open Access Journals (Sweden)

    Sekerazh T.N.

    2014-12-01

    Full Text Available The article deals with methodological support psychological and linguistic research "extremist" materials. Presents a comprehensive psycho-linguistic approach to the examination of information materials on matters related to combating extremism and terrorism, and certain provisions of the methodology developed by the Russian federal center of judicial examination of the Ministry of Justice of the Russian Federation. Based on the analysis of the "verbal" crimes related to criminal legal interpretation of extremism and terrorism, highlighted the types of prohibited public expression of communicative action, corresponding to the seven types of "extremist" values. The article outlines the key features of psychological analysis "extremist" materials research stages. It is shown that the complex (psycho-linguistic approach to the study of materials of extremist orientation, is scientifically sound, methodically proven, appropriate to the needs of law enforcement, judicial and investigative practice.

  16. Climate and climate-related issues for the safety assessment SR-Site

    International Nuclear Information System (INIS)

    2010-12-01

    The purpose of this report is to document current scientific knowledge on climate and climate-related conditions, relevant to the long-term safety of a KBS-3 repository, to a level required for an adequate treatment in the safety assessment SR-Site. The report also presents a number of dedicated studies on climate and selected climate-related processes of relevance for the assessment of long term repository safety. Based on this information, the report presents a number of possible future climate developments for Forsmark, the site selected for building a repository for spent nuclear fuel in Sweden (Figure 1-1). The presented climate developments are used as basis for the selection and analysis of SR-Site safety assessment scenarios in the SR-Site main report /SKB 2011/. The present report is based on research conducted and published by SKB as well as on research reported in the general scientific literature

  17. 2. International conference on non-proliferation problems. Abstracts of reports

    Energy Technology Data Exchange (ETDEWEB)

    Koltysheva, G I; Perepelkin, I G [eds.

    1999-12-31

    On 14-17 September 1998, in Kurchatov (Kazakstan), II. International Conference on Non-proliferation Problems was held. Representatives from different international organizations (IAEA, UNO, CTBT Organization Preparatory Committee, Austria), from organizations of Kazakstan, Russia, USA, Japan took part in the Conference. At the conference there were 220 participants. Different issues relating to non-proliferation were discussed at the conference sections. The Conference included Plenary Session `History and Current State of Non-proliferation Problem` and three sections: (1) Practical measures to support non-proliferation regime and Control for Nuclear Tests`; (2) Problems on Eliminating Nuclear tests Consequences and Conversion of Nuclear and Industrial Complex`; (3) Medical and ecological problems of Nuclear Tests Consequences`

  18. Nuclear proliferation and terrorism in the post-9/11 world

    CERN Document Server

    Hafemeister, David

    2016-01-01

    This book fills a clear gap in the literature for a technically-focused book covering nuclear proliferation and related issues post-9/11. Using a concept-led approach which serves a broad readership, it provides detailed overview of nuclear weapons, nuclear proliferation and international nuclear policy. The author addresses topics including offensive and defensive missile systems, command and control, verification, weapon effects, and nuclear testing. A chronology of nuclear arms is presented including detailed discussion of the Cold War, proliferation, and arms control treaties. The book is tailored to courses on nuclear proliferation, and the general reader will also find it a fascinating introduction to the science and strategy behind international nuclear policy in the modern era. “Finally, a spritely, accessible overview of the nuclear world in historical context from someone who has both seen it from the U.S. State Department and Congressional policy trenches and taught it for 43 years. A gift to bot...

  19. 2. International conference on non-proliferation problems. Abstracts of reports

    International Nuclear Information System (INIS)

    Koltysheva, G.I.; Perepelkin, I.G.

    1998-01-01

    On 14-17 September 1998, in Kurchatov (Kazakstan), II. International Conference on Non-proliferation Problems was held. Representatives from different international organizations (IAEA, UNO, CTBT Organization Preparatory Committee, Austria), from organizations of Kazakstan, Russia, USA, Japan took part in the Conference. At the conference there were 220 participants. Different issues relating to non-proliferation were discussed at the conference sections. The Conference included Plenary Session 'History and Current State of Non-proliferation Problem' and three sections: 1) Practical measures to support non-proliferation regime and Control for Nuclear Tests'; 2) Problems on Eliminating Nuclear tests Consequences and Conversion of Nuclear and Industrial Complex'; 3) Medical and ecological problems of Nuclear Tests Consequences'

  20. Relational safety and liberating training spaces: an application with a focus on sexual orientation issues.

    Science.gov (United States)

    Hernández, Pilar; Rankin, Pressley

    2008-04-01

    This article describes and discusses a teaching case of a clinical training situation involving a gay marriage and family therapy student working with a same-sex affectional couple. The conceptual pillars of this teaching case, relational safety and liberating spaces, are advanced as illustrations of how the student developed his voice in the training process. Pivotal moments in this process are discussed, as are implications for training and personal and professional growth.

  1. Direct Investments in Croatia in the Form of Personal Companies – Tax Related Issues

    OpenAIRE

    Luketina, Marina

    2017-01-01

    The bilateral economic relations between Austria and Croatia are of prime importance to both countries: more than one quarter of foreign investments realised in Croatia stem from Austrian sources. Indeed, Austria is the largest investor in Croatia. Although the Croatian legal framework provides for several investment possibilities, Austrian residents prefer to invest in Croatian capital companies. However, especially from the perspective of Austrian residents, substantial tax benefits may res...

  2. Complexity Triggered by Economic Globalisation— The Issue of On-Line Betting-Related Match Fixing

    OpenAIRE

    Wladimir Andreff

    2017-01-01

    Complexity in mainstream economics consists in high intermediary consumption of mathematics. A new approach to complexity economics dwells upon path-dependent global systems; their emergence and evolving organisation. The focus here is on the complexity of the real economic world due to globalisation. On-line betting related match-fixing is a case in point about which the article presents non-exhaustive empirical evidence and shows how it is analysed with the standard model of the economics o...

  3. Health-related quality of life issues in women with polycystic ovary syndrome.

    Science.gov (United States)

    McCook, Judy Griffin; Reame, Nancy E; Thatcher, Samuel S

    2005-01-01

    To evaluate the influence of obesity, fertility status, and androgenism scores on health-related quality of life in women with polycystic ovary syndrome (PCOS). Cross-sectional, correlational. Private reproductive endocrinology practice in two southeast U.S. cities. Convenience sample of 128 women with PCOS, half of whom were attempting to conceive in addition to being treated for PCOS. Most were White (97%), married (78%), with a mean age of 30.4 years (SD +/- 5.5). The Health-Related Quality of Life Questionnaire (PCOSQ) for women with polycystic ovary syndrome. A laboratory panel and clinical measures, including body mass index, waist-to-hip ratio, and degree of hirsutism. The most common health-related quality of life concern reported by women with PCOS was weight, followed in descending order by menstrual problems, infertility, emotions, and body hair. The psychological implications of PCOS are easily underestimated and have been largely ignored. Nursing has a pivotal role in recognizing these concerns and implementing therapy to improve quality of life in women with PCOS.

  4. Some issues related to polarized radiative transfer in a multilayer medium with a changing index of refraction

    International Nuclear Information System (INIS)

    Garcia, R D M

    2012-01-01

    A couple of issues raised in a recent work on Fresnel boundary and interface conditions for polarized radiative transfer are discussed. The first issue concerns a normalization that has to be performed on the transmission matrix relating the transmitted and incident Stokes vectors at a smooth interface between different materials. It was found that the normalization step is not performed in a correct way in many existing works and so the effects of the two most frequent discrepancies encountered in these works are evaluated for a simple model of an atmosphere-water system. The second issue has to do with a choice of the sign of the parallel component of the amplitude coefficient of reflection R l when constructing the reflection matrix that relates the reflected and incident Stokes vectors at a smooth interface. A computational approach based on the limit to the case with constant index of refraction is used to determine the appropriate sign of R l for polarized radiative transfer calculations in multilayers with different indices of refraction.

  5. Conflict of law issues related to Switzerland's participation in the Paris Nuclear Third Party Liability Regime

    International Nuclear Information System (INIS)

    Waldner, Michael

    2012-01-01

    In spite of the active role Switzerland played during the negotiation process of the Paris Convention, it only recently ratified the Convention including all its amending Protocols. The whole Paris regime will become binding for Switzerland only upon entry into force of the Protocols of 2004. Concurrently, the Federal Council will put into force a revised Swiss Nuclear Liability Act and ratify the Joint Protocol. Being a party to the Paris regime and the Joint Protocol, Switzerland will be in treaty relationships with Paris states and with Vienna states which are party to the Joint Protocol. This paper assesses the legal protection of Swiss victims and the liability risks faced by Swiss operators and other potential defendants (such as suppliers and builders) under the new legal regime with a particular view to conflict of laws issues. For the purpose of this assessment the paper examines which courts will be competent to hear claims of Swiss victims and against Swiss defendants in different scenarios, which law these courts should apply, whether or not the principle of legal channelling will apply and what the applicable liability amounts are. The assessment shows an ambiguous picture: Swiss operators, suppliers and builders clearly benefit from a higher degree of legal certainty. While in the absence of treaty relationships Swiss operators could potentially be sued before any foreign court, there will now be only one court with jurisdiction over claims of victims of convention states; Swiss suppliers and builders for their part will be protected by the principle of legal channelling, which basically exempts them from any liability risk. Swiss victims will benefit from treaty-backed entitlement to compensation from foreign operators; also, the judgements rendered in their favour will be enforceable in the whole convention territory; however, the limitation of the operator's liability in many Paris and Vienna states, raises doubts about whether the available funds

  6. North America Wound, Ostomy, and Continence and Enterostomal Therapy Nurses Current Ostomy Care Practice Related to Peristomal Skin Issues.

    Science.gov (United States)

    Colwell, Janice C; McNichol, Laurie; Boarini, Joy

    The purpose of this study was to describe the practice of 796 ostomy nurses in North America in 2014 related to peristomal skin issues. Descriptive study. Participants were 796 wound, ostomy, and continence (WOC) and enterostomal therapy (ET) nurses currently practicing in the United States or Canada and caring for patients with ostomies. The collection of data occurred in conjunction with an educational program on peristomal skin complications and practice issues and solicited the participant's perception on the incidence and frequency of peristomal skin issues as well as on practice patterns. Participants attended an educational program. They were also asked to anonymously respond to multiple-choice questions on ostomy care management via an audience response system followed by discussion of each item and their responses. This descriptive study reports on the answers to the questions as well as the pertinent discussion points. Participants estimated that approximately 77.70% of their patients developed peristomal skin issues. The most commonly encountered problem was irritant contact dermatitis (peristomal moisture-associated skin damage). Contributing factors were inappropriate use of a pouching system owing to lack of follow-up after hospital discharge. Reported interventions for the prevention and management of peristomal skin issues included preoperative stoma site marking, use of a convex pouching system, and barrier rings. However, subsequent discussion revealed that the frequency of use of these products varied considerably. Participants identified shortened hospital stays, absence of preoperative stoma marking, and limited outpatient follow-up as contributing to development of peristomal skin problems. WOC and ET nurses estimate that more than three-quarters of persons living with an ostomy develop peristomal skin problems. Multiple interventions for managing these problems were identified, but some variability in management approaches emerged.

  7. Advice about Work-Related Issues to Peers and Employers from Head and Neck Cancer Survivors.

    Science.gov (United States)

    Dewa, Carolyn S; Trojanowski, Lucy; Tamminga, Sietske J; Ringash, Jolie; McQuestion, Maurene; Hoch, Jeffrey S

    2016-01-01

    The purpose of this exploratory and descriptive study is to contribute to the sparse return-to-work literature on head and neck cancer (HNC) survivors. Interview participants were asked to reflect upon their work-related experience with cancer by answering two specific questions: (1) What advice would you give someone who has been newly diagnosed with head and neck cancer? (2) What advice would you give to employers of these people? Data were gathered through 10 individual semi-structured in-depth interviews with HNC clinic patients at a regional cancer center's head and neck clinic in Ontario, Canada. A constant comparative method of theme development was used. Codes identified in and derived from the data were discussed by research team members until consensus was reached. Codes with similar characteristics were grouped together and used to develop overarching themes. Work-related advice for peers focused on personal self-care and interactions within workplaces. Work-related advice to employers focused on demonstrating basic human values as well as the importance of communication. The study results suggest HNC clinic patients should be proactive with employers and help to set reasonable expectations and provide a realistic plan for work to be successfully completed. HNC clinic patients should develop communication skills to effectively disclose their cancer and treatment to employers. In this exploratory study, HNC clinic patients' advice was solution-focused underscoring the importance of self-care and pro-active communication and planning with employers. Employers were advised to demonstrate core human values throughout all phases of the work disability episode beginning at diagnosis.

  8. Issues Related to Recruitment of Enlisted Personnel for the Reserve Components. Wave II. Technical Volume. Supplement.

    Science.gov (United States)

    1980-06-01

    in the military; atti- tudes toward feminism ; and other attitudes related to the need to be with others and feelings of control/ stability. -29...to play team sports than individual sports . l( ) 2( ) 3( ) 4( ) 5( ) -41e. Our country is too militaristic. 1( ) 2( ) 3( ) 4( ) 5( )-4 f. A nation...U( 2( ) 3( ) 4( X ()-L9 d, It’s more fun to play team sports than individual sports . () 2() 3() 4() 5( )-2 e. Our country is too militaristic. 1( ) 2

  9. The handbook of nuclear non-proliferation

    International Nuclear Information System (INIS)

    Yang, M. H.; Lee, B. W.; Oh, K. B.; Lee, H. M.; Ko, H. S.; Ryu, J. S.; Lee, K. S.

    2003-07-01

    This report analyzed international non-proliferation regime preventing from spread of nuclear weapon. This report took review from the historical background of non-proliferation regime to the recent changes and current status. It is here divided into multilateral and bilateral regime. First of all, this report dealt four multilateral treaties concluded for international non-proliferation such as NPT, NWFZ, CTBT and others. And international organization and regimes concerned with non-proliferation are also analyzed focused on UN, IAEA, ZC and NSG, regional safeguards system and international conferences. In addition, this report reviewed the nuclear cooperation agreement related with Korea which is a important tool for bilateral regime

  10. Talking about epilepsy: Challenges parents face when communicating with their child about epilepsy and epilepsy-related issues.

    Science.gov (United States)

    O'Toole, Stephanie; Lambert, Veronica; Gallagher, Pamela; Shahwan, Amre; Austin, Joan K

    2016-04-01

    The aim of this qualitative study was to explore the challenges that parents of children with epilepsy experienced when engaging in dialog with their child about epilepsy and epilepsy-related issues. Using a qualitative exploratory approach, interviews were conducted with 34 parents of children with epilepsy (aged 6-16 years), consisting of 27 mothers and 7 fathers. Data were transcribed verbatim and thematically analyzed. Findings revealed five main themes: normalizing epilepsy, the invisibility of epilepsy, information concealment, fear of misinforming the child, and difficulty in discussing particular epilepsy-related issues. Many of the communicative challenges experienced by parents impacted on their ability to engage openly in parent-child dialog about epilepsy in the home. Parents face specific challenges when choosing to communicate with their child about epilepsy, relating to creating a sense of normality, reducing fear of causing their child worry, and having a lack of epilepsy-related knowledge. Healthcare professionals who work closely with families living with epilepsy should remain mindful of the importance of discussing family communication surrounding epilepsy and the challenges parents of children with epilepsy face when talking about epilepsy within the home. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. India-Pakistan nuclear issues. Hearing before the Committee on Foreign Relations, United States Senate, Ninety-Sixth Congress, second session March 18, 1980

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    The proceedings of Hearings on nuclear issues between the US, India and Pakistan are included in this volume. The committee wants to explore with the administration precisely where matters stand with India and Pakistan on nuclear issues, what policy alternatives the administration may be considering with respect to those issues, and how the administration intends to relate its actions on nuclear matters to other US foreign policy issues

  12. Proliferation: myth or reality?

    International Nuclear Information System (INIS)

    2005-01-01

    This article analyzes the proliferation approach, its technical condition and political motivation, and the share between the myth (political deception, assumptions and extrapolations) and the reality of proliferation. Its appreciation is complicated by the irrational behaviour of some political actors and by the significant loss of the non-use taboo. The control of technologies is an important element for proliferation slowing down but an efficient and autonomous intelligence system remains indispensable. (J.S.)

  13. Expression of lysophosphatidic acid receptor 1 and relation with cell proliferation, apoptosis, and angiogenesis on preneoplastic changes induced by cadmium chloride in the rat ventral prostate.

    Directory of Open Access Journals (Sweden)

    Riánsares Arriazu

    Full Text Available BACKGROUND: Lysophosphatidic acid (LPA is a phospholipid growth factor involved in cell proliferation, differentiation, migration, inflammation, angiogenesis, wound healing, cancer invasion, and survival. This study was directed to evaluate the immunoexpression of LPA-1, cell proliferation, apoptosis, and angiogenesis markers in preneoplastic lesions induced with cadmium chloride in rat prostate. METHODS: The following parameters were calculated in ventral prostate of normal rats and rats that received Cd in drinking water during 24 months: percentages of cells immunoreactive to LPA-1 (LILPA1, PCNA (LIPCNA, MCM7 (LIMCM7, ubiquitin (LIUBI, apoptotic cells (LIAPO, and p53 (LIp53; volume fraction of Bcl-2 (VFBcl-2; and length of microvessels per unit of volume (LVMV/mm3. Data were analyzed using Student's t-test and Pearson correlation test. RESULTS: The LILPA1 in dysplastic lesions and normal epithelium of Cd-treated rats was significantly higher than those in the control group. Markers of proliferation were significantly increased in dysplastic lesions, whereas some apoptotic markers were significantly decreased. No significant differences between groups were found in VFBcl-2. Dysplastic lesions showed a significant increase of LIp53. The length of microvessels per unit of volume was elevated in dysplastic acini. Statistically significant correlations were found only between LILPA1 and LIUBI. CONCLUSIONS: Our results suggest that LPA-1 might be implicated in dysplastic lesions induced by cadmium chloride development. More studies are needed to confirm its potential contribution to the disease.

  14. Relational Issues Within Couples Coping With Parkinson's Disease: Implications and Ideas for Family-Focused Care.

    Science.gov (United States)

    Martin, Summer C

    2016-05-01

    The ways in which Parkinson's disease (PD) impacts, and is experienced by, the couple (i.e., the individual with PD and his or her spouse or other romantic partner) have not been fully elucidated. Such research is strongly warranted because when one member of a couple is chronically ill, it can cause major distress for not only the patient but also for his or her partner and their relationship. Therefore, the goal of this study was to examine how PD affects a couple's relationship. Data from 44 individual, in-depth interviews (with 21 persons with PD and 23 partners) revealed several challenges that PD commonly invokes in the patient-partner relationship, though most participants reported that PD had not decreased their overall relational closeness. The findings have significant practical implications for family-focused care. © The Author(s) 2016.

  15. Evaluation of Generic Issue 57: Effects of fire protection system actuation on safety-related equipment

    International Nuclear Information System (INIS)

    Lambright, J.; Bohn, M.; Lynch, J.; Ross, S.; Brosseau, D.

    1992-12-01

    Nuclear power plants have experienced actuations of fire protection systems (FPSs) under conditions for which these systems were not intended to actuate and also have experienced advertent actuations with the presence of a fire. These actuations have often damaged safety-related equipment. A review of the impact of past occurrences of both types of such events and their impact on plant safety systems, an analysis of the risk impacts of such events on nuclear power plant safety, and a cost-benefit analysis of potential corrective measures have been performed. Thirteen different scenarios leading to actuation of fire protection systems due to a variety of causes were identified. These scenarios ranged from inadvertent actuation caused by human error to hardware failure, and include seismic root causes and seismic/fire interactions. A quantification of these thirteen root causes, where applicable, was performed on generically applicable scenarios. This document, Volume 4, contains appendices E and F of this report

  16. Some stress-related issues in tokamak fusion reactor first walls

    International Nuclear Information System (INIS)

    Majumdar, S.; Pai, B.; Ryder, R.H.

    1987-01-01

    Recent design studies of a tokamak fusion power reactor and of various blankets have envisioned surface heat fluxes on the first wall ranging from 0.1 to 1.0 MW/m 2 , and end-of-life irradiation fluences ranging from 100 dpa for the austenitic stainless steels to as high as 250 dpa for postulated vanadium alloys. Some tokamak blankets, particularly those using helium or liquid metal as coolant/breeder, may have to operate at relatively high coolant pressures so that the first wall may be subjected to high primary stress in addition to high secondary stresses such as thermal stresses or stresses due to constrained swelling. The present paper focusses on the various problems that may arise in the first wall because of stress and high neutron fluence, and discusses some of the design solutions that have been proposed to overcome these problems

  17. The relevance of the psychometrist category as a professional resource: Training-related issues

    Directory of Open Access Journals (Sweden)

    René van Eeden

    2016-05-01

    Research purpose: The aim was to explore if the training of student psychometrists contributes to the relevance of this category in terms of the demographic profile of student psychometrists, the scope of services potentially provided by them and the content of training programmes. Motivation for the study: There is a paucity of research on training in the psychometrist category. Research design, approach and method: Data were obtained from the files of a cohort of student psychometrists who were registered in the Department of Psychology at the University of South Africa (UNISA. Follow-up surveys on training and work contexts were conducted amongst these students and their in-practice supervisors to confirm and supplement the data. In addition, a survey on the national availability of training programmes for psychometrists was conducted at South African universities. Main findings: Gender and racial skewness in terms of the demographic profile of the UNISA students seemed to reflect a national trend. In terms of the scope of services, training opportunities and perceived job opportunities for psychometrists seemed limited and despite the utilisation of the skills area in all the applied contexts, concerns related to the sectors being served were identified. With regard to the content of the training programmes, students and in-practice supervisors expressed a need for greater preparation in test use before related practical experience takes place. The importance of the university’s involvement during the practicum was also emphasised. Practical/managerial implications: Recommendations are made regarding the structure and content of training programmes. This information could be applied in adapting existing programmes and in developing new programmes. Contribution/value-add: Ultimately, these recommendations could contribute to the value of the psychometrist category as a professional resource relevant to a variety of settings.

  18. Future non-proliferation challenges

    International Nuclear Information System (INIS)

    Yelchenko, Volodymyr

    2008-01-01

    activities and illicit trafficking of nuclear material, equipment and technology. The strengthening of the physical protection of nuclear materials and facilities as an element of non-proliferation regime was highlighted. The proliferation risks associated with the growing global energy demand were also mentioned. In this regard, attention was drawn to the significance of developing proliferation resistant nuclear technologies, including through the international project on Innovative Nuclear Reactors and Fuel Cycles (INPRO). It is important to mention the discussion concerning the promotion of multilateralism in the nuclear fuel cycle and the supply of nuclear fuel, which was considered as a significant contribution to confidence-building in the field of non proliferation, to peaceful uses of nuclear energy and to the overall strength of the non-proliferation regime. The ongoing discussions in IAEA on fuel supply assurances mechanism were welcomed. The NPT relative success in slowing proliferation has been attributed to the combination of the political commitment by most states to the objective of non-proliferation, and a technical mechanism - IAEA safeguards - for verifying that this commitment is being honoured. Indeed, the IAEA will remain an indispensable part of the multilateral nuclear non proliferation regime and global security system and its role should be significantly strengthened. He hopes that the meeting will help to identify the ways of enhancing the important work of IAEA

  19. NRC program for the resolution of generic issues related to nuclear power plants. (Includes plans for the resolution of ''unresolved safety issues'' pursuant to Section 210 of the Energy Reorganization Act of 1974, as amended)

    International Nuclear Information System (INIS)

    1977-12-01

    This report provides a description of the Nuclear Regulatory Commission's Program for the Resolution of Generic Issues Related to Nuclear Power Plants. The NRC program is of considerably broader scope than the ''Unresolved Safety Issues Plan'' required by Section 210. The NRC program does include plans for the resolution of ''Unresolved Safety Issues''; however, in addition, it includes generic tasks for the resolution of environmental issues, for the development of improvements in the reactor licensing process and for consideration of less conservative design criteria or operating limitations in areas where over conservatisms may be unnecessarily restrictive or costly

  20. Using proliferation risk as a design metric in the development of nuclear systems

    International Nuclear Information System (INIS)

    Beard, C.; Lebouf, R.

    2001-01-01

    The necessity has arisen for newly proposed nuclear systems to be evaluated with regard to their potential aid to any proliferation. Thus, a mechanism is needed to introduce nonproliferation as a measure in the design phase of a new nuclear system. To accomplish this, a methodology for quantifying and measuring the proliferation risk of proposed system options is required. Such quantification has its difficulties due to inherent uncertainty, e.g. what is the probability that a quantity of material will be stolen in a given situation? Also, the lack of data on such occurrences makes the task of quantification nearly insurmountable. A systematic approach is necessary to estimate the proliferation risk. Currently, an advanced nuclear power system, the Accelerator Transmutation of Waste (ATW) program has been initiated to develop a system that will concurrently generate electricity while destroying long-lived radioactive isotopes. Therefore, because of the issues noted above, an effort to introduce proliferation risk into the design phase has been started. The purpose of this paper is to review previous work in quantification of proliferation risk in an effort to develop the proper basis for the current work. It should be noted that while proliferation on a national level has been studied extensively, efforts to quantify proliferation risk of individual nuclear systems or processes have been limited. Consequently, the available literature base is relatively sparse. (author)