WorldWideScience

Sample records for project aurora ii

  1. Aurora Mine project - historical resources baseline study

    International Nuclear Information System (INIS)

    Reeves, B.

    1996-01-01

    This volume contains the results of a base line archaeological study of the Aurora Mine Project local study area. It was compiled in support of Syncrude Canada's application to the Alberta Energy and Utilities Board (AEUB) and Alberta Environmental Protection to construct and operate it new Aurora Mine, located northeast of Fort McMurray, Alberta. The objective of this study was to compile, consolidate, review and analyze the reports for the area compiled over the past 22 years in and adjacent to the local study area (LSA), particularly those of now existing and Syncrude projects, and previously proposed Alsands and OSLO projects. The report is a summary of the human history in the area including pre-contact native archaeological sites, past archaeological studies, the Hinterland site pattern, post-contact native traditional sites, oil sands exploration/development related sites and paleontological sites in the subject area, and areas adjacent to it. 150 refs., 5 tabs., 43 figs

  2. Project Aether Aurora: STEM outreach near the arctic circle

    Science.gov (United States)

    Longmier, B. W.; Bering, E. A.

    2012-12-01

    Project Aether is a program designed to immerse high-school through graduate students to field research in some of the fields of STEM. The program leaders launch high altitude weather balloons in collaboration with schools and students to teach physics concepts, experimental research skills, and to make space exploration accessible to students. A weather balloon lifts a specially designed payload package that is composed of HD cameras, GPS tracking devices, and other science equipment. The payload is constructed and attached to the balloon by the students with low-cost materials. The balloon and payload are launched with FAA clearance from a site chosen based on wind patterns and predicted landing locations. The balloon ascends over 2 hours to a maximum altitude of 100,000 feet where it bursts and allows the payload to slowly descend using a built-in parachute. The balloon's location is monitored during its flight by GPS-satellite relay. Most of the science and video data are recorded on SD cards using an Arduino digitizer. The payload is located using the GPS device. The science data are recovered from the payload and shared with the students. In April 2012, Project Aether leaders conducted a field campaign near Fairbanks Alaska, sending several student-built experiments to an altitude of 30km, underneath several strong auroral displays. Auroral physics experiments that can be done on ultra small balloons (5 cubic meters) include electric field and magnetic fluctuation observations, full spectrum and narrow band optical imaging, GPS monitoring of the total electron content of the ionosphere, x-ray detection and infrared and UV spectroscopy. The actual undergraduate student experiments will be reviewed and some data presented.; Balloon deployment underneath aurora, Fairbanks Alaska, 2012.

  3. Proteomic analysis of human metaphase chromosomes reveals Topoisomerase II alpha as an Aurora B substrate

    DEFF Research Database (Denmark)

    Morrison, Ciaran; Henzing, Alexander J; Jensen, Ole Nørregaard

    2002-01-01

    B in the presence of radioactive ATP. Immunoblot analysis confirmed the HeLa scaffold fraction to be enriched for known chromosomal proteins including CENP-A, CENP-B, CENP-C, ScII and INCENP. Mass spectrometry of bands excised from one-dimensional polyacrylamide gels further defined the protein......The essential Aurora B kinase is a chromosomal passenger protein that is required for mitotic chromosome alignment and segregation. Aurora B function is dependent on the chromosome passenger, INCENP. INCENP, in turn, requires sister chromatid cohesion for its appropriate behaviour. Relatively few...... composition of the extracted chromosome fraction. Cloning, fluorescent tagging and expression in HeLa cells of the putative GTP-binding protein NGB/CRFG demonstrated it to be a novel mitotic chromosome protein, with a perichromosomal localisation. Identi fication of the protein bands corresponding to those...

  4. Aurora Borealis. Project Cycle Management in Regional Development

    OpenAIRE

    Andra Aldea-Partanen; Heimo Keränen; Susanna Nevalainen

    2003-01-01

    This paper aims to analyse Project Cycle Management approach in the context of regional development. The theoretical framework covers contemporary concepts typical for regional development and specific project/programme management tools. The comparative approach is used to take into account the two versions of Project Cycle Management presented by European Commission among evaluation methods and instruments, in 1993 and 2001. A practical application is drawn using mid-term evaluation of Baren...

  5. Ozone Satellite Data Synergy and Combination with Non-satellite Data in the AURORA project

    Science.gov (United States)

    Cortesi, U.; Tirelli, C.; Arola, A.; Dragani, R.; Keppens, A.; Loenen, E.; Masini, A.; Tsiakos, , C.; van der A, R.; Verberne, K.

    2017-12-01

    The geostationary satellite constellation composed of TEMPO (North America), SENTINEL-4 (Europe) and GEMS (Asia) missions is a major instance of space component in the fundamentally new paradigm aimed at integrating information on air quality from a wide variety of sources. Space-borne data on tropospheric composition from new generation satellites have a growing impact in this context because of their unprecedented quantity and quality, while merging with non-satellite measurements and other types of auxiliary data via state-of-the-art modelling capabilities remains essential to fit the purpose of highly accurate information made readily available at high temporal and spatial resolution, both in analysis and forecast mode. Proper and effective implementation of this paradigm poses severe challenges to science, technology and applications that must be addressed in a closely interconnected manner to pave the way to high quality products and innovative services. Novel ideas and tools built on these three pillars are currently under investigation in the AURORA (Advanced Ultraviolet Radiation and Ozone Retrieval for Applications) Horizon 2020 project of the European Commission. The primary goal of the project is the proof of concept of a synergistic approach to the exploitation of Sentinel-4 and -5 Ozone measurements in the UV, Visible and Thermal Infrared based on the combination of an innovative data fusion method and assimilation models. The scientific objective shares the same level of priority with the technological effort to realize a prototype data processor capable to manage the full data processing chain and with the development of two downstream applications for demonstration purposes. The presentation offers a first insight in mid-term results of the project, which is mostly based on the use of synthetic data from the atmospheric Sentinels. Specific focus is given to the role of satellite data synergy in integrated systems for air quality monitoring, in

  6. AuroraMAX!

    Science.gov (United States)

    Donovan, E.; Spanswick, E. L.; Chicoine, R.; Pugsley, J.; Langlois, P.

    2011-12-01

    AuroraMAX is a public outreach and education initiative that brings auroral images to the public in real time. AuroraMAX utilizes an observing station located just outside Yellowknife, Canada. The station houses a digital All-Sky Imager (ASI) that collects full-colour images of the night sky every six seconds. These images are then transmitted via satellite internet to our web server, where they are made instantly available to the public. Over the last two years this program has rapidly become one of the most successful outreach programs in the history of Space Science in Canada, with hundreds of thousands of distinct visitors to the CSA AuroraMAX website, thousands of followers on social media, and hundreds of newspaper, magazine, radio, and television spots. Over the next few years, the project will expand to include a high-resolution SLR delivering real-time auroral images (also from Yellowknife), as well as a program where astronauts on the ISS will take pictures of the aurora with a handheld SLR. The objectives of AuroraMAX are public outreach and education. The ASI design, operation, and software were based on infrastructure that was developed for the highly successful ASI component of the NASA THEMIS mission as well as the Canadian Space Agency (CSA) Canadian GeoSpace Monitoring (CGSM) program. So from an education and public outreach perspective, AuroraMAX is a single camera operating in the Canadian north. On the other hand, AuroraMAX is one of nearly 40 All-Sky Imagers that are operating across North America. The AuroraMAX camera produces data that is seamlessly integrated with the CGSM ASI data, and made widely available to the Space Science community through open-access web and FTP sites. One of our objectives in the next few years is to incorporate some of the data from the THEMIS and CGSM imagers into the AuroraMAX system, to maximize viewing opportunities and generate more real-time data for public outreach. This is an exemplar of a program that

  7. Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle

    Directory of Open Access Journals (Sweden)

    Gabriele Büchel

    2017-12-01

    Full Text Available MYC proteins bind globally to active promoters and promote transcriptional elongation by RNA polymerase II (Pol II. To identify effector proteins that mediate this function, we performed mass spectrometry on N-MYC complexes in neuroblastoma cells. The analysis shows that N-MYC forms complexes with TFIIIC, TOP2A, and RAD21, a subunit of cohesin. N-MYC and TFIIIC bind to overlapping sites in thousands of Pol II promoters and intergenic regions. TFIIIC promotes association of RAD21 with N-MYC target sites and is required for N-MYC-dependent promoter escape and pause release of Pol II. Aurora-A competes with binding of TFIIIC and RAD21 to N-MYC in vitro and antagonizes association of TOP2A, TFIIIC, and RAD21 with N-MYC during S phase, blocking N-MYC-dependent release of Pol II from the promoter. Inhibition of Aurora-A in S phase restores RAD21 and TFIIIC binding to chromatin and partially restores N-MYC-dependent transcriptional elongation. We propose that complex formation with Aurora-A controls N-MYC function during the cell cycle.

  8. Aurora project: optical design for a kilojoule class KrF laser

    International Nuclear Information System (INIS)

    Hanlon, J.; McLeod, J.; Sollid, J.E.; Horn, W. III; Carmichael, R.; Kortegaard, B.; Woodfin, G.; Rosocha, L.

    1985-01-01

    Aurora is a 248-nm, 10-kilojoule laser system being built at Los Alamos National Laboratory to demonstrate the feasibility of large KrF laser systems for laser fusion. It was designed as a test bed to demonstrate: (1) efficiet energy extraction at 248 nm; (2) an angularly multiplexed optical system that is scaleable to large system designs; (3) the control of parasitics and ASE (amplified spontaneous emission); (4) long path pulse propagation at uv wavelengths; (5) alignment systems for multibeam systems; and (6) new or novel approaches to optical hardware that can lead to cost reduction on large systems. In this paper only issues pertinent to the optical system are addressed. First, a description of the entire system is given. The design constraints on the optical system are explained, concurrent with a discussion of the final design. This is followed by a very brief discussion of coatings; in particular, the use of sol-gels for antireflection coatings is presented

  9. TJ-II project

    International Nuclear Information System (INIS)

    Alejaldre, C.; Gozalo, J.J.A.; Perez, J.B.; Magaria, F.C.; Diaz, J.R.C.; Perez, J.G.; Lopez-Fraguas, A.; Garcia, L.; Krivenski, V.I.; Martin, R.; Navarro, A.P.; Perea, A.; Rodriguez-Yunta, A.; Ayza, M.S.; Varias, A.

    1990-01-01

    The TJ-II device is a medium-size helical-axis stellarator to be built in Madrid. Its main characteristics are potential for high-beta operation; flexibility, i.e., its rotational transform can be varied over a wide range and its shear to some extent; and bean-shaped plasma cross section. The latest understanding of TJ-II physics in the fields of electron cyclotron resonance heating, transport, and magneto-hydrodynamics, and the engineering solutions introduced in its final design are discussed

  10. Hovdabrekka Project II

    DEFF Research Database (Denmark)

    Hovden, Jan

    2008-01-01

    The Hovdabrekka group is a group of nordic researchers doing survey studies of Nordic journalism schools (2005,2008). This site is dedicated to information from this project. The current members are: Norway: Rune Ottosen,Gunn Bjørnsen and Jan Fredrik Hovden Sweden: Jenny Wiik Denmark: Ida Willig...... and Jannie Møller Hartley. Finland: Henrika Zilliacus-Tikkanen and Raimo Solokangas Former members: Jan Dyberg and Hanne Jørndrup (Denmark), Marina Ghersetti (Sweden) Project Hovdabrekka originated at the Nordic conference for journalist teachers at Hovdabrekka, Iceland September 2004, where a small group...... of scientists/lecturers assembled with a desire to do a comparative quantitative study of students at Nordic journalism schools. Until very recently, there existed little systematic knowledge on the students of journalism in the Nordic countries. For these reasons, the Hovdabrekka group planned and sent out...

  11. Spitzbergen - a unique site for observing aurorae

    International Nuclear Information System (INIS)

    Egeland, A.; Sandholt, P.E.

    1981-01-01

    An international research project situated on Spitzbergen was begun in 1978-79 by Norwegian, British, and American scientists. The main purpose of the project is systematic studies of midday aurorae. Midday aurorae are a new and interesting research theme for which Norway has special qualifications. Through international cooperation a comprehensive instrument park and a practical and economic distribution of tasks have been attained. (Auth./JIW)

  12. Military Family Coping Project - Phase II

    Science.gov (United States)

    2015-05-01

    Anxiety, Life Satisfaction , Addiction, Trauma 4 The Military Family Coping Project reflects two phases. The first consisted of a series of focus...need for and guided the work of the Military Family Coping Project Phase II funded by TATRC. The Military Family Coping Project Phase II was...solidarity. For the purposes of family functioning analyses, married and unmarried soldiers were analyzed separately because marital status affects

  13. Project planning and project management of Baseball II-T

    International Nuclear Information System (INIS)

    Kozman, T.A.; Chargin, A.K.

    1975-01-01

    The details of the project planning and project management work done on the Baseball II-T experiment are reviewed. The LLL Baseball program is a plasma confinement experiment accomplished with a superconducting magnet in the shape of a baseball seam. Both project planning and project management made use of the Critical Path Management (CPM) computer code. The computer code, input, and results from the project planning and project management runs, and the cost and effectiveness of this method of systems planning are discussed

  14. Project Final Report: HPC-Colony II

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Terry R [ORNL; Kale, Laxmikant V [University of Illinois, Urbana-Champaign; Moreira, Jose [IBM T. J. Watson Research Center

    2013-11-01

    This report recounts the HPC Colony II Project which was a computer science effort funded by DOE's Advanced Scientific Computing Research office. The project included researchers from ORNL, IBM, and the University of Illinois at Urbana-Champaign. The topic of the effort was adaptive system software for extreme scale parallel machines. A description of findings is included.

  15. The Sudbury Neutrino Observatory project and the Kamiokande II project

    International Nuclear Information System (INIS)

    Beier, E.W.

    1991-01-01

    This document is a technical progress report on work performed at the University of Pennsylvania during the current year on the Sudbury Neutrino Observatory project and on the Kamiokande II project. The motivation for both experiments is the measurement of neutrinos emitted by the sun. The Kamiokande II experiment was an adaptation of an existing nucleon decay detector located in Japan to search for neutrinos emitted by the sun. It has been operational since 1986. Data taking was concluded in 1990 and work will terminate at the end of this grant year. The topics discussed in this report are: the Sudbury Neutrino Observatory project; photomultiplier tube measurements; photomultiplier bases; signal processing electronics; electronics system issues; software management and development; and Kamiokande II

  16. Health Activities Project (HAP), Trial Edition II.

    Science.gov (United States)

    Buller, Dave; And Others

    Contained within this Health Activities Project (HAP) trial edition (set II) are a teacher information folio and numerous student activity folios which center around the idea that students in grades 5-8 can control their own health and safety. Each student folio is organized into a Synopsis, Health Background, Materials, Setting Up, and Activities…

  17. Theory of aurora formation

    International Nuclear Information System (INIS)

    Hasegawa, Akira.

    1975-04-01

    A new theory of aurora formation is presented based on Alfven wave-electron interaction. The theory explains consistently 1) the electron acceleration process, 2) the formation of auroral layers and 3) the long wave formation in the longitudinal direction. (auth.)

  18. Aurora energy resources

    Energy Technology Data Exchange (ETDEWEB)

    Falconer, D. [Aurora Energy Resources Inc., Vancouver, British Columbia (Canada)

    2009-07-01

    This paper describes the structure and activities of Aurora, a mining company which owns uranium mines, open pit mines at Michelin, Jacques Lake and Rainbow and underground mines at Michelin and Jacques Lake. The paper discusses issues such as economics, mining, processing and environmental impacts.

  19. Altered expression of Aurora kinases in Arabidopsis results in aneu- and polyploidization.

    Science.gov (United States)

    Demidov, Dmitri; Lermontova, Inna; Weiss, Oda; Fuchs, Joerg; Rutten, Twan; Kumke, Katrin; Sharbel, Timothy F; Van Damme, Daniel; De Storme, Nico; Geelen, Danny; Houben, Andreas

    2014-11-01

    Aurora is an evolutionary conserved protein kinase family involved in monitoring of chromosome segregation via phosphorylation of different substrates. In plants, however, the involvement of Aurora proteins in meiosis and in sensing microtubule attachment remains to be proven, although the downstream components leading to the targeting of spindle assembly checkpoint signals to anaphase-promoting complex have been described. To analyze the three members of Aurora family (AtAurora1, -2, and -3) of Arabidopsis we employed different combinations of T-DNA insertion mutants and/or RNAi transformants. Meiotic defects and the formation of unreduced pollen were revealed including plants with an increased ploidy level. The effect of reduced expression of Aurora was mimicked by application of the ATP-competitive Aurora inhibitor II. In addition, strong overexpression of any member of the AtAurora family is not possible. Only tagged or truncated forms of Aurora kinases can be overexpressed. Expression of truncated AtAurora1 resulted in a high number of aneuploids in Arabidopsis, while expression of AtAurora1-TAPi construct in tobacco resulted in 4C (possible tetraploid) progeny. In conclusion, our data demonstrate an essential role of Aurora kinases in the monitoring of meiosis in plants. © 2014 The Authors The Plant Journal © 2014 John Wiley & Sons Ltd.

  20. Status of the FRM-II project

    International Nuclear Information System (INIS)

    Boening, K.

    1994-01-01

    The new research reactor FRM-II at Garching near Munich is planned to become a high performance source of slow neutrons in Germany. Its design concept provides for a very compact reactor core cooled by light water and placed within a heavy water moderator tank, where a high thermal neutron flux will be obtained at only 20 MW power. - This paper begins with an overview over some of the essential design features and some more recent design modifications. It then reports on the status of the project, the most important event being a positive decision which the Bavarian State Government has made in January 1993 and which represented a green light for the project to enter the next project phase. Consequently, two official requests have been made by the Technical University of Munich, one for the nuclear licensing of the facility and the other for the so called 'Raumordnungsverfahren'. In this context the final version of the FRM-II safety report has been submitted to the nuclear licensing authority. (author)

  1. Final project report: TA-35 Los Alamos Power Reactor Experiment No. II (LAPRE II) decommissioning project

    International Nuclear Information System (INIS)

    Montoya, G.M.

    1993-02-01

    This final report addresses the decommissioning of the LAPRE II Reactor, safety enclosure, fuel reservoir tanks, emergency fuel recovery system, primary pump pit, secondary loop, associated piping, and the post-remediation activities. Post-remedial action measurements are also included. The cost of the project including, Phase I assessment and Phase II remediation was approximately $496K. The decommissioning operation produced 533 M 3 of mixed waste

  2. Final project report, TA-35 Los Alamos Power Reactor Experiment No. II (LAPRE II) decommissioning project

    International Nuclear Information System (INIS)

    Montoya, G.M.

    1992-01-01

    This final report addresses the decommissioning of the LAPRE II Reactor, safety enclosure, fuel reservoir tanks, emergency fuel recovery system, primary pump pit, secondary loop, associated piping, and the post-remediation activities. Post-remedial action measurements are also included. The cost of the project, including Phase I assessment and Phase II remediation was approximately $496K. The decommissioning operation produced 533 m 3 of low-level solid radioactive waste and 5 m 3 of mixed waste

  3. Combined Final Report for Colony II Project

    Energy Technology Data Exchange (ETDEWEB)

    Kale, Laxmikant [University of Illinois; Jones, Terry [Oak Ridge National Laboratory; Moreira, Jose [IBM Corp.

    2013-10-23

    (This report was originally submmited by the lead PI (Terry Jones, ORNL) on October 22, 2013 to the program manager, Lucy Nowell. It is being submitted from University of Illinois in accordance with instructions). HPC Colony II seeks to provide portable performance for leadership class machines. Our strategy is based on adaptive system software that aims to make the intelligent decisions necessary to allow domain scientists to safely focus on their task at hand and allow the system software stack to adapt their application to the underlying architecture. This report describes the research undertaken towards these objectives and the results obtained over the performance period of the project.

  4. Aurorasaurus: A citizen science platform for viewing and reporting the aurora

    Science.gov (United States)

    MacDonald, E. A.; Case, N. A.; Clayton, J. H.; Hall, M. K.; Heavner, M.; Lalone, N.; Patel, K. G.; Tapia, A.

    2015-09-01

    A new, citizen science-based, aurora observing and reporting platform has been developed with the primary aim of collecting auroral observations made by the general public to further improve the modeling of the aurora. In addition, the real-time ability of this platform facilitates the combination of citizen science observations with auroral oval models to improve auroral visibility nowcasting. Aurorasaurus provides easily understandable aurora information, basic gamification, and real-time location-based notification of verified aurora activity to engage citizen scientists. The Aurorasaurus project is one of only a handful of space weather citizen science projects and can provide useful results for the space weather and citizen science communities. Early results are promising with over 2000 registered users submitting over 1000 aurora observations and verifying over 1700 aurora sightings posted on Twitter.

  5. Drifting black aurorae?

    International Nuclear Information System (INIS)

    Schoute-Vanneck, H.; Scourfield, M.W.J.; Nielsen, E.

    1990-01-01

    Characteristics of eastward drifting forms, previously described in the literature as black aurorae, have been identified in low-light level TV camera data. The TV field of view was within the field of view of STARE and that of an all-sky camera. On the basis of these observations the authors propose that these auroral forms are a manifestation of folds or waves on the borders of auroral bands propagating along the dark regions between neighboring auroral bands. Conditions under which the folds or waves occur are compatible with their formation by the Kelvin-Helmholtz electrostatic instability

  6. Aurora laser optical system

    International Nuclear Information System (INIS)

    Hanlon, J.A.; McLeod, J.

    1987-01-01

    Aurora is the Los Alamos short-pulse high-power krypton fluoride laser system. It is primarily an end-to-end technology demonstration prototype for large-scale UV laser systems of interest for short-wavelength inertial confinement fusion (ICF) investigations. The system is designed to employ optical angular multiplexing and aerial amplification by electron-beam-driven KrF laser amplifiers to deliver to ICF targets a stack of pulses with a duration of 5 ns containing several kilojoules at a wavelength of 248 nm. A program of high-energy density plasma physics investigations is now planned, and a sophisticated target chamber was constructed. The authors describe the design of the optical system for Aurora and report its status. This optical system was designed and is being constructed in two phases. The first phase carries only through the amplifier train and does not include a target chamber or any demultiplexing. Installation should be complete, and some performance results should be available. The second phase provides demultiplexing and carries the laser light to target. The complete design is reported

  7. Aurorae in Australian Aboriginal Traditions

    Science.gov (United States)

    Hamacher, Duane W.

    2013-07-01

    Transient celestial phenomena feature prominently in the astronomical knowledge and traditions of Aboriginal Australians. In this paper, I collect accounts of the Aurora Australis from the literature regarding Aboriginal culture. Using previous studies of meteors, eclipses, and comets in Aboriginal traditions, I anticipate that the physical properties of aurora, such as their generally red colour as seen from southern Australia, will be associated with fire, death, blood, and evil spirits. The survey reveals this to be the case and also explores historical auroral events in Aboriginal cultures, aurorae in rock art, and briefly compares Aboriginal auroral traditions with other global indigenous groups, including the Maori of New Zealand.

  8. HORIZON 2020 - Project SITEX-II

    International Nuclear Information System (INIS)

    Nachmilner, L.

    2016-01-01

    In the mid of 2015 a coordination action SITEX-II was initiated within the EC programme Horizon 2020. It aims at implementing in practice activities along with the interaction models issued by the SITEX project (carried out within FP7 programme in 2012-13), in view of developing an Expertise function network. This network is expected to ensure sustainable capacity of developing and coordination joint and harmonised activities related to the independent technical expertise in the field of safety of deep geological disposal of radioactive waste. SITEX-II tasks include: • The definition of the Strategic Research Agenda (SRA) based on the common R orientations defined by SITEX, the definition of ToR for the implementation of specific topics of from the SRA, and the interaction with IGD-TP and other external entities mandated to implement research on radioactive waste disposal regarding the potential setting up of a respective European Joint Programming; • The production of a guidance on the technical review of the safety case at its different phases of development, fostering a common understanding on the interpretation and proper implementation of safety requirements for developing, operating and closing a geological repository and on then verification of compliance with these requirements; • The commitment of a Civil Society (CS) in the definition of the SRA mentioned above, considering the expectations and technical questions to be considered when developing R for the purpose of Expert function. Close interactions between experts conducting the review work and CS representatives will enhance establishing the safety culture and, more globally, proposing governance patterns with CS in the framework of geological disposal; • The preparation of the ‚administrative‘ framework for creating a sustainable network of Technical Safety Organisations from EU members states by addressing the legal organisational and management aspects. (author)

  9. Adventures in search of auroras

    Science.gov (United States)

    Forsyth, Colin

    2016-09-01

    In her book Aurora: In Search of the Northern Lights, Melanie Windridge describes travelling around the Arctic Circle on a quest to see the biggest and best auroral displays and to understand the physics that drives them.

  10. FEBEX II Project THG Laboratory Experiments

    International Nuclear Information System (INIS)

    Missana, T.

    2004-01-01

    The main roles of the bentonite in a radioactive waste repository is to act as a geochemical barrier against the radionuclides migration. The effectiveness of this geochemical barrier depends on the surface properties of the solid phases and on the physico-chemical environment generated by the interaction of the solid phases with the groundwater. Within the FEBEX (Full-scale Engineered Barriers Experiment) project, a program of laboratory tests was designed to study and to understand the processes taking place in the clay barrier. Since the first stages of the project, these laboratory tests enabled to isolate different processes, making easier their interpretation, and provided fundamental parameters to be used in the Thermo Hydro Mechanical (THM) and Thermo Hydro Geochemical (THG) models. Additionally, experimental data enabled to check the predictive capability of these models. In the second phase of the project, laboratory tests focused on all those relevant aspects not sufficiently covered during FEBEX I. Particularly, the following main objectives were proposed for the THG investigations during FEBEX II : Attainment of a reliable description of the pore water chemistry at different geochemical conditions. Identification of the different types of water present in the bentonite and to determine the amount of available water for the solute transport.Evaluation of the potential effects of the extraction pressure in the chemical composition of the water obtained by squeezing methods.Study of the effects of the exchange complex in the rheological properties of the clay.Identification and modelling of the surface processes occurring in smectite, determination of the solubility constants of smectite and the formation constants of the surface complexes.Understanding of the mechanisms involved in the sorption of different radionuclides in the bentonite. Investigation of the diffusion mechanisms of conservative neutral and anionic species to have a deeper insight on the

  11. FEBEX II Project THG Laboratory Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Missana, T.

    2004-07-01

    The main roles of the bentonite in a radioactive waste repository is to act as a geochemical barrier against the radionuclides migration. The effectiveness of this geochemical barrier depends on the surface properties of the solid phases and on the physico-chemical environment generated by the interaction of the solid phases with the groundwater. Within the FEBEX (Full-scale Engineered Barriers Experiment) project, a program of laboratory tests was designed to study and to understand the processes taking place in the clay barrier. Since the first stages of the project, these laboratory tests enabled to isolate different processes, making easier their interpretation, and provided fundamental parameters to be used in the Thermo Hydro Mechanical (THM) and Thermo Hydro Geochemical (THG) models. Additionally, experimental data enabled to check the predictive capability of these models. In the second phase of the project, laboratory tests focused on all those relevant aspects not sufficiently covered during FEBEX I. Particularly, the following main objectives were proposed for the THG investigations during FEBEX II : Attainment of a reliable description of the pore water chemistry at different geochemical conditions. Identification of the different types of water present in the bentonite and to determine the amount of available water for the solute transport.Evaluation of the potential effects of the extraction pressure in the chemical composition of the water obtained by squeezing methods.Study of the effects of the exchange complex in the rheological properties of the clay.Identification and modelling of the surface processes occurring in smectite, determination of the solubility constants of smectite and the formation constants of the surface complexes.Understanding of the mechanisms involved in the sorption of different radionuclides in the bentonite. Investigation of the diffusion mechanisms of conservative neutral and anionic species to have a deeper insight on the

  12. Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle

    DEFF Research Database (Denmark)

    Büchel, Gabriele; Carstensen, Anne; Mak, Ka-Yan

    2017-01-01

    MYC proteins bind globally to active promoters and promote transcriptional elongation by RNA polymerase II (Pol II). To identify effector proteins that mediate this function, we performed mass spectrometry on N-MYC complexes in neuroblastoma cells. The analysis shows that N-MYC forms complexes...

  13. Impact of National Fadama Development Project II on Rice farmers ...

    African Journals Online (AJOL)

    ... examined the impact of National Fadama Development Project II on the profitability of rice farmers and assessed the extent to which the various innovations disseminated by the project were adopted by the rice farmer beneficiaries. The project which had all operating expenses cofinanced by the various key stakeholders ...

  14. The Aurora space launcher concept

    Science.gov (United States)

    Kopp, Alexander; Stappert, Sven; Mattsson, David; Olofsson, Kurt; Marklund, Erik; Kurth, Guido; Mooij, Erwin; Roorda, Evelyne

    2017-11-01

    This paper gives an overview about the Aurora reusable space launcher concept study that was initiated in late-2015/early-2016. Within the Aurora study, several spaceplane-like vehicle configurations with different geometries, propulsion systems and mission profiles will be designed, investigated and evaluated with respect to their technical and economic feasibility. The first part of this paper will discuss the study logic and the current status of the Aurora studies and introduces the first vehicle configurations and their system design status. As the identification of highly efficient structural designs is of particular interest for Aurora, the structural design and analysis approach will be discussed in higher level of detail. A special design feature of the Aurora vehicle configurations is the utilization of the novel thin-ply composite material technology for structural mass reductions. Therefore, the second part of this paper will briefly discuss this technology and investigate the application and potential mass savings on vehicle level within simplified structural analysis studies. The results indicate that significant mass savings could be possible. Finally, an outlook on the next steps is provided.

  15. The Aurora space launcher concept

    Science.gov (United States)

    Kopp, Alexander; Stappert, Sven; Mattsson, David; Olofsson, Kurt; Marklund, Erik; Kurth, Guido; Mooij, Erwin; Roorda, Evelyne

    2018-06-01

    This paper gives an overview about the Aurora reusable space launcher concept study that was initiated in late-2015/early-2016. Within the Aurora study, several spaceplane-like vehicle configurations with different geometries, propulsion systems and mission profiles will be designed, investigated and evaluated with respect to their technical and economic feasibility. The first part of this paper will discuss the study logic and the current status of the Aurora studies and introduces the first vehicle configurations and their system design status. As the identification of highly efficient structural designs is of particular interest for Aurora, the structural design and analysis approach will be discussed in higher level of detail. A special design feature of the Aurora vehicle configurations is the utilization of the novel thin-ply composite material technology for structural mass reductions. Therefore, the second part of this paper will briefly discuss this technology and investigate the application and potential mass savings on vehicle level within simplified structural analysis studies. The results indicate that significant mass savings could be possible. Finally, an outlook on the next steps is provided.

  16. Aurora status and plans

    International Nuclear Information System (INIS)

    Kristal, R.; Blair, L.S.; Burrows, M.D.

    1987-10-01

    Aurora is a short wavelength (248 nm) 10 to kJ KrF laser systems in the ICF program at Los Alamos National Laboratory. It is both an experiment in driver technology and a means for studying target performance using KrF laser light. Both features will be used to help evaluate the uv excimer laser as a viable fusion driver. The system has been designed to employ several electron-beam pumped amplifiers in series, with a final aperture of one meter square, to amplify 96 angularly mulitplexed 5 ns beamlets to the 10 kJ level. In Phase I, 48 of these beamlets are brought to target by demultiplexing and focusing with f26 optics. The beamlet ensemble, contained within an f1.9 bundle, is focused as a single beam;however, pointing is done individually. Spot size in the target plane is variable from 0.1-4 mm, with maximum averaged intensity of /similar to/ 4 x 10 15 Wcm 2 . The illumination geometry is designed specifically for several classes of important target physics experiments. These include: energy flow, symmetry and preheat studies related to indirectly driven targets;x-ray conversion and plasma coupling characterization on disc targets, and hydrodynamic instability studies in planar geometry. System integration is proceeding toward initial target experiments in /similar to/ late 1988. Ninety-six beam amplification through the penultimate amplifier has been obtained at the sub-kJ level. Installation of beam train optics is proceeding, and the target system vacuum envelope is in place. 18 refs., 12 figs., 2 tabs

  17. Lifts of projective congruence groups, II

    DEFF Research Database (Denmark)

    Kiming, Ian

    2014-01-01

    We continue and complete our previous paper ``Lifts of projective congruence groups'' concerning the question of whether there exist noncongruence subgroups of  that are projectively equivalent to one of the groups  or . A complete answer to this question is obtained: In case of  such noncongruence...

  18. Targeting Aurora B to the equatorial cortex by MKlp2 is required for cytokinesis.

    Directory of Open Access Journals (Sweden)

    Mayumi Kitagawa

    Full Text Available Although Aurora B is important in cleavage furrow ingression and completion during cytokinesis, the mechanism by which kinase activity is targeted to the cleavage furrow and the molecule(s responsible for this process have remained elusive. Here, we demonstrate that an essential mitotic kinesin MKlp2 requires myosin-II for its localization to the equatorial cortex, and this event is required to recruit Aurora B to the equatorial cortex in mammalian cells. This recruitment event is also required to promote the highly focused accumulation of active RhoA at the equatorial cortex and stable ingression of the cleavage furrow in bipolar cytokinesis. Specifically, in drug-induced monopolar cytokinesis, targeting Aurora B to the cell cortex by MKlp2 is essential for cell polarization and furrow formation. Once the furrow has formed, MKlp2 further recruits Aurora B to the growing furrow. This process together with continuous Aurora B kinase activity at the growing furrow is essential for stable furrow propagation and completion. In contrast, a MKlp2 mutant defective in binding myosin-II does not recruit Aurora B to the cell cortex and does not promote furrow formation during monopolar cytokinesis. This mutant is also defective in maintaining the ingressing furrow during bipolar cytokinesis. Together, these findings reveal that targeting Aurora B to the cell cortex (or the equatorial cortex by MKlp2 is essential for the maintenance of the ingressing furrow for successful cytokinesis.

  19. Sears Point Tidal Marsh Restoration Project: Phase II

    Science.gov (United States)

    Information about the SFBWQP Sears Point Tidal Marsh Restoration Project: Phase II, part of an EPA competitive grant program to improve SF Bay water quality focused on restoring impaired waters and enhancing aquatic resources.

  20. LHC related projects and studies - Part (II)

    International Nuclear Information System (INIS)

    Rossi, L.; De Maria, R.

    2012-01-01

    The session was devoted to address some aspects of the HL-LHC (High Luminosity LHC) project and explore ideas on new machines for the long term future. The session had two parts. The former focused on some of the key issues of the HL-LHC projects: beam current limits, evolution of the collimation system, research plans for the interaction region magnets and crab cavities. The latter explored the ideas for the long term future projects (LHeC and HE-LHC) and how the current research-development program for magnets and RF structures could fit in the envisaged scenarios

  1. Image analysis of dayside aurora

    International Nuclear Information System (INIS)

    Lybekk, B.

    1989-12-01

    Ground based observations from Svalbard of the midday aurora by all sky cameras and meridian scanning photometers showed the sporadic occurrence of discrete auroral forms within or near the stable cusp or cleft aurora. Some of these forms appeared near the equatorward boundary of the stable cusp/cleft aurora and moved westward and northward. The duration of the whole event was typically less than 10 minutes. Series of such events were observed when the cusp/cleft was located at low latitudes. Satellite measurements of magnetic field and ion drift components above auroral strucures gave detailed information of auroral electrodynamics in the cusp/cleft ionosphere. Satellite observations of the dayside oval at ∼ 09 MLT showed that auroral emissions can be separated in different latitudinal zones with corresponding structures in the particle precipitation. The ground based optical instruments at Svalbard measured the stationary cleft aurora produced by soft electrons and transient discrete arcs produced by precipitating keV electrons. 89 refs

  2. EBR-II and TREAT Digitization Project

    Energy Technology Data Exchange (ETDEWEB)

    Griffith, George W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rabiti, Cristian [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-09-01

    Digitizing the technical drawings for EBR-II and TREAT provides multiple benefits. Moving the scanned or hard copy drawings to modern 3-D CAD (Computer Aided Drawing) format saves data that could be lost over time. The 3-D drawings produce models that can interface with other drawings to make complex assemblies. The 3-D CAD format can also include detailed material properties and parametric coding that can tie critical dimensions together allowing easier modification. Creating the new files from the old drawings has found multiple inconsistencies that are being flagged or corrected improving understanding of the reactor(s).

  3. EBR-II and TREAT Digitization Project

    International Nuclear Information System (INIS)

    Griffith, George W.; Rabiti, Cristian

    2015-01-01

    Digitizing the technical drawings for EBR-II and TREAT provides multiple benefits. Moving the scanned or hard copy drawings to modern 3-D CAD (Computer Aided Drawing) format saves data that could be lost over time. The 3-D drawings produce models that can interface with other drawings to make complex assemblies. The 3-D CAD format can also include detailed material properties and parametric coding that can tie critical dimensions together allowing easier modification. Creating the new files from the old drawings has found multiple inconsistencies that are being flagged or corrected improving understanding of the reactor(s).

  4. Status of the DESY II project

    International Nuclear Information System (INIS)

    Hemmie, G.

    1987-01-01

    DESY II has been extensively tested at low magnet current excitations corresponding to 1 GeV maximum energy. After the old DESY I synchrotron was turned off in Nov. 86 the provisional power supplies were replaced by magnet- and rf-power supplies of full 8 GeV rating. All external beam lines have now been connected to the new machine. Some modifications on components are described. A report on the results from the initial tests of the machine under full power conditions is given

  5. Optical aurora detectors: using natural optics to motivate education and outreach

    Science.gov (United States)

    Shaw, Joseph A.; Way, Jesse M.; Pust, Nathan J.; Nugent, Paul W.; Coate, Hans; Balster, Daniel

    2009-06-01

    Natural optical phenomena enjoy a level of interest sufficiently high among a wide array of people to provide ideal education and outreach opportunities. The aurora promotes particularly high interest, perhaps because of its relative rarity in the areas of the world where most people live. A project is being conducted at Montana State University to use common interest and curiosity about auroras to motivate learning and outreach through the design and deployment of optical sensor systems that detect the presence of an auroral display and send cell phone messages to alert interested people. Project participants learn about the physics and optics of the aurora, basic principles of optical system design, radiometric calculations and calibrations, electro-optical detectors, electronics, embedded computer systems, and computer software. The project is moving into a stage where it will provide greatly expanded outreach and education opportunities as optical aurora detector kits are created and disbursed to colleges around our region.

  6. TA 55 Reinvestment Project II Phase C Update Project Status May 23, 2017

    Energy Technology Data Exchange (ETDEWEB)

    Giordano, Anthony P. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-05-25

    The TA-55 Reinvestment Project (TRP) II Phase C is a critical infrastructure project focused on improving safety and reliability of the Los Alamos National Laboratory (LANL) TA-55 Complex. The Project recapitalizes and revitalizes aging and obsolete facility and safety systems providing a sustainable nuclear facility for National Security Missions.

  7. Project management at Heysham II and Torness

    International Nuclear Information System (INIS)

    Taylor, D.

    1987-01-01

    The National Nuclear Corporation (NNC) have contracts from the Central Electricity Generating Board (CEGB) and the South of Scotland Electricity Board (SSEB) for the design and construction of the AGR Nuclear Power Stations at Heysham II and Torness. Within these contracts, procurement and construction of the various components making up the Nuclear Island are managed by NNC as agents of the two generating boards. Other responsibilities are for the design of the whole station, preparation of the safety case and on-site management of the Nuclear Island at both stations. Additional responsibilities are included in the Torness contract such that NNC manage almost the whole of the site works. Construction of both stations started in August 1980 and power raising is expected to commence on time at the end of this year. Both stations are close to the original budget. This paper examines factors which have contributed to this success including the relationship between NNC, the contractors, clients and the safety authority. (author)

  8. Brazilian Decimetric Array (BDA) project - Phase II

    Science.gov (United States)

    Faria, C.; Stephany, S.; Sawant, H. S.; Cecatto, J. R.; Fernandes, F. C. R.

    2010-02-01

    The configuration of the second phase of the Brazilian Decimetric Array (BDA), installed at Cachoeira Paulista, Brazil (Longitude 45° 0‧ 20″ W and Latitude 22° 41‧ 19″ S), is a T-shaped array where 21 antennas are being added to existing 5 antennas of the first phase. In the third phase, in each arm of the T array, four more antennas will be added and baselines will be increased to 2.5 × 1.25 km in east-west and south directions, respectively. The antennas will be equally spaced at the distances of 250 meters from the central antenna of the T-array. Also, the frequency range will be increased to 1.2-1.7, 2.8 and 5.6 GHz. The Second phase of the BDA should be operational by the middle of 2010 and will operate in the frequency range of (1.2-1.7) GHz for solar and non solar observations. Here, we present the characteristics of the second phase of the BDA project, details of the array configuration, the u-v coverage, the synthesized beam obtained for the proposed configuration.

  9. A status report on the PBFA II construction project

    International Nuclear Information System (INIS)

    Barr, G.W.; Furaus, J.P.; Cook, D.L.; Shirley, C.G.

    1985-01-01

    The Particle Beam Fusion Accelerator II (PBFA II) is under construction at Sandia National Laboratories (SNL). PBFA II contains 36 individual power modules configured in a stacked radial geometry and synchronized to provide greater than 3.5 MJ of energy into the vacuum section in a single 55-ns-wide 90-TW peak power pulse. This R and D construction project is being implemented in a fast track schedule mode in which final design of the accelerator components occurs in parallel with the construction of the laboratory building and the accelerator tank. PBFA II is scheduled to become operational in January 1986 with its first multi-module shot into an applied-B ion diode that will generate and transport a beam of lithium ions. Plans are now being made for experimental work on PBFA II beyond the construction phase

  10. Aurora oil switch upgrade program

    International Nuclear Information System (INIS)

    Warren, T.

    1989-03-01

    This report describes the short pulse synchronization requirements, the original Aurora trigger scheme, and the PI/SNLA approach to improving the synchronization. It also describes the oil switching design study undertaken as the first phase of the program. A discussion of oil-switch closure analysis and the conceptual design motivated by this analysis are presented. This paper also describes the oil-switch trigger pulser tests required to validate the concept. This includes the design of the testing facility, a description of the test goals, and a discussion of the results. This paper finally describes oil-switch trigger pulser testing on one of the four Aurora Blumlein modules, which includes the hardware design and operation, the testing goals, hardware installation, and test results. 9 refs., 26 figs

  11. Hydrogeology baseline study Aurora Mine

    International Nuclear Information System (INIS)

    1996-01-01

    A baseline hydrogeologic study was conducted in the area of Syncrude's proposed Aurora Mine in order to develop a conceptual regional hydrogeologic model for the area that could be used to understand groundwater flow conditions. Geologic information was obtained from over 2,000 coreholes and from data obtained between 1980 and 1996 regarding water level for the basal aquifer. A 3-D numerical groundwater flow model was developed to provide quantitative estimates of the potential environmental impacts of the proposed mining operations on the groundwater flow system. The information was presented in the context of a regional study area which encompassed much of the Athabasca Oil Sands Region, and a local study area which was defined by the lowlands of the Muskeg River Basin. Characteristics of the topography, hydrology, climate, geology, and hydrogeology of the region are described. The conclusion is that groundwater flow in the aquifer occurs mostly in a westerly direction beneath the Aurora Mine towards its inferred discharge location along the Athabasca River. Baseflow in the Muskeg River is mostly related to discharge from shallow surficial aquifers. Water in the river under baseflow conditions was fresh, of calcium-carbonate type, with very little indication of mineralization associated with deeper groundwater in the Aurora Mine area. 44 refs., 5 tabs., 31 figs

  12. Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC

    International Nuclear Information System (INIS)

    Lin, Zhong-Zhe; Jeng, Yung-Ming; Hu, Fu-Chang; Pan, Hung-Wei; Tsao, Hsin-Wei; Lai, Po-Lin; Lee, Po-Huang; Cheng, Ann-Lii; Hsu, Hey-Chi

    2010-01-01

    To investigate the significance of Aurora B expression in hepatocellular carcinoma (HCC). The Aurora B and Aurora A mRNA level was measured in 160 HCCs and the paired nontumorous liver tissues by reverse transcription-polymerase chain reaction. Mutations of the p53 and β-catenin genes were analyzed in 134 and 150 tumors, respectively, by direct sequencing of exon 2 to exon 11 of p53 and exon 3 of β-catenin. Anticancer effects of AZD1152-HQPA, an Aurora B kinase selective inhibitor, were examined in Huh-7 and Hep3B cell lines. Aurora B was overexpressed in 98 (61%) of 160 HCCs and in all 7 HCC cell lines examined. The overexpression of Aurora B was associated with Aurora A overexpression (P = 0.0003) and p53 mutation (P = 0.002) and was inversely associated with β-catenin mutation (P = 0.002). Aurora B overexpression correlated with worse clinicopathologic characteristics. Multivariate analysis confirmed that Aurora B overexpression was an independent poor prognostic factor, despite its interaction with Aurora A overexpression and mutations of p53 and β-catenin. In Huh-7 and Hep3B cells, AZD1152-HQPA induced proliferation blockade, histone H3 (Ser10) dephosphorylation, cell cycle disturbance, and apoptosis. Aurora B overexpression is an independent molecular marker predicting tumor invasiveness and poor prognosis of HCC. Aurora B kinase selective inhibitors are potential therapeutic agents for HCC treatment

  13. Aurora kinase A controls meiosis I progression in mouse oocytes

    Czech Academy of Sciences Publication Activity Database

    Šašková, Adéla; Šolc, Petr; Baran, V.; Kubelka, Michal; Schultz, R. M.; Motlík, Jan

    2008-01-01

    Roč. 7, č. 15 (2008), s. 2368-2376 ISSN 1538-4101 R&D Projects: GA ČR GA305/06/1413; GA ČR GD204/05/H023 Institutional research plan: CEZ:AV0Z50450515 Keywords : aurora-A * MTOC * CDK1 Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.120, year: 2008 www.landesbioscience.com/journals/cc/article/6361

  14. A ProCoS II Project Final Report: ESPRIT Basic Research project 707

    DEFF Research Database (Denmark)

    Bowen, J. P.; Hoare, C. A. R.; Langmaack, Hans

    1996-01-01

    An overview of the research and associated activities of the Europeancollaborative ESPRIT Basic Research ProCoS II project (no. 7071) on``Provably Correct Systems'' which ran from 1992 to 1995 is presented.This was a follow-on project to ProCoS (no. 3104) and ran inparallel with the ProCoS Working...

  15. Double layers above the aurora

    International Nuclear Information System (INIS)

    Temerin, M.; Mozer, F.S.

    1987-01-01

    Two different kinds of double layers were found in association with auroral precipitation. One of these is the so-called electrostatic shock, which is oriented at an oblique angle to the magnetic field in such a way that the perpendicular electric field is much larger than the parallel electric field. This type of double layer is often found at the edges of regions of upflowing ion beams and the direction of the electric fields in the shock points toward the ion beam. The potential drop through the shock can be several kV and is comparable to the total potential needed to produce auroral acceleration. Instabilities associated with the shock may generate obliquely propagating Alfven waves, which may accelerate electrons to produce flickering auroras. The flickering aurora provides evidence that the electrostatic shock may have large temporal fluctuations. The other kind of double layer is the small-amplitude double layer found in regions of upward flowing in beams, often in association with electrostatic ion cyclotron waves. The parallel and perpendicular electric fields in these structures are comparable in magnitude. The associated potentials are a few eV. Since many such double layers are found in regions of upward flowing ion beams, the combined potential drop through a set of these double layers can be substantial

  16. MANHATTAN DISTRICT HISTORY PROJECT Y THE LOS ALAMOS PROJECT VOL. II AUGUST 1945 THROUGH DECEMBER 1946

    Energy Technology Data Exchange (ETDEWEB)

    Truslow, E. C.; Smith, R. C.

    1961-12-01

    THESE TWO VOLUMES CONSTITUTE A RECORD OF THE TECHNICAL, ADMINISTRATIVE , AND POLICY-MAKING ACTIVITIES OF THE LOS ALAMOS PROJECT (PROJECT Y) FROM ITS INCEPTION UNDER THE MANHATTAN DISTRICT THROUGH THE DEVELOPMENT OF THE ATOMIC BOMB (VOL. I), AND DURING THE PERIOD FOLLOWING THE END OF WORLD WAR II UNTIL THE MANHATTAN DISTRICT RELINQUISHED CONTROL TO THE ATOMIC ENERGY COMMISSION AS OF JANUARY 1947 (VOL. II). ALTHOUGH SEC URITY REGULATIONS HAVE REQUIRED SOME DELETIONS IN THE ORIGINAL TEXT OF THE TWO VOLUMES, EVERY EFFORT HAS BEEN MADE TO RETAIN THE ORIGINAL LANGUGAGE AND EXPERSSIONS OF THE AUTHORS.

  17. Occurrence and average behavior of pulsating aurora

    Science.gov (United States)

    Partamies, N.; Whiter, D.; Kadokura, A.; Kauristie, K.; Nesse Tyssøy, H.; Massetti, S.; Stauning, P.; Raita, T.

    2017-05-01

    Motivated by recent event studies and modeling efforts on pulsating aurora, which conclude that the precipitation energy during these events is high enough to cause significant chemical changes in the mesosphere, this study looks for the bulk behavior of auroral pulsations. Based on about 400 pulsating aurora events, we outline the typical duration, geomagnetic conditions, and change in the peak emission height for the events. We show that the auroral peak emission height for both green and blue emission decreases by about 8 km at the start of the pulsating aurora interval. This brings the hardest 10% of the electrons down to about 90 km altitude. The median duration of pulsating aurora is about 1.4 h. This value is a conservative estimate since in many cases the end of event is limited by the end of auroral imaging for the night or the aurora drifting out of the camera field of view. The longest durations of auroral pulsations are observed during events which start within the substorm recovery phases. As a result, the geomagnetic indices are not able to describe pulsating aurora. Simultaneous Antarctic auroral images were found for 10 pulsating aurora events. In eight cases auroral pulsations were seen in the southern hemispheric data as well, suggesting an equatorial precipitation source and a frequent interhemispheric occurrence. The long lifetimes of pulsating aurora, their interhemispheric occurrence, and the relatively high-precipitation energies make this type of aurora an effective energy deposition process which is easy to identify from the ground-based image data.

  18. A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia.

    Science.gov (United States)

    Vormoor, B; Veal, G J; Griffin, M J; Boddy, A V; Irving, J; Minto, L; Case, M; Banerji, U; Swales, K E; Tall, J R; Moore, A S; Toguchi, M; Acton, G; Dyer, K; Schwab, C; Harrison, C J; Grainger, J D; Lancaster, D; Kearns, P; Hargrave, D; Vormoor, J

    2017-06-01

    Aurora kinases regulate mitosis and are commonly overexpressed in leukemia. This phase I/IIa study of AT9283, a multikinase inhibitor, was designed to identify maximal tolerated doses, safety, pharmacokinetics, and pharmacodynamic activity in children with relapsed/refractory acute leukemia. The trial suffered from poor recruitment and terminated early, therefore failing to identify its primary endpoints. AT9283 caused tolerable toxicity, but failed to show clinical responses. Future trials should be based on robust preclinical data that provide an indication of which patients may benefit from the experimental agent, and recruitment should be improved through international collaborations and early combination with established treatment strategies. © 2016 Wiley Periodicals, Inc.

  19. Dynamics of the dayside aurora

    International Nuclear Information System (INIS)

    Creutzberg, F.; Mcewen, D.J.

    1982-01-01

    A clearer picture of the dynamical nature of the post-noon aurora has been obtained with instrumental studies during rocket flights over the Northwest Territories of Canada. A sequence of meridian scans showing the measured intensities of the emissions along the meridian from south to north is presented. An all-sky picture of an auroral event is presented which shows a very narrow arc running through the zenith in an east-west direction, typical of many occurring during the period 1-3 hrs after local magnetic noon. A contemporaneous meridian scan taken over the same location shows a narrow spike in the zenith. The frequent occurrence of these narrow, transient auroral arcs with lifetimes of 1-2 minutes, resulting from inverted V events, is discussed

  20. The mechanism of pulsating aurora

    International Nuclear Information System (INIS)

    Johnstone, A.D.

    1983-01-01

    New measurement using ground-based techniques, sounding-rockets and geostationary satellites show that pulsating aurora is almost certainly caused by a modulation of the precipitating electron beam. The modulation is probably imposed near the magnetic equator by an interaction with ELF waves which are observed to be modulated at the same frequency. The measured wave intensity is not strong enough to cause pulsations by variation of the rate of pitch angle diffusion so it is suggested that the pulsation is caused by a coherent interaction involving the generation of ELF chorus. The periodicity arises because the chorus is shut-off after approximately half a bounce period when the increased rate of precipitation removes most of the resonant electrons. The supply is then replenished by pitch angle diffusion

  1. Aurora Bertrana: bringing "otherness" home

    Directory of Open Access Journals (Sweden)

    M. Pilar Godayol i Nogué

    2008-01-01

    Full Text Available “Decidida a viure al preu que sigui” underscores contemporary writer Maria-Antònia Oliver in her prologue to Aurora Bertrana’s fourth book, El Marroc sensual i fanàtic (1936. The urge to travel, to explore the world and to slake her thirst for new experiences shaped much of the personality and the work of this Girona-born writer. Taking her own travels as a starting point, Bertrana distinguished herself in the genre of travel writing on exotic countries, which at that time underwent a significant revival in Catalonia. Bertrana’s originality lies partly in the image of the woman traveller that she consciously cultivated for herself, and partly in the way she narrates her travels. This article seeks to recover this author and make visible her singular way of presenting otherness.

  2. The PEP-II project-wide database

    International Nuclear Information System (INIS)

    Chan, A.; Calish, S.; Crane, G.; MacGregor, I.; Meyer, S.; Wong, J.

    1995-05-01

    The PEP-II Project Database is a tool for monitoring the technical and documentation aspects of this accelerator construction. It holds the PEP-II design specifications, fabrication and installation data in one integrated system. Key pieces of the database include the machine parameter list, magnet and vacuum fabrication data. CAD drawings, publications and documentation, survey and alignment data and property control. The database can be extended to contain information required for the operations phase of the accelerator and detector. Features such as viewing CAD drawing graphics from the database will be implemented in the future. This central Oracle database on a UNIX server is built using ORACLE Case tools. Users at the three collaborating laboratories (SLAC, LBL, LLNL) can access the data remotely, using various desktop computer platforms and graphical interfaces

  3. Aurora Police Lieutenant Gains Intelligence Insight

    OpenAIRE

    Center for Homeland Defense and Security

    2012-01-01

    Center for Homeland Defense and Security, PRESS RELEASES Aurora (Colo.) Police Lt. Sam McGhee has served numerous traditional roles in law enforcement such as emergency services coordinator, media relations manager, narcotics and intelligence commander and sector commander. Currently,...

  4. The continual fuel management modification in Qinshan project II

    International Nuclear Information System (INIS)

    Ye Guodong; Pan Zefei; Zhang Xingtian

    2010-01-01

    The fuel management strategy is the basis of the nuclear power plants. The performance of the fuel management strategy affects the plants' safety and economy indicators directly. The paper summarizes all the modifications on the fuel management work in Qinshan Project II since the plant was established. It includes the surveillance system of physics tests, fetching in high performance fuel assemblies, reloading pattern optimization, and the modifications of the final safety analysis report. At the same time, it evaluates the benefit of the modifications in the few years. The experience in this paper is much helpful and could be implemented on the same type plants. (authors)

  5. Test Plan for Hydrogen Getters Project - Phase II

    International Nuclear Information System (INIS)

    Mroz, G.

    1999-01-01

    Hydrogen levels in many transuranic (TRU) waste drums are above the compliance threshold, therefore deeming the drums non-shippable to the Waste Isolation Pilot Plant (WIPP). Hydrogen getters (alkynes and dialkynes) are known to react irreversibly with hydrogen in the presence of certain catalysts. The primary purpose of this investigation is to ascertain the effectiveness of a hydrogen getter in an environment that contains gaseous compounds commonly found in the headspace of drums containing TRU waste. It is not known whether the volatile organic compounds (VOCs) commonly found in the headspace of TRU waste drums will inhibit (''poison'') the effectiveness of the hydrogen getter. The result of this study will be used to assess the feasibility of a hydrogen-getter system, which is capable of removing hydrogen from the payload containers or the Transuranic Package Transporter-II (TRUPACT-II) inner containment vessel to increase the quantity of TRU waste that can be shipped to the WIPP. Phase II for the Hydrogen Getters Project will focus on four primary objectives: Conduct measurements of the relative permeability of hydrogen and chlorinated VOCs through Tedlar (and possibly other candidate packaging materials) Test alternative getter systems as alternatives to semi-permeable packaging materials. Candidates include DEB/Pd/Al2O3 and DEB/Cu-Pd/C. Develop, test, and deploy kinetic optimization model Perform drum-scale test experiments to demonstrate getter effectiveness

  6. DECOVALEX II PROJECT Technical Report - Task 2C

    International Nuclear Information System (INIS)

    Jing, L.; Stephansson, O.; Chijimatzu, M.; Tsang, C.F.

    1999-05-01

    The DECOVALEX II project is an international co-operative research project supported by a number of national radioactive waste management organizations of different countries. The project studied four tasks: Task 1: numerical simulation of the RCF3 pump test at Sellafield, UK; Task 2: numerical simulation of the in situ T-H-M experiment at Kamaishi Mine, Japan; Task 3: monitoring of current development in rock fracture research; and Task 4: report on treatment of T-H-M processes in Performance Assessment works for nuclear waste repositories. The project started in 1995 and is scheduled to be finalised in March, 1999. This report concerns the Task 2 of the DECOVALEX H project. Task 2 of the DECOVALEX II project is the numerical modelling of the in-situ T-H-M experiment of a fractured rock - buffer - heater system at Kamaishi Mine, Japan. The experiment was carried out inside a test pit drilled in the floor of a 5 x 7 m alcove excavated near an existing drift at the 550 m level. The test pit has a circular cross section of diameter 1.7 m and a depth of 5 m, filled with bentonite which contains an electric heater. Four research teams studied Task 2 with different computational models. The task is divided into three sub-tasks: Task 2A, Task 2B and Task 2C. Task 2A was defined as a blind prediction to the coupled hydro-mechanical behaviour of the fractured rocks due to the excavation of the test pit. The calibration of the numerical models against measured results of pore pressures, flow rates and rock deformation before filling up of the test pit formed Task 2B. These two sub-tasks were performed to establish well calibrated fields of hydraulic conductivity and mechanical deformability of the fractured rocks at the test site. They were necessary for further simulations on interactions between the rock and buffer materials during heating experiments, as required for Task 2C, with a higher level of confidence on rock mass models. Presented in this report is the

  7. DECOVALEX II PROJECT Technical Report - Task 2C

    Energy Technology Data Exchange (ETDEWEB)

    Jing, L.; Stephansson, O. [Royal Inst. of Tech., Stockholm (Sweden). Dept. of Civil and Environmental Engineering; Boergesson, L. [Clay Technology AB, IDEON Research Center, Lund (Sweden); Chijimatzu, M. [Japan Nuclear Cycle Development Inst., Ibaraki (Japan). Waste Management and Fuel Cycle Research Center; Kautsky, F. [Swedish Nuclear Power Inspectorate (SKI), Stockholm (Sweden); Tsang, C.F. [Lawrence Berkeley National Laboratory, Berkeley, CA (United States). Earth Science Div.

    1999-05-01

    The DECOVALEX II project is an international co-operative research project supported by a number of national radioactive waste management organizations of different countries. The project studied four tasks: Task 1: numerical simulation of the RCF3 pump test at Sellafield, UK; Task 2: numerical simulation of the in situ T-H-M experiment at Kamaishi Mine, Japan; Task 3: monitoring of current development in rock fracture research; and Task 4: report on treatment ofT-H-M processes in Performance Assessment works for nuclear waste repositories. The project started in 1995 and is scheduled to be finalised in March, 1999. This report concerns the Task 2 of the DECOVALEX H project. Task 2 of the DECOVALEX II project is the numerical modelling of the in-situ T-H-M experiment of a fractured rock - buffer - heater system at Kamaishi Mine, Japan. The experiment was carried out inside a test pit drilled in the floor of a 5 x 7 m alcove excavated near an existing drift at the 550 m level. The test pit has a circular cross section of diameter 1.7 m and a depth of 5 m, filled with bentonite which contains an electric heater. Four research teams studied Task 2 with different computational models. The task is divided into three sub-tasks: Task 2A, Task 2B and Task 2C. Task 2A was defined as a blind prediction to the coupled hydro-mechanical behaviour of the fractured rocks due to the excavation of the test pit. The calibration of the numerical models against measured results of pore pressures, flow rates and rock deformation before filling up of the test pit formed Task 2B. These two sub-tasks were performed to establish well calibrated fields of hydraulic conductivity and mechanical deformability of the fractured rocks at the test site. They were necessary for further simulations on interactions between the rock and buffer materials during heating experiments, as required for Task 2C, with a higher level of confidence on rock mass models. Presented in this report is the definition

  8. Hubble Images Reveal Jupiter's Auroras

    Science.gov (United States)

    1996-01-01

    These images, taken by the Hubble Space Telescope, reveal changes in Jupiter's auroral emissions and how small auroral spots just outside the emission rings are linked to the planet's volcanic moon, Io. The images represent the most sensitive and sharply-detailed views ever taken of Jovian auroras.The top panel pinpoints the effects of emissions from Io, which is about the size of Earth's moon. The black-and-white image on the left, taken in visible light, shows how Io and Jupiter are linked by an invisible electrical current of charged particles called a 'flux tube.' The particles - ejected from Io (the bright spot on Jupiter's right) by volcanic eruptions - flow along Jupiter's magnetic field lines, which thread through Io, to the planet's north and south magnetic poles. This image also shows the belts of clouds surrounding Jupiter as well as the Great Red Spot.The black-and-white image on the right, taken in ultraviolet light about 15 minutes later, shows Jupiter's auroral emissions at the north and south poles. Just outside these emissions are the auroral spots. Called 'footprints,' the spots are created when the particles in Io's 'flux tube' reach Jupiter's upper atmosphere and interact with hydrogen gas, making it fluoresce. In this image, Io is not observable because it is faint in the ultraviolet.The two ultraviolet images at the bottom of the picture show how the auroral emissions change in brightness and structure as Jupiter rotates. These false-color images also reveal how the magnetic field is offset from Jupiter's spin axis by 10 to 15 degrees. In the right image, the north auroral emission is rising over the left limb; the south auroral oval is beginning to set. The image on the left, obtained on a different date, shows a full view of the north aurora, with a strong emission inside the main auroral oval.The images were taken by the telescope's Wide Field and Planetary Camera 2 between May 1994 and September 1995.This image and other images and data

  9. Emission projections 2008-2012 versus national allocation plans II

    International Nuclear Information System (INIS)

    Neuhoff, Karsten; Ferrario, Federico; Grubb, Michael; Gabel, Etienne; Keats, Kim

    2006-01-01

    We compare the national allocation plans (NAPs), proposed and submitted by EU Member States as of October 2006, with our estimations for CO 2 emissions by the installations covered by these NAPs. The collective allocations proposed under phase II NAPs exceed the historic trend of emissions extrapolated forward. Using our projections we find, depending on uncertainty in fuel prices, economic growth rates, performance of the non-power sector and CDM/JI availability, a 15% chance of a 'dead market' with emissions below cap even at zero prices. With an expected inflow of committed CDM/JI credits of 100 MtCO 2 /year, allowance supply will exceed demand in 50% of cases without any carbon price, and in 80% of our euros20/tCO 2 scenarios. Banking of allowances towards post-2012 conditions could create additional demand, but this is difficult to anticipate and conditional on policy evolution. The proposed phase II NAPs would result in low prices and only small volumes of CDM/JI would enter the EU ETS. CDM/JI would almost exclusively be public-sector funded, placing the cost of Kyoto compliance entirely upon governments. (Author)

  10. The PEP-II Project: Low-Energy Ring Design and Project Status

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2006-01-01

    We describe the present status of the PEP-II project. The project comprises four major systems: Injector, High-Energy Ring (HER), Low-Energy Ring (LER), and Interaction Region (IR). We focus in detail on the design of the LER, as its parameters and requirements are most closely related to those required for the Beijing Tau-Charm Factory rings. The PEP-II LER is a high-current, 3.1-GeV positron ring mounted above the 9-GeV HER. The LER uses a wiggler located in one of its six straight sections to provide emittance control and additional damping. We describe the rather complicated IR, which must transport the LER beam into the plane of the HER, focus it to a common beam size, and separate the beams after the head-on collisions. Both permanent magnet and conventional electromagnets are used in this area. The LER lattice has now adopted a simplified non-interleaved sextupole correction scheme that has reduced the required number of sextupoles substantially. We describe the LER vacuum system, one of the most challenging subsystems in PEP-II. It employs several technologies. In the arcs, aluminum extrusions and titanium sublimation pumps are employed; the straight sections use stainless steel chambers with lumped ion pumps. In the wiggler area, an extended copper photon dump with nonevaporable getter (NEG) pumps is employed to handle the very large synchrotron radiation power. The design of the room-temperature RF system, the bunch-by-bunch longitudinal and transverse feedback systems, and some of the special diagnostics will be described briefly. The PEP-II project remains on schedule to begin commissioning of the HER in April 1997, followed by the LER a year later

  11. Cancer Cell Resistance to Aurora Kinase Inhibitors: Identification of Novel Targets for Cancer Therapy

    Czech Academy of Sciences Publication Activity Database

    Hrabáková, Rita; Kollaredy, M.; Tylečková, Jiřina; Halada, Petr; Hajdúch, M.; Gadher, S. J.; Kovářová, Hana

    2013-01-01

    Roč. 12, č. 1 (2013), s. 455-469 ISSN 1535-3893 R&D Projects: GA MŠk LC07017 Institutional support: RVO:67985904 ; RVO:61388971 Keywords : Aurora kinase inhibitors * resistance * p53 * apoptosis Subject RIV: CE - Biochemistry Impact factor: 5.001, year: 2013

  12. Aurora kinase A is essential for correct chromosome segregation in mouse zygote

    Czech Academy of Sciences Publication Activity Database

    Kovaříková, V.; Burkus, J.; Rehák, P.; Brzáková, Adéla; Šolc, Petr; Baran, V.

    2016-01-01

    Roč. 24, č. 3 (2016), s. 326-337 ISSN 0967-1994 R&D Projects: GA MŠk ED2.1.00/03.0124 Institutional support: RVO:67985904 Keywords : apoptosis * aurora A * MLN8237 * mouse zygote * spindle Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.053, year: 2016

  13. GATEWAY Demonstrations: OLED Lighting in the Offices of Aurora Lighting Design, Inc.

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Naomi J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-03-31

    At the offices of Aurora Lighting Design, Inc., in Grayslake, IL, the GATEWAY program conducted its first investigation involving OLED lighting. The project experienced several challenges, but also highlighted a number of promising attributes – which indicate that with continued improvements in efficacy, longevity, size, and flexibility, OLEDs could provide a new tool for creative and effective lighting.

  14. Dedicated OO expertise applied to Run II software projects

    International Nuclear Information System (INIS)

    Amidei, D.

    2000-01-01

    The change in software language and methodology by CDF and D0 to object-oriented from procedural Fortran is significant. Both experiments requested dedicated expertise that could be applied to software design, coding, advice and review. The Fermilab Run II offline computing outside review panel agreed strongly with the request and recommended that the Fermilab Computing Division hire dedicated OO expertise for the CDF/D0/Computing Division joint project effort. This was done and the two experts have been an invaluable addition to the CDF and D0 upgrade software projects and to the Computing Division in general. These experts have encouraged common approaches and increased the overall quality of the upgrade software. Advice on OO techniques and specific advice on C++ coding has been used. Recently a set of software reviews has been accomplished. This has been a very successful instance of a targeted application of computing expertise, and constitutes a very interesting study of how to move toward modern computing methodologies in HEP

  15. Blade System Design Study. Part II, final project report (GEC).

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, Dayton A. (DNV Global Energy Concepts Inc., Seattle, WA)

    2009-05-01

    As part of the U.S. Department of Energy's Low Wind Speed Turbine program, Global Energy Concepts LLC (GEC)1 has studied alternative composite materials for wind turbine blades in the multi-megawatt size range. This work in one of the Blade System Design Studies (BSDS) funded through Sandia National Laboratories. The BSDS program was conducted in two phases. In the Part I BSDS, GEC assessed candidate innovations in composite materials, manufacturing processes, and structural configurations. GEC also made recommendations for testing composite coupons, details, assemblies, and blade substructures to be carried out in the Part II study (BSDS-II). The BSDS-II contract period began in May 2003, and testing was initiated in June 2004. The current report summarizes the results from the BSDS-II test program. Composite materials evaluated include carbon fiber in both pre-impregnated and vacuum-assisted resin transfer molding (VARTM) forms. Initial thin-coupon static testing included a wide range of parameters, including variation in manufacturer, fiber tow size, fabric architecture, and resin type. A smaller set of these materials and process types was also evaluated in thin-coupon fatigue testing, and in ply-drop and ply-transition panels. The majority of materials used epoxy resin, with vinyl ester (VE) resin also used for selected cases. Late in the project, testing of unidirectional fiberglass was added to provide an updated baseline against which to evaluate the carbon material performance. Numerous unidirectional carbon fabrics were considered for evaluation with VARTM infusion. All but one fabric style considered suffered either from poor infusibility or waviness of fibers combined with poor compaction. The exception was a triaxial carbon-fiberglass fabric produced by SAERTEX. This fabric became the primary choice for infused articles throughout the test program. The generally positive results obtained in this program for the SAERTEX material have led to its

  16. Recent developments in pulsating aurora studies

    International Nuclear Information System (INIS)

    Sandahl, I.

    1985-11-01

    The field of pulsating aurora studies is reviewed. The paper begins with a short description of the characteristics of pulsating auroras and the theoretical ideas which, in view of existing experimental results, seem most important. A selection of new theoretical results and experimental results from both ground based instruments and instruments on rockets and satellites is then presented. There is now convincing evidence that the luminosity modulation is caused by a modulated flux of electron. The electron flux modulation seems to arise from a modulated resonant interaction between electrons and whistler mode waves in the equatorial plane, but the reason for the modulation is not known. Measurements concerning the drift and location of patches and the creation of Pi1 micropulsations are also deiscussed. Finally some suggestions for future research work are outlined. Optical measurements, especially with low light level TV, have proven to be of great importance in experimental studies of pulsating auroras. (author)

  17. The first accurate description of an aurora

    Science.gov (United States)

    Schröder, Wilfried

    2006-12-01

    As technology has advanced, the scientific study of auroral phenomena has increased by leaps and bounds. A look back at the earliest descriptions of aurorae offers an interesting look into how medieval scholars viewed the subjects that we study.Although there are earlier fragmentary references in the literature, the first accurate description of the aurora borealis appears to be that published by the German Catholic scholar Konrad von Megenberg (1309-1374) in his book Das Buch der Natur (The Book of Nature). The book was written between 1349 and 1350.

  18. 2-Aminobenzimidazoles as potent Aurora kinase inhibitors.

    Science.gov (United States)

    Zhong, Min; Bui, Minna; Shen, Wang; Baskaran, Subramanian; Allen, Darin A; Elling, Robert A; Flanagan, W Michael; Fung, Amy D; Hanan, Emily J; Harris, Shannon O; Heumann, Stacey A; Hoch, Ute; Ivy, Sheryl N; Jacobs, Jeffrey W; Lam, Stuart; Lee, Heman; McDowell, Robert S; Oslob, Johan D; Purkey, Hans E; Romanowski, Michael J; Silverman, Jeffrey A; Tangonan, Bradley T; Taverna, Pietro; Yang, Wenjin; Yoburn, Josh C; Yu, Chul H; Zimmerman, Kristin M; O'Brien, Tom; Lew, Willard

    2009-09-01

    This Letter describes the discovery and key structure-activity relationship (SAR) of a series of 2-aminobenzimidazoles as potent Aurora kinase inhibitors. 2-Aminobenzimidazole serves as a bioisostere of the biaryl urea residue of SNS-314 (1c), which is a potent Aurora kinase inhibitor and entered clinical testing in patients with solid tumors. Compared to SNS-314, this series of compounds offers better aqueous solubility while retaining comparable in vitro potency in biochemical and cell-based assays; in particular, 6m has also demonstrated a comparable mouse iv PK profile to SNS-314.

  19. Optical tomography of the aurora and EISCAT

    Directory of Open Access Journals (Sweden)

    H. U. Frey

    1998-10-01

    Full Text Available Tomographic reconstruction of the three-dimensional auroral arc emission is used to obtain vertical and horizontal distributions of the optical auroral emission. Under the given experimental conditions with a very limited angular range and a small number of observers, algebraic reconstruction methods generally yield better results than transform techniques. Different algebraic reconstruction methods are tested with an auroral arc model and the best results are obtained with an iterative least-square method adapted from emission-computed tomography. The observation geometry used during a campaign in Norway in 1995 is tested with the arc model and root-mean-square errors, to be expected under the given geometrical conditions, are calculated. Although optimum geometry was not used, root-mean-square errors of less than 2% for the images and of the order of 30% for the distribution could be obtained. The method is applied to images from real observations. The correspondence of original pictures and projections of the reconstructed volume is discussed, and emission profiles along magnetic field lines through the three-dimensionally reconstructed arc are calibrated into electron density profiles with additional EISCAT measurements. Including a background profile and the temporal changes of the electron density due to recombination, good agreement can be obtained between measured profiles and the time-sequence of calculated profiles. These profiles are used to estimate the conductivity distribution in the vicinity of the EISCAT site. While the radar can only probe the ionosphere along the radar beam, the three-dimensional tomography enables conductivity estimates in a large area around the radar site.Key words. Tomography · Aurora · EISCAT · Ionosphere · Conductivity

  20. Optical tomography of the aurora and EISCAT

    Directory of Open Access Journals (Sweden)

    H. U. Frey

    Full Text Available Tomographic reconstruction of the three-dimensional auroral arc emission is used to obtain vertical and horizontal distributions of the optical auroral emission. Under the given experimental conditions with a very limited angular range and a small number of observers, algebraic reconstruction methods generally yield better results than transform techniques. Different algebraic reconstruction methods are tested with an auroral arc model and the best results are obtained with an iterative least-square method adapted from emission-computed tomography. The observation geometry used during a campaign in Norway in 1995 is tested with the arc model and root-mean-square errors, to be expected under the given geometrical conditions, are calculated. Although optimum geometry was not used, root-mean-square errors of less than 2% for the images and of the order of 30% for the distribution could be obtained. The method is applied to images from real observations. The correspondence of original pictures and projections of the reconstructed volume is discussed, and emission profiles along magnetic field lines through the three-dimensionally reconstructed arc are calibrated into electron density profiles with additional EISCAT measurements. Including a background profile and the temporal changes of the electron density due to recombination, good agreement can be obtained between measured profiles and the time-sequence of calculated profiles. These profiles are used to estimate the conductivity distribution in the vicinity of the EISCAT site. While the radar can only probe the ionosphere along the radar beam, the three-dimensional tomography enables conductivity estimates in a large area around the radar site.

    Key words. Tomography · Aurora · EISCAT · Ionosphere · Conductivity

  1. Proyecto Aurora: Building a Community of Women.

    Science.gov (United States)

    Noya, Gladys R. Capella

    1997-01-01

    Describes the development of Proyecto Aurora, a program to develop and implement educational, support, and research programs to benefit low-income women in Puerto Rico. Portraits of some clients illustrate the rewards and challenges of working with this community and furthering their educational experiences and opportunities. (SLD)

  2. Functional design criteria for project W-252, phase II liquid effluent treatment and disposal. Revision 2

    International Nuclear Information System (INIS)

    Hatch, C.E.

    1995-05-01

    This document is the Functional Design Criteria for Project W-252. Project W-252 provides the scope to provide BAT/AKART (best available technology...) to 200 Liquid Effluent Phase II streams (B-Plant). This revision (Rev. 2) incorporates a major descoping of the project. The descoping was done to reflect a combination of budget cutting measures allowed by a less stringent regulatory posture toward the Phase II streams

  3. Observation of the pulsating aurora by S-520-12 rocket at Norway

    International Nuclear Information System (INIS)

    Tsuruda, K.; Hayakawa, H.; Machida, S.; Mukai, T.; Morioka, A.; Nagano, I.; Miyaoka, H.

    1991-01-01

    Particle, field an wave observations in a pulsating aurora have been carried out using the sounding rocket S-520-12, at northern polar region, Norway, on February 26, 1990. The initial analysis has disclosed two new findings, (i) precipitating low energy electrons associated with the auroral patch region, which suggests the secondary local acceleration of the auroral particles, (ii) pulsating LF wave component that is generated by periodically precipitating energetic electrons above the auroral ionosphere. (author)

  4. Horse-collar aurora: A frequent pattern of the aurora in quiet times

    International Nuclear Information System (INIS)

    Hones, E.W. Jr.; Craven, J.D.; Frank, L.A.; Evans, D.S.; Newell, P.T.

    1989-01-01

    Reported here are DE 1 auroral imager observations of an auroral configuration which is given the name ''horse-collar aurora.'' The horse-collar pattern comprises the total area of auroral emissions from a single hemisphere and derives its name from the shape of the emitting area. The pattern is found in images recorded during quiet geomagnetic conditions and is possibly related to the theta aurora, another quiet time configuration of the auroras. This initial report of the DE 1 observations illustrates the horse-collar aurora with a 2-hour images sequence that displays its basic features and shows an example of its evolution into a theta-like auroral pattern. The interplanetary magnetic field was northward during this image sequence and there is some evidence for IMF B/sub y/ influence of the temporal development of the horse-collar pattern. A preliminary statistical analysis found the horse-collar pattern appearing in one-third or more of image sequences recorded during quiet conditions; it did not appear during disturbed conditions. Further study is required to establish more fully the characteristics of the horse-collar aurora and to determine its implications concerning solar wind-magnetosphere coupling when the IMF B/sub z/ is northward. copyright American Geophysical Union 1989

  5. Jung's quest for the "Aurora consurgens"

    DEFF Research Database (Denmark)

    Haaning, Aksel

    2014-01-01

    Auriferae (1593); and it raises the question of whether this could be the possible missing link to Jung's subsequent research in Alchemy and Hermetic Philosophy in the years to come. It is argued that here was the beginning of Jung's quest for the Aurora consurgens, the publication of which concludes...... the Mysterium Conuinctionis more than twenty years later. It is further maintained that this choice of the Aurora is a profound expression of Jung's ambition to revitalize the past from within the individual, and helps explain Jung's deep concern with the welfare and future of modern society.......The paper focuses on the year 1929 when Jung published ‘A European commentary’ to Richard Wilhelm's German translation of the Taoist text The Secret of the Golden Flower. This shows that Jung had already started on the track of European alchemy by following up Conrad Waldkirch's preface in Artis...

  6. Aurorae. Firework in the sky. 2. upd. ed.

    International Nuclear Information System (INIS)

    Pfoser, Andreas; Eklund, Tom

    2013-01-01

    Aurorae are fascinating phenomena. As aurora borealis and aurora australis occurring in the polar regions of both earth hemispheres, their incessant color and shape games put people in wonder. The meteorologist Andreas Pfoser explains the physical connections, which lead to the formation of this natural phenomenon. The link with the activity of the sun and the interaction in the earth atmosphere are explained detailedly and understandably. The fantastic recordings, presented in generous horizontal format has collected the Finnish aurora photographer Tom Eklund over a period of time of 14 years. Thereby it succeeded, to document also some events, the origin of which on our daystar were recorded by solar satellites, so that the sequence of events from the solar eruption until the aurora spectacle can be reproduced. The present 2nd edition contains new scientific findings. Additionally numerous aurora pictures were replaced by more actual photos created with modern technology.

  7. Aurora A's functions during mitotic exit: the Guess Who game

    Directory of Open Access Journals (Sweden)

    David eReboutier

    2015-12-01

    Full Text Available Until recently, the knowledge of Aurora A kinase functions during mitosis was limited to pre-metaphase events, particularly centrosome maturation, G2/M transition, and mitotic spindle assembly. However, an involvement of Aurora A in post-metaphase events was also suspected, but not clearly demonstrated due to the technical difficulty to perform the appropriate experiments. Recent developments of both an analog specific version of Aurora A, and of small molecule inhibitors have led to the first demonstration that Aurora A is required for the early steps of cytokinesis. As in pre-metaphase, Aurora A plays diverse functions during anaphase, essentially participating in astral microtubules dynamics and central spindle assembly and functioning. The present review describes the experimental systems used to decipher new functions of Aurora A during late mitosis and situate these functions into the context of cytokinesis mechanisms.

  8. Aurora kinase inhibitors: Progress towards the clinic

    Czech Academy of Sciences Publication Activity Database

    Kollareddy, M.; Zheleva, D.; Dzubak, P.; Brahmkshatriya, Pathik; Lepšík, Martin; Hajduch, M.

    2012-01-01

    Roč. 30, č. 6 (2012), s. 2411-2432 ISSN 0167-6997 Grant - others:GA ČR(CZ) GA301/08/1649; GA ČR(CZ) GD303/09/H048 Program:GA; GD Institutional research plan: CEZ:AV0Z40550506 Keywords : Aurora kinases * cancer * inhibitors Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 3.498, year: 2012

  9. Electron energy measurements in pulsating auroras

    International Nuclear Information System (INIS)

    McEwan, D.J.; Yee, E.; Whalen, B.A.; Yau, A.W.

    1981-01-01

    Electron spectra were obtained during two rocket flights into pulsating aurora from Southend, Saskatchewan. The first rocket launched at 1143:24 UT on February 15, 1980 flew into an aurora of background intensity 275 R of N 2 + 4278 A and showing regular pulsations with about a 17 s period. Electron spectra of Maxwellian energy distributions were observed with an average E 0 = 1.5 keV, rising to 1.8 keV during the pulsations. There was one-to-one correspondence between the electron energy modulation and the observed optical pulsations. The second rocket, launched at 1009:10 UT on February 23, flew into a diffuse auroral surface of intensity 800 R of N 2 + 4278 A and with somewhat irregular pulsations. The electron spectra were again of Maxwellian energy distribution with an average E 0 = 1.8 keV increasing to 2.1 keV during the pulsations. The results from these flights suggest that pulsating auroras occurring in the morning sector may be quite commonly excited by low energy electrons. The optical pulsations are due to periodic increases in the energy of the electrons with the source of modulation in the vicintiy of the geomagnetic equatorial plane. (auth)

  10. Dayside aurorae and their relation to other geophysical phenomena

    International Nuclear Information System (INIS)

    Leontyev, S.V.; Starkov, G.V.; Vorobjev, V.G.; Zverev, V.L.; Feldstein, Ya.I.

    1992-01-01

    Principal morphological peculiarities of auroral luminosity are investigated on the basis of the data from multi-year aurorae observations in day hours at Spitzbergen and Franz Jozef Land. It is shown that in this region the typical forms of aurorae are moving poleward rayed arcs appearing at the equatorward boundary of the auroral oval and disappearing at its pole boundary. Discrete forms of aurorae are located inside a much broader red luminosity band in its equatorward part. Auroral pulsations with a period of 10 50 s are observed in the prenoon sector in a region of much harder precipitations found more equatorward with respect to the daytime red luminosity band. The influence of a B z IMF component upon daytime aurorae is exercised both directly through an equatorward (poleward) shift of daytime aurorae upon decreasing (increasing) B z and via an increase in planetary geomagnetic activity related to the appearance of substorms during which the whole region of the daytime luminosity is shifted to much lower latitudes. A decrease of intensity of daytime aurorae with duration of 5-10 min before the beginning of an expansive phase of a substorm on the night side is detected. The peculiarities of the daytime aurorae dynamics during substorms are also investigated. A scheme of the daytime auroral luminosity distribution is presented. Analytical expressions of the dependence of the daytime aurorae position on IMF are provided. Certain physical mechanisms that can explain the peculiarities of daytime aurorae dynamics are also discussed. (Author)

  11. FEBEX II Project Post-mortem analysis EDZ assessment

    International Nuclear Information System (INIS)

    Bazargan Sabet, B.; Shao, H.; Autio, J.; Elorza, F. J.

    2004-01-01

    Within the framework of the FEBEX II project a multidisciplinary team studied the mechanisms of creation of the potential damaged zone around the test drift. The research program includes laboratory and in situ investigations as well as the numerical modelling of the observed phenomena. Where laboratory investigations are concerned, the 14C-PMMA technique was applied to study the spatial distribution of porosity in the samples taken from the test drift wall. In addition complementary microscopy and scanning electron microscopy (SEM) studies were performed to make qualitative investigations on the pore apertures and minerals in porous regions. The results obtained with the PMMA method have not shown any clear increased porosity zone adjacent to the tunnel wall. The total porosity of the samples varied between 0.6-1.2%. The samples of unplugged region did not differ from the samples of plugged region. A clear increase in porosity to depths of 10-15 mm from the tunnel wall was detected in lamprophyre samples. According to the SEM/EDX analyses the excavation-disturbed zone in the granite matrix extended to depths of 1-3 mm from the wall surface. A few quartz grains were crushed and some micro fractures were found. Gas permeability tests were carried out on two hollow cylinder samples of about 1m long each taken on the granite wall perpendicular to the drift axis. The first sample was cored in the service area far from the heated zone and the second one at the level of the heater. The tests were performed at constant gas pressure by setting a steady state radial flow through a section of 1cm wide isolated by means of four mini-packers. The profile of the gas permeability according to the core length has been established. The results obtained for both considered samples have shown permeability ranging between 3.5 10-18 and 8.4 10-19m2, pointing out the absence of a marked damage. Acoustic investigations have been carried out with the objective of quantifying the

  12. FEBEX II Project Post-mortem analysis EDZ assessment

    Energy Technology Data Exchange (ETDEWEB)

    Bazargan Sabet, B.; Shao, H.; Autio, J.; Elorza, F. J.

    2004-07-01

    Within the framework of the FEBEX II project a multidisciplinary team studied the mechanisms of creation of the potential damaged zone around the test drift. The research program includes laboratory and in situ investigations as well as the numerical modelling of the observed phenomena. Where laboratory investigations are concerned, the 14C-PMMA technique was applied to study the spatial distribution of porosity in the samples taken from the test drift wall. In addition complementary microscopy and scanning electron microscopy (SEM) studies were performed to make qualitative investigations on the pore apertures and minerals in porous regions. The results obtained with the PMMA method have not shown any clear increased porosity zone adjacent to the tunnel wall. The total porosity of the samples varied between 0.6-1.2%. The samples of unplugged region did not differ from the samples of plugged region. A clear increase in porosity to depths of 10-15 mm from the tunnel wall was detected in lamprophyre samples. According to the SEM/EDX analyses the excavation-disturbed zone in the granite matrix extended to depths of 1-3 mm from the wall surface. A few quartz grains were crushed and some micro fractures were found. Gas permeability tests were carried out on two hollow cylinder samples of about 1m long each taken on the granite wall perpendicular to the drift axis. The first sample was cored in the service area far from the heated zone and the second one at the level of the heater. The tests were performed at constant gas pressure by setting a steady state radial flow through a section of 1cm wide isolated by means of four mini-packers. The profile of the gas permeability according to the core length has been established. The results obtained for both considered samples have shown permeability ranging between 3.5 10-18 and 8.4 10-19m2, pointing out the absence of a marked damage. Acoustic investigations have been carried out with the objective of quantifying the

  13. A Manhattan Project in Educational Technology, Part II.

    Science.gov (United States)

    Roberts, Wesley K.

    The initial four phases of the Training Extension Course (TEC), a project to remedy deficiencies in training programs for armed forces recruits, employed systematic instructional development and extensive audiovisual resources. The project required subcontracting for lesson production and modifications in personnel and budgeting. Posttest evidence…

  14. Swarm-Aurora: A web-based tool for quickly identifying multi-instrument auroral events

    Science.gov (United States)

    Chaddock, D.; Donovan, E.; Spanswick, E.; Knudsen, D. J.; Frey, H. U.; Kauristie, K.; Partamies, N.; Jackel, B. J.; Gillies, M.; Holmdahl Olsen, P. E.

    2016-12-01

    In recent years there has been a dramatic increase in ground-based auroral imaging systems. These include the continent-wide THEMIS-ASI network, and imagers operated by other programs including GO-Canada, MIRACLE, AGO, OMTI, and more. In the near future, a new Canadian program called TREx will see the deployment of new narrow-band ASIs that will provide multi-wavelength imaging across Western Canada. At the same time, there is an unprecedented fleet of international spacecraft probing geospace at low and high altitudes. We are now in the position to simultaneously observe the magnetospheric drivers of aurora, observe in situ the waves, currents, and particles associated with MI coupling, and the conjugate aurora. Whereas a decade ago, a single magnetic conjunction between one ASI and a low altitude satellite was a relatively rare event, we now have a plethora of triple conjunctions between imagers, low-altitude spacecraft, and near-equatorial magnetospheric probes. But with these riches comes a new level of complexity. It is often difficult to identify the many useful conjunctions for a specific line of inquiry from the multitude of conjunctions where the geospace conditions are often not relevant and/or the imaging is compromised by clouds, moon, or other factors. Swarm-Aurora was designed to facilitate and drive the use of Swarm in situ measurements in auroral science. The project seeks to build a bridge between the Swarm science community, Swarm data, and the complimentary auroral data and community. Swarm-Aurora (http://swarm-aurora.phys.ucalgary.ca) incorporates a web-based tool which provides access to quick-look summary data for a large array of instruments, with Swarm in situ and ground-based ASI data as the primary focus. This web interface allows researchers to quickly and efficiently browse Swarm and ASI data to identify auroral events of interest to them. This allows researchers to be able to easily and quickly identify Swarm overflights of ASIs that

  15. Wind River Watershed Project; 1998 Annual Report; Volume II

    International Nuclear Information System (INIS)

    Connolly, Patrick J.

    1999-01-01

    The authors report here their on-ground restoration actions. Part 1 describes work conducted by the Underwood Conservation District (UCD) on private lands. This work involves the Stabler Cut-Bank project. Part 2 describes work conducted by the U.S. Forest Service. The Stabler Cut-Bank Project is a cooperative stream restoration effort between Bonneville Power Administration (BPA), the UCD, private landowners, the U.S. Forest Service (USFS), and the U.S. Fish and Wildlife Service (USFWS). The Stabler site was identified by UCD during stream surveys conducted in 1996 as part of a USFWS funded project aimed at initiating water quality and habitat restoration efforts on private lands in the basin. In 1997 the Wind River Watershed Council selected the project as a top priority demonstration project. The landowners were approached by the UCD and a partnership developed. Due to their expertise in channel rehabilitation, the Forest Service was consulted for the design and assisted with the implementation of the project. A portion of the initial phase of the project was funded by USFWS. However, the majority of funding (approximately 80%) has been provided by BPA and it is anticipated that additional work that is planned for the site will be conducted with BPA funds

  16. 139 the impact of the national fadama ii development project

    African Journals Online (AJOL)

    OLUWOLE AKINNAGBE

    Key words: Impact, National Fadama II Facility, Poverty Alleviation, Agricultural ... production but enhance the income of the ... of employment has the higher incidence of ... This widening gap between ... each group (i.e. those earning ... Source: Field Survey data, 2007 .... increased as evidence has shown that the level.

  17. Bora and Aurora-A continue to activate Plk1 in mitosis

    Czech Academy of Sciences Publication Activity Database

    Bruinsma, W.; Macůrek, Libor; Freire, R.; Lindqvist, A.; Medema, R.H.

    2014-01-01

    Roč. 127, č. 4 (2014), s. 801-811 ISSN 0021-9533 R&D Projects: GA ČR GA13-18392S Grant - others:Ministerio de Economía y Competitividad(ES) SAF2010-22357; CONSOLIDER-Ingenio(NL) CDS2007-0015 Keywords : Aurora-A * Bora * Mitosis * Plk1 Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 5.432, year: 2014

  18. GATEWAY Report Brief: OLED Lighting in the Offices of Aurora Lighting Design, Inc.

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2016-05-31

    Summary of a GATEWAY report evaluation at the offices of Aurora Lighting Design, Inc., in Grayslake, IL, where the GATEWAY program conducted its first investigation involving OLED lighting. The project experienced several challenges, but also highlighted a number of promising attributes – which indicate that with continued improvements in efficacy, longevity, size, and flexibility, OLEDs could provide a new tool for creative and effective lighting.

  19. Final report on the maintenance asset management project : phase II.

    Science.gov (United States)

    2013-07-01

    Iowa Department of Transportation (IA DOT) is finalizing research to streamline field inventory/inspection of culverts by Maintenance and Construction staff while maximizing the use of tablet technologies. The project began in 2011 to develop some ne...

  20. S-1 project. Volume II. Hardware. 1979 annual report

    Energy Technology Data Exchange (ETDEWEB)

    1979-01-01

    This volume includes highlights of the design of the Mark IIA uniprocessor (SMI-2), and the SCALD II user's manual. SCALD (structured computer-aided logic design system) cuts the cost and time required to design logic by letting the logic designer express ideas as naturally as possible, and by eliminating as many errors as possible - through consistency checking, simulation, and timing verification - before the hardware is built. (GHT)

  1. Accelerator Physics Challenges for the NSLS-II Project

    Energy Technology Data Exchange (ETDEWEB)

    Krinsky,S.

    2009-05-04

    The NSLS-II is an ultra-bright synchrotron light source based upon a 3-GeV storage ring with a 30-cell (15 super-period) double-bend-achromat lattice with damping wigglers used to lower the emittance below 1 nm. In this paper, we discuss the accelerator physics challenges for the design including: optimization of dynamic aperture; estimation of Touschek lifetime; achievement of required orbit stability; and analysis of ring impedance and collective effects.

  2. The EMIL project at BESSY II: Beamline design and performance

    Energy Technology Data Exchange (ETDEWEB)

    Hendel, Stefan, E-mail: stefan.hendel@helmholtz-berlin.de; Schäfers, Franz; Reichardt, Gerd; Scheer, Michael; Bahrdt, Johannes; Lips, Klaus [Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Albert-Einstein-Straße 15, 12489 Berlin (Germany); Hävecker, Michael [Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Albert-Einstein-Straße 15, 12489 Berlin (Germany); MPI for Chemical Energy Conversion, Stiftstrasse 34-36, 45470 Mülheim an der Ruhr (Germany)

    2016-07-27

    The Energy Materials In-Situ Laboratory Berlin (EMIL) at BESSY-II is currently under construction. Two canted undulators for soft- and hard X-rays will be installed into the BESSY II storage ring in one straight section, complex beamlines with more than twenty optical elements will be set up and a new laboratory building attached to BESSY II will host three endstations and a large UHV-transfer system connecting various HV- and UHV-deposition systems. The undulators, UE48 and U17, provide a broad energy spectrum of 80 - 10000 eV, of which the harder radiation (>700 eV) is provided by a cryogenic in-vacuum device. Three monochromators (two plane grating monochromators (PGM) and one LN{sub 2}-cooled double crystal monochromator (DCM)) disperse the radiation into separate pathways of 65 m length, while downstream of the monochromators split-mirror chambers distribute the photon beam to one (or simultaneously to two) of five upcoming endstations. Three of these endstations are designed for the full energy range with spatial overlap of the soft and hard foci, whereas one endstation (PEEM) uses only the soft and another one (PINK) only the hard branch, respectively.

  3. Haspin kinase regulates microtubule-organizing center clustering and stability through Aurora kinase C in mouse oocytes

    Czech Academy of Sciences Publication Activity Database

    Balboula, A. Z.; Nguyen, A. L.; Gentilello, A. S.; Quartuccio, S. M.; Drutovič, Dávid; Šolc, Petr; Schindler, K.

    2016-01-01

    Roč. 129, č. 19 (2016), s. 3648-3660 ISSN 0021-9533 R&D Projects: GA MŠk(CZ) LO1609 Institutional support: RVO:67985904 Keywords : haspin * aurora kinase * spindle * MTOC * oocyte Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.431, year: 2016

  4. [To live well: health care or life project? Part II].

    Science.gov (United States)

    Viniegra Velázquez, Leonardo

    On the basis that life project as the driving force behind the life experience, the quest for human dignity is the way for true progress and the improvement of human condition. It's pointed out the need to be aware of the meaning of life understanding the motives behind our will to live that is the antecedent of life project. The proposed life project is a cognitive adventure, capable of transcending consumerism, individualism and passivity, toward the creation of a more inclusive world where the improvement spiritual, intellectual and moral can be viable. Said life project entails: a) A primary need: to link oneself with like-minded people that synergize against the prevailing order b) A core: The everlasting struggle for sublimated dignity c) A desideratum: The well-being of the majority d) An unavoidable purpose: The creation of a suitable world build on different ethical, political, lawful, cognitive and ecological foundations. In conclusion, this paper analyzes the influence of projects with an alternate proposal to the endeavors centered in healthcare that favor individualism, passivity and the current status quo. The best example of said alternate proposals is the commonly called "good death". Copyright © 2016 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

  5. Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma

    NARCIS (Netherlands)

    Tavanti, E.; Sero, V.; Vella, S.; Fanelli, M.; Michelacci, F.; Landuzzi, L.; Magagnoli, G.; Versteeg, R.; Picci, P.; Hattinger, C. M.; Serra, M.

    2013-01-01

    Aurora kinases are key regulators of cell cycle and represent new promising therapeutic targets in several human tumours. Biological relevance of Aurora kinase-A and -B was assessed on osteosarcoma clinical samples and by silencing these genes with specific siRNA in three human osteosarcoma cell

  6. Genetic diversity in two populations of Limicolaria aurora (Jay, 1839 ...

    African Journals Online (AJOL)

    Limicolaria aurora belongs to the group of land snails commonly called garden snails. This study seeks to use shell morphology and random amplified polymorphic DNA-polymerase chain reaction (RAPDPCR) to examine gross morphological differences in populations of L. aurora from New Bussa (guinea savannah) and ...

  7. Source of the dayside cusp aurora.

    Science.gov (United States)

    Mende, S B; Frey, H U; Angelopoulos, V

    2016-08-01

    Monochromatic all-sky imagers at South Pole and other Antarctic stations of the Automatic Geophysical Observatory chain recorded the aurora in the region where the Time History of Events and Macroscale Interactions during Substorms (THEMIS) satellites crossed the dayside magnetopause. In several cases the magnetic field lines threading the satellites when mapped to the atmosphere were inside the imagers' field of view. From the THEMIS magnetic field and the plasma density measurements, we were able to locate the position of the magnetopause crossings and map it to the ionosphere using the Tsyganenko-96 field model. Field line mapping is reasonably accurate on the dayside subsolar region where the field is strong, almost dipolar even though compressed. From these coordinated observations, we were able to prove that the dayside cusp aurora of high 630 nm brightness is on open field lines, and it is therefore direct precipitation from the magnetosheath. The cusp aurora contained significant highly structured N 2 + 427.8 nm emission. The THEMIS measurements of the magnetosheath particle energy and density taken just outside the magnetopause compared to the intensity of the structured N 2 + 427.8 nm emissions showed that the precipitating magnetosheath particles had to be accelerated. The most likely electron acceleration mechanism is by dispersive Alfvén waves propagating along the field line. Wave-accelerated suprathermal electrons were seen by FAST and DMSP. The 427.8 nm wavelength channel also shows the presence of a lower latitude hard-electron precipitation zone originating inside the magnetosphere.

  8. SmartPark Technology Demonstration Project, Phase II: Final Report

    Science.gov (United States)

    2018-05-01

    The purpose of FMCSA's SmartPark project was to determine the feasibility of a technology for providing truck parking space availability information in real time to truckers on the road. SmartPark consisted of two phases. Phase I was a field operatio...

  9. Final Technical Report - Kotzebue Wind Power Project - Volume II

    Energy Technology Data Exchange (ETDEWEB)

    Rana Zucchi, Global Energy Concepts, LLC; Brad Reeve, Kotzebue Electric Association; DOE Project Officer - Doug Hooker

    2007-10-31

    The Kotzebue Wind Power Project is a joint undertaking of the U.S. Department of Energy (DOE); Kotzebue Electric Association (KEA); and the Alaska Energy Authority (AEA). The goal of the project is to develop, construct, and operate a wind power plant interconnected to a small isolated utility grid in an arctic climate in Northwest Alaska. The primary objective of KEA’s wind energy program is to bring more affordable electricity and jobs to remote Alaskan communities. DOE funding has allowed KEA to develop a multi-faceted approach to meet these objectives that includes wind project planning and development, technology transfer, and community outreach. The first wind turbines were installed in the summer of 1997 and the newest turbines were installed in the spring of 2007. The total installed capacity of the KEA wind power project is 1.16 MW with a total of 17 turbines rated between 65 kW and 100 kW. The operation of the wind power plant has resulted in a wind penetration on the utility system in excess of 35% during periods of low loads. This document and referenced attachments are presented as the final technical report for the U.S. Department of Energy (DOE) grant agreement DE-FG36-97GO10199. Interim deliverables previously submitted are also referenced within this document and where reasonable to do so, specific sections are incorporated in the report or attached as appendices.

  10. SEL/Project Language. Level II, Kindergarten, Teacher's Handbook.

    Science.gov (United States)

    Valladares, Ann E.; Lynch, Helen C.

    The Teacher's Handbook is part of the publication series of the Southeastern Education Laboratory/Project Language (SEL/PL), an 8-year language-centered program designed to alleviate the language deficiencies of disadvantaged children between the ages of four and eleven. For teachers utilizing SEL/PL, the Handbook provides a research summary and…

  11. Projective limits of state spaces II. Quantum formalism

    Science.gov (United States)

    Lanéry, Suzanne; Thiemann, Thomas

    2017-06-01

    In this series of papers, we investigate the projective framework initiated by Kijowski (1977) and Okołów (2009, 2014, 2013), which describes the states of a quantum theory as projective families of density matrices. A short reading guide to the series can be found in Lanéry (2016). After discussing the formalism at the classical level in a first paper (Lanéry, 2017), the present second paper is devoted to the quantum theory. In particular, we inspect in detail how such quantum projective state spaces relate to inductive limit Hilbert spaces and to infinite tensor product constructions (Lanéry, 2016, subsection 3.1) [1]. Regarding the quantization of classical projective structures into quantum ones, we extend the results by Okołów (2013), that were set up in the context of linear configuration spaces, to configuration spaces given by simply-connected Lie groups, and to holomorphic quantization of complex phase spaces (Lanéry, 2016, subsection 2.2) [1].

  12. Savanna ecosystem project: phase I summary and phase II progress

    CSIR Research Space (South Africa)

    Huntely, BJ

    1978-07-01

    Full Text Available A summary of the results of the first phase (mid 1974 to mid 1976) of the South African Savanna Ecosystem Project being undertaken at Nylsvley in the northern Transvaal is presented. Phase I of this ten year study of the structure and functioning...

  13. EBR-II spent fuel treatment demonstration project

    International Nuclear Information System (INIS)

    Benedict, R.W.; Henslee, S.P.

    1997-01-01

    For approximately 10 years, Argonne National Laboratory was developed a fast reactor fuel cycle based on dry processing. When the US fast reactor program was canceled in 1994, the fuel processing technology, called the electrometallurgical technique, was adapted for treating unstable spent nuclear fuel for disposal. While this technique, which involves electrorefining fuel in a molten salt bath, is being developed for several different fuel categories, its initial application is for sodium-bonded metallic spent fuel. In June 1996, the Department of Energy (DOE) approved a radiation demonstration program in which 100 spent driver assemblies and 25 spent blanket assemblies from the Experimental Breeder Reactor-II (EBR-II) will be treated over a three-year period. This demonstrated will provide data that address issues in the National Research Council's evaluation of the technology. The planned operations will neutralize the reactive component (elemental sodium) in the fuel and produce a low enriched uranium product, a ceramic waste and a metal waste. The fission products and transuranium elements, which accumulate in the electrorefining salt, will be stabilized in the glass-bonded ceramic waste form. The stainless steel cladding hulls, noble metal fission products, and insoluble residues from the process will be stabilized in a stainless steel/zirconium alloy. Upon completion of a successful demonstration and additional environmental evaluation, the current plans are to process the remainder of the DOE sodium bonded fuel

  14. Quantitative imaging studies with PET VI. Project II

    International Nuclear Information System (INIS)

    Copper, M.; Chen, C.T.; Yasillo, N.; Gatley, J.; Ortega, C.; DeJesus, O.; Friedman, A.

    1985-01-01

    This project is focused upon the development of hardware and software to improve PET image analysis and upon clinical applications of PET. In this report the laboratory's progress in various attenuation correction methods for brain imaging are described. The use of time-of-flight information for image reconstruction is evaluated. The location of dopamine D1 and D2 receptors in brain was found to be largely in the basal ganghia. 1 tab. (DT)

  15. Carbon dioxide, temperature, salinity, and other variables collected via surface underway survey from Volunteer Observing Ship AURORA AUSTRALIS in the Southern Oceans (> 60 degrees South) from 1992-10-19 to 2001-12-12 (NODC Accession 0081031)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Surface and Atmospheric fCO2 measurements in the Southern Ocean during the VOS Project line onboard the oceanographic ship Aurora Australis.

  16. Source region of aurora kilometric radiation

    International Nuclear Information System (INIS)

    Morioka, Akira; Oya, Hiroshi; Tokumaru, Munetoshi

    1981-01-01

    This paper discusses the source region of aurora kilometric radiation (AKR), and the relation between the particle acceleration region and the polar ionosphere. The observation was made by the satellite 'Jikiken'. The AKR can be transferred to Jikiken without any interception, when the magnetic latitude of the apogee of the satellite is low. The spectra taken in June, 1980, were analyzed. The observed spectra showed the source regions of the AKR were in the aurora bands of the north and south poles. One example showed that the 200 kHz component of AKR from both poles showed the similar behavior, and another example showed that the AKR spectra from both poles showed different behavior. The altitude distribution of source regions was able to be obtained. The altitude of AKR-A was in the range between 6200 and 12000 km, and that of AKR-B was in the range of 3500 and 5200 km. The source of AKR-A was identified as that in the south hemisphere, and that of AKR-B in the north hemisphere. The asymmetric spectra of AKR-A and B showed that the spread and intensity of the electric field along magnetic lines generated above the polar ionosphere were related with the conditions of the ionosphere. (Kato, T.)

  17. Draft Environmental Impact Statement: Proposed Tenaska, Washington II Generation Project

    International Nuclear Information System (INIS)

    1993-08-01

    BPA is considering whether to purchase electrical power from a proposed privately-owned combustion-turbine electrical generation plant in Washington. The plant would be fired by natural gas and would use combined-cycle technology to generate 240 average megawatts (aMW) of energy. The plant would be developed, owned, and operated by Tenaska Power Partners, Inc. The project would be located about 19 kilometers (12 miles) southeast of downtown Tacoma in the Frederickson Industrial Area, Pierce County. The proposed plant would occupy about half of a 6.4-hectare (16-acre) parcel and would be consistent with the industrial character of its surroundings. The proposed site is currently undeveloped and zoned for industrial use by the county. Main environmental concerns identified in the scoping process and evaluated in the Environmental Impact Statement (EIS) include: potential air quality impacts such as emissions and their contribution to the ''greenhouse'' effect; potential health and safety impacts, such as nuisance odors, plant safety, visibility and heat-emission systems which may affect low-flying planes and potential health effects of electric and magnetic fields, and potential water quality impacts such as the amount of wastewater to be discharged, the source and amount of water required for plant operation. These and other issues are discussed in detail in the EIS. The proposed project already includes many features designed to reduce environmental impacts. Based on investigations performed for the EIS, no significant unavoidable adverse environmental impacts associated with the proposed project were identified, and no evidence emerged to suggest that the proposed action is particularly controversial. The EIS is being mailed to numerous agencies, groups, and individuals. There will be a 45-day comment period, during which a Public Hearing will be held

  18. Project NOAH: Regulating modern sea-level rise. Phase II: Jerusalem Underground

    Science.gov (United States)

    Newman, Walter S.; Fairbridge, Rhodes W.

    This proposal builds a high-speed inter-urban express between Jerusalem and Tel Aviv, generates 1500 megawatts of hydroelectric energy, curtails littoral erosion, builds a port along the Israeli Mediterranean coast and demands peaceful cooperation on both sides of the Jordan River. Phase II represents a pilot project demonstrating the feasibility of continuing to regulate world sea-level by a new series of water regulation schemes. Phase I previously described all those projects already completed or underway which have inadvertently and/or unintentionally served the purpose of sea-level regulation. These forms of Phase I sea-level regulation include large and small reservoirs, irrigation projects, water infiltration schemes, farm ponds, and swimming and reflecting pools. All these water storage projects have already exercised a very appreciable brake on 20th century sea-level rise. Phase II outlines a high-visibility proposal which will serve to illustrate the viability of “Project NOAH”.

  19. THE RELATIONSHIP BETWEEN THE SEPTEMBER 2017 MARS GLOBAL AURORA EVENT AND CRUSTAL MAGNETIC FIELDS

    Science.gov (United States)

    Nasr, Camella-Rosa; Schneider, Nick; Connour, Kyle; Jain, Sonal; Deighan, Justin; Jakosky, Bruce; MAVEN/IUVS Team

    2018-01-01

    In September 2017, the Imaging UltraViolet Spectrograph (IUVS) on the MAVEN spacecraft observed global aurora on Mars caused by a surprisingly strong solar energetic particle event. Widespread “diffuse aurora” have previously been detected on Mars through more limited observations (Schneider et al., Science 350, (2015); DOI: 10.1126/science.aad0313), but recent observations established complete coverage of the observable portion of Mars’ nightside. The aurora was global due to Mars’s lack of a global magnetic field, which allowed energetic electrons from the Sun to directly precipitate into the atmosphere. On September 11th, IUVS detected aurora more than 25 times brighter than any prior IUVS observation, with high SNR detections of aurora at the limb and against the disk of the planet. Fainter auroral emission was seen around the nightside limb over 13 orbits spanning nearly 3 days.On September 14th, during the declining phase of the event, faint linear features and patches were detected by the spacecraft, which were higher than the noise floor, with a similar spatial distribution to “discrete aurora” patches observed on Mars by the SPICAM instrument on the Mars Express spacecraft (Bertaux et al., Nature 435, doi :10.1038/nature03603). Discrete aurora occur near areas of the crust affected by the magnetism left over from Mars’ once-strong dipole field. Emission is limited to regions of the crustal magnetic field where the field lines are likely to be open to solar wind interactions. Those regions are concentrated in Mars’ southern hemisphere centered on 180 degrees east longitude.We studied the localized emissions on 14 September to determine whether there might be a connection between the observed diffuse aurora event and discrete auroral processes. First, we investigated the localized emissions to confirm that the observed signal was consistent with expected auroral spectra. Second, their locations were projected on a map of the crustal magnetic

  20. Development and Performance of the 10 kN Hybrid Rocket Motor for the Stratos II Sounding Rocket

    NARCIS (Netherlands)

    Werner, R.M.; Knop, T.R.; Wink, J; Ehlen, J; Huijsman, R; Powell, S; Florea, R.; Wieling, W; Cervone, A.; Zandbergen, B.T.C.

    2016-01-01

    This paper presents the development work of the 10 kN hybrid rocket motor DHX-200 Aurora. The DHX-200 Aurora was developed by Delft Aerospace Rocket Engineering (DARE) to power the Stratos II and Stratos II+ sounding rocket, with the later one being launched in October 2015. Stratos II and Stratos

  1. Studsvik SUPER-RAMP-II: 9x9 Project

    International Nuclear Information System (INIS)

    Djurle, S.

    1991-12-01

    EPRI participated in an international program involving ramp-testing of 9 x 9 fuel rod segments in a test reactor in Sweden. The principal objective was to establish the pellet-cladding interaction (PCI) failure threshold for this type of fuel. Several segmented fuel rods were irradiated in Dresden-2 BWR with time-averaged linear heat ratings ranging from 13 to 17 kW/m up to average burnup ranging from 26 to 34 MWd/kgU. The segments were subsequently subjected to ramp-testing in the R2 reactor at Studsvik Nuclear. The ramp-testing consisted of an initial irradiation of peak linear heat rating between 12 to 16 kW/m for about two hours, followed by a rapid increase to a power level in the range of 36 to 50 kW/m. The upper power level was maintained for twelve hours or until the fuel failure was detected. The study concluded that for 9 x 9 fuel type the PCI failure threshold is ∼38 kW/m, independent of the burnup in the range of 26 to 34 MWd/kgU. This failure threshold is about 5 kW/m greater than that of traditional 8 x 8 design. Although the significance of this difference can be argued, the interim and final fuel examinations performed in this project by destructive and nondestructive methods revealed valuable detailed information on fuel performance, which is also documented and discussed in this report

  2. Staunton 1 Reclamation Demonstration Project. Progress report II

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-07-01

    The Staunton 1 Reclamation Demonstration Project involves an evaluation of the reclamation process on a 13.8-ha abandoned deep coal mine refuse site in southwestern Illinois. The procedure included collection of preconstruction environmental data, determination of the site's final land use, and development and implementation of a detailed site development plan. Approximately 9.3 ha of refuse material was recontoured, covered with a minimum of 30 cm of soil obtained on site, and seeded with a mixture of grasses and legumes. Hydrologic investigation indicates some improvement in groundwater quality. Surface water quality also has shown improvement, but development of the aquatic ecosystem in the newly-constructed pond is slow. Revegetation has been successful, and a protective plant cover has been established on most areas of the site. Soil tests indicate that acceptable plant growth media have been constructed; however, continued application of fertilizer and limestone will probably be necessary to maintain the vegetation. The soil microbial community has achieved total numbers equal to those of old fields, but species' diversity is low. Small mammals, birds, reptiles, and amphibians have invaded and are utilizing the site. The economic value of the site and adjacent property has increased substantially, and the area's aesthetic value has been enhanced significantly. The two-year period of intensive monitoring and evaluation has been utilized to develop recommendations for improving the designs of future reclamation efforts.

  3. Storm-time Convection Dynamics Viewed from Optical Auroras: from Streamer to Patchy Pulsating Aurora

    Science.gov (United States)

    Yang, B.; Donovan, E.; Liang, J.; Grono, E.

    2016-12-01

    In a series of statistical and event studies we have demonstrated that the motion of patches in regions of Patchy Pulsating Aurora (PPA) is very close to if not exactly convection. Thus, 2D maps of PPA motion provides us the opportunity to remote sense magnetospheric convection with relatively high space and time resolution, subject to uncertainties associated with mapping between the ionosphere and magnetosphere. In this study, we use THEMIS ASI aurora observations (streamers and patchy pulsating aurora) combined with SuperDARN convection measurements, Swarm ion drift velocity measurements, and RBSP electric field measurements to explore the convection dynamics in storm time. From 0500 UT to 0600 UT on March 19 2015, convection observations across 5 magnetic local time (MLT) inferred from the motion of PPA patches and SuperDARN measurements show that a westward SAPS (Subauroral Polarized Streams) enhancement occurs after an auroral streamer. This suggests that plasma sheet fast flows can affect the inner magnetospheric convection, and possibly trigger very fast flows in the inner magnetosphere.

  4. SEL/Project Language. Level II, Kindergarten, Volume II (Lessons 17-32).

    Science.gov (United States)

    Valladares, Ann E.; And Others

    This curriculum guide contains the Southeastern Education Laboratory/Project Language Lessons 17-32 stressing listening, speaking, and reading readiness for disadvantaged kindergarten children. The lessons are designed to be used in the SEL's mobile preschool units or as readiness materials for kindergarten. The major emphasis of this intervention…

  5. Title IV Quality Control Project, Stage II. Management Option II: Delivery System Quality Improvements.

    Science.gov (United States)

    Advanced Technology, Inc., Reston, VA.

    Stage Two of the Title IV Quality Control Project is an integrated study of quality in five related Federal financial aid programs for postsecondary students. Section 1 of the paper establishes a framework for defining quality improvements, in order to identify the types of changes that would tend to improve quality across all facets of the…

  6. Global magnetic anomaly and aurora of Neptune

    International Nuclear Information System (INIS)

    Cheng, A.F.

    1990-01-01

    The large offset and tilt of Neptune's dipole magnetic field combine to create a global magnetic anomaly, analogous to but much more important than Earth's South Atlantic Anomaly. Energetic particle precipitation loss within the Neptune anomaly creates atmospheric drift shadows within which particle fluxes are greatly reduced. The energetic particle dropout observed by Voyager near closest approach occurred near the predicted times when Voyager passed within the atmospheric drift shadow. Extremely soft, structured bursts of ions and electrons within the drift shadow may result from plasma wave-induced pitch angle scattering of trapped particles confined near the magnetic equator. The dropout does not necessarily imply that Voyager passed through an Earth-like discrete auroral zone, as earlier reported. The ion and electron fluxes observed within the dropout period correspond to particles that must precipitate to Neptune's atmosphere within the anomaly region. This anomaly precipitation can account for a major portion of the ultraviolet emissions previously identified as Neptune aurora

  7. The Aurora accelerator's triggered oil switch

    International Nuclear Information System (INIS)

    Weidenheimer, D.M.; Pereira, N.R.; Judy, D.C.; Stricklett, K.L.

    1993-01-01

    Achieving a radiation pulse with 15 ns risetime using all four of the Aurora accelerator's Blumlein pulse-forming lines demands synchronization of the Blumleins to within 10 ns (in addition to a 15 ns risetime for a single line). Timing of each Blumlein is controlled by a triggered 12 MV oil switch. A smaller-than-customary trigger electrode makes the switching time more reproducible. Time-resolved photography of the oil arcs suggests that triggering occurs simultaneously around the sharp edge of the trigger electrode, perhaps with small deviations that grow into the most prominent arcs characteristically seen in open-shutter photographs. However, many smaller arcs that are usually overlooked in open-shutter pictures may contribute to current conduction in a closed switch

  8. A Panchromatic View of Brown Dwarf Aurorae

    Energy Technology Data Exchange (ETDEWEB)

    Pineda, J. Sebastian [University of Colorado Boulder, Laboratory for Atmospheric and Space Physics, 3665 Discovery Drive, Boulder CO, 80303 (United States); Hallinan, Gregg; Kao, Melodie M. [California Institute of Technology, Department of Astronomy, 1200 E. California Avenue, Pasadena CA, 91125 (United States)

    2017-09-01

    Stellar coronal activity has been shown to persist into the low-mass star regime, down to late M-dwarf spectral types. However, there is now an accumulation of evidence suggesting that at the end of the main sequence, there is a transition in the nature of the magnetic activity from chromospheric and coronal to planet-like and auroral, from local impulsive heating via flares and MHD wave dissipation to energy dissipation from strong large-scale magnetospheric current systems. We examine this transition and the prevalence of auroral activity in brown dwarfs through a compilation of multiwavelength surveys of magnetic activity, including radio, X-ray, and optical. We compile the results of those surveys and place their conclusions in the context of auroral emission as a consequence of large-scale magnetospheric current systems that accelerate energetic electron beams and drive the particles to impact the cool atmospheric gas. We explore the different manifestations of auroral phenomena, like H α , in brown dwarf atmospheres and define their distinguishing characteristics. We conclude that large-amplitude photometric variability in the near-infrared is most likely a consequence of clouds in brown dwarf atmospheres, but that auroral activity may be responsible for long-lived stable surface features. We report a connection between auroral H α emission and quiescent radio emission in electron cyclotron maser instability pulsing brown dwarfs, suggesting a potential underlying physical connection between quiescent and auroral emissions. We also discuss the electrodynamic engines powering brown dwarf aurorae and the possible role of satellites around these systems both to power the aurorae and seed the magnetosphere with plasma.

  9. D4SCIENCE-II - Report on inter-projects coordination and collaboration

    OpenAIRE

    Castelli, Donatella; Zoppi, Franco

    2010-01-01

    This deliverable reports on the collaborations with other FP7 projects and R&D programmes established by D4Science-II from the beginning of the project until July 2010. The collaborations described are of different nature, as they range from purely technical exchanges involving mutual exploitation of technologies to the sharing of e- Infrastructure resources and to the joint organization of networking and dissemination events. The deliverable presents these collaborations clustered into: (i) ...

  10. FALSIRE Phase II. CSNI project for Fracture Analyses of Large-Scale International Reference Experiments (Phase II). Comparison report

    International Nuclear Information System (INIS)

    Sievers, J.; Schulz, H.; Bass, R.; Pugh, C.; Keeney, J.

    1996-11-01

    A summary of Phase II of the Project for Fracture Analysis of Large-Scale International Reference Experiments (FALSIRE) is presented. A FALSIRE II Workshop focused on analyses of reference fracture experiments. More than 30 participants representing 22 organizations from 12 countries took part in the workshop. Final results for 45 analyses of the reference experiments were received from the participating analysts. For each experiment, analysis results provided estimates of variables that include temperature, crack-mouth-opening displacement, stress, strain, and applied K and J values. The data were sent electronically to the Organizing Committee, who assembled the results into a comparative data base using a special-purpose computer program. A comparative assessment and discussion of the analysis results are presented in the report. Generally, structural responses of the test specimens were predicted with tolerable scatter bands. (orig./DG)

  11. Prioritizing sewer rehabilitation projects using AHP-PROMETHEE II ranking method.

    Science.gov (United States)

    Kessili, Abdelhak; Benmamar, Saadia

    2016-01-01

    The aim of this paper is to develop a methodology for the prioritization of sewer rehabilitation projects for Algiers (Algeria) sewer networks to support the National Sanitation Office in its challenge to make decisions on prioritization of sewer rehabilitation projects. The methodology applies multiple-criteria decision making. The study includes 47 projects (collectors) and 12 criteria to evaluate them. These criteria represent the different issues considered in the prioritization of the projects, which are structural, hydraulic, environmental, financial, social and technical. The analytic hierarchy process (AHP) is used to determine weights of the criteria and the Preference Ranking Organization Method for Enrichment Evaluations (PROMETHEE II) method is used to obtain the final ranking of the projects. The model was verified using the sewer data of Algiers. The results have shown that the method can be used for prioritizing sewer rehabilitation projects.

  12. Project inspection using mobile technology - phase II : assessing the impacts of mobile technology on project inspection.

    Science.gov (United States)

    2015-01-01

    As mobile technology becomes widely available and affordable, transportation agencies can use this : technology to streamline operations involved within project inspection. This research, conducted in two : phases, identified opportunities for proces...

  13. Research Ship Aurora Australis Underway Meteorological Data, Quality Controlled

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Research Ship Aurora Australis Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and Oceanographic...

  14. Review of the water management systems in the Gujarat Medium Irrigation II Project (Credit 1496-IN)

    NARCIS (Netherlands)

    Brouwer, R.

    1993-01-01

    Different activities are ongoing in the Medium Irrigation II project simultaneously. These are: - emancipation of farmers through their involvement in the operation and management; - change over from Sheshpali type water management to RWS type water management; - design and construction of remaining

  15. 76 FR 55947 - Industrial Relations Promotion Project, Phase II in Vietnam

    Science.gov (United States)

    2011-09-09

    ... DEPARTMENT OF LABOR Office of the Secretary Industrial Relations Promotion Project, Phase II in... to perform the type of activity to be funded.. DAI, through its Industrial Relations Promotion... provided a letter in support of continued funding of DAI/IRRP based, on part, on the importance of the...

  16. DECOVALEX II PROJECT. Technical report - Task 1A and 1B

    International Nuclear Information System (INIS)

    Lanru Jing; Stephansson, Ove; Kautsky, F.

    1998-08-01

    DECOVALEX II project started in November 1995 as a continuation of the DECOVALEX I project, which was completed at the end of 1994. The project was initiated by recognizing the fact that a proper evaluation of the current capacities of numerical modelling of the coupled T-H-M processes in fractured media is needed not only for small scale, well controlled laboratory test cases such as those studied in DECOVALEX I, but also for less characterised, more complex and realistic in-situ experiments. This will contribute to validation and confidence building in the current mathematical models, numerical methods and computer codes. Four tasks were defined in the DECOVALEX II project: TASK 1 - numerical study of the RCF3 pumping test and shaft excavation at Sellafield by Nirex, UK; TASK 2 - numerical study of the in-situ T-H-M experiments at Kamaishi Mine by PNC, Japan; TASK 3 - review of current state-of-the-art of rock joint research and TASK 4 - report on the coupled T-H-M issues related to repository design and performance assessment. This report is one of the technical reports of the DECOVALEX II project, describing the work performed for TASK 1A and 1B - the predictions and model calibrations for the RCF 3 pumping test at Sellafield. Presented in this report are the descriptions of the project, tasks, approaches, methods and results of numerical modelling work carried out by the research teams. The report is a summary of the research reports written by the research teams and submitted to the project secretariat, and the discussions held during project workshops and task force group meetings. The opinions and conclusions in this report, however, reflect only ideas of the authors, not necessarily a collective representation of the funding organisations of the project

  17. Low latitude aurorae on October 21, 1989, 2

    International Nuclear Information System (INIS)

    Kuwashima, Masayuki; Tsunomura, Satoru; Uwai, Tetsuya; Saito, Buniti; Takahasi, Tosiyasu; Kiyama, Yositaka.

    1990-01-01

    Appearance of low-latitude aurorae was seen in Hokkaido, a northern district in Japan, on October 21 and November 17, 1989, during severe magnetic storms. Some characteristics of the associated magnetic variations are shown and discussed in the present short report. The appearance of low-latitude aurora events was found during a time interval of a sharp H-component increase succeeding to the maximum development of the storm time ring current. The cause of the increase in the H-component seems to be associated with the bay disturbance because Pi2 magnetic pulsations were always associated with the low-latitude aurora event. The period of an aurora associated Pi2 event is shorter (40-60 seconds) than that of a usual Pi2 event (100 seconds). During the main phase of geomagnetic storm on October 21, optical and spectroscopic observations of low latitude aurora were made with an airglow-photometer, spectrograph and an all sky camera at Niigata (latitude 37.7degN, longitude 138.8degE and geomagnetic latitude 27.7degN). Spectra of low latitude aurorae observed in Niigata are given and discussed. A model for the main part of the auroral emission is also presented. (N.K.)

  18. The neutron utilization and promotion program of TRR-II research reactor project in Taiwan

    International Nuclear Information System (INIS)

    Gone, J.K.; Huang, Y.H.

    2001-01-01

    The objective of the Taiwan research reactor system improvement and utilization promotion project is to reconstruct the old Taiwan research reactor (TRR), which was operated by the Institute of Nuclear Energy Research (INER) between 1973 and 1988, into a multi-purpose medium flux research reactor (TRR-II). The project started in 1998, and the new reactor is scheduled to have its first critical in June of 2006. The estimated maximum unperturbed thermal neutron flux (E 14 n/cm 2 sec, and it is about one order of magnitude higher than other operating research reactors in Taiwan. The new reactor will equip with secondary neutron sources to provide neutrons with different energies, which will be an essential tool for advanced material researches in Taiwan. One of the major tasks of TRR-II project is to promote domestic utilization of neutrons generated at TRR-II. The traditional uses of neutrons in fuel/material research, trace element analysis, and isotope production has been carried out at INER for many years. On the other hand, it is obvious that promotions of neutron spectrometric technique will be a major challenge for the project team. The limited neutron flux from operating research reactors had discouraged domestic users in developing neutron spectrometric technique for many years, and only few researchers in Taiwan are experienced in using spectrometers. It is important for the project team to encourage domestic researchers to use neutron spectrometers provided by TRR-II as a tool for their future researches in various fields. This paper describes the current status of TRR-II neutron utilization and promotion program. The current status and future plans for important issues such as staff recruiting, personnel training, international collaboration, and promotion strategy will be described. (orig.)

  19. AURORA BOREALIS: a polar-dedicated European Research Platform

    Science.gov (United States)

    Wolff-Boenisch, Bonnie; Egerton, Paul; Thiede, Joern; Roberto, Azzolini; Lembke-Jene, Lester

    2010-05-01

    Polar research and in particular the properties of northern and southern high latitude oceans are currently a subject of intense scientific debate and investigations, because they are subject to rapid and dramatic climatic variations. Polar regions react more rapidly and intensively to global change than other regions of the earth. A shrinking of the Arctic sea-ice cover, potentially leading to an opening of sea passages to the north of North America and Eurasia, on the long to a "blue" Arctic Ocean would additionally have a strong impact on transport, commerce and tourism bearing potential risk for humans and complex ecosystems in the future. In spite of their critical role processes and feedbacks, especially in winter but not exclusively, are virtually unknown: The Arctic Ocean for example, it is the only basin of the world's oceans that has essentially not been sampled by the drill ships of the Deep-Sea Drilling Project (DSDP) or the Ocean Drilling Program (ODP) and its long-term environmental history and tectonic structure is therefore poorly known. Exceptions are the ODP Leg 151 and the more recent very successful ACEX-expedition of the Integrated Ocean Drilling Program (IODP) in 2004. To help to address the most pressing questions regarding climate change and related processes, a Pan-European initiative in the field of Earth system science has been put in place: AURORA BOREALIS is the largest environmental research infrastructure on the ESFRI roadmap of the European Community. AURORA BOREALIS is a very powerful research icebreaker, which will enable year-round operations in the Arctic and the Antarctic as well as in the adjacent ocean basins. Equipped with its drilling rig, the vessel is also capable to explore the presently completely unknown Arctic deep-sea floor. Last but not least, the ship is a floating observatory and mobile monitoring platform that permits to measure on a long-term basis comprehensive time series in all research fields relevant to

  20. Performance improvement with ISO 9001:2000: a case of PKOC-II project

    Energy Technology Data Exchange (ETDEWEB)

    Behera, U.K.; Prasad, K.S.N. [Singareni Collieries Co. Ltd. (India)

    2006-07-01

    The present study is limited to the study of main step towards ISO 9001:2000 (QMS) development, implementation and improvements of PKOC-II project and the same are discussed. In line with increasing global concern for quality, environmental protection and occupational health and safety, Singareni Collieries Co. Ltd (SCCL) has taken the strategic decision to implement ISO 9001:2000 (QMS), ISO 14001:2004 EMS (environmental management system) and occupational health and safety assessment series 18001:1999 (OHSAS) at the PK OC-II project. This is the first project to implement all three management systems QMS, OHSAS, and EMS, in the Indian coal industry. 25 refs., 12 figs., 2 tabs.

  1. DECOVALEX II PROJECT. Technical report - Task 2A and 2B. (Revised edition)

    International Nuclear Information System (INIS)

    Lanru Jing; Stephansson, Ove

    1998-08-01

    DECOVALEX II project started in November 1995 as a continuation of the DECOVALEX I project, which was completed at the end of 1994. The project was initiated by recognizing the fact that a proper evaluation of the current capacities of numerical modelling of the coupled T-H-M processes in fractured media is needed not only for small scale, well controlled laboratory test cases such as those studied in DECOVALEX 1, but also for less characterised, more complex and realistic in-situ experiments. This will contribute to validation and confidence building in the current mathematical models, numerical methods and computer codes. Four tasks were defined in the DECOVALEX II project: TASK 1 - numerical study of the RCF3 pumping test and shaft excavation at Sellafield by Nirex, UK; TASK 2 - numerical study of the in-situ T-H-M experiments at Kamaishi Mine by PNC, Japan; TASK 3 - review of current state-of-the-art of rock joint research and TASK 4 - report on the coupled T-H-M issues related to repository design and performance assessment. This report is one of the technical reports of the DECOVALEX II project, describing the work performed for TASK 2A and 2B - the predictions and model calibration for the hydro-mechanical effect of the excavation of the test pit for the in-situ T-H-M experiments at Kamaishi Mine by PNC, Japan. Presented in this report are the descriptions of the project, definition of Task 2, and approaches, methods and results of numerical modelling work carried out by the research teams. The report is a summary of the research reports written by the research teams and the discussions held during project workshops and task force group meetings. The opinions and conclusions in this report, however, reflect only ideas of the authors, not necessarily a collective representation of the funding organisations of the project

  2. Phase II Final Project Report SBIR Project: "A High Efficiency PV to Hydrogen Energy System"

    Energy Technology Data Exchange (ETDEWEB)

    Slade, A; Turner, J; Stone, K; McConnell, R

    2008-09-02

    The innovative research conducted for this project contributed greatly to the understanding of generating low-cost hydrogen from solar energy. The project’s research identified two highly leveraging and complementary pathways. The first pathway is to dramatically increase the efficiency of converting sunlight into electricity. Improving solar electric conversion efficiency directly increases hydrogen production. This project produced a world record efficiency for silicon solar cells and contributed to another world record efficiency for a solar concentrator module using multijunction solar cells. The project’s literature review identified a second pathway in which wasted heat from the solar concentration process augments the electrolysis process generating hydrogen. One way to do this is to use a “heat mirror” that reflects the heat-producing infrared and transmits the visible spectrum to the solar cells; this also increases solar cell conversion efficiency. An economic analysis of this concept confirms that, if long-term concentrator photovoltaic (CPV) and solid-oxide electrolyzer cost goals can be achieved, hydrogen will be produced from solar energy cheaper than the cost of gasoline. The potential public benefits from this project are significant. The project has identified a potential energy source for the nation’s future electricity and transportation needs that is entirely “home grown” and carbon free. As CPV enter the nation’s utility markets, the opportunity for this approach to be successful is greatly increased. Amonix strongly recommends further exploration of this project’s findings.

  3. Aurora B kinase inhibition in mitosis: strategies for optimising the use of aurora kinase inhibitors such as AT9283.

    Science.gov (United States)

    Curry, Jayne; Angove, Hayley; Fazal, Lynsey; Lyons, John; Reule, Matthias; Thompson, Neil; Wallis, Nicola

    2009-06-15

    Aurora kinases play a key role in regulating mitotic division and are attractive oncology targets. AT9283, a multi-targeted kinase inhibitor with potent activity against Aurora A and B kinases, inhibited growth and survival of multiple solid tumor cell lines and was efficacious in mouse xenograft models. AT9283-treatment resulted in endoreduplication and ablation of serine-10 histone H3 phosphorylation in both cells and tumor samples, confirming that in these models it acts as an Aurora B kinase inhibitor. In vitro studies demonstrated that exposure to AT9283 for one complete cell cycle committed an entire population of p53 checkpoint-compromised cells (HCT116) to multinucleation and death whereas treatment of p53 checkpoint-competent cells (HMEC, A549) for a similar length of time led to a reversible arrest of cells with 4N DNA. Further studies in synchronized cell populations suggested that exposure to AT9283 during mitosis was critical for optimal cytotoxicity. We therefore investigated ways in which these properties might be exploited to optimize the efficacy and therapeutic index of Aurora kinase inhibitors for p53 checkpoint compromised tumors in vivo. Combining Aurora B kinase inhibition with paclitaxel, which arrests cells in mitosis, in a xenograft model resulted in promising efficacy without additional toxicity. These findings have implications for optimizing the efficacy of Aurora kinase inhibitors in clinical practice.

  4. Advanced Instrumentation, Information and Control (II&C) Research and Development Facility Buildout and Project Execution of LWRS II&C Pilot Projects 1 and 3

    Energy Technology Data Exchange (ETDEWEB)

    Ronald Farris; Johanna Oxstrand; Gregory Weatherby

    2011-09-01

    The U.S. Department of Energy (DOE) is sponsoring research, development, and deployment on light water reactor sustainability (LWRS), in which the Idaho National Laboratory (INL) is working closely with nuclear utilities to develop technologies and solutions to help ensure the safe operational life extension of current reactors. As technologies are introduced that change the operation of the plant, the LWRS pilot projects can help identify their best-advanced uses and help demonstrate the safety of these technologies. In early testing of operator performance given these emerging technologies will ensure the safety and usability of systems prior to large-scale deployment and costly verification and validation at the plant. The aim of these collaborations, demonstrations, and approaches are intended to lessen the inertia that sustains the current status quo of today's II&C systems technology, and to motivate transformational change and a shift in strategy to a long-term approach to II&C modernization that is more sustainable. Research being conducted under Pilot Project 1 regards understanding the conditions and behaviors that can be modified, either through process improvements and/or technology deployment, to improve the overall safety and efficiency of outage control at nuclear facilities. The key component of the research in this pilot project is accessing the delivery of information that will allow researchers to simulate the control room, outage control center (OCC) information, and plant status data. The simulation also allows researchers to identify areas of opportunity where plant operating status and outage activities can be analyzed to increase overall plant efficiency. For Pilot Project 3 the desire is to demonstrate the ability of technology deployment and the subsequent impact on maximizing the 'Collective Situational Awareness' of the various stakeholders in a commercial nuclear power plant. Specifically, the desire is to show positive

  5. Advanced Instrumentation, Information and Control (II and C) Research and Development Facility Buildout and Project Execution of LWRS II and C Pilot Projects 1 and 3

    International Nuclear Information System (INIS)

    Farris, Ronald; Oxstrand, Johanna; Weatherby, Gregory

    2011-01-01

    The U.S. Department of Energy (DOE) is sponsoring research, development, and deployment on light water reactor sustainability (LWRS), in which the Idaho National Laboratory (INL) is working closely with nuclear utilities to develop technologies and solutions to help ensure the safe operational life extension of current reactors. As technologies are introduced that change the operation of the plant, the LWRS pilot projects can help identify their best-advanced uses and help demonstrate the safety of these technologies. In early testing of operator performance given these emerging technologies will ensure the safety and usability of systems prior to large-scale deployment and costly verification and validation at the plant. The aim of these collaborations, demonstrations, and approaches are intended to lessen the inertia that sustains the current status quo of today's II and C systems technology, and to motivate transformational change and a shift in strategy to a long-term approach to II and C modernization that is more sustainable. Research being conducted under Pilot Project 1 regards understanding the conditions and behaviors that can be modified, either through process improvements and/or technology deployment, to improve the overall safety and efficiency of outage control at nuclear facilities. The key component of the research in this pilot project is accessing the delivery of information that will allow researchers to simulate the control room, outage control center (OCC) information, and plant status data. The simulation also allows researchers to identify areas of opportunity where plant operating status and outage activities can be analyzed to increase overall plant efficiency. For Pilot Project 3 the desire is to demonstrate the ability of technology deployment and the subsequent impact on maximizing the 'Collective Situational Awareness' of the various stakeholders in a commercial nuclear power plant. Specifically, the desire is to show positive results

  6. Dancing Lights: Creating the Aurora Story

    Science.gov (United States)

    Wood, E. L.; Cobabe-Ammann, E. A.

    2009-12-01

    Science tells a story about our world, our existence, our history, and the larger environment our planet occupies. Bearing this in mind, we created a series of lessons for 3rd-5th grades using a cross-disciplinary approach to teaching about the aurora by incorporating stories, photos, movies, and geography into the science in order to paint a broad picture and answer the question, “why do we care?” The fundamental backbone of the program is literacy. Students write and illustrate fiction and non-fiction work, poetry, and brochures that solidify both language arts skills and science content. In a time when elementary teachers relegate science to less than one hour per week, we have developed a novel science program that can be easily integrated with other topics during the typical school day to increase the amount of science taught in a school year. We are inspiring students to take an interest in the natural world with this program, a stepping-stone for larger things.

  7. LIFAC sorbent injection desulfurization demonstration project. Final report, volume II: Project performance and economics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-01-01

    This publication discusses the demonstration of the LIFAC sorbent injection technology at Richmond Power and Light`s Whitewater Valley Unit No. 2, performed under the auspices of the U.S. Department of Energy`s (DOE) Clean Coal Technology Program. LIFAC is a sorbent injection technology capable of removing 75 to 85 percent of a power plant`s SO{sub 2} emissions using limestone at calcium to sulfur molar ratios of between 2 and 2.5 to 1. The site of the demonstration is a coal-fired electric utility power plant located in Richmond, Indiana. The project is being conducted by LIFAC North America (LIFAC NA), a joint venture partnership of Tampella Power Corporation and ICF Kaiser Engineers, in cooperation with DOE, RP&L, and Research Institute (EPRI), the State of Indiana, and Black Beauty Coal Company. The purpose of Public Design Report Volume 2: Project Performance and Economics is to consolidate, for public use, the technical efficiency and economy of the LIFAC Process. The report has been prepared pursuant to the Cooperative Agreement No. DE-FC22-90PC90548 between LIFAC NA and the U.S. Department of Energy.

  8. Decontamination and decommissioning project status of the TRIGA Mark II and III in Korea

    International Nuclear Information System (INIS)

    Paik, S.T.; Park, S.K.; Chung, K.W.; Chung, U.S.; Jung, K.J.

    1999-01-01

    TRIGA Mark-II, the first research reactor in Korea, has operated since 1962, and the second one, TRIGA Mark-III since 1972. Both of them had their operation phased out in 1995 due to their lives and operation of the new research reactor, HANARO (High-flux Advanced Neutron Application Reactor) at the Korea Atomic Energy Institute (KAERI) in Taejon. Decontamination and decommissioning (D and D) project of TRIGA Mark-II and Mark-III was started in January 1997 and will be completed in December 2002. The first year of the project, work was performed in preparation of the decommissioning plan, start of the environmental impact assessment and setup licensing procedure and documentation for the project with cooperation of Korea Institute of Nuclear Safety (KINS). Hyundai Engineering Company (HEC) is the main contractor to do design and licensing documentation for the D and D of both reactors. British Nuclear Fuels plc (BNFL) is the technical assisting partner of HEC. The decommissioning plan document was submitted to the Ministry of Since and Technology (MOST) for the decommissioning license in December 1998, and it expecting to be issued a license in mid 1999. The goal of this project is to release the reactor site and buildings as an unrestricted area. This paper summarizes current status and future plan for the D and D project. (author)

  9. HIFS VNL Monthly Progress Report Preparation for NDCX-II Project

    International Nuclear Information System (INIS)

    Logan, Grant; Kwan, Joe; Barnard, John; Friedman, Alex; Gilson, Erik; Leitner, Matthaeus; Waldron, Will; Bieniosek, Frank

    2009-01-01

    In preparation for the project and for anticipated review in August, the HIFS-VNL hosted an NDCX-II Advisory Meeting at LBNL on May 27, 2009. A number of experts in accelerator physics, engineering, and construction were asked to visit for a full day, listen to presentations on the project, its goals, and its status, and to offer their advice on how best to proceed, what topics needed attention, and what technical options seemed most attractive to them. This was a productive meeting, and the Committee's comments will provide useful guidance.

  10. Project Monitor: Part II. Conservation in small business: an exploratory study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hammond, P Y

    1979-08-01

    Project Monitor examined the energy conservation attitude and behavior of small samples of small business owners/operators in Allegheny County, Pennsylvania, focusing on manufacturing concerns and retailers. Section I reports the findings on the energy conserving behavior of 92 smaller manufacturers and Section II identifies the factors which affect decision making concerning energy consuming activities by the owners/operators of 94 small retail establishments. In each, the impact of Project Pacesetter and of the coal strike and the general energy situation is considered. (MCW)

  11. Implementation of MOAS II diagnosis system at the OECD Halden Reactor project

    International Nuclear Information System (INIS)

    Kim, I.S.; Grini, R.E.; Nilsen, S.

    1995-01-01

    MOAS II is a surveillance and diagnosis system that uses several techniques for knowledge acquisition and diagnostic reasoning, e.g., goal tree-success tree, simplified directed graphs, diagnosis trees, and detailed knowledge of the process, such as mass or energy balance. This new approach was used at the Halden Man-Machine Laboratory of the OECD Halden Reactor Project. The performance of MOAS II, developed in G2 real-time expert system shell for the high-pressure preheaters of the NORS process, was tested against a variety of transient scenarios, including failures of control valves and sensors, and leakage of tubes of the preheaters. These tests showed that MOAS II successfully carried out its intended functions, i.e., quickly recognizing an occurring disturbance, correctly diagnosing its cause, and presenting advice on its control to the operator. The insights gained during the implementation are discussed

  12. Relation between fine structure of energy spectra for pulsating aurora electrons and frequency spectra of whistler mode chorus waves

    Czech Academy of Sciences Publication Activity Database

    Miyoshi, Y.; Saito, S.; Seki, K.; Nishiyama, T.; Kataoka, R.; Asamura, K.; Katoh, Y.; Ebihara, Y.; Sakanoi, T.; Hirahara, M.; Oyama, S.; Kurita, S.; Santolík, Ondřej

    2015-01-01

    Roč. 120, č. 9 (2015), s. 7728-7736 ISSN 2169-9380 R&D Projects: GA MŠk LH12231 Institutional support: RVO:68378289 Keywords : pulsating aurora * chorus waves * wave-particle interactions * computer simulation * Reimei satellite Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 3.318, year: 2015 http://onlinelibrary.wiley.com/doi/10.1002/2015JA021562/full

  13. Aurora Borealis, A Painting by Frederic Edwin Church

    Science.gov (United States)

    Love, J. J.

    2015-12-01

    This year marks the sesquicentennial anniversary of the end of the American Civil War. In 1865, the same year as the War's end, the great American landscape artist, Frederic Edwin Church, unveiled Aurora Borealis, a painting that depicts a fantastic, far-northern place, an auroral arch stretched across a quiet night-time sky, above dark mountains and a frozen sea. Church was born in Connecticut, lived in New York, and traveled to Labrador; he would have often seen the northern lights. Church might have also been influenced by the spectacular displays of aurora that were caused by some unusually intense magnetic storms in 1859. Aurora Borealis can certainly be interpreted in terms of 19th-century romanticism, scientific philosophy, and Arctic missions of exploration, all subjects of interest to Church. As with so many of his paintings, Church's meticulous attention to detail in Aurora Borealis reveals his deep admiration of nature. But his depiction of auroral light is a curious and possibly intentional departure from natural verisimilitude. Some art historians have suggested that Church painted Aurora Borealis as a subdued tribute to the end of the Civil War, with the drapery of auroral light forming an abstract representation of the American flag. If so, then colors of the flag have been unfurled across a cold and barren landscape, not in extravagant celebration, but in somber recognition of the reality of post-war desolation and an uncertain future.

  14. Observed Type II supernova colours from the Carnegie Supernova Project-I

    Science.gov (United States)

    de Jaeger, T.; Anderson, J. P.; Galbany, L.; González-Gaitán, S.; Hamuy, M.; Phillips, M. M.; Stritzinger, M. D.; Contreras, C.; Folatelli, G.; Gutiérrez, C. P.; Hsiao, E. Y.; Morrell, N.; Suntzeff, N. B.; Dessart, L.; Filippenko, A. V.

    2018-06-01

    We present a study of observed Type II supernova (SN II) colours using optical/near-infrared photometric data from the Carnegie Supernovae Project-I. We analyse four colours (B - V, u - g, g - r, and g - Y) and find that SN II colour curves can be described by two linear regimes during the photospheric phase. The first (s1, colour) is steeper and has a median duration of ˜40 d. The second, shallower slope (s2, colour) lasts until the end of the `plateau' (˜80 d). The two slopes correlate in the sense that steeper initial colour curves also imply steeper colour curves at later phases. As suggested by recent studies, SNe II form a continuous population of objects from the colour point of view as well. We investigate correlations between the observed colours and a range of photometric and spectroscopic parameters including the absolute magnitude, the V-band light-curve slopes, and metal-line strengths. We find that less luminous SNe II appear redder, a trend that we argue is not driven by uncorrected host-galaxy reddening. While there is significant dispersion, we find evidence that redder SNe II (mainly at early epochs) display stronger metal-line equivalent widths. Host-galaxy reddening does not appear to be a dominant parameter, neither driving observed trends nor dominating the dispersion in observed colours. Intrinsic SN II colours are most probably dominated by photospheric temperature differences, with progenitor metallicity possibly playing a minor role. Such temperature differences could be related to differences in progenitor radius, together with the presence or absence of circumstellar material close to the progenitor stars.

  15. Technical realisation of the VISA-II project, phase I, part IV, IZ-165-o268-1962

    International Nuclear Information System (INIS)

    Pavicevic, M.

    1962-12-01

    Project VISA-II is described in IX chapters as follows: introduction, definition of experiments and possibilities of performance; VISA-II channel, new experimental space in the RA reactor; hydraulic tests in the VISA-II channel; measurement of fast neutron and gamma flux in VISA-II channels; measurement of water flow through different VISA-2 irradiation capsules; fabrication of VISA-II capsules; corrosion and heavy water purity problems; safety problems of experiment VISA-2; experimental operation of VISA-II. This chapter VI includes documentation for each type of capsule, review about each experiment within the VISA-II project, the objective and purpose of the experiment as well as experimental device [sr

  16. Ionospheric response to particle precipitation within aurora

    International Nuclear Information System (INIS)

    Wahlund, J.E.

    1992-03-01

    The aurora is just the visible signature of a large number of processes occurring in a planetary ionosphere as a response to energetic charged particles falling in from the near-empty space far above the planetary atmosphere. This thesis, based on measurements using the EISCAT incoherent scatter radar system in northern Scandinavia, discusses ionospheric response processes and especially a mechanism leading to atmospheric gas escape from a planet. One of the most spectacular events in the high latitude atmosphere on earth are the 'auroral arcs' - dynamic rayed sheets of light. An investigation of the conditions of the ionosphere surrounding auroral arcs shows that strong field-aligned bulk ion outflows appear in the topside ionosphere which account for a large fraction of the escape of atmospheric oxygen from earth. Four different additional ionospheric responses are closely related to this ion outflow; 1. enhanced electron temperatures of several thousand Kelvin above an altitude of about 250 km, 2. enhanced ionization around an altitude of 200 km corresponding to electron precipitation with energies of a few hundred eV, 3. the occurrence of naturally enhanced ion acoustic fluctuations seen in the radar spectrum, most likely produced by an ion-ion two-stream instability, and 4. upward directed field-aligned currents partly carried by the outflowing ions. From these observations, it is suggested that the energy dissipation into the background plasma through Joule heating, the production of a few hundred eV energetic run-away electrons, and strong ion outflows are partly produced by the simultaneous presence of ion acoustic turbulence and field-aligned currents above auroral arcs. (20 refs.) (au)

  17. Characterization of unpaved road condition through the use of remote sensing project - phase II, deliverable 8-D: final report.

    Science.gov (United States)

    2016-03-07

    Building on the success of developing a UAV based unpaved road assessment system in Phase I, the project team was awarded a Phase II project by the USDOT to focus on outreach and implementation. The project team added Valerie Lefler of Integrated Glo...

  18. Aurora Flight Sciences' Perseus B Remotely Piloted Aircraft in Flight

    Science.gov (United States)

    1998-01-01

    A long, slender wing and a pusher propeller at the rear characterize the Perseus B remotely piloted research aircraft, seen here during a test flight in June 1998. Perseus B is a remotely piloted aircraft developed as a design-performance testbed under NASA's Environmental Research Aircraft and Sensor Technology (ERAST) project. Perseus is one of several flight vehicles involved in the ERAST project. A piston engine, propeller-powered aircraft, Perseus was designed and built by Aurora Flight Sciences Corporation, Manassas, Virginia. The objectives of Perseus B's ERAST flight tests have been to reach and maintain horizontal flight above altitudes of 60,000 feet and demonstrate the capability to fly missions lasting from 8 to 24 hours, depending on payload and altitude requirements. The Perseus B aircraft established an unofficial altitude record for a single-engine, propeller-driven, remotely piloted aircraft on June 27, 1998. It reached an altitude of 60,280 feet. In 1999, several modifications were made to the Perseus aircraft including engine, avionics, and flight-control-system improvements. These improvements were evaluated in a series of operational readiness and test missions at the Dryden Flight Research Center, Edwards, California. Perseus is a high-wing monoplane with a conventional tail design. Its narrow, straight, high-aspect-ratio wing is mounted atop the fuselage. The aircraft is pusher-designed with the propeller mounted in the rear. This design allows for interchangeable scientific-instrument payloads to be placed in the forward fuselage. The design also allows for unobstructed airflow to the sensors and other devices mounted in the payload compartment. The Perseus B that underwent test and development in 1999 was the third generation of the Perseus design, which began with the Perseus Proof-Of-Concept aircraft. Perseus was initially developed as part of NASA's Small High-Altitude Science Aircraft (SHASA) program, which later evolved into the ERAST

  19. TV morphology of some episodes of pulsating auroras

    International Nuclear Information System (INIS)

    Vallance Jones, A.; Gattinger, R.L.

    1981-01-01

    Sets of all-sky TV images of pulsating auroras obtained during the displays through which the sounding rockets of the Pulsating Aurora Campaign were fired are presented and discussed. It is emphasized that these displays are considerably more complex and variable than might seem to be the case on the basis of zenith photometer records. The pulsation modulation pattern was observed to be travelling westward during the first flight; later in the same display this apparent motion ceased. For the second flight the pulsation modulation pattern was almost stationary. (auth)

  20. Relative drift between black aurora and the ionospheric plasma

    Directory of Open Access Journals (Sweden)

    E. M. Blixt

    2005-07-01

    Full Text Available Black auroras are recognized as spatially well-defined regions within uniform diffuse aurora where the optical emission is significantly reduced. Although a well studied phenomenon, there is no generally accepted theory for black auroras. One theory suggests that black regions are formed when energetic magnetospheric electrons no longer have access to the loss cone. If this blocking mechanism drifts with the source electron population in the magnetosphere, black auroras in the ionosphere should drift eastward with a velocity that increases with the energy of the precipitating electrons in the surrounding aurora, since the gradient-B curvature drift is energy dependent. It is the purpose of this paper to test this hypothesis. To do so we have used simultaneous measurements by the European Incoherent Scatter (EISCAT radar and an auroral TV camera at Tromsø, Norway. We have analyzed 8 periods in which a black aurora occurred frequently to determine their relative drift with respect to the ionospheric plasma. The black aurora was found to drift eastward with a velocity of 1.5–4km/s, which is in accordance with earlier observations. However, one case was found where a black patch was moving westward, this being the first report of such behaviour in the literature. In general, the drift was parallel to the ionospheric flow but at a much higher velocity. This suggests that the generating mechanism is not of ionospheric origin. The characteristic energy of the precipitating electron population was estimated through inversion of E-region plasma density profiles. We show that the drift speed of the black patches increased with the energy of the precipitating electrons in a way consistent with the gradient-B curvature drift, suggesting a magnetospheric mechanism for the black aurora. As expected, a comparison of the drift speeds with a rudimentary dipole field model of the gradient-B curvature drift speed only yields order-of-magnitude agreement, which

  1. Navigation GPS/GLONASS in the Arctic and aurora

    Directory of Open Access Journals (Sweden)

    Chernouss S. A.

    2016-12-01

    Full Text Available The correspondence of the time-spatial distribution of the radiances of the aurora oval and time-spatial changes in the parameters of the navigation satellites' signal has been shown. For this aim the experimental data on the regional and local heterogeneities of the Total Electron Content (or TEC and the data on the signal delays in the polar ionosphere have been analyzed. Using the data concerning aurora as the indicator of disturbances in the work of the GPS/GLONASS systems can give the opportunity to increase considerably the accuracy of positioning in the Arctic with the help of satellite navigation systems (SNS.

  2. IAEA fast reactor knowledge preservation initiative. Project focus: KNK-II reactor, Karlsruhe, Germany

    International Nuclear Information System (INIS)

    2004-08-01

    This Working Material (including the attached CD-ROM) documents progress made in the IAEA's initiative to preserve knowledge in the fast reactor domain. The brochure describes briefly the context of the initiative and gives an introduction to the contents of the CD-ROM. In 2003/2004 a first focus of activity was concentrated on the preservation of knowledge related to the KNK-II experimental fast reactor in Karlsruhe, Germany. The urgency of this project was given by the impending physical destruction of the installation, including the office buildings. Important KNK-II documentation was brought to safety and preserved just in time. The CD-ROM contains the full texts of 264 technical and scientific documents describing research, development and operating experience gained with the KNK-II installation over a period of time from 1965 to 2002, extending through initial investigations, 17 years of rich operating experience, and final shutdown and decommissioning. The index to the documents on the CD-ROM is printed at the end of this booklet in chronological order and is accessible on the CD by subject index and chronological index. The CD-ROM contains in its root directory also the document 'fr c lassification.pdf' which describes the classification system used for the present collection of documents on the fast reactor KNK-II

  3. Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases

    Directory of Open Access Journals (Sweden)

    Wang Liu

    2016-11-01

    Full Text Available Abstract Background Overexpression of Aurora A and B has been reported in a wide range of tumor types, including gastric cancer. Anti-angiogenesis has been considered as an important therapeutic modality in advanced gastric cancer. Here we identified a novel compound TY-011 with promising antitumor activity by targeting mitotic kinases (Aurora A and B and angiogenic receptor tyrosine kinase (VEGFR2. Methods HTRF® KinEASE™ assay was used to detect the effect of TY-011 against Aurora A, Aurora B and VEGFR2 activities. Docking simulation study was performed to predict the binding mode of TY-011 with Aurora A and B kinases. CCK-8 assay was used to test cell growth. Cell cycle and cell apoptosis was analyzed by flow cytometry. Gastric cancer cell xenograft mouse models were used for in vivo study. TUNEL kit was used to determine the apoptosis of tumor tissues. Immunohistochemistry analysis and HUVEC tube formation assay were performed to determine the anti-angiogenesis ability. Immunofluorescence and western blot were used to test protein expression. Results TY-011 was identified as a potential Aurora A and B inhibitor by HTRF® KinEASE™ assay. It effectively inhibited cellular Aurora A and B activities in a concentration-dependent manner. TY-011 occupied the ATP-binding site of both Aurora A and B kinases. TY-011 demonstrated prominent inhibitory effects on proliferation of gastric cancer cells. TY-011 treatment induced an obvious accumulation of cells at G2/M phase and a modest increase of cells with >4 N DNA content, which then underwent apoptosis. Meaningfully, orally administration of TY-011 demonstrated superior efficacy against the tumor growth in gastric cancer cell xenograft, with ~90% inhibition rate and 100% tumor regression at 9 mg/kg dose, and TY-011 did not affect the body weight of mice. Interestingly, we observed that TY-011 also antagonized tumor angiogenesis by targeting VEGFR2 kinase. Conclusions These results indicate that

  4. Technical realisation of the VISA-II Project, Phase II, Chapter X, Vol. VI; Tehnicka realizacija projekta VISA-II, II faza, Glava X, Album VI

    Energy Technology Data Exchange (ETDEWEB)

    Pavicevic, M; Nikolic, M [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1963-01-15

    The second phase of the 'Project VISA-2 described in this chapter of Vol. VI includes the project specifications and technical drawings of the 'measuring system of VISA-2 for testing the VISA-2 channels outside and in the reactor'. In addition to the task objective, description of the measuring system, action plan, description of the work done it contains the definition of the task 'Leak testing' and instructions for the instrumentation personnel on duty. [Serbo-Croat] Druga faza zadatka {sup T}ehnicka realizacija projekta VISA-2' opisana u ovom poglavlju Albuma VI, sadrzi tehnicki opis i crteze 'Mernog sistema VISA-2 i ispitivanje kanala VISA-2 van reaktora i u reaktoru'. Pored definicije zadatka, opisa mernog sistema VISA-2, razrade zadatka, tekstualnog dela projekta i opisa izvedenih radova, ovo poglavlje obuhvata definiciju i razradu podzadatka 'Ispitivanje hermeticnosti' i dodatak sa instrukcijama za dezurne instrumentatore u vezi eksperimenta VISA-2.

  5. Computerized transportation model for the NRC Physical Protection Project. Versions I and II

    International Nuclear Information System (INIS)

    Anderson, G.M.

    1978-01-01

    Details on two versions of a computerized model for the transportation system of the NRC Physical Protection Project are presented. The Version I model permits scheduling of all types of transport units associated with a truck fleet, including truck trailers, truck tractors, escort vehicles and crews. A fixed-fleet itinerary construction process is used in which iterations on fleet size are required until the service requirements are satisfied. The Version II model adds an aircraft mode capability and provides for a more efficient non-fixed-fleet itinerary generation process. Test results using both versions are included

  6. Nutritive potentials and utilization of garden snail (Limicolaria aurora ...

    African Journals Online (AJOL)

    AJB SERVER

    2006-10-16

    Oct 16, 2006 ... The possibility of using garden snail (Limicolaria aurora) meat meal as a protein source in fish feeds was tested in ... garden snail meat meal was used to replace fish meal at 0%, (control diet), 25, 50, 75 and 100% inclusion ..... Randall DJ, Brett JR (eds) Fish Physiology, Academic Press, NY 8: 279-352,.

  7. Nutritive potentials and utilization of garden snail (Limicolaria aurora ...

    African Journals Online (AJOL)

    The possibility of using garden snail (Limicolaria aurora) meat meal as a protein source in fish feeds was tested in Clarias gariepinus fingerlings. Five isonitrogenous (43% crude protein) diets in which garden snail meat meal was used to replace fish meal at 0%, (control diet), 25, 50, 75 and 100% inclusion levels were used ...

  8. Canine osteosarcoma cells exhibit resistance to aurora kinase inhibitors.

    Science.gov (United States)

    Cannon, C M; Pozniak, J; Scott, M C; Ito, D; Gorden, B H; Graef, A J; Modiano, J F

    2015-03-01

    We evaluated the effect of Aurora kinase inhibitors AZD1152 and VX680 on canine osteosarcoma cells. Cytotoxicity was seen in all four cell lines; however, half-maximal inhibitory concentrations were significantly higher than in human leukaemia and canine lymphoma cells. AZD1152 reduced Aurora kinase B phosphorylation, indicating resistance was not because of failure of target recognition. Efflux mediated by ABCB1 and ABCG2 transporters is one known mechanism of resistance against these drugs and verapamil enhanced AZD1152-induced apoptosis; however, these transporters were only expressed by a small percentage of cells in each line and the effects of verapamil were modest, suggesting other mechanisms contribute to resistance. Our results indicate that canine osteosarcoma cells are resistant to Aurora kinase inhibitors and suggest that these compounds are unlikely to be useful as single agents for this disease. Further investigation of these resistance mechanisms and the potential utility of Aurora kinase inhibitors in multi-agent protocols is warranted. © 2013 Blackwell Publishing Ltd.

  9. Functions of Aurora kinase C in meiosis and cancer

    Directory of Open Access Journals (Sweden)

    Suzanne M. Quartuccio

    2015-08-01

    Full Text Available The mammalian genome encodes three Aurora kinase protein family members: A, B, and C. While Aurora kinase A (AURKA and B (AURKB are found in cells throughout the body, significant protein levels of Aurora kinase C (AURKC are limited to cells that undergo meiosis (sperm and oocyte. Despite its discovery nearly 15 years ago, we know little about the function of AURKC compared to that of the other 2 Aurora kinases. This lack of understanding can be attributed to the high sequence homology between AURKB and AURKC preventing the use of standard approaches to understand non-overlapping and meiosis I (MI-specific functions of the two kinases. Recent evidence has revealed distinct functions of AURKC in meiosis and may aid in our understanding of why chromosome segregation during MI often goes awry in oocytes. Many cancers aberrantly express AURKC, but because we do not fully understand AURKC function in its normal cellular context, it is difficult to predict the biological significance of this expression on the disease. Here, we consolidate and update what is known about AURKC signaling in meiotic cells to better understand why it has oncogenic potential.

  10. Observation and Study of Proton Aurora by using Scanning Photometer

    Science.gov (United States)

    Mochizuki, T.; Ono, T.; Kadokura, A.; Sato, N.

    2009-12-01

    The proton auroras have significant differences from electron auroras in their spectral shape. They show Doppler-shifted and broadened spectra: the spectra have Doppler-shifted (~0.5 nm shorter) peak and both bluewing (~2-4 nm) and redwing (~1.5 nm) extending. Energy spectra of precipitating protons have been estimated from this shape. Recently it is found that the intensity in the extent of the blue wing reflects more effectively by the change of the mean energy of precipitating protons than the shift of peak wavelength [Lanchester et al., 2003]. Another character of the H-beta aurora is that it is diffuse form because a proton becomes hydrogen atom due to a charge-exchange reaction with atmospheric constituent and then possible to move across the magnetic field line. By using a scanning photometer, the movement of the proton auroral belt and change of a spectrum shape associated with the variation of proton source region due to storm and substorm were reported, however, not discussed in detail yet [Deehr and Lummerzheim, 2001]. The purpose of this study is to obtain the detail characteristics of H-beta aurora for understanding of source region of energetic protons in the magnetosphere. For this purpose, a new meridian-scanning photometer (SPM) was installed at Husafell station in Iceland in last summer season and Syowa Station, Antarctica. It will contribute to investigate the distribution of energetic protons and plasma waves which cause the pitch angle scattering in the magnetosphere. The meridian-scanning photometer is able to observe at five wavelengths for H-beta emission. One channel is to measure the background level. By analyzing the data obtained by the SPM, the H-beta spectrum can be estimated by fitting a model function with it. Then it is possible to obtain distribution of precipitating protons in north-south direction. It is also possible to estimate an energy spectrum of precipitating proton, simultaneously. The instrumental parameters of the SPM is

  11. Structural Biology Insight for the Design of Sub-type Selective Aurora Kinase Inhibitors.

    Science.gov (United States)

    Sarvagalla, Sailu; Coumar, Mohane Selvaraj

    2015-01-01

    Aurora kinase A, B and C, are key regulators of mitosis and are over expressed in many of the human cancers, making them an ideal drug target for cancer chemotherapy. Currently, over a dozen of Aurora kinase inhibitors are in various phases of clinical development. The majority of the inhibitors (VX-680/MK-0457, PHA-739358, CYC116, SNS-314, AMG 900, AT-9283, SCH- 1473759, ABT-348, PF-03814735, R-763/AS-703569, KW-2449 and TAK-901) are pan-selective (isoform non-selective) and few are Aurora A (MLN8054, MLN8237, VX-689/MK5108 and ENMD 2076) and Aurora B (AZD1152 and GSK1070916) sub-type selective. Despite the intensive research efforts in the past decade, no Aurora kinase inhibitor has reached the market. Recent evidence suggests that the sub-type selective Aurora kinase A inhibitor could possess advantages over pan-selective Aurora inhibitors, by avoiding Aurora B mediated neutropenia. However, sub-type selective Aurora kinase A inhibitor design is very challenging due to the similarity in the active site among the isoforms. Structural biology and computational aspects pertaining to the design of Aurora kinase inhibitors were analyzed and found that a possible means to develop sub-type selective inhibitor is by targeting Aurora A specific residues (Leu215, Thr217 and Arg220) or Aurora B specific residues (Arg159, Glu161 and Lys164), near the solvent exposed region of the protein. Particularly, a useful strategy for the design of sub-type selective Aurora A inhibitor could be by targeting Thr217 residue as in the case of MLN8054. Further preclinical and clinical studies with the sub-type selective Aurora inhibitors could help bring them to the market for the treatment of cancer.

  12. Environmental compatibility investigation of the Garzweiler II open cast mine project

    International Nuclear Information System (INIS)

    Oster, A.; Gaertner, D.

    1994-01-01

    Based on an EEC directive, the law on the investigation of ecological compatibility came into force in 1990. With the application of these European directives in national law, investigations to determine the ecological compatibility must now be carried out for projects to exploit brown coal. In this connection and in conjunction with the licensing procedure for Garzweiler II, Rheinbraun in 1992 for the first time compiled data on the investigations carried out to determine the ecological compatibility of an open cast mine. The data on these investigations include information on the necessity of the open cast mine and on alternative projects that have been examined, as well as a description of the project in question as regards its nature and extent. As far as the legally specified protected objects are concerned, i.e. people, water, air, nature (animals and plants, soil, climate and landscape) as well as cultural and other material objects, itemized data are furnished on the development and effects of the project and on countermeasures and the planned traffic and transport concept. (orig.) [de

  13. CSNI Project for Fracture Analyses of Large-Scale International Reference Experiments (FALSIRE II)

    Energy Technology Data Exchange (ETDEWEB)

    Bass, B.R.; Pugh, C.E.; Keeney, J. [Oak Ridge National Lab., TN (United States); Schulz, H.; Sievers, J. [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, Koeln (Gemany)

    1996-11-01

    A summary of Phase II of the Project for FALSIRE is presented. FALSIRE was created by the Fracture Assessment Group (FAG) of the OECD/NEA`s Committee on the Safety of Nuclear Installations (CNSI) Principal Working Group No. 3. FALSIRE I in 1988 assessed fracture methods through interpretive analyses of 6 large-scale fracture experiments in reactor pressure vessel (RPV) steels under pressurized- thermal-shock (PTS) loading. In FALSIRE II, experiments examined cleavage fracture in RPV steels for a wide range of materials, crack geometries, and constraint and loading conditions. The cracks were relatively shallow, in the transition temperature region. Included were cracks showing either unstable extension or two stages of extensions under transient thermal and mechanical loads. Crack initiation was also investigated in connection with clad surfaces and with biaxial load. Within FALSIRE II, comparative assessments were performed for 7 reference fracture experiments based on 45 analyses received from 22 organizations representing 12 countries. Temperature distributions in thermal shock loaded samples were approximated with high accuracy and small scatter bands. Structural response was predicted reasonably well; discrepancies could usually be traced to the assumed material models and approximated material properties. Almost all participants elected to use the finite element method.

  14. CSNI Project for Fracture Analyses of Large-Scale International Reference Experiments (FALSIRE II)

    International Nuclear Information System (INIS)

    Bass, B.R.; Pugh, C.E.; Keeney, J.; Schulz, H.; Sievers, J.

    1996-11-01

    A summary of Phase II of the Project for FALSIRE is presented. FALSIRE was created by the Fracture Assessment Group (FAG) of the OECD/NEA's Committee on the Safety of Nuclear Installations (CNSI) Principal Working Group No. 3. FALSIRE I in 1988 assessed fracture methods through interpretive analyses of 6 large-scale fracture experiments in reactor pressure vessel (RPV) steels under pressurized- thermal-shock (PTS) loading. In FALSIRE II, experiments examined cleavage fracture in RPV steels for a wide range of materials, crack geometries, and constraint and loading conditions. The cracks were relatively shallow, in the transition temperature region. Included were cracks showing either unstable extension or two stages of extensions under transient thermal and mechanical loads. Crack initiation was also investigated in connection with clad surfaces and with biaxial load. Within FALSIRE II, comparative assessments were performed for 7 reference fracture experiments based on 45 analyses received from 22 organizations representing 12 countries. Temperature distributions in thermal shock loaded samples were approximated with high accuracy and small scatter bands. Structural response was predicted reasonably well; discrepancies could usually be traced to the assumed material models and approximated material properties. Almost all participants elected to use the finite element method

  15. Floristic Inventory of The Proposed Site for Tarsier Tourism Center in Villa Aurora, Bilar, Bohol, Philippines

    Directory of Open Access Journals (Sweden)

    Tomas D Reyes Jr

    2015-07-01

    Full Text Available The study assessed the present vegetation composition of the Proposed Site for the Tarsier Tourism Center (PTTC at Villa Aurora, Bilar, Bohol and performed a comparative analysis with the existing Tarsier Sanctuary (TS at Canapnapan, Corella, Bohol. The basis for comparison was the computed importance values, species richness, species dominance, and percent distribution of plants according to self-defined DBH classes. Results showed that both sites had very high species richness and evenness values. Common overstorey and understorey plant species found in both areas were katagpo (Psychotria sp., sagimsim (Syzygium brevistylum [C. B. Rob]Merr. and bagauak (Clerodendrum minahassae Teijsm. & Binn.. Apart from sagimsim (Syzygium brevistylum [C.B.Rob.] Merr., selaginella (Selaginella cuppresina Lin., and lunas (Lunasia amara Blanco were also common in the ground vegetation of both areas. Percent distribution of trees according to self-defined DBH classes revealed that PTTC had 87.55% of the total recorded plants with DBH measurements of 20 cm. Percent distribution of trees on these DBH ranges (especially on DBH class >20 cm indicated the presence of medium and large trees. The largest DBH measured in the PTTC was 70 cm while in TS was only 22 cm. The proposed 10-ha site in Villa Aurora, Bilar, is suited to be utilized as Tarsier Tourism Center. In case the proposed project is to be pursued, enclosure similar to what has been constructed in Canapnapan, Corella, Bohol, Philippines should also be established to prevent stray animals from predating the captive tarsiers.

  16. OC5 Project Phase II: Validation of Global Loads of the DeepCwind Floating Semisubmersible Wind Turbine

    DEFF Research Database (Denmark)

    Robertson, Amy N.; Wendt, Fabian; Jonkman, Jason M.

    2017-01-01

    This paper summarizes the findings from Phase II of the Offshore Code Comparison, Collaboration, Continued, with Correlation project. The project is run under the International Energy Agency Wind Research Task 30, and is focused on validating the tools used for modeling offshore wind systems thro...

  17. National Centers for Environmental Prediction-Department of Energy (NCEP-DOE) Atmospheric Model Intercomparison Project (AMIP)-II Reanalysis (Reanalysis-2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NCEP-DOE Atmospheric Model Intercomparison Project (AMIP-II) reanalysis is a follow-on project to the "50-year" (1948-present) NCEP-NCAR Reanalysis Project....

  18. IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer

    International Nuclear Information System (INIS)

    Yin, Ning; Shi, Ji; Wang, Dapeng; Tong, Tong; Wang, Mingrong; Fan, Feiyue; Zhan, Qimin

    2012-01-01

    Highlights: ► IQGAP1 interacts with Aurora-A through its RGCt domain. ► Overexpression of IQGAP1 prevents ubiquitination of Aurora-A. ► Overexpression of IQGAP1 enhances the protein stability of Aurora-A. ► Overexpression of IQGAP1 promotes the kinase activity of Aurora-A. -- Abstract: IQGAP1, a ubiquitously expressed scaffold protein, has been identified in a wide range of organisms. It participates in multiple aspects of cellular events by binding to and regulating numerous interacting proteins. In our present study, we identified a new IQGAP1 binding protein named Aurora-A which is an oncogenic protein and overexpressed in various types of human tumors. In vitro analysis with GST-Aurora-A fusion proteins showed a physical interaction between Aurora-A and IQGAP1. Moreover, the binding also occurred in HeLa cells as endogenous Aurora-A co-immunoprecipitated with IQGAP1 from the cell lysates. Overexpression of IQGAP1 resulted in an elevation of both expression and activity of Aurora-A kinase. Endogenous IQGAP1 knockdown by siRNA promoted Aurora-A degradation whereas IQGAP1 overexpression enhanced the stability of Aurora-A. Additionally, we documented that the IQGAP1-induced cell proliferation was suppressed by knocking down Aurora-A expression. Taken together, our results showed an unidentified relationship between Aurora-A and IQGAP1, and provided a new insight into the molecular mechanism by which IQGAP1 played a regulatory role in cancer.

  19. Preliminary Conceptual Design Report for the FACET-II Project at SLAC National Accelerator Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Hogan, Mark [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2016-04-22

    Plasma wakefield acceleration has the potential to dramatically shrink the size and cost of particle accelerators. Research at the SLAC National Accelerator Laboratory has demonstrated that plasmas can provide 1,000 times the acceleration in a given distance compared with current technologies. Developing revolutionary and more efficient acceleration techniques that allow for an affordable high-energy collider is the focus of FACET, a National User Facility at SLAC. The existing FACET National User Facility uses part of SLAC’s two-mile-long linear accelerator to generate high-density beams of electrons and positrons. FACET-II is a new test facility to develop advanced acceleration and coherent radiation techniques with high-energy electron and positron beams. It is the only facility in the world with high energy positron beams. FACET-II provides a major upgrade over current FACET capabilities and the breadth of the potential research program makes it truly unique. It will synergistically pursue accelerator science that is vital to the future of both advanced acceleration techniques for High Energy Physics, ultra-high brightness beams for Basic Energy Science, and novel radiation sources for a wide variety of applications. The design parameters for FACET-II are set by the requirements of the plasma wakefield experimental program. To drive the plasma wakefield requires a high peak current, in excess of 10kA. To reach this peak current, the electron and positron design bunch size is 10μ by 10μ transversely with a bunch length of 10μ. This is more than 200 times better than what has been achieved at the existing FACET. The beam energy is 10 GeV, set by the Linac length available and the repetition rate is up to 30 Hz. The FACET-II project is scheduled to be constructed in three major stages. Components of the project discussed in detail include the following: electron injector, bunch compressors and linac, the positron system, the Sector 20 sailboat and W chicanes

  20. Proposed Tenaska Washington II Generation Project : Final Environmental Impact Statement. Volume 2: Public Involvement.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1994-01-01

    In regard to the proposed Tenaska Washington II Generation Project, the goal of the Bonneville Power Administration`s (BPA) Environmental Impact Statement (EIS) public involvement process is to determine the issues to be examined and pertinent analyses to be conducted and to solicit comments on the content and quality of information presented in the Draft Environmental Impact Statement (DEIS). Comments and questions are solicited from the public and government agencies during the scoping process and during the comment period and public hearing on the DEIS, to find out what is of most concern to them. The end product of the public involvement process is the Comment Report which follows in part of this volume on Public Involvement.

  1. Aurora-A regulates MCRS1 function during mitosis.

    Science.gov (United States)

    Meunier, Sylvain; Timón, Krystal; Vernos, Isabelle

    2016-07-02

    The mitotic spindle is made of microtubules (MTs) nucleated through different pathways involving the centrosomes, the chromosomes or the walls of pre-existing MTs. MCRS1 is a RanGTP target that specifically associates with the chromosome-driven MTs protecting them from MT depolymerases. MCRS1 is also needed for the control of kinetochore fiber (K-fiber) MT minus-ends dynamics in metaphase. Here, we investigated the regulation of MCRS1 activity in M-phase. We show that MCRS1 is phosphorylated by the Aurora-A kinase in mitosis on Ser35/36. Although this phosphorylation has no role on MCRS1 localization to chromosomal MTs and K-fiber minus-ends, we show that it regulates MCRS1 activity in mitosis. We conclude that Aurora-A activity is particularly important in the tuning of K-fiber minus-ends dynamics in mitosis.

  2. Identification of clouds and aurorae in optical data images

    CERN Document Server

    Seviour, R; Honary, F

    2003-01-01

    In this paper we present an automatic image recognition technique used to identify clouds and aurorae in digital images, taken with a CCD all-sky imager. The image recognition algorithm uses image segmentation to generate a binary block object image. Object analysis is then performed on the binary block image, the results of which are used to assess whether clouds, aurorae and stars are present in the original image. The need for such an algorithm arises because the optical study of particle precipitation into the Earth's atmosphere by the Ionosphere and Radio Propagation Group at Lancaster generates vast data-sets, over 25 000 images/year, making manual classification of all the images impractical.

  3. Aurorae. Firework in the sky. 2. upd. ed.; Polarlichter. Feuerwerk am Himmel

    Energy Technology Data Exchange (ETDEWEB)

    Pfoser, Andreas; Eklund, Tom

    2013-07-01

    Aurorae are fascinating phenomena. As aurora borealis and aurora australis occurring in the polar regions of both earth hemispheres, their incessant color and shape games put people in wonder. The meteorologist Andreas Pfoser explains the physical connections, which lead to the formation of this natural phenomenon. The link with the activity of the sun and the interaction in the earth atmosphere are explained detailedly and understandably. The fantastic recordings, presented in generous horizontal format has collected the Finnish aurora photographer Tom Eklund over a period of time of 14 years. Thereby it succeeded, to document also some events, the origin of which on our daystar were recorded by solar satellites, so that the sequence of events from the solar eruption until the aurora spectacle can be reproduced. The present 2nd edition contains new scientific findings. Additionally numerous aurora pictures were replaced by more actual photos created with modern technology.

  4. Planetary protection in the framework of the Aurora exploration program

    Science.gov (United States)

    Kminek, G.

    The Aurora Exploration Program will give ESA new responsibilities in the field of planetary protection. Until now, ESA had only limited exposure to planetary protection from its own missions. With the proposed ExoMars and MSR missions, however, ESA will enter the realm of the highest planetary protection categories. As a consequence, the Aurora Exploration Program has initiated a number of activities in the field of planetary protection. The first and most important step was to establish a Planetary Protection Working Group (PPWG) that is advising the Exploration Program Advisory Committee (EPAC) on all matters concerning planetary protection. The main task of the PPWG is to provide recommendations regarding: Planetary protection for robotic missions to Mars; Planetary protection for a potential human mission to Mars; Review/evaluate standards & procedures for planetary protection; Identify research needs in the field of planetary protection. As a result of the PPWG deliberations, a number of activities have been initiated: Evaluation of the Microbial Diversity in SC Facilities; Working paper on legal issues of planetary protection and astrobiology; Feasibility study on a Mars Sample Return Containment Facility; Research activities on sterilization procedures; Training course on planetary protection (May, 2004); Workshop on sterilization techniques (fall 2004). In parallel to the PPWG, the Aurora Exploration Program has established an Ethical Working Group (EWG). This working group will address ethical issues related to astrobiology, planetary protection, and manned interplanetary missions. The recommendations of the working groups and the results of the R&D activities form the basis for defining planetary protection specification for Aurora mission studies, and for proposing modification and new inputs to the COSPAR planetary protection policy. Close cooperation and free exchange of relevant information with the NASA planetary protection program is strongly

  5. Measurement of the electrostatic field in aurora by antarctic rocket

    International Nuclear Information System (INIS)

    Takeya, Yoshio; Minami, Shigeyuki

    1974-01-01

    The direct measurement of the electrostatic field produced by the flow of charged particles and geomagnetic field in aurora has been carried out by means of rockets or satellites. The construction of an electric field meter and its characteristics are described, which measures the vectors of electric field with antarctic rockets. New scheme is presented: three components of an electric field are directly obtained through the probes set in three directions. (Mori, K.)

  6. Dynamics of Auroras Conjugate to the Dayside Reconnection Region.

    Science.gov (United States)

    Mende, S. B.; Frey, H. U.; Doolittle, J. H.

    2006-12-01

    During periods of northward IMF Bz, observations of the IMAGE satellite FUV instrument demonstrated the existence of an auroral footprint of the dayside lobe reconnection region. Under these conditions the dayside "reconnection spot" is a distinct feature being separated from the dayside auroral oval. In the IMAGE data, ~100 km spatial and 2 minutes temporal resolution, this feature appeared as a modest size, 200 to 500 km in diameter, diffuse spot which was present steadily while the IMF conditions lasted and the solar wind particle pressure was large enough to create a detectable signature. Based on this evidence, dayside reconnection observed with this resolution appears to be a steady state process. There have been several attempts to identify and study the "reconnection foot print aurora" with higher resolution from the ground. South Pole Station and the network of the US Automatic Geophysical Observatories (AGO-s) in Antarctica have all sky imagers that monitor the latitude region of interest (70 to 85 degrees geomagnetic) near midday during the Antarctic winter. In this paper we present sequences of auroral images that were taken during different conditions of Bz and therefore they are high spatial resolution detailed views of the auroras associated with reconnection. During negative Bz, auroras appear to be dynamic with poleward moving auroral forms that are clearly observed by ground based imagers with a ~few km spatial resolution. During positive Bz however the extremely high latitude aurora is much more stable and shows no preferential meridional motions. It should be noted that winter solstice conditions, needed for ground based observations, produce a dipole tilt in which reconnection is not expected to be symmetric and the auroral signatures might favor the opposite hemisphere.

  7. Control system for compact SR light source 'AURORA'

    International Nuclear Information System (INIS)

    Fukami, Nobutaka; Kariya, Hiroyuki; Yamada, Hironari

    1991-01-01

    The computer control system developed for 'AURORA' has a three level hierarchical architecture. The top level is Central Intelligence System (CIS), and the second one is Autonomic Control System (ACS). The bottom one is an assembly of distributed local controllers linked to the ACS level through optical fibers. This system provides fully automated operation, and a powerful machine study capability through the associated man-machine console and an interpretive operation language. (author)

  8. Performance of the Aurora KrF ICF laser system

    International Nuclear Information System (INIS)

    Jones, J.E.; Czuchlewski, S.J.; Turner, T.P.; Watt, R.G.; Thomas, S.J.; Netz, D.A.; Tallman, C.R.; Mack, J.M.; Figueira, J.F.

    1990-01-01

    Because short wavelength lasers are attractive for inertial confinement fusion (ICF), the Department of Energy is sponsoring work at Los Alamos National Laboratory in krypton-fluoride (KrF) laser technology. Aurora is a short-pulse, high-power, KrF laser system. It serves as an end-to-end technology demonstration prototype for large-scale ultraviolet laser systems for short wavelength ICF research. The system employs optical angular multiplexing and serial amplification by electron-beam-driven KrF laser amplifiers. The 1 to 5 ns pulse of the Aurora front end is split into 96 beams which are angularly and temporally multiplexed to produce a 480 ns pulse train for amplification by four KrF laser amplifiers. In the present system configuration half (48) of the amplified pulses are demultiplexed using different optical path lengths and delivered simultaneously to target. This paper discusses how the Aurora laser system has entered the initial operational phase by delivering pulse energies of greater than one kilojoule to target

  9. The Discovery of Aurora Kinase Inhibitor by Multi-Docking-Based Virtual Screening

    Directory of Open Access Journals (Sweden)

    Jun-Tae Kim

    2014-11-01

    Full Text Available We report the discovery of aurora kinase inhibitor using the fragment-based virtual screening by multi-docking strategy. Among a number of fragments collected from eMololecules, we found four fragment molecules showing potent activity (>50% at 100 μM against aurora kinase. Based on the explored fragment scaffold, we selected two compounds in our synthesized library and validated the biological activity against Aurora kinase.

  10. Materials information for science and technology (MIST): Project overview: Phases I and II and general considerations

    Energy Technology Data Exchange (ETDEWEB)

    Grattidge, W.; Westbrook, J.; McCarthy, J.; Northrup, C. Jr.; Rumble, J. Jr.

    1986-01-01

    This report documents the initial phases of the Materials Information for Science and Technology (MIST) project jointly supported by the Department of Energy and the National Bureau of Standards. The purpose of MIST is to demonstrate the power and utility of computer access to materials property data. The initial goals include: to exercise the concept of a computer network of materials databases and to build a demonstration of such a system suitable for use as the core of operational systems in the future. Phases I and II are described in detail herein. In addition, a discussion is given of the expected usage of the system. The primary MIST prototype project is running on an IBM 3084 under STS at the Stanford University's Information Technology Services (ITS). Users can access the Stanford system via ARPANET, TELENET, and TYMNET, as well as via commercial telephone lines. For fastest response time and use of the full screen PRISM interface, direct connection using a 2400 baud modem with the MNP error-correcting protocol over standard telephone lines gives the best results - though slower speed connections and a line-oriented interface are also available. This report gives detailed plans regarding the properties to be enterend and the materials to be entered into the system.

  11. Phase II Water Rental Pilot Project: Snake River Resident Fish and Wildlife Resources and Management Recommendations.

    Energy Technology Data Exchange (ETDEWEB)

    Stovall, Stacey H.

    1994-08-01

    The Idaho Water Rental Pilot Project was implemented in 1991 as part of the Non-Treaty Storage Fish and Wildlife Agreement between Bonneville Power Administration and the Columbia Basin Fish and Wildlife Authority. The goal of the project is to quantify resident fish and wildlife impacts resulting from salmon flow augmentation releases made from the upper Snake River Basin. Phase I summarized existing resource information and provided management recommendations to protect and enhance resident fish and wildlife habitat resulting from storage releases for the I improvement of an adromous fish migration. Phase II includes the following: (1) a summary of recent biological, legal, and political developments within the basin as they relate to water management issues, (2) a biological appraisal of the Snake River between American Falls Reservoir and the city of Blackfoot to examine the effects of flow fluctuation on fish and wildlife habitat, and (3) a preliminary accounting of 1993--1994 flow augmentation releases out of the upper Snake, Boise, and Payette river systems. Phase III will include the development of a model in which annual flow requests and resident fish and wildlife suitability information are interfaced with habitat time series analysis to provide an estimate of resident fish and wildlife resources.

  12. Plant Aurora kinases play a role in maintenance of primary meristems and control of endoreduplication

    Czech Academy of Sciences Publication Activity Database

    Petrovská, Beáta; Cenklová, Věra; Pochylová, Žaneta; Kourová, Hana; Doskočilová, Anna; Plíhal, Ondřej; Binarová, Lenka; Binarová, Pavla

    2012-01-01

    Roč. 193, č. 3 (2012), s. 590-604 ISSN 0028-646X R&D Projects: GA ČR(CZ) GA204/07/1169; GA ČR GP204/09/P155; GA ČR(CZ) GD204/09/H084; GA MŠk(CZ) LC06034; GA MŠk LC545; GA AV ČR IAA500200719 Grant - others:GA MŠk(CZ) ED0007/01/01 Program:ED Institutional research plan: CEZ:AV0Z50380511; CEZ:AV0Z50200510 Keywords : Arabidopsis thaliana * AtTPX2 (targeting protein for Xklp2) * Aurora kinases Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 6.736, year: 2012

  13. The PEP-II/BaBar Project-Wide Database using World Wide Web and Oracle*Case

    International Nuclear Information System (INIS)

    Chan, A.; Crane, G.; MacGregor, I.; Meyer, S.

    1995-12-01

    The PEP-II/BaBar Project Database is a tool for monitoring the technical and documentation aspects of the accelerator and detector construction. It holds the PEP-II/BaBar design specifications, fabrication and installation data in one integrated system. Key pieces of the database include the machine parameter list, components fabrication and calibration data, survey and alignment data, property control, CAD drawings, publications and documentation. This central Oracle database on a UNIX server is built using Oracle*Case tools. Users at the collaborating laboratories mainly access the data using World Wide Web (WWW). The Project Database is being extended to link to legacy databases required for the operations phase

  14. Inclined Zenith Aurora over Kyoto on 17 September 1770: Graphical Evidence of Extreme Magnetic Storm

    Science.gov (United States)

    Kataoka, Ryuho; Iwahashi, Kiyomi

    2017-10-01

    Red auroras were observed in Japan during an extreme magnetic storm that occurred on 17 September 1770. We show new evidence that the red aurora extended toward the zenith of Kyoto around midnight. The basic appearance of the historical painting of the red aurora is geometrically reproduced based on the inclination of the local magnetic field and a detailed description in a newly discovered diary. The presence of the inclined zenith aurora over Kyoto suggests that the intensity of the September 1770 magnetic storm is comparable to, or slightly larger than that of the September 1859 Carrington storm.

  15. Ancient writings reveal presence of aurora in 13th-century Canadian Arctic

    Science.gov (United States)

    Silverman, Sam

    Modern Norway, Iceland, and Greenland are subject to frequent displays of the aurora borealis. The aurora can be viewed on almost every clear night in the northern part of Iceland and southern Greenland, which lie in or near the auroral oval. Thus, it is surprising to find almost no mention of the aurora in medieval Norse chronicles or in the extensive Icelandic saga literature. Only one paragraph, in the "King's Mirror," a Norwegian writing dating to about 1250 C.E., notes the occurrence of the aurora in Greenland. The author reports this as hearsay and not from personal knowledge. For a fuller discussion of the Norse literature, see Brekke and Egeland [1983].

  16. Evolutionary relationships of Aurora kinases: Implications for model organism studies and the development of anti-cancer drugs

    Directory of Open Access Journals (Sweden)

    Patrick Denis R

    2004-10-01

    Full Text Available Abstract Background As key regulators of mitotic chromosome segregation, the Aurora family of serine/threonine kinases play an important role in cell division. Abnormalities in Aurora kinases have been strongly linked with cancer, which has lead to the recent development of new classes of anti-cancer drugs that specifically target the ATP-binding domain of these kinases. From an evolutionary perspective, the species distribution of the Aurora kinase family is complex. Mammals uniquely have three Aurora kinases, Aurora-A, Aurora-B, and Aurora-C, while for other metazoans, including the frog, fruitfly and nematode, only Aurora-A and Aurora-B kinases are known. The fungi have a single Aurora-like homolog. Based on the tacit assumption of orthology to human counterparts, model organism studies have been central to the functional characterization of Aurora kinases. However, the ortholog and paralog relationships of these kinases across various species have not been rigorously examined. Here, we present comprehensive evolutionary analyses of the Aurora kinase family. Results Phylogenetic trees suggest that all three vertebrate Auroras evolved from a single urochordate ancestor. Specifically, Aurora-A is an orthologous lineage in cold-blooded vertebrates and mammals, while structurally similar Aurora-B and Aurora-C evolved more recently in mammals from a duplication of an ancestral Aurora-B/C gene found in cold-blooded vertebrates. All so-called Aurora-A and Aurora-B kinases of non-chordates are ancestral to the clade of chordate Auroras and, therefore, are not strictly orthologous to vertebrate counterparts. Comparisons of human Aurora-B and Aurora-C sequences to the resolved 3D structure of human Aurora-A lends further support to the evolutionary scenario that vertebrate Aurora-B and Aurora-C are closely related paralogs. Of the 26 residues lining the ATP-binding active site, only three were variant and all were specific to Aurora-A. Conclusions In

  17. AURORA on MEGSAT 1 a photon counting observatory for the Earth UV night-sky background and Aurora emission

    CERN Document Server

    Monfardini, A; Stalio, R; Mahne, N; Battiston, R; Menichelli, M; Mazzinghi, P

    2001-01-01

    A low-mass, low-cost photon-counting scientific payload has been developed and launched on a commercial microsatellite in order to study the near-UV night-sky background emission with a telescope nicknamed 'Notte' and the Aurora emission with 'Alba'. AURORA, this is the name of the experiment, will determine, with the 'Notte' channel, the overall night-side photon background in the 300-400 nm spectral range, together with a particular 2 sup + N sub 2 line (lambda sub c =337 nm). The 'Alba' channel, on the other hand, will study the Aurora emissions in four different spectral bands (FWHM=8.4-9.6 nm) centered on: 367 nm (continuum evaluation), 391 nm (1 sup - N sup + sub 2), 535 nm (continuum evaluation), 560 nm (OI). The instrument has been launched on the 26 September, 2000 from the Baikonur cosmodrome on a modified SS18 Dnepr-1 'Satan' rocket. The satellite orbit is nearly circular (h sub a sub p sub o sub g sub e sub e =648 km, e=0.0022), and the inclination of the orbital plane is 64.56 deg. An overview of...

  18. AURORA on MEGSAT 1: a photon counting observatory for the Earth UV night-sky background and Aurora emission

    International Nuclear Information System (INIS)

    Monfardini, A.; Trampus, P.; Stalio, R.; Mahne, N.; Battiston, R.; Menichelli, M.; Mazzinghi, P.

    2001-01-01

    A low-mass, low-cost photon-counting scientific payload has been developed and launched on a commercial microsatellite in order to study the near-UV night-sky background emission with a telescope nicknamed 'Notte' and the Aurora emission with 'Alba'. AURORA, this is the name of the experiment, will determine, with the 'Notte' channel, the overall night-side photon background in the 300-400 nm spectral range, together with a particular 2 + N 2 line (λ c =337 nm). The 'Alba' channel, on the other hand, will study the Aurora emissions in four different spectral bands (FWHM=8.4-9.6 nm) centered on: 367 nm (continuum evaluation), 391 nm (1 - N + 2 ), 535 nm (continuum evaluation), 560 nm (OI). The instrument has been launched on the 26 September, 2000 from the Baikonur cosmodrome on a modified SS18 Dnepr-1 'Satan' rocket. The satellite orbit is nearly circular (h apogee =648 km, e=0.0022), and the inclination of the orbital plane is 64.56 deg. An overview of the techniques adopted is given in this paper

  19. Aurora-A overexpression and aneuploidy predict poor outcome in serous ovarian carcinoma.

    Science.gov (United States)

    Lassus, Heini; Staff, Synnöve; Leminen, Arto; Isola, Jorma; Butzow, Ralf

    2011-01-01

    Aurora-A is a potential oncogene and therapeutic target in ovarian carcinoma. It is involved in mitotic events and overexpression leads to centrosome amplification and chromosomal instability. The objective of this study was to evaluate the clinical significance of Aurora-A and DNA ploidy in serous ovarian carcinoma. Serous ovarian carcinomas were analysed for Aurora-A protein by immunohistochemistry (n=592), Aurora-A copy number by CISH (n=169), Aurora-A mRNA by real-time PCR (n=158) and DNA ploidy by flowcytometry (n=440). Overexpression of Aurora-A was found in 27% of the tumors, cytoplasmic overexpression in 11% and nuclear in 17%. The cytoplasmic and nuclear overexpression were nearly mutually exclusive. Both cytoplasmic and nuclear overexpression were associated with shorter survival, high grade, high proliferation index and aberrant p53. Interestingly, only cytoplasmic expression was associated with aneuploidy and expression of phosphorylated Aurora-A. DNA ploidy was associated with poor patient outcome as well as aggressive clinicopathological parameters. In multivariate analysis, Aurora-A overexpression appeared as an independent prognostic factor for disease-free survival, together with grade, stage and ploidy. Aurora-A protein expression is strongly linked with poor patient outcome and aggressive disease characteristics, which makes Aurora-A a promising biomarker and a potential therapeutic target in ovarian carcinoma. Cytoplasmic and nuclear Aurora-A protein may have different functions. DNA aneuploidy is a strong predictor of poor prognosis in serous ovarian carcinoma. Copyright © 2010 Elsevier Inc. All rights reserved.

  20. The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress.

    Science.gov (United States)

    Amaral, Nuno; Vendrell, Alexandre; Funaya, Charlotta; Idrissi, Fatima-Zahra; Maier, Michael; Kumar, Arun; Neurohr, Gabriel; Colomina, Neus; Torres-Rosell, Jordi; Geli, María-Isabel; Mendoza, Manuel

    2016-05-01

    Anaphase chromatin bridges can lead to chromosome breakage if not properly resolved before completion of cytokinesis. The NoCut checkpoint, which depends on Aurora B at the spindle midzone, delays abscission in response to chromosome segregation defects in yeast and animal cells. How chromatin bridges are detected, and whether abscission inhibition prevents their damage, remain key unresolved questions. We find that bridges induced by DNA replication stress and by condensation or decatenation defects, but not dicentric chromosomes, delay abscission in a NoCut-dependent manner. Decatenation and condensation defects lead to spindle stabilization during cytokinesis, allowing bridge detection by Aurora B. NoCut does not prevent DNA damage following condensin or topoisomerase II inactivation; however, it protects anaphase bridges and promotes cellular viability after replication stress. Therefore, the molecular origin of chromatin bridges is critical for activation of NoCut, which plays a key role in the maintenance of genome stability after replicative stress.

  1. Self-reliance and innovation of Qinshan phase II NPP project

    International Nuclear Information System (INIS)

    Ye Qizhen; Yang Lanhe

    2007-01-01

    This article mainly describes the self-reliance and innovation of Qinshan nuclear power project of phase II, in-between it contains new reactor core design, as well as related experimental and calculation analysis, especially for new reactor design produced fluid-induced vibration model test, theoretical analysis and testing in-built reactor; aiming at two-loop NSSS a series improvement made for safety systems and related safety analysis to enhance their reliability and redundancy; according to specialty of two-loop NSSS an optimization made for NPP parameters and design of related equipments, for the purpose to make the output of NPP maximal; design of main reactor building and T-G building also improved according to characteristics of two-loop NSSS and site conditions. CRDM and refueling machine are researched and manufactured on base of self-reliance, their performance are better than design requirements, large portion of key equipments are localized through different way. In construction first time realized the integrated erection of containment dome. During the commissioning non-nuclear steam driving of T-G set, as well as 500 kV high voltage rising using emergent diesel generator, etc. are carried out.In period of operation still continuous innovation and improvement are made, so that to keep the good record of operation. (authors)

  2. Cultural-resource survey report: Hoover Dam Powerplant Modification Project II. Associated transmission-line facility

    International Nuclear Information System (INIS)

    Queen, R.L.

    1991-06-01

    The Bureau of Reclamation (Reclamation) is proposing to modify or install additional transmission facilities between the Hoover Dam hydroelectric plant and the Western Area Power Authority substation near Boulder City, Nevada. Reclamation has completed cultural resource investigations to identify historic or prehistoric resources in the project area that might be affected during construction of the transmission line. Four possible transmission corridors approximately 50 feet wide and between 9.5 and 11.5 miles long were investigated. The proposed transmission lines either parallel or replace existing transmission lines. The corridors generally have undergone significant disturbance from past transmission line construction. A Class II sampling survey covering approximately 242 acres was conducted. Access or construction roads have not been identified and surveys of these areas will have to be completed in the future. No historic or prehistoric archeological sites were encountered within the four corridor right-of-ways. It is believed that the probability for prehistoric sites is very low. Four historic period sites were recorded that are outside, but near, the proposed corridor. These sites are not individually eligible for the National Register of Historic Places, but may be associated with the construction of Hoover Dam and contribute to a historic district or multiple property resource area focusing on the dam and its construction

  3. Project management of the build of the shore test facility for the prototype of PWR II

    International Nuclear Information System (INIS)

    Clarkson, D.T.

    1987-01-01

    The PWR II is a new design of nuclear steam raising plant for the Royal Navy's submarines. It features improved engineering for safety, increased power, increased shock resistance, reduced noise transmission to sea and reduced manning requirement. It is to be tested in a new prototype testing facility, the Shore Test Facility, which is a section of submarine hull containing a prototype of the nuclear steam raising plant and its support system. It is installed at the Vulcan Naval Reactor Test establishment at Dounreay in Scotland. The function of the establishment is to test new designs of core and reactor plant, validate the mathematical models used in their design, develop improved methods of operation and maintenance of the plant and test new items of equipment. The Shore Test Facility was built in large sections at Barrow-in-Furness and transported to Scotland. The project management for the construction of the Shore Test Facility is explained. It involves personnel from the Royal Navy, and a large number of people working for the contractors involved in the buildings, transportation, operation and maintenance of the Facility. (U.K.)

  4. AIDS incidence and mortality in injecting drug users: the AjUDE-Brasil II Project

    Directory of Open Access Journals (Sweden)

    Cardoso Mauro Nogueira

    2006-01-01

    Full Text Available This paper presents AIDS incidence and mortality among injecting drug users (IDUs reached by the AjUDE-Brasil II Project. From a cross-sectional survey, 478 IDUs were interviewed in three Brazilian cities: Porto Alegre, São José do Rio Preto, and Itajaí. The cohort was followed up in the Brazilian surveillance database for AIDS and mortality during 2000 and 2001. AIDS incidence was 1.1 cases per 100 person-years, and the mortality rate was 2.8 deaths per 100 person-years. AIDS cases only occurred in IDUs who reported ever having shared injecting equipment. Female gender (RR = 5.30, homelessness (RR = 6.16, and report of previous sexual relations with same-sex partners (RR = 6.21 were associated with AIDS. Deaths occurred only among males. Homelessness (RR = 3.00, lack of income (RR = 2.65, HIV seropositive status (RR = 4.52, and no history of incarceration (RR = 3.71 were also associated with death. These findings support evidence that gender and socioeconomic conditions are both determinants of morbidity and mortality in Brazilian IDUs.

  5. Thermal-Mechanical Study of 3.9 GHz CW Coupler and Cavity for LCLS-II Project

    Energy Technology Data Exchange (ETDEWEB)

    Gonin, Ivan [Fermilab; Harms, Elvin [Fermilab; Khabiboulline, Timergali [Fermilab; Solyak, Nikolay [Fermilab; Yakovlev, Vyacheslav [Fermilab

    2017-05-01

    Third harmonic system was originally developed by Fermilab for FLASH facility at DESY and then was adopted and modified by INFN for the XFEL project [1-3]. In contrast to XFEL project, all cryomodules in LCLS-II project will operate in CW regime with higher RF average power for 1.3 GHz and 3.9 GHz cavities and couplers. Design of the cavity and fundamental power coupler has been modified to satisfy LCLS-II requirements. In this paper we discuss the results of COMSOL thermal and mechanical analysis of the 3.9 GHz coupler and cavity to verify proposed modifica-tion of the design. For the dressed cavity we present simulations of Lorentz force detuning, helium pressure sensitivity df/dP and major mechanical resonances.

  6. Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process.

    Science.gov (United States)

    Lordier, Larissa; Chang, Yunhua; Jalil, Abdelali; Aurade, Frédéric; Garçon, Loïc; Lécluse, Yann; Larbret, Frédéric; Kawashima, Toshiyuki; Kitamura, Toshio; Larghero, Jérôme; Debili, Najet; Vainchenker, William

    2010-09-30

    Polyploidization of megakaryocytes (MKs), the platelet precursors, occurs by endomitosis, a mitotic process that fails at late stages of cytokinesis. Expression and function of Aurora B kinase during endomitosis remain controversial. Here, we report that Aurora B is normally expressed during the human MK endomitotic process. Aurora B localized normally in the midzone or midbody during anaphase and telophase in low ploidy megakaryocytes and in up to 16N rare endomitotic MKs was observed. Aurora B was also functional during cytokinesis as attested by phosphorylation of both its activation site and MgcRacGAP, its main substrate. However, despite its activation, Aurora B did not prevent furrow regression. Inhibition of Aurora B by AZD1152-HQPA decreased cell cycle entry both in 2N to 4N and polyploid MKs and induced apoptosis mainly in 2N to 4N cells. In both MK classes, AZD1152-HQPA induced p53 activation and retinoblastoma hypophosphorylation. Resistance of polyploid MKs to apoptosis correlated to a high BclxL level. Aurora B inhibition did not impair MK polyploidization but profoundly modified the endomitotic process by inducing a mis-segregation of chromosomes and a mitotic failure in anaphase. This indicates that Aurora B is dispensable for MK polyploidization but is necessary to achieve a normal endomitotic process.

  7. Bora and Aurora-A continue to activate Plk1 in mitosis.

    Science.gov (United States)

    Bruinsma, Wytse; Macurek, Libor; Freire, Raimundo; Lindqvist, Arne; Medema, René H

    2014-02-15

    Polo-like kinase-1 (Plk1) is required for proper cell division. Activation of Plk1 requires phosphorylation on a conserved threonine in the T-loop of the kinase domain (T210). Plk1 is first phosphorylated on T210 in G2 phase by the kinase Aurora-A, in concert with its cofactor Bora. However, Bora was shown to be degraded prior to entry into mitosis, and it is currently unclear how Plk1 activity is sustained in mitosis. Here we show that the Bora-Aurora-A complex remains the major activator of Plk1 in mitosis. We show that a small amount of Aurora-A activity is sufficient to phosphorylate and activate Plk1 in mitosis. In addition, a fraction of Bora is retained in mitosis, which is essential for continued Aurora-A-dependent T210 phosphorylation of Plk1. We find that once Plk1 is activated, minimal amounts of the Bora-Aurora-A complex are sufficient to sustain Plk1 activity. Thus, the activation of Plk1 by Aurora-A may function as a bistable switch; highly sensitive to inhibition of Aurora-A in its initial activation, but refractory to fluctuations in Aurora-A activity once Plk1 is fully activated. This provides a cell with robust Plk1 activity once it has committed to mitosis.

  8. Akt Inhibitor A-443654 Interferes with Mitotic Progression by Regulating Aurora A Kinase Expression

    Directory of Open Access Journals (Sweden)

    Xuesong Liu

    2008-08-01

    Full Text Available Both Akt and Aurora A kinase have been shown to be important targets for intervention for cancer therapy. We report here that Compound A (A-443654, a specific Akt inhibitor, interferes with mitotic progression and bipolar spindle formation. Compound A induces G2/M accumulation, defects in centrosome separation, and formation of either monopolar arrays or disorganized spindles. On the basis of gene expression array studies, we identified Aurora A as one of the genes regulated transcriptionally by Akt inhibitors including Compound A. Inhibition of the phosphatidylinositol 3-kinase (PI3K/Akt pathway, either by PI3K inhibitor LY294002 or by Compound A, dramatically inhibits the promoter activity of Aurora A, whereas the mammalian target of rapamycin inhibitor has little effect, suggesting that Akt might be responsible for up-regulating Aurora A for mitotic progression. Further analysis of the Aurora A promoter region indicates that the Ets element but not the Sp1 element is required for Compound A-sensitive transcriptional control of Aurora A. Overexpression of Aurora A in cells treated with Compound A attenuates the mitotic arrest and the defects in bipolar spindle formation induced by Akt inhibition. Our studies suggest that that Akt may promote mitotic progression through the transcriptional regulation of Aurora A.

  9. Latitudinally propagating on-off switching aurorae and associated geomagnetic pulsations

    International Nuclear Information System (INIS)

    Oguti, T.; Kokubun, S.; Hayashi, K.; Tsuruda, K.; Machida, S.; Kitamura, T.; Saka, O.; Watanabe, T.

    1981-01-01

    Poleward propagating on-off switching aurorae and equatorward propagating aurorae, otherwise similar, were observed simultaneously at Rabbit Lake and La Ronge, respectively, for about 40 min before dawn of Feb 20, 1980. Rabbit Lake is a high auroral latitude site at the northern end of the Saskatchewan chain of stations for the Pulsating Aurora Campaign, whereas La Ronge, due south of Rabbit, is almost at the southern edge of the auroral zone. The repetition periods of the on-off switching aurorae are about 6 to 13 s. The poleward propagating aurorae had well defined fronts of light which extended a few hundred kilometres or more in the east-west direction. The light fronts of the equatorward propagating aurorae, though comparable in extent, were less well defined: they were thicker and fuzzier. The poleward propagating aurorae moved with a speed of approximately 10 km/s whereas the equatorward ones did so with a slightly greater velocity. Geomagnetic field fluctuations were concurrent with the aurorae at both sites. At Rabbit Lake, northward (southward) field changes were associated with upward (downward) changes, whereas the trend is reversed at La Ronge, viz., northward (southward) changes with downward (upward) changes. These trends are consistent with a model of a periodic occurrence of two line currents, westward and eastward, the former moving poleward north of Rabbit Lake and the latter approaching La Ronge from the north

  10. Jupiter's Mid-Infrared Aurora: Solar Connection and Minor Constituents

    Science.gov (United States)

    Kostiuk, Theodore; Livengood, T.A.; Fast, K.E.; Hewagama, T.; Schmilling, F.; Sonnabend, G.; Delgado, J.

    2009-01-01

    High spectral resolution in the 12 pin region of the polar regions of Jupiter reveal unique information on auroral phenomena and upper stratospheric composition. Polar aurorae in Jupiter's atmosphere radiate; throughout the electromagnetic spectrum from X-ray through mid-infrared (mid-IR, 5 - 20 micron wavelength). Voyager IRIS data and ground-based. spectroscopic measurements of Jupiter's northern mid-IR aurora acquired since 1982, reveal a correlation between auroral brightness and solar activity that has not been observed in Jovian aurora at other wavelengths. Over nearly three solar cycles, Jupiter auroral ethane, emission brightness and solar 10.7-cm radar flux and sunspot number are positively correlated with high confidence. Ethane line emission intensity varies over tenfold between low and high scalar activity periods. Detailed measurements have been made using the GSFC HIPWAC spectrometer at the NASA IRTF since the last solar maximum, following the mid-IR emission through the declining phase toward solar minimum. An even more convincing correlation with solar activity is evident in these data. The spectra measured contain features that cannot be attributed to ethane and are most likely spectra of minor constituents whose molecular bands overlap the v9 band of ethane. Possible candidates are allene, propane, and other higher order hydrocarbons. These features appear to be enhanced in the active polar regions. Laboratory measurements at comparable spectral resolution of spectra of candidate molecules will be used to identify the constituents. Current analyses of these results will be described, including planned measurements on polar ethane line emission scheduled through the rise of the next solar maximum beginning in 2009, with a steep gradient to a maximum in 2012. This work is relevant to the Juno mission and to the development of the NASA/ESA Europa Jupiter System Mission.

  11. Double layers in the laboratory and above the aurora

    International Nuclear Information System (INIS)

    Block, L.P.

    1980-11-01

    Recent laboratory double layer experiments have simulated, much better than before, the conditions prevailing on auroral field lines at high altitudes. In particular, magnetic fields strong enough to magnetize the electrons (but not quite the ions) have been used. Particle and wave spectra have been measured. Wave-particle interaction has been shown to play a minor role in the only case that has been quantitatively analyzed. The three-dimensional potential distribution has been mapped. The particle budget requires the radial electric field to be outward in the no magnetic field case but inward with magnetic field, in agreement with what is observed above the aurora. (author)

  12. Dayside auroras in relation to the interplanetary magnetic field

    International Nuclear Information System (INIS)

    Sandholt, P.E.; Egeland, A.; Lybekk, B.; Deehr, C.S.

    1986-01-01

    Dynamics of dayside auroras, including cusp emissions, and their relation to the interplanetary magnetic field (IMF) have been investigated by optical ground-based observations from Svalbard, Norway, and IMF data from various satellites. Combined with the Svalbard program, simultaneous night-side observations from Alaska provide information on the large-scale behaviour of the auroral oval. Drift characteristics, spatial scale, time of duration and repetition frequency of auroral structures on the day-side, occuring at the time of large-scale oval expansions (IMF B z z positive and negative values

  13. Expression of Aurora-B and FOXM1 predict poor survival in patients with nasopharyngeal carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Pei-Yu; Luo, Dong-Hua; Mai, Hai-Qiang [State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou (China); Sun Yat-sen University Cancer Center, Department of Nasopharyngeal Carcinoma, Guangzhou (China); Li, Yan; Zeng, Ting-Ting; Li, Meng-Qing [State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou (China); Hou, Xue; Zhang, Li [State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou (China); Sun Yat-sen University Cancer Center, Department of Medical Oncology, Guangzhou (China)

    2015-08-15

    The purpose of this work was to investigate the relationship between Aurora-B, FOXM1, and clinical outcomes in patients with nasopharyngeal carcinoma (NPC) who were treated with a combination of induction chemotherapy and radiotherapy. The expression of Aurora-B and FOXM1 were investigated by immunohistochemistry using a tissue microarray (TMA) containing samples from 166 NPC patients who were treated with cisplatin (DDP) + fluorouracil (5-FU) induction chemotherapy and radiotherapy between 1999 and 2005. The relationship of Aurora-B, FOXM1, and survival of these NPC patients was analyzed. Informative TMA results were obtained in 91 tumor cases for Aurora-B and 93 tumor cases for FOXM1. The 8-year failure-free survival rate (FFS) for the Aurora-B-negative and Aurora-B-positive group was 65.6 and 37.3 %, respectively (p = 0.024), and the 8-year distant FFS (D-FFS) rate was 65.6 and 41.5 %, respectively (p = 0.047). The 8-year overall survival (OS) in the FOXM1-negative group was moderately higher than in the FOXM1-positive group (58.4 vs 39.1 %, p = 0.081). Cox regression analysis revealed that for FFS, Aurora-B expression was a significant prognostic factor (p = 0.025), while for D-FFS, Aurora-B expression was a marginally significant prognostic factor (p = 0.056). When FOXM1 expression was analyzed, the Cox regression analyses showed that FOXM1 expression was a marginally significant prognostic factor (p = 0.056) for OS. Correlation analysis showed that Aurora-B and FOXM1 expression had no significant correlation. Aurora-B and FOXM1 were both adverse prognostic markers for NPC patients treated with chemoradiotherapy. However, the two markers had no significant correlation. (orig.) [German] Ziel war die Untersuchung der Beziehung zwischen Aurora-B, FOXM1 und den klinischen Ergebnissen bei Patienten mit nasopharyngealem Karzinom (NPC), die mit einer Kombinationstherapie aus Induktionschemotherapie und Radiotherapie behandelt wurden. Die Expression von Aurora-B und

  14. Correspondence of vacuum ultraviolet aurora image with the inverted-V structure observed by Kyokko

    International Nuclear Information System (INIS)

    Kaneda, Eisuke; Mukai, Toshifumi; Hirao, Kunio.

    1982-01-01

    Since the Kyokko has been in an orbit with the inclination of 65.3 degree, various patterns of the inverted-V structure can be observed. Correspondence of vacuum ultraviolet aurora image with the inverted-V structure was studied. The energy-time diagrams were obtained. The inverted-V event occurrence map was made. The down-dusk asymmetry was recognized. The patterns of the inverted-V structure observed at present were not much different from previous ones. The observed aurora images showed not only the patterns of aurora, but also the state of aurora spreading in the polar region. Some of the observed results of energy characteristics and the aurora images are shown. (Kato, T.)

  15. The Aurora B kinase in chromosome biorientation and spindle checkpoint signalling

    Directory of Open Access Journals (Sweden)

    Veronica eKrenn

    2015-10-01

    Full Text Available Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player in chromosome segregation. As part of a macromolecular complex known as the chromosome passenger complex, Aurora B concentrates early during mitosis in the proximity of centromeres and kinetochores, the sites of attachment of chromosomes to spindle microtubules. There, it contributes to a number of processes that impart fidelity to cell division, including kinetochore stabilization, kinetochore-microtubule attachment, and the regulation of a surveillance mechanism named the spindle assembly checkpoint. In the regulation of these processes, Aurora B is the fulcrum of a remarkably complex network of interactions that feed back on its localization and activation state. In this review we discuss the multiple roles of Aurora B during mitosis, focusing in particular on its role at centromeres and kinetochores. Many details of the network of interactions at these locations remain poorly understood, and we focus here on several crucial outstanding questions.

  16. Horonobe Underground Research Laboratory project. Synthesis of phase II (construction phase) investigations to a depth of 350 m

    International Nuclear Information System (INIS)

    Sato, Toshinori; Sasamoto, Hiroshi; Ishii, Eiichi; Matsuoka, Toshiyuki; Hayano, Akira; Miyakawa, Kazuya; Fujita, Tomoo; Tanai, Kenji; Nakayama, Masashi; Takeda, Masaki; Yokota, Hideharu; Aoyagi, Kazuhei; Ohno, Hirokazu; Shigeta, Naotaka; Hanamuro, Takahiro; Ito, Hiroaki

    2017-03-01

    The Horonobe Underground Research Laboratory (URL) Project is being pursued by the Japan Atomic Energy Agency (JAEA) to enhance the reliability of relevant disposal technologies through investigations of the deep geological environment within the host sedimentary formations at Horonobe, northern Hokkaido. The project consists of two major research areas, 'Geoscientific Research' and 'R and D on Geological Disposal', and proceeds in three overlapping phases, 'Phase I: Surface-based investigation', 'Phase II: Construction' and 'Phase III: Operation', over a period of 20 years. This report summarizes the results of the Phase II investigations carried out from April 2005 to June 2014 to a depth of 350 m. Integration of work from different disciplines into a 'geosynthesis' ensures that the Phase II goals have been successfully achieved and identifies key issues that need to be addressed in the Phase II investigations. Efforts are made to summarize as many lessons learnt from the Phase II investigations and other technical achievements as possible to form a 'knowledge base' that will reinforce the technical basis for both implementation and the formulation of safety regulations. (author)

  17. Basal aurora kinase B activity is sufficient for histone H3 phosphorylation in prophase

    Directory of Open Access Journals (Sweden)

    Ly-Thuy-Tram Le

    2013-02-01

    Histone H3 phosphorylation is the hallmark of mitosis deposited by aurora kinase B. Benzo[e]pyridoindoles are a family of potent, broad, ATP-competitive aurora kinase inhibitors. However, benzo[e]pyridoindole C4 only inhibits histone H3 phosphorylation in prophase but not in metaphase. Under the C4 treatment, the cells enter into mitosis with dephosphorylated histone H3, assemble chromosomes normally and progress to metaphase, and then to anaphase. C4 also induces lagging chromosome in anaphase but we demonstrated that these chromosome compaction defects are not related to the absence of H3 phosphorylation in prophase. As a result of C4 action, mitosis lasts longer and the cell cycle is slowed down. We reproduced the mitotic defects with reduced concentrations of potent pan aurora kinase as well as with a specific aurora B ATP-competitive inhibitor; we therefore propose that histone H3 phosphorylation and anaphase chromosome compaction involve the basal activity of aurora kinase B. Our data suggest that aurora kinase B is progressively activated at mitosis entry and at anaphase onset. The full activation of aurora kinase B by its partners, in prometaphase, induces a shift in the catalytic domain of aurora B that modifies its affinity for ATP. These waves of activation/deactivation of aurora B correspond to different conformations of the chromosomal complex revealed by FRAP. The presence of lagging chromosomes may have deleterious consequences on the daughter cells and, unfortunately, the situation may be encountered in patients receiving treatment with aurora kinase inhibitors.

  18. PENGEMBANGAN ASESMEN ALTERNATIF PRAKTIKUM KIMIA DASAR II MELALUI CHEMISTRY FAIR PROJECT (CFP BERBASIS KONSERVASI DENGAN MEMANFAATKAN DAILY CHEMICAL

    Directory of Open Access Journals (Sweden)

    Indah Urwatin Wusqo

    2016-12-01

    Full Text Available Penelitian ini bertujuan untuk (1 Mengembangkan asesmen alternatif pada praktikum kimia dasar II melalui chemistry fair project berbasis konservasi dengan memanfaatkan daily chemical(2 Mengetahui tingkat kevalidan, kepraktisan dan keefektifannya. Penelitian ini merupakan penelitian pengembangan (Development Research Model pengembangan yang diterapkan Dick dan Carey (1985. Subjek uji coba terbatas maupun subjek uji coba lapangan adalah dosen dan mahasiswa Prodi Pendidikan IPA UNNES. Sampel ditentukan secara purposive, yaitu dosen pengampu dan mahasiswa yang menempuh mata kuliah Praktikum Kimia Dasar II. Data yang diperoleh dari uji coba ini adalah: (1 masukan dari pakar, untuk menentukan validitas isi dan konstruk dari fitur asesmen; (2 masukan dari sampel uji coba terbatas, untuk menentukan kepraktisan petunjuk chemistry fair project (CFP berbasis konservasi dengan memanfaatkan daily chemical ; Instrumen pengumpul data berupa angket keterbacaan petunjuk pembuatan chemistry fair project (CFP berbasis konservasi dengan memanfaatkan daily chemical, pedoman penskoran. (3 data hasil belajar siswa untuk mengetahui efektivitas asesmen. Masukan dari pakar angket mahasiswa, dan nilai chemistry fair project (CFP sampel ujicoba terbatas dianalisis secara kualitatif, dan kuantitatif. Asesmen alternative Praktikum Kimia Dasar II yang dikembangkan dikatakan berhasil baik apabila asesmen yang dikembangkan valid, praktis, dan efektif.

  19. World War II, The CANOL project and the Marwell Tar Pit: a case study

    International Nuclear Information System (INIS)

    Dobrowolsky, H.

    2000-01-01

    The CANOL project was a joint U.S.-Canada undertaking during World War II. It entailed the construction of a road and pipeline from the oil fields of Norman Wells on the Mackenzie River, 960 kms over the Mackenzie Mountains to a new refinery at Whitehorse. The goal was to provide a secure supply of aviation fuel far from the menace of Japanese bombers. Initially, the pipeline was expected to operate by October 1942. In actual fact, the first gasoline was not produced in the crude distillation unit until April 24, 1944, and it was not until November 1944 that the refinery finally began producing aviation fuel. Four months later, the pipeline and the refinery were shut down. The project cost American taxpayers $ 134 million. A total of 2650 kms of pipeline was laid. During the first nine months of pipeline operation 46,000 barrels of oil was spilled, much of it directly into the Mackenzie River. Total production from the refinery, which itself cost $ 27 million, wa 866,670 barrels of products. When the refinery was shut down, most of the refinery structures were dismantled and moved, via the Alaska Highway, to the newly discovered Leduc oilfields, but buildings, tanks and hydrocarbon waste were left behind. In a 1960 report it was estimated that some four million litres of oil has been pumped into a pit located within the containment berm formerly surrounding an 80,000 barrel oil storage tank which was dismantled after the shutdown. The bureaucratic dispute about who is responsible for cleaning up has been an issue ever since. The cost of cleanup was estimated at about $ 4 million in 1994. Since the federal government, the original owners of the land , transferred the land to provincial jurisdiction in 1970, it disclaimed any responsibility for site cleanup, however, there has been some recent evidence of willingness on the part of the Department of National Defence and the Department of Indian and Northern Affairs to determine proper actions to clean up the site

  20. Development and field evaluation of animal feed supplementation packages (AFRA project II-17 - RAF/5/041). Project summary

    International Nuclear Information System (INIS)

    Makkar, H.P.S.

    2002-01-01

    The Joint FAO/IAEA programme has supported animal production research in Africa for many years through country Technical Co-operation (TC) Projects, Regional Projects (AFRA) and Co-ordinated Research Project (CRP). These activities have helped to build up the infrastructure needed in the countries concerned to conduct much of the research in animal reproduction and nutrition. In the past the Agency has provided technical assistance in defining reproductive indices of ruminant livestock species and identifying nutritional constraints to productivity of animals maintained on smallholder farms under various topographical and environmental conditions. In view of the satisfactory progress of AFRA Project VIII in identifying the major constraints to livestock productivity in the region, and the recognition of many Member States of the importance of supplementary feeding for improving milk and meat production, a regional strategy was proposed for developing affordable and sustainable supplementation packages for improving productivity from smallholder farms using locally available feed resources. The new Regional Project was initiated in 1997 with the following objectives: 1. To produce a supplementary feed in the form of a convenient and easy-to-use package for improving milk and meat production in peri-urban areas 2. To promote the uptake of this technology through demonstrations of its advantages in terms of increased productivity and benefit: cost ratio 3. To maximize the use of locally available feed material such as molasses, cereal bran, legume tree leaves, oil seed meals, etc. for feeding ruminant livestock, thereby reducing the use of high cost concentrate feeds 4. To promote technical co-operation amongst developing countries (TCDC) in the region and take advantage of established infrastructure and available human and technical resources to solve problems of common interest. From 1997 until 2000 the project has been operational with 13 Member States

  1. X-ray scanning of overhead aurorae from rockets

    International Nuclear Information System (INIS)

    Barcus, J.R.; Goldberg, R.A.

    1981-01-01

    Two Nike Tomahawk rocket payloads were launched into energetic auroral events to investigate their structure and effects on the atmosphere. The instrument complement included X-ray scintillation detectors with energy discrimination in four ranges to measure the deposition of bremsstrahlung produced X-rays within the stratosphere and mesosphere. For this purpose, each instrument was designed for wide angle viewing; however, properties of the rocket motion have permitted coarse observation of distinct spatial X-ray structure. The detectors were mounted at a 45 0 angle with respect to the payload axis to permit scanning of the upper hemisphere, with rocket spin rates near 5 c/s during the upleg portion of each flight. Here, atmospheric shielding reduced energetic particle contamination effects to insignificant values below 65 to 75 km. Iterative computer techniques were used to reconstruct X-ray source maps at 100 km, taking atmospheric absorption effects into account. Payload 18.178 was launched on 21 September (0302 LMT) into an aurora observed to have two distinct azimuthal regions of optical brightness. Payload 18.179 (23 September, 0147 LMT) was launched into an aurora of more diffuse character. The presence of a two component spectrum is indicated for each event with the hard component originating in the more diffuse, optically faint regions. (author)

  2. Terrestrial aurora: astrophysical laboratory for anomalous abundances in stellar systems

    Directory of Open Access Journals (Sweden)

    I. Roth

    2014-02-01

    Full Text Available The unique magnetic structure of the terrestrial aurora as a conduit of information between the ionosphere and magnetosphere can be utilized as a laboratory for physical processes at similar magnetic configurations and applied to various evolutionary phases of the solar (stellar system. The most spectacular heliospheric abundance enhancement involves the 3He isotope and selective heavy elements in impulsive solar flares. In situ observations of electromagnetic waves on active aurora are extrapolated to flaring corona in an analysis of solar acceleration processes of 3He, the only element that may resonate strongly with the waves, as well as heavy ions with specific charge-to-mass ratios, which may resonate weaker via their higher gyroharmonics. These results are applied to two observed anomalous astrophysical abundances: (1 enhanced abundance of 3He and possibly 13C in the late stellar evolutionary stages of planetary nebulae; and (2 enhanced abundance of the observed fossil element 26Mg in meteorites as a decay product of radioactive 26Al isotope due to interaction with the flare-energized 3He in the early solar system.

  3. Dynamic rayed aurora and enhanced ion-acoustic radar echoes

    Directory of Open Access Journals (Sweden)

    E. M. Blixt

    2005-01-01

    Full Text Available The generation mechanism for naturally enhanced ion-acoustic echoes is still debated. One important issue is how these enhancements are related to auroral activity. All events of enhanced ion-acoustic echoes observed simultaneously with the EISCAT Svalbard Radar (ESR and with high-resolution narrow field-of-view auroral imagers have been collected and studied. Characteristic of all the events is the appearance of very dynamic rayed aurora, and some of the intrinsic features of these auroral displays are identified. Several of these identified features are directly related to the presence of low energy (10-100eV precipitating electrons in addition to the higher energy population producing most of the associated light. The low energy contribution is vital for the formation of the enhanced ion-acoustic echoes. We argue that this type of aurora is sufficient for the generation of naturally enhanced ion-acoustic echoes. In one event two imagers were used to observe the auroral rays simultaneously, one from the radar site and one 7km away. The data from these imagers shows that the auroral rays and the strong backscattering filaments (where the enhanced echoes are produced are located on the same field line, which is in contrast to earlier statements in the litterature that they should be separated.

  4. Pulsating aurora from electron scattering by chorus waves

    Science.gov (United States)

    Kasahara, S.; Miyoshi, Y.; Yokota, S.; Mitani, T.; Kasahara, Y.; Matsuda, S.; Kumamoto, A.; Matsuoka, A.; Kazama, Y.; Frey, H. U.; Angelopoulos, V.; Kurita, S.; Keika, K.; Seki, K.; Shinohara, I.

    2018-02-01

    Auroral substorms, dynamic phenomena that occur in the upper atmosphere at night, are caused by global reconfiguration of the magnetosphere, which releases stored solar wind energy. These storms are characterized by auroral brightening from dusk to midnight, followed by violent motions of distinct auroral arcs that suddenly break up, and the subsequent emergence of diffuse, pulsating auroral patches at dawn. Pulsating aurorae, which are quasiperiodic, blinking patches of light tens to hundreds of kilometres across, appear at altitudes of about 100 kilometres in the high-latitude regions of both hemispheres, and multiple patches often cover the entire sky. This auroral pulsation, with periods of several to tens of seconds, is generated by the intermittent precipitation of energetic electrons (several to tens of kiloelectronvolts) arriving from the magnetosphere and colliding with the atoms and molecules of the upper atmosphere. A possible cause of this precipitation is the interaction between magnetospheric electrons and electromagnetic waves called whistler-mode chorus waves. However, no direct observational evidence of this interaction has been obtained so far. Here we report that energetic electrons are scattered by chorus waves, resulting in their precipitation. Our observations were made in March 2017 with a magnetospheric spacecraft equipped with a high-angular-resolution electron sensor and electromagnetic field instruments. The measured quasiperiodic precipitating electron flux was sufficiently intense to generate a pulsating aurora, which was indeed simultaneously observed by a ground auroral imager.

  5. Arsenic-induced Aurora-A activation contributes to chromosome instability and tumorigenesis

    Science.gov (United States)

    Wu, Chin-Han; Tseng, Ya-Shih; Yang, Chao-Chun; Kao, Yu-Ting; Sheu, Hamm-Ming; Liu, Hsiao-Sheng

    2013-11-01

    Arsenic may cause serious environmental pollution and is a serious industrial problem. Depending on the dosage, arsenic may trigger the cells undergoing either proliferation or apoptosis-related cell death. Because of lack of the proper animal model to study arsenic induced tumorigenesis, the accurate risk level of arsenic exposure has not been determined. Arsenic shows genotoxic effect on human beings who uptake water contaminated by arsenic. Chromosome aberration is frequently detected in arsenic exposure-related diseases and is associated with increased oxidative stress and decreased DNA repairing activity, but the underlying mechanism remains elusive. Aurora-A is a mitotic kinase, over-expression of Aurora-A leads to centrosome amplification, chromosomal instability and cell transformation. We revealed that Aurora-A is over-expressed in the skin and bladder cancer patients from blackfoot-disease endemic areas. Our cell line studies reveal that arsenic exposure between 0.5 μM and 1 μM for 2-7 days are able to induce Aurora-A expression and activation based on promoter activity, RNA and protein analysis. Aurora-A overexpression further increases the frequency of unsymmetrical chromosome segregation through centrosome amplification followed by cell population accumulated at S phase in immortalized keratinocyte (HaCaT) and uroepithelial cells (E7). Furthermore, Aurora-A over-expression was sustained for 1-4 weeks by chronic treatment of immortalized bladder and skin cells with NaAsO2. Aurora-A promoter methylation and gene amplification was not detected in the long-term arsenic treated E7 cells. Furthermore, the expression level of E2F1 transcription factor (E2F1) is increased in the presence of arsenic, and arsenic-related Aurora-A over-expression is transcriptionally regulated by E2F1. We further demonstrated that overexpression of Aurora-A and mutant Ha-ras or Aurora-A and mutant p53 may act additively to trigger arsenic-related bladder and skin cancer

  6. The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma.

    Science.gov (United States)

    Evans, Robert P; Naber, Claudia; Steffler, Tara; Checkland, Tamara; Maxwell, Christopher A; Keats, Jonathan J; Belch, Andrew R; Pilarski, Linda M; Lai, Raymond; Reiman, Tony

    2008-02-01

    Aurora kinases are potential targets for cancer therapy. Previous studies have validated Aurora kinase A as a therapeutic target in multiple myeloma (MM), and have demonstrated in vitro anti-myeloma effects of small molecule Aurora kinase inhibitors that inhibit both Aurora A and B. This study demonstrated that Aurora B kinase was strongly expressed in myeloma cell lines and primary plasma cells. The selective Aurora B inhibitor AZD1152-induced apoptotic death in myeloma cell lines at nanomolar concentrations, with a cell cycle phenotype consistent with that reported previously for Aurora B inhibition. In some cases, AZD1152 in combination with dexamethasone showed increased anti-myeloma activity compared with the use of either agent alone. AZD1152 was active against sorted CD138(+) BM plasma cells from myeloma patients but also, as expected, was toxic to CD138(-) marrow cells from the same patients. In a murine myeloma xenograft model, AZD1152-inhibited tumour growth at well-tolerated doses and induced cell death in established tumours, with associated mild, transient leucopenia. AZD1152 shows promise in these preclinical studies as a novel treatment for MM.

  7. Survivin inhibits anti-growth effect of p53 activated by aurora B

    International Nuclear Information System (INIS)

    Jung, Ji-Eun; Kim, Tae-Kyung; Lee, Joong-Seob; Oh, Se-Yeong; Kwak, Sungwook; Jin, Xun; Sohn, Jin-Young; Song, Min-Keun; Sohn, Young-Woo; Lee, Soo-Yeon; Pian, Xumin; Lee, Jang-Bo; Chung, Yong Gu; Choi, Young Ki; You, Seungkwon; Kim, Hyunggee

    2005-01-01

    Genomic instability and apoptosis evasion are hallmarks of cancer, but the molecular mechanisms governing these processes remain elusive. Here, we found that survivin, a member of the apoptosis-inhibiting gene family, and aurora B kinase, a chromosomal passenger protein, were co-overexpressed in the various glioblastoma cell lines and tumors. Notably, exogenous introduction of the aurora B in human BJ cells was shown to decrease cell growth and increase the senescence-associated β-galactosidase activity by activation of p53 tumor suppressor. However, aurora B overexpression failed to inhibit cell proliferation in BJ and U87MG cells transduced with dominant-negative p53 as well as in p53 -/- mouse astrocytes. Aurora B was shown to increase centrosome amplification in the p53 -/- astrocytes. Survivin was shown to induce anchorage-independent growth and inhibit anti-proliferation and drug-sensitive apoptosis caused by aurora B. Overexpression of both survivin and aurora B further accelerated the proliferation of BJ cells. Taken together, the present study indicates that survivin should accelerate tumorigenesis by inhibiting the anti-proliferative effect of p53 tumor suppressor that is activated by aurora B in normal and glioblastoma cells containing intact p53

  8. A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Pérez de Castro, Ignacio; Aguirre-Portolés, Cristina [Molecular Oncology Programme, Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncológicas, Madrid (Spain); Martin, Benedicte [CNRS-UMR 6061, Institut de Génétique et Développement de Rennes, IFR 140 GFAS, Faculté de Médecine, Université Rennes 1, Rennes (France); Fernández-Miranda, Gonzalo [Molecular Oncology Programme, Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncológicas, Madrid (Spain); Klotzbucher, Andrea; Kubbutat, Michael H. G. [ProQinase GmBH, Freiburg (Germany); Megías, Diego [Confocal Microscopy Core Unit, Centro Nacional de Investigaciones Oncológicas, Madrid (Spain); Arlot-Bonnemains, Yannick [CNRS-UMR 6061, Institut de Génétique et Développement de Rennes, IFR 140 GFAS, Faculté de Médecine, Université Rennes 1, Rennes (France); Malumbres, Marcos, E-mail: mmm@cnio.es, E-mail: iperez@cnio.es [Molecular Oncology Programme, Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncológicas, Madrid (Spain)

    2011-12-14

    Aurora-A is a serine/threonine kinase that plays critical roles in centrosome maturation, spindle dynamics, and chromosome orientation and it is frequently over-expressed in human cancers. In this work, we show that Aurora-A interacts with the SUMO-conjugating enzyme UBC9 and co-localizes with SUMO1 in mitotic cells. Aurora-A can be SUMOylated in vitro and in vivo. Mutation of the highly conserved SUMOylation residue lysine 249 significantly disrupts Aurora-A SUMOylation and mitotic defects characterized by defective and multipolar spindles ensue. The Aurora-A{sup K249R} mutant has normal kinase activity but displays altered dynamics at the mitotic spindle. In addition, ectopic expression of the Aurora-A{sup K249R} mutant results in a significant increase in susceptibility to malignant transformation induced by the Ras oncogene. These data suggest that modification by SUMO residues may control Aurora-A function at the spindle and that deficiency of SUMOylation of this kinase may have important implications for tumor development.

  9. Effect of participation in the Fadama–II project on Participants' socio ...

    African Journals Online (AJOL)

    For most respondents, the socioeconomic status changed positively following participation in the project. Majority of the respondents in the study area participated actively in fadama meetings and other activities involved in project. Benefits derived from taking part in the project were generally high for most respondents (95.5 ...

  10. Results of the project 'combustion modelling' (BKM II); Ergebnisse des Projekts 'Brennkammermodellierung' (BKM II)

    Energy Technology Data Exchange (ETDEWEB)

    Noll, B.; Rachner, M.; Frank, P.; Schmitz, G.; Geigle, K.P.; Meier, W.; Schuetz, H.; Aigner, M. [DLR Deutsches Zentrum fuer Luft- und Raumfahrt e.V., Stuttgart (Germany). Inst. fuer Verbrennungstechnik; Kessler, R. [DLR Deutsches Zentrum fuer Luft- und Raumfahrt e.V., Goettingen (Germany). Inst. fuer Aerodynamik und Stroemungstechnik; Lehmann, B. [DLR Deutsches Zentrum fuer Luft- und Raumfahrt e.V., Koeln (Germany). Inst. fuer Antriebstechnik; Forkert, T. [DLR Deutsches Zentrum fuer Luft- und Raumfahrt e.V., Koeln (Germany). Simulation und Softwaretechnik

    2002-07-01

    In the year 1996 the spheres of competence of several DLR-Institutes working in the areas of fluid dynamics, reaction kinetics, combustion, numerical methods and laser measuring techniques have been brought together while contributing to the internal DLR project 'combustion chamber modelling (BKM)', in order to proceed with the computational simulation of combustion processes in combustion chambers of gas turbines. The main issue was the development of a research code for numerical simulation of fluid flow in real combustion chambers. Here the development of computational models of physical and chemical processes was emphasized, among other processes the formation of soot was treated. Moreover, a worldwide outstanding database of measured data for the purpose of code validation has been created within the framework of the BKM project using the laboratory facilities of the DLR, which are in Germany unique for the experimental investigation of the various processes in combustion chambers of gas turbines. The project BKM is part of the specific DLR-programme 'energy'. With the successful completion of the first phase of the project in 1998, a second project phase of three years (BKM II) has been launched at the beginning of 1999. Here the work of the first phase continued and new topics were tackled. The second phase of the project was partly founded by the DLR-programme 'aeronautics'. (orig.) [German] Im Jahr 1996 wurden die Faehigkeiten mehrerer DLR-Institute auf den Gebieten Stroemungsmechanik, Reaktionskinetik, Verbrennung sowie Numerische Verfahren und Laser-Messverfahren in dem DLR-internen Projekt 'Brennkammermodellierung' (BKM) zusammengefuehrt, um die rechnerische Simulation der Verbrennungsvorgaenge in Gasturbinen-Brennkammern voranzutreiben. Dabei war die Entwicklung eines Forschungscodes zur numerischen Simulation von realen Brennkammerstroemungen das vorrangige Ziel der Arbeiten. Ein besonderes Schwergewicht lag

  11. Educación Compensatoria. Aprendizaje temprano, éxito posterior (II: Carolina Abecedarian Project . [Compensatory education. Early learning, later success (II: Carolina Abecedarian Project

    Directory of Open Access Journals (Sweden)

    Eduardo López López

    2007-01-01

    Full Text Available This is a review study which analyzes research that evaluates the long term effects of an early education program, the Abecedarian Project. The Abecedarian Project (ABC is a preventive compensatory education program for children from 0 to 5 years of high risk mothers. The experimental group (E received an intensive preschool treatment, while the control (C group did not. At five years old, each group was divided into another two groups: Two of these new groups (EE and CE received intensive schooling until the children reached 8 years old, while the other groups (EC and CC received no special treatment. The total sample was measured until each child reached 21 years. The results were as follows: The young adults, treated in the preschool years, had on average significantly higher cognitive test scores, earned higher scores on reading and math tests; they completed more years of education, they were more likely to attend a 4-year college or university, and they were less likely to become teen parents. Furthermore, the mothers of these students were more likely to reach a higher level of instruction and employment. Finally, the article discusses the validity of the study and the factors associated to the benefits (the early beginning, intensity and continuity of the program. Este es un estudio de revisión en el que se analizan las investigaciones que evalúan los efectos a lo largo del tiempo del temprano Abecedarian Project (ABC. El ABC es un programa compensador preventivo de 0-5 años y entresacados de madres de alto riesgo. El grupo experimental (E recibe tratamiento preescolar intensivo, no el control (C. Se prolongó escolarmente hasta los 8 años, subdividiéndose ambos grupos: Dos -EE y CE- recibieron tratamiento intensivo; otros (EC y CC convencional. Fueron medidos hasta los 21. Resultados: Los jóvenes adultos, tratados preescolarmente, mejoraron en rendimiento mental, lector y matemático; alcanzaron mayores instrucción y presencia en

  12. Development of advanced blanket performance under irradiation and system integration through JUPITER-II project

    Energy Technology Data Exchange (ETDEWEB)

    Abe, Katsunori; Kohyama, Akira; Tanaka, Satoru; Namba, C.; Terai, T.; Kunugi, T.; Muroga, Takeo; Hasegawa, Akira; Sagara, A.; Berk, S.; Zinkle, Steven J.; Sze, Dai Kai; Petti, D. A.; Abdou, Mohamed A.; Morley, Neil B.; Kurtz, Richard J.; Snead, Lance L.; Ghoniem, Nasr M.

    2008-12-01

    This report describes an outline of the activities of the JUPITER-II collaboration (japan-USA program of Irradiation/Integration test for Fusion Research-II), Which has bee carried out through six years (2001-2006) under Phase 4 of the collabroation implemented by Amendment 4 of Annex 1 to the DOE (United States Department of Energy)-MEXT (Ministry of Education ,Culture,Sports,Science and Technology) Cooperation. This program followed the RTNS-II Program (Phase1:1982-4986), the FFTF/MOTA Program (Phase2:1987-1994) and the JUPITER Program (Phase 3: 1995-2000) [1].

  13. Simulations of the neutral structure within the dusk side aurora

    Directory of Open Access Journals (Sweden)

    H. F. Parish

    2006-10-01

    Full Text Available Observations of neutral winds from rocket release experiments within the premidnight and postmidnight substorm recovery phase aurora, show very large E-region neutral winds of several hundred m/s, where winds measured on the dusk side are even larger than those on the dawn side. These large winds are also associated with strong shears, and there is evidence that some of the regions below these shears may be unstable. The mechanisms which generate this strong vertical structure are not well understood. It is also not known whether the acceleration conditions in the pre and post midnight sectors of the aurora may produce significantly different neutral responses on the dawn and dusk sides. Simulations have been performed using a three-dimensional high resolution limited area thermosphere model to try to understand the neutral structure within the dawn and dusk side aurora. When simulations are performed using auroral forcing alone, for equivalent conditions within the dawn and dusk sectors, differences are found in the simulated response on each side. When measured values of auroral forcing parameters, and background winds and tides consistent with recent observations, are used as model inputs, some of the main features of the zonal and meridional wind observations are reproduced in the simulations, but the magnitude of the peak zonal wind around 140 km tends to be too small and the maximum meridional wind around 130 km is overestimated. The winds above 120 km altitude are found to be sensitive to changes in electric fields and ion densities, as was the case for the dawn side, but the effects of background winds and tides on the magnitudes of the winds above 120 km are found to be relatively small on the dusk side. The structure below 120 km appears to be related mainly to background winds and tides rather than auroral forcing, as was found in earlier studies on the dawn side, although the peak magnitudes of simulated wind variations in the 100 to

  14. Scientists help the children of Chernobyl. The GAST/VDEW project. Report on phase II: 1. April 1996 - 31. March 1998

    International Nuclear Information System (INIS)

    Reiners, Ch.; Biko, J.; Streffer, C.

    2000-05-01

    In this project phase II, from 1. April 1996 until 31. March 1998, the activities under the four partial projects entitled 'Therapy and training', 'Biological dosimetry', 'Dosimetry and risk assessment', and 'Coordination and examination authority at Minsk' have been continued and concluded, except for the partial project 'Therapy and training'. (orig./CB) [de

  15. An introduction to the PISC II project - programme for the inspection of steel components

    International Nuclear Information System (INIS)

    Nichols, R.; McDonald, N.R.

    1987-01-01

    The paper describes the work of the Plate Inspection Steering Committee (PISC) on the non-destructive examination of reactor pressure vessel steels. A description is given of the PISC I exercise on flaw measurements in test plates, including the PISC procedure and the alternative procedures in the PISC I exercise. The motivation for a PISC II programme is described, together with the objectives and terms of reference of PISC II. (U.K.)

  16. Aurorasaurus Database of Real-Time, Soft-Sensor Sourced Aurora Data for Space Weather Research

    Science.gov (United States)

    Kosar, B.; MacDonald, E.; Heavner, M.

    2017-12-01

    Aurorasaurus is an innovative citizen science project focused on two fundamental objectives i.e., collecting real-time, ground-based signals of auroral visibility from citizen scientists (soft-sensors) and incorporating this new type of data into scientific investigations pertaining to aurora. The project has been live since the Fall of 2014, and as of Summer 2017, the database compiled approximately 12,000 observations (5295 direct reports and 6413 verified tweets). In this presentation, we will focus on demonstrating the utility of this robust science quality data for space weather research needs. These data scale with the size of the event and are well-suited to capture the largest, rarest events. Emerging state-of-the-art computational methods based on statistical inference such as machine learning frameworks and data-model integration methods can offer new insights that could potentially lead to better real-time assessment and space weather prediction when citizen science data are combined with traditional sources.

  17. Beam propagation considerations in the Aurora laser system

    International Nuclear Information System (INIS)

    Rosoche, L.A.; Mc Leod, J.; Hanlon, J.A.

    1987-01-01

    Aurora is a high-power KrF laser system now being constructed for inertial confinement fusion (ICF) studies. It will use optical angular multiplexing and serial amplification by electron-beam-driven KrF amplifiers to deliver a stacked, multikilojoule 5-ns-duration laser pulse to ICF targets. The requirements of angular multiplexing KrF lasers at the multikilojoule level dictate path lengths on the order of 1 km. The inherent complicated path crossings produced by angular multiplexing and pulse stacking do not allow isolation of individual beam lines, so the optical quality of the long beam paths must be controlled. Propagation of the 248-nm light beams over long paths in air is affected by scattering, absorption thermal gradients and turbulence, beam alignment, and control and optical component figure errors

  18. Environmental impact assessment for the Syncrude Aurora Mine

    International Nuclear Information System (INIS)

    1996-01-01

    Syncrude Canada has applied to the Alberta Energy and Utilities Board (AEUB) and Alberta Environmental Protection for approval to construct and operate the Aurora Mine, its new oil sands mine and associated bitumen facilities located 70 km northeast of Fort McMurray, Alberta. Volume 1, the principal volume in the set of 31 volumes, includes the detailed assessment of environmental effects on air quality, noise, surface water flows, surface water quality, groundwater flow and quality, geology, terrain and soils overburden, fisheries and aquatic resources, vegetation and resource use, wildlife population and habitat, human health and public safety. Baseline data for each of the above areas are contained in separate volumes. 400 refs., 162 tabs., 190 figs

  19. The charge spectrum of positive ions in a hydrogen aurora

    Science.gov (United States)

    Lynch, J.; Pulliam, D.; Leach, R.; Scherb, F.

    1976-01-01

    An auroral ion charge spectrometer was flown into a hydrogen aurora on a Javelin sounding rocket launched from Churchill, Manitoba. The instrument contained an electrostatic analyzer which selected particles with incident energy per unit charge up to 20 keV/charge and an 80-kV power supply which accelerated these ions onto an array of solid state detectors. Ions tentatively identified as H(+), He(+2), and O(+) were detected from 225 to 820 km in altitude. The experiment did not discriminate between H(+) and He(+), or between O(+), N(+), and C(+). Upper limits of highly charged heavy ion abundances have been set at 20% of the He(+2) and 0.15% of the H(+). It is concluded that both terrestrial and solar wind sources play significant roles in auroral ion precipitation.

  20. Exploring the Secrets of the Aurora Second Edition

    CERN Document Server

    Akasofu, Syun-Ichi

    2007-01-01

    This new edition of Exploring the Secrets of the Aurora is based on the author's own experiences as a scientist. It describes the history of progress made in auroral science and magnetospheric physics by providing examples of ideas, controversies, struggles, acceptance, and success. Although no general methodologies are mentioned, the hope is that the reader will learn about the history of progress in auroral science and examples of dealing with the many controversies. This book aims to help young scientific researchers learn how to persevere during periods of controversy and struggles for acceptance. In this second edition, by utilizing multiple examples, Akasofu is successful in demonstrating the importance and usefulness of Synthesis. "Probably the book's most valuable contribution to the history of space physics is precisely the narration of the discovery of substorms.---The book has special features.---Akasofu's coverage of the history of pre-space age solar-terrestrial relations is the most comprehensiv...

  1. Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells.

    Science.gov (United States)

    Evans, Robert; Naber, Claudia; Steffler, Tara; Checkland, Tamara; Keats, Jonathan; Maxwell, Christopher; Perry, Troy; Chau, Heidi; Belch, Andrew; Pilarski, Linda; Reiman, Tony

    2008-03-01

    The expression of RHAMM and other centrosome-associated genes are known to correlate with the extent of centrosome amplification in multiple myeloma, and with poor prognosis. RHAMM has a significant interaction with TPX2, a protein which regulates the localization and action of Aurora A kinase (AURKA) at the spindle poles. AURKA is known to be a central determinant of centrosome and spindle function and is a target for cancer therapy. Given these observations, we investigated the role of Aurora kinases as therapeutic targets in myeloma. Here we report that AURKA is expressed ubiquitously in myeloma, to varying degrees, in both cell lines and patients' bone marrow plasma cells. siRNA targeting AURKA induces apoptotic cell death in myeloma cell lines. The Aurora kinase inhibitor VE-465 also induces apoptosis and death in myeloma cell lines and primary myeloma plasma cells. The combination of VE-465 and dexamethasone improves cell killing compared with the use of either agent alone, even in cells resistant to the single agents. The phenotype of myeloma cells treated with VE-465 is consistent with published reports on the effects of Aurora kinase inhibition. Aurora kinase inhibitors should be pursued as potential treatments for myeloma.

  2. Wind River Watershed Restoration Project, Segment II, 2000-2002 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Bair, Brian; Olegario, Anthony; Powers, Paul

    2002-06-01

    This document represents work conducted as part of the Wind River Watershed Restoration Project during its second year of funding through the Bonneville Power Administration (BPA). The project is a comprehensive effort involving public and private entities seeking to restore water quality and fishery resources in the basin through cooperative actions. Project elements include coordination, watershed assessment, restoration, monitoring, and education. Entities involved with implementing project components are the Underwood Conservation District (UCD), USDA Forest Service (USFS), U.S. Geological Survey - Columbia River Research Lab (USGS-CRRL), and WA Department of Fish & Wildlife (WDFW).

  3. Summary report of Japan-US joint project. JUPITER-II. FuY 2001 - 2006

    International Nuclear Information System (INIS)

    Abe, K.; Kohyama, A.; Tanaka, S.; Muroga, T.; Namba, C.; Sze, D.K.

    2008-03-01

    This report summarizes the scientific accomplishments achieved through the JUPITER-II Japan-US Collaboration Program. The JUPITER-II collaboration (Japan-USA Program of Irradiation/Integration Test for Fusion Research -II) has been carried out through six years (2001-2006) under Phase 4 of the collaboration implemented by Amendment 4 of Annex I to the MEXT (Ministry of Education, Culture, Sports, Science and Technology)-DOE (United States Department of Energy) Cooperation. This program followed the RTNS-II Program (Phase 1: 1982-1986), the FFTF/MOTA Program (Phase 2: 1987-1994) and the JUPITER Program (Phase 3: 1995-2000). The JUPITER-II collaboration was established to provide the scientific foundations for understanding the integrated behavior of blanket materials combinations operating under conditions characteristic of fusion reactors, including interactive neutron irradiation effects, high temperature coolant flow phenomena, heat and mass transport in blanket materials, and coolant chemistry and its interactions with surrounding materials. The scientific concept of this program is to study the key technology in macroscopic system integration for advanced blanket based on an understanding of the relevant mechanics at the microscopic level. The 44 of the presented papers are indexed individually. (J.P.N.)

  4. Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization.

    Science.gov (United States)

    Shah, O Jameel; Lin, Xiaoyu; Li, Leiming; Huang, Xiaoli; Li, Junling; Anderson, Mark G; Tang, Hua; Rodriguez, Luis E; Warder, Scott E; McLoughlin, Shaun; Chen, Jun; Palma, Joann; Glaser, Keith B; Donawho, Cherrie K; Fesik, Stephen W; Shen, Yu

    2010-07-13

    Aurora kinase B inhibitors induce apoptosis secondary to polyploidization and have entered clinical trials as an emerging class of neocytotoxic chemotherapeutics. We demonstrate here that polyploidization neutralizes Mcl-1 function, rendering cancer cells exquisitely dependent on Bcl-XL/-2. This "addiction" can be exploited therapeutically by combining aurora kinase inhibitors and the orally bioavailable BH3 mimetic, ABT-263, which inhibits Bcl-XL, Bcl-2, and Bcl-w. The combination of ABT-263 with aurora B inhibitors produces a synergistic loss of viability in a range of cell lines of divergent tumor origin and exhibits more sustained tumor growth inhibition in vivo compared with aurora B inhibitor monotherapy. These data demonstrate that Bcl-XL/-2 is necessary to support viability during polyploidization in a variety of tumor models and represents a druggable molecular vulnerability with potential therapeutic utility.

  5. PREPARATION AIDS FOR THE DEVELOPMENT OF CATEGORY II QUALITY ASSURANCE PROJECT PLANS

    Science.gov (United States)

    Data collection activities performed for the Risk Reduction Engineering aboratory (RREL) of the U.S. Environmental Protection Agency are divided into tour categories, depending on the intended use of the data. uality Assurance (QA) Project Plans are written to ensure that project...

  6. Technical Assistance in Evaluating Career Education Projects. Final Report. Volume II: Final Career Education Evaluation Report.

    Science.gov (United States)

    Stenner, A. Jackson; And Others

    This document contains the second of five volumes reporting the activities and results of a career education evaluation project conducted to accomplish the following two objectives: (1) to improve the quality of evaluations by career education projects funded by the United States Office of Career Education (OCE) through the provision of technical…

  7. E region neutral winds in the postmidnight diffuse aurora during the atmospheric response in aurora 1 rocket campaign

    International Nuclear Information System (INIS)

    Brinkman, D.G.; Walterscheid, R.L.; Lyons, L.R.

    1995-01-01

    Measured E region neutral winds from the Atmospheric Response in Aurora (ARIA 1) rocket campaign are compared with winds predicted by a high-resolution nonhydrostatic dynamical thermosphere model. The ARIA 1 rockets were launched into the postmidnight diffuse aurora during the recovery phase of a substorm. Simulations have shown that electrodynamical coupling between the auroral ionosphere and the thermosphere was expected to be strong during active diffuse auroral conditions. This is the first time that simulations using the time history of detailed specifications of the magnitude and latitudinal variation of the auroral forcing based on measurements have been compared to simultaneous wind measurements. Model inputs included electron densities derived from ground-based airglow measurements, precipitating electron fluxes measured by the rocket, electron densities measured on the rocket, electric fields derived from magnetometer and satellite ion drift measurements, and large-scale background winds from a thermospheric general circulation model. Our model predicted a strong jet of eastward winds at E region heights. A comparison between model predicted and observed winds showed modest agreement. Above 135 km the model predicted zonal winds with the correct sense, the correct profile shape, and the correct altitude of the peak wind. However, it overpredicted the magnitude of the eastward winds by more than a factor or 2. For the meridional winds the model predicted the general sense of the winds but was unable to predict the structure or strength of the winds seen in the observations. Uncertainties in the magnitude and latitudinal structure of the electric field and in the magnitude of the background winds are the most likely sources of error contributing to the differences between model and observed winds. Between 110 and 135 km the agreement between the model and observations was poor because of a large unmodeled jetlike feature in the observed winds

  8. Atmospheric response in aurora experiment: Observations of E and F region neutral winds in a region of postmidnight diffuse aurora

    International Nuclear Information System (INIS)

    Larsen, M.F.; Marshall, T.R.; Mikkelsen, I.S.

    1995-01-01

    The goal of the Atmospheric Response in Aurora (ARIA) experiment carried out at Poker Flat, Alaska, on March 3, 1992, was to determine the response of the neutral atmosphere to the long-lived, large-scale forcing that is characteristic of the diffuse aurora in the postmidnight sector. A combination of chemical release rocket wind measurements, intrumented rocket composition measurements, and ground-based optical measurements were used to characterize the response of the neutral atmosphere. The rocket measurements were made at the end of a 90-min period of strong Joule heating. We focus on the neutral wind measurements made with the rocket. The forcing was determined by running the assimilated mapping of ionospheric electrodynamics (AMIE) analysis procedure developed at the National Center for Atmospheric Research. The winds expected at the latitude and longitude of the experiment were calculated using the spectral thermospheric general circulation model developed at the Danish Meteorological Institute. Comparisons of the observations and the model suggest that the neutral winds responded strongly in two height ranges. An eastward wind perturbation of ∼100 m s -1 developed between 140 and 200 km altitude with a peak near 160 km. A southwestward wind with peak magnitude of ∼150 m s -1 developed near 115 km altitude. The large amplitude winds at the lower altitude are particularly surprising. They appear to be associated with the upward propagating semidiurnal tide. However, the amplitude is much larger than predicted by any of the tidal models, and the shear found just below the peak in the winds was nomially unstable with a Richardson number of ∼0.08. 17 refs., 12 figs

  9. Detection of aurorae in light time of the day at rocket investigations of atmospheric radiation

    International Nuclear Information System (INIS)

    Khokhlov, V.N.

    1996-01-01

    Results of rocket observations of aurorae in light time of the day were analyzed. Characteristic features of Rayleigh scattering, day airglow, solar radiation, scattered in the device and near-rocket glow were considered. The contribution of aurorae in the light time of the day was determined on the basis of analyzing results of rocket experiments, laboratory measurements and theoretical simulation. 4 refs., 2 figs

  10. Aurorae between miracle and reality. History of culture and physics of a celestial phenomenon

    International Nuclear Information System (INIS)

    Schlegel, Birgit; Schlegel, Kristian

    2011-01-01

    Since the 18th century natural-researchers have searched for the natural-scientific explanations for the generation of aurorae, but just in ther 20th century the puzzle was completely solved. Facts from physics, geophysics, and space research, which are in connection with the generation of aurorae, are scientifically precisely explained in a generally understandable text up to the latest researches. Numerous pictures, photos, graphics, text extracts, as well as statements on the literature and on internet pages supplement the text.

  11. Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis

    OpenAIRE

    En-Ju Chou; Liang-Yi Hung; Chieh-Ju C. Tang; Wen-Bin Hsu; Hsin-Yi Wu; Pao-Chi Liao; Tang K. Tang

    2016-01-01

    CPAP is required for centriole elongation during S/G2 phase, but the role of CPAP in mitosis is incompletely understood. Here, we show that CPAP maintains spindle pole integrity through its phosphorylation by Aurora-A during mitosis. Depletion of CPAP induced a prolonged delay in mitosis, pericentriolar material (PCM) dispersion, and multiple mitotic abnormalities. Further studies demonstrated that CPAP directly interacts with and is phosphorylated by Aurora-A at serine 467 during mitosis. In...

  12. The evening diffuse radio aurora, field-aligned currents and particle precipitation

    International Nuclear Information System (INIS)

    Unwin, R.S.

    1980-01-01

    The relationship of the afternoon/evening diffuse radio aurora, proton and electron precipitation and field-aligned currents is studied with data from the auroral radar at Slope Point, New Zealand, and the ISIS 2 satellite. It is shown that there is a very close association between the radio aurora and (primarily downward) field-aligned currents, which confirms and extends previous work, but that there is no clear relation with either proton or electron precipitation. (author)

  13. Horonobe Underground Research Laboratory project. Plans of investigations during shaft and drift excavation (Construction of underground facilities: Phase II)

    International Nuclear Information System (INIS)

    2005-06-01

    Horonobe Underground Research Laboratory Project is planned for over 20 years to establish the scientific and technical basis for the underground disposal of high-level radioactive wastes in Japan. The investigations are conducted by JNC in three phases, from the surface (Phase I), during the construction of the underground facilities (Phase II), and using the facilities (Phase III). This report concerns the investigation plans for Phase II. During excavation of shafts and drifts, detailed geological and borehole investigation will be conducted and the geological model constructed in Phase I is evaluated and revised by newly acquired data of geophysical and geological environment. Detailed in-situ experiments, as well as the effects of shaft excavation, are also done to study long-term changes, rock properties, groundwater flow and chemistry to ensure the reliability of repository technology and establish safety assessment methodology. (S. Ohno)

  14. Gaseous time projection chambers for rare event detection: results from the T-REX project. II. Dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Irastorza, I.G.; Aznar, F.; Castel, J., E-mail: igor.irastorza@cern.ch, E-mail: faznar@unizar.es, E-mail: jfcastel@unizar.es [Grupo de Física Nuclear y Astropartículas, Departamento de Física Teórica, Universidad de Zaragoza, C/ P. Cerbuna 12, Zaragoza, 50009 Spain (Spain); and others

    2016-01-01

    As part of the T-REX project, a number of R and D and prototyping activities have been carried out during the last years to explore the applicability of gaseous Time Projection Chambers (TPCs) with Micromesh Gas Structures (Micromegas) in rare event searches like double beta decay, axion research and low-mass WIMP searches. While in the companion paper we focus on double beta decay, in this paper we focus on the results regarding the search for dark matter candidates, both axions and WIMPs. Small (few cm wide) ultra-low background Micromegas detectors are used to image the axion-induced x-ray signal expected in axion helioscopes like the CERN Axion Solar Telescope (CAST) experiment. Background levels as low as 0.8 × 10{sup −6} counts keV{sup −1} cm{sup −2} s{sup −1} have already been achieved in CAST while values down to ∼10{sup −7} counts keV{sup −1} cm{sup −2} s{sup −1} have been obtained in a test bench placed underground in the Laboratorio Subterráneo de Canfranc (LSC). Prospects to consolidate and further reduce these values down to ∼10{sup −8} counts keV{sup −1} cm{sup −2} s{sup −1} will be described. Such detectors, placed at the focal point of x-ray telescopes in the future International Axion Observatory (IAXO), would allow for 10{sup 5} better signal-to-noise ratio than CAST, and search for solar axions with g{sub a}γ down to few 10{sup 12} GeV{sup −1}, well into unexplored axion parameter space. In addition, a scaled-up version of these TPCs, properly shielded and placed underground, can be competitive in the search for low-mass WIMPs. The TREX-DM prototype, with ∼ 0.300 kg of Ar at 10 bar, or alternatively ∼ 0.160 kg of Ne at 10 bar, and energy threshold well below 1 keV, has been built to test this concept. We will describe the main technical solutions developed, as well as the results from the commissioning phase on surface. The anticipated sensitivity of this technique might reach ∼10{sup −44} cm{sup 2} for

  15. Historical space weather monitoring of prolonged aurora activities in Japan and in China

    Science.gov (United States)

    Kataoka, Ryuho; Isobe, Hiroaki; Hayakawa, Hisashi; Tamazawa, Harufumi; Kawamura, Akito Davis; Miyahara, Hiroko; Iwahashi, Kiyomi; Yamamoto, Kazuaki; Takei, Masako; Terashima, Tsuneyo; Suzuki, Hidehiko; Fujiwara, Yasunori; Nakamura, Takuji

    2017-02-01

    Great magnetic storms are recorded as aurora sightings in historical documents. The earliest known example of "prolonged" aurora sightings, with aurora persistent for two or more nights within a 7 day interval at low latitudes, in Japan was documented on 21-23 February 1204 in Meigetsuki, when a big sunspot was also recorded in China. We have searched for prolonged events over the 600 year interval since 620 in Japan based on the catalogue of Kanda and over the 700 year interval since 581 in China based on the catalogues of Tamazawa et al. (2017) and Hayakawa et al. (2015). Before the Meigetsuki event, a significant fraction of the 200 possible aurora sightings in Sòng dynasty (960-1279) of China was detected at least twice within a 7 day interval and sometimes recurred with approximately the solar rotation period of 27 days. The majority of prolonged aurora activity events occurred around the maximum phase of solar cycles rather than around the minimum, as estimated from the 14C analysis of tree rings. They were not reported during the Oort Minimum (1010-1050). We hypothesize that the prolonged aurora sightings are associated with great magnetic storms resulting from multiple coronal mass ejections from the same active region. The historical documents therefore provide useful information to support estimation of great magnetic storm frequency, which are often associated with power outages and other societal concerns.

  16. Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP.

    Science.gov (United States)

    Sarkar, Sukumar; Brautigan, David L; Larner, James M

    2017-08-01

    Reducing the levels of the androgen receptor (AR) is one of the most viable approaches to combat castration-resistant prostate cancer. Previously, we observed that proteasomal-dependent degradation of AR in response to 2-methoxyestradiol (2-ME) depends primarily on the E3 ligase C-terminus of HSP70-interacting protein (STUB1/CHIP). Here, 2-ME stimulation activates CHIP by phosphorylation via Aurora kinase A (AURKA). Aurora A kinase inhibitors and RNAi knockdown of Aurora A transcript selectively blocked CHIP phosphorylation and AR degradation. Aurora A kinase is activated by 2-ME in the S-phase as well as during mitosis, and phosphorylates CHIP at S273. Prostate cancer cells expressing an S273A mutant of CHIP have attenuated AR degradation upon 2-ME treatment compared with cells expressing wild-type CHIP, supporting the idea that CHIP phosphorylation by Aurora A activates its E3 ligase activity for the AR. These results reveal a novel 2-ME→Aurora A→CHIP→AR pathway that promotes AR degradation via the proteasome that may offer novel therapeutic opportunities for prostate cancer. Mol Cancer Res; 15(8); 1063-72. ©2017 AACR . ©2017 American Association for Cancer Research.

  17. Linux toys II 9 Cool New Projects for Home, Office, and Entertainment

    CERN Document Server

    Negus, Christopher

    2006-01-01

    Builds on the success of the original Linux Toys (0-7645-2508-5) and adds projects using different Linux distributionsAll-new toys in this edition include a car computer system with built-in entertainment and navigation features, bootable movies, a home surveillance monitor, a LEGO Mindstorms robot, and a weather mapping stationIntroduces small business opportunities with an Internet radio station and Internet caf ̌projectsCompanion Web site features specialized hardware drivers, software interfaces, music and game software, project descriptions, and discussion forumsIncludes a CD-ROM with scr

  18. UCH-II, private power project, Dera Murad Jamali, Pakistan. Export trade information

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-01

    Energy Resources International and Power Development Company of Pakistan in association with General Electric Corporation, Inc. offers to build, finance, own and operate a 500+ MW combined cycle natural gas electric power plant, near Dera Murad Jamali, Pakistan. The basis for the undertaking is a carefully balanced and integrated series of contracts for fuel, power purchase, and implementation of the proposed project. The contracts would be established between the Government of Pakistan (GOP), its agencies and instrumentalities, Energy Resources International with Power Development Company and its associates, and a Project Company organized specifically for the undertaking. The report describes the project.

  19. Report on evaluation for SRC-2 coal liquefaction project; SRC-II sekitan ekika project hyoka sagyo hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1979-10-01

    Among the EDS, H-Coal and SRC-2 lined up in the coal liquefaction project of the U.S., the SRC is aimed at producing 6,000 t/day as a module for a 30,000 t/day commercial plant. They expect Ash contents (iron, sulfur, etc.) in coal without basically using catalysts. The products are applicable to fuels for electricity and gas for the moment. In the element technology, there are some problems in manufacturing hydrogen by gasification of residuals as well as in slurry systems, reaction towers, etc.. In the 30,000 ton commercial plant, the coal-liquefied oil costs $19.89/bbl (price as of 1978) assuming coal costs $29.47; therefore, the feasibility is strong as a substitute for petroleum. Japan's share for the required funds will be 86.8 billion yen (if 250 yen per dollar). Since the kinds of coal are conceivably increased in number through the improvement of the process, the Pacific rim countries and these which lie on the Indian Ocean are assumed to be the major coal producing countries for Japan. The stability in storage of coal-liquefied oil is experimentally excellent, as is the compatibility with petroleum products for example. Great results can be expected in the technical know-how and the spread of element technology for Japan. (NEDO)

  20. Kac's question, planar isospectral pairs and involutions in projective space: II. Classification of generalized projective isospectral data

    International Nuclear Information System (INIS)

    Thas, Koen

    2006-01-01

    In Am. Math. Monthly (73 1-23 (1966)), Kac asked his famous question 'Can one hear the shape of a drum?', which was eventually answered negatively in Gordon et al (1992 Invent. Math. 110 1-22) by construction of planar isospectral pairs. Giraud (2005 J. Phys. A: Math. Gen. 38 L477-83) observed that most of the known examples can be generated from solutions of a certain equation which involves a set of involutions of an n-dimensional projective space over some finite field. He then generated all possible solutions for n = 2, when the involutions fix the same number of points. In Thas (2006 J. Phys. A: Math. Gen. 39 L385-8) we showed that no other examples arise for any other dimension, still assuming that the involutions fix the same number of points. In this paper we study the problem for involutions not necessarily fixing the same number of points, and solve the problem completely

  1. Report on evaluation for SRC-2 coal liquefaction project; SRC-II sekitan ekika project hyoka sagyo hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1979-10-01

    Among the EDS, H-Coal and SRC-2 lined up in the coal liquefaction project of the U.S., the SRC is aimed at producing 6,000 t/day as a module for a 30,000 t/day commercial plant. They expect Ash contents (iron, sulfur, etc.) in coal without basically using catalysts. The products are applicable to fuels for electricity and gas for the moment. In the element technology, there are some problems in manufacturing hydrogen by gasification of residuals as well as in slurry systems, reaction towers, etc.. In the 30,000 ton commercial plant, the coal-liquefied oil costs $19.89/bbl (price as of 1978) assuming coal costs $29.47; therefore, the feasibility is strong as a substitute for petroleum. Japan's share for the required funds will be 86.8 billion yen (if 250 yen per dollar). Since the kinds of coal are conceivably increased in number through the improvement of the process, the Pacific rim countries and these which lie on the Indian Ocean are assumed to be the major coal producing countries for Japan. The stability in storage of coal-liquefied oil is experimentally excellent, as is the compatibility with petroleum products for example. Great results can be expected in the technical know-how and the spread of element technology for Japan. (NEDO)

  2. Theme II Joint Work Plan -2017 Collaboration and Knowledge Sharing on Large-scale Demonstration Projects

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xiaoliang [World Resources Inst. (WRI), Washington, DC (United States); Stauffer, Philip H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-09-25

    This effort is designed to expedite learnings from existing and planned large demonstration projects and their associated research through effective knowledge sharing among participants in the US and China.

  3. Interconnection of Broadband Islands via Satellite-Experiments on the Race II Catalyst Project

    National Research Council Canada - National Science Library

    Sun, Z

    1996-01-01

    .... The purpose of the project was to develop an ATM satellite link for the future B-ISDN services, particularly for the interconnections of the ATM testbeds which are in the form of broadband islands...

  4. High temperature gasification and gas cleaning – phase II of the HotVegas project

    OpenAIRE

    Meysel, P.; Halama, S.; Botteghi, F.; Steibel, M.; Nakonz, M.; Rück, R.; Kurowski, P.; Buttler, A.; Spliethoff, H.

    2016-01-01

    The primary objective of the research project HotVeGas is to lay the necessary foundations for the long-term development of future, highly efficient high-temperature gasification processes. This includes integrated hot gas cleaning and optional CO2 capture and storage for next generation IGCC power plants and processes for the development of synthetic fuels. The joint research project is funded by the German Federal Ministry of Economics and Technology and five industry partners. It is coordi...

  5. Committee Report of the BEPC-II Project Design Review May 13-15, 2002, SLAC

    Energy Technology Data Exchange (ETDEWEB)

    Kawakami, Traci M.

    2002-08-26

    As part of the US-China Cooperative Program in High Energy Physics for the year 2002, a BEPC-II Upgrade Review meeting was held at SLAC, May 13-15, 2002. The upgrade is aimed at improving the luminosity and performance of the BEPC facility at IHEP in Beijing, China with major upgrades to the injector linac, storage ring, and detector. This review addresses mainly the accelerator related issues. Prior to the review, an updated Draft Design Report was made available to the review team. Most important technical change since April 2001 has been a change from a single-ring configuration to a doublering. The goal of the review is to determine whether BEPC-II, if built as described, will meet the operations and physics goals. The charge to the review team is attached as Appendix A.

  6. FRM-II project status and safety of its compact fuel element

    International Nuclear Information System (INIS)

    Nuding, M.; Rottmann, M.; Axmann, A.; Boening, K.

    2000-01-01

    The construction of the new research reactor FRM-II is close to completion and the nuclear start-up is scheduled to begin in January 2001. This contribution provides an overview on the concept of the facility and the safety features of the reactor. It also describes some of the tests performed during the licensing procedure of the compact fuel element and their results. At the end a short status report is given. (author)

  7. FRM-II project status and safety of its compact fuel element

    Energy Technology Data Exchange (ETDEWEB)

    Nuding, M.; Rottmann, M.; Axmann, A.; Boening, K. [Technical University of Munich, D-85747 Garching (Germany)

    2000-07-01

    The construction of the new research reactor FRM-II is close to completion and the nuclear start-up is scheduled to begin in January 2001. This contribution provides an overview on the concept of the facility and the safety features of the reactor. It also describes some of the tests performed during the licensing procedure of the compact fuel element and their results. At the end a short status report is given. (author)

  8. Technical Design Report for the FACET-II Project at SLAC National Accelerator Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2016-08-26

    Electrons can “surf” on waves of plasma – a hot gas of charged particles – gaining very high energies in very short distances. This approach, called plasma wakefield acceleration, has the potential to dramatically shrink the size and cost of particle accelerators. Research at the SLAC National Accelerator Laboratory has demonstrated that plasmas can provide 1,000 times the acceleration in a given distance compared with current technologies. Developing revolutionary and more efficient acceleration techniques that allow for an affordable high-energy collider has been the focus of FACET, a National User Facility at SLAC. FACET used part of SLAC’s two-mile-long linear accelerator to generate high-density beams of electrons and their antimatter counterparts, positrons. Research into plasma wakefield acceleration was the primary motivation for constructing FACET. In April 2016, FACET operations came to an end to make way for the second phase of SLAC’s x-ray laser, the LCLS-II, which will use part of the tunnel occupied by FACET. FACET-II is a new test facility to provide the unique capability to develop advanced acceleration and coherent radiation techniques with high-energy electron and positron beams. FACET-II represents a major upgrade over current FACET capabilities and the breadth of the potential research program makes it truly unique.

  9. Imprints of local lightcone \\ projection effects on the galaxy bispectrum. Part II

    Energy Technology Data Exchange (ETDEWEB)

    Jolicoeur, Sheean; Umeh, Obinna; Maartens, Roy; Clarkson, Chris, E-mail: beautifulheart369@gmail.com, E-mail: umeobinna@gmail.com, E-mail: roy.maartens@gmail.com, E-mail: chris.clarkson@qmul.ac.uk [Department of Physics and Astronomy, University of the Western Cape, Cape Town 7535 (South Africa)

    2017-09-01

    General relativistic imprints on the galaxy bispectrum arise from observational (or projection) effects. The lightcone projection effects include local contributions from Doppler and gravitational potential terms, as well as lensing and other integrated contributions. We recently presented for the first time, the correction to the galaxy bispectrum from all local lightcone projection effects up to second order in perturbations. Here we provide the details underlying this correction, together with further results and illustrations. For moderately squeezed shapes, the correction to the Newtonian prediction is ∼ 30% on equality scales at z ∼ 1. We generalise our recent results to include the contribution, up to second order, of magnification bias (which affects some of the local terms) and evolution bias.

  10. Indomethacin promotes apoptosis in gastric cancer cells through concomitant degradation of Survivin and Aurora B kinase proteins.

    Science.gov (United States)

    Chiou, Shiun-Kwei; Hoa, Neil; Hodges, Amy; Ge, Lishen; Jadus, Martin R

    2014-09-01

    Regular usage of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with reduced incidence of a variety of cancers. The molecular mechanisms underlying these chemopreventive effects remain poorly understood. This current investigation showed that in gastric cancer cells: (1) Indomethacin treatment enhanced the degradation of chromosomal passenger proteins, Survivin and Aurora B kinase; (2) Indomethacin treatment down-regulated Aurora B kinase activity in a cell cycle-independent fashion; (3) siRNA knockdown of Survivin level promoted Aurora B kinase protein degradation, and vice versa; (4) ectopic overexpression of Survivin blocked reduction of Aurora B kinase level and activity by indomethacin treatment, and vice versa; (5) siRNA knockdown of Aurora B kinase level and AZD1152 inhibition of its activity induced apoptosis, and overexpression of Aurora B kinase inhibited indomethacin-induced apoptosis; (6) indomethacin treatment reduced Aurora B kinase level, coinciding with reduction of Survivin level and induction of apoptosis, in KATO III and HT-29 cells, and in mouse gastric mucosa. A role for Aurora B kinase function in NSAID-induced apoptosis was not previously explored. Thus this report provides better understanding of the molecular mechanisms underlying the anti-cancer effect of NSAIDs by elucidating a significant role for Aurora B kinase in indomethacin-induced apoptosis.

  11. Equilibrium II: Acids and Bases. Independent Learning Project for Advanced Chemistry (ILPAC). Unit P3.

    Science.gov (United States)

    Inner London Education Authority (England).

    This unit on equilibrium is one of 10 first year units produced by the Independent Learning Project for Advanced Chemistry (ILPAC). The unit, which consists of two levels, focuses on the application of equilibrium principles to equilibria involving weak acids and bases, including buffer solutions and indicators. Level one uses Le Chatelier's…

  12. Individualized In-Service Teacher Education. (Project IN-STEP). Evaluation Report, Phase II.

    Science.gov (United States)

    Thurber, John C.

    Phase 2 of Project IN-STEP was conducted to revise, refine, and conduct further field testing of a new inservice teacher education model. The method developed (in Phase 1--see ED 003 905 for report) is an individualized, multi-media approach. Revision activities, based on feedback provided for Phase 1, include the remaking of six videotape…

  13. Description of the default climate scenario for impact projects in NRP-II

    NARCIS (Netherlands)

    Verweij W; Viner D; NOP

    2001-01-01

    The Dutch National Research Programme on Climate Change (NRP) is funding strategic research on climate change. One of the central research themes focuses on potential impacts of climate change. In general, results of impact projects may differ markedly, depending on input of scenario data for

  14. Vocational Assessment of Special Needs Individuals Project: Final Report. Phase II.

    Science.gov (United States)

    Stodden, Robert A.

    The Vocational Assessment of Special Needs Individuals Project originated with the regional vocational schools and educational collaboratives of the Assabet and Blackstone Valleys cooperating to determine a meaningful process through which vocational assessment information could be collected, organized, and used in formulating a basis for…

  15. Indianapolis Manpower Utilization Project of Flanner House. Phase II (February 1, 1968-April 30, 1968).

    Science.gov (United States)

    Flanner House, Inc., Indianapolis, IN.

    A private agency, Flanner House of Indianapolis, combined efforts with the Federal government, the Indiana State Employment Service, and private industry to provide upward job mobility for undereducated individuals who are either unemployed or underemployed. The project was designed to show that: (1) Private industry is willing to finance an…

  16. The AquaDEB project: Physiological flexibility of aquatic animals analysed with a generic dynamic energy budget model (phase II)

    Science.gov (United States)

    Alunno-Bruscia, Marianne; van der Veer, Henk W.; Kooijman, Sebastiaan A. L. M.

    2011-11-01

    This second special issue of the Journal of Sea Research on development and applications of Dynamic Energy Budget (DEB) theory concludes the European Research Project AquaDEB (2007-2011). In this introductory paper we summarise the progress made during the running time of this 5 years' project, present context for the papers in this volume and discuss future directions. The main scientific objectives in AquaDEB were (i) to study and compare the sensitivity of aquatic species (mainly molluscs and fish) to environmental variability within the context of DEB theory for metabolic organisation, and (ii) to evaluate the inter-relationships between different biological levels (individual, population, ecosystem) and temporal scales (life cycle, population dynamics, evolution). AquaDEB phase I focussed on quantifying bio-energetic processes of various aquatic species ( e.g. molluscs, fish, crustaceans, algae) and phase II on: (i) comparing of energetic and physiological strategies among species through the DEB parameter values and identifying the factors responsible for any differences in bioenergetics and physiology; (ii) considering different scenarios of environmental disruption (excess of nutrients, diffuse or massive pollution, exploitation by man, climate change) to forecast effects on growth, reproduction and survival of key species; (iii) scaling up the models for a few species from the individual level up to the level of evolutionary processes. Apart from the three special issues in the Journal of Sea Research — including the DEBIB collaboration (see vol. 65 issue 2), a theme issue on DEB theory appeared in the Philosophical Transactions of the Royal Society B (vol 365, 2010); a large number of publications were produced; the third edition of the DEB book appeared (2010); open-source software was substantially expanded (over 1000 functions); a large open-source systematic collection of ecophysiological data and DEB parameters has been set up; and a series of DEB

  17. Distribution of positive ion species above a diffuse midnight aurora

    International Nuclear Information System (INIS)

    Moore, T.E.

    1978-01-01

    The origin of the hot plasma in the Earth's magnetosphere is still open to investigation. Mass composition is an indicator of source region, while the distribution functions bear the signatures of transport and energization processes. Only ions identified as H + and He ++ were detected, and the He ++ was statistically marginal. Coincident magnetic storms are likely to play a crucial role in populating the magnetosphere with energized ionospheric ions. The measured proton distribution was nearly isotropic over downcoming pitch angles at all energies and showed a depleted atmospheric source cone. The high-altitude proton energy distribution had a best fit temperature of 4.5 keV and a number density of 0.17 cm- 3 , corresponding to a peak intensity just over 10 5 cm -2 s -1 sr -1 keV -1 . Altitudinal variations are consistent with the theory of charge exchange of a time-steady incident proton population. Simultaneous electron measurements can be interpreted in terms of an incident electron distribution that is also thermal wih a similar number density but a temperature of 2.5 keV. Taken together, the ion and electron data are consistent with the model of diffuse auroras in which plasma convecting in from the magnetospheric tail precipitates due to strong pitch angle diffusion on auroral field lines linking the near Earth plasma sheet

  18. Amplified spontaneous emission measurements on the Aurora large aperture module

    International Nuclear Information System (INIS)

    Oertel, J.A.; Czuchlewski, S.J.; Leland, W.T.; Turner, T.P.

    1990-01-01

    The large aperture module (LAM) of the Aurora KrF laser can be used to address a number of issues that relate to the scaling of KrF amplifiers to larger ICF systems. Perhaps foremost among these are the possible effects of amplified spontaneous emission (ASE) on laser performance. To assess this problem a 3-D computer code has been developed to model these ASE effects. The code uses an iterative procedure to arrive at a self-consistent steady state solution to the 3-D distribution of coherent and incoherent fluxes within the amplifier. Two-pass energy extraction, wall reflectivity, and nonuniform excitation are included in the model. The authors previously reported the effects of ASE on the small signal gains measured in the 1- x 1- x 2-m 3 LAM. The code also makes quantitative predictions of the ASE that should be generated in the amplifier. This paper indicates the radiance expected for a medium of uniform gain in terms of the (g - ν)L product and the parameter g/a. The quantity (g - ν)L is the product of the net gain and the path length along the direction of observation. The present experiments compare values of ASE measured at various locations around the LAM with the code predictions. The impact of ASE on amplifier output, is also discussed

  19. Ezekiel and the Northern Lights: Biblical aurora seems plausible

    Science.gov (United States)

    Siscoe, George L.; Silverman, Samuel M.; Siebert, Keith D.

    Auroral specialists have suggested that in the Bible's Old Testament book of Ezekiel, the opening vision of a "storm cloud out of the north" depicts imagery inspired by a low-latitude auroral display [Link, 1967; Eather, 1980; Silverman, 1998]. Naturally, other interpretations have been suggested, including a true epiphany, a sandstorm, a thunderstorm, a tornado, a solar halo, a hallucination, and a UFO. Biblical scholars place the site of the Ezekiel's vision about 100 km south of Babylon near Nippur, latitude ˜32°, longitude ˜45°, and the date is within a year or two of 593 B.C., or about 2600 years ago.An auroral interpretation of the vision is subject to possible refutation due to several geophysical considerations. Can auroras be seen at Ezekiel's latitude? More important, can they reach a coronal stage of development, which is what the vision requires? Was the tilt of the dipole axis favorable? Was the general level of solar activity favorable? And finally, What effect does a larger dipole moment in Ezekiel's time have on the question? All but the last question could have been answered on the basis of geophysical data a decade ago or earlier.

  20. Aurora 7 the Mercury space flight of M. Scott Carpenter

    CERN Document Server

    Burgess, Colin

    2016-01-01

    TO A NATION enthralled by the heroic exploits of the Mercury astronauts, the launch of Lt. Cmdr. Scott Carpenter on NASA’s second orbital space flight was a renewed cause for pride, jubilation and celebration. Within hours, that excitement had given way to stunned disbelief and anxiety as shaken broadcasters began preparing the American public for the very real possibility that an American astronaut and his spacecraft may have been lost at sea. In fact, it had been a very close call. Completely out of fuel and forced to manually guide Aurora 7 through the frightening inferno of re-entry, Carpenter brought the Mercury spacecraft down to a safe splashdown in the ocean. In doing so, he controversially overshot the intended landing zone. Despite his efforts, Carpenter’s performance on the MA-7 mission was later derided by powerful figures within NASA. He would never fly into space again. Taking temporary leave of NASA, Carpenter participated in the U.S. Navy’s pioneering Sealab program. For a record 30 days...

  1. Aurora Kinase A Is Not Involved in CPEB1 Phosphorylation and cyclin B1 mRNA Polyadenylation during Meiotic Maturation of Porcine Oocytes

    Czech Academy of Sciences Publication Activity Database

    Komrsková, Pavla; Šušor, Andrej; Malík, Radek; Procházková, Barbora; Lišková, Lucie; Šupolíková, Jaroslava; Hladký, Štěpán; Kubelka, Michal

    2014-01-01

    Roč. 9, č. 7 (2014), e101222-e101222 E-ISSN 1932-6203 R&D Projects: GA ČR GAP502/10/0944; GA ČR GA13-12291S; GA ČR GAP502/12/2201 Institutional support: RVO:67985904 ; RVO:68378050 Keywords : Aurora Kinase A Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.234, year: 2014 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0101222

  2. ARPA-E Impacts: A Sampling of Project Outcomes, Volume II

    Energy Technology Data Exchange (ETDEWEB)

    Rohlfing, Eric [Dept. of Energy (DOE), Washington DC (United States). Advanced Research Projects Agency-Energy (ARPA-E)

    2017-02-27

    The Advanced Research Projects Agency-Energy (ARPA-E) is demonstrating that a collaborative model has the power to deliver real value. The Agency’s first compilation booklet of impact sheets, published in 2016, began to tell the story of how ARPA-E has already made an impact in just seven years—funding a diverse and sophisticated research portfolio on advanced energy technologies that enable the United States to tackle our most pressing energy challenges. One year later our research investments continue to pay off, with a number of current and alumni project teams successfully commercializing their technologies and advancing the state of the art in transformative areas of energy science and engineering. There is no single measure that can fully illustrate ARPA-E’s success to date, but several statistics viewed collectively begin to reveal the Agency’s impact. Since 2009, ARPA-E has provided more than $1.5 billion in funding for 36 focused programs and three open funding solicitations, totaling over 580 projects. Of those, 263 are now alumni projects. Many teams have successfully leveraged ARPA-E’s investment: 56 have formed new companies, 68 have partnered with other government agencies to continue their technology development, and 74 teams have together raised more than $1.8 billion in reported funding from the private sector to bring their technologies to market. However, even when viewed together, those measures do not capture ARPA-E’s full impact. To best understand the Agency’s success, the specific scientific and engineering challenges that ARPA-E project teams have overcome must be understood. This booklet provides concrete examples of those successes, ranging from innovations that will bear fruit in the future to ones that are beginning to penetrate the market as products today. Importantly, half of the projects highlighted in this volume stem from OPEN solicitations, which the agency has run in 2009, 2012, and 2015. ARPA-E’s OPEN programs

  3. Advanced conceptual design report. Phase II. Liquid effluent treatment and disposal Project W-252

    International Nuclear Information System (INIS)

    1995-01-01

    This Advanced Conceptual Design Report (ACDR) provides a documented review and analysis of the Conceptual Design Report (CDR), WHC-SD-W252-CDR-001, June 30, 1993. The ACDR provides further design evaluation of the major design approaches and uncertainties identified in the original CDR. The ACDR will provide a firmer basis for the both the design approach and the associated planning for the performance of the Definitive Design phase of the project

  4. A Dictionary of Basic Pashto Frequency List I, Project Description and Samples, and Frequency List II.

    Science.gov (United States)

    Heston, Wilma

    The three-volume set of materials describes and presents the results to date of a federally-funded project to develop Pashto-English and English-Pashto dictionaries. The goal was to produce a list of 12,000 basic Pashto words for English-speaking users. Words were selected based on frequency in various kinds of oral and written materials, and were…

  5. SKI SITE-94. Deep Repository Performance Assessment Project Volume I and II

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    The function of SITE-94 is to provide the Swedish Nuclear Power Inspectorate (SKI) with the capacity and supporting knowledge needed for reviewing the Swedish nuclear industry`s R and D programs and for reviewing license applications, as stipulated in Swedish legislation. The report is structured as a Performance Assessment exercise needed for input to decisions regarding repository safety, but the SITE-94 is not a safety assessment or a model for future assessments to be undertaken by the prospective licensee. The specific project objectives of SITE-94 comprise site evaluation, performance assessment methodology, canister integrity and radionuclide release and transport calculations. The report gives a detailed description of the many inter-related studies undertaken as part of the research project. As a general conclusion it is noted that the SITE-94 project has significantly advanced SKI`s capability of reviewing performance assessments and has led to the development of a tool-kit for carrying out assessment calculations, both in terms of numerical and scoping analyses. The study has highlighted a number of key issues for safety assessment (and consequently for disposal system design): Canister performance; Derived parameters of geosphere retention properties; Spatial variability of groundwater flow and geochemistry of migration paths; Time dependency (more emphasis on transient, time-dependent processes); Buffer evolution over long time. 488 refs.

  6. SKI SITE-94. Deep Repository Performance Assessment Project Volume I and II

    International Nuclear Information System (INIS)

    1996-12-01

    The function of SITE-94 is to provide the Swedish Nuclear Power Inspectorate (SKI) with the capacity and supporting knowledge needed for reviewing the Swedish nuclear industry's R and D programs and for reviewing license applications, as stipulated in Swedish legislation. The report is structured as a Performance Assessment exercise needed for input to decisions regarding repository safety, but the SITE-94 is not a safety assessment or a model for future assessments to be undertaken by the prospective licensee. The specific project objectives of SITE-94 comprise site evaluation, performance assessment methodology, canister integrity and radionuclide release and transport calculations. The report gives a detailed description of the many inter-related studies undertaken as part of the research project. As a general conclusion it is noted that the SITE-94 project has significantly advanced SKI's capability of reviewing performance assessments and has led to the development of a tool-kit for carrying out assessment calculations, both in terms of numerical and scoping analyses. The study has highlighted a number of key issues for safety assessment (and consequently for disposal system design): Canister performance; Derived parameters of geosphere retention properties; Spatial variability of groundwater flow and geochemistry of migration paths; Time dependency (more emphasis on transient, time-dependent processes); Buffer evolution over long time. 488 refs

  7. Farm Hall and the German atomic project of World War II a dramatic history

    CERN Document Server

    Cassidy, David C

    2017-01-01

    This gripping book brings back to life the events surrounding the internment of ten German Nuclear Scientists immediately after World War II. It is also an "eye-witness" account of the dawning of the nuclear age, with the dialogue and narrative spanning the period before, during and after atomic bombs were dropped on Japan at the end of the war. This pivotal historical episode is conveyed, along with the emotions as well as the facts, through drama, historical narrative, and photographs of the captive German nuclear scientists - who included Werner Heisenberg, Otto Hahn, and Max von Laue. The unique story that unfolds in the play is based on secretly recorded transcripts of the scientists’ actual conversations at Farm Hall, together with related documents and photographs.

  8. Syncrude's Aurora Mine : the key to future Athabasca oil sands development

    International Nuclear Information System (INIS)

    Kershaw, D.

    1998-01-01

    Syncrude's newest mine, the Aurora mine is located 35 km northeast of Syncrude's existing Mildred Lake plant, across the Athabasca River. It has a potential to produce more than 2.5 billion barrels of bitumen. Aurora will eventually consist of two surface mines, the Aurora North and Aurora South. Mining and extraction will occur at Aurora with the resulting bitumen transported as a froth by pipeline back to the existing plant for upgrading to Syncrude Sweet Blend. A total of 120 km of pipeline will be used. Syncrude has developed a new method of sending oilsand from its Athabasca deposit to the extraction plant. The company plans to phase out the dragline, bucketwheel reclaimer, and conveyor ore mining and delivery system in favour of shovel, truck, and hydrotransport technology. The advantages of hydrotransport include significant energy savings and considerably less plant infrastructure. A hydrotransport prototype is at work at Syncrude's base mine where it is responsible for 15 per cent of the production

  9. Summary of environmental impact assessment for the Syncrude Canada Ltd. Aurora Mine

    International Nuclear Information System (INIS)

    1996-01-01

    A summary of the environmental impact assessment for the Syncrude's proposed Aurora Mine was provided. Two mining areas will be opened. Aurora Mine North, located on oil sands leases 10, 12 and 34 will open first followed by the opening of Aurora Mine South, located on Lease 31. Each mining area will contain two extraction facilities, each capable of producing 6.25 million cubic metres of bitumen per year for a total annual capacity of 25 million cubic metres. The areas of land that will be disturbed by development of the Aurora Mines will total 15,171 hectares. The preferred pipeline, roadway and utility corridor and river crossing to be used for the Mine are shown. Production of SO 2 and NO x emissions from the Aurora Mine is expected to be very low, nevertheless, the cumulative effects of emissions from the mines will be addressed in the context of emissions from the existing or proposed oil sand facilities in the area. 7 tabs., 15 figs

  10. Rebamipide inhibits gastric cancer growth by targeting survivin and Aurora-B

    International Nuclear Information System (INIS)

    Tarnawski, A.; Pai, R.; Chiou, S.-K.; Chai, J.; Chu, E.C.

    2005-01-01

    Rebamipide accelerates healing of gastric ulcers and gastritis but its actions on gastric cancer are not known. Survivin, an anti-apoptosis protein, is overexpressed in stem, progenitor, and cancer cells. In gastric cancer, increased and sustained survivin expression provides survival advantage and facilitates tumor progression and resistance to anti-cancer drugs. Aurora-B kinase is essential for chromosome alignment and mitosis progression but surprisingly its role in gastric cancer has not been explored. We examined in human gastric cancer AGS cells: (1) survivin expression, (2) localization of survivin and Aurora-B (3) cell proliferation, and (4) effects of specific survivin siRNA and/or rebamipide (free radical scavenging drug) on survivin and Aurora-B expression and cell proliferation. Survivin and Aurora-B are strongly expressed in human AGS gastric cancer cells and co-localize during mitosis. Survivin siRNA significantly reduces AGS cell viability. Rebamipide significantly downregulates in AGS cell survivin expression, its association with Aurora-B and cell proliferation. Rebamipide-induced downregulation of survivin is at the transcription level and does not involve ubiquitin-proteasome pathway

  11. A relaxation-projection method for compressible flows. Part II: Artificial heat exchanges for multiphase shocks

    International Nuclear Information System (INIS)

    Petitpas, Fabien; Franquet, Erwin; Saurel, Richard; Le Metayer, Olivier

    2007-01-01

    The relaxation-projection method developed in Saurel et al. [R. Saurel, E. Franquet, E. Daniel, O. Le Metayer, A relaxation-projection method for compressible flows. Part I: The numerical equation of state for the Euler equations, J. Comput. Phys. (2007) 822-845] is extended to the non-conservative hyperbolic multiphase flow model of Kapila et al. [A.K. Kapila, Menikoff, J.B. Bdzil, S.F. Son, D.S. Stewart, Two-phase modeling of deflagration to detonation transition in granular materials: reduced equations, Physics of Fluids 13(10) (2001) 3002-3024]. This model has the ability to treat multi-temperatures mixtures evolving with a single pressure and velocity and is particularly interesting for the computation of interface problems with compressible materials as well as wave propagation in heterogeneous mixtures. The non-conservative character of this model poses however computational challenges in the presence of shocks. The first issue is related to the Riemann problem resolution that necessitates shock jump conditions. Thanks to the Rankine-Hugoniot relations proposed and validated in Saurel et al. [R. Saurel, O. Le Metayer, J. Massoni, S. Gavrilyuk, Shock jump conditions for multiphase mixtures with stiff mechanical relaxation, Shock Waves 16 (3) (2007) 209-232] exact and approximate 2-shocks Riemann solvers are derived. However, the Riemann solver is only a part of a numerical scheme and non-conservative variables pose extra difficulties for the projection or cell average of the solution. It is shown that conventional Godunov schemes are unable to converge to the exact solution for strong multiphase shocks. This is due to the incorrect partition of the energies or entropies in the cell averaged mixture. To circumvent this difficulty a specific Lagrangian scheme is developed. The correct partition of the energies is achieved by using an artificial heat exchange in the shock layer. With the help of an asymptotic analysis this heat exchange takes a similar form as

  12. {open_quotes}O{close_quotes} ring sealed process tube, Phase II, test project

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, R.E.

    1951-04-09

    The {open_quotes}O{close_quotes} ring seal has been proposed to replace the van stone flange and the bellows thermal expansion assembly currently used on the existing Hanford piles to achieve water and gas seals, respectively. Possible advantages of the {open_quotes}O{close_quotes} ring seal are: (1) simplification of component parts and elimination of van stone corrosion; (2) simplification of maintenance; (3) lower costs of initial erection; (4) increased strength. This test supplements Test Project No. 27 (a preliminary thermal cycling test) in applying the {open_quotes}O{close_quotes} ring seal assembly to actual pile operating conditions.

  13. A relaxation-projection method for compressible flows. Part II: Artificial heat exchanges for multiphase shocks

    Science.gov (United States)

    Petitpas, Fabien; Franquet, Erwin; Saurel, Richard; Le Metayer, Olivier

    2007-08-01

    The relaxation-projection method developed in Saurel et al. [R. Saurel, E. Franquet, E. Daniel, O. Le Metayer, A relaxation-projection method for compressible flows. Part I: The numerical equation of state for the Euler equations, J. Comput. Phys. (2007) 822-845] is extended to the non-conservative hyperbolic multiphase flow model of Kapila et al. [A.K. Kapila, Menikoff, J.B. Bdzil, S.F. Son, D.S. Stewart, Two-phase modeling of deflagration to detonation transition in granular materials: reduced equations, Physics of Fluids 13(10) (2001) 3002-3024]. This model has the ability to treat multi-temperatures mixtures evolving with a single pressure and velocity and is particularly interesting for the computation of interface problems with compressible materials as well as wave propagation in heterogeneous mixtures. The non-conservative character of this model poses however computational challenges in the presence of shocks. The first issue is related to the Riemann problem resolution that necessitates shock jump conditions. Thanks to the Rankine-Hugoniot relations proposed and validated in Saurel et al. [R. Saurel, O. Le Metayer, J. Massoni, S. Gavrilyuk, Shock jump conditions for multiphase mixtures with stiff mechanical relaxation, Shock Waves 16 (3) (2007) 209-232] exact and approximate 2-shocks Riemann solvers are derived. However, the Riemann solver is only a part of a numerical scheme and non-conservative variables pose extra difficulties for the projection or cell average of the solution. It is shown that conventional Godunov schemes are unable to converge to the exact solution for strong multiphase shocks. This is due to the incorrect partition of the energies or entropies in the cell averaged mixture. To circumvent this difficulty a specific Lagrangian scheme is developed. The correct partition of the energies is achieved by using an artificial heat exchange in the shock layer. With the help of an asymptotic analysis this heat exchange takes a similar form as

  14. First results of the Auroral Turbulance II rocket experiment

    DEFF Research Database (Denmark)

    Danielides, M.A.; Ranta, A.; Ivchenco, N.

    1999-01-01

    The Auroral Turbulance II sounding rocket was launched on February 11, 1997 into moderately active nightside aurora from the Poker Flat Research Range, Alaska, US. The experiment consisted of three independent, completely instrumented payloads launched by a single vehicle. The aim of the experiment...

  15. Urochordate ascidians possess a single isoform of Aurora kinase that localizes to the midbody via TPX2 in eggs and cleavage stage embryos.

    Directory of Open Access Journals (Sweden)

    Celine Hebras

    Full Text Available Aurora kinases are key proteins found throughout the eukaryotes that control mitotic progression. Vertebrate Aurora-A and B kinases are thought to have evolved from a single Aurora-kinase isoform closest to that found in present day urochordates. In urochordate ascidians Aurora binds both TPX2 (a vertebrate AURKA partner and INCENP (a vertebrate AURKB partner and localizes to centrosomes and spindle microtubules as well as chromosomes and midbody during both meiosis and mitosis. Ascidian Aurora also displays this localization pattern during mitosis in echinoderms, strengthening the idea that non-vertebrate deuterostomes such as the urochordates and echinoderms possess a single form of Aurora kinase that has properties of vertebrate Aurora-kinase A and B. In the ascidian, TPX2 localizes to the centrosome and the spindle poles also as in vertebrates. However, we were surprised to find that TPX2 also localized strongly to the midbody in ascidian eggs and embryos. We thus examined more closely Aurora localization to the midbody by creating two separate point mutations of ascidian Aurora predicted to perturb binding to TPX2. Both forms of mutated Aurora behaved as predicted: neither localized to spindle poles where TPX2 is enriched. Interestingly, neither form of mutated Aurora localized to the midbody where TPX2 is also enriched, suggesting that ascidian Aurora midbody localization required TPX2 binding in ascidians. Functional analysis revealed that inhibition of Aurora kinase with a pharmacological inhibitor or with a dominant negative kinase dead form of Aurora caused cytokinesis failure and perturbed midbody formation during polar body extrusion. Our data support the view that vertebrate Aurora-A and B kinases evolved from a single non-vertebrate deuterostome ancestor. Moreover, since TPX2 localizes to the midbody in ascidian eggs and cleavage stage embryos it may be worthwhile re-assessing whether Aurora A kinase or TPX2 localize to the midbody

  16. Technical realisation of the VISA-II project, phase I, part IV, IZ-165-o268-1962; Tehnicka realizacija projekta VISA-II, I faza (I-V), IV deo, IZ-165-o268-1962

    Energy Technology Data Exchange (ETDEWEB)

    Pavicevic, M [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1962-12-15

    Project VISA-II is described in IX chapters as follows: introduction, definition of experiments and possibilities of performance; VISA-II channel, new experimental space in the RA reactor; hydraulic tests in the VISA-II channel; measurement of fast neutron and gamma flux in VISA-II channels; measurement of water flow through different VISA-2 irradiation capsules; fabrication of VISA-II capsules; corrosion and heavy water purity problems; safety problems of experiment VISA-2; experimental operation of VISA-II. This chapter VI includes documentation for each type of capsule, review about each experiment within the VISA-II project, the objective and purpose of the experiment as well as experimental device. [Serbo-Croat] Projekat VISA-2 opisan je u sledecih IX poglavlja: uvod, definicija eksperimenta VISA-2 i mogucnost njegovog izvodjenja; kanal VISA-2 novi eksperimentalni prostor u reaktoru RA; hidraulicna ispitivanja na tehnoloskom kanalu VISA-2; Realizacija merenja fluksa brzih neutrona i gama zracenja u kanalima VISA-2; merenje protoka vode kroz razne tipove kapsula VISA-2; Kapsule VISA-2 i njihova realizacija; problemi korozije i cistoce teske vode u projektu VISA-2; problemi sigurnosti eksperimenta VISA-2; probni pogon eksperimenta VISA-2. Ova VI glava elaborata sadrzi dokumentaciju za svaku vrstu kapsula, preglednu sliku o svakom eksperimentu u okviru projekta VISA-2, o njegovom cilju i nameni kao i o eksperimentalnom uredjaju.

  17. Qinshan phase II extension nuclear power project thermal stratification and fatigue stress analysis for pressurizer surge line

    International Nuclear Information System (INIS)

    Yu Xiaofei; Zhang Yixiong; Ai Honglei

    2010-01-01

    Thermal stratification of pressurizer surge line induced by the inside fluid brings on global bending moments, local thermal stresses, unexpected displacements and support loadings of the pipe system. In order to avoid a costly three-dimensional computation, a combined 1D/2D technique has been developed and implemented to analyze the thermal stratification and fatigue stress of pressurize surge line of QINSHAN Phase II Extension Nuclear Power Project in this paper, using the computer codes SYSTUS and ROCOCO. According to the mechanical analysis results of stratification, the maximum stress and cumulative usage factor, the loadings at connections of surge line to main pipe and RCP and the displacements of surge line at supports are obtained. (authors)

  18. Tension-Induced Error Correction and Not Kinetochore Attachment Status Activates the SAC in an Aurora-B/C-Dependent Manner in Oocytes.

    Science.gov (United States)

    Vallot, Antoine; Leontiou, Ioanna; Cladière, Damien; El Yakoubi, Warif; Bolte, Susanne; Buffin, Eulalie; Wassmann, Katja

    2018-01-08

    Cell division with partitioning of the genetic material should take place only when paired chromosomes named bivalents (meiosis I) or sister chromatids (mitosis and meiosis II) are correctly attached to the bipolar spindle in a tension-generating manner. For this to happen, the spindle assembly checkpoint (SAC) checks whether unattached kinetochores are present, in which case anaphase onset is delayed to permit further establishment of attachments. Additionally, microtubules are stabilized when they are attached and under tension. In mitosis, attachments not under tension activate the so-named error correction pathway depending on Aurora B kinase substrate phosphorylation. This leads to microtubule detachments, which in turn activates the SAC [1-3]. Meiotic divisions in mammalian oocytes are highly error prone, with severe consequences for fertility and health of the offspring [4, 5]. Correct attachment of chromosomes in meiosis I leads to the generation of stretched bivalents, but-unlike mitosis-not to tension between sister kinetochores, which co-orient. Here, we set out to address whether reduction of tension applied by the spindle on bioriented bivalents activates error correction and, as a consequence, the SAC. Treatment of oocytes in late prometaphase I with Eg5 kinesin inhibitor affects spindle tension, but not attachments, as we show here using an optimized protocol for confocal imaging. After Eg5 inhibition, bivalents are correctly aligned but less stretched, and as a result, Aurora-B/C-dependent error correction with microtubule detachment takes place. This loss of attachments leads to SAC activation. Crucially, SAC activation itself does not require Aurora B/C kinase activity in oocytes. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Gulf of Mexico Gas Hydrate Joint Industry Project Leg II logging-while-drilling data acquisition and analysis

    Science.gov (United States)

    Collett, Timothy S.; Lee, Wyung W.; Zyrianova, Margarita V.; Mrozewski, Stefan A.; Guerin, Gilles; Cook, Ann E.; Goldberg, Dave S.

    2012-01-01

    One of the objectives of the Gulf of Mexico Gas Hydrate Joint Industry Project Leg II (GOM JIP Leg II) was the collection of a comprehensive suite of logging-while-drilling (LWD) data within gas-hydrate-bearing sand reservoirs in order to make accurate estimates of the concentration of gas hydrates under various geologic conditions and to understand the geologic controls on the occurrence of gas hydrate at each of the sites drilled during this expedition. The LWD sensors just above the drill bit provided important information on the nature of the sediments and the occurrence of gas hydrate. There has been significant advancements in the use of downhole well-logging tools to acquire detailed information on the occurrence of gas hydrate in nature: From using electrical resistivity and acoustic logs to identify gas hydrate occurrences in wells to where wireline and advanced logging-while-drilling tools are routinely used to examine the petrophysical nature of gas hydrate reservoirs and the distribution and concentration of gas hydrates within various complex reservoir systems. Recent integrated sediment coring and well-log studies have confirmed that electrical resistivity and acoustic velocity data can yield accurate gas hydrate saturations in sediment grain supported (isotropic) systems such as sand reservoirs, but more advanced log analysis models are required to characterize gas hydrate in fractured (anisotropic) reservoir systems. In support of the GOM JIP Leg II effort, well-log data montages have been compiled and presented in this report which includes downhole logs obtained from all seven wells drilled during this expedition with a focus on identifying and characterizing the potential gas-hydrate-bearing sedimentary section in each of the wells. Also presented and reviewed in this report are the gas-hydrate saturation and sediment porosity logs for each of the wells as calculated from available downhole well logs.

  20. Gulf of Mexico Gas Hydrate Joint Industry Project Leg II logging-while-drilling data acquisition and anaylsis

    Science.gov (United States)

    Collett, Timothy S.; Lee, Myung W.; Zyrianova, Margarita V.; Mrozewski, Stefan A.; Guerin, Gilles; Cook, Ann E.; Goldberg, Dave S.

    2012-01-01

    One of the objectives of the Gulf of MexicoGasHydrateJointIndustryProjectLegII (GOM JIP LegII) was the collection of a comprehensive suite of logging-while-drilling (LWD) data within gas-hydrate-bearing sand reservoirs in order to make accurate estimates of the concentration of gashydrates under various geologic conditions and to understand the geologic controls on the occurrence of gashydrate at each of the sites drilled during this expedition. The LWD sensors just above the drill bit provided important information on the nature of the sediments and the occurrence of gashydrate. There has been significant advancements in the use of downhole well-logging tools to acquire detailed information on the occurrence of gashydrate in nature: From using electrical resistivity and acoustic logs to identify gashydrate occurrences in wells to where wireline and advanced logging-while-drilling tools are routinely used to examine the petrophysical nature of gashydrate reservoirs and the distribution and concentration of gashydrates within various complex reservoir systems. Recent integrated sediment coring and well-log studies have confirmed that electrical resistivity and acoustic velocity data can yield accurate gashydrate saturations in sediment grain supported (isotropic) systems such as sand reservoirs, but more advanced log analysis models are required to characterize gashydrate in fractured (anisotropic) reservoir systems. In support of the GOM JIP LegII effort, well-log data montages have been compiled and presented in this report which includes downhole logs obtained from all seven wells drilled during this expedition with a focus on identifying and characterizing the potential gas-hydrate-bearing sedimentary section in each of the wells. Also presented and reviewed in this report are the gas-hydrate saturation and sediment porosity logs for each of the wells as calculated from available downhole well logs.

  1. River Protection Project Integrated safety management system phase II verification review plan - 7/29/99

    International Nuclear Information System (INIS)

    SHOOP, D.S.

    1999-01-01

    The purpose of this review is to verify the implementation status of the Integrated Safety Management System (ISMS) for the River Protection Project (RPP) facilities managed by Fluor Daniel Hanford, Inc. (FDH) and operated by Lockheed Martin Hanford Company (LMHC). This review will also ascertain whether within RPP facilities and operations the work planning and execution processes are in place and functioning to effectively protect the health and safety of the workers, public, environment, and federal property over the RPP life cycle. The RPP ISMS should support the Hanford Strategic Plan (DOERL-96-92) to safely clean up and manage the site's legacy waste and deploy science and technology while incorporating the ISMS central theme to ''Do work safely'' and protect human health and the environment

  2. Viscous and Aeroelastic Effects on Wind Turbine Blades. The VISCEL Project. Part II: Aeroelastic Stability Investigations

    Science.gov (United States)

    Chaviaropoulos, P. K.; Soerensen, N. N.; Hansen, M. O. L.; Nikolaou, I. G.; Aggelis, K. A.; Johansen, J.; Gaunaa, Mac; Hambraus, T.; Frhr. von Geyr, Heiko; Hirsch, Ch.; Shun, Kang; Voutsinas, S. G.; Tzabiras, G.; Perivolaris, Y.; Dyrmose, S. Z.

    2003-10-01

    The recent introduction of ever larger wind turbines poses new challenges with regard to understanding the mechanisms of unsteady flow-structure interaction. An important aspect of the problem is the aeroelastic stability of the wind turbine blades, especially in the case of combined flap/lead-lag vibrations in the stall regime. Given the limited experimental information available in this field, the use of CFD techniques and state-of-the-art viscous flow solvers provides an invaluable alternative towards the identification of the underlying physics and the development and validation of sound engineering-type aeroelastic models. Navier-Stokes-based aeroelastic stability analysis of individual blade sections subjected to combined pitch/flap or flap/lead-lag motion has been attempted by the present consortium in the framework of the concluded VISCEL JOR3-CT98-0208 Joule III project.

  3. Southwest Project: resource/institutional requirements analysis. Volume II. Technical studies

    Energy Technology Data Exchange (ETDEWEB)

    Ormsby, L. S.; Sawyer, T. G.; Brown, Dr., M. L.; Daviet, II, L. L.; Weber, E. R.; Brown, J. E.; Arlidge, J. W.; Novak, H. R.; Sanesi, Norman; Klaiman, H. C.; Spangenberg, Jr., D. T.; Groves, D. J.; Maddox, J. D.; Hayslip, R. M.; Ijams, G.; Lacy, R. G.; Montgomery, J.; Carito, J. A.; Ballance, J. W.; Bluemle, C. F.; Smith, D. N.; Wehrey, M. C.; Ladd, K. L.; Evans, Dr., S. K.; Guild, D. H.; Brodfeld, B.; Cleveland, J. A.; Hicks, K. L.; Noga, M. W.; Ross, A. M.

    1979-12-01

    The project provides information which could be used to accelerate the commercialization and market penetration of solar electric generation plants in the southwestern region of the United States. The area of concern includes Arizona, California, Colorado, Nevada, New Mexico, Utah, and sections of Oklahoma and Texas. The project evaluated the potential integration of solar electric generating facilities into the existing electric grids of the region through the year 2000. The technologies included wind energy conversion, solar thermal electric, solar photovoltaic conversion, and hybrid solar electric systems. Each of the technologies considered, except hybrid solar electric, was paired with a compatible energy storage system to improve plant performance and enhance applicability to a utility grid system. The hybrid concept utilizes a conventionally-fueled steam generator as well as a solar steam generator so it is not as dependent upon the availability of solar energy as are the other concepts. Operation of solar electric generating plants in conjunction with existing hydroelectric power facilities was also studied. The participants included 12 electric utility companies and a state power authority in the southwestern US, as well as a major consulting engineering firm. An assessment of the state-of-the-art of solar electric generating plants from an electric utility standpoint; identification of the electric utility industry's technical requirements and considerations for solar electric generating plants; estimation of the capital investment, operation, and maintenance costs for solar electric generating plants; and determination of the capital investment of conventional fossil and nuclear electric generating plants are presented. (MCW)

  4. Breckinridge Project, initial effort. Report VII, Volume II. Environmental baseline report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1982-01-01

    Ashland Synthetic Fuels, Inc. (ASFI) and Airco Energy Company, Inc. (AECI) have recently formed the Breckinridge Project and are currently conducting a process and economic feasibility study of a commercial scale facility to produce synthetic liquid fuels from coal. The coal conversion process to be used is the H-COAL process, which is in the pilot plant testing stage under the auspices of the US Department of Energy at the H-COAL Pilot Plant Project near Catlettsburg, Kentucky. The preliminary plans for the commercial plant are for a 18,140 metric ton/day (24,000 ton/day) nominal coal assumption capacity utilizing the abundant high sulfur Western Kentucky coals. The Western Kentucky area offers a source of the coal along with adequate water, power, labor, transportation and other factors critical to the successful siting of a plant. Various studies by federal and state governments, as well as private industry, have reached similar conclusions regarding the suitability of such plant sites in western Kentucky. Of the many individual sites evaluated, a site in Breckinridge County, Kentucky, approximately 4 kilometers (2.5 miles) west of the town of Stephensport, has been identified as the plant location. Actions have been taken to obtain options to insure that this site will be available when needed. This report contains an overview of the regional setting and results of the baseline environmental studies. These studies include collection of data on ambient air and water quality, sound, aquatic and terrestrial biology and geology. This report contains the following chapters; introduction, review of significant findings, ambient air quality monitoring, sound, aquatic ecology, vegetation, wildlife, geology, soils, surface water, and ground water.

  5. Morphology and dynamics of aurora at fine scale: first results from the ASK instrument

    Directory of Open Access Journals (Sweden)

    H. Dahlgren

    2008-05-01

    Full Text Available The ASK instrument (Auroral Structure and Kinetics is a narrow field auroral imager, providing simultaneous images of aurora in three different spectral bands at multiple frames per second resolution. The three emission species studied are O2+ (5620 Å, O+ (7319 Å and O (7774 Å. ASK was installed and operated for the first time in an observational campaign on Svalbard, from December 2005 to March 2006. The measurements were supported by data from the Spectrographic Imaging Facility (SIF. The relation between the morphology and dynamics of the visible aurora and its spectral characteristics is studied for selected events from this period. In these events it is found that dynamic aurora is coupled to high energy electron precipitation. By studying the O2+/O intensity ratio we find that some auroral filaments are caused by higher energy precipitation within regions of lower energy precipitation, whereas other filaments are the result of a higher particle flux compared to the surroundings.

  6. A search for supersymmetric electrons with the Mark II detector at PEP [Positron Electron Project

    International Nuclear Information System (INIS)

    LeClaire, B.W.

    1987-10-01

    An experimental search for selectrons, the supersymmetric partner of the electron, has been performed at the PEP storage ring at SLAC using the Mark II detector. The experimental search done was based upon hypothetical reaction in e + e - interactions at PEP center of mass energies of 29 GeV. In this reaction the selectrons, e, are assumed produced by the interaction of one of initial state electrons with a photon radiated from the other initial state electron. This latter electron is assumed to continue down the beam pipe undetected. The photon and electron then produce a selectron and a photino, γ, in the supersymmetric analog of Compton scattering. The photino is assumed to be the lightest supersymmetric particle, and as such, does not interact in the detector, thereby escaping detection very much like a neutrino. The selectron is assumed to immediately decay into an electron and photino. This electron is produced with large p perpendicular with respect to the beam pipe, since it must balance the transverse momentum carried off by the photinos. Thus, the experimental signature of the process is a single electron in the detector with a large unbalanced tranverse momentum. No events of this type were observed in the original search of 123 pb -1 of data, resulting in a cross section limit of less than 2.4 x 10 -2 pb (at the 95% CL) within the detector acceptance. This cross section upper limit applies to any process which produces anomalous single electron events with missing transverse momentum. When interpreted as a supersymmetry search it results in a lower selectron mass limit of 22.2 GeV/c 2 for the case of massless photinos. Limits for non-zero mass photinos have been calculated. 87 refs., 67 figs., 17 tabs

  7. A search for supersymmetric electrons with the Mark II detector at PEP (Positron Electron Project)

    Energy Technology Data Exchange (ETDEWEB)

    LeClaire, B.W.

    1987-10-01

    An experimental search for selectrons, the supersymmetric partner of the electron, has been performed at the PEP storage ring at SLAC using the Mark II detector. The experimental search done was based upon hypothetical reaction in e/sup +/e/sup -/ interactions at PEP center of mass energies of 29 GeV. In this reaction the selectrons, e-tilde, are assumed produced by the interaction of one of initial state electrons with a photon radiated from the other initial state electron. This latter electron is assumed to continue down the beam pipe undetected. The photon and electron then produce a selectron and a photino, ..gamma..-tilde, in the supersymmetric analog of Compton scattering. The photino is assumed to be the lightest supersymmetric particle, and as such, does not interact in the detector, thereby escaping detection very much like a neutrino. The selectron is assumed to immediately decay into an electron and photino. This electron is produced with large p perpendicular with respect to the beam pipe, since it must balance the transverse momentum carried off by the photinos. Thus, the experimental signature of the process is a single electron in the detector with a large unbalanced tranverse momentum. No events of this type were observed in the original search of 123 pb/sup -1/ of data, resulting in a cross section limit of less than 2.4 x 10/sup -2/ pb (at the 95% CL) within the detector acceptance. This cross section upper limit applies to any process which produces anomalous single electron events with missing transverse momentum. When interpreted as a supersymmetry search it results in a lower selectron mass limit of 22.2 GeV/c/sup 2/ for the case of massless photinos. Limits for non-zero mass photinos have been calculated. 87 refs., 67 figs., 17 tabs.

  8. BOOK REVIEW: Electron acceleration in the aurora and beyond

    Science.gov (United States)

    McClements, K. G.

    1999-08-01

    Duncan Bryant is a retired space plasma physicist who spent most of his career at the Rutherford-Appleton Laboratory in Oxfordshire, England. For many years he has been challenging a widely accepted theory, that auroral electrons are accelerated by double layers, on the grounds that it contains a fundamental error (allegedly, an implicit assumption that charged particles can gain energy from conservative fields). It is, of course, right that models of particle acceleration in natural plasmas should be scrutinized carefully in terms of their consistency with basic physical principles, and I believe that Dr Bryant has performed a valuable service by highlighting this issue. He maintains that auroral electron acceleration by double layers is fundamentally untenable, and that acceleration takes place instead via resonant interactions with lower hybrid waves. In successive chapters, he asserts that essentially the same process can account for electron acceleration observed at the Earth's bow shock, in the neighbourhood of an `artificial comet' produced as part of the Active Magnetospheric Particle Explorers (AMPTE) space mission in 1984/85, in the solar wind, at the Earth's magnetopause, and in the Earth's magneto- sphere. The evidence for this is not always convincing: waves with frequencies of the order of the lower hybrid resonance are often observed in these plasma environments, but in general it is difficult to identify clearly which wave mode is being observed (whistlers, for example, have frequencies in approximately the same range as lower hybrid waves). Moreover, it is not at all clear that the waves which are observed, even if they were of the appropriate type, would have sufficient intensity to accelerate electrons to the extent observed. The author makes a persuasive case, however, that acceleration in the aurora, and in other plasma environments accessible to in situ measurements, involves some form of wave turbulence. In Chapter 2 it is pointed out that

  9. Aurora kinase A as a possible marker for endocrine resistance in early estrogen receptor positive breast cancer

    DEFF Research Database (Denmark)

    Lykkesfeldt, Anne E; Iversen, Benedikte R; Jensen, Maj-Britt

    2018-01-01

    in 980 tumors and semi quantitively scored into three groups; negative/weak, moderate and high. The Aurora A expression levels were compared to other clinico-pathological parameters and outcome, defined as disease-free survival (DFS) and overall survival (OS). RESULTS: High expression of Aurora......BACKGROUND: Cell culture studies have disclosed that the mitotic Aurora kinase A is causally involved in both tamoxifen and aromatase inhibitor resistant cell growth and thus may be a potential new marker for endocrine resistance in the clinical setting. MATERIAL AND METHODS: Archival tumor tissue...... A was found in 26.9% of patients and moderate in 57.0%. High expression was significantly associated with high malignancy grade and HER2 amplification. High Aurora A expression was significantly more frequent in ductal compared to lobular carcinomas. We found no significant association between Aurora...

  10. Level II Cultural Resource investigation for the Texoma Distribution Enhancements project, Cameron and Calcasieu Parishes, Louisiana: Final report

    Energy Technology Data Exchange (ETDEWEB)

    LeeDecker, C. H.; Holland, C. C.

    1987-10-01

    A Level II Cultural Resource Survey was completed for the Texoma Distribution Enhancements project, located in Cameron and Calcasieu Parishes, Louisiana. The 13-mile pipeline extends from Strategic Petroleum Reserve No. 3 to a terminus near Vincent Landing. Located in Louisiana's southwest coastal zone, the pipeline will traverse extensive marsh lands as well as upland prairie terrace areas. Present land use within the project area consists primarily of undeveloped marsh land and cattle range. The study methods included background research, intensive pedestrian survey with systematic shovel testing, a boat survey, and laboratory analysis of recovered artifact collections. One historic site, 16CU205, was identified during the field survey, and it was tested for National Register eligibility. The site is assignable to the Industrialization and Modernization (1890-1940) Cultural Unit. Archaeological testing indicates that it is a rural residence or farmstead, with a house and one outbuilding within the proposed right-of-way. The site lacks significant historical association and sufficient archaeological integrity to merit inclusion on the National Register of Historic Places. Four standing structures were also identified during the field survey. The structures are agricultural outbuildings, less than 40 years in age, that possess no architectural distinction or historical association. They have been documented photographically and by scaled plan drawings, but do not merit additional study prior to their destruction. 24 refs., 15 figs., 3 tabs.

  11. CINCH-II project. Next step in the coordination of education in nuclear- and radiochemistry in Europe

    International Nuclear Information System (INIS)

    John, Jan; Cuba, Vaclav; Nemec, Mojmir

    2013-01-01

    Any of the potential options for the nuclear power – both the renaissance, if any, or the phase out – will require significant numbers of the respective specialists, amongst others the nuclear and/or radiochemists. In parallel, a significant demand exists for these specialists in non-energy fields, such as environmental protection, radiopharmacy, nuclear medicine, biology, authorities, etc. Since the numbers of staff in teaching and the number of univerzities with facilities licensed for the work with open sources of ionizing radiation has decreased on or sometimes even below the critical level, coordination and collaboration are required to maintain the necessary teaching and training capabilities. The CINCH-II project, aiming at the Coordination of education and training In Nuclear CHemistry in Europe, will be a direct continuation of the CINCH-I project which, among others, identified the EuroMaster in Nuclear Chemistry quality label recognized and guaranteed by the European Chemistry Thematic Network Association as an optimum common mutual recognition system in the field of education in Nuclear Chemistry in Europe, surveyed the status of Nuclear Chemistry in industry / the needs of the end-users, developed an efficient system of education/training compact modular courses, or developed and tested two electronic tools as a basis of a future efficient distance learning system. In the first part of this paper, the achievements of the CINCH-I project will be described. This description will cover both the status review and the development activities of this Collaboration. In the status review field, the results of a detailed survey of the universities and curricula in nuclear- and radiochemistry in Europe and Russia will be presented. Another survey mapped the nuclear- and radiochemistry in industry – specifically the training and education needs of the end users. In the development activities field, the main achievements of the CINCH-project will be presented

  12. Energies of precipitating electrons during pulsating aurora events derived from ionosonde observations

    International Nuclear Information System (INIS)

    MacDougall, J.W.; Hofstee, J.; Koehler, J.A.

    1981-01-01

    The time-history of particle energies and fluxes associated with pulsating auroras in the morning sector is derived from ionosonde measurements. All the pulsating auroras studied showed a similar history with the pulsations occurring during a time interval of the order of an hour during which the average auroral Maxwellian characteristic energy stays relatively constant but the energy flux decreases progressively during the event. A possible explanation for this behaviour in terms of an injection of particles into a magnetospheric 'bottle' near the midnight meridian and the progressive precipitation out of the bottle during the pulsating event is suggested. (auth)

  13. The Lazarus project. II. Spacelike extraction with the quasi-Kinnersley tetrad

    International Nuclear Information System (INIS)

    Campanelli, Manuela; Kelly, Bernard; Lousto, Carlos O.

    2006-01-01

    The Lazarus project was designed to make the most of limited 3D binary black-hole simulations, through the identification of perturbations at late times, and subsequent evolution of the Weyl scalar Ψ 4 via the Teukolsky formulation. Here we report on new developments, employing the concept of the 'quasi-Kinnersley' (transverse) frame, valid in the full nonlinear regime, to analyze late-time numerical space-times that should differ only slightly from Kerr. This allows us to extract the essential information about the background Kerr solution, and through this, to identify the radiation present. We explicitly test this procedure with full-numerical evolutions of Bowen-York data for single spinning black holes, head-on and orbiting black holes near the ISCO regime. These techniques can be compared with previous Lazarus results, providing a measure of the numerical-tetrad errors intrinsic to the method, and giving as a by-product a more robust wave extraction method for numerical elativity

  14. Canned motor pumps at Heavy Water Project, Baroda [Paper No.: II-2

    International Nuclear Information System (INIS)

    Batra, R.K.; Waishampayan, S.G.

    1981-01-01

    Heavy Water Project, Baroda is having special canned motor pumps for pumping ammonia and potassium amide. These pumps work under a pressure of 640 kg/cm 2 and are lubricated and cooled by the same fluid. These pumps are having special bearings consisting of mating surfaces of tungsten carbine Vs ceramic or stellite Vs carbon depending upon application. The total number of such pumps installed in the plant is around 52. These pumps being installed in high pressure vessels working at a pressure of 640 kg/cm 2 have special maintenance problems and need special care during maintenance. Pumps once boxed up are completely out of reach for immediate maintenance if needed. The failure of these pumps may mean a down time of one to two months for the plant. Besides above, there are multistage barrel type ammonia pumps with 24 stages developing a pressure of 140 kg/cm 2 . All these equipments need special maintenance methods as the problems faced are varied and difficult to solve. This paper deals with general and unique type of problems faced on these pumps. (author)

  15. Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway

    International Nuclear Information System (INIS)

    Tseng, Ya-Shih; Lee, Jenq-Chang; Huang, Chi-Ying F; Liu, Hsiao-Sheng

    2009-01-01

    Overexpression of Aurora-A and mutant Ras (Ras V12 ) together has been detected in human bladder cancer tissue. However, it is not clear whether this phenomenon is a general event or not. Although crosstalk between Aurora-A and Ras signaling pathways has been reported, the role of these two genes acting together in tumorigenesis remains unclear. Real-time PCR and sequence analysis were utilized to identify Ha- and Ki-ras mutation (Gly -> Val). Immunohistochemistry staining was used to measure the level of Aurora-A expression in bladder and colon cancer specimens. To reveal the effect of overexpression of the above two genes on cellular responses, mouse NIH3T3 fibroblast derived cell lines over-expressing either Ras V12 and wild-type Aurora-A (designated WT) or Ras V12 and kinase-inactivated Aurora-A (KD) were established. MTT and focus formation assays were conducted to measure proliferation rate and focus formation capability of the cells. Small interfering RNA, pharmacological inhibitors and dominant negative genes were used to dissect the signaling pathways involved. Overexpression of wild-type Aurora-A and mutation of Ras V12 were detected in human bladder and colon cancer tissues. Wild-type Aurora-A induces focus formation and aggregation of the Ras V12 transformants. Aurora-A activates Ral A and the phosphorylation of AKT as well as enhances the phosphorylation of MEK, ERK of WT cells. Finally, the Ras/MEK/ERK signaling pathway is responsible for Aurora-A induced aggregation of the Ras V12 transformants. Wild-type-Aurora-A enhances focus formation and aggregation of the Ras V12 transformants and the latter occurs through modulating the Ras/MEK/ERK signaling pathway

  16. Proposed Tenaska Washington II Generation Project : Final Environmental Impact Statement. Volume 1: Environmental Analysis and Technical Appendices.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1994-01-01

    BPA is considering whether to purchase electrical power from a proposed privately-owned combustion-turbine electrical generation plant in Washington. The plant would be fired by natural gas and would use combined-cycle technology to generate 240 average megawatts (aMW) of energy. The plant would be developed, owned, and operated by Tenaska Washington Partners II, L.P. The project would be located about 19 kilometers (12 miles) southeast of downtown Tacoma in the Frederickson Industrial Area, Pierce County. The proposed plant would occupy about half of a 6.4-hectare (16-acre) parcel and would be consistent with the industrial character of its surroundings. The proposed site is currently undeveloped and zoned for industrial use by the county. Main environmental concerns identified in the scoping process and in comments on the Draft Environmental Impact Statement (EIS) include: (1) potential air quality impacts, such as emissions and their contribution to the {open_quotes}greenhouse{close_quotes} effect; (2) potential health and safety impacts, such as nuisance odors, plant safety, visibility and heat-emission systems which may affect low-flying planes and potential health effects of electric and magnetic fields; and (3) potential water quality and quantity impacts, such as the amount of wastewater to be discharged, the source and amount of water required for plant operation. These and other issues are discussed in detail in the EIS. The proposed project already includes many features designed to reduce environmental impacts. Based on investigations performed for the EIS, no significant unavoidable adverse environmental impacts associated with the proposed project were identified, and no evidence emerged to suggest that the proposed action is controversial. The EIS is being mailed to numerous agencies, groups, and individuals (see Section 8.0). There will be a 30-day no-action period before any decisions are made and the Record of Decision is signed.

  17. THE AGORA HIGH-RESOLUTION GALAXY SIMULATIONS COMPARISON PROJECT. II. ISOLATED DISK TEST

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ji-hoon [Kavli Institute for Particle Astrophysics and Cosmology, SLAC National Accelerator Laboratory, Menlo Park, CA 94025 (United States); Agertz, Oscar [Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH (United Kingdom); Teyssier, Romain; Feldmann, Robert [Centre for Theoretical Astrophysics and Cosmology, Institute for Computational Science, University of Zurich, Zurich, 8057 (Switzerland); Butler, Michael J. [Max-Planck-Institut für Astronomie, D-69117 Heidelberg (Germany); Ceverino, Daniel [Zentrum für Astronomie der Universität Heidelberg, Institut für Theoretische Astrophysik, D-69120 Heidelberg (Germany); Choi, Jun-Hwan [Department of Astronomy, University of Texas, Austin, TX 78712 (United States); Keller, Ben W. [Department of Physics and Astronomy, McMaster University, Hamilton, ON L8S 4M1 (Canada); Lupi, Alessandro [Institut d’Astrophysique de Paris, Sorbonne Universites, UPMC Univ Paris 6 et CNRS, F-75014 Paris (France); Quinn, Thomas; Wallace, Spencer [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); Revaz, Yves [Institute of Physics, Laboratoire d’Astrophysique, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne (Switzerland); Gnedin, Nickolay Y. [Particle Astrophysics Center, Fermi National Accelerator Laboratory, Batavia, IL 60510 (United States); Leitner, Samuel N. [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Shen, Sijing [Kavli Institute for Cosmology, University of Cambridge, Cambridge, CB3 0HA (United Kingdom); Smith, Britton D., E-mail: me@jihoonkim.org [Institute for Astronomy, University of Edinburgh, Royal Observatory, Edinburgh EH9 3HJ (United Kingdom); Collaboration: AGORA Collaboration; and others

    2016-12-20

    Using an isolated Milky Way-mass galaxy simulation, we compare results from nine state-of-the-art gravito-hydrodynamics codes widely used in the numerical community. We utilize the infrastructure we have built for the AGORA High-resolution Galaxy Simulations Comparison Project. This includes the common disk initial conditions, common physics models (e.g., radiative cooling and UV background by the standardized package Grackle) and common analysis toolkit yt, all of which are publicly available. Subgrid physics models such as Jeans pressure floor, star formation, supernova feedback energy, and metal production are carefully constrained across code platforms. With numerical accuracy that resolves the disk scale height, we find that the codes overall agree well with one another in many dimensions including: gas and stellar surface densities, rotation curves, velocity dispersions, density and temperature distribution functions, disk vertical heights, stellar clumps, star formation rates, and Kennicutt–Schmidt relations. Quantities such as velocity dispersions are very robust (agreement within a few tens of percent at all radii) while measures like newly formed stellar clump mass functions show more significant variation (difference by up to a factor of ∼3). Systematic differences exist, for example, between mesh-based and particle-based codes in the low-density region, and between more diffusive and less diffusive schemes in the high-density tail of the density distribution. Yet intrinsic code differences are generally small compared to the variations in numerical implementations of the common subgrid physics such as supernova feedback. Our experiment reassures that, if adequately designed in accordance with our proposed common parameters, results of a modern high-resolution galaxy formation simulation are more sensitive to input physics than to intrinsic differences in numerical schemes.

  18. Stripa Project. Part II: Measurement of triaxial rock stresses in borehole V1

    International Nuclear Information System (INIS)

    Strindell, L.; Andersson, M.

    1981-07-01

    The investigation was performed December 16-18, 1980 and February 2-5, 1981 by Lars Strindell and Mats Andersson, Swedish State Power Board. The drilling was carried out by Hagby Bruk, Nora. One of the tasks within the project is to drill a vertical hole with a diameter of 76 mm to 1050 meters depth. The drilling is performed from a place in the mine at about 360 m below ground level. Hydrologic investigations will be performed in the borehole and knowledge about the existing rock pressure will aid the interpretation of the hydrology data. The intention was to perform 4 measurements at depth of 150, 300 and 450 m respectively. At present, measurements have been carried out at 150 and 300 m depth. At 450 m the quality of the rock was too poor to allow any measurements. The drilling has been interrupted at 506 m depth but the plan is to continue when the borehole has been stabilized along the highly fractured zone. At 150 m the average stresses in the horizontal plane is about 25 MPa in E-W direction and about 20 MPa in the N-S direction. In the region just below 300 m the average stresses is about 20 MPa in the NE-SW direction and about 12 MPa in NW-SE direction. The average vertical stress at 150 m depth is 13.5 MPa and this is in good agreement with the theoretical value. At 300 m the vertical stress is about 13.8 MPa which is somewhat lower than the theoretical value. (author)

  19. WISDOM Project - II. Molecular gas measurement of the supermassive black hole mass in NGC 4697

    Science.gov (United States)

    Davis, Timothy A.; Bureau, Martin; Onishi, Kyoko; Cappellari, Michele; Iguchi, Satoru; Sarzi, Marc

    2017-07-01

    As part of the mm-Wave Interferometric Survey of Dark Object Masses (WISDOM) project, we present an estimate of the mass of the supermassive black hole (SMBH) in the nearby fast-rotating early-type galaxy NGC 4697. This estimate is based on Atacama Large Millimeter/submillimeter Array (ALMA) cycle-3 observations of the 12CO(2-1) emission line with a linear resolution of 29 pc (0.53 arcsec). We find that NGC 4697 hosts a small relaxed central molecular gas disc with a mass of 1.6 × 107 M⊙, co-spatial with the obscuring dust disc visible in optical Hubble Space Telescope imaging. We also resolve thermal 1 mm continuum emission from the dust in this disc. NGC 4697 is found to have a very low molecular gas velocity dispersion, σgas = 1.65^{+0.68}_{-0.65} km s-1. This seems to be partially because the giant molecular cloud mass function is not fully sampled, but other mechanisms such as chemical differentiation in a hard radiation field or morphological quenching also seem to be required. We detect a Keplerian increase of the rotation of the molecular gas in the very centre of NGC 4697, and use forward modelling of the ALMA data cube in a Bayesian framework with the KINematic Molecular Simulation (kinms) code to estimate an SMBH mass of (1.3_{-0.17}^{+0.18}) × 108 M⊙ and an I-band mass-to-light ratio of 2.14_{-0.05}^{+0.04} M⊙/L⊙ (at the 99 per cent confidence level). Our estimate of the SMBH mass is entirely consistent with previous measurements from stellar kinematics. This increases confidence in the growing number of SMBH mass estimates being obtained in the ALMA era.

  20. The Carolina Bay Restoration Project - Status Report II 2000-2004.

    Energy Technology Data Exchange (ETDEWEB)

    Barton, Christopher

    2006-07-13

    A Wetlands Mitigation Bank was established at SRS in 1997 as a compensatory alternative for unavoidable wetland losses. Prior to restoration activities, 16 sites included in the project were surveyed for the SRS Site Use system to serve as a protective covenant. Pre-restoration monitoring ended in Fall 2000, and post restoration monitoring began in the Winter/Spring of 2001. The total interior harvest in the 16 bays after harvesting the trees was 19.6 ha. The margins in the opencanopy, pine savanna margin treatments were thinned. Margins containing areas with immature forested stands (bay 5184 and portions of bay 5011) were thinned using a mechanical shredder in November 2001. Over 126 hectares were included in the study areas (interior + margin). Planting of two tree species and the transplanting of wetland grass species was successful. From field surveys, it was estimated that approximately 2700 Nyssa sylvatica and 1900 Taxodium distichum seedlings were planted in the eight forested bays resulting in an average planting density of ≈ 490 stems ha-1. One hundred seedlings of each species per bay (where available) were marked to evaluate survivability and growth. Wetland grass species were transplanted from donor sites on SRS to plots that ranged in size from 100 – 300 m2, depending on wetland size. On 0.75 and 0.6 meter centers, respectively, 2198 plugs of Panicum hemitomon and 3021 plugs Leersia hexandra were transplanted. New shoots originating from the stumps were treated with a foliar herbicide (Garlon® 4) during the summer of 2001 using backpack sprayers. Preliminary information from 2000-2004 regarding the hydrologic, vegetation and faunal response to restoration is presented in this status report. Post restoration monitoring will continue through 2005. A final report to the Mitigation Bank Review Team will be submitted in mid-2006.

  1. FEBEX II Project Final report on thermo-hydro-mechanical laboratory tests

    Energy Technology Data Exchange (ETDEWEB)

    Lloret, A.; Romero, E.; Villar, M. V.

    2004-07-01

    The results of the thermo-hydro-mechanical (THM) study of the FEBEX bentonite performed during FEBEX II are presented. The laboratory test program continued in part with the works carried out during FEBEX I, particularly in activities related to tests aimed to the calibration of the models, the acquisition of parameters by back-analysis and the improvement of the knowledge on the behaviour of expansive clays. But the program has also included tests on new areas: investigations about the influence of the microstructure changes in bentonite, of temperature and of the solute concentration on the behaviour of clay. Besides, several tests were proposed in order to understand the unexpected behaviour observed in the mock-up test, towards the end of year 2. Temperature effects on water retention curves in confined and unconfined conditions were determined, and swelling pressure, hydraulic conductivity and swelling and consolidation strains as a function of temperature were successfully measured. Different experimental techniques and equipments were developed to study thermal induced changes under partially saturated states, covering a wide range of suctions. FEBEX bentonite remains suitable as a sealing material in HLW repositories (from the hydro- mechanical point of view) for temperatures of up to 80 C, as it keeps its high water retention capacity, low permeability and self-healing ability. The extrapolation of results points out to the preservation of properties for at least up to 100 C. Mercury intrusion porosimetry and environmental scanning electron microscopy provided promising results in order to characterise the bentonite microstructure and to give information about the mechanisms influencing pore size distribution changes on high active clays. The use of digital imaging techniques allowed verifying that at micro-scale level, where chemical phenomena prevail, strains are almost reversible as it is considered in the two-level elasto-plastic models. The swelling

  2. FEBEX II Project Final report on thermo-hydro-mechanical laboratory tests

    International Nuclear Information System (INIS)

    Lloret, A.; Romero, E.; Villar, M. V.

    2004-01-01

    The results of the thermo-hydro-mechanical (THM) study of the FEBEX bentonite performed during FEBEX II are presented. The laboratory test program continued in part with the works carried out during FEBEX I, particularly in activities related to tests aimed to the calibration of the models, the acquisition of parameters by back-analysis and the improvement of the knowledge on the behaviour of expansive clays. But the program has also included tests on new areas: investigations about the influence of the microstructure changes in bentonite, of temperature and of the solute concentration on the behaviour of clay. Besides, several tests were proposed in order to understand the unexpected behaviour observed in the mock-up test, towards the end of year 2. Temperature effects on water retention curves in confined and unconfined conditions were determined, and swelling pressure, hydraulic conductivity and swelling and consolidation strains as a function of temperature were successfully measured. Different experimental techniques and equipments were developed to study thermal induced changes under partially saturated states, covering a wide range of suctions. FEBEX bentonite remains suitable as a sealing material in HLW repositories (from the hydro- mechanical point of view) for temperatures of up to 80 C, as it keeps its high water retention capacity, low permeability and self-healing ability. The extrapolation of results points out to the preservation of properties for at least up to 100 C. Mercury intrusion porosimetry and environmental scanning electron microscopy provided promising results in order to characterise the bentonite microstructure and to give information about the mechanisms influencing pore size distribution changes on high active clays. The use of digital imaging techniques allowed verifying that at micro-scale level, where chemical phenomena prevail, strains are almost reversible as it is considered in the two-level elasto-plastic models. The swelling

  3. GEOSAF Part II. Demonstration of the operational and long-term safety of geological disposal facilities for radioactive waste. IAEA international intercomparison and harmonization project

    Energy Technology Data Exchange (ETDEWEB)

    Kumano, Yumiko; Bruno, Gerard [International Atomic Energy Agency, Vienna (Austria). Vienna International Centre; Tichauer, Michael [IRSN, Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France); Hedberg, Bengt [Swedish Radiation Safety Authority, Stockholm (Sweden)

    2015-07-01

    International intercomparison and harmonization projects are one of the mechanisms developed by the IAEA for examining the application and use of safety standards, with a view to ensuring their effectiveness and working towards harmonization of approaches to the safety of radioactive waste management. The IAEA has organized a number of international projects on the safety of radioactive waste management; in particular on the issues related to safety demonstration for radioactive waste management facilities. In 2008, GEOSAF, Demonstration of The Operational and Long-Term Safety of Geological Disposal Facilities for Radioactive Waste, project was initiated. This project was completed in 2011 by delivering a project report focusing on the safety case for geological disposal facilities, a concept that has gained in recent years considerable prominence in the waste management area and is addressed in several international safety standards. During the course of the project, it was recognized that little work was undertaken internationally to develop a common view on the safety approach related to the operational phase of a geological disposal although long-term safety of disposal facility has been discussed for several decades. Upon completion of the first part of the GEOSAF project, it was decided to commence a follow-up project aiming at harmonizing approaches on the safety of geological disposal facilities for radioactive waste through the development of an integrated safety case covering both operational and long-term safety. The new project was named as GEOSAF Part II, which was initiated in 2012 initially as 2-year project, involving regulators and operators. GEOSAF Part II provides a forum to exchange ideas and experience on the development and review of an integrated operational and post-closure safety case for geological disposal facilities. It also aims at providing a platform for knowledge transfer. The project is of particular interest to regulatory

  4. Public Values and Stakeholder Involvement - A new framework for Performance Assessment? The European Project RISCOM-II. Work Package 1

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Kjell [Karinta-Konsult, Taeby (Sweden); Chataignier, Stephane [Electricite de France (France); Drottz-Sjoeberg, Britt-Marie [BMD Research (Sweden)] [and others

    2002-11-01

    RISCOM-II is a project within the fifth framework programme of the European Commission. It is based on a widely recognised need for more transparent decision processes in nuclear waste management. The objective of the RISCOM-II project is to share the knowledge of the context of radioactive waste management in various European countries and to see to what extent it is possible to apply more widely the RISCOM Model in order to improve the acceptability of radioactive waste management. Thus, the project aims to promote the development of processes involving transparency, as well as means involving greater participation of the public. Key topics studied in the RISCOM-II Project are issues in risk assessment to better understand how factual elements relate to value-laden issues and how stakeholder concerns can be addressed, as well as organizational issues affecting transparency in Europe. A range of public participation processes are analysed, some will be selected for testing and hearings are evaluated with respect to transparency. There are five participating countries: Sweden, the United Kingdom, Finland, the Czech Republic, and France, which are represented by various organizations: safety or radiation protection authorities, operators involved in nuclear wastes and the production of nuclear power, research institutes or organizations, and consultants. Work Package No 1(WP-1), Public values and performance assessment, emphasises the importance of value-laden issues involved in nuclear waste management. The expert dominance in the field has so far tended to avoid values or deal with them in seemingly factual frameworks. The objectives of (WP-1) are thus: 1. to identify value-laden issues raised by performance assessment, trying to understand how factual and technical elements relate to value-laden issues 2. to find value judgements of stakeholders, and explore if and how they could be addressed in performance assessment 3. to initiate open debate about risk and

  5. Public Values and Stakeholder Involvement - A new framework for Performance Assessment? The European Project RISCOM-II. Work Package 1

    International Nuclear Information System (INIS)

    Andersson, Kjell; Chataignier, Stephane; Drottz-Sjoeberg, Britt-Marie

    2002-11-01

    RISCOM-II is a project within the fifth framework programme of the European Commission. It is based on a widely recognised need for more transparent decision processes in nuclear waste management. The objective of the RISCOM-II project is to share the knowledge of the context of radioactive waste management in various European countries and to see to what extent it is possible to apply more widely the RISCOM Model in order to improve the acceptability of radioactive waste management. Thus, the project aims to promote the development of processes involving transparency, as well as means involving greater participation of the public. Key topics studied in the RISCOM-II Project are issues in risk assessment to better understand how factual elements relate to value-laden issues and how stakeholder concerns can be addressed, as well as organizational issues affecting transparency in Europe. A range of public participation processes are analysed, some will be selected for testing and hearings are evaluated with respect to transparency. There are five participating countries: Sweden, the United Kingdom, Finland, the Czech Republic, and France, which are represented by various organizations: safety or radiation protection authorities, operators involved in nuclear wastes and the production of nuclear power, research institutes or organizations, and consultants. Work Package No 1(WP-1), Public values and performance assessment, emphasises the importance of value-laden issues involved in nuclear waste management. The expert dominance in the field has so far tended to avoid values or deal with them in seemingly factual frameworks. The objectives of (WP-1) are thus: 1. to identify value-laden issues raised by performance assessment, trying to understand how factual and technical elements relate to value-laden issues 2. to find value judgements of stakeholders, and explore if and how they could be addressed in performance assessment 3. to initiate open debate about risk and

  6. Recent laser experiments on the Aurora KrF/ICF laser system

    International Nuclear Information System (INIS)

    Turner, T.P.; Jones, J.E.; Czuchlewski, S.J.; Watt, R.G.; Thomas, S.J.; Kang, M.; Tallman, C.R.; Mack, J.M.; Figueira, J.F.

    1990-01-01

    The Aurora KrF/ICF Laser Facility at Los Alamos is operational at the kilojoule-level for both laser and target experiments. We report on recent laser experiments on the system and resulting system improvements. 3 refs., 4 figs

  7. 76 FR 65216 - Beacon Medical Services, LLC, Aurora, CO; Notice of Negative Determination Regarding Application...

    Science.gov (United States)

    2011-10-20

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-80,219] Beacon Medical Services... workers and former workers of Beacon Medical Services, LLC, Aurora, Colorado (Beacon Medical Services... published in the Federal Register on July 8, 2011 (76 FR 40401). The workers of Beacon Medical Services are...

  8. Discovery of Salamandra atra aurorae (Trevisan, 1982 on the Altopiano di Vezzena, Trentino (Northeastern Italy

    Directory of Open Access Journals (Sweden)

    Wouter Beukema

    2008-05-01

    Full Text Available Aurora’s Alpine Salamander is a limited distributed subspecies endemic to the Altopiano di Asiago, Veneto. In the current paper the occurrence of Salamandra atra aurorae is described for the Altopiano di Vezzena, Trentino. The aim of this paper is to review the distribution as well as to comment on the conservational status of the subspecies in Trentino.

  9. Aurora T: a Monte Carlo code for transportation of neutral atoms in a toroidal plasma

    International Nuclear Information System (INIS)

    Bignami, A.; Chiorrini, R.

    1982-01-01

    This paper contains a short description of Aurora code. This code have been developed at Princeton with Monte Carlo method for calculating neutral gas in cylindrical plasma. In this work subroutines such one can take in account toroidal geometry are developed

  10. Radar and photometric measurements of an intense type A red aurora

    Science.gov (United States)

    Robinson, R. M.; Mende, S. B.; Vondrak, R. R.; Kozyra, J. U.; Nagy, A. F.

    1985-01-01

    On the evening of March 5, 1981, an intense, type A red aurora appeared over southern Alaska. Radar and photometric measurements were made of the aurora from the Chatanika radar site. The line of sight intensity of the 630.0-nm emissions exceeded 150 kR and was accompanied by enhanced emissions at 486.1 and 427.8 nm. The Chatanika radar measured electron densities of 10 to the 6th per cu cm and electron temperatures of 6000 K at an altitude of 400 km and an invariant latitude of 59 deg in association with the aurora. Comparison of optical and radar measurements indicated that the 630.0-nm emissions were produced to a large degree by thermal excitation of O(1D) in the region of high electron temperatures and densities. Model calculations indicate that the observed density and temperature enhancements and the related optical emissions were the results of a relatively short duration (5-10 min) pulse of precipitating, low-energy (about 30 eV) electrons. Whereas conventional stable auroral red arcs are associated with a gradual decrease in ring current energy density during the recovery phase of a magnetic storm, the type A red aurora may be produced by impulsive ring current energy loss during the main phase.

  11. Lessons learnt from Volcanoes' Night I-II-III - a Marie Curie Researchers' Night project series dedicated to geosciences

    Science.gov (United States)

    Cseko, Adrienn; Bodo, Balazs; Ortega Rodriguez, Ariadna

    2017-04-01

    European Researchers' Nights (ERNs) are a pan-European series of events funded by the European Commission, organised on the last Friday of every September since 2005. ERNs mobilise scientific, academic and research organisations with the aim of giving the public the opportunity to meet researchers in an informal setting. The overall objective of ERNs is to achieve better awareness among the general public concerning the importance of science in everyday life and to combat stereotypes about researchers. The longer-term strategic objective of ERNs is to encourage young people to embark on a scientific career. Volcanoes' Night I-II-III has been an ERN project series funded by the EC FP7 and H2020 programmes between 2012-2015 (EC contract No. 316558, 610050, 633310, www.nochedevolcanes.es). The concept of Volcanoes' Night was created by researchers from the Canary Islands, Spain, where both the researchers and the public live in the close vicinity of volcanoes. The objective of the project was to use volcanoes as a background against which the role of geoscientists could be explained to the public. The scope of Volcanoes' Night was exclusively dedicated to geoscience, and in this respect it stands out among all other ERN projects, which are always more general in scope. During its four years of EC funding, the geographical coverage of Volcanoes' Night expanded substantially from a single location in 2012 (Fuencaliente de La Palma, Spain) to a dozen locations in 2015, mobilising multiple scientific organisations, researchers, and public authorities for engagement with the public. The last EC-funded project, Volcanoes' Night III, which was organised in 2014 and 2015, engaged approximately 21,000 visitors through its outreach activities, which included experiments, science cafés, volcano movies, My Day presentations, excursions, science workshops and more. The impact of the project was carefully assessed via surveys and social studies during its lifetime, and an Impact

  12. GENII (Generation II): The Hanford Environmental Radiation Dosimetry Software System: Volume 3, Code maintenance manual: Hanford Environmental Dosimetry Upgrade Project

    Energy Technology Data Exchange (ETDEWEB)

    Napier, B.A.; Peloquin, R.A.; Strenge, D.L.; Ramsdell, J.V.

    1988-09-01

    The Hanford Environmental Dosimetry Upgrade Project was undertaken to incorporate the internal dosimetry models recommended by the International Commission on Radiological Protection (ICRP) in updated versions of the environmental pathway analysis models used at Hanford. The resulting second generation of Hanford environmental dosimetry computer codes is compiled in the Hanford Environmental Dosimetry System (Generation II, or GENII). This coupled system of computer codes is intended for analysis of environmental contamination resulting from acute or chronic releases to, or initial contamination of, air, water, or soil, on through the calculation of radiation doses to individuals or populations. GENII is described in three volumes of documentation. This volume is a Code Maintenance Manual for the serious user, including code logic diagrams, global dictionary, worksheets to assist with hand calculations, and listings of the code and its associated data libraries. The first volume describes the theoretical considerations of the system. The second volume is a Users' Manual, providing code structure, users' instructions, required system configurations, and QA-related topics. 7 figs., 5 tabs.

  13. GENII [Generation II]: The Hanford Environmental Radiation Dosimetry Software System: Volume 3, Code maintenance manual: Hanford Environmental Dosimetry Upgrade Project

    International Nuclear Information System (INIS)

    Napier, B.A.; Peloquin, R.A.; Strenge, D.L.; Ramsdell, J.V.

    1988-09-01

    The Hanford Environmental Dosimetry Upgrade Project was undertaken to incorporate the internal dosimetry models recommended by the International Commission on Radiological Protection (ICRP) in updated versions of the environmental pathway analysis models used at Hanford. The resulting second generation of Hanford environmental dosimetry computer codes is compiled in the Hanford Environmental Dosimetry System (Generation II, or GENII). This coupled system of computer codes is intended for analysis of environmental contamination resulting from acute or chronic releases to, or initial contamination of, air, water, or soil, on through the calculation of radiation doses to individuals or populations. GENII is described in three volumes of documentation. This volume is a Code Maintenance Manual for the serious user, including code logic diagrams, global dictionary, worksheets to assist with hand calculations, and listings of the code and its associated data libraries. The first volume describes the theoretical considerations of the system. The second volume is a Users' Manual, providing code structure, users' instructions, required system configurations, and QA-related topics. 7 figs., 5 tabs

  14. CALTECH CORE-COLLAPSE PROJECT (CCCP) OBSERVATIONS OF TYPE II SUPERNOVAE: EVIDENCE FOR THREE DISTINCT PHOTOMETRIC SUBTYPES

    Energy Technology Data Exchange (ETDEWEB)

    Arcavi, Iair; Gal-Yam, Avishay; Yaron, Ofer [Department of Particle Physics and Astrophysics, Weizmann Institute of Science, Rehovot 76100 (Israel); Cenko, S. Bradley; Becker, Adam B. [Department of Astronomy, University of California, Berkeley, CA 94720-3411 (United States); Fox, Derek B. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Leonard, Douglas C. [Department of Astronomy, San Diego State University, San Diego, CA 92182 (United States); Moon, Dae-Sik [Department of Astronomy and Astrophysics, University of Toronto, Toronto, ON M5S 3H4 (Canada); Sand, David J. [Las Cumbres Observatory Global Telescope Network, Santa Barbara, CA 93117 (United States); Soderberg, Alicia M. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Kiewe, Michael [Department of Physics, University of Wisconsin, Madison, WI 53706 (United States); Scheps, Raphael [King' s College, University of Cambridge, Cambridge CB2 1ST (United Kingdom); Birenbaum, Gali [12 Amos St, Ramat Chen, Ramat Gan 52233 (Israel); Chamudot, Daniel [20 Chen St, Petach Tikvah 49520 (Israel); Zhou, Jonathan, E-mail: iair.arcavi@weizmann.ac.il [101 Dunster Street, Box 398, Cambridge, MA 02138 (United States)

    2012-09-10

    We present R-band light curves of Type II supernovae (SNe) from the Caltech Core-Collapse Project (CCCP). With the exception of interacting (Type IIn) SNe and rare events with long rise times, we find that most light curve shapes belong to one of three apparently distinct classes: plateau, slowly declining, and rapidly declining events. The last class is composed solely of Type IIb SNe which present similar light curve shapes to those of SNe Ib, suggesting, perhaps, similar progenitor channels. We do not find any intermediate light curves, implying that these subclasses are unlikely to reflect variance of continuous parameters, but rather might result from physically distinct progenitor systems, strengthening the suggestion of a binary origin for at least some stripped SNe. We find a large plateau luminosity range for SNe IIP, while the plateau lengths seem rather uniform at approximately 100 days. As analysis of additional CCCP data goes on and larger samples are collected, demographic studies of core-collapse SNe will likely continue to provide new constraints on progenitor scenarios.

  15. Aurora: Los Alamos multikilojoule angular-multiplexed KrF driver prototype for ICF

    International Nuclear Information System (INIS)

    Rosocha, L.A.; Hanlon, J.A.; McLeod, J.

    1987-01-01

    The Los Alamos National Laboratory (LANL) has participated in programs to apply high-power gas lasers to inertial confinement fusion (ICF). The bulk of this effort has been in the development of CO/sub 2/ laser systems and laser-plasma interaction experiments at a 10.6-μm wavelength. The main hardware element in this program is the Aurora KrF laser system, which is a prototype for using optical angular multiplexing and serial amplification by large electron-beam-driven KrF laser amplifiers to study KrF systems as potential fusion drivers. Aurora will serve as a test-bed for specific laser, optical, and electron-beam-pumping technology aspects of larger KrF fusion systems. The Aurora system is being built in two phases. The first-phase portion of the Aurora system contains all the main optical and laser elements from the front end to the final amplifier output. In the first phase, the front end output is replicated using aperture slicers and beam splitters to produce a 480-ns long pulse train consisting of 96 separate 5-ns pulses. This pulse train is encoded in angular separation, relayed through the amplifier chain by means of the centered optical system and the computer-controlled alignment station, and delivered to a diagnostic station which follows the main power amplifier [large aperture module (LAM)]. The second phase of the system contains the first-phase portion and the additional optical and target hardware needed to stack 48 of the 96 multiplexed and amplified beams into a single multikilojoule 5-ns pulse at the fusion target. The authors give a description of the Aurora system and discuss its present status

  16. Polar cap particle precipitation and aurora: Review and commentary

    Science.gov (United States)

    Newell, Patrick T.; Liou, Kan; Wilson, Gordon R.

    2009-02-01

    presence of ions does not fit the properties of polar rain, which can in any event be nearly absent for northward interplanetary magnetic field). One theory is that such arcs are associated with merging tailward of the cusp. Both of these common types of sun-aligned arcs fade within about 30 min of a southward IMF turning. The third, and rarest, category of sun-aligned arcs are intense, well detached from the auroral oval, contain plasma sheet origin ion precipitation as well as electrons, and persist for hours after a southward turning. These intense detached sun-aligned arcs can rapidly cross the polar cap, sometimes multiple times. Most events discussed in the literature as "theta-aurora" do not fit into this category (for example, although they may appear detached in images, they abut the oval in particle data, and do not have the persistence of detached events under southward IMF turnings). It is possible that no single theory can account for all three types of sun-aligned arcs. Solar energetic particle (SEP) events are at times used to demarcate polar cap open/closed boundaries. Although this works at times, examples exist where this method fails (e.g., very quiet conditions for which SEP reaches below L=4), and the method should be used with caution. Finally, it is shown that, although it is rare, the polar cap can at times completely close.

  17. Project 1946: Phase II

    Science.gov (United States)

    2010-07-01

    we did not yet have them in the squa- drons . In the Sukhoi, the pilot flies the aircraft; in the Mirage, it is the other way around. The pilot has...correct. Bandar-e Abbas Airport in Iran was far away. The 36th Squa- dron was supposed to fly Tu-22s out of Oman, but the runway there was too short...that entered service in the late 1970s. 204 dron was based.28 The Stark was in the wrong place at the wrong time. We defined an ex- clusion zone

  18. Projectables

    DEFF Research Database (Denmark)

    Rasmussen, Troels A.; Merritt, Timothy R.

    2017-01-01

    CNC cutting machines have become essential tools for designers and architects enabling rapid prototyping, model-building and production of high quality components. Designers often cut from new materials, discarding the irregularly shaped remains. We introduce ProjecTables, a visual augmented...... reality system for interactive packing of model parts onto sheet materials. ProjecTables enables designers to (re)use scrap materials for CNC cutting that would have been previously thrown away, at the same time supporting aesthetic choices related to wood grain, avoiding surface blemishes, and other...... relevant material properties. We conducted evaluations of ProjecTables with design students from Aarhus School of Architecture, demonstrating that participants could quickly and easily place and orient model parts reducing material waste. Contextual interviews and ideation sessions led to a deeper...

  19. Inventory of Federal energy-related environment and safety research for FY 1977. Volume II. Project listings

    Energy Technology Data Exchange (ETDEWEB)

    1978-07-01

    This volume contains Biomedical and Environmental Research, Environmental Control Technology Research, and Operational and Environmental Safety Research project listings. The projects are ordered numerically by log number.

  20. TP Atlas: integration and dissemination of advances in Targeted Proteins Research Program (TPRP)-structural biology project phase II in Japan.

    Science.gov (United States)

    Iwayanagi, Takao; Miyamoto, Sei; Konno, Takeshi; Mizutani, Hisashi; Hirai, Tomohiro; Shigemoto, Yasumasa; Gojobori, Takashi; Sugawara, Hideaki

    2012-09-01

    The Targeted Proteins Research Program (TPRP) promoted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan is the phase II of structural biology project (2007-2011) following the Protein 3000 Project (2002-2006) in Japan. While the phase I Protein 3000 Project put partial emphasis on the construction and maintenance of pipelines for structural analyses, the TPRP is dedicated to revealing the structures and functions of the targeted proteins that have great importance in both basic research and industrial applications. To pursue this objective, 35 Targeted Proteins (TP) Projects selected in the three areas of fundamental biology, medicine and pharmacology, and food and environment are tightly collaborated with 10 Advanced Technology (AT) Projects in the four fields of protein production, structural analyses, chemical library and screening, and information platform. Here, the outlines and achievements of the 35 TP Projects are summarized in the system named TP Atlas. Progress in the diversified areas is described in the modules of Graphical Summary, General Summary, Tabular Summary, and Structure Gallery of the TP Atlas in the standard and unified format. Advances in TP Projects owing to novel technologies stemmed from AT Projects and collaborative research among TP Projects are illustrated as a hallmark of the Program. The TP Atlas can be accessed at http://net.genes.nig.ac.jp/tpatlas/index_e.html .

  1. A Study of Four Library Programs for Disadvantaged Persons. Part II, Appendices B: Brooklyn Public Library Community Coordinator Project, the New York Public Library North Manhattan Project.

    Science.gov (United States)

    Winsor, Charlotte B.; Burrows, Lodema

    This document contains observations of library staff and interviews with community members about the Brooklyn Public Library Community Coordinator Project and the New York Public Library North Manhattan Project. The Community Coordinator Project employs four professional librarians to take an active part in community institutions and organizations…

  2. Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity.

    Science.gov (United States)

    Fame, Ryann M; MacDonald, Jessica L; Dunwoodie, Sally L; Takahashi, Emi; Macklis, Jeffrey D

    2016-06-15

    The neocortex contains hundreds to thousands of distinct subtypes of precisely connected neurons, allowing it to perform remarkably complex tasks of high-level cognition. Callosal projection neurons (CPN) connect the cerebral hemispheres via the corpus callosum, integrating cortical information and playing key roles in associative cognition. CPN are a strikingly diverse set of neuronal subpopulations, and development of this diversity requires precise control by a complex, interactive set of molecular effectors. We have found that the transcriptional coregulator Cited2 regulates and refines two stages of CPN development. Cited2 is expressed broadly by progenitors in the embryonic day 15.5 subventricular zone, during the peak of superficial layer CPN birth, with a progressive postmitotic refinement in expression, becoming restricted to CPN of the somatosensory cortex postnatally. We generated progenitor-stage and postmitotic forebrain-specific Cited2 conditional knock-out mice, using the Emx1-Cre and NEX-Cre mouse lines, respectively. We demonstrate that Cited2 functions in progenitors, but is not necessary postmitotically, to regulate both (1) broad generation of layer II/III CPN and (2) acquisition of precise area-specific molecular identity and axonal/dendritic connectivity of somatosensory CPN. This novel CPN subtype-specific and area-specific control from progenitor action of Cited2 adds yet another layer of complexity to the multistage developmental regulation of neocortical development. This study identifies Cited2 as a novel subtype-specific and area-specific control over development of distinct subpopulations within the broad population of callosal projection neurons (CPN), whose axons connect the two cerebral hemispheres via the corpus callosum (CC). Currently, how the remarkable diversity of CPN subtypes is specified, and how they differentiate to form highly precise and specific circuits, are largely unknown. We found that Cited2 functions within

  3. Design and performance of large area monolithic electron guns for the Aurora KrF laser system

    International Nuclear Information System (INIS)

    Kang, M.; Rosocha, L.A.; Romero, V.O.; Van Haaften, F.W.; Brucker, J.P.

    1985-01-01

    Aurora is an inertial confinement fusion laser system using optical angular multiplexing and a chain of four cold cathode electron beam driven KrF laser amplifiers to produce 10 to 20 kJ of optical energy

  4. BAROMETRIC PRESSURE and Other Data from AURORA AUSTRALIS and Other Platforms from 19910106 to 19920306 (NODC Accession 9500152)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Conductivity, Temperature and Depth (CTD) and other data were collected from Ship AURORA AUSTRALIS. The data was collected over a period spanning from January 6,...

  5. Identification of critical chemical features for Aurora kinase-B inhibitors using Hip-Hop, virtual screening and molecular docking

    Science.gov (United States)

    Sakkiah, Sugunadevi; Thangapandian, Sundarapandian; John, Shalini; Lee, Keun Woo

    2011-01-01

    This study was performed to find the selective chemical features for Aurora kinase-B inhibitors using the potent methods like Hip-Hop, virtual screening, homology modeling, molecular dynamics and docking. The best hypothesis, Hypo1 was validated toward a wide range of test set containing the selective inhibitors of Aurora kinase-B. Homology modeling and molecular dynamics studies were carried out to perform the molecular docking studies. The best hypothesis Hypo1 was used as a 3D query to screen the chemical databases. The screened molecules from the databases were sorted based on ADME and drug like properties. The selective hit compounds were docked and the hydrogen bond interactions with the critical amino acids present in Aurora kinase-B were compared with the chemical features present in the Hypo1. Finally, we suggest that the chemical features present in the Hypo1 are vital for a molecule to inhibit the Aurora kinase-B activity.

  6. Spectral characteristics of aurorae connected with high-velocity flows of the solar wind from coronal holes

    International Nuclear Information System (INIS)

    Khviyuzova, T.A.; Leont'ev, S.V.

    1997-01-01

    Bright electron aurorae almost always followed by red lower edge occur when the Earth is being passed by high-velocity flows from coronal holes within the auroral range at the night meridian. In contrast to other types of the solar wind the high-velocity flows from coronal holes do not cause the occurrence of A type red polar aurorae, that is, the spectrum of electrons pouring into the Earth atmosphere in these cases is shifted towards higher energies

  7. Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

    International Nuclear Information System (INIS)

    Lentini, Laura; Amato, Angela; Schillaci, Tiziana; Di Leonardo, Aldo

    2007-01-01

    Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN). CIN is characterized by chromosomal aberrations, gains or losses of whole chromosomes (aneuploidy), and it is often associated with centrosome amplification. Centrosomes control cell division by forming a bipolar mitotic spindle and play an essential role in the maintenance of chromosomal stability. However, whether centrosome amplification could directly cause aneuploidy is not fully established. Also, alterations in genes required for mitotic progression could be involved in CIN. A major candidate is represented by Aurora-A/STK15 that associates with centrosomes and is overexpressed in several types of human tumour. Centrosome amplification were induced by hydroxyurea treatment and visualized by immunofluorescence microscopy. Aurora-A/STK15 ectopic expression was achieved by retroviral infection and puromycin selection in HCT116 tumour cells. Effects of Aurora-A/STK15 depletion on centrosome status and ploidy were determined by Aurora-A/STK15 transcriptional silencing by RNA interference. Changes in the expression levels of some mitotic genes were determined by Real time RT-PCR. We investigated whether amplification of centrosomes and overexpression of Aurora-A/STK15 induce CIN using as a model system a colon carcinoma cell line (HCT116). We found that in HCT116 cells, chromosomally stable and near diploid cells harbouring a MIN phenotype, centrosome amplification induced by hydroxyurea treatment is neither maintained nor induces aneuploidy. On the contrary, ectopic overexpression of Aurora-A/STK15 induced supernumerary centrosomes and aneuploidy. Aurora-A/STK15 transcriptional silencing by RNA interference in cells ectopically overexpressing this kinase promptly decreased cell numbers with supernumerary centrosomes and aneuploidy. Our results show that centrosome amplification alone is not sufficient

  8. Urotensin II promotes vagal-mediated bradycardia by activating cardiac-projecting parasympathetic neurons of nucleus ambiguus.

    Science.gov (United States)

    Brailoiu, Gabriela Cristina; Deliu, Elena; Rabinowitz, Joseph E; Tilley, Douglas G; Koch, Walter J; Brailoiu, Eugen

    2014-05-01

    Urotensin II (U-II) is a cyclic undecapeptide that regulates cardiovascular function at central and peripheral sites. The functional role of U-II nucleus ambiguus, a key site controlling cardiac tone, has not been established, despite the identification of U-II and its receptor at this level. We report here that U-II produces an increase in cytosolic Ca(2+) concentration in retrogradely labeled cardiac vagal neurons of nucleus ambiguus via two pathways: (i) Ca(2+) release from the endoplasmic reticulum via inositol 1,4,5-trisphosphate receptor; and (ii) Ca(2+) influx through P/Q-type Ca(2+) channels. In addition, U-II depolarizes cultured cardiac parasympathetic neurons. Microinjection of increasing concentrations of U-II into nucleus ambiguus elicits dose-dependent bradycardia in conscious rats, indicating the in vivo activation of the cholinergic pathway controlling the heart rate. Both the in vitro and in vivo effects were abolished by the urotensin receptor antagonist, urantide. Our findings suggest that, in addition, to the previously reported increase in sympathetic outflow, U-II activates cardiac vagal neurons of nucleus ambiguus, which may contribute to cardioprotection. © 2014 International Society for Neurochemistry.

  9. Overview of the 2006-2008 JOGMEC/NRCan/Aurora Mallik Gas Hydrate Production Test Program

    Science.gov (United States)

    Yamamoto, K.; Dallimore, S. R.

    2008-12-01

    During the winters of 2007 and 2008 the Japan Oil, Gas and Metals National Corporation (JOGMEC) and Natural Resources Canada (NRCan), with Aurora Research Institute as the operator, carried out an on-shore gas hydrate production test program at the Mallik site, Mackenzie Delta, Northwest Territories, Canada. The prime objective of the program was to verify the feasibility of depressurization technique by drawing down the formation pressure across a 12m perforated gas hydrate bearing section. This project was the second full scale production test at this site following the 2002 Japex/JNOC/GSC et al Mallik research program in which seven participants organizatinos from five countries undertook a thermal test using hot water circulation Field work in 2007 was devoted to establishing a production test well, installing monitoring devices outside of casing, conducting base line geophysical studies and undertaking a short test to gain practical experience prior to longer term testing planned for 2008 . Hydrate-dissociated gas was produced to surface by depressurization achieved by lowering the fluid level with a dowhole pump. However, the operation was terminated 60 hours after the start of the pumping mainly due to sand production problems. In spite of the short period (12.5 hours of ellapsed pumping time), at least 830m3 of the gas was produced and accumulated in the borehole. Sand screens were installed across the perforated interval at the bottom hole for the 2008 program to overcome operational problems encountered in 2007 and achieve sustainable gas production. Stable bottom hole flowing pressures were successfully achieved during a 6 day test with continuous pump operation. Sustained gas production was achieved with rates between 2000- 4000m3/day and cummulative gas volume in the surface of approximately 13,000m3. Temperature and pressure data measured at the bottom hole and gas and water production rates gave positive evidence for the high efficiency of gas

  10. Time sequence analysis of flickering auroras. I - Application of Fourier analysis. [in atmosphere

    Science.gov (United States)

    Berkey, F. T.; Silevitch, M. B.; Parsons, N. R.

    1980-01-01

    Using a technique that enables one to digitize the brightness of auroral displays from individual fields of a video signal, we have analyzed the frequency content of flickering aurora. Through the application of Fourier analysis to our data, we have found that flickering aurora contains a wide range of enhanced frequencies, although the dominant frequency enhancement generally occurs in the range 6-12 Hz. Each incidence of flickering that we observed was associated with increased radio wave absorption. Furthermore, we have found that flickering occurs in bright auroral surges, the occurrence of which is not limited to the 'breakup' phase of auroral substorms. Our results are interpreted in terms of a recently proposed theory of fluctuating double layers that accounts for a number of the observational features.

  11. Aurora multikilojoule KrF laser system prototype for inertial confinement fusion

    International Nuclear Information System (INIS)

    Rosocha, L.A.; Hanlon, J.A.; Mc Leod, J.; Kang, M.; Kortegaard, B.L.; Burrows, M.D.; Bowling, P.S.

    1987-01-01

    Aurora is the Los Alamos National Laboratory short-pulse, high-power, KrF laser system. It serves as an end-to-end technology demonstration for large-scale ultraviolet laser systems of interest for short wavelength, inertial confinement fusion (ICF) investigations. The systems is a prototype for using optical angular multiplexing and serial amplification by large electron-beam-driven KrF laser amplifiers to deliver stacked, 248-nm, 5-ns duration multikilojoule laser pulses to ICF targets using an --1-km-long optical beam path. The entire Aurora KrF laser system is described and the design features of the following major system components are summarized: front-end lasers, amplifier train, multiplexer, optical relay train, demultiplexer, target irradiation apparatus, and alignment and controls systems

  12. Macro-micro interlocked simulation algorithm: an exemplification for aurora arc evolution

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Tetsuya [University of Hyogo, Kobe 650-0044 (Japan); Hasegawa, Hiroki; Ohno, Nobuaki [Japan Agency for Marine-Earth Science and Technology, Yokohama 236-0001 (Japan)], E-mail: sato@hq.u-hyogo.ac.jp

    2009-01-01

    Using an innovative holistic simulation algorithm that can self-consistently treat a system that evolves as cooperation between macroscopic and microscopic processes, the evolution of a colorful aurora arc is beautifully reproduced as the result of cooperation between the global field-aligned feedback instability of the coupled magnetosphere-ionosphere system and the ensuing microscopic ion-acoustic instability that generates electric double layers and accelerates aurora electrons. These results are in agreement with rocket and satellite observations. This shows that the proposed holistic algorithm could be a reliable tool to reveal complex real dramatic events and become, in the near future, a viable scientifically secure prediction tool for natural disasters such as earthquakes, landslides and floods caused by typhoons.

  13. Computer control system of the superconducting SR-light source ''Aurora''

    International Nuclear Information System (INIS)

    Yamada, H.

    1989-01-01

    The Aurora is a compact SR-light system optimized for x-ray lithography. The system includes a superconducting electron storage ring, a 150-MeV race track microtron as an injector, and light beamlines. The SR-ring features a single magnet body, in which the 650-MeV electron beam orbits a true circular trajectory of 1 m diameter. The computer control system developed for Aurora has a three-level hierarchical architecture. The top level is the Central Intelligence System, and the second an Autonomic Control System (ACS). The bottom is an assembly of distributed local controllers linked to the ACS level through optical fibers. This system provides fully automatic and remote operation, and a powerful machine study capability through the associated man--machine console and the interpretive operation language

  14. Computer control system of the superconducting SR-light source ``Aurora''

    Science.gov (United States)

    Yamada, Hironari

    1989-07-01

    The Aurora is a compact SR-light system optimized for x-ray lithography. The system includes a superconducting electron storage ring, a 150-MeV race track microtron as an injector, and light beamlines. The SR-ring features a single magnet body, in which the 650-MeV electron beam orbits a true circular trajectory of 1 m diameter. The computer control system developed for Aurora has a three-level hierarchical architecture. The top level is the Central Intelligence System, and the second an Autonomic Control System (ACS). The bottom is an assembly of distributed local controllers linked to the ACS level through optical fibers. This system provides fully automatic and remote operation, and a powerful machine study capability through the associated man-machine console and the interpretive operation language.

  15. Did Aboriginal Australians record a simultaneous eclipse and aurora in their oral traditions?

    Science.gov (United States)

    Fuller, Robert S.; Hamacher, Duane W.

    2017-12-01

    We investigate an Australian Aboriginal cultural story that seems to describe an extraordinary series of astronomical events occurring at the same time. We hypothesise that this was a witnessed natural event and explore natural phenomena that could account for the description. We select a thunderstorm, total solar eclipse, and strong Aurora Australis as the most likely candidates, then conclude a plausible date of 764 CE. We evaluate the different factors that would determine whether all these events could have been visible, include meteorological data, alternative total solar eclipse dates, solar activity cycles, aurorae appearances, and sky brightness during total solar eclipses. We conduct this study as a test-case for rigorously and systematically examining descriptions of rare natural phenomena in oral traditions, highlighting the difficulties and challenges with interpreting this type of hypothesis.

  16. A numerical solution of the coupled proton-H atom transport equations for the proton aurora

    International Nuclear Information System (INIS)

    Basu, B.; Jasperse, J.R.; Grossbard, N.J.

    1990-01-01

    A numerical code has been developed to solve the coupled proton-H atom linear transport equations for the proton aurora. The transport equations have been simplified by using plane-parallel geometry and the forward-scattering approximations only. Otherwise, the equations and their numerical solutions are exact. Results are presented for the particle fluxes and the energy deposition rates, and they are compared with the previous analytical results that were obtained by using additional simplifying approximations. It is found that although the analytical solutions for the particle fluxes differ somewhat from the numerical solutions, the energy deposition rates calculated by the two methods agree to within a few percent. The accurate particle fluxes given by the numerical code are useful for accurate calculation of the characteristic quantities of the proton aurora, such as the ionization rates and the emission rates

  17. Tightly coupled transient analysis of EBR-II: An INEL [Idaho National Engineering Laboratory] Engineering Simulation Center Project

    International Nuclear Information System (INIS)

    Makowitz, H.; Barber, D.G.; Dean, E.M.

    1989-01-01

    A ''Tightly Coupled'' transient analysis system for the Experimental Breeder Reactor-II (FBR-II) is presently under development. The system consists of a faster-than-real-time high fidelity reactor simulation, advanced graphics displays, expert system coupling, and real-time data coupling via the EBR-II data acquisition system to and from the plant and the control system. The first generation software has been developed and tested. Various subsystem couplings and the total system integration have been checked out. A ''Lightly Coupled'' EBR-II reactor startup was conducted in August of 1988 as a demonstration of the system. This system should enhance the diagnostic and prognostic capability of EBR-II in the near term and provide automatic control during startup and power maneuvering in the future, as well as serve as a testbed for new control system development for advanced reactors. 8 refs., 7 figs., 1 tab

  18. Modeling the energy deposition in the Aurora KrF laser amplifier chain

    International Nuclear Information System (INIS)

    Comly, J.C.; Czuchlewski, S.J.; Greene, D.P.; Hanson, D.E.; Krohn, B.J.; McCown, A.W.

    1988-01-01

    Monte Carlo calculations model the energy depositions by highly energetic electron beams into the cavities of the four KrF laser amplifiers in the Aurora chain. Deposited energy density distributions are presented and studied as functions of e-beam energy and gas pressure. Results are useful for analyzing small signal gain (SSG) measurements and optimizing deposition in future experiments. 7 refs., 7 figs., 1 tab

  19. Pulsating aurora and cosmic noise absorption associated with growth-phase arcs

    Directory of Open Access Journals (Sweden)

    D. McKay

    2018-01-01

    Full Text Available The initial stage of a magnetospheric substorm is the growth phase, which typically lasts 1–2 h. During the growth phase, an equatorward moving, east–west extended, optical auroral arc is observed. This is called a growth-phase arc. This work aims to characterize the optical emission and riometer absorption signatures associated with growth-phase arcs of isolated substorms. This is done using simultaneous all-sky camera and imaging riometer observations. The optical and riometric observations allow determination of the location of the precipitation within growth-phase arcs of low- (< 10  keV and high- (>  10 keV energy electrons, respectively. The observations indicate that growth-phase arcs have the following characteristics: 1. The peak of the cosmic noise absorption (CNA arc is equatorward of the optical emission arc. This CNA is contained within the region of diffuse aurora on the equatorward side.2. Optical pulsating aurora are seen in the border region between the diffuse emission region on the equatorward side and the bright growth-phase arc on the poleward side. CNA is detected in the same region. 3. There is no evidence of pulsations in the CNA. 4. Once the equatorward drift starts, it proceeds at constant speed, with uniform separation between the growth-phase arc and CNA of 40 ± 10 km. Optical pulsating aurora are known to be prominent in the post-onset phase of a substorm. The fact that pulsations are also seen in a fairly localized region during the growth phase shows that the substorm expansion-phase dynamics are not required to closely precede the pulsating aurora.

  20. Status of the Aurora laser system: Angular-multiplexed multikilojoule krypton fluoride prototype for inertial fusion

    International Nuclear Information System (INIS)

    Rosocha, L.A.; Goldstone, P.D.; Kristal, R.

    1986-01-01

    In this presentation, the authors report on the present status of the Aurora system including: The operation of the final stage 1-X 1-m laser at the 10-kJ level; the generation of 5-ns pulses by the front end; integration of the front end, multiplexer, amplifiers, and the extraction of long-pulse energy from the amplifier chain. Progress on the design and construction of the demultiplexer are also reported

  1. Shock aurora: Field-aligned discrete structures moving along the dawnside oval

    Science.gov (United States)

    Zhou, Xiaoyan; Haerendel, Gerhard; Moen, Jøran I.; Trondsen, Espen; Clausen, Lasse; Strangeway, Robert J.; Lybekk, Bjørn; Lorentzen, Dag A.

    2017-03-01

    Generated by interplanetary shocks or solar wind pressure pulses, shock aurora has transient, global, and dynamic significances and provides a direct manifestation of the solar wind-magnetosphere-ionosphere interaction. As a part of a series of studies of the shock aurora, this paper focuses on the interaction at the morning magnetopause and its auroral manifestation at 06 magnetic local time, where the velocity and magnetic field shears dominate the interaction. Flow shears can generate wave-like structures inside a viscous boundary layer or even larger-scale vortices. These structures couple to the ionosphere via quasi-static field-aligned currents or via kinetic Alfvén waves. Potential drops along field-aligned filaments may be generated accelerating electrons to form auroral manifestations of the structures. A shock aurora event at dawnside is used to test this scenario. The findings include moving auroral streaks/rays that have a vertical profile from red (at 250 km altitude) to purple (at 100 km). The streaks moved antisunward along the poleward boundary of the oval at an ionospheric speed of 3 km s-1. It was mapped to the magnetopause flank at 133 km s-1, which was consistent with the observed speed of the magnetopause surface waves generated by the Kelvin-Helmholtz instability. The calculated field-aligned potential drop using Haerendel's analytic model was 5 kV that reasonably explained the observations. The results support the above scenario and reveal that magnetic and velocity shears at the flanks of the magnetospause may be the main cause of the fast moving shock aurora streaks.

  2. Magnetospheric source region of discrete auroras inferred from their relationship with isotropy boundaries of energetic particles

    Directory of Open Access Journals (Sweden)

    A. G. Yahnin

    1997-08-01

    Full Text Available According to observations, the discrete auroral arcs can sometimes be found, either deep inside the auroral oval or at the poleward border of the wide (so-called double auroral oval, which map to very different regions of the magnetotail. To find common physical conditions for the auroral-arc generation in these magnetotail regions, we study the spatial relationship between the diffuse and discrete auroras and the isotropic boundaries (IBs of the precipitating energetic particles which can be used to characterise locally the equatorial magnetic field in the tail. From comparison of ground observation of auroral forms with meridional profiles of particle flux measured simultaneously by the low-altitude NOAA satellites above the ground observation region, we found that (1 discrete auroral arcs are always situated polewards from (or very close to the IB of >30-keV electrons, whereas (2 the IB of the >30-keV protons is often seen inside the diffuse aurora. These relationships hold true for both quiet and active (substorm conditions in the premidnight-nightside (18-01-h MLT sector considered. In some events the auroral arcs occupy a wide latitudinal range. The most equatorial of these arcs was found at the poleward edge of the diffuse auroras (but anyway in the vicinity of the electron IB, the most poleward arcs were simultaneously observed on the closed field lines near the polar-cap boundary. These observations disagree with the notion that the discrete aurora originate exclusively in the near-Earth portion of plasma sheet or exclusively on the PSBL field lines. Result (1 may imply a fundamental feature of auroral-arc formation: they originate in the current-sheet regions having very curved and tailward-stretched magnetic field lines.

  3. Ionospheric Electron Heating Associated With Pulsating Auroras: Joint Optical and PFISR Observations

    Science.gov (United States)

    Liang, Jun; Donovan, E.; Reimer, A.; Hampton, D.; Zou, S.; Varney, R.

    2018-05-01

    In a recent study, Liang et al. (2017, https://doi.org/10.1002/2017JA024127) repeatedly identified strong electron temperature (Te) enhancements when Swarm satellites traversed pulsating auroral patches. In this study, we use joint optical and Poker Flat Incoherent Scatter Radar (PFISR) observations to further investigate the F region plasma signatures related to pulsating auroras. On 19 March 2015 night, which contained multiple intervals of pulsating auroral activities, we identify a statistical trend, albeit not a one-to-one correspondence, of strong Te enhancements ( 500-1000 K) in the upper F region ionosphere during the passages of pulsating auroras over PFISR. On the other hand, there is no discernible and repeatable density enhancement in the upper F region during pulsating auroral intervals. Collocated optical and NOAA satellite observations suggest that the pulsating auroras are composed of energetic electron precipitation with characteristic energy >10 keV, which is inefficient in electron heating in the upper F region. Based upon PFISR observations and simulations from Liang et al. (2017) model, we propose that thermal conduction from the topside ionosphere, which is heated by precipitating low-energy electrons, offers the most likely explanation for the observed electron heating in the upper F region associated with pulsating auroras. Such a heating mechanism is similar to that underlying the "stable auroral red arcs" in the subauroral ionosphere. Our proposal conforms to the notion on the coexistence of an enhanced cold plasma population and the energetic electron precipitation, in magnetospheric flux tubes threading the pulsating auroral patch. In addition, we find a trend of enhanced ion upflows during pulsating auroral intervals.

  4. Possible Cause of Extremely Bright Aurora Witnessed in East Asia on 17 September 1770

    Science.gov (United States)

    Ebihara, Yusuke; Hayakawa, Hisashi; Iwahashi, Kiyomi; Tamazawa, Harufumi; Kawamura, Akito Davis; Isobe, Hiroaki

    2017-10-01

    Extremely bright aurora was witnessed in East Asia on 17 September 1770, according to historical documents. The aurora was described as "as bright as a night with full moon" at magnetic latitude of 25°. The aurora was dominated by red color extending from near the horizon up beyond the polar star (corresponding to elevation angle of 35°). We performed a two-stream electron transport code to calculate the volume emission rates at 557.7 nm (OI) and 630.0 nm (OI). Two types of distribution of precipitating electrons were assumed. The first one is based on the unusually intense electron flux measured by the DMSP satellite in the March 1989 storm. The distribution consists of hot (peaking at 3 keV) and cold (peaking at 71 eV) components. The second one is the same as the first one, but the hot component is removed. We call this high-intensity low-energy electrons (HILEEs). The first spectrum results in an auroral display with a bright, lower green border. The second one results in red-dominated aurora extending up to the elevation angle of 35° when the equatorward boundary of the electron precipitation is located at 32° invariant latitude. The poleward boundary of the precipitation would be 42° invariant latitude or greater to explain the auroral display extending from near the horizon. The origin of the HILEEs is probably the plasma sheet or the plasmasphere that is transported earthward to L 1.39 due to enhanced magnetospheric convection. Local heating or acceleration is also plausible.

  5. Integrating Felting in Elementary Science Classrooms to Facilitate Understanding of the Polar Auroras

    Directory of Open Access Journals (Sweden)

    Brandy Terrill

    2017-10-01

    Full Text Available The Next Generation Science Standards (NGSS emphasize conceptual science instruction that draws on students’ ability to make observations, explain natural phenomena, and examine concept relationships. This paper explores integrating the arts, in the form of felting, in elementary science classrooms as a way for students to model and demonstrate understanding of the complex scientific processes that cause the polar auroras. The steps for creating felting, and using the felting artwork students create for assessing science learning, are described.

  6. Aurora Research: Earth/Space Data Fusion Powered by GIS and Python

    Science.gov (United States)

    Kalb, V. L.; Collado-Vega, Y. M.; MacDonald, E.; Kosar, B.

    2017-12-01

    The Aurora Borealis and Australis Borealis are visually spectacular, but are also an indicator of Sun-magnetosphere-ionosphere energy transfer during geomagnetic storms. The Saint Patrick's Day Storm of 2015 is a stellar example of this, and is the focus of our study that utilizes the Geographical Information Services of ArcGIS to bring together diverse and cross disciplinary data for analysis. This research leverages data from a polar-orbiting Earth science sensor band that is exquisitely sensitive to visible light, namely the Day/Night Band (DNB) of the VIIRS instrument onboard the Suomi NPP satellite. This Sun-synchronous data source can provide high temporal and spatial resolution observations of the aurorae, which is not possible with current space science instruments. This data can be compared with auroral model data, solar wind measurements, and citizen science data of aurora observations and tweets. While the proposed data sources are diverse in type and format, their common attribute is location. This is exploited by bringing all the data into ArcGIS for mapping and analysis. The Python programming language is used extensively to automate the data preprocessing, group the DNB and citizen science observations to temporal windows associated with an auroral model timestep, and print the data to a pdf mapbook for sharing with team members. There are several goals for this study: compare the auroral model predictions with DNB data, look for fine-grained structure of the aurora in the DNB data, compare citizen science data with DNB values, and correlate DNB intensity with solar wind data. This study demonstrates the benefits of using a GIS platform to bring together data that is diverse in type and format for scientific exploration, and shows how Python can be used to scale up to large datasets.

  7. Technical realisation of the VISA-3 project, Parts I-II, Part I; Tehnicka realizacija projekta VISA-3, I-II deo, I Deo

    Energy Technology Data Exchange (ETDEWEB)

    Pavicevic, M; Smokovic, Z [Institute of Nuclear Sciences Boris Kidric, Odeljenje za reaktorsku eksperimentalnu tehniku, Vinca, Beograd (Serbia and Montenegro)

    1966-11-15

    This task is related to irradiation of reactor materials (steel, Al, MgO, Al{sub 2}O{sub 3}, ets.) at higher temperatures (200-500 deg C) in the fast neutron flux. These conditions would be more realistic to real reactor conditions than the conditions achieved within VISA-2 project. The experimental space will be the same as in VISA-2 project, i.e. refurbished reactor channels and within the fuel elements. The irradiation capsule will be leak tight with thermal isolation layer and supplied with electric heater to enable temperature variation.

  8. A compact SR light source for x-ray lithography 'AURORA'

    International Nuclear Information System (INIS)

    Toba, Y.

    1990-01-01

    A compact synchrotron radiation (SR) light source called AURORA has been developed for industrial use. It is specially designed for X-ray lithography. AURORA consists of a storage ring, injector microtron and SR light beam lines. The storage ring is a superconducting single magnet machine, designed to accelerate a 150 MeV electron beam to 650 MeV and to store as high as 300 mA current. The injector is a racetrack microtron (RTM) producing a pulsed 150 MeV beam. As many as 16 SR light beam channels are available for AURORA. Prototypes of the storage ring and RTM are constructed, and beam commissioning is performed. A hundred and fifty MeV electron beam of a pulsed current 10 μA from the RTM is successfully injected to the ring and accelerated to 600 MeV and 10 mA current stored with a lifetime of more than 20 hours. The half-integer method investigated is shown to work well with the injection efficiency being found to be very high. Improvement of the design is now under way. (N.K.)

  9. Observation of O+ (4P-4D0 lines in electron aurora over Svalbard

    Directory of Open Access Journals (Sweden)

    K. Throp

    2004-09-01

    Full Text Available This work reports on observations of O+ lines in aurora over Svalbard, Norway. The Spectrographic Imaging Facility measures auroral spectra in three wavelength intervals (Hβ, N+2 1N(0,2 and N+2 1N(1,3. The oxygen ion multiplet (4639-4696Å is blended with the band. It is found that in electron aurora, the brightness of this multiplet, is on average, about 0.1 of the total brightness. A joint optical and incoherent scatter radar study of an electron aurora event shows that the ratio is enhanced when the ionisation in the upper E-layer (140-190km is significant with respect to the E-layer peak below 130km. Rayed arcs were observed on one such occasion, whereas on other occasions the auroral intensity was below the threshold of the imager. A one-dimensional electron transport model is used to estimate the cross section for production of the multiplet in electron collisions, yielding 0.18x10-18cm2.

  10. Morphology and dynamics of aurora at fine scale: first results from the ASK instrument

    Directory of Open Access Journals (Sweden)

    H. Dahlgren

    2008-05-01

    Full Text Available The ASK instrument (Auroral Structure and Kinetics is a narrow field auroral imager, providing simultaneous images of aurora in three different spectral bands at multiple frames per second resolution. The three emission species studied are O2+ (5620 Å, O+ (7319 Å and O (7774 Å. ASK was installed and operated for the first time in an observational campaign on Svalbard, from December 2005 to March 2006. The measurements were supported by data from the Spectrographic Imaging Facility (SIF. The relation between the morphology and dynamics of the visible aurora and its spectral characteristics is studied for selected events from this period. In these events it is found that dynamic aurora is coupled to high energy electron precipitation. By studying the O2+/O intensity ratio we find that some auroral filaments are caused by higher energy precipitation within regions of lower energy precipitation, whereas other filaments are the result of a higher particle flux compared to the surroundings.

  11. Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis.

    Science.gov (United States)

    Chou, En-Ju; Hung, Liang-Yi; Tang, Chieh-Ju C; Hsu, Wen-Bin; Wu, Hsin-Yi; Liao, Pao-Chi; Tang, Tang K

    2016-03-29

    CPAP is required for centriole elongation during S/G2 phase, but the role of CPAP in mitosis is incompletely understood. Here, we show that CPAP maintains spindle pole integrity through its phosphorylation by Aurora-A during mitosis. Depletion of CPAP induced a prolonged delay in mitosis, pericentriolar material (PCM) dispersion, and multiple mitotic abnormalities. Further studies demonstrated that CPAP directly interacts with and is phosphorylated by Aurora-A at serine 467 during mitosis. Interestingly, the dispersal of the PCM was effectively rescued by ectopic expression of wild-type CPAP or a phospho-mimic CPAP-S467D mutant, but not a non-phosphorylated CPAP-S467A mutant. Finally, we found that CPAP-S467D has a low affinity for microtubule binding but a high affinity for PCM proteins. Together, our results support a model wherein CPAP is required for proper mitotic progression, and phosphorylation of CPAP by Aurora-A is essential for maintaining spindle pole integrity. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  12. The instantaneous relationship between polar cap and oval auroras at times of northward interplanetary magnetic field

    International Nuclear Information System (INIS)

    Murphree, J.S.; Anger, C.D.; Cogger, L.L.

    1982-01-01

    Optical images of the polar cap region at both 5577 and 3914 A obtained from 1400 km above the earth have been used to study the relationship between polar cap and oval aurora during periods when the interplanetary magnetic field is strongly northward, i.e., B > 3.5 nT. When this rather rare condition occurs, distinction between the two types of aurora is no longer as clear as depicted on the basis of statistical definitions of the auroral oval. Diffuse, weak emission can fill in the region between the auroral oval and discrete auroral features in the polar cap. The polar cap discrete features can appear very similar to auroral oval arcs in intensity, intensity ratio, and structure. Even more striking are the situations where discrete polar cap features merge with oval auroras. From this study it is concluded that under conditions of large positive B the region of closed magnetic field lines can expand poleward to occupy much of the high latitude region

  13. Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis

    Directory of Open Access Journals (Sweden)

    En-Ju Chou

    2016-03-01

    Full Text Available CPAP is required for centriole elongation during S/G2 phase, but the role of CPAP in mitosis is incompletely understood. Here, we show that CPAP maintains spindle pole integrity through its phosphorylation by Aurora-A during mitosis. Depletion of CPAP induced a prolonged delay in mitosis, pericentriolar material (PCM dispersion, and multiple mitotic abnormalities. Further studies demonstrated that CPAP directly interacts with and is phosphorylated by Aurora-A at serine 467 during mitosis. Interestingly, the dispersal of the PCM was effectively rescued by ectopic expression of wild-type CPAP or a phospho-mimic CPAP-S467D mutant, but not a non-phosphorylated CPAP-S467A mutant. Finally, we found that CPAP-S467D has a low affinity for microtubule binding but a high affinity for PCM proteins. Together, our results support a model wherein CPAP is required for proper mitotic progression, and phosphorylation of CPAP by Aurora-A is essential for maintaining spindle pole integrity.

  14. A 230 ka record of glacial and interglacial events from Aurora Cave, Fiordland, New Zealand

    International Nuclear Information System (INIS)

    Williams, P.W.

    1996-01-01

    Caves overrun by glaciers are known to accumulate dateable evidence of past glacial and interglacial events. Results are reported from an investigation of Aurora Cave on the slopes above Lake Te Anau in Fiordland. The cave commenced to form before c. 230 ka B.P. Sequences of glaciofluvial sediments interbedded with speleothems are evidence of the number and timing of glacial advances and the status of intervals between them. Twenty-six uranium series dates on speleothems underpin a chronology of seven glacial advances in the last 230 ka, with the peak of the late Otira glaciation, Aurora 3 advance, at c. 19 ka B.P. With five advances in the Otiran, the last glaciation is more complex than previously recognised. Comparison of the record with that recorded offshore from DSDP Site 594 reveals little matching, but the correspondence of the Aurora sequence with that interpreted from other onshore deposits is more convincing. Glacial deposits on slopes above the cave for a further 660 m may be evidence of the 'missing' glacial events of the mid-early Pleistocene. (author). 44 refs., 12 figs., 5 tabs

  15. Strong Solar Control of Infrared Aurora on Jupiter: Correlation Since the Last Solar Maximum

    Science.gov (United States)

    Kostiuk, T.; Livengood, T. A.; Hewagama, T.

    2009-01-01

    Polar aurorae in Jupiter's atmosphere radiate throughout the electromagnetic spectrum from X ray through mid-infrared (mid-IR, 5 - 20 micron wavelength). Voyager IRIS data and ground-based spectroscopic measurements of Jupiter's northern mid-IR aurora, acquired since 1982, reveal a correlation between auroral brightness and solar activity that has not been observed in Jovian aurora at other wavelengths. Over nearly three solar cycles, Jupiter auroral ethane emission brightness and solar 10.7 cm radio flux and sunspot number are positively correlated with high confidence. Ethane line emission intensity varies over tenfold between low and high solar activity periods. Detailed measurements have been made using the GSFC HIPWAC spectrometer at the NASA IRTF since the last solar maximum, following the mid-IR emission through the declining phase toward solar minimum. An even more convincing correlation with solar activity is evident in these data. Current analyses of these results will be described, including planned measurements on polar ethane line emission scheduled through the rise of the next solar maximum beginning in 2009, with a steep gradient to a maximum in 2012. This work is relevant to the Juno mission and to the development of the Europa Jupiter System Mission. Results of observations at the Infrared Telescope Facility (IRTF) operated by the University of Hawaii under Cooperative Agreement no. NCC5-538 with the National Aeronautics and Space Administration, Science Mission Directorate, Planetary Astronomy Program. This work was supported by the NASA Planetary Astronomy Program.

  16. Inventory of Federal energy-related environment and safety research for FY 1978. Volume II. Project listings and indexes

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-12-01

    This volume contains summaries of FY-1978 government-sponsored environment and safety research related to energy. Project summaries were collected by Aerospace Corporation under contract with the Department of Energy, Office of Program Coordination, under the Assistant Secretary for Environment. Summaries are arranged by log number, which groups the projects by reporting agency. The log number is a unique number assigned to each project from a block of numbers set aside for each agency. Information about the projects is included in the summary listings. This includes the project title, principal investigators, research organization, project number, contract number, supporting organization, funding level if known, related energy sources with numbers indicating percentages of effort devoted to each, and R and D categories. A brief description of each project is given, and this is followed by subject index terms that were assigned for computer searching and for generating the printed subject index in Volume IV.

  17. Inventory of Federal energy-related environment and safety research for FY 1978. Volume II. Project listings and indexes

    International Nuclear Information System (INIS)

    1979-12-01

    This volume contains summaries of FY-1978 government-sponsored environment and safety research related to energy. Project summaries were collected by Aerospace Corporation under contract with the Department of Energy, Office of Program Coordination, under the Assistant Secretary for Environment. Summaries are arranged by log number, which groups the projects by reporting agency. The log number is a unique number assigned to each project from a block of numbers set aside for each agency. Information about the projects is included in the summary listings. This includes the project title, principal investigators, research organization, project number, contract number, supporting organization, funding level if known, related energy sources with numbers indicating percentages of effort devoted to each, and R and D categories. A brief description of each project is given, and this is followed by subject index terms that were assigned for computer searching and for generating the printed subject index in Volume IV

  18. Caltrans WeatherShare Phase II System: An Application of Systems and Software Engineering Process to Project Development

    Science.gov (United States)

    2009-08-25

    In cooperation with the California Department of Transportation, Montana State University's Western Transportation Institute has developed the WeatherShare Phase II system by applying Systems Engineering and Software Engineering processes. The system...

  19. The FERRUM project: an extremely long radiative lifetime in Ti II measured in an ion storage ring

    International Nuclear Information System (INIS)

    Hartman, H; Rostohar, D; Derkatch, A; Lundin, P; Schef, P; Johansson, S; Lundberg, H; Mannervik, S; Norlin, L-O; Royen, P

    2003-01-01

    We have extended the laser probing technique at the CRYRING storage ring to measurement of the extremely long lifetime (28 s) of the metastable 3d 2 ( 3 P)4s b 4 P 5/2 level in Ti II. The result obtained demonstrates the power of this method for investigation of such long-lived levels. This is the first experimental lifetime investigation of metastable states in Ti II. (letter to the editor)

  20. First Joint Observations of Radio Aurora by the VHF and HF Radars of the ISTP SB RAS

    Science.gov (United States)

    Berngardt, O. I.; Lebedev, V. P.; Kutelev, K. A.; Kushnarev, D. S.; Grkovich, K. V.

    2018-01-01

    Two modern radars for diagnosis of the ionosphere by the radio-wave backscattering method, namely, the Irkutsk incoherent scatter radar at VHF (IISR, 154-162 MHz) and the Ekaterinburg coherent radar at HF (EKB, 8-20 MHz) are operated at the Institute of Solar-Terrestrial Physics, Siberian Branch of the Russian Academy of Sciences (ISTP SB RAS). The paper analyzes the results of joint observations of strong scattering (radio aurora) on June 8, 2015. To determine the geographical position of the radio aurora, we developed original methods that take into account both the features of the radio-wave propagation and the features of the radar antenna systems. It is shown that there are areas where the spatial position of the HF and VHF radio aurora can coincide. This permits using the radars as a single complex for diagnosis of the characteristics of small-scale high-latitude irregularities in the ionospheric E and F layers. A comparative analysis of the characteristics and temporal dynamics of the radio-aurora region in the HF and VHF ranges is performed. Using the DMSP satellite data, it has been shown that the radio aurora dynamics during this experiment with the EKB radar can be related with the spatial dynamics of the localized area with high electric field, which moves from high to equatorial latitudes. It is found that due to the broader field of view, radio aurora at the HF radar was stably observed 6-12 min earlier than at the VHF radar. This permits using the EKB radar data for prediction of the radio-aurora detection by the IISR radar.

  1. Characterization of a Pyrazolo[4,3-d]pyrimidine Inhibitor of Cyclin-dependent Kinases 2 and 5 and Aurora A With Pro-Apoptotic and Anti-Angiogenic Activity In Vitro

    Czech Academy of Sciences Publication Activity Database

    Řezníčková, Eva; Weitensteiner, S.; Havlíček, Libor; Jorda, Radek; Gucký, Tomáš; Berka, K.; Bazgier, Václav; Zahler, S.; Kryštof, Vladimír; Strnad, Miroslav

    2015-01-01

    Roč. 86, č. 6 (2015), s. 1528-1540 ISSN 1747-0277 R&D Projects: GA ČR GAP305/12/0783; GA ČR GA14-19590S; GA MŠk(CZ) LO1204 Institutional support: RVO:61389030 Keywords : angiogenesis * apoptosis * aurora A Subject RIV: CE - Biochemistry Impact factor: 2.802, year: 2015 http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=CCC&DestLinkType=FullRecord&UT=000367376800022

  2. Electricity from photovoltaic solar cells: Flat-Plate Solar Array Project final Report. Volume II: Silicon material

    OpenAIRE

    Lutwack, R.

    1986-01-01

    The Flat-Plate Solar Array (FSA) Project, funded by the U.S. Government and managed by the Jet Propulsion Laboratory, was formed in 1975 to develop the module/array technology needed to attain widespread terrestrial use of photovoltaics by 1985. To accomplish this, the FSA Project established and managed an Industry, University, and Federal Government Team to perform the needed research and development. The goal of the Silicon Material Task, a part of the FSA Project, was to develop and ...

  3. Fuel Modelling at Extended Burnup (Fumex-II). Report of a Coordinated Research Project 2002-2007

    International Nuclear Information System (INIS)

    2012-08-01

    to fuel licensing. This report describes the results of the coordinated research project on fuel modelling at extended burnup (FUMEX-II). This programme was initiated in 2000 and completed in 2006. It followed previous programmes on fuel modelling, D-COM which was conducted between 1982 and 1984, and the FUMEX programme which was conducted between 1993 and 1996. The participants used a mixture of data, derived from actual irradiation histories, in particular those with PIE measurements from high burnup commercial and experimental fuels, combined with idealized power histories intended to represent possible future extended dwell, commercial irradiations, to test code capabilities at high burnup. All participants have carried out calculations on the six priority cases selected from the 27 cases identified to them at the first research coordination meeting (RCM). At the second RCM, three further priority cases were identified and have been modelled. These priority cases have been chosen as the best available to help determine which of the many high burnup models used in the codes best reflect reality. The participants are using the remaining cases for verification and validation purposes as well as inter-code comparisons. The codes participating in the exercise have been developed for a wide variety of purposes, including predictions for fuel operation in PWR, BWR, WWER, the pressurized HWR type, CANDU and other reactor types. They are used as development tools as well as for routine licensing calculations, where code configuration is strictly controlled.

  4. The AquaDEB project: Physiological flexibility of aquatic animals analysed with a generic dynamic energy budget model (phase II).

    NARCIS (Netherlands)

    Alunno-Bruscia, M.; v.d. Veer, H.; Kooijman, S.A.L.M.

    2011-01-01

    This second special issue of the Journal of Sea Research on development and applications of Dynamic Energy Budget (DEB) theory concludes the European Research Project AquaDEB (2007-2011). In this introductory paper we summarise the progress made during the running time of this 5. years' project,

  5. Inventory of Federal energy-related environment and safety research for FY 1979. Volume II. Project listings and indexes

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-12-01

    This volume contains summaries of FY 1979 government-sponsored environment and safety research related to energy arranged by log number, which groups the projects by reporting agency. The log number is a unique number assigned to each project from a block of numbers set aside for each contributing agency. Information elements included in the summary listings are project title, principal investigators, research organization, project number, contract number, supporting organization, funding level, related energy sources with numbers indicating percentages of effort devoted to each, and R and D categories. A brief description of each project is given, and this is followed by subject index terms that were assigned for computer searching and for generating the printed subject index in the back of this volume.

  6. Inventory of Federal energy-related environment and safety research for FY 1979. Volume II. Project listings and indexes

    International Nuclear Information System (INIS)

    1980-12-01

    This volume contains summaries of FY 1979 government-sponsored environment and safety research related to energy arranged by log number, which groups the projects by reporting agency. The log number is a unique number assigned to each project from a block of numbers set aside for each contributing agency. Information elements included in the summary listings are project title, principal investigators, research organization, project number, contract number, supporting organization, funding level, related energy sources with numbers indicating percentages of effort devoted to each, and R and D categories. A brief description of each project is given, and this is followed by subject index terms that were assigned for computer searching and for generating the printed subject index in the back of this volume

  7. Preparation of C-II labeled pyruvic acid for use in assessment of hypoxia in tumors. Project 4

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    Of the three methods of synthesis of C-II-labeled pyruvic acid that we had proposed to investigate in order to determine the best and most appropriate synthesis of C-II-labeled pyruvate, the cold chemistry of Method A, via an isocyanide intermediate, has been verified. Similarly, the cold chemistry of Method B, via the 1,3-dithiane derivative, has been verified up to the deprotection and last step of the synthesis. The difficulties which have been encountered with the biochemistry of Method C from ribulose 1,5-diphosphate, have yet to be resolved. 12 refs., 6 figs

  8. The MET/AXL/FGFR Inhibitor S49076 Impairs Aurora B Activity and Improves the Antitumor Efficacy of Radiotherapy.

    Science.gov (United States)

    Clémenson, Céline; Chargari, Cyrus; Liu, Winchygn; Mondini, Michele; Ferté, Charles; Burbridge, Mike F; Cattan, Valérie; Jacquet-Bescond, Anne; Deutsch, Eric

    2017-10-01

    Several therapeutic agents targeting HGF/MET signaling are under clinical development as single agents or in combination, notably with anti-EGFR therapies in non-small cell lung cancer (NSCLC). However, despite increasing data supporting a link between MET, irradiation, and cancer progression, no data regarding the combination of MET-targeting agents and radiotherapy are available from the clinic. S49076 is an oral ATP-competitive inhibitor of MET, AXL, and FGFR1-3 receptors that is currently in phase I/II clinical trials in combination with gefitinib in NSCLC patients whose tumors show resistance to EGFR inhibitors. Here, we studied the impact of S49076 on MET signaling, cell proliferation, and clonogenic survival in MET-dependent (GTL16 and U87-MG) and MET-independent (H441, H460, and A549) cells. Our data show that S49076 exerts its cytotoxic activity at low doses on MET-dependent cells through MET inhibition, whereas it inhibits growth of MET-independent cells at higher but clinically relevant doses by targeting Aurora B. Furthermore, we found that S49076 improves the antitumor efficacy of radiotherapy in both MET-dependent and MET-independent cell lines in vitro and in subcutaneous and orthotopic tumor models in vivo In conclusion, our study demonstrates that S49076 has dual antitumor activity and can be used in combination with radiotherapy for the treatment of both MET-dependent and MET-independent tumors. These results support the evaluation of combined treatment of S49076 with radiation in clinical trials without patient selection based on the tumor MET dependency status. Mol Cancer Ther; 16(10); 2107-19. ©2017 AACR . ©2017 American Association for Cancer Research.

  9. R. B. Cunninghame Graham’s “Aurora La Cujiñi” (1898 : An Exploration / Aurora La Cujiñi” (1898 de R. B. Cunninghame Graham - Una indagación

    Directory of Open Access Journals (Sweden)

    John C. Mc Intyre

    2011-06-01

    Full Text Available Abstract: In Aurora La Cujiñi-A realistic sketch in Seville, published by the Scottish writer R. B. Cunninghame Graham in 1898, the frontispiece showed the sepia image of a female flamenco dancer. What might ‘La Cujiñi’ mean? Charles Davillier and Gustave Doré in 1862-63 note the existence of a Sevillan dancer with this name. In 2011 the present writer was gifted an old lithograph, in colour, published in Seville ‘c. 1850’ and entitled ‘Aurora La Cujiñí’ - with ñ and í. The two images are supplied. ‘Aurora La Cujiñi’ really existed. Graham’s sketch has five phases: Seville; the bullfight; the crowd’s return to town; a low-quality flamenco show; and the highly stirring performance by an initially anonymous female dancer - the dead Aurora brought back to life. Graham emphasises the Seville blend of blood and sensuality in a realist style also capable of mockery and criticism. Graham’s writing includes a good variety of well-controlled Spanish vocabulary, his empathy with horses and a deep nostalgia for times past. W. H. Hudson, writer and friend of Graham, in 1894 recommended that Graham should read the Argentine sketches published by Alfred Ébélot in 1890. In Aurora La Cujiñi Graham in 1898 is beginning to show mastery of the literary sketch. Question: Might Lorca have read Aurora La Cujiñi before drafting “Teoría y juego del duende”? Resumen: En Aurora La Cujiñi-A realistic sketch in Seville (1898 del escritor escocés R. B. Cunninghame Graham, el frontispicio llevaba la imagen en sepia de una bailadora de flamenco. ¿Qué podría significar ‘La Cujiñi’? Charles Davillier y Gustave Doré en 1862-1863 apuntan la existencia de una bailaora sevillana con este nombre. En 2011 al que esto escribe le regalaron una litografía antigua, en color, publicada en Sevilla ‘hacia 1850’ e intitulada ‘Aurora la Cujiñí’ - con ñ y con í. Se incluyen las dos imágenes. ‘Aurora La Cujiñi’ realmente

  10. Aurorae, sunspots and weather, mainly since A.D. 1200

    International Nuclear Information System (INIS)

    Schove, D.J.

    1981-01-01

    Auroral records recieved for the Spectrum of Time project were used in 1955 to estimate sunspot activity and the dates maxima and minima back to 649 B.C. An additional set of rules has been developed and has made possible further improvements utilizing the separate auroral maxima associated with flares and coronal holes on the sun. A further set can now be given. 1) The time between sunspot maxima depends especially on the ratio of the amplitudes: the time between minima is high if the next cycle is very weak and low when the two consecutive cycles are both strong. 2) The time of rise is usually dependent on the strength of the next maxima, and the time of fall is low when a moderate cycle is followed by a strong one. (orig./WL)

  11. Results of a Survey Software Development Project Management in the U.S. Aerospace Industry. Volume II. Project Management Techniques, Procedures and Tools.

    Science.gov (United States)

    1979-12-18

    I Z I UO W-1 eu 0 - 0 tD CL 0, 0 -I7 NW 2 - x M.j a CL W2 X 41 a ~ 0 0,a 4~~ 0 Z .D .J 0 2. N 0 ~N IU 0 4 - 2 0 ~. 0 Q. ’o ~ 0, 𔃺e U - U ~- 0, 0 -a...0 .44 A A A Ao 0 - 2. -U 2- 4’ A 4’ A o .~ 0 .~ 2. flJ 2. A Ao ~. a 2. 𔃾 2- @2 @2 @2 A 0 .~. a I- 2. Xii - 0 2 @2 ON AXe Re 2- Oi. K A.. A A AU .40...Project manager or person appointed by him SE/ TD project manager b. Senior ADP Manager Director Director computer programming Software program design

  12. Solent Disturbance and Mitigation Project Phase II: Predicting the impact of human disturbance on overwintering birds in the Solent.

    OpenAIRE

    Stillman, Richard A.; West, Andrew D.; Clarke, Ralph T.; Liley, D.

    2012-01-01

    The Solent coastline provides feeding grounds for internationally protected populations of overwintering waders and wildfowl, and is also extensively used for recreation. In response to concerns over the impact of recreational pressure on birds within protected areas in the Solent, the Solent Forum initiated the Solent Disturbance and Mitigation Project to determine visitor access patterns around the coast and how their activities may influence the birds. The project has been divided into two...

  13. The AquaDEB project: Physiological flexibility of aquatic animals analysed with a generic dynamic energy budget model (phase II)

    OpenAIRE

    Alunno-bruscia, Marianne; Van Der Veer, Henk; Kooijman, S. A. L. M.

    2011-01-01

    This second special issue of the Journal of Sea Research on development and applications of Dynamic Energy Budget (DEB) theory concludes the European Research Project AquaDEB (2007–2011). In this introductory paper we summarise the progress made during the running time of this 5 years’ project, present context for the papers in this volume and discuss future directions. The main scientific objectives in AquaDEB were (i) to study and compare the sensitivity of aquatic species (mainly molluscs ...

  14. Optical observations of Magnetosphere-Ionosphere coupling: Inter-hemispheric electron reflections within pulsating aurora

    Science.gov (United States)

    Samara, M.; Michell, R.; Khazanov, G. V.; Grubbs, G. A., II

    2017-12-01

    Magnetosphere-Ionosphere coupling is exhibited in reflected primary and secondary electrons which constitute the second step in the formation of the total precipitating electron distribution. While they have largely been missing from the current theoretical studies of particle precipitation, ground based observations point to the existence of a reflected electron population. We present evidence that pulsating aurora is caused by electrons bouncing back and forth between the two hemispheres. This means that these electrons are responsible for some of the total light in the aurora, a possibility that has largely been ignored in theoretical models. Pulsating auroral events imaged optically at high time resolution present direct observational evidence in agreement with the inter-hemispheric electron bouncing predicted by the SuperThermal Electron Trans-port (STET) model. Immediately following each of the `pulsation-on' times are equally spaced, and subsequently fainter pulsations, which can be explained by the primary precipitating electrons reflecting upwards from the ionosphere, traveling to the opposite hemisphere, and reflecting upwards again. The high time-resolution of these data, combined with the short duration of the `pulsation-on' time ( 1 s) and the relatively long spacing between pulsations ( 6 to 9 s) made it possible to observe the faint optical pulses caused by the reflected electrons coming from the opposite hemisphere. These results are significant and have broad implications because they highlight that the formation of the auroral electron distributions within regions of diffuse and pulsating aurora contain contributions from reflected primary and secondary electrons. These processes can ultimately lead to larger fluxes than expected when considering only the primary injection of magnetospheric electrons.

  15. Simultaneous measurement of aurora-related, irregular magnetic pulsations at northern and southern high latitudes

    International Nuclear Information System (INIS)

    Arnoldy, R.L.; Rajashekar, R.; Cahill, L.J. Jr.; Engebretson, M.J.; Rosenberg, T.J.; Mende, S.B.

    1987-01-01

    A dominant feature of high-latitude magnetic pulsations is large-amplitude irregular pulsations (Pi) which are closely correlated with the movement of the observing station under particle precipitation, producing the dayside auroral and the high-latitude expansion of nightside aurora. The dayside Pi-1 pulsation maximum centered about local magnetic noon has no strong seasonal dependence, indicating that the dayside aurora illuminates both hemispheres independent of the latitude of the subsolar point. The summer noon pulsation maximum has, however, a greater longitudinal extent than the winter noon maximum, as measured at 74 degree-75 degree invariant latitude. The nightside magnetic pulsations are bursts of Pi (PiB) having an average duration of 15 min. From Defense Meteorological Satellite Program photos the auroral forms related to the high-latitude PiB can be identified as the poleward discrete arc generally having a large longitudinal extent. If the auroral forms are very similar in both hemispheres, then the large longitudinal extent coupled with movement of the auroral could explain why 85% of the PiB events have onsets within 10 min at opposite hemisphere sites (South Pole, Antarctica, and Sondre Stromfjord, Greenland) separated in local magnetic time by about 1.5 hours. There is no seasonal dependence in the statistical occurrence of PiB, nor in its simultaneity in opposite hemispheres. Apparently, the seasonal distortion of the tail plasma sheet has little effect on the acceleration of high-latitude auroral beams. The actual several minute time difference in opposite hemisphere onsets of PiB is probably due to the westward/poleward motion of the longitudinally extended aurora

  16. The aurora at quite magnetospheric conditions: Repeatability and dipole tilt angle dependence

    International Nuclear Information System (INIS)

    Oznovich, I.; Eastes, R.W.; Huffman, R.E.; Tur, M.; Glaser, I.

    1993-01-01

    Is there a magnetospheric ground state? Do the position and size of the auroral oval depend on the magnetic dipole tilt angle at quiet magnetospheric conditions? In order to address these questions, northern hemisphere images of the aurora at 1356 Angstrom, obtained by Polar BEAR at solar minimum (beginning of 1987), were related to high temporal resolution IPM 8 measurements of the interplanetary magnetic field, to solar wind velocity, and to the ground-based activity index Kp. The first problem was addressed by a two-dimensional correlation study of the repeatability of auroral emissions in corrected geomagnetic space at conditions of minimum energy transfer from the magnetosphere. The correlation measure of auroral images was 0.6-0.85. Error simulations indicate that given the uncertainties in pixel position and intensity, the maximum expected value of the correlation measure is 0.65-0.9. The notion of a ground state magnetosphere is therefore supported by this data. Repeatability was found at the same level regardless of time or reconfigurations of the magnetosphere between images and independent of magnetic time sector. The second problem was addressed by relating latitudinal shifts of the aurora with dipole tilt angle without resorting to auroral boundary specification. This data indicate that the latitude of the continuous aurora is related to the dipole tilt angle at quiet magnetospheric conditions. In the winter hemisphere a 10 degrees increase in the dipole tilt angle causes a 1 degree decrease (increase) in the latitude of auroral emissions at noon (midnight). The magnetic local time distribution of the latitudinal shifts with dipole tilt angle support a simple model in which the dipole tilt angle determines the position of the center of the auroral circle along the magnetic meridian 1320-0120 MLT (for IMF B y positive) and does not affect its radius. 22 refs., 8 figs

  17. On the variability of I(7620 Å/I(5577 Å in low altitude aurora

    Directory of Open Access Journals (Sweden)

    E. J. Llewellyn

    1999-07-01

    Full Text Available An auroral electron excitation model, combined with simple equilibrium neutral and ion chemistry models, is used to investigate the optical emission processes and height profiles of I(5577 Å and I(7620 Å in the 90 to 100 km altitude region. It is shown that the apparent discrepancies between ground-based and rocket-borne auroral observations of the I(7620 Å/I(5577 Å ratio are due to the extreme height variation of this intensity ratio in the 90 to 100 km region.Key words. Atmospheric composition and structure (airglow and aurora

  18. Indole Alkaloids from the Sea Anemone Heteractis aurora and Homarine from Octopus cyanea.

    Science.gov (United States)

    Shaker, Kamel H; Göhl, Matthias; Müller, Tobias; Seifert, Karlheinz

    2015-11-01

    The two new indole alkaloids 2-amino-1,5-dihydro-5-(1H-indol-3-ylmethyl)-4H-imidazol-4-one (1), 2-amino-5-[(6-bromo-1H-indol-3-yl)methyl]-3,5-dihydro-3-methyl-4H-imidazol-4-one (2), and auramine (3) have been isolated from the sea anemone Heteractis aurora. Both indole alkaloids were synthesized for the confirmation of the structures. Homarine (4), along with uracil (5), hypoxanthine (6), and inosine (7) have been obtained from Octopus cyanea. Copyright © 2015 Verlag Helvetica Chimica Acta AG, Zürich.

  19. On the variability of I(7620 Å/I(5577 Å in low altitude aurora

    Directory of Open Access Journals (Sweden)

    E. J. Llewellyn

    Full Text Available An auroral electron excitation model, combined with simple equilibrium neutral and ion chemistry models, is used to investigate the optical emission processes and height profiles of I(5577 Å and I(7620 Å in the 90 to 100 km altitude region. It is shown that the apparent discrepancies between ground-based and rocket-borne auroral observations of the I(7620 Å/I(5577 Å ratio are due to the extreme height variation of this intensity ratio in the 90 to 100 km region.

    Key words. Atmospheric composition and structure (airglow and aurora

  20. High Resolution Air Quality Forecasts in the Western Mediterranean area within the MACC, MACC-II and MACC-III European projects

    Energy Technology Data Exchange (ETDEWEB)

    Cansado, A.; Martinez, I.; Morales, T.

    2015-07-01

    The European Earth observation programme Copernicus, formerly known as GMES (Global Monitoring for Environment and Security) is establishing a core global and regional environmental atmospheric service as a component of the Europes Copernicus/GMES initiative through successive R and D projects led by ECMWF (European Center for Medium-range Weather Forecasting) and funded by the 6th and 7th European Framework Programme for Research and Horizon 2020 Programme: GEMS, MACC, MACC-II and MACC-III. AEMET (Spanish State Meteorological Agency) has participated in the projects MACC and MACC-II and continues participating in MACC-III (http://atmosphere.copernicus.eu). AEMET has contributed to those projects by generating highresolution (0.05 degrees) daily air-quality forecasts for the Western Mediterranean up to 48 hours aiming to analyse the dependence of the quality of forecasts on resolution. We monitor the evolution of different chemical species such as NO{sub 2}, O{sub 3}, CO y SO{sub 2} at surface and different vertical levels using the global model MOCAGE and the MACC Regional Ensemble forecasts as chemical boundary conditions. We will show different case-studies, where the considered chemical species present high values and will show a validation of the air-quality by comparing to some of the available air-quality observations (EMEP/GAW, regional -autonomous communities- and local -city councils- air-quality monitoring networks) over the forecast domain. The aim of our participation in these projects is helping to improve the understanding of the processes involved in the air-quality forecast in the Mediterranean where special factors such as highly populated areas together with an intense solar radiation make air-quality forecasting particularly challenging. (Author)

  1. High Resolution Air Quality Forecasts in the Western Mediterranean area within the MACC, MACC-II and MACC-III European projects

    Energy Technology Data Exchange (ETDEWEB)

    Cansado, A.; Martinez, I.; Morales, T.

    2015-07-01

    The European Earth observation programme Copernicus, formerly known as GMES (Global Monitoring for Environment and Security) is establishing a core global and regional environmental atmospheric service as a component of the Europe’s Copernicus/GMES initiative through successive R&D projects led by ECMWF (European Center for Medium-range Weather Forecasting) and funded by the 6th and 7th European Framework Programme for Research and Horizon 2020 Programme: GEMS, MACC, MACC-II and MACC-III. AEMET (Spanish State Meteorological Agency) has participated in the projects MACC and MACC-II and continues participating in MACC-III (http://atmosphere.copernicus.eu). AEMET has contributed to those projects by generating highresolution (0.05 degrees) daily air-quality forecasts for the Western Mediterranean up to 48 hours aiming to analyse the dependence of the quality of forecasts on resolution. We monitor the evolution of different chemical species such as NO2, O3, CO y SO2 at surface and different vertical levels using the global model MOCAGE and the MACC Regional Ensemble forecasts as chemical boundary conditions. We will show different case-studies, where the considered chemical species present high values and will show a validation of the air-quality by comparing to some of the available air-quality observations (EMEP/GAW, regional -autonomous communities- and local -city councils- air-quality monitoring networks) over the forecast domain. The aim of our participation in these projects is helping to improve the understanding of the processes involved in the air-quality forecast in the Mediterranean where special factors such as highly populated areas together with an intense solar radiation make air-quality forecasting particularly challenging. (Author)

  2. Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required For Mitotic ATM Activation and the Spindle Checkpoint

    OpenAIRE

    Yang, Chunying; Tang, Xi; Guo, Xiaojing; Niikura, Yohei; Kitagawa, Katsumi; Cui, Kemi; Wong, Stephen T.C.; Fu, Li; Xu, Bo

    2011-01-01

    The ATM kinase plays a critical role in the maintenance of genetic stability. ATM is activated in response to DNA damage and is essential for cell cycle checkpoints. Here, we report that ATM is activated in mitosis in the absence of DNA damage. We demonstrate that mitotic ATM activation is dependent on the Aurora-B kinase and that Aurora-B phosphorylates ATM on serine 1403. This phosphorylation event is required for mitotic ATM activation. Further, we show that loss of ATM function results in...

  3. Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

    Directory of Open Access Journals (Sweden)

    Schillaci Tiziana

    2007-11-01

    Full Text Available Abstract Background Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN. CIN is characterized by chromosomal aberrations, gains or losses of whole chromosomes (aneuploidy, and it is often associated with centrosome amplification. Centrosomes control cell division by forming a bipolar mitotic spindle and play an essential role in the maintenance of chromosomal stability. However, whether centrosome amplification could directly cause aneuploidy is not fully established. Also, alterations in genes required for mitotic progression could be involved in CIN. A major candidate is represented by Aurora-A/STK15 that associates with centrosomes and is overexpressed in several types of human tumour. Methods Centrosome amplification were induced by hydroxyurea treatment and visualized by immunofluorescence microscopy. Aurora-A/STK15 ectopic expression was achieved by retroviral infection and puromycin selection in HCT116 tumour cells. Effects of Aurora-A/STK15 depletion on centrosome status and ploidy were determined by Aurora-A/STK15 transcriptional silencing by RNA interference. Changes in the expression levels of some mitotic genes were determined by Real time RT-PCR. Results We investigated whether amplification of centrosomes and overexpression of Aurora-A/STK15 induce CIN using as a model system a colon carcinoma cell line (HCT116. We found that in HCT116 cells, chromosomally stable and near diploid cells harbouring a MIN phenotype, centrosome amplification induced by hydroxyurea treatment is neither maintained nor induces aneuploidy. On the contrary, ectopic overexpression of Aurora-A/STK15 induced supernumerary centrosomes and aneuploidy. Aurora-A/STK15 transcriptional silencing by RNA interference in cells ectopically overexpressing this kinase promptly decreased cell numbers with supernumerary centrosomes and aneuploidy. Conclusion Our

  4. Progress and results of the project ENETRAP II: European network of education and training in radiation protection

    International Nuclear Information System (INIS)

    Marco, M.; Llorente Herranz, C.; Coeck, M.; Livosi, P.; Massiot, P.; Moebius, S.

    2013-01-01

    The CIEMAT has participated in a number of working groups and has led the WP 6 for the creation of a database of events of specific training the RPE and the RPO taking into account aspects developed in schemes of defined training. The database includes providers and job training opportunities. Is a tool that will serve as a mechanism for comparison with established standards of training in the project.The project has made great progress in the implementation of the new directive at European level. (Author)

  5. Spinning cylinder experiments SC-I and SC-II: A review of results and analyses provided to the FALSIRE project

    International Nuclear Information System (INIS)

    Morland, E.; Sherry, A.H.

    1993-01-01

    A series of six large-scale experiments have been carried out at AEA Technology using the Spinning Cylinder test facility. Results from two of those experiments (SC-I and SC-II) have been provided to Project FALSIRE and are reviewed in this paper. The Spinning Cylinder tests were carried out using hollow cylinders of 1.4m outer diameter, 0.2m wall thickness and 1.3m length, containing full-length axial defects and fabricated from a modified A508 Class 3 steel. The first Spinning Cylinder test (SC-I) was an investigation of stable ductile growth induced via mechanical (primary) loading and under conditions of contained yielding. Mechanical loading was provided in the hoop direction by rotating the cylinder about its major axis within an enclosed oven. The second test (SC-II) investigated stable ductile growth under severe thermal shock (secondary) loading again under conditions of contained yielding. In this case thermal shock was produced by spraying cold water on the inside surface of the heated cylinder whilst it was rotating. For each experiment, results are presented in terms of a number of variables, eg. crack growth, temperature, stress, strain and applied K and J. In addition, an overview of the analyses of the FALSIRE Phase-1 report is also presented with respect to test SC-I and SC-II. 4 refs., 14 figs., 13 tabs

  6. Commercial disposal of high integrity containers (HICs) containing EPICOR-II prefilters from Three Mile Island: Reflections and projections

    International Nuclear Information System (INIS)

    McConnell, J.W. Jr.; Schmitt, R.C.

    1986-09-01

    The processes of loading, transporting, and commerically disposing of 46 EPICOR-II prefilters, each contained in a High Integrity Container (HIC), are described. Also described are participation of the regulatory agencies and industrial organizations in combining their efforts to accomplish this task. The significant aspect of the task was that the commerical disposal involved the first-of-a-kind production use of a reinforced concrete HIC at the US Ecology, Inc., facility in the State of Washington. The same type of container probably can be used in below- or above-ground disposal of other types of high specific activity, low-level nuclear wastes. 14 refs., 4 figs

  7. Precipitation of relativistic electrons of the Van Allen belts into the proton aurora

    International Nuclear Information System (INIS)

    Jordanova, Vania K.; Miyoshi, Y.; Sakaguchi, K.; Shiokawa, K.; Evans, D.S.; Albert, Jay; Connors, M

    2008-01-01

    The Van Allen electron belts consist of two regions encircling the earth in which relativistic electrons are trapped in the earth's magnetic field. Populations of relativistic electrons in the Van Allen belts vary greatly with geomagnetic disturbance and they are a major source of damage to space vehicles. In order to know when and by how much these populations of relativistic electrons increase, it is important to elucidate not only the cause of acceleration of relativistic electrons but also the cause of their loss from the Van Allen belts. Here we show the first evidence that left-hand polarized electromagnetic ion cyclotron (EMIC) plasma waves can cause the loss of relativistic electrons into the atmosphere, on the basis of results of an excellent set of ground and satellite observations showing coincident precipitation of ions with energies of tens of keV and of relativistic electrons into an isolated proton aurora. The proton aurora was produced by precipitation of ions with energies of tens of keV due to EMIC waves near the plasma pause, which is a manifestation of wave-particle interactions. These observations clarify that ions with energies of tens of keV affect the evolution of relativistic electrons in the Van Allen belts via parasitic resonance with EMIC waves, an effect that was first theoretically predicted in the early 1970's

  8. Improved performance of the Aurora KrF/ICF laser system

    International Nuclear Information System (INIS)

    Jones, J.E.; Czuchlewski, S.J.; Turner, T.P.; Watt, R.G.; Thomas, S.J.; Netz, D.A.; Tallman, C.R.; Figueira, J.F.

    1990-01-01

    This paper reports on Aurora the Los Alamos National Laboratory short pulse high power krypton-fluoride laser system. It serves as an end-to-end technology demonstration prototype for large scale UV laser systems for short wavelength inertial confinement fusion (ICF) research. The system employs optical angular multiplexing and serial amplification by electron-beam driven KrF laser amplifiers. The 1-5-ns pulse of the Aurora front end is split into ninety-six beams which are angularly and temporally multiplexed to produce a 480-ns pulse train for amplification by four KrF laser amplifiers. The largest amplifier, the large aperture module (LAM), has a 1-m square aperture and a gain length of 2 m. In the present system configuration half (forty-eight) of the amplified pulses are demultiplexed using different optical path lengths and delivered simultaneously to target. The system has not been optimized, and several near term improvements are expected to result in significant increases in both delivered energy and target irradiance. Removing the twelve calorimeters from the lens plate and allowing forty-eight beams to go to target will increase delivered energy by 33%. Relatively minor modifications to the front end should result in a 30% increase in system output energy. Replacement of damaged optics will increase transmission into the preamplifier by at least 25%. New optics and reduction of retro-pulses will allow the preamplifier stage gain to be increased by 50%

  9. Integration of the Aurora KrF ICF laser system at Los Alamos

    International Nuclear Information System (INIS)

    Rosocha, L.A.; Blair, L.S.

    1988-01-01

    The Aurora laser system, under construction at the Los Alamos National Laboratory for the past few years, is now being integrated into a working system for examining the applicability of high-power KrF lasers to inertial confinement fusion (ICF). The design principles of the system have been described in detail in earlier publications and conferences. Multikilojoule 248-nm 5-ns duration laser pulses, which have been derived from angular-multiplexed electron-beam-driven KrF amplifiers, are to be delivered to ICF targets when the system is fully integrated. The authors describe the progress of the Aurora system toward the goal of delivering energy (MkJ/48 pulses stacked into one 5-ns pulse/200-μm spot) to ICF targets. Integrated performance to date of the front end optical multiplexer/demultiplexer e-beam-driven amplifiers and alignment hardware are discussed in particular. They have concentrated on the demonstration of system integration at a modest (--100-J) level of energy on-target (without the final amplifier stage). They discuss the amplifier gain measurements, the extraction of energy from a chain of three e-beam-driven machines, and progress toward the delivery of on-target energy

  10. Jupiter's Aurora Observed With HST During Juno Orbits 3 to 7

    Science.gov (United States)

    Grodent, Denis; Bonfond, B.; Yao, Z.; Gérard, J.-C.; Radioti, A.; Dumont, M.; Palmaerts, B.; Adriani, A.; Badman, S. V.; Bunce, E. J.; Clarke, J. T.; Connerney, J. E. P.; Gladstone, G. R.; Greathouse, T.; Kimura, T.; Kurth, W. S.; Mauk, B. H.; McComas, D. J.; Nichols, J. D.; Orton, G. S.; Roth, L.; Saur, J.; Valek, P.

    2018-05-01

    A large set of observations of Jupiter's ultraviolet aurora was collected with the Hubble Space Telescope concurrently with the NASA-Juno mission, during an eight-month period, from 30 November 2016 to 18 July 2017. These Hubble observations cover Juno orbits 3 to 7 during which Juno in situ and remote sensing instruments, as well as other observatories, obtained a wealth of unprecedented information on Jupiter's magnetosphere and the connection with its auroral ionosphere. Jupiter's ultraviolet aurora is known to vary rapidly, with timescales ranging from seconds to one Jovian rotation. The main objective of the present study is to provide a simplified description of the global ultraviolet auroral morphology that can be used for comparison with other quantities, such as those obtained with Juno. This represents an entirely new approach from which logical connections between different morphologies may be inferred. For that purpose, we define three auroral subregions in which we evaluate the auroral emitted power as a function of time. In parallel, we define six auroral morphology families that allow us to quantify the variations of the spatial distribution of the auroral emission. These variations are associated with changes in the state of the Jovian magnetosphere, possibly influenced by Io and the Io plasma torus and by the conditions prevailing in the upstream interplanetary medium. This study shows that the auroral morphology evolved differently during the five 2 week periods bracketing the times of Juno perijove (PJ03 to PJ07), suggesting that during these periods, the Jovian magnetosphere adopted various states.

  11. Phenotypic Screening Approaches to Develop Aurora Kinase Inhibitors: Drug Discovery Perspectives.

    Science.gov (United States)

    Marugán, Carlos; Torres, Raquel; Lallena, María José

    2015-01-01

    Targeting mitotic regulators as a strategy to fight cancer implies the development of drugs against key proteins, such as Aurora-A and -B. Current drugs, which target mitosis through a general mechanism of action (stabilization/destabilization of microtubules), have several side effects (neutropenia, alopecia, and emesis). Pharmaceutical companies aim at avoiding these unwanted effects by generating improved and selective drugs that increase the quality of life of the patients. However, the development of these drugs is an ambitious task that involves testing thousands of compounds through biochemical and cell-based assays. In addition, molecules usually target complex biological processes, involving several proteins and different molecular pathways, further emphasizing the need for high-throughput screening techniques and multiplexing technologies in order to identify drugs with the desired phenotype. We will briefly describe two multiplexing technologies [high-content imaging (HCI) and flow cytometry] and two key processes for drug discovery research (assay development and validation) following our own published industry quality standards. We will further focus on HCI as a useful tool for phenotypic screening and will provide a concrete example of HCI assay to detect Aurora-A or -B selective inhibitors discriminating the off-target effects related to the inhibition of other cell cycle or non-cell cycle key regulators. Finally, we will describe other assays that can help to characterize the in vitro pharmacology of the inhibitors.

  12. Generation of ninety-six angularly multiplexed KrF beams at Aurora

    International Nuclear Information System (INIS)

    Rose, E.A.

    1987-01-01

    The Aurora KrF laser facility is designed to produce ninety-six laser beams at 248 nm with total energy of -- 10 kJ. The 5-ns duration beams are angularly multiplexed to allow sequential amplification in electron-beam-pumped amplifiers. These amplifiers operated over a half-microsecond period. Previous to this investigation, all individual components of the Aurora system have been operated independently. As a first step toward integration of the full system, the author operated the front end, beam slicer, small-aperture module (SAM), and angle encoder to generate ninety-six angularly multiplexed beams. These beams have been delivered to the first of the three large amplifiers, which will boost the pulse train energy from <1 J to 10 kJ. Measurements to date have concentrated on the total energy of the pulse train and pulse shapes of the individual beams at positions preceding and following SAM. Measured gain through SAM is -- 13 with 20 the target figure. Relative pulse heights are preserved through SAM with the exception of the first pulse of the 12

  13. Recent progress on the Los Alamos Aurora ICF [inertial confinement fusion] laser system

    International Nuclear Information System (INIS)

    Rosocha, L.A.; Blair, L.S.

    1987-01-01

    Aurora is the Los Alamos short-pulse, high-power, krypton-fluoride laser system. It serves as an end-to-end technology demonstration prototype for large-scale ultraviolet laser systems for short wavelength inertial confinement fusion (ICF) investigations. The system is designed to employ optical angular multiplexing and serial amplification by electron-beam-driven KrF laser amplifiers to deliver stacked, 248-nm, 5-ns duration multikilojoule laser pulses to ICF-relevant targets. This paper presents a summary of the Aurora system and a discussion of the progress achieved in the construction and integration of the laser system. We concentrate on the main features of the following major system components: front-end lasers, amplifier train, multiplexer, optical relay train, demultiplexer, and the associated optical alignment system. During the past year, two major construction and integration tasks have been accomplished. The first task is the demonstration of 96-beam multiplexing and amplified energy extraction, as evidenced by the integrated operation of the front end, the multiplexer (12-fold and 8-fold encoders), the optical relay train, and three electron-beam-driven amplifiers. The second task is the assembly and installation of the demultiplexer optical hardware, which consists of over 300 optical components ranging in size from several centimeters square to over a meter square. 13 refs., 13 figs

  14. Environmental impact assessment - baseline noise survey and noise impact assessment for Aurora Mine

    International Nuclear Information System (INIS)

    Yee, S.

    1996-01-01

    A noise impact assessment was conducted at Syncrude's proposed Aurora Mine site to comply with Alberta Energy and Utilities Board (AEUB) Noise Control Directive ID 94-4. Noise assessments were conducted near a major noise source, i.e. the hydraulic and electric shovels. Noise levels at 50 meters away from the source varied from 72.3 to 79.7 dBA. The worst case noise level was 75 dBA measured at 100 meters away from a hydraulic shovel. This assessment was used to calculate the predicted design sound level from a noise source at the nearest or most impacted occupied dwelling. Two cabins located near the access road and along Kearl Lake respectively, were identified as the most impacted and nearest dwellings to the mine site. The predicted sound level at one cabin was 43 dBA, and 55 dBA at the other. Fort McKay was also assessed because it is the nearest community to the mine site. The sound level at Fort McKay was predicted to be 34 dBA. These results indicate that the sound level from Aurora Mine is not in compliance with the AEUB Noise Control Directive. Attenuation measures are required to reduce the noise to acceptable level at Cabin A and B. Predicted sound level at Fort McKay is lower than the permitted sound level

  15. Phenotypic screening approaches to develop Aurora kinase inhibitors: Drug Discovery perspectives

    Directory of Open Access Journals (Sweden)

    Carlos eMarugán

    2016-01-01

    Full Text Available Targeting mitotic regulators as a strategy to fight cancer implies the development of drugs against key proteins such as Aurora A and B. Current drugs which target mitosis through a general mechanism of action (stabilization/destabilization of microtubules, have several side effects (neutropenia, alopecia, emesis. Pharmaceutical companies aim at avoiding these unwanted effects by generating improved and selective drugs that increase the quality of life of the patients. However, the development of these drugs is an ambitious task that involves testing thousands of compounds through biochemical and cell-based assays. In addition, molecules usually target complex biological processes, involving several proteins and different molecular pathways, further emphasizing the need for high-throughput screening techniques and multiplexing technologies in order to identify drugs with the desired phenotype.We will briefly describe two multiplexing technologies (high-content imaging, microarrays and flow cytometry and two key processes for drug discovery research (assay development and validation following our own published industry quality standards. We will further focus on high-content imaging as a useful tool for phenotypic screening and will provide a concrete example of high-content imaging assay to detect Aurora A or B selective inhibitors discriminating the off-target effects related to inhibition of other cell cycle or non-cell cycle key regulators. Finally, we will describe other assays that can help to characterize the in vitro pharmacology of the inhibitors.

  16. Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis

    Science.gov (United States)

    Kachaner, David; Pinson, Xavier; El Kadhi, Khaled Ben; Normandin, Karine; Talje, Lama; Lavoie, Hugo; Lépine, Guillaume; Carréno, Sébastien; Kwok, Benjamin H.; Hickson, Gilles R.

    2014-01-01

    Drosophila melanogaster Polo and its human orthologue Polo-like kinase 1 fulfill essential roles during cell division. Members of the Polo-like kinase (Plk) family contain an N-terminal kinase domain (KD) and a C-terminal Polo-Box domain (PBD), which mediates protein interactions. How Plks are regulated in cytokinesis is poorly understood. Here we show that phosphorylation of Polo by Aurora B is required for cytokinesis. This phosphorylation in the activation loop of the KD promotes the dissociation of Polo from the PBD-bound microtubule-associated protein Map205, which acts as an allosteric inhibitor of Polo kinase activity. This mechanism allows the release of active Polo from microtubules of the central spindle and its recruitment to the site of cytokinesis. Failure in Polo phosphorylation results in both early and late cytokinesis defects. Importantly, the antagonistic regulation of Polo by Aurora B and Map205 in cytokinesis reveals that interdomain allosteric mechanisms can play important roles in controlling the cellular functions of Plks. PMID:25332165

  17. Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.

    Science.gov (United States)

    Inaba, Hironori; Goto, Hidemasa; Kasahara, Kousuke; Kumamoto, Kanako; Yonemura, Shigenobu; Inoko, Akihito; Yamano, Shotaro; Wanibuchi, Hideki; He, Dongwei; Goshima, Naoki; Kiyono, Tohru; Hirotsune, Shinji; Inagaki, Masaki

    2016-02-15

    Primary cilia protrude from the surface of quiescent cells and disassemble at cell cycle reentry. We previously showed that ciliary reassembly is suppressed by trichoplein-mediated Aurora A activation pathway in growing cells. Here, we report that Ndel1, a well-known modulator of dynein activity, localizes at the subdistal appendage of the mother centriole, which nucleates a primary cilium. In the presence of serum, Ndel1 depletion reduces trichoplein at the mother centriole and induces unscheduled primary cilia formation, which is reverted by forced trichoplein expression or coknockdown of KCTD17 (an E3 ligase component protein for trichoplein). Serum starvation induced transient Ndel1 degradation, subsequent to the disappearance of trichoplein at the mother centriole. Forced expression of Ndel1 suppressed trichoplein degradation and axonemal microtubule extension during ciliogenesis, similar to trichoplein induction or KCTD17 knockdown. Most importantly, the proportion of ciliated and quiescent cells was increased in the kidney tubular epithelia of newborn Ndel1-hypomorphic mice. Thus, Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly. © 2016 Inaba et al.

  18. Detection of the 'continuous' H3(+) electrojet in the Jovian Aurora

    Science.gov (United States)

    Stallard, T. S.; Miller, S.; Achilleos, N.; Rego, D.; Prange, R.; Dougherty, M.; Joseph, R. D.

    1999-09-01

    Recently we have published the first detection of an auroral electrojet - a fast ion wind circulating around the auroral oval - on Jupiter (Rego et al., Nature, 399, 121-123). The detection was made during an unusual "auroral event", but raised the possibility that such electrojets might be detectable under "normal" auroral conditions. This work, currently in progress, is directed towards that aim. To accomplish this, high resolution infrared spectra and images of the Jovian aurora were taken on the nights of September 7-11(th) 1998, observing the nu_ {2} Q(1,0(-) ) line of H(+}_{3) at 3.953 mu m. The slit was aligned across the planet, perpendicular to the rotational axis, and the spectra were taken at 1 arcsec steps across the planet through the region of aurora. Each spectrum has been fitted row by row with a gaussian using height, width, background and central position as free parameters. This results in a measurement of how the relative central position varies across each spectra. Having processed the data, removing any systematic array effects, rotation, and instrumentally based spatial effects, we intend to show a measurable electrojet from the dopler shift it causes. This will be in the form of LOS maps of the auroral region at different CML taken over the 5 night observation period.

  19. Thermal Power Systems, Point-Focusing Distributed Receiver Technology Project. Annual technical report, Fiscal Year 1978. Volume II. Detailed report

    Energy Technology Data Exchange (ETDEWEB)

    1979-03-15

    Thermal or electrical power from the sun's radiated energy through Point-Focusing Distributed Receiver technology is the goal of this Project. The energy thus produced must be economically competitive with other sources. This Project supports the industrial development of technology and hardware for extracting energy from solar power to achieve the stated goal. Present studies are working to concentrate the solar energy through mirrors or lenses, to a working fluid or gas, and through a power converter change it to an energy source useful to man. Rankine-cycle and Brayton-cycle engines are currently being developed as the most promising energy converters for our near future needs. Accomplishments on point-focusing technology in FY 1978 are detailed.

  20. Modelling of fission gas release in rods from the International DEMO-RAMP-II Project at Studsvik

    International Nuclear Information System (INIS)

    Malen, K.

    1983-01-01

    The DEMO-RAMP-II rods had a burn-up of 25-30 MWd/kg U. They were ramped to powers in the range 40-50 kW/m with hold times between 10 s and 4.5 minutes. In spite of the short hold times the fission gas release at the higher powers was more than 1%. With these short hold times it is natural to assume that mixing of released gas with plenum gas is limited. Modelling has been performed using GAPCONSV (a modified GAPCON-THERMAL-2) both with and without mixing of released gas with plenum gas. In particular for the high power-short duration ramps only the ''no mixing'' modelling yields release fractions comparable to the experimental values. (author)

  1. 78 FR 23318 - Trust for Professional Managers and Aurora Investment Management L.L.C.; Notice of Application

    Science.gov (United States)

    2013-04-18

    ... subadvisory agreements (``Subadvisory Agreements'') with Chicago Fundamental Investment Partners, LLC, First... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30460; 812-14113] Trust for Professional Managers and Aurora Investment Management L.L.C.; Notice of Application April 12, 2013. AGENCY...

  2. The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage.

    Science.gov (United States)

    Leonard, Phoebe H; Grzenda, Adrienne; Mathison, Angela; Morbeck, Dean E; Fredrickson, Jolene R; de Assuncao, Thiago M; Christensen, Trace; Salisbury, Jeffrey; Calvo, Ezequiel; Iovanna, Juan; Coddington, Charles C; Urrutia, Raul; Lomberk, Gwen

    2015-05-29

    HP1γ, a well-known regulator of gene expression, has been recently identified to be a target of Aurora A, a mitotic kinase which is important for both gametogenesis and embryogenesis. The purpose of this study was to define whether the Aurora A-HP1γ pathway supports cell division of gametes and/or early embryos, using western blot, immunofluorescence, immunohistochemistry, electron microscopy, shRNA-based knockdown, site-directed mutagenesis, and Affymetrix-based genome-wide expression profiles. We find that the form of HP1γ phosphorylated by Aurora A, P-Ser83 HP1γ, is a passenger protein, which localizes to the spermatozoa centriole and axoneme. In addition, disruption in this pathway causes centrosomal abnormalities and aberrations in cell division. Expression profiling of male germ cell lines demonstrates that HP1γ phosphorylation is critical for the regulation of mitosis-associated gene expression networks. In female gametes, we observe that P-Ser83-HP1γ is not present in meiotic centrosomes of M2 oocytes, but after syngamy, it becomes detectable during cleavage divisions, coinciding with early embryonic genome activation. These results support the idea that phosphorylation of HP1γ by Aurora A plays a role in the regulation of gene expression and mitotic cell division in cells from the sperm lineage and in early embryos. Combined, this data is relevant to better understanding the function of HP1γ in reproductive biology.

  3. A Comparative Study of the Aneugenic and Polyploidy-inducing Effects of Fisetin and Two Model Aurora Kinase Inhibitors

    Science.gov (United States)

    Gollapudi, P.; Hasegawa, L.S.; Eastmond, D.A.

    2014-01-01

    Fisetin, a plant flavonol commonly found in fruits, nuts and vegetables, is frequently added to nutritional supplements due to its reported cardioprotective, anti-carcinogenic and antioxidant properties. Earlier reports from our laboratory and others have indicated that fisetin has both aneugenic and clastogenic properties in cultured cells. More recently, fisetin has also been reported to target Aurora B kinase, a Ser/Thr kinase involved in ensuring proper microtubule attachment at the spindle assembly checkpoint, and an enzyme that is overexpressed in several types of cancer. Here we have further characterized the chromosome damage caused by fisetin and compared it with that induced by two known Aurora kinase inhibitors, VX-680 and ZM-447439, in cultured TK6 cells using the micronucleus assay with CREST staining as well as a flow cytometry-based assay that measures multiple types of numerical chromosomal aberrations. The three compounds were highly effective in inducing aneuploidy and polyploidy as evidenced by increases in kinetochore-positive micronuclei, hyperdiploidy, and polyploidy. With fisetin, however, the latter two effects were most significantly observed only after cells were allowed to overcome a cell cycle delay, and occurred at higher concentrations than those induced by the other Aurora kinase inhibitors. Modest increases in kinetochore-negative micronuclei were also seen with the model Aurora kinase inhibitors. These results indicate that fisetin induces multiple types of chromosome abnormalities in human cells, and indicate a need for a thorough investigation of fisetin-augmented dietary supplements. PMID:24680981

  4. Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation

    NARCIS (Netherlands)

    Meppelink, Amanda; Kabeche, Lilian; Vromans, Martijn J M; Compton, Duane A; Lens, Susanne M A

    2015-01-01

    Correction of faulty kinetochore-microtubule attachments is essential for faithful chromosome segregation and dictated by the opposing activities of Aurora B kinase and PP1 and PP2A phosphatases. How kinase and phosphatase activities are appropriately balanced is less clear. Here, we show that a

  5. High expression of nuclear survivin and Aurora B predicts poor overall survival in patients with head and neck squamous cell cancer

    Energy Technology Data Exchange (ETDEWEB)

    Erpolat, O.P.; Akmansu, M. [Medical School of Gazi Univ., Besevler-Ankara (Turkey). Dept. of Radiation Oncology; Gocun, P.U.; Karakus, E.; Akyol, G. [Medical School of Gazi Univ., Besevler-Ankara (Turkey). Dept. of Pathology

    2012-03-15

    Survivin is one of the apoptosis inhibitor proteins. Together with Aurora B, it also plays a role in regulating several aspects of mitosis. High expression of these markers is correlated with malignant behavior of various cancers and resistance to therapy. Our aim was to evaluate the prognostic role of these markers in head and neck cancers. We evaluated the expression of Aurora B and survivin in tissue specimens of 58 patients with head and neck squamous cell carcinoma using immunohistochemistry. Patients who showed high expression of cytoplasmic and nuclear survivin and Aurora B had significantly shorter overall survival (p = 0.036, p < 0.000, p = 0.032, respectively). In multivariate analysis, high expression of nuclear survivin was the only independent negative prognostic factor (p = 0.024). Moreover, it was found that high co-expression of nuclear survivin and Aurora B had a negative effect on survival in univariate (p < 0.000) and multivariate (p < 0.000) analyses. The negative prognostic values of high expression of Aurora B and high co-expression of nuclear survivin and Aurora B on survival were shown. These findings suggest that co-expression of nuclear survivin and Aurora B can be useful diagnostic markers and therapeutic targets for head and neck squamous cell carcinoma. However, further studies with a larger number of patients in a more homogeneous disease group are needed to confirm the conclusion.

  6. Geometry of Moishezon and 1-convex spaces II: Projectivity of Moishezon spaces and its non-compact version

    International Nuclear Information System (INIS)

    Sitaramayya, M.

    1993-11-01

    After a brief review of the geometry of Moishezon spaces, their relation with l-convex spaces and a reasonable and up to date understanding of the obstructions for projectivity of Moishezon objects both in singular and non-singular case is given. The geometry of l-convex manifolds and with l-dimensional exceptional set is studied and some problems and conjectures are stated. The tools of cohomology vanishing theorems important for the subject are briefly sketched. Compactifications of C 3 and Stein spaces are finally outlined. given. 111 refs, 2 figs

  7. The Chemical Abundances of Stars in the Halo (CASH) Project. II. A Sample of 14 Extremely Metal-poor Stars

    Science.gov (United States)

    Hollek, Julie K.; Frebel, Anna; Roederer, Ian U.; Sneden, Christopher; Shetrone, Matthew; Beers, Timothy C.; Kang, Sung-ju; Thom, Christopher

    2011-11-01

    We present a comprehensive abundance analysis of 20 elements for 16 new low-metallicity stars from the Chemical Abundances of Stars in the Halo (CASH) project. The abundances have been derived from both Hobby-Eberly Telescope High Resolution Spectrograph snapshot spectra (R ~15, 000) and corresponding high-resolution (R ~35, 000) Magellan Inamori Kyocera Echelle spectra. The stars span a metallicity range from [Fe/H] from -2.9 to -3.9, including four new stars with [Fe/H] ratios with decreasing metallicity. Two of these objects can be classified as CEMP-no stars, adding to the growing number of these objects at [Fe/H]CASH and are used to calibrate a newly developed, automated stellar parameter and abundance determination pipeline. This code will be used for the entire ~500 star CASH snapshot sample. We find that the pipeline results are statistically identical for snapshot spectra when compared to a traditional, manual analysis from a high-resolution spectrum. Based on observations obtained with the Hobby-Eberly Telescope, which is a joint project of the University of Texas at Austin, the Pennsylvania State University, Stanford University, Ludwig-Maximilians-Universität München, and Georg-August-Universität Göttingen. Based on observations gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile.

  8. Fort Hood Solar Total Energy Project. Volume II. Preliminary design. Part 1. System criteria and design description. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1979-01-01

    This volume documents the preliminary design developed for the Solar Total Energy System to be installed at Fort Hood, Texas. Current system, subsystem, and component designs are described and additional studies which support selection among significant design alternatives are presented. Overall system requirements which form the system design basis are presented. These include program objectives; performance and output load requirements; industrial, statutory, and regulatory standards; and site interface requirements. Material in this section will continue to be issued separately in the Systems Requirements Document and maintained current through revision throughout future phases of the project. Overall system design and detailed subsystem design descriptions are provided. Consideration of operation and maintenance is reflected in discussion of each subsystem design as well as in an integrated overall discussion. Included are the solar collector subsystem; the thermal storage subsystem, the power conversion sybsystem (including electrical generation and distribution); the heating/cooling and domestic hot water subsystems; overall instrumentation and control; and the STES building and physical plant. The design of several subsystems has progressed beyond the preliminary stage; descriptions for such subsystems are therefore provided in more detail than others to provide complete documentation of the work performed. In some cases, preliminary design parameters require specific verificaton in the definitive design phase and are identified in the text. Subsystem descriptions will continue to be issued and revised separately to maintain accuracy during future phases of the project. (WHK)

  9. Alkaline Waterflooding Demonstration Project, Ranger Zone, Long Beach Unit, Wilmington Field, California. Fourth annual report, June 1979-May 1980. Volume 3. Appendices II-XVII

    Energy Technology Data Exchange (ETDEWEB)

    Carmichael, J.D.

    1981-03-01

    Volume 3 contains Appendices II through XVII: mixing instructions for sodium orthosilicate; oil displacement studies using THUMS C-331 crude oil and extracted reservoir core material from well B-110; clay mineral analysis of B-827-A cores; sieve analysis of 4 Fo sand samples from B-110-IA and 4 Fo sand samples from B-827-A; core record; delayed secondary caustic consumption tests; long-term alkaline consumption in reservoir sands; demulsification study for THUMS Long Beach Company, Island White; operating plans and instructions for DOE injection demonstration project, alkaline injection; caustic pilot-produced water test graphs; well test irregularities (6/1/79-5/31/80); alkaline flood pump changes (6/1/79-5/31/80); monthly DOE pilot chemical waterflood injection reports (preflush injection, alkaline-salt injection, and alkaline injection without salt); and caustic safety procedures-alkaline chemicals.

  10. Breaking the Ice: Strategies for Future European Research in the Polar Oceans - The AURORA BOREALIS Concept

    Science.gov (United States)

    Lembke-Jene, L.; Biebow, N.; Wolff-Boenisch, B.; Thiede, J.; European Research Icebreaker Consortium

    2011-12-01

    Research vessels dedicated to work in polar ice-covered waters have only rarely been built. Their history began with Fritjof Nansen's FRAM, which he used for his famous first crossing of the Arctic Ocean 1893-1896. She served as example for the first generation of polar research vessels, at their time being modern instruments planned with foresight. Ice breaker technology has developed substantially since then. However, it took almost 80 years until this technical advance also reached polar research, when the Russian AKADEMIK FEDEROV, the German POLARSTERN, the Swedish ODEN and the USCG Cutter HEALY were built. All of these house modern laboratories, are ice-breakers capable to move into the deep-Arctic during the summer time and represent the second generation of dedicated polar research vessels. Still, the increasing demand in polar marine research capacities by societies that call for action to better understand climate change, especially in the high latitudes is not matched by adequate facilities and resources. Today, no icebreaker platform exists that is permanently available to the international science community for year-round expeditions into the central Arctic Ocean or heavily ice-infested waters of the polar Southern Ocean around Antarctica. The AURORA BOREALIS concept plans for a heavy research icebreaker, which will enable polar scientists around the world to launch international research expeditions into the central Arctic Ocean and the Antarctic continental shelf seas autonomously during all seasons of the year. The European Research Icebreaker Consortium - AURORA BOREALIS (ERICON-AB) was established in 2008 to plan the scientific, governance, financial, and legal frameworks needed for the construction and operation of this first multi-nationally owned and operated research icebreaker and polar scientific drilling platform. By collaborating together and sharing common infrastructures it is envisioned that European nations make a major contribution to

  11. Fra radikalt samfunnsportrett til borgerlig idyll? En resepsjonsanalyse av Anne-Cath. Vestlys forfatterskap med hovedvekt på Aurora-bøkene

    OpenAIRE

    Vatnedalen, Mariell Bugge

    2015-01-01

    I min avhandling gjennomgår jeg utviklingen og tendensene i resepsjonen til Anne-Cath. Vestlys forfatterskap fra samtiden og fram til i dag, med Aurora-serien til å eksemplifisere. Jeg støtter meg til bøkene om Aurora i blokk Z (1966) og Aurora og pappa (1967), som tar for seg en familie som bryter med de tradisjonelle kjønnsrollemønstrene. Far er hjemmeværende student, glad i husarbeid og passer barn. Mor på den annen side er jurist i jobb og kjører bil - alt de...

  12. Safety evaluation for instrumentation and control system upgrading project of Malaysian TRIGA MARK II PUSPATI Research reactor

    International Nuclear Information System (INIS)

    Ridha Roslan; Nik Mohd Faiz Khairuddin

    2013-01-01

    Full-text: Malaysian TRIGA MARK II research reactor has been in safe operation since its first criticality in 1982. The reactor is licensed to be operated by Malaysian Nuclear Agency to perform training and research development related activities. Due to its extensive operation since last three decades, the option of modifications for safety and safety-related item and component become a necessary to replace the outdated equipment to a stat-of-art, reliable technologies. This paper will present the current regulatory activities performed by Atomic Energy Licensing Board (AELB) to ensure the upgrading of analogue to digital instrumentation and control system is implemented in safe manner. The review activity includes documentation review, manufacturer quality audit and on-site inspection for commissioning. The review performed by AELB is based on The International Atomic Energy Agency (IAEA) Safety Requirements NS-R-4, entitled Safety of Research Reactors. During this endeavour, AELB seeks technical cooperation from Korea Institute of Nuclear Safety (KINS), the nuclear experts organization of the country of origin of the instrumentation and control technology. The regulatory activity is still on-going and is expected to be completed by issuance of Authorization for Restart on December 2013. (author)

  13. Final programmatic environmental impact statement for the uranium mill tailings remedial action ground water project. Volume II

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-10-01

    Volume II of the programmatic environmental impact statement (PElS) is a comment and response document; it is the collection of the comments received on the draft PElS. The U.S. Department of Energy's (DOE) response to each comment is provided after each comment. If the comment resulted in a change to the PElS, the affected section number of the PElS is provided in the response. Comments 1 through 259 were received at public hearings. The name of the hearing at which the comment was received is listed after each comment. Comments were recorded on flip charts and by notetakers. DOE representatives were present to hear the comments and respond to them. The DOE's written response is provided after each comment. Comments 260 through 576 were received in writing at the hearings, and from various federal, tribal, and state agencies and from individuals during the public comment period. Copies of the written comments follow the comments and responses.

  14. Final programmatic environmental impact statement for the uranium mill tailings remedial action ground water project. Volume II

    International Nuclear Information System (INIS)

    1996-01-01

    Volume II of the programmatic environmental impact statement (PElS) is a comment and response document; it is the collection of the comments received on the draft PElS. The U.S. Department of Energy's (DOE) response to each comment is provided after each comment. If the comment resulted in a change to the PElS, the affected section number of the PElS is provided in the response. Comments 1 through 259 were received at public hearings. The name of the hearing at which the comment was received is listed after each comment. Comments were recorded on flip charts and by notetakers. DOE representatives were present to hear the comments and respond to them. The DOE's written response is provided after each comment. Comments 260 through 576 were received in writing at the hearings, and from various federal, tribal, and state agencies and from individuals during the public comment period. Copies of the written comments follow the comments and responses

  15. Assessment of the feasibility of studying the potential health effects of the West Valley Solidification Project. Phase II

    International Nuclear Information System (INIS)

    Matanoski, G.M.

    The activities at West Valley involve potential exposure to ionizing radiation. The health effects from radiation are well known and the projected levels of exposure in this situation are so low as to pose no known health hazard in the community. In such a situation it is not reasonable to propose an expensive, comprehensive and physically invasive screening program for the public unless one could justify the benefits. This report describes a feasible population-based surveillance or disease monitoring system which could be implemented in the West Valley area in order to assess the relevance of any changes in incidence of disease which might be attributable to radiation. The proposed plan is both practical and inexpensive. It would anticipate any potential changes in the health status of the population and provide a means to objectively interpret such changes before major concerns develop

  16. LIFAC Demonstration at Richmond Power and Light Whitewater Valley Unit No. 2 Volume II: Project Performance and Economics

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    1998-04-01

    The C1ean Coal Technology (CCT) Program has been recognized in the National Energy Strategy as a major initiative whereby coal will be able to reach its full potential as a source of energy for the nation and the international marketplace. Attainment of this goal depends upon the development of highly efficient, environmentally sound, competitive coal utilization technologies responsive to diverse energy markets and varied consumer needs. The CCT Program is an effort jointly funded by government and industry whereby the most promising of the advanced coal-based technologies are being moved into the marketplace through demonstration. The CCT Program is being implemented through a total of five competitive solicitations. LIFAC North America, a joint venture partnership of ICF Kaiser Engineers, Inc., and Tampella Power Corporation, is currently demonstrating the LIFAC flue gas desulfurization technology developed by Tampella Power. This technology provides sulfur dioxide emission control for power plants, especially existing facilities with tight space limitations. Sulfur dioxide emissions are expected to be reduced by up to 85% by using limestone as a sorbent. The LIFAC technology is being demonstrated at Whitewater Valley Unit No. 2, a 60-MW coal-fired power plant owned and operated by Richmond Power and Light (RP&L) and located in Richmond, Indiana. The Whitewater plant consumes high-sulfur coals, with sulfur contents ranging from 2.0-2.9 $ZO. The project, co-funded by LIFAC North America and DOE, is being conducted with the participation of Richmond Power and Light, the State of Indiana, the Electric Power Research Institute (EPRI), and the Black Beauty Coal Company. The project has a total cost of $21.4 million and a duration of 48 months from the preliminary design phase through the testing program.

  17. GPS Signal Corruption by the Discrete Aurora: Precise Measurements From the Mahali Experiment

    Science.gov (United States)

    Semeter, Joshua; Mrak, Sebastijan; Hirsch, Michael; Swoboda, John; Akbari, Hassan; Starr, Gregory; Hampton, Don; Erickson, Philip; Lind, Frank; Coster, Anthea; Pankratius, Victor

    2017-10-01

    Measurements from a dense network of GPS receivers have been used to clarify the relationship between substorm auroras and GPS signal corruption as manifested by loss of lock on the received signal. A network of nine receivers was deployed along roadways near the Poker Flat Research Range in central Alaska, with receiver spacing between 15 and 30 km. Instances of large-amplitude phase fluctuations and signal loss of lock were registered in space and time with auroral forms associated with a sequence of westward traveling surges associated with a substorm onset over central Canada. The following conclusions were obtained: (1) The signal corruption originated in the ionospheric E region, between 100 and 150 km altitude, and (2) the GPS links suffering loss of lock were confined to a narrow band (<20 km wide) along the trailing edge of the moving auroral forms. The results are discussed in the context of mechanisms typically cited to account for GPS phase scintillation by auroral processes.

  18. Our life is protected by the Earth's atmosphere and magnetic field: what aurora research tells us.

    Science.gov (United States)

    Kamide, Y

    2001-01-01

    Our sun is an average middle-aged star. Without the sun, there would be no atmosphere, no water, and no life on the Earth. The sun is constantly changing, providing the Earth with energy through a complicated chain of processes that occur in space surrounding the Earth. This paper demonstrates that life on Earth is protected by two barriers, i.e., the atmosphere and the magnetic field, against otherwise menacing events in space. Because of these shielding effects, we, peacefully sitting on the Earth's surface, are not aware of a number of critical and potentially dangerous episodes that are taking place only 100 km above the Earth's surface. The aurora, which dances in the polar sky also because of the two barriers, is sending us a crucial hint about what is happening in space.

  19. Baseline vegetation inventory and productivity assessment for the Syncrude Aurora Mine EIA local study area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    This report presented an inventory and assessment of vegetation communities and forest covers within the proposed Aurora Mine local study area. A field inventory was conducted in the summer of 1995 to ground-truth air photo interpretations and to collect data. The inventory includes a classification of vegetation, forest covers and wetlands. It also includes the documentation of uncommon plants and the vegetation productivity estimates of tree, shrub and herbaceous plants. The study area is located east of the Athabasca River about 35 km northeast of Mildred Lake Oil Sands Plant. The area includes portions of Oil Sands Leases 10, 12, 13, 31, and 34 which includes much of the Muskeg River drainage and all of Kearl Lake. 24 refs., 7 tabs., 3 figs.

  20. Coordinated observations of electron energy spectra and electrostatic cyclotron waves during diffuse auroras

    International Nuclear Information System (INIS)

    Fontaine, D.; Perraut, S.; Cornilleau-Wehrlin, N.; Aparicio, B.; Bosqued, J.M.; Rodgers, D.

    1986-01-01

    An auroral precipitation event lasting several hours in the dusk sector on June 2, 1982 is studied in conjunction with three instruments: the EISCAT European Incoherent Scatter radar based in Scandinavia, the GEOS-2 European geostationary spacecraft, and the ARCAD-3 French-Soviet polar spacecraft. Electron energy spectra between about 1 and 10 keV, computed from EISCAT measurements, were in agreement, during a diffuse aurora period, with direct observations onboard ARCAD-3, and also with the plasma sheet component (3-10 keV) measured onboard GEOS-2 and available at large pitch-angles. This last comparison suggested the quasi-isotropy of equatorial electron fluxes. The electrostatic electron cyclotron harmonic waves, also observed onboard GEOS-2, were not found to be intense enough to cause by themselves the strong pitch-angle diffusion of electrons of a few keV

  1. Performance studies of a time projection chamber at the ILC and search for lepton flavour violation at HERA II

    Energy Technology Data Exchange (ETDEWEB)

    Janssen, M.E.

    2008-05-15

    It is expected, that new physics beyond the Standard Model can be discovered in the energy range of 1TeV. One of the next projects in high energy physics will be a linear collider. A proposal for such a machine is the International Linear Collider (ILC), where electrons and positrons are brought to collision with a centre of mass energy up to 500 GeV with the possibility to upgrade it to 1 TeV. The precision measurement of this new physics sets high requirements on the performance of the detector at the ILC. As the main tracking device for a detector at the ILC, a Time Projection Chamber (TPC) has been proposed. To reach these requirements a new amplification techniques based on Micro Pattern Gas Detectors (MPGD) is under investigation. In this thesis, data are analysed, that were taken using the prototype MediTPC, whose amplification system is based on Gas Electron Multipliers (GEM). Different magnetic fields of up to 4 T, two gas mixtures and differed arrangement of the pads have also been investigated. The main part of this thesis deals with the study of the performance of two different approaches to determine track parameters. A new method based on a likelihood fit of the expected charge to the measured one is compared to a traditional approach using reconstructed space points and a {chi}{sup 2} minimisation technique. Different aspects such as the performance in the presence of non working channels and the angular dependency are investigated. Finally the determined spatial resolution (in the r{phi}-plane) is presented. At zero drift length a resolution of the order of 100 {mu}m can be achieved. In the second part of this thesis the results of a search for lepton flavour violation mediated by leptoquarks is presented. Data of electron-proton collisions with a centre-of-mass energy of 320 GeV taken with the H1 experiment are investigated. The analysis concentrates of the e{sup -}p data of the HERAII phase, which were taken in the years 2004-2006. They correspond

  2. Pitch angle scattering and particle precipitation in a pulsating aurora - an experimental study

    International Nuclear Information System (INIS)

    Sandahl, I.

    1984-10-01

    A pulsating aurora occurring during the recovery phase of a substorm on January 27, 1979 was monitored by a large set of instruments. The Swedish sounding rocket S23-L2 was launched at magnetic midnight over pulsating patches, some of which exhibited 3+-1 Hz modulation. The ground based instrumentation included auroral TV cameras, all sky cameras, photometers and magnetometers. The geostationary satellite GEOS-2 was located in the equatorial plane, approximately conjugate to the rocket. The central experiment of this study is the particle experiment on the rocket. Several aspects of pulsating auroras have been investigated. The auroral luminosity variations were very well correlated to variations in the flux of precipitating hot electrons. The 1-20 second pulsations were caused by increased fluxes of 4-40 keV electrons. The 3+-1 Hz modulation was detected in 7-200 keV electrons, but the biggest energy flux modulation occurred for electrons of about 60 keV. Model calculations involving the electron distributions measured by the sounding rocket and GEOS-2, consistently show that the electrons may have been scattered into the loss cone through the Doppler shifted gyroresonance with whistler mode waves. The scattering was not a pure pitch angle scattering as in the classical Coroniti and Kennel theory, but involved also a systematic energy loss from the particles. The waves were probably hiss with some chorus elements. The equatorial plane plasma density was estimated in two independent ways to be about 2x10 6 m- 3 . The 3+-1 Hz modulation was measured both by the particle experiment on the rocket and by the wave experiment on GEOS-2. Properties of the modulated fluxes are described and a qualitative model for the cause of the modulation is proposed. (author)

  3. Dayside aurorae and polar arcs under south-east IMF orientation

    Directory of Open Access Journals (Sweden)

    P. E. Sandholt

    2006-12-01

    Full Text Available We document a characteristic spatial and temporal structure of the aurora in the postnoon sector present during a 10-h-long interval of very steady southeast IMF orientation (clock angle=135° ending in a sharp south-to-north transition. Focus is placed on the detailed morphology of auroral forms/activities corresponding to merging and lobe convection cells obtained from SuperDARN convection data and Greenland magnetograms. The ground optical instruments at Ny Ålesund, Svalbard (76° MLAT recorded different auroral forms/activities as the station moved to higher magnetic local times (MLTs in the 13:00–17:00 MLT sector. Whereas the 13:00–15:00 MLT sector is characterized by classical poleward moving auroral forms (PMAFs associated with merging cell transients, the aurora in the 15:00–17:00 MLT sector shows instead a characteristic latitudinal bifurcation consisting of standard oval forms and polar arcs, and a corresponding composite pattern of merging and lobe convection cells. The merging and lobe cells respond to the southward and northward IMF transitions by activation/fading and fading/activation, respectively. A sequence of brightening events is characterized by successive activations progressing in latitude from the merging cell regime to the lobe cell regime. Emphasis is placed on the association between polar arc brightenings and the activation of the channel of enhanced sunward flow in the lobe cell. The observations are discussed in relation to recent work on solar wind-magnetosphere-ionosphere interconnection topology.

  4. New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.

    Science.gov (United States)

    Abd El-All, Amira S; Magd-El-Din, Asmaa A; Ragab, Fatma A F; ElHefnawi, Mahmoud; Abdalla, Mohamed M; Galal, Shadia A; El-Rashedy, Ahmed A

    2015-07-01

    A newly synthesized series of anticancer compounds comprising thiazolo[3,2-a]pyrimidine derivatives 6a-q bearing a benzimidazole moiety was produced via a one-pot reaction of N-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-2-cyanoacetamide 5 with 2-aminothiazole and an appropriate aromatic aldehyde. Compound 7 was obtained via the reaction of 4-(1H-benzo[d]imidazol-2yl)benzenamide 1 with carbon disulphide and methyl iodide in the presence of concentrated aqueous solution of NaOH, then treated with o-phenylenediamine to give N-(4-1H-benzo[d]imidazol-2-yl)phenyl)-1H-benzo[d]imidazol-2-amine 8. The structures of the newly synthesized compounds were confirmed by analytical and spectroscopic measurements (IR, MS, and (1) H NMR). The synthesized products were screened and studied for their in vitro antitumor activity against three human cancer cell lines (namely colorectal cancer cell line HCT116, human liver cancer cell line HepG2, and human ovarian cancer cell line A2780) and their Aurora A kinase and KSP inhibitory activities. All newly synthesized compounds revealed marked results comparable with the standard drug CK0106023. The compounds 6e and 6k of the thiazolopyrimidine derivatives were the most active compounds when tested against the three cell lines in comparison with the standard drug CK0106023, and showed potent dual KSP and Aurora A kinase inhibition. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Aurora-A Expression Is Independently Associated with Chromosomal Instability in Colorectal Cancer

    Directory of Open Access Journals (Sweden)

    Yoshifumi Baba

    2009-05-01

    Full Text Available AURKA (the official symbol for Aurora-A, STK15, or BTAK regulates the function of centrosomes, spindles, and kinetochores for proper mitotic progression. AURKA overexpression is observed in various cancers including colon cancer, and a link between AURKA and chromosomal instability (CIN has been proposed. However, no study has comprehensively examined AURKA expression in relation to CIN or prognosis using a large number of tumors. Using 517 colorectal cancers in two prospective cohort studies, we detected AURKA overexpression (by immunohistochemistry in 98 tumors (19%. We assessed other molecular events including loss of heterozygosity (LOH in 2p, 5q, 17q, and 18q, the CpG island methylation phenotype (CIMP, and microsatellite instability (MSI. Prognostic significance of AURKA was evaluated by Cox regression and Kaplan-Meier method. In both univariate and multivariate logistic regressions, AURKA overexpression was significantly associated with CIN (defined as the presence of LOH in any of the chromosomal segments; multivariate odds ratio, 2.97; 95% confidence interval, 1.40–6.29; P = .0045. In multivariate analysis, AURKA was associated with cyclin D1 expression (P = .010 and inversely with PIK3CA mutation (P=.014, fatty acid synthase expression (P=.028, and family history of colorectal cancer (P = .050, but not with sex, age, body mass index, tumor location, stage, CIMP, MSI, KRAS, BRAF, BMI, LINE-1 hypomethylation, p53, p21, β-catenin, or cyclooxygenase 2. AURKA was not significantly associated with clinical outcome or survival. In conclusion, AURKA overexpression is independently associated with CIN in colorectal cancer, supporting a potential role of Aurora kinase-A in colorectal carcinogenesis through genomic instability (rather than epigenomic instability.

  6. The hELENa project - II. Abundance distribution trends of early-type galaxies: from dwarfs to giants

    Science.gov (United States)

    Sybilska, A.; Kuntschner, H.; van de Ven, G.; Vazdekis, A.; Falcón-Barroso, J.; Peletier, R. F.; Lisker, T.

    2018-06-01

    In this second paper of The role of Environment in shaping Low-mass Early-type Nearby galaxies (hELENa) series we study [Mg/Fe] abundance distribution trends of early-type galaxies (ETGs) observed with the Spectrographic Areal Unit for Research on Optical Nebulae integral field unit, spanning a wide range in mass and local environment densities: 20 low-mass early types (dEs) of Sybilska et al. and 258 massive early types (ETGs) of the ATLAS3D project, all homogeneously reduced and analysed. We show that the [Mg/Fe] ratios scale with velocity dispersion (σ) at fixed [Fe/H] and that they evolve with [Fe/H] along similar paths for all early types, grouped in bins of increasing local and global σ, as well as the second velocity moment Vrms, indicating a common inside-out formation pattern. We then place our dEs on the [Mg/Fe] versus [Fe/H] diagram of Local Group galaxies and show that dEs occupy the same region and show a similar trend line slope in the diagram as the high-metallicity stars of the Milky Way and the Large Magellanic Cloud. This finding extends the similar trend found for dwarf spheroidal versus dwarf irregular galaxies and supports the notion that dEs have evolved from late-type galaxies that have lost their gas at a point of their evolution, which likely coincided with them entering denser environments.

  7. The Chemical Abundances of Stars in the Halo (CASH) Project. II. New Extremely Metal-poor Stars

    Science.gov (United States)

    Krugler, Julie A.; Frebel, A.; Roederer, I. U.; Sneden, C.; Shetrone, M.; Beers, T.; Christlieb, N.

    2011-01-01

    We present new abundance results from the Chemical Abundances of Stars in the Halo (CASH) project. The 500 CASH spectra were observed using the Hobby-Eberly Telescope in "snapshot" mode and are analyzed using an automated stellar parameter and abundance pipeline called CASHCODE. For the 20 most metal-poor stars of the CASH sample we have obtained high resolution spectra using the Magellan Telescope in order to test the uncertainties and systematic errors associated with the snapshot quality (i.e., R 15,000 and S/N 65) HET spectra and to calibrate the newly developed CASHCODE by making a detailed comparison between the stellar parameters and abundances determined from the high resolution and snapshot spectra. We find that the CASHCODE stellar parameters (effective temperature, surface gravity, metallicity, and microturbulence) agree well with the results of the manual analysis of the high resolution spectra. We present the abundances of three newly discovered stars with [Fe/H] ratios with alpha-enhancement and Fe-peak depletion and a range of n-capture elements. The full CASH sample will be used to derive statistically robust abundance trends and frequencies (e.g. carbon and n-capture), as well as placing constraints on nucleosynthetic processes that occurred in the early universe.

  8. THE CHEMICAL ABUNDANCES OF STARS IN THE HALO (CASH) PROJECT. II. A SAMPLE OF 14 EXTREMELY METAL-POOR STARS ,

    International Nuclear Information System (INIS)

    Hollek, Julie K.; Sneden, Christopher; Shetrone, Matthew; Frebel, Anna; Roederer, Ian U.; Beers, Timothy C.; Kang, Sung-ju; Thom, Christopher

    2011-01-01

    We present a comprehensive abundance analysis of 20 elements for 16 new low-metallicity stars from the Chemical Abundances of Stars in the Halo (CASH) project. The abundances have been derived from both Hobby-Eberly Telescope High Resolution Spectrograph snapshot spectra (R ∼15, 000) and corresponding high-resolution (R ∼35, 000) Magellan Inamori Kyocera Echelle spectra. The stars span a metallicity range from [Fe/H] from –2.9 to –3.9, including four new stars with [Fe/H] < –3.7. We find four stars to be carbon-enhanced metal-poor (CEMP) stars, confirming the trend of increasing [C/Fe] abundance ratios with decreasing metallicity. Two of these objects can be classified as CEMP-no stars, adding to the growing number of these objects at [Fe/H]< – 3. We also find four neutron-capture-enhanced stars in the sample, one of which has [Eu/Fe] of 0.8 with clear r-process signatures. These pilot sample stars are the most metal-poor ([Fe/H] ∼< –3.0) of the brightest stars included in CASH and are used to calibrate a newly developed, automated stellar parameter and abundance determination pipeline. This code will be used for the entire ∼500 star CASH snapshot sample. We find that the pipeline results are statistically identical for snapshot spectra when compared to a traditional, manual analysis from a high-resolution spectrum.

  9. O desenvolvimento participativo da área de medicina tradicional indígena, Projeto Vigisus II/Funasa The participant development in traditional indigenous medicine area, Project Vigisus II/Funasa

    Directory of Open Access Journals (Sweden)

    Luciane Ouriques Ferreira

    2012-05-01

    Full Text Available O artigo trata sobre o desenvolvimento participativo das ações da Área de Medicina Tradicional Indígena (AMT do Projeto Vigisus II/FUNASA. A Área tem como objetivo a construção de estratégias para a articulação entre os sistemas médicos indígenas e o sistema oficial de saúde, conforme preconizado pela Política Nacional de Atenção a Saúde dos Povos Indígenas. As principais atividades executadas foram os projetos participativos de pesquisa-ação que podem ser classificados em três eixos transversais: sistemas tradicionais de parto indígenas; plantas medicinais; xamanismo e intermedicalidade. Os resultados qualitativos alcançados pelo eixo sistemas de parto indígenas são aqui apresentados de modo a demonstrar o quanto a articulação dos serviços de saúde com as medicinas tradicionais indígenas é condição fundamental para a efetivação do princípio da integralidade em um modelo diferenciado de atenção à saúde indígena.The article presents the participative planning of health care actions in the Indigenous Traditional Medicine Department, of Project Vigisus II/Funasa (National Foundation for Health. This department's function is to build strategies for the articulation between the indigenous medicine systems and the official health care system, was is established at the National Health Care Policy for Indigenous People. The main activities developed were participant projects of research-action organized along three transverse axes: indigenous childbirth's traditional systems; medicine plants; shamanism and intermedicine. Qualitative results reached at the indigenous systems of childbirth axis are presented here, in order to show how the articulation with traditional indigenous medicine is a core condition to fulfill the principle of integrality in a differentiated model of indigenous health care.

  10. Medical Isotopes Production Project: Molybdenum-99 and related isotopes - environmental impact statement. Volume II, comment response document

    International Nuclear Information System (INIS)

    1996-04-01

    This Environmental Impact Statement (EIS) provides environmental and technical information concerning the U.S. Department of Energy's (DOE) proposal to establish a domestic source to produce molybdenum-99 (Mo-99) and related isotopes (iodine-131, xenon-133, and iodine-125). Mo-99, a radioactive isotope of the element molybdenum, decays to form metastable technetium-99 (Tc-99m), a radioactive isotope used thousands of times daily in medical diagnostic procedures in the U.S. Currently, all Mo-99 used in the U.S. is obtained from a single Canadian source. DOE is pursuing the Medical Isotopes Production Project in order to ensure that a reliable supply of Mo-99 is available to the U.S. medical community as soon as practicable. Under DOE's preferred alternative, the Chemistry and Metallurgy Research Facility at the Los Alamos National Laboratory (LANL) and the Annular Core Research Reactor and Hot Cell Facility at Sandia National Laboratories/New Mexico (SNL/NM) would be used for production of the medical isotopes. In addition, three other reasonable alternatives and a No Action alternative are analyzed in detail, The sites for these three reasonable alternatives are LANL, Oak Ridge National Laboratory (ORNL), and Idaho National Engineering Laboratory (INEL). The analyses in this EIS indicate no significant difference in the potential environmental impacts among the alternatives. Each of the alternatives would use essentially the same technology for the production of the medical isotopes. Minor differences in environmental impacts among alternatives relate to the extent of activity necessary to modify and restart (as necessary) existing reactors and hot cell facilities at each of the sites, the quantities of low-level radioactive waste generated, how such waste would be managed, and the length of time needed for initial and full production capacity. This document contains comments recieved from meetings held regarding the site selection for isotope production

  11. Transiting Exoplanet Monitoring Project (TEMP). II. Refined System Parameters and Transit Timing Analysis of HAT-P-33b

    Science.gov (United States)

    Wang, Yong-Hao; Wang, Songhu; Liu, Hui-Gen; Hinse, Tobias C.; Laughlin, Gregory; Wu, Dong-Hong; Zhang, Xiaojia; Zhou, Xu; Wu, Zhenyu; Zhou, Ji-Lin; Wittenmyer, R. A.; Eastman, Jason; Zhang, Hui; Hori, Yasunori; Narita, Norio; Chen, Yuanyuan; Ma, Jun; Peng, Xiyan; Zhang, Tian-Meng; Zou, Hu; Nie, Jun-Dan; Zhou, Zhi-Min

    2017-08-01

    We present 10 R-band photometric observations of eight different transits of the hot Jupiter HAT-P-33b, which has been targeted by our Transiting Exoplanet Monitoring Project. The data were obtained by two telescopes at the Xinglong Station of National Astronomical Observatories of China (NAOC) from 2013 December through 2016 January, and exhibit photometric scatter of 1.6{--}3.0 {mmag}. After jointly analyzing the previously published photometric data, radial-velocity (RV) measurements, and our new light curves, we revisit the system parameters and orbital ephemeris for the HAT-P-33b system. Our results are consistent with the published values except for the planet to star radius ratio ({R}{{P}}/{R}* ), the ingress/egress duration (τ) and the total duration (T 14), which together indicate a slightly shallower and shorter transit shape. Our results are based on more complete light curves, whereas the previously published work had only one complete transit light curve. No significant anomalies in Transit Timing Variations (TTVs) are found, and we place upper mass limits on potential perturbers, largely supplanting the loose constraints provided by the extant RV data. The TTV limits are stronger near mean-motion resonances, especially for the low-order commensurabilities. We can exclude the existence of a perturber with mass larger than 0.6, 0.3, 0.5, 0.5, and 0.3 {M}\\oplus near the 1:3, 1:2, 2:3, 3:2, and 2:1 resonances, respectively.

  12. APIO-EE-9 is a novel Aurora A and B antagonist that suppresses esophageal cancer growth in a PDX mouse model.

    Science.gov (United States)

    Jin, Guoguo; Yao, Ke; Guo, Zhiping; Zhao, Zhenjiang; Liu, Kangdong; Liu, Fangfang; Chen, Hanyong; Gorja, Dhilli Rao; Reddy, Kanamata; Bode, Ann M; Dong, Ziming; Dong, Zigang

    2017-08-08

    Esophageal cancer (EC) is one of the most aggressive malignancies of the upper aerodigestive tract. Over the past three decades, with advances in surgical techniques and treatment, the prognosis of esophageal cancer has only slowly improved. Thus identifying novel molecular targets and developing therapeutic agents are critical. Aurora kinases play a crucial role in mitosis and selective inhibitors might provide an effective therapeutic treatment for cancer. However, the role of Aurora kinases in EC is still inadequately studied. Here, we identified a novel compound, referred to as APIO-EE-9, which inhibits growth and colony formation and induces apoptosis of esophageal cancer cells. Using computer modeling, we found that APIO-EE-9 interacted with both Aurora A and B in the ATP-binding pocket. APIO-EE-9 inhibited both Aurora A and B kinase activities in a dose-dependent manner. Treatment with APIO-EE-9 substantially reduced the downstream Aurora kinase phosphorylation of histone H3 (Ser10), resulting in formation of multiple nuclei and centrosomes. Additionally, esophageal cancer cells expressing shAurora A or shAurora B kinase exhibited a dramatic reduction in proliferation and colony formation. Injection of these cells as xenografts in mice reduced tumor formation compared to wildtype cells. Importantly, APIO-EE-9 significantly decreased the size of esophageal patient-derived xenograft (PDX) tumors implanted in SCID mice. These results demonstrated that APIO-EE-9 is a specific Aurora kinase inhibitor that could be developed as a therapeutic agent against esophageal cancer.

  13. Joint project final report, Task II: Sulfur chemistry, Task III: Nitrogen Chemistry[Straw fired power plants

    Energy Technology Data Exchange (ETDEWEB)

    Glarborg, P.; Lans, R. van der; Weigang, L.; Arendt Jensen, P.; Degn Jensen, A.; Dam-Johansen, K.

    2001-09-01

    It is the aim of the project to promote the use of biomass in the production of power and heat in Denmark as well as enhancing the technology base of the Danish industry within this area. The project involves, the following task areas: 1) Deposit Build-up; 2) Sulfur Chemistry; 3) Nitrogen Chemistry; and 4) Furnace Modeling. The present report covers the activities in task 2 and 3, which are carried out at Department of Chemical Engineering, DTU. Task 2: Sulfur chemistry: The lab-scale results show that the amount of sulfur released into the gas-phase increases at high temperatures. Other process parameters such as oxygen concentration have less impact. Little sulfur is apparently released during char oxidation. The experiments show that about 40% of the sulfur is released during pyrolysis at 400 {sup d}eg{sup .}C. At combustion conditions it was found that about 50% of the sulfur is released at 500{sup d}eg.{sup C}; above this temperature an almost linear correlation is found beteen sulfur release and combustion temperature up to 80-85% release at 950{sup d}eg.{sup C}. The experiments are in agreement with results from full scale straw fired grate boilers, indicating that only a small amount of fuel-sulfur is fixed in the bottom ash under typical operating conditions. The results are important in order to understand the varying emission levels observed in full-scala systems and provide guidelines for low SO{sub 2} operation. Task 3: Nitrogen chemistry: In the nitgrogen chemistry submodel volatile-N is released as NH{sub 3} and N{sub 2}. The ammonia can react further to N{sub 2} or NO. Char nitrogen is oxidized to NO, and the char bed acts as a catalyst for the reduction of NO to N{sub 2}. Predictions with the bed-model including the NO submodel indicate that when all volatile nitrogen is converted to NH{sub 3}, the concentrations og NH{sub 3} are significantly overpredicted. This means that either the NH{sub 3} reaction rates are underpredicted or that a smaller

  14. Rosmarinic acid plays a protective role in the embryogenesis of zebrafish exposed to food colours through its influence on aurora kinase A level.

    Science.gov (United States)

    Swarnalatha, Y; Jerrine Joseph, I S; Jayakrishna, Tippabathani

    2017-05-01

    To evaluate the protective nature of the rosmarinic acid from Sphaeranthus amaranthoides during zebra fish embryogenesis. Rosmarinic acid was isolated from the S. amaranthoides. An accurate, sensitive and simple LC-MS analysis was performed to determine the rosmarinic acid from S. amaranthoides. In the present study, zebrafish embryos were exposed to crimson red and sunset yellow at a concentration of 0.1 and 0.5mg/l and the effect of these food colours on the levels of aurora kinase A was studied individually. Aurora kinase A levels are crucial for embryogenesis in zebrafish which is used as model in this study. The decrease of aurora kinase A levels in food colour treated embryos influences the embryogenesis, resulting in short and bent trunk leading to cell death and growth retardation. Elevated levels of aurora kinase A in rosmarinic acid treated groups can be attributed to the restoration of normal growth in zebra fish embryos with well developed brain and eyes. Further insilico docking studies were carried out and target was identified as rosmarinic acid. From the docking studies the docking poses and binding energy confirms that aurora kinase A is the target for rosmarinic acid. Rosmarinic acid was found to play a protective role in the embryogenesis of zebra fish exposed to food colours (crimson red and sunset yellow) through its influence on aurora kinase A levels. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  15. Strategies for the long-term climate policy. The results of the Cool project. Final report of the second phase of the Dutch National Research Programme on Global Air Pollution and Climate Change (NRP II) 1995-2001. Part 2

    NARCIS (Netherlands)

    Berk M; Hisschemoller M; Mol T; Hordijk L; Kok M; Metz B; NOP

    2002-01-01

    This report, Climate Change, a Permanent Concern, presents the results of research that was conducted in over 90 projects during the second phase of the National Research Programme on Global Air Pollution and Climate Change (NRP-II, 1995-2001). The report is intended for policymakers, members of

  16. Characterization of the Unusual Product from the Reaction between Cobalt(II) Chloride, Ethane-1,2-diamine, and Hydrochloric Acid: An Undergraduate Project Involving an Unknown Metal Complex.

    Science.gov (United States)

    Curtis, Neil F.; And Others

    1986-01-01

    Discusses the need for student research-type chemistry projects based upon "unknown" metal complexes. Describes an experiment involving the product from the reaction between cobalt(II) chloride, ethane-1,2-diamine (en) and concentrated hydrochloric acid. Outlines the preparation of the cobalt complex, along with procedure, results and…

  17. v-Src causes delocalization of Mklp1, Aurora B, and INCENP from the spindle midzone during cytokinesis failure

    Energy Technology Data Exchange (ETDEWEB)

    Soeda, Shuhei [Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8675 (Japan); Nakayama, Yuji, E-mail: nakayama@mb.kyoto-phu.ac.jp [Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8675 (Japan); Department of Biochemistry and Molecular Biology, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414 (Japan); Honda, Takuya; Aoki, Azumi; Tamura, Naoki; Abe, Kohei; Fukumoto, Yasunori [Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8675 (Japan); Yamaguchi, Naoto, E-mail: nyama@faculty.chiba-u.jp [Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8675 (Japan)

    2013-06-10

    Src-family tyrosine kinases are aberrantly activated in cancers, and this activation is associated with malignant tumor progression. v-Src, encoded by the v-src transforming gene of the Rous sarcoma virus, is a mutant variant of the cellular proto-oncogene c-Src. Although investigations with temperature sensitive mutants of v-Src have shown that v-Src induces many oncogenic processes, the effects on cell division are unknown. Here, we show that v-Src inhibits cellular proliferation of HCT116, HeLa S3 and NIH3T3 cells. Flow cytometry analysis indicated that inducible expression of v-Src results in an accumulation of 4N cells. Time-lapse analysis revealed that binucleation is induced through the inhibition of cytokinesis, a final step of cell division. The localization of Mklp1, which is essential for cytokinesis, to the spindle midzone is inhibited in v-Src-expressing cells. Intriguingly, Aurora B, which regulates Mklp1 localization at the midzone, is delocalized from the spindle midzone and the midbody but not from the metaphase chromosomes upon v-Src expression. Mklp2, which is responsible for the relocation of Aurora B from the metaphase chromosomes to the spindle midzone, is also lost from the spindle midzone. These results suggest that v-Src inhibits cytokinesis through the delocalization of Mklp1 and Aurora B from the spindle midzone, resulting in binucleation. -- Highlights: • v-Src inhibits cell proliferation of HCT116, HeLa S3 and NIH3T3 cells. • v-Src induces binucleation together with cytokinesis failure. • v-Src causes delocalization of Mklp1, Aurora B and INCENP from the spindle midzone.

  18. Resonant dissociation in N2 by electron impact: a source of heating in the thermosphere and auroras

    International Nuclear Information System (INIS)

    Spence, D.; Burrow, P.D.

    1979-01-01

    An electron impact resonant dissociation process, leading to superthermal atom production in molecular nitrogen is described. The maximum cross section for this process is found to be 2.5 x 10 -18 cm 2 at 10 eV. Measurements of scattered electrons indicate a value of -65 to -90 MeV for the electron affinity of N. The possible role of resonant dissociation as a source of heating in the thermosphere and in auroras is discussed

  19. Retratos de Aurora: Deconstrucción de una memoria derrumbada

    Directory of Open Access Journals (Sweden)

    Nicolás Sáez Gutiérrez

    2017-12-01

    Full Text Available Hemos decido publicar en este número el proyecto Retratos de Aurora coordinado por Walter Blas1 , como una manera de visibilizar acciones que desde el arte y su enseñanza logran transcender al entorno donde se ha efectuado dicha acción. Aquí la fotografía y el propio aparato fotográfico son el medio instrumental propuesto para construir la historia viva de la emblemática población “Aurora de Chile”.2 Las vecinas y vecinos fueron invitados por Walter a construir artesanalmente cámaras estenopeicas (sin lente adaptando objetos de su cotidiano y su memoria. Una antigua caja de madera, un lechero de aluminio, un madero de la antigua fábrica, un motor de arranque y hasta el estuche de un acordeón reliquia familiar son las formas cotidianas que se transformaron en mecanismos de captura fotográfica del propio territorio. Estos inventos caseros permitieron no solo comprender didácticamente el procedimiento técnico de la fijación química de la imagen producida por el fenómeno físico lumínico conocido como “cámara obscura”, si no que a dar un nuevo y mágico destino a estas “cámaras latentes”. Objetos que cargan con sus respectivos "relatos de existencia”, se transforman y vuelven a tener una utilidad impensada que las conecta con la intimidad familiar y la memoria colectiva. Desde ahí son operadas para construir un imaginario actualizado de lo que ha sido la población hasta hoy y para ser parte de una especie de inventario visual que prevalezca en el tiempo, como bien lo dijo Sontag “la fotografía es un inventario de la inmortalidad”.3 Las fotografías estenopeicas resultantes construyen un nuevo paisaje de la población “Aurora de Chile”. Un paisaje de resistencia, que enaltece su patrimonio humano y cultural, que activa a la memoria pasada pero que sabe construirá la futura... que desea ser un paisaje discursivo que denuncia su empoderada existencia. En nuestra actual era de la

  20. Response of Jupiter's Aurora to Plasma Mass Loading Rate Monitored by the Hisaki Satellite During Volcanic Eruptions at Io

    Science.gov (United States)

    Kimura, T.; Hiraki, Y.; Tao, C.; Tsuchiya, F.; Delamere, P. A.; Yoshioka, K.; Murakami, G.; Yamazaki, A.; Kita, H.; Badman, S. V.; Fukazawa, K.; Yoshikawa, I.; Fujimoto, M.

    2018-03-01

    The production and transport of plasma mass are essential processes in the dynamics of planetary magnetospheres. At Jupiter, it is hypothesized that Io's volcanic plasma carried out of the plasma torus is transported radially outward in the rotating magnetosphere and is recurrently ejected as plasmoid via tail reconnection. The plasmoid ejection is likely associated with particle energization, radial plasma flow, and transient auroral emissions. However, it has not been demonstrated that plasmoid ejection is sensitive to mass loading because of the lack of simultaneous observations of both processes. We report the response of plasmoid ejection to mass loading during large volcanic eruptions at Io in 2015. Response of the transient aurora to the mass loading rate was investigated based on a combination of Hisaki satellite monitoring and a newly developed analytic model. We found that the transient aurora frequently recurred at a 2-6 day period in response to a mass loading increase from 0.3 to 0.5 t/s. In general, the recurrence of the transient aurora was not significantly correlated with the solar wind, although there was an exceptional event with a maximum emission power of 10 TW after the solar wind shock arrival. The recurrence of plasmoid ejection requires the precondition that an amount comparable to the total mass of magnetosphere, 1.5 Mt, is accumulated in the magnetosphere. A plasmoid mass of more than 0.1 Mt is necessary in case that the plasmoid ejection is the only process for mass release.

  1. Specific primary sequence requirements for Aurora B kinase-mediated phosphorylation and subcellular localization of TMAP during mitosis.

    Science.gov (United States)

    Kim, Hyun-Jun; Kwon, Hye-Rim; Bae, Chang-Dae; Park, Joobae; Hong, Kyung U

    2010-05-15

    During mitosis, regulation of protein structures and functions by phosphorylation plays critical roles in orchestrating a series of complex events essential for the cell division process. Tumor-associated microtubule-associated protein (TMAP), also known as cytoskeleton-associated protein 2 (CKAP2), is a novel player in spindle assembly and chromosome segregation. We have previously reported that TMAP is phosphorylated at multiple residues specifically during mitosis. However, the mechanisms and functional importance of phosphorylation at most of the sites identified are currently unknown. Here, we report that TMAP is a novel substrate of the Aurora B kinase. Ser627 of TMAP was specifically phosphorylated by Aurora B both in vitro and in vivo. Ser627 and neighboring conserved residues were strictly required for efficient phosphorylation of TMAP by Aurora B, as even minor amino acid substitutions of the phosphorylation motif significantly diminished the efficiency of the substrate phosphorylation. Nearly all mutations at the phosphorylation motif had dramatic effects on the subcellular localization of TMAP. Instead of being localized to the chromosome region during late mitosis, the mutants remained associated with microtubules and centrosomes throughout mitosis. However, the changes in the subcellular localization of these mutants could not be completely explained by the phosphorylation status on Ser627. Our findings suggest that the motif surrounding Ser627 ((625) RRSRRL (630)) is a critical part of a functionally important sequence motif which not only governs the kinase-substrate recognition, but also regulates the subcellular localization of TMAP during mitosis.

  2. Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer

    International Nuclear Information System (INIS)

    Paller, Channing J; Wissing, Michel D; Mendonca, Janet; Sharma, Anup; Kim, Eugene; Kim, Hea-Soo; Kortenhorst, Madeleine S Q; Gerber, Stephanie; Rosen, Marc; Shaikh, Faraz; Zahurak, Marianna L; Rudek, Michelle A; Hammers, Hans; Rudin, Charles M; Carducci, Michael A; Kachhap, Sushant K

    2014-01-01

    Histone deacetylase inhibitors (HDACIs) are being tested in clinical trials for the treatment of solid tumors. While most studies have focused on the reexpression of silenced tumor suppressor genes, a number of genes/pathways are downregulated by HDACIs. This provides opportunities for combination therapy: agents that further disable these pathways through inhibition of residual gene function are speculated to enhance cell death in combination with HDACIs. A previous study from our group indicated that mitotic checkpoint kinases such as PLK1 and Aurora A are downregulated by HDACIs. We used in vitro and in vivo xenograft models of prostate cancer (PCA) to test whether combination of HDACIs with the pan-aurora kinase inhibitor AMG 900 can synergistically or additively kill PCA cells. AMG 900 and HDACIs synergistically decreased cell proliferation activity and clonogenic survival in DU-145, LNCaP, and PC3 PCA cell lines compared to single-agent treatment. Cellular senescence, polyploidy, and apoptosis was significantly increased in all cell lines after combination treatment. In vivo xenograft studies indicated decreased tumor growth and decreased aurora B kinase activity in mice treated with low-dose AMG 900 and vorinostat compared to either agent alone. Pharmacodynamics was assessed by scoring for phosphorylated histone H3 through immunofluorescence. Our results indicate that combination treatment with low doses of AMG 900 and HDACIs could be a promising therapy for future clinical trials against PCA

  3. Antifouling activity by sea anemone (Heteractis magnifica and H. aurora extracts against marine biofilm bacteria Actividades antiincrustantes de las extractos de las anémonas marinas Heteractis magnifica y H. aurora frente a biofilm de bacterias marinas

    Directory of Open Access Journals (Sweden)

    Subramanian Bragadeeswaran

    2011-07-01

    Full Text Available Sea anemones (Actiniaria are solitary, ocean-dwelling members of the phylum Cnidaria and the class Anthozoa. In this study, we screened antibacterial activity of two benthic sea anemones (Heteractis magnifica and H. aurora collected from the Mandapam coast of southeast India. Crude extracts of the sea anemone were assayed against seven bacterial biofilms isolated from three different test panels. The crude extract of H. magnifica showed a maximum inhibition zone of 18 mm against Pseudomonas sp. and Escherichia coli and a minimum inhibition zone of 3 mm against Pseudomonas aeruginosa, Micrococcus sp., and Bacillus cerens for methanol, acetone, and DCM extracts, respectively. The butanol extract of H. aurora showed a maximum inhibition zone of 23 mm against Vibrio parahaemolyticus, whereas the methanol extract revealed a minimum inhibition zone of 1 mm against V. parahaemolyticus. The present study revealed that the H. aurora extracts were more effective than those of H. magnifica and that the active compounds from the sea anemone can be used as antifouling compounds.Las anémonas de mar (Actiniaria son solitarias, habitantes oceánicos del phylum Cnidaria y de la clase Anthozoa. En este estudio se determina la actividad antibacteriana de dos anémonas bentónicas Heteractis magnifica y H. aurora recolectadas en la costa de Mandapam, sudeste de India. Los extractos crudos de estas anémonas fueron ensayados frente a siete biofilms bacterianos aislados de tres paneles de control distintos. El extracto crudo de la anémona H. magnifica mostró una zona inhibición máxima de 18 mm contra Psudomonas sp. y Escherichia coli y la zona de inhibición mínima de 3 mm fue encontrada frente a Pseudomonas aeruginosa, Micrococus sp. y Bacillus cerens de extractos de metanol, acetona y DCM respectivamente. El extracto de butanol de la anémona H. magnifica mostró una zona de inhibición máxima de 23 mm frente a Vibrio parahemolyticus, mientras que con el

  4. Advances in Neutron Activation Analysis of Large Objects with Emphasis on Archaeological Examples. Results of a Coordinated Research Project. Annex II. Companion CD-ROM

    International Nuclear Information System (INIS)

    2018-03-01

    This publication is a compilation of the main results and findings of an IAEA coordinated research project (CRP). In particular, it discusses an innovative variation of neutron activation analysis (NAA) known as large sample NAA (LSNAA). There is no other way to measure the bulk mass fractions of the elements present in a large sample (up to kilograms in mass) non-destructively. Examples amenable to LSNAA include irregularly shaped archaeological artefacts, excavated rock samples, large samples of assorted ore, and finished products, such as nuclear reactor components. Advantages of LSNAA applications, limitations and scientific and technological requirements are described in this publication, which serves as a reference of interest not only to the NAA experts, research reactor personnel, and those considering this technique, but also to various stakeholders and users such as researchers, industrialists, environmental and legal experts, and administrators. The county reports given in this companion CD-ROM (Annex II) give a global overview of all the accomplishments achieved by the participants during the CRP. However, in several cases common procedures were employed by several participating laboratories, constituting one general approach.

  5. Grid-connected integrated community energy system. Phase II, Stage 1, final report. Conceptual design, demand and fuel projections and cost analysis

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-08

    The Phase I Report, Grid ICES, presented the broad alternatives and implications for development of an energy system satisfying thermal demand with the co-generation of electric power, all predicated on the use of solid fuels. Participants of the system are the University of Minnesota, operator and primary thermal user, and Northern States Power Company, primary electrical user; with St. Mary's Hospital, Fairview Hospital, and Augsburg College as Add-on Customers for the thermal service (Option I). Included for consideration are the Options of (II) solid waste disposal by the Pyrolysis Method, with heat recovery, and (III) conversion of a portion of the thermal system from steam to hot water distribution to increase co-generation capability and as a demonstration system for future expansion. This report presents the conceptual design of the energy system and each Option, with the economic implications identified so that selection of the final system can be made. Draft outline of the Environmental Assessment for the project is submitted as a separate report.

  6. Alfvén Waves and the Aurora (Hannes Alfvén Medal Lecture)

    Science.gov (United States)

    Lysak, Robert

    2015-04-01

    The most compelling visual evidence of plasma processes in the magnetosphere of Earth as well as the other magnetized planets is the aurora. Over 40 years of research have indicated that the aurora is a consequence of the acceleration of charged particles toward the neutral atmosphere, where the excitation of neutral atoms and their subsequent relaxation to the ground state produces the auroral light. Much of this acceleration can be described by acceleration in a quasi-static electric field parallel to the geomagnetic field, producing nearly monoenergetic beams of electrons. While a variety of quasi-static models to describe such parallel electric fields have been developed, the dynamics of how these fields evolve is still an open question. Satellite measurements have indicated that a primary source of energy to support these fields is the Poynting flux associated with shear Alfvén waves propagating along auroral field lines. These Alfvén waves are generated in the magnetosphere and reflect from the ionosphere. On closed field lines, Alfvén waves bouncing between conjugate ionospheres produce field line resonances that have be observed both in space and by ground magnetometers. However, some auroral emissions do not follow this scenario. In these cases, the accelerated electrons are observed to have a broad energy spectrum, rather than a monoenergetic peak. Such a spectrum is suggestive of a time-dependent acceleration process that operates on a time scale of a few seconds, comparable to the electron transit time across the acceleration region. While field line resonances have a time scale on the order of minutes, waves with periods of a few seconds can be produced by partial reflections in the Ionospheric Alfvén Resonator, a resonant cavity formed by the rapid decrease of the plasma density and increase of the Alfvén speed above the ionosphere. In order to develop a parallel electric field that can accelerate auroral particles, these Alfvén waves must

  7. Pliocene to late Pleistocene magmatism in the Aurora Volcanic Field, Nevada and California, USA

    Science.gov (United States)

    Kingdon, S.; Cousens, B.; John, D. A.; du Bray, E. A.

    2013-12-01

    The 3.9- 0.1 Ma Aurora Volcanic Field (AVF) covers 325 km2 east and southeast of the Bodie Hills, north of Mono Lake, California, USA. The AVF is located immediately northwest of the Long Valley magmatic system and adjacent and overlapping the Miocene Bodie Hills Volcanic Field (BHVF). Rock types range from trachybasalt to trachydacite, and high-silica rhyolite. The trachybasalts to trachydacites are weakly to moderately porphyritic (1-30%) with variable phenocryst assemblages that are some combination of plagioclase, hornblende, clinopyroxene, and lesser orthopyroxene, olivine, and/or biotite. Microphenocrysts are dominated by plagioclase, and include opaque oxides, clinopyroxene, and apatite. These rocks are weakly to strongly devitrified. The high-silica rhyolites are sparsely porphyritic with trace to 10% phenocrysts of quartz, sanidine, plagioclase, biotite, (+/- hornblende), accessory opaque oxide minerals, titanite, allanite, (+/-apatite, zircon), and have glassy groundmasses. Rocks in the AVF are less strongly porphyritic than those of BHVF. Plagioclase phenocrysts are often oscillatory zoned and many have sieve texture. Amphiboles have distinct black opaque rims. Xenocrystic quartz and plagioclase are rare. AVF lavas have bimodal SiO2 compositions, ranging from 49 to 78 wt%, with a gap between 65 and 75 wt%. They are high-K calc-alkaline to shoshonitic in composition, and are metaluminous to weakly peraluminous. They are enriched in rare earth elements (REE), especially light REEs, compared to the Miocene BHVF rocks. Primordial mantle-normalized incompatible element patterns show arc- or subduction-related signatures, with enrichment in Ba and Pb, and depletion in Nb and Ta. Enrichment in K and Sr and depletion in Ti are less pronounced than in the BHVF rocks. There is no correlation between lead isotope ratios and silica (initial 206Pb/204Pb ratios range from 18.974 to 19.151). Neodymium isotope ratios show a moderate negative correlation with silica

  8. A statistical analysis of the location and width of Saturn's southern auroras

    Directory of Open Access Journals (Sweden)

    S. V. Badman

    2006-12-01

    Full Text Available A selection of twenty-two Hubble Space Telescope images of Saturn's ultraviolet auroras obtained during 1997–2004 has been analysed to determine the median location and width of the auroral oval, and their variability. Limitations of coverage restrict the analysis to the southern hemisphere, and to local times from the post-midnight sector to just past dusk, via dawn and noon. It is found that the overall median location of the poleward and equatorward boundaries of the oval with respect to the southern pole are at ~14° and ~16° co-latitude, respectively, with a median latitudinal width of ~2°. These median values vary only modestly with local time around the oval, though the poleward boundary moves closer to the pole near noon (~12.5° such that the oval is wider in that sector (median width ~3.5° than it is at both dawn and dusk (~1.5°. It is also shown that the position of the auroral boundaries at Saturn are extremely variable, the poleward boundary being located between 2° and 20° co-latitude, and the equatorward boundary between 6° and 23°, this variability contrasting sharply with the essentially fixed location of the main oval at Jupiter. Comparison with Voyager plasma angular velocity data mapped magnetically from the equatorial magnetosphere into the southern ionosphere indicates that the dayside aurora lie poleward of the main upward-directed field-aligned current region associated with corotation enforcement, which maps to ~20°–24° co-latitude, while agreeing reasonably with the position of the open-closed field line boundary based on estimates of the open flux in Saturn's tail, located between ~11° and ~15°. In this case, the variability in location can be understood in terms of changes in the open flux present in the system, the changes implied by the Saturn data then matching those observed at Earth as fractions of the total planetary flux. We infer that the broad (few degrees diffuse auroral emissions

  9. cobalt (ii), nickel (ii)

    African Journals Online (AJOL)

    DR. AMINU

    Department of Chemistry Bayero University, P. M. B. 3011, Kano, Nigeria. E-mail: hnuhu2000@yahoo.com. ABSTRACT. The manganese (II), cobalt (II), nickel (II) and .... water and common organic solvents, but are readily soluble in acetone. The molar conductance measurement [Table 3] of the complex compounds in.

  10. The Betelgeuse Project II: Asteroseismology

    Science.gov (United States)

    Nance, S.; Sullivan, J. M.; Diaz, M.; Wheeler, J. Craig

    2018-06-01

    We explore the question of whether the interior state of massive red supergiant supernova progenitors can be effectively probed with asteroseismology. We have computed a suite of ten models with ZAMS masses from 15 to 25 M⊙ in intervals of 1 M⊙ including the effects of rotation, with the stellar evolutionary code MESA. We estimate characteristic frequencies and convective luminosities of convective zones at two illustrative stages, core helium burning and off-center convective carbon burning. We also estimate the power that might be delivered to the surface to modulate the luminous output considering various efficiencies and dissipation mechanisms. The inner convective regions should generate waves with characteristic periods of ˜ 20 days in core helium burning, ˜10 days in helium shell burning, and 0.1 to 1 day in shell carbon burning. Acoustic waves may avoid both shock and diffusive dissipation relatively early in core helium burning throughout most of the structure. In shell carbon burning, years before explosion, the signal generated in the helium shell might in some circumstances be weak enough to avoid shock dissipation, but is subject to strong thermal dissipation in the hydrogen envelope. Signals from a convective carbon-burning shell are very likely to be even more severely damped by within the envelope. In the most optimistic case, early in core helium burning, waves arriving close to the surface could represent luminosity fluctuations of a few millimagnitudes, but the conditions in the very outer reaches of the envelope suggest severe thermal damping there.

  11. Trivalent dimethylarsenic compound induces histone H3 phosphorylation and abnormal localization of Aurora B kinase in HepG2 cells

    International Nuclear Information System (INIS)

    Suzuki, Toshihide; Miyazaki, Koichi; Kita, Kayoko; Ochi, Takafumi

    2009-01-01

    Trivalent dimethylarsinous acid [DMA(III)] has been shown to induce mitotic abnormalities, such as centrosome abnormality, multipolar spindles, multipolar division, and aneuploidy, in several cell lines. In order to elucidate the mechanisms underlying these mitotic abnormalities, we investigated DMA(III)-mediated changes in histone H3 phosphorylation and localization of Aurora B kinase, which is a key molecule in cell mitosis. DMA(III) caused the phosphorylation of histone H3 (ser10) and was distributed predominantly in mitotic cells, especially in prometaphase cells. By contrast, most of the phospho-histone H3 was found to be localized in interphase cells after treatment with inorganic arsenite [iAs(III)], suggesting the involvement of a different pathway in phosphorylation. DMA(III) activated Aurora B kinase and slightly activated ERK MAP kinase. Phosphorylation of histone H3 by DMA(III) was effectively reduced by ZM447439 (Aurora kinase inhibitor) and slightly reduced by U0126 (MEK inhibitor). By contrast, iAs(III)-dependent histone H3 phosphorylation was markedly reduced by U0126. Aurora B kinase is generally localized in the midbody during telophase and plays an important role in cytokinesis. However, in some cells treated with DMA(III), Aurora B was not localized in the midbody of telophase cells. These findings suggested that DMA(III) induced a spindle abnormality, thereby activating the spindle assembly checkpoint (SAC) through the Aurora B kinase pathway. In addition, cytokinesis was not completed because of the abnormal localization of Aurora B kinase by DMA(III), thereby resulting in the generation of multinucleated cells. These results provide insight into the mechanism of arsenic tumorigenesis.

  12. Structural and lithologic constraints to mineralization in Aurora, Nevada and Bodie, California mining districts, observed with aerospace geophysical data

    Science.gov (United States)

    Smailbegovic, Amer

    This study used a multifaceted approach to investigate the geology and metallogenesis of the Bodie Hills region and the Aurora mining district. The factors influencing regional- and local-scale metallogenesis are compared and discussed in context of the various datasets, analysis techniques and methodologies. The Aurora and Bodie mining districts are located in the Miocene volcanics of the Bodie Hills, north of Mono Lake, on the opposite sides of the Nevada-California state line. From the standpoint of economic geology, both deposits are structurally controlled, low-sulfidation, quartz-adularia-sericite precious metal vein deposits with an extensive alteration halo. The area has been exploited since late 1870s by both underground and minor open pit operations (Aurora), exposing portions of altered andesites, rhyolite flows and tuffs and quartz-adularia-sericite veins. Much of the previous geologic mapping and explanation in Aurora was ad-hoc and primarily in support of the mining operations, without particular interest paid to the system as a whole. Using detailed field mapping and interpretation of the deposit in Bodie as a guide, a combined array of geophysical data in conjunction with traditional field mapping and GIS-based Weights of Evidence (WofE) modeling was utilized to attain better understanding of the Aurora district and both districts in the local and regional framework. The gravity data suggests a NE-trending, positive anomaly, resulting from a density contrast between the presumably uplifted pre-Tertiary basement and Miocene volcanic assemblage in the Bodie Hills. The aeromagnetic data are dominated by the strong signature of the Miocene volcanism (vents, flows, etc.) and suggests that the volcanic activity is concentrated along the northeasterly corridor of basement uplift. Multispectral, spaceborne imagery (Landsat ETM, ASTER) shows the regional structural setting, which is dominated by NNE and NE-trending lineaments and major alteration trends in

  13. miR-137 suppresses tumor growth of malignant melanoma by targeting aurora kinase A

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Xiao; Zhang, Haiping [Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China); Lian, Shi [Department of Dermatology and Venereal Disease, Capital Medical University, Beijing 100069 (China); Zhu, Wei, E-mail: zhuwei_2020@163.com [Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China)

    2016-07-01

    As an oncogene, aurora kinase A (AURKA) is overexpressed in various types of human cancers. However, the expression and roles of AURKA in malignant melanoma are largely unknown. In this study, a miR-137-AURKA axis was revealed to regulate melanoma growth. We found a significant increase in levels of AURKA in melanoma. Both genetic knockdown and pharmacologic inhibition of AURKA decreased tumor cell growth in vitro and in vivo. Further found that miR-137 reduced AURKA expression through interaction with its 3′ untranslated region (3′UTR) and that miR-137 was negatively correlated with AURKA expression in melanoma specimens. Overexpression of miR-137 decreased cell proliferation and colony formation in vitro. Notably, re-expression of AURKA significantly rescued miR-137-mediated suppression of cell growth and clonality. In summary, these results reveal that miR-137 functions as a tumor suppressor by targeting AURKA, providing new insights into investigation of therapeutic strategies against malignant melanoma. -- Highlights: •First reported overexpression of AURKA in melanoma. •Targeting AURKA inhibits melanoma growth in vitro and in vivo. •Further found miR-137 suppressed cell growth by binding to AURKA 3′UTR. •Re-expression of AURKA rescued miR-137-mediated suppression. •miR-137-AURKA axis may be potential therapeutic targets of melanoma.

  14. Aurora: A short-pulse multikilojoule KrF inertial fusion laser system

    International Nuclear Information System (INIS)

    Rosocha, L.A.

    1985-01-01

    Aurora is a laser system that serves as an operating technology demonstration prototype for large-scale high-energy KrF laser systems of interest for inertial fusion applications. This system will incorporate the following elements to achieve an end-to-end 248-nm laser fusion concept demonstration: an injection-locked oscillator-amplifier front end; an optical angular multiplexer to produce 96 encoded optical channels each of 5-nsec duration; a chain of four electron-beam-driven KrF laser amplifiers; automated alignment systems for beam alignment; a decoder to provide for pulse compression of some fraction of the total beam train to be delivered to target, and a target chamber to house and diagnose fusion targets. The front end configuration uses a stable resonator master oscillator to drive an injection-locked unstable resonator slave oscillator. An extension of existing technology has been used to develop an electrooptic switchout at 248 nm that produces a 5-nsec pulse from the longer slave oscillator pulse. This short pulse is amplified by a postamplifier. Using these discharge lasers, the front end then delivers at least 250 mJ of KrF laser light output to the optical encoder

  15. Energetic electron precipitation in the aurora as determined by x-ray imaging

    International Nuclear Information System (INIS)

    Werden, S.C.

    1988-01-01

    This work examines two aspects of energetic-particle dynamics in the Earth's magnetosphere through the use of an x-ray imager flown from a stratospheric balloon in the auroral zone. The design and theory of this instrument is completely described, including the technique of image formation using an on-board microprocessor and a statistical analysis of the imaging process. Day-side energetic-electron precipitation is examined in the context of global energy dissipation during the substorm process. It is found that the relationship between events on the night side and the day side are considerably more complex that can be modeled with just a simple picture of drifting particles that induced instabilities, wave growth, and pitch-angle diffusion into the loss cone. The driving force for precipitation is probably not the presence of the energetic electrons (>30 keV) alone, but is influenced either by local effects or the less energetic component. The presence of small-scale structure, including gradients and complex motions in the precipitation region in the morning sector, suggests a local process influencing the rate of electron precipitation. The spatial and temporal evolution of a classic 5-15 second pulsating aurora during the post-breakup phase is also examined with the x-ray imager

  16. Combined geophysical methods for mapping infiltration pathways at the Aurora Water Aquifer recharge and recovery site

    Science.gov (United States)

    Jasper, Cameron A.

    Although aquifer recharge and recovery systems are a sustainable, decentralized, low cost, and low energy approach for the reclamation, treatment, and storage of post- treatment wastewater, they can suffer from poor infiltration rates and the development of a near-surface clogging layer within infiltration ponds. One such aquifer recharge and recovery system, the Aurora Water site in Colorado, U.S.A, functions at about 25% of its predicted capacity to recharge floodplain deposits by flooding infiltration ponds with post-treatment wastewater extracted from river bank aquifers along the South Platte River. The underwater self-potential method was developed to survey self-potential signals at the ground surface in a flooded infiltration pond for mapping infiltration pathways. A method for using heat as a groundwater tracer within the infiltration pond used an array of in situ high-resolution temperature sensing probes. Both relatively positive and negative underwater self-potential anomalies are consistent with observed recovery well pumping rates and specific discharge estimates from temperature data. Results from electrical resistivity tomography and electromagnetics surveys provide consistent electrical conductivity distributions associated with sediment textures. A lab method was developed for resistivity tests of near-surface sediment samples. Forward numerical modeling synthesizes the geophysical information to best match observed self- potential anomalies and provide permeability distributions, which is important for effective aquifer recharge and recovery system design, and optimization strategy development.

  17. Chandra's Observations of Jupiter's X-Ray Aurora During Juno Upstream and Apojove Intervals

    Science.gov (United States)

    Jackman, C.M.; Dunn, W.; Kraft, R.; Gladstone, R.; Branduardi-Raymont, G.; Knigge, C.; Altamirano, D.; Elsner, R.

    2017-01-01

    The Chandra space telescope has recently conducted a number of campaigns to observe Jupiter's X-ray aurora. The first set of campaigns took place in summer 2016 while the Juno spacecraft was upstream of the planet sampling the solar wind. The second set of campaigns took place in February, June and August 2017 at times when the Juno spacecraft was at apojove (expected close to the magnetopause). We report on these upstream and apojove campaigns including intensities and periodicities of auroral X-ray emissions. This new era of jovian X-ray astronomy means we have more data than ever before, long observing windows (up to 72 kiloseconds for this Chandra set), and successive observations relatively closely spaced in time. These features combine to allow us to pursue novel methods for examining periodicities in the X-ray emission. Our work will explore significance testing of emerging periodicities, and the search for coherence in X-ray pulsing over weeks and months, seeking to understand the robustness and regularity of previously reported hot spot X-ray emissions. The periods that emerge from our analysis will be compared against those which emerge from radio and UV wavelengths.

  18. Genomic organization, expression, and chromosome localization of a third aurora-related kinase gene, Aie1.

    Science.gov (United States)

    Hu, H M; Chuang, C K; Lee, M J; Tseng, T C; Tang, T K

    2000-11-01

    We previously reported two novel testis-specific serine/threonine kinases, Aie1 (mouse) and AIE2 (human), that share high amino acid identities with the kinase domains of fly aurora and yeast Ipl1. Here, we report the entire intron-exon organization of the Aie1 gene and analyze the expression patterns of Aie1 mRNA during testis development. The mouse Aie1 gene spans approximately 14 kb and contains seven exons. The sequences of the exon-intron boundaries of the Aie1 gene conform to the consensus sequences (GT/AG) of the splicing donor and acceptor sites of most eukaryotic genes. Comparative genomic sequencing revealed that the gene structure is highly conserved between mouse Aie1 and human AIE2. However, much less homology was found in the sequence outside the kinase-coding domains. The Aie1 locus was mapped to mouse chromosome 7A2-A3 by fluorescent in situ hybridization. Northern blot analysis indicates that Aie1 mRNA likely is expressed at a low level on day 14 and reaches its plateau on day 21 in the developing postnatal testis. RNA in situ hybridization indicated that the expression of the Aie1 transcript was restricted to meiotically active germ cells, with the highest levels detected in spermatocytes at the late pachytene stage. These findings suggest that Aie1 plays a role in spermatogenesis.

  19. Superthermal Electron Magnetosphere-Ionosphere Coupling in the Diffuse Aurora in the Presence of ECH Waves

    Science.gov (United States)

    Khazanov, G. V.; Tripathi, A. K.; Singhal, R. P.; Himwich, Elizabeth; Glocer, A.; Sibeck, D. G.

    2015-01-01

    There are two main theories for the origin of the diffuse auroral electron precipitation: first, pitch angle scattering by electrostatic electron cyclotron harmonic (ECH) waves, and second, by whistler mode waves. Precipitating electrons initially injected from the plasma sheet to the loss cone via wave-particle interaction processes degrade in the atmosphere toward lower energies and produce secondary electrons via impact ionization of the neutral atmosphere. These secondary electrons can escape back to the magnetosphere, become trapped on closed magnetic field lines, and deposit their energy back to the inner magnetosphere. ECH and whistler mode waves can also move electrons in the opposite direction, from the loss cone into the trap zone, if the source of such electrons exists in conjugate ionospheres located at the same field lines as the trapped magnetospheric electron population. Such a situation exists in the simulation scenario of superthermal electron energy interplay in the region of diffuse aurora presented and discussed by Khazanov et al. (2014) and will be quantified in this paper by taking into account the interaction of secondary electrons with ECH waves.

  20. Ionosphere-Magnetosphere Energy Interplay in the Regions of Diffuse Aurora

    Science.gov (United States)

    Khazanov, G. V.; Glocer, A.; Sibeck, D. G.; Tripathi, A. K.; Detweiler, L.G.; Avanov, L. A.; Singhal, R. P.

    2016-01-01

    Both electron cyclotron harmonic (ECH) waves and whistler mode chorus waves resonate with electrons of the Earths plasma sheet in the energy range from tens of eV to several keV and produce the electron diffuse aurora at ionospheric altitudes. Interaction of these superthermal electrons with the neutral atmosphere leads to the production of secondary electrons (E500600 eV) and, as a result, leads to the activation of lower energy superthermal electron spectra that can escape back to the magnetosphere and contribute to the thermal electron energy deposition processes in the magnetospheric plasma. The ECH and whistler mode chorus waves, however, can also interact with the secondary electrons that are coming from both of the magnetically conjugated ionospheres after they have been produced by initially precipitated high-energy electrons that came from the plasma sheet. After their degradation and subsequent reflection in magnetically conjugate atmospheric regions, both the secondary electrons and the precipitating electrons with high (E600 eV) initial energies will travel back through the loss cone, become trapped in the magnetosphere, and redistribute the energy content of the magnetosphere-ionosphere system. Thus, scattering of the secondary electrons by ECH and whistler mode chorus waves leads to an increase of the fraction of superthermal electron energy deposited into the core magnetospheric plasma.

  1. Climate and surface water hydrology baseline data for Aurora Mine EIA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    A climate and hydrology database was assembled to describe the existing climatic and surface water hydrological characteristics of the proposed Aurora Mine area in Leases 10, 12, 13, 31, and 34 east of the Athabasca River near Fort McKay. The study was based upon data available from the regional hydrometeorological monitoring network operated by the Governments of Canada and Alberta. The study also included the installation and monitoring of one climate station and five streamflow gauging stations on small watersheds in the area. The representative climatic and hydrologic characteristics of the area, including precipitation, evaporation, evapotranspiration, temperature and wind, were determined. Streamflow characteristics such as flood frequencies, low flow frequencies, water yield and flow durations representative of large gauged watersheds within the study area were also determined. The results offer a good basis for preliminary design of surface water management systems. It was recommended that the monitoring program should be continued to monitor potential environmental impacts of proposed development activities. 9 refs., 29 tabs., 32 figs.

  2. Design and implementation of the GPS subsystem for the Radio Aurora eXplorer

    Science.gov (United States)

    Spangelo, Sara C.; Bennett, Matthew W.; Meinzer, Daniel C.; Klesh, Andrew T.; Arlas, Jessica A.; Cutler, James W.

    2013-06-01

    This paper presents the design and implementation of the Global Positioning System (GPS) subsystem for the Radio Aurora eXplorer (RAX) CubeSat. The GPS subsystem provides accurate temporal and spatial information necessary to satisfy the science objectives of the RAX mission. There are many challenges in the successful design and implementation of a GPS subsystem for a CubeSat-based mission, including power, size, mass, and financial constraints. This paper presents an approach for selecting and testing the individual and integrated GPS subsystem components, including the receiver, antenna, low noise amplifier, and supporting circuitry. The procedures to numerically evaluate the GPS link budget and test the subsystem components at various stages of system integration are described. Performance results for simulated tests in the terrestrial and orbital environments are provided, including start-up times, carrier-to-noise ratios, and orbital position accuracy. Preliminary on-orbit GPS results from the RAX-1 and RAX-2 spacecraft are presented to validate the design process and pre-flight simulations. Overall, this paper provides a systematic approach to aid future satellite designers in implementing and verifying GPS subsystems for resource-constrained small satellites.

  3. Cross-Field Current Instabilities in Thin Ionization Layers and the Enhanced Aurora

    International Nuclear Information System (INIS)

    Johnson, Jay R.; Okuda, Hideo

    2008-01-01

    Nearly half of the time, auroral displays exhibit thin, bright layers known as 'enhanced aurora'. There is a substantial body of evidence that connects these displays with thin, dense, heavy ion layers in the E-region. Based on the spectral characteristics of the enhanced layers, it is believed that they result when wave-particle interaction heats ambient electrons to energies at or just above the 17 eV ionization energy of N2. While there are several possible instabilities that could produce suprathermal electrons in thin layers, there has been no clear theoretical investigation which examines in detail how wave instabilities in the thin ionization layers could develop and produce the suprathermal electrons. We examine instabilities which would occur in thin, dense, heavy ion layers using extensive analytical analysis combined with particle simulations. We analyze a cross field current instability that is found to be strongly unstable in the heavy ion layers. Electrostatic simulations show that substantial heating of the ambient electrons occurs with energization at or above the N2 ionization energy.

  4. Feasibility Study of Economics and Performance of Solar Photovoltaics at the Tower Road Site in Aurora, Colorado. A Study Prepared in Partnership with the Environmental Protection Agency for the RE-Powering America's Land Initiative: Siting Renewable Energy on Potentially Contaminated Land and Mine Sites

    Energy Technology Data Exchange (ETDEWEB)

    Van Geet, O.; Mosey, G.

    2013-03-01

    The U.S. Environmental Protection Agency (EPA), in accordance with the RE-Powering America's Land initiative, selected the Tower Road site in Aurora, Colorado, for a feasibility study of renewable energy production. The National Renewable Energy Laboratory (NREL) provided technical assistance for this project. The purpose of this report is to assess the site for a possible photovoltaic (PV) system installation and estimate the cost, performance, and site impacts of different PV options. In addition, the report recommends financing options that could assist in the implementation of a PV system at the site. This study did not assess environmental conditions at the site.

  5. Aerospace Systems Monitor, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Proposal Title: Aerospace Systems Monitor PHASE 1 Technical Abstract: This Phase II STTR project will continue development and commercialization of the Aerospace...

  6. Utilització de concursos de robòtica d’àmbit internacional per a l’assignatura Projecte integrat II del Grau en Enginyeria Mecatrònica a la UVic

    OpenAIRE

    Reig Bolaño, Ramon; Armengol Vila, Xavier; Domènech Mestres, Carles; Serra Espaulella, Jordi

    2013-01-01

    Aquesta comunicació posa en comú la metodologia de treball de l’assignatura Projecte Integrat II del Grau en Enginyeria Mecatrònica de la UVIC, assignatura del segon semestre del 3r. curs que integra les diferents disciplines del grau: el disseny mecànic, el disseny electrònic, la programació de dispositius, la planificació i execució de projectes mecatrònics i el contacte amb la realitat empresarial. S’ha realitzat una combinació equilibrada de l’esperit i les formes dels concursos de robòti...

  7. Variations in energy, flux, and brightness of pulsating aurora measured at high time resolution

    Directory of Open Access Journals (Sweden)

    H. Dahlgren

    2017-03-01

    Full Text Available High-resolution multispectral optical and incoherent scatter radar data are used to study the variability of pulsating aurora. Two events have been analysed, and the data combined with electron transport and ion chemistry modelling provide estimates of the energy and energy flux during both the ON and OFF periods of the pulsations. Both the energy and energy flux are found to be reduced during each OFF period compared with the ON period, and the estimates indicate that it is the number flux of foremost higher-energy electrons that is reduced. The energies are found never to drop below a few kilo-electronvolts during the OFF periods for these events. The high-resolution optical data show the occurrence of dips in brightness below the diffuse background level immediately after the ON period has ended. Each dip lasts for about a second, with a reduction in brightness of up to 70 % before the intensity increases to a steady background level again. A different kind of variation is also detected in the OFF period emissions during the second event, where a slower decrease in the background diffuse emission is seen with its brightness minimum just before the ON period, for a series of pulsations. Since the dips in the emission level during OFF are dependent on the switching between ON and OFF, this could indicate a common mechanism for the precipitation during the ON and OFF phases. A statistical analysis of brightness rise, fall, and ON times for the pulsations is also performed. It is found that the pulsations are often asymmetric, with either a slower increase of brightness or a slower fall.

  8. Vortex, ULF wave and Aurora Observation after Solar Wind Dynamic Pressure Change

    Science.gov (United States)

    Shi, Q.

    2017-12-01

    Here we will summarize our recent study and show some new results on the Magnetosphere and Ionosphere Response to Dynamic Pressure Change/disturbances in the Solar Wind and foreshock regions. We study the step function type solar wind dynamic pressure change (increase/decrease) interaction with the magnetosphere using THEMIS satellites at both dayside and nightside in different geocentric distances. Vortices generated by the dynamic pressure change passing along the magnetopause are found and compared with model predictions. ULF waves and vortices are excited in the dayside and nightside plasma sheet when dynamic pressure change hit the magnetotail. The related ionospheric responses, such as aurora and TCVs, are also investigated. We compare Global MHD simulations with the observations. We will also show some new results that dayside magnetospheric FLRs might be caused by foreshock structures.Shi, Q. Q. et al. (2013), THEMIS observations of ULF wave excitation in the nightside plasma sheet during sudden impulse events, J. Geophys. Res. Space Physics, 118, doi:10.1029/2012JA017984. Shi, Q. Q. et al. (2014), Solar wind pressure pulse-driven magnetospheric vortices and their global consequences, J. Geophys. Res. Space Physics, 119, doi:10.1002/2013JA019551. Tian, A.M. et al.(2016), Dayside magnetospheric and ionospheric responses to solar wind pressure increase: Multispacecraft and ground observations, J. Geophys. Res., 121, doi:10.1002/2016JA022459. Shen, X.C. et al.(2015), Magnetospheric ULF waves with increasing amplitude related to solar wind dynamic pressure changes: THEMIS observations, J. Geophys. Res., 120, doi:10.1002/2014JA020913Zhao, H. Y. et al. (2016), Magnetospheric vortices and their global effect after a solar wind dynamic pressure decrease, J. Geophys. Res. Space Physics, 121, doi:10.1002/2015JA021646. Shen, X. C., et al. (2017), Dayside magnetospheric ULF wave frequency modulated by a solar wind dynamic pressure negative impulse, J. Geophys. Res

  9. Chandra observations of Jupiter's X-ray Aurora during Juno upstream and apojove intervals

    Science.gov (United States)

    Dunn, W.; Jackman, C. M.; Kraft, R.; Gladstone, R.; Branduardi-Raymont, G.; Knigge, C.; Altamirano, D.; Elsner, R.; Kammer, J.

    2017-12-01

    The Chandra space telescope has recently conducted a number of campaigns to observe Jupiter's X-ray aurora. The first set of campaigns took place in summer 2016 while the Juno spacecraft was upstream of the planet sampling the solar wind. The second set of campaigns took place in February, June and August 2017 at times when the Juno spacecraft was at apojove. These campaigns were planned following the Juno orbit correction to capitalise on the opportunity to image the X-ray emission while Juno was orbiting close to the expected position of the magnetopause. Previous work has suggested that the auroral X-ray emissions map close to the magnetopause boundary [e.g. Vogt et al., 2015; Kimura et al., 2016; Dunn et al., 2016] and thus in situ spacecraft coverage in this region combined with remote observation of the X-rays afford the chance to constrain the drivers of these energetic emissions and determine if they originate on open or closed field lines. We aim to examine possible drivers of X-ray emission including reconnection and the Kelvin-Helmholtz instability and to explore the role of the solar wind in controlling the emissions. We report on these upstream and apojove campaigns including intensities and periodicities of auroral X-ray emissions. This new era of jovian X-ray astronomy means we have more data than ever before, long observing windows (up to 72 ks for this Chandra set), and successive observations relatively closely spaced in time. These features combine to allow us to pursue novel methods for examining periodicities in the X-ray emission. Our work will explore significance testing of emerging periodicities, and the search for coherence in X-ray pulsing over weeks and months, seeking to understand the robustness and regularity of previously reported hot spot X-ray emissions. The periods that emerge from our analysis will be compared against those which emerge from radio and UV wavelengths.

  10. Amplification and overexpression of aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells.

    Science.gov (United States)

    Chung, C M; Man, C; Jin, Y; Jin, C; Guan, X Y; Wang, Q; Wan, T S K; Cheung, A L M; Tsao, S W

    2005-07-01

    Immortalization is an early and essential step of human carcinogenesis. Amplification of chromosome 20q has been shown to be a common event in immortalized cells and cancers. We have previously reported that gain and amplification of chromosome 20q is a non-random and common event in immortalized human ovarian surface epithelial (HOSE) cells. The chromosome 20q harbors genes including TGIF2 (20q11.2-q12), AIB1 (20q12), PTPN1 (20q13.1), ZNF217 (20q13.2), and AURKA (20q13.2-q13.3), which were previously reported to be amplified and overexpressed in ovarian cancers. Some of these genes may be involved in immortalization of HOSE cells and represent crucial premalignant changes in ovarian surface epithelium. Investigation of the involvement of these genes was examined in four pairs of pre-crisis (preimmortalized) and post-crisis (immortalized) HOSE cells. Overexpression of AURKA (Aurora kinase A), also known as BTAK and STK15, by both real time-quantitative polymerase chain reaction (RT-QPCR) and Western blotting was detected in all the four immortalized HOSE cells examined while overexpression of AIB1 and ZNF217 was observed in two of four immortalized HOSE cells examined. Overexpression of TGIF2 and PTPN1 was not significant in our immortalized HOSE cell systems. The degree of overexpression of AURKA was shown to be closely associated with the amplification of chromosome 20q in immortalized HOSE cells. Fluorescence in situ hybridization (FISH) with labeled P1 artificial clone (PAC) confirmed the amplification of the chromosomal region (20q13.2-13.3) where AURKA resides. DNA amplification of AURKA was also confirmed using semi-quantitative PCR. Our study showed that amplification and overexpression of AURKA is a common and significant event during immortalization of HOSE cells and may represent an important premalignant change in ovarian carcinogenesis. Copyright (c) 2005 Wiley-Liss, Inc.

  11. Representation of the Indian in Calderón’s «La Aurora en Copacabana»

    Directory of Open Access Journals (Sweden)

    José Elías Gutiérrez Meza

    2014-11-01

    Full Text Available The article analyzes the onomastics of the Indian characters, the portrayal of the Inca Empire of Huáscar and Atahualpa, and the Christianization of Guacolda and Yupangui in Calderón’s La Aurora en Copacabana. Rational and proactive, these two characters realize the illegitimacy of the Inca idolatry and embrace the true religion, long before the formal start of Perú’s christianization. Thus, it is argued that this specific representation of the Indian may have been influenced by the close circles indianos of Miguel de Aguirre, who allegedly patronized this comedy.

  12. Aurora Bosna, Scautismo femminile e Guidismo. Esperienze educative in prospettiva di Genere: i casi dell'Italia e della Spagna

    Directory of Open Access Journals (Sweden)

    Lucia Tortora

    2015-03-01

    pp. 291 La recensione presenta il volume Scautismo femminile e Guidismo. Esperienze educative in prospettiva di Genere: i casi dell'Italia e della Spagna di Aurora Bosna, che analizza i fenomeni dello Scautismo femminile e del Guidismo in una prospettiva comparatstica e in un'ottica pedagogica e di genere, evidenziando il valore che tali esperienze hanno avuto nel percorso di emancipazione femminile all'interno dei contesti socio-culturali dell'Italia e della Spagna tra il XIX e il XX secolo.

  13. Geophysical Investigation using Two Dimensional Electrical Resistivity Tomography method to delineate Subsurface Geological Structures at Dudhkoshi-II (230 MW) Hydroelectric Project, Solukhumbu District, Eastern Nepal

    Science.gov (United States)

    Ghimire, H.; Bhusal, U. C.; Khatiwada, B.; Pandey, D.

    2017-12-01

    Geophysical investigation using two dimensional electrical resistivity tomography (2D-ERT) method plays a significant role in determining the subsurface resistivity distribution by making measurement on the ground surface. This method was carried out at Dudhkoshi-II (230 MW) Hydroelectric Project, lies on Lesser Himalayan region of the Eastern Nepal to delineate the nature of the subsurface geology to assess its suitability for the construction of dam, desanding basin and powerhouse. The main objective of the proposed study consists of mapping vertical as well as horizontal variations of electrical resistivity to enable detection of the boundaries between unconsolidated materials and rocks of the different resistivity, possible geologic structures, such as possible presence of faults, fractures, and voids in intake and powerhouse area. For this purpose, the (WDJD-4 Multi-function Digital DC Resistivity/IP) equipment was used with Wenner array (60 electrodes). To fulfill these objectives of the study, the site area was mapped by Nine ERT profiles with different profile length and space between electrodes was 5 m. The depth of the investigation was 50 m. The acquired data were inverted to tomogram sections using tomographic inversion with RES2DINV commercial software. The Tomography sections show that the subsurface is classified into distinct geo-electric layers of dry unconsolidated overburden, saturated overburden, fractured rock and fresh bedrock of phyllites with quartzite and gneiss with different resistivity values. There were no voids and faults in the study area. Thickness of overburden at different region found to be different. Most of the survey area has bedrock of phyllites with quartzite; gneiss is also present in some location at intake area. Bedrock is found at the varies depth of 5-8 m at dam axis, 20-32 m at desanding basin and 3-10 m at powerhouse area. These results are confirmed and verified by using several boreholes data were drilled on the

  14. Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: selective inhibitors of Aurora B kinase with potent anti-tumor activity.

    Science.gov (United States)

    Foote, Kevin M; Mortlock, Andrew A; Heron, Nicola M; Jung, Frédéric H; Hill, George B; Pasquet, Georges; Brady, Madeleine C; Green, Stephen; Heaton, Simon P; Kearney, Sarah; Keen, Nicholas J; Odedra, Rajesh; Wedge, Stephen R; Wilkinson, Robert W

    2008-03-15

    A new class of 1-acetanilide-4-aminopyrazole-substituted quinazoline Aurora kinase inhibitors has been discovered possessing highly potent cellular activity. Continuous infusion into athymic mice bearing SW620 tumors of the soluble phosphate derivative 2 led to dose-proportional exposure of the des-phosphate compound 8 with a high-unbound fraction. The combination of potent cell activity and high free-drug exposure led to pharmacodynamic changes in the tumor at low doses, indicative of Aurora B-kinase inhibition and a reduction in tumor volume.

  15. Educational Project Management Instructional System. Module Two. Project Management Basic Principles. Volume I--Lessons 1 to 6. Volume II--Lessons 7 to 12. Volume III--Case Simulation.

    Science.gov (United States)

    Cummings, C. Peter; Cook, Desmond L.

    This module is the second in a self-instructional program designed to train public school personnel in how to manage educational projects. The purpose of this module is to provide current or potential project directors with the basic knowledge, skills, abilities, and sensitivities needed to manage a local educational project. In the areas of…

  16. Geologic and porous media factors affecting the 2007 production response characteristics of the JOGMEC/NRCan/AURORA Mallik gas hydrate production research well

    Energy Technology Data Exchange (ETDEWEB)

    Dallimore, S. R.; Wright, J. F.; Nixon, F. M. [Natural Resources Canada, Sidney, BC (Canada). Geological Survey of Canada; Kurihara, M. [Japan Oil Engineering, Tokyo (Japan); Yamamoto, K.; Fujii, T.; Fujii, K.; Numasawa, M.; Yasuda, M. [Japan Oil, Gas, Metals National Corp., Chiba (Japan). Technical Research Centre; Imasato, Y. [Schlumberger K.K., Fuchinombe (Japan)

    2008-07-01

    The joint research project between Japan Oil, Gas and Metals National Corporation (JOGMEC), Natural Resources Canada (NRCan) and the Aurora Research Institute was conducted in an effort to measure and monitor the response of a terrestrial gas hydrate reservoir to pressure draw down. This paper reviewed the geologic setting and porous media conditions of a concentrated gas hydrate production interval between 1093 and 1105 m. The short-duration production test was conducted at the Mallik site in Canada's Mackenzie Delta in April 2007. The production interval consists of a sand-dominated succession with occasional silty sand interbeds. Gas hydrate occurs primarily within the sediment pore spaces, with concentrations ranging between 50-90 per cent. Experiments on pore water salinity and porous media conditions on pressure-temperature stability suggest that the partition between gas hydrate stability and instability should be considered as a phase boundary zone rather than a discrete threshold. The experiment revealed that there are significant changes to the physical properties following gas hydrate dissociation, with sediments containing no hydrate behaving as unconsolidated sands. A strong reservoir response to pressure draw down was observed with increasing gas flow during the testing period. Sand inflow to the well during the test may be attributed to loss of sediment strength during gas hydrate dissociation, with the sediment behaving as a gasified slurry. It was concluded that the gas flow response observed during the 2007 production test at Mallik was highly influenced by porous media properties and by the geological heterogeneities which may initiate high permeability conduits in sediments within the production interval of the Mallik gas hydrate reservoir. 18 refs., 6 figs.

  17. Cold storage of peaches cv. Aurora grown in the Zona da Mata Mineira, Minas Gerais State, Brazil

    Directory of Open Access Journals (Sweden)

    Danielle Fabíola Pereira Silva

    2013-12-01

    Full Text Available This study aimed to evaluate the postharvest behavior of peach cv. Aurora 1 harvested in the Zona da Mata region of Minas Gerais in two ripening stages and kept under different storage temperatures. Fruits on mid-ripe and fully ripe stages were stored at three temperatures: 5.6 ± 1.57 °C and 72.8 ± 3.8% RH; 10.4 ± 0.5 °C and 95.8 ± 5.5% RH; 21.04 ± 1.63 °C and 96.9 ± 2.6% RH up to 28 storage days (SD . During storage, fruits stored at 21.04 ± 1.63 °C were evaluated every two days until 8 SD, and every four days for fruits stored at other temperatures. The harvest day was assigned as day zero. The variables evaluated were CO2 production, color of the pericarp and pulp, fresh mass loss, flesh firmness, total soluble solids, titratable acidity, contents of ascorbic acid and carotenoids. The fresh mass loss increased during storage, peaking at 5.6 °C. The reduction in ascorbic acid content was higher in fully ripe fruits at all temperatures. Mid-ripe fruits reached the end of the storage period with better quality. The temperature of 10.4 °C was the most efficient in keeping postharvest quality of peach cv. Aurora 1 harvested in the Zona da Mata region.

  18. The mitosis-regulating and protein-protein interaction activities of astrin are controlled by aurora-A-induced phosphorylation.

    Science.gov (United States)

    Chiu, Shao-Chih; Chen, Jo-Mei Maureen; Wei, Tong-You Wade; Cheng, Tai-Shan; Wang, Ya-Hui Candice; Ku, Chia-Feng; Lian, Chiao-Hsuan; Liu, Chun-Chih Jared; Kuo, Yi-Chun; Yu, Chang-Tze Ricky

    2014-09-01

    Cells display dramatic morphological changes in mitosis, where numerous factors form regulatory networks to orchestrate the complicated process, resulting in extreme fidelity of the segregation of duplicated chromosomes into two daughter cells. Astrin regulates several aspects of mitosis, such as maintaining the cohesion of sister chromatids by inactivating Separase and stabilizing spindle, aligning and segregating chromosomes, and silencing spindle assembly checkpoint by interacting with Src kinase-associated phosphoprotein (SKAP) and cytoplasmic linker-associated protein-1α (CLASP-1α). To understand how Astrin is regulated in mitosis, we report here that Astrin acts as a mitotic phosphoprotein, and Aurora-A phosphorylates Astrin at Ser(115). The phosphorylation-deficient mutant Astrin S115A abnormally activates spindle assembly checkpoint and delays mitosis progression, decreases spindle stability, and induces chromosome misalignment. Mechanistic analyses reveal that Astrin phosphorylation mimicking mutant S115D, instead of S115A, binds and induces ubiquitination and degradation of securin, which sequentially activates Separase, an enzyme required for the separation of sister chromatids. Moreover, S115A fails to bind mitosis regulators, including SKAP and CLASP-1α, which results in the mitotic defects observed in Astrin S115A-transfected cells. In conclusion, Aurora-A phosphorylates Astrin and guides the binding of Astrin to its cellular partners, which ensures proper progression of mitosis. Copyright © 2014 the American Physiological Society.

  19. The variations of oxygen emissions in corresponding to Earth's aurora in low latitude region under influence of solar wind dynamics

    Science.gov (United States)

    Jamlongkul, P.; Wannawichian, S.

    2017-12-01

    Earth's aurora in low latitude region was studied via time variations of oxygen emission spectra, simultaneously with solar wind data. The behavior of spectrum intensity, in corresponding with solar wind condition, could be a trace of aurora in low latitude region including some effects of high energetic auroral particles. Oxygen emission spectral lines were observed by Medium Resolution Echelle Spectrograph (MRES) at 2.4-m diameter telescope at Thai National Observatory, Inthanon Mountain, Chiang Mai, Thailand, during 1-5 LT on 5 and 6 February 2017. The observed spectral lines were calibrated via Dech95 - 2D image processing program and Dech-Fits spectra processing program for spectrum image processing and spectrum wavelength calibration, respectively. The variations of observed intensities each day were compared with solar wind parameters, which are magnitude of IMF (|BIMF|) including IMF in RTN coordinate (BR, BT, BN), ion density (ρ), plasma flow pressure (P), and speed (v). The correlation coefficients between oxygen spectral emissions and different solar wind parameters were found to vary in both positive and negative behaviors.

  20. An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B.

    Science.gov (United States)

    Winter, Georg E; Rix, Uwe; Lissat, Andrej; Stukalov, Alexey; Müllner, Markus K; Bennett, Keiryn L; Colinge, Jacques; Nijman, Sebastian M; Kubicek, Stefan; Kovar, Heinrich; Kontny, Udo; Superti-Furga, Giulio

    2011-10-01

    Ewing's sarcoma is a pediatric cancer of the bone that is characterized by the expression of the chimeric transcription factor EWS-FLI1 that confers a highly malignant phenotype and results from the chromosomal translocation t(11;22)(q24;q12). Poor overall survival and pronounced long-term side effects associated with traditional chemotherapy necessitate the development of novel, targeted, therapeutic strategies. We therefore conducted a focused viability screen with 200 small molecule kinase inhibitors in 2 different Ewing's sarcoma cell lines. This resulted in the identification of several potential molecular intervention points. Most notably, tozasertib (VX-680, MK-0457) displayed unique nanomolar efficacy, which extended to other cell lines, but was specific for Ewing's sarcoma. Furthermore, tozasertib showed strong synergies with the chemotherapeutic drugs etoposide and doxorubicin, the current standard agents for Ewing's sarcoma. To identify the relevant targets underlying the specific vulnerability toward tozasertib, we determined its cellular target profile by chemical proteomics. We identified 20 known and unknown serine/threonine and tyrosine protein kinase targets. Additional target deconvolution and functional validation by RNAi showed simultaneous inhibition of Aurora kinases A and B to be responsible for the observed tozasertib sensitivity, thereby revealing a new mechanism for targeting Ewing's sarcoma. We further corroborated our cellular observations with xenograft mouse models. In summary, the multilayered chemical biology approach presented here identified a specific vulnerability of Ewing's sarcoma to concomitant inhibition of Aurora kinases A and B by tozasertib and danusertib, which has the potential to become a new therapeutic option.