WorldWideScience

Sample records for project delivery approaches

  1. Towards a project-based service delivery approach : Uncovering organisational tensions

    OpenAIRE

    12330841 - Van der Waldt, Gerrit

    2009-01-01

    In line with the modernizing, re-inventing and alternative service delivery paradigm, governments increasingly utilise project-based methodologies to improve service delivery. There is general agreement that projects are becoming increasingly important for government institutions to operationalise strategic objectives and policy programmes. This approach is commonly known as ‗Management-by-Projects‘. To adopt this approach requires of public institutions to adjust their existing structures...

  2. Generic project definitions for improvement of health care delivery: a case-based approach.

    Science.gov (United States)

    Niemeijer, Gerard C; Does, Ronald J M M; de Mast, Jeroen; Trip, Albert; van den Heuvel, Jaap

    2011-01-01

    The purpose of this article is to create actionable knowledge, making the definition of process improvement projects in health care delivery more effective. This study is a retrospective analysis of process improvement projects in hospitals, facilitating a case-based reasoning approach to project definition. Data sources were project documentation and hospital-performance statistics of 271 Lean Six Sigma health care projects from 2002 to 2009 of general, teaching, and academic hospitals in the Netherlands and Belgium. Objectives and operational definitions of improvement projects in the sample, analyzed and structured in a uniform format and terminology. Extraction of reusable elements of earlier project definitions, presented in the form of 9 templates called generic project definitions. These templates function as exemplars for future process improvement projects, making the selection, definition, and operationalization of similar projects more efficient. Each template includes an explicated rationale, an operationalization in the form of metrics, and a prototypical example. Thus, a process of incremental and sustained learning based on case-based reasoning is facilitated. The quality of project definitions is a crucial success factor in pursuits to improve health care delivery. We offer 9 tried and tested improvement themes related to patient safety, patient satisfaction, and business-economic performance of hospitals.

  3. Project delivery system (PDS)

    CERN Document Server

    2001-01-01

    As business environments become increasingly competitive, companies seek more comprehensive solutions to the delivery of their projects. "Project Delivery System: Fourth Edition" describes the process-driven project delivery systems which incorporates the best practices from Total Quality and is aligned with the Project Management Institute and ISO Quality Standards is the means by which projects are consistently and efficiently planned, executed and completed to the satisfaction of clients and customers.

  4. Generic project definitions for improvement of health care delivery: A case-base approach

    NARCIS (Netherlands)

    Niemeijer, G.C.; Does, R.J.M.M.; de Mast, J.; Trip, A.; van den Heuvel, J.

    2011-01-01

    Background: The purpose of this article is to create actionable knowledge, making the definition of process improvement projects in health care delivery more effective. Methods: This study is a retrospective analysis of process improvement projects in hospitals, facilitating a case-based reasoning

  5. Project management: a new service delivery paradigm

    Directory of Open Access Journals (Sweden)

    G. van der Walt

    2007-07-01

    Full Text Available In line with international trends in governance, the South African Government’s initial focus on the development of policy frameworks, structures and systems in order to give effect to the values and principles of the Constitution, shifted to the most critical issue, namely service delivery. The Government became increasingly aware that a significant expansion in the scope and quality of service provision was not possible with traditional delivery settings and approaches. There is growing evidence that there is a need for a significant departure from conventional approaches and that a leap into a new service delivery paradigm is necessary. Increasingly this new paradigm highlights the need to further develop the government’s project management skills and applications with a view to achieving improved delivery capability. In this article the focus will be placed on the changing service delivery paradigm – from an “old” traditional model through the transition to a “new” paradigm. This paradigm is shaped by international and national trends and events in government. The contribution and advantages of project management applications for effective governance are highlighted and the article concludes with an explanation of project management organisational arrangements necessary to support the new paradigm.

  6. Streamlining project delivery through risk analysis.

    Science.gov (United States)

    2015-08-01

    Project delivery is a significant area of concern and is subject to several risks throughout Plan Development : Process (PDP). These risks are attributed to major areas of project development, such as environmental : analysis, right-of-way (ROW) acqu...

  7. Integrated Project Delivery (IPD Research Trends.

    Directory of Open Access Journals (Sweden)

    Kahvandi, Z.

    2017-07-01

    Full Text Available Integrated Project Delivery (IPD is introduced as a vibrant approach to enhance project implementation, having particular position in recent studies among construction researchers. This study analyzes the research trends on the field of IPD to provide an appropriate vision for future researchers in this specialized field. While so far no comprehensive research has been done in this field, this study provides a comprehensive review of existing studies through in-depth literature review method. This research evaluates studies conducted in the field of IPD, which is a basis for future researchers to improve conditions of IPD implementation in different countries. For that this study Using library studies, the trend of researches conducted on various concepts and domains during various years, has been investigated. Future studies can simply use the outputs of this research to shape their research flow on establishing continuing progress of IPD. The data obtained from descriptive analyses are illustrated quantitatively, followed by comprehensive analyses and discussion of the results. Moreover, this study concluded that during recent years, the trend of studies conducted about IPD has increased, particularly articles examined challenges. In the next step, more studies have been performed in the field of construction. Those articles are preferred that have evaluated principles, challenges, and solutions for resolving barriers. Proper IPD implementation facilitates enhanced share of information and early identification of stakeholders through a proper timing as vital keys to realize objectives of the construction projects, reduce risks, and increase the chance of project success.

  8. Delivery improvements for CANDU projects

    International Nuclear Information System (INIS)

    Stephen Yu; Ken Hedges

    1998-01-01

    Future CANDU design will continue to meet emerging design and performance requirements as expected by the operating utilities, and will integrate new technologies into both the product features and work processes. Elements of this risk reduction strategy include feedback of lessons learned from operating plants, project experiences from previous projects, and replication of successful systems and equipment. Project implementation risk is minimized by up-front engineering and licensing prior to contract start. Enhanced competitiveness of the CANDU products is ensured by incorporating improvements based on updated technology. This paper summarizes the strategy used to enhance competitiveness of the CANDU products and the measures introduced to minimize risk during project implementation. This strategy provides a balance between innovation and proven designs; and between the desire for safety and operational improvements and the cost to achieve the improvements

  9. How can innovative project delivery systems improve the overall efficiency of GDOT in transportation project delivery?

    Science.gov (United States)

    2013-04-01

    The USDOT and Federal Highway Administration (FHWA) recommend the smart use of innovative project : delivery systems, such as design-build, to improve efficiency and effectiveness of developing transportation : projects. Although design-build provide...

  10. Analysis of the project parameters of the fixed price projects in the IT services delivery organization

    Directory of Open Access Journals (Sweden)

    Miroslav Kral

    2012-04-01

    Full Text Available The success rate of IS/IT projects is low. Thus, in response, a large variety of methods and approaches to managing IS/IT projects has been developed over the years. The purpose of this paper is to analyse the relationships between the project parameters of fixed-price projects that take place within an IT service delivery organization. There is some evidence that simply using traditional project parameters (such as project duration, costs, reserves, and so on isn't enough to increase the success of projects; rather, new approaches and methods, including our applied systems approach, should also be considered. This paper aims to highlight issues from the perspective of an IT services delivery organization from the CEE region. The output of the paper should be a contribution to the project management of IS/IT projects and to systems research, as well.

  11. Integrated project delivery : The designer as integrator

    NARCIS (Netherlands)

    Wamelink, J.W.F.; Koolwijk, J.S.J.; van Doorn, A.J.

    2012-01-01

    Process innovation related to integrated project delivery is an important topic in the building industry. Studies on process innovation through the use of integrated contracts usually focus on contractors, and particularly on the possibility of forward integration into the building process. Three

  12. A Systems Approach to Nitrogen Delivery

    Energy Technology Data Exchange (ETDEWEB)

    Goins, Bobby [Y-12 National Security Complex, Oak Ridge, TN (United States)

    2017-10-23

    A systems based approach will be used to evaluate the nitrogen delivery process. This approach involves principles found in Lean, Reliability, Systems Thinking, and Requirements. This unique combination of principles and thought process yields a very in depth look into the system to which it is applied. By applying a systems based approach to the nitrogen delivery process there should be improvements in cycle time, efficiency, and a reduction in the required number of personnel needed to sustain the delivery process. This will in turn reduce the amount of demurrage charges that the site incurs. In addition there should be less frustration associated with the delivery process.

  13. A Systems Approach to Nitrogen Delivery

    Energy Technology Data Exchange (ETDEWEB)

    Goins, Bobby [Y-12 National Security Complex, Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)

    2017-10-17

    A systems based approach will be used to evaluate the nitrogen delivery process. This approach involves principles found in Lean, Reliability, Systems Thinking, and Requirements. This unique combination of principles and thought process yields a very in depth look into the system to which it is applied. By applying a systems based approach to the nitrogen delivery process there should be improvements in cycle time, efficiency, and a reduction in the required number of personnel needed to sustain the delivery process. This will in turn reduce the amount of demurrage charges that the site incurs. In addition there should be less frustration associated with the delivery process.

  14. Managing projects a team-based approach

    CERN Document Server

    Brown, Karen A

    2010-01-01

    Students today are likely to be assigned to project teams or to be project managers almost immediately in their first job. Managing Projects: A Team-Based Approach was written for a wide range of stakeholders, including project managers, project team members, support personnel, functional mangers who provide resources for projects, project customers (and customer representatives), project sponsors, project subcontractors, and anyone who plays a role in the project delivery process. The need for project management is on the rise as product life cycles compress, demand for IT systems increases, and business takes on an increasingly global character. This book adds to the project management knowledge base in a way that fills an unmet need—it shows how teams can apply many of the standard project management tools, as well as several tools that are relatively new to the field. Managing Projects: A Team-Based Approach offers the academic rigor found in most textbooks along with the practical attributes often foun...

  15. Efficient Project Delivery Using Lean Principles - An Indian Case Study

    Science.gov (United States)

    Kovvuri, P. Ramachandra Reddy; Sawhney, Anil; Ahuja, Ritu; Sreekumar, Aiswarya

    2016-03-01

    Construction industry in India is growing at a rapid pace. Along with this growth, the industry is facing numerous challenges that are making delivery of projects inefficient. Experts believe that capacity constraints in the industry need to be addressed immediately. Government has recommended `introduction of efficient technologies and modern management techniques' to increase the productivity of the industry. In this context, lean principles can act as a lever to make project delivery more efficient and provide the much needed impetus to the Indian construction sector. Around the globe lean principles are showing positive results on the projects. Project teams are reporting improvements in construction time, cost and quality along with softer benefits of enhanced collaboration, coordination and trust in project teams. Can adoption of lean principles provide similar benefits in the Indian construction sector? This research was conducted to answer this question. Using an action research approach a key lean construction tool called Last Planner System (LPS) was tested on a large Indian construction project. The work described in this work investigates the improvements achieved in project delivery by adopting LPS in Indian construction sector. Comparison in pre- and post-implementation data demonstrates increase in the certainty of work-flow and improves schedule compliance. This is measured through a simple LPS metric called percent plan complete. Explicit improvements in schedule performance are seen during 8 week LPS implementation along with implicit improvements in coordination, collaboration and trust in the project team. This work reports the findings of LPS implementation on the case study project outlining the barriers and drivers to adoption, strategies needed to ensure successful implementation and roadmap for implementation. Based on the findings the authors envision that lean construction can make project delivery more efficient in India.

  16. Effective and efficient implementation of alternative project delivery : research summary.

    Science.gov (United States)

    2017-05-01

    Alternative project delivery (APD) methods such as Design Build (DB) and Construction Manager at Risk (CMAR), are used by state departments of transportation to improve the efficiency and effectiveness of project delivery. The Maryland Department of ...

  17. 33 CFR 385.17 - Project Delivery Team.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Project Delivery Team. 385.17... Processes § 385.17 Project Delivery Team. (a) In accordance with the procedures of the Corps of Engineers...,” the Corps of Engineers and the non-Federal sponsor shall form a Project Delivery Team to develop the...

  18. Evaluation on Collaborative Satisfaction for Project Management Team in Integrated Project Delivery Mode

    Science.gov (United States)

    Zhang, L.; Li, Y.; Wu, Q.

    2013-05-01

    Integrated Project Delivery (IPD) is a newly-developed project delivery approach for construction projects, and the level of collaboration of project management team is crucial to the success of its implementation. Existing research has shown that collaborative satisfaction is one of the key indicators of team collaboration. By reviewing the literature on team collaborative satisfaction and taking into consideration the characteristics of IPD projects, this paper summarizes the factors that influence collaborative satisfaction of IPD project management team. Based on these factors, this research develops a fuzzy linguistic method to effectively evaluate the level of team collaborative satisfaction, in which the authors adopted the 2-tuple linguistic variables and 2-tuple linguistic hybrid average operators to enhance the objectivity and accuracy of the evaluation. The paper demonstrates the practicality and effectiveness of the method through carrying out a case study with the method.

  19. Governance Impact Assessment on Large Infrastructure Project (LIP Delivery

    Directory of Open Access Journals (Sweden)

    G. A. Zarewa

    2018-01-01

    Full Text Available The linkage of failures of many projects, including Large Infrastructure Projects (LIPs, to governance problems by previous studies implies that governance impacts projects’ performance. Identification and understanding of the impacts have therefore become necessary in order to ensure that projects are governed in a way that will ensure their successful delivery. This study assessed impact of governance on delivery of Large Infrastructure Projects (LIPs through a three phase research approach. The first phase involved literature review followed by semi-structured interviews with key stakeholders/role players in the governance of eight LIPs in different locations in Nigeria in the second phase. A thematic data analysis of the study’s findings was finally conducted in the third phase to identify themes and sub-themes after which conclusions were drawn. The study established that governance impacts LIPs delivery both positively and negatively depending on how the governance is approached. Four LIPs were successful due to proper initiation, setting aside funds for the projects at the onset, proactive risk management, top management support, and simple governance policies and structures. Intuitive initiation on political exigencies, tying funding to erratic sources of funding without contingency arrangement, Procuring Authorities’ (PAs disregard for due process and consultants’ advice, failure of a Procuring Authority (PA to meet contractual obligations and change of government were identified by the study as major governance aspects that led to the abandonment of 4 LIPs. The study concluded that there was a need for significant improvement and standardisation of approaches to governance of LIPs particularly in developing countries like Nigeria and accordingly recommends the development of a governance framework containing guidelines, including sanctions for violators, to guide the governance of the projects in the country.

  20. Project configured supply networks: Governance of delivery and failures in operations

    DEFF Research Database (Denmark)

    Koch, Christian

    2008-01-01

    of delivery types; parts, components and subsystems. The project configuration and orchestrated governance forms are not always successful, and failures emerge. The paper aims at studying governance forms in delivery networks using operational failures as litmus. Operation management approaches is used...... failures occurred during three month observation. The costs were 8 pct. of the production budget. None of the mobilised governance forms fully prevented failures, especially subsystem delivery and internal integration was underperforming.......  Supply networks in complex B2B- construction deliver knowledge, materials, components, subsystems, competences, workforce and management. The delivery network and its governance forms are partly permanent, partly project specific. Integration upstream varies by project, constituting a range...

  1. Efficient and effective implementation of alternative project delivery methods.

    Science.gov (United States)

    2017-05-01

    Over the past decade, the Maryland Department of Transportation State Highway : Administration (MDOT SHA) has implemented Alternative Project Delivery (APD) methods : in a number of transportation projects. While these innovative practices have produ...

  2. Advanced drug delivery approaches against periodontitis.

    Science.gov (United States)

    Joshi, Deeksha; Garg, Tarun; Goyal, Amit K; Rath, Goutam

    2016-01-01

    Periodontitis is an inflammatory disease of gums involving the degeneration of periodontal ligaments, creation of periodontal pocket and resorption of alveolar bone, resulting in the disruption of the support structure of teeth. According to WHO, 10-15% of the global population suffers from severe periodontitis. The disease results from the growth of a diverse microflora (especially anaerobes) in the pockets and release of toxins, enzymes and stimulation of body's immune response. Various local or systemic approaches were used for an effective treatment of periodontitis. Currently, controlled local drug delivery approach is more favorable as compared to systemic approach because it mainly focuses on improving the therapeutic outcomes by achieving factors like site-specific delivery, low dose requirement, bypass of first-pass metabolism, reduction in gastrointestinal side effects and decrease in dosing frequency. Overall it provides a safe and effective mode of treatment, which enhances patient compliance. Complete eradication of the organisms from the sites was not achieved by using various surgical and mechanical treatments. So a number of polymer-based delivery systems like fibers, films, chips, strips, microparticles, nanoparticles and nanofibers made from a variety of natural and synthetic materials have been successfully tested to deliver a variety of drugs. These systems are biocompatible and biodegradable, completely fill the pockets, and have strong retention on the target site due to excellent mucoadhesion properties. The review summarizes various available and recently developing targeted delivery devices for the treatment of periodontitis.

  3. Managing projects using a project management approach

    Directory of Open Access Journals (Sweden)

    Marko D. Andrejić

    2011-04-01

    Full Text Available Modern management theory treats all complex tasks and duties like projects and make these projects possible to be managed by a particular organizational-management concept in order to achieve a goal effectively. A large number of jobs and tasks performed in the system of defense or for defense purposes have the characteristics of projects. Project management is both a skill and a science of monitoring human, material, financial, energy and other resources to achieve required objectives within the given limits: deadlines, time, budget, possibility of realization and the satisfaction of the interests of all project participants. Project management is a traditional area of applied (or functional management focused on managing complex and uncertain situations with defined goals. Introduction In conditions of rapid change and high uncertainty, only adaptive organizations survive, i. e. those that are able not only to react quickly to changes but also to proactively take advantage of changes. Development of project management The biggest influence on the development of the area had complex jobs within the engineering profession. In parallel with the traditional approach new approaches began to develop, while the traditional one still remained in use. Contrary to the traditional engineering approach, a dynamic model first developed in order to respond to demands for greater control of costs. Project management Project management is a skill and knowledge of human and material resources to achieve set objectives within prescribed limits: deadlines, time, budget, possibility of realization, and the satisfaction of all participants in the project. In order to realize a project effectively, it is necessary to manage it rationally. Planning and project management A project plan is a document that allows all team members insight on where to go, when to start and when to arrive, what is necessary to be done in order to achieve the project objectives and what

  4. Drug delivery approaches for breast cancer

    Directory of Open Access Journals (Sweden)

    Singh SK

    2017-08-01

    Full Text Available Santosh Kumar Singh,1 Shriti Singh,2 James W Lillard Jr,1 Rajesh Singh1 1Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA; 2Department of Kriya Sharir, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India Abstract: Breast cancer is one of the most common cancers affecting women worldwide. The controlled release of drugs to the precise site of the disease using a nanocarrier vehicle increases the therapeutic efficiency of the drugs. Nanotechnology-based approaches used to endorse clinical improvement from a disease also help to understand the interaction of malignant cells with their microenvironment. Receptor-based targeting is another approach for drug delivery which is undergoing clinical trials. Nanoparticles (NPs delivery has been proven to promise high loading capacity, less toxicity, and stability of the drugs or biomolecules compared to traditional chemotherapeutic drugs. The goal of this review is to present the current problems of breast cancer therapy and discuss the NP-based targeting to overcome the hurdles of conventional drug therapy approach. Keywords: breast cancer, nanoparticles, drug delivery systems

  5. Integrated project delivery methods for energy renovation of social housing

    Directory of Open Access Journals (Sweden)

    Tadeo Baldiri Salcedo Rahola

    2015-11-01

    difference between the three methods is the time frame for the involvement of the different actors and the contractual relationship with the SHO. In DBB, the various contracted parties are involved in the project one after the other, while in DB design companies and construction companies are involved during the same time period, and in DBM all three parties are involved during the same time period. Under DB, the SHO tenders the design and construction work in a single contract and under DBM it tenders the design, construction and maintenance work in a single contract. The contracted entity may be a single company, with or without subcontractors, or a consortium. SBS and DBB are the most commonly used project delivery methods for social housing renovation projects, although DB and DBM are also used for a small number of projects. The vast majority of SHOs use more than one project delivery method simultaneously, mainly a combination of SBS and DBB. For new-build projects, DBB has traditionally been considered the most commonly used project delivery method; however, our survey revealed that it is in fact the second most commonly used project delivery method after SBS. The DBM approach has the maximum potential for delivering energy savings, because it facilitates collaboration between the different actors and promotes their commitment to achieving project goals. Furthermore, DBM offers greater price certainty and less risk of design failure compared to other project delivery methods. However, the project delivery method cannot guarantee the achievement of targeted energy savings by itself. Numerous factors need to be taken into account when considering a change in the project delivery method. The property asset management of the dwelling stock that is renovated using SBS, which focuses on building elements and systems, is completely different from the property asset management of the dwelling stock renovated by DBB, DB or DBM, which focuses on entire properties. It is

  6. Four Approaches to Project Evaluation

    DEFF Research Database (Denmark)

    Laursen, Markus; Svejvig, Per; Rode, Anna Le Gerstrøm

    . Each of the framework’s four approaches provides a distinct evaluation that sheds light on some issues while leaving others unattended. Following these lines, the paper calls for more multi-faceted project evaluations. Introducing a framework that can help analyze existing evaluations and structure......There are many theoretical and practical reasons for evaluating projects – including explorative arguments focusing on expanding descriptive knowledge on project work as well as normative arguments focusing on improving prescriptive models of project performance. Despite the need for project...... management methodologies that work and combat project failure, and research methods that can assess effective project management and methodologies, as well as empirical research on the actuality of projects as practice, evaluation research on projects including project management and methodologies is scarce...

  7. Reactors Project Delivery: The Value of Experiance

    International Nuclear Information System (INIS)

    Stosic, V. Zoran

    2014-01-01

    State of Affairs: Energy Potential and Density versus Environmental Load of different Energy Sources, Development of Fuel into Energy/Electricity Generation, Production Costs of Electricity, Contributions of Nuclear Energy to Security of Energy Supply, Recent Nuclear Development, Public Support growing again. Projects Status: Reactors under Construction, Different Projects Industrial Schemes, Projects Overview. The Value of Experience: Licensing, Standardization on Early Engineering Activities, Supply Chain and Manufacturing of Heavy Components, Installation, Procurement. (author)

  8. EPR trademark project delivery. The value of experience

    International Nuclear Information System (INIS)

    Leverenz, Ruediger

    2013-01-01

    We are building the EPR trademark reactor fleet. Together. With four EPR trademark projects under construction in the world, AREVA has unrivalled experience in the delivery of large-scale nuclear projects, including more than a thousand lessons learned captured from Olkiluoto 3 and Flamanville 3 projects. This book of knowledge as well as the return of experience of AREVA's and EDF's teams are now being fully leveraged on ongoing projects, especially on Flamanville 3 and Taishan, and will be incorporated in all future EPR TM projects.

  9. Benchmarking Sustainability Practices Use throughout Industrial Construction Project Delivery

    Directory of Open Access Journals (Sweden)

    Sungmin Yun

    2017-06-01

    Full Text Available Despite the efforts for sustainability studies in building and infrastructure construction, the sustainability issues in industrial construction remain understudied. Further, few studies evaluate sustainability and benchmark sustainability issues in industrial construction from a management perspective. This study presents a phase-based benchmarking framework for evaluating sustainability practices use focusing on industrial facilities project. Based on the framework, this study quantifies and assesses sustainability practices use, and further sorts the results by project phase and major project characteristics, including project type, project nature, and project delivery method. The results show that sustainability practices were implemented higher in the construction and startup phases relative to other phases, with a very broad range. An assessment by project type and project nature showed significant differences in sustainability practices use, but no significant difference in practices use by project delivery method. This study contributes to providing a benchmarking method for sustainability practices in industrial facilities projects at the project phase level. This study also discusses and provides an application of phase-based benchmarking for sustainability in industrial construction.

  10. Transdermal drug delivery: approaches and significance

    OpenAIRE

    Murthy, SATHYANARAYANA

    2012-01-01

    S Narasimha MurthyDepartment of Pharmaceutics, The University of Mississippi, USATransdermal drug delivery systems deliver drugs through the skin as an alternative to oral, intravascular, subcutaneous, and transmucosal routes. Potential advantages of transdermal delivery include, but are not limited to, elimination of first-pass metabolism, steady delivery/blood levels, better patient compliance, reduced systemic drug interactions, possible dose intervention, avoidance of medically assisted d...

  11. Innovation in Healthcare Delivery: Commentary on an Evolutionary Approach.

    Science.gov (United States)

    Fields, Anthony L A

    2015-01-01

    Zwarenstein (2015) proposes a novel approach to healthcare innovation that parallels biological evolution, based on stimulation and reward of multiple small competing innovation projects conducted in the field by decentralized teams. Projects would be designed with explicit outcome targets and results would be widely disseminated and publicly available. More successful projects would be grown and spread. Critical to the model is accepting and reporting failure as well as success, for the benefit of future project design. Examining biological evolution for lessons for healthcare delivery innovation illuminates the need for diversity among healthcare systems to achieve optimum application of best practice interventions across jurisdictions with differing population, provider and facility characteristics. However, careful coordination will be needed to achieve the balance between diversity and harmony across jurisdictions necessary for effective governance and interaction. There are important methodological issues to be addressed to reduce the uncertainty inherent in comparisons of results among discrete innovation projects, especially when observed improvements over the baseline are modest. As well as evolutionary improvement in healthcare outcomes, the model should progressively increase decentralized capacity and expertise in innovation processes.

  12. PROJECT APPROACH TO ENERGY MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Інга Борисівна СЕМКО

    2016-02-01

    Full Text Available Project management is widely used around the world as a tool to improve business performance. Correct implementation of the program of implementation of energy efficiency is accompanied by the adoption of an appropriate legislative framework, support programs, the approval of market-based instruments. Currently, it is paying enough attention to the effective application of market-based instruments, although most of the activities in the field of energy efficiency from the economic side are quite profitable. The authors suggested the use of the methodology of project management to the management of energy-saving measures, new approaches to the place and role of project management in the hierarchy of guidance. As a result, this innovation can improve the competitiveness of enterprises. The conclusions that the energy-saving project management allows you to get the best results for their implementation by reducing the time, resources, risk reduction.

  13. Project Delivery Acquisition and Contracting Plan for the Tank Farm Contractor

    International Nuclear Information System (INIS)

    MERCADO, L.C.

    2000-01-01

    This document is a plan presenting the process, strategies and approaches for vendor contracting by the Tank Farm Contractor. The plan focuses on contracting structures, practices, methods, and desired approaches in contracting. The U.S. Department of Energy (DOE), Office of River Protection (ORP) has contracted with the CH2M HILL Hanford Group, Inc. (CHG), as the Tank Farm Contractor (TFC), to support vitrification of Hanford Site tank waste by the Privatization Contractor. During Waste Feed Delivery Phase 1, waste will be retrieved from certain double-shell tanks and delivered to the Privatization Contractor to meet contract feed delivery requirements. Near-term project goals include upgrading infrastructure systems; retrieving and delivering the waste; and accepting the waste packages for interim onsite storage and disposal. Project Delivery includes individual projects assigned to provide the infrastructure and systems responsible to provide engineering, design, procurement, installation/construction, and testing/turnover of systems for retrieval of waste from Hanford double-shell tanks. This plan sets the requirements for projects work scope, contracting practices, structures, methods, and performance measurements. The plan is designed to integrate Life-Cycle Projects acquisitions and provide a consistent contracting approach. This effort will serve as a step improvement in contract reform implementing commercial practices into DOE projects

  14. Effect of bond administration on construction project delivery

    Directory of Open Access Journals (Sweden)

    Oke Ayodeji Emmanuel

    2016-12-01

    Full Text Available Construction bond administration involves management of bond issues from inception of obtaining bond from guarantor to the point of release of contractor by the client. This process has posted a lot of challenges to construction stakeholders; it is therefore, necessary to examine the relationship between bond administration and project success. Archival data of completed bonded building projects were gathered through a pro forma developed for this purpose. Using Pearson product moment of correlation, it was revealed that the cost of securing a construction bond has a positive and significant effect on the initial and final costs of the project, while the number of days needed to secure a construction bond has no significant effect on the initial and final durations of the construction project. In order to establish the relationship between project delivery indices of cost and time and the construction bond administration variables, iteration of linear regression was adopted to arrive at the best-fit equation. Factors affecting the cost of securing construction bonds from guarantors should be identified and given adequate attention by construction stakeholders in order to minimize the effect of construction bond administration on project delivery.

  15. Wood chip delivery and research project at Mikkeli region

    International Nuclear Information System (INIS)

    Saksa, T.; Auvinen, P.

    1995-01-01

    In 1994, a large-scale energywood production chain was started as a co-operation project by the Mikkeli city forest office and local forestry societies. Over 60 000 m 3 (about 46 000 MWh of energy) of forest processed chips were delivered to Pursiala heat and power plant in Mikkeli. About 60 % of these chips was whole tree chips from improvement cuttings of young forest stands and the rest was logging waste chips from regeneration cutting areas. The average total delivery costs of forest processed chips after reduction of energywood and other subsidies were approximately 51 FIM/m 3 (68 FIM/MWh) for the whole tree chips and 40 FIM/m 3 (53 FIM/MWh) for logging waste chips. The delivery costs of wood chips could compete with those of fuel peat only in the most favourable cases. The resources of forest processed chips were studied on the basis of forestry plans. According to the study, there is enough raw material for permanent, large-scale delivery of forest processed chips (up to 250 000 m 3 /a) in the forests located at a distance of under 40 road kilometers from the Pursiala heat and power plant. The following project stages will involve further development of the wood chip delivery chain logistics, as well as improvement of logging and chipping equipment and methods in energywood and logging waste production. Also the effects of wood energy production on the economy and environment of the whole Mikkeli region will be studied. (author)

  16. Hamburgian weapon delivery technology: a quantitative comparative approach

    DEFF Research Database (Denmark)

    Riede, Felix

    2010-01-01

    cran). Numerous studies have addressed the question of whether these points tipped arrows fired from bows, darts launched with the help of spear-throwers, or some other projectile delivery weapon. This paper approaches the question of Hamburgian weapon delivery technology from a quantitative...

  17. Towards effective extension delivery approach and strategies for ...

    African Journals Online (AJOL)

    Towards effective extension delivery approach and strategies for food security poverty ... Journal Home > Vol 6, No 1 (2010) > ... groups, promotion of best practices and environment friendly initiatives among others were recommended.

  18. Atopic Dermatitis: Drug Delivery Approaches in Disease Management.

    Science.gov (United States)

    Lalan, Manisha; Baweja, Jitendra; Misra, Ambikanandan

    2015-01-01

    In this review, we describe the very basic of atopic dermatitis (AD), the established management strategies, and the advances in drug delivery approaches for successful therapeutic outcomes. The multifactorial pathophysiology of AD has given rise to the clinician's paradigm of topical and systemic therapy and potential combinations. However, incomplete remission of skin disorders like AD is a major challenge to be overcome. Recurrence is thought to be due to genetic and immunological etiologies and shortcomings in drug delivery. This difficulty has sparked research in nanocarrier-based delivery approaches as well as molecular biology-inspired stratagems to deal with the immunological imbalance and to address insufficiencies of delivery propositions. In this review, we assess various novel drug delivery strategies in terms of their success and utility. We present a brief compilation and assessment of management modalities to sensitize the readers to therapeutic scenario in AD.

  19. Project Delivery System Mode Decision Based on Uncertain AHP and Fuzzy Sets

    Science.gov (United States)

    Kaishan, Liu; Huimin, Li

    2017-12-01

    The project delivery system mode determines the contract pricing type, project management mode and the risk allocation among all participants. Different project delivery system modes have different characteristics and applicable scope. For the owners, the selection of the delivery mode is the key point to decide whether the project can achieve the expected benefits, it relates to the success or failure of project construction. Under the precondition of comprehensively considering the influence factors of the delivery mode, the model of project delivery system mode decision was set up on the basis of uncertain AHP and fuzzy sets, which can well consider the uncertainty and fuzziness when conducting the index evaluation and weight confirmation, so as to rapidly and effectively identify the most suitable delivery mode according to project characteristics. The effectiveness of the model has been verified via the actual case analysis in order to provide reference for the construction project delivery system mode.

  20. Recent developments in protein and peptide parenteral delivery approaches

    Science.gov (United States)

    Patel, Ashaben; Cholkar, Kishore; Mitra, Ashim K

    2014-01-01

    Discovery of insulin in the early 1900s initiated the research and development to improve the means of therapeutic protein delivery in patients. In the past decade, great emphasis has been placed on bringing protein and peptide therapeutics to market. Despite tremendous efforts, parenteral delivery still remains the major mode of administration for protein and peptide therapeutics. Other routes such as oral, nasal, pulmonary and buccal are considered more opportunistic rather than routine application. Improving biological half-life, stability and therapeutic efficacy is central to protein and peptide delivery. Several approaches have been tried in the past to improve protein and peptide in vitro/in vivo stability and performance. Approaches may be broadly categorized as chemical modification and colloidal delivery systems. In this review we have discussed various chemical approaches such as PEGylation, hyperglycosylation, mannosylation, and colloidal carriers including microparticles, nanoparticles, liposomes, carbon nanotubes and micelles for improving protein and peptide delivery. Recent developments on in situ thermosensitive gel-based protein and peptide delivery have also been described. This review summarizes recent developments on some currently existing approaches to improve stability, bioavailability and bioactivity of peptide and protein therapeutics following parenteral administration. PMID:24592957

  1. Synthesis of the project leadership staffing needs for successful development of alternative delivery programs.

    Science.gov (United States)

    2017-08-01

    This research provides a synthesis of practices in organizational structuring and professional staffing of the innovative delivery units in several state DOTs across the nation that are actively utilizing alternative project delivery. Several major c...

  2. The hands-on project office guaranteeing ROI and on-time delivery

    CERN Document Server

    Kesner, Richard M

    2003-01-01

    THE THREE PILLARS OF IT DELIVERY - PROBLEM RESOLUTION, SERVICE REQUESTS, AND PROJECTSIntroduction The Business Context The Internal Economy for Investing in IT Services and ProjectsThe Three Pillars of IT Delivery Managing Service DeliveryManaging Project Commitments IT Metrics and Reporting Tools THE PROJECT MANAGEMENT OFFICE BUSINESS MODELIntroduction: Revisiting the IT Organization IT Service and Project Delivery RolesThe Role of the Project Management Office: Measuring its ROI The PMO Value Proposition: An Initial ROI Estimate ALIGNMENT AND PLANNING - DOING THE RIGHT THINGS Introduction Ge

  3. Systems approach to project risk management

    Energy Technology Data Exchange (ETDEWEB)

    Kindinger, J. P. (John P.)

    2002-01-01

    This paper describes the need for better performance in the planning and execution of projects and examines the capabilities of two different project risk analysis methods for improving project performance. A quantitative approach based on concepts and tools adopted from the disciplines of systems analysis, probabilistic risk analysis, and other fields is advocated for managing risk in large and complex research & development projects. This paper also provides an overview of how this system analysis approach for project risk management is being used at Los Alamos National Laboratory along with examples of quantitative risk analysis results and their application to improve project performance.

  4. Transportation risk management : international practices for program development and project delivery.

    Science.gov (United States)

    2012-08-01

    Managing transportation networks, including agency : management, program development, and project : delivery, is extremely complex and fraught with : uncertainty. Administrators, planners, and engineers : coordinate a multitude of organizational and ...

  5. Simple and reusable picoinjector for liquid delivery via nanofluidics approach

    KAUST Repository

    Li, Shunbo; Cao, Wenbin; Hui, Yu Sanna; Wen, Weijia

    2014-01-01

    Precise control of sample volume is one of the most important functions in lab-on-a-chip (LOC) systems, especially for chemical and biological reactions. The common approach used for liquid delivery involves the employment of capillaries and microstructures for generating a droplet which has a volume in the nanoliter or picoliter range. Here, we report a novel approach for constructing a picoinjector which is based on well-controlled electroosmotic (EO) flow to electrokinetically drive sample solutions. This picoinjector comprises an array of interconnected nanochannels for liquid delivery. Such technique for liquid delivery has the advantages of well-controlled sample volume and reusable nanofluidic chip, and it was reported for the first time. In the study of the pumping process for this picoinjector, the EO flow rate was determined by the intensity of the fluorescent probe. The influence of ion concentration in electrolyte solutions over the EO flow rate was also investigated and discussed. The application of this EO-driven picoinjector for chemical reactions was demonstrated by the reaction between Fluo-4 and calcium chloride with the reaction cycle controlled by the applied square waves of different duty cycles. The precision of our device can reach down to picoliter per second, which is much smaller than that of most existing technologies. This new approach, thus, opens further possibilities of adopting nanofluidics for well-controlled chemical reactions with particular applications in nanoparticle synthesis, bimolecular synthesis, drug delivery, and diagnostic testing.

  6. Simple and reusable picoinjector for liquid delivery via nanofluidics approach

    KAUST Repository

    Li, Shunbo

    2014-03-25

    Precise control of sample volume is one of the most important functions in lab-on-a-chip (LOC) systems, especially for chemical and biological reactions. The common approach used for liquid delivery involves the employment of capillaries and microstructures for generating a droplet which has a volume in the nanoliter or picoliter range. Here, we report a novel approach for constructing a picoinjector which is based on well-controlled electroosmotic (EO) flow to electrokinetically drive sample solutions. This picoinjector comprises an array of interconnected nanochannels for liquid delivery. Such technique for liquid delivery has the advantages of well-controlled sample volume and reusable nanofluidic chip, and it was reported for the first time. In the study of the pumping process for this picoinjector, the EO flow rate was determined by the intensity of the fluorescent probe. The influence of ion concentration in electrolyte solutions over the EO flow rate was also investigated and discussed. The application of this EO-driven picoinjector for chemical reactions was demonstrated by the reaction between Fluo-4 and calcium chloride with the reaction cycle controlled by the applied square waves of different duty cycles. The precision of our device can reach down to picoliter per second, which is much smaller than that of most existing technologies. This new approach, thus, opens further possibilities of adopting nanofluidics for well-controlled chemical reactions with particular applications in nanoparticle synthesis, bimolecular synthesis, drug delivery, and diagnostic testing.

  7. Identifying Issues in Applying Integrated Project Delivery to Domestic Nuclear Power Plant Construction Projects

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Joo [Korean Nuclear Society, Daejeon (Korea, Republic of)

    2016-05-15

    Integrated Project Delivery (IPD) is defined as that people, systems, business structures, and practices of key stakeholders are incorporated into a single-team, with a single process, which executes a project in a way of optimizing the project's outcome, increasing values delivered to the end user, reducing waste, and maximizing efficiency throughout the phases of engineering to construction. The researcher had carried out literature review in terms of IPD to identify major characteristics of IPD which are presented in the following section and had compared such characteristics against peculiarities of nuclear power plant (NPP) construction projects in order to shed light on obstacles in possible application of IPD method to domestic NPP construction projects in the coming days. In this research, three (3) major characteristics of IPD were identified: 1) key stakeholders signing one balanced contract, forming de facto one body, sharing risk and reward 2) an integrated project team being formed in the early stage of a project and providing input to minimize time and cost loss from rework downstream 3) team members co-locating, having open and direct communication, making decisions on time, and pursuing the success of the project itself.

  8. The interplay between formal and informal contracting in integrated project delivery

    NARCIS (Netherlands)

    Bygballe, L.E.; Dewulf, Geert P.M.R.; Levitt, R.

    2015-01-01

    This research examines the interplay between formal and informal contracting in integrated project delivery (IPD). It investigates how the interplay enables parties in health-care construction projects to cope with uncertainty and complexities, due to, among others, changing demands. New delivery

  9. Design Project on Controlled-Release Drug Delivery Devices: Implementation, Management, and Learning Experiences

    Science.gov (United States)

    Xu, Qingxing; Liang, Youyun; Tong, Yen Wah; Wang, Chi-Hwa

    2010-01-01

    A design project that focuses on the subject of controlled-release drug delivery devices is presented for use in an undergraduate course on mass transfer. The purpose of the project is to introduce students to the various technologies used in the fabrication of drug delivery systems and provide a practical design exercise for understanding the…

  10. Project approach helps technology transfer

    International Nuclear Information System (INIS)

    Walcher, M.W.

    1982-01-01

    The placing of the contract by the National Power Corporation with Westinghouse for the Philippines nuclear power plant (PNPP-1) is described. Maximised use of Philippine contractors under Westinghouse supervision was provided for. Technology transfer is an important benefit of the contract arrangements, since National Power Corporation project management acquires considerable nuclear plant experience during plant construction through consultation with technical personnel. (U.K.)

  11. The Japanese approach to financing LNG projects

    International Nuclear Information System (INIS)

    Aoki, Wataru

    1995-01-01

    The Japanese approach approach to financing LNG project has been what could be called a combined purchase and finance system which has been arranged mainly at the initiative of japan's Sogo Shosh (general trading companies) with the support of japanese governmental financial agencies and a purchase commitment from japanese utilities. In the QATARGAS project, despite it being the first greenfield LNG project in decade since North West Shelf Australia LNG project, financing for the LNG plant phase has been successfully arranged through Japanese financing. The structuring of the financial facilities for the QATARGAS project seems to have lessons for future development of the next generation of greenfield LNG projects. Discharge of the parties' liability, proper sharing of the risk burden and reconfirmation of the spirit of mutual understanding and trust among the parties concerned are key factors for the success of any new LNG project in the future. (Author)

  12. Nanotechnology based approaches for anti-diabetic drugs delivery.

    Science.gov (United States)

    Kesharwani, Prashant; Gorain, Bapi; Low, Siew Yeng; Tan, Siew Ann; Ling, Emily Chai Siaw; Lim, Yin Khai; Chin, Chuan Ming; Lee, Pei Yee; Lee, Chun Mey; Ooi, Chun Haw; Choudhury, Hira; Pandey, Manisha

    2018-02-01

    Nanotechnology science has been diverged its application in several fields with the advantages to operate with nanometric range of objects. Emerging field of nanotechnology has been also being approached and applied in medical biology for improved efficacy and safety. Increased success in therapeutic field has focused several approaches in the treatment of the common metabolic disorder, diabetes. The development of nanocarriers for improved delivery of different oral hypoglycemic agents compared to conventional therapies includes nanoparticles (NPs), liposomes, dendrimer, niosomes and micelles, which produces great control over the increased blood glucose level and thus becoming an eye catching and most promising technology now-a-days. Besides, embellishment of nanocarriers with several ligands makes it more targeted delivery with the protection of entrapped hypoglycaemic agents against degradation, thereby optimizing prolonged blood glucose lowering effect. Thus, nanocarriers of hypoglycemic agents provide the aim towards improved diabetes management with minimized risk of acute and chronic complications. In this review, we provide an overview on distinctive features of each nano-based drug delivery system for diabetic treatment and current NPs applications in diabetes management. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. A Multi-organisational Approach to Service Delivery

    Science.gov (United States)

    Purchase, Valerie; Mills, John; Parry, Glenn

    Who is involved in delivering a service? There has been growing recognition in a wide variety of contexts that service is increasingly being delivered by multi-rather than single-organisational entities. Such recognition is evident not only in our experience but in a number of areas of literature including strategy development, core competence analysis, operations and supply chain management, and is reflected in and further facilitated by ICT developments. Customers have always been involved in some degree in the process of value delivery and such involvement is increasing to include complex co-creation of value. Such interactions are challenging when they involve individual customers, however, this becomes ever more challenging when the 'customer' is another organisation or when there are multiple 'customers'. Within this chapter we will consider some of the key drivers for a multi-organisational approach to service delivery; examine the ways in which the parties involved in service co-creation have expanded to include multiple service providers and customers; and finally, identify some of the challenges created by a multi-organisational approach to service delivery.

  14. Nursing Services Delivery Theory: an open system approach

    Science.gov (United States)

    Meyer, Raquel M; O’Brien-Pallas, Linda L

    2010-01-01

    meyer r.m. & o’brien-pallas l.l. (2010)Nursing services delivery theory: an open system approach. Journal of Advanced Nursing66(12), 2828–2838. Aim This paper is a discussion of the derivation of the Nursing Services Delivery Theory from the application of open system theory to large-scale organizations. Background The underlying mechanisms by which staffing indicators influence outcomes remain under-theorized and unmeasured, resulting in a ‘black box’ that masks the nature and organization of nursing work. Theory linking nursing work, staffing, work environments, and outcomes in different settings is urgently needed to inform management decisions about the allocation of nurse staffing resources in organizations. Data sources A search of CINAHL and Business Source Premier for the years 1980–2008 was conducted using the following terms: theory, models, organization, organizational structure, management, administration, nursing units, and nursing. Seminal works were included. Discussion The healthcare organization is conceptualized as an open system characterized by energy transformation, a dynamic steady state, negative entropy, event cycles, negative feedback, differentiation, integration and coordination, and equifinality. The Nursing Services Delivery Theory proposes that input, throughput, and output factors interact dynamically to influence the global work demands placed on nursing work groups at the point of care in production subsystems. Implications for nursing The Nursing Services Delivery Theory can be applied to varied settings, cultures, and countries and supports the study of multi-level phenomena and cross-level effects. Conclusion The Nursing Services Delivery Theory gives a relational structure for reconciling disparate streams of research related to nursing work, staffing, and work environments. The theory can guide future research and the management of nursing services in large-scale healthcare organizations. PMID:20831573

  15. Stakeholders Assessment of Constraints to Project Delivery in the Nigerian Construction Industry

    Directory of Open Access Journals (Sweden)

    Bruno L. Tanko

    2017-01-01

    Full Text Available The central goal of construction stakeholders is to successfully deliver projects to stated objective (s. However, for decades, construction projects have been plagued by perennial constraints of cost and time overruns, poor quality, and lack of sustainability. The objective of this paper is to identify and assess the constraints to construction project delivery, and to recommend solutions to enhance project performance. This paper adopted both quantitative and qualitative methods to establish the constraints in the Nigerian construction industry. A pilot survey and literature reviewed revealed a total of fifty (50 construction constraints, which were further classified into eight (8 major groups. Well-structured questionnaires were administered to construction stakeholders (client, consultant and contractor in Abuja, the federal capital city of Nigeria. Relative Importance Index (RII was used to analyze the data using Likert scale.  The results suggest that cost/time overrun related factors (inability to reduce project cost, Stakeholders interactive-related factors (inability to establish client value system, Client-related factors (Delay in interim payment and finance problem, and Labor/material-related factors (escalation of material prices and materials quality variability are the most prevalent constraints in the Nigerian construction environment.  To mitigate the effects of these challenges, it is suggested that a formal innovative approach should be used by stakeholders to address the problems of poor communication, high project cost, and delay. Clients should also take measures to provide adequate funding and should promptly honor interim certificates.

  16. How the Project Approach Challenges Young Children

    Science.gov (United States)

    Burns, Marcia V.; Lewis, Alisha L.

    2016-01-01

    In this article, educators at University Primary School in Champaign, Illinois, share examples and understandings of the ways The Project Approach challenges young children to think critically about topics of importance in their world. Project investigations that provoke academic and social challenges for individuals and classroom communities of…

  17. A simple distributed sediment delivery approach for rural catchments

    Science.gov (United States)

    Reid, Lucas; Scherer, Ulrike

    2014-05-01

    The transfer of sediments from source areas to surface waters is a complex process. In process based erosion models sediment input is thus quantified by representing all relevant sub processes such as detachment, transport and deposition of sediment particles along the flow path to the river. A successful application of these models requires, however, a large amount of spatially highly resolved data on physical catchment characteristics, which is only available for a few, well examined small catchments. For the lack of appropriate models, the empirical Universal Soil Loss Equation (USLE) is widely applied to quantify the sediment production in meso to large scale basins. As the USLE provides long-term mean soil loss rates, it is often combined with spatially lumped models to estimate the sediment delivery ratio (SDR). In these models, the SDR is related to data on morphological characteristics of the catchment such as average local relief, drainage density, proportion of depressions or soil texture. Some approaches include the relative distance between sediment source areas and the river channels. However, several studies showed that spatially lumped parameters describing the morphological characteristics are only of limited value to represent the factors of influence on sediment transport at the catchment scale. Sediment delivery is controlled by the location of the sediment source areas in the catchment and the morphology along the flow path to the surface water bodies. This complex interaction of spatially varied physiographic characteristics cannot be adequately represented by lumped morphological parameters. The objective of this study is to develop a simple but spatially distributed approach to quantify the sediment delivery ratio by considering the characteristics of the flow paths in a catchment. We selected a small catchment located in in an intensively cultivated loess region in Southwest Germany as study area for the development of the SDR approach. The

  18. Exploring the knowledge ‘base’ of practitioners in the delivery of sustainable regeneration projects

    Directory of Open Access Journals (Sweden)

    Julius Akotia

    2016-06-01

    Full Text Available In recent years, sustainable regeneration has been recognised as being of major economic and social concern in the world. In the UK for instance, government has initiated a number of policies and evaluation methods to deal with some of the environmental problems associated with regeneration projects. However, the post construction evaluation of these projects has often resulted in them being seen as not achieving their set objectives. Attempts aimed at evaluating the impact of sustainability by built environment practitioners have primarily been limited to their assessment of the projects’ potential environmental impacts, with the associated socio-economic impacts being neglected. There has not been any well-defined built environment research that has been able to deal holistically with the broader issues of sustainability in terms of benefits/impacts of the regeneration projects to the communities concerned. The findings of an exploratory study that adopted a semi-structured interview approach for data collection, to explore the knowledge and understanding of fifteen practitioners who are often involved in the delivery of these projects are presented. The findings reveal a lack of knowledge and understanding of sustainability as well as structured mechanism/practices for evaluating the socio-economic sustainability factors in relation to regeneration projects.

  19. Computational Experiment Study on Selection Mechanism of Project Delivery Method Based on Complex Factors

    Directory of Open Access Journals (Sweden)

    Xiang Ding

    2014-01-01

    Full Text Available Project delivery planning is a key stage used by the project owner (or project investor for organizing design, construction, and other operations in a construction project. The main task in this stage is to select an appropriate project delivery method. In order to analyze different factors affecting the PDM selection, this paper establishes a multiagent model mainly to show how project complexity, governance strength, and market environment affect the project owner’s decision on PDM. Experiment results show that project owner usually choose Design-Build method when the project is very complex within a certain range. Besides, this paper points out that Design-Build method will be the prior choice when the potential contractors develop quickly. This paper provides the owners with methods and suggestions in terms of showing how the factors affect PDM selection, and it may improve the project performance.

  20. Analysis of architect’s performance indicators in project delivery process

    Science.gov (United States)

    Marisa, A.

    2018-03-01

    Architect as a professional in the construction industry should possess a good performance in project delivery process. As a design professional, architect has an important role to ensure that the process is well-conducted by delivering a high-quality product for the clients. Thus, analyzing architect’s performance indicators is crucial in the project delivery process. This study aims to analyze the relative importance of architect performance indicators in project delivery process among registered architects in North Sumatera, Indonesia. A total of five indicators that measure architect performance in project delivery process were identified and 110 completed questionnaires were obtained and used for data analysis. A relative importance index is used to rank the relative importance of architect performance indicators. Results indicate that focus on the clients is the most important indicator of architect performance in project delivery process. This study demonstrates project communication as one of crucial indicators perceived by the architects for measuring their performance, and fills a knowledge gap on the importance of identifying the most important indicator for measuring architect performance from their own perspectives which previous studies have overlooked to improve performance assessment in project delivery process.

  1. West Virginia Peer Exchange : Streamlining Highway Safety Improvement Program Project Delivery - An RSPCB Peer Exchange

    Science.gov (United States)

    2014-09-01

    The West Virginia Division of Highways (WV DOH) hosted a Peer Exchange to share information and experiences for streamlining Highway Safety Improvement Program (HSIP) project delivery. The event was held September 23 to 24, 2014 in Charleston, West V...

  2. West Virginia peer exchange : streamlining highway safety improvement program project delivery.

    Science.gov (United States)

    2015-01-01

    The West Virginia Division of Highways (WV DOH) hosted a Peer Exchange to share information and experiences : for streamlining Highway Safety Improvement Program (HSIP) project delivery. The event was held September : 22 to 23, 2014 in Charleston, We...

  3. Managerial process improvement: a lean approach to eliminating medication delivery.

    Science.gov (United States)

    Hussain, Aftab; Stewart, LaShonda M; Rivers, Patrick A; Munchus, George

    2015-01-01

    Statistical evidence shows that medication errors are a major cause of injuries that concerns all health care oganizations. Despite all the efforts to improve the quality of care, the lack of understanding and inability of management to design a robust system that will strategically target those factors is a major cause of distress. The paper aims to discuss these issues. Achieving optimum organizational performance requires two key variables; work process factors and human performance factors. The approach is that healthcare administrators must take in account both variables in designing a strategy to reduce medication errors. However, strategies that will combat such phenomena require that managers and administrators understand the key factors that are causing medication delivery errors. The authors recommend that healthcare organizations implement the Toyota Production System (TPS) combined with human performance improvement (HPI) methodologies to eliminate medication delivery errors in hospitals. Despite all the efforts to improve the quality of care, there continues to be a lack of understanding and the ability of management to design a robust system that will strategically target those factors associated with medication errors. This paper proposes a solution to an ambiguous workflow process using the TPS combined with the HPI system.

  4. [Pregnancy, delivery and customs: transcultural approach in obstetrics].

    Science.gov (United States)

    Carles, G

    2014-04-01

    Pregnancy and delivery are at the heart of all cultures and ethnic groups, as they assure the continuity of any community. Over the millennia, each society has elaborated a combination of prescriptions, proscriptions and protective rites for future mothers and babies, based on their observations of nature in combination with their religious and mythic convictions. Common to the majority are the vulnerability of the mother-to-be to spirits, and the crucial and symbolic importance of the placenta and the umbilical cord. Delivery in hospital, in spite of its reassurance of greater security, may be an unpleasant experience (to both mother and family) because of the impossibility of respecting traditions. Medical personnel in charge of such culturally uprooted patients should, with the help of cultural mediators, become familiar with a minimum of customs and taboos (of the patient's community) and win the patient's confidence through a respectful approach and an empathetic listening in order to adapt their necessary practices of hygiene and security. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  5. Investigating the Practical Impact of Agile Practices on the Quality of Software Projects in Continuous Delivery

    OpenAIRE

    Olumide Akerele; Muthu Ramachandran; Mark Dixon

    2014-01-01

    Various factors affect the impact of agile factors on the continuous delivery of software projects. This is a major reason why projects perform differently- some failing and some succeeding- when they implement some agile practices in various environments. This is not helped by the fact that many projects work within limited budget while project plans also change-- making them to fall into some sort of pressure to meet deadline when they fall behind in their planned work. This study investiga...

  6. Project Management Approaches for Online Learning Design

    Science.gov (United States)

    Eby, Gulsun; Yuzer, T. Volkan

    2013-01-01

    Developments in online learning and its design are areas that continue to grow in order to enhance students' learning environments and experiences. However, in the implementation of new technologies, the importance of properly and fairly overseeing these courses is often undervalued. "Project Management Approaches for Online Learning Design"…

  7. Caltrans : transit funding manual : managing the delivery of transit projects

    Science.gov (United States)

    2001-05-01

    This manual attempts to provide a step by step transit funding process. Included in this manual : is an overview of Caltrans Division of Mass Transportation, roles and responsibilities in : assisting local agencies to deliver transit projects. Transi...

  8. A novel approach for nucleic acid delivery into cancer cells.

    Science.gov (United States)

    Vainauska, Dace; Kozireva, Svetlana; Karpovs, Andrejs; Čistjakovs, Maksims; Bariševs, Mihails

    2012-01-01

    Liposomal magnetofection is based on the use of superparamagnetic particles and cationic lipids and shows better transfection efficiency than other common nonviral gene delivery methods; however, the distribution of aggregate complexes over the cell surface may be ununiform. The use of a dynamic gradient magnetic field could overcome this limitation. A newly developed device for magnetofection under a dynamic magnetic field was used to compare the transfection efficiency of prostate carcinoma cell line PC3 with that obtained by lipofection and magnetofection. Reporter plasmid pcDNA3.1LacZ DNA was used in combination with Lipofectamine2000 reagent and superparamagnetic nanoparticles CombiMag. The effects of incubation time under a dynamic magnetic field and a rotation frequency of magnets on transfection efficiency for PC3 cell line were determined. Alternatively, lipofection and liposomal magnetofection were carried out. Transfection efficiency of delivery methods was estimated by β-galactosidase staining; cell viability, by acridine orange/ethidium bromide staining. Liposomal magnetofection under a dynamic gradient magnetic field demonstrated the highest transfection efficiency: it was greater by almost 21% and 42% in comparison with liposomal magnetofection and lipofection, respectively. The optimal incubation time under dynamic magnetic field and the optimal magnet rotation frequency were 5 minutes and 5 rpm, respectively. Liposomal magnetofection under a dynamic gradient magnetic field was less cytotoxic (7%) than that under a permanent magnetic field (17%) and lipofection (11%). Our new approach, based on the use of a dynamic gradient magnetic field, enhanced the transfection efficiency and had a less cytotoxic effect on prostate cancer cells in comparison with the standard magnetofection and lipofection.

  9. Combinatorial Approaches for the Identification of Brain Drug Delivery Targets

    Science.gov (United States)

    Stutz, Charles C.; Zhang, Xiaobin; Shusta, Eric V.

    2018-01-01

    The blood-brain barrier (BBB) represents a large obstacle for the treatment of central nervous system diseases. Targeting endogenous nutrient transporters that transcytose the BBB is one promising approach to selectively and noninvasively deliver a drug payload to the brain. The main limitations of the currently employed transcytosing receptors are their ubiquitous expression in the peripheral vasculature and the inherent low levels of transcytosis mediated by such systems. In this review, approaches designed to increase the repertoire of transcytosing receptors which can be targeted for the purpose of drug delivery are discussed. In particular, combinatorial protein libraries can be screened on BBB cells in vitro or in vivo to isolate targeting peptides or antibodies that can trigger transcytosis. Once these targeting reagents are discovered, the cognate BBB transcytosis system can be identified using techniques such as expression cloning or immunoprecipitation coupled with mass spectrometry. Continued technological advances in BBB genomics and proteomics, membrane protein manipulation, and in vitro BBB technology promise to further advance the capability to identify and optimize peptides and antibodies capable of mediating drug transport across the BBB. PMID:23789958

  10. APPROACHES FOR EVALUATING AND FINANCING INVESTMENT PROJECTS

    Directory of Open Access Journals (Sweden)

    MARIA-LOREDANA POPESCU

    2011-04-01

    Full Text Available This article presents the financial investment approach and the investment evaluation methods, which are criteria for assessing both investment projects and their funding sources. An important role in the analysis carried out is played by the investment decision and financing decision quality. Making an investment decision implies computing the related investment efficiency indicators. They allow the comparison of several variants of the same investment project as well as their comparison with other projects in the same industry or in other industries. The financing decision concerns the selection between their own sources (share capital, depreciation fund, profits, reserve funds, additional capital, revenues from investments, attracted sources (domestic resource mobilization and borrowed sources (credits.

  11. 78 FR 53712 - Surface Transportation Project Delivery Program Application Requirements

    Science.gov (United States)

    2013-08-30

    ... application, and discussion of classes of multimodal projects that may be best handled on a case-by-case basis... submissions; a paragraph discussing the joint application process; and a paragraph authorizing the Agencies to... early enough to allow for a joint application of the Secretary's responsibilities before the...

  12. Approaches to nontraditional delivery of nuclear engineering education

    International Nuclear Information System (INIS)

    Malaviya, B.K.

    1991-01-01

    At Rensselaer Polytechnic Institute, the faculty of the nuclear engineering and engineering physics department have, over the years, been involved in a variety of such approaches in response to the changing needs of nuclear industry personnel. A number of different types of short course and workshop programs have been developed and implemented both on and off campus in such areas as basic nuclear technology, reactor design computer codes and applications, nuclear power plant design and maintenance, reactor operations, health physics, modern developments in boiling heat transfer and two-phase flow, and probabilistic risk assessment. Customized coursed tailored to meet the particular needs of personnel in specialized areas can also be offered on specific industrial site locations, generally resulting in substantial savings of time as well as costs associated with tuition, travel, lodging. The Rensselaer Satellite Video Program (RSVP) brings the latest technological aids to the nontraditional delivery of courses and provides the facilities and opportunities for off-campus students and professional personnel to participate in regular academic programs and courses without leaving their industrial sites

  13. Solid effervescent formulations as new approach for topical minoxidil delivery.

    Science.gov (United States)

    Pereira, Maíra N; Schulte, Heidi L; Duarte, Natane; Lima, Eliana M; Sá-Barreto, Livia L; Gratieri, Tais; Gelfuso, Guilherme M; Cunha-Filho, Marcilio S S

    2017-01-01

    Currently marketed minoxidil formulations present inconveniences that range from a grease hard aspect they leave on the hair to more serious adverse reactions as scalp dryness and irritation. In this paper we propose a novel approach for minoxidil sulphate (MXS) delivery based on a solid effervescent formulation. The aim was to investigate whether the particle mechanical movement triggered by effervescence would lead to higher follicle accumulation. Preformulation studies using thermal, spectroscopic and morphological analysis demonstrated the compatibility between effervescent salts and the drug. The effervescent formulation demonstrated a 2.7-fold increase on MXS accumulation into hair follicles casts compared to the MXS solution (22.0±9.7μg/cm 2 versus 8.3±4.0μg/cm 2 ) and a significant drug increase (around 4-fold) in remaining skin (97.1±29.2μg/cm 2 ) compared to the drug solution (23.5±6.1μg/cm 2 ). The effervescent formulations demonstrated a prominent increase of drug permeation highly dependent on the effervescent mixture concentration in the formulation, confirming the hypothesis of effervescent reaction favoring drug penetration. Clinically, therapy effectiveness could be improved, increasing the administration interval, hence, patient compliance. More studies to investigate the follicular targeting potential and safety of new formulations are needed. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. Drug Delivery Approaches for the Treatment of Cervical Cancer

    Directory of Open Access Journals (Sweden)

    Farideh Ordikhani

    2016-07-01

    Full Text Available Cervical cancer is a highly prevalent cancer that affects women around the world. With the availability of new technologies, researchers have increased their efforts to develop new drug delivery systems in cervical cancer chemotherapy. In this review, we summarized some of the recent research in systematic and localized drug delivery systems and compared the advantages and disadvantages of these methods.

  15. Delineating Supply Chain Management (SCM Features in Construction Project Delivery: The Nigerian Case

    Directory of Open Access Journals (Sweden)

    Benedict Amade

    2017-04-01

    Full Text Available This study sought to delineate SCM features using the analytical hierarchy process (AHP with a view to incorporating it into the delivery of construction projects in Nigeria. The study adopted an exploratory research design (quantitative and qualitative methods. A purposive and convenient sampling technique was deployed with the aid of semi-structured interview, case study; questionnaire survey in a construction firm in Port-Harcourt, Rivers State, Nigeria. Questionnaires were used to collect primary data after being pre-tested via a pilot study for validity and reliability. The data collected were analysed using the AHP. Findings from the study shows that the following features are key; Instituting trust and long term relationships amongst supply chain partners (ITP, supply chain finance (SCF, supply chain and continuous performance measurement (SCCPM, information technology (IT, quality management (QM, supply base management (SBM, senior management’s commitment (SMC and supply chain orientation (SCO. In delivering construction projects to success using the SCM approach, adequate attention and emphasis should be accorded to the aforementioned important features in the order they appear as they would aid in effecting the much needed success. It is also expected that the features would further be beneficial to construction firms as it would enable the firms to manage, measure and evaluate the gains ensuing from the deployment of SCM techniques.

  16. Facilitating Value Creation and Delivery in Construction Projects

    DEFF Research Database (Denmark)

    Thyssen, Mikael Hygum; Bonke, Sten

    This thesis is about value creation in the early stages of construction design processes. It has been problem-driven with a specific management concept, the workshop model, as an outset. Essentially the question was; how should construction project design processes be managed with the objective...... awareness about the potential ‘pit-falls’ observed in the case-studies by means of three metaphors for reflection and design-group adjustment. These are: (1) Part-whole conversation, (2) Game of persuasion and (3) Hyper-reality. Reflection and adjustment may require the inclusion of a facilitator....... In addition, concrete suggestions for further development of the design management concept, the workshop model, are provided. In general, the thesis contributes to the emerging literature on construction design man-agement, which is still in its infancy. In addition, the theory part of the thesis contrib...

  17. Hydrologic site characterization - the UMTRA project approach

    International Nuclear Information System (INIS)

    Binkman, J.E.; Hoopes, J.R.

    1985-01-01

    The United States Environmental Protection Agency (EPA) Standards (40 CFR 192) require site characterization of the hydrogeologic regime at and around each Uranium Mill Tailings Remedial Action (UMTRA) Project site. Also, ''judgements on the possible need for remedial or protective actions for groundwater aquifers should be guided by relevant considerations described in EPA's hazardous waste management system (47 CFR 32274).'' To address those two sets of rules and regulations, a generic approach is being developed. Fourteen primary issues were determined. These issues can be grouped into those that can be determined by documentation of available information and present conditions, those that require extensive field investigations and those that require some form of predictive modeling. To address the various issues requires an integrated effort of hydrogeologists, environmental engineers or scientists and health physicists. In this paper, the approach to the resolution of these fourteen issues is described briefly

  18. Double Shell Tanks (DST) and Waste Feed Delivery Project Management Quality Affecting Procedures Management Plan

    International Nuclear Information System (INIS)

    LUND, D.P.

    2000-01-01

    The purpose of the Double Shell Tanks (DST) and Waste Feed Delivery (WFD) Management Assessment Plan is to define how management assessments within DST h WFD will be conducted. The plan as written currently includes only WFD Project assessment topics. Other DST and WFD group assessment topics will be added in future revisions

  19. 75 FR 75532 - Surface Transportation Project Delivery Pilot Program; Caltrans Audit Report

    Science.gov (United States)

    2010-12-03

    ...] Surface Transportation Project Delivery Pilot Program; Caltrans Audit Report AGENCY: Federal Highway... participating in the Pilot Program, 23 U.S.C. 327(g) mandates semiannual audits during each of the first 2 years of State participation. This notice announces and solicits comments on the fifth audit report for the...

  20. 76 FR 5237 - Surface Transportation Project Delivery Pilot Program; Caltrans Audit Report

    Science.gov (United States)

    2011-01-28

    ...] Surface Transportation Project Delivery Pilot Program; Caltrans Audit Report AGENCY: Federal Highway... participating in the Pilot Program, 23 U.S.C. 327(g) mandates semiannual audits during each of the first 2 years of State participation. This final report presents the findings from the fifth FHWA audit of the...

  1. 77 FR 26355 - Surface Transportation Project Delivery Pilot Program; Caltrans Audit Report

    Science.gov (United States)

    2012-05-03

    ...] Surface Transportation Project Delivery Pilot Program; Caltrans Audit Report AGENCY: Federal Highway... participating in the Pilot Program, 23 U.S.C. 327(g) mandates semiannual audits during each of the first 2 years of State participation. This final report presents the findings from the sixth FHWA audit of the...

  2. Quantum canonical ensemble: A projection operator approach

    Science.gov (United States)

    Magnus, Wim; Lemmens, Lucien; Brosens, Fons

    2017-09-01

    Knowing the exact number of particles N, and taking this knowledge into account, the quantum canonical ensemble imposes a constraint on the occupation number operators. The constraint particularly hampers the systematic calculation of the partition function and any relevant thermodynamic expectation value for arbitrary but fixed N. On the other hand, fixing only the average number of particles, one may remove the above constraint and simply factorize the traces in Fock space into traces over single-particle states. As is well known, that would be the strategy of the grand-canonical ensemble which, however, comes with an additional Lagrange multiplier to impose the average number of particles. The appearance of this multiplier can be avoided by invoking a projection operator that enables a constraint-free computation of the partition function and its derived quantities in the canonical ensemble, at the price of an angular or contour integration. Introduced in the recent past to handle various issues related to particle-number projected statistics, the projection operator approach proves beneficial to a wide variety of problems in condensed matter physics for which the canonical ensemble offers a natural and appropriate environment. In this light, we present a systematic treatment of the canonical ensemble that embeds the projection operator into the formalism of second quantization while explicitly fixing N, the very number of particles rather than the average. Being applicable to both bosonic and fermionic systems in arbitrary dimensions, transparent integral representations are provided for the partition function ZN and the Helmholtz free energy FN as well as for two- and four-point correlation functions. The chemical potential is not a Lagrange multiplier regulating the average particle number but can be extracted from FN+1 -FN, as illustrated for a two-dimensional fermion gas.

  3. Comparisons on International Approaches of Business and Project Risk Management

    OpenAIRE

    Nadia Carmen ENE

    2005-01-01

    In this article we intend to present a comparative approach between three recognized international methodologies for risk management: RISKMAN, Project Management Institute Methodology-PMBoK and Project Risk Analysis and Management Guide (produced by Association for Project Management).

  4. An Approach for Implementation of Project Management Information Systems

    Science.gov (United States)

    Běrziša, Solvita; Grabis, Jānis

    Project management is governed by project management methodologies, standards, and other regulatory requirements. This chapter proposes an approach for implementing and configuring project management information systems according to requirements defined by these methodologies. The approach uses a project management specification framework to describe project management methodologies in a standardized manner. This specification is used to automatically configure the project management information system by applying appropriate transformation mechanisms. Development of the standardized framework is based on analysis of typical project management concepts and process and existing XML-based representations of project management. A demonstration example of project management information system's configuration is provided.

  5. Nanoparticle-based drug delivery systems: promising approaches against infections

    Energy Technology Data Exchange (ETDEWEB)

    Ranghar, Shweta; Sirohi, Parul [Department of Applied Mechanics, Motilal Nehru National Institute of Technology, Allahabad (India); Verma, Pritam; Agarwal, Vishnu [Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad (India)

    2014-03-15

    Despite the fact that many new drugs and technologies have been developed to combat the infectious diseases, these have continued to be global health challenges. The use of conventional antimicrobial agents against these infections is always associated with problems such as the development of multiple drug resistance and adverse side effects. In addition, the inefficient traditional drug delivery system results in inadequate therapeutic index, low bioavailability of drugs and many other limitations. In this regard, antimicrobial nanoparticles and nanosized drug delivery carriers have emerged as potent effective agents against the infections. Nanoparticles have unique properties owing to their ultra small and controllable size such as high surface area, enhanced reactivity, and functionalizable structure. This review focused on different classes of antimicrobial nanoparticles, including metal, metal oxide and others along with their mechanism of action and their potential use against the infections. The review also focused on the development of nanoparticle systems for antimicrobial drug delivery and use of these systems for delivery of various antimicrobial agents, giving an overview about modern nanoparticle based therapeutic strategies against the infections. (author)

  6. Nanoparticle-based drug delivery systems: promising approaches against infections

    International Nuclear Information System (INIS)

    Ranghar, Shweta; Sirohi, Parul; Verma, Pritam; Agarwal, Vishnu

    2014-01-01

    Despite the fact that many new drugs and technologies have been developed to combat the infectious diseases, these have continued to be global health challenges. The use of conventional antimicrobial agents against these infections is always associated with problems such as the development of multiple drug resistance and adverse side effects. In addition, the inefficient traditional drug delivery system results in inadequate therapeutic index, low bioavailability of drugs and many other limitations. In this regard, antimicrobial nanoparticles and nanosized drug delivery carriers have emerged as potent effective agents against the infections. Nanoparticles have unique properties owing to their ultra small and controllable size such as high surface area, enhanced reactivity, and functionalizable structure. This review focused on different classes of antimicrobial nanoparticles, including metal, metal oxide and others along with their mechanism of action and their potential use against the infections. The review also focused on the development of nanoparticle systems for antimicrobial drug delivery and use of these systems for delivery of various antimicrobial agents, giving an overview about modern nanoparticle based therapeutic strategies against the infections. (author)

  7. Nursing Services Delivery Theory: an open system approach.

    Science.gov (United States)

    Meyer, Raquel M; O'Brien-Pallas, Linda L

    2010-12-01

    This paper is a discussion of the derivation of the Nursing Services Delivery Theory from the application of open system theory to large-scale organizations. The underlying mechanisms by which staffing indicators influence outcomes remain under-theorized and unmeasured, resulting in a 'black box' that masks the nature and organization of nursing work. Theory linking nursing work, staffing, work environments, and outcomes in different settings is urgently needed to inform management decisions about the allocation of nurse staffing resources in organizations. A search of CINAHL and Business Source Premier for the years 1980-2008 was conducted using the following terms: theory, models, organization, organizational structure, management, administration, nursing units, and nursing. Seminal works were included. The healthcare organization is conceptualized as an open system characterized by energy transformation, a dynamic steady state, negative entropy, event cycles, negative feedback, differentiation, integration and coordination, and equifinality. The Nursing Services Delivery Theory proposes that input, throughput, and output factors interact dynamically to influence the global work demands placed on nursing work groups at the point of care in production subsystems. THE Nursing Services Delivery Theory can be applied to varied settings, cultures, and countries and supports the study of multi-level phenomena and cross-level effects. The Nursing Services Delivery Theory gives a relational structure for reconciling disparate streams of research related to nursing work, staffing, and work environments. The theory can guide future research and the management of nursing services in large-scale healthcare organizations. © 2010 Blackwell Publishing Ltd.

  8. Nuclear outages: an approach to project controls

    International Nuclear Information System (INIS)

    Bryson, R.

    1985-01-01

    The annual budget for maintaining and operating a nuclear power plant has risen dramatically over the past 5 years. NRC-mandated plant improvements and outage related expenses are often cited to be the main contributors to these escalating budgets. Nuclear utilities have responded by developing programs to improve plant availability and outage costs through improved outage performance. Utilities recognize that for capital improvements the program to control costs does no begin with outage planning, but rather more appropriately up front during the engineering phase. To support their management objectives, utilities have been developing comprehensive project control systems for concurrently reducing capital expenditures, outage-related costs, and time. This paper provides an approach to project controls that, rather than using one all inclusive comprehensive system, requires five separate monitoring systems - one for each phase of an activity's life cycle. Through the integration of these discrete but interrelated systems, utility management acquires the necessary tools for comprehensive planning and control of their modification program and effective detailed monitoring for all outage-related activities

  9. The morphological /settlement pattern classification of South African settlements based on a settlement catchment approach, to inform facility allocation and service delivery

    CSIR Research Space (South Africa)

    Sogoni, Z

    2016-07-01

    Full Text Available / settlement pattern classification of South African settlements based on a settlement catchment approach, to inform facility allocation and service delivery Zukisa Sogoni Planning Africa Conference 2016 4 July 2Project Focus and Background • CSIR... services. • Purpose is to support application & planning for new investment & prevent “unsustainable” investments / White elephants. 3Outputs • National set of service delivery catchments • Profile information per individual catchment • Ranking...

  10. Project evaluation: one framework - four approaches

    DEFF Research Database (Denmark)

    Rode, Anna Le Gerstrøm; Svejvig, Per

    . Introducing a framework that can help structure such evaluations, the aim of this paper is to contribute to project theory and practice by inspiring project researchers and aiding project workers in their efforts to open up the black box of projects and deliver relevant and valuable results......There are many theoretical and practical reasons for evaluating projects – including explorative arguments focusing on expanding descriptive knowledge on projects as well as normative arguments focusing on developing prescriptive knowledge of project management. Despite the need for effective...... project management and research methods that can assess effective project management methodologies, extant literature on evaluation procedures or guidelines on how to evaluate projects and/or project management is scarce. To address this challenge, this paper introduces an evaluation framework consisting...

  11. Trevino Project: a fast-track approach for a small construction project

    International Nuclear Information System (INIS)

    Schick, C.J.; Lynn, N.S.

    1982-01-01

    The approach to a construction project can vary according to the size, location, and degree of difficulty associated with the project. This paper deals with one approach that can be taken to a small construction project, the fast-track approach. A small construction project can be defined as a project having less than $20 million capital cost or a project with a low degree of difficulty. This approach is very applicable to in-situ leaching uranium projects, small precious metal operations, etc. The approach to the small project is that of fast-tracking the project in order to minimize the time over which capital expenditure occurs and also to reduce the indirect costs of field expense, construction supplies, construction equipment, etc. In order to fast-track a project it is necessary to do a very precise job on the preliminary phases of the project such as preliminary engineering, plant site location, environmental permits, etc. 2 figures, 2 tables

  12. Combination Drug Delivery Approaches in Metastatic Breast Cancer

    Directory of Open Access Journals (Sweden)

    Jun H. Lee

    2012-01-01

    Full Text Available Disseminated metastatic breast cancer needs aggressive treatment due to its reduced response to anticancer treatment and hence low survival and quality of life. Although in theory a combination drug therapy has advantages over single-agent therapy, no appreciable survival enhancement is generally reported whereas increased toxicity is frequently seen in combination treatment especially in chemotherapy. Currently used combination treatments in metastatic breast cancer will be discussed with their challenges leading to the introduction of novel combination anticancer drug delivery systems that aim to overcome these challenges. Widely studied drug delivery systems such as liposomes, dendrimers, polymeric nanoparticles, and water-soluble polymers can concurrently carry multiple anticancer drugs in one platform. These carriers can provide improved target specificity achieved by passive and/or active targeting mechanisms.

  13. APPLICATION OF PROJECT MANAGEMENT APPROACHES AT A SMALL BUSINESSES ENTERPRISES

    Directory of Open Access Journals (Sweden)

    Sergey V. Rajewski

    2016-01-01

    Full Text Available This article discusses the types of organizational structures of project management and their application in project management in small and medium-sized enterprises. Among the approaches and methods to organize projects emphasizing project management as part of the existing functional structure of the enterprise. Analyzed the most relevant organizational tools of project management in small business: a network schedule; matrix distribution of administrative and management tasks of the project; schedule of the project plan; information and technological methods and models used in the process of project management; software applications for project management, used in the sphere of small business.

  14. Open Source Approach to Project Management Tools

    Directory of Open Access Journals (Sweden)

    Romeo MARGEA

    2011-01-01

    Full Text Available Managing large projects involving different groups of people and complex tasks can be challenging. The solution is to use Project management software, which allows a more efficient management of projects. However, famous project management systems can be costly and may require expensive custom servers. Even if free software is not as complex as Microsoft Project, is noteworthy to think that not all projects need all the features, amenities and power of such systems. There are free and open source software alternatives that meet the needs of most projects, and that allow Web access based on different platforms and locations. A starting stage in adopting an OSS in-house is finding and identifying existing open source solution. In this paper we present an overview of Open Source Project Management Software (OSPMS based on articles, reviews, books and developers’ web sites, about those that seem to be the most popular software in this category.

  15. A Path to Successful Energy Retrofits: Early Collaboration through Integrated Project Delivery Teams

    Energy Technology Data Exchange (ETDEWEB)

    Parrish, Kristen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-10-01

    This document guides you through a process for the early design phases of retrofit projects to help you mitigate frustrations commonly experienced by building owners and designers. It outlines the value of forming an integrated project delivery team and developing a communication and information-sharing infrastructure that fosters collaboration. This guide does not present a complete process for designing an energy retrofit for a building. Instead, it focuses on the early design phase tasks related to developing and selecting energy efficiency measures (EEMs) that benefit from collaboration, and highlights the resulting advantages.

  16. RISK MANAGEMENT APPROACHES AND PRACTICES IN IT PROJECTS

    Directory of Open Access Journals (Sweden)

    BRANDAS Claudiu

    2012-07-01

    Full Text Available Risk is identified in project management literature as an important factor influencing IT projects success, and it is relevant for both academic and practitionersn#8217; communities. The paper presents the past and current approaches to risk management in IT projects. The objective of this paper is to compare the different approaches and relate them to existing practices. Project management literature and practice have brought different approaches to risk management, and as a result, many projects ended in failure. We present how risk management is considered in the literature, and we compare the main two approaches: the evaluation approach and the management approach. The contingency approach does not consider risk management to be a specific process as it is an embedded process in the other project management processes. Then, we present the main practices in risk management. The methodology applied is based on documentary study review and analysis of the concepts used by the literature. We analyzed the literature published between 1978 and 2011 from the main journals for IT project management and found out that the essence of project management is risk management. The risk management practices have a considerable influence on stakeholdersn#8217; perception of project success. But, regardless of the chosen approach, a standard method for identifying, assessing, and responding to risks should be included in any project as this influences the outcome of the project.

  17. The nasal delivery of nanoencapsulated statins – an approach for brain delivery

    Directory of Open Access Journals (Sweden)

    Clementino A

    2016-12-01

    Full Text Available Adryana Clementino,1,2 Mellissa Batger,3 Gabriela Garrastazu,2,3 Michele Pozzoli,3 Elena Del Favero,4 Valeria Rondelli,4 Bianca Gutfilen,5 Thiago Barboza,5 Maria B Sukkar,3 Sergio A L Souza,5 Laura Cantù,4 Fabio Sonvico1,3 1Department of Pharmacy, University of Parma, Parma, Italy; 2National Council for Scientific and Technological Development – CNPq, Brasilia, Brazil; 3Graduate School of Health – Pharmacy, University of Technology Sydney, Ultimo, NSW, Australia; 4Department of Medical Biotechnologies and Translational Medicine, LITA, University of Milan, Segrate, Italy; 5Laboratório de Marcação de Células e Moléculas, Department of Radiology, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Purpose: Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases. However, such effects are extremely elusive via the conventional oral administration. The purpose of the present study was to prepare and characterize the physicochemical properties and the in vivo biodistribution of simvastatin-loaded lecithin/chitosan nanoparticles (SVT-LCNs suitable for nasal administration in view of an improved delivery of the statins to the brain. Materials and methods: Chitosan, lecithin, and different oil excipients were used to prepare nanocapsules loaded with simvastatin. Particle size distribution, surface charge, structure, simvastatin loading and release, and interaction with mucus of nanoparticles were determined. The nanoparticle nasal toxicity was evaluated in vitro using RPMI 2651 nasal cell lines. Finally, in vivo biodistribution was assessed by gamma scintigraphy via Tc99m labeling of the particles. Results: Among the different types of nanoparticles produced, the SVT-LCN_MaiLab showed the most ideal physicochemical characteristics, with small diameter (200 nm, positive surface charge (+48 mV and high encapsulation

  18. A Topic-Driven Modular Approach to Engineering Education Delivery

    Directory of Open Access Journals (Sweden)

    Ruba Akram Amarin

    2013-03-01

    Full Text Available The interactive technical electronic book, TechEBook, currently under development at the University of Central Florida, provides a useful tool for engineers and scientists through unique features compared to the most used traditional electrical circuit textbooks available in the market. TechEBook has comprised the two worlds of classical circuit books and an interactive operating platform that can be run on mobile devices, laptops and desktops utilizing Java Virtual Machine operator. The TechEBook provides an interactive applets screen that holds many modules, in which each had a specific application in the self learning process. In this paper the main goals and objectives behind the MeLearning concept will be identified. The paper will describe the differences between the traditional curriculum delivery and the MeLearning concept in details accompanied by the main tools used and a description of the different modules features.

  19. Trends in Rural Water Supply: Towards a Service Delivery Approach

    Directory of Open Access Journals (Sweden)

    Patrick Moriarty

    2013-10-01

    The papers in this special issue argue that tackling these challenges requires a shift in emphasis in rural water supply in developing countries: away from a de-facto focus on the provision of hardware for first-time access towards the proper use of installed hardware as the basis for universal access to rural water services. The outline of the main actions required to achieve this shift are becoming clearer. Chief amongst these are the professionalisation of community management and/or provision of direct support to community service providers; adoption of a wider range of service delivery models than community management alone; and addressing the sustainable financing of all costs with a particular focus on financing capital maintenance (asset management and direct support costs. This introductory paper provides an overview of these issues and a guide to the other articles, which demonstrate these points.

  20. A new approach in gastroretentive drug delivery system using cholestyramine.

    Science.gov (United States)

    Umamaheshwari, R B; Jain, Subheet; Jain, N K

    2003-01-01

    We prepared cellulose acetate butyrate (CAB)-coated cholestyramine microcapsules as a intragastric floating drug delivery system endowed with floating ability due to the carbon dioxide generation when exposed to the gastric fluid. The microcapsules also have a mucoadhesive property. Ion-exchange resin particles can be loaded with bicarbonate followed by acetohydroxamic acid (AHA) and coated with CAB by emulsion solvent evaporation method. The drug concentration was monitored to maintain the floating property and minimum effective concentration. The effect of CAB: drug-resin ratio (2:1, 4:1, 6:1 w/w) on the particle size, floating time, and drug release was determined. Cholestyramine microcapsules were characterized for shape, surface characteristics, and size distribution; cholestyramine/acetohydroxamic acid interactions inside microcapsules were investigated by X-ray diffractometry. The buoyancy time of CAB-coated formulations was better than that of uncoated resin particles. Also, a longer floating time was observed with a higher polymer:drug resin complex ratio (6:1). With increasing coating thickness the particle size was increased but drug release rate was decreased. The drug release rate was higher in simulated gastric fluid (SGF) than in simulated intestinal fluid (SIF). The in vivo mucoadhesion studies were performed with rhodamine-isothiocyanate (RITC) by fluorescent probe method. The amount of CAB-coated cholestyramine microcapsules that remained in the stomach was slightly lower than that of uncoated resin particles. Cholestyramine microcapsules were distributed throughout the stomach and exhibited prolonged gastric residence via mucoadhesion. These results suggest that CAB-coated microcapsules could be a floating as well as a mucoadhesive drug delivery system. Thus, it has promise in the treatment of Helicobacter pylori.

  1. Chronotherapeutic drug delivery systems: an approach to circadian rhythms diseases.

    Science.gov (United States)

    Sunil, S A; Srikanth, M V; Rao, N Sreenivasa; Uhumwangho, M U; Latha, K; Murthy, K V Ramana

    2011-11-01

    The purpose of writing this review on chronotherapeutic drug delivery systems (ChrDDs) is to review the literatures with special focus on ChrDDs and the various dosage forms, techniques that are used to target the circadian rhythms (CR) of various diseases. Many functions of the human body vary considerably in a day. ChrDDs refers to a treatment method in which in vivo drug availability is timed to match circadian rhythms of disease in order to optimize therapeutic outcomes and minimize side effects. Several techniques have been developed but not many dosage forms for all the diseases are available in the market. ChrDDs are gaining importance in the field of pharmaceutical technology as these systems reduce dosing frequency, toxicity and deliver the drug that matches the CR of that particular disease when the symptoms are maximum to worse. Finally, the ultimate benefit goes to the patient due the compliance and convenience of the dosage form. Some diseases that follow circadian rhythms include cardiovascular diseases, asthma, arthritis, ulcers, diabetes etc. ChrDDs in the market were also discussed and the current technologies used to formulate were also stated. These technologies include Contin® , Chronotopic®, Pulsincaps®, Ceform®, Timerx®, Oros®, Codas®, Diffucaps®, Egalet®, Tablet in capsule device, Core-in-cup tablet technology. A coated drug-core tablet matrix, A bi-layered tablet, Multiparticulate-based chronotherapeutic drug delivery systems, Chronoset and Controlled release microchips.

  2. Care for a Patient With Cancer As a Project: Management of Complex Task Interdependence in Cancer Care Delivery.

    Science.gov (United States)

    Trosman, Julia R; Carlos, Ruth C; Simon, Melissa A; Madden, Debra L; Gradishar, William J; Benson, Al B; Rapkin, Bruce D; Weiss, Elisa S; Gareen, Ilana F; Wagner, Lynne I; Khan, Seema A; Bunce, Mikele M; Small, Art; Weldon, Christine B

    2016-11-01

    Cancer care is highly complex and suffers from fragmentation and lack of coordination across provider specialties and clinical domains. As a result, patients often find that they must coordinate care on their own. Coordinated delivery teams may address these challenges and improve quality of cancer care. Task interdependence is a core principle of rigorous teamwork and is essential to addressing the complexity of cancer care, which is highly interdependent across specialties and modalities. We examined challenges faced by a patient with early-stage breast cancer that resulted from difficulties in understanding and managing task interdependence across clinical domains involved in this patient's care. We used team science supported by the project management discipline to discuss how various task interdependence aspects can be recognized, deliberately designed, and systematically managed to prevent care breakdowns. This case highlights how effective task interdependence management facilitated by project management methods could markedly improve the course of a patient's care. This work informs efforts of cancer centers and practices to redesign cancer care delivery through innovative, practical, and patient-centered approaches to management of task interdependence in cancer care. Future patient-reported outcomes research will help to determine optimal ways to engage patients, including those who are medically underserved, in managing task interdependence in their own care.

  3. Experiences of operational costs of HPV vaccine delivery strategies in Gavi-supported demonstration projects

    Science.gov (United States)

    Holroyd, Taylor; Nanda, Shreya; Bloem, Paul; Griffiths, Ulla K.; Sidibe, Anissa; Hutubessy, Raymond C. W.

    2017-01-01

    From 2012 to 2016, Gavi, the Vaccine Alliance, provided support for countries to conduct small-scale demonstration projects for the introduction of the human papillomavirus vaccine, with the aim of determining which human papillomavirus vaccine delivery strategies might be effective and sustainable upon national scale-up. This study reports on the operational costs and cost determinants of different vaccination delivery strategies within these projects across twelve countries using a standardized micro-costing tool. The World Health Organization Cervical Cancer Prevention and Control Costing Tool was used to collect costing data, which were then aggregated and analyzed to assess the costs and cost determinants of vaccination. Across the one-year demonstration projects, the average economic and financial costs per dose amounted to US$19.98 (standard deviation ±12.5) and US$8.74 (standard deviation ±5.8), respectively. The greatest activities representing the greatest share of financial costs were social mobilization at approximately 30% (range, 6–67%) and service delivery at about 25% (range, 3–46%). Districts implemented varying combinations of school-based, facility-based, or outreach delivery strategies and experienced wide variation in vaccine coverage, drop-out rates, and service delivery costs, including transportation costs and per diems. Size of target population, number of students per school, and average length of time to reach an outreach post influenced cost per dose. Although the operational costs from demonstration projects are much higher than those of other routine vaccine immunization programs, findings from our analysis suggest that HPV vaccination operational costs will decrease substantially for national introduction. Vaccination costs may be decreased further by annual vaccination, high initial investment in social mobilization, or introducing/strengthening school health programs. Our analysis shows that drivers of cost are dependent on

  4. The STAR project: context, objectives and approaches

    NARCIS (Netherlands)

    Furse, M.; Hering, D.; Moog, O.; Verdonschot, P.F.M.; Johnson, R.K.; Brabec, K.; Gritzalis, K.; Buffagni, A.; Pinto, P.; Friberg, N.; Murray-Bligh, J.; Kokes, J.; Alber, R.; Usseglio-Polatera, P.; Haase, P.; Sweeting, R.; Bis, B.; Szoszkiewicz, K.; Soszka, H.; Springe, G.; Sporka, F.; Krno, I.

    2006-01-01

    STAR is a European Commission Framework V project (EVK1-CT-2001-00089). The project aim is to provide practical advice and solutions with regard to many of the issues associated with the Water Framework Directive. This paper provides a context for the STAR research programme through a review of the

  5. Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy.

    Science.gov (United States)

    Parhi, Priyambada; Mohanty, Chandana; Sahoo, Sanjeeb Kumar

    2012-09-01

    Combination therapy for the treatment of cancer is becoming more popular because it generates synergistic anticancer effects, reduces individual drug-related toxicity and suppresses multi-drug resistance through different mechanisms of action. In recent years, nanotechnology-based combination drug delivery to tumor tissues has emerged as an effective strategy by overcoming many biological, biophysical and biomedical barriers that the body stages against successful delivery of anticancer drugs. The sustained, controlled and targeted delivery of chemotherapeutic drugs in a combination approach enhanced therapeutic anticancer effects with reduced drug-associated side effects. In this article, we have reviewed the scope of various nanotechnology-based combination drug delivery approaches and also summarized the current perspective and challenges facing the successful treatment of cancer. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. APPLICATION OF PROJECT MANAGEMENT APPROACHES AT A SMALL BUSINESSES ENTERPRISES

    OpenAIRE

    Sergey V. Rajewski

    2016-01-01

    This article discusses the types of organizational structures of project management and their application in project management in small and medium-sized enterprises. Among the approaches and methods to organize projects emphasizing project management as part of the existing functional structure of the enterprise. Analyzed the most relevant organizational tools of project management in small business: a network schedule; matrix distribution of administrative and management tasks of the projec...

  7. Investigation of the Relationship between Green Design and Project Delivery Methods

    Energy Technology Data Exchange (ETDEWEB)

    Bilec, Melissa M.; Ries, Robert J.

    2008-04-24

    The selection of the project delivery method (PDM) for any project is critical--it establishes communication, coordination, and contractual issues between the owner, contractor, and designer. With an increase in the number of green design projects, understanding the relationship between the PDM and green design is paramount to project and contract management. It is reasonable to assume that a positive relationship between green design and design-build (DB) exists since both theoretically are intended to foster an integrated, holistic, and collaborative project. This research examines the relationship between the design-bid-build (DBB), construction management (CM), and DB PDMs and green design with the goal of establishing best practices and identifying potential synergies between them. The research collected information by conducting primarily telephone interviews with approximately twenty-five individuals, including owners, contractors, and designers involved in completed green design projects, mainly in the public sector. The interviews developed a general understanding of the current state of knowledge and experience and not a rigorous quantitative analysis. Upon completion of the interviews, the tabulated results were summarized and green project characteristics and project-PDM interactions emerged. Existing published research was evaluated to reveal aspects of PDMs independent of green design. Best practices were ascertained by combining information from the interviews and published research. Best practices are as follows: (1) Project implementation features--The decision to use DB as PDM on green design or other projects should be based on the specific project features; e.g., well-defined scope and adequate owner staffing. DB will not produce successful results on all projects. (2) Collaboration--Project team collaboration early in the design and construction process is an important aspect of green projects, and collaboration was considered somewhat more

  8. New approaches to targeted drug delivery to tumour cells

    International Nuclear Information System (INIS)

    Severin, E S

    2015-01-01

    Basic approaches to the design of targeted drugs for the treatment of human malignant tumours have been considered. The stages of the development of these approaches have been described in detail and theoretically substantiated, and basic experimental results have been reported. Considerable attention is paid to the general characteristic of nanopharmacological drugs and to the description of mechanisms of cellular interactions with nanodrugs. The potentialities and limitations of application of nanodrugs for cancer therapy and treatment of other diseases have been considered. The use of nanodrugs conjugated with vector molecules seems to be the most promising trend of targeted therapy of malignant tumours. The bibliography includes 122 references

  9. Stakeholder approach for evaluating organizational change projects.

    Science.gov (United States)

    Peltokorpi, Antti; Alho, Antti; Kujala, Jaakko; Aitamurto, Johanna; Parvinen, Petri

    2008-01-01

    This paper aims to create a model for evaluating organizational change initiatives from a stakeholder resistance viewpoint. The paper presents a model to evaluate change projects and their expected benefits. Factors affecting the challenge to implement change were defined based on stakeholder theory literature. The authors test the model's practical validity for screening change initiatives to improve operating room productivity. Change initiatives can be evaluated using six factors: the effect of the planned intervention on stakeholders' actions and position; stakeholders' capability to influence the project's implementation; motivation to participate; capability to change; change complexity; and management capability. The presented model's generalizability should be explored by filtering presented factors through a larger number of historical cases operating in different healthcare contexts. The link between stakeholders, the change challenge and the outcomes of change projects needs to be empirically tested. The proposed model can be used to prioritize change projects, manage stakeholder resistance and establish a better organizational and professional competence for managing healthcare organization change projects. New insights into existing stakeholder-related understanding of change project successes are provided.

  10. [Optimum approach to delivery for control of premature birth (author's transl)].

    Science.gov (United States)

    Nieder, J; Lattorff, E

    1980-01-01

    Foetal condition and neonatal mortality of 637 prematurely born children with birth weights below 2,501 g were analysed, depending on modes of delivery, such as spontaneous birth, speculum delivery, use of forceps, manual support, and caesarean section. The clinical condition of the newborn, assessed five minutes from parturition by Apgar score 1, was found to depend primarily on birth weight rather than on the mode of delivery. The average Apgar values were lower for less mature newborns. While Apgar scores were worst for newborns after caesarean section delivery, the differences between approaches to delivery could not be statistically secured. Neonatal mortality went up, according to expectation, along with dropping birth weight. The mortality rate of premature births below 1,501 g was not affected by delivery modes. Prophylactic use of Shute forceps and speculum delivery appeared to be superior to spontaneous birth in the medium weight class, between 1,501 g and 2,000 g. Yet, not even here were the differences between clear postnatal mortality rates statistically secured. -Lowest mortality figures were recorded from spontaneous birth in the weight class between 2,001 g and 2,500 g, but significant differences were established only to speculum delivery. Premature newborns after caesarean section had poorer prospects than all variants of vaginal birth, but among the latter premature births from breech presentation were more endangered than others. Decisions as to vaginal, abdominal, spontaneous proprophylactically surgical approaches to premature deliveries should be taken for every individual case and due consideration of many factors.

  11. A Comparison of MOOC Development and Delivery Approaches

    Science.gov (United States)

    Smith, Neil; Caldwell, Helen; Richards, Mike; Bandara, Arosha

    2017-01-01

    Purpose: The purpose of this paper is to present a comparison of two ways of developing and delivering massive open online courses (MOOCs). One was developed by The Open University in collaboration with FutureLearn; the other was developed independently by a small team at the Northampton University. Design/methodology/approach: The different…

  12. Systems approach for design control at Monitored Retrievable Storage Project

    International Nuclear Information System (INIS)

    Kumar, P.N.; Williams, J.R.

    1994-01-01

    This paper describes the systems approach in establishing design control for the Monitored Retrievable Storage Project design development. Key elements in design control are enumerated and systems engineering aspects are detailed. Application of lessons learned from the Yucca Mountain Project experience is addressed. An integrated approach combining quality assurance and systems engineering requirements is suggested to practice effective design control

  13. A constructivist approach to communication and projection

    DEFF Research Database (Denmark)

    Skytte, Hans

    In connection with a study on relationships between food producers and retail chains a new theory on communication and projection was developed. To position the new theory the paper first gives a short presentation of the traditional communication theory. Then there is a short presentation...... of the paradigm including the research strategy used for the development of the new theory. Following that you will find a section concerning the conceptual framework used for the analysis of the companies. This section is followed by a discussion of the main results and the new communication and projection...

  14. A Communications Approach to Teaching Project Management

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    2012-01-01

    in the Bachelor of Marketing and Management Communication at Aarhus University is examined and analyzed. The presence of the three Design Science Research Cycles combined with both process and product, highlights the critical role of communication in both understanding Project Management and applying Design...... to both frame the learners’ audience for Project Management Writing assignments, and to provide a concrete organizational context to aid in communication practices such as stakeholder analysis, and the development of a critical internal monitor for quality in the learner’s mind. The relevance of Design...

  15. Study on Risk Approaches in Software Development Projects

    Directory of Open Access Journals (Sweden)

    Claudiu BRANDAS

    2012-01-01

    Full Text Available Risk approaches in project development led to the integration in the IT project management methodologies and software development of activities and processes of risk management. The diversity and the advanced level of the used technologies in IT projects with increasing com-plexity leads to an exponential diversification of risk factors.The purpose of this research is to identify the level of the risk approach in IT projects both at the IT project management and software development methodologies level and the level of the perception of IT project man-agers, IT managers and IT analysts in Romanian IT companies. Thus, we want to determine the correlation between the use of a project management or software development methodology and the overall level of risk perceived by the project managers using these methodologies.

  16. Learning analytics approach of EMMA project

    NARCIS (Netherlands)

    Tammets, Kairit; Brouns, Francis

    2014-01-01

    The EMMA project provides a MOOC platform to aggregate and delivers massive open online courses (MOOC) in multiple languages from a variety of European universities. Learning analytics play an important role in MOOCs to support the individual needs of the learner.

  17. Learning from project experiences using a legacy-based approach

    Science.gov (United States)

    Cooper, Lynne P.; Majchrzak, Ann; Faraj, Samer

    2005-01-01

    As project teams become used more widely, the question of how to capitalize on the knowledge learned in project teams remains an open issue. Using previous research on shared cognition in groups, an approach to promoting post-project learning was developed. This Legacy Review concept was tested on four in tact project teams. The results from those test sessions were used to develop a model of team learning via group cognitive processes. The model and supporting propositions are presented.

  18. Matrix approach for the design of service delivery systems

    Directory of Open Access Journals (Sweden)

    Dina Davis-Castro

    2017-04-01

    Full Text Available The gradual change that is occurring from a purely functional approach to one of process, is conditioned from outside and from within organizations. The world changes faster, from one to the next decade. The politic-economic, social and technological conditions of the first half of the 20th century in the world in general, and in Latin America in particular, are far from the last 50 years of the 20th century. The number of changes that have occurred in the first 15 years of the 21st century is also immeasurable. There is a close relationship between the speed of technological change and changes in a good measure socioeconomic.  It leads to uncertain ways of planning the organizations.  Insofar as the cycles innovation - development are shortened, there is a gap between the appearance of products with superior performance in the market and the duration of similar goods previously acquired by users. This phenomenon shows a trend in the behavior of customers. Clients tends to request services solutions, rather than on specific products.  This essay examines some of the phenomena that affect the design of processes of services with a matrix approach, Result of research carried out in this field.

  19. Public Private Partnerships: A possible alternative for delivery of infrastructure projects in Africa

    Directory of Open Access Journals (Sweden)

    Salim Bwanali

    2017-12-01

    Full Text Available It is estimated that Africa needs $93 billion annually until 2020 in order to bridge its infrastructure deficit. It is through significant investment in infrastructure development that economic growth and poverty alleviation can be enhanced. However central to all construction projects is an effective and sustainable procurement system. There is a notable shift by some African governments to turn to the private sector to design, build, finance and operate infrastructure facilities previously provided by the public sector in the form of Public Private Partnerships (PPP’s. As an innovative financing model, PPPs present an opportunity to governments to improve service delivery. Accordingly, this paper focuses on assessing international best practices as to how some developing nations tap into the resources of the private sector in implementing their infrastructure projects. The study is a result of critical review, synthesis and contextualization of relevant academic literature, conference and journal publications. A thorough document review method was employed to assess how some developing countries have institutionalized PPP as part of their development strategy. The paper will be of significant value to senior government officials as understanding the concept and dynamics of PPP will result in accelerated and effective service delivery.

  20. Project management a systems approach to planning, scheduling, and controlling

    CERN Document Server

    Kerzner, Harold

    2013-01-01

    The bestselling project management text for students andprofessionals-now updated and expanded This Eleventh Edition of the bestselling "bible" ofproject management maintains the streamlined approach of the prioreditions and moves the content even closer to PMI's ProjectManagement Body of Knowledge (PMBOK). New content has been added tothis edition on measuring project management ROI, value to theorganization and to customers, and much more. The capstone "super"case on the "Iridium Project" has been maintained, covering allaspects of project management. Increased use of sidebars throughoutthe book helps further align it with the PMBOK and the ProjectManagement Professional (PMP) Certification Exam. This new edition features significant expansion, including morethan three dozen entirely new sections and updates on processsupporting; types of project closure; project sponsorship; andculture, teamwork, and trust. This comprehensive guide to theprinciples and practices of project management: Offers new sections...

  1. Preventing Elder Abuse: The Texas Plan for a Coordinated Service Delivery System. Collaborative Elder Abuse Prevention Project.

    Science.gov (United States)

    McDaniel, Garry L.

    The Texas Department of Human Services, in collaboration with 13 other public and private organizations, co-sponsored a statewide Collaborative Elder Abuse Prevention project. The goal of this project is to develop a comprehensive, long-range plan for the prevention of elder abuse, a method for achieving a coordinated service delivery system for…

  2. Improving efficiency and safety in external beam radiation therapy treatment delivery using a Kaizen approach.

    Science.gov (United States)

    Kapur, Ajay; Adair, Nilda; O'Brien, Mildred; Naparstek, Nikoleta; Cangelosi, Thomas; Zuvic, Petrina; Joseph, Sherin; Meier, Jason; Bloom, Beatrice; Potters, Louis

    Modern external beam radiation therapy treatment delivery processes potentially increase the number of tasks to be performed by therapists and thus opportunities for errors, yet the need to treat a large number of patients daily requires a balanced allocation of time per treatment slot. The goal of this work was to streamline the underlying workflow in such time-interval constrained processes to enhance both execution efficiency and active safety surveillance using a Kaizen approach. A Kaizen project was initiated by mapping the workflow within each treatment slot for 3 Varian TrueBeam linear accelerators. More than 90 steps were identified, and average execution times for each were measured. The time-consuming steps were stratified into a 2 × 2 matrix arranged by potential workflow improvement versus the level of corrective effort required. A work plan was created to launch initiatives with high potential for workflow improvement but modest effort to implement. Time spent on safety surveillance and average durations of treatment slots were used to assess corresponding workflow improvements. Three initiatives were implemented to mitigate unnecessary therapist motion, overprocessing of data, and wait time for data transfer defects, respectively. A fourth initiative was implemented to make the division of labor by treating therapists as well as peer review more explicit. The average duration of treatment slots reduced by 6.7% in the 9 months following implementation of the initiatives (P = .001). A reduction of 21% in duration of treatment slots was observed on 1 of the machines (P Kaizen approach has the potential to improve operational efficiency and safety with quick turnaround in radiation therapy practice by addressing non-value-adding steps characteristic of individual department workflows. Higher effort opportunities are identified to guide continual downstream quality improvements. Copyright © 2017 American Society for Radiation Oncology. Published by

  3. A Project Management Approach to Using Simulation for Cost Estimation on Large, Complex Software Development Projects

    Science.gov (United States)

    Mizell, Carolyn; Malone, Linda

    2007-01-01

    It is very difficult for project managers to develop accurate cost and schedule estimates for large, complex software development projects. None of the approaches or tools available today can estimate the true cost of software with any high degree of accuracy early in a project. This paper provides an approach that utilizes a software development process simulation model that considers and conveys the level of uncertainty that exists when developing an initial estimate. A NASA project will be analyzed using simulation and data from the Software Engineering Laboratory to show the benefits of such an approach.

  4. Accelerating the Whiteshell Laboratories Decommissioning Through the Implementation of a Projectized and Delivery-Focused Organization - 13074

    Energy Technology Data Exchange (ETDEWEB)

    Wilcox, Brian; Mellor, Russ; Michaluk, Craig [Atomic Energy of Canada Limited, Whiteshell Laboratories, Pinawa, Manitoba (Canada)

    2013-07-01

    and positive impacts on schedule and delivery. A revised organizational structure was implemented in two phases, starting 2011 April 1, to align WL staff with the common goal of decommissioning the site through the direction of the WL Decommissioning Project General Manager. On 2011 September 1, the second phase of the reorganization was implemented and WL Decommissioning staff was organized under five Divisions: Programs and Regulatory Compliance, General Site Services, Decommissioning Strategic Planning, Nuclear Facilities and Project Delivery. A new Mission, Vision and Objectives were developed for the project, and several productivity enhancements are being implemented. These include the use of an integrated and fully re-sourced Site Wide Schedule that is updated and reviewed at Plan-of-the-Week meetings, improved work distribution throughout the year, eliminating scheduling 'push' mentality, project scoreboards, work planning implementation, lean practices and various process improvement initiatives. A revised Strategic Plan is under development that reflects the improved project delivery capabilities. As a result of these initiatives, and a culture change towards a projectized approach, the decommissioning schedule will be advanced by approximately 10 years. (authors)

  5. Project management a systems approach to planning, scheduling, and controlling

    CERN Document Server

    Kerzner, Harold

    2017-01-01

    Project Management is the bestselling text for students and professionals, presenting a streamlined approach to project management functions in full alignment with PMI(r)'s latest Project Management Body of Knowledge (PMBOK(r)). This new 12th edition has been updated to reflect the latest changes found in the PMBOK(r) Guide--Sixth Edition, and features new coverage of emerging topics including global stakeholder management, causes of failure, agile project management, project governance failure, customer approval milestones, classifying project metrics, and more. Supplementary materials are available for students, working professionals, and instructors. * Understand organizational structures and project management functions * Learn how to control costs, manage risk, and analyze trade-offs * Examine different methods used for planning, scheduling, QA, and more * Work effectively with customers and stakeholders from around the globe Project Management is the comprehensive reference to keep within arm's reach. ...

  6. Integration of case study approach, project design and computer ...

    African Journals Online (AJOL)

    Integration of case study approach, project design and computer modeling in managerial accounting education ... Journal of Fundamental and Applied Sciences ... in the Laboratory of Management Accounting and Controlling Systems at the ...

  7. A Universal Design Approach to Government Service Delivery: The Case of ChileAtiende.

    Science.gov (United States)

    Sandoval, Leonardo

    2016-01-01

    A common challenge for government administrations that aim to improve the delivery of information and services to citizens is to go beyond a government-centred approach. By focusing on citizens and the needs of a wide range of citizens, Universal Design (UD) can help to increase the effectiveness, efficiency and satisfaction of government services. This paper examines the case of an internationally recognised Chilean government service delivery programme inspired by UD principles known as ChileAtiende ("ChileService"). A brief account of its creation and current status is provided.

  8. Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery

    Czech Academy of Sciences Publication Activity Database

    Kejík, Z.; Bříza, T.; Králová, Jarmila; Poučková, P.; Kral, A.; Martásek, P.; Král, V.

    2011-01-01

    Roč. 21, č. 18 (2011), s. 5514-5520 ISSN 0960-894X R&D Projects: GA ČR GA203/09/1311 Grant - others:MPO(CZ) FR-TI3/521; AV ČR(CZ) KAN200100801 Program:FR; KA Institutional research plan: CEZ:AV0Z50520514 Keywords : combined cancer therapy * photodynamic therapy * targeted drug delivery Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.554, year: 2011

  9. Incentive Structure of Financing a Project: An Islamic Finance Approach

    OpenAIRE

    Lone, Fayaz Ahmad; Quadir, Abdul

    2017-01-01

    Financing is an important component in any project. Without finance, it is impossible to run any project as it is considered the lifeblood of the business. But due to the presence of predetermined rate of interest, economists have provided alternative approach for financing the project. In this paper a model using Profit and Loss Sharing (PLS) system and comparison of it with the conventional financing model is developed. Thrust in this paper is towards establishing a new theoretical reasonin...

  10. Colon-targeted oral drug delivery systems: design trends and approaches.

    Science.gov (United States)

    Amidon, Seth; Brown, Jack E; Dave, Vivek S

    2015-08-01

    Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn's disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions. Drugs such as proteins and peptides that are known to degrade in the extreme gastric pH, if delivered to the colon intact, can be systemically absorbed by colonic mucosa. In order to achieve effective therapeutic outcomes, it is imperative that the designed delivery system specifically targets the drugs into the colon. Several formulation approaches have been explored in the development colon-targeted drug delivery systems. These approaches involve the use of formulation components that interact with one or more aspects of gastrointestinal (GI) physiology, such as the difference in the pH along the GI tract, the presence of colonic microflora, and enzymes, to achieve colon targeting. This article highlights the factors influencing colon-specific drug delivery and colonic bioavailability, and the limitations associated with CDDS. Further, the review provides a systematic discussion of various conventional, as well as relatively newer formulation approaches/technologies currently being utilized for the development of CDDS.

  11. An Overview On Various Approaches And Recent Patents On Gastroretentive Drug Delivery Systems.

    Science.gov (United States)

    Kumar, Manoj; Kaushik, Deepak

    2018-03-08

    Drugs having absorption window in the stomach or upper small intestine has restricted bioavailability with conventional dosage forms. The gastric residence time of these dosage forms is usually short and they do not show drug release for prolonged period of time. To avoid these problems and to enhance the bioavailability and gastric retention time of these drugs, controlled drug delivery systems with prolonged gastric retention time are currently being developed. This review highlights the various pharmaceutical approaches for gastroretention such as floating drug delivery systems, mucoadhesive systems, high density systems, expandable and swelling systems, superporous hydrogels systems, magnetic systems, ion exchange resin system and recent patents filed or granted for these approaches. Recently some patents are also reported where a combination of various approaches are being employed to achieve very effective gastroretention. The various patent search sites were used to collect and analyze the information on gastroretentive drug delivery systems. The present study provides valuable information, advantages, limitations and future outlook of various gastroretentive drug delivery systems. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  12. Regional Integrated Silvopastoral Approaches to Ecosystem Management Project

    OpenAIRE

    CIPAV (Centre For Research on Sustainable Agricultural Production Systems); CATIE (Centro Agronomico Tropical de Investigacion y Ensenanza); NITLAPAN

    2007-01-01

    Metadata only record The Regional Integrated Silvopastoral Approaches to Ecosystem Management Project introduces the payment for environmental services approach to silvopastoral farmers in Colombia, Costa Rica, and Nicaragua. The objectives of the project are to "demonstrate and measure a) the effects the introduction of payment incentives for environmental services to farmers on their adoption of integrated silvopastoral farming systems in degraded pasture lands; and b) the resulting impr...

  13. Approaches to Teaching Plant Nutrition. Children's Learning in Science Project.

    Science.gov (United States)

    Leeds Univ. (England). Centre for Studies in Science and Mathematics Education.

    During the period 1984-1986, over 30 teachers from the Yorkshire (England) region have worked in collaboration with the Children's Learning in Science Project (CLIS) developing and testing teaching schemes in the areas of energy, particle theory, and plant nutrition. The project is based upon the constructivist approach to teaching. This document…

  14. A Project-based Learning approach for teaching Robotics to ...

    African Journals Online (AJOL)

    In this research we used a project-based learning approach to teach robotics basics to undergraduate business computing students. The course coverage includes basic electronics, robot construction and programming using arduino. Students developed and tested a robot prototype. The project was evaluated using a ...

  15. Digital Modeling, Integrated Project Delivery and Industry Transformation: An Australian Case Study

    Directory of Open Access Journals (Sweden)

    Judy A. Kraatz

    2014-09-01

    Full Text Available This research is focused on realizing productivity benefits for the delivery of transport infrastructure in the Australian construction industry through the use of building information modeling (BIM, virtual design and construction (VDC and integrated project delivery (IPD. Specific objectives include: (I building an understanding of the institutional environment, business systems and support mechanisms (e.g., training and skilling which impact on the uptake of BIM/VDC; (II gathering data to undertake a cross-country analysis of these environments; and (III providing strategic and practical outcomes to guide the uptake of such processes in Australia. Activities which will inform this research include a review of academic literature and industry documentation, semi-formal interviews in Australia and Sweden, and a cross-country comparative analysis to determine factors affecting uptake and associated productivity improvements. These activities will seek to highlight the gaps between current-practice and best-practice which are impacting on widespread adoption of BIM/VDC and IPD. Early findings will be discussed with intended outcomes of this research being used to: inform a national public procurement strategy; provide guidelines for new contractual frameworks; and contribute to closing skill gaps.

  16. Project approach study for nuclear power plants in the Netherlands

    International Nuclear Information System (INIS)

    1985-11-01

    The new nuclear program in the Netherlands comprises the construction of two to four nuclear power plants up to the year 2000. The main objective pursued with the implementation of the nuclear program is the supply of low-cost electricity in the future. In order to prepare the program and to provide a basis for further decisions, the Ministry of Economic Affairs has entrusted Motor-Columbus Consulting Engineers Inc., Baden, Switzerland, with a study to determine the most suitable project approach option(s) for the implementation of the future nuclear program in the Netherlands. In carrying out this study, Motor-Columbus investigated the following main project approach options: 1. turnkey contract approach; 2. split-package contract approach; 3. multi-contract approach. It is concluded that if applied in the appropriate way, the normal turnkey contract approach represents the most suitable approach under the prevailing situation in the Netherlands. (orig.)

  17. Cell based-gene delivery approaches for the treatment of spinal cord injury and neurodegenerative disorders.

    Science.gov (United States)

    Taha, Masoumeh Fakhr

    2010-03-01

    Cell based-gene delivery has provided an important therapeutic strategy for different disorders in the recent years. This strategy is based on the transplantation of genetically modified cells to express specific genes and to target the delivery of therapeutic factors, especially for the treatment of cancers and neurological, immunological, cardiovascular and heamatopoietic disorders. Although, preliminary reports are encouraging, and experimental studies indicate functionally and structurally improvements in the animal models of different disorders, universal application of this strategy for human diseases requires more evidence. There are a number of parameters that need to be evaluated, including the optimal cell source, the most effective gene/genes to be delivered, the optimal vector and method of gene delivery into the cells and the most efficient route for the delivery of genetically modified cells into the patient. Also, some obstacles have to be overcome, including the safety and usefulness of the approaches and the stability of the improvements. Here, recent studies concerning with the cell-based gene delivery for spinal cord injury and some neurodegenerative disorders such as amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease are briefly reviewed, and their exciting consequences are discussed.

  18. Towards e-Government project assessment: European approach

    Directory of Open Access Journals (Sweden)

    Pavel Mates

    2013-06-01

    Full Text Available The objective of the paper is to analyse current approaches to the assessment of e-Government projects as the specifi c public projects and to suggest how to improve these approaches in order to eliminate their shortcomings. The nonnormative theoretical methods are used to analyse empirical results of previous researches; particularly the deduction method is used to prove that current approaches to the evaluation of e-Government projects have some inequalities, the analogy and comparison methods are used to create general typology of e-Government projects and the induction method is used to seek examples of the indicators and metrics. The results are based on analysis of extensive amount of e-Government projects, which have been realized in different European countries in the past twenty years. The basic result of the research is creation of the ten most common types of e-Government projects typology. The fundamental conclusion obtained from the results of this research is that this typology can be used as the core of new E-Government General Assessment Framework, which eliminates problems of previous approaches, allows adjusting metrics and indicators to each type of projects, keeps comparability of results and thus making possible the use of benchmarking methods.

  19. System supplier approach to projects and operations efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Moe, P O [Siemens Offshore A/S (Norway)

    1994-12-31

    The conference paper outlines the most important elements for a new approach to project realisation that enable a cost reduction of 30-50% compared to conventional methods. The achievements are based on studies and evaluations to the Norwegian Vigdis development project. The system elements covered are the electrical and automation systems including safety and process control and all traditional phases of a project from concept design to the operational phase. The concept involves new principles for project execution where traditional borderlines and interfaces between the various participants have been redefined. Management attention has been verified as an important prerequisite for a successful implementation of this strategy. 2 figs.

  20. Cesarean delivery on maternal request: can the ethical problem be solved by the principlist approach?

    Science.gov (United States)

    Nilstun, Tore; Habiba, Marwan; Lingman, Göran; Saracci, Rodolfo; Da Frè, Monica; Cuttini, Marina

    2008-06-17

    In this article, we use the principlist approach to identify, analyse and attempt to solve the ethical problem raised by a pregnant woman's request for cesarean delivery in absence of medical indications. We use two different types of premises: factual (facts about cesarean delivery and specifically attitudes of obstetricians as derived from the EUROBS European study) and value premises (principles of beneficence and non-maleficence, respect for autonomy and justice).Beneficence/non-maleficence entails physicians' responsibility to minimise harms and maximise benefits. Avoiding its inherent risks makes a prima facie case against cesarean section without medical indication. However, as vaginal delivery can have unintended consequences, there is a need to balance the somewhat dissimilar risks and benefits. The principle of autonomy poses a challenge in case of disagreement between the pregnant woman and the physician. Improved communication aimed to enable better informed choice may overcome some instances of disagreement. The principle of justice prohibits unfair discrimination, and broadly favours optimising resource utilisation. Available evidence supports vaginal birth in uncomplicated term pregnancies as the standard of care. The principlist approach offered a useful framework for ethical analysis of cesarean delivery on maternal request, identified the rights and duties of those involved, and helped reach a conclusion, although conflict at the individual level may remain challenging.

  1. Cesarean delivery on maternal request: Can the ethical problem be solved by the principlist approach?

    Directory of Open Access Journals (Sweden)

    Da Frè Monica

    2008-06-01

    Full Text Available Abstract In this article, we use the principlist approach to identify, analyse and attempt to solve the ethical problem raised by a pregnant woman's request for cesarean delivery in absence of medical indications. We use two different types of premises: factual (facts about cesarean delivery and specifically attitudes of obstetricians as derived from the EUROBS European study and value premises (principles of beneficence and non-maleficence, respect for autonomy and justice. Beneficence/non-maleficence entails physicians' responsibility to minimise harms and maximise benefits. Avoiding its inherent risks makes a prima facie case against cesarean section without medical indication. However, as vaginal delivery can have unintended consequences, there is a need to balance the somewhat dissimilar risks and benefits. The principle of autonomy poses a challenge in case of disagreement between the pregnant woman and the physician. Improved communication aimed to enable better informed choice may overcome some instances of disagreement. The principle of justice prohibits unfair discrimination, and broadly favours optimising resource utilisation. Available evidence supports vaginal birth in uncomplicated term pregnancies as the standard of care. The principlist approach offered a useful framework for ethical analysis of cesarean delivery on maternal request, identified the rights and duties of those involved, and helped reach a conclusion, although conflict at the individual level may remain challenging.

  2. Cesarean delivery on maternal request: Can the ethical problem be solved by the principlist approach?

    Science.gov (United States)

    Nilstun, Tore; Habiba, Marwan; Lingman, Göran; Saracci, Rodolfo; Da Frè, Monica; Cuttini, Marina

    2008-01-01

    In this article, we use the principlist approach to identify, analyse and attempt to solve the ethical problem raised by a pregnant woman's request for cesarean delivery in absence of medical indications. We use two different types of premises: factual (facts about cesarean delivery and specifically attitudes of obstetricians as derived from the EUROBS European study) and value premises (principles of beneficence and non-maleficence, respect for autonomy and justice). Beneficence/non-maleficence entails physicians' responsibility to minimise harms and maximise benefits. Avoiding its inherent risks makes a prima facie case against cesarean section without medical indication. However, as vaginal delivery can have unintended consequences, there is a need to balance the somewhat dissimilar risks and benefits. The principle of autonomy poses a challenge in case of disagreement between the pregnant woman and the physician. Improved communication aimed to enable better informed choice may overcome some instances of disagreement. The principle of justice prohibits unfair discrimination, and broadly favours optimising resource utilisation. Available evidence supports vaginal birth in uncomplicated term pregnancies as the standard of care. The principlist approach offered a useful framework for ethical analysis of cesarean delivery on maternal request, identified the rights and duties of those involved, and helped reach a conclusion, although conflict at the individual level may remain challenging. PMID:18559083

  3. Development of a codrug approach for sustained drug delivery across microneedle-treated skin.

    Science.gov (United States)

    Ghosh, Priyanka; Pinninti, Raghotham R; Hammell, Dana C; Paudel, Kalpana S; Stinchcomb, Audra L

    2013-05-01

    Microneedle (MN) enhanced transdermal drug delivery enables the transport of a host of molecules that cannot be delivered across the skin by passive diffusion alone. However, the skin being a self-regenerating organ heals itself and thus prevents delivery of molecules through micropores for a 7-day time period, the ideal transdermal delivery goal. Hence, it is necessary to employ a second drug molecule, a cyclooxygenase inhibitor to enhance pore lifetime by decreasing local subclinical inflammatory response following MN treatment. A codrug approach using a 3-O-ester codrug of the model drug naltrexone (NTX) with diclofenac (DIC), a cyclooxygenase inhibitor, was tested in vitro as well as in vivo to look at stability, bioconversion and permeation. The results indicated that the approach could be useful for transdermal drug delivery of NTX from a single patch for a week, but stability and solubility optimization will be required for the codrug before it can deliver significant levels of NTX into the plasma. The skin concentration of DIC was high enough to keep the pores open in vivo in a hairless guinea pig model as demonstrated by day seven pore visualization studies. Copyright © 2013 Wiley Periodicals, Inc.

  4. A new approach to cost effective projects: High performance project teams

    International Nuclear Information System (INIS)

    Chambers, N.C.

    1994-01-01

    In low oil price environment in which environmental conditions are more challenging, reservoir characteristics less favourable and political risk increasing, successful projects are required in such cases. The present paper deals with the visionary process of establishing high performance project teams. According to the author, such project teams embody dynamic recognition of holism. Holism is achieved as an output from the process of establishing the drivers and enablers for success on a project. They are given birth during the unfolding of the operators development plans and contracting strategy. The paper discusses the main drivers of project teams comprising purpose and performance goals, selection, common approach, commitment and accountability, and financial alignment

  5. A new approach to cost effective projects: High performance project teams

    Energy Technology Data Exchange (ETDEWEB)

    Chambers, N.C. [Brown and Root Energy Services (United Kingdom)

    1994-12-31

    In low oil price environment in which environmental conditions are more challenging, reservoir characteristics less favourable and political risk increasing, successful projects are required in such cases. The present paper deals with the visionary process of establishing high performance project teams. According to the author, such project teams embody dynamic recognition of holism. Holism is achieved as an output from the process of establishing the drivers and enablers for success on a project. They are given birth during the unfolding of the operators development plans and contracting strategy. The paper discusses the main drivers of project teams comprising purpose and performance goals, selection, common approach, commitment and accountability, and financial alignment

  6. Metabolic approaches to enhance transdermal drug delivery. 1. Effect of lipid synthesis inhibitors.

    Science.gov (United States)

    Tsai, J C; Guy, R H; Thornfeldt, C R; Gao, W N; Feingold, K R; Elias, P M

    1996-06-01

    application of conventional, chemical penetration enhancers, cause a further boost in drug delivery, attributable to the ability of these agents to alter both permeability barrier homeostasis and thermodynamics. This biochemical/metabolic approach provides a novel means to enhance transdermal drug delivery in conjunction with the concurrent or prior use of chemical enhancers.

  7. Experiences of practice facilitators working on the Improved Delivery of Cardiovascular Care project: Retrospective case study.

    Science.gov (United States)

    Liddy, Clare; Rowan, Margo; Valiquette-Tessier, Sophie-Claire; Drosinis, Paul; Crowe, Lois; Hogg, William

    2018-01-01

    To examine the barriers to and facilitators of practice facilitation experienced by participants in the Improving Delivery of Cardiovascular Care (IDOCC) project. Case studies of practice facilitators' narrative reports. Eastern Ontario. Primary care practices that participated in the IDOCC project. Cases were identified by calculating sum scores in order to determine practices' performance relative to their peers. Two case exemplars were selected that scored within ± 1 SD of the total mean score, and a qualitative analysis of practice facilitators' narrative reports was conducted using a 5-factor implementation framework to identify barriers and facilitators. Narratives were divided into 3 phases: planning, implementation, and sustainability. Barriers and facilitators fluctuated over the intervention's 3 phases. Site A reported more barriers (n = 47) than facilitators (n = 38), while site B reported a roughly equal number of barriers (n = 144) and facilitators (n = 136). In both sites, the most common barriers involved organizational and provider factors and the most common facilitators were associated with innovation and structural factors. Both practices encountered various barriers and facilitators throughout the IDOCC's 3 phases. The case studies reveal the complex interactions of these factors over time, and provide insight into the implementation of practice facilitation programs. Copyright© the College of Family Physicians of Canada.

  8. Model Projections of Future Fluvial Sediment Delivery to Major Deltas Under Environmental Change

    Science.gov (United States)

    Darby, S. E.; Dunn, F.; Nicholls, R. J.; Cohen, S.; Zarfl, C.

    2017-12-01

    Deltas are important hot spots for climate change impacts on which over half a billion people live worldwide. Most of the world's deltas are sinking as a result of natural and anthropogenic subsidence and due to eustatic sea level rise. The ability to predict rates of delta aggradation is therefore critical to assessments of the extent to which sedimentation can potentially offset sea level rise, but our ability to make such predictions is severely hindered by a lack of insight into future trends of the fluvial sediment load supplied to their deltas by feeder watersheds. To address this gap we investigate fluvial sediment fluxes under future environmental change for a selection (47) of the world's major river deltas. Specifically, we employed the numerical model WBMsed to project future variations in mean annual fluvial sediment loads under a range of environmental change scenarios that account for changes in climate, socio-economics and dam construction. Our projections indicate a clear decrease (by 34 to 41% on average, depending on the specific scenario) in future fluvial sediment supply to most of the 47 deltas. These reductions in sediment delivery are driven primarily by anthropogenic disturbances, with reservoir construction being the most influential factor globally. Our results indicate the importance of developing new management strategies for reservoir construction and operation.

  9. Accelerated delivery of hydro electrical projects; Livraison acceleree des projets hydroelectriques

    Energy Technology Data Exchange (ETDEWEB)

    Benjannet, Hassine; Bechard, Normand

    2010-09-15

    Hydro electrical projects, as other energy projects, must transform in order to adapt to current market demands. This article describes the solutions developed during the construction of the Eastmain-1-A power plant in order to speed up its delivery and to reduce the costs. These solutions include, more comprehensive land investigations, the simplification of excavation contours, the refit or elimination of certain work spaces, the addition of a second access during construction, the simplification of the formworks, the improvement of work zones access and especially the use of prefabricated elements. [French] Les projets hydroelectriques, comme les autres projets energetiques, doivent subir des transformations pour s'adapter aux exigences actuelles du marche. Cet article presente les solutions mises en oeuvre pour la construction de la Centrale de l'Eastmain-1-A en vue d'en accelerer la livraison et d'en reduire le cout. Ces solutions comprennent, entre autres des investigations de terrain plus approfondies, la simplification des contours d'excavations, le reamenagement ou l'elimination de certains locaux, l'addition d'un deuxieme acces pendant la construction, la simplification des coffrages, l'amelioration des acces aux zones de travail et surtout l'utilisation d'elements prefabriques.

  10. Budgetary Approach to Project Management by Percentage of Completion Method

    Directory of Open Access Journals (Sweden)

    Leszek Borowiec

    2011-07-01

    Full Text Available Efficient and effective project management process is made possible by the use of methods and techniques of project management. The aim of this paper is to present the problems of project management by using Percentage of Completion method. The research material was gathered based on the experience in implementing this method by the Johnson Controls International Company. The article attempts to demonstrate the validity of the thesis that the POC project management method, allows for effective implementation and monitoring of the project and thus is an effective tool in the managing of companies which exploit the budgetary approach. The study presents planning process of basic parameters affecting the effectiveness of the project (such as costs, revenue, margin and characterized how the primary measurements used to evaluate it. The present theme is illustrating by numerous examples for showing the essence of the raised problems and the results are presenting by using descriptive methods, graphical and tabular.

  11. An Analysis of the Design-Build Delivery Approach in Air Force Military Construction

    Science.gov (United States)

    2008-03-01

    Construction (Department of the Air Force, 2000), known as the Blue Book , for a comprehensive description of the Air Force MILCON process and policy...procurement (Mouritsen, 1993; Songer & Molenaar , 1997; Chan et al., 2002) synonymously when describing design-build methods. Delivery and procurement...broad applicability of the new approach (Buckingham, 1989; Mouritsen, 1993; Molenaar & Songer, 1998). The pendulum has now shifted away from the early

  12. Current approaches to enhance CNS delivery of drugs across the brain barriers

    Directory of Open Access Journals (Sweden)

    Lu CT

    2014-05-01

    Full Text Available Cui-Tao Lu,1 Ying-Zheng Zhao,2,3 Ho Lun Wong,4 Jun Cai,5 Lei Peng,2 Xin-Qiao Tian1 1The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, People’s Republic of China; 2Hainan Medical College, Haikou City, Hainan Province, People’s Republic of China; 3College of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang Province, People’s Republic of China; 4School of Pharmacy, Temple University, Philadelphia, PA, USA; 5Departments of Pediatrics and Anatomical Sciences and Neurobiology, University of Louisville School of Medicine Louisville, KY, USA Abstract: Although many agents have therapeutic potentials for central nervous system (CNS diseases, few of these agents have been clinically used because of the brain barriers. As the protective barrier of the CNS, the blood–brain barrier and the blood–cerebrospinal fluid barrier maintain the brain microenvironment, neuronal activity, and proper functioning of the CNS. Different strategies for efficient CNS delivery have been studied. This article reviews the current approaches to open or facilitate penetration across these barriers for enhanced drug delivery to the CNS. These approaches are summarized into three broad categories: noninvasive, invasive, and miscellaneous techniques. The progresses made using these approaches are reviewed, and the associated mechanisms and problems are discussed. Keywords: drug delivery system, blood–brain barrier (BBB, central nervous system, brain-targeted therapy, cerebrospinal fluid (CSF

  13. Engineering approaches to transdermal drug delivery: a tribute to contributions of prof. Robert Langer.

    Science.gov (United States)

    Mitragotri, S

    2013-01-01

    Transdermal drug delivery continues to provide an advantageous route of drug administration over injections. While the number of drugs delivered by passive transdermal patches has increased over the years, no macromolecule is currently delivered by the transdermal route. Substantial research efforts have been dedicated by a large number of researchers representing varied disciplines including biology, chemistry, pharmaceutics and engineering to understand, model and overcome the skin's barrier properties. This article focuses on engineering contributions to the field of transdermal drug delivery. The article pays tribute to Prof. Robert Langer, who pioneered the engineering approach towards transdermal drug delivery. Over a period spanning nearly 25 years since his first publication in the field of transdermal drug delivery, Bob Langer has deeply impacted the field by quantitative analysis and innovative engineering. At the same time, he has inspired several generations of engineers by collaborations and mentorship. His scientific insights, innovative technologies, translational efforts and dedicated mentorship have transformed the field. © 2013 S. Karger AG, Basel.

  14. Reference Scenario Forecasting: A New Approach to Transport Project Assessment

    DEFF Research Database (Denmark)

    Salling, Kim Bang; Leleur, Steen; Skougaard, Britt Zoëga

    2010-01-01

    This paper presents a new approach to transport project assessment in terms of feasibility risk assessment and reference class forecasting. Normally, transport project assessment is based upon a cost-benefit approach where evaluation criteria such as net present values are obtained. Recent research...... construction cost estimates. Hereafter, a quantitative risk analysis is provided making use of Monte Carlo simulation. This stochastic approach facilitates random input parameters based upon reference class forecasting, hence, a parameter data fit has been performed in order to obtain validated probability...... forecasting (RSF) frame. The RSF is anchored in the cost-benefit analysis (CBA), thus, it provides decision-makers with a quantitative mean of assessing the transport infrastructure project. First, the RSF method introduces uncertainties within the CBA by applying Optimism Bias uplifts on the preliminary...

  15. Application of the graded management approach to Battelle's nuclear project

    International Nuclear Information System (INIS)

    Voth, C.B.

    1996-01-01

    Battelle's graded management approach provides an effective and efficient method to perform the Battelle Columbus Laboratories Decommissioning Project (BCLDP). The project is managed by Battelle under their US Nuclear Regulatory Commission (NRC) license but is partially funded by the US Department of Energy (DOE) on a cost-shared basis. Battelle's graded management approach adheres to the regulations and orders governing the BCLDP by the interaction of various plans, procedures, permits, and work instructions. By independent assessment, quality control, and worker training, Battelle has been able to establish a cost-effective approach to performing work and, at the same time, have a controlled checks and balance system to assure the proper safety considerations and project particulars are taken into account

  16. Multiobjective genetic algorithm approaches to project scheduling under risk

    OpenAIRE

    Kılıç, Murat; Kilic, Murat

    2003-01-01

    In this thesis, project scheduling under risk is chosen as the topic of research. Project scheduling under risk is defined as a biobjective decision problem and is formulated as a 0-1 integer mathematical programming model. In this biobjective formulation, one of the objectives is taken as the expected makespan minimization and the other is taken as the expected cost minimization. As the solution approach to this biobjective formulation genetic algorithm (GA) is chosen. After carefully invest...

  17. A Systematic Approach to Modelling Change Processes in Construction Projects

    Directory of Open Access Journals (Sweden)

    Ibrahim Motawa

    2012-11-01

    Full Text Available Modelling change processes within construction projects isessential to implement changes efficiently. Incomplete informationon the project variables at the early stages of projects leads toinadequate knowledge of future states and imprecision arisingfrom ambiguity in project parameters. This lack of knowledge isconsidered among the main source of changes in construction.Change identification and evaluation, in addition to predictingits impacts on project parameters, can help in minimising thedisruptive effects of changes. This paper presents a systematicapproach to modelling change process within construction projectsthat helps improve change identification and evaluation. Theapproach represents the key decisions required to implementchanges. The requirements of an effective change processare presented first. The variables defined for efficient changeassessment and diagnosis are then presented. Assessmentof construction changes requires an analysis for the projectcharacteristics that lead to change and also analysis of therelationship between the change causes and effects. The paperconcludes that, at the early stages of a project, projects with a highlikelihood of change occurrence should have a control mechanismover the project characteristics that have high influence on theproject. It also concludes, for the relationship between changecauses and effects, the multiple causes of change should bemodelled in a way to enable evaluating the change effects moreaccurately. The proposed approach is the framework for tacklingsuch conclusions and can be used for evaluating change casesdepending on the available information at the early stages ofconstruction projects.

  18. hTe exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches

    Institute of Scientific and Technical Information of China (English)

    Vivek Agrahari

    2017-01-01

    Delivering therapeutics to the central nervous system (CNS) and brain-tumor has been a major challenge. hTe current standard treatment approaches for the brain-tumor comprise of surgical resection followed by immunotherapy, radiotherapy, and chemotherapy. However, the current treatments are limited in provid-ing signiifcant beneifts to the patients and despite recent technological advancements; brain-tumor is still challenging to treat. Brain-tumor therapy is limited by the lack of effective and targeted strategies to deliver chemotherapeutic agents across the blood-brain barrier (BBB). hTe BBB is the main obstacle that must be overcome to allow compounds to reach their targets in the brain. Recent advances have boosted the nan-otherapeutic approaches in providing an attractive strategy in improving the drug delivery across the BBB and into the CNS. Compared to conventional formulations, nanoformulations offer signiifcant ad vantages in CNS drug delivery approaches. Considering the above facts, in this review, the physiological/anatomical features of the brain-tumor and the BBB are brielfy discussed. hTe drug transport mechanisms at the BBB are outlined. hTe approaches to deliver chemotherapeutic drugs across the CNS into the brain-tumor using nanocarriers are summarized. In addition, the challenges that need to be addressed in nanotherapeutic ap-proaches for their enhanced clinical application in brain-tumor therapy are discussed.

  19. The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches

    Directory of Open Access Journals (Sweden)

    Vivek Agrahari

    2017-01-01

    Full Text Available Delivering therapeutics to the central nervous system (CNS and brain-tumor has been a major challenge. The current standard treatment approaches for the brain-tumor comprise of surgical resection followed by immunotherapy, radiotherapy, and chemotherapy. However, the current treatments are limited in providing significant benefits to the patients and despite recent technological advancements; brain-tumor is still challenging to treat. Brain-tumor therapy is limited by the lack of effective and targeted strategies to deliver chemotherapeutic agents across the blood-brain barrier (BBB. The BBB is the main obstacle that must be overcome to allow compounds to reach their targets in the brain. Recent advances have boosted the nanotherapeutic approaches in providing an attractive strategy in improving the drug delivery across the BBB and into the CNS. Compared to conventional formulations, nanoformulations offer significant advantages in CNS drug delivery approaches. Considering the above facts, in this review, the physiological/anatomical features of the brain-tumor and the BBB are briefly discussed. The drug transport mechanisms at the BBB are outlined. The approaches to deliver chemotherapeutic drugs across the CNS into the brain-tumor using nanocarriers are summarized. In addition, the challenges that need to be addressed in nanotherapeutic approaches for their enhanced clinical application in brain-tumor therapy are discussed.

  20. Project delivery in HIV/AIDS and TB in Southern Africa: the cross-cultural management imperative.

    Science.gov (United States)

    Claeyé, Frederik; Jackson, Terence

    2011-01-01

    The purpose of this paper is to report the findings of a broad-based study that initially investigated a possible gap in global inputs into the fight against HIV/AIDS and TB co-infection, and outputs in terms of results achieved. It is proposed that such a gap may be hypothesized to be due, at least in part, to inappropriate management regimes within the global health governance structure. The research does not simply question the effectiveness of the management of programs and projects, but rather the inappropriateness resulting from the lack of addressing cross-cultural issues. The factors facilitating or hampering project service delivery were examined, by looking at 12 case studies in Botswana and South Africa. These data were complemented with seven semi-structured interviews with donor organizations and NGOs, conducted in the North. Cultural interactions were investigated by using the concept of "interfaces". The results suggest that there is a disjuncture between the global and local level that affects project delivery. The main issues hampering project outcomes can be summarized as systemic, structural and cultural. The article's main contributions are both theoretical, looking at global project delivery from a cross-cultural management perspective, as well as to development praxis by highlighting the need to focus more critically on cross-cultural management issues within the global health governance structure, and indeed within international development as a whole.

  1. Improving communication between obstetric and neonatology teams for high-risk deliveries: a quality improvement project.

    Science.gov (United States)

    Sundgren, Nathan C; Kelly, Frances C; Weber, Emily M; Moore, Merle L; Gokulakrishnan, Ganga; Hagan, Joseph L; Brand, M Colleen; Gallegos, Jennifer O; Levy, Barbara E; Fortunov, Regine M

    2017-01-01

    Summoning is a key component of communication between obstetrics and neonatal resuscitation team (NRT) in advance of deliveries. A paging system is a commonly used summoning tool. The timeliness and information contained in the page help NRT to optimally prepare for postdelivery infant care. Our aim was to increase the frequency that summoning pages contained gestational age and reason for NRT attendance to >90%. At baseline, 8% of pages contained gestational age and 33% of pages contained a reason for NRT attendance. Sequential Plan-Do-Study-Act cycles were used as our model for quality improvement. During the 8-month improvement period, the per cent of pages increased to 97% for gestational age and 97% for reason for NRT attendance. Measures of page timeliness, our balancing measure, did not change. Summoning communication between obstetric and NRT is crucial for optimal perinatal outcomes. The active involvement of all stakeholders throughout the project resulted in the development of a standardised paging tool and a more informative paging process, which is a key communication tool used in many centres.

  2. Between a rock and a hard place: Management and implementation teams’ expectations of project managers in an agile information systems delivery environment

    Directory of Open Access Journals (Sweden)

    Songezo Nkukwana

    2017-08-01

    Objectives: This case study investigated how project managers could adapt to agile IS implementation environments to remain relevant. Specifically, the views of their key stakeholders (the management and implementation teams were elicited to provide insights into what is expected from agile project managers. Method: A qualitative, inductive content analysis approach using purposive sampling was used to identify 13 participants (comprising management and implementation team members within a large South African insurance company. Semi-structured interviews were conducted with all participants. Results: The management and implementation teams agreed that PM remains highly relevant in an agile environment for ensuring project governance including delivery, risk management, reporting and budgeting. There was, however, disagreement between the management and implementation teams on project management interaction with the implementation team. Management preferred a command and control type project manager, while the implementation team favoured a more inclusive, facilitative PM style. Conclusion: To remain viable in an agile IS project implementation environment within large corporates, project managers need to be aware of what various stakeholders expect of them. They need to retain some of the classic PM functions while adapting to the interpersonal and collaborative requirements of the agile way.

  3. Distributor pricing approaches enabled in Smart Grid to differentiate delivery service quality

    Directory of Open Access Journals (Sweden)

    Zhongwei Jake Zhang

    2014-12-01

    Full Text Available Industry practitioners who advocate retail competition and Demand-side Participation now look for approaches to link both initiatives through distributor pricing. As distributors incrementally convert more traditional assets into Smart Grid assets, they also need to consider different pricing approaches to recover the investment costs and meet the regulatory business requirements. Small electricity consumers need incentives to take part in these initiatives but their delivery service quality should also be closely guarded. Hence this paper addresses the above needs as a whole and investigates a set of distributor pricing approaches with Smart Grid technologies. Pricing of network and non-network based solutions should follow the incremental basis, such as the long run average incremental cost (LRAIC. The benefit of deferring network investment is calculated and should be passed to consumers as peak pricing rebate. A concept of reliability premium (RP based on load point reliability index is proposed, through which customers can express their preference of service quality and adjust their network tariff payment accordingly. A service delivery model is also proposed to utilize the savings from wholesale market trading to compensate for the downgraded service when loads are controlled. The IEEE 123-node distribution test feeder and the IEEE distribution system for RBTS Bus No. 2 are simulated, and solved using General Algebraic Modeling System (GAMS to demonstrate the proposed distributor pricing approaches in Smart Grid.

  4. A projective approach to a language of landscape design

    Directory of Open Access Journals (Sweden)

    Catherine Ward Thompson

    1997-10-01

    Full Text Available Building on the work of Kelly (1955 in personal construct psychology, and Peled (1976, I990 in ecoanalysis, this paper develops projective techniques-which use concepts of personal and phenomenological space-as a means for articulating approaches to landscape design. The projective approach involves two stages. In stage one, projective techniques are used to elicit personal constructs (which may be held at a pre-conscious or sub-conscious level, allowing the holistic experience of landscape to be explored. In stage two, using a 'projection location task' derived from the way we experience and construe the regions of our own bodies, elements of these constructs can then be articulated so as to inform the way we interact and engage with the space around us. This gives insight into the meaning of spatial layouts, which can then be translated into a design language for the structural ordering of space. The author draws on original research conducted with children as well as adults, using projective techniques to draw out their desires and needs in relation to designing their landscape environment. The paper discusses the value of such methods for landscape designers and their clients, and outlines some ongoing research to test the validity of the projection location task.

  5. A Differential Geometric Approach to Nonlinear Filtering: The Projection Filter

    NARCIS (Netherlands)

    Brigo, D.; Hanzon, B.; LeGland, F.

    1998-01-01

    This paper presents a new and systematic method of approximating exact nonlinear filters with finite dimensional filters, using the differential geometric approach to statistics. The projection filter is defined rigorously in the case of exponential families. A convenient exponential family is

  6. Implementing Project Based Learning Approach to Graphic Design Course

    Science.gov (United States)

    Riyanti, Menul Teguh; Erwin, Tuti Nuriah; Suriani, S. H.

    2017-01-01

    The purpose of this study was to develop a learning model based Commercial Graphic Design Drafting project-based learning approach, was chosen as a strategy in the learning product development research. University students as the target audience of this model are the students of the fifth semester Visual Communications Design Studies Program…

  7. Diversity Management Change Projects: In Need of Alternative Conceptual Approaches?

    Directory of Open Access Journals (Sweden)

    Christina Evans

    2012-09-01

    Full Text Available Drawing on a meta-analysis of an evaluation of a European Social Fund project aimed at enhancing employment opportunities for women in Information Technology, Electronic and Computing (ITEC, this paper critically debates how effectual a diversity management approach alone is as an underpinning rationale for change in the complex area of diversity. The paper draws on the experiences of ‘partner organizations’, gathered through interviews conducted during the evaluation stage of the project. The paper discusses some of the tensions experienced by partner organizations, thus providing new insights into why such projects are not as effectual as they might be. The paper concludes by presenting a case for the need to re-conceptualise how change as part of a wider diversity management approach might best be conceptualized. We suggest that a ‘systems approach’ could prove a more fruitful way of conceptualizing change of this nature given the inter-dependences between different organizations and institutions.

  8. Optimization and design of ibuprofen-loaded nanostructured lipid carriers using a hybrid-design approach for ocular drug delivery

    Science.gov (United States)

    Rathod, Vishal

    The objective of the present project was to develop the Ibuprofen-loaded Nanostructured Lipid Carrier (IBU-NLCs) for topical ocular delivery based on substantial pre-formulation screening of the components and understanding the interplay between the formulation and process variables. The BCS Class II drug: Ibuprofen was selected as the model drug for the current study. IBU-NLCs were prepared by melt emulsification and ultrasonication technique. Extensive pre-formulation studies were performed to screen the lipid components (solid and liquid) based on drug's solubility and affinity as well as components compatibility. The results from DSC & XRD assisted in selecting the most suitable ratio to be utilized for future studies. DynasanRTM 114 was selected as the solid lipid & MiglyolRTM 840 was selected as the liquid lipid based on preliminary lipid screening. The ratio of 6:4 was predicted to be the best based on its crystallinity index and the thermal events. As there are many variables involved for further optimization of the formulation, a single design approach is not always adequate. A hybrid-design approach was applied by employing the Plackett Burman design (PBD) for preliminary screening of 7 critical variables, followed by Box-Behnken design (BBD), a sub-type of response surface methodology (RSM) design using 2 relatively significant variables from the former design and incorporating Surfactant/Co-surfactant ratio as the third variable. Comparatively, KolliphorRTM HS15 demonstrated lower Mean Particle Size (PS) & Polydispersity Index (PDI) and KolliphorRTM P188 resulted in Zeta Potential (ZP) ibuprofen thereafter over several hours. These values also confirm that the production method, and all other selected variables, effectively promoted the incorporation of ibuprofen in NLC. Quality by Design (QbD) approach was successfully implemented in developing a robust ophthalmic formulation with superior physicochemical and morphometric properties. NLCs as the

  9. Incremental projection approach of regularization for inverse problems

    Energy Technology Data Exchange (ETDEWEB)

    Souopgui, Innocent, E-mail: innocent.souopgui@usm.edu [The University of Southern Mississippi, Department of Marine Science (United States); Ngodock, Hans E., E-mail: hans.ngodock@nrlssc.navy.mil [Naval Research Laboratory (United States); Vidard, Arthur, E-mail: arthur.vidard@imag.fr; Le Dimet, François-Xavier, E-mail: ledimet@imag.fr [Laboratoire Jean Kuntzmann (France)

    2016-10-15

    This paper presents an alternative approach to the regularized least squares solution of ill-posed inverse problems. Instead of solving a minimization problem with an objective function composed of a data term and a regularization term, the regularization information is used to define a projection onto a convex subspace of regularized candidate solutions. The objective function is modified to include the projection of each iterate in the place of the regularization. Numerical experiments based on the problem of motion estimation for geophysical fluid images, show the improvement of the proposed method compared with regularization methods. For the presented test case, the incremental projection method uses 7 times less computation time than the regularization method, to reach the same error target. Moreover, at convergence, the incremental projection is two order of magnitude more accurate than the regularization method.

  10. A Bayesian approach to real-time 3D tumor localization via monoscopic x-ray imaging during treatment delivery

    International Nuclear Information System (INIS)

    Li, Ruijiang; Fahimian, Benjamin P.; Xing, Lei

    2011-01-01

    Purpose: Monoscopic x-ray imaging with on-board kV devices is an attractive approach for real-time image guidance in modern radiation therapy such as VMAT or IMRT, but it falls short in providing reliable information along the direction of imaging x-ray. By effectively taking consideration of projection data at prior times and/or angles through a Bayesian formalism, the authors develop an algorithm for real-time and full 3D tumor localization with a single x-ray imager during treatment delivery. Methods: First, a prior probability density function is constructed using the 2D tumor locations on the projection images acquired during patient setup. Whenever an x-ray image is acquired during the treatment delivery, the corresponding 2D tumor location on the imager is used to update the likelihood function. The unresolved third dimension is obtained by maximizing the posterior probability distribution. The algorithm can also be used in a retrospective fashion when all the projection images during the treatment delivery are used for 3D localization purposes. The algorithm does not involve complex optimization of any model parameter and therefore can be used in a ''plug-and-play'' fashion. The authors validated the algorithm using (1) simulated 3D linear and elliptic motion and (2) 3D tumor motion trajectories of a lung and a pancreas patient reproduced by a physical phantom. Continuous kV images were acquired over a full gantry rotation with the Varian TrueBeam on-board imaging system. Three scenarios were considered: fluoroscopic setup, cone beam CT setup, and retrospective analysis. Results: For the simulation study, the RMS 3D localization error is 1.2 and 2.4 mm for the linear and elliptic motions, respectively. For the phantom experiments, the 3D localization error is < 1 mm on average and < 1.5 mm at 95th percentile in the lung and pancreas cases for all three scenarios. The difference in 3D localization error for different scenarios is small and is not

  11. Novel approaches to vaginal delivery and safety of microbicides: biopharmaceuticals, nanoparticles, and vaccines.

    Science.gov (United States)

    Whaley, Kevin J; Hanes, Justin; Shattock, Robin; Cone, Richard A; Friend, David R

    2010-12-01

    The HIV-1 epidemic remains unchecked despite existing technology; vaccines and microbicides in development may help reverse the epidemic. Reverse transcriptase inhibitors (RTIs) formulated in gels tenofovir (TFV) and IVRs (dapivirine) are under clinical development. While TFV or similar products may prove successful for HIV-1, alternatives to RTIs may provide additional benefits, e.g., broader STI prevention. Biopharmaceutical agents under development as microbicides include cyanovirin, RANTES analogues, commensals, and Mabs. Cost of manufacturing biopharmaceuticals has been reduced and they can be formulated into tablets, films, and IVRs for vaginal delivery. Nanotechnology offers a novel approach to formulate microbicides potentially leading to uniform epithelial delivery. Delivery through vaginal mucus may be possible by controlling nanoparticle size and surface characteristics. Combining prevention modalities may be the most effective means of preventing STI transmission, importantly, codelivery of microbicides and vaccines has demonstrated. Finally, the safety of microbicide preparations and excipients commonly used can be assessed using a mouse/HSV-2 susceptibility model. Screening of new microbicide candidates and formulation excipients may avoid past issues of enhancing HIV-1 transmission. This article forms part of a special supplement covering several presentations on novel microbicide formulations from the symposium on "Recent Trends in Microbicide Formulations" held on 25 and 26 January 2010, Arlington, VA. Copyright © 2010 Elsevier B.V. All rights reserved.

  12. Worksheet of Exogenous Variables that Impact the Success of Validation Stage of Product Delivery of a Project

    Directory of Open Access Journals (Sweden)

    Altino José Mentzingen de Moraes

    2015-02-01

    Full Text Available In the theory presented by PMBoK© - Project Management Book of Knowledge the Project Management [1] features - among others - the Disciplines of Scope and Quality. The Discipline of Scope, to become effective, must provide the execution of a hypothetical step (not defined in its text but perceived by the present author of this paper that can be termed as Planning Stage of Project Result. The Discipline of Quality, to become effective, must provide the execution of an also hypothetical step (also not defined in its text but also perceived by the same present author of this paper that can be termed as Validation Stage of Product Delivery.In the theory presented by PMBoK© - Project Management Book of Knowledge the Project Management [1] features - among others - the Disciplines of Scope and Quality. The Discipline of Scope, to become effective, must provide the execution of a hypothetical step (not defined in its text but perceived by the present author of this paper that can be termed as Planning Stage of Project Result. The Discipline of Quality, to become effective, must provide the execution of an also hypothetical step (also not defined in its text but also perceived by the same present author of this paper that can be termed as Validation Stage of Product Delivery.In the theory presented by PMBoK© - Project Management Book of Knowledge the Project Management [1] features - among others - the Disciplines of Scope and Quality. The Discipline of Scope, to become effective, must provide the execution of a hypothetical step (not defined in its text but perceived by the present author of this paper that can be termed as Planning Stage of Project Result. The Discipline of Quality, to become effective, must provide the execution of an also hypothetical step (also not defined in its text but also perceived by the same present author of this paper that can be termed as Validation Stage of Product Delivery. The importance of both Stages is crucial to

  13. One System Integrated Project Team: Retrieval And Delivery Of The Hanford Tank Wastes For Vitrification In The Waste Treatment Plant

    International Nuclear Information System (INIS)

    Harp, Benton J.; Kacich, Richard M.; Skwarek, Raymond J.

    2012-01-01

    wastes and for building and operating the WTP. The tank wastes are the result of Hanford's nearly fifty (50) years of plutonium production. In the intervening years, waste characteristics have been increasingly better understood. However, waste characteristics that are uncertain and will remain as such represent a significant technical challenge in terms of retrieval, transport, and treatment, as well as for design and construction ofWTP. What also is clear is that the longer the waste remains in the tanks, the greater the risk to the environment and the people of the Pacific Northwest. The goal of both projects - tank operations and waste treatment - is to diminish the risks posed by the waste in the tanks at the earliest possible date. About two hundred (200) WTP and TOC employees comprise the IPT. Individual work groups within One System include Technical, Project Integration snd Controls, Front-End Design and Project Definition, Commissioning, Nuclear Safety and Engineering Systems Integration, and Environmental Safety and Health and Quality Assurance (ESHandQA). Additional functions and team members will be added as the WTP approaches the operational phase. The team has undertaken several initiatives since its formation to collaborate on issues: (1) alternate scenarios for delivery of wastes from the tank farms to WTP; (2) improvements in managing Interface Control Documents; (3) coordination on various technical issues, including the Defense Nuclear Facilities Nuclear Safety Board's Recommendation 2010-2; (4) deployment of the SmartPlant Foundation-configuration Management System; and (5) preparation of the joint contract deliverable of the Operational Readiness Support Plan

  14. One System Integrated Project Team: Retrieval And Delivery Of The Hanford Tank Wastes For Vitrification In The Waste Treatment Plant

    Energy Technology Data Exchange (ETDEWEB)

    Harp, Benton J. [Department of Energy, Office of River Protection, Richland, Washington (United States); Kacich, Richard M. [Bechtel National, Inc., Richland, WA (United States); Skwarek, Raymond J. [Washington River Protection Solutions LLC, Richland, WA (United States)

    2012-12-20

    wastes and for building and operating the WTP. The tank wastes are the result of Hanford's nearly fifty (50) years of plutonium production. In the intervening years, waste characteristics have been increasingly better understood. However, waste characteristics that are uncertain and will remain as such represent a significant technical challenge in terms of retrieval, transport, and treatment, as well as for design and construction ofWTP. What also is clear is that the longer the waste remains in the tanks, the greater the risk to the environment and the people of the Pacific Northwest. The goal of both projects - tank operations and waste treatment - is to diminish the risks posed by the waste in the tanks at the earliest possible date. About two hundred (200) WTP and TOC employees comprise the IPT. Individual work groups within One System include Technical, Project Integration & Controls, Front-End Design & Project Definition, Commissioning, Nuclear Safety & Engineering Systems Integration, and Environmental Safety and Health and Quality Assurance (ESH&QA). Additional functions and team members will be added as the WTP approaches the operational phase. The team has undertaken several initiatives since its formation to collaborate on issues: (1) alternate scenarios for delivery of wastes from the tank farms to WTP; (2) improvements in managing Interface Control Documents; (3) coordination on various technical issues, including the Defense Nuclear Facilities Nuclear Safety Board's Recommendation 2010-2; (4) deployment of the SmartPlant Foundation-configuration Management System; and (5) preparation of the joint contract deliverable of the Operational Readiness Support Plan.

  15. One System Integrated Project Team: Retrieval and Delivery of Hanford Tank Wastes for Vitrification in the Waste Treatment Plant - 13234

    International Nuclear Information System (INIS)

    Harp, Benton J.; Kacich, Richard M.; Skwarek, Raymond J.

    2013-01-01

    wastes and for building and operating the WTP. The tank wastes are the result of Hanford's nearly fifty (50) years of plutonium production. In the intervening years, waste characteristics have been increasingly better understood. However, waste characteristics that are uncertain and will remain as such represent a significant technical challenge in terms of retrieval, transport, and treatment, as well as for design and construction of WTP. What also is clear is that the longer the waste remains in the tanks, the greater the risk to the environment and the people of the Pacific Northwest. The goal of both projects - tank operations and waste treatment - is to diminish the risks posed by the waste in the tanks at the earliest possible date. About two hundred (200) WTP and TOC employees comprise the IPT. Individual work groups within One System include Technical, Project Integration and Controls, Front-End Design and Project Definition, Commissioning, Nuclear Safety and Engineering Systems Integration, and Environmental Safety and Health and Quality Assurance (ESH and QA). Additional functions and team members will be added as the WTP approaches the operational phase. The team has undertaken several initiatives since its formation to collaborate on issues: (1) alternate scenarios for delivery of wastes from the tank farms to WTP; (2) improvements in managing Interface Control Documents; (3) coordination on various technical issues, including the Defense Nuclear Facilities Nuclear Safety Board's Recommendation 2010-2; (4) deployment of the SmartPlant R Foundation-Configuration Management System; and (5) preparation of the joint contract deliverable of the Operational Readiness Support Plan. (authors)

  16. One System Integrated Project Team: Retrieval and Delivery of Hanford Tank Wastes for Vitrification in the Waste Treatment Plant - 13234

    Energy Technology Data Exchange (ETDEWEB)

    Harp, Benton J. [U.S. Department of Energy, Office of River Protection, Post Office Box 550, Richland, Washington 99352 (United States); Kacich, Richard M. [Bechtel National, Inc., 2435 Stevens Center Place, Richland, Washington 99354 (United States); Skwarek, Raymond J. [Washington River Protection Solutions LLC, Post Office Box 850, Richland, Washington 99352 (United States)

    2013-07-01

    for retrieving the tank wastes and for building and operating the WTP. The tank wastes are the result of Hanford's nearly fifty (50) years of plutonium production. In the intervening years, waste characteristics have been increasingly better understood. However, waste characteristics that are uncertain and will remain as such represent a significant technical challenge in terms of retrieval, transport, and treatment, as well as for design and construction of WTP. What also is clear is that the longer the waste remains in the tanks, the greater the risk to the environment and the people of the Pacific Northwest. The goal of both projects - tank operations and waste treatment - is to diminish the risks posed by the waste in the tanks at the earliest possible date. About two hundred (200) WTP and TOC employees comprise the IPT. Individual work groups within One System include Technical, Project Integration and Controls, Front-End Design and Project Definition, Commissioning, Nuclear Safety and Engineering Systems Integration, and Environmental Safety and Health and Quality Assurance (ESH and QA). Additional functions and team members will be added as the WTP approaches the operational phase. The team has undertaken several initiatives since its formation to collaborate on issues: (1) alternate scenarios for delivery of wastes from the tank farms to WTP; (2) improvements in managing Interface Control Documents; (3) coordination on various technical issues, including the Defense Nuclear Facilities Nuclear Safety Board's Recommendation 2010-2; (4) deployment of the SmartPlant{sup R} Foundation-Configuration Management System; and (5) preparation of the joint contract deliverable of the Operational Readiness Support Plan. (authors)

  17. Problems and Projects Based Approach For Analog Electronic Circuits' Course

    Directory of Open Access Journals (Sweden)

    Vahé Nerguizian

    2009-04-01

    Full Text Available New educational methods and approaches are recently introduced and implemented at several North American and European universities using Problems and Projects Based Approach (PPBA. The PPBA employs a teaching technique based mostly on competences/skills rather than only on knowledge. This method has been implemented and proven by several pedagogical instructors and authors at several educational institutions. This approach is used at different disciplines such as medicine, biology, engineering and many others. It has the advantage to improve the student's skills and the knowledge retention rate, and reflects the 21st century industrial/company needs and demands. Before implementing this approach to a course, a good resources preparation and planning is needed upfront by the responsible or instructor of the course to achieve the course and students related objectives. This paper presents the preparation, the generated documentation and the implementation of a pilot project utilizing PPBA education for a second year undergraduate electronic course over a complete semester, and for two different class groups (morning and evening groups. The outcome of this project (achieved goals, observed difficulties and lessons learned is presented based on different tools such as students 'in class' communication and feedback, different course evaluation forms and the professor/instructor feedback. Resources, challenges, difficulties and recommendations are also assessed and presented. The impact, the effect and the results (during and at the end of the academic fall session of the PPBA on students and instructor are discussed, validated, managed and communicated to help other instructor in taking appropriate approach decisions with respect to this new educational approach compared to the classical one.

  18. National conversion pilot project: A creative approach to recyling

    International Nuclear Information System (INIS)

    Gandee, K.R.; Taylor, R.A.; Cornils, K.N.

    1995-01-01

    As a result of the Bush-Yeltsin summit in 1991, the U.S. Department of Energy (DOE) has undergone a significant downsizing of its defense mission. In July 1992, the Rocky Flats site in Colorado was the first DOE site to be closed. Its mission was changed from defense to environmental cleanup and economic development. Recognizing the need to assist displaced workers and affected communities and to conduct cost-effective cleanup of DOE sites, Congress initiated two legislative provisions in the 1994 National Defense Authorization Act that required DOE to (a) provide local impact assistance to communities that are affected by the defense downsizing and (b) conduct at least One waste recycling project within the 1994 fiscal year. At the Rocky Flats site, the National Conversion Pilot Project represents an innovative approach in which both Congressional requirements are achieved simultaneously, and the strategy for meeting these requirements was developed through the active participation of all stakeholders of the project

  19. Challenges in the delivery of nutrition services to hospital discharged older adults: the community connections demonstration project.

    Science.gov (United States)

    Sahyoun, Nadine R; Akobundu, Ucheoma; Coray, Kevin; Netterville, Linda

    2009-04-01

    The objective of this project was to explore the effort necessary to transform the Older Americans Act Nutrition Program (OAANP) into core programs within an integrated health care delivery system that serves hospital-discharged older adults in order to assist them in reintegrating into the community. Six OAANPs in six states were funded and provided technical assistance to develop coalitions with hospitals and community organizations. Each demonstration site was unique and faced many challenges in reaching out to a hospitalized vulnerable population. This project also provided opportunities to try out new initiatives and examine their sustainability within the community.

  20. EFFICACY OF SUBMUCOSAL DELIVERY THROUGH A PARAPHARYNGEAL APPROACH IN THE TREATMENT OF LIMITED CRICOID CHONDROMA

    Directory of Open Access Journals (Sweden)

    M.T. Khorsi Y. Amidi

    2008-05-01

    Full Text Available Cartilaginous tumors comprise 1% of all laryngeal masses. Since they grow slowly and metastasis is rare, long term survival is expected in cases of chondroma and chondrosarcoma. Thus, based on these facts and the fact that total salvage surgery after recurrence of previous tumor does not influence treatment outcomes, "Quality of Life" must be taken into great consideration. Based on 3 cases of limited condrosarcoma that we have successfully operated on using submucosal delivery through a parapharyngeal approach, after several years of recurrence free follow ups, authors determine this technique as an efficient method of approach to these tumors. Since this technique takes less time and there is no need for glottic incision and the patient is discharged in 2 days without insertion of endolaryngeal stent, we believe this method is superior to laryngofissure or total laryngectomy.

  1. Six Sigma Project Selection Using Fuzzy TOPSIS Decision Making Approach

    Directory of Open Access Journals (Sweden)

    Rajeev Rathi

    2015-05-01

    Full Text Available Six Sigma is considered as a logical business strategy that attempts to identify and eliminate the defects or failures for improving the quality of product and processes. A decision on project selection in Six Sigma is always very critical; it plays a key role in successful implementation of Six Sigma. Selection of a right Six Sigma project is essentially important for an automotive company because it greatly influences the manufacturing costs. This paper discusses an approach for right Six Sigma project selection at an automotive industry using fuzzy logic based TOPSIS method. The fuzzy TOPSIS is a well recognized tool to undertake the fuzziness of the data involved in choosing the right preferences. In this context, evaluation criteria have been designed for selection of best alternative. The weights of evaluation criteria are calculated by using the MDL (modified digital logic method and final ranking is calculated through priority index obtained by using fuzzy TOPSIS method. In the selected case study, this approach has rightly helped to identify the right project for implementing Six Sigma for achieving improvement in productivity.

  2. The effect of colour and design in labour and delivery: A scientific approach

    Science.gov (United States)

    Duncan, Jane

    2011-03-01

    This study was part of a broader three year research project at London's Chelsea and Westminster Hospital, "A Study of the Effect of the Visual and Performing Arts in Healthcare", exploring whether visual and performing arts have any measurable effect on physiological, psychological and biological outcomes of clinical significance on patient recovery, and providing a potential cost saving benefit to the NHS. In this specific study of women in labour, two measurements were identified as having clinical significance for achieving optimal outcomes during labour and delivery: length of labour and frequency of requirement for analgesia. A screen was designed to hide emergency equipment with the joint aim of reducing women's anxieties and (through visual art) acting as a focal point of attention and distraction during labour, thus diminishing requirements for analgesia. Results demonstrated, in the presence of the screen, a statistically significant shortening of the duration of labour by 2.1h with frequency of requests for epidural analgesia 7% lower in the study group than in the control group. The significant clinical outcomes of this research provide the evidence of the value of integrating visual art into the environment of a labour and delivery room, improving the quality of the maternity service and potentially delivering real cost savings benefits to Hospitals.

  3. The energy sector in Northeast Asia : new projects, delivery systems and prospects for co-operation

    International Nuclear Information System (INIS)

    Ivanov, V.I.

    2000-01-01

    This study examines the needs and opportunities for energy co-operation in Northeast Asia, with particular reference to development of resources in eastern Russia, Siberia and the Far East to supply energy to consumers in Northeast Asia. Given the high projected demand for energy resources, Japan, South Korea and China are compelled to consider diversifying their energy supplies and developing new links with eastern Russia. The environmental degradation caused by coal burning in China is another incentive for looking for sources of natural gas in Eurasia. Russia and Japan are concentrating on the Sakhalin oil and gas projects. China and Russia have agreed to work closely in the energy sector, focusing on a pipeline from the natural gas field near Irkutsk. The challenges lies in developing a co-ordinated approach to energy resource development and use, by modifying energy policies and long-term supply outlooks. Another challenge lies in the fact that private investors and intergovernmental co-operation are required to build an expensive cross-border infrastructure to transport natural gas, electricity and oil. Co-operation is also required to improve energy efficiency, modernize existing facilities and promote cleaner sources of energy, energy conservation and environmental protection. This report examined forecasted energy demand and imports in Northeast Asia and identified opportunities for co-operation. refs., tabs

  4. A global health delivery framework approach to epilepsy care in resource-limited settings.

    Science.gov (United States)

    Cochran, Maggie F; Berkowitz, Aaron L

    2015-11-15

    The Global Health Delivery (GHD) framework (Farmer, Kim, and Porter, Lancet 2013;382:1060-69) allows for the analysis of health care delivery systems along four axes: a care delivery value chain that incorporates prevention, diagnosis, and treatment of a medical condition; shared delivery infrastructure that integrates care within existing healthcare delivery systems; alignment of care delivery with local context; and generation of economic growth and social development through the health care delivery system. Here, we apply the GHD framework to epilepsy care in rural regions of low- and middle-income countries (LMIC) where there are few or no neurologists. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Relation of project managers' personality and project performance: An approach based on value stream mapping

    Directory of Open Access Journals (Sweden)

    Maurizio Bevilacqua

    2014-09-01

    Full Text Available Purpose: This work investigates the influence of project managers’ personality on the success of a project in a Multinational Corporation. The methodology proposed for analyzing the project managers’ personality is based on the Myers-Briggs Type Indicator.Design/methodology/approach: Forty projects carried out in 2012 by multinational corporation, concerning new product development (NPD, have been analyzed, comparing the profile of project managers with results obtained in terms of traditional performance indexes (time delay and over-budget of projects and performance indexes usually used in “Lean Production” sector (waste time and type of “wastes”. A detailed analysis of the most important “wastes” during the project development is carried out using the Value Stream Mapping (VSM technique.Findings and Originality/value: Relying on the Myers–Briggs personality instrument, results show that extroverted managers (as opposed to introverted managers carry out projects that show lower delay and lower waste time. Introverted managers often make “Over-processing” and “Defect” types of waste. Moreover, lower delay and over-budget have been shown by perceiving managers.Research limitations: Regarding the limitations of this work it is necessary to highlight that we collected data from project managers in a retrospective way. While we believe that several aspects of our data collection effort helped enhance the accuracy of the results, future research could conduct real-time case study research to get more detailed insights into the proposed relationships and avoid retrospective bias. Moreover we focused on a single respondent, the project manager. This helped us ensure that their interpretations played an important role in product development. But, we cannot examined the opinion of team members that could be different from project managers opinion regarding some questions.Originality/value: This research provides insight useful

  6. A data-driven predictive approach for drug delivery using machine learning techniques.

    Directory of Open Access Journals (Sweden)

    Yuanyuan Li

    Full Text Available In drug delivery, there is often a trade-off between effective killing of the pathogen, and harmful side effects associated with the treatment. Due to the difficulty in testing every dosing scenario experimentally, a computational approach will be helpful to assist with the prediction of effective drug delivery methods. In this paper, we have developed a data-driven predictive system, using machine learning techniques, to determine, in silico, the effectiveness of drug dosing. The system framework is scalable, autonomous, robust, and has the ability to predict the effectiveness of the current drug treatment and the subsequent drug-pathogen dynamics. The system consists of a dynamic model incorporating both the drug concentration and pathogen population into distinct states. These states are then analyzed using a temporal model to describe the drug-cell interactions over time. The dynamic drug-cell interactions are learned in an adaptive fashion and used to make sequential predictions on the effectiveness of the dosing strategy. Incorporated into the system is the ability to adjust the sensitivity and specificity of the learned models based on a threshold level determined by the operator for the specific application. As a proof-of-concept, the system was validated experimentally using the pathogen Giardia lamblia and the drug metronidazole in vitro.

  7. Human gene therapy: novel approaches to improve the current gene delivery systems.

    Science.gov (United States)

    Cucchiarini, Magali

    2016-06-01

    Even though gene therapy made its way through the clinics to treat a number of human pathologies since the early years of experimental research and despite the recent approval of the first gene-based product (Glybera) in Europe, the safe and effective use of gene transfer vectors remains a challenge in human gene therapy due to the existence of barriers in the host organism. While work is under active investigation to improve the gene transfer systems themselves, the use of controlled release approaches may offer alternative, convenient tools of vector delivery to achieve a performant gene transfer in vivo while overcoming the various physiological barriers that preclude its wide use in patients. This article provides an overview of the most significant contributions showing how the principles of controlled release strategies may be adapted for human gene therapy.

  8. A novel approach to transformed biometrics using successive projections

    Science.gov (United States)

    Gopi, E. S.

    2010-02-01

    Unlike user created password, number of biometrics is limited for creating account in different organizations. Transformed biometrics attempts to solve the problem by transforming the biometric into another form, which is unique to the particular organization. This makes the availability of different transformed biometrics in different organizations transformed from the same biometrics and helps in foolproof transactions. In this article a novel approach to transformed biometrics using successive projection technique is suggested .In the proposed technique, the user can register up to 5*4n-1 organizations if the length of the biometric password is 'n'.

  9. Off-peak delivery : a pilot project for the Chicago region : final report.

    Science.gov (United States)

    2015-08-25

    Off-peak delivery (OPD) is a simple concept, but it can be challenging to implement because the benefits and costs are not always evenly distributed. Carries generally like the idea because it can save them time and money, but receiving businesses of...

  10. Modeling of problems of projection: A non-countercyclic approach

    Directory of Open Access Journals (Sweden)

    Jason Ginsburg

    2016-06-01

    Full Text Available This paper describes a computational implementation of the recent Problems of Projection (POP approach to the study of language (Chomsky 2013; 2015. While adopting the basic proposals of POP, notably with respect to how labeling occurs, we a attempt to formalize the basic proposals of POP, and b develop new proposals that overcome some problems with POP that arise with respect to cyclicity, labeling, and wh-movement operations. We show how this approach accounts for simple declarative sentences, ECM constructions, and constructions that involve long-distance movement of a wh-phrase (including the that-trace effect. We implemented these proposals with a computer model that automatically constructs step-by-step derivations of target sentences, thus making it possible to verify that these proposals work.

  11. Improving family planning services delivery and uptake: experiences from the "Reversing the Stall in Fertility Decline in Western Kenya Project".

    Science.gov (United States)

    Amo-Adjei, Joshua; Mutua, Michael; Athero, Sherine; Izugbara, Chimaraoke; Ezeh, Alex

    2017-10-10

    In this paper, we reflect on our experiences of implementing a multipronged intervention to improve sexual and reproductive health outcomes. The project used family planning as its entry point and was implemented in two high fertility counties-Busia and Siaya in Kenya. The intervention, implemented by a seven-member consortium, involved: family planning services delivery; regular training of service providers to deliver high quality services; monitoring and evaluation; strengthening of commodity chain delivery and forecasting; school-based and out-of-school based sexuality education; and advocacy and stakeholder engagements at the community, county and national levels. Over a 5-year period, the project contributed to raising demand for family planning considerably, evidenced in fertility decline. It also improved the capacity of family planning services providers, increased commitment and awareness of county government and other community stakeholders on the importance of investments in family planning. Our collaborations with organisations interested in sexual and reproductive health issues substantially enhanced the consortium's ability to increase demand for, and supply of family planning commodities. These collaborations are proving useful in the continuity and sustainability of project achievements.

  12. Evaluation of Embedded System Component Utilized in Delivery Integrated Design Project Course

    Science.gov (United States)

    Junid, Syed Abdul Mutalib Al; Hussaini, Yusnira; Nazmie Osman, Fairul; Razak, Abdul Hadi Abdul; Idros, Mohd Faizul Md; Karimi Halim, Abdul

    2018-03-01

    This paper reports the evaluation of the embedded system component utilized in delivering the integrated electronic engineering design project course. The evaluation is conducted based on the report project submitted as to fulfil the assessment criteria for the integrated electronic engineering design project course named; engineering system design. Six projects were assessed in this evaluation. The evaluation covers the type of controller, programming language and the number of embedded component utilization as well. From the evaluation, the C-programming based language is the best solution preferred by the students which provide them flexibility in the programming. Moreover, the Analog to Digital converter is intensively used in the projects which include sensors in their proposed design. As a conclusion, in delivering the integrated design project course, the knowledge over the embedded system solution is very important since the high density of the knowledge acquired in accomplishing the project assigned.

  13. Integrated variable projection approach (IVAPA) for parallel magnetic resonance imaging.

    Science.gov (United States)

    Zhang, Qiao; Sheng, Jinhua

    2012-10-01

    Parallel magnetic resonance imaging (pMRI) is a fast method which requires algorithms for the reconstructing image from a small number of measured k-space lines. The accurate estimation of the coil sensitivity functions is still a challenging problem in parallel imaging. The joint estimation of the coil sensitivity functions and the desired image has recently been proposed to improve the situation by iteratively optimizing both the coil sensitivity functions and the image reconstruction. It regards both the coil sensitivities and the desired images as unknowns to be solved for jointly. In this paper, we propose an integrated variable projection approach (IVAPA) for pMRI, which integrates two individual processing steps (coil sensitivity estimation and image reconstruction) into a single processing step to improve the accuracy of the coil sensitivity estimation using the variable projection approach. The method is demonstrated to be able to give an optimal solution with considerably reduced artifacts for high reduction factors and a low number of auto-calibration signal (ACS) lines, and our implementation has a fast convergence rate. The performance of the proposed method is evaluated using a set of in vivo experiment data. Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. A new approach for modelling variability in residential construction projects

    Directory of Open Access Journals (Sweden)

    Mehrdad Arashpour

    2013-06-01

    Full Text Available The construction industry is plagued by long cycle times caused by variability in the supply chain. Variations or undesirable situations are the result of factors such as non-standard practices, work site accidents, inclement weather conditions and faults in design. This paper uses a new approach for modelling variability in construction by linking relative variability indicators to processes. Mass homebuilding sector was chosen as the scope of the analysis because data is readily available. Numerous simulation experiments were designed by varying size of capacity buffers in front of trade contractors, availability of trade contractors, and level of variability in homebuilding processes. The measurements were shown to lead to an accurate determination of relationships between these factors and production parameters. The variability indicator was found to dramatically affect the tangible performance measures such as home completion rates. This study provides for future analysis of the production homebuilding sector, which may lead to improvements in performance and a faster product delivery to homebuyers.

  15. A new approach for modelling variability in residential construction projects

    Directory of Open Access Journals (Sweden)

    Mehrdad Arashpour

    2013-06-01

    Full Text Available The construction industry is plagued by long cycle times caused by variability in the supply chain. Variations or undesirable situations are the result of factors such as non-standard practices, work site accidents, inclement weather conditions and faults in design. This paper uses a new approach for modelling variability in construction by linking relative variability indicators to processes. Mass homebuilding sector was chosen as the scope of the analysis because data is readily available. Numerous simulation experiments were designed by varying size of capacity buffers in front of trade contractors, availability of trade contractors, and level of variability in homebuilding processes. The measurements were shown to lead to an accurate determination of relationships between these factors and production parameters. The variability indicator was found to dramatically affect the tangible performance measures such as home completion rates. This study provides for future analysis of the production homebuilding sector, which may lead to improvements in performance and a faster product delivery to homebuyers. 

  16. Exploring trade-offs between VMAT dose quality and delivery efficiency using a network optimization approach

    International Nuclear Information System (INIS)

    Salari, Ehsan; Craft, David; Wala, Jeremiah

    2012-01-01

    To formulate and solve the fluence-map merging procedure of the recently-published VMAT treatment-plan optimization method, called vmerge, as a bi-criteria optimization problem. Using an exact merging method rather than the previously-used heuristic, we are able to better characterize the trade-off between the delivery efficiency and dose quality. vmerge begins with a solution of the fluence-map optimization problem with 180 equi-spaced beams that yields the ‘ideal’ dose distribution. Neighboring fluence maps are then successively merged, meaning that they are added together and delivered as a single map. The merging process improves the delivery efficiency at the expense of deviating from the initial high-quality dose distribution. We replace the original merging heuristic by considering the merging problem as a discrete bi-criteria optimization problem with the objectives of maximizing the treatment efficiency and minimizing the deviation from the ideal dose. We formulate this using a network-flow model that represents the merging problem. Since the problem is discrete and thus non-convex, we employ a customized box algorithm to characterize the Pareto frontier. The Pareto frontier is then used as a benchmark to evaluate the performance of the standard vmerge algorithm as well as two other similar heuristics. We test the exact and heuristic merging approaches on a pancreas and a prostate cancer case. For both cases, the shape of the Pareto frontier suggests that starting from a high-quality plan, we can obtain efficient VMAT plans through merging neighboring fluence maps without substantially deviating from the initial dose distribution. The trade-off curves obtained by the various heuristics are contrasted and shown to all be equally capable of initial plan simplifications, but to deviate in quality for more drastic efficiency improvements. This work presents a network optimization approach to the merging problem. Contrasting the trade-off curves of the

  17. Exploring trade-offs between VMAT dose quality and delivery efficiency using a network optimization approach.

    Science.gov (United States)

    Salari, Ehsan; Wala, Jeremiah; Craft, David

    2012-09-07

    To formulate and solve the fluence-map merging procedure of the recently-published VMAT treatment-plan optimization method, called VMERGE, as a bi-criteria optimization problem. Using an exact merging method rather than the previously-used heuristic, we are able to better characterize the trade-off between the delivery efficiency and dose quality. VMERGE begins with a solution of the fluence-map optimization problem with 180 equi-spaced beams that yields the 'ideal' dose distribution. Neighboring fluence maps are then successively merged, meaning that they are added together and delivered as a single map. The merging process improves the delivery efficiency at the expense of deviating from the initial high-quality dose distribution. We replace the original merging heuristic by considering the merging problem as a discrete bi-criteria optimization problem with the objectives of maximizing the treatment efficiency and minimizing the deviation from the ideal dose. We formulate this using a network-flow model that represents the merging problem. Since the problem is discrete and thus non-convex, we employ a customized box algorithm to characterize the Pareto frontier. The Pareto frontier is then used as a benchmark to evaluate the performance of the standard VMERGE algorithm as well as two other similar heuristics. We test the exact and heuristic merging approaches on a pancreas and a prostate cancer case. For both cases, the shape of the Pareto frontier suggests that starting from a high-quality plan, we can obtain efficient VMAT plans through merging neighboring fluence maps without substantially deviating from the initial dose distribution. The trade-off curves obtained by the various heuristics are contrasted and shown to all be equally capable of initial plan simplifications, but to deviate in quality for more drastic efficiency improvements. This work presents a network optimization approach to the merging problem. Contrasting the trade-off curves of the merging

  18. Optimised Environmental Test Approaches in the GOCE Project

    Science.gov (United States)

    Ancona, V.; Giordano, P.; Casagrande, C.

    2004-08-01

    The Gravity Field and Steady-State Ocean Circulation Explorer (GOCE) is dedicated to measuring the Earth's gravity field and modelling the geoid with extremely high accuracy and spatial resolution. It is the first Earth Explorer Core mission to be developed as part of ESA's Living Planet Programme and is scheduled for launch in 2006. The program is managed by a consortium of European companies: Alenia Spazio, the prime contractor, Astrium GmbH, the platform responsible, Alcatel Space Industries and Laben, suppliers of the main payloads, respectively the Electrostatic Gravity Gradiometer (EGG) and the Satellite to Satellite Tracking Instrument (SSTI), actually a precise GPS receiver. The GOCE Assembly Integration and Verification (AIV) approach is established and implemented in order to demonstrate to the customer that the satellite design meets the applicable requirements and to qualify and accept from lower level up to system level. The driving keywords of "low cost" and "short schedule" program, call for minimizing the development effort by utilizing off-the-shelf equipment combined with a model philosophy lowering the number of models to be used. The paper will deal on the peculiarities of the optimized environmental test approach in the GOCE project. In particular it introduces the logic of the AIV approach and describe the foreseen tests at system level within the SM environmental test campaign, outlining the Quasi Static test performed in the frame of the SM sine vibration tests, and the PFM environmental test campaign pinpointing the deletion of the Sine Vibration test on PFM model. Furthermore the paper highlights how the Model and Test Effectiveness Database (MATD) can be utilized for the prediction of the new space projects like GOCE Satellite.

  19. Integrating a Project Management Approach to E-Business Application Course

    Science.gov (United States)

    Chen, Kuan C.; Chuang, Keh-Wen

    2008-01-01

    Teaching students project managements requires a hands-on approach. Incorporating project management concepts and processes into a student team Web development project adds a dimension that exposes students to the realities of effective Web development. This paper will describe the project management approach used in a Web development course in…

  20. Project W-521, waste feed delivery systems environmental permits and approvals plan

    International Nuclear Information System (INIS)

    TOLLEFSON, K.S.

    1999-01-01

    This document has been prepared to define the specific environmental requirements applicable to Project W-521. The document describes the permits and approvals necessary for the project to design, construct, and install planned upgrades, and provides a schedule of activities and provides cost estimates to complete the required permitting and approval activities

  1. Social Insurance for Delivery (Jampersal Policy in Indonesia: Culture-Based Approach for Improving Delivery by Health Workers in Rural Areas

    Directory of Open Access Journals (Sweden)

    Riswati Riswati

    2015-06-01

    Full Text Available Background: Jampersal program was launched in Indonesia in January of 2011 by Permenkes No.631/Menkes/PER/III/2011. The aim was to improve the coverage of antenatal care, delivery, postpartum care, postnatal, and family planning by health professionals free of charge. After over a year Jampersal program runs, The ANC figures of Jampersal utilization were still very low. Methods:Quantitative and qualitative research on socio- cultural factors in relation to the selection of health personnel by utilizing Jampersal conducted in 2012 which was then followed by a round table discussion to review the policy options related to the Jampersal utilization of the 6 rural districts. Results: Policy options suggested in Jampersal socialization activities need Intersectoral Commitment:The Ministry of Home Affairs, Ministry of Religious Affairs, and BKKBN, followed by a clear and decisive political commitment. They need active partnerships of the midwives, TBAs and cadres in Jampersal socialization. Midwives in the health center level should be prohibited from private practice, but the total amount of compensation of midwife in helping delivery should be adjusted. Regulations are required and procedures should be set for Jamkesnas, Jamkesda, and Jampersal; They need regulation on cooperation between the health centers staffs and village chiefs to further reinforce ID requirement;The transportation cost to refferal unit; TBAs services (division of task and cost; Financial restrictions to cover by Jampersal on second or third delivery. Additionally need a regulation of reward and punishment for midwives,TBAs and cadres involvement in serving pregnancy and delivery. In village level, they need to establish regulation, that TbaS AND Cadres should write the pregnat women data at the board office of village chiefts. Lastly, MoU between head of district health center and midwife assosiation related to midwife understanding of cultural approaches and on

  2. Improving immunization delivery using an electronic health record: the ImmProve project.

    Science.gov (United States)

    Bundy, David G; Persing, Nichole M; Solomon, Barry S; King, Tracy M; Murakami, Peter N; Thompson, Richard E; Engineer, Lilly D; Lehmann, Christoph U; Miller, Marlene R

    2013-01-01

    Though an essential pediatric preventive service, immunizations are challenging to deliver reliably. Our objective was to measure the impact on pediatric immunization rates of providing clinicians with electronic health record-derived immunization prompting. Operating in a large, urban, hospital-based pediatric primary care clinic, we evaluated 2 interventions to improve immunization delivery to children ages 2, 6, and 13 years: point-of-care, patient-specific electronic clinical decision support (CDS) when children overdue for immunizations presented for care, and provider-specific bulletins listing children overdue for immunizations. Overall, the proportion of children up to date for a composite of recommended immunizations at ages 2, 6, and 13 years was not different in the intervention (CDS active) and historical control (CDS not active) periods; historical immunization rates were high. The proportion of children receiving 2 doses of hepatitis A immunization before their second birthday was significantly improved during the intervention period. Human papillomavirus (HPV) immunization delivery was low during both control and intervention periods and was unchanged for 13-year-olds. For 14-year-olds, however, 4 of the 5 highest quarterly rates of complete HPV immunization occurred in the final year of the intervention. Provider-specific bulletins listing children overdue for immunizations increased the likelihood of identified children receiving catch-up hepatitis A immunizations (hazard ratio 1.32; 95% confidence interval 1.12-1.56); results for HPV and the composite of recommended immunizations were of a similar magnitude but not statistically significant. In our patient population, with high baseline uptake of recommended immunizations, electronic health record-derived immunization prompting had a limited effect on immunization delivery. Benefit was more clearly demonstrated for newer immunizations with lower baseline uptake. Copyright © 2013 Academic

  3. NNP-LANL Utilities - Condition Assessment and Project Approach

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, Grant Lorenz [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-11-21

    This report is a presentation on LANL Utilities & Transportation Asset Management; Utility Assets Overview; Condition Assessment; Utilities Project Nominations & Ranking; and Utilities Project Execution.

  4. Design and delivery of the diamond double double bend achromat project

    International Nuclear Information System (INIS)

    Kay, J.; Hammond, N. P.; Thomson, A.

    2016-01-01

    A major project is underway at Diamond Light Source to remove one of the 24 Double Bend Achromat (DBA) Storage Ring cells and replace it with a Double Double Bend Achromat (DDBA). In this way a new Insertion Device (ID) straight can be created and so ID light can be produced and delivered to a beamline previously only capable of receiving Bending Magnet (BM) radiation. This project is in support of the micro-focus Protein Crystallography (MX) beamline VMX-m which is scheduled to take users towards the end of 2017. This paper describes the Engineering Design of the DDBA project in more detail and gives the current status of the project.

  5. Design and delivery of the diamond double double bend achromat project

    Energy Technology Data Exchange (ETDEWEB)

    Kay, J., E-mail: jim.kay@diamond.ac.uk; Hammond, N. P.; Thomson, A. [Diamond Light Source, Didcot, Oxfordshire, UK, OX11 0DE (United Kingdom)

    2016-07-27

    A major project is underway at Diamond Light Source to remove one of the 24 Double Bend Achromat (DBA) Storage Ring cells and replace it with a Double Double Bend Achromat (DDBA). In this way a new Insertion Device (ID) straight can be created and so ID light can be produced and delivered to a beamline previously only capable of receiving Bending Magnet (BM) radiation. This project is in support of the micro-focus Protein Crystallography (MX) beamline VMX-m which is scheduled to take users towards the end of 2017. This paper describes the Engineering Design of the DDBA project in more detail and gives the current status of the project.

  6. Exploring the knowledge ‘base’ of practitioners in the delivery of sustainable regeneration projects

    OpenAIRE

    Akotia, Julius; Opoku, Alex; Egbu, Charles; Fortune, Chris

    2016-01-01

    In recent years, sustainable regeneration has been recognised as being of major economic and social concern in the world. In the UK for instance, government has initiated a number of policies and evaluation methods to deal with some of the environmental problems associated with regeneration projects. However, the post construction evaluation of these projects has often resulted in them being seen as not achieving their set objectives. Attempts aimed at evaluating the impact of sustainability ...

  7. Innovative developments and managerial factors as key enablers of deepwater riser project delivery

    OpenAIRE

    Belik, Maxim

    2016-01-01

    Master's thesis in Offshore technology: industrial asset management The oil and gas industry is currently facing unprecedented challenges because of a negative impact from a declined commodity pricing trend. As the industry tackles deeper and more complex projects, the use of innovative technology to resolve technical challenges becomes an essential project enabler. Integrating proven designs and products with new technologies is a basic requirement in present business environment. Com...

  8. International project marketing: an introduction to the INPM approach

    DEFF Research Database (Denmark)

    Skaates, Maria Anne; Tikkanen, Henrikki

    2003-01-01

    marketing takes place. First, we discuss various definitions of projects and project marketing. Second, we consider the implications of three specific features of project business--discontinuity, uniqueness, and complexity--over multiple projects. Third, we assess three overlapping types of postures......Projects are often sold and procured. Therefore this paper reviews recent contributions of the International Network for Project Marketing and Systems Selling (INPM), emphasising the connection between the business relationships of individual projects and the wider environment in which project...... that project-selling firms can adopt in relation to their marketing activities. Finally, we make some suggestions for practitioners responsible for marketing projects and discuss avenues for future academic work in project marketing....

  9. A cytometry microparticle platform approach for screening tobacco microRNA changes after agrobacterium delivery

    Energy Technology Data Exchange (ETDEWEB)

    Powell, Joshua D.; Chen, Qiang; Mason, Hugh S.

    2016-08-01

    Abstract Key message nta-miR-398 is significantly up-regulated while nta-miR-428d is significantly down-regulated in tobacco after agroinfiltration AbstractMicroRNAs are a class of non-coding regulatory RNAs that can modulate development as well as alter innate antiviral defenses in plants. In this study we explored host changes at the microRNA level within tobacco (Nicotiana benthamiana) after expression of a recombinant anti-Ebola GP1 antibody through Agrobacterium tumefaciens agroinfiltration delivery. A multiplex nanoparticle-based cytometry assay tracked the host expression changes of 53 tobacco microRNAs. Our results revealed that the most abundant microRNAs in actively growing leaves corresponded to nanoparticle probes specific to nta-mir-6149 and nta-miR-168b. After agroinfiltration, probes targeting nta-mir-398 and nta-mir-482d were significantly altered in their respective expression levels and were further verified through RT-qPCR analysis. To our knowledge this study is the first to profile microRNA expression in tobacco after agroinfiltration using a multiplex nanoparticle approach.

  10. Digital contract approach for consistent and predictable multimedia information delivery in electronic commerce

    Science.gov (United States)

    Konana, Prabhudev; Gupta, Alok; Whinston, Andrew B.

    1997-01-01

    A pure 'technological' solution to network quality problems is incomplete since any benefits from new technologies are offset by the demand from exponentially growing electronic commerce ad data-intensive applications. SInce an economic paradigm is implicit in electronic commerce, we propose a 'market-system' approach to improve quality of service. Quality of service for digital products takes on a different meaning since users view quality of service differently and value information differently. We propose a framework for electronic commerce that is based on an economic paradigm and mass-customization, and works as a wide-area distributed management system. In our framework, surrogate-servers act as intermediaries between information provides and end- users, and arrange for consistent and predictable information delivery through 'digital contracts.' These contracts are negotiated and priced based on economic principles. Surrogate servers pre-fetched, through replication, information from many different servers and consolidate based on demand expectations. In order to recognize users' requirements and process requests accordingly, real-time databases are central to our framework. We also propose that multimedia information be separated into slowly changing and rapidly changing data streams to improve response time requirements. Surrogate- servers perform the tasks of integration of these data streams that is transparent to end-users.

  11. Project Report on Development of a Safeguards Approach for Pyroprocessing

    Energy Technology Data Exchange (ETDEWEB)

    Robert Bean

    2010-09-01

    The Idaho National Laboratory has undertaken an effort to develop a standard safeguards approach for international commercial pyroprocessing facilities. This report details progress for the fiscal year 2010 effort. A component by component diversion pathway analysis has been performed, and has led to insight on the mitigation needs and equipment development needed for a valid safeguards approach. The effort to develop an in-hot cell detection capability led to the digital cloud chamber, and more importantly, the significant potential scientific breakthrough of the inverse spectroscopy algorithm, including the ability to identify energy and spatial location of gamma ray emitting sources with a single, non-complex, stationary radiation detector system. Curium measurements were performed on historical and current samples at the FCF to attempt to determine the utility of using gross neutron counting for accountancy measurements. A solid cost estimate of equipment installation at FCF has been developed to guide proposals and cost allocations to use FCF as a test bed for safeguards measurement demonstrations. A combined MATLAB and MCNPX model has been developed to perform detector placement calculations around the electrorefiner. Early harvesting has occurred wherein the project team has been requested to provide pyroprocessing technology and safeguards short courses.

  12. Integrating evidence into policy and sustainable disability services delivery in western New South Wales, Australia: the 'wobbly hub and double spokes' project.

    Science.gov (United States)

    Veitch, Craig; Lincoln, Michelle; Bundy, Anita; Gallego, Gisselle; Dew, Angela; Bulkeley, Kim; Brentnall, Jennie; Griffiths, Scott

    2012-03-21

    Policy that supports rural allied health service delivery is important given the shortage of services outside of Australian metropolitan centres. The shortage of allied health professionals means that rural clinicians work long hours and have little peer or service support. Service delivery to rural and remote communities is further complicated because relatively small numbers of clients are dispersed over large geographic areas. The aim of this five-year multi-stage project is to generate evidence to confirm and develop evidence-based policies and to evaluate their implementation in procedures that allow a regional allied health workforce to more expeditiously respond to disability service need in regional New South Wales, Australia. The project consists of four inter-related stages that together constitute a full policy cycle. It uses mixed quantitative and qualitative methods, guided by key policy concerns such as: access, complexity, cost, distribution of benefits, timeliness, effectiveness, equity, policy consistency, and community and political acceptability. Stage 1 adopts a policy analysis approach in which existing relevant policies and related documentation will be collected and reviewed. Policy-makers and senior managers within the region and in central offices will be interviewed about issues that influence policy development and implementation. Stage 2 uses a mixed methods approach to collecting information from allied health professionals, clients, and carers. Focus groups and interviews will explore issues related to providing and receiving allied health services. Discrete Choice Experiments will elicit staff and client/carer preferences. Stage 3 synthesises Stage 1 and 2 findings with reference to the key policy issues to develop and implement policies and procedures to establish several innovative regional workforce and service provision projects. Stage 4 uses mixed methods to monitor and evaluate the implementation and impact of new or adapted

  13. Stabilization and delivery approaches for protein and peptide pharmaceuticals: an extensive review of patents.

    Science.gov (United States)

    Swain, Suryakanta; Mondal, Debanik; Beg, Sarwar; Patra, Chinam Niranjan; Dinda, Subas Chandra; Sruti, Jammula; Rao, Muddana Eswara Bhanoji

    2013-04-01

    Proteins and peptides are the building blocks of human body and act as the arsenal to combat against the invading pathogenic organisms for treatment and management of diseases. Majority of such biomacromolecules are synthesized by the human body itself. However, entry of disease causing pathogens causes misleading in the synthesis of desired proteins for antibody formation. In such alarming situations, the delivery of requisite protein and peptide from external source helps in augmenting the body's immunity. The major drawbacks underlying poor biopharmaceutical performance of high molecular weight protein and peptide drugs are due to poor oral absorption, formulation stability, degradation in the gastric milieu, susceptible to presystemic metabolism. Numerous literature recounts the application of myriad drug delivery strategies for the effective delivery of protein and peptides viz. parentral, oral, transdermal, nasal, pulmonary, rectal, buccal and ocular drug delivery systems. There are many reviews on various delivery strategies for protein and peptide pharmaceuticals, but the present review article provides a bird's eye view on various novel drug delivery systems used for enhanced delivery of protein and peptide pharmaceuticals in the light of patent literature. Apart from this, the present manuscript endeavor provides idea on possible causes and major degradation pathways responsible for poor stability of protein and peptide drugs along with recent market instances on them utilizing novel drug delivery systems.

  14. Transdermal and transbuccal drug delivery systems: enhancement using iontophoretic and chemical approaches.

    Science.gov (United States)

    Hu, Longsheng; Silva, Sérgio M C; Damaj, Bassam B; Martin, Richard; Michniak-Kohn, Bozena B

    2011-12-12

    We investigated the enhancement effect of chemical enhancers and iontophoresis on the in vitro transdermal and transbuccal delivery of lidocaine HCl (LHCl), nicotine hydrogen tartrate (NHT), and diltiazem HCl (DHCl) using porcine skin and buccal tissues. Dodecyl 2-(N,N-dimethylamino) propionate (DDAIP), dodecyl-2-(N,N-dimethylamino) propionate hydrochloride (DDAIP HCl), N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane (Br-iminosulfurane), and azone (laurocapram) were used as chemical enhancers. The study results showed that the application of iontophoresis at either 0.1 mA or 0.3 mA significantly enhanced transdermal and transmucosal delivery of LHCl, NHT and DHCl. It was also demonstrated that iontophoresis had a more pronounced enhancement effect on transdermal delivery than on transbuccal delivery of LHCl, NHT and DHCl. In addition, DDAIP HCl was found to be the most effective enhancer for transbuccal delivery of LHCl and NHT. Copyright © 2011 Elsevier B.V. All rights reserved.

  15. Applying a life cycle approach to project management methods

    OpenAIRE

    Biggins, David; Trollsund, F.; Høiby, A.L.

    2016-01-01

    Project management is increasingly important to organisations because projects are the method\\ud by which organisations respond to their environment. A key element within project management\\ud is the standards and methods that are used to control and conduct projects, collectively known as\\ud project management methods (PMMs) and exemplified by PRINCE2, the Project Management\\ud Institute’s and the Association for Project Management’s Bodies of Knowledge (PMBOK and\\ud APMBOK. The purpose of t...

  16. Developing and pre-testing a decision board to facilitate informed choice about delivery approach in uncomplicated pregnancy

    Directory of Open Access Journals (Sweden)

    Wood Stephen

    2009-10-01

    Full Text Available Abstract Background The rate of caesarean sections is increasing worldwide, yet medical literature informing women with uncomplicated pregnancies about relative risks and benefits of elective caesarean section (CS compared with vaginal delivery (VD remains scarce. A decision board may address this gap, providing systematic evidence-based information so that patients can more fully understand their treatment options. The objective of our study was to design and pre-test a decision board to guide clinical discussions and enhance informed decision-making related to delivery approach (CS or VD in uncomplicated pregnancy. Methods Development of the decision board involved two preliminary studies to determine women's preferred mode of risk presentation and a systematic literature review for the most comprehensive presentation of medical risks at the time (VD and CS. Forty women were recruited to pre-test the tool. Eligible subjects were of childbearing age (18-40 years but were not pregnant in order to avoid raising the expectation among pregnant women that CS was a universally available birth option. Women selected their preferred delivery approach and completed the Decisional Conflict Scale to measure decisional uncertainty before and after reviewing the decision board. They also answered open-ended questions reflecting what they had learned, whether or not the information had helped them to choose between birth methods, and additional information that should be included. Descriptive statistics were used to analyse sample characteristics and women's choice of delivery approach pre/post decision board. Change in decisional conflict was measured using Wilcoxon's sign rank test for each of the three subscales. Results The majority of women reported that they had learned something new (n = 37, 92% and that the tool had helped them make a hypothetical choice between delivery approaches (n = 34, 85%. Women wanted more information about neonatal risks and

  17. Nonnegative least-squares image deblurring: improved gradient projection approaches

    Science.gov (United States)

    Benvenuto, F.; Zanella, R.; Zanni, L.; Bertero, M.

    2010-02-01

    The least-squares approach to image deblurring leads to an ill-posed problem. The addition of the nonnegativity constraint, when appropriate, does not provide regularization, even if, as far as we know, a thorough investigation of the ill-posedness of the resulting constrained least-squares problem has still to be done. Iterative methods, converging to nonnegative least-squares solutions, have been proposed. Some of them have the 'semi-convergence' property, i.e. early stopping of the iteration provides 'regularized' solutions. In this paper we consider two of these methods: the projected Landweber (PL) method and the iterative image space reconstruction algorithm (ISRA). Even if they work well in many instances, they are not frequently used in practice because, in general, they require a large number of iterations before providing a sensible solution. Therefore, the main purpose of this paper is to refresh these methods by increasing their efficiency. Starting from the remark that PL and ISRA require only the computation of the gradient of the functional, we propose the application to these algorithms of special acceleration techniques that have been recently developed in the area of the gradient methods. In particular, we propose the application of efficient step-length selection rules and line-search strategies. Moreover, remarking that ISRA is a scaled gradient algorithm, we evaluate its behaviour in comparison with a recent scaled gradient projection (SGP) method for image deblurring. Numerical experiments demonstrate that the accelerated methods still exhibit the semi-convergence property, with a considerable gain both in the number of iterations and in the computational time; in particular, SGP appears definitely the most efficient one.

  18. Reinventing project management the diamond approach to successful growth & innovation

    CERN Document Server

    Shenhar, Aaron J.

    2007-01-01

    Projects are the engines that drive innovation from idea to commercialization. In fact, the number of projects in most organizations today is expanding while operations is shrinking. Yet, since many companies still focus on operational excellence and efficiency, most projects fail--largely because conventional project management concepts cannot adapt to a dynamic business environment. Moreover, top managers neglect their company's project activity, and line managers treat all their projects alike--as part of operations. Based on an unprecedented study of more than 600 projects in a variety of businesses and organizations around the globe, "Reinventing Project Management" provides a new and highly adaptive model for planning and managing projects to achieve superior business results.

  19. River Protection Project waste feed delivery program technical performance measurement assessment plan

    International Nuclear Information System (INIS)

    O'TOOLE, S.M.

    1999-01-01

    This plan establishes a formal technical performance-monitoring program. Technical performance is assessed by establishing requirements based performance goals at the beginning of a program and routinely evaluating progress in meeting these goals at predetermined milestones throughout the project life cycle

  20. Title IV Quality Control Project, Stage II. Management Option II: Delivery System Quality Improvements.

    Science.gov (United States)

    Advanced Technology, Inc., Reston, VA.

    Stage Two of the Title IV Quality Control Project is an integrated study of quality in five related Federal financial aid programs for postsecondary students. Section 1 of the paper establishes a framework for defining quality improvements, in order to identify the types of changes that would tend to improve quality across all facets of the…

  1. Information interoperability and interdisciplinarity: the BIM approach from SEEMPubS project to DIMMER project

    Directory of Open Access Journals (Sweden)

    Anna Osello

    2013-12-01

    Full Text Available Design, implementation and management constitute the cornerstones of the building process and the current trend, albeit still at an embryonic state in Italy, is represented by the application of a problem-solving approach combining integrated analysis and research between interdisciplinary professionals able to integrate their know-how and experience. The project SEEMPubS (Smart Energy Efficient Middleware for Public Spaces, which ended in August 2013, investigated the theoretical and operational possibility of using a network of sensors to monitor energy consumption and raise awareness of this issue among end-users in academic and working places. The project DIMMER (District Information Modeling and Management for Energy Reduction, that kicked off on October 01st, 2013, represents its evolution, as the research extends from buildings (building scale to the neighborhood (urban scale, simultaneously expanding the areas of study. Data and information to be processed and analyzed call, in this case, for a reconsideration of the activities to be carried out, through the use of innovative instruments and procedures to ensure correct information flow and optimal data management. For this purpose, we adopted the BIM methodology (Building Information Modeling for digital representation and modeling of our case studies, facility management and analysis of interoperability between different software applications, investigating how the tools currently available on the market and the interdisciplinary collaboration between professionals from different areas may constitute the standard for tomorrow’s communication.

  2. Sustainability: An Ethical Approach Towards Project Business Success

    OpenAIRE

    G. S. Dangayach

    2011-01-01

    For any country the project management has been a vital part for its development. The highly competitive business world has created tremendous pressure on the project managers to achieve success. The pressure is derived from survival and profit building in business organizations which compels the project managers to pursue unethical practices. As a result unethical activities in business projects can be found easily where situations or issues arise due to dubious business...

  3. Facilitating value creation and delivery in construction projects via front-end loading

    DEFF Research Database (Denmark)

    Thyssen, Mikael Hygum; Emmitt, Stephen; Bonke, Sten

    2008-01-01

    -struction phase of the building projects. However it is in the early design phase that client value is established and the scene is set for everything that follows. Productivity in the construction phase is strongly dependent on performance of the design team and real client value will not be achieved...... if the building design does not meet client expectations (understanding the client as a wide range of stakeholders). Therefore a holistic view of the building process should be applied with a greater focus on the design phase and value creation. In Denmark a consulting engineering company has together...... with a major contractor developed a value based work-shop model that seeks to capture client values and manage the subsequent stages of the building process within a Lean framework striving to maximize value and reduce waste. This paper reports the initial findings of a joint research project between academic...

  4. Progress of IFERC project in the Broader Approach Activities

    International Nuclear Information System (INIS)

    Araki, M.; Sakamoto, Y.; Hayashi, K.; Ohuchi, R.; Nishitani, T.

    2010-01-01

    For contributing to the ITER project and promoting a possible early realization of DEMO, since 2007 the International Fusion Energy Research Centre (IFERC) shall perform the activities on (1) DEMO Design and R and D Coordination, (2) Computational Simulation Centre, and (3) ITER Remote Experimentation Centre in the framework under the agreement between the Government of Japan and the European Atomic Energy Community for the joint implementation of the Broader Approach Activities in the field of fusion energy. The DEMO Design activity aims at establishing a common basis for DEMO Design, including design features of DEMO, possible common concepts of DEMO, a roadmap for DEMO, and so on. Based on the common interest of EU and Japan toward DEMO, the DEMO R and D activities have been planned and carried out for the areas which are related to DEMO blanket development: SiC/SiC composites, tritium technology, materials engineering, advanced neutron multiplier, and advanced tritium breeders for DEMO blanket. In the activity of the Computational Simulation Centre, the objective is to provide and exploit a supercomputer for large scale simulation activities to analyse experimental data on fusion plasmas, prepare scenarios for ITER operation, predict the performance of the ITER facilities and contribute to the DEMO Design.

  5. Discovery of Cationic Polymers for Non-viral Gene Delivery using Combinatorial Approaches

    Science.gov (United States)

    Barua, Sutapa; Ramos, James; Potta, Thrimoorthy; Taylor, David; Huang, Huang-Chiao; Montanez, Gabriela; Rege, Kaushal

    2015-01-01

    Gene therapy is an attractive treatment option for diseases of genetic origin, including several cancers and cardiovascular diseases. While viruses are effective vectors for delivering exogenous genes to cells, concerns related to insertional mutagenesis, immunogenicity, lack of tropism, decay and high production costs necessitate the discovery of non-viral methods. Significant efforts have been focused on cationic polymers as non-viral alternatives for gene delivery. Recent studies have employed combinatorial syntheses and parallel screening methods for enhancing the efficacy of gene delivery, biocompatibility of the delivery vehicle, and overcoming cellular level barriers as they relate to polymer-mediated transgene uptake, transport, transcription, and expression. This review summarizes and discusses recent advances in combinatorial syntheses and parallel screening of cationic polymer libraries for the discovery of efficient and safe gene delivery systems. PMID:21843141

  6. Public Private Partnerships: A possible alternative for delivery of infrastructure projects in Africa

    OpenAIRE

    Salim Bwanali; Pantaleo Rwelamila

    2017-01-01

    It is estimated that Africa needs $93 billion annually until 2020 in order to bridge its infrastructure deficit. It is through significant investment in infrastructure development that economic growth and poverty alleviation can be enhanced. However central to all construction projects is an effective and sustainable procurement system. There is a notable shift by some African governments to turn to the private sector to design, build, finance and operate infrastructure facilities previously ...

  7. A hierarchical approach to multi-project planning under uncertainty

    NARCIS (Netherlands)

    Leus, R.; Wullink, Gerhard; Hans, Elias W.; Herroelen, W.

    2004-01-01

    We survey several viewpoints on the management of the planning complexity of multi-project organisations under uncertainty. A positioning framework is proposed to distinguish between different types of project-driven organisations, which is meant to aid project management in the choice between the

  8. El Metodo Llamado Proyecto (The Project Approach). ERIC Digest.

    Science.gov (United States)

    Katz, Lilian G.

    A project is an in-depth investigation of a topic worth learning more about, usually undertaken by a group of children within a class. The goal of a project is to learn more about a topic rather than to find answers to questions posed by a teacher. Project work is complementary to the systematic parts of a curriculum. Whereas systematic…

  9. A hierarchical approach to multi-project planning under uncertainty

    NARCIS (Netherlands)

    Hans, Elias W.; Herroelen, W.; Wullink, Gerhard; Leus, R.

    2007-01-01

    We survey several viewpoints on the management of the planning complexity of multi-project organisations under uncertainty. Based on these viewpoints we propose a positioning framework to distinguish between different types of project-driven organisations. This framework is meant to aid project

  10. TARGET APPROACH TO PROJECT FINANCING TRANCHES OF INNOVATIONS AND INVESTMENTS

    Directory of Open Access Journals (Sweden)

    Galina G. Balayan

    2015-01-01

    Full Text Available The article concerns the main provisions of the financing tranches for innovative projects. The article is of methodological nature. It gives theoretically justified, universal for any of the project stages and their characteristics needed to calculate efficiency project financing tranches.

  11. The impact of a prevention delivery system on perceived social capital: the PROSPER project.

    Science.gov (United States)

    Chilenski, Sarah M; Ang, Patricia M; Greenberg, Mark T; Feinberg, Mark E; Spoth, Richard

    2014-04-01

    The current study examined the impact of the PROSPER delivery system for evidence-based prevention programs on multiple indicators of social capital in a rural and semi-rural community sample. Utilizing a randomized blocked design, 317 individuals in 28 communities across two states were interviewed at three time points over the course of 2.5 years. Bridging, linking, and the public life skills forms of social capital were assessed via community members' and leaders' reports on the perceptions of school functioning and the Cooperative Extension System, collaboration among organizations, communication and collaboration around youth problems, and other measures. Longitudinal mixed model results indicate significant improvements in some aspects of bridging and linking social capital in PROSPER intervention communities. Given the strength of the longitudinal and randomized research design, results advance prevention science by suggesting that community collaborative prevention initiatives can significantly impact community social capital in a rural and semi-rural sample. Future research should further investigate changes in social capital in different contexts and how changes in social capital relate to other intervention effects.

  12. How project approach influences adoption of SWC by farmers, examples from southern Mali

    NARCIS (Netherlands)

    Bodnar, F.; Schrader, T.; Campen, Van W.

    2006-01-01

    Choices in project approach affect the continuation of soil and water conservation (SWC) after project withdrawal, and thus the sustainability and cost effectiveness of the project. A SWC project was carried out in southern Mali between 1986 and 1998. Its features were the promotion of cheap and

  13. Projection operator approach to the self-energy

    International Nuclear Information System (INIS)

    Capuzzi, F.; Mahaux, C.

    1996-01-01

    Feshbach close-quote s projection operator formalism is extended to the description of the self-energy. This necessitates the introduction of open-quote open-quote extended close-quote close-quote projection operators. They act within an open-quote open-quote extended close-quote close-quote Hilbert space in which the number of nucleons is not fixed. The compact formula derived for the self-energy is formally similar to Feshbach close-quote s original expression of the open-quote open-quote generalized close-quote close-quote optical-model potential. The theory is formulated in the nuclear case, but it also applies to atomic systems. It covers both the open-quote open-quote retarded close-quote close-quote and the open-quote open-quote time-ordered close-quote close-quote Green close-quote s functions, and the open-quote open-quote proper close-quote close-quote and open-quote open-quote improper close-quote close-quote self-energies. It is first worked out in a stationary formalism, in order to better exhibit its analogy with Feshbach close-quote s original theory of the generalized optical-model potential. The main results are then also derived in a time-dependent framework. It is shown that, in finite systems, Dyson close-quote s equation does not uniquely determine the self-energy, in contrast to common assumption. However, the difference between the various possibilities has little practical consequence. We exhibit the relationship between the present approach and a recent open-quote open-quote configuration interaction formulation of the Dyson equation.close-quote close-quote Contact is also established with the open-quote open-quote linked-cluster close-quote close-quote perturbation expansion of the self-energy in powers of the strength of the nucleon endash nucleon interaction. Copyright copyright 1996 Academic Press, Inc

  14. 75 FR 9638 - Surface Transportation Project Delivery Pilot Program; Caltrans Audit Report

    Science.gov (United States)

    2010-03-03

    ... practice on a case- by-case basis. The FHWA recommends that Caltrans develop a departmentwide, holistic corrective action management approach and system that will develop and implement an internal process review... the Pilot Program. During the on-site audit, Caltrans staff and management continued to express...

  15. A Framework for Six Sigma Project Selection in Higher Educational Institutions, Using a Weighted Scorecard Approach

    Science.gov (United States)

    Holmes, Monica C.; Jenicke, Lawrence O.; Hempel, Jessica L.

    2015-01-01

    Purpose: This paper discusses the importance of the Six Sigma selection process, describes a Six Sigma project in a higher educational institution and presents a weighted scorecard approach for project selection. Design/Methodology/Approach: A case study of the Six Sigma approach being used to improve student support at a university computer help…

  16. Exploration of Exploitation Approaches of European Projects on ICT and Foreign Language Learning: the CEFcult project case

    NARCIS (Netherlands)

    Rusman, Ellen; Rajagopal, Kamakshi; Stoyanov, Slavi; Van Maele, Jan

    2011-01-01

    Rusman, E., Rajagopal, K., Stoyanov, S., & Van Maele, J. (2011, 20-21 October). Exploration of Exploitation Approaches of European Projects on ICT and Foreign Language Learning: the CEFcult project case. Paper presented at the 4th International Conference ICT for Language Learning, Florence, Italy.

  17. Exploration of Exploitation Approaches of European Projects on ICT and Foreign Language Learning: the CEFcult project case

    OpenAIRE

    Rusman, Ellen; Rajagopal, Kamakshi; Stoyanov, Slavi; Van Maele, Jan

    2011-01-01

    Rusman, E., Rajagopal, K., Stoyanov, S., & Van Maele, J. (2011, 20-21 October). Exploration of Exploitation Approaches of European Projects on ICT and Foreign Language Learning: the CEFcult project case. Paper presented at the 4th International Conference ICT for Language Learning, Florence, Italy. Available at: http://www.pixel-online.net/ICT4LL2011/conferenceproceedings.php

  18. Assessment Of Various Activities Indicators Made Available To Farmers For Participation Through Fadama Iii Agricultural Project Delivery Agency In Bayelsa State Nigeria

    Directory of Open Access Journals (Sweden)

    Ominikari

    2017-09-01

    Full Text Available The study assessed the activities made available to farmers for participation through Fadama III Project in Bayelsa State. Objective of the study was activities made available to farmers through National Fadama III Agricultural project delivery agency. Purposive sampling technique was used to select One-Hundred and fifty 150 farmers that participated and 150 staff from the delivery agency. Data were collected with a structured questionnaire. The data collected was analyzed using frequency count percentage mean X amp773 standard deviation STD while z-test was used to test the null hypotheses at 0.05 level of significance. Farmers in the state truly believe in the existence of various activities in Fadama III project in the state as being made available to them through the delivery agency. The result of the z-test showed that the mean response of the farmers in Fadama III projects was 2.986 while the mean response of the delivery agency was 3.793 there was significant difference z -20.245 in the mean score response of the delivery agency and participants of National Fadama III Agricultural Project on the various activities that were made available to the farmers at P amp8804 0.05. The study therefore recommended that National Fadama III Project activities should be reorganized to be of great benefit to the farmers proper training in all the activities should be made available for effective participation empower the participants to improve their income level and to move them away from poverty by improving their standard of living by reorganizing the Fadama III Project.

  19. Delivery of Functionality in Complex Food Systems: Physically inspired approaches from nanoscale to microscale, Paris 14 to 17 July, 2015.

    Science.gov (United States)

    Relkin, Perla

    2016-10-01

    The 6th international symposium in the series "Delivery of Functionality in Complex Food Systems: Physically inspired approaches from nanoscale to microscal" was held in the heart of Paris from 14 to 17 July, 2015. It brought together PhD students, academic food researchers and industrials from diversified food sectors. The scientific sessions of this meeting were constructed around important topics dealing with 1) Engineering of tailored-made structures in bio-based systems; 2) Complexity and emergent phenomena in the integrative food science; 3) Investigation of nano and microstructures in the bulk and at interfaces; 4) Modeling approaches from bio-molecules and matrix structures to functionality; 5) Tuning binding & release of bioactive compounds by matrix modulation, and finally; 6) Tuning the delivery of functionality to the body. These topics were selected to cover different scientific fields and to show the contribution of food physical structures to development of health- and plaisure-supporting food functions. The oral communications were all introduced by key note speakers and they were all illustrated by outstanding high quality short communications. One of the most original features of this symposium was the increasing number of presentations using multiscale and modeling approaches illustrating the concept of complexity and emergent phenomena integrative food science. These highlighted the importance of studies on interactions between structure properties of engineered delivery systems and human body (sensory properties, digestion, release, bioavailability and bioaccessibility). Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Validation of a simple distributed sediment delivery approach in selected sub-basins of the River Inn catchment area

    Science.gov (United States)

    Reid, Lucas; Kittlaus, Steffen; Scherer, Ulrike

    2015-04-01

    For large areas without highly detailed data the empirical Universal Soil Loss Equation (USLE) is widely used to quantify soil loss. The problem though is usually the quantification of actual sediment influx into the rivers. As the USLE provides long-term mean soil loss rates, it is often combined with spatially lumped models to estimate the sediment delivery ratio (SDR). But it gets difficult with spatially lumped approaches in large catchment areas where the geographical properties have a wide variance. In this study we developed a simple but spatially distributed approach to quantify the sediment delivery ratio by considering the characteristics of the flow paths in the catchments. The sediment delivery ratio was determined using an empirical approach considering the slope, morphology and land use properties along the flow path as an estimation of travel time of the eroded particles. The model was tested against suspended solids measurements in selected sub-basins of the River Inn catchment area in Germany and Austria, ranging from the high alpine south to the Molasse basin in the northern part.

  1. Conflict Approaches of Effective Project Manager in the Upstream Sector of Indonesian Oil & Gas Industry

    OpenAIRE

    Adhi Cahyono; Yanki Hartijasti

    2012-01-01

    Conflict can be functional or dysfunctional to the organization’s performance. This study focused on the relationship between conflict approaches implemented by the project manager based on project team member’s perception on the effectiveness of the project manager in managing project’s conflict. Questionnaires were modified from Barker et al. (1988) to measure conflict management approaches and outcomes of managing project conflict. Data were gathered from 57 respondents w...

  2. Magnetic Nanoparticle Facilitated Drug Delivery for Cancer Therapy with Targeted and Image-Guided Approaches.

    Science.gov (United States)

    Huang, Jing; Li, Yuancheng; Orza, Anamaria; Lu, Qiong; Guo, Peng; Wang, Liya; Yang, Lily; Mao, Hui

    2016-06-14

    With rapid advances in nanomedicine, magnetic nanoparticles (MNPs) have emerged as a promising theranostic tool in biomedical applications, including diagnostic imaging, drug delivery and novel therapeutics. Significant preclinical and clinical research has explored their functionalization, targeted delivery, controllable drug release and image-guided capabilities. To further develop MNPs for theranostic applications and clinical translation in the future, we attempt to provide an overview of the recent advances in the development and application of MNPs for drug delivery, specifically focusing on the topics concerning the importance of biomarker targeting for personalized therapy and the unique magnetic and contrast-enhancing properties of theranostic MNPs that enable image-guided delivery. The common strategies and considerations to produce theranostic MNPs and incorporate payload drugs into MNP carriers are described. The notable examples are presented to demonstrate the advantages of MNPs in specific targeting and delivering under image guidance. Furthermore, current understanding of delivery mechanisms and challenges to achieve efficient therapeutic efficacy or diagnostic capability using MNP-based nanomedicine are discussed.

  3. Nanocrystal: a novel approach to overcome skin barriers for improved topical drug delivery.

    Science.gov (United States)

    Patel, Viral; Sharma, Om Prakash; Mehta, Tejal

    2018-04-01

    Skin is an important route of drug delivery for the treatment of various dermatological conditions. The advent of nanotechnology is paving the roadmaps for topical drug delivery by providing sustained release as well as maintaining a localized effect, outweighing the toxicity concern. Area covered: This review highlighted the morphology of skin, its barrier nature as well as drug penetration pathways after topical application of formulations. The existing methods to improve topical drug delivery, by infringing or permeating the skin barriers, are discussed. This context concretes the foundation to accentuate the need for the development of nanocrystal-based topical formulation. The mechanism of drug release, immediate as well as sustained release, after topical administration of drug nanocrystals is also elaborated. The special emphasis is given on the breakthrough achieved, in topical drug delivery using drug nanocrystals, so far in the plethora of literature, patents, and products, under clinical trial as well as in the market. Expert opinion: The current research on nanocrystals for topical drug delivery is highlighting the breakthroughs achieved so far. The output of these research envisages that topical nanocrystals based formulations can be a novel strategy for the drugs which are facing solubility, bioavailability and toxicity concerns.

  4. Evaluation model of project complexity for large-scale construction projects in Iran - A Fuzzy ANP approach

    Directory of Open Access Journals (Sweden)

    Aliyeh Kazemi

    2016-09-01

    Full Text Available Construction projects have always been complex. By growing trend of this complexity, implementations of large-scale constructions become harder. Hence, evaluating and understanding these complexities are critical. Correct evaluation of a project complication can provide executives and managers with good source to use. Fuzzy analytic network process (ANP is a logical and systematic approach toward defining, evaluation, and grading. This method allows for analyzing complex systems, and determining complexity of them. In this study, by taking advantage of fuzzy ANP, effective indexes for development of complications in large-scale construction projects in Iran have been determined and prioritized. The results show socio-political, project system interdependencies, and technological complexity indexes ranked top to three. Furthermore, in comparison of three main huge projects: commercial-administrative, hospital, and skyscrapers, the hospital project had been evaluated as the most complicated. This model is beneficial for professionals in managing large-scale projects.

  5. From a declaration of values to the creation of value in global health: a report from Harvard University's Global Health Delivery Project.

    Science.gov (United States)

    Kim, J Y; Rhatigan, J; Jain, S H; Weintraub, R; Porter, M E

    2010-01-01

    To make best use of the new dollars available for the treatment of disease in resource-poor settings, global health practice requires a strategic approach that emphasises value for patients. Practitioners and global health academics should seek to identify and elaborate the set of factors that drives value for patients through the detailed study of actual care delivery organisations in multiple settings. Several frameworks can facilitate this study, including the care delivery value chain. We report on our efforts to catalyse the study of health care delivery in resource-limited settings in the hope that this inquiry will lead to insights that can improve the health of the neediest worldwide.

  6. The nasal approach to delivering treatment for brain diseases: an anatomic, physiologic, and delivery technology overview.

    Science.gov (United States)

    Djupesland, Per G; Messina, John C; Mahmoud, Ramy A

    2014-06-01

    The intricate pathophysiology of brain disorders, difficult access to the brain, and the complexity and high risks and costs of drug development represent major hurdles for improving therapies. Nose-to-brain drug transport offers an attractive alternative or addition to formulation-only strategies attempting to enhance drug penetration into the CNS. Although still a matter of controversy, many studies in animals claim direct nose-to-brain transport along the olfactory and trigeminal nerves, circumventing the traditional barriers to CNS entry. Some clinical trials in man also suggest nose-to-brain drug delivery, although definitive proof in man is lacking. This review focuses on new nasal delivery technologies designed to overcome inherent anatomical and physiological challenges and facilitate more efficient and targeted drug delivery for CNS disorders.

  7. A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery.

    Directory of Open Access Journals (Sweden)

    Annabelle Ballesta

    2011-09-01

    Full Text Available Circadian timing largely modifies efficacy and toxicity of many anticancer drugs. Recent findings suggest that optimal circadian delivery patterns depend on the patient genetic background. We present here a combined experimental and mathematical approach for the design of chronomodulated administration schedules tailored to the patient molecular profile. As a proof of concept we optimized exposure of Caco-2 colon cancer cells to irinotecan (CPT11, a cytotoxic drug approved for the treatment of colorectal cancer. CPT11 was bioactivated into SN38 and its efflux was mediated by ATP-Binding-Cassette (ABC transporters in Caco-2 cells. After cell synchronization with a serum shock defining Circadian Time (CT 0, circadian rhythms with a period of 26 h 50 (SD 63 min were observed in the mRNA expression of clock genes REV-ERBα, PER2, BMAL1, the drug target topoisomerase 1 (TOP1, the activation enzyme carboxylesterase 2 (CES2, the deactivation enzyme UDP-glucuronosyltransferase 1, polypeptide A1 (UGT1A1, and efflux transporters ABCB1, ABCC1, ABCC2 and ABCG2. DNA-bound TOP1 protein amount in presence of CPT11, a marker of the drug PD, also displayed circadian variations. A mathematical model of CPT11 molecular pharmacokinetics-pharmacodynamics (PK-PD was designed and fitted to experimental data. It predicted that CPT11 bioactivation was the main determinant of CPT11 PD circadian rhythm. We then adopted the therapeutics strategy of maximizing efficacy in non-synchronized cells, considered as cancer cells, under a constraint of maximum toxicity in synchronized cells, representing healthy ones. We considered exposure schemes in the form of an initial concentration of CPT11 given at a particular CT, over a duration ranging from 1 to 27 h. For any dose of CPT11, optimal exposure durations varied from 3h40 to 7h10. Optimal schemes started between CT2h10 and CT2h30, a time interval corresponding to 1h30 to 1h50 before the nadir of CPT11 bioactivation rhythm in

  8. Sizing ERP implementation projects: an activity-based approach

    NARCIS (Netherlands)

    Janssens, G.; Kusters, R.J.; Heemstra, F.J.

    2008-01-01

    ERP implementation projects affect large parts of an implementing organization and lead to changes in the way an organization performs its tasks. The costs needed for the effort to implement these systems are hard to estimate. Research indicates that the size of an ERP project can be a useful

  9. A fuzzy hybrid approach for project manager selection

    Directory of Open Access Journals (Sweden)

    Ahmad Jafarnejad Chaghooshi

    2016-09-01

    Full Text Available Suitable project manager has a significant impact on successful accomplishment of the project. Managers should possess such skills in order to effectively cope with the competition. In this respect, selecting managers based on their skills can lead to a competitive advantage towards the achievement of organizational goals. selection of the suitable project manager can be viewed as a multi-criteria decision making (MCDM problem and an extensive evaluation of criteria, such as Technical skills, experience skills, Personal qualities and the related criteria must be considered in the selection process of project manager. The fuzzy set theory and MCDM methods appears as an essential tools to provide a decision framework that incorporates imprecise judgments and multi criteria nature of project manager selection process inherent in this process. This paper proposes the joint use of the Fuzzy DEMATEL (FDEMATEL and Fuzzy VIKOR methods for the decision-making process of selecting the most suitable managers for projects. First, with the opinions of the senior managers based on project management competency model (ICB-IPMA, all the criteria required for the selection are gathered. Then the FDEMATEL method is used to prioritize the importance of various criteria and FVIKOR used to rank the alternatives in a preferred order to select the best project managers from a number of alternatives. Next, a real case study used to illustrate the process of the proposed method. Finally, some conclusions are discussed at the end of this study.

  10. An Applied Project-Driven Approach to Undergraduate Research Experiences

    Science.gov (United States)

    Karls, Michael A.

    2017-01-01

    In this paper I will outline the process I have developed for conducting applied mathematics research with undergraduates and give some examples of the projects we have worked on. Several of these projects have led to refereed publications that could be used to illustrate topics taught in the undergraduate curriculum.

  11. The Project-Based Learning Approach in Environmental Education

    Science.gov (United States)

    Genc, Murat

    2015-01-01

    The purpose of this study is to investigate the effect of project-based learning on students' attitudes toward the environment. In the study that was performed with 39 students who take the "Environmental Education" course, attitude changes toward the environment were investigated in students who developed projects on environmental…

  12. Systemwide Implementation of Project-Based Learning: The Philadelphia Approach

    Science.gov (United States)

    Schwalm, Jason; Tylek, Karen Smuck

    2012-01-01

    Citywide implementation of project-based learning highlights the benefits--and the challenges--of promoting exemplary practices across an entire out-of-school time (OST) network. In summer 2009, the City of Philadelphia and its intermediary, the Public Health Management Corporation (PHMC), introduced project-based learning to a network of more…

  13. Community health workers and health care delivery: evaluation of a women's reproductive health care project in a developing country.

    Science.gov (United States)

    Wajid, Abdul; White, Franklin; Karim, Mehtab S

    2013-01-01

    As part of the mid-term evaluation of a Women's Health Care Project, a study was conducted to compare the utilization of maternal and neonatal health (MNH) services in two areas with different levels of service in Punjab, Pakistan. A cross-sectional survey was conducted to interview Married Women of Reproductive Age (MWRA). Information was collected on MWRA knowledge regarding danger signs during pregnancy, delivery, postnatal periods, and MNH care seeking behavior. After comparing MNH service utilization, the two areas were compared using a logistic regression model, to identify the association of different factors with the intervention after controlling for socio-demographic, economic factors and distance of the MWRA residence to a health care facility. The demographic characteristics of women in the two areas were similar, although socioeconomic status as indicated by level of education and better household amenities, was higher in the intervention area. Consequently, on univariate analysis, utilization of MNH services: antenatal care, TT vaccination, institutional delivery and use of modern contraceptives were higher in the intervention than control area. Nonetheless, multivariable analysis controlling for confounders such as socioeconomic status revealed that utilization of antenatal care services at health centers and TT vaccination during pregnancy are significantly associated with the intervention. Our findings suggest positive changes in health care seeking behavior of women and families with respect to MNH. Some aspects of care still require attention, such as knowledge about danger signs and neonatal care, especially umbilical cord care. Despite overall success achieved so far in response to the Millennium Development Goals, over the past two decades decreases in maternal mortality are far from the 2015 target. This report identifies some of the key factors to improving MNH and serves as an interim measure of a national and global challenge that remains

  14. Community health workers and health care delivery: evaluation of a women's reproductive health care project in a developing country.

    Directory of Open Access Journals (Sweden)

    Abdul Wajid

    Full Text Available BACKGROUND: As part of the mid-term evaluation of a Women's Health Care Project, a study was conducted to compare the utilization of maternal and neonatal health (MNH services in two areas with different levels of service in Punjab, Pakistan. METHODS: A cross-sectional survey was conducted to interview Married Women of Reproductive Age (MWRA. Information was collected on MWRA knowledge regarding danger signs during pregnancy, delivery, postnatal periods, and MNH care seeking behavior. After comparing MNH service utilization, the two areas were compared using a logistic regression model, to identify the association of different factors with the intervention after controlling for socio-demographic, economic factors and distance of the MWRA residence to a health care facility. RESULTS: The demographic characteristics of women in the two areas were similar, although socioeconomic status as indicated by level of education and better household amenities, was higher in the intervention area. Consequently, on univariate analysis, utilization of MNH services: antenatal care, TT vaccination, institutional delivery and use of modern contraceptives were higher in the intervention than control area. Nonetheless, multivariable analysis controlling for confounders such as socioeconomic status revealed that utilization of antenatal care services at health centers and TT vaccination during pregnancy are significantly associated with the intervention. CONCLUSIONS: Our findings suggest positive changes in health care seeking behavior of women and families with respect to MNH. Some aspects of care still require attention, such as knowledge about danger signs and neonatal care, especially umbilical cord care. Despite overall success achieved so far in response to the Millennium Development Goals, over the past two decades decreases in maternal mortality are far from the 2015 target. This report identifies some of the key factors to improving MNH and serves as an

  15. How to Grow Project Scientists: A Systematic Approach to Developing Project Scientists

    Science.gov (United States)

    Kea, Howard

    2011-01-01

    The Project Manager is one of the key individuals that can determine the success or failure of a project. NASA is fully committed to the training and development of Project Managers across the agency to ensure that highly capable individuals are equipped with the competencies and experience to successfully lead a project. An equally critical position is that of the Project Scientist. The Project Scientist provides the scientific leadership necessary for the scientific success of a project by insuring that the mission meets or exceeds the scientific requirements. Traditionally, NASA Goddard project scientists were appointed and approved by the Center Science Director based on their knowledge, experience, and other qualifications. However the process to obtain the necessary knowledge, skills and abilities was not documented or done in a systematic way. NASA Goddard's current Science Director, Nicholas White saw the need to create a pipeline for developing new projects scientists, and appointed a team to develop a process for training potential project scientists. The team members were Dr. Harley Thronson, Chair, Dr. Howard Kea, Mr. Mark Goldman, DACUM facilitator and the late Dr. Michael VanSteenberg. The DACUM process, an occupational analysis and evaluation system, was used to produce a picture of the project scientist's duties, tasks, knowledge, and skills. The output resulted in a 3-Day introductory course detailing all the required knowledge, skills and abilities a scientist must develop over time to be qualified for selections as a Project Scientist.

  16. Development and delivery of a workshop methodology: planning for biomass power plant projects

    Energy Technology Data Exchange (ETDEWEB)

    Gray, A.J.; Delbridge, P.; Trevorrow, E.; Pile, C.

    2001-07-01

    This report gives details of the approach used to develop a workshop methodology to help planners and stakeholders address key issues that may arise when submitting a planning application for a biomass power plant in the light of the UK government's energy and climate change targets. The results of interviews with stakeholders (central government, regulatory authorities, developers, planners, non-governmental organisations, local community, resident groups) are summarised, and the NIMBY (not in my back yard) syndrome, the lack of trust in the developer, and lack of awareness of the use of biomass are discussed. Details are given of the design and testing of the workshop methodology and the resulting workshop methodology and workbook guide aimed at understanding the stakeholder issues and concerns through stakeholder discussions.

  17. Conflict Approaches of Effective Project Manager in the Upstream Sector of Indonesian Oil & Gas Industry

    Directory of Open Access Journals (Sweden)

    Adhi Cahyono

    2012-10-01

    Full Text Available Conflict can be functional or dysfunctional to the organization’s performance. This study focused on the relationship between conflict approaches implemented by the project manager based on project team member’s perception on the effectiveness of the project manager in managing project’s conflict. Questionnaires were modified from Barker et al. (1988 to measure conflict management approaches and outcomes of managing project conflict. Data were gathered from 57 respondents who worked in the Engineering, Procurement, and Construction (EPC contractors serving the upstream sector of the Oil and Gas industry in Indonesia. By using Pearson correlation, result of this study indicated that project managers were perceived to be effective in managing project conflict when implementing cooperative and confi rmative approaches, but ineffective when combining competitive and avoidance approaches. Further research should investigate correlation between cultural dimensions with conflict approaches and outcomes of managing conflict.

  18. Effects of Contract Delivery Method on the LEED(trademark) Score of U.S. Navy Military Construction Projects (Fiscal Years 2004-2006) (CD-ROM)

    National Research Council Canada - National Science Library

    Carpenter, Deanna S

    2005-01-01

    ...: 1 CD-ROM; 4 3/4 in.; 484 KB. ABSTRACT: This research study focused on determining the effects that the two major contract delivery methods had on the LEED score of projects over the design and construction time horizon...

  19. An optimization approach for communal home meal delivery service : A case study

    NARCIS (Netherlands)

    Bräysy, Olli; Nakari, Pentti; Dullaert, Wout; Neittaanmäki, Pekka

    2009-01-01

    This paper is the first to discuss the communal home meal delivery problem. The problem can be modelled as a multiple travelling salesman problem with time windows, that is closely related to the well-studied vehicle routing problem with time windows. Experimental results are reported for a

  20. The dynamics of the service delivery process : a value-based approach

    NARCIS (Netherlands)

    Ruyter, de J.C.; Wetzels, M.G.M.; Lemmink, J.G.A.M.; Mattsson, J.

    1997-01-01

    Recent research linking service quality and service satisfaction has raised issues which require conceptual and empirical elaboration. Among these are the formation of satisfaction during the service delivery process and the role of customer value. In this article, the focus is on how different

  1. METHOD FOR SELECTION OF PROJECT MANAGEMENT APPROACH BASED ON FUZZY CONCEPTS

    Directory of Open Access Journals (Sweden)

    Igor V. KONONENKO

    2017-03-01

    Full Text Available Literature analysis of works that devoted to research of the selection a project management approach and development of effective methods for this problem solution is given. Mathematical model and method for selection of project management approach with fuzzy concepts of applicability of existing approaches are proposed. The selection is made of such approaches as the PMBOK Guide, the ISO21500 standard, the PRINCE2 methodology, the SWEBOK Guide, agile methodologies Scrum, XP, and Kanban. The number of project parameters which have a great impact on the result of the selection and measure of their impact is determined. Project parameters relate to information about the project, team, communication, critical project risks. They include the number of people involved in the project, the customer's experience with this project team, the project team's experience in this field, the project team's understanding of requirements, adapting ability, initiative, and others. The suggested method is considered on the example of its application for selection a project management approach to software development project.

  2. TARGETED APPROACH TO MANAGING THE FINANCING OF INNOVATIVE PROJECTS

    Directory of Open Access Journals (Sweden)

    G. G. Balayan

    2014-01-01

    Full Text Available The variant of financing the innovative project that allows you to structure any project on the standard stages, regardless of the content of the project. For decision makers, in the management system information is narrowed to a necessary and sufficient by the correct selection of data. The necessity of timely forecast of problem situations and liquidation of not bringing to the state of the problem. It is proposed to organize the state structure, the Bank of innovations, concentrating innovations and connecting inventors with investors and customers.

  3. Project approach in enterprise management in Kazakhstan

    Directory of Open Access Journals (Sweden)

    Berdykulova G. M.

    2016-03-01

    Full Text Available the article is dedicated to study the advanced case of small business of Kazakhstan on reorganization of organizational structure in accord with the methodology of Project Management Body of Knowledge (PMBOK.

  4. [Life project of residents and institutional approach in nursing homes].

    Science.gov (United States)

    Chanut, Corinne

    The life project in a nursing home involves all the players concerned: first of all, the resident, then the caregivers, the families and the institution. This unifying tool, organised around the elderly, helps to develop collective competencies, favours the integration of new residents and reassures families. This article presents a nursing home's experience of setting up a life project. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  5. An Agent Based Approach for Project Management in Construction

    OpenAIRE

    Sencer, Safiye; Turgay, Tahsin

    2013-01-01

    Project management has an important role in terms of time, cost and flexibility. An agentbased architecture provides additional robustness, scalability, flexibility that is particularly appropriate for problems with a dynamic and distributed nature. Integrated agent based project management covers design and construction planning. It is combined with plan execution, tolerating both the design and plan, which may be changed as necessary. In this reason, the decision making process requires tha...

  6. Ultrasound and microbubble-targeted delivery of therapeutic compounds : ICIN Report Project 49: Drug and gene delivery through ultrasound and microbubbles

    NARCIS (Netherlands)

    Juffermans, L J M; Meijering, D B M; van Wamel, A; Henning, R H; Kooiman, K; Emmer, M; de Jong, N; van Gilst, W H; Musters, R; Paulus, W J; van Rossum, A C; Deelman, L E; Kamp, O

    The molecular understanding of diseases has been accelerated in recent years, producing many new potential therapeutic targets. A noninvasive delivery system that can target specific anatomical sites would be a great boost for many therapies, particularly those based on manipulation of gene

  7. The catcher in the why: developing an evidence-based approach to the organization, delivery and evaluation of pre-registration nurse educational programmes.

    Science.gov (United States)

    Warne, T; Holland, K; McAndrew, S

    2011-03-01

    Changes to the pedagogy of pre-registration nurse education and training have become a global phenomenon. However, the evidence base to inform responses to these changes and the impact on nursing practice is limited. This paper explores the outcomes of an innovative approach aimed at ensuring responses to these drivers for change, particularly in curriculum development, the organisation, management and delivery of programmes and the enhancement of the student experience, are evidence based. This paper reports on an organisational change project undertaken in a School of Nursing in the North West of England, UK. The project involved 12 interrelated work streams used to explore aspects of the student journey from recruitment through progression to eventual employment. An evidence base was developed through a methodological bricolage that drew upon a robust and authentic mixture of systematic literature reviews, contemporaneous analysis of educational practice and evaluation of the student experience. This was used to underpin the decision making processes required to promote innovation in programme design, to increase the involvement of students in the facilitation and evaluation of their learning experiences, and helped shape the organisational changes required for embedding an evidenced-based culture in the School. Consistent and transformational leadership has been key to the project's success in communicating and managing the changes. Copyright © 2010 Elsevier Ltd. All rights reserved.

  8. Management of large complex multi-stakeholders projects: a bibliometric approach

    Directory of Open Access Journals (Sweden)

    Aline Sacchi Homrich

    2017-06-01

    Full Text Available The growing global importance of large infrastructure projects has piqued the interest of many researchers in a variety of issues related to the management of large, multi-stakeholder projects, characterized by their high complexity and intense interaction among numerous stake-holders with distinct levels of responsibility. The objective of this study is to provide an overview of the academic literature focused on the management of these kinds of projects, describing the main themes considered, the lines of research identified and prominent trends. Bibliometric analysis techniques were used as well as network and content analysis. Research for information was performed in the scientific database, ISI Web of Knowledge and Scopus. The initial sample analysis consisted of 144 papers published between 1984 and 2014 and expanded to the references cited in these papers. The models identified in the literature converge with the following key-processes: project delivery systems; risk-management models; project cost management; public-private partnership.

  9. Experimentation on accuracy of non functional requirement prioritization approaches for different complexity projects

    OpenAIRE

    Raj Kumar Chopra; Varun Gupta; Durg Singh Chauhan

    2016-01-01

    Non functional requirements must be selected for implementation together with functional requirements to enhance the success of software projects. Three approaches exist for performing the prioritization of non functional requirements using the suitable prioritization technique. This paper performs experimentation on three different complexity versions of the industrial software project using cost-value prioritization technique employing three approaches. Experimentation is conducted to analy...

  10. An approach to establishing cooperative R ampersand D projects with Russian Institutes

    International Nuclear Information System (INIS)

    Hunter, T.; Albert, T.; Fryberger, T.; Romanovsky, V.

    1993-01-01

    An important part of technology exchange between the US and the former Soviet Union is the identification and implementation of cooperative projects that benefit both Russia and the US. The US Department of Energy and its laboratories have established an approach to identify potential technologies that can contribute to solving US environmental problems and to establish projects for enhancing technology development. This approach consists of screening technologies for US applications, conducting small-scale pilot projects with Russian scientists to evaluate the validity of mechanisms for larger projects, helping develop direct communication between US and Russian scientists who are developing these technologies, and implementing major projects in specific technology development areas. A recent example of this approach is the initiation of projects between the Khlopin Radium Institute and DOE through Sandia National Laboratories and SAIC. This effort has resulted in not only enhanced technology for the US but has also provided an example for future cooperative projects

  11. Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38.

    Science.gov (United States)

    Bala, Vaskor; Rao, Shasha; Boyd, Ben J; Prestidge, Clive A

    2013-11-28

    SN38 (7-ethyl-10-hydroxy camptothecin) is a prominent and efficacious anticancer agent. It is poorly soluble in both water and pharmaceutically approved solvents; therefore, the direct formulation of SN38 in solution form is limited. Currently, the water soluble prodrug of SN38, irinotecan (CPT-11), is formulated as a low pH solution and is approved for chemotherapy. However, CPT-11, along with most other water-soluble prodrugs shows unpredictable inter-patient conversion to SN38 in vivo, instability in the physiological environment and variable dose-related toxicities. More recently, macromolecular prodrugs (i.e. EZN-2208, IMMU-130) and nanomedicine formulations (i.e. nanoemulsions, polymeric micelles, lipid nanocapsule/nanoparticle, and liposomes) of SN38 have been investigated for improved delivery to cancer cells and tissues. Specifically, these carriers can take advantage of the EPR effect to direct drug preferentially to tumour tissues, thereby substantially improving efficacy and minimising side effects. Furthermore, oral delivery has been shown to be possible in preclinical results using nanomedicine formulations (i.e. dendrimers, lipid nanocapsules, polymeric micelles). This review summarizes the recent advances for the delivery of SN38 with a focus on macromolecular prodrugs and nanomedicines. © 2013 Elsevier B.V. All rights reserved.

  12. Defining Investment Additionality for CDM projects - practical approaches

    International Nuclear Information System (INIS)

    Greiner, Sandra; Michaelowa, Axel

    2003-01-01

    The environmental integrity of the CDM under the Kyoto Protocol depends on the possibility to avoid giving emission credits to projects that would have happened anyway. Whether and how 'Investment Additionality' of CDM projects has to be determined is currently a part of climate negotiations. We discuss the rationale of companies to invest in projects and analyse possible criteria to determine Investment Additionality from a theoretical point of view. Differences in the type of investment call for the application of different criteria. Although some criteria are better than others, no single criterion can outweigh the others in all respects. We therefore suggest a scheme for additionality testing that aims at matching types of investment and criteria in a sensible way. Criteria are evaluated on the grounds of robustness to manipulation, degree of coverage and appropriateness for testing the investment decision under consideration

  13. Development of Entrepreneurship Competences from Project Based Learning Approaches

    Directory of Open Access Journals (Sweden)

    Lidia SÁNCHEZ GONZÁLEZ

    2017-02-01

    Full Text Available A key issue for any educational institution is to train individuals in such a way that they participate efficiently in their context. The current context where learning is carried out is digital era. With this landscape, and taking into account the current socioeconomic situation, it is necessary to increase students’ employability. This requires that what is taught in educational institutions fits with companies’ requirements. In this sense one of most common companies’ requirement is that students have knowledge about how to develop a project from scratch. In order to address this issue, the present paper poses the application of a project based learning methodology. This methodology is applied in an experiment that comprises two academic years. During each year, the students should develop complete projects working as teams and obtain final products. In this way, it was possible to develop competences that can be interesting for companies and also to increment students’ motivation.

  14. Approaching the Practice Quality Improvement Project in Interventional Radiology.

    Science.gov (United States)

    Reis, Stephen P; White, Benjamin; Sutphin, Patrick D; Pillai, Anil K; Kalva, Sanjeeva P; Toomay, Seth M

    2015-12-01

    An important component of maintenance of certification and quality improvement in radiology is the practice quality improvement (PQI) project. In this article, the authors describe several methodologies for initiating and completing PQI projects. Furthermore, the authors illustrate several tools that are vital in compiling, analyzing, and presenting data in an easily understandable and reproducible manner. Last, they describe two PQI projects performed in an interventional radiology division that have successfully improved the quality of care for patients. Using the DMAIC (define, measure, analyze, improve, control) quality improvement framework, interventional radiology throughput has been increased, to lessen mediport wait times from 43 to 8 days, and mediport infection rates have decreased from more than 2% to less than 0.4%. Copyright © 2015 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  15. An approach to the relationship, environment-project-administration

    International Nuclear Information System (INIS)

    Angel Sanin, Enrique

    1999-01-01

    Interdisciplinary groups working in environmental management, have to deal with three different problems, understanding the regional environment in which the project will be implemented, estimating the environmental impacts and devising the environmental management plan (EMP). These three realities environment, project and management are loosely defined, their limits are not clear and, therefore, several things are mean by the same word. In this article, an attempt to express these three realities in a language with some mathematical rigor is presented, looking for precision in their meaning. Some pertinent conclusions regarding environmental management are derived from the mathematical attempt

  16. The Single And Multi Project Approach To Planning And Scheduling

    DEFF Research Database (Denmark)

    Andersson, Niclas

    2008-01-01

    The fragmentation of the construction industry in Denmark is reflected in the organisation of construction projects, which typically involves a large number of subcontractors. The main contractor, being responsible for the planning and scheduling of construction work, is thus faced with the chall......The fragmentation of the construction industry in Denmark is reflected in the organisation of construction projects, which typically involves a large number of subcontractors. The main contractor, being responsible for the planning and scheduling of construction work, is thus faced...

  17. Learning Approaches - Final Report Sub-Project 4

    DEFF Research Database (Denmark)

    Dirckinck-Holmfeld, Lone; Rodríguez Illera, José Luis; Escofet, Anna

    2007-01-01

    The overall aim of Subproject 4 is to apply learning approaches that are appropriate and applicable using ICT. The task is made up of two components 4.1 dealing with learning approaches (see deliverable 4.1), and component 4.2 application of ICT (see deliverable 4.2, deliverable 4.3 & deliverable...

  18. A Project Management Approach to Applying Best Practices to Online CS/MIS Experiential Learning Projects

    Science.gov (United States)

    Schwieger, Dana; Surendran, Ken

    2015-01-01

    The value of experiential learning projects (which are usually major assessments in courses) in education has been touted since the early 1900s (Dewey, 1938). These projects have the potential to deepen students' understanding of course topics by allowing them to put concepts into practice and watch the results develop. However, experiential…

  19. Implementation of knowledge management approach in project oriented activities. Experience from simulator upgrade project

    International Nuclear Information System (INIS)

    Pironkov, L.

    2010-01-01

    Project specifics: Replacement of analogue process control system with Ovation®based Distributed Control System; Hybrid solution with simulated I&C logic and stimulated Human Machine Interface; Initial design ‐“turn‐key” project based on standard relationship “single customer –single contractor

  20. Project INTEGRATE - a common methodological approach to understand integrated health care in Europe

    Directory of Open Access Journals (Sweden)

    Lucinda Cash-Gibson

    2014-12-01

    Full Text Available Background: The use of case studies in health services research has proven to be an excellent methodology for gaining in-depth understanding of the organisation and delivery of health care. This is particularly relevant when looking at the complexity of integrated healthcare programmes, where multifaceted interactions occur at the different levels of care and often without a clear link between the interventions (new and/or existing and their impact on outcomes (in terms of patients health, both patient and professional satisfaction and cost-effectiveness. Still, integrated care is seen as a core strategy in the sustainability of health and care provision in most societies in Europe and beyond. More specifically, at present, there is neither clear evidence on transferable factors of integrated care success nor a method for determining how to establish these specific success factors. The drawback of case methodology in this case, however, is that the in-depth results or lessons generated are usually highly context-specific and thus brings the challenge of transferability of findings to other settings, as different health care systems and different indications are often not comparable. Project INTEGRATE, a European Commission-funded project, has been designed to overcome these problems; it looks into four chronic conditions in different European settings, under a common methodology framework (taking a mixed-methods approach to try to overcome the issue of context specificity and limited transferability. The common methodological framework described in this paper seeks to bring together the different case study findings in a way that key lessons may be derived and transferred between countries, contexts and patient-groups, where integrated care is delivered in order to provide insight into generalisability and build on existing evidence in this field.Methodology: To compare the different integrated care experiences, a mixed-methods approach has

  1. The Company Approach to Software Engineering Project Courses

    Science.gov (United States)

    Broman, D.; Sandahl, K.; Abu Baker, M.

    2012-01-01

    Teaching larger software engineering project courses at the end of a computing curriculum is a way for students to learn some aspects of real-world jobs in industry. Such courses, often referred to as capstone courses, are effective for learning how to apply the skills they have acquired in, for example, design, test, and configuration management.…

  2. A systems engineering approach for realizing sustainability in infrastructure projects

    Directory of Open Access Journals (Sweden)

    Mohamed Matar

    2017-08-01

    The developed model addresses an identified gap within the current body of knowledge by considering infrastructure projects. Through the ability to simulate different scenarios, the model enables identifying which activities, products, and processes impact the environment more, and hence potential areas for optimization and improvement.

  3. A Coordinated Decentralized Approach to Online Project Development

    Science.gov (United States)

    Mykota, David

    2013-01-01

    With the growth rate of online learning outpacing traditional face-to-face instruction, universities are beginning to recognize the importance of strategic planning in its development. Making the case for online learning requires sound project management practices and an understanding of the business models on which it is predicated. The objective…

  4. AN APPROACH TO THE QUALITY IMPROVEMENT OF A MASSIVE INVESTMENT PROJECT BY INTEGRATING ICT AND QMS

    Directory of Open Access Journals (Sweden)

    Tamara Gvozdenovic

    2007-12-01

    Full Text Available This work has presented an approach to the quality improvement of an investment project by the change in the concept of project management. Building time of the investment project is a complex factor which needs a special attention. It is well known that the PERT method has been applied with long-lasting investment projects, where a big time distance brings about significant uncertainty of future situations. Microsoft Project 2002 and Matlab: Neural Network Toolbox are the software tools used for solving the problem of investment project management.

  5. Solving multi-customer FPR model with quality assurance and discontinuous deliveries using a two-phase algebraic approach.

    Science.gov (United States)

    Chiu, Yuan-Shyi Peter; Chou, Chung-Li; Chang, Huei-Hsin; Chiu, Singa Wang

    2016-01-01

    A multi-customer finite production rate (FPR) model with quality assurance and discontinuous delivery policy was investigated in a recent paper (Chiu et al. in J Appl Res Technol 12(1):5-13, 2014) using differential calculus approach. This study employs mathematical modeling along with a two-phase algebraic method to resolve such a specific multi-customer FPR model. As a result, the optimal replenishment lot size and number of shipments can be derived without using the differential calculus. Such a straightforward method may assist practitioners who with insufficient knowledge of calculus in learning and managing the real multi-customer FPR systems more effectively.

  6. An experimental design approach to the preparation of pegylated polylactide-co-glicolide gentamicin loaded microparticles for local antibiotic delivery

    Energy Technology Data Exchange (ETDEWEB)

    Dorati, Rossella; DeTrizio, Antonella; Genta, Ida; Grisoli, Pietro; Merelli, Alessia [Department of Drug Sciences, Viale Taramelli 12, University of Pavia, 27100, Pavia (Italy); Tomasi, Corrado [IENI CNR Lecco Unit, Via Promessi Sposi 29, 23900, Lecco (Italy); Conti, Bice, E-mail: bice.conti@unipv.it [Department of Drug Sciences, Viale Taramelli 12, University of Pavia, 27100, Pavia (Italy)

    2016-01-01

    The present paper takes into account the DOE application to the preparation process of biodegradable microspheres for osteomyelitis local therapy. With this goal gentamicin loaded polylactide-co-glycolide-co-polyethyleneglycol (PLGA-PEG) microspheres were prepared and investigated. Two preparation protocols (o/w and w/o/w) with different process conditions, and three PLGA-PEG block copolymers with different compositions of lactic and glycolic acids and PEG, were tested. A Design Of Experiment (DOE) screening design was applied as an approach to scale up manufacturing step. The results of DOE screening design confirmed that w/o/w technique, the presence of salt and the 15%w/v polymer concentration positively affected the EE% (72.1–97.5%), and span values of particle size distribution (1.03–1.23), while salt addition alone negatively affected the yield process. Process scale up resulted in a decrease of gentamicin EE% that can be attributed to the high volume of water used to remove PVA and NaCl residues. The results of in vitro gentamicin release study show prolonged gentamicin release up to three months from the microspheres prepared with salt addition in the dispersing phase; the behavior being consistent with their highly compact structure highlighted by scanning electron microscopy analysis. The prolonged release of gentamicin is maintained even after embedding the biodegradable microspheres into a thermosetting composite gel made of chitosan and acellular bovine bone matrix (Orthoss® granules), and the microbiologic evaluation demonstrated the efficacy of the gentamicin loaded microspheres on Escherichia coli. The collected results confirm the feasibility of the scale up of microsphere manufacturing process and the high potential of the microparticulate drug delivery system to be used for the local antibiotic delivery to bone. - Highlights: • To get a more effective therapy for the prevention and treatment of osteomyelitis. • To exploit the local

  7. A pragmatic approach to monitor and evaluate implementation and impact of differentiated ART delivery for global and national stakeholders.

    Science.gov (United States)

    Ehrenkranz, Peter D; Calleja, Jesus Mg; El-Sadr, Wafaa; Fakoya, Ade O; Ford, Nathan; Grimsrud, Anna; Harris, Kate L; Jed, Suzanne L; Low-Beer, Daniel; Patel, Sadhna V; Rabkin, Miriam; Reidy, William John; Reinisch, Annette; Siberry, George K; Tally, Leigh A; Zulu, Isaac; Zaidi, Irum

    2018-03-01

    The World Health Organization's (WHO) recommendation of "Treat All" has accelerated the call for differentiated antiretroviral therapy (ART) delivery, a method of care that efficiently uses limited resources to increase access to HIV treatment. WHO has further recommended that stable individuals on ART receive refills every 3 to 6 months and attend clinical visits every 3 to 6 months. However, there is not yet consensus on how to ensure that the quality of services is maintained as countries strive to meet these standards. This commentary responds to this gap by defining a pragmatic approach to the monitoring and evaluation (M&E) of the scale up of differentiated ART delivery for global and national stakeholders. Programme managers need to demonstrate that the scale up of differentiated ART delivery is achieving the desired effectiveness and efficiency outcomes to justify continued support by national and global stakeholders. To achieve this goal, the two existing global WHO HIV treatment indicators of ART retention and viral suppression should be augmented with two broad aggregate measures. The addition of indicators measuring the frequency of (1) clinical and (2) refill visits by PLHIV per year will allow evaluation of the pace of scale up while monitoring its overall effect on the quality and efficiency of services. The combination of these four routinely collected aggregate indicators will also facilitate the comparison of outcomes among facilities, regions or countries implementing different models of ART delivery. Enhanced monitoring or additional assessments will be required to answer other critical questions on the process of implementation, acceptability, effectiveness and efficiency. These proposed outcomes are useful markers for the effectiveness and efficiency of the health system's attempts to deliver quality treatment to those who need it-and still reserve as much of the available resource pool as possible for other key elements of the HIV response

  8. Two Approaches to Workplace Flexible Delivery and Assessment in a Rural Community.

    Science.gov (United States)

    Evans, Terry D.

    2001-01-01

    Two approaches to flexible learning were tried in an Australian college of technical and further education: in engineering, the industry enterprise approach focused on employers as clients; in office administration, the individual customization approach viewed the student as client. Each model fit different types of training needs and contexts.…

  9. The DIMBI project – innovative approaches for teaching business informatics

    Directory of Open Access Journals (Sweden)

    Ivan Kuyumdzhiev

    2016-11-01

    Full Text Available The purpose of this article is to collect and analyze data on existing methods of teaching business informatics in leading Bulgarian universities and suggest areas for improvements. Based on a collected data guidelines for innovative teaching methods in the field of BI and DW are developed. Proposed methods are divided in several sections – lectures, exercises (groups’ size, tools used, software, hardware, teaching methods, and real life customers, students’ projects, control methods. The findings of conducted feasibility study show that the business, students and universities need an innovative methodology of teaching business informatics and properly implemented this methodology has a high probability of success. This paper is written within the Erasmus plus KA2 project “Developing the innovative methodology of teaching business informatics” (DIMBI, 2015-1-PL01-KA203-0016636.

  10. An approach to knowledge management for EUROSAFE projects

    International Nuclear Information System (INIS)

    Goldschmidt, F.; Gelder, P. De; Beraha, D.

    2005-01-01

    The objective of a knowledge management system (KMS) in the field of Nuclear Safety Assessment is to keep competence in expertise and research at the best level. This contribution proposes a diagram of KM organization associated with the Eurosafe Safety Assessment Guide project proposal. The aim of the KM action is to test and bring forward a generic and perennial method of knowledge management adapted to the safety culture. It will be interested to support the access to information useful for the practices of expertise by organizing a knowledge mapping, supporting the exchanges of know-how by the consolidation of a competence network and the externalization of expert knowledge. This article presents the actions in progress at AVN, GRS and IRSN, and suggests some principles based on experience feedbacks drawn from the literature. It is not supposed to be exhaustive but rather to encourage other Technical Support Organizations to take part in this KM action associated with the technical project. We suggest to organize the KM action in three phases: (1) definition of a KM Strategy adapted to the technical project; (2) implementation of KM selected actions (actors sensitization, tests of KM methods, etc); (3) choice and fulfillment of effective and perennial KM solutions. (authors)

  11. Needs assessment in health research projects: a new approach to project management in iran.

    Science.gov (United States)

    Peykari, Niloofar; Owlia, Parviz; Malekafzali, Hossein; Ghanei, Mostafa; Babamahmoodi, Abdolreza; Djalalinia, Shirin

    2013-01-01

    The science and technology health plan has defined the outline of health research to the national vision of Iran by 2025. The aim of this study was to focus on the process of needs assessment of health research projects also health research priority setting in Iran. THE PROJECT MANAGEMENT LIFE CYCLE HAS FOUR PHASES: Initiation, Planning, Execution and Closure. Based on abovementioned points we conducted the study. Focusing on the needs assessment led to systematic implementation of needs assessment of health project in all of the medical sciences universities. Parallel with this achieved strategies health research priority setting was followed through specific process from empowerment to implementation. We should adopt with more systematic progressive methods of health project managements for both our national convenience as well as our international health research programs.

  12. Operational challenges in conducting a community-based technology-enabled mental health services delivery model for rural India: Experiences from the SMART Mental Health Project.

    Science.gov (United States)

    Maulik, Pallab K; Kallakuri, Sudha; Devarapalli, Siddhardha

    2018-01-01

    Background: There are large gaps in the delivery of mental health care in low- and middle-income countries such as India, and the problems are even more acute in rural settings due to lack of resources, remoteness, and lack of infrastructure, amongst other factors. The Systematic Medical Appraisal Referral and Treatment (SMART) Mental Health Project was conceived as a mental health services delivery model using technology-based solutions for rural India. This paper reports on the operational strategies used to facilitate the implementation of the intervention. Method: Key components of the SMART Mental Health Project included delivering an anti-stigma campaign, training of primary health workers in screening, diagnosing and managing stress, depression and increased suicide risk and task sharing of responsibilities in delivering care; and using mobile technology based electronic decision support systems to support delivery of algorithm based care for such disorders. The intervention was conducted in 42 villages across two sites in the state of Andhra Pradesh in south India. A pre-post mixed methods evaluation was done, and in this paper operational challenges are reported. Results: Both quantitative and qualitative results from the evaluation from one site covering about 5000 adults showed that the intervention was feasible and acceptable, and initial results indicated that it was beneficial in increasing access to mental health care and reducing depression and anxiety symptoms. A number of strategies were initiated in response to operational challenges to ensure smoother conduct of the project and facilitated the project to be delivered as envisaged. Conclusions: The operational strategies initiated for this project were successful in ensuring the delivery of the intervention. Those, coupled with other more systematic processes have informed the researchers to understand key processes that need to be in place to develop a more robust study, that could eventually be

  13. Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design.

    Science.gov (United States)

    Isailović, Tanja; Ðorđević, Sanela; Marković, Bojan; Ranđelović, Danijela; Cekić, Nebojša; Lukić, Milica; Pantelić, Ivana; Daniels, Rolf; Savić, Snežana

    2016-01-01

    We aimed to develop lecithin-based nanoemulsions intended for effective aceclofenac (ACF) skin delivery utilizing sucrose esters [sucrose palmitate (SP) and sucrose stearate (SS)] as additional stabilizers and penetration enhancers. To find the suitable surfactant mixtures and levels of process variables (homogenization pressure and number of cycles - high pressure homogenization manufacturing method) that result in drug-loaded nanoemulsions with minimal droplet size and narrow size distribution, a combined mixture-process experimental design was employed. Based on optimization data, selected nanoemulsions were evaluated regarding morphology, surface charge, drug-excipient interactions, physical stability, and in vivo skin performances (skin penetration and irritation potential). The predicted physicochemical properties and storage stability were proved satisfying for ACF-loaded nanoemulsions containing 2% of SP in the blend with 0%-1% of SS and 1%-2% of egg lecithin (produced at 50°C/20 cycles/800 bar). Additionally, the in vivo tape stripping demonstrated superior ACF skin absorption from these nanoemulsions, particularly from those containing 2% of SP, 0.5% of SS, and 1.5% of egg lecithin, when comparing with the sample costabilized by conventional surfactant - polysorbate 80. In summary, the combined mixture-process experimental design was shown as a feasible tool for formulation development of multisurfactant-based nanosized delivery systems with potentially improved overall product performances.

  14. A Constrained and Guided Approach for Managing Software Engineering Course Projects

    Science.gov (United States)

    Cheng, Y.-P.; Lin, J. M.-C.

    2010-01-01

    This paper documents several years of experimentation with a new approach to organizing and managing projects in a software engineering course. The initial failure and subsequent refinements that the new approach has been through since 2004 are described herein. The "constrained and guided" approach, as it is called, has helped to reduce…

  15. Switches for multiple behavioral states and a viral-based approach to non-invasive whole-brain cargo delivery (Conference Presentation)

    Science.gov (United States)

    Gradinaru, Viviana

    2017-05-01

    Over the past years we have worked on: (1) Viral-based approaches to non-invasive whole-brain cargo delivery: Genetically-encoded tools that can be used to visualize, monitor, and modulate mammalian neurons are revolutionizing neuroscience. These tools are particularly powerful in rodents and invertebrate models where intersectional transgenic strategies are available to restrict their expression to defined cell populations. However, use of genetic tools in non-transgenic animals is often hindered by the lack of vectors capable of safe, efficient, and specific delivery to the desired cellular targets. To begin to address these challenges, we have developed an in vivo Cre-based selection platform (CREATE) for identifying adeno-associated viruses (AAVs) that more efficiently transduce genetically defined cell populations. Our platform's novelty and power arises from the additional selective pressure imparted by a recovery step that amplifies only those capsid variants that have functionally transduced a genetically-defined, Cre-expressing target cell population. The Cre-dependent capsid recovery works within heterogeneous tissue samples without the need for additional steps such as selective capsid recovery approaches that require cell sorting or secondary adenovirus infection. As a first test of the CREATE platform, we selected for viruses that transduced the brain after intravascular delivery and found a novel vector, AAV-PHP.B, that is 40- to 90-fold more efficient at transducing the brain than the current standard, AAV9. AAV-PHP.B transduces most neuronal types and glia across the brain. We also demonstrate here how whole-body tissue clearing can facilitate transduction maps of systemically delivered genes. Since CNS disorders are notoriously challenging due to the restrictive nature of the blood brain barrier our discovery that recombinant vectors can be engineered to overcome this barrier is enabling for the whole field. With the exciting advances in gene

  16. Open Learning Approach with Remote Experiments: OLAREX Project

    Directory of Open Access Journals (Sweden)

    Javier Garcia-Zubia

    2013-10-01

    Full Text Available The project’s primary target groups are the European secondary schools. More specifically: secondary school and university teachers, students and managers of schools, museum employees and their visitors, and other STEM education providers. The main goal of the OLAREX project is to offer the providers of formal and non-formal education an efficient way to improve their e-didactic and digital competences. For this purpose a training program is created with using ICT-based learning materials, remote laboratories, and e-learning methodologies

  17. Individual Learning in Construction Projects: Professions and their Approaches

    Directory of Open Access Journals (Sweden)

    Ingeborg Wasif

    2010-10-01

    Full Text Available New materials, use of sophisticated technologies and increased customer demands, in combination with growing competition among construction companies, have led to a high organizational boundaries. The results indicate that personal networks are the most common source of learning for all professions. While clients, architects, and designers also engage in reading and attending courses, site managers and workers are less engaged in these activities. Experimenting and organizing for learning appear to be underutilized strategies by all professions. This leads to the conclusion that attempts to increase learning have to address the differences in learning behaviours of the various groups. Further, focus on experimenting and organizing for learning is a possibility to change the learning behaviour from learning as a consequence of problems to learning for future improvement.degree of specialization. For successful integration of the different professional specialists, there is a need for shared learning between project co-workers. Based on twenty eight interviews in six different Swedish construction projects, this paper illustrates strategies for individual and shared learning, among different actors and across various

  18. The Hanford Environmental Dose Reconstruction (HEDR) Project: Technical approach

    International Nuclear Information System (INIS)

    Napier, B.A.; Freshley, M.D.; Gilbert, R.O.; Haerer, H.A.; Morgan, L.G.; Rhoads, R.E.; Woodruff, R.K.

    1990-01-01

    Historical measurements and current assessment techniques are being combined to estimate potential radiation doses to people from radioactive releases to the air, the Columbia River, soils, and ground water at the Hanford Site since 1944. Environmental contamination from these releases has been monitored, at varying levels of detail, for 45 yr. Phase I of the Hanford Environmental Reconstruction Project will estimate the magnitude of potential doses, their areal extends, and their associated uncertainties. The Phase I study area comprises 10 counties in eastern Washington and northern Oregon, within a 100-mi radius of the site, including a stretch of the Columbia River that was most significantly affected. These counties contain a range of projected and measured contaminant levels, environmental exposure pathways, and population groups. Phase I dose estimates are being developed for the periods 1944 through 1947 for air pathways and 1964 through 1966 for river pathways. Important radionuclide/pathway combinations include fission products, such as 131 I, in milk for early atmospheric releases and activation products, such as 32 P and 65 Zn, in fish for releases to the river. Potential doses range over several orders of magnitude within the study area. We will expand the time periods and study are in three successive phases, as warranted by results of Phase I

  19. A nanomedicine-promising approach to provide an appropriate colon-targeted drug delivery system for 5-fluorouracil

    Directory of Open Access Journals (Sweden)

    Singh S

    2015-11-01

    Full Text Available Sima Singh,1,* Niranjan G Kotla,2,* Sonia Tomar,3 Balaji Maddiboyina,4 Thomas J Webster,5,6 Dinesh Sharma,7 Omprakash Sunnapu2 1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 2Technologies for the Advancement of Science, Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, Karnataka, 3Department of Pharmaceutics, Ram Gopal College of Pharmacy, Rohtak, Haryana, 4Department of Pharmaceutics, Maharishi Markandeshwar University, Mullana, Ambala, Haryana, India; 5Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 6Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia; 7Ranbaxy Laboratory Ltd, Gurgaon, Haryana, India *These authors contributed equally to this work Abstract: Targeted drug delivery plays a significant role in disease treatment associated with the colon, affording therapeutic responses for a prolonged period of time with low side effects. Colorectal cancer is the third most common cancer in both men and women with an estimated 102,480 cases of colon cancer and 40,340 cases of rectal cancer in 2013 as reported by the American Cancer Society. In the present investigation, we developed an improved oral delivery system for existing anticancer drugs meant for colon cancer via prebiotic and probiotic approaches. The system comprises three components, namely, nanoparticles of drug coated with natural materials such as guar gum, xanthan gum (that serve as prebiotics, and probiotics. The natural gums play a dual role of protecting the drug in the gastric as well as intestinal conditions to allow its release only in the colon. In vitro results obtained from these experiments indicated the successful targeted delivery of 5-fluorouracil to the colon. Electron microscopy results demonstrated that the prepared nanoparticles were spherical in shape and 200 nm in size. The in vitro release data

  20. Halloysite nanotubes-polymeric nanocomposites: characteristics, modifications and controlled drug delivery approaches

    Directory of Open Access Journals (Sweden)

    P. C. Ferrari

    Full Text Available Abstract Halloysite nanotubes (HNTs are aluminosilicate nanoclay mineral which have a hollow tubular structure and occurs naturally. They are biocompatible and viable carrier for inclusion of biologically active molecules due to the empty space inside the tubular structure. In this article, the HNTs main characteristics, and the HNTs-polymeric nanocomposite formation and their potential application as improvement of the mechanical performance of polymers and entrapment of hydrophilic and lipophilic substances are summarized. Recent works covering the increment of HNTs-polymeric nanocomposites and presenting promising employment of these systems as nanosized carrier, being suitable for pharmaceutical and biomedical applications, based on earlier evidence in literature of its nature to sustain the release of loaded drugs, presenting low cytotoxicity, and providing evidence for controlled drug delivery are reviewed.

  1. Project Management Approach to Transition of the Miamisburg Closure Project From Environmental Cleanup to Post-Closure Operations

    International Nuclear Information System (INIS)

    Carpenter, C.P.; Marks, M.L.; Smiley, S.L.; Gallaher, D.M.; Williams, K.D.

    2006-01-01

    The U.S. Department of Energy (DOE) used a project management approach to transition the Miamisburg Closure Project from cleanup by the Office of Environmental Management (EM) to post-closure operations by the Office of Legacy Management (LM). Two primary DOE orders were used to guide the site transition: DOE Order 430.1B, Real Property Asset Management, for assessment and disposition of real property assets and DOE Order 413.3, Program and Project Management for Acquisition of Capital Assets, for project closeout of environmental cleanup activities and project transition of post-closure activities. To effectively manage these multiple policy requirements, DOE chose to manage the Miamisburg Closure Project as a project under a cross-member transitional team using representatives from four principal organizations: DOE-LM, the LM contractor S.M. Stoller Corporation, DOE-EM, and the EM contractor CH2M Hill Mound Inc. The mission of LM is to manage the Department's post-transition responsibilities and long-term care of legacy liabilities and to ensure the future protection of human health and the environment for cleanup sites after the EM has completed its cleanup activities. (authors)

  2. A mechanics approach to the study of pressure sensitive adhesives and human skin for transdermal drug delivery applications

    Science.gov (United States)

    Taub, Marc Barry

    Transdermal drug delivery is an alternative approach to the systemic delivery of pharmaceuticals where drugs are administered through the skin and absorbed percutaneously. This method of delivery offers several advantages over more traditional routes; most notably, the avoidance of the fast-pass metabolism of the liver and gut, the ability to offer controlled release rates, and the possibility for novel devices. Pressure sensitive adhesives (PSAs) are used to bond transdermal drug delivery devices to the skin because of their good initial and long-term adhesion, clean removability, and skin and drug compatibility. However, an understanding of the mechanics of adhesion to the dermal layer, together with quantitative and reproducible test methods for measuring adhesion, have been lacking. This study utilizes a mechanics-based approach to quantify the interfacial adhesion of PSAs bonded to selected substrates, including human dermal tissue. The delamination of PSA layers is associated with cavitation in the PSA followed by the formation of an extensive cohesive zone behind the debond tip. A quantitative metrology was developed to assess the adhesion and delamination of PSAs, such that it could be possible to easily distinguish between the adhesive characteristics of different PSA compositions and to provide a quantitative basis from which the reliability of adhesive layers bonded to substrates could be studied. A mechanics-based model was also developed to predict debonding in terms of the relevant energy dissipation mechanisms active during this process. As failure of transdermal devices may occur cohesively within the PSA layer, adhesively at the interface between the PSA and the skin, or cohesively between the corneocytes that comprise the outermost layer of the skin, it was also necessary to explore the mechanical and fracture properties of human skin. The out-of-plane delamination of corneocytes was studied by determining the strain energy release rate during

  3. Financing offshore projects: The banker's approach to risk

    International Nuclear Information System (INIS)

    Beldam, R.A.

    1994-01-01

    The author has attempted to consider why companies chose to share risks with banks and looked in particular at the unique risk sharing aspect of project financing and how this may be reflected in the loan documentation. He also has considered the current market place and examined some trends for the future. The future challenge in the North Sea is going to be to use existing and new technology to reduce capital and operating costs, balanced with optimal recovery and safety. From a bank perspective, this type of work is extremely satisfying, if challenging, and the author has no doubt banks will continue to play their part in the future of offshore development wherever it occurs around the world

  4. Energy consumption projection of Nepal: An econometric approach

    DEFF Research Database (Denmark)

    Parajuli, Ranjan; Østergaard, Poul A.; Dalgaard, Tommy

    2014-01-01

    In energy dependent economies, energy consumption is often linked with the growth in Gross Domestic Product (GDP). Energy intensity, defined herewith, as the ratio of the total primary energy consumption (TPE) to the GDP, is a useful concept for understanding the relation between energy demand...... and economic development. The scope of this article is to assess the future primary energy consumption of Nepal, and the projection is carried out along with the formulation of simple linear logarithmic energy consumption models. This initiates with a hypothesis that energy consumption is dependent...... with the national macro-economic parameters. To test the hypothesis, nexus between energy consumption and possible determinant variables are examined. Status of energy consumption between the period of 1996 and 2009, and for the same period, growth of economic parameters are assessed. Three scenarios are developed...

  5. The snake geothermal drilling project. Innovative approaches to geothermal exploration

    Energy Technology Data Exchange (ETDEWEB)

    Shervais, John W. [Utah State Univ., Logan, UT (United States); Evans, James P. [Utah State Univ., Logan, UT (United States); Liberty, Lee M. [Boise State Univ., ID (United States); Schmitt, Douglas R. [University of Alberta, Canada; Blackwell, David D. [Southern Methodist Univ., Dallas, TX (United States)

    2014-02-21

    The goal of our project was to test innovative technologies using existing and new data, and to ground-truth these technologies using slim-hole core technology. The slim-hole core allowed us to understand subsurface stratigraphy and alteration in detail, and to correlate lithologies observed in core with surface based geophysical studies. Compiled data included geologic maps, volcanic vent distribution, structural maps, existing well logs and temperature gradient logs, groundwater temperatures, and geophysical surveys (resistivity, magnetics, gravity). New data included high-resolution gravity and magnetic surveys, high-resolution seismic surveys, three slimhole test wells, borehole wireline logs, lithology logs, water chemistry, alteration mineralogy, fracture distribution, and new thermal gradient measurements.

  6. INEL Waste and Environmental Information Integration Project approach and concepts

    International Nuclear Information System (INIS)

    Dean, L.A.; Fairbourn, P.J.; Randall, V.C.; Riedesel, A.M.

    1994-06-01

    The Idaho National Engineering, Laboratory (INEL) Waste and Environmental Information integration Project (IWEIIP) was established in December 1993 to address issues related to INEL waste and environmental information including: Data quality; Data redundancy; Data accessibility; Data integration. This effort includes existing information, new development, and acquisition activities. Existing information may not be a database record; it may be an entire document (electronic, scanned, or hard-copy), a video clip, or a file cabinet of information. The IWEIIP will implement an effective integrated information framework to manage INEL waste and environmental information as an asset. This will improve data quality, resolve data redundancy, and increase data accessibility; therefore, providing more effective utilization of the dollars spent on waste and environmental information

  7. A project management approach to an ACPE accreditation self-study.

    Science.gov (United States)

    Dominelli, Angela; Iwanowicz, Susan L; Bailie, George R; Clarke, David W; McGraw, Patrick S

    2007-04-15

    In preparation for an on-site evaluation and accreditation by the American Council on Pharmaceutical Education (ACPE), the Albany College of Pharmacy employed project management techniques to complete a comprehensive self-study. A project lifecycle approach, including planning, production, and turnover phases, was used by the project's Self-Study Steering Committee. This approach, with minimal disruption to college operations, resulted in the completion of the self-study process on schedule. Throughout the project, the Steering Committee maintained a log of functions that either were executed successfully or in hindsight, could have been improved. To assess the effectiveness of the project management approach to the the self-study process, feedback was obtained from the College community through a poststudy survey. This feedback, coupled with the Steering Committee's data on possible improvements, form the basis for the lessons learned during this self-study process.

  8. Selection and approbation of new technical approaches in innovation projects

    International Nuclear Information System (INIS)

    Matvienko, V.A.; Pastushenko, V.N.; Zvorykin, K.O.; Zvorykin, L.O.

    1999-01-01

    Large-scale technical approaches based on the application of new technologies, equipment, tools and other production equipping means (PEM) are to be previously tested by technical and engineering practice and thoroughly approved. These circumstances create objective prerequisites for organization within the infrastructure of the 'OU' of a special sector to solve such a problem. A structure-and-logic model of the infrastructure sector is represented. Principal trends of activities of the proposed new sector of the 'OU' infrastructure may become the following ones: personnel training, skill rising and attestation; adaptation of new samples of universal and auxiliary equipment; new technologies and equipment approbation; approbation of actions in nonstandard situations

  9. Uranium Mill Tailings Remedial Action Project: technical approach document

    International Nuclear Information System (INIS)

    1986-05-01

    The Uranium Mill Tailings Radiation Control Act of 1978, PL95-604, grants the Secretary of Energy authority and responsibility to perform such actions as are necessary to minimize radiation health hazards and other environmental hazards from inactive uranium mill sites. These cleanup actions are to be performed in compliance with the EPA standards (40 CFR Part 192) which became final on March 7, 1983. This document describes the general technical approaches and design criteria that are adopted by the US Department of Energy (DOE) in order to implement Remedial Action Plans (RAPs) and final designs that comply with EPA standards

  10. Negotiation processes in urban redevelopment projects: dealing with conflicts by balancing integrative and distributive approaches

    NARCIS (Netherlands)

    Baarveld, Marlijn; Smit, Marnix; Dewulf, Geert P.M.R.

    2015-01-01

    Dealing with conflict through dialogue receives considerable attention in current planning approaches. However, debate and negotiation are also inevitable features in the planning of urban redevelopment projects. Insight into the negotiation process contributes to current planning practice as

  11. A "one health" approach to address emerging zoonoses: the HALI project in Tanzania.

    OpenAIRE

    Jonna A K Mazet; Deana L Clifford; Peter B Coppolillo; Anil B Deolalikar; Jon D Erickson; Rudovick R Kazwala

    2009-01-01

    Jonna Mazet and colleagues describe their work in the Tanzania-based HALI Project, which adopts the ?One Health? approach to address emerging zoonoses and that recognizes the interconnectedness of human, animal, and environmental health.

  12. Rubbertown Next Generation Emission Measurement Demonstration Project Provides Innovative Approaches to Protecting Air Quality

    Science.gov (United States)

    EPA and the Louisville Metro Air Pollution Control District (LMAPCD) are working together on a research project to demonstrate NGEM approaches near facilities in the Rubbertown industrial area of Louisville, KY.

  13. Constrained bayesian inference of project performance models

    OpenAIRE

    Sunmola, Funlade

    2013-01-01

    Project performance models play an important role in the management of project success. When used for monitoring projects, they can offer predictive ability such as indications of possible delivery problems. Approaches for monitoring project performance relies on available project information including restrictions imposed on the project, particularly the constraints of cost, quality, scope and time. We study in this paper a Bayesian inference methodology for project performance modelling in ...

  14. ALARA approach on Qinshan unit I lower internals recovery project

    International Nuclear Information System (INIS)

    Wu Meijing; Xu Hongming; Jiang Jianqi; Chen Zhongyu

    2000-01-01

    Qinshan unit-1 is a 300 Mwe prototype PWR. It has been successfully operating for 4 fuel cycles about 10 years. Some loose parts by the failure of the guide tube of the reactor core neutron flux measurement thimble were observed on the lower structure of Core Barrel during periodical inspection after unloading all fuel assemblies. Qinshan Nuclear Power Company selected Westinghouse Electric Company as contractor to perform the reactor core barrel recovery service after negotiated with 4 world big company. QNPC and Westinghouse worked together to approach the ALARA by increasing water shielding, adding additional steel shielding, fuel pool cleaning and using the long hand tools, remote camera system. The training, mock-up exercise, good personal behavior was greatly contributed to the ALARA approaching. The collective dose and personal exposure of this job were successful controlled by implementing the preset ALARA program. The job was done by the cost of 70 man.mSv collective dose and 3.5 mSv maximum personal exposure despite of the high dose-rate which hot spot in some place is up to several hundred Sv per hour. (author)

  15. Conceptualizing the cross-cultural gaps in managing international aid: HIV/AIDS and TB project delivery in Southern Africa.

    Science.gov (United States)

    Jackson, Terence

    2011-01-01

    There appears to be a gap between the billions of dollars inputted into fighting HIV/AIDS and TB and outcomes. This in part can be attributed to the lack of attention in International Development to managing programmes and projects within complex levels of cross-cultural interactions. International Development often ignores management issues, yet Management Studies is left wanting through a lack of engagement with development issues including the fight against disease and poverty. This paper attempts to link these two disciplines towards mutual benefit, through a critical cross-cultural approach. It provides contextualization of international development policies/strategies; conceptualization of dominant paradigms; structural analysis of how a programme/project fits into the global governance structure; analysis of complexities and levels of cross-cultural interaction and their consequences and the process and implications of knowledge transfer across cultural distances. It concludes with implications for policy and practice, as well as what is needed from cross-disciplinary research. This includes how feedback loops can be strengthened from local to global, how indigenous knowledge may be better understood and integrated, how power relations within the global governance structure could be managed, how cross-cultural interaction could be better understood, and how knowledge transfer/sharing should be critically managed. Copyright © 2010 John Wiley & Sons, Ltd.

  16. The art of 'doing' sustainable agricultural innovation: approaches and attitudes to facilitating transitional projects

    OpenAIRE

    Loeber, A.; Vermeulen, T.; Barbier, M.; Elzen, B.

    2012-01-01

    The management of projects for sustainable innovation is characterised by a variety of intricacies. Facilitators play a central role in dealing with these challenges. Adopting an empirical approach, this chapter discusses the practical approaches and attitudes that facilitators develop to deal with such challenges in the domain of agricultural innovation. To that end, the paper presents a list of four intricacies inherent in running projects that seek to enhance sustainable development, based...

  17. Factors Mediating the Interactions between Adviser and Advisee during the Master's Thesis Project: A Quantitative Approach

    Science.gov (United States)

    Rodrigues Jr., Jose Florencio; Lehmann, Angela Valeria Levay; Fleith, Denise De Souza

    2005-01-01

    Building on previous studies centred on the interaction between adviser and advisee in masters thesis projects, in which a qualitative approach was used, the present study uses factor analysis to identify the factors that determine either a successful or unsuccessful outcome for the masters thesis project. There were five factors relating to the…

  18. Optimal control of quantum systems: a projection approach

    International Nuclear Information System (INIS)

    Cheng, C.-J.; Hwang, C.-C.; Liao, T.-L.; Chou, G.-L.

    2005-01-01

    This paper considers the optimal control of quantum systems. The controlled quantum systems are described by the probability-density-matrix-based Liouville-von Neumann equation. Using projection operators, the states of the quantum system are decomposed into two sub-spaces, namely the 'main state' space and the 'remaining state' space. Since the control energy is limited, a solution for optimizing the external control force is proposed in which the main state is brought to the desired main state at a certain target time, while the population of the remaining state is simultaneously suppressed in order to diminish its effects on the final population of the main state. The optimization problem is formulated by maximizing a general cost functional of states and control force. An efficient algorithm is developed to solve the optimization problem. Finally, using the hydrogen fluoride (HF) molecular population transfer problem as an illustrative example, the effectiveness of the proposed scheme for a quantum system initially in a mixed state or in a pure state is investigated through numerical simulations

  19. Optimization of nanostructured lipid carriers for topical delivery of nimesulide using Box-Behnken design approach.

    Science.gov (United States)

    Moghddam, Seyedeh Marziyeh Mahdavi; Ahad, Abdul; Aqil, Mohd; Imam, Syed Sarim; Sultana, Yasmin

    2017-05-01

    The aim of the present study was to develop and optimize topically applied nimesulide-loaded nanostructured lipid carriers. Box-Behnken experimental design was applied for optimization of nanostructured lipid carriers. The independent variables were ratio of stearic acid: oleic acid (X 1 ), poloxamer 188 concentration (X 2 ) and lecithin concentration (X 3 ) while particle size (Y 1 ) and entrapment efficiency (Y 2 ) were the chosen responses. Further, skin penetration study, in vitro release, confocal laser scanning microscopy and stability study were also performed. The optimized nanostructured lipid carriers of nimesulide provide reasonable particle size, flux, and entrapment efficiency. Optimized formulation (F9) with mean particle size of 214.4 ± 11 nm showed 89.4 ± 3.40% entrapment efficiency and achieved mean flux 2.66 ± 0.09 μg/cm 2 /h. In vitro release study showed prolonged drug release from the optimized formulation following Higuchi release kinetics with R 2 value of 0.984. Confocal laser scanning microscopy revealed an enhanced penetration of Rhodamine B-loaded nanostructured lipid carriers to the deeper layers of the skin. The stability study confirmed that the optimized formulation was considerably stable at refrigerator temperature as compared to room temperature. Our results concluded that nanostructured lipid carriers are an efficient carrier for topical delivery of nimesulide.

  20. Fast dissolving strips: A novel approach for the delivery of verapamil

    Directory of Open Access Journals (Sweden)

    S Kunte

    2010-01-01

    Full Text Available Objective: Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablets/capsules etc. Verapamil is a calcium channel blocker used as an antianginal, antiarrhythmic, and antihypertensive agent with extensive first pass metabolism which results in less bioavailability. This work investigated the possibility of developing verapamil fast dissolving strips allowing fast, reproducible drug dissolution in the oral cavity; thus bypassing first pass metabolism. Materials and methods: The fast dissolving strips were prepared by solvent casting technique with the help of HPMC E6 and maltodextrin. The strips were evaluated for drug content uniformity, film thickness, folding endurance, in vitro disintegration time, in vitro dissolution studies, surface pH study, and palatability study. Results: Official criteria for evaluation parameters were fulfilled by all formulations. Disintegration time showed by formulations was found to be in range of 20.4-28.6 sec. Based on the evaluation parameters, the formulation containing 2% HPMC E6 and 3.5% maltodextrin showed optimum performance against other formulations. Conclusion: It was concluded that the fast dissolving strips of verapamil can be made by solvent casting technique with enhanced dissolution rate, taste masking, and hence better patient compliance and effective therapy

  1. QoE-Driven Energy-Aware Multipath Content Delivery Approach for MPTCP-Based Mobile Phones

    Institute of Scientific and Technical Information of China (English)

    Yuanlong Cao; Shengyang Chen; Qinghua Liu; Yi Zuo; Hao Wang; Minghe Huang

    2017-01-01

    Mobile phones equipped with multiple wireless interfaces can increase their goodput performance by making use of concurrent transmissions over multiple paths,enabled by the Multipath TCP (MPTCP).However,utilizing MPTCP for data delivery may generally result in higher energy consumption,while the battery power of a mobile phone is limited.Thus,how to optimize the energy usage becomes very crucial and urgent.In this paper,we propose MPTCP-QE,a novel quality of experience (QoE)-driven energy-aware multipath content delivery approach for MPTCP-based mobile phones.The main idea of MPTCP-QE is described as follows:it first provides an application rate-aware energy-efficient subflow management strategy to tradeoff throughput performance and energy consumption for mobile phones;then uses an available bandwidth-aware congestion window fast recovery strategy to make a sender avoid unnecessary slow-start and utilize wireless resource quickly;and further introduces a novel receiver-driven energy-efficient SACK strategy to help a receiver possible to detect SACK loss timely and trigger loss recovery in a more energy-efficient way.The simulation results show that with the MPTCP-QE,the energy usage is enhanced while the performance level is maintained compared to existing MPTCP solutions.

  2. Experimentation on accuracy of non functional requirement prioritization approaches for different complexity projects

    Directory of Open Access Journals (Sweden)

    Raj Kumar Chopra

    2016-09-01

    Full Text Available Non functional requirements must be selected for implementation together with functional requirements to enhance the success of software projects. Three approaches exist for performing the prioritization of non functional requirements using the suitable prioritization technique. This paper performs experimentation on three different complexity versions of the industrial software project using cost-value prioritization technique employing three approaches. Experimentation is conducted to analyze the accuracy of individual approaches and the variation of accuracy with the complexity of the software project. The results indicate that selecting non functional requirements separately, but in accordance with functionality has higher accuracy amongst the other two approaches. Further, likewise other approaches, it witnesses the decrease in accuracy with increase in software complexity but the decrease is minimal.

  3. A CMMI-based approach for medical software project life cycle study.

    Science.gov (United States)

    Chen, Jui-Jen; Su, Wu-Chen; Wang, Pei-Wen; Yen, Hung-Chi

    2013-01-01

    In terms of medical techniques, Taiwan has gained international recognition in recent years. However, the medical information system industry in Taiwan is still at a developing stage compared with the software industries in other nations. In addition, systematic development processes are indispensable elements of software development. They can help developers increase their productivity and efficiency and also avoid unnecessary risks arising during the development process. Thus, this paper presents an application of Light-Weight Capability Maturity Model Integration (LW-CMMI) to Chang Gung Medical Research Project (CMRP) in the Nuclear medicine field. This application was intended to integrate user requirements, system design and testing of software development processes into three layers (Domain, Concept and Instance) model. Then, expressing in structural System Modeling Language (SysML) diagrams and converts part of the manual effort necessary for project management maintenance into computational effort, for example: (semi-) automatic delivery of traceability management. In this application, it supports establishing artifacts of "requirement specification document", "project execution plan document", "system design document" and "system test document", and can deliver a prototype of lightweight project management tool on the Nuclear Medicine software project. The results of this application can be a reference for other medical institutions in developing medical information systems and support of project management to achieve the aim of patient safety.

  4. PVA/Dextran hydrogel patches as delivery system of antioxidant astaxanthin: a cardiovascular approach.

    Science.gov (United States)

    Zuluaga, M; Gregnanin, G; Cencetti, C; Di Meo, C; Gueguen, V; Letourneur, D; Meddahi-Pellé, A; Pavon-Djavid, G; Matricardi, P

    2017-12-28

    After myocardial infarction, the heart's mechanical properties and its intrinsic capability to recover are compromised. To improve this recovery, several groups have developed cardiac patches based on different biomaterials strategies. Here, we developed polyvinylalcohol/dextran (PVA/Dex) elastic hydrogel patches, obtained through the freeze thawing (FT) process, with the aim to deliver locally a potent natural antioxidant molecule, astaxanthin, and to assist the heart's response against the generated myofibril stress. Extensive rheological and dynamo-mechanical characterization of the effect of the PVA molecular weight, number of freeze-thawing cycles and Dex addition on the mechanical properties of the resulting hydrogels, were carried out. Hydrogel systems based on PVA 145 kDa and PVA 47 kDa blended with Dex 40 kDa, were chosen as the most promising candidates for this application. In order to improve astaxanthin solubility, an inclusion system using hydroxypropyl-β-cyclodextrin was prepared. This system was posteriorly loaded within the PVA/Dex hydrogels. PVA145/Dex 1FT and PVA47/Dex 3FT showed the best rheological and mechanical properties when compared to the other studied systems; environmental scanning electron microscope and confocal imaging evidenced a porous structure of the hydrogels allowing astaxanthin release. In vitro cellular behavior was analyzed after 24 h of contact with astaxanthin-loaded hydrogels. In vivo subcutaneous biocompatibility was performed in rats using PVA145/Dex 1FT, as the best compromise between mechanical support and astaxanthin delivery. Finally, ex vivo and in vivo experiments showed good mechanical and compatibility properties of this hydrogel. The obtained results showed that the studied materials have a potential to be used as myocardial patches to assist infarcted heart mechanical function and to reduce oxidative stress by the in situ release of astaxanthin.

  5. From nano- to macro-scale: nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering.

    Science.gov (United States)

    Santo, Vítor E; Gomes, Manuela E; Mano, João F; Reis, Rui L

    2012-07-01

    The field of biomaterials has advanced towards the molecular and nanoscale design of bioactive systems for tissue engineering, regenerative medicine and drug delivery. Spatial cues are displayed in the 3D extracellular matrix and can include signaling gradients, such as those observed during chemotaxis. Architectures range from the nanometer to the centimeter length scales as exemplified by extracellular matrix fibers, cells and macroscopic shapes. The main focus of this review is the application of a biomimetic approach by the combination of architectural cues, obtained through the application of micro- and nanofabrication techniques, with the ability to sequester and release growth factors and other bioactive agents in a spatiotemporal controlled manner for bone and cartilage engineering.

  6. Hybrid Approach of Aortic Diseases: Zone 1 Delivery and Volumetric Analysis on the Descending Aorta

    Directory of Open Access Journals (Sweden)

    José Augusto Duncan

    Full Text Available Abstract Introduction: Conventional techniques of surgical correction of arch and descending aortic diseases remains as high-risk procedures. Endovascular treatments of abdominal and descending thoracic aorta have lower surgical risk. Evolution of both techniques - open debranching of the arch and endovascular approach of the descending aorta - may extend a less invasive endovascular treatment for a more extensive disease with necessity of proximal landing zone in the arch. Objective: To evaluate descending thoracic aortic remodeling by means of volumetric analysis after hybrid approach of aortic arch debranching and stenting the descending aorta. Methods: Retrospective review of seven consecutive patients treated between September 2014 and August 2016 for diseases of proximal descending aorta (aneurysms and dissections by hybrid approach to deliver the endograft at zone 1. Computed tomography angiography were analyzed using a specific software to calculate descending thoracic aorta volumes pre- and postoperatively. Results: Follow-up was done in 100% of patients with a median time of 321 days (range, 41-625 days. No deaths or permanent neurological complications were observed. There were no endoleaks or stent migrations. Freedom from reintervention was 100% at 300 days and 66% at 600 days. Median volume reduction was of 45.5 cm3, representing a median volume shrinkage by 9.3%. Conclusion: Hybrid approach of arch and descending thoracic aorta diseases is feasible and leads to a favorable aortic remodeling with significant volume reduction.

  7. Creating patient value in glaucoma care : applying quality costing and care delivery value chain approaches

    NARCIS (Netherlands)

    D.F. de Korne (Dirk); J.C.A. Sol (Kees); T. Custers (Thomas); E. van Sprundel (Esther); B.M. van Ineveld (Martin); H.G. Lemij (Hans); N.S. Klazinga (Niek)

    2009-01-01

    textabstractPurpose: The purpose of this paper is to explore in a specific hospital care process the applicability in practice of the theories of quality costing and value chains. Design/methodology/approach: In a retrospective case study an in-depth evaluation of the use of a quality cost model

  8. Project chariot remediation - the use of DOE's observational approach for environmental restoration with elements of the new DOE safer approach

    International Nuclear Information System (INIS)

    Hopkins, A.; Stewart, C.; Cabble, K.

    1994-01-01

    The primary purpose of Project Chariot was to investigate the technical problems and assess the effect of the proposed harbor excavation using nuclear explosives in Alaska. However, no nuclear devices were brought to the Project Chariot site. Between 1959 and 1961 various environmental tests were conducted. During the course of these environmental studies, the U.S. Geological Survey (USGS) granted the use of up to 5 curies of radioactive material at the Chariot site in Cape Thompson, Alaska; however only 26 millicuries were ever actually used. The tests were conducted in 12 test plots which were later gathered together and were mixed with in situ-soils generating approximately 1,600 cubic feet of soil. This area was then covered with four feet of clean soil, creating a mound. In 1962, the site was abandoned. A researcher at the University of Alaska at Fairbanks obtained in formation regarding the tests conducted and the materials left at the Project Chariot site. In response to concerns raised through the publication of this information, it was decided by the Department of Energy (DOE) that total remediation of the mound be completed within the year. During the summer of 1993, IT Corporation carried out the assessment and remediation of the Project Chariot site using a streamlined approach to waste site decision making called the Observational Approach (OA), and added elements of the new DOE Streamlined Approach for Environmental Restoration (SAFER). This remediation and remediation approach is described

  9. Relational approach in managing construction project safety: a social capital perspective.

    Science.gov (United States)

    Koh, Tas Yong; Rowlinson, Steve

    2012-09-01

    Existing initiatives in the management of construction project safety are largely based on normative compliance and error prevention, a risk management approach. Although advantageous, these approaches are not wholly successful in further lowering accident rates. A major limitation lies with the approaches' lack of emphasis on the social and team processes inherent in construction project settings. We advance the enquiry by invoking the concept of social capital and project organisational processes, and their impacts on project safety performance. Because social capital is a primordial concept and affects project participants' interactions, its impact on project safety performance is hypothesised to be indirect, i.e. the impact of social capital on safety performance is mediated by organisational processes in adaptation and cooperation. A questionnaire survey was conducted within Hong Kong construction industry to test the hypotheses. 376 usable responses were received and used for analyses. The results reveal that, while the structural dimension is not significant, the mediational thesis is generally supported with the cognitive and relational dimensions affecting project participants' adaptation and cooperation, and the latter two processes affect safety performance. However, the cognitive dimension also directly affects safety performance. The implications of these results for project safety management are discussed. Copyright © 2011 Elsevier Ltd. All rights reserved.

  10. Cost effective solutions for field development. System supplier approach to projects and operations

    International Nuclear Information System (INIS)

    Moe, P.O.

    1994-01-01

    The conference paper outlines the most important elements for a new approach to project realisation that enable a cost reduction of 30-50% compared to conventional methods. The achievements are based on studies and evaluations to the Norwegian Vigdis development project. The system elements covered are the electrical and automation systems including safety and process control and all traditional phases of a project from concept design to the operational phase. The concept involves new principles for project execution where traditional borderlines and interfaces between the various participants have been redefined. Management attention has been verified as an important prerequisite for a successful implementation of this strategy. 2 figs

  11. A team leadership approach to managing the transition from construction to operations for an environmental project

    International Nuclear Information System (INIS)

    Kelly, J.W.

    1994-06-01

    This presentation describes a team approach, at the totalproject level that focused team members with common objectives, for the transition to start-up and operation of the project. The Integrated Management Team (IMT) approach has been successful for this US Department of Energy (DOE) environmental restoration project at the Hanford Site in Richland, Washington. The $53.8-million project will collect, treat, and dispose of low-level mixed waste water discharges from the Hanford Site. Construction is scheduled for completion in September 1994 and facility start-up in June 1995. The project challenge is for leadership that is committed to the transition from construction to operation of the environmental restoration project

  12. Smart energy households' pilot projects in the Netherlands with a design-driven approach

    NARCIS (Netherlands)

    Geelen, D.V.; Scheepens, A.; Kobus, C.; Obinna, U.; Mugge, R.; Schoormans, J.; Reinders, Angelina H.M.E.

    2013-01-01

    Residential smart grid projects can be evaluated by a design-driven approach, which focuses on gaining insights for successful product and service development by taking the end-users as a starting point. Because only little experience exists with this design-driven approach, this paper addresses how

  13. The paradigm of consumer-driven and responsive supply chains: An integrated project approach

    NARCIS (Netherlands)

    Zimmermann, K.L.; Lans, van der I.A.

    2009-01-01

    This paper describes an integrated project approach that forms the basis of the studies on consumer-driven innovative and responsive supply chains in ISAFRUIT Pillar 1. This integrated approach leads to a wide range of indepth results on trends, preferences, and innovativeness of the European

  14. The art of 'doing' sustainable agricultural innovation: approaches and attitudes to facilitating transitional projects

    NARCIS (Netherlands)

    Loeber, A.; Vermeulen, T.; Barbier, M.; Elzen, B.

    2012-01-01

    The management of projects for sustainable innovation is characterised by a variety of intricacies. Facilitators play a central role in dealing with these challenges. Adopting an empirical approach, this chapter discusses the practical approaches and attitudes that facilitators develop to deal with

  15. Innovation in project-based companies - A case study in different approaches to organisational change

    DEFF Research Database (Denmark)

    Grex, Sara

    2004-01-01

    This paper asks how project-based organizations can be developed in order to establish and sustain innovation. The question is being explored by examining and comparing two approaches to organizational change. One approach emphasizes planning, regulation and control and creation of changes through...

  16. OA38 From service delivery to community enablement: a public health approach to palliative care.

    Science.gov (United States)

    McLoughlin, Kathleen; Rhatigan, Jim; Richardson, Marie; Lloyd, Rebecca

    2015-04-01

    : Milford Care Centre is the only hospice in Ireland to make a strategic decision to embrace a public health approach to palliative care, through the development, implementation and evaluation of the Compassionate Communities Project. This presentation seeks to examine why Milford made the decision to move toward a community enablement model, describes the development and implementation of the Compassionate Communities Project to date, presents key findings from recent evaluations and highlights our plans for the future. The presentation uses a reflective, story telling approach to meet it's aims, coupled with data and statistics gathered from the evaluations, and includes a new short film 'Tell Me' developed by recent Computer Science graduates for the Project to use to engage with communities during Café Conversations. The presentation will highlight the relevance of Health Promoting Palliative Care theory to the development of a three-tier model of programme activity, examine the challenges in implementing such an approach and will discuss the impact of upstream intervention to downstream service provision using case studies. © 2015, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  17. Life Cycle Thinking and Integrated Product Deliveries in renovation projects: Extending the concept of Integrated Product Deliveries with Product Service Systems

    DEFF Research Database (Denmark)

    Schipull Kauschen, Jan

    2012-01-01

    extension to the concept of IPDs discussed. Due to extended product responsibility, the concept of PSSs will offer new possibilities of planning and pre-defining life cycles of IPDs more precisely than for regular building components. Reducing or eliminating point-of-sales will induce producers to optimize...... on renovation projects from Denmark, using different forms of IPDs for façade renovation and discusses the different stakeholder’s perspectives on life cycle thinking and their interests and values regarding sustainable building. Furthermore is the concept of Product Service Systems (PSS) as a valuable...

  18. Modification of atrioventricular nodal electrophysiology by selective radiofrequency delivery on the anterior or posterior approaches.

    Science.gov (United States)

    Chorro, F J; Sanchis, J; Such, L; Artal, L; Llavador, J J; Llavador, E; Monmeneu, J V; López-Merino, V

    1997-05-01

    An analysis was made in 14 isolated and perfused rabbit hearts of the electrophysiological effects of selective radiofrequency (RF) delivery in the anterior (group I, n = 7) or posterior zone (group II, n = 7) of the Koch triangle, with the aim of modifying atrioventricular nodal (AVN) conduction without suppressing 1:1 transmission. After opening the right atrium, RF was delivered (0.5 W) with a 1-mm diameter unipolar electrode positioned in the selected zone until a prolongation of no less than 15% was obtained in the Wenckebach cycle length (WCL). Before and after (30 min) RF, anterograde and retrograde AVN refractoriness and conduction were evaluated, stimulating from the crista terminalis (CT), the interatrial septum (IAS), and from the RV epicardium. After RF, the following percentage increments were observed in group I: AH(CT) = 36% +/- 9%, AH(IAS) = 38% +/- 11%, WCL(CT) = 28% +/- 8%, WCL(IAS) = 22% +/- 6%, functional refractory period (FRP) of the AVN(CT) = 13% +/- 11%, FRP-AVN(IAS) = 13% +/- 8%, retrograde WCL = 20% +/- 19%, and retrograde FRPVA = 13% +/- 16%. The increments observed in group II and the significances of the differences with respect to group I were: AH(CT) = 11% +/- 14% (P IAS) = 19% +/- 32% (NS), WCL(CT) = 42% +/- 14% (P IAS) = 42% +/- 16% (P < 0.01), FRP-AVN(CT) = 28% +/- 28% (NS), FRP-AVN(LAS) = 21% +/- 19% (NS), retrograde WCL = 35% +/- 24% (NS), and retrograde FRP = 16% +/- 13% (NS). In both groups, the AH interval variations were not correlated with those of the rest of the parameters analyzed. Truncated nodal function curves suggestive of a dual AV nodal pathway were obtained in three experiments, though in only one of them was this observed under basal conditions. In the other two experiments, with dual AV nodal physiology only after RF (one from each group), AV nodal reentrant tachycardias were triggered with atrial extrastimulus at coupling intervals equal to or shorter than at those that cause a sudden lengthening of the AH

  19. Pre-emptive resource-constrained multimode project scheduling using genetic algorithm: A dynamic forward approach

    Directory of Open Access Journals (Sweden)

    Aidin Delgoshaei

    2016-09-01

    Full Text Available Purpose: The issue resource over-allocating is a big concern for project engineers in the process of scheduling project activities. Resource over-allocating drawback is frequently seen after scheduling of a project in practice which causes a schedule to be useless. Modifying an over-allocated schedule is very complicated and needs a lot of efforts and time. In this paper, a new and fast tracking method is proposed to schedule large scale projects which can help project engineers to schedule the project rapidly and with more confidence. Design/methodology/approach: In this article, a forward approach for maximizing net present value (NPV in multi-mode resource constrained project scheduling problem while assuming discounted positive cash flows (MRCPSP-DCF is proposed. The progress payment method is used and all resources are considered as pre-emptible. The proposed approach maximizes NPV using unscheduled resources through resource calendar in forward mode. For this purpose, a Genetic Algorithm is applied to solve. Findings: The findings show that the proposed method is an effective way to maximize NPV in MRCPSP-DCF problems while activity splitting is allowed. The proposed algorithm is very fast and can schedule experimental cases with 1000 variables and 100 resources in few seconds. The results are then compared with branch and bound method and simulated annealing algorithm and it is found the proposed genetic algorithm can provide results with better quality. Then algorithm is then applied for scheduling a hospital in practice. Originality/value: The method can be used alone or as a macro in Microsoft Office Project® Software to schedule MRCPSP-DCF problems or to modify resource over-allocated activities after scheduling a project. This can help project engineers to schedule project activities rapidly with more accuracy in practice.

  20. Life Cycle Thinking and Integrated Product Deliveries in renovation projects: Extending the concept of Integrated Product Deliveries with Product Service Systems

    DEFF Research Database (Denmark)

    Schipull Kauschen, Jan

    2012-01-01

    on renovation projects from Denmark, using different forms of IPDs for façade renovation and discusses the different stakeholder’s perspectives on life cycle thinking and their interests and values regarding sustainable building. Furthermore is the concept of Product Service Systems (PSS) as a valuable...... IPDs with regard to longevity and adaptability. CONCLUSION The new type of service-focused IPD and the related life-cycle responsibility (development, building phase, maintenance and dismantling/adaption/recycling) creates incentive to integrate life cycle thinking into the development process of IPDs......, resulting in more sustainable building solutions with a greater extend of positive environmental, economical and social impacts. The research presented will also show the importance of adaption and configuration of these complex building components by architects and planners, as they will have a great...

  1. Formulation and Optimization of Multiparticulate Drug Delivery System Approach for High Drug Loading.

    Science.gov (United States)

    Shah, Neha; Mehta, Tejal; Gohel, Mukesh

    2017-08-01

    The aim of the present work was to develop and optimize multiparticulate formulation viz. pellets of naproxen by employing QbD and risk assessment approach. Mixture design with extreme vertices was applied to the formulation with high loading of drug (about 90%) and extrusion-spheronization as a process for manufacturing pellets. Independent variables chosen were level of microcrystalline cellulose (MCC)-X 1 , polyvinylpyrrolidone K-90 (PVP K-90)-X 2 , croscarmellose sodium (CCS)-X 3 , and polacrilin potassium (PP)-X 4 . Dependent variables considered were disintegration time (DT)-Y 1 , sphericity-Y 2 , and percent drug release-Y 3 . The formulation was optimized based on the batches generated by MiniTab 17 software. The batch with maximum composite desirability (0.98) proved to be optimum. From the evaluation of design batches, it was observed that, even in low variation, the excipients affect the pelletization property of the blend and also the final drug release. In conclusion, pellets with high drug loading can be effectively manufactured and optimized systematically using QbD approach.

  2. Developing a Crowdsourcing Approach and Tool for Pharmacovigilance Education Material Delivery.

    Science.gov (United States)

    Bate, Andrew; Beckmann, Jürgen; Dodoo, Alexander; Härmark, Linda; Hartigan-Go, Kenneth; Hegerius, Anna; Lindquist, Marie; van Puijenbroek, Eugène; Tuccori, Marco; Hagemann, Ulrich

    2017-03-01

    The number of pharmacovigilance professionals worldwide is increasing with a high staff turnover. There is a constant stream of new colleagues with an interest or need to learn about the discipline. Consequently, there is an increasing need for training in pharmacovigilance. An important step towards this has been made through developing and publishing the World Health Organization (WHO)-International Society of Pharmacovigilance (ISoP) Pharmacovigilance Curriculum. Using the Pharmacovigilance Curriculum effectively, it should be supplemented by providing comprehensive training material from various sources, and making the Pharmacovigilance Curriculum attractive and a high-utility product. We describe a pilot of the development and initial evaluation of a crowdsourcing tool for the provision of pharmacovigilance education material. Pharmacovigilance experts shared links to their material to sections of relevance in the hierarchy and a small group of organisations conducted an initial testing. In this pilot, we have shown the usability of such a web-based tool. The strengths of this approach include the potential for a routine 'democratic' approach to sharing educational material to a wider community and an openness for access.

  3. Quality & timely delivery of products and services

    Energy Technology Data Exchange (ETDEWEB)

    Scott, K.; Shabbir, K. [WorleyParsons, Toronto, ON (Canada)

    2015-07-01

    This paper discusses quality and timely delivery of services. The approach is to support our customers, to ensure quality, schedule and cost predictability with no compromise to safety, to avoid optimistic project schedules and conservative cost estimates. It is important to maintain a strategic focus in helping to improve the customer's assets and improve the methodology to improve assets.

  4. Quality & timely delivery of products and services

    International Nuclear Information System (INIS)

    Scott, K.; Shabbir, K.

    2015-01-01

    This paper discusses quality and timely delivery of services. The approach is to support our customers, to ensure quality, schedule and cost predictability with no compromise to safety, to avoid optimistic project schedules and conservative cost estimates. It is important to maintain a strategic focus in helping to improve the customer's assets and improve the methodology to improve assets.

  5. The technique of project activity: A new approach in Russian preschool.

    Directory of Open Access Journals (Sweden)

    Veraksa N.E.

    2015-06-01

    Full Text Available Project activity has a long history of implementation in education (Kilpatrick, 1918. This article describes the approach to project activity that became widespread in preschool education in Russia in the late 1990s. This approach is based on the cultural-historical theory of Vygotsky (1978, Venger’s (1988 understanding of intellectual giftedness, as well as an understanding of project activity proposed by Leontiev (2000. At the heart of project activity lies children’s exploration of the space of possibilities — that is, their search for action options that correspond to their personal motives and express their individuality. The main features of project activity are the problem situation to be presented to the child; the subjectivity of all its participants, including teachers; and its nature, which includes its social context. Three main types of project activity are presented: research, creative, and normative; each has its own structure and value for children’s development. Examples of their implementation in preschool settings are provided. The impact of project activity on all its participants in preschool — children, teachers, parents — is addressed. The article shows the effectiveness of project activity for educational work with both intellectually gifted and normally developing children.

  6. A Basin Approach to a Hydrological Service Delivery System in the Amur River Basin

    Directory of Open Access Journals (Sweden)

    Sergei Borsch

    2018-03-01

    Full Text Available This paper presents the basin approach to the design, development, and operation of a hydrological forecasting and early warning system in a large transboundary river basin of high flood potential, where accurate, reliable, and timely available daily water-level and reservoir-inflow forecasts are essential for water-related economic and social activities (the Amur River basin case study. Key aspects of basin-scale system planning and implementation are considered, from choosing efficient forecast models and techniques, to developing and operating data-management procedures, to disseminating operational forecasts using web-GIS. The latter, making the relevant forecast data available in real time (via Internet, visual, and well interpretable, serves as a good tool for raising awareness of possible floods in a large region with transport and industrial hubs located alongside the Amur River (Khabarovsk, Komsomolsk-on-Amur.

  7. Phospholipid complex enriched micelles: A novel drug delivery approach for promoting the antidiabetic effect of repaglinide.

    Science.gov (United States)

    Kassem, Ahmed Alaa; Abd El-Alim, Sameh Hosam; Basha, Mona; Salama, Abeer

    2017-03-01

    To enhance the oral antidiabetic effect of repaglinide (RG), a newly emerging approach, based on the combination of phospholipid complexation and micelle techniques, was employed. Repaglinide-phospholipid complex (RG-PLC) was prepared by the solvent-evaporation method then characterized using Differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR) and X-ray powder diffraction (XPRD). The results revealed obvious disappearance of the characteristic peaks of the prepared RG-PLCs confirming the formation of drug-phospholipid complex. RG-PLC enriched micelles (RG-PLC-Ms) were prepared by the solvent-evaporation technique employing poloxamer 188 as surfactant. The prepared RG-PLC-Ms showed high drug encapsulation efficiencies (93.81-99.38%), with nanometric particle diameters (500.61-665.32nm) of monodisperse distribution and high stability (Zeta potential < -29.8mV). The in vitro release of RG from RG-PLC-Ms was pH-dependant according to the release media. A higher release pattern was reported in pH=1.2 compared to a more retarded release in pH=6.8 owing to two different kinetics of drug release. Oral antidiabetic effect of two optimized RG-PLC-M formulations was evaluated in an alloxan-induced diabetic rat model for 7-day treatment protocol. The two investigated formulations depicted normal blood glucose, serum malondialdehyde and insulin levels as well as an improved lipid profile, at the end of daily oral treatment, in contrast to RG marketed tablets implying enhanced antidiabetic effect of the drug. Hence, phospholipid-complex enriched micelles approach holds a promising potential for promoting the antidiabetic effect of RG. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. No. 355-Physiologic Basis of Pain in Labour and Delivery: An Evidence-Based Approach to its Management.

    Science.gov (United States)

    Bonapace, Julie; Gagné, Guy-Paul; Chaillet, Nils; Gagnon, Raymonde; Hébert, Emmanuelle; Buckley, Sarah

    2018-02-01

    To review the evidence relating to nonpharmacological approaches in the management of pain during labour and delivery. To formulate recommendations for the usage of nonpharmacological approaches to pain management. Nonpharmacological methods available for pain management during labour and delivery exist. These should be included in the counselling and care of women. PubMed and Medline were searched for articles in French and English on subjects related to "breastfeeding," "pain," "epidural," "anaesthesia," "analgesia," "labour," "labor," and combined with "gate control theory," "alternative therapies," "massage," "position," "mobility," "TENS," "bathing," "DNIC," "acupuncture," "acupressure," "sterile water injection," "higher center," "control mind," "cognitive structuring," "holistic health," "complementary therapy(ies)," "breathing," "relaxation," "mental imagery," "visualization," "mind focusing," "hypnosis," "auto-hypnosis," "sophrology," "mind and body interventions," "music," "odors," "biofeedback," "Lamaze," "Bonapace," "prenatal training," "gymnastic," "chanting," "haptonomy," "environment," "transcutaneous electrical stimulus-stimulation," "antenatal education," "support," "continuous support," "psychosocial support," "psychosomatic medicine," "supportive care," "companion," "intrapartum care," "nurse," "midwife(ves)," "father," "doula," "caregiver," " hormones," "oxytocin," "endorphin," "prolactin," "catecholamine," "adrenaline," and "noradrenaline" from 1990 to December 2015. Additional studies were identified by screening reference lists from selected studies and from expert suggestions. No language restrictions were applied. The quality of the evidence is rated using the criteria described in the Report of the Canadian Task Force on Preventive Health Care. Recommendations for practice are ranked according to the method described in this report. The nonpharmacological method encourages an incremental approach to pain management that contributes to

  9. System Description for the K-25/K-27 D and D Project Polyurethane Foam Delivery System, East Tennessee Technology Park, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    Boris, G.

    2008-01-01

    The Foam Delivery System used in the decontamination and decommissioning (D and D) project for the K-25/K-27 Buildings at the East Tennessee Technology Park (ETTP) is comprised of a trailer-mounted Gusmer(reg s ign) H20/35 Pro-TEC Proportioning Unit and the associated equipment to convey electrical power, air, and foam component material to the unit. This high-pressure, plural-component polyurethane foam pouring system will be used to fill process gas and non-process equipment/piping (PGE/P) within the K-25/K-27 Buildings with polyurethane foam to immobilize contaminants prior to removal. The system creates foam by mixing isocyanate and polyol resin (Resin) component materials. Currently, the project plans to utilize up to six foaming units simultaneously during peak foaming activities. Also included in this system description are the foam component material storage containers that will be used for storage of the component material drums in a staging area outside of the K-25/K-27 Buildings. The Foam Delivery System and foam component material storage enclosures (i.e., Foaming Component Protective Enclosures) used to store polymeric methylene diphenyl diisocyanate (PMDI) component material are identified as Safety Significant (SS) Structures, Systems and Components (SSC) in the Documented Safety Analysis (DSA) for the project, Documented Safety Analysis for the K-25 and K-27 Facilities at the East Tennessee Technology Park, Oak Ridge, Tennessee, DSA-ET-K-25/K-27-0001

  10. A systems thinking approach to eliminate delays on building ...

    African Journals Online (AJOL)

    It is obvious that the performance of firms and their market competitiveness hinge on project delivery time. Many approaches have been used to reduce the effect of the potential factors of delay on project delivery time. In this study, the system approach has been employed and validated. Inferential statistical analysis was ...

  11. Quality and effectiveness of different approaches to primary care delivery in Brazil

    Directory of Open Access Journals (Sweden)

    Trindade Thiago G

    2006-12-01

    Full Text Available Abstract Background Since 1994, Brazil has developed a primary care system based on multidisciplinary teams which include not only a physician and a nurse, but also 4–6 lay community health workers. This system now consists of 26,650 teams, covering 46% of the Brazilian population. Yet relatively few investigations have examined its effectiveness, especially in contrast with that of the traditional multi-specialty physician team approach it is replacing, or that of other existing family medicine approaches placing less emphasis on lay community health workers. Primary health care can be defined through its domains of access to first contact, continuity, coordination, comprehensiveness, community orientation and family orientation. These attributes can be ascertained via instruments such as the Primary Care Assessment Tool (PCATool, and correlated with the effectiveness of care. The objectives of our study are to validate the adult version of this instrument in Portuguese, identify the extent (quality of primary care present in different models of primary care services, and correlate this extent with measures of process and outcomes in patients with diabetes, hypertension and coronary heart disease (CHD. Methods/Design We are conducting a population-based cross-sectional study of primary care in the municipality of Porto Alegre. We will interview a random sample totaling 3000 adults residing in geographic areas covered by four distinct models of primary care of the Brazilian national health system or, alternatively, by one nationally prominent complementary health care service, as well as the physicians and nurses of the health teams of these services. Interviews query perceived quality of care (PCATool-Adult Version, patient satisfaction, and process indicators of management of diabetes, hypertension and known CHD. We are measuring blood pressure, anthropometrics and, in adults with known diabetes, glycated hemoglobin. Discussion We hope to

  12. Nanotechnology based approaches for detection and delivery of microRNA in healthcare and crop protection.

    Science.gov (United States)

    Chaudhary, Vrantika; Jangra, Sumit; Yadav, Neelam R

    2018-04-13

    Nanobiotechnology has the potential to revolutionize diverse sectors including medicine, agriculture, food, textile and pharmaceuticals. Disease diagnostics, therapeutics and crop protection strategies are fast emerging using nanomaterials preferably nanobiomaterials. It has potential for development of novel nanobiomolecules which offer several advantages over conventional treatment methods. RNA nanoparticles with many unique features are promising candidates in disease treatment. The miRNAs are involved in many biochemical and developmental pathways and their regulation in plants and animals. These appear to be a powerful tool for controlling various pathological diseases in human, plants and animals, however there are challenges associated with miRNA based nanotechnology. Several advancements made in the field of miRNA therapeutics make it an attractive approach, but a lot more has to be explored in nanotechnology assisted miRNA therapy. The miRNA based technologies can be employed for detection and combating crop diseases as well. Despite these potential advantages, nanobiotechnology applications in the agricultural sector are still in its infancy and have not yet made its mark in comparison with healthcare sector. The review provides a platform to discuss nature, role and use of miRNAs in nanobiotechnology applications.

  13. Global Fund financing of public-private mix approaches for delivery of tuberculosis care.

    Science.gov (United States)

    Lal, S S; Uplekar, Mukund; Katz, Itamar; Lonnroth, Knut; Komatsu, Ryuichi; Yesudian Dias, Hannah Monica; Atun, Rifat

    2011-06-01

    To map the extent and scope of public-private mix (PPM) interventions in tuberculosis (TB) control programmes supported by the Global Fund. We reviewed the Global Fund's official documents and data to analyse the distribution, characteristics and budgets of PPM approaches within Global Fund supported TB grants in recipient countries between 2003 and 2008. We supplemented this analysis with data on contribution of PPM to TB case notifications in 14 countries reported to World Health Organization in 2009, for the preparation of the global TB control report. Fifty-eight of 93 countries and multi-country recipients of Global Fund-supported TB grants had PPM activities in 2008. Engagement with 'for-profit' private sector was more prevalent in South Asia while involvement of prison health services has been common in Eastern Europe and central Asia. In the Middle East and North Africa, involving non-governmental organizations seemed to be the focus. Average and median spending on PPM within grants was 10% and 5% respectively, ranging from 0.03% to 69% of the total grant budget. In China, India, Nigeria and the Philippines, PPM contributed to detecting more than 25% TB cases while maintaining high treatment success rates. In spite of evidence of cost-effectiveness, PPM constitutes only a modest part of overall TB control activities. Scaling up PPM across countries could contribute to expanding access to TB care, increasing case detection, improving treatment outcomes and help achieve the global TB control targets. © 2011 Blackwell Publishing Ltd.

  14. Nanotechnology applications and approaches for neuroregeneration and drug delivery to the central nervous system.

    Science.gov (United States)

    Silva, Gabriel A

    2010-06-01

    Nanotechnology is the science and engineering concerned with the design, synthesis, and characterization of materials and devices that have a functional organization in at least one dimension on the nanometer (i.e., one billionth of a meter) scale. The potential impact of bottom up self-assembling nanotechnology, custom made molecules that self-assemble or self-organize into higher ordered structures in response to a defined chemical or physical cue, and top down lithographic type technologies where detail is engineered at smaller scales starting from bulk materials, stems from the fact that these nanoengineered materials and devices exhibit emergent mesocale and macroscale chemical and physical properties that are often different than their constituent nanoscale building block molecules or materials. As such, applications of nanotechnology to medicine and biology allow the interaction and integration of cells and tissues with nanoengineered substrates at a molecular (i.e., subcellular) level with a very high degree of functional specificity and control. This review considers applications of nanotechnology aimed at the neuroprotection and functional regeneration of the central nervous system (CNS) following traumatic or degenerative insults, and nanotechnology approaches for delivering drugs and other small molecules across the blood-brain barrier. It also discusses developing platform technologies that may prove to have broad applications to medicine and physiology, including some being developed for rescuing or replacing anatomical and/or functional CNS structures.

  15. Regulation Of Hydraulic Fracturing In South Africa: A Project Life-Cycle Approach?

    Directory of Open Access Journals (Sweden)

    Willemien du Plessis

    2015-12-01

    Full Text Available This note deals with the 2015 regulations pertaining to hydraulic fracturing in South Africa from a project life-cycle approach. A brief history of the fragmentation of the regulation of environmental and mining related matters is provided, followed by a discussion of the application of the 2015 regulations during the project life cycle, ie the pre-commencement phase, the design and authorisation phase, the testing phase, the operational phase and the decommissioning and closure phase.

  16. The strategy of parallel approaches in projects with unforeseeable uncertainty: the Manhattan case in retrospect

    OpenAIRE

    Sylvain Lenfle

    2011-01-01

    International audience; This paper discusses the literature on the management of projects with unforeseeable uncertainty. Recent work demonstrates that, when confronted with unforeseeable uncertainties, managers can adopt either a learning, trial-and-error-based strategy, or a parallel approach. In the latter, different solutions are developed in parallel and the best one is chosen when enough information becomes available. Studying the case of the Manhattan Project, which historically exempl...

  17. Exploring Community-Oriented Approaches in Demand Side Management Projects in Europe

    Directory of Open Access Journals (Sweden)

    Anna Mengolini

    2016-12-01

    Full Text Available This paper seeks to investigate if the theoretical and political trends towards a more collective dimension of energy use are reflected in the design and development of demand side management (DSM pilot projects in Europe. Specifically, the paper analyses DSM projects in the database of the Joint Research Centre (JRC of the European Commission to capture signs of a new attention towards the wider context in which consumers live and towards the social dimension associated with energy consumption. To this end, the paper investigates the projects’ scope (in terms of project’s partners, end-use sectors and targeted services as well as the consumer engagement strategies that projects use. These elements reflect the projects’ consideration for the socio-economic dimension of the community where the pilots take place and their inclination to build on community dynamics. The analysis shows that DSM projects in the EU are increasingly being designed and developed with a collegial approach to energy consumption in mind, although an integrated approach is still missing. In addition, research is still needed to link the use of this innovative approach to project results. A closer look at the developments and results of these projects can help to identify what works and what doesn’t in real life experiences, thus supporting effective policy making at the EU and national level.

  18. USING OF THE PROJECT-ORIENTED APPROACH IN THE INNOVATIVE ACTIVITY MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Варвара Михайлівна ПІТЕРСЬКА

    2016-02-01

    Full Text Available The article describes the current state of science in Ukraine, indicated the main directions of research funding. The methodological approach of working out of the project-oriented strategy of innovative development of scientific activity, including the implementation of international trends and support of research is proposed. Using of a project-oriented approach of research activities due to the need of reducing of the research cycle and strengthen expenditure control capabilities due to restrictions of funding research projects from the state. It should be noted that the structuring of research, given the project approach, allows engaging of the implementation of the research project professionals with good knowledge and skills and create a team activity focused on quality results. Innovations aren‘t still properly means the improvement of competitiveness in Ukraine. Thus, the problem of transition to an innovative development model retains its relevance, that significantly enhanced in the light of current external and internal trends. Using of the project-oriented innovation management due to the need to shorten the cycle of research and to strengthen the control over the expenditure of funds in connection with the limited funding of scientific research by the state.

  19. Systematic approach to treat chronic osteomyelitis through localized drug delivery system: Bench to bed side

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharya, Rupnarayan [Department of Plastic Surgery, R. G. Kar Medical College and Hospital (RGKMCH), Kolkata 700004 (India); Kundu, Biswanath, E-mail: biswa_kundu@rediffmail.com [Biocermics and Coating Division, CSIR — Central Glass and Ceramic Research Institute (CSIR-CGCRI), Kolkata 700032 (India); Nandi, Samit Kumar, E-mail: samitnandi1967@gmail.com [Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences (WBUAFS), Kolkata 700037 (India); Basu, Debabrata [Biocermics and Coating Division, CSIR — Central Glass and Ceramic Research Institute (CSIR-CGCRI), Kolkata 700032 (India)

    2013-10-15

    Chronic osteomyelitis is a challenging setback to the orthopedic surgeons in deciding an optimal therapeutic strategy. Conversely, patients feel frustrated of the therapeutic outcomes and development of adverse drug effects, if any. Present investigation deals with extensive approach incorporating in vivo animal experimentation and human application to treat chronic osteomyelitis, using antibiotic loaded porous hydroxyapatite scaffolds. Micro- to macro-porous hydroxyapatite scaffolds impregnated with antibiotic ceftriaxone–sulbactam sodium (CFS) were fabricated and subsequently evaluated by in vivo animal model after developing osteomyelitis in rabbit tibia. Finally 10 nos. of human osteomyelitis patients involving long bone and mandible were studied for histopathology, radiology, pus culture, 3D CT etc. up to 8–18 months post-operatively. It was established up to animal trial stage that 50N50H samples [with 50–55% porosity, average pore size 110 μm, higher interconnectivity (10–100 μm), and moderately high drug adsorption efficiency (50%)] showed efficient drug release up to 42 days than parenteral group based on infection eradication and new bone formation. In vivo human bone showed gradual evidence of new bone formation and fracture union with organized callus without recurrence of infection even after 8 months. This may be a new, alternative, cost effective and ideal therapeutic strategy for chronic osteomyelitis treatment in human patients. - Highlights: • Chronic osteomyelitis is challenging setback to decide optimal therapeutic strategy. • Micro- to macro-porous antibiotic CFS impregnated HAp scaffolds were fabricated. • Complete in vivo animal trial done after developing osteomyelitis in rabbit tibia. • Clinical trial showed fracture union without recurrence of infection after 8 months. • This may be a new, alternative, cost effective and ideal therapeutic strategy.

  20. A Dynamic Intelligent Decision Approach to Dependency Modeling of Project Tasks in Complex Engineering System Optimization

    Directory of Open Access Journals (Sweden)

    Tinggui Chen

    2013-01-01

    Full Text Available Complex engineering system optimization usually involves multiple projects or tasks. On the one hand, dependency modeling among projects or tasks highlights structures in systems and their environments which can help to understand the implications of connectivity on different aspects of system performance and also assist in designing, optimizing, and maintaining complex systems. On the other hand, multiple projects or tasks are either happening at the same time or scheduled into a sequence in order to use common resources. In this paper, we propose a dynamic intelligent decision approach to dependency modeling of project tasks in complex engineering system optimization. The approach takes this decision process as a two-stage decision-making problem. In the first stage, a task clustering approach based on modularization is proposed so as to find out a suitable decomposition scheme for a large-scale project. In the second stage, according to the decomposition result, a discrete artificial bee colony (ABC algorithm inspired by the intelligent foraging behavior of honeybees is developed for the resource constrained multiproject scheduling problem. Finally, a certain case from an engineering design of a chemical processing system is utilized to help to understand the proposed approach.

  1. Governance arrangements for IT project portfolio management qualitative insights and a quantitative modeling approach

    CERN Document Server

    Frey, Thorsten

    2014-01-01

    Due to the growing importance of IT-based innovations, contemporary firms face an excessive number of proposals for IT projects. As typically only a fraction of these projects can be implemented with the given capacity, IT project portfolio management as a relatively new discipline has received growing attention in research and practice in recent years.?Thorsten Frey demonstrates how companies are struggling to find the right balance between local autonomy and central overview about all projects in the organization. In this context, impacts of different contextual factors on the design of governance arrangements for IT project portfolio management are demonstrated. Moreover, consequences of the use of different organizational designs are analyzed. The author presents insights from a qualitative empirical study as well as a simulative approach.

  2. Projective Synchronization in Modulated Time-Delayed Chaotic Systems Using an Active Control Approach

    International Nuclear Information System (INIS)

    Feng Cun-Fang; Wang Ying-Hai

    2011-01-01

    Projective synchronization in modulated time-delayed systems is studied by applying an active control method. Based on the Lyapunov asymptotical stability theorem, the controller and sufficient condition for projective synchronization are calculated analytically. We give a general method with which we can achieve projective synchronization in modulated time-delayed chaotic systems. This method allows us to adjust the desired scaling factor arbitrarily. The effectiveness of our method is confirmed by using the famous delay-differential equations related to optical bistable or hybrid optical bistable devices. Numerical simulations fully support the analytical approach. (general)

  3. Designing “Theory of Machines and Mechanisms” course on Project Based Learning approach

    DEFF Research Database (Denmark)

    Shinde, Vikas

    2013-01-01

    by the industry and the learning outcomes specified by the National Board of Accreditation (NBA), India; this course is restructured on Project Based Learning approach. A mini project is designed to suit course objectives. An objective of this paper is to discuss the rationale of this course design......Theory of Machines and Mechanisms course is one of the essential courses of Mechanical Engineering undergraduate curriculum practiced at Indian Institute. Previously, this course was taught by traditional instruction based pedagogy. In order to achieve profession specific skills demanded...... and the process followed to design a project which meets diverse objectives....

  4. A community of practice approach to bioanalysis delivery: the role of the Preclinical Bioanalysis and Toxicokinetics department at AstraZeneca.

    Science.gov (United States)

    Wilson, Amanda; Silvester, Stephen; Woods, Karen

    2014-05-01

    Retaining regulated bioanalysis within AstraZeneca (AZ) is important for the effective delivery of nonclinical and clinical bioanalysis. The focus for the in-house team is the delivery of high-throughput bioanalysis and toxicokinetics support for investigational toxicology; however, by retaining GLP compliance, AZ will have an in-house understanding of every candidate drug that is progressed into development by supporting the first rodent GLP study for each project. The majority of nonclinical bioanalysis and all of the clinical bioanalysis are delivered by two external partnership models. This article describes the key benefits of retaining GLP compliance, the partnership interactions, discusses the management of non-GLP support in a GLP environment and how, having practical experience of regulatory facing method development, validation and study execution adds value to the AZ portfolio delivery.

  5. Strategic project selection based on evidential reasoning approach for high-end equipment manufacturing industry

    Directory of Open Access Journals (Sweden)

    Lu Guangyan

    2017-01-01

    Full Text Available With the rapid development of science and technology, emerging information technologies have significantly changed the daily life of people. In such context, strategic project selection for high-end equipment manufacturing industries faces more and more complexities and uncertainties with the consideration of several complex criteria. For example, a group of experts rather than a single expert should be invited to select strategic project for high-end equipment manufacturing industries and the experts may feel difficulty to express their preferences towards different strategic projects due to their limited cognitive capabilities. In order to handle these complexities and uncertainties, the criteria framework of strategic project selection is firstly constructed based on the characteristics of high-end equipment manufacturing industries and then evidential reasoning (ER approach is introduced in this paper to help experts express their uncertain preferences and aggregate these preferences to generate an appropriate strategic project. A real case of strategic project selection in a high-speed train manufacturing enterprise is investigated to demonstrate the validity of the ER approach in solving strategic project selection problem.

  6. Planning and urbanistic projects – the non-author approach and issues of synergy in cooperation

    Directory of Open Access Journals (Sweden)

    Liljana Jankovič Grobelšek

    2005-01-01

    Full Text Available The article presents the non-author approach to urbanistic and planning projects. The project leader guides the entire project team, yet particular coordinators are also important. Contrary to authorship in architectural projects, in physical planning authorship is often or even always completely shared. Not only because planning projects can change significantly during adoption procedures, but mainly because there are many participating actors (designers, planners, commissioners and/or investors etc. that are involved in any project’s undertaking. Experience proves that the non-author approach is beneficial for good project management and creation of conditions for constructive cooperation within an interdisciplinary working group and with all the other contributing parties. Two tested examples are presented. Their comparison is very interesting, since the first example shows a project where good cooperation between the client, investor and designers, as well as willing interested public, conditioned quality improvements, while the second (because of the public and consequently against its interests diminished its quality significantly. Our judgement is that the quantity of the often mentioned necessity of public involvement is actually sufficient. There are no obstacles for public participation in urbanistic and physical planning, as long as the public is interested. Troubles are often triggered elsewhere – how to safeguard the common, public interest before particular publics (e.g. neighbours, the immediately affected etc..

  7. MODELS AND METHODS OF SAFETY-ORIENTED PROJECT MANAGEMENT OF DEVELOPMENT OF COMPLEX SYSTEMS: METHODOLOGICAL APPROACH

    Directory of Open Access Journals (Sweden)

    Олег Богданович ЗАЧКО

    2016-03-01

    Full Text Available The methods and models of safety-oriented project management of the development of complex systems are proposed resulting from the convergence of existing approaches in project management in contrast to the mechanism of value-oriented management. A cognitive model of safety oriented project management of the development of complex systems is developed, which provides a synergistic effect that is to move the system from the original (pre condition in an optimal one from the viewpoint of life safety - post-project state. The approach of assessment the project complexity is proposed, which consists in taking into account the seasonal component of a time characteristic of life cycles of complex organizational and technical systems with occupancy. This enabled to take into account the seasonal component in simulation models of life cycle of the product operation in complex organizational and technical system, modeling the critical points of operation of systems with occupancy, which forms a new methodology for safety-oriented management of projects, programs and portfolios of projects with the formalization of the elements of complexity.

  8. Care for a Patient With Cancer As a Project: Management of Complex Task Interdependence in Cancer Care Delivery

    OpenAIRE

    Trosman, Julia R.; Carlos, Ruth C.; Simon, Melissa A.; Madden, Debra L.; Gradishar, William J.; Benson, Al B.; Rapkin, Bruce D.; Weiss, Elisa S.; Gareen, Ilana F.; Wagner, Lynne I.; Khan, Seema A.; Bunce, Mikele M.; Small, Art; Weldon, Christine B.

    2016-01-01

    Cancer care is highly complex and suffers from fragmentation and lack of coordination across provider specialties and clinical domains. As a result, patients often find that they must coordinate care on their own. Coordinated delivery teams may address these challenges and improve quality of cancer care. Task interdependence is a core principle of rigorous teamwork and is essential to addressing the complexity of cancer care, which is highly interdependent across specialties and modalities. W...

  9. Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS Drug Delivery Systems for in Vitro and in Vivo Applications

    Directory of Open Access Journals (Sweden)

    Ken-Tye Yong

    2012-11-01

    Full Text Available Despite the advancements made in drug delivery systems over the years, many challenges remain in drug delivery systems for treating chronic diseases at the personalized medicine level. The current urgent need is to develop novel strategies for targeted therapy of chronic diseases. Due to their unique properties, microelectromechanical systems (MEMS technology has been recently engineered as implantable drug delivery systems for disease therapy. This review examines the challenges faced in implementing implantable MEMS drug delivery systems in vivo and the solutions available to overcome these challenges.

  10. Examining approaches to renewables consultation. Lessons from Awel Aman Tawe community wind farm project

    Energy Technology Data Exchange (ETDEWEB)

    Hinshelwood, E; McCallum, D

    2001-07-01

    The overall aim was to develop and test a range of methods for a Participatory Assessment Process (PAP) in a large community on the subject of a Renewable Energy project in the area. Furthermore, to extract lessons regarding the methods and approaches undertaken. The specific objectives were: 1. To identify and shape appropriate tools, methods and approaches for undertaking a fair community assessment process regarding a Renewable Energy project in the locality. 2. To conduct an in-depth (ten month) community consultation and assessment process for a proposed wind farm. 3. To assess the methods and approaches used in the community consultation and assessment process for their efficiency and value to other developers and community groups. 4. To write up and disseminate the findings regarding the most valuable, efficient and appropriate methods and approaches undertaken. (Author)

  11. Tank waste remediation system retrieval and disposal mission waste feed delivery plan

    International Nuclear Information System (INIS)

    Potter, R.D.

    1998-01-01

    This document is a plan presenting the objectives, organization, and management and technical approaches for the Waste Feed Delivery (WFD) Program. This WFD Plan focuses on the Tank Waste Remediation System (TWRS) Project's Waste Retrieval and Disposal Mission

  12. COMPARISONS BETWEEN AND COMBINATIONS OF DIFFERENT APPROACHES TO ACCELERATE ENGINEERING PROJECTS

    Directory of Open Access Journals (Sweden)

    H. Steyn

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: In this article, traditional project management methods such as PERT and CPM, as well as fast-tracking and systems approaches, viz. concurrent engineering and critical chain, are reviewed with specific reference to their contribution to reducing the duration of the execution phase of engineering projects. Each of these techniques has some role to play in the acceleration of project execution. Combinations of approaches are evaluated by considering the potential of sets consisting of two different approaches each. While PERT and CPM approaches have been combined for many years in a technique called PERT/CPM, new combinations of approaches are discussed. Certain assumptions inherent to PERT and often wrong are not made by the critical chain approach.

    AFRIKAANSE OPSOMMING: In hierdie artikel word tradisionele projekbestuurbenaderings soos PERT en CPM asook projekversnelling en stelselbenaderings, naamlik gelyktydige ingenieurswese, en kritiekeketting-ondersoek met betrekking tot die bydrae wat elk tot die versnelling van die uitvoeringsfase van ingenieursprojekte kan lewer. Elk van hierdie benaderings kan ‘n spesifieke bydrae tot die versnelling van projekte lewer. Kombinasies, elk bestaande uit twee verskillende benaderings, word geëvalueer. Terwyl PERT en CPM reeds baie jare lank in kombinasie gebruik word, word nuwe kombinasies ook hier bespreek. Sekere aannames inherent aan die PERT-benadering is dikwels foutief. Hierdie aannames word nie deur die kritieke-ketting-benadering gemaak nie.

  13. Enhancing Project-Based Learning in Software Engineering Lab Teaching through an E-Portfolio Approach

    Science.gov (United States)

    Macias, J. A.

    2012-01-01

    Project-based learning is one of the main successful student-centered pedagogies broadly used in computing science courses. However, this approach can be insufficient when dealing with practical subjects that implicitly require many deliverables and a great deal of feedback and organizational resources. In this paper, a worked e-portfolio is…

  14. Balancing uncertainty of context in ERP project estimation: an approach and a case study

    NARCIS (Netherlands)

    Daneva, Maia

    2010-01-01

    The increasing demand for Enterprise Resource Planning (ERP) solutions as well as the high rates of troubled ERP implementations and outright cancellations calls for developing effort estimation practices to systematically deal with uncertainties in ERP projects. This paper describes an approach -

  15. A human rights based approach to project induced displacement and resettlement

    NARCIS (Netherlands)

    van der Ploeg, Lidewij; Vanclay, Frank

    2017-01-01

    AbstractRespecting, protecting and fulfilling human rights must become more prominent in both the processes and outcomes of resettlement. We have developed a Human Rights-Based Approach to Resettlement for use by project operators, rights holders and governments so that they can better understand

  16. A human rights based approach to project induced displacement and resettlement

    NARCIS (Netherlands)

    van der Ploeg, Lidewij; Vanclay, Frank

    2017-01-01

    Respecting, protecting and fulfilling human rights must become more prominent in both the processes and outcomes of resettlement. We have developed a Human Rights-Based Approach to Resettlement for use by project operators, rights holders and governments so that they can better understand what the

  17. Acute effects of ozone on mortality from the "Air pollution and health : A European approach" project

    NARCIS (Netherlands)

    Gryparis, A; Forsberg, B; Katsouyanni, K; Analitis, A; Touloumi, G; Schwartz, J; Samoli, E; Medina, S; Anderson, HR; Niciu, EM; Wichmann, HE; Kriz, B; Kosnik, M; Skorkovsky, J; Vonk, JM; Dortbudak, Z

    2004-01-01

    In the Air Pollution and Health: A European Approach (APHEA2) project, the effects of ambient ozone concentrations on mortality were investigated. Data were collected on daily ozone concentrations, the daily number of deaths, confounders, and potential effect modifiers from 23 cities/areas for at

  18. A Practice-Centered Approach to Professional Development: Teacher-Librarian Collaboration in Capstone Projects

    Science.gov (United States)

    Harada, Violet H.

    2016-01-01

    This paper reports on a professional development initiative that targeted teams of teachers and librarians working with high school students on strengthening an inquiry approach to capstone projects. While much has been written about student-focused models for information search and use, little has been reported on how training for the…

  19. Meaningful Learning in the Teaching of Culture: The Project Based Learning Approach

    Science.gov (United States)

    Kean, Ang Chooi; Kwe, Ngu Moi

    2014-01-01

    This paper reports on a collaborative effort taken by a team of three teacher educators in using the Project Based Learning (PBL) approach in the teaching of Japanese culture with the aim to investigate the presence of actual "meaningful learning" among 15 students of a 12-Week Preparatory Japanese Language course under a teacher…

  20. Planning-in-Action: An Innovative Approach to Human Development. The Hunger Project.

    Science.gov (United States)

    Community Development Journal, 1991

    1991-01-01

    The Hunger Project in India used a strategic planning-in-action approach that involved (1) reaching a common understanding; (2) creating a strategic intent; (3) choosing social indicators; (4) identifying strategic objectives; (5) empowering leadership; (6) identifying immediate action steps; and (7) sustaining the action. (SK)

  1. Implementing the Project Approach: A Case Study of Hybrid Pedagogy in a Hong Kong Kindergarten

    Science.gov (United States)

    Chen, Jennifer J.; Li, Hui; Wang, Jing-ying

    2017-01-01

    The Project Approach has been promoted in Hong Kong kindergartens since the 1990s. However, the dynamic processes and underlying mechanisms involved in the teachers' implementation of this pedagogical method there have not yet been fully investigated. This case study of one typical kindergarten in Hong Kong documented how and why eight teachers…

  2. BlueSky ATC Simulator Project : An Open Data and Open Source Approach

    NARCIS (Netherlands)

    Hoekstra, J.M.; Ellerbroek, J.

    2016-01-01

    To advance ATM research as a science, ATM research results should be made more comparable. A possible way to do this is to share tools and data. This paper presents a project that investigates the feasibility of a fully open-source and open-data approach to air traffic simulation. Here, the first of

  3. Project-Based Learning: A Promising Approach to Improving Student Outcomes. Issue Focus

    Science.gov (United States)

    Quint, Janet; Condliffe, Barbara

    2018-01-01

    The concept of project-based learning (PBL) has garnered wide support among a number of K-12 education policy advocates and funders. PBL is viewed as an approach that enables students to develop the "21st century competencies"--cognitive and socioemotional skills--needed for success in college and careers. This issue focus, pulling from…

  4. Facilitating Work Based Learning Projects: A Business Process Oriented Knowledge Management Approach

    NARCIS (Netherlands)

    Miao, Yongwu; Sloep, Peter; Koper, Rob

    2009-01-01

    Miao, Y., Sloep, P. B., & Koper, R. (2009). Facilitating Work Based Learning Projects: A Business Process Oriented Knowledge Management Approach. Presented at the 'Open workshop of TENCompetence - Rethinking Learning and Employment at a Time of Economic Uncertainty-event'. November, 19, 2009,

  5. Facilitating Work Based Learning Projects: A Business Process Oriented Knowledge Management Approach

    NARCIS (Netherlands)

    Miao, Yongwu; Sloep, Peter; Koper, Rob

    2009-01-01

    Miao, Y., Sloep, P. B., & Koper, R. (2010). Facilitating Work Based Learning Projects: A Business Process Oriented Knowledge Management Approach. In D. Griffiths & R. Koper (Eds.), Rethinking Learning and Employment at a Time of Economic Uncertainty. Proceedings of the 6th TENCompetence Open

  6. Voices from the Field: Developing Employability Skills for Archaeological Students Using a Project Based Learning Approach

    Science.gov (United States)

    Wood, Gaynor

    2016-01-01

    Graduate employment statistics are receiving considerable attention in UK universities. This paper looks at how a wide range of employability attributes can be developed with students, through the innovative use of the Project Based Learning (PjBL) approach. The case study discussed here involves a group of archaeology students from the University…

  7. An Adaptive Approach to Managing Knowledge Development in a Project-Based Learning Environment

    Science.gov (United States)

    Tilchin, Oleg; Kittany, Mohamed

    2016-01-01

    In this paper we propose an adaptive approach to managing the development of students' knowledge in the comprehensive project-based learning (PBL) environment. Subject study is realized by two-stage PBL. It shapes adaptive knowledge management (KM) process and promotes the correct balance between personalized and collaborative learning. The…

  8. A systematic risk management approach employed on the CloudSat project

    Science.gov (United States)

    Basilio, R. R.; Plourde, K. S.; Lam, T.

    2000-01-01

    The CloudSat Project has developed a simplified approach for fault tree analysis and probabilistic risk assessment. A system-level fault tree has been constructed to identify credible fault scenarios and failure modes leading up to a potential failure to meet the nominal mission success criteria.

  9. Methodologic approach for the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.

    Science.gov (United States)

    Namaste, Sorrel Ml; Aaron, Grant J; Varadhan, Ravi; Peerson, Janet M; Suchdev, Parminder S

    2017-07-01

    Background: The Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project is a multiagency and multicountry collaboration that was formed to improve micronutrient assessment and to better characterize anemia. Objectives: The aims of the project were to 1 ) identify factors associated with inflammation, 2 ) assess the relations between inflammation, malaria infection, and biomarkers of iron and vitamin A status and compare adjustment approaches, and 3 ) assess risk factors for anemia in preschool children (PSC) and women of reproductive age (WRA). Design: The BRINDA database inclusion criteria included surveys that 1 ) were conducted after 2004, 2 ) had target groups of PSC, WRA, or both, and 3 ) used a similar laboratory methodology for the measurement of ≥1 biomarker of iron [ferritin or soluble transferrin receptor or vitamin A status (retinol-binding protein or retinol)] and ≥1 biomarker of inflammation (α-1-acid glycoprotein or C-reactive protein). Individual data sets were standardized and merged into a BRINDA database comprising 16 nationally and regionally representative surveys from 14 countries. Collectively, the database covered all 6 WHO geographic regions and contained ∼30,000 PSC and 27,000 WRA. Data were analyzed individually and combined with the use of a meta-analysis. Results: The methods that were used to standardize the BRINDA database and the analytic approaches used to address the project's research questions are presented in this article. Three approaches to adjust micronutrient biomarker concentrations in the presence of inflammation and malaria infection are presented, along with an anemia conceptual framework that guided the BRINDA project's anemia analyses. Conclusions: The BRINDA project refines approaches to interpret iron and vitamin A biomarker values in settings of inflammation and malaria infection and suggests the use of a new regression approach as well as proposes an anemia framework to

  10. A MCDM approach for project finance selection: An application in the renewable energy sector

    Directory of Open Access Journals (Sweden)

    García-Bernabeu, Ana

    2015-05-01

    Full Text Available Renewable energy (RE is emerging as a solution in order to replace fossil fuels and become the primary source of energy consumption. Investments in the RE sector involve huge amounts of capital but also many risks. Public sector plays an important role in promoting RE projects but due to the need for reducing public expenditure the private sector becomes essential in financing this type of projects. Project Finance is widely used in RE projects and is especially attractive to the private sector because it can fund major projects off balance sheet. The objective of this paper is to present a decision making tool for helping the private sector on the selection process of RE projects to be funded. The problem could be considered as a multiple criteria decision-making problem where both, financial and non-financial criteria have to be taken into account. Objective aggregation weights for those criteria are obtained using the Moderate Pessimism Decision Making approach and a final ranking of the projects is obtained.

  11. How should grid operators govern smart grid innovation projects? An embedded case study approach

    International Nuclear Information System (INIS)

    Reuver, Mark de; Lei, Telli van der; Lukszo, Zofia

    2016-01-01

    Grid operators increasingly have to collaborate with other actors in order to realize smart grid innovations. For routine maintenance, grid operators typically acquire technologies in one-off transactions, but the innovative nature of smart grid projects may require more collaborate relationships. This paper studies how a transactional versus relational approach to governing smart grid innovation projects affects incentives for other actors to collaborate. We analyse 34 cases of smart grid innovation projects based on extensive archival data as well as interviews. We find that projects relying on relational governance are more likely to provide incentives for collaboration. Especially non-financial incentives such as reputational benefits and shared intellectual property rights are more likely to be found in projects relying on relational governance. Policy makers that wish to stimulate smart grid innovation projects should consider stimulating long-term relationships between grid operators and third parties, because such relationships are more likely to produce incentives for collaboration. - Highlights: • Smart grids require collaboration between grid operators and other actors. • We contrast transactional and relational governance of smart grid projects. • Long-term relations produce more incentives for smart grid collaboration. • Non-financial incentives are more important in long-term relations. • Policy makers should stimulate long-term relations to stimulate smart grids.

  12. Conflict Approaches of Effective Project Manager in the Upstream Sector of Indonesian Oil & Gas Industry

    Directory of Open Access Journals (Sweden)

    Adhi Cahyono

    2012-11-01

    Full Text Available Normal 0 false false false IN X-NONE AR-SA MicrosoftInternetExplorer4 Conflict can be functional or dysfunctional to the organization’s performance. This study focused on the relationship between conflict approaches implemented by the project manager based on project team member’s perception on the effectiveness of the project manager in managing project’s conflict. Questionnaires were modified from Barker et al. (1988 to measure conflict management approaches and outcomes of managing project conflict. Data were gathered from 57 respondents who worked in the Engineering, Procurement, and Construction (EPC contractors serving the upstream sector of the Oil and Gas industry in Indonesia. By using Pearson correlation, result of this study indicated that project managers were perceived to be effective in managing project conflict when implementing cooperative and confi rmative approaches, but ineffective when combining competitive and avoidance approaches. Further research should investigate correlation between cultural dimensions with conflict approaches and outcomes of managing conflict. Keywords: Conflict approaches, effective project manager, EPC contractors, upstream sector of oil and gas industry /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi; mso-fareast-language:EN-US;}

  13. Reducing Bottlenecks to Improve the Efficiency of the Lung Cancer Care Delivery Process: A Process Engineering Modeling Approach to Patient-Centered Care.

    Science.gov (United States)

    Ju, Feng; Lee, Hyo Kyung; Yu, Xinhua; Faris, Nicholas R; Rugless, Fedoria; Jiang, Shan; Li, Jingshan; Osarogiagbon, Raymond U

    2017-12-01

    The process of lung cancer care from initial lesion detection to treatment is complex, involving multiple steps, each introducing the potential for substantial delays. Identifying the steps with the greatest delays enables a focused effort to improve the timeliness of care-delivery, without sacrificing quality. We retrospectively reviewed clinical events from initial detection, through histologic diagnosis, radiologic and invasive staging, and medical clearance, to surgery for all patients who had an attempted resection of a suspected lung cancer in a community healthcare system. We used a computer process modeling approach to evaluate delays in care delivery, in order to identify potential 'bottlenecks' in waiting time, the reduction of which could produce greater care efficiency. We also conducted 'what-if' analyses to predict the relative impact of simulated changes in the care delivery process to determine the most efficient pathways to surgery. The waiting time between radiologic lesion detection and diagnostic biopsy, and the waiting time from radiologic staging to surgery were the two most critical bottlenecks impeding efficient care delivery (more than 3 times larger compared to reducing other waiting times). Additionally, instituting surgical consultation prior to cardiac consultation for medical clearance and decreasing the waiting time between CT scans and diagnostic biopsies, were potentially the most impactful measures to reduce care delays before surgery. Rigorous computer simulation modeling, using clinical data, can provide useful information to identify areas for improving the efficiency of care delivery by process engineering, for patients who receive surgery for lung cancer.

  14. Applicability of the "Frame of Reference" approach for environmental monitoring of offshore renewable energy projects.

    Science.gov (United States)

    Garel, Erwan; Rey, Cibran Camba; Ferreira, Oscar; van Koningsveld, Mark

    2014-08-01

    This paper assesses the applicability of the Frame of Reference (FoR) approach for the environmental monitoring of large-scale offshore Marine Renewable Energy (MRE) projects. The focus is on projects harvesting energy from winds, waves and currents. Environmental concerns induced by MRE projects are reported based on a classification scheme identifying stressors, receptors, effects and impacts. Although the potential effects of stressors on most receptors are identified, there are large knowledge gaps regarding the corresponding (positive and negative) impacts. In that context, the development of offshore MRE requires the implementation of fit-for-purpose monitoring activities aimed at environmental protection and knowledge development. Taking European legislation as an example, it is suggested to adopt standardized monitoring protocols for the enhanced usage and utility of environmental indicators. Towards this objective, the use of the FoR approach is advocated since it provides guidance for the definition and use of coherent set of environmental state indicators. After a description of this framework, various examples of applications are provided considering a virtual MRE project located in European waters. Finally, some conclusions and recommendations are provided for the successful implementation of the FoR approach and for future studies. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. SU-F-T-592: A Delivery QA-Free Approach for Adaptive Therapy of Prostate Cancer with Static Intensity Modulated Radiotherapy

    International Nuclear Information System (INIS)

    Roth, T; Dooley, J; Zhu, T; Woods, R; Mavroidis, P; Lian, J

    2016-01-01

    Purpose: Clinical implementations of adaptive radiotherapy (ART) are limited mainly by the requirement of delivery QA (DQA) prior to the treatment. Small segment size and small segment MU are two dominant factors causing failures of DQA. The aim of this project is to explore the feasibility of ART treatment without DQA by using a partial optimization approach. Methods: A retrospective simulation study was performed on two prostate cancer patients treated with SMLC-IMRT. The prescription was 180cGx25 fractions with daily CT-on-rail imaging for target alignment. For each patient, seven daily CTs were selected randomly across treatment course. The contours were deformablely transferred from the simulation CT onto the daily CTs and modified appropriately. For each selected treatment, dose distributions from original beams were calculated on the daily treatment CTs (DCT plan). An ART plan was also created by optimizing the segmental MU only, while the segment shapes were preserved and the minimum MU constraint was respected. The overlaps, between PTV and the rectum, between PTV and the bladder, were normalized by the PTV volume. This ratio was used to characterize the difficulty of organs-at-risk (OAR) sparing. Results: Comparing to the original plan, PTV coverage was compromised significantly in DCT plans (82% ± 7%) while all ART plans preserved PTV coverage. ART plans showed similar OAR sparing as the original plan, such as V40Gy=11.2cc (ART) vs 11.4cc (original) for the rectum and D10cc=4580cGy vs 4605cGy for the bladder. The sparing of the rectum/bladder depends on overlap ratios. The sparing in ART was either similar or improved when overlap ratios in treatment CTs were smaller than those in original plan. Conclusion: A partial optimization method is developed that may make the real-time ART feasible on selected patients. Future research is warranted to quantify the applicability of the proposed method.

  16. Transition of a traditional pharmacology course for dental students to an online delivery format: a pilot project.

    Science.gov (United States)

    Gadbury-Amyot, Cynthia C; Brockman, William G

    2011-05-01

    The purpose of this report is to describe the rationale and subsequent transition of a pharmacology course for dental students from a traditional face-to-face lecture format to online delivery using a course management system (CMS). A dental school faculty member with dental and pharmacology degrees and a Ph.D. was asked to serve as course director and to develop and implement a nontraditional course using the Blackboard CMS technology, which houses asynchronous course content materials, study guides, and online resource materials. Respondus software was used to create, manage, and administer weekly online quizzes. A comprehensive midterm and final examination were conducted in a traditional face-to-face setting. A survey was used to capture student satisfaction with this self-directed introductory pharmacology course. Participants were second-year dental students (Classes of 2011 and 2012). There was a survey response rate of 91 percent (179/197). The Likert-style survey questions produced ordinal data from which the median and interquartile range were calculated. On a scale in which 1=Poor, 5=Excellent, the median evaluation for the instructor was 4 (IQR=1.5). On a global question that asked how students rate the course overall, the median score was 4 (IQR=1.0). Results show that a majority of students were positive about the online delivery of the introductory pharmacology course and for many students this was their first online course experience. Resistance to self-directed learning was a theme with those students who rated the course poorly. In a comparison of overall course grades from the previous year, student performance in this course was much stronger. As a result of student feedback seeking more interaction with the course director, it was determined that the next time the course is offered there will be additional opportunities for greater face-to-face time with the instructor. Ongoing evaluation will be important as new teaching technologies emerge

  17. Project-Based Approach in a First-Year Engineering Course to Promote Project Management and Sustainability

    Directory of Open Access Journals (Sweden)

    Pooya Taheri

    2018-05-01

    Full Text Available To safeguard the environment and satisfy the energy needs of the present, without compromising the ability of future generations to do the same, sustainable energy development is urgently needed. This complex task is riddled with social, political, scientific, technical, and environmental challenges. Education is essential if we are to meet the energy demands of the world in the most sustainable manner available to us. Langara College offers a first-year engineering course that is meant to introduce students to engineering design and case studies, in addition to providing a brief glance on the history, ethics, and the different disciplines of engineering (APSC 1010. Using a project-based learning approach that promotes teamwork and research, this course uses a variety of instructional methods including lectures, class discussions, and guest appearances by experts in their fields. Introductions to technical concepts, such as soldering, 3D printing, and microcontroller, are also addressed in this course. This paper demonstrates how this, or similar courses, are optimized to raise awareness of the sustainability issues this planet is facing. Learning outcomes are evaluated using an anonymous student survey which demonstrates how the students’ project-management and presentation skills have improved.

  18. RIBA Project - Risk-Informed approach for In-Service Inspection of Nuclear Power Plant Components. Project summary

    International Nuclear Information System (INIS)

    Lidbury, D.; Smith, G.

    2001-12-01

    The need for a European review of a Risk-Informed Approach for In-Service Inspection of Nuclear Power Plant Components (RIBA) was identified in 1998. This was as a priority item in the programme of activities conducted in the framework of the Council Resolutions of 22 July 1975 and of 18 June 1992 on the Technological Problems of Nuclear Safety. The RIBA Project was established in November 1999 as a 24-month Study Contract funded by the European Commission within the frame of the former DG XI WGCS (Working Group on Codes and Standards). The Study Contract was subsequently managed for the EC by DG TREN. The participants in RIBA were Serco Assurance (project coordinator), Ringhals AB, EDF, Tecnatom SA and Westinghouse Electric Europe. The work is presented in a summary report with the detailed results contained in three companion reports as follows: main conclusions and recommendations, Review of Existing Risk-Informed Methodologies, A Comparative Study of Risk-Informed In-Service Inspection Applications, Conclusions and Recommendations for Risk-Informed in-service inspection methodology applied to Nuclear Power Plants in Europe. (author)

  19. A process dissociation approach to objective-projective test score interrelationships.

    Science.gov (United States)

    Bornstein, Robert F

    2002-02-01

    Even when self-report and projective measures of a given trait or motive both predict theoretically related features of behavior, scores on the 2 tests correlate modestly with each other. This article describes a process dissociation framework for personality assessment, derived from research on implicit memory and learning, which can resolve these ostensibly conflicting results. Research on interpersonal dependency is used to illustrate 3 key steps in the process dissociation approach: (a) converging behavioral predictions, (b) modest test score intercorrelations, and (c) delineation of variables that differentially affect self-report and projective test scores. Implications of the process dissociation framework for personality assessment and test development are discussed.

  20. Taking Libraries’ Cultural Content to the User – Approaches and Experiences from the EEXCESS Project

    Directory of Open Access Journals (Sweden)

    Timo Borst

    2016-09-01

    Full Text Available Before the advent of the internet users had to physically visit libraries and other cultural institutions in order to search, find and access content. With the emergence and massive use of the World Wide Web and associated tools and technologies this situation has changed drastically. If content is to be found and used, it must be present where users do their daily digital work. The aim of the EU project EEXCESS (http://eexcess.eu/ is to inject the content into the working environments of the users. In this paper, we show some of the approaches, use cases and technical implementations we developed in the project.

  1. The Human Genome Project and the social contract: a law policy approach.

    Science.gov (United States)

    Byk, C

    1992-08-01

    For the first time in history, genetics will enable science to completely identify each human as genetically unique. Will this knowledge reinforce the trend for more individual liberties or will it create a 'brave new world'? A law policy approach to the problems raised by the human genome project shows how far our democratic institutions are from being the proper forum to discuss such issues. Because of the fears and anxiety raised in the population, and also because of its wide implications on the everyday life, the human genome analysis more than any other project needs to succeed in setting up such a social assessment.

  2. Interprofessional primary care protocols: a strategy to promote an evidence-based approach to teamwork and the delivery of care.

    Science.gov (United States)

    Goldman, Joanne; Meuser, Jamie; Lawrie, Lynne; Rogers, Jess; Reeves, Scott

    2010-11-01

    Primary care reform involving interprofessional team-based care is a global phenomenon. In Ontario, Canada, 150 Family Health Teams (FHTs) have been approved in the past few years. The transition to a FHT is complex involving many changes and the processes for collaborative teamwork are not clearly delineated. To support the transition to team-based care in FHTs, a project was undertaken to develop and implement a series of interprofessional protocols in four clinical areas. These interprofessional protocols would contain relevant and evidence-based resources to support both a team and evidence-based approach to care. This paper reports on a qualitative study to examine the process of interprofessional protocol development and pilot implementation. Adopting an exploratory case study approach (Robson, 2002 ), 36 interviews were conducted with health professionals and community group members who participated in the creation and piloting of the protocols, and with project managers. In addition, observational and documentary data were gathered on the protocol development and implementation processes. The findings from the protocol development stage demonstrate the value of the focus on evidence and team, the process of assessing and targeting FHT needs, inter-organizational and interprofessional sharing, the importance of facilitation and support, and expectations for implementation. The findings from the pilot implementation stage report on the importance of champions and leaders, the implementation strategies used, FHT and organizational factors affecting implementation, and outcomes achieved. Findings are discussed in relation to the knowledge translation and interprofessional literature. Research is ongoing to examine the effectiveness of dissemination of the protocols to FHTs across the province of Ontario and its impact on health care outcomes.

  3. Fuzzy logic approach for energetic and economic evaluation of hydroelectric projects

    International Nuclear Information System (INIS)

    Iliev, Atanas M.

    2003-01-01

    A mathematical model for energetic and economic evaluation of hydroelectric projects is developed. The main advantage of the proposed methodology is that the model considers uncertainty and vagueness which appears during the decision making process. Due to modeling of variables that are non statistical in their character, fuzzy logic approach is fully incorporated in the model. The first step in energetic evaluation of the hydro power projects is determination of the characteristic of the efficiency of the units to be installed in hydro power plants. For this purpose the model which uses the best characteristics of Artificial Network Fuzzy Inference System (ANFIS) is applied. The method is tested on real systems: HPP Tikves- the power plant in operation and HPP Kozjak - the power plant in construction. The results obtained from practical implementation show that the proposed approach gives superior results than classical polynomial approximation. The model for determining the consumption characteristic of hydro power plant is developed by Sugeno Fuzzy Logic System with polynomials in the consequent part of the rules. Model takes into account the variable gross head of HPP, as well as, the number of units which will be in operation for given output. Modeling of the gross head and power output are performed by expert's design membership functions. This model is practically applied on HPP Tikves for determination of the consumption characteristic for several gross head. The plausible yearly production of electricity from hydro power project, which is important for estimation of the benefit from the project, is calculated by mixed fuzzy-statistical model. hi this approach fuzzy set of the inflow is constructed according to the statistical parameters. The calculation of the production of electricity is realized for a several hydrological conditions which are described by linguistic variables. Finally, Mamdani Fuzzy Inference System with fuzzy number in consequent part

  4. Collaborative Engagement Approaches For Delivering Sustainable Infrastructure Projects In The AEC Sector

    Directory of Open Access Journals (Sweden)

    Adetola, Alaba

    2011-12-01

    Full Text Available The public sector has traditionally financed and operated infrastructure projects using resources from taxes and various levies (e.g. fuel taxes, road user charges. However, the rapid increase in human population growth coupled with extended globalisation complexities and associated social/political/economic challenges have placed new demands on the purveyors and operators of infrastructure projects. The importance of delivering quality infrastructure has been underlined by the United Nations declaration of the Millennium Development Goals; as has the provision of ‘adequate’ basic structures and facilities necessary for the well-being of urban populations in developing countries. Thus, in an effort to finance developing countries’ infrastructure needs, most countries have adopted some form of public-private collaboration strategy. This paper critically reviews these collaborative engagement approaches, identifies and highlights 10 critical themes that need to be appropriately captured and aligned to existing business models in order to successfully deliver sustainable infrastructure projects. Research findings show that infrastructure services can be delivered in many ways, and through various routes. For example, a purely public approach can cause problems such as slow and ineffective decision-making, inefficient organisational and institutional augmentation, and lack of competition and inefficiency (collectively known as government failure. On the other hand, adopting a purely private approach can cause problems such as inequalities in the distribution of infrastructure services (known as market failure. Thus, to overcome both government and market failures, a collaborative approach is advocated which incorporates the strengths of both of these polarised positions.

  5. AN APPROACH TO MANAGING UNIVERSITY STUDENTS’ SELF-STUDY BASED ON INTERDISCIPLINARY E-PROJECTS

    Directory of Open Access Journals (Sweden)

    Yu. V. Krasavina

    2017-01-01

    Full Text Available Introduction. There are two tendencies considerably allocated in educational process of the modern higher school: the increasing amount of time for independent work of students and the active introduction of the information and communication technologies (ICT which is followed by its continuous updating and improvement. The article contributes to the problem of managing competency-based and professionally-oriented self-study for future teachers; the suggested method combines the advantages of project-based learning and the use of ICT.Aim. The objective of the paper is to assess the efficacy of interdisciplinary e-project-based approach to managing university students’ self-study.Methods. To evaluate the efficacy of such innovative method as interdisciplinary e-projects, we use quantitative and qualitative assessment. A set of quantitative pre- and post-surveys are administered for students in order to evaluate their learning outcomes and competencies development. Students’ motivation and attitudes were evaluated through questionnaires, interviews and discussions. An expert group appraisal method was used to define assessment components. Results. The groups of didactic properties and ICT didactic functions are allocated and analysed. Types of educational projects are presented. Definition and characteristic of the interdisciplinary e-project are given. Results of the pedagogical experiment conducted in M. T. Kalashnikov Izhevsk State University are described; the technology of development among students of foreign-language and information-communication competences as the most important professional ones is approved.Scientific novelty. The method of interdisciplinary e-projects is offered; it involves a set of the educational-informative techniques and procedures realized in the electronic environment and directed to the solution of the interdisciplinary problem connected with types and tasks of vocational activity

  6. An Approach to Tailoring Major Technical Reviews Based on Project Characteristics and Stakeholder Interests

    Science.gov (United States)

    Richstein, Alan B.; Nolte, Jerome T.; Pfarr, Barbara B.

    2004-01-01

    There are numerous technical reviews that occur throughout the systems engineering process life cycle. Many are well known by project managers and stakeholders such as developers and end users, an example of much is the critical design review (CDR). This major milestone for a large, complex new project may last two or more days, include an extensive agenda of topics, and entail hundreds of hours of developer time to prepare presentation materials and associated documents. Additionally, the weeks of schedule spent on review preparation is at least partly at the expense of other work. This paper suggests an approach for tailoring technical reviews, based on the project characteristics and the project manager s identification of the key stakeholders and understanding of their most important issues and considerations. With this insight the project manager can communicate to, manage expectations oc and establish formal agreement with the stakeholders as to which reviews, and at what depth, are most appropriate to achieve project success. The authors, coming from diverse organizations and backgrounds, have drawn on their personal experiences and summarized the best practices of their own organizations to create a common framework to provide guidance on the adaptation of design reviews to other system engineers.

  7. The Use of Social Media and Mobile applications in content delivery for the MY NASA DATA and SCOOL Projects in support of Education and Outreach Initiatives

    Science.gov (United States)

    Lewis, P. M.; Oostra, D.; Moore, S. W.; Crecelius, S. A.

    2011-12-01

    MND project. This brings in the need for the proper selection of a social media tool that is age-appropriate for the students, should they choose to participate. As with the MND project, there has been proper utilization of social media through careful selection and monitoring of the associated metrics. The NASA CERES S'COOL project utilizes YouTube, Flickr, and is also included in the Observe Your World blog to reach out to current and perspective participants. Through the utilization of social media tools, the MY NASA DATA and S'COOL projects are able to keep the participating audiences involved and informed. In general, the use of Web 2.0 and mobile applications has allowed the projects to keep participants engaged in and up-to-date with current information. With the planned implementation of mobile applications to assist in content delivery and data submission, participants will have a mobile, easy to utilize source of scientific data and information. By monitoring current media tools metrics, we are able to monitor use and ingestion of information. The use of such tools and metrics allows us to better serve our target audience and shift focus, if needed, to the most up-to-date and popular social media tools.

  8. Introduction to the Biomass Project: An Illustration of Evidence-Centered Assessment Design and Delivery Capability. CSE Report.

    Science.gov (United States)

    Steinberg, Linda S.; Mislevy, Robert J.; Almond, Russell G.; Baird, Andrew B.; Cahallan, Cara; Dibello, Louis V.; Senturk, Deniz; Yan, Duanli; Chernick, Howard; Kindfield, Ann C. H.

    This paper describes the design rationale for a prototype of an innovative assessment product, and the process that led to the design. The goals of the Biomass project were to demonstrate: (1) an assessment product designed to serve two new purposes in the transition from high school to college; and (2) the capability needed to produce this kind…

  9. Report on the bill project related to the struggle against proliferation of weapons of mass destruction and their delivery systems

    International Nuclear Information System (INIS)

    2010-01-01

    In a first part presenting the various forms of proliferations, the author first gives a quantitative overview of illegal activities concerning nuclear materials, and then discusses the existence and activities of proliferation networks, explaining how international trade liberalization creates a favourable context for proliferations of any kind, and describing how a typical network is organised. He also discusses the example of Iraq and the case of the network created by the Pakistani scientist Abdul Q. Khan. The risk created by the hypothetical relationship between terrorism and nuclear weapon of mass destruction is also questioned. Then, after having recalled the existing international texts and the present national legislation, the author comments the contribution on the bill project and outlines aspects which are not dealt with by this bill project: radiological devices and cybernetic attacks. Then he reports the comments made by the commission on the bill project articles which define interdictions, sanctions and sentences, or procedures against people or organisations involved in the financing or the use of weapons of mass destruction (biological and chemical). A table gives a comparison between the bill project text and the commission's propositions

  10. The Accumulating Data to Optimally Predict Obesity Treatment (ADOPT) Core Measures Project: Rationale and Approach.

    Science.gov (United States)

    MacLean, Paul S; Rothman, Alexander J; Nicastro, Holly L; Czajkowski, Susan M; Agurs-Collins, Tanya; Rice, Elise L; Courcoulas, Anita P; Ryan, Donna H; Bessesen, Daniel H; Loria, Catherine M

    2018-04-01

    Individual variability in response to multiple modalities of obesity treatment is well documented, yet our understanding of why some individuals respond while others do not is limited. The etiology of this variability is multifactorial; however, at present, we lack a comprehensive evidence base to identify which factors or combination of factors influence treatment response. This paper provides an overview and rationale of the Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures Project, which aims to advance the understanding of individual variability in response to adult obesity treatment. This project provides an integrated model for how factors in the behavioral, biological, environmental, and psychosocial domains may influence obesity treatment responses and identify a core set of measures to be used consistently across adult weight-loss trials. This paper provides the foundation for four companion papers that describe the core measures in detail. The accumulation of data on factors across the four ADOPT domains can inform the design and delivery of effective, tailored obesity treatments. ADOPT provides a framework for how obesity researchers can collectively generate this evidence base and is a first step in an ongoing process that can be refined as the science advances. © 2018 The Obesity Society.

  11. Identifying and prioritizing barriers to implementation of smart energy city projects in Europe: An empirical approach

    International Nuclear Information System (INIS)

    Mosannenzadeh, Farnaz; Di Nucci, Maria Rosaria; Vettorato, Daniele

    2017-01-01

    Successful implementation of smart energy city projects in Europe is crucial for a sustainable transition of urban energy systems and the improvement of quality of life for citizens. We aim to develop a systematic classification and analysis of the barriers hindering successful implementation of smart energy city projects. Through an empirical approach, we investigated 43 communities implementing smart and sustainable energy city projects under the Sixth and Seventh Framework Programmes of the European Union. Validated through literature review, we identified 35 barriers categorized in policy, administrative, legal, financial, market, environmental, technical, social, and information-and-awareness dimensions. We prioritized these barriers, using a novel multi-dimensional methodology that simultaneously analyses barriers based on frequency, level of impact, causal relationship among barriers, origin, and scale. The results indicate that the key barriers are lacking or fragmented political support on the long term at the policy level, and lack of good cooperation and acceptance among project partners, insufficient external financial support, lack of skilled and trained personnel, and fragmented ownership at the project level. The outcome of the research should aid policy-makers to better understand and prioritize implementation barriers to develop effective action and policy interventions towards more successful implementation of smart energy city projects. - Highlights: • A solid empirical study on the implementation of European smart energy city projects. • We found 35 barriers in nine dimensions; e.g. policy, legal, financial, and social. • We suggested a new multi-dimensional methodology to prioritize barriers. • Lacking or fragmented political support on the long term is a key barrier. • We provided insights for action for project coordinators and policy makers.

  12. Symmetry-projected variational approach to the one-dimensional Hubbard model

    International Nuclear Information System (INIS)

    Schmid, K.W.; Dahm, T.; Margueron, J.; Muether, H.

    2005-01-01

    We apply a variational method devised for the nuclear many-body problem to the one-dimensional Hubbard model with nearest neighbor hopping and periodic boundary conditions. The test wave function consist for each state out of a single Hartree-Fock determinant mixing all the sites (or momenta) as well as the spin projections of the electrons. Total spin and linear momentum are restored by projection methods before the variation. It is demonstrated that this approach reproduces the results of exact diagonalizations for half-filled N=12 and N=14 lattices not only for the energies and occupation numbers of the ground but also of the lowest excited states rather well. Furthermore, a system of ten electrons in an N=12 lattice is investigated and, finally, an N=30 lattice is studied. In addition to energies and occupation numbers we present the spectral functions computed with the help of the symmetry-projected wave functions as well

  13. Taking a 'Big Data' approach to data quality in a citizen science project.

    Science.gov (United States)

    Kelling, Steve; Fink, Daniel; La Sorte, Frank A; Johnston, Alison; Bruns, Nicholas E; Hochachka, Wesley M

    2015-11-01

    Data from well-designed experiments provide the strongest evidence of causation in biodiversity studies. However, for many species the collection of these data is not scalable to the spatial and temporal extents required to understand patterns at the population level. Only data collected from citizen science projects can gather sufficient quantities of data, but data collected from volunteers are inherently noisy and heterogeneous. Here we describe a 'Big Data' approach to improve the data quality in eBird, a global citizen science project that gathers bird observations. First, eBird's data submission design ensures that all data meet high standards of completeness and accuracy. Second, we take a 'sensor calibration' approach to measure individual variation in eBird participant's ability to detect and identify birds. Third, we use species distribution models to fill in data gaps. Finally, we provide examples of novel analyses exploring population-level patterns in bird distributions.

  14. Economic evaluation of environmental impacts of open cast mining project - an approach

    International Nuclear Information System (INIS)

    Maiti, S.K.; Pathak, K.

    1998-01-01

    Economic valuation of environmental attributes are pragmatic approach to evaluating the impacts and it helps decision makers to arrive at objective decisions on the basis of cost benefit ratio. For determining the physical impact and its quantification, four evaluation methods, namely-market price method, surrogate market price, survey based and cost based approaches are generally used. The present paper reviews the importance of environmental evaluation of impacts of mining and also reviews a few suitable methodologies that could be effectively used for economic evaluation of environmental impacts in open cast mining projects. (author)

  15. A Systematic Mapping on Supporting Approaches for Requirements Traceability in the Context of Software Projects

    Directory of Open Access Journals (Sweden)

    MALCHER, P R.C.

    2015-12-01

    Full Text Available The Requirements Traceability is seen as a quality factor with regard to software development, being present in standards and quality models. In this context, several techniques, models, frameworks and tools have been used to support it. Thus, the purpose of this paper is to present a systematic mapping carried out in order to find in the literature approaches to support the requirements traceability in the context of software projects and make the categorization of the data found in order to demonstrate, by means of a reliable, accurate and auditable method, how this area has developed and what are the main approaches are used to implement it.

  16. NextGEOSS project: A user-driven approach to build a Earth Observations Data Hub

    Science.gov (United States)

    Percivall, G.; Voidrot, M. F.; Bye, B. L.; De Lathouwer, B.; Catarino, N.; Concalves, P.; Kraft, C.; Grosso, N.; Meyer-Arnek, J.; Mueller, A.; Goor, E.

    2017-12-01

    Several initiatives and projects contribute to support Group on Earth Observation's (GEO) global priorities including support to the UN 2030 Agenda for sustainable development, the Paris Agreement on climate change, and the Sendai Framework for Disaster Risk Reduction . Running until 2020, the NextGEOSS project evolves the European vision of a user driven GEOSS data exploitation for innovation and business, relying on the three main pillars: engaging communities of practice delivering technological advancements advocating the use of GEOSS These 3 pillars support the creation and deployment of Earth observation based innovative research activities and commercial services. In this presentation we will emphasise how the NextGEOSS project uses a pilot-driven approach to ramp up and consolidate the system in a pragmatique way, integrating the complexity of the existing global ecosystem, leveraging previous investments, adding new cloud technologies and resources and engaging the diverse communities to address all types of Sustainable Development Goals (SDGs). A set of 10 initial pilots have been defined by the project partners to address the main challenges and include as soon as possible contributions to SDGs associated with Food Sustainability, Bio Diversity, Space and Security, Cold Regions, Air Pollutions, Disaster Risk Reduction, Territorial Planning, Energy. In 2018 and 2019 the project team will work on two new series of Architecture Implementation Pilots (AIP-10 and AIP-11), opened world-wide, to increase discoverability, accessibility and usability of data with a strong User Centric approach for innovative GEOSS powered applications for multiple societal areas. All initiatives with an interest in and need of Earth observations (data, processes, models, ...) are welcome to participate to these pilots initiatives. NextGEOSS is a H2020 Research and Development Project from the European Community under grant agreement 730329.

  17. Delivery presentations

    Science.gov (United States)

    Pregnancy - delivery presentation; Labor - delivery presentation; Occiput posterior; Occiput anterior; Brow presentation ... The mother can walk, rock, and try different delivery positions during labor to help encourage the baby ...

  18. Comment on "Fringe projection profilometry with nonparallel illumination: a least-squares approach"

    Science.gov (United States)

    Wang, Zhaoyang; Bi, Hongbo

    2006-07-01

    We comment on the recent Letter by Chen and Quan [Opt. Lett.30, 2101 (2005)] in which a least-squares approach was proposed to cope with the nonparallel illumination in fringe projection profilometry. It is noted that the previous mathematical derivations of the fringe pitch and carrier phase functions on the reference plane were incorrect. In addition, we suggest that the variation of carrier phase along the vertical direction should be considered.

  19. Facilitating Work Based Learning Projects: A Business Process Oriented Knowledge Management Approach

    OpenAIRE

    Miao, Yongwu; Sloep, Peter; Koper, Rob

    2009-01-01

    Miao, Y., Sloep, P. B., & Koper, R. (2010). Facilitating Work Based Learning Projects: A Business Process Oriented Knowledge Management Approach. In D. Griffiths & R. Koper (Eds.), Rethinking Learning and Employment at a Time of Economic Uncertainty. Proceedings of the 6th TENCompetence Open workshop (pp. 22-33). November, 19-20, 2009, Manchester, UK. Bolton, UK: Institute for Educational Cybernetics, The University of Bolton. For the complete book please see http://hdl.handle.net/1820/3191

  20. The Palouse Basin Participatory Model Pilot Project: A Participatory Approach to Bi-state Groundwater Management

    Science.gov (United States)

    Beall, A.; Fiedler, F.; Boll, J.; Cosens, B.; Harris, C.

    2008-12-01

    In March 2008, The University of Idaho Waters of the West, the Palouse Basin Aquifer Committee and its Citizen Advisory Group undertook a pilot project to explore the use of participatory modeling to assist with water resource management decisions. The Palouse basin supplies Moscow, Idaho, Pullman, Washington, and surrounding communities with high quality groundwater. However, water levels in the major aquifer systems have been declining since records have been kept. Solutions are complicated by jurisdictional considerations and limited alternatives for supply. We hope that by using a participatory approach major conflicts will be avoided. Group system dynamics modeling has been used for various environmental concerns such as air quality, biological management, water quality and quantity. These models create a nexus of science, policy, and economic and social concerns, which enhances discussion of issues surrounding the use of natural resources. Models may be developed into educational and or decision support tools which can be used to assist with planning processes. The long-term goal of the Palouse basin project is to develop such a model. The pilot project participants include hydrologists, facility operators, policy makers and local citizens. The model they have developed integrates issues such as scientific uncertainty, groundwater volumes, and potential conservation measures and costs. Preliminary results indicate that participants are satisfied with the approach and are looking to use the model for education and to help direct potential research. We will present the results of the pilot project, including the developed model and insights from the process.

  1. UAV Delivery Monitoring System

    Directory of Open Access Journals (Sweden)

    San Khin Thida

    2018-01-01

    Full Text Available UAV-based delivery systems are increasingly being used in the logistics field, particularly to achieve faster last-mile delivery. This study develops a UAV delivery system that manages delivery order assignments, autonomous flight operation, real time control for UAV flights, and delivery status tracking. To manage the delivery item assignments, we apply the concurrent scheduler approach with a genetic algorithm. The present paper describes real time flight data based on a micro air vehicle communication protocol (MAVLink. It also presents the detailed hardware components used for the field tests. Finally, we provide UAV component analysis to choose the suitable components for delivery in terms of battery capacity, flight time, payload weight and motor thrust ratio.

  2. A Project Approach to Teaching Aquaculture and Entrepreneurial Skills in the Cage Culture of Salmonids Program at the Marine Institute.

    Science.gov (United States)

    Churchill, Edgar; Smith, Boyd

    Between September and December 1986, the Marine Institute in Newfoundland, Canada, used a "projects approach" to train aquaculture workers for 10 new salmon farms to be opened in spring 1987 by a producers' cooperative. The projects approach combined instruction in the aquaculture skills needed to operate a salmon farm and the entrepreneurial…

  3. A Project-Based Learning Approach to Teaching Physics for Pre-Service Elementary School Teacher Education Students

    Science.gov (United States)

    Goldstein, Olzan

    2016-01-01

    This paper describes the impact of the project-based learning (PBL) approach on learning and teaching physics from the perspective of pre-service elementary school teacher education students and an instructor. This approach promoted meaningful learning (mainly in the scope of projects), higher motivation, and active involvement of students in…

  4. Distinct solutions of infinite U Hubbard model through nested Bethe ansatz and Gutzwiller projection operator approach

    International Nuclear Information System (INIS)

    Mishra, A.K.; Kishore, R.

    2009-01-01

    The exact nested Bethe ansatz solution for the one dimensional (1-D) U infinity Hubbard model show that the state vectors are a product of spin-less fermion and spin wavefunctions, or an appropriate superposition of such factorized wavefunctions. The spin-less fermion component of the wavefunctions ensures no double occupancy at any site. It had been demonstrated that the nested Bethe ansatz wavefunctions in the U infinity limit obey orthofermi statistics. Gutzwiller projection operator formalism is the another well known technique employed to handle U infinity Hubbard model. In general, this approach does not lead to spin-less fermion wavefunctions. Therefore, the nested Bethe ansatz and Gutzwiller projection operator approach give rise to different kinds of the wavefunctions for the U infinity limit of 1-D Hubbard Hamiltonian. To compare the consequences of this dissimilarity in the wavefunctions, we have obtained the ground state energy of a finite system consisting of three particles on a four site closed chain. It is shown that in the nested Bethe ansatz implemented through orthofermion algebra, all the permissible 2 3 spin configurations are degenerate in the ground state. This eight fold degeneracy of the ground state is absent in the Gutzwiller projection operator approach. This finding becomes relevant in the context of known exact U infinity results, which require that all the energy levels are 2 N -fold degenerate for an N particle system.

  5. RGMDV: An approach to requirements gathering and the management of data virtualization projects

    Science.gov (United States)

    Mousa, Ayad Hameed; Shiratuddin, Norshuhada; Bakar, Muhamad Shahbani Abu

    2015-12-01

    Data virtualization (DV) refers to a set of data stores that enable users to query, access, and manipulate data in a unified, abstracted, and encapsulated manner regardless of data location. Apart from reducing data movement, this system provides a unified, abstracted, real-time, and encapsulated view of information for query purposes. Through its provision of live, virtual data in a timely manner, the DV technique can overcome the obstacles faced by organizations and companies as a result of using other data integration techniques. The systematic planning for the period that precedes DV deployment enables organizations to avoid many challenges related to manageability, usability, data quality, and performance. DV requirements are among the most significant and challenging aspects of a DV project. In this study, an approach has been developed to gather and manage the requirements of a DV design model as an initial step in developing such projects. Expert methods are reviewed to validate and evaluate the proposed approach in terms of usability and related components; the results of this review demonstrate that the applied approaches benefit DV development projects.

  6. Ethical issues in cesarean delivery.

    Science.gov (United States)

    Chervenak, Frank A; McCullough, Laurence B

    2017-08-01

    Cesarean delivery is the most common and important surgical intervention in obstetric practice. Ethics provides essential guidance to obstetricians for offering, recommending, recommending against, and performing cesarean delivery. This chapter provides an ethical framework based on the professional responsibility model of obstetric ethics. This framework is then used to address two especially ethically challenging clinical topics in cesarean delivery: patient-choice cesarean delivery and trial of labor after cesarean delivery. This chapter emphasizes a preventive ethics approach, designed to prevent ethical conflict in clinical practice. To achieve this goal, a preventive ethics approach uses the informed consent process to offer cesarean delivery as a medically reasonable alternative to vaginal delivery, to recommend cesarean delivery, and to recommend against cesarean delivery. The limited role of shared decision making is also described. The professional responsibility model of obstetric ethics guides this multi-faceted preventive ethics approach. Copyright © 2017. Published by Elsevier Ltd.

  7. METHODICAL APPROACHES TO ASSESSMENT OF EFFICIENCY OF INVESTMENT PROJECTS OF DEVELOPMENT OF RURAL TERRITORIES

    Directory of Open Access Journals (Sweden)

    Nadejda Shatsilo

    2018-05-01

    Full Text Available The purpose is to justify the principles of assessing the effectiveness of innovation and investment projects of rural areas development on the basis of sustainability. Research methodology. In the course of the research general scientific and special methods for solving the tasks and obtaining the corresponding results were used, in particular: the method of logical analysis - in determining the factors of influence on the efficiency of investment projects; Systematization and generalization - in the synthesis of modern methodological approaches to the evaluation of innovation and investment projects of rural areas development; Abstract-logical - for theoretical generalizations and formulation of the findings of the study. Results.The principles of estimation of efficiency of innovative-investment projects are generalized. The interrelation and interdependence of goals and tasks in the development of three subsystems of sustainability have been studied, which need to be taken into account when identifying the effects arising from the implementation of investment projects. The methodological principles of evaluation of innovation-investment projects of rural areas development in conditions of observance of the requirements of sustainable development are highlighted. The deterrent factors hindering the implementation of the processes of investment of investment resources in the development of rural areas are determined. The principles of implementation of investment projects oriented on sustainable development are substantiated. Priority directions of investing resources investment in the development of rural areas on the principles of sustainability within the framework of solving economic, social and environmental problems have been identified. The mechanism of estimation of efficiency of innovative-investment project of development of rural territory in the conditions of limited financial resources is offered. It is substantiated that it is

  8. A Probabilistic Alternative Approach to Optimal Project Profitability Based on the Value-at-Risk

    Directory of Open Access Journals (Sweden)

    Yonggu Kim

    2018-03-01

    Full Text Available This paper focuses on an investment decision-making process for sustainable development based on the profitability impact factors for overseas projects. Investors prefer to use the discounted cash-flow method. Although this method is simple and straightforward, its critical weakness is its inability to reflect the factor volatility associated with the project evaluation. To overcome this weakness, the Value-at-Risk method is used to apply the volatility of the profitability impact factors, thereby reflecting the risks and establishing decision-making criteria for risk-averse investors. Risk-averse investors can lose relatively acceptable investment opportunities to risk-neutral or risk-amenable investors due to strict investment decision-making criteria. To overcome this problem, critical factors are selected through a Monte Carlo simulation and a sensitivity analysis, and solutions to the critical-factor problems are then found by using the Theory of Inventive Problem Solving and a business version of the Project Definition Rating Index. This study examines the process of recovering investment opportunities with projects that are investment feasible and that have been rejected when applying the criterion of the Value-at-Risk method. To do this, a probabilistic alternative approach is taken. To validate this methodology, the proposed framework for an improved decision-making process is demonstrated using two actual overseas projects of a Korean steel-making company.

  9. Integrated evaluation framework. Based on the logical framework approach for project cycle management

    International Nuclear Information System (INIS)

    1996-11-01

    This Integrated Evaluation Framework (IEF) was developed by TC Evaluation with the aim of presenting in a comprehensive manner the logic of thinking used when evaluating projects and programmes. Thus, in the first place, the intended audience for this report are evaluation officers, so that when applying the evaluation procedures and check lists, data can be organized following a systematic and logical scheme and conclusions can be derived ''objectively''. The value of such a framework for reporting on performance and in providing a quality reference for disbursements represents one of its major advantages. However, when developing and applying the IEF, it was realized that a Logical Framework Approach (LFA), like the one upon which the IEF is based, needs to be followed throughout the project life cycle, from the Country Programme Framework planning stage, through project design and implementation. Then, the helpful consequences flow into project design quality and smooth implementation. It is only in such an environment that meaningful and consistent evaluation can take place. Therefore the main audience for this report are Agency staff involved in planning, designing and implementing TC projects as well as their counterparts in Member States. In this understanding, the IEF was subjected to review by a consultants meeting, which included both external consultants and Agency staff. This Consultants Review Meeting encouraged the Secretariat to further adopt the LFA into the TC management process

  10. THE CONCEPT OF REFORMING THE HEALTHCARE INDUSTRY USING A PROJECT-BASED APPROACH

    Directory of Open Access Journals (Sweden)

    Владлен Володимирович ЛЕПСЬКИЙ

    2016-03-01

    Full Text Available The strategic goal of the state policy in the field of health Ukraine is to improve human health through providing the population with affordable and quality health care, and the development of a healthy lifestyle and expansion of preventive measures. The main problem with the current health system is called the low level of public health services. So, it is necessary to use modern innovation management technology to reform the healthcare industry. The author is invited to consider the applicability of strategic management to the management of the healthcare industry reforms through the application of innovative medical technologies and management, focusing on the development of innovations in the industry, as improving the existing health care system, and developing projects to reform and the creation of new approaches based on project management tools. The necessity of the organization of the healthcare industry focused on the development of innovations in the field of health and improvement of existing processes has been proved. A new look at the planning and implementation of Ukraine healthcare industry reforms through the integration strategic and project management has been proposed. It is shown how can be related vision, mission, goals and relevant reform programs. Further studies will be subject to the classification of projects that constitute the program, development structure programs and portfolios of projects, implementation of which will achieve the strategic goals of reforming the industry

  11. EarthServer - an FP7 project to enable the web delivery and analysis of 3D/4D models

    Science.gov (United States)

    Laxton, John; Sen, Marcus; Passmore, James

    2013-04-01

    EarthServer aims at open access and ad-hoc analytics on big Earth Science data, based on the OGC geoservice standards Web Coverage Service (WCS) and Web Coverage Processing Service (WCPS). The WCS model defines "coverages" as a unifying paradigm for multi-dimensional raster data, point clouds, meshes, etc., thereby addressing a wide range of Earth Science data including 3D/4D models. WCPS allows declarative SQL-style queries on coverages. The project is developing a pilot implementing these standards, and will also investigate the use of GeoSciML to describe coverages. Integration of WCPS with XQuery will in turn allow coverages to be queried in combination with their metadata and GeoSciML description. The unified service will support navigation, extraction, aggregation, and ad-hoc analysis on coverage data from SQL. Clients will range from mobile devices to high-end immersive virtual reality, and will enable 3D model visualisation using web browser technology coupled with developing web standards. EarthServer is establishing open-source client and server technology intended to be scalable to Petabyte/Exabyte volumes, based on distributed processing, supercomputing, and cloud virtualization. Implementation will be based on the existing rasdaman server technology developed. Services using rasdaman technology are being installed serving the atmospheric, oceanographic, geological, cryospheric, planetary and general earth observation communities. The geology service (http://earthserver.bgs.ac.uk/) is being provided by BGS and at present includes satellite imagery, superficial thickness data, onshore DTMs and 3D models for the Glasgow area. It is intended to extend the data sets available to include 3D voxel models. Use of the WCPS standard allows queries to be constructed against single or multiple coverages. For example on a single coverage data for a particular area can be selected or data with a particular range of pixel values. Queries on multiple surfaces can be

  12. The Lifestyle Project: Challenging Students to Redefine their Approach to Resource Use (Invited)

    Science.gov (United States)

    Kirk, K.

    2009-12-01

    three weeks they frequently come away with a positive outlook on the possibilities of practical energy and water conservation. Students also gain a personal understanding of the scale of global energy use and the degree of effort required to reduce impacts such as greenhouse gas emissions. In a follow-up survey of students who had completed the project during the previous three years, 81% reported they had changed their habits in permanent ways. Thus, the project has been shown to help students make important strides in changing their approach to resource use.

  13. Risk Assessment Integrated QbD Approach for Development of Optimized Bicontinuous Mucoadhesive Limicubes for Oral Delivery of Rosuvastatin.

    Science.gov (United States)

    Javed, Md Noushad; Kohli, Kanchan; Amin, Saima

    2018-04-01

    Statins are widely prescribed for hyperlipidemia, cancer, and Alzheimer's disease but are facing some inherent challenges such as low solubility and drug loading, higher hepatic metabolism, as well as instability at gastric pH. So, relatively higher circulating dose, required for exerting the therapeutic benefits, leads to dose-mediated severe toxicity. Furthermore, due to low biocompatibility, high toxicity, and other regulatory caveats such as product conformity, reproducibility, and stability of conventional formulations as well as preferentially higher bioabsorption of lipids in their favorable cuboidal geometry, enhancement in in vivo biopharmaceutical performance of Rosuvastatin could be well manifested in Quality by Design (QbD) integrated cuboidal-shaped mucoadhesive microcrystalline delivery systems (Limicubes). Here, quality-target-product-profile (QTPPs), critical quality attributes (CQAs), Ishikawa fishbone diagram, and integration of risk management through risk assessment matrix for failure mode and effects analysis (FMEA) followed by processing of Plackett-Burman design matrix using different statistical test for the first time established an approach to substantiate the claims that controlling levels of only these three screened out independent process variables, i.e., Monoolein (B = 800-1100 μL), Poloxamer (C = 150-200 mg), and stirring speed (F = 700-1000 rpm) were statistically significant to modulate and improve the biopharmaceutical performance affecting key attributes, viz., average particle size (Y 1  = 1.40-2.70 μ), entrapment efficiency (Y 2  = 62.60-88.80%), and drug loading (Y 3  = 0.817-1.15%), in QbD-enabled process. The optimal performance of developed Limicubes exhibited an average particle size of 1.8 ± 0.2 μ, entrapment efficiency 80.32 ± 2.88%, and drug loading 0.93 ± 0.08% at the level of 1100 μL (+ 1), 200 mg (+ 1), and 700 rpm (- 1) for Monoolein, Poloxamer, and stirring

  14. Feasibility of a unified approach to intensity-modulated radiation therapy and volume-modulated arc therapy optimization and delivery

    International Nuclear Information System (INIS)

    Hoover, Douglas A.; Chen, Jeff Z.; MacFarlane, Michael; Wong, Eugene; Battista, Jerry J.

    2015-01-01

    Purpose: To study the feasibility of unified intensity-modulated arc therapy (UIMAT) which combines intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) optimization and delivery to produce superior radiation treatment plans, both in terms of dose distribution and efficiency of beam delivery when compared with either VMAT or IMRT alone. Methods: An inverse planning algorithm for UIMAT was prototyped within the PINNACLE treatment planning system (Philips Healthcare). The IMRT and VMAT deliveries are unified within the same arc, with IMRT being delivered at specific gantry angles within the arc. Optimized gantry angles for the IMRT and VMAT phases are assigned automatically by the inverse optimization algorithm. Optimization of the IMRT and VMAT phases is done simultaneously using a direct aperture optimization algorithm. Five treatment plans each for prostate, head and neck, and lung were generated using a unified optimization technique and compared with clinical IMRT or VMAT plans. Delivery verification was performed with an ArcCheck phantom (Sun Nuclear) on a Varian TrueBeam linear accelerator (Varian Medical Systems). Results: In this prototype implementation, the UIMAT plans offered the same target dose coverage while reducing mean doses to organs at risk by 8.4% for head-and-neck cases, 5.7% for lung cases, and 3.5% for prostate cases, compared with the VMAT or IMRT plans. In addition, UIMAT can be delivered with similar efficiency as VMAT. Conclusions: In this proof-of-concept work, a novel radiation therapy optimization and delivery technique that interlaces VMAT or IMRT delivery within the same arc has been demonstrated. Initial results show that unified VMAT/IMRT has the potential to be superior to either standard IMRT or VMAT

  15. A simplified approach to the PROMETHEE method for priority setting in management of mine action projects

    Directory of Open Access Journals (Sweden)

    Marko Mladineo

    2016-12-01

    Full Text Available In the last 20 years, priority setting in mine actions, i.e. in humanitarian demining, has become an increasingly important topic. Given that mine action projects require management and decision-making based on a multi -criteria approach, multi-criteria decision-making methods like PROMETHEE and AHP have been used worldwide for priority setting. However, from the aspect of mine action, where stakeholders in the decision-making process for priority setting are project managers, local politicians, leaders of different humanitarian organizations, or similar, applying these methods can be difficult. Therefore, a specialized web-based decision support system (Web DSS for priority setting, developed as part of the FP7 project TIRAMISU, has been extended using a module for developing custom priority setting scenarios in line with an exceptionally easy, user-friendly approach. The idea behind this research is to simplify the multi-criteria analysis based on the PROMETHEE method. Therefore, a simplified PROMETHEE method based on statistical analysis for automated suggestions of parameters such as preference function thresholds, interactive selection of criteria weights, and easy input of criteria evaluations is presented in this paper. The result is web-based DSS that can be applied worldwide for priority setting in mine action. Additionally, the management of mine action projects is supported using modules for providing spatial data based on the geographic information system (GIS. In this paper, the benefits and limitations of a simplified PROMETHEE method are presented using a case study involving mine action projects, and subsequently, certain proposals are given for the further research.

  16. The Challenge of Integrating OHS into Industrial Project Risk Management: Proposal of a Methodological Approach to Guide Future Research (Case of Mining Projects in Quebec, Canada

    Directory of Open Access Journals (Sweden)

    Adel Badri

    2015-06-01

    Full Text Available Although risk management tools are put to good use in many industrial sectors, some large projects have been met with numerous problems due to failure to take occupational health and safety (OHS into consideration. In spite of the high level of risk and uncertainty associated with many industrial projects, the number of studies of methods for managing all known risks systematically remains small. Under effervescent economic conditions, industries must meet several challenges associated with frequent project start-ups. In highly complex and uncertain environments, rigorous management of risk remains indispensable for avoiding threats to the success of projects. Many businesses seek continually to create and improve integrated approaches to risk management. This article puts into perspective the complexity of the challenge of integrating OHS into industrial project risk management. A conceptual and methodological approach is proposed to guide future research focused on meeting this challenge. The approach is based on applying multi-disciplinary research modes to a complex industrial context in order to identify all scenarios likely to contain threats to humans or the environment. A case study is used to illustrate the potential of the proposed approach for application and its contribution to meeting the challenge of taking OHS into consideration. On-site researchers were able to develop a new approach that helped two mining companies in Quebec (Canada to achieve successful integration of OHS into expansion projects.

  17. From Adopt-a-Project to Permanent Services: The Evolution of Water For People’s Approach to Rural Water Supply in Bolivia

    Directory of Open Access Journals (Sweden)

    Kate Fogelberg

    2013-10-01

    Full Text Available The dominant paradigm in rural water provision in Bolivia has focused on the provision of infrastructure, whether by government agencies or international cooperation groups. However, the investment in infrastructure has led neither to universal access for all Bolivians nor to consistently high levels of services for those who do have access to a water system. This paper will describe the transition of one international non-profit organisation, Water For People, from supporting dispersed water projects throughout the country towards targeted support of water services at the municipal level, aiming to support permanent universal services. The institutional evolution – including changes in governance, implementation strategy, donor base, and indicators of success – that allowed field programmes to shift from projects to services provides the context for the change of approach in Bolivia. A discussion of the various aspects that have changed in the organisation’s operations in seven municipalities in Bolivia, from the scale of intervention, to municipal-wide planning information and tools, to support to service providers and service authorities, and an increased focus on post-construction monitoring, demonstrates how the Everyone, Forever approach is resulting in a more service- delivery-oriented approach in Bolivia.

  18. Delivery of Functionality in Complex Food Systems: Physically Inspired Approaches from Nanoscale to Microscale, Wageningen 18-21 October 2009

    NARCIS (Netherlands)

    Linden, van der E.; Ubbink, J.; Duchateau, G.

    2010-01-01

    The Wageningen Delivery of Functionality symposium covered all aspects involved with food structural design to arrive at high-quality foods which meet demanding customer expectations and regulatory requirements. The symposium integrated aspects from the structural organization of foods at molecular

  19. Complex approach in telecommunication engineering education: develop engineering skills by a team project

    Directory of Open Access Journals (Sweden)

    Scripcariu Luminița

    2017-01-01

    Full Text Available This paper provides an overview of the educational process of telecommunication engineering students by presenting the preparation of a team project focused on information security. Our educational approach combines basic knowledge such as mathematics with specialized engineering notions and various skills. The project theme is to design, implement and test an encryption algorithm. Students are provided with online courses, specific software programs and Internet access. They have to choose an encryption algorithm, to study its details and to write the script of the encryption algorithm in MATLAB program. The algorithm is implemented in C/C++ programming language and tested. Finally, a concurrent team tries to break the algorithm by finding the decryption key. It is an interactive approach which combines various education methods including gaming concepts. The covered topics provide students professional outcomes such as knowledge and use of specific mathematical tools and software environments (C/C ++ programming languages, MATLAB, abilities to design, develop, implement and test software algorithms. The project also provides transversal outcomes such as ability to team work, skills of computer use and information technology and capability to take responsibilities. Creativity is also encouraged by extending the algorithm to other encryption key lengths than the usual ones.

  20. Cytoplasmic transduction peptide (CTP): New approach for the delivery of biomolecules into cytoplasm in vitro and in vivo

    International Nuclear Information System (INIS)

    Kim, Daeyou; Jeon, Choonju; Kim, Jeong-Hwan; Kim, Mi-Seon; Yoon, Cheol-Hee; Choi, In-Soo; Kim, Sung-Hoon; Bae, Yong-Soo

    2006-01-01

    The protein transduction domain (PTD) of HIV-1 TAT has been extensively documented with regard to its membrane transduction potential, as well as its efficient delivery of biomolecules in vivo. However, the majority of PTD and PTD-conjugated molecules translocate to the nucleus rather than to the cytoplasm after transduction, due to the functional nuclear localization sequence (NLS). Here, we report a cytoplasmic transduction peptide (CTP), which was deliberately designed to ensure the efficient cytoplasmic delivery of the CTP-fused biomolecules. In comparison with PTD, CTP and its fusion partners exhibited a clear preference for cytoplasmic localization, and also markedly enhanced membrane transduction potential. Unlike the mechanism underlying PTD-mediated transduction, CTP-mediated transduction occurs independently of the lipid raft-dependent macropinocytosis pathway. The CTP-conjugated Smac/DIABLO peptide (Smac-CTP) was also shown to be much more efficient than Smac-PTD in the blockage of the antiapoptotic properties of XIAP, suggesting that cytoplasmic functional molecules can be more efficiently targeted by CTP-mediated delivery. In in vivo trafficking studies, CTP-fused β-gal exhibited unique organ tropisms to the liver and lymph nodes when systemically injected into mice, whereas PTD-β-gal exhibited no such tropisms. Taken together, our findings implicate CTP as a novel delivery peptide appropriate for (i) molecular targeting to cytoplasmic compartments in vitro, (ii) the development of class I-associated CTL vaccines, and (iii) special drug delivery in vivo, without causing any untoward effects on nuclear genetic material

  1. Proven approaches to organise a large decommissioning project, including the management of local stakeholder interests

    International Nuclear Information System (INIS)

    Rodriguez, A.

    2005-01-01

    Full text: Spanish experience holds a relatively important position in the field of the decommissioning of nuclear and radioactive facilities. Decommissioning projects of uranium concentrate mill facilities are near completion; some old uranium mine sites have already been restored; several projects for the dismantling of various small research nuclear reactors and a few pilot plants are at various phases of the dismantling process, with some already completed. The most notable Spanish project in this field is undoubtedly the decommissioning of the Vandellos 1 nuclear power plant that is currently ready to enter a safe enclosure, or dormancy, period. The management of radioactive wastes in Spain is undertaken by 'Empresa Nacional de Residuos Radioactivos, S.A.' (ENRESA), the Spanish national radioactive waste company, constituted in 1984. ENRESA operates as a management company, whose role is to develop radioactive waste management programmes in accordance with the policy and strategy approved by the Spanish Government. Its responsibilities include the decommissioning and dismantling of nuclear installations. Decommissioning and dismantling nuclear installations is an increasingly important topic for governments, regulators, industries and civil society. There are many aspects that have to be carefully considered, planned and organised in many cases well in advance of when they really need to be implemented. The goal of this paper is describe proven approaches relevant to organizing and managing large decommissioning projects, in particular in the case of Vandellos-1 NPP decommissioning. (author)

  2. Project Management Consultancy (PMC) procurement approach: Supplier's evaluation and selection dilemma

    Science.gov (United States)

    Nawi, Mohd Nasrun Mohd; Azimi, Mohd Azrulfitri; Pozin, Mohd Affendi Ahmad; Osman, Wan Nadri; Anuar, Herman Shah

    2016-08-01

    Project Management Consultancy (PMC) is part of the management oriented procurement method in which a sole consultant is hired by the client to deal with the contactors in place of the client. Appointing contractors in this method or approach looks to be interesting as client could play a pivotal role in evaluating and selecting the supplier/contractor for the work package. In some cases, client gives the authority for the PMC to hire the supplier/contractor of their choice while in some cases the client is the one who made the decision. This research paper seeks to investigate the dilemma arises from this situation and for the purpose of this research, a real case study was studied to assess the impacts of such dilemma to the performance of the project. Recommendations on how to tackle the dilemma will also be addressed in the later part of this research paper.

  3. Chromosomocentric approach to overcoming difficulties in implementation of international project Human Proteome

    Directory of Open Access Journals (Sweden)

    A. I. Archakov

    2013-12-01

    Full Text Available The international project Human Proteome (PHP, being a logical continuation of the project Human Genome, was started on September 23, 2010. In correspondence with the genocentric approach, the PHP aim is to prepare a catalogue of all human proteins and to decipher a network of their interactions. The PHP implementation difficulties arise because the research subject itself – proteome – is much more complicated than genome. The major problem is the insufficient sensitivity of proteome methods that does not allow detecting low- and ultralow-copy proteins. Bad reproducibility of proteome methods and the lack of so-called “gold standard” is the second major complicacy in PHP implementation. The third problem is the dynamic character of proteome, its instabili­ty in time. The paper deals with possible variants of overcoming these complicacies, preventing from successful implementation of PHP.

  4. A learning curve approach to projecting cost and performance for photovoltaic technologies

    Science.gov (United States)

    Cody, George D.; Tiedje, Thomas

    1997-04-01

    The current cost of electricity generated by PV power is still extremely high with respect to power supplied by the utility grid, and there remain questions as to whether PV power can ever be competitive with electricity generated by fossil fuels. An objective approach to this important question was given in a previous paper by the authors which introduced analytical tools to define and project the technical/economic status of PV power from 1988 through the year 2010. In this paper, we apply these same tools to update the conclusions of our earlier study in the context of recent announcements by Amoco/Enron-Solarex of projected sales of PV power at rates significantly less than the US utility average.

  5. Learning curve approach to projecting cost and performance for photovoltaic technologies

    Science.gov (United States)

    Cody, George D.; Tiedje, Thomas

    1997-10-01

    The current cost of electricity generated by PV power is still extremely high with respect to power supplied by the utility grid, and there remain questions as to whether PV power can ever be competitive with electricity generated by fossil fuels. An objective approach to this important question was given in a previous paper by the authors which introduced analytical tools to define and project the technical/economic status of PV power from 1988 through the year 2010. In this paper, we apply these same tools to update the conclusions of our earlier study in the context of recent announcements by Amoco/Enron-Solar of projected sales of PV power at rates significantly less than the U.S. utility average.

  6. Core Standards of the EUBIROD Project. Defining a European Diabetes Data Dictionary for Clinical Audit and Healthcare Delivery.

    Science.gov (United States)

    Cunningham, S G; Carinci, F; Brillante, M; Leese, G P; McAlpine, R R; Azzopardi, J; Beck, P; Bratina, N; Bocquet, V; Doggen, K; Jarosz-Chobot, P K; Jecht, M; Lindblad, U; Moulton, T; Metelko, Ž; Nagy, A; Olympios, G; Pruna, S; Skeie, S; Storms, F; Di Iorio, C T; Massi Benedetti, M

    2016-01-01

    A set of core diabetes indicators were identified in a clinical review of current evidence for the EUBIROD project. In order to allow accurate comparisons of diabetes indicators, a standardised currency for data storage and aggregation was required. We aimed to define a robust European data dictionary with appropriate clinical definitions that can be used to analyse diabetes outcomes and provide the foundation for data collection from existing electronic health records for diabetes. Existing clinical datasets used by 15 partner institutions across Europe were collated and common data items analysed for consistency in terms of recording, data definition and units of measurement. Where necessary, data mappings and algorithms were specified in order to allow partners to meet the standard definitions. A series of descriptive elements were created to document metadata for each data item, including recording, consistency, completeness and quality. While datasets varied in terms of consistency, it was possible to create a common standard that could be used by all. The minimum dataset defined 53 data items that were classified according to their feasibility and validity. Mappings and standardised definitions were used to create an electronic directory for diabetes care, providing the foundation for the EUBIROD data analysis repository, also used to implement the diabetes registry and model of care for Cyprus. The development of data dictionaries and standards can be used to improve the quality and comparability of health information. A data dictionary has been developed to be compatible with other existing data sources for diabetes, within and beyond Europe.

  7. A phased approach to cooperative environmental management R ampersand D projects with Russian institutes

    International Nuclear Information System (INIS)

    Matalucci, R.V.; Albert, T.E.

    1994-01-01

    An important aspect of technology exchange between the US and the Former Society Union (FSU) countries is the identification and implementation of cooperative projects that are mutually beneficial. The US Department of Energy (DOE) and its national laboratories have established a four-phase approach to identify and further develop Russian technologies that could contribute to solving DOE environmental management problems. Following an initial screening and identification of potential technologies, the country-to-country interaction is formally initiated in the first phase through a small-scale pilot project study. This phase consists of an evaluation of the specific technology for DOE applications, and provides an opportunity for both US and Russian scientists and engineers to validate the use of the technology for a specific DOE requirement. The successful completion of this phase establishes the basis for continuing the technology development into the second phase, which includes laboratory testing in Russia. In the third phase, the technology is laboratory tested in the US, most likely at those DOE national laboratories having the capability and greatest interest in the particular technology area. The fourth and final phase consist of a commercialization process that establishes a partnership with a US business to finalize development of the technology and to prepare for implementation within the DOE complex. An example of this phased approach is a current high-level waste separation cooperative project between the Khlopin Radium Institute and the DOE through Sandia National Laboratories (SNL) and Science Applications International Corporation (SAIC). This effort has not only enhanced separations technology for the DOE, but has also provided an example of a working process for future cooperative projects

  8. Construction safety monitoring based on the project's characteristic with fuzzy logic approach

    Science.gov (United States)

    Winanda, Lila Ayu Ratna; Adi, Trijoko Wahyu; Anwar, Nadjadji; Wahyuni, Febriana Santi

    2017-11-01

    Construction workers accident is the highest number compared with other industries and falls are the main cause of fatal and serious injuries in high rise projects. Generally, construction workers accidents are caused by unsafe act and unsafe condition that can occur separately or together, thus a safety monitoring system based on influencing factors is needed to achieve zero accident in construction industry. The dynamic characteristic in construction causes high mobility for workers while doing the task, so it requires a continuously monitoring system to detect unsafe condition and to protect workers from potential hazards. In accordance with the unique nature of project, fuzzy logic approach is one of the appropriate methods for workers safety monitoring on site. In this study, the focus of discussion is based on the characteristic of construction projects in analyzing "potential hazard" and the "protection planning" to be used in accident prevention. The data have been collected from literature review, expert opinion and institution of safety and health. This data used to determine hazard identification. Then, an application model is created using Delphi programming. The process in fuzzy is divided into fuzzification, inference and defuzzification, according to the data collection. Then, the input and final output data are given back to the expert for assessment as a validation of application model. The result of the study showed that the potential hazard of construction workers accident could be analysed based on characteristic of project and protection system on site and fuzzy logic approach can be used for construction workers accident analysis. Based on case study and the feedback assessment from expert, it showed that the application model can be used as one of the safety monitoring tools.

  9. The Saale-Project -A multidisciplinary approach towards sustainable integrative catchment management -

    Science.gov (United States)

    Bongartz, K.; Flügel, W. A.

    2003-04-01

    In the joint research project “Development of an integrated methodology for the sustainable management of river basins The Saale River Basin example”, coordinated by the Centre of Environmental Research (UFZ), concepts and tools for an integrated management of large river basins are developed and applied for the Saale river basin. The ultimate objective of the project is to contribute to the holistic assessment and benchmarking approaches in water resource planning, as required by the European Water Framework Directive. The study presented here deals (1) with the development of a river basin information and modelling system, (2) with the refinement of a regionalisation approach adapted for integrated basin modelling. The approach combines a user friendly basin disaggregation method preserving the catchment’s physiographic heterogeneity with a process oriented hydrological basin assessment for scale bridging integrated modelling. The well tested regional distribution concept of Response Units (RUs) will be enhanced by landscape metrics and decision support tools for objective, scale independent and problem oriented RU delineation to provide the spatial modelling entities for process oriented and distributed simulation of vertical and lateral hydrological transport processes. On basis of this RUs suitable hydrological modelling approaches will be further developed with strong respect to a more detailed simulation of the lateral surface and subsurface flows as well as the channel flow. This methodical enhancement of the well recognised RU-concept will be applied to the river basin of the Saale (Ac: 23 179 km2) and validated by a nested catchment approach, which allows multi-response-validation and estimation of uncertainties of the modelling results. Integrated modelling of such a complex basin strongly influenced by manifold human activities (reservoirs, agriculture, urban areas and industry) can only be achieved by coupling the various modelling approaches

  10. Acceptability of delivery of dietary advice in the dentistry setting to address obesity in pre-school children: a case study of the Common Risk Factor Approach.

    Science.gov (United States)

    Henderson, Emily J

    2015-07-01

    The Common Risk Factor Approach proposes that public health efforts can be improved by multiple agencies working together on a shared risk factor. The present study aimed to assess the acceptability to parents, dental practice staff and commissioners of the delivery of dietary advice in the dentistry setting in order to address obesity. Semi-structured focus groups with dental practice staff and one-to-one interviews with parents of pre-school children and public health commissioners involved in an oral health promotion initiative delivering dietary advice in dental surgeries. Data were analysed using the Framework Approach. General dental practice surgeries and pre-schools in areas of high deprivation in north-east England. Parents (n 4), dental practice staff (n 23) and one commissioner. All participants found acceptable the concept of delivering public health messages in non-conventional settings. Dental practice staff were concerned about the potential for conflicting messages and deprioritisation of oral health advice, and they identified practical barriers to delivery, such as lack of training. Parents were very apprehensive about the potential of such approaches to stigmatise overweight children, including bullying. Uncertainty over the causes of obesity led to confusion about its solutions and the roles of public health and health care. Major concerns about the implementation of the Common Risk Factor Approach were raised by parents and dental practice staff. Specific dietary guidance for both oral health and healthy weight, as well as further research into issues of suitability, feasibility and stigmatisation, are needed.

  11. Android arcade game app a real world project : case study approach

    CERN Document Server

    DiMarzio, Jerome

    2012-01-01

    Apress, the leading Android books publisher, continues to provide you with very hands-on, practical books for teaching and showing app developers how to build and design apps, including game apps, that can be built and deployed in the various Android app stores out there. Android Arcade Game App:  A Real World Project - Case Study Approach is no different in that it walks you through creating an arcade style Prison Break game app-top to bottom-for an Android smartphone or tablet.  This book teaches you the unique characteristics and challenges of creating an Arcade style game And it provides y

  12. A bottom-up approach to estimating cost elements of REDD+ pilot projects in Tanzania

    Directory of Open Access Journals (Sweden)

    Merger Eduard

    2012-08-01

    Full Text Available Abstract Background Several previous global REDD+ cost studies have been conducted, demonstrating that payments for maintaining forest carbon stocks have significant potential to be a cost-effective mechanism for climate change mitigation. These studies have mostly followed highly aggregated top-down approaches without estimating the full range of REDD+ costs elements, thus underestimating the actual costs of REDD+. Based on three REDD+ pilot projects in Tanzania, representing an area of 327,825 ha, this study explicitly adopts a bottom-up approach to data assessment. By estimating opportunity, implementation, transaction and institutional costs of REDD+ we develop a practical and replicable methodological framework to consistently assess REDD+ cost elements. Results Based on historical land use change patterns, current region-specific economic conditions and carbon stocks, project-specific opportunity costs ranged between US$ -7.8 and 28.8 tCOxxxx for deforestation and forest degradation drivers such as agriculture, fuel wood production, unsustainable timber extraction and pasture expansion. The mean opportunity costs for the three projects ranged between US$ 10.1 – 12.5 tCO2. Implementation costs comprised between 89% and 95% of total project costs (excluding opportunity costs ranging between US$ 4.5 - 12.2 tCO2 for a period of 30 years. Transaction costs for measurement, reporting, verification (MRV, and other carbon market related compliance costs comprised a minor share, between US$ 0.21 - 1.46 tCO2. Similarly, the institutional costs comprised around 1% of total REDD+ costs in a range of US$ 0.06 – 0.11 tCO2. Conclusions The use of bottom-up approaches to estimate REDD+ economics by considering regional variations in economic conditions and carbon stocks has been shown to be an appropriate approach to provide policy and decision-makers robust economic information on REDD+. The assessment of opportunity costs is a crucial first step to

  13. A bottom-up approach to estimating cost elements of REDD+ pilot projects in Tanzania

    Science.gov (United States)

    2012-01-01

    Background Several previous global REDD+ cost studies have been conducted, demonstrating that payments for maintaining forest carbon stocks have significant potential to be a cost-effective mechanism for climate change mitigation. These studies have mostly followed highly aggregated top-down approaches without estimating the full range of REDD+ costs elements, thus underestimating the actual costs of REDD+. Based on three REDD+ pilot projects in Tanzania, representing an area of 327,825 ha, this study explicitly adopts a bottom-up approach to data assessment. By estimating opportunity, implementation, transaction and institutional costs of REDD+ we develop a practical and replicable methodological framework to consistently assess REDD+ cost elements. Results Based on historical land use change patterns, current region-specific economic conditions and carbon stocks, project-specific opportunity costs ranged between US$ -7.8 and 28.8 tCOxxxx for deforestation and forest degradation drivers such as agriculture, fuel wood production, unsustainable timber extraction and pasture expansion. The mean opportunity costs for the three projects ranged between US$ 10.1 – 12.5 tCO2. Implementation costs comprised between 89% and 95% of total project costs (excluding opportunity costs) ranging between US$ 4.5 - 12.2 tCO2 for a period of 30 years. Transaction costs for measurement, reporting, verification (MRV), and other carbon market related compliance costs comprised a minor share, between US$ 0.21 - 1.46 tCO2. Similarly, the institutional costs comprised around 1% of total REDD+ costs in a range of US$ 0.06 – 0.11 tCO2. Conclusions The use of bottom-up approaches to estimate REDD+ economics by considering regional variations in economic conditions and carbon stocks has been shown to be an appropriate approach to provide policy and decision-makers robust economic information on REDD+. The assessment of opportunity costs is a crucial first step to provide information on the

  14. Teaching Cell Biology to Dental Students with a Project-Based Learning Approach.

    Science.gov (United States)

    Costa-Silva, Daniela; Côrtes, Juliana A; Bachinski, Rober F; Spiegel, Carolina N; Alves, Gutemberg G

    2018-03-01

    Although the discipline of cell biology (CB) is part of the curricula of predoctoral dental schools, students often fail to recognize its practical relevance. The aim of this study was to assess the effectiveness of a practical-theoretical project-based course in closing the gaps among CB, scientific research, and dentistry for dental students. A project-based learning course was developed with nine sequential lessons to evaluate 108 undergraduate dental students enrolled in CB classes of a Brazilian school of dentistry during 2013-16. To highlight the relevance of in vitro studies in the preclinical evaluation of dental materials at the cellular level, the students were challenged to complete the process of drafting a protocol and performing a cytocompatibility assay for a bone substitute used in dentistry. Class activities included small group discussions, scientific database search and article presentations, protocol development, lab experimentation, and writing of a final scientific report. A control group of 31 students attended only one laboratory class on the same theme, and the final reports were compared between the two groups. The results showed that the project-based learning students had superior outcomes in acknowledging the relevance of in vitro methods during biocompatibility testing. Moreover, they produced scientifically sound reports with more content on methodological issues, the relationship with dentistry, and the scientific literature than the control group (p<0.05). The project-based learning students also recognized a higher relevance of scientific research and CB to dental practice. These results suggest that a project-based approach can help contextualize scientific research in dental curricula.

  15. An approach to communications security for a communications data delivery system for V2V/V2I safety : technical description and identification of policy and institutional issues.

    Science.gov (United States)

    This report identifies the security approach associated with a communications data delivery system that supports vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) communications. The report describes the risks associated with communication...

  16. Approaches in estimation of external cost for fuel cycles in the ExternE project

    International Nuclear Information System (INIS)

    Afanas'ev, A.A.; Maksimenko, B.N.

    1998-01-01

    The purposes, content and main results of studies realized within the frameworks of the International Project ExternE which is the first comprehensive attempt to develop general approach to estimation of external cost for different fuel cycles based on utilization of nuclear and fossil fuels, as well as on renewable power sources are discussed. The external cost of a fuel cycle is treated as social and environmental expenditures which are not taken into account by energy producers and consumers, i.e. these are expenditures not included into commercial cost nowadays. The conclusion on applicability of the approach suggested for estimation of population health hazards and environmental impacts connected with electric power generation growth (expressed in money or some other form) is made

  17. Investment opportunity in China's overseas oil project: An empirical analysis based on real option approach

    International Nuclear Information System (INIS)

    Tang, Bao-Jun; Zhou, Hui-Ling; Chen, Hao; Wang, Kai; Cao, Hong

    2017-01-01

    China's overseas oil investments uphold national energy security. Located in the complex international economic and political environment, the benefits of overseas oil projects are affected by various uncertainties. Oil companies call for a set of evaluation method dealing with these uncertainties, especially when encountering low-oil-price conditions. It is much more crucial to answer when to optimally invest rather than whether to invest. This paper analyzes the investment opportunity of an oil project in the development and production phase considering uncertainty, irreversibility and management flexibility. The decision-making process combines Discounted Cash Flow (DCF) method and the trinomial tree model of Real Option Approach (ROA). For practical purposes, tools of hurdle price, cumulative probability and decision tree are adopted. In addition, results of the case project show the economic feasibility at present and optimal start-up timing at the end of 2016. Besides, the lower cost parameters generally make it easier to meet the opportunity. The scenario analysis suggests the higher risk contributes to an earlier start-up. Furthermore, the issues of method applicability, investment signals and decision-lag effects are discussed. - Highlights: • Volatility is combined with fluctuations in oil price, exchange rate and political situation. • Hurdle price is adopted as a critical price to measure investment opportunity. • Scenario analysis suggests the higher risk contribute to earlier investment timing.

  18. Unique Regulatory Approach for Licensing the Port Hope Remediation Project in Canada - 13315

    International Nuclear Information System (INIS)

    Kostova, M.; Howard, D.; Elder, P.

    2013-01-01

    The Port Hope remediation project is a part of a larger initiative of the Canadian Federal Government the Port Hope Area Initiative (PHAI) which is based upon a community proposal. The Government of Canada, through Natural Resources Canada (NRCan) is investing $1.28 billion over 10 years to clean up historic low-level radioactive waste in the Port Hope Area and to provide long-term safe management of the low-level radioactive wastes in the Port Hope Area. These wastes arose from the activities of a former Federal Crown Corporation (Eldorado Nuclear) and its private sector predecessors. In Canada, historic waste are defined as low-level radioactive waste that was managed in a manner no longer considered acceptable, but for which the original producer cannot reasonably be held responsible or no longer exists and for which the Federal Government has accepted responsibility. In Canada, under the current regulatory framework, the environmental remediation is not considered as a distinct phase of the nuclear cycle. The regulatory approach for dealing with existing sites contaminated with radioactive residues is defined on the basis of risk and application of existing regulations. A unique regulatory approach was taken by the Canadian Nuclear Safety Commission (CNSC) to address the various licensing issues and to set out the requirements for licensing of the Port Hope Project within the current regulatory framework. (authors)

  19. Unique Regulatory Approach for Licensing the Port Hope Remediation Project in Canada - 13315

    Energy Technology Data Exchange (ETDEWEB)

    Kostova, M.; Howard, D.; Elder, P. [Directorate of Nuclear Cycle and Facilities Regulation, Canadian Nuclear Safety Commission, 280, Slater Street, Ottawa, Ontario K1P 5S9 (Canada)

    2013-07-01

    The Port Hope remediation project is a part of a larger initiative of the Canadian Federal Government the Port Hope Area Initiative (PHAI) which is based upon a community proposal. The Government of Canada, through Natural Resources Canada (NRCan) is investing $1.28 billion over 10 years to clean up historic low-level radioactive waste in the Port Hope Area and to provide long-term safe management of the low-level radioactive wastes in the Port Hope Area. These wastes arose from the activities of a former Federal Crown Corporation (Eldorado Nuclear) and its private sector predecessors. In Canada, historic waste are defined as low-level radioactive waste that was managed in a manner no longer considered acceptable, but for which the original producer cannot reasonably be held responsible or no longer exists and for which the Federal Government has accepted responsibility. In Canada, under the current regulatory framework, the environmental remediation is not considered as a distinct phase of the nuclear cycle. The regulatory approach for dealing with existing sites contaminated with radioactive residues is defined on the basis of risk and application of existing regulations. A unique regulatory approach was taken by the Canadian Nuclear Safety Commission (CNSC) to address the various licensing issues and to set out the requirements for licensing of the Port Hope Project within the current regulatory framework. (authors)

  20. Comparative analysis of methodical approaches to evaluating the efficiency of investment projects in the power industry

    International Nuclear Information System (INIS)

    Tolstooukhov, D.A.; Karkhov, A.N.

    2001-01-01

    At present time, a transition is made to market mechanisms of economy functioning based on equilibrium price formation for products of enterprises and their self-financing. Based on long-term forecasts of economic development, electric power industry should not only ensure preservation of the accumulated potential but should also provide for modernization, reconstruction, service life extension of operating power facilities and construction of new ones. Under market conditions, nuclear power installations will have to prove their right to exist and develop in competition with other power technologies. In these conditions, the responsibility is growing for the correctness of investment decisions taken in the power industry and methods on which they are based. This paper analyzes currently used calculation methods for economic efficiency of investment projects. It emphasizes the limitations and drawbacks of the existing methodical approaches, and their inconsistency with market economy and scientific and technological progress (STP). The said drawbacks lead to serious mistakes in evaluating the prospects for the development of nuclear power. The paper describes a methodical approach based on equilibrium price formation that does not have the said drawbacks and may be used as the basis for further work on creation of improved calculation methods for the economic efficiency of investment projects in nuclear power. (authors)

  1. A CONSTRUCTIVIST APPROACH TO THE DESIGN AND DELIVERY OF AN ONLINE PROFESSIONAL DEVELOPMENT COURSE: A CASE OF THE iEARN ONLINE COURSE

    Directory of Open Access Journals (Sweden)

    Lockias Chitanana

    2012-01-01

    Full Text Available This study examined the International Education and Resource Network Science Technology and Math (iEARN-STM online professional development course. The study used the constructivist framework as the conceptual model to examine the way in which the constructivist theory has shaped the design and implementation of the course, as reflected by the interactions of a cohort of participants in the course. The participants were 28 educators enrolled in the course, who were either teacher educators or teachers, working in different educational institutions in different countries throughout the world. The purpose of the study was to understand how the iEARN online professional development course supported teachers’ learning through effective discourse in an online environment and to identify the constructivist learning principles that were behind the success of the course. The design of the course appeared to have a positive impact on participants’ collaboration with peers. Results of the study confirms earlier research findings that the constructivist approach to course design and delivery provides a powerful structure for creating learning environments conducive to the development of professional skills among educators. Results of this study can be used to assist professional development coordinators and administrators to plan effective professional development. The results of the study are also expected to contribute to improvements in the design of professional development course content, instruction, delivery and administration, focusing on factors such as program model, delivery, contextual factors or best practices.

  2. Development Approach of the Advanced Life Support On-line Project Information System

    Science.gov (United States)

    Levri, Julie A.; Hogan, John A.; Morrow, Rich; Ho, Michael C.; Kaehms, Bob; Cavazzoni, Jim; Brodbeck, Christina A.; Whitaker, Dawn R.

    2005-01-01

    The Advanced Life Support (ALS) Program has recently accelerated an effort to develop an On-line Project Information System (OPIS) for research project and technology development data centralization and sharing. There has been significant advancement in the On-line Project Information System (OPIS) over the past year (Hogan et al, 2004). This paper presents the resultant OPIS development approach. OPIS is being built as an application framework consisting of an uderlying Linux/Apache/MySQL/PHP (LAMP) stack, and supporting class libraries that provides database abstraction and automatic code generation, simplifying the ongoing development and maintenance process. Such a development approach allows for quick adaptation to serve multiple Programs, although initial deployment is for an ALS module. OPIS core functionality will involve a Web-based annual solicitation of project and technology data directly from ALS Principal Investigators (PIs) through customized data collection forms. Data provided by PIs will be reviewed by a Technical Task Monitor (TTM) before posting the information to OPIS for ALS Community viewing via the Web. Such Annual Reports will be permanent, citable references within OPIS. OPlS core functionality will also include Project Home Sites, which will allow PIS to provide updated technology information to the Community in between Annual Report updates. All data will be stored in an object-oriented relational database, created in MySQL(Reistered Trademark) and located on a secure server at NASA Ames Research Center (ARC). Upon launch, OPlS can be utilized by Managers to identify research and technology development (R&TD) gaps and to assess task performance. Analysts can employ OPlS to obtain the current, comprehensive, accurate information about advanced technologies that is required to perform trade studies of various life support system options. ALS researchers and technology developers can use OPlS to achieve an improved understanding of the NASA

  3. Intercomparison of hydrological model structures and calibration approaches in climate scenario impact projections

    Science.gov (United States)

    Vansteenkiste, Thomas; Tavakoli, Mohsen; Ntegeka, Victor; De Smedt, Florimond; Batelaan, Okke; Pereira, Fernando; Willems, Patrick

    2014-11-01

    calibration was tested by comparing the manual calibration approach with automatic calibrations of the VHM model based on different objective functions. The calibration approach did not significantly alter the model results for peak flow, but the low flow projections were again highly influenced. Model choice as well as calibration strategy hence have a critical impact on low flows, more than on peak flows. These results highlight the high uncertainty in low flow modelling, especially in a climate change context.

  4. The Australian national reactive phosphate rock project - Aims, experimental approach, and site characteristics

    International Nuclear Information System (INIS)

    McLaughlin, M.J.

    2002-01-01

    Field-based cutting trials were established across Australia in a range of environments to evaluate the agronomic effectiveness of 5 phosphate rocks, and 1 partially acidulated phosphate rock, relative to either single super-phosphate or triple superphosphate. The phosphate rocks differed in reactivity, as determined by the degree of carbonate substitution for phosphate in the apatite structure and solubility of phosphorus present in the fertilizers in 2% formic acid, 2% citric acid and neutral ammonium citrate. Sechura (Bayovar) and North Carolina phosphate rocks were highly reactive (>70% solubility in 2% formic acid), whilst Khouribja (Moroccan) and Hamrawein (Egypt) phosphate rock were moderately reactive. Duchess phosphate rock from Queensland was relatively unreactive ( 2 , from 4.0 to 5.1, and Colwell extractable phosphorus ranged from 3 to 47 μg/g prior to fertilizer application. Two core experiments were established at each site. The first measured the effects of phosphate rock reactivity on agronomic effectiveness, while the second core experiment measured the effects of the degree of water solubility of the phosphorus source on agronomic effectiveness. The National Reactive Phosphate Rock Project trials provided the opportunity to confirm the suitability of accepted procedures to model fertilizer response and to develop new approaches for comparing different fertilizer responses. The Project also provided the framework for subsidiary studies such as the effect of fertilizer source on soil phosphorus extractability; cadmium and fluorine concentrations in herbage; evaluation of soil phosphorus tests; and the influence of particle size on phosphate rock effectiveness. The National Reactive Phosphate Rock Project presents a valuable model for a large, Australia-wide, collaborative team approach to an important agricultural issue. The use of standard and consistent experimental methodologies at every site ensured that maximum benefit was obtained from data

  5. Waste Feed Delivery Environmental Permits and Approvals Plan

    Energy Technology Data Exchange (ETDEWEB)

    TOLLEFSON, K.S.

    2000-01-18

    This plan describes the environmental permits approvals, and other requirements that may affect establishment of a waste feed delivery system for the Hanford Site's River Protection Project. This plan identifies and screens environmental standards for potential applicability, outlines alternatives for satisfying applicable standards, and describes preferred permitting and approval approaches.

  6. Waste Feed Delivery Environmental Permits and Approvals Plan

    International Nuclear Information System (INIS)

    TOLLEFSON, K.S.

    2000-01-01

    This plan describes the environmental permits approvals, and other requirements that may affect establishment of a waste feed delivery system for the Hanford Site's River Protection Project. This plan identifies and screens environmental standards for potential applicability, outlines alternatives for satisfying applicable standards, and describes preferred permitting and approval approaches

  7. Technical Approach and Plan for Transitioning Spent Nuclear Fuel (SNF) Project Facilities to the Environmental Restoration Program

    International Nuclear Information System (INIS)

    SKELLY, W.A.

    1999-01-01

    This document describes the approach and process in which the 100-K Area Facilities are to be deactivated and transitioned over to the Environmental Restoration Program after spent nuclear fuel has been removed from the K Basins. It describes the Transition Project's scope and objectives, work breakdown structure, activity planning, estimated cost, and schedule. This report will be utilized as a planning document for project management and control and to communicate details of project content and integration

  8. The CASE Project: Evaluation of Case-Based Approaches to Learning and Teaching in Statistics Service Courses

    Science.gov (United States)

    Fawcett, Lee

    2017-01-01

    The CASE project (Case-based Approaches to Statistics Education; see www.mas.ncl.ac.uk/~nlf8/innovation) was established to investigate how the use of real-life, discipline-specific case study material in Statistics service courses could improve student engagement, motivation, and confidence. Ultimately, the project aims to promote deep learning…

  9. Teaching Introductory Oceanography through Case Studies: Project based approach for general education students

    Science.gov (United States)

    Farnsworth, K. L.; House, M.; Hovan, S. A.

    2013-12-01

    A recent workshop sponsored by SERC-On the Cutting Edge brought together science educators from a range of schools across the country to discuss new approaches in teaching oceanography. In discussing student interest in our classes, we were struck by the fact that students are drawn to emotional or controversial topics such as whale hunting and tsunami hazard and that these kinds of topics are a great vehicle for introducing more complex concepts such as wave propagation, ocean upwelling and marine chemistry. Thus, we have developed an approach to introductory oceanography that presents students with real-world issues in the ocean sciences and requires them to explore the science behind them in order to improve overall ocean science literacy among non-majors and majors at 2 and 4 year colleges. We have designed a project-based curriculum built around topics that include, but are not limited to: tsunami hazard, whale migration, ocean fertilization, ocean territorial claims, rapid climate change, the pacific trash patch, overfishing, and ocean acidification. Each case study or project consists of three weeks of class time and is structured around three elements: 1) a media analysis; 2) the role of ocean science in addressing the issue; 3) human impact/response. Content resources range from textbook readings, popular or current print news, documentary film and television, and data available on the world wide web from a range of sources. We employ a variety of formative assessments for each case study in order to monitor student access and understanding of content and include a significant component of in-class student discussion and brainstorming guided by faculty input to develop the case study. Each study culminates in summative assessments ranging from exams to student posters to presentations, depending on the class size and environment. We envision this approach for a range of classroom environments including large group face-to-face instruction as well as hybrid

  10. Experience with in vivo diode dosimetry for verifying radiotherapy dose delivery: Practical implementation of cost-effective approaches

    International Nuclear Information System (INIS)

    Thwaites, D.I.; Blyth, C.; Carruthers, L.; Elliott, P.A.; Kidane, G.; Millwater, C.J.; MacLeod, A.S.; Paolucci, M.; Stacey, C.

    2002-01-01

    A systematic programme of in vivo dosimetry using diodes to verify radiotherapy delivered doses began in Edinburgh in 1992. The aims were to investigate the feasibility of routine systematic use of diodes as part of a comprehensive QA programme, to carry out clinical pilot studies to assess the accuracy of dose delivery on each machine and for each site and technique, to identify and rectify systematic deviations, to assess departmental dosimetric precision and to compare to clinical requirements. A further aim was to carry out a cost-benefit evaluation based on the results from the pilot studies to consider how best to use diodes routinely

  11. Projectables

    DEFF Research Database (Denmark)

    Rasmussen, Troels A.; Merritt, Timothy R.

    2017-01-01

    CNC cutting machines have become essential tools for designers and architects enabling rapid prototyping, model-building and production of high quality components. Designers often cut from new materials, discarding the irregularly shaped remains. We introduce ProjecTables, a visual augmented...... reality system for interactive packing of model parts onto sheet materials. ProjecTables enables designers to (re)use scrap materials for CNC cutting that would have been previously thrown away, at the same time supporting aesthetic choices related to wood grain, avoiding surface blemishes, and other...... relevant material properties. We conducted evaluations of ProjecTables with design students from Aarhus School of Architecture, demonstrating that participants could quickly and easily place and orient model parts reducing material waste. Contextual interviews and ideation sessions led to a deeper...

  12. A Project Management Approach to M&A Deals and their Post-Integration Projects : A Case Study

    OpenAIRE

    Habibbeigi, Pooria

    2010-01-01

    Mergers and acquisitions (M&A) projects have long been considered as a strategy for organizational growth and gain of market share. Top management teams of companies take M&As into consideration since it is faster and less costly compare to internal growth and development programs. M&A project has variety of benefits such as growth in market share, increase in shareholder wealth, access to new markets, technological advantages and so on and so forth. Another benefit of such projec...

  13. Project Termination from a Benefit Realisation Management Approach : An abductive study of IT and R&D projects

    OpenAIRE

    Franco Gonzalez, Jose Miguel; Luzuriaga Ubilla, Daniela Lorena

    2018-01-01

    Bad or failing projects drain organisational resources in vain, affect team morale,and are a detriment to corporate strategy. Theimportance of terminating a project that will not deliver as promised canhardly be overemphasized, however it is still a major managerial challenge. Throughout this papera call is made toidentify andterminate failing projectsvia a benefit realisation management process, as successful projectsare only those thatdeliver the expected benefits. Thus, the research questi...

  14. The Special Place Project: Efficacy of a Place-Based Case Study Approach for Teaching Geoscience

    Science.gov (United States)

    Moosavi, Sadredin

    2014-05-01

    Achieving geoscience literacy of the general population has become increasingly important world wide as ever more connected and growing societies depend more and more on our planet's limited natural resource base. Building citizen understanding of their dependence on the local environment, and the geologic processes which created and continue to change it, has become a great challenge to educators at all levels of the education system. The Special Place Project described in this presentation explores use of a place-based case study approach combining instruction in geoscience content with development of observation, reasoning, writing and presentation skills. The approach allows students to select the locations for their individual case studies affording development of personal connections between the learner and his environment. The approach gives instructors at many grade levels the ability to develop core pedagogical content and skills while exploring the unique geologic environments relevant to the local population including such critical issues as land use, resource depletion, energy, climate change and the future of communities in a changing world. The geologic reasons for the location of communities and key events in their histories can be incorporated into the students' case studies as appropriate. The project is unique in placing all course instruction in the context of the quest to explore and gain understanding of the student's chosen location by using the inherently more generalized course content required by the curriculum. By modeling how scientists approach their research questions, this pedagogical technique not only integrates knowledge and skills from across the curriculum, it captures the excitement of scientific thinking on real world questions directly relevant to students' lives, increasing student engagement and depth of learning as demonstrated in the case study reports crafted by the students and exam results. Student learning of topics

  15. A knowledge translation project on community-centred approaches in public health.

    Science.gov (United States)

    Stansfield, J; South, J

    2018-03-01

    This article examines the development and impact of a national knowledge translation project aimed at improving access to evidence and learning on community-centred approaches for health and wellbeing. Structural changes in the English health system meant that knowledge on community engagement was becoming lost and a fragmented evidence base was seen to impact negatively on policy and practice. A partnership started between Public Health England, NHS England and Leeds Beckett University in 2014 to address these issues. Following a literature review and stakeholder consultation, evidence was published in a national guide to community-centred approaches. This was followed by a programme of work to translate the evidence into national strategy and local practice.The article outlines the key features of the knowledge translation framework developed. Results include positive impacts on local practice and national policy, for example adoption within National Institute for Health and Care Evidence (NICE) guidance and Local Authority public health plans and utilization as a tool for local audit of practice and commissioning. The framework was successful in its non-linear approach to knowledge translation across a range of inter-connected activity, built on national leadership, knowledge brokerage, coalition building and a strong collaboration between research institute and government agency.

  16. A nonlinear dynamics approach for incorporating wind-speed patterns into wind-power project evaluation.

    Science.gov (United States)

    Huffaker, Ray; Bittelli, Marco

    2015-01-01

    Wind-energy production may be expanded beyond regions with high-average wind speeds (such as the Midwest U.S.A.) to sites with lower-average speeds (such as the Southeast U.S.A.) by locating favorable regional matches between natural wind-speed and energy-demand patterns. A critical component of wind-power evaluation is to incorporate wind-speed dynamics reflecting documented diurnal and seasonal behavioral patterns. Conventional probabilistic approaches remove patterns from wind-speed data. These patterns must be restored synthetically before they can be matched with energy-demand patterns. How to accurately restore wind-speed patterns is a vexing problem spurring an expanding line of papers. We propose a paradigm shift in wind power evaluation that employs signal-detection and nonlinear-dynamics techniques to empirically diagnose whether synthetic pattern restoration can be avoided altogether. If the complex behavior of observed wind-speed records is due to nonlinear, low-dimensional, and deterministic system dynamics, then nonlinear dynamics techniques can reconstruct wind-speed dynamics from observed wind-speed data without recourse to conventional probabilistic approaches. In the first study of its kind, we test a nonlinear dynamics approach in an application to Sugarland Wind-the first utility-scale wind project proposed in Florida, USA. We find empirical evidence of a low-dimensional and nonlinear wind-speed attractor characterized by strong temporal patterns that match up well with regular daily and seasonal electricity demand patterns.

  17. Nanomedicine for therapeutic drug therapy: Approaches to increase the efficacy of drug therapy with nanoemulsion delivery and reduce the toxicity of quantum dots

    Science.gov (United States)

    Kambalapally, Swetha Reddy

    fluorescent labels. They have been studied extensively due to their interesting optical and electrical properties. The study of their applications has led to their use as novel platforms for delivery into living systems for use in medical imaging. The second part of this thesis discusses the toxicity of the various semiconductor nanocrystals, CdSe and InP. The results show the toxicity of CdSe and InP QDs in in vitro cultures of whole skin biopsies exposed to similar concentrations. This forms the basis for further studies involving QDs and approaches to reduce the toxicity of these nanoparticles. Finally, ligand exchange mediated Solutol HS-15 modified CdSe QDs were prepared for the first time. The modified CdSe QDs demonstrated long term stability and reduced cytotoxicity. Such behavior is interpreted as arising from decreased aggregation of the QDs due to the incorporation of the surfactant.

  18. A translational approach for limb vascular delivery of the micro-dystrophin gene without high volume or high pressure for treatment of Duchenne muscular dystrophy

    Directory of Open Access Journals (Sweden)

    Chicoine Louis G

    2007-09-01

    Full Text Available Abstract Background Duchenne muscular dystrophy (DMD is an X-linked recessive disorder with monogenic mutations setting the stage for successful gene therapy treatment. We have completed a study that directly deals with the following key issues that can be directly adapted to a gene therapy clinical trial using rAAV considering the following criteria: 1 A regional vascular delivery approach that will protect the patient from widespread dissemination of virus; 2 an approach to potentially facilitate safe passage of the virus for efficient skeletal muscle transduction; 3 the use of viral doses to accommodate current limitations imposed by vector production methods; 4 and at the same time, achieve a clinically meaningful outcome by transducing multiple muscles in the lower limb to prolong ambulation. Methods The capacity of AAV1, AAV6 or AAV8 to cross the vascular endothelial barrier carrying a micro-dystrophin cDNA was compared under identical conditions with delivery through a catheter placed in the femoral artery of the mdx mouse. Transduction efficiency was assessed by immuno-staining using an antibody (Manex1a that recognizes the N-terminus of micro-dystrophin. The degree of physiologic correction was assessed by measuring tetanic force and protection from eccentric contraction in the extensor digitorum longus muscle (EDL. The vascular delivery paradigm found successful in the mouse was carried to the non-human primate to test its potential translation to boys with DMD. Results Regional vascular delivery resulted in transduction by rAAV8.micro-dystrophin reaching 94.5 ± 0.9 (1 month, 91.3 ± 3.1 (2 months, and 89.6 ± 1.6% (3 months. rAAV6.micro-dystrophin treated animals demonstrated 87.7 ± 6.8 (1 month, 78.9 ± 7.4 (2 months, and 81.2 ± 6.2% (3 months transduction. In striking contrast, rAAV1 demonstrated very low transduction efficiency [0.9 ± 0.3 (1 month, 2.1 ± 0.8 (2 months, and 2.1 ± 0.7% (3 months] by vascular delivery. Micro

  19. Projecting changes in the distribution and productivity of living marine resources: A critical review of the suite of modelling approaches used in the large European project VECTORS

    NARCIS (Netherlands)

    Peck, Myron A.; Arvanitidis, Christos; Butenschön, Momme; Canu, Donata Melaku; Chatzinikolaou, Eva; Cucco, Andrea; Domenici, Paolo; Fernandes, Jose A.; Gasche, Loic; Huebert, Klaus B.; Hufnagl, Marc; Jones, Miranda C.; Kempf, Alexander; Keyl, Friedemann; Maar, Marie; Mahévas, Stéphanie; Marchal, Paul; Nicolas, Delphine; Pinnegar, John K.; Rivot, Etienne; Rochette, Sébastien; Sell, Anne F.; Sinerchia, Matteo; Solidoro, Cosimo; Somerfield, Paul J.; Teal, Lorna R.; Travers-trolet, Morgan; De Wolfshaar, Van Karen E.

    2018-01-01

    We review and compare four broad categories of spatially-explicit modelling approaches currently used to understand and project changes in the distribution and productivity of living marine resources including: 1) statistical species distribution models, 2) physiology-based, biophysical models of

  20. Comparison of Different Approach of Back Projection Method in Retrieving the Rupture Process of Large Earthquakes

    Science.gov (United States)

    Tan, F.; Wang, G.; Chen, C.; Ge, Z.

    2016-12-01

    Back-projection of teleseismic P waves [Ishii et al., 2005] has been widely used to image the rupture of earthquakes. Besides the conventional narrowband beamforming in time domain, approaches in frequency domain such as MUSIC back projection (Meng 2011) and compressive sensing (Yao et al, 2011), are proposed to improve the resolution. Each method has its advantages and disadvantages and should be properly used in different cases. Therefore, a thorough research to compare and test these methods is needed. We write a GUI program, which puts the three methods together so that people can conveniently use different methods to process the same data and compare the results. Then we use all the methods to process several earthquake data, including 2008 Wenchuan Mw7.9 earthquake and 2011 Tohoku-Oki Mw9.0 earthquake, and theoretical seismograms of both simple sources and complex ruptures. Our results show differences in efficiency, accuracy and stability among the methods. Quantitative and qualitative analysis are applied to measure their dependence on data and parameters, such as station number, station distribution, grid size, calculate window length and so on. In general, back projection makes it possible to get a good result in a very short time using less than 20 lines of high-quality data with proper station distribution, but the swimming artifact can be significant. Some ways, for instance, combining global seismic data, could help ameliorate this method. Music back projection needs relatively more data to obtain a better and more stable result, which means it needs a lot more time since its runtime accumulates obviously faster than back projection with the increase of station number. Compressive sensing deals more effectively with multiple sources in a same time window, however, costs the longest time due to repeatedly solving matrix. Resolution of all the methods is complicated and depends on many factors. An important one is the grid size, which in turn influences

  1. Toward a model of socializing project team members : An integrative approach

    NARCIS (Netherlands)

    Batistič, S.; Kenda, R.

    2018-01-01

    Project work is becoming more and more important in everyday business, as is staffing the right newcomers for the project. Recognizing that not all new project team workers possess equally important specific knowledge, skills and abilities for the success of projects, we draw on project management,

  2. Waste feed delivery test and evaluation plan

    Energy Technology Data Exchange (ETDEWEB)

    O' TOOLE, S.M.

    1999-09-30

    This plan documents the Waste Feed Delivery Program test and evaluation planning and implementation approach. The purpose of this document is to define and communicate the Waste Feed Delivery Program Test and Evaluation scope, objectives, planning and implementation approach.

  3. Waste feed delivery test and evaluation plan

    International Nuclear Information System (INIS)

    O'TOOLE, S.M.

    1999-01-01

    This plan documents the Waste Feed Delivery Program test and evaluation planning and implementation approach. The purpose of this document is to define and communicate the Waste Feed Delivery Program Test and Evaluation scope, objectives, planning and implementation approach

  4. Project management approach for the Waste Area Grouping 6 Closure/Remediation Project at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    1992-07-01

    This document has been developed as a preliminary definition of the Waste Area Grouping (WAG) 6 Closure Project Management Approach. The purpose of this document is to identify the roles and responsibilities of the various project team members and to identify the project scope, schedule and budget. This document is intended to be a living document. As information develops, this document will be revised to create a WAG 6 Project Management Plan (PMP). The PMP will provide additional focus to the information contained in this document. The information required will be available as the selected alternative for remediation of WAG 6 is approved and Remedial Action Plans are conceptualized. This document has been reviewed against, and is intended to be consistent with, the Environmental Restoration Program Management Plan

  5. Multicontroller: an object programming approach to introduce advanced control algorithms for the GCS large scale project

    CERN Document Server

    Cabaret, S; Coppier, H; Rachid, A; Barillère, R; CERN. Geneva. IT Department

    2007-01-01

    The GCS (Gas Control System) project team at CERN uses a Model Driven Approach with a Framework - UNICOS (UNified Industrial COntrol System) - based on PLC (Programming Language Controller) and SCADA (Supervisory Control And Data Acquisition) technologies. The first' UNICOS versions were able to provide a PID (Proportional Integrative Derivative) controller whereas the Gas Systems required more advanced control strategies. The MultiController is a new UNICOS object which provides the following advanced control algorithms: Smith Predictor, PFC (Predictive Function Control), RST* and GPC (Global Predictive Control). Its design is based on a monolithic entity with a global structure definition which is able to capture the desired set of parameters of any specific control algorithm supported by the object. The SCADA system -- PVSS - supervises the MultiController operation. The PVSS interface provides users with supervision faceplate, in particular it links any MultiController with recipes: the GCS experts are ab...

  6. Story, History and Intercultural Memory: Can a Transmedia Approach Benefit an Archive-Based Documentary Project?

    Directory of Open Access Journals (Sweden)

    Marida Di Crosta

    2016-12-01

    Full Text Available How can transmedia storytelling benefit to a documentary production in order to give historical archives a second life? Could it possibly help updating official archives, adding to the them amateur’s contributions? We will try to answer the question by recalling some recent European experiences of Web-documentaries linked to television series. This will allows us to extrapolate a few theoretical fundamentals underlying the design of our transcontinental transmedia collaborative project of archive-based documentary – Histories of Brazil. Our aim is to show how a transmedia approach to archive-based content, intervening in contemporary digital interconnected environements, can work as a dynamic complementary tool for developing and sharing historical knowledge.

  7. A scaling approach to project regional sea level rise and its uncertainties

    Directory of Open Access Journals (Sweden)

    M. Perrette

    2013-01-01

    Full Text Available Climate change causes global mean sea level to rise due to thermal expansion of seawater and loss of land ice from mountain glaciers, ice caps and ice sheets. Locally, sea level can strongly deviate from the global mean rise due to changes in wind and ocean currents. In addition, gravitational adjustments redistribute seawater away from shrinking ice masses. However, the land ice contribution to sea level rise (SLR remains very challenging to model, and comprehensive regional sea level projections, which include appropriate gravitational adjustments, are still a nascent field (Katsman et al., 2011; Slangen et al., 2011. Here, we present an alternative approach to derive regional sea level changes for a range of emission and land ice melt scenarios, combining probabilistic forecasts of a simple climate model (MAGICC6 with the new CMIP5 general circulation models. The contribution from ice sheets varies considerably depending on the assumptions for the ice sheet projections, and thus represents sizeable uncertainties for future sea level rise. However, several consistent and robust patterns emerge from our analysis: at low latitudes, especially in the Indian Ocean and Western Pacific, sea level will likely rise more than the global mean (mostly by 10–20%. Around the northeastern Atlantic and the northeastern Pacific coasts, sea level will rise less than the global average or, in some rare cases, even fall. In the northwestern Atlantic, along the American coast, a strong dynamic sea level rise is counteracted by gravitational depression due to Greenland ice melt; whether sea level will be above- or below-average will depend on the relative contribution of these two factors. Our regional sea level projections and the diagnosed uncertainties provide an improved basis for coastal impact analysis and infrastructure planning for adaptation to climate change.

  8. An Objective Approach to Select Climate Scenarios when Projecting Species Distribution under Climate Change.

    Directory of Open Access Journals (Sweden)

    Nicolas Casajus

    Full Text Available An impressive number of new climate change scenarios have recently become available to assess the ecological impacts of climate change. Among these impacts, shifts in species range analyzed with species distribution models are the most widely studied. Whereas it is widely recognized that the uncertainty in future climatic conditions must be taken into account in impact studies, many assessments of species range shifts still rely on just a few climate change scenarios, often selected arbitrarily. We describe a method to select objectively a subset of climate change scenarios among a large ensemble of available ones. Our k-means clustering approach reduces the number of climate change scenarios needed to project species distributions, while retaining the coverage of uncertainty in future climate conditions. We first show, for three biologically-relevant climatic variables, that a reduced number of six climate change scenarios generates average climatic conditions very close to those obtained from a set of 27 scenarios available before reduction. A case study on potential gains and losses of habitat by three northeastern American tree species shows that potential future species distributions projected from the selected six climate change scenarios are very similar to those obtained from the full set of 27, although with some spatial discrepancies at the edges of species distributions. In contrast, projections based on just a few climate models vary strongly according to the initial choice of climate models. We give clear guidance on how to reduce the number of climate change scenarios while retaining the central tendencies and coverage of uncertainty in future climatic conditions. This should be particularly useful during future climate change impact studies as more than twice as many climate models were reported in the fifth assessment report of IPCC compared to the previous one.

  9. An Objective Approach to Select Climate Scenarios when Projecting Species Distribution under Climate Change.

    Science.gov (United States)

    Casajus, Nicolas; Périé, Catherine; Logan, Travis; Lambert, Marie-Claude; de Blois, Sylvie; Berteaux, Dominique

    2016-01-01

    An impressive number of new climate change scenarios have recently become available to assess the ecological impacts of climate change. Among these impacts, shifts in species range analyzed with species distribution models are the most widely studied. Whereas it is widely recognized that the uncertainty in future climatic conditions must be taken into account in impact studies, many assessments of species range shifts still rely on just a few climate change scenarios, often selected arbitrarily. We describe a method to select objectively a subset of climate change scenarios among a large ensemble of available ones. Our k-means clustering approach reduces the number of climate change scenarios needed to project species distributions, while retaining the coverage of uncertainty in future climate conditions. We first show, for three biologically-relevant climatic variables, that a reduced number of six climate change scenarios generates average climatic conditions very close to those obtained from a set of 27 scenarios available before reduction. A case study on potential gains and losses of habitat by three northeastern American tree species shows that potential future species distributions projected from the selected six climate change scenarios are very similar to those obtained from the full set of 27, although with some spatial discrepancies at the edges of species distributions. In contrast, projections based on just a few climate models vary strongly according to the initial choice of climate models. We give clear guidance on how to reduce the number of climate change scenarios while retaining the central tendencies and coverage of uncertainty in future climatic conditions. This should be particularly useful during future climate change impact studies as more than twice as many climate models were reported in the fifth assessment report of IPCC compared to the previous one.

  10. Operational challenges in conducting a community-based technology-enabled mental health services delivery model for rural India: Experiences from the SMART Mental Health Project [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Pallab K. Maulik

    2018-04-01

    Full Text Available Background: There are large gaps in the delivery of mental health care in low- and middle-income countries such as India, and the problems are even more acute in rural settings due to lack of resources, remoteness, and lack of infrastructure, amongst other factors. The Systematic Medical Appraisal Referral and Treatment (SMART Mental Health Project was conceived as a mental health services delivery model using technology-based solutions for rural India. This paper reports on the operational strategies used to facilitate the implementation of the intervention. Method: Key components of the SMART Mental Health Project included delivering an anti-stigma campaign, training of primary health workers in screening, diagnosing and managing stress, depression and increased suicide risk and task sharing of responsibilities in delivering care; and using mobile technology based electronic decision support systems to support delivery of algorithm based care for such disorders. The intervention was conducted in 42 villages across two sites in the state of Andhra Pradesh in south India. A pre-post mixed methods evaluation was done, and in this paper operational challenges are reported. Results: Both quantitative and qualitative results from the evaluation from one site covering about 5000 adults showed that the intervention was feasible and acceptable, and initial results indicated that it was beneficial in increasing access to mental health care and reducing depression and anxiety symptoms. A number of strategies were initiated in response to operational challenges to ensure smoother conduct of the project and facilitated the project to be delivered as envisaged. Conclusions: The operational strategies initiated for this project were successful in ensuring the delivery of the intervention. Those, coupled with other more systematic processes have informed the researchers to understand key processes that need to be in place to develop a more robust study, that

  11. Project management for small business: a streamlined approach from planning to completion

    National Research Council Canada - National Science Library

    Phillips, Joseph

    2012-01-01

    ... a Project Management Plan 81 72 Developing the Work Breakdown Structure 85 76 Selecting Your Project Management Software 83 65 CHAPTER 4: MANAGING PROJECT COSTS Building a Cost Management Frame...

  12. Technical approach to finalizing sensible soil cleanup levels at the Fernald Environmental Management Project

    International Nuclear Information System (INIS)

    Carr, D.; Hertel, B.; Jewett, M.; Janke, R.; Conner, B.

    1996-01-01

    The remedial strategy for addressing contaminated environmental media was recently finalized for the US Department of Energy's (DOE) Fernald Environmental Management Project (FEMP) following almost 10 years of detailed technical analysis. The FEMP represents one of the first major nuclear facilities to successfully complete the Remedial Investigation/Feasibility Study (RI/FS) phase of the environmental restoration process. A critical element of this success was the establishment of sensible cleanup levels for contaminated soil and groundwater both on and off the FEMP property. These cleanup levels were derived based upon a strict application of Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) regulations and guidance, coupled with positive input from the regulatory agencies and the local community regarding projected future land uses for the site. The approach for establishing the cleanup levels was based upon a Feasibility Study (FS) strategy that examined a bounding range of viable future land uses for the site. Within each land use, the cost and technical implications of a range of health-protective cleanup levels for the environmental media were analyzed. Technical considerations in driving these cleanup levels included: direct exposure routes to viable human receptors; cross- media impacts to air, surface water, and groundwater; technical practicality of attaining the levels; volume of affected media; impact to sensitive environmental receptors or ecosystems; and cost. This paper will discuss the technical approach used to support the finalization of the cleanup levels for the site. The final cleanup levels provide the last remaining significant piece to the puzzle of establishing a final site-wide remedial strategy for the FEMP, and positions the facility for the expedient completion of site-wide remedial activities

  13. An Object-Based Approach to Evaluation of Climate Variability Projections and Predictions

    Science.gov (United States)

    Ammann, C. M.; Brown, B.; Kalb, C. P.; Bullock, R.

    2017-12-01

    Evaluations of the performance of earth system model predictions and projections are of critical importance to enhance usefulness of these products. Such evaluations need to address specific concerns depending on the system and decisions of interest; hence, evaluation tools must be tailored to inform about specific issues. Traditional approaches that summarize grid-based comparisons of analyses and models, or between current and future climate, often do not reveal important information about the models' performance (e.g., spatial or temporal displacements; the reason behind a poor score) and are unable to accommodate these specific information needs. For example, summary statistics such as the correlation coefficient or the mean-squared error provide minimal information to developers, users, and decision makers regarding what is "right" and "wrong" with a model. New spatial and temporal-spatial object-based tools from the field of weather forecast verification (where comparisons typically focus on much finer temporal and spatial scales) have been adapted to more completely answer some of the important earth system model evaluation questions. In particular, the Method for Object-based Diagnostic Evaluation (MODE) tool and its temporal (three-dimensional) extension (MODE-TD) have been adapted for these evaluations. More specifically, these tools can be used to address spatial and temporal displacements in projections of El Nino-related precipitation and/or temperature anomalies, ITCZ-associated precipitation areas, atmospheric rivers, seasonal sea-ice extent, and other features of interest. Examples of several applications of these tools in a climate context will be presented, using output of the CESM large ensemble. In general, these tools provide diagnostic information about model performance - accounting for spatial, temporal, and intensity differences - that cannot be achieved using traditional (scalar) model comparison approaches. Thus, they can provide more

  14. A Hybrid MCDM Approach for Strategic Project Portfolio Selection of Agro By-Products

    Directory of Open Access Journals (Sweden)

    Animesh Debnath

    2017-07-01

    Full Text Available Due to the increasing size of the population, society faces several challenges for sustainable and adequate agricultural production, quality, distribution, and food safety in the strategic project portfolio selection (SPPS. The initial adaptation of strategic portfolio management of genetically modified (GM Agro by-products (Ab-Ps is a huge challenge in terms of processing the agro food product supply-chain practices in an environmentally nonthreatening way. As a solution to the challenges, the socio-economic characteristics for SPPS of GM food purchasing scenarios are studied. Evaluation and selection of the GM agro portfolio management are the dynamic issues due to physical and immaterial criteria involving a hybrid multiple criteria decision making (MCDM approach, combining modified grey Decision-Making Trial and Evaluation Laboratory (DEMATEL, Multi-Attributive Border Approximation area Comparison (MABAC and sensitivity analysis. Evaluation criteria are grouped into social, differential and beneficial clusters, and the modified DEMATEL procedure is used to derive the criteria weights. The MABAC method is applied to rank the strategic project portfolios according to the aggregated preferences of decision makers (DMs. The usefulness of the proposed research framework is validated with a case study. The GM by-products are found to be the best portfolio. Moreover, this framework can unify the policies of agro technological improvement, corporate social responsibility (CSR and agro export promotion.

  15. 3D virtual character reconstruction from projections: a NURBS-based approach

    Science.gov (United States)

    Triki, Olfa; Zaharia, Titus B.; Preteux, Francoise J.

    2004-05-01

    This work has been carried out within the framework of the industrial project, so-called TOON, supported by the French government. TOON aims at developing tools for automating the traditional 2D cartoon content production. This paper presents preliminary results of the TOON platform. The proposed methodology concerns the issues of 2D/3D reconstruction from a limited number of drawn projections, and 2D/3D manipulation/deformation/refinement of virtual characters. Specifically, we show that the NURBS-based modeling approach developed here offers a well-suited framework for generating deformable 3D virtual characters from incomplete 2D information. Furthermore, crucial functionalities such as animation and non-rigid deformation can be also efficiently handled and solved. Note that user interaction is enabled exclusively in 2D by achieving a multiview constraint specification method. This is fully consistent and compliant with the cartoon creator traditional practice and makes it possible to avoid the use of 3D modeling software packages which are generally complex to manipulate.

  16. FDM 3D printing of modified drug-delivery systems using hot melt extrusion: a new approach for individualized therapy.

    Science.gov (United States)

    Cunha-Filho, Marcilio; Araújo, Maísa Rp; Gelfuso, Guilherme M; Gratieri, Tais

    2017-11-01

    The production process of 3D-printed drugs offers unique advantages such as the possibility of individualizing the drug therapy and easily associating different drugs and release technologies in the same pharmaceutical unit. Fused deposition modeling, a 3D printing technique, seems especially interesting for pharmaceutical applications, due to its low cost, precise and reproducible control of the printed structures, and versatility for industrial and laboratory scale. This technique combined with another technology already adapted for the pharmaceutical industry, the hot melt extrusion, is able to incorporate various mechanisms of modified drug release. This special report aims to bring together data of the experimental progress achieved using the fused deposition modeling 3D printing combined with hot melt extrusion technique and its potential in drug delivery. [Formula: see text].

  17. A statistical experimental design approach to evaluate the influence of various penetration enhancers on transdermal drug delivery of buprenorphine

    Directory of Open Access Journals (Sweden)

    S.Mojtaba Taghizadeh

    2015-03-01

    Full Text Available A series of drug-in-adhesive transdermal drug delivery systems (patch with different chemical penetration enhancers were designed to deliver drug through the skin as a site of application. The objective of our effort was to study the influence of various chemical penetration enhancers on skin permeation rate and adhesion properties of a transdermal drug delivery system using Box–Behnken experimental design. The response surface methodology based on a three-level, three-variable Box–Behnken design was used to evaluate the interactive effects on dependent variables including, the rate of skin permeation and adhesion properties, namely peel strength and tack value. Levulinic acid, lauryl alcohol, and Tween 80 were used as penetration enhancers (patch formulations, containing 0–8% of each chemical penetration enhancer. Buprenorphine was used as a model penetrant drug. The results showed that incorporation of 20% chemical penetration enhancer into the mixture led to maximum skin permeation flux of buprenorphine from abdominal rat skin while the adhesion properties decreased. Also that skin flux in presence of levulinic acid (1.594 μg/cm2 h was higher than Tween 80 (1.473 μg/cm2 h and lauryl alcohol (0.843 μg/cm2 h, and in mixing these enhancers together, an additional effect was observed. Moreover, it was found that each enhancer increased the tack value, while levulinic acid and lauryl alcohol improved the peel strength but Tween 80 reduced it. These findings indicated that the best chemical skin penetration enhancer for buprenorphine patch was levulinic acid. Among the designed formulations, the one which contained 12% (wt/wt enhancers exhibited the highest efficiency.

  18. Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: what should be the policy?

    Science.gov (United States)

    Kateb, Babak; Chiu, Katherine; Black, Keith L; Yamamoto, Vicky; Khalsa, Bhavraj; Ljubimova, Julia Y; Ding, Hui; Patil, Rameshwar; Portilla-Arias, Jose Antonio; Modo, Mike; Moore, David F; Farahani, Keyvan; Okun, Michael S; Prakash, Neal; Neman, Josh; Ahdoot, Daniel; Grundfest, Warren; Nikzad, Shouleh; Heiss, John D

    2011-01-01

    Nanotechnology is the design and assembly of submicroscopic devices called nanoparticles, which are 1-100 nm in diameter. Nanomedicine is the application of nanotechnology for the diagnosis and treatment of human disease. Disease-specific receptors on the surface of cells provide useful targets for nanoparticles. Because nanoparticles can be engineered from components that (1) recognize disease at the cellular level, (2) are visible on imaging studies, and (3) deliver therapeutic compounds, nanotechnology is well suited for the diagnosis and treatment of a variety of diseases. Nanotechnology will enable earlier detection and treatment of diseases that are best treated in their initial stages, such as cancer. Advances in nanotechnology will also spur the discovery of new methods for delivery of therapeutic compounds, including genes and proteins, to diseased tissue. A myriad of nanostructured drugs with effective site-targeting can be developed by combining a diverse selection of targeting, diagnostic, and therapeutic components. Incorporating immune target specificity with nanostructures introduces a new type of treatment modality, nano-immunochemotherapy, for patients with cancer. In this review, we will discuss the development and potential applications of nanoscale platforms in medical diagnosis and treatment. To impact the care of patients with neurological diseases, advances in nanotechnology will require accelerated translation to the fields of brain mapping, CNS imaging, and nanoneurosurgery. Advances in nanoplatform, nano-imaging, and nano-drug delivery will drive the future development of nanomedicine, personalized medicine, and targeted therapy. We believe that the formation of a science, technology, medicine law-healthcare policy (STML) hub/center, which encourages collaboration among universities, medical centers, US government, industry, patient advocacy groups, charitable foundations, and philanthropists, could significantly facilitate such

  19. A statistical experimental design approach to evaluate the influence of various penetration enhancers on transdermal drug delivery of buprenorphine.

    Science.gov (United States)

    Taghizadeh, S Mojtaba; Moghimi-Ardakani, Ali; Mohamadnia, Fatemeh

    2015-03-01

    A series of drug-in-adhesive transdermal drug delivery systems (patch) with different chemical penetration enhancers were designed to deliver drug through the skin as a site of application. The objective of our effort was to study the influence of various chemical penetration enhancers on skin permeation rate and adhesion properties of a transdermal drug delivery system using Box-Behnken experimental design. The response surface methodology based on a three-level, three-variable Box-Behnken design was used to evaluate the interactive effects on dependent variables including, the rate of skin permeation and adhesion properties, namely peel strength and tack value. Levulinic acid, lauryl alcohol, and Tween 80 were used as penetration enhancers (patch formulations, containing 0-8% of each chemical penetration enhancer). Buprenorphine was used as a model penetrant drug. The results showed that incorporation of 20% chemical penetration enhancer into the mixture led to maximum skin permeation flux of buprenorphine from abdominal rat skin while the adhesion properties decreased. Also that skin flux in presence of levulinic acid (1.594 μg/cm(2) h) was higher than Tween 80 (1.473 μg/cm(2) h) and lauryl alcohol (0.843 μg/cm(2) h), and in mixing these enhancers together, an additional effect was observed. Moreover, it was found that each enhancer increased the tack value, while levulinic acid and lauryl alcohol improved the peel strength but Tween 80 reduced it. These findings indicated that the best chemical skin penetration enhancer for buprenorphine patch was levulinic acid. Among the designed formulations, the one which contained 12% (wt/wt) enhancers exhibited the highest efficiency.

  20. Proposed approach for developing process-based KPIs for project control during the pre-project stage

    NARCIS (Netherlands)

    Haponava, T.; Al-Jibouri, Saad H.S.; Mawdesley, M.; Ahmed, Syed M.; Azhar, Salman; Mohamed, Sherif

    2007-01-01

    In recent years a great deal of attention has been made to measuring different aspects of construction project performance. Some of the tools used for this purpose are the Key Performance Indicators (KPIs). The main shortcoming of these however is that most of them are end product oriented and hence