WorldWideScience

Sample records for program lkb resources

  1. Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.

    Science.gov (United States)

    Faubert, Brandon; Vincent, Emma E; Griss, Takla; Samborska, Bozena; Izreig, Said; Svensson, Robert U; Mamer, Orval A; Avizonis, Daina; Shackelford, David B; Shaw, Reuben J; Jones, Russell G

    2014-02-18

    One of the major metabolic changes associated with cellular transformation is enhanced nutrient utilization, which supports tumor progression by fueling both energy production and providing biosynthetic intermediates for growth. The liver kinase B1 (LKB1) is a serine/threonine kinase and tumor suppressor that couples bioenergetics to cell-growth control through regulation of mammalian target of rapamycin (mTOR) activity; however, the influence of LKB1 on tumor metabolism is not well defined. Here, we show that loss of LKB1 induces a progrowth metabolic program in proliferating cells. Cells lacking LKB1 display increased glucose and glutamine uptake and utilization, which support both cellular ATP levels and increased macromolecular biosynthesis. This LKB1-dependent reprogramming of cell metabolism is dependent on the hypoxia-inducible factor-1α (HIF-1α), which accumulates under normoxia in LKB1-deficient cells and is antagonized by inhibition of mTOR complex I signaling. Silencing HIF-1α reverses the metabolic advantages conferred by reduced LKB1 signaling and impairs the growth and survival of LKB1-deficient tumor cells under low-nutrient conditions. Together, our data implicate the tumor suppressor LKB1 as a central regulator of tumor metabolism and growth control through the regulation of HIF-1α-dependent metabolic reprogramming.

  2. Bridge resource program.

    Science.gov (United States)

    2013-09-01

    The mission of Rutgers Universitys Center for Advanced Infrastructure and Transportation (CAIT) Bridge Resource Program (BRP) is to provide bridge engineering support to the New Jersey Department of Transportation (NJDOT)s Bridge Engineering an...

  3. NASA Water Resources Program

    Science.gov (United States)

    Toll, David L.

    2011-01-01

    With increasing population pressure and water usage coupled with climate variability and change, water issues are being reported by numerous groups as the most critical environmental problems facing us in the 21st century. Competitive uses and the prevalence of river basins and aquifers that extend across boundaries engender political tensions between communities, stakeholders and countries. In addition to the numerous water availability issues, water quality related problems are seriously affecting human health and our environment. The potential crises and conflicts especially arise when water is competed among multiple uses. For example, urban areas, environmental and recreational uses, agriculture, and energy production compete for scarce resources, not only in the Western U.S. but throughout much of the U.S. and also in numerous parts of the world. Mitigating these conflicts and meeting water demands and needs requires using existing water resources more efficiently. The NASA Water Resources Program Element works to use NASA products and technology to address these critical water issues. The primary goal of the Water Resources is to facilitate application of NASA Earth science products as a routine use in integrated water resources management for the sustainable use of water. This also includes the extreme events of drought and floods and the adaptation to the impacts from climate change. NASA satellite and Earth system observations of water and related data provide a huge volume of valuable data in both near-real-time and extended back nearly 50 years about the Earth's land surface conditions such as precipitation, snow, soil moisture, water levels, land cover type, vegetation type, and health. NASA Water Resources Program works closely to use NASA and Earth science data with other U.S. government agencies, universities, and non-profit and private sector organizations both domestically and internationally. The NASA Water Resources Program organizes its

  4. 14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function.

    Science.gov (United States)

    Bai, Yu; Zhou, Tao; Fu, Haian; Sun, Hanyan; Huang, Bei

    2012-04-24

    Here we report a regulatory mechanism by which LKB1 is controlled by 14-3-3 proteins through phorsphorylation of Thr336. The results from the current study indicate that 14-3-3 ζ inhibits LKB1 from phosphorylating its substrate, AMPK (AMP-dependent protein kinase) and attenuates LKB1-mediated G1 cell cycle arrest and apoptosis by interfering with the interaction between LKB1 and its substrates. This regulation does not change either the LKB1 catalytic activity or subcellular localization of LKB1. Moreover, we demonstrate that serum starvation enhances LKB1 activity and increases the phosphorylation of Thr336. Taken together, our results suggest that autophosphorylation of Thr336 acts as an activating signal for LKB1 to recruit 14-3-3, which in turn attenuates the activation of LKB1 to keep the activity of LKB1 in check. Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  5. LKB1; linking cell structure and tumor suppression.

    Science.gov (United States)

    Hezel, A F; Bardeesy, N

    2008-11-24

    Germ line mutations in the LKB1 tumor suppressor gene are associated with the Peutz-Jeghers polyposis and cancer syndrome. Somatic mutations in Lkb1 are observed in sporadic pulmonary, pancreatic and biliary cancers and melanomas. The LKB1 serine-threonine kinase functionally and biochemically links control of cellular structure and energy utilization through activation of the AMPK family of kinases. Lkb1 regulates cell polarity through downstream kinases including AMPKs, MARKs and BRSKs, and nutrient utilization and cellular metabolism through the AMPK-mTOR pathway. LKB1 has been shown to affect normal chromosomal segregation, TGF-beta signaling in the mesenchyme and WNT and p53 activity. Although each of the LKB1-dependent processes and downstream pathways have been individually delineated through work across a range of experimental systems, how they relate to Lkb1's role as a tumor suppressor remains to be fully explored and elucidated. The recent development of mouse cancer models harboring engineered mutations in Lkb1 have offered insights into how LKB1 may be functioning to restrain tumorigenesis and how its role as a master regulator of polarity and metabolism could contribute to its tumor suppressor function.

  6. LKB1 regulates lipid oxidation during exercise independently of AMPK

    DEFF Research Database (Denmark)

    Jeppesen, Jacob Fuglsbjerg; Maarbjerg, Stine Just; Jordy, Andreas Børsting

    2013-01-01

    Lipid metabolism is important for health and insulin action, yet the fundamental process of regulating lipid metabolism during muscle contraction is incompletely understood. Here, we show that LKB1 muscle-specific knockout (LKB1 MKO) mice display decreased fatty acid (FA) oxidation during treadmill...

  7. Animal Resource Program | Center for Cancer Research

    Science.gov (United States)

    CCR Animal Resource Program The CCR Animal Resource Program plans, develops, and coordinates laboratory animal resources for CCR’s research programs. We also provide training, imaging, and technology development in support of moving basic discoveries to the clinic. The ARP Manager:

  8. Draft 1992 Resource Program : Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1992-01-01

    The 1992 Resource Program will propose actions to meet future loads placed on the Bonneville Power Administration (BPA). It will also discuss and attempt to resolve resource-related policy issues. The Resource Program assesses resource availability and costs, and analyzes resource requirements and alternative ways of meeting those requirements through both conservation and generation resources. These general resource conclusions are then translated to actions for both conservation and generation. The Resource Program recommends budgets for the Office of Energy Resources for Fiscal Years (FY) 1994 and 1995. BPA`s Resource Program bears directly on an important BPA responsibility: the obligation under the Northwest Power Act{sup 3} to meet the power requirements of public and private utility and direct service industrial (DSI) customers according to their contractual agreements. BPA`s Draft 1992 Resource Program is contained in four documents: (1) 1992 Resource Program Summary; (2) Technical Report; (3) Technical Assumptions Appendix; and, (4) Conservation Implementation Plan. This volume is the Draft 1992 Resource Program Technical Report, a comprehensive document that provides supporting data and analyses for Resource Program recommendations.

  9. Draft 1992 Resource Program : Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1992-01-01

    The 1992 Resource Program will propose actions to meet future loads placed on the Bonneville Power Administration (BPA). It will also discuss and attempt to resolve resource-related policy issues. The Resource Program assesses resource availability and costs, and analyzes resource requirements and alternative ways of meeting those requirements through both conservation and generation resources. These general resource conclusions are then translated to actions for both conservation and generation. The Resource Program recommends budgets for the Office of Energy Resources for Fiscal Years (FY) 1994 and 1995. BPA's Resource Program bears directly on an important BPA responsibility: the obligation under the Northwest Power Act{sup 3} to meet the power requirements of public and private utility and direct service industrial (DSI) customers according to their contractual agreements. BPA's Draft 1992 Resource Program is contained in four documents: (1) 1992 Resource Program Summary; (2) Technical Report; (3) Technical Assumptions Appendix; and, (4) Conservation Implementation Plan. This volume is the Draft 1992 Resource Program Technical Report, a comprehensive document that provides supporting data and analyses for Resource Program recommendations.

  10. Natural resources youth training program (NRYTP), resource rangers 2010

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-09-15

    In 2010, for a second year, the natural resources youth training program (NRYTP) was developed in northern Manitoba thanks to Manitoba Keewatinowi Okimakanak Inc. (MKO) and the collaboration of 42 sponsors. 16 aboriginal youth representing six northern communities took part in the five-week program located at the Egg Lake camp. The objective was to provide these resources rangers with knowledge and training in the most widespread resource sectors in northern Manitoba, including mining, forestry and hydropower. Trainers and experts provided by industry partners offered training sessions, hands-on work experience and other activities to help resource rangers to acquire a better understanding of the employability in this field in the northern region and the knowledge and skills the resource-based careers require. Life and professional skills training was given by the camp staff and local professionals. On-site elders and cultural events also allowed the integration of a northern Cree cultural component. Three staff members, a cook and elders assisted daily the resource rangers. Many improvements and refinements have been made since the success of the 2009 program, including the involvement of a larger number of communities, program contributors and program graduates. The program length has doubled and the number of jobs created has increased, important cultural aspects were introduced and the overall expenses were reduced.

  11. A Natural Resources Management Program

    Science.gov (United States)

    Lancaster, George B.

    1977-01-01

    Three years of instruction in natural resources management (NRM) are offered at Louisa County High School, Mineral, Virginia, with 30 acres of land for use as outdoor classrooms. Instructional areas are grouped under forestry; crops and soils; and surveying, air, water, recreation, and general. Two years of basic agriculture science and mechanics…

  12. Environmental Restoration Information Resource Management Program Plan

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    The Environmental Restoration Information Resources Management (ER IRM) Program Plan defines program requirements, organizational structures and responsibilities, and work breakdown structure and to establish an approved baseline against which overall progress of the program as well as the effectiveness of its management will be measured. This plan will guide ER IRM Program execution and define the program`s essential elements. This plan will be routinely updated to incorporate key decisions and programmatic changes and will serve as the project baseline document. Environmental Restoration Waste Management Program intersite procedures and work instructions will be developed to facilitate the implementation of this plan.

  13. Probabilistic Resource Analysis by Program Transformation

    DEFF Research Database (Denmark)

    Kirkeby, Maja Hanne; Rosendahl, Mads

    2016-01-01

    The aim of a probabilistic resource analysis is to derive a probability distribution of possible resource usage for a program from a probability distribution of its input. We present an automated multi-phase rewriting based method to analyze programs written in a subset of C. It generates...... a probability distribution of the resource usage as a possibly uncomputable expression and then transforms it into a closed form expression using over-approximations. We present the technique, outline the implementation and show results from experiments with the system....

  14. Resources for Guidance Program Improvement. Volume I.

    Science.gov (United States)

    Walz, Garry R., Comp.; And Others

    Designed for use by counselors, guidance directors, school administrators, school board members, and anyone interested in the improvement of school guidance programs, this resource book provides a collection of over 100 guidance program models and individual guidance practices. The format consists of references (bibliographic information with…

  15. Random Experiment Program Resource Impact (REPRI) program: User's manual

    Science.gov (United States)

    Pease, W. T.; Alford, R. A.

    1972-01-01

    A complete user and programmer guide for the REPRI program is presented. This program was developed to perform mission concept, subsystem capability, and experiment support compatibility studies for a space station. The program utilizes Monte Carlo techniques to randomly schedule events in discrete intervals. Resources, logistics, cost, and space station volume are considered.

  16. Dynamic Programming Applications in Water Resources

    Science.gov (United States)

    Yakowitz, Sidney

    1982-08-01

    The central intention of this survey is to review dynamic programming models for water resource problems and to examine computational techniques which have been used to obtain solutions to these problems. Problem areas surveyed here include aqueduct design, irrigation system control, project development, water quality maintenance, and reservoir operations analysis. Computational considerations impose severe limitation on the scale of dynamic programming problems which can be solved. Inventive numerical techniques for implementing dynamic programming have been applied to water resource problems. Discrete dynamic programming, differential dynamic programming, state incremental dynamic programming, and Howard's policy iteration method are among the techniques reviewed. Attempts have been made to delineate the successful applications, and speculative ideas are offered toward attacking problems which have not been solved satisfactorily.

  17. LKB1/AMPK and PKA Control ABCB11 Trafficking and Polarization in Hepatocytes

    OpenAIRE

    László Homolya; Dong Fu; Prabuddha Sengupta; Michal Jarnik; Jean-Pierre Gillet; Lynn Vitale-Cross; Silvio Gutkind, J; Jennifer Lippincott-Schwartz; Arias, Irwin M.

    2014-01-01

    Polarization of hepatocytes is manifested by bile canalicular network formation and activation of LKB1 and AMPK, which control cellular energy metabolism. The bile acid, taurocholate, also regulates development of the canalicular network through activation of AMPK. In the present study, we used collagen sandwich hepatocyte cultures from control and liver-specific LKB1 knockout mice to examine the role of LKB1 in trafficking of ABCB11, the canalicular bile acid transporter. In polarized hepato...

  18. LKB1 destabilizes microtubules in myoblasts and contributes to myoblast differentiation.

    Directory of Open Access Journals (Sweden)

    Isma Mian

    Full Text Available BACKGROUND: Skeletal muscle myoblast differentiation and fusion into multinucleate myotubes is associated with dramatic cytoskeletal changes. We find that microtubules in differentiated myotubes are highly stabilized, but premature microtubule stabilization blocks differentiation. Factors responsible for microtubule destabilization in myoblasts have not been identified. FINDINGS: We find that a transient decrease in microtubule stabilization early during myoblast differentiation precedes the ultimate microtubule stabilization seen in differentiated myotubes. We report a role for the serine-threonine kinase LKB1 in both microtubule destabilization and myoblast differentiation. LKB1 overexpression reduced microtubule elongation in a Nocodazole washout assay, and LKB1 RNAi increased it, showing LKB1 destabilizes microtubule assembly in myoblasts. LKB1 levels and activity increased during myoblast differentiation, along with activation of the known LKB1 substrates AMP-activated protein kinase (AMPK and microtubule affinity regulating kinases (MARKs. LKB1 overexpression accelerated differentiation, whereas RNAi impaired it. CONCLUSIONS: Reduced microtubule stability precedes myoblast differentiation and the associated ultimate microtubule stabilization seen in myotubes. LKB1 plays a positive role in microtubule destabilization in myoblasts and in myoblast differentiation. This work suggests a model by which LKB1-induced microtubule destabilization facilitates the cytoskeletal changes required for differentiation. Transient destabilization of microtubules might be a useful strategy for enhancing and/or synchronizing myoblast differentiation.

  19. Learning Based on the Joining of Knowledge Bricks (LKB

    Directory of Open Access Journals (Sweden)

    González-Gutierrez C.A.

    2012-07-01

    Full Text Available In this paper an educational methodology called learning based on the joining of knowledge bricks (LKB is presented. Such methodology allows the students to integrate the knowledge acquired in the classroom. The integration is reached when the student interconnects the “knowledge bricks” through the “learning trajectories” under the teacher´s guidance. Finally, the proposal given in this paper is useful to be applied in engineering careers where it is necessary understand theoretical concepts.

  20. Interference with energy metabolism by 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induces HPV suppression in cervical carcinoma cells and apoptosis in the absence of LKB11

    Science.gov (United States)

    Nafz, Julia; De-Castro Arce, Johanna; Fleig, Verena; Patzelt, Andrea; Mazurek, Sybille; Rösl, Frank

    2007-01-01

    Carcinogenesis is a dynamic and stepwise process, which is accompanied by a variety of somatic and epigenetic alterations in response to a changing microenvironment. Hypoxic conditions will select for cells that have adjusted their metabolic profile and can maintain proliferation by successfully competing for scarce nutritional and oxygen resources. In the present study we have investigated the effects of energy depletion in the context of HPV (human papillomavirus)-induced pathogenesis. We show that cervical carcinoma cell lines are susceptible to undergoing either growth arrest or cell death under conditions of metabolic stress induced by AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside), a known activator of the AMPK (AMP-activated protein kinase). Our results reveal that AICAR treatment leads to a reduced binding affinity of the transcription factor AP-1 (activator protein-1) and in turn to a selective suppression of HPV transcription. Moreover, the outcome of AICAR on proliferation and survival was dependent on p53 activation and the presence of LKB1, the major upstream kinase of AMPK. Using non-malignant LKB1-expressing somatic cell hybrids, which lose expression after tumorigenic segregation, as well as small interfering RNA LKB1 knockdown approaches, we could further demonstrate that expression of LKB1 protects cells from cytotoxicity induced by agents which modulate the ATP/AMP ratio. Since simulation of low energy status can selectively eradicate LKB1-negative cervical carcinoma cells, AICAR may represent a novel drug in the treatment of cervical cancer. PMID:17212587

  1. RAOPS: Resource Allocation Optimization Program for Safegurards

    Energy Technology Data Exchange (ETDEWEB)

    Zardecki, A.; Markin, J.T.

    1994-03-01

    RAOPS--Resource Allocation Optimization Program for Safeguards is extended to a multiobjective return function having the detection probability and expected detection time as criteria. The expected detection time is included as a constraint, based on the well-known Avenhaus model of the optimum number of inventory periods. Examples of computation are provided.

  2. Education Program on Fossil Resources Including Coal

    Science.gov (United States)

    Usami, Masahiro

    Fossil fuels including coal play a key role as crucial energies in contributing to economic development in Asia. On the other hand, its limited quantity and the environmental problems causing from its usage have become a serious global issue and a countermeasure to solve such problems is very much demanded. Along with the pursuit of sustainable development, environmentally-friendly use of highly efficient fossil resources should be therefore, accompanied. Kyushu-university‧s sophisticated research through long years of accumulated experience on the fossil resources and environmental sectors together with the advanced large-scale commercial and empirical equipments will enable us to foster cooperative research and provide internship program for the future researchers. Then, this program is executed as a consignment business from the Ministry of Economy, Trade and Industry from 2007 fiscal year to 2009 fiscal year. The lecture that uses the textbooks developed by this program is scheduled to be started a course in fiscal year 2010.

  3. Lkb1 deletion promotes ectopic lipid accumulation in muscle progenitor cells and mature muscles.

    Science.gov (United States)

    Shan, Tizhong; Zhang, Pengpeng; Bi, Pengpeng; Kuang, Shihuan

    2015-05-01

    Excessive intramyocellular triglycerides (muscle lipids) are associated with reduced contractile function, insulin resistance, and Type 2 diabetes, but what governs lipid accumulation in muscle is unclear. Here we report a role of Lkb1 in regulating lipid metabolism in muscle stem cells and their descendent mature muscles. We used Myod(Cre) and Lkb1(flox/flox) mice to specifically delete Lkb1 in myogenic cells including stem and differentiated cells, and examined the lipid accumulation and gene expression of myoblasts cultured from muscle stem cells (satellite cells). Genetic deletion of Lkb1 in myogenic progenitors led to elevated expression of lipogenic genes and ectopic lipid accumulation in proliferating myoblasts. Interestingly, the Lkb1-deficient myoblasts differentiated into adipocyte-like cells upon adipogenic induction. However, these adipocyte-like cells maintained myogenic gene expression with reduced ability to form myotubes efficiently. Activation of AMPK by AICAR prevented ectopic lipid formation in the Lkb1-null myoblasts. Notably, Lkb1-deficient muscles accumulated excessive lipids in vivo in response to high-fat diet feeding. These results demonstrate that Lkb1 acts through AMPK to limit lipid deposition in muscle stem cells and their derivative mature muscles, and point to the possibility of controlling muscle lipid content using AMPK activating drugs. © 2014 Wiley Periodicals, Inc.

  4. A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress

    Directory of Open Access Journals (Sweden)

    Joan Ritho

    2015-08-01

    Full Text Available SUMOylation has been implicated in cellular stress adaptation, but its role in regulating liver kinase B1 (LKB1, a major upstream kinase of the energy sensor AMP-activated protein kinase (AMPK, is unknown. Here, we show that energy stress triggers an increase in SUMO1 modification of LKB1, despite a global reduction in both SUMO1 and SUMO2/3 conjugates. During metabolic stress, SUMO1 modification of LKB1 lysine 178 is essential in promoting its interaction with AMPK via a SUMO-interacting motif (SIM essential for AMPK activation. The LKB1 K178R SUMO mutant had defective AMPK signaling and mitochondrial function, inducing death in energy-deprived cells. These results provide additional insight into how LKB1-AMPK signaling is regulated during energy stress, and they highlight the critical role of SUMOylation in maintaining the cell’s energy equilibrium.

  5. A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress

    KAUST Repository

    Ritho, Joan

    2015-07-23

    SUMOylation has been implicated in cellular stress adaptation, but its role in regulating liver kinase B1 (LKB1), a major upstream kinase of the energy sensor AMP-activated protein kinase (AMPK), is unknown. Here, we show that energy stress triggers an increase in SUMO1 modification of LKB1, despite a global reduction in both SUMO1 and SUMO2/3 conjugates. During metabolic stress, SUMO1 modification of LKB1 lysine 178 is essential in promoting its interaction with AMPK via a SUMO-interacting motif (SIM) essential for AMPK activation. The LKB1 K178R SUMO mutant had defective AMPK signaling and mitochondrial function, inducing death in energy-deprived cells. These results provide additional insight into how LKB1-AMPK signaling is regulated during energy stress, and they highlight the critical role of SUMOylation in maintaining the cell’s energy equilibrium.

  6. 30 CFR 402.6 - Water-Resources Research Program.

    Science.gov (United States)

    2010-07-01

    ... interpreting the results of scientific and engineering research on water-resources problems. (10) Providing... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Water-Resources Research Program. 402.6 Section 402.6 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM...

  7. Advanced Reactors Transition Program Resource Loaded Schedule

    Energy Technology Data Exchange (ETDEWEB)

    GANTT, D.A.

    2000-01-12

    The Advanced Reactors Transition (ART) Resource Loaded Schedule (RLS) provides a cost and schedule baseline for managing the project elements within the ART Program. The Fast Flux Test Facility (FETF) activities are delineated through the end of FY 2000, assuming continued standby. The Nuclear Energy (NE) Legacies and Plutonium Recycle Test Reactor (PRTR) activities are delineated through the end of the deactivation process. This revision reflects the 19 Oct 1999 baseline.

  8. Advanced Reactors Transition Program Resource Loaded Schedule

    Energy Technology Data Exchange (ETDEWEB)

    BOWEN, W.W.

    1999-11-08

    The Advanced Reactors Transition (ART) Resource Loaded Schedule (RLS) provides a cost and schedule baseline for managing the project elements within the ART Program. The Fast Flux Test Facility (FFTF) activities are delineated through the end of FY 2000, assuming continued standby. The Nuclear Energy (NE) Legacies and Plutonium Recycle Test Reactor (PRTR) activities are delineated through the end of the deactivation process. This document reflects the 1 Oct 1999 baseline.

  9. Lipopolysaccharides Promote S-Nitrosylation and Proteasomal Degradation of Liver Kinase B1 (LKB1) in Macrophages in Vivo.

    Science.gov (United States)

    Liu, Zhaoyu; Dai, Xiaoyan; Zhu, Huaiping; Zhang, Miao; Zou, Ming-Hui

    2015-07-31

    LKB1 (liver kinase B1) plays important roles in tumor suppression, energy metabolism, and, recently, in innate immune responses. However, how LKB1 is regulated under physiological or pathological conditions is still unclear. Here, we report that LKB1 protein (but not mRNA) was decreased in both LPS-treated RAW 264.7 cells and peritoneal macrophages isolated from LPS-challenged mice. Additional LPS treatment promoted protein ubiquitination and degradation of LKB1. Pharmacological inhibition or gene silencing of inducible NOS abrogated LPS-induced LKB1 degradation, whereas exposure of RAW 264.7 cells to S-nitroso-l-glutathione, a NO donor, triggered LKB1 S-nitrosylation. Consistently, mutation of one cysteine (C430S) in LKB1 prevented LPS-induced S-nitrosylation, ubiquitination, and degradation. Moreover, S-nitrosylation and ubiquitination of LKB1 were confirmed in macrophages from LPS-challenged mice in vivo. Co-administration of the inducible NOS inhibitor S-methylisothiourea or the proteasome inhibitor MG132 prevented LPS-induced LKB1 degradation and improved the survival rate. Finally, mice lacking LKB1 in macrophages had significantly lower survival rates in response to LPS challenge compared with wild-type mice. Thus, we concluded that LKB1 is degraded by LPS treatment via S-nitrosylation-dependent proteasome pathways, and this had a protective role in LPS-induced septic shock. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  10. Microcomputer resource inspection/self-inspection program

    Energy Technology Data Exchange (ETDEWEB)

    Hockett, E.L. Jr.; Marlow, K.A.

    1993-03-22

    A Computer Security Program is more than just a concept. It is real action by real people. Under direction of DOE Orders, Martin Marietta Energy systems, Inc., personnel have developed a Microcomputer Security Program that is both effective and sensible. this program works because those involved have a sincere desire to protect DOE information and assets. The Oak Ridge Y-12 Plant is located in Oak Ridge, Tennessee. This facility covers 2.25 miles in the Bear Creek area and consists of approximately 500 buildings, which are located in Protected, Exclusion, and Property Protection Areas. There are some 50 different Energy Systems organizations that comprise the Y-12 Plant. There are approximately 700 classified microcomputers and approximately 5,300 unclassified microcomputers at the site. These resources are used for many different functions including: word processing, computer Aided Design operations, database management, servers for local area networks, and terminal emulators. Most microcomputers are used in a stand-alone mode of operation.

  11. LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes.

    Directory of Open Access Journals (Sweden)

    László Homolya

    Full Text Available Polarization of hepatocytes is manifested by bile canalicular network formation and activation of LKB1 and AMPK, which control cellular energy metabolism. The bile acid, taurocholate, also regulates development of the canalicular network through activation of AMPK. In the present study, we used collagen sandwich hepatocyte cultures from control and liver-specific LKB1 knockout mice to examine the role of LKB1 in trafficking of ABCB11, the canalicular bile acid transporter. In polarized hepatocytes, ABCB11 traffics from Golgi to the apical plasma membrane and endogenously cycles through the rab 11a-myosin Vb recycling endosomal system. LKB1 knockout mice were jaundiced, lost weight and manifested impaired bile canalicular formation and intracellular trafficking of ABCB11, and died within three weeks. Using live cell imaging, fluorescence recovery after photobleaching (FRAP, particle tracking, and biochemistry, we found that LKB1 activity is required for microtubule-dependent trafficking of ABCB11 to the canalicular membrane. In control hepatocytes, ABCB11 trafficking was accelerated by taurocholate and cAMP; however, in LKB1 knockout hepatocytes, ABCB11 trafficking to the apical membrane was greatly reduced and restored only by cAMP, but not taurocholate. cAMP acted through a PKA-mediated pathway which did not activate AMPK. Our studies establish a regulatory role for LKB1 in ABCB11 trafficking to the canalicular membrane, hepatocyte polarization, and canalicular network formation.

  12. NANA Wind Resource Assessment Program Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Jay Hermanson

    2010-09-23

    NANA Regional Corporation (NRC) of northwest Alaska is located in an area with abundant wind energy resources. In 2007, NRC was awarded grant DE-FG36-07GO17076 by the US Department of Energy's Tribal Energy Program for funding a Wind Resource Assessment Project (WRAP) for the NANA region. The NANA region, including Kotzebue Electric Association (KEA) and Alaska Village Electric Cooperative (AVEC) have been national leaders at developing, designing, building, and operating wind-diesel hybrid systems in Kotzebue (starting in 1996) and Selawik (2002). Promising sites for the development of new wind energy projects in the region have been identified by the WRAP, including Buckland, Deering, and the Kivalina/Red Dog Mine Port Area. Ambler, Shungnak, Kobuk, Kiana, Noorvik & Noatak were determined to have poor wind resources at sites in or very near each community. However, all five of these communities may have better wind resources atop hills or at sites with slightly higher elevations several miles away.

  13. 1992 Resource Program, 10 Year Plan : Draft II.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1992-05-01

    The Resource Program is the Bonneville Power Administration's primary process for deciding how to meet future electricity resource needs, how much new resources to develop, which types of resources to acquire or option and how to go about acquiring them, and how much BPA will have to spend for these resources. Recognizing that BPA must make a long-term commitment to acquiring conservation effectively, the 1992 Resource Program outlines a 10-year plan. Draft 2 of the 1992 Resource Program provides a framework for discussing the funding levels proposed in the Programs in Perspective (PIP) process. Previous final resource programs have been released prior to the PIP process. This version of the Resource Program recognizes that the PIP discussions are an integral part of the resource decision-making process and, therefore, it will be finalized after PIP.

  14. 1992 Resource Program, 10 Year Plan : Draft II.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1992-05-01

    The Resource Program is the Bonneville Power Administration`s primary process for deciding how to meet future electricity resource needs, how much new resources to develop, which types of resources to acquire or option and how to go about acquiring them, and how much BPA will have to spend for these resources. Recognizing that BPA must make a long-term commitment to acquiring conservation effectively, the 1992 Resource Program outlines a 10-year plan. Draft 2 of the 1992 Resource Program provides a framework for discussing the funding levels proposed in the Programs in Perspective (PIP) process. Previous final resource programs have been released prior to the PIP process. This version of the Resource Program recognizes that the PIP discussions are an integral part of the resource decision-making process and, therefore, it will be finalized after PIP.

  15. Resource Contingency Program : Draft Environmental Impact Statement.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1995-02-01

    In 1990, the Bonneville Power Administration (BPA) embarked upon the Resource Contingency Program (RCP) to fulfill its statutory responsibilities to supply electrical power to its utility, industrial and other customers in the Pacific Northwest. Instead of buying or building generating plants now, BPA has purchased options to acquire power later if needed. Three option development agreements were signed in September 1993 with three proposed natural gas-fired, combined cycle combustion turbine CT projects near Chehalis and Satsop Washington and near Hermiston, Oregon. This environmental impact statement addresses the environmental consequences of purchasing power from these options. This environmental impact statement addresses the environmental consequences of purchasing power from these options.

  16. Energy sensing and cancer: LKB1 function and lessons learnt from Peutz-Jeghers syndrome.

    Science.gov (United States)

    Shorning, Boris Y; Clarke, Alan R

    2016-04-01

    We describe in this review increasing evidence that loss of LKB1 kinase in Peutz-Jeghers syndrome (PJS) derails the existing natural balance between cell survival and tumour growth suppression. LKB1 deletion can plunge cells into an energy/oxidative stress-induced crisis which leads to the activation of alternative and often carcinogenic pathways to maintain cellular energy levels. It therefore appears that although LKB1 deficiency can suppress oncogenic transformation in the short term, it can ultimately lead to more progressed and malignant phenotypes by driving abnormal cell differentiation, genomic instability and increased tumour heterogeneity. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. The LKB1 tumor suppressor differentially affects anchorage independent growth of HPV positive cervical cancer cell lines

    Energy Technology Data Exchange (ETDEWEB)

    Mack, Hildegard I.D.; Munger, Karl, E-mail: kmunger@rics.bwh.harvard.edu

    2013-11-15

    Infection with high-risk human papillomaviruses is causally linked to cervical carcinogenesis. However, most lesions caused by high-risk HPV infections do not progress to cancer. Host cell mutations contribute to malignant progression but the molecular nature of such mutations is unknown. Based on a previous study that reported an association between liver kinase B1 (LKB1) tumor suppressor loss and poor outcome in cervical cancer, we sought to determine the molecular basis for this observation. LKB1-negative cervical and lung cancer cells were reconstituted with wild type or kinase defective LKB1 mutants and we examined the importance of LKB1 catalytic activity in known LKB1-regulated processes including inhibition of cell proliferation and elevated resistance to energy stress. Our studies revealed marked differences in the biological activities of two kinase defective LKB1 mutants in the various cell lines. Thus, our results suggest that LKB1 may be a cell-type specific tumor suppressor. - Highlights: • LKB1 is a tumor suppressor that is linked to Peutz-Jeghers syndrome. • Peutz-Jeghers syndrome patients have a high incidence of cervical cancer. • Cervical cancer is caused by HPV infections. • This study investigates LKB1 tumor suppressor activity in cervical cancer.

  18. The Prognostic Value of Decreased LKB1 in Solid Tumors: A Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Jian Xiao

    Full Text Available Liver kinase B1 (LKB1 is a protein kinase that regulates the growth, integrity and polarity of mammalian cells. Recent studies have reported the prognostic value of decreased LKB1 expression in different tumors. However, the results of these studies remain controversial. Therefore, this meta-analysis was performed to more accurately estimate the role of decreased LKB1 in the prognostication of human solid tumors.A systematic literature search in the electronic databases PubMed, Embase, Web of Science and CNKI (updated to October 15, 2015 was performed to identify eligible studies. The overall survival (OS, relapse-free survival (RFS, disease-free survival (DFS and clinicopathological features data were collected from these studies. The hazard ratios (HRs, odds ratios (ORs and 95% confidence intervals (CIs were calculated and pooled with a random-effects models using Stata12.0 software.A total of 14 studies covering 1915 patients with solid tumors were included in this meta-analysis. Decreased LKB1 was associated with poorer OS in both the univariate (HR: 1.86, 95%CI: 1.42-2.42, P<0.001 and multivariate (HR: 1.55, 95%CI: 1.09-2.21, P = 0.015 analyses. A subgroup analysis revealed that the associations between decreased LKB1 and poor OS were significant within the Asian region (HR 2.18, 95%CI: 1.66-2.86, P<0.001 and obvious for lung cancer (HR: 2.16, 95%CI: 1.47-3.18, P<0.001. However, the articles that involved analyses of both RFS and DFS numbered only 3, and no statistically significant correlations of decreased LKB1 with RFS or DFS were observed in this study. Additionally, the pooled odds ratios (ORs indicated that decreased LKB1 was associated with larger tumor size (OR: 1.60, 95%CI: 1.09-2.36, P = 0.017, lymph node metastasis (OR: 2.41, 95%CI: 1.53-3.78, P<0.001 and a higher TNM stage (OR: 3.35, 95%CI: 2.20-5.09, P<0.001.These results suggest that decreased LKB1 expression in patients with solid tumors might be related to poor prognosis and

  19. Convergence of IPMK and LKB1-AMPK signaling pathways on metformin action.

    Science.gov (United States)

    Bang, Sookhee; Chen, Yong; Ahima, Rexford S; Kim, Sangwon F

    2014-07-01

    Metformin is a biguanide drug that is widely prescribed for type 2 diabetes. Metformin suppresses hepatic gluconeogenesis and increases fatty acid oxidation. Although studies have suggested that metformin acts, at least in part, via activation of the liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) pathway, the specific molecular mechanisms underlying metformin's regulation of glucose and lipid metabolism have not been well delineated. Recently, we have shown that inositol polyphosphate multikinase (IPMK) plays an important role in cellular energy metabolism and glucose-mediated AMPK regulation. Here we investigated the role of IPMK in metformin-induced AMPK activation. We observed that metformin-mediated activation of AMPK was impaired in the absence of IPMK. Overexpression of wild-type IPMK was sufficient to restore LKB1-AMPK activation by either metformin or AICAR in IPMK(-/-) murine embryonic fibroblast cells, suggesting that IPMK may act as an upstream regulator of LKB1-AMPK signaling in response to metformin. Moreover, this regulation was mediated by protein-protein interaction between IPMK and LKB1 as a dominant-negative peptide, which abrogates this interaction, attenuated metformin's ability to activate AMPK. Our data demonstrate that IPMK plays an important role in LKB1/AMPK signaling and may be targeted for treatment of metabolic diseases.

  20. Program review: resource evaluation, reservoir confirmation, and exploration technology

    Energy Technology Data Exchange (ETDEWEB)

    Ward, S.H.

    1978-05-01

    The details of the program review are reported. A summary of the recommendations, means for their implementation, and a six year program of expenditures which would accomplish the objectives of the recommendations are presented. Included in appendices are the following: DOE/DGE consortia participants; program managers contacted for opinion; communications received from program managers; participants, program review panel; and program strategy for resource evaluation and reservoir confirmation. (MHR)

  1. Resource Programs : Draft Environmental Impact Statement, Volume 2, Appendices.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1992-03-01

    Every two years, Bonneville Power Administration (BPA) prepares a Resource Program which identifies the resource actions BPA will take to meet its obligation to serve the forecasted power requirements of its customers. The Resource Program`s Environmental Impact Statement (RPEIS) is a programmatic environmental document which will support decisions made in several future Resource Programs. Environmental documents tiered to the EIS may be prepared on a site-specific basis. The RPEIS includes a description of the environmental effects and mitigation for the various resource types available in order to evaluate the trade-offs among them. It also assesses the environmental impacts of adding thirteen alternative combinations of resources to the existing power system. This report contains the appendices to the RPEIS.

  2. Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1

    DEFF Research Database (Denmark)

    Bai, Bo; Man, Andy W C; Yang, Kangmin

    2016-01-01

    Aims-SIRT1 exerts potent activity against cellular senescence and vascular ageing. By decreasing LKB1 protein levels, it promotes the survival and regeneration of endothelial cells. The present study aims to investigate the molecular mechanisms underlying SIRT1-mediated LKB1 degradation for the p...

  3. The NIH Roadmap Epigenomics Program data resource.

    Science.gov (United States)

    Chadwick, Lisa Helbling

    2012-06-01

    The NIH Roadmap Reference Epigenome Mapping Consortium is developing a community resource of genome-wide epigenetic maps in a broad range of human primary cells and tissues. There are large amounts of data already available, and a number of different options for viewing and analyzing the data. This report will describe key features of the websites where users will find data, protocols and analysis tools developed by the consortium, and provide a perspective on how this unique resource will facilitate and inform human disease research, both immediately and in the future.

  4. Natural Resources and Forest Ecology. Florida Vocational Program Guide.

    Science.gov (United States)

    Florida State Univ., Tallahassee. Center for Instructional Development and Services.

    This program guide identifies primary considerations in the organization, operation, and evaluation of a natural resources and forest ecology program. Program content is presented first. A curriculum framework specifies the exact course title, course number, levels of instruction, major course content, laboratory activities, special notes, major…

  5. FASP, an analytic resource appraisal program for petroleum play analysis

    Science.gov (United States)

    Crovelli, R.A.; Balay, R.H.

    1986-01-01

    An analytic probabilistic methodology for resource appraisal of undiscovered oil and gas resources in play analysis is presented in a FORTRAN program termed FASP. This play-analysis methodology is a geostochastic system for petroleum resource appraisal in explored as well as frontier areas. An established geologic model considers both the uncertainty of the presence of the assessed hydrocarbon and its amount if present. The program FASP produces resource estimates of crude oil, nonassociated gas, dissolved gas, and gas for a geologic play in terms of probability distributions. The analytic method is based upon conditional probability theory and many laws of expectation and variance. ?? 1986.

  6. Measurement and Analysis of P2P IPTV Program Resource

    Directory of Open Access Journals (Sweden)

    Wenxian Wang

    2014-01-01

    Full Text Available With the rapid development of P2P technology, P2P IPTV applications have received more and more attention. And program resource distribution is very important to P2P IPTV applications. In order to collect IPTV program resources, a distributed multi-protocol crawler is proposed. And the crawler has collected more than 13 million pieces of information of IPTV programs from 2009 to 2012. In addition, the distribution of IPTV programs is independent and incompact, resulting in chaos of program names, which obstructs searching and organizing programs. Thus, we focus on characteristic analysis of program resources, including the distributions of length of program names, the entropy of the character types, and hierarchy depth of programs. These analyses reveal the disorderly naming conventions of P2P IPTV programs. The analysis results can help to purify and extract useful information from chaotic names for better retrieval and accelerate automatic sorting of program and establishment of IPTV repository. In order to represent popularity of programs and to predict user behavior and popularity of hot programs over a period, we also put forward an analytical model of hot programs.

  7. Federal Smart Cities and Communities Programs Resource Guide

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — The Federal Smart Cities and Communities Task Force created the " Federal Smart Cities and Communities Programs Resource Guide " to facilitate collaboration and...

  8. Time Aquatic Resources Modeling and Analysis Program (STARMAP)

    Data.gov (United States)

    Federal Laboratory Consortium — Colorado State University has received funding from the U.S. Environmental Protection Agency (EPA) for its Space-Time Aquatic Resources Modeling and Analysis Program...

  9. LKB1 Is Required for the Development and Maintenance of Stereocilia in Inner Ear Hair Cells in Mice.

    Directory of Open Access Journals (Sweden)

    Yuqin Men

    Full Text Available The LKB1 gene, which encodes a serine/threonine kinase, was discovered to play crucial roles in cell differentiation, proliferation, and the establishment of cell polarity. In our study, LKB1 conditional knockout mice (Atoh1-LKB1-/- mice were generated to investigate LKB1 function in the inner ear. Tests of auditory brainstem response and distortion product otoacoustic emissions revealed significant decreases in the hearing sensitivities of the Atoh1-LKB1-/- mice. In Atoh1-LKB1-/- mice, malformations of hair cell stereocilliary bundles were present as early as postnatal day 1 (P1, a time long before the maturation of the hair cell bundles. In addition, we also observed outer hair cell (OHC loss starting at P14. The impaired stereocilliary bundles occurred long before the presence of hair cell loss. Stereociliary cytoskeletal structure depends on the core actin-based cytoskeleton and several actin-binding proteins. By Western blot, we examined actin-binding proteins, specifically ERM (ezrin/radixin/moesin proteins involved in the regulation of the actin cytoskeleton of hair cell stereocilia. Our results revealed that the phosphorylation of ERM proteins (pERM was significantly decreased in mutant mice. Thus, we propose that the decreased pERM may be a key factor for the impaired stereocillia function, and the damaged stereocillia may induce hair cell loss and hearing impairments. Taken together, our data indicates that LKB1 is required for the development and maintenance of stereocilia in the inner ear.

  10. LKB1 mediates the development of conventional and innate T cells via AMP-dependent kinase autonomous pathways.

    Directory of Open Access Journals (Sweden)

    Marouan Zarrouk

    Full Text Available The present study has examined the role of the serine/threonine kinase LKB1 in the survival and differentiation of CD4/8 double positive thymocytes. LKB1-null DPs can respond to signals from the mature α/β T-cell-antigen receptor and initiate positive selection. However, in the absence of LKB1, thymocytes fail to mature to conventional single positive cells causing severe lymphopenia in the peripheral lymphoid tissues. LKB1 thus appears to be dispensable for positive selection but important for the maturation of positively selected thymocytes. LKB1 also strikingly prevented the development of invariant Vα14 NKT cells and innate TCR αβ gut lymphocytes. Previous studies with gain of function mutants have suggested that the role of LKB1 in T cell development is mediated by its substrate the AMP-activated protein kinase (AMPK. The present study now analyses the impact of AMPK deletion in DP thymocytes and shows that the role of LKB1 during the development of both conventional and innate T cells is mediated by AMPK-independent pathways.

  11. Sexuality Education Programs for Parents: Bibliography of Selected Resources.

    Science.gov (United States)

    Planned Parenthood Federation of America, Inc., New York, NY. Education Dept.

    This bibliography of selected resources was compiled to provide valuable information for persons involved in planning parent programs in sexuality education. Names and addresses of three sources for additional information and resources are also provided. Citations in the bibliography are organized under Books and Related Materials (38 references)…

  12. Women and Nontraditional Programs: A Compendium of Resources.

    Science.gov (United States)

    Eveslage, Sonja A.

    1979-01-01

    A wide range of resource material is available which explores various aspects of the problem of sex-role stereotyping. Much of this literature has applications in attracting women into nontraditional vocational-technical education programs. Readings are recommended concerning sexism in education, administrator resources, counseling material, and…

  13. Otolaryngology Residency Program Research Resources and Scholarly Productivity.

    Science.gov (United States)

    Villwock, Jennifer A; Hamill, Chelsea S; Nicholas, Brian D; Ryan, Jesse T

    2017-06-01

    Objective To delineate research resources available to otolaryngology residents and their impact on scholarly productivity. Study Design Survey of current otolaryngology program directors. Setting Otolaryngology residency programs. Subjects and Methods An anonymous web-based survey was sent to 98 allopathic otolaryngology training program directors. Fisher exact tests and nonparametric correlations were used to determine statistically significant differences among various strata of programs. Results Thirty-nine percent (n = 38) of queried programs responded. Fourteen (37%) programs had 11 to 15 full-time, academic faculty associated with the residency program. Twenty (53%) programs have a dedicated research coordinator. Basic science lab space and financial resources for statistical work were present at 22 programs (58%). Funding is uniformly provided for presentation of research at conferences; a minority of programs (13%) only funded podium presentations. Twenty-four (63%) have resident research requirements beyond the Accreditation Council for Graduate Medical Education (ACGME) mandate of preparing a "manuscript suitable for publication" prior to graduation. Twenty-five (67%) programs have residents with 2 to 3 active research projects at any given time. None of the investigated resources were significantly associated with increased scholarly output. There was no uniformity to research curricula. Conclusions Otolaryngology residency programs value research, evidenced by financial support provided and requirements beyond the ACGME minimum. Additional resources were not statistically related to an increase in resident research productivity, although they may contribute positively to the overall research experience during training. Potential future areas to examine include research curricula best practices, how to develop meaningful mentorship and resource allocation that inspires continued research interest, and intellectual stimulation.

  14. 30 CFR 402.7 - Water-Resources Technology Development Program.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Water-Resources Technology Development Program. 402.7 Section 402.7 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources...

  15. The U.S. Geological Survey Energy Resources Program

    Science.gov (United States)

    ,

    2006-01-01

    The United States uses tremendous amounts of geologic energy resources. In 2004 alone, the United States consumed more than 7.4 billion barrels of oil, 21.9 trillion cubic feet of natural gas, and 1.1 billion short tons of coal. Forecasts indicate the Nation's need for energy resources will continue to grow, raising several questions: How much domestic and foreign petroleum resources are available to meet the growing energy demands of the Nation and world? Does the United States have coal deposits of sufficient quantity and quality to meet demand over the next century? What other geologic energy resources can be added to the U.S. energy mix? How do the occurrence and use of energy resources affect environmental quality and human health? Unbiased information from robust scientific studies is needed for sound energy policy and resource management decisions addressing these issues. The U.S. Geological Survey Energy Resources Program provides impartial, scientifically robust information to advance the understanding of geologically based energy resources including: petroleum (oil, natural gas, natural gas liquids), coal, gas hydrates, geothermal resources, oil shale, oil sands, uranium, and heavy oil and natural bitumen. This information can be used to contribute to plans for a secure energy future and to facilitate evaluation and responsible use of resources.

  16. INEEL Cultural Resource Management Program Annual Report - 2004

    Energy Technology Data Exchange (ETDEWEB)

    Clayton F. Marler

    2005-01-01

    As a federal agency, the U.S. Department of Energy has been directed by Congress, the U.S. president, and the American public to provide leadership in the preservation of prehistoric, historic, and other cultural resources on the lands it administers. This mandate to preserve cultural resources in a spirit of stewardship for the future is outlined in various federal preservation laws, regulations, and guidelines such as the National Historic Preservation Act, the Archaeological Resources Protection Act, and the National Environmental Policy Act. The Idaho National Engineering and Environmental Laboratory Site is located in southeastern Idaho, and is home to vast numbers and a wide variety of important cultural resources representing at least 13,000-year span of human occupation in the region. These resources are nonrenewable, bear valuable physical and intangible legacies, and yield important information about the past, present, and perhaps the future. There are special challenges associated with balancing the preservation of these resources with the management and ongoing operation of an active scientific laboratory, while also cleaning up the waste left by past programs and processes. The Department of Energy Idaho Operations Office has administrative responsibility for most of the Site, excluding lands and resources managed by the Naval Reactors Facility and (in 2004) Argonne National Laboratory-West. The Department of Energy is committed to a cultural resource program that accepts these challenges in a manner reflecting both the spirit and intent of the legislative requirements. This annual report is an overview of Cultural Resource Management Program activities conducted during Fiscal Year 2004 and is intended to be both informative to external stakeholders and to serve as a planning tool for future cultural resource management work to be conducted on the Site.

  17. ATP and MO25? Regulate the Conformational State of the STRAD? Pseudokinase and Activation of the LKB1 Tumour Suppressor

    OpenAIRE

    Zeqiraj, Elton; Filippi, Beatrice Maria; Goldie, Simon; Navratilova, Iva; Boudeau, J?r?me; Deak, Maria; Alessi, Dario R.; van Aalten, Daan M. F.

    2009-01-01

    Pseudokinases lack essential residues for kinase activity, yet are emerging as important regulators of signal transduction networks. The pseudokinase STRAD activates the LKB1 tumour suppressor by forming a heterotrimeric complex with LKB1 and the scaffolding protein MO25. Here, we describe the structure of STRADalpha in complex with MO25alpha. The structure reveals an intricate web of interactions between STRADalpha and MO25alpha involving the alphaC-helix of STRADalpha, reminiscent of the me...

  18. Nation-Building Modeling and Resource Allocation Via Dynamic Programming

    Science.gov (United States)

    2014-09-01

    provides the ability to inform strategic resource alloca- tion decisions during ongoing nation– building operations. Historical examples may be modeled and...against moving to a peaceful state. 5.3 Model Including Violence Since enemy action information is not readily obtainable in nation– building oper...NATION– BUILDING MODELING AND RESOURCE ALLOCATION VIA DYNAMIC PROGRAMMING DISSERTATION Cade M. Saie, Major, USA AFIT–DS–ENS–14–S–18 DEPARTMENT OF THE

  19. NASA'S Water Resources Element Within the Applied Sciences Program

    Science.gov (United States)

    Toll, David; Doorn, Bradley; Engman, Edwin

    2011-01-01

    The NASA Earth Systems Division has the primary responsibility for the Applied Science Program and the objective to accelerate the use of NASA science results in applications to help solve problems important to society and the economy. The primary goal of the NASA Applied Science Program is to improve future and current operational systems by infusing them with scientific knowledge of the Earth system gained through space-based observation, assimilation of new observations, and development and deployment of enabling technologies, systems, and capabilities. This paper discusses major problems facing water resources managers, including having timely and accurate data to drive their decision support tools. It then describes how NASA's science and space based satellites may be used to overcome this problem. Opportunities for the water resources community to participate in NASA's Water Resources Applications Program are described.

  20. The U.S.Geological Survey Energy Resources Program

    Science.gov (United States)

    ,

    2010-01-01

    Energy resources are an essential component of modern society. Adequate, reliable, and affordable energy supplies obtained using environmentally sustainable practices underpin economic prosperity, environmental quality and human health, and political stability. National and global demands for all forms of energy are forecast to increase significantly over the next several decades. Throughout its history, our Nation has faced important, often controversial, decisions regarding the competing uses of public lands, the supply of energy to sustain development and enable growth, and environmental stewardship. The U.S. Geological Survey (USGS) Energy Resources Program (ERP) provides information to address these challenges by supporting scientific investigations of energy resources, such as research on the geology, geochemistry, and geophysics of oil, gas, coal, heavy oil and natural bitumen, oil shale, uranium, and geothermal resources, emerging resources such as gas hydrates, and research on the effects associated with energy resource occurrence, production, and (or) utilization. The results from these investigations provide impartial, robust scientific information about energy resources and support the U.S. Department of the Interior's (DOI's) mission of protecting and responsibly managing the Nation's natural resources. Primary consumers of ERP information and products include the DOI land- and resource-management Bureaus; other Federal, State, and local agencies; the U.S. Congress and the Administration; nongovernmental organizations; the energy industry; academia; international organizations; and the general public.

  1. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

    Science.gov (United States)

    Foretz, Marc; Hébrard, Sophie; Leclerc, Jocelyne; Zarrinpashneh, Elham; Soty, Maud; Mithieux, Gilles; Sakamoto, Kei; Andreelli, Fabrizio; Viollet, Benoit

    2010-01-01

    Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the action of metformin on hepatic gluconeogenesis. However, the molecular mechanism by which this pathway operates had remained elusive. Surprisingly, here we have found that in mice lacking AMPK in the liver, blood glucose levels were comparable to those in wild-type mice, and the hypoglycemic effect of metformin was maintained. Hepatocytes lacking AMPK displayed normal glucose production and gluconeogenic gene expression compared with wild-type hepatocytes. In contrast, gluconeogenesis was upregulated in LKB1-deficient hepatocytes. Metformin decreased expression of the gene encoding the catalytic subunit of glucose-6-phosphatase (G6Pase), while cytosolic phosphoenolpyruvate carboxykinase (Pepck) gene expression was unaffected in wild-type, AMPK-deficient, and LKB1-deficient hepatocytes. Surprisingly, metformin-induced inhibition of glucose production was amplified in both AMPK- and LKB1-deficient compared with wild-type hepatocytes. This inhibition correlated in a dose-dependent manner with a reduction in intracellular ATP content, which is crucial for glucose production. Moreover, metformin-induced inhibition of glucose production was preserved under forced expression of gluconeogenic genes through PPARγ coactivator 1α (PGC-1α) overexpression, indicating that metformin suppresses gluconeogenesis via a transcription-independent process. In conclusion, we demonstrate that metformin inhibits hepatic gluconeogenesis in an LKB1- and AMPK-independent manner via a decrease in hepatic energy state. PMID:20577053

  2. Phosphatidylinositol Ether Lipid Analogues Induce AMP-Activated Protein Kinase–Dependent Death in LKB1-Mutant Non–Small Cell Lung Cancer Cells

    Science.gov (United States)

    Memmott, Regan M.; Gills, Joell J.; Hollingshead, Melinda; Powers, Margaret C.; Chen, Zhiping; Kemp, Bruce; Kozikowski, Alan; Dennis, Phillip A.

    2013-01-01

    Loss of function of the tumor suppressor LKB1 occurs in 30% to 50% of lung adenocarcinomas. Because LKB1 activates AMP-activated protein kinase (AMPK), which can negatively regulate mTOR, AMPK activation might be desirable for cancer therapy. However, no known compounds activate AMPK independently of LKB1 in vivo, and the usefulness of activating AMPK in LKB1-mutant cancers is unknown. Here, we show that lipid-based Akt inhibitors, phosphatidylinositol ether lipid analogues (PIA), activate AMPK independently of LKB1. PIAs activated AMPK in LKB1-mutant non–small cell lung cancer (NSCLC) cell lines with similar concentration dependence as that required to inhibit Akt. However, AMPK activation was independent of Akt inhibition. AMPK activation was a major mechanism of mTOR inhibition. To assess whether another kinase capable of activating AMPK, CaMKKβ, contributed to PIA-induced AMPK activation, we used an inhibitor of CaMKK, STO-609. STO-609 inhibited PIA-induced AMPK activation in LKB1-mutant NSCLC cells, and delayed AMPK activation in wild-type LKB1 NSCLC cells. In addition, AMPK activation was not observed in NSCLC cells with mutant CaMKKβ, suggesting that CaMKKβ contributes to PIA-induced AMPK activation in cells. AMPK activation promoted PIA-induced cytotoxicity because PIAs were less cytotoxic in AMPKα−/− murine embryonic fibroblasts or LKB1-mutant NSCLC cells transfected with mutant AMPK. This mechanism was also relevant in vivo. Treatment of LKB1-mutant NSCLC xenografts with PIA decreased tumor volume by ∼50% and activated AMPK. These studies show that PIAs recapitulate the activity of two tumor suppressors (PTEN and LKB1) that converge on mTOR. Moreover, they suggest that PIAs might have utility in the treatment of LKB1-mutant lung adenocarcinomas. PMID:18199555

  3. Resources

    Science.gov (United States)

    ... disease - resources Hemophilia - resources Herpes - resources Incest - resources Incontinence - resources Infertility - resources Interstitial cystitis - resources Kidney disease - resources Leukemia - resources Liver disease - resources Loss ...

  4. Resource-agnostic programming for many-core microgrids

    NARCIS (Netherlands)

    Bernard, T.A.M.; Grelck, C.; Hicks, M.A.; Jesshope, C.R.; Poss, R.; Forsell, M.; Träff, J.L.

    2010-01-01

    Many-core architectures are a commercial reality, but programming them efficiently is still a challenge, especially if the mix is heterogeneous. Here granularity must be addressed, i.e. when to make use of concurrency resources and when not to. We have designed a data-driven, fine-grained concurrent

  5. A Public Education Program in Water Resources Management.

    Science.gov (United States)

    Amend, John R.; Armold, Anita A.

    1983-01-01

    Describes a program designed to improve public awareness/understanding of major factors in managing water resources. Use is made of an interactive computer simulator to place lay people and teachers in decision-making situations involving real variables and alternatives and to project for them the probable consequences of their water management…

  6. Key Resources for Community College Student Success Programming

    Science.gov (United States)

    Carales, Vincent D.; Garcia, Crystal E.; Mardock-Uman, Naomi

    2016-01-01

    This chapter provides an overview of organizations and other entities focused on assisting community college staff, faculty, and administrators in developing and promoting student success outcomes. We provide a listing of relevant web resources related to programming and conclude with a summary of suggested readings.

  7. Puerto Rico water resources planning model program description

    Science.gov (United States)

    Moody, D.W.; Maddock, Thomas; Karlinger, M.R.; Lloyd, J.J.

    1973-01-01

    Because the use of the Mathematical Programming System -Extended (MPSX) to solve large linear and mixed integer programs requires the preparation of many input data cards, a matrix generator program to produce the MPSX input data from a much more limited set of data may expedite the use of the mixed integer programming optimization technique. The Model Definition and Control Program (MODCQP) is intended to assist a planner in preparing MPSX input data for the Puerto Rico Water Resources Planning Model. The model utilizes a mixed-integer mathematical program to identify a minimum present cost set of water resources projects (diversions, reservoirs, ground-water fields, desalinization plants, water treatment plants, and inter-basin transfers of water) which will meet a set of future water demands and to determine their sequence of construction. While MODCOP was specifically written to generate MPSX input data for the planning model described in this report, the program can be easily modified to reflect changes in the model's mathematical structure.

  8. Human Resources Policy. Case Study: Continuing Education Programs

    Directory of Open Access Journals (Sweden)

    Cătălin BABA

    2002-06-01

    Full Text Available Life-long education programs are rather new in Romania, and there is much confusion about their structure, meaning, purposes and usefulness; although there is a clear necessity for these kinds of programs, they were implemented in our country only after recommendations were made by the European institutions. The Babeş-Bolyai University is one of the first and few Romanian universities that actually develop continuing education programs, directed at public services for the use of the local community. In this paper we present a particular case, the Program of Continuous Learning – Defense and Security Studies, designed to assist the 4th Territorial Army Corps based in Cluj-Napoca in its efforts to meet NATO standards. The program offers courses for military personnel in fields like strategic management, decision making processes, human resources management, and, of course, European security, and represents the first project of cooperation between a university and the Romanian army.

  9. NASA'S Water Resources Element Within the Applied Sciences Program

    Science.gov (United States)

    Toll, David; Doorn, Bradley; Engman, Edwin

    2010-01-01

    The NASA Applied Sciences Program works within NASA Earth sciences to leverage investment of satellite and information systems to increase the benefits to society through the widest practical use of NASA research results. Such observations provide a huge volume of valuable data in both near-real-time and extended back nearly 50 years about the Earth's land surface conditions such as land cover type, vegetation type and health, precipitation, snow, soil moisture, and water levels and radiation. Observations of this type combined with models and analysis enable satellite-based assessment of numerous water resources management activities. The primary goal of the Earth Science Applied Science Program is to improve future and current operational systems by infusing them with scientific knowledge of the Earth system gained through space-based observation, model results, and development and deployment of enabling technologies, systems, and capabilities. Water resources is one of eight elements in the Applied Sciences Program and it addresses concerns and decision making related to water quantity and water quality. With increasing population pressure and water usage coupled with climate variability and change, water issues are being reported by numerous groups as the most critical environmental problems facing us in the 21st century. Competitive uses and the prevalence of river basins and aquifers that extend across boundaries engender political tensions between communities, stakeholders and countries. Mitigating these conflicts and meeting water demands requires using existing resources more efficiently. The potential crises and conflicts arise when water is competed among multiple uses. For example, urban areas, environmental and recreational uses, agriculture, and energy production compete for scarce resources, not only in the Western U.S. but throughout much of the U.S. but also in many parts of the world. In addition to water availability issues, water quality related

  10. The 1980-1982 Geothermal Resource Assessment Program in Washington

    Energy Technology Data Exchange (ETDEWEB)

    Korosec, Michael A.; Phillips, William M.; Schuster, J.Eric

    1983-08-01

    Since 1978, the Division of Geology and Earth Resources of the Washington Department of Natural Resources has participated in the U.S. Department of Energy's (USDOE) State-Coupled Geothermal Resource Program. Federal and state funds have been used to investigate and evaluate the potential for geothermal resources, on both a reconnaissance and area-specific level. Preliminary results and progress reports for the period up through mid-1980 have already been released as a Division Open File Report (Korosec, Schuster, and others, 1981). Preliminary results and progress summaries of work carried out from mid-1980 through the end of 1982 are presented in this report. Only one other summary report dealing with geothermal resource investigations in the state has been published. An Information Circular released by the Division (Schuster and others, 1978) compiled the geology, geochemistry, and heat flow drilling results from a project in the Indian Heaven area in the south Cascades. The previous progress report for the geothermal program (Korosec, Schuster, and others, 1981) included information on temperature gradients measured throughout the state, heat flow drilling in the southern Cascades, gravity surveys for the southern Cascades, thermal and mineral spring investigations, geologic mapping for the White Pass-Tumac Mountain area, and area specific studies for the Camas area of Clark County and Mount St. Helens. This work, along with some additional studies, led to the compilation of the Geothermal Resources of Washington map (Korosec, Kaler, and others, 1981). The map is principally a nontechnical presentation based on all available geothermal information, presented as data points, tables, and text on a map with a scale of 1:500,000.

  11. Learning on human resources management in the radiology residency program

    Directory of Open Access Journals (Sweden)

    Aparecido Ferreira de Oliveira

    2014-04-01

    Full Text Available Objective To investigate the process of learning on human resource management in the radiology residency program at Escola Paulista de Medicina – Universidade Federal de São Paulo, aiming at improving radiologists' education. Materials and Methods Exploratory study with a quantitative and qualitative approach developed with the faculty staff, preceptors and residents of the program, utilizing a Likert questionnaire (46, taped interviews (18, and categorization based on thematic analysis. Results According to 71% of the participants, residents have clarity about their role in the development of their activities, and 48% said that residents have no opportunity to learn how to manage their work in a multidisciplinary team. Conclusion Isolation at medical records room, little interactivity between sectors with diversified and fixed activities, absence of a previous culture and lack of a training program on human resources management may interfere in the development of skills for the residents' practice. There is a need to review objectives of the medical residency in the field of radiology, incorporating, whenever possible, the commitment to the training of skills related to human resources management thus widening the scope of abilities of the future radiologists.

  12. Learning on human resources management in the radiology residency program

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Aparecido Ferreira de; Lederman, Henrique Manoel; Batista, Nildo Alves, E-mail: aparecidoliveira@ig.com.br [Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP (Brazil). Escola Paulista de Medicina

    2014-03-15

    Objective: to investigate the process of learning on human resource management in the radiology residency program at Escola Paulista de Medicina - Universidade Federal de Sao Paulo, aiming at improving radiologists' education. Materials and methods: exploratory study with a quantitative and qualitative approach developed with the faculty staff, preceptors and residents of the program, utilizing a Likert questionnaire (46), taped interviews (18), and categorization based on thematic analysis. Results: According to 71% of the participants, residents have clarity about their role in the development of their activities, and 48% said that residents have no opportunity to learn how to manage their work in a multidisciplinary team. Conclusion: Isolation at medical records room, little interactivity between sectors with diversified and fixed activities, absence of a previous culture and lack of a training program on human resources management may interfere in the development of skills for the residents' practice. There is a need to review objectives of the medical residency in the field of radiology, incorporating, whenever possible, the commitment to the training of skills related to human resources management thus widening the scope of abilities of the future radiologists. (author)

  13. Resource guide to occupant protection programs and materials.

    Science.gov (United States)

    Hollenbach, K; Sleet, D A

    1984-01-01

    This article lists public and private sector associations and organizations concerned with occupant protection. Many of these organizations will provide catalogues and other public information materials on occupant protection. Some have operational programs designed to influence their members in the health professions or the general public. All of the organizations have printed material available. Some provide additional resources on occupant protection such as educational kits, consumer information pamphlets, posters, written testimony, public service announcements, sample legislation, and audio visual aids useful in conjunction with health promotion program development. For information relative to state occupant protection programs, readers should contact their State Office of Highway (Traffic) Safety, Governor's Office, Regional Office of the National Highway Safety Administration, Regional Office of the Department of Health and Human Services, State Health Department or Department of Preventive Health Services, and regional or state affiliate chapters of national organizations, such as the Child Passenger Safety Associations and the National Safety Councils.

  14. Remote sensing programs and courses in engineering and water resources

    Science.gov (United States)

    Kiefer, R. W.

    1981-01-01

    The content of typical basic and advanced remote sensing and image interpretation courses are described and typical remote sensing graduate programs of study in civil engineering and in interdisciplinary environmental remote sensing and water resources management programs are outlined. Ideally, graduate programs with an emphasis on remote sensing and image interpretation should be built around a core of five courses: (1) a basic course in fundamentals of remote sensing upon which the more specialized advanced remote sensing courses can build; (2) a course dealing with visual image interpretation; (3) a course dealing with quantitative (computer-based) image interpretation; (4) a basic photogrammetry course; and (5) a basic surveying course. These five courses comprise up to one-half of the course work required for the M.S. degree. The nature of other course work and thesis requirements vary greatly, depending on the department in which the degree is being awarded.

  15. CoalVal-A coal resource valuation program

    Science.gov (United States)

    Rohrbacher, Timothy J.; McIntosh, Gary E.

    2010-01-01

    CoalVal is a menu-driven Windows program that produces cost-of-mining analyses of mine-modeled coal resources. Geological modeling of the coal beds and some degree of mine planning, from basic prefeasibility to advanced, must already have been performed before this program can be used. United States Geological Survey mine planning is done from a very basic, prefeasibility standpoint, but the accuracy of CoalVal's output is a reflection of the accuracy of the data entered, both for mine costs and mine planning. The mining cost analysis is done by using mine cost models designed for the commonly employed, surface and underground mining methods utilized in the United States. CoalVal requires a Microsoft Windows? 98 or Windows? XP operating system and a minimum of 1 gigabyte of random access memory to perform operations. It will not operate on Microsoft Vista?, Windows? 7, or Macintosh? operating systems. The program will summarize the evaluation of an unlimited number of coal seams, haulage zones, tax entities, or other area delineations for a given coal property, coalfield, or basin. When the reader opens the CoalVal publication from the USGS website, options are provided to download the CoalVal publication manual and the CoalVal Program. The CoalVal report is divided into five specific areas relevant to the development and use of the CoalVal program: 1. Introduction to CoalVal Assumptions and Concepts. 2. Mine Model Assumption Details (appendix A). 3. CoalVal Project Tutorial (appendix B). 4. Program Description (appendix C). 5. Mine Model and Discounted Cash Flow Formulas (appendix D). The tutorial explains how to enter coal resource and quality data by mining method; program default values for production, operating, and cost variables; and ones own operating and cost variables into the program. Generated summary reports list the volume of resource in short tons available for mining, recoverable short tons by mining method; the seam or property being mined

  16. Odanacatib Inhibits Resistin-induced Hypertrophic H9c2 Cardiomyoblast Cells Through LKB1/AMPK Pathway

    Directory of Open Access Journals (Sweden)

    Xian Zheng

    2017-08-01

    Full Text Available ABSTRACT Odanacatib (ODN is a selective inhibitor of cathepsin K. The cysteine protease cathepsin K has been implicated in cardiac hypertrophy. Resistine is an adipokine which is identified to promote cardiac hypertrophy. Here, we hypothesize that ODN mitigates resistin-induced myocyte hypertrophy. Cell surface area and protein synthesis were measured after treatment with resistin and ODN in H9c2 cells. The expression of cardiomyocyte hypertrophy marker BNP and β-MHC was detected by RT-qPCR. The expression and phosphorylation of AMPK and LKB1 were analyzed with Western blot. Resistin could significantly increase cardiomyocyte cell surface area, protein synthesis, and embryonic gene BNP and β-MHC expression, inhibit phosphorylation of AMPK and LKB1. ODN could significantly reverse the effects of resistin. Collectively, our data suggest that ODN can inhibit cardiomyocyte hypertrophy induced by resistin and the underlying mechanism may be involved in LKB1/AMPK pathway.

  17. Application of dynamic programming to control khuzestan water resources system

    Science.gov (United States)

    Jamshidi, M.; Heidari, M.

    1977-01-01

    An approximate optimization technique based on discrete dynamic programming called discrete differential dynamic programming (DDDP), is employed to obtain the near optimal operation policies of a water resources system in the Khuzestan Province of Iran. The technique makes use of an initial nominal state trajectory for each state variable, and forms corridors around the trajectories. These corridors represent a set of subdomains of the entire feasible domain. Starting with such a set of nominal state trajectories, improvements in objective function are sought within the corridors formed around them. This leads to a set of new nominal trajectories upon which more improvements may be sought. Since optimization is confined to a set of subdomains, considerable savings in memory and computer time are achieved over that of conventional dynamic programming. The Kuzestan water resources system considered in this study is located in southwest Iran, and consists of two rivers, three reservoirs, three hydropower plants, and three irrigable areas. Data and cost benefit functions for the analysis were obtained either from the historical records or from similar studies. ?? 1977.

  18. Preparing Future Geoscience Professionals: Needs, Strategies, Programs, and Online Resources

    Science.gov (United States)

    Macdonald, H.; Manduca, C. A.; Ormand, C. J.; Dunbar, R. W.; Beane, R. J.; Bruckner, M.; Bralower, T. J.; Feiss, P. G.; Tewksbury, B. J.; Wiese, K.

    2011-12-01

    Geoscience faculty, departments, and programs play an important role in preparing future geoscience professionals. One challenge is supporting the diversity of student goals for future employment and the needs of a wide range of potential employers. Students in geoscience degree programs pursue careers in traditional geoscience industries; in geoscience education and research (including K-12 teaching); and opportunities at the intersection of geoscience and other fields (e.g., policy, law, business). The Building Strong Geoscience Departments project has documented a range of approaches that departments use to support the development of geoscience majors as professionals (serc.carleton.edu/departments). On the Cutting Edge, a professional development program, supports graduate students and post-doctoral fellows interested in pursuing an academic career through workshops, webinars, and online resources (serc.carleton.edu/NAGTWorkshops/careerprep). Geoscience departments work at the intersection of student interests and employer needs. Commonly cited program goals that align with employer needs include mastery of geoscience content; field experience; skill in problem solving, quantitative reasoning, communication, and collaboration; and the ability to learn independently and take a project from start to finish. Departments and faculty can address workforce issues by 1) implementing of degree programs that develop the knowledge, skills, and attitudes that students need, while recognizing that students have a diversity of career goals; 2) introducing career options to majors and potential majors and encouraging exploration of options; 3) advising students on how to prepare for specific career paths; 4) helping students develop into professionals, and 5) supporting students in the job search. It is valuable to build connections with geoscience employers, work with alumni and foster connections between students and alumni with similar career interests, collaborate with

  19. U.S. Geological Survey Mineral Resources Program - Science Supporting Mineral Resource Stewardship

    Science.gov (United States)

    Kropschot, S.J.

    2007-01-01

    The United States is the world's largest user of mineral resources. We use them to build our homes and cities, fertilize our food crops, and create wealth that allows us to buy goods and services. Individuals rarely use nonfuel mineral resources in their natural state - we buy light bulbs, not the silica, soda ash, lime, coal, salt, tungsten, copper, nickel, molybdenum, iron, manganese, aluminum, and zinc used to convert electricity into light. The USGS Mineral Resources Program (MRP) is the sole Federal source of scientific information and unbiased research on nonfuel mineral potential, production, and consumption, as well as on the environmental effects of minerals. The MRP also provides baseline geochemical, geophysical, and mineral-deposit data used to understand environmental issues related to extraction and use of mineral resources. Understanding how minerals, water, plants, and organisms interact contributes to our understanding of the environment, which is essential for maintaining human and ecosystem health. To support creation of economic and national security policies in a global context, MRP collects and analyzes data on essential mineral commodities from around the world.

  20. Development of synthetic analysis program concerning on the safety of energy resources

    Energy Technology Data Exchange (ETDEWEB)

    Chang, S. H.; Choi, S. S.; Cheong, Y. H.; Ahn, S. H.; Chang, W. J. [Atomic Creative Technology, Daejeon (Korea, Republic of)

    2007-03-15

    Methodology development of synthetic analysis of energy resources: build system methodology of synthetic analysis of energy resources. Development of web-based enquete program, develop web-based enquete program to support synthetic analysis of energy resources. Aggregation Software development, develop AHP algorithm and aggregation software for the synthetic analysis of energy resources.

  1. Creating organizational change through the Pain Resource Nurse program.

    Science.gov (United States)

    Paice, Judith A; Barnard, Cynthia; Creamer, Julie; Omerod, Kathleen

    2006-01-01

    Unrelieved pain remains a critical problem in health care. Barriers to improving the state of pain control include lack of education of health care professionals. Traditional quality improvement (QI) strategies directed toward educational interventions are rarely sufficient to change pain-related practice. PAIN RESOURCE NURSE (PRN) PROGRAM: The PRN program consists of a two-day course, quarterly in-services, regular newsletters, a listserv, individual meetings with PRNs and their managers to plan and conduct quality initiatives appropriate to their unit, as well as an optional clinical experience. Significant improvements were seen in knowledge and attitude of the participants, along with reduced turnover, improved patient satisfaction with pain control, a reduction in the prevalence of pain, and a greater percentage of patients who remembered speaking with a doctor or nurse about their pain (93% versus 89%). Establishing a PRN program entails conquering a number of management challenges common to any organizationwide QI project. The single most important step is building a shared priority among all those who must participate for success-in this case, nursing management. The PRN program is an effective strategy in creating organizational change to improve the state of pain control.

  2. Evaluation of resources for an interactive infection control instructional program.

    Science.gov (United States)

    Garland, Kandis V

    2014-04-01

    To evaluate educational resources used in developing and implementing an interactive infection control instructional program for first year (n=26) and second year (n=26) dental hygiene students in a baccalaureate program. An educator's toolkit was used to develop online and interactive learning modalities for teaching infection control content. Descriptive statistics were used to evaluate responses on a post instruction opinion survey on a 5-point Likert-type scale. Following the instructional program, most students reported on an opinion survey that they understood infection control principles (92% first year, 100% second year), felt prepared to work safely in clinic (96% first year, 100% second year) and liked working at their own pace (88% first year, 100% second year). First year students valued the online learning components and were less favorable toward supplemental textbook readings and the limited time to complete all 10 modules. Most second year students valued the interactive workshop but did not take the time to complete the online videos and did not watch all of them. Seventy-nine percent of second year students (n=20) preferred the interactive workshop method over traditional lecture instruction completed during their first year. This paper describes 1 institution's process of developing and implementing an infection control instructional program utilizing an educator's toolkit.

  3. Information resources for US Department of Energy pollution prevention programs

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, K.L.; Snowden-Swan, L.J.; Butner, R.S.

    1994-01-01

    In support of the US Department of Energy`s (DOE`s) pollution prevention efforts being conducted under the aegis of DOE`s Office of Environmental Restoration and Waste Management (EM) program, Pacific Northwest Laboratory was tasked with evaluating pollution prevention information resources. The goal of this activity was to improve the effectiveness of DOE`s pollution prevention activities through improved information flow, both within the complex, and more specifically, between DOE and other organizations that share similar pollution prevention challenges. This report presents our findings with respect to the role of information collection and dissemination within the complex, opportunities for teaming from successes of the private sector, and specific information needs of the DOE pollution prevention community. These findings were derived from a series of interviews with pollution prevention coordinators from across the DOE complex, review of DOE site and facility pollution prevention plans, and workshops with DOE information users as well as an information resources workshop that brought together information specialists from private industry, non-profit organizations, as well as state and regional pollution prevention assistance programs.

  4. Risk Management for Study Abroad Programs: Issues and Resources to Inform Program Development, Administration, and Training

    Science.gov (United States)

    Rhodes, Gary

    2014-01-01

    This chapter provides a practical background to the health and safety risks and challenges for U.S. colleges and universities and other program providers. Potential risks, field-based guidelines, good practices, and resources to support the management of risks by study abroad offices will be covered.

  5. Long Term Resource Monitoring Program procedures: fish monitoring

    Science.gov (United States)

    Ratcliff, Eric N.; Glittinger, Eric J.; O'Hara, T. Matt; Ickes, Brian S.

    2014-01-01

    This manual constitutes the second revision of the U.S. Army Corps of Engineers’ Upper Mississippi River Restoration-Environmental Management Program (UMRR-EMP) Long Term Resource Monitoring Program (LTRMP) element Fish Procedures Manual. The original (1988) manual merged and expanded on ideas and recommendations related to Upper Mississippi River fish sampling presented in several early documents. The first revision to the manual was made in 1995 reflecting important protocol changes, such as the adoption of a stratified random sampling design. The 1995 procedures manual has been an important document through the years and has been cited in many reports and scientific manuscripts. The resulting data collected by the LTRMP fish component represent the largest dataset on fish within the Upper Mississippi River System (UMRS) with more than 44,000 collections of approximately 5.7 million fish. The goal of this revision of the procedures manual is to document changes in LTRMP fish sampling procedures since 1995. Refinements to sampling methods become necessary as monitoring programs mature. Possible refinements are identified through field experiences (e.g., sampling techniques and safety protocols), data analysis (e.g., planned and studied gear efficiencies and reallocations of effort), and technological advances (e.g., electronic data entry). Other changes may be required because of financial necessity (i.e., unplanned effort reductions). This version of the LTRMP fish monitoring manual describes the most current (2014) procedures of the LTRMP fish component.

  6. Testosterone stimulates glucose uptake and GLUT4 translocation through LKB1/AMPK signaling in 3T3-L1 adipocytes.

    Science.gov (United States)

    Mitsuhashi, Kazuteru; Senmaru, Takafumi; Fukuda, Takuya; Yamazaki, Masahiro; Shinomiya, Katsuhiko; Ueno, Morio; Kinoshita, Shigeru; Kitawaki, Jo; Katsuyama, Masato; Tsujikawa, Muneo; Obayashi, Hiroshi; Nakamura, Naoto; Fukui, Michiaki

    2016-01-01

    Decreases in serum testosterone concentrations in aging men are associated with metabolic disorders. Testosterone has been reported to increase GLUT4-dependent glucose uptake in skeletal muscle cells and cardiomyocytes. However, studies on glucose uptake occurring in response to testosterone stimulation in adipocytes are currently not available. This study was designed to determine the effects of testosterone on glucose uptake in adipocytes. Glucose uptake was assessed with 2-[(3)H] deoxyglucose in 3T3-L1 adipocytes. GLUT4 translocation was evaluated in plasma membrane (PM) sheets and PM fractions by immunofluorescence and immunoblotting, respectively. Activation of GLUT4 translocation-related protein kinases, including Akt, AMPK, LKB1, CaMKI, CaMKII, and Cbl was followed by immunoblotting. Expression levels of androgen receptor (AR) mRNA and AR translocation to the PM were assessed by real-time RT-PCR and immunoblotting, respectively. The results showed that both high-dose (100 nM) testosterone and testosterone-BSA increased glucose uptake and GLUT4 translocation to the PM, independently of the intracellular AR. Testosterone and testosterone-BSA stimulated the phosphorylation of AMPK, LKB1, and CaMKII. The knockdown of LKB1 by siRNA attenuated testosterone- and testosterone-BSA-stimulated AMPK phosphorylation and glucose uptake. These results indicate that high-dose testosterone and testosterone-BSA increase GLUT4-dependent glucose uptake in 3T3-L1 adipocytes by inducing the LKB1/AMPK signaling pathway.

  7. Honokiol activates the LKB1–AMPK signaling pathway and attenuates the lipid accumulation in hepatocytes

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Min Suk; Kim, Jung Hwan; Kim, Hye Jung; Chang, Ki Churl; Park, Sang Won, E-mail: parksw@gnu.ac.kr

    2015-04-15

    Honokiol is a bioactive neolignan compound isolated from the species of Magnolia. This study was designed to elucidate the cellular mechanism by which honokiol alleviates the development of non-alcoholic steatosis. HepG2 cells were treated with honokiol for 1 h, and then exposed to 1 mM free fatty acid (FFA) for 24 h to simulate non-alcoholic steatosis in vitro. C57BL/6 mice were fed with a high-fat diet for 28 days, and honokiol (10 mg/kg/day) was daily treated. Honokiol concentration-dependently attenuated intracellular fat overloading and triglyceride (TG) accumulation in FFA-exposed HepG2 cells. These effects were blocked by pretreatment with an AMP-activated protein kinase (AMPK) inhibitor. Honokiol significantly inhibited sterol regulatory element-binding protein-1c (SREBP-1c) maturation and the induction of lipogenic proteins, stearoyl-CoA desaturase-1 (SCD-1) and fatty acid synthase (FAS) in FFA-exposed HepG2 cells, but these effects were blocked by pretreatment of an AMPK inhibitor. Honokiol induced AMPK phosphorylation and subsequent acetyl-CoA carboxylase (ACC) phosphorylation, which were inhibited by genetic deletion of liver kinase B1 (LKB1). Honokiol stimulated LKB1 phosphorylation, and genetic deletion of LKB1 blocked the effect of honokiol on SREBP-1c maturation and the induction of SCD-1 and FAS proteins in FFA-exposed HepG2 cells. Honokiol attenuated the increases in hepatic TG and lipogenic protein levels and fat accumulation in the mice fed with high-fat diet, while significantly induced LKB1 and AMPK phosphorylation. Taken together, our findings suggest that honokiol has an anti-lipogenic effect in hepatocytes, and this effect may be mediated by the LKB1–AMPK signaling pathway, which induces ACC phosphorylation and inhibits SREBP-1c maturation in hepatocytes. - Highlights: • Honokiol attenuates lipid accumulation induced by free fatty acid in hepatocyte. • Honokiol inhibits the increase in lipogenic enzyme levels induced by free fatty

  8. Financial Resources for Conducting Athletic Training Programs in the Collegiate and High School Settings

    OpenAIRE

    Rankin, James M.

    1992-01-01

    The distribution of resources to athletic training programs varies greatly, depending on the size and scope of the athletic program. No research has been found that assesses the differences in dollars allocated within various athletic training settings or assesses whether the different program levels allocate similar proportions of their resources to like categories of expenditures. In this study, I assessed the financial resources available to athletic training programs at major football NCA...

  9. A framework for evaluating and designing citizen science programs for natural resources monitoring.

    Science.gov (United States)

    Chase, Sarah K; Levine, Arielle

    2016-06-01

    We present a framework of resource characteristics critical to the design and assessment of citizen science programs that monitor natural resources. To develop the framework we reviewed 52 citizen science programs that monitored a wide range of resources and provided insights into what resource characteristics are most conducive to developing citizen science programs and how resource characteristics may constrain the use or growth of these programs. We focused on 4 types of resource characteristics: biophysical and geographical, management and monitoring, public awareness and knowledge, and social and cultural characteristics. We applied the framework to 2 programs, the Tucson (U.S.A.) Bird Count and the Maui (U.S.A.) Great Whale Count. We found that resource characteristics such as accessibility, diverse institutional involvement in resource management, and social or cultural importance of the resource affected program endurance and success. However, the relative influence of each characteristic was in turn affected by goals of the citizen science programs. Although the goals of public engagement and education sometimes complimented the goal of collecting reliable data, in many cases trade-offs must be made between these 2 goals. Program goals and priorities ultimately dictate the design of citizen science programs, but for a program to endure and successfully meet its goals, program managers must consider the diverse ways that the nature of the resource being monitored influences public participation in monitoring. © 2016 Society for Conservation Biology.

  10. Connecting students to institutions: the relationship between program resources and student retention in respiratory care education programs.

    Science.gov (United States)

    Ari, Arzu

    2009-09-01

    Respiratory care education programs are being held accountable for student retention. Increasing student retention is necessary for the respiratory therapy profession, which suffers from a shortage of qualified therapists needed to meet the increased demand. The present study investigated the relationship between student retention rate and program resources, in order to understand which and to what extent the different components of program resources predict student retention rate. The target population of this study was baccalaureate of science degree respiratory care education programs. After utilizing a survey research method, Pearson correlations and multiple regression analysis were used for data analysis. With a 63% response rate (n = 36), this study found a statistically significant relationship between program resources and student retention rate. Financial and personnel resources had a statistically significant positive relationship with student retention. The mean financial resources per student was responsible for 33% of the variance in student retention, while the mean personnel resources per student accounted for 12% of the variance in student retention. Program financial resources available to students was the single best predictor of program performance on student retention. Respiratory care education programs spending more money per student and utilizing more personnel in the program have higher mean performance in student retention. Therefore, respiratory care education programs must devote sufficient resources to retaining students so that they can produce more respiratory therapists and thereby make the respiratory therapy profession stronger.

  11. Promotion of Bilateral Cooperative Programs in Nuclear Human Resources Development

    Energy Technology Data Exchange (ETDEWEB)

    Lee, E. J.; Han, K. W.; Nam, Y. M. (and others)

    2009-08-15

    The purpose of this project is strengthening of bilateral cooperation with those countries for sharing Korea's technology, and providing of education and training on Korean experience regarding national nuclear policy, technology self reliance, and technology itself, in the field of nuclear power generation and the application of radioisotopes and radiation. This project covers an analysis on the need of nuclear human resource development in countries having interest in the introduction of nuclear power and/or promotion of the use of nuclear energy, and provision of courses on 'nuclear power policy, planning and management' and 'design and operation of nuclear research reactor, and application of radiation technology' along with the country specific needs. Education and training of key members in nuclear energy development from Egypt: It was implemented through bilateral cooperation and support by KOICA program. The first part, which targeted staff members from Egypt Nuclear Commission, was held for 2 months providing a KOICA course on policy, planning and management for nuclear power project, and second part was on the job training in Korea Hydro and Nuclear Power and Korea Institute of Nuclear Safety, KAERI respectively. On the job training of 1 scientist from Vietnam was implemented on the basis of bilateral cooperation in a research laboratory on radioactive waste treatment technology, at KAERI. Education and training for scientists from South East RCA countries were carried out for 11 participants from Vietnam, Thailand, Indonesia, China, Pakistan, Malaysia, Philippines, and Bangladesh. The course dealt with nuclear research reactor and radiation application technology. Development of nuclear education and training programs for key persons involved in nuclear power projects from countries of Middle East: The developed program consists of 15 courses addressing 3 technical levels, i.e. high level policy makers, middle level project

  12. GateWay Community College Water Resources Program Partnerships: An Opportunity for Program Success and Collaboration

    Science.gov (United States)

    Castaneda, M.

    2012-12-01

    GateWay Community College Water Resources Technologies (WRT) Program offers Certificate of Completions and Associate Degrees on Hydrologic Studies, Water Treatment and Wastewater Treatment. The program has been in existence since 1998 and has gone through several updates to meet the demand for professionals in those areas. The program includes theoretical and practical hands-on training in the monitoring of water quality and quantity as well as in water and industrial wastewater treatment. The WRT program offers online, face-to-face, and hybrid courses to address different student's needs for training. The program only Full-time faculty is supported by 15 adjunct- faculty professionals. Adjunct faculty is usually hired from a wide variety of professional people already working in the industry that have shown interest on teaching. Adjunct faculty also provide free tutoring to the WRT students when they are not teaching courses. The college Learning Center provides funding to support these tutoring activities. The program has an active Advisory Committee that provides guidance and recommends program changes to meet their training needs. This Advisory Committee is made of professionals from different federal, state, county agencies, and municipalities, private industry and consulting companies in the area. The Advisory Committee meets every year to provide feedback to GateWay on curriculum changes and commit to potential internship opportunities for the WRT students. Those internships (or voluntary work) are paid directly by the municipalities or agencies or can be paid by the GateWay WRT program. These internship jobs provides with an opportunity to actively promote the WRT program throughout the valley. The GateWay WRT program considers the Advisory Committee an essential component for the program success: the committee supports the program in recommending and acquiring the latest field equipment needed for the hands-on training. One of the main WRT program

  13. The Mentoring Toolkit 2.0: Resources for Developing Programs for Incarcerated Youth. Guide

    Science.gov (United States)

    Zaugg, Nathan; Jarjoura, Roger

    2017-01-01

    "The Mentoring Toolkit 2.0: Resources for Developing Programs for Incarcerated Youth" provides information, program descriptions, and links to important resources that can assist juvenile correctional facilities and other organizations to design effective mentoring programs for neglected and delinquent youth, particularly those who are…

  14. LKB1-AMPK modulates nutrient-induced changes in the mode of division of intestinal epithelial crypt cells in mice.

    Science.gov (United States)

    Blackmore, Katherine; Zhou, Weinan; Dailey, Megan J

    2017-09-01

    Nutrient availability influences intestinal epithelial stem cell proliferation and tissue growth. Increases in food result in a greater number of epithelial cells, villi height and crypt depth. We investigated whether this nutrient-driven expansion of the tissue is the result of a change in the mode of intestinal epithelial stem cell division and if LKB1-AMPK signaling plays a role. We utilized in vivo and in vitro experiments to test this hypothesis. C57BL/6J mice were separated into four groups and fed varying amounts of chow for 18 h: (1) ad libitum, (2) 50% of their average daily intake (3) fasted or (4) fasted for 12 h and refed. Mice were sacrificed, intestinal sections excised and immunohistochemically processed to determine the mitotic spindle orientation. Epithelial organoids in vitro were treated with no (0 mM), low (5 mM) or high (20 mM) amounts of glucose with or without an activator (Metformin) or inhibitor (Compound C) of LKB1-AMPK signaling. Cells were then processed to determine the mode of stem cell division. Fasted mice show a greater % of asymmetrically dividing cells compared with the other feeding groups. Organoids incubated with 0 mM glucose resulted in a greater % of asymmetrically dividing cells compared with the low or high-glucose conditions. In addition, LKB1-AMPK activation attenuated the % of symmetric division normally seen in high-glucose conditions. In contrast, LKB1-AMPK inhibition attenuated the % of asymmetric division normally seen in no glucose conditions. These data suggest that nutrient availability dictates the mode of division and that LKB1-AMPK mediates this nutrient-driven effect on intestinal epithelial stem cell proliferation. Impact statement The underlying cell biology of changes in the polarity of mitotic spindles and its relevance to tissue growth is a new concept and, thus, these data provide novel findings to begin to explain how this process contributes to the regeneration and growth of tissues. We

  15. E-resource for learning programming in Python

    OpenAIRE

    Strnad, Mojca

    2011-01-01

    For a better understanding of all computer programs, with which nowadays we are surrounded, the demand for knowing programming languages has nowadays been growing. As more and more people have been interested in learning programming languages, even the basic knowledge of only one programming language is very helpful. As there are nowadays already many programming languages, we decided for the programming language Python. It is anticipated as a programming language which is easy to read an...

  16. Initial Analyses of Change Detection Capabilities and Data Redundancies in the Long Term Resource Monitoring Program

    National Research Council Canada - National Science Library

    Lubinski, Kenneth

    2001-01-01

    Evaluations of Long Term Resource Monitoring Program sampling designs for water quality, fish, aquatic vegetation, and macroinvertebrates were initiated in 1999 by analyzing data collected since 1992...

  17. 75 FR 27575 - Agency Information Collection Activities: State Water Resources Research Institute Program Annual...

    Science.gov (United States)

    2010-05-17

    ... encourages regional cooperation among institutes in research into areas of water management, development, and... Geological Survey Agency Information Collection Activities: State Water Resources Research Institute Program... Water Resources Research Act of 1984, as amended (42 U.S.C. 10301 et seq.), authorizes a water resources...

  18. 1976 Inter-university symposium on renewable resource assessment and programming: executive summary

    Science.gov (United States)

    Billy G. Pemberton

    1977-01-01

    The Forest and Rangeland Renewable Resources Planning Act of 1974 directs the Secretary of Agriculture to prepare an assessment of the nation's renewable resources and a program that will assure an adequate future supply of these resources. Responsibility for this work is assigned to the Forest Service. An inter-university symposium was held in 1976 to evaluate...

  19. The Impacts of the Great Recession on State Natural Resource Extension Programs

    Science.gov (United States)

    Serenari, Christopher; Peterson, M. Nils; Bardon, Robert E.; Brown, Robert D.

    2013-01-01

    The Great Recession contributed to major budget cuts for natural resource Extension programs in the United States. Despite the potentially large cuts, their impacts and how Extension has adapted their programs have not been evaluated. We begin addressing these needs with surveys of Association of Natural Resource Extension Professionals members…

  20. The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice

    Directory of Open Access Journals (Sweden)

    Sagen Zac-Varghese

    2014-11-01

    Full Text Available Liver kinase B1 (LKB1; also known as STK11 is a serine/threonine kinase and tumour suppressor that is mutated in Peutz-Jeghers syndrome (PJS, a premalignant syndrome associated with the development of gastrointestinal polyps. Proglucagon-expressing enteroendocrine cells are involved in the control of glucose homeostasis and the regulation of appetite through the secretion of gut hormones such as glucagon-like peptide-1 (GLP-1 and peptide tyrosine tyrosine (PYY. To determine the role of LKB1 in these cells, we bred mice bearing floxed alleles of Lkb1 against animals carrying Cre recombinase under proglucagon promoter control. These mice (GluLKB1KO were viable and displayed near-normal growth rates and glucose homeostasis. However, they developed large polyps at the gastro-duodenal junction, and displayed premature mortality (death from 120 days of age. Histological analysis of the polyps demonstrated that they had a PJS-like appearance with an arborising smooth-muscle core. Circulating GLP-1 levels were normal in GluLKB1KO mice and the polyps expressed low levels of the peptide, similar to levels in the neighbouring duodenum. Lineage tracing using a Rosa26tdRFP transgene revealed, unexpectedly, that enterocytes within the polyps were derived from non-proglucagon-expressing precursors, whereas connective tissue was largely derived from proglucagon-expressing precursors. Developmental studies in wild-type mice suggested that a subpopulation of proglucagon-expressing cells undergo epithelial-mesenchymal transition (EMT to become smooth-muscle-like cells. Thus, it is likely that polyps in the GluLKB1KO mice developed from a unique population of smooth-muscle-like cells derived from a proglucagon-expressing precursor. The loss of LKB1 within this subpopulation seems to be sufficient to drive tumorigenesis.

  1. Employee Assistance Programs: A New Human Resource Approach.

    Science.gov (United States)

    Gould, Gary M.; Schneider, John H.

    1983-01-01

    After reviewing industrial sector program results, University of Southern California administration officials agreed to finance a counseling and consulting program for USC employees. The program serves as an adjunct to the personnel office in areas such as outplacement, sexual harassment, and conflict resolution. (MLW)

  2. A Running Start: Resource Guide for Youth Running Programs

    Science.gov (United States)

    Jenny, Seth; Becker, Andrew; Armstrong, Tess

    2016-01-01

    The lack of physical activity is an epidemic problem among American youth today. In order to combat this, many schools are incorporating youth running programs as a part of their comprehensive school physical activity programs. These youth running programs are being implemented before or after school, at school during recess at the elementary…

  3. 77 FR 4578 - Alaska Region's Subsistence Resource Commission (SRC) Program

    Science.gov (United States)

    2012-01-30

    ... The proposed meeting agenda for each meeting includes the following: 1. Call to Order 2. Welcome and..., Resources and Visitor Protection) 8. Federal Subsistence Board Updates 9. Alaska Board of Game Updates 10...

  4. The 2017 Space Resources Roundtable and New Space Resources Graduate Program at Colorado School of Mines

    Science.gov (United States)

    Abbud-Madrid, A.

    2017-10-01

    For eighteen years, SRR has brought together interested individuals from the space exploration community, the mining and minerals industries, and the financial sector to discuss issues related to the ISRU of lunar, asteroidal, and martian resources.

  5. Low-temperature resource assessment program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lienau, P.J. [Oregon Inst. of Tech., Klamath Falls, OR (United States). Geo-Heat Center; Ross, H. [Utah Univ., Salt Lake City, UT (United States). Earth Sciences and Resources Inst.

    1996-02-01

    The US Department of Energy - Geothermal Division (DOE/GD) recently sponsored the Low-Temperature Resource Assessment project to update the inventory of the nation`s low- and moderate-temperature geothermal resources and to encourage development of these resources. A database of 8,977 thermal wells and springs that are in the temperature range of 20{degrees}C to 150{degrees}C has been compiled for ten western states, an impressive increase of 82% compared to the previous assessments. The database includes location, descriptive data, physical parameters, water chemistry and references for sources of data. Computer-generated maps are also available for each state. State Teams have identified 48 high-priority areas for near-term comprehensive resource studies and development. Resources with temperatures greater than 50{degrees}C located within 8 km of a population center were identified for 271 collocated cities. Geothermal energy cost evaluation software has been developed to quickly identify the cost of geothermally supplied heat to these areas in a fashion similar to that used for conventionally fueled heat sources.

  6. Final Report Low-temperature Resource Assessment Program

    Energy Technology Data Exchange (ETDEWEB)

    Lienau, P.J. [Geo-Heat Center, Oregon Institute of Technology, Klamath Falls, OR (US); Ross, H. [Earth Sciences and Resources Institute, University of Utah

    1996-02-01

    The U.S. Department of Energy - Geothermal Division (DOE/GD) recently sponsored the Low-Temperature Resource Assessment project to update the inventory of the nation's low- and moderate-temperature geothermal resources and to encourage development of these resources. A database of 8,977 thermal wells and springs that are in the temperature range of 20 degrees Celsius to 150 degrees Celsius has been compiled for ten western states, an impressive increase of 82% compared to the previous assessments. The database includes location, descriptive data, physical parameters, water chemistry and references for sources of data. Computer-generated maps are also available for each state. State Teams have identified 48 high-priority areas for near-term comprehensive resource studies and development. Resources with temperatures greater than 50 degrees Celsius located within 8 km of a population center were identified for 271 collocated cities. Geothermal energy costevaluation software has been developed to quickly identify the cost of geothermally supplied heat to these areas in a fashion similar to that used for conventionally fueled heat sources.

  7. ``Dark Skies are a Universal Resource'' Programs Planned for the International Year of Astronomy

    Science.gov (United States)

    Walker, C. E.; Berglund, K.; Bueter, C.; Crelin, B.; Duriscoe, D.; Moore, C.; Gauthier, A.; Gay, P. L.; Foster, T.; Heatherly, S. A.; Maddalena, R.; Mann, T.; Patten, K.; Pompea, S. M.; Sparks, R.; Schaaf, F.; Simmons, M.; Smith, C.; Smith, M.; Tafreshi, B.

    2008-11-01

    In an effort to help more people appreciate the ongoing loss of a dark night sky for much of the world's population and to raise public knowledge about diverse impacts of excess artificial lighting on local environments, the International Year of Astronomy's Dark Skies Working Group has established six ``Dark Skies'' programs and six ``Dark Skies'' resources. The Dark Skies programs include GLOBE at Night (with Earth Hour), Astronomy Nights in the [National] Parks, Dark Skies Discovery Sites, Quiet Skies, Good Neighbor Lighting, and a digital photography contest. Resources include the light education toolkit, the ``Let There Be Night'' DVD and planetarium program, the 6-minute video, online interactions like Second Life, podcasts, and traveling exhibits. The programs and resources are summarized here, as they were in a poster for the June 2008 ASP/AAS conference. For more information on these programs and resources, visit http://astronomy2009.us/darkskies/.

  8. Abstract: Rwanda Human Resources for Health Program: Genesis ...

    African Journals Online (AJOL)

    Abstract. Background In 2010, the Permanent Secretary of the Rwanda Ministry of Health reached out to select US schools of nursing and midwifery to request support for a program to dramatically improve nursing and midwifery education and practice. This poster described the process that led to the Rwanda HRH Program ...

  9. Childhood Lead Poisoning: Developing Prevention Programs and Mobilizing Resources.

    Science.gov (United States)

    Rochow, K. W. James

    The current approach to dealing with childhood lead poisoning has led to repeated diagnoses of poisoning because such children are treated and then returned to their hazardous environments. This handbook describes in detail the program requirements for effective childhood lead poisoning prevention programs at the local level based on the…

  10. Mexico's "Telesecundaria" Program and Equitable Access to Resources

    Science.gov (United States)

    Craig, Dana; Etcheverry, Jose; Ferris, Stefan

    2016-01-01

    This Note provides an analysis of Mexico's "Telesecundaria" program within the context of Mexico's new education reform framework offering a succinct background of the project, as well as key policy lessons that can be useful for other jurisdictions interested in the development of distance education programs. This Note uses a literature…

  11. 1979-1980 Geothermal Resource Assessment Program in Washington

    Energy Technology Data Exchange (ETDEWEB)

    Korosec, M.A.; Schuster, J.E.

    1980-01-01

    Separate abstracts were prepared for seven papers. Also included are a bibliography of geothermal resource information for the State of Washington, well temperature information and locations in the State of Washington, and a map of the geology of the White Pass-Tumac Mountain Area, Washington. (MHR)

  12. Cloud resource orchestration programming : Overview, issues and directions

    NARCIS (Netherlands)

    Ranjan, Rajiv; Benatallah, Boualem; Dustdar, Schahram; Papazoglou, M.

    Cloud computing provides on-demand access to affordable hardware (e.g., multi-core CPUs, GPUs, disks, and networking equipment) and software (e.g., databases, application servers, load-balancers, data processing frameworks, etc.) resources. The pervasiveness and power of cloud computing alleviates

  13. Renewable Fuel Standard Program (RFS1): Final Rule Additional Resources

    Science.gov (United States)

    The final rule of fuels and fuel additives: renewable fuel standard program is published on May 1, 2007 and is effective on September 1, 2007. You will find the links to this final rule and technical amendments supporting this rule.

  14. Yucca Mountain Biological Resources Monitoring Program; Annual report, FY91

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-01-01

    The US Department of Energy (DOE) is required by the Nuclear Waste Policy Act of 1982 (as amended in 1987) to study and characterize Yucca Mountain as a possible site for a geologic repository for high-level nuclear waste. During site characterization, the DOE will conduct a variety of geotechnical, geochemical, geological, and hydrological studies to determine the suitability of Yucca Mountain as a repository. To ensure that site characterization activities (SCA) do not adversely affect the Yucca Mountain area, an environmental program has been implemented to monitor and mitigate potential impacts and to ensure that activities comply with applicable environmental regulations. This report describes the activities and accomplishments during fiscal year 1991 (FY91) for six program areas within the Terrestrial Ecosystem component of the YMP environmental program. The six program areas are Site Characterization Activities Effects, Desert Tortoises, Habitat Reclamation, Monitoring and Mitigation, Radiological Monitoring, and Biological Support.

  15. Yucca Mountain biological resources monitoring program; Annual report FY92

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-02-01

    The US Department of Energy (DOE) is required by the Nuclear Waste Policy Act of 1982 (as amended in 1987) to study and characterize Yucca Mountain as a potential site for a geologic repository for high-level nuclear waste. During site characterization, the DOE will conduct a variety of geotechnical, geochemical, geological, and hydrological studies to determine the suitability of Yucca Mountain as a potential repository. To ensure that site characterization activities (SCA) do not adversely affect the environment at Yucca Mountain, an environmental program has been implemented to monitor and mitigate potential impacts and ensure activities comply with applicable environmental regulations. This report describes the activities and accomplishments of EG&G Energy Measurements, Inc. (EG&G/EM) during fiscal year 1992 (FY92) for six program areas within the Terrestrial Ecosystem component of the YMP environmental program. The six program areas are Site Characterization Effects, Desert Tortoises, Habitat Reclamation, Monitoring and Mitigation, Radiological Monitoring, and Biological Support.

  16. Genetic and epigenetic alterations of the LKB1 gene and their associations with mutations in TP53 and EGFR pathway genes in Korean non-small cell lung cancers.

    Science.gov (United States)

    Lee, Su Man; Choi, Jin Eun; Na, Yeon Kyung; Lee, Eun Jin; Lee, Won Kee; Choi, Yi Young; Yoon, Ghil Suk; Jeon, Hyo-Sung; Kim, Dong Sun; Park, Jae Yong

    2013-08-01

    Liver kinase 1 (LKB1) plays a critical barrier role in lung tumorigenesis by controlling initiation, differentiation and metastasis. We searched for genetic and epigenetic alterations of the LKB1 gene in Korean non-small cell lung cancers (NSCLCs) and correlated the results with clinicopathological features. We also investigated the relationship between genetic and epigenetic alterations of LKB1 and mutations in the TP53 gene and epidermal growth factor receptor (EGFR) pathway genes. A total of 159 NSCLCs were analyzed for loss of heterozygosity (LOH) at microsatellite loci D19S886, and D19S878. Mutations and methylation status of LKB1 were examined by direct sequencing and a methylation-specific polymerase chain reaction, respectively. A somatic mutation was found in one of the 159 tumors. LOH and promoter methylation was detected in 19.5% (31/159) and 13.2% (21/159) of the tumors, respectively. Four of the 159 tumors had concomitant LOH and methylation of LKB1. In total, 30.2% of the 159 NSCLCs harbored LKB1 LOH or promoter methylation, which were correlated with down-regulation of gene expression. LKB1 LOH was more frequent in males, smokers, and tumors with a TP53 mutation than in females, never-smokers, and tumors without a TP53 mutation, respectively. However, no significant correlation between LKB1 alterations and mutations in EGFR pathway genes was found. These results suggest that the prevalence of LKB1 genetic and epigenetic alterations in NSCLCs vary depending on patient ethnicity. Our results show that LKB1 alterations often occur simultaneously with mutations in EGFR pathway genes. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  17. Parkinson’s Disease Biomarkers Program Data Management Resource (PDBP DMR)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The NINDS Parkinson’s Disease (PD) Biomarkers Program Data Management Resource enables web-based data entry for clinical studies supporting PD biomarker development,...

  18. ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

    Science.gov (United States)

    Zeqiraj, Elton; Filippi, Beatrice Maria; Goldie, Simon; Navratilova, Iva; Boudeau, Jérôme; Deak, Maria; Alessi, Dario R.; van Aalten, Daan M. F.

    2009-01-01

    Pseudokinases lack essential residues for kinase activity, yet are emerging as important regulators of signal transduction networks. The pseudokinase STRAD activates the LKB1 tumour suppressor by forming a heterotrimeric complex with LKB1 and the scaffolding protein MO25. Here, we describe the structure of STRADα in complex with MO25α. The structure reveals an intricate web of interactions between STRADα and MO25α involving the αC-helix of STRADα, reminiscent of the mechanism by which CDK2 interacts with cyclin A. Surprisingly, STRADα binds ATP and displays a closed conformation and an ordered activation loop, typical of active protein kinases. Inactivity is accounted for by nonconservative substitution of almost all essential catalytic residues. We demonstrate that binding of ATP enhances the affinity of STRADα for MO25α, and conversely, binding of MO25α promotes interaction of STRADα with ATP. Mutagenesis studies reveal that association of STRADα with either ATP or MO25α is essential for LKB1 activation. We conclude that ATP and MO25α cooperate to maintain STRADα in an “active” closed conformation required for LKB1 activation. It has recently been demonstrated that a mutation in human STRADα that truncates a C-terminal region of the pseudokinase domain leads to the polyhydramnios, megalencephaly, symptomatic epilepsy (PMSE) syndrome. We demonstrate this mutation destabilizes STRADα and prevents association with LKB1. In summary, our findings describe one of the first structures of a genuinely inactive pseudokinase. The ability of STRADα to activate LKB1 is dependent on a closed “active” conformation, aided by ATP and MO25α binding. Thus, the function of STRADα is mediated through an active kinase conformation rather than kinase activity. It is possible that other pseudokinases exert their function through nucleotide binding and active conformations. PMID:19513107

  19. ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.

    Science.gov (United States)

    Zeqiraj, Elton; Filippi, Beatrice Maria; Goldie, Simon; Navratilova, Iva; Boudeau, Jérôme; Deak, Maria; Alessi, Dario R; van Aalten, Daan M F

    2009-06-09

    Pseudokinases lack essential residues for kinase activity, yet are emerging as important regulators of signal transduction networks. The pseudokinase STRAD activates the LKB1 tumour suppressor by forming a heterotrimeric complex with LKB1 and the scaffolding protein MO25. Here, we describe the structure of STRADalpha in complex with MO25alpha. The structure reveals an intricate web of interactions between STRADalpha and MO25alpha involving the alphaC-helix of STRADalpha, reminiscent of the mechanism by which CDK2 interacts with cyclin A. Surprisingly, STRADalpha binds ATP and displays a closed conformation and an ordered activation loop, typical of active protein kinases. Inactivity is accounted for by nonconservative substitution of almost all essential catalytic residues. We demonstrate that binding of ATP enhances the affinity of STRADalpha for MO25alpha, and conversely, binding of MO25alpha promotes interaction of STRADalpha with ATP. Mutagenesis studies reveal that association of STRADalpha with either ATP or MO25alpha is essential for LKB1 activation. We conclude that ATP and MO25alpha cooperate to maintain STRADalpha in an "active" closed conformation required for LKB1 activation. It has recently been demonstrated that a mutation in human STRADalpha that truncates a C-terminal region of the pseudokinase domain leads to the polyhydramnios, megalencephaly, symptomatic epilepsy (PMSE) syndrome. We demonstrate this mutation destabilizes STRADalpha and prevents association with LKB1. In summary, our findings describe one of the first structures of a genuinely inactive pseudokinase. The ability of STRADalpha to activate LKB1 is dependent on a closed "active" conformation, aided by ATP and MO25alpha binding. Thus, the function of STRADalpha is mediated through an active kinase conformation rather than kinase activity. It is possible that other pseudokinases exert their function through nucleotide binding and active conformations.

  20. ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.

    Directory of Open Access Journals (Sweden)

    Elton Zeqiraj

    2009-06-01

    Full Text Available Pseudokinases lack essential residues for kinase activity, yet are emerging as important regulators of signal transduction networks. The pseudokinase STRAD activates the LKB1 tumour suppressor by forming a heterotrimeric complex with LKB1 and the scaffolding protein MO25. Here, we describe the structure of STRADalpha in complex with MO25alpha. The structure reveals an intricate web of interactions between STRADalpha and MO25alpha involving the alphaC-helix of STRADalpha, reminiscent of the mechanism by which CDK2 interacts with cyclin A. Surprisingly, STRADalpha binds ATP and displays a closed conformation and an ordered activation loop, typical of active protein kinases. Inactivity is accounted for by nonconservative substitution of almost all essential catalytic residues. We demonstrate that binding of ATP enhances the affinity of STRADalpha for MO25alpha, and conversely, binding of MO25alpha promotes interaction of STRADalpha with ATP. Mutagenesis studies reveal that association of STRADalpha with either ATP or MO25alpha is essential for LKB1 activation. We conclude that ATP and MO25alpha cooperate to maintain STRADalpha in an "active" closed conformation required for LKB1 activation. It has recently been demonstrated that a mutation in human STRADalpha that truncates a C-terminal region of the pseudokinase domain leads to the polyhydramnios, megalencephaly, symptomatic epilepsy (PMSE syndrome. We demonstrate this mutation destabilizes STRADalpha and prevents association with LKB1. In summary, our findings describe one of the first structures of a genuinely inactive pseudokinase. The ability of STRADalpha to activate LKB1 is dependent on a closed "active" conformation, aided by ATP and MO25alpha binding. Thus, the function of STRADalpha is mediated through an active kinase conformation rather than kinase activity. It is possible that other pseudokinases exert their function through nucleotide binding and active conformations.

  1. Citizen science and natural resource governance: program design for vernal pool policy innovation

    OpenAIRE

    Bridie McGreavy; Aram J. K. Calhoun; Jessica Jansujwicz; Vanessa Levesque

    2016-01-01

    Effective natural resource policy depends on knowing what is needed to sustain a resource and building the capacity to identify, develop, and implement flexible policies. This retrospective case study applies resilience concepts to a 16-year citizen science program and vernal pool regulatory development process in Maine, USA. We describe how citizen science improved adaptive capacities for innovative and effective policies to regulate vernal pools. We identified two core program elements that...

  2. A chance-constrained programming model to allocate wildfire initial attack resources for a fire season

    Science.gov (United States)

    Yu Wei; Michael Bevers; Erin Belval; Benjamin Bird

    2015-01-01

    This research developed a chance-constrained two-stage stochastic programming model to support wildfire initial attack resource acquisition and location on a planning unit for a fire season. Fire growth constraints account for the interaction between fire perimeter growth and construction to prevent overestimation of resource requirements. We used this model to examine...

  3. 78 FR 46597 - Agency Information Collection Activities: State Water Resources Research Institute Program Annual...

    Science.gov (United States)

    2013-08-01

    ... research into areas of water management, development, and conservation that have a regional or national....S. Geological Survey Agency Information Collection Activities: State Water Resources Research... Water Resources (NIWR) USGS Competitive Grant Program. As required by the Paperwork Reduction Act (PRA...

  4. 78 FR 23288 - Proposed Information Collection: State Water Resources Research Institute Program; Annual...

    Science.gov (United States)

    2013-04-18

    ... research into areas of water management, development, and conservation that have a regional or national... Geological Survey Proposed Information Collection: State Water Resources Research Institute Program; Annual... collection (IC) to renew approval of the paperwork requirements for ``National Institutes for Water Resources...

  5. 36 CFR 261.3 - Interfering with a Forest officer, volunteer, or human resource program enrollee or giving false...

    Science.gov (United States)

    2010-07-01

    ... officer, volunteer, or human resource program enrollee or giving false report to a Forest officer. 261.3... General Prohibitions § 261.3 Interfering with a Forest officer, volunteer, or human resource program..., intimidating, or intentionally interfering with any Forest officer, volunteer, or human resource program...

  6. Oregon Low-Temperature-Resource Assessment Program. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    Priest, G.R.; Black, G.L.; Woller, N.M.

    1981-01-01

    Numerous low-temperature hydrothermal systems are available for exploitation throughout the Cascades and eastern Oregon. All of these areas have heat flow significantly higher than crustal averages and many thermal aquifers. In northeastern Oregon, low temperature geothermal resources are controlled by regional stratigraphic aquifers of the Columbia River Basalt Group at shallow depths and possibly by faults at greater depths. In southeastern Oregon most hydrothermal systems are of higher temperature than those of northeastern Oregon and are controlled by high-angle fault zones and layered volcanic aquifers. The Cascades have very high heat flow but few large population centers. Direct use potential in the Cascades is therefore limited, except possibly in the cities of Oakridge and Ashland, where load may be great enough to stimulate development. Absence of large population centers also inhibits initial low temperature geothermal development in eastern Oregon. It may be that uses for the abundant low temperature geothermal resources of the state will have to be found which do not require large nearby population centers. One promising use is generation of electricity from freon-based biphase electrical generators. These generators will be installed on wells at Vale and Lakeview in the summer of 1982 to evaluate their potential use on geothermal waters with temperatures as low as 80/sup 0/C (176/sup 0/F).

  7. FFTF and Advanced Reactors Transition Program Resource Loaded Schedule

    Energy Technology Data Exchange (ETDEWEB)

    GANTT, D.A.

    2000-10-31

    This Resource Load Schedule (RLS) addresses two missions. The Advanced Reactors Transition (ART) mission, funded by DOE-EM, is to transition assigned, surplus facilities to a safe and compliant, low-cost, stable, deactivated condition (requiring minimal surveillance and maintenance) pending eventual reuse or D&D. Facilities to be transitioned include the 309 Building Plutonium Recycle Test Reactor (PRTR) and Nuclear Energy Legacy facilities. This mission is funded through the Environmental Management (EM) Project Baseline Summary (PBS) RL-TP11, ''Advanced Reactors Transition.'' The second mission, the Fast Flux Test Facility (FFTF) Project, is funded through budget requests submitted to the Office of Nuclear Energy, Science and Technology (DOE-NE). The FFTF Project mission is maintaining the FFTF, the Fuels and Materials Examination Facility (FMEF), and affiliated 400 Area buildings in a safe and compliant standby condition. This mission is to preserve the condition of the plant hardware, software, and personnel in a manner not to preclude a plant restart. This revision of the Resource Loaded Schedule (RLS) is based upon the technical scope in the latest revision of the following project and management plans: Fast Flux Test Facility Standby Plan (Reference 1); Hanford Site Sodium Management Plan (Reference 2); and 309 Building Transition Plan (Reference 4). The technical scope, cost, and schedule baseline is also in agreement with the concurrent revision to the ART Fiscal Year (FY) 2001 Multi-Year Work Plan (MYWP), which is available in an electronic version (only) on the Hanford Local Area Network, within the ''Hanford Data Integrator (HANDI)'' application.

  8. Yoga for Stress Management Program as a Complementary Alternative Counseling Resource in a University Counseling Center

    Science.gov (United States)

    Milligan, Colleen K.

    2006-01-01

    A Yoga for Stress Management Program (YSMP) that served as a complementary alternative therapy resource was successfully implemented at a midsize, predominantly undergraduate university. It was offered in addition to traditional treatments for student mental health. Counselors, Residence Life staff, and faculty found that the program was useful…

  9. Phase III Executive Summary. Evaluation of the Child and Family Resource Program (CFRP).

    Science.gov (United States)

    Nauta, Marrit J.

    The Child and Family Resource Program (CFRP) is a family-oriented child development program initiated by the Administration for Children, Youth and Families to provide support services to low-income families and their children. This report summarizes preliminary findings based on the first year and a half of CFRP evalution. Following the brief…

  10. Description and Evaluation of 1972 Summer Training Program for Paraprofessionals in Occupational Resource Centers.

    Science.gov (United States)

    Leland, Arthur L.; And Others

    A three-week intensive training program is described for preparing paraprofessionals to organize, develop, and establish Occupational Resource Centers (ORC) in elementary and secondary schools and related community agencies. The training program is based on a specific task analysis of the position of developing and operating an ORC. A behavior…

  11. 78 FR 23290 - Renewal of Agency Information Collection for Energy Resource Development Program Grants

    Science.gov (United States)

    2013-04-18

    ... Bureau of Indian Affairs Renewal of Agency Information Collection for Energy Resource Development Program... Number: 1076-0174. Title: Energy and Mineral Development Program Grants. Brief Description of Collection... comments on the renewal of Office of Management and Budget (OMB) approval for the collection of information...

  12. Five Years Later: Predicting Student Use of Journals in a New Water Resources Graduate Program

    Science.gov (United States)

    Wirth, Andrea A.; Mellinger, Margaret

    2011-01-01

    Using citation analysis, the authors examined the journals cited in theses and dissertations over the first five years of the Water Resources Graduate Program at Oregon State University. These journal titles were compared to the titles predicted as being important in the 2003 Oregon State University Libraries new program (Category I) review. A…

  13. Key Resources for Creating Online Nutrition Education for Those Participating in Supplemental Nutrition Assistance Program Education

    Science.gov (United States)

    Stosich, Marie C.; LeBlanc, Heidi; Kudin, Janette S.; Christofferson, Debra

    2016-01-01

    Internet-based nutrition education is becoming an important tool in serving the rural, low-income community, yet the task of creating such programming can be daunting. The authors describe the key resources used in developing an Internet-based nutrition education program for those participating in Supplemental Nutrition Assistance Program…

  14. Snakes. A Conservation Education Program of the Department of Fish and Wildlife Resources.

    Science.gov (United States)

    Hubbard, Kelly; Theiss, Nancy S.

    The Kentucky Department of Fish and Wildlife Resources is charged with the responsibility to preserve, protect, and perpetuate the fish and wildlife in Kentucky. Involved in this broad program are a number of services, including the Wildlife Conservation Education Program. During the months of September through April, Conservation Club leaders…

  15. Adult volunteerism in Pennsylvania 4-H natural resources programs for youth

    Science.gov (United States)

    Smith, Sanford Sherrick

    2001-07-01

    Pennsylvania's 4-H Youth Development Program relies on adult volunteers to reach youth with educational information and opportunities. Finding adults willing to do this volunteer work is challenging. This study looks at the current status of adult volunteerism with natural resources 4-H projects, and seeks to understand potential volunteers. The literature has much to offer in regards to general volunteer trends, management, motivations, and task preferences; however, few studies focus on volunteers in natural resources or environmental education. A telephone survey conducted with county 4-H agents revealed that only 3.2% of Pennsylvania's 4-H volunteers work with natural resources projects in 56 out of 67 counties, and that very few volunteers have any formal background in natural resources. Semi-structured interviews with 41 adult volunteers currently working with natural resources projects explored volunteer demographics, history, program design preferences, and ideas for seeking more volunteers. Findings from the telephone survey and the semi-structured interviews were used to generate a mail survey with large, random samples from three population groups: (1) 4-H Volunteers, (2) 4-H Parents, and (3) Natural Resources Professionals. Confidence with youth and subject matter, and adult willingness to volunteer was explored for each of the groups in relation to background, demographic characteristics, motivational needs, past and present volunteer activity, personal interests, and program design importance. Natural resources subject matter confidence was shown to be the most significant variable determining willingness to volunteer for all three groups. The variables that contributed to subject matter and youth confidence varied for each population. Key variables effecting willingness to volunteer included outdoor activity level, personal interest in natural resources, the need to fulfill feelings of social responsibility, and confidence with youth. Program design

  16. Hydrologic resources management program. FY 1995 progress report

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D.K. [comp.; Esser, B.K.; Kenneally, J.M. [and others

    1996-03-01

    This report presents the results of FY 1995 technical studies conducted by the Lawrence Livermore National Laboratory (LLNL) as part of the Hydrology and Radionuclide Migration Program (HRMP), a multi-agency program sponsored by the U.S. Department of Energy, Nevada Operations Office (DOE/NV), to address the environmental consequences of nuclear weapons testing at the Nevada Test Site (NTS). A priority is to better characterize the complex near-field environment in order to assess and predict the movement of radionuclides in groundwater. Other participating organizations include the Los Alamos National Laboratory (LANL), the U.S. Geological Survey (USGS) and the Desert Research Institute (DRI) of the University of Nevada. A radiologic source term in excess of 10{sup 8} curies of tritium, fission products, activation products and actinides is residual from more than three decades of underground nuclear weapons testing at the Nevada Test Site (NTS). Burial depths to insure containment of these explosions necessitated firing approximately one third of the more than 800 underground nuclear tests within one cavity radius or below the static water table. Work at LLNL has focused on studies of radionuclide transport under saturated, partially saturated or unsaturated conditions as well as investigations of the stable, radiogenic and cosmogenic isotope systematics of NTS groundwaters. LLNL has prioritized these studies because of the significance for potential radionuclide migration at the Nevada Test Site. LLNL utilizes expertise in nuclear weapons testing, radiochemical diagnostics, nuclear test phenomenology, mass spectrometry, aqueous geochemistry and field and laboratory studies of radionuclide migration to bring a unique measurement and interpretative capability to this research.

  17. Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss

    Science.gov (United States)

    Andrade-Vieira, Rafaela; Goguen, Donna; Bentley, Heidi A.; Bowen, Chris V.; Marignani, Paola A.

    2014-01-01

    Cancer therapies that simultaneously target activated mammalian target of rapamycin (mTOR) and cell metabolism are urgently needed. The goal of our study was to identify therapies that effectively inhibited both mTOR activity and cancer cell metabolism in primary tumors in vivo. Using our mouse model of spontaneous breast cancer promoted by loss of LKB1 expression in an ErbB2 activated model; referred to as LKB1−/−NIC mice, we evaluated the effect of novel therapies in vivo on primary tumors. Treatment of LKB1−/−NIC mice with AZD8055 and 2-DG mono-therapies significantly reduced mammary gland tumorigenesis by inhibiting mTOR pathways and glycolytic metabolism; however simultaneous inhibition of these pathways with AZD8055/2-DG combination was significantly more effective at reducing tumor volume and burden. At the molecular level, combination treatment inhibited mTORC1/mTORC2 activity, selectively inhibited mitochondria function and blocked MAPK pro-survival signaling responsible for the ERK-p90RSK feedback loop. Our findings suggest that loss of LKB1 expression be considered a marker for metabolic dysfunction given its role in regulating AMPK and mTOR function. Finally, the outcome of our pre-clinical study confirms therapies that simultaneously target mTORC1/mTORC2 and glycolytic metabolism in cancer produce the best therapeutic outcome for the treatment of patients harboring metabolically active HER2 positive breast cancers. PMID:25436981

  18. Resource Review: Youth and Adult Leaders for Program Excellence: A Practical Guide for Program Assessment and Action Planning

    Directory of Open Access Journals (Sweden)

    Hartley Hobson

    2007-03-01

    Full Text Available The Youth and Adult Leaders for Program Excellence (YALPE Resource Kit was developed to assist groups working to promote positive youth development. The Kit includes a variety of assessment tools and templates for data analysis and report writing. The tools are grounded in research on youth development and are user-friendly for adults and youth.

  19. Heuristic algorithm for single resource constrained project scheduling problem based on the dynamic programming

    Directory of Open Access Journals (Sweden)

    Stanimirović Ivan

    2009-01-01

    Full Text Available We introduce a heuristic method for the single resource constrained project scheduling problem, based on the dynamic programming solution of the knapsack problem. This method schedules projects with one type of resources, in the non-preemptive case: once started an activity is not interrupted and runs to completion. We compare the implementation of this method with well-known heuristic scheduling method, called Minimum Slack First (known also as Gray-Kidd algorithm, as well as with Microsoft Project.

  20. The geography and human cultural resources working group of the EROS program

    Science.gov (United States)

    Gerlach, A. C.

    1972-01-01

    The functions, activities, and objectives of the Geography and Human-Cultural Resources Working Group of the EROS program are outlined. The Group's primary function is to coordinate remote sensing experiments of physical scientists and the needs of socioeconomic and culturally orientated planners, policy makers, administrators, and other user groups. Other functions of the Group include land use analysis, resource mapping, and development of an operational automatic information system receptive to land use and environmental data.

  1. Allocating Resources among Prisons and Social Programs in the Battle against Crime.

    OpenAIRE

    Donohue, John J, III; Siegelman, Peter

    1998-01-01

    This article evaluates the cost and crime-reducing potential of prisons and social spending, setting forth the conditions under which a shift in resources from an expanding prison population into social spending would lead to a reduction in total crime. Preschool enrichment programs coupled with family intervention have generated impressive results in reducing crime in a number of different studies. Targeting of resources toward those children most at risk of criminal behavior is necessary to...

  2. Building Nursing and Midwifery Capacity Through Rwanda's Human Resources for Health Program.

    Science.gov (United States)

    Uwizeye, Glorieuse; Mukamana, Donatilla; Relf, Michael; Rosa, William; Kim, Mi Ja; Uwimana, Philomene; Ewing, Helen; Munyiginya, Paul; Pyburn, Renee; Lubimbi, Nanyombi; Collins, Anita; Soulé, Isabelle; Burke, Kelly; Niyokindi, Josette; Moreland, Patricia

    2017-05-01

    Global disparities in the quantity, distribution, and skills of health workers worldwide pose a threat to attainment of the Sustainable Development Goals by 2030 and deepens already existing global health inequities. Rwanda and other low-resource countries face a critical shortage of health professionals, particularly nurses and midwives. This article describes the Human Resources for Health (HRH) Program in Rwanda, a collaboration between the Ministry of Health of Rwanda and a U.S. consortium of academic institutions. The ultimate goal of the HRH Program is to strengthen health service delivery and to achieve health equity for the poor. The aim of this article is to highlight the HRH nursing and midwifery contributions to capacity building in academic and clinical educational programs throughout Rwanda. International academic partnerships need to align with the priorities of the host country, integrate the strengths of available resources, and encourage a collaborative environment of cultural humility and self-awareness for all participants.

  3. Remote sensing inputs to National Model Implementation Program for water resources quality improvement

    Science.gov (United States)

    Eidenshink, J. C.; Schmer, F. A.

    1979-01-01

    The Lake Herman watershed in southeastern South Dakota has been selected as one of seven water resources systems in the United States for involvement in the National Model Implementation Program (MIP). MIP is a pilot program initiated to illustrate the effectiveness of existing water resources quality improvement programs. The Remote Sensing Institute (RSI) at South Dakota State University has produced a computerized geographic information system for the Lake Herman watershed. All components necessary for the monitoring and evaluation process were included in the data base. The computerized data were used to produce thematic maps and tabular data for the land cover and soil classes within the watershed. These data are being utilized operationally by SCS resource personnel for planning and management purposes.

  4. The tumor suppressor gene TUSC2 (FUS1 sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner.

    Directory of Open Access Journals (Sweden)

    Jieru Meng

    Full Text Available TUSC2-defective gene expression is detected in the majority of lung cancers and is associated with worse overall survival. We analyzed the effects of TUSC2 re-expression on tumor cell sensitivity to the AKT inhibitor, MK2206, and explored their mutual signaling connections, in vitro and in vivo. TUSC2 transient expression in three LKB1-defective non-small cell lung cancer (NSCLC cell lines combined with MK2206 treatment resulted in increased repression of cell viability and colony formation, and increased apoptotic activity. In contrast, TUSC2 did not affect the response to MK2206 treatment for two LKB1-wild type NSCLC cell lines. In vivo, TUSC2 systemic delivery, by nanoparticle gene transfer, combined with MK2206 treatment markedly inhibited growth of tumors in a human LKB1-defective H322 lung cancer xenograft mouse model. Biochemical analysis showed that TUSC2 transient expression in LKB1-defective NSCLC cells significantly stimulated AMP-activated protein kinase (AMPK phosphorylation and enzymatic activity. More importantly, AMPK gene knockdown abrogated TUSC2-MK2206 cooperation, as evidenced by reduced sensitivity to the combined treatment. Together, TUSC2 re-expression and MK2206 treatment was more effective in inhibiting the phosphorylation and kinase activities of AKT and mTOR proteins than either single agent alone. In conclusion, these findings support the hypothesis that TUSC2 expression status is a biological variable that potentiates MK2206 sensitivity in LKB1-defective NSCLC cells, and identifies the AMPK/AKT/mTOR signaling axis as an important regulator of this activity.

  5. Program-oriented approach to resource saving issues in construction materials industry

    Directory of Open Access Journals (Sweden)

    Novikova Galina

    2017-01-01

    Full Text Available The construction as a sector of the economy is one of the largest consumers of energy resources, and the building materials industry is today one of the most energy-intensive construction industry. At the enterprises of the building materials industry the different approaches and methods are used to solve resource and energy problems. Energy saving is considered not as an complex approach in the enterprise activity, but as activity for the implementation of specific energy-saving projects, which have limitations in time and in resources. The authors suggest to use a softwareoriented approach to solving the problems of resource and energy saving. For practical application of program-oriented approach we offer to use a structuring method of the decision-making, not previously used to solve problems of resource and energy saving.

  6. Methods and resources for physics education in radiology residency programs: survey results.

    Science.gov (United States)

    Bresolin, Linda; Bisset, George S; Hendee, William R; Kwakwa, Francis A

    2008-11-01

    Over the past 2 years, ongoing efforts have been made to reevaluate and restructure the way physics education is provided to radiology residents. Program directors and faculty from North American radiology residency programs were surveyed about how physics is being taught and what resources are currently being used for their residents. Substantial needs were identified for additional educational resources in physics, better integration of physics into clinical training, and a standardized physics curriculum closely linked to the initial certification examination of the American Board of Radiology. (c) RSNA, 2008.

  7. US Department of Energy Integrated Resource Planning Program: Accomplishments and opportunities

    Energy Technology Data Exchange (ETDEWEB)

    White, D.L. [Oak Ridge National Lab., TN (United States); Mihlmester, P.E. [Aspen Systems Corp., Oak Ridge, TN (United States)

    1993-12-17

    The US Department of Energy Integrated Resource Planning Program supports many activities and projects that enhance the process by which utilities assess demand and supply options and, subsequently, evaluate and select resources. The US Department of Energy program coordinates integrated resource planning in risk and regulatory analysis; utility and regional planning; evaluation and verification; information transfer/technological assistance; and demand-side management. Professional staff from the National Renewable Energy Laboratory, Oak Ridge National Laboratory, Lawrence Berkeley Laboratory, and Pacific Northwest Laboratories collaborate with peers and stakeholders, in particular, the National Association of Regulatory Utility Commissioners, and conduct research and activities for the US Department of Energy. Twelve integrated resource planning activities and projects are summarized in this report. The summaries reflect the diversity of planning and research activities supported by the Department. The summaries also reflect the high levels of collaboration and teaming that are required by the Program and practiced by the researchers. It is concluded that the Program is achieving its objectives by encouraging innovation and improving planning and decision making. Furthermore, as the Department continues to implement planned improvements in the Program, the Department is effectively positioned to attain its ambitious goals.

  8. US scientific contributions to the water resources program of the International Atomic Energy Agency

    Science.gov (United States)

    Aggarwal, P. K.; Schneider, V. R.

    2007-12-01

    It is well recognized that a better understanding of the water cycle and increased availability of hydrological information for surface and groundwater resources are key factors in the ability to sustainably manage water resources. Since its inception in 1957, the International Atomic Energy Agency (IAEA) has played a critical role in developing isotope applications for hydrology and building scientific capacity in developing countries. Through an active technical cooperation program with a funding of nearly $8M per biennium, the IAEA assists developing countries in using isotope techniques for the assessment and monitoring of water resources, in particular, groundwater resources. In addition, substantial human resources and institutional capacity are built through the provision of training and appropriate equipment for monitoring. The water resources program of the IAEA is implemented with the support of a number of experts and the United States contributes extensively to this program. Although spanning the entire 50 year history of the IAEA, the contribution of US scientists, and particularly those from the US Geological Survey, has been substantial over the past 10 years. These contributions have included assistance in technical cooperation projects in Africa, Latin America and Asia, as well as internationally coordinated research projects in vadose zone hydrology, surface water - groundwater interactions, and regional aquifer studies. In Ethiopia, a national groundwater assessment program was formulated and a computer database was provided to manage hydrological information. A robust program of capacity building in cooperation with the USGS and Argonne National Laboratory has provided training to a number of IAEA-sponsored candidates from Africa and Latin America. This paper will describe the objectives and results of some of these cooperative efforts.

  9. Resource consumption of a diffusion model for prevention programs: the PROSPER delivery system.

    Science.gov (United States)

    Crowley, Daniel M; Jones, Damon E; Greenberg, Mark T; Feinberg, Mark E; Spoth, Richard L

    2012-03-01

    To prepare public systems to implement evidence-based prevention programs for adolescents, it is necessary to have accurate estimates of programs' resource consumption. When evidence-based programs are implemented through a specialized prevention delivery system, additional costs may be incurred during cultivation of the delivery infrastructure. Currently, there is limited research on the resource consumption of such delivery systems and programs. In this article, we describe the resource consumption of implementing the PROSPER (PROmoting School-Community-University Partnerships to Enhance Resilience) delivery system for a period of 5 years in one state, and how the financial and economic costs of its implementation affect local communities as well as the Cooperative Extension and University systems. We used a six-step framework for conducting cost analysis, using a Cost-Procedure-Process-Outcome Analysis model (Yates, Analyzing costs, procedures, processes, and outcomes in human services: An introduction, 1996; Yates, 2009). This method entails defining the delivery System; bounding cost parameters; identifying, quantifying, and valuing systemic resource Consumption, and conducting sensitivity analysis of the cost estimates. Our analyses estimated both the financial and economic costs of the PROSPER delivery system. Evaluation of PROSPER illustrated how costs vary over time depending on the primacy of certain activities (e.g., team development, facilitator training, program implementation). Additionally, this work describes how the PROSPER model cultivates a complex resource infrastructure and provides preliminary evidence of systemic efficiencies. This work highlights the need to study the costs of diffusion across time and broadens definitions of what is essential for successful implementation. In particular, cost analyses offer innovative methodologies for analyzing the resource needs of prevention systems. Copyright © 2012 Society for Adolescent Health and

  10. CaMKKβ is involved in AMP-activated protein kinase activation by baicalin in LKB1 deficient cell lines.

    Directory of Open Access Journals (Sweden)

    Ying Ma

    Full Text Available AMP-activated protein kinase (AMPK plays an important role in mediating energy metabolism and is controlled mainly by two upstream kinases, LKB1 or Ca(2+/calmodulin-dependent protein kinase kinase-β (CaMKKβ. Previously, we found that baicalin, one of the major flavonoids in a traditional Chinese herb medicine, Scutellaria baicalensis, protects against the development of hepatic steatosis in rats feeding with a high-fat diet by the activation of AMPK, but, the underlying mechanism for AMPK activation is unknown. Here we show that in two LKB1-deficient cells, HeLa and A549 cells, baicalin activates AMPK by α Thr-172 phosphorylation and subsequent phosphorylation of its downstream target, acetyl CoA carboxylase, at Ser-79, to a similar degree as does in HepG2 cells (that express LKB1. Pharmacologic inhibition of CaMKKβ by its selective inhibitor STO-609 markedly inhibits baicalin-induced AMPK activation in both HeLa and HepG2 cells, indicating that CaMKKβ is the responsible AMPK kinase. We also show that treatment of baicalin causes a larger increase in intracellular Ca(2+ concentration ([Ca(2+](i, although the maximal level of [Ca(2+](i is lower in HepG2 cells compared to HeLa cells. Chelation of intracellular free Ca(2+ by EDTA and EGTA, or depletion of intracellular Ca(2+ stores by the endoplasmic reticulum Ca(2+-ATPase inhibitor thapsigargin abrogates baicalin-induced activation of AMPK in HeLa cells. Neither cellular ATP nor the production of reactive oxygen species is altered by baicalin. Finally, in HeLa cells, baicalin treatment no longer decreases intracellular lipid accumulation caused by oleic acid after inhibition of CaMKKβ by STO-609. These results demonstrate that a potential Ca(2+/CaMKKβ dependent pathway is involved in the activation of AMPK by baicalin and suggest that CaMKKβ likely acts as an upstream kinase of AMPK in response to baicalin.

  11. Unique program aims to connect frequent ED utilizers with medical homes, resources to meet complex needs.

    Science.gov (United States)

    2014-10-01

    Sinai Hospital of Baltimore in Baltimore, MD, is partnering with HealthCare Access Maryland, a non-profit organization in the state, to link patients who frequent the ED for care with medical homes and other resources that can better meet their medical and social needs. Under the Access Health Program, ED-based care coordinators intervene with patients who meet program criteria, linking them with medical homes and other resources that address their complex needs. The hospital has devised a flag to notify the ED when a frequent-utilizing patient presents in the department for care. Care coordinators then meet with these patients and get their consent to participate in the program. Within a week of the ED visit, care coordinators schedule a home visit with the patient to establish a care plan containing specific goals and a time frame to carry out these goals. Patients remain in the program for 90 days as care coordinators work to hand them off to longer-term resources. Many of the patients enrolled in the program have substance abuse and mental health problems. Patients are also often uninsured and/or homeless. Within two months of launching the program, care coordinators enrolled 74 patients, with the goal of eventually bringing that number to 200.

  12. Natural Resources Research Program: Catalog of Computer Programs for Project Management.

    Science.gov (United States)

    project management . These include programs developed for use on a microcomputer, as well as those which run on a host computer but are accessed by a terminal in a field office. A one-page description of each program contains the title; preparing agency; abstract; a summary of the data inputs and outputs; equipment, disk, and memory requirements; operating system and programming language; and a contact for further information. The programs described in this publication are not limited to those available within the Corps, but also include those available from other

  13. Citizen science and natural resource governance: program design for vernal pool policy innovation

    Directory of Open Access Journals (Sweden)

    Bridie McGreavy

    2016-06-01

    Full Text Available Effective natural resource policy depends on knowing what is needed to sustain a resource and building the capacity to identify, develop, and implement flexible policies. This retrospective case study applies resilience concepts to a 16-year citizen science program and vernal pool regulatory development process in Maine, USA. We describe how citizen science improved adaptive capacities for innovative and effective policies to regulate vernal pools. We identified two core program elements that allowed people to act within narrow windows of opportunity for policy transformation, including (1 the simultaneous generation of useful, credible scientific knowledge and construction of networks among diverse institutions, and (2 the formation of diverse leadership that promoted individual and collective abilities to identify problems and propose policy solutions. If citizen science program leaders want to promote social-ecological systems resilience and natural resource policies as outcomes, we recommend they create a system for internal project evaluation, publish scientific studies using citizen science data, pursue resources for program sustainability, and plan for leadership diversity and informal networks to foster adaptive governance.

  14. Open Educational Resources: A Review of Attributes for Adoption in an Online Bachelor's Degree Program

    Science.gov (United States)

    Neely, Patricia; Tucker, Jan P.; Au, Angela

    2016-01-01

    As concerns about the skyrocketing costs of a college degree have converged with the increasing availability of open educational resources (OER), higher education administrators are asking faculty and curriculum designers to use OERs to design courses and programs. This case study explores the decision making process and outcomes of an online,…

  15. A Guide for Planning Post-Secondary Programs for Agribusiness, Natural Resources, and Environmental Protection Occupations.

    Science.gov (United States)

    Beasley, Gary F.

    This publication is intended to provide a reference for teachers, counselors, and administrators in planning, administering and conducting vocational and technical programs in agribusiness, natural resources and environmental protection at the postsecondary level. The material is presented in sections, each with a list of selected references, as…

  16. Demonstrating the value of a social science research program to a natural resource management agency

    Science.gov (United States)

    Pamela J. Jakes; John F. Dwyer; Deborah S. Carr

    1998-01-01

    With ever tightening resources to address an increased number of diverse and complex issues, it has become common for scientists and managers to be called upon to demonstrate the value of their programs. In the spring of 1995, social scientists at the USDA Forest Service North Central Forest Experiment Station we so called upon. This paper discusses an effort to...

  17. A Critical Evaluation on Programming Paradigms to Achieve Optimal Resource Utilization of Mobile Softwares in Mobile Devices

    OpenAIRE

    Selvakumar Samuel; Arangasamy Kovalan

    2014-01-01

    This paper evaluates the features of mainstream programming paradigms. Imperative, object oriented programming and functional programming concepts are considered here. This is an effort to identify the programming paradigms which consume less resource from mobile devices. Designers usually depend on the programming languages, language oriented programming design is in current practice. Choosing appropriate programming paradigms during the mobile application design is not in practice now; Fail...

  18. Annual review of cultural resource investigations by the Savannah River Archaeological Research Program. Fiscal year 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-10-01

    The Savannah River Archaeological Research Program (SRARP) of the South Carolina Institute of Archaeology and Anthropology, University of South Carolina, manages archaeological resources on the Savannah River Site (SRS). An ongoing research program provides the theoretical, methodological, and empirical basis for assessing site significance within the compliance process specified by law. The SRARP maintains an active public education program for disseminating knowledge about prehistory and history, and for enhancing awareness of historic preservation. This report summarizes the management, research, and public education activities of the SRARP during Fiscal Year 1994.

  19. Resources.

    Science.gov (United States)

    Stewart, John; MacDonald, Ian

    1980-01-01

    Presents a guide to resources on television drama available to teachers for classroom use in television curriculum. Lists American and British television drama videorecordings of both series and individual presentations and offers a bibliography of "one-off" single fiction plays produced for British television. (JMF)

  20. Inexact Multistage Stochastic Chance Constrained Programming Model for Water Resources Management under Uncertainties

    Directory of Open Access Journals (Sweden)

    Hong Zhang

    2017-01-01

    Full Text Available In order to formulate water allocation schemes under uncertainties in the water resources management systems, an inexact multistage stochastic chance constrained programming (IMSCCP model is proposed. The model integrates stochastic chance constrained programming, multistage stochastic programming, and inexact stochastic programming within a general optimization framework to handle the uncertainties occurring in both constraints and objective. These uncertainties are expressed as probability distributions, interval with multiply distributed stochastic boundaries, dynamic features of the long-term water allocation plans, and so on. Compared with the existing inexact multistage stochastic programming, the IMSCCP can be used to assess more system risks and handle more complicated uncertainties in water resources management systems. The IMSCCP model is applied to a hypothetical case study of water resources management. In order to construct an approximate solution for the model, a hybrid algorithm, which incorporates stochastic simulation, back propagation neural network, and genetic algorithm, is proposed. The results show that the optimal value represents the maximal net system benefit achieved with a given confidence level under chance constraints, and the solutions provide optimal water allocation schemes to multiple users over a multiperiod planning horizon.

  1. Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats.

    Science.gov (United States)

    Jiang, Shu-Jun; Dong, Hui; Li, Jing-Bin; Xu, Li-Jun; Zou, Xin; Wang, Kai-Fu; Lu, Fu-Er; Yi, Ping

    2015-07-07

    To investigate the molecular mechanisms of berberine inhibition of hepatic gluconeogenesis in a diabetic rat model. The 40 rats were randomly divided into five groups. One group was selected as the normal group. In the remaining groups (n = 8 each), the rats were fed on a high-fat diet for 1 mo and received intravenous injection of streptozotocin for induction of the diabetic models. Berberine (156 mg/kg per day) (berberine group) or metformin (184 mg/kg per day) (metformin group) was intragastrically administered to the diabetic rats and 5-aminoimidazole-4-carboxamide1-β-D-ribofuranoside (AICAR) (0.5 mg/kg per day) (AICAR group) was subcutaneously injected to the diabetic rats for 12 wk. The remaining eight diabetic rats served as the model group. Fasting plasma glucose and insulin levels as well as lipid profile were tested. The expressions of proteins were examined by western blotting. The nuclear translocation of CREB-regulated transcription co-activator (TORC)2 was observed by immunohistochemical staining. Berberine improved impaired glucose tolerance and decreased plasma hyperlipidemia. Moreover, berberine decreased fasting plasma insulin and homeostasis model assessment of insulin resistance (HOMA-IR). Berberine upregulated protein expression of liver kinase (LK)B1, AMP-activated protein kinase (AMPK) and phosphorylated AMPK (p-AMPK). The level of phophorylated TORC2 (p-TORC2) protein in the cytoplasm was higher in the berberine group than in the model group, and no significant difference in total TORC2 protein level was observed. Immunohistochemical staining revealed that more TORC2 was localized in the cytoplasm of the berberine group than in the model group. Moreover, berberine treatment downregulated protein expression of the key gluconeogenic enzymes (phosphoenolpyruvate carboxykinase and glucose-6-phosphatase) in the liver tissues. Our findings revealed that berberine inhibited hepatic gluconeogenesis via the regulation of the LKB1-AMPK-TORC2

  2. Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism

    Science.gov (United States)

    Sid, Victoria; Wu, Nan; Sarna, Lindsei K.; Siow, Yaw L.; House, James D.

    2015-01-01

    AMPK is an endogenous energy sensor that regulates lipid and carbohydrate metabolism. Nonalcoholic fatty liver disease (NAFLD) is regarded as a hepatic manifestation of metabolic syndrome with impaired lipid and glucose metabolism and increased oxidative stress. Our recent study showed that folic acid supplementation attenuated hepatic oxidative stress and lipid accumulation in high-fat diet-fed mice. The aim of the present study was to investigate the effect of folic acid on hepatic AMPK during high-fat diet feeding and the mechanisms involved. Male C57BL/6J mice were fed a control diet (10% kcal fat), a high-fat diet (60% kcal fat), or a high-fat diet supplemented with folic acid (26 mg/kg diet) for 5 wk. Mice fed a high-fat diet exhibited hyperglycemia, hepatic cholesterol accumulation, and reduced hepatic AMPK phosphorylation. Folic acid supplementation restored AMPK phosphorylation (activation) and reduced blood glucose and hepatic cholesterol levels. Activation of AMPK by folic acid was mediated through an elevation of its allosteric activator AMP and activation of its upstream kinase, namely, liver kinase B1 (LKB1) in the liver. Consistent with in vivo findings, 5-methyltetrahydrofolate (bioactive form of folate) restored phosphorylation (activation) of both AMPK and LKB1 in palmitic acid-treated HepG2 cells. Activation of AMPK by folic acid might be responsible for AMPK-dependent phosphorylation of HMG-CoA reductase, leading to reduced hepatic cholesterol synthesis during high-fat diet feeding. These results suggest that folic acid supplementation may improve cholesterol and glucose metabolism by restoration of AMPK activation in the liver. PMID:26400185

  3. Annual review of cultural resource investigations by the Savannah River Archaeological Research Program. Fiscal year 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-01

    A cooperative agreement with the United States Department of Energy provides the necessary funding for the Savannah River Archaeological Research Program (SRARP) of the South Carolina Institute of Archaeology and Anthropology, University of South Carolina, to render services required under federal law for the protection and management of archaeological resources on the Savannah River Site (SRS). Because the significance of archaeological resources is usually determined by research potential, the SRARP is guided by research objectives. An ongoing research program provides the theoretical, methodological, and empirical basis for assessing site significance within the compliance process specified by law. In accordance with the spirit of the law, the SRARP maintains an active public education program for disseminating knowledge about prehistory and history, and for enhancing awareness of historic preservation. This report summarizes the management, research, and public education activities of the SRARP during Fiscal Year 1993.

  4. Annual review of cultural resource investigations by the Savannah River Archaeological Research Program: Fiscal year 1991

    Energy Technology Data Exchange (ETDEWEB)

    Brooks, Mark J.; Brooks, Richard D.; Sassaman, Kenneth E.; Crass, David C.; Stephenson, D. Keith; Green, William; Rinehart, Charles J.; Lewis, George S.; Fuglseth, Ty; Krawczynski, Keith; Warnock, D. Mark

    1991-10-01

    A cooperative agreement with the United States Department of Energy provides the necessary funding for the Savannah River Archaeological Research Program (SRARP) of the South Carolina Institute of Archaeology and Anthropology, University of South Carolina, to render services required under federal law for the protection and management of archaeological resources on the Savannah River Site (SRS). Because the significance of archaeological resources is usually determined by research potential, the SRARP is guided by research objectives. An ongoing research program provides the theoretical, methodological and empirical basis for assessing site significance within the compliance process specified by law. In accordance with the spirit of the law, the SRARP maintains an active public education program for disseminating knowledge about prehistory and history, and for enhancing awareness of historic preservation. This report summarizes the management, research and public education activities of the SRARP during Fiscal Year 1991.

  5. Annual review of cultural resource investigations by the Savannah River Archaeological Research Program, fiscal year 1990

    Energy Technology Data Exchange (ETDEWEB)

    Brooks, Mark J.; Brooks, Richard D.; Sassaman, Kenneth E.; Crass, David C.; Lewis, George S.; Stephenson, D. Keith; Green, William; Anderson, David G.; Fuglseth, Ty

    1990-11-01

    The Savannah River Archaeological Research Program (SRARP) of the South Carolina Institute of Archaeology and Anthropology, University of South Carolina, is funded through a direct contract with the United States Department of Energy to provide services required under federal law for the protection and management of archaeological resources on the Savannah River Site (SRS). Because the significance of most archaeological resources is dependent upon research potential, the SRARP is guided by research objectives. An on-going research program provides the problems, methods and means of assessing site significance within the compliance process specified by law. In addition, the SRARP maintains an active program of public education to disseminate knowledge about prehistory and history, and to enhance public awareness about historic preservation. The following report summarizes the management, research and public education activities of the SRARP during Fiscal Year 1990.

  6. Environmental Impact Research Program and Defense Natural Resources Program: Section 7. 5. 7, US Army Corps of Engineers Wildlife Resources Management manual. Final report. [ELAEAGNUS UMBELLATA

    Energy Technology Data Exchange (ETDEWEB)

    Dittberner, P.L.; Dietz, D.R.; Wasser, C.H.; Martin, C.O.; Mitchell, W.A.

    1992-02-01

    A plant materials report on autumn olive (Elaeagnus umbellata) is provided as Section 7.5.7 of the US Army Corps of Engineers Wildlife Resources management Manual. The report was prepared as a guide to assist project/installation natural resources personnel with the selection, establishment, and management of appropriate plant materials for wildlife and habitat development programs. Major topics covered are description, distribution, habitat requirements, wildlife and land management value, establishment, maintenance, and cautions and limitations. Autumn olive is a hardy shrub or small tree introduced into the United States from Asia. It is widely used in the East in habitat improvement projects designed to attract wildlife, provide barriers, beautify existing landscapes, and reclaim disturbed sites. Autumn olive is tolerant of a wide range of soils and climatic conditions. Plants grow best on well-drained soils that are deep, sandy, loamy, or moderately fine-textured. Establishment of autumn olive is often recommended for borders, hedgerows, windbreaks, and disturbed sites. Planting stock of autumn olive is readily available, and some commercial nurseries produce propagules in quantity. Four cultivars (Cardinal, Ellagood, Elsberry, and Redwing) have been developed and are adapted to geographically specific regions. This report provides information on management objectives, site selection and preparation, propagule selection, planting methods, and maintenance requirements for autumn olive throughout its area of potential use. Management cautions and limitations are discussed, and guidelines are provided on the appropriate use of autumn olive in wildlife and habitat management programs.

  7. Outside the operating room: How a robotics program changed resource utilization on the inpatient Ward.

    Science.gov (United States)

    Leung, Annie; Abitbol, Jeremie; Ramana-Kumar, Agnihotram V; Fadlallah, Bassam; Kessous, Roy; Cohen, Sabine; Lau, Susie; Salvador, Shannon; Gotlieb, Walter H

    2017-04-01

    To analyze the changes in the composition of the gynecologic oncology inpatient ward following the implementation of a robotic surgery program and its impact on inpatient resource utilization and costs. Retrospective review of the medical charts of patients admitted onto the gynecologic oncology ward the year prior to and five years after the implementation of robotics. The following variables were collected: patient characteristics, hospitalization details (reason for admission and length of hospital stay), and resource utilization (number of hospitalization days, consultations, and imaging). Following the introduction of robotic surgery, there were more admissions for elective surgery yet these accounted for only 21% of the inpatient ward in terms of number of hospital days, compared to 36% prior to the robotic program. This coincided with a sharp increase in the overall number of patients operated on by a minimally invasive approach (15% to 76%, probotics era. The robotics program contributed to a ward with higher proportion of patients with complex comorbidities (Charlson≥5: RR 1.06), Stage IV disease (RR 1.30), and recurrent disease (RR 1.99). Introduction of robotic surgery allowed for more patients to be treated surgically while simultaneously decreasing inpatient resource use. With more patients with non-surgical oncological issues and greater medical complexity, the gynecologic oncology ward functions more like a medical rather than surgical ward after the introduction of robotics, which has implications for hospital-wide resource planning. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Migrant Nurses and Federal Caregiver Programs in Canada: Migration and Health Human Resources Paradox.

    Science.gov (United States)

    Salami, Bukola

    2016-06-01

    Despite the links between health human resources policy, immigration policy, and education policy, silos persist in the policy-making process that complicate the professional integration of internationally educated nurses in Canada. Drawing on the literature on nurse migration to Canada through the Live-in Caregiver Program, this paper sheds light on the contradictions between immigration and health human resources policy and their effect on the integration of internationally educated nurses in Canada. The analysis reveals a series of paradoxes within and across immigration and health human resources policy that affect the process of professional integration of this group of health professionals into the nursing workforce in Canada. I will further link the discussion to the recently implemented Caregiver Program, which provides a unique pathway for healthcare workers, including nurses, to migrate to Canada. Given recent introduction of the Canadian Caregiver Program, major policy implications include the need to bridge the gap between health human resources policy and immigration policy to ensure the maximum integration of migrant nurses in Canada.

  9. Hawaii energy strategy project 3: Renewable energy resource assessment and development program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-11-01

    RLA Consulting (RLA) has been retained by the State of Hawaii Department of Business, Economic Development and Tourism (DBEDT) to conduct a Renewable Energy Resource Assessment and Development Program. This three-phase program is part of the Hawaii Energy Strategy (HES), which is a multi-faceted program intended to produce an integrated energy strategy for the State of Hawaii. The purpose of Phase 1 of the project, Development of a Renewable Energy Resource Assessment Plan, is to better define the most promising potential renewable energy projects and to establish the most suitable locations for project development in the state. In order to accomplish this goal, RLA has identified constraints and requirements for renewable energy projects from six different renewable energy resources: wind, solar, biomass, hydro, wave, and ocean thermal. These criteria were applied to areas with sufficient resource for commercial development and the results of Phase 1 are lists of projects with the most promising development potential for each of the technologies under consideration. Consideration of geothermal energy was added to this investigation under a separate contract with DBEDT. In addition to the project lists, a monitoring plan was developed with recommended locations and a data collection methodology for obtaining additional wind and solar data. This report summarizes the results of Phase 1. 11 figs., 22 tabs.

  10. A LINEAR PROGRAMMING METHOD TO ENHANCE RESOURCE UTILIZATION CASE OF ETHIOPIAN APPAREL SECTOR

    Directory of Open Access Journals (Sweden)

    Gezahegn Tesfaye

    2016-06-01

    Full Text Available The Ethiopian industrial development strategy is characterized by export-led and labor intensive industrialization. The country is emerging as the most important investment destination in its apparel sector. Thought this sector is expected to generate more income from the export market, its export earnings remain trivial mainly due to the inefficient organizational resource utilization. One of the competent techniques that help companies to efficiently improve the use of their resources to increase their profit is linear programming. In apparel manufacturing firms, efficient use of materials such as fabrics and sewing threads and processing time at different stages of production as well as minimization of labor and materials cost are necessary to enhance their profitability. Cutting, sewing, and finishing operations deserve more attention for apparel process optimization. However, the issue of proper resource allocation remains an unsolved problem within the Ethiopian apparel industry. The aim of this research is to devise efficient resource utilization mechanism for Ethiopian apparel sector to improve their resource utilization and profitability, taking one of the garment factories engaged in the export market as a case study. Five types of products the company is currently producing, the amount of resources employed to produce each unit of the products, and the value of profit per unit from the sale of each products have been collected from the case company. The monthly availability of resources utilized and the monthly production volume of the five products have also been collected from the company. The data gathered was mathematically modeled using a linear programming technique, and solved using MS-Excel solver. The findings of the study depicts that all of the organizational resources are severely underutilized. This research proved that the resource utilization of the case company can be improved from 46.41% of the current resource

  11. Resource Allocation Optimization Model of Collaborative Logistics Network Based on Bilevel Programming

    Directory of Open Access Journals (Sweden)

    Xiao-feng Xu

    2017-01-01

    Full Text Available Collaborative logistics network resource allocation can effectively meet the needs of customers. It can realize the overall benefit maximization of the logistics network and ensure that collaborative logistics network runs orderly at the time of creating value. Therefore, this article is based on the relationship of collaborative logistics network supplier, the transit warehouse, and sellers, and we consider the uncertainty of time to establish a bilevel programming model with random constraints and propose a genetic simulated annealing hybrid intelligent algorithm to solve it. Numerical example shows that the method has stronger robustness and convergence; it can achieve collaborative logistics network resource allocation rationalization and optimization.

  12. ERTS program of the US Army Corps of Engineers. [water resources

    Science.gov (United States)

    Jarman, J. W.

    1974-01-01

    The Army Corps of Engineers research and development efforts associated with the ERTS Program are confined to applications of investigation, design, construction, operation, and maintenance of water resource projects. Problems investigated covered: (1) resource inventory; (2) environmental impact; (3) pollution monitoring; (4) water circulation; (5) sediment transport; (6) data collection systems; (7) engineering; and (8) model verification. These problem areas were investigated in relation to bays, reservoirs, lakes, rivers, coasts, and regions. ERTS-1 imagery has been extremely valuable in developing techniques and is now being used in everyday applications.

  13. NGSS aligned Earth science resources and professional development programs from the Exploratorium.

    Science.gov (United States)

    Muller, E.

    2016-12-01

    The Exploratorium is a museum of science, art and human perception located in San Francisco, CA. The Exploratorium has been offering resources and professional development to primary and secondary teachers since 1972. We focus on inquiry based, hands-on learning, with an emphasis on Next Generation Science Standards (NGSS) implementation. This brief, invited presentation will feature the programs and online resources developed by the Exploratorium's "Institute for Inquiry" and "Teacher Institute" that may help formal and informal educators engage, implement and promote three dimensional learning in the Earth Sciences.

  14. Program accomplishments and future prospects for low-temperature geothermal resource assessment in New Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Icerman, L.; Ruscetta, C.A. (ed.)

    1982-07-01

    An important component of the State-coupled program has been basic studies in specific regions of New Mexico, including areas adjacent to the cities of Albuquerque, Las Cruces, Socorro, and Truth or Consequences. Considerable geological, hydrological, electrical resistivity, gravity, magnetic, seismic, water analysis, and subsurface temperature data have been compiled and analyzed for these locations. During the four-year research program, a total of 25 tasks have been undertaken. Eleven of these tasks were focused toward collecting and compiling statewide data, six were regional studies covering more than one county, and eight were research projects directed primarily toward data collection near specific cities or known resource areas. Two of these latter studies contributed significantly to the confirmation of the Las Alturas geothermal anomaly east of Las Cruces. A brief summary of the program accomplishments by task is presented. The resource assessment programs in New Mexico have been very successful in (1) delineating low-temperature geothermal resources throughout New Mexico on statewide, regional, and area-specific scales; (2) developing a strong community of in-state geothermal energy research and development professionals and practitioners; and (3) elevating the level of awareness of geothermal energy potential among commerce, industry, and the general public. Future prospects for the state are presented.

  15. Use of Online Information Resources by RMIT University Economics, Finance, and Marketing Students Participating in a Cooperative Education Program

    Science.gov (United States)

    Costa, Cathy

    2009-01-01

    This paper examines the use of online information resources by Economics, Finance, and Marketing 3rd year students in a cooperative education program and explores some possible factors and issues that influence how students use these resources. The nature of Work Integrated Learning (WIL) programs, the business information environment, and the…

  16. "Superheroes in the Resource Room": A Study Examining Implementation of the Superhero Social Skills Program by a Resource Teacher with Students with Externalizing Behavior Problems

    Science.gov (United States)

    Springer, Benjamin James

    2012-01-01

    The current study evaluated the effectiveness of the Superhero Social Skills program in increasing the social engagement skills and decreasing the aggressive behavior of students with externalizing behavior problems as implemented by a resource teacher. There have been no empirical evaluations of the Superhero Social Skills program as implemented…

  17. Valuation of selected environmental impacts associated with Bonneville Power Administration Resource Program alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Englin, J E; Gygi, K F

    1992-03-01

    This report documents work undertaken by the Pacific Northwest Laboratory (PNL) and its contractors to assist the Bonneville Power Administration (Bonneville) in assessing the potential environmental consequences of new power resources. A major purpose of this effort is to describe and evaluate the techniques available for economic valuation of environmental costs. Another is to provide estimates of the environmental costs associated with specific power resources called for under Bonneville's Resource Programs. Bonneville's efforts to extend valuation techniques to as many impacts as can be reliably assessed represents a substantial advance in the application of state-of-the-art economic techniques to environmental assessments. This economic analysis evaluates effects on human health, wildlife, crops, and visibility impacts associated with air pollution. This report also discusses river recreation (primarily fishing) which may be affected by fluctuations in water levels. 70 refs.

  18. USGS Mineral Resources Program; national maps and datasets for research and land planning

    Science.gov (United States)

    Nicholson, S.W.; Stoeser, D.B.; Ludington, S.D.; Wilson, Frederic H.

    2001-01-01

    The U.S. Geological Survey, the Nation’s leader in producing and maintaining earth science data, serves as an advisor to Congress, the Department of the Interior, and many other Federal and State agencies. Nationwide datasets that are easily available and of high quality are critical for addressing a wide range of land-planning, resource, and environmental issues. Four types of digital databases (geological, geophysical, geochemical, and mineral occurrence) are being compiled and upgraded by the Mineral Resources Program on regional and national scales to meet these needs. Where existing data are incomplete, new data are being collected to ensure national coverage. Maps and analyses produced from these databases provide basic information essential for mineral resource assessments and environmental studies, as well as fundamental information for regional and national land-use studies. Maps and analyses produced from the databases are instrumental to ongoing basic research, such as the identification of mineral deposit origins, determination of regional background values of chemical elements with known environmental impact, and study of the relationships between toxic elements or mining practices to human health. As datasets are completed or revised, the information is made available through a variety of media, including the Internet. Much of the available information is the result of cooperative activities with State and other Federal agencies. The upgraded Mineral Resources Program datasets make geologic, geophysical, geochemical, and mineral occurrence information at the state, regional, and national scales available to members of Congress, State and Federal government agencies, researchers in academia, and the general public. The status of the Mineral Resources Program datasets is outlined below.

  19. An Inventory-Theory-Based Inexact Multistage Stochastic Programming Model for Water Resources Management

    Directory of Open Access Journals (Sweden)

    M. Q. Suo

    2013-01-01

    Full Text Available An inventory-theory-based inexact multistage stochastic programming (IB-IMSP method is developed for planning water resources systems under uncertainty. The IB-IMSP is based on inexact multistage stochastic programming and inventory theory. The IB-IMSP cannot only effectively handle system uncertainties represented as probability density functions and discrete intervals but also efficiently reflect dynamic features of system conditions under different flow levels within a multistage context. Moreover, it can provide reasonable transferring schemes (i.e., the amount and batch of transferring as well as the corresponding transferring period associated with various flow scenarios for solving water shortage problems. The applicability of the proposed IB-IMSP is demonstrated by a case study of planning water resources management. The solutions obtained are helpful for decision makers in not only identifying different transferring schemes when the promised water is not met, but also making decisions of water allocation associated with different economic objectives.

  20. The scope of the Weatherization Assistance Program: The weatherized population and the resource base

    Energy Technology Data Exchange (ETDEWEB)

    Power, M.; Eisenberg, J.F.; Michels, E. (Economic Opportunity Research Inst., Washington, DC (United States)); Witherspoon, M.J. (National Association for State Community Service Programs, Washington, DC (United States)); Brown, M.A. (Oak Ridge National Lab., TN (United States))

    1992-05-01

    This study is one of five parts of the US Department of Energy's national evaluation of its Weatherization Assistance Program (WAP). It has three major goals: (1) to enumerate the size and sources of investment in low-income weatherization; (2) to provide a count of the number of low-income units weatherized by all weatherization programs and characterized the type and tenure of those homes; and (3) to document the extent to which the DOE/WAP funding has been expanded though use of external resources.

  1. The scope of the Weatherization Assistance Program: The weatherized population and the resource base

    Energy Technology Data Exchange (ETDEWEB)

    Power, M.; Eisenberg, J.F.; Michels, E. [Economic Opportunity Research Inst., Washington, DC (United States); Witherspoon, M.J. [National Association for State Community Service Programs, Washington, DC (United States); Brown, M.A. [Oak Ridge National Lab., TN (United States)

    1992-05-01

    This study is one of five parts of the US Department of Energy`s national evaluation of its Weatherization Assistance Program (WAP). It has three major goals: (1) to enumerate the size and sources of investment in low-income weatherization; (2) to provide a count of the number of low-income units weatherized by all weatherization programs and characterized the type and tenure of those homes; and (3) to document the extent to which the DOE/WAP funding has been expanded though use of external resources.

  2. Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.

    Science.gov (United States)

    Cheng, Xinlai; Kim, Jee Young; Ghafoory, Shahrouz; Duvaci, Tijen; Rafiee, Roya; Theobald, Jannick; Alborzinia, Hamed; Holenya, Pavlo; Fredebohm, Johannes; Merz, Karl-Heinz; Mehrabi, Arianeb; Hafezi, Mohammadreza; Saffari, Arash; Eisenbrand, Gerhard; Hoheisel, Jörg D; Wölfl, Stefan

    2016-06-01

    Pancreatic ductal adenocarcinoma (PDAC) clinically has a very poor prognosis. No small molecule is available to reliably achieve cures. Meisoindigo is chemically related to the natural product indirubin and showed substantial efficiency in clinical chemotherapy for CML in China. However, its effect on PDAC is still unknown. Our results showed strong anti-proliferation effect of meisoindigo on gemcitabine-resistant PDACs. Using a recently established primary PDAC cell line, called Jopaca-1 with a larger CSCs population as model, we observed a reduction of CD133+ and ESA+/CD44+/CD24+ populations upon treatment and concomitantly a decreased expression of CSC-associated genes, and reduced cellular mobility and sphere formation. Investigating basic cellular metabolic responses, we detected lower oxygen consumption and glucose uptake, while intracellular ROS levels increased. This was effectively neutralized by the addition of antioxidants, indicating an essential role of the cellular redox balance. Further analysis on energy metabolism related signaling revealed that meisoindigo inhibited LKB1, but activated AMPK. Both of them were involved in cellular apoptosis. Additional in situ hybridization in tissue sections of PDAC patients reproducibly demonstrated co-expression and -localization of LKB1 and CD133 in malignant areas. Finally, we detected that CD133+/CD44+ were more vulnerable to meisoindigo, which could be mimicked by LKB1 siRNAs. Our results provide the first evidence, to our knowledge, that LKB1 sustains the CSC population in PDACs and demonstrate a clear benefit of meisoindigo in treatment of gemcitabine-resistant cells. This novel mechanism may provide a promising new treatment option for PDAC. Copyright © 2016 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  3. Evaluation of the Waste Tire Resources Recovery Program and Environmental Health Policy in Taiwan

    OpenAIRE

    Chen, Chia-Ching; Yamada, Tetsuji; Chiu, I-Ming; Liu, Yi-Kuen

    2009-01-01

    This paper examines the effectiveness of Taiwanese environmental health policies, whose aim is to improve environmental quality by reducing tire waste via the Tire Resource Recovery Program. The results confirm that implemented environmental health policies improve the overall health of the population (i.e. a decrease in death caused by bronchitis and other respiratory diseases). Current policy expenditures are far below the optimal level, as it is estimated that a ten percent increase in the...

  4. Communicating vaccine safety in the context of immunization programs in low resource settings.

    Science.gov (United States)

    Arwanire, Edison M; Mbabazi, William; Mugyenyi, Possy

    2015-01-01

    Vaccines are effective in preventing infectious diseases and their complications, hence reducing morbidity and infectious disease mortaity. Successful immunization programs, however, depend on high vaccine acceptance and coverage rates. In recent years there has been an increased level of public concern towards real or perceived adverse events associated with immunizations, leading to many people in high- as well as low-resource settings to refuse vaccines. Health care workers therefore must be able to provide parents and guardians of children with the most current and accurate information about the benefits and risks of vaccination. Communicating vaccine safety using appropriate channels plays a crucial role in maintaining public trust and confidence in vaccination programs. Several factors render this endeavor especially challenging in low-resource settings where literacy rates are low and access to information is often limited. Many languages are spoken in most countries in low-resource settings, making the provision of appropriate information difficult. Poor infrastructure often results in inadequate logistics. Recently, some concerned consumer groups have been able to propagate misinformation and rumors. To successfully communicate vaccine safety in a resource limited setting it is crucial to use a mix of communication channels that are both culturally acceptable and effective. Social mobilization through cultural, administrative and political leaders, the media or text messages (SMS) as well as the adoption of the Village Health Team (VHT) strategy whereby trained community members (Community Health Workers (CHWs)) are providing primary healthcare, can all be effective in increasing the demand for immunization.

  5. Wind resource assessment handbook: Fundamentals for conducting a successful monitoring program

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, B.H.; McDonald, S.L.; Bernadett, D.W.; Markus, M.J.; Elsholz, K.V. [AWS Scientific, Inc., Albany, NY (US)

    1997-04-01

    This handbook presents industry-accepted guidelines for planning and conducting a wind resource measurement program to support a wind energy feasibility initiative. These guidelines, which are detailed and highly technical, emphasize the tasks of selecting, installing, and operating wind measurement equipment, as well as collecting and analyzing the associated data, once one or more measurement sites are located. The handbook's scope encompasses state-of-the-art measurement and analysis techniques at multiple heights on tall towers (e.g., 40 m) for a measurement duration of at least one year. These guidelines do not represent every possible method of conducting a quality wind measurement program, but they address the most important elements based on field-proven experience. The intended audience for this handbook is any organization or individual who desires the planning framework and detailed procedures for conducting a formally structured wind measurement program. Personnel from the management level to field technicians will find this material applicable. The organizational aspects of a measurement program, including the setting of clear program objectives and designing commensurate measurement and quality assurance plans, all of which are essential to ensuring the program's successful outcome, are emphasized. Considerable attention is also given to the details of actually conducting the measurement program in its many aspects, from selecting instrumentation that meets minimum performance standards to analyzing and reporting on the collected data. 5 figs., 15 tabs.

  6. System of Budget Planning, Programming, Development and Execution and the Defence Resources Management Model (DRMM

    Directory of Open Access Journals (Sweden)

    Davor Čutić

    2010-07-01

    Full Text Available The system of budget planning, programming, development and execution of the Ministry of Defence of the Republic of Croatia (henceforth: the Croatian acronym SPPIIP is the basic system for the strategic management of defence resources through which an effective and rational distribution of available resources is conducted, based on the goals of national security of the Republic of Croatia. This system sets the principles of transparency and democratic management of defence resources while respecting the specificities of the defence system. The SPPIIP allows for decision making based on complete information about alternatives and the choice of the most economical and most efficient way to reach the goal. It unites the strategic plan, program and budget. It consists of four continuous, independent and interconnected phases: planning, programming, development and the execution of the budget. The processes of the phases are dynamic and cyclic. In addition to the SPPIIP, the Defence Resources Management Model (DRMM, Croatian acronym: MURO has also been developed. This is an analytic tool which serves as a decision support system in the SPPIIP. The DRMM is a complex computer model showing graph and tabular overviews in a multi-year period. The model examines three areas: the strength of the forces, expenses and defence programs. The purpose of the model is cost and strength analysis and the analysis of compromise and feasibility, i.e. how sensitive the programs are to fiscal movements in the sphere of the MoD budget in the course of a multiyear cycle, until a certain project ends. The analysis results are an easily understandable basis for decision making. The SPPIIP and the DRMM are mutually independent systems, but they complement each other well. The SPPIIP uses the DRMM in designing and resource allocation based on the goals set. The quality of the DRMM depends on the amount and quality of data in its database. The DRMM can be used as a basis for

  7. State Electricity Regulatory Policy and Distributed Resources: Distributed Resource Distribution Credit Pilot Programs--Revealing the Value to Consumers and Vendors

    Energy Technology Data Exchange (ETDEWEB)

    Moskovitz, D.; Harrington, C.; Shirley, W.; Cowart, R.; Sedano, R.; Weston, F.

    2002-10-01

    Designing and implementing credit-based pilot programs for distributed resources distribution is a low-cost, low-risk opportunity to find out how these resources can help defer or avoid costly electric power system (utility grid) distribution upgrades. This report describes implementation options for deaveraged distribution credits and distributed resource development zones. Developing workable programs implementing these policies can dramatically increase the deployment of distributed resources in ways that benefit distributed resource vendors, users, and distribution utilities. This report is one in the State Electricity Regulatory Policy and Distributed Resources series developed under contract to NREL (see Annual Technical Status Report of the Regulatory Assistance Project: September 2000-September 2001, NREL/SR-560-32733). Other titles in this series are: (1) Accommodating Distributed Resources in Wholesale Markets, NREL/SR-560-32497; (2) Distributed Resources and Electric System Re liability, NREL/SR-560-32498; (3) Distribution System Cost Methodologies for Distributed Generation, NREL/SR-560-32500; (4) Distribution System Cost Methodologies for Distributed Generation Appendices, NREL/SR-560-32501.

  8. Evaluating Behaviorally Oriented Aviation Maintenance Resource Management (MRM) Training and Programs: Methods, Results, and Conclusions

    Science.gov (United States)

    Taylor, James C.; Thomas, Robert L., III

    2003-01-01

    Assessment of the impact of Aviation Resource Management Programs on aviation culture and performance has compelled a considerable body of research (Taylor & Robertson, 1995; Taylor, 1998; Taylor & Patankar, 2001). In recent years new methods have been applied to the problem of maintenance error precipitated by factors such as the need for self-assessment of communication and trust. The present study - 2002 -- is an extension of that past work. This research project was designed as the conclusion of a larger effort to help understand, evaluate and validate the impact of Maintenance Resource Management (MRM) training programs, and other MRM interventions on participant attitudes, opinions, behaviors, and ultimately on enhanced safety performance. It includes research and development of evaluation methodology as well as examination of psychological constructs and correlates of maintainer performance. In particular, during 2002, three issues were addressed. First, the evaluation of two (independent & different) MRM programs for changing behaviors was undertaken. In one case we were able to further apply the approach to measuring written communication developed during 2001 (Taylor, 2002; Taylor & Thomas, 2003). Second, the MRM/TOQ surveys were made available for completion on the internet. The responses from these on-line surveys were automatically linked to a results calculator (like the one developed and described in Taylor, 2002) to aid industry users in analyzing and evaluating their local survey data on the internet. Third, the main trends and themes from our research about MRM programs over the past dozen years were reviewed.

  9. Technical assistance offered to community health programs through a resource model.

    Science.gov (United States)

    Merino, R; Fischer, E; Bosch, S J

    1985-01-01

    A multidisciplinary unit in the Department of Community Medicine, Mount Sinai School of Medicine, consists of a core group of specialists who plan, develop, and evaluate community health care programs. The primary tools used by the staff of the Services Coordination Unit, epidemiology and behavioral and management sciences, result in improved organization and coordination of health services and community resources. The small unit of specialists functions as a resource group, helping community groups address the complex problems of planning, organization, delivery, and financing of health services. By offering technical assistance rather than day-to-day health care services, the unit has established an education and training program in New York's East Harlem, which surrounds the medical school. Over the last 10 years, that approach has enhanced the administrative and financial viability of existing health programs in East Harlem. Since the unit's establishment, it has collaborated with a broad variety of community groups. More than 20 programs have resulted. The income generated by the unit completely covers the expenses and has done so since 1976; "seed money" was used for startup and the first 3 years of operation. The unit is paid for long-term services and for most consultations.

  10. Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway.

    Science.gov (United States)

    Zhang, Zhiguo; Wang, Shudong; Zhou, Shanshan; Yan, Xiaoqing; Wang, Yonggang; Chen, Jing; Mellen, Nicholas; Kong, Maiying; Gu, Junlian; Tan, Yi; Zheng, Yang; Cai, Lu

    2014-12-01

    Type 2 diabetes mellitus (T2DM)-induced cardiomyopathy is associated with cardiac oxidative stress, inflammation, and remodeling. Sulforaphane (SFN), an isothiocyanate naturally presenting in widely consumed vegetables, particularly broccoli, plays an important role in cardiac protection from diabetes. We investigated the effect of SFN on T2DM-induced cardiac lipid accumulation and subsequent cardiomyopathy. Male C57BL/6J mice were fed a high-fat diet for 3months to induce insulin resistance, followed by a treatment with 100mg/kg body-weight streptozotocin to induce hyperglycemia; we referred to it as the T2DM mouse model. Other age-matched mice were fed a normal diet as control. T2DM and control mice were treated with or without 4-month SFN at 0.5mg/kg daily five days a week. At the study's end, cardiac function was assessed. SFN treatment significantly attenuated cardiac remodeling and dysfunction induced by T2DM. SFN treatment also significantly inhibited cardiac lipid accumulation, measured by Oil Red O staining, and improved cardiac inflammation oxidative stress and fibrosis, shown by down-regulating diabetes-induced PAI-1, TNF-α, CTGF, TGF-β, 3-NT, and 4-HNE expression. Elevated 4-HNE resulted in the increase of 4-HNE-LKB1 adducts that should inhibit LKB1 and subsequent AMPK activity. SFN upregulated the expression of Nrf2 and its downstream genes, NQO1 and HO-1, decreased 4-HNE-LKB1 adducts and then reversed diabetes-induced inhibition of LKB1/AMPK and its downstream targets, including sirtuin 1, PGC-1α, phosphorylated acetyl-CoA carboxylase, carnitine palmitoyl transferase-1, ULK1, and light chain-3 II. These results suggest that SFN treatment to T2DM mice may attenuate the cardiac oxidative stress-induced inhibition of LKB1/AMPK signaling pathway, thereby preventing T2DM-induced lipotoxicity and cardiomyopathy. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Dark Skies are a Universal Resource: IYA Programs on Dark Skies Awareness

    Science.gov (United States)

    Walker, Constance E.; Bueter, C.; Pompea, S. M.; Berglund, K.; Mann, T.; Gay, P.; Crelin, B.; Collins, D.; Sparks, R.

    2008-05-01

    The loss of a dark night sky as a natural resource is a growing concern. It impacts not only astronomical research, but also health, ecology, safety, economics and energy conservation. Because of its relevance, "Dark Skies” is a theme of the US Node for the International Year of Astronomy (IYA). Its goal is to raise public awareness of the impact of artificial lighting on local environments by getting people involved in a variety of dark skies-related programs. To reach this goal, the ASP session will immerse participants in hands-on, minds-on activities, events and resources on dark skies awareness. These include a planetarium show on DVD, podcasting, social networking, a digital photography contest, The Great Switch Out, Earth Hour, National Dark Skies Week, a traveling exhibit, a 6-minute video tutorial, Dark Skies Teaching Sites, Astronomy Nights in the (National) Parks, Sidewalk Astronomy Nights, and unaided-eye and digital-meter star counting programs like GLOBE at Night. The ASP "Dark Skies” session is offered to provide IYA dark skies-related programs to a variety of attendees. Participants include professional or amateur astronomers, education and public outreach professionals, science center/museum/planetarium staff and educators who want to lead activities involving dark skies awareness in conjunction with IYA. During the session, each participant will be given a package of educational materials on the various dark skies programs. We will provide the "know-how” and the means for session attendees to become community leaders in promoting these dark skies programs as public events at their home institutions during IYA. Participants will be able to jump-start their education programs through the use of well-developed instructional materials and kits sent later if they commit to leading IYA dark skies activities. For more information about the IYA Dark Skies theme, visit http://astronomy2009.us/darkskies/.

  12. Uranium from Seawater Program Review; Fuel Resources Uranium from Seawater Program DOE Office of Nuclear Energy

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-07-01

    For nuclear energy to remain sustainable in the United States, economically viable sources of uranium beyond terrestrial ores must be developed. The goal of this program is to develop advanced adsorbents that can extract uranium from seawater at twice the capacity of the best adsorbent developed by researchers at the Japan Atomic Energy Agency (JAEA), 1.5 mg U/g adsorbent. A multidisciplinary team from Oak Ridge National Laboratory, Lawrence Berkeley National Laboratory, Pacific Northwest National Laboratory, and the University of Texas at Austin was assembled to address this challenging problem. Polymeric adsorbents, based on the radiation grafting of acrylonitrile and methacrylic acid onto high surface-area polyethylene fibers followed by conversion of the nitriles to amidoximes, have been developed. These poly(acrylamidoxime-co-methacrylic acid) fibers showed uranium adsorption capacities for the extraction of uranium from seawater that exceed 3 mg U/g adsorbent in testing at the Pacific Northwest National Laboratory Marine Sciences Laboratory. The essence of this novel technology lies in the unique high surface-area trunk material that considerably increases the grafting yield of functional groups without compromising its mechanical properties. This technology received an R&D100 Award in 2012. In addition, high surface area nanomaterial adsorbents are under development with the goal of increasing uranium adsorption capacity by taking advantage of the high surface areas and tunable porosity of carbon-based nanomaterials. Simultaneously, de novo structure-based computational design methods are being used to design more selective and stable ligands and the most promising candidates are being synthesized, tested and evaluated for incorporation onto a support matrix. Fundamental thermodynamic and kinetic studies are being carried out to improve the adsorption efficiency, the selectivity of uranium over other metals, and the stability of the adsorbents. Understanding

  13. Geology and mineral resources of the Florence, Beaufort, Rocky Mount, and Norfolk 1/sup 0/ x 2/sup 0/ NTMS quadrangles. National Uranium Resource Evaluation program

    Energy Technology Data Exchange (ETDEWEB)

    Harris, W.B.

    1982-08-01

    This document provides geologic and mineral resources data for previously-issued Savannah River Laboratory hydrogeochemical and stream sediment reports of the Beaufort, Florence, Norfolk, and Rocky Mount 1/sup 0/ x 2/sup 0/ National Topographic Map Series quadrangles in the southeastern United States. This report is issued in draft form, without detailed technical and copy editing. This was done to make the report available to the public before the end of the National Uranium Resource Evaluation program.

  14. Mozambique field epidemiology and laboratory training program: a pathway for strengthening human resources in applied epidemiology.

    Science.gov (United States)

    Baltazar, Cynthia Semá; Taibo, Cátia; Sacarlal, Jahit; Gujral, Lorna; Salomão, Cristolde; Doyle, Timothy

    2017-01-01

    In the last decades, Mozambique has been undergoing demographic, epidemiological, economic and social transitions, which have all had a notable impact on the National Health System. New challenges have emerged, causing a need to expand the preparation and response to emerging disease threats and public health emergencies. We describe the structure and function of the Mozambique Field Epidemiology Training Program (MZ-FELTP) and the main outputs achieved during the first 6 years of program implementation (consisting of 3 cohorts). We also outline the contribution of the program to the National Health System and assess the retention of the graduates. The MZ-FELTP is a post-graduate in-service training program, based on the acquisition of skills, within two tracks: applied epidemiology and laboratory management. The program was established in 2010, with the objective of strengthening capacity in applied epidemiology and laboratory management, so that events of public health importance can be detected and investigated in a timely and effective manner. The program is in its seventh year, having successfully trained 36 health professionals in the advanced course. During the first six years of the program, more than 40 outbreaks were investigated, 37 surveillance system evaluations were conducted and 39 descriptive data analyses were performed. Surveillance activities were implemented for mass events and emergency situations. In addition, more than 100 oral and poster presentations were given by trainees at national and international conferences. The MZ-FELTP has helped provide the Ministry of Health with the human and technical resources and operational capacity, to rapidly and effectively respond to major public health challenges in the country. The continuous involvement of key stakeholders is necessary for the continuation, expansion and ongoing sustainability of the program.

  15. DPS Listing of Planetary Science Graduate Programs: A Resource for Students and Advisors

    Science.gov (United States)

    Klassen, David R.; Jackson, B.; Schneider, N.

    2013-10-01

    Planetary science is a dynamic and diverse discipline that is not a stand alone department at most institutions. Nor is there any one discipline that can said to be the "home" for planetary science. Typically, research scientists earn a PhD in a field such as geology, chemistry, astronomy, physics, etc. while focusing their research in that area to planetary or solar system oriented topics. While this inherent diversity in our field is one of its greatest strengths, it can be a source of great confusion to undergraduates considering our field for advanced study. Because of this, we have attempted to compile a list of the graduate programs which can lead to a PhD with a planetary science focus. The list is meant to be a first-stop shop for undergraduate students and undergraduate advisors where they can find programs, compare them across some very basic informational categories, and follow links to the programs' web sites for further information. While the list is extensive, it is most likely not comprehensive and we will continue to add programs as we find out about them. In addition, we will continue reaching out to programs and admissions chairs to help complete the current entries and keep them up-to-date. We preset here the background work that went into compiling and sorting the list of programs, the data fields recorded for each program, and some notes on future directions. Additionally, we call upon those mentoring and advising undergraduate to use this resource and program admission chairs to review their entry and provide us with the most up-to-date information.

  16. Hydrologic Resources Management Program and Underground Test Area Project FY2005 Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Eaton, G F; Genetti, V; Hu, Q; Hudson, G B; Kersting, A B; Lindvall, R E; Moran, J E; Nimz, G J; Ramon, E C; Rose, T P; Shuller, L; Williams, R W; Zavarin, M; Zhao, P

    2007-03-23

    This report describes FY 2005 technical studies conducted by the Chemical Biology and Nuclear Science Division (CBND) at Lawrence Livermore National Laboratory (LLNL) in support of the Hydrologic Resources Management Program (HRMP) and the Underground Test Area Project (UGTA). These programs are administered by the U.S. Department of Energy, National Nuclear Security Administration, Nevada Site Office (NNSA/NSO) through the Defense Programs and Environmental Restoration Divisions, respectively. HRMP-sponsored work is directed toward the responsible management of the natural resources at the Nevada Test Site (NTS), enabling its continued use as a staging area for strategic operations in support of national security. UGTA-funded work emphasizes the development of an integrated set of groundwater flow and contaminant transport models to predict the extent of radionuclide migration from underground nuclear testing areas at the NTS. The report is organized on a topical basis and contains five chapters that highlight technical work products produced by CBND. However, it is important to recognize that most of this work involves collaborative partnerships with the other HRMP and UGTA contract organizations. These groups include the Energy and Environment Directorate at LLNL (LLNL-E&E), Los Alamos National Laboratory (LANL), the Desert Research Institute (DRI), the U.S. Geological Survey (USGS), Stoller-Navarro Joint Venture (SNJV), and Bechtel Nevada (BN).

  17. 1995 Annual wildlife survey report. Natural Resource Protection and Compliance Program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-25

    This report summarizes the results of wildlife surveys performed at Rocky Flats Environmental Technology Site (RFETS) from January through December of 1995 as compared with results from previous years. These surveys were performed as part of a long-term ecological monitoring program conducted under the Natural Resource Protection and Compliance Program (NRPCP). This program is essential in identifying and describing fluctuations of wildlife populations, wildlife habitat use, and changes in species using RFETS. The NRPCP provides support to the Department of Energy (DOE) in its role as Natural Resource Trustee, and provides data essential to accomplishing the goal of preserving the unique ecological values of RFETS in keeping with the Rocky Flats Vision presented in the Rocky Flats Cleanup Agreement Public Comment Draft. Wildlife population densities vary due to natural pressures and human influences, and only long-term monitoring can verify which factors influencing wildlife populations are the consequence of natural fluctuations, and which are due to human influences. The wildlife monitoring described in this report provides qualitative data that give an indication of the ecological health of RFETS. Monitoring numbers, habitat affinities, and apparent health of the wildlife populations makes it possible to evaluate the overall ecological health of the site. Monitoring and surveys such as those carried out by the NRPCP can indicate trends of this sort, and act as an {open_quotes}early warning system{close_quotes} for impending ecological problems.

  18. Optimizing conjunctive use of surface water and groundwater resources with stochastic dynamic programming

    DEFF Research Database (Denmark)

    Davidsen, Claus; Liu, Suxia; Mo, Xinguo

    2014-01-01

    to head-dependent pumping costs. These dynamic pumping costs strongly affect the total costs and can lead to non-convexity of the future cost function. The water user groups (agriculture, industry, domestic) are characterized by inelastic demands and fixed water allocation and water supply curtailment......Optimal management of conjunctive use of surface water and groundwater has been attempted with different algorithms in the literature. In this study, a hydro-economic modelling approach to optimize conjunctive use of scarce surface water and groundwater resources under uncertainty is presented....... A stochastic dynamic programming (SDP) approach is used to minimize the basin-wide total costs arising from water allocations and water curtailments. Dynamic allocation problems with inclusion of groundwater resources proved to be more complex to solve with SDP than pure surface water allocation problems due...

  19. Building sustainable organizational capacity to deliver HIV programs in resource-constrained settings: stakeholder perspectives.

    Science.gov (United States)

    Sharma, Anjali; Chiliade, Philippe; Michael Reyes, E; Thomas, Kate K; Collens, Stephen R; Rafael Morales, José

    2013-12-13

    In 2008, the US government mandated that HIV/AIDS care and treatment programs funded by the US President's Emergency Plan for AIDS Relief (PEPFAR) should shift from US-based international partners (IPs) to registered locally owned organizations (local partners, or LPs). The US Health Resources and Services Administration (HRSA) developed the Clinical Assessment for Systems Strengthening (ClASS) framework for technical assistance in resource-constrained settings. The ClASS framework involves all stakeholders in the identification of LPs' strengths and needs for technical assistance. This article examines the role of ClASS in building capacity of LPs that can endure and adapt to changing financial and policy environments. All stakeholders (n=68) in Kenya, Zambia, and Nigeria who had participated in the ClASS from LPs and IPs, the US Centers for Disease Control and Prevention (CDC), and, in Nigeria, HIV/AIDS treatment facilities (TFs) were interviewed individually or in groups (n=42) using an open-ended interview guide. Thematic analysis revealed stakeholder perspectives on ClASS-initiated changes and their sustainability. Local organizations were motivated to make changes in internal operations with the ClASS approach, PEPFAR's competitive funding climate, organizational goals, and desired patient health outcomes. Local organizations drew on internal resources and, if needed, technical assistance from IPs. Reportedly, ClASS-initiated changes and remedial action plans made LPs more competitive for PEPFAR funding. LPs also attributed their successful funding applications to their preexisting systems and reputation. Bureaucracy, complex and competing tasks, and staff attrition impeded progress toward the desired changes. Although CDC continues to provide technical assistance through IPs, declining PEPFAR funds threaten the consolidation of gains, smooth program transition, and continuity of treatment services. The well-timed adaptation and implementation of Cl

  20. Learning to Thrive: Building Diverse Scientists’ Access to Community and Resources through the BRAINS Program

    Science.gov (United States)

    Margherio, Cara; Horner-Devine, M. Claire; Mizumori, Sheri J. Y.; Yen, Joyce W.

    2016-01-01

    BRAINS: Broadening the Representation of Academic Investigators in NeuroScience is a National Institutes of Health–funded, national program that addresses challenges to the persistence of diverse early-career neuroscientists. In doing so, BRAINS aims to advance diversity in neuroscience by increasing career advancement and retention of post-PhD, early-career neuroscientists from underrepresented groups (URGs). The comprehensive professional development program is structured to catalyze conversations specific to URGs in neuroscience and explicitly addresses factors known to impact persistence such as a weak sense of belonging to the scientific community, isolation and solo status, inequitable access to resources that impact career success, and marginalization from informal networks and mentoring relationships. While we do not yet have data on the long-term impact of the BRAINS program on participants’ career trajectory and persistence, we introduce the BRAINS program theory and report early quantitative and qualitative data on shorter-term individual impacts within the realms of career-advancing behaviors and career experiences. These early results suggest promising, positive career productivity, increased self-efficacy, stronger sense of belonging, and new perspectives on navigating careers for BRAINS participants. We finish by discussing recommendations for future professional development programs and research designed to broaden participation in the biomedical and life sciences. PMID:27587858

  1. Medical education resources initiative for teens program in baltimore: A model pipeline program built on four pillars.

    Science.gov (United States)

    Mains, Tyler E; Wilcox, Mark V; Wright, Scott M

    2016-01-01

    Less than 6% of U.S. medical school applicants are African-American. The lack of diversity among physicians, by race as well as other measures, confers a negative impact on the American healthcare system because underrepresented minority (URM) physicians are more likely to practice in underserved communities and deliver more equitable, culturally competent care. MERIT (Medical Education Resources Initiative for Teens) is a nonprofit organization based in Baltimore, Maryland, USA. MERIT prepares URM high school students for health careers by providing a holistic support system for seven consecutive years. The program model, which utilizes weekly Saturday sessions, summer internships, and longitudinal mentoring, is built on four foundational pillars: (1) Ignite the Fire, (2) Illuminate the Path, (3) Create the Toolkit, and (4) Sustain the Desire. Since 2011, MERIT has supported 51 students in the Baltimore City Public School System. For the past two years, 100% (n = 14) of MERIT seniors enrolled in universities, compared to only 20.2% of Baltimore City students overall. While it is too early to know whether MERIT alumni will realize their goals of becoming healthcare professionals, they are currently excelling in universities and over 75% (n = 17) are still planning to pursue graduate degrees in health-related fields. After piloting an effective program model, MERIT now has three key priorities moving forward: (1) Creating a sustainable and thriving organization, (2) increasing the number of scholars the program supports in Baltimore, and (3) expanding MERIT to other cities.

  2. Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activatio.

    Science.gov (United States)

    Wang, Yurong; Wang, Bin; Guerram, Mounia; Sun, Li; Shi, Wei; Tian, Chongchong; Zhu, Xiong; Jiang, Zhenzhou; Zhang, Luyong

    2015-10-06

    Angiogenesis plays a critical role in the growth and metastasis of tumors, which makes it an attractive target for anti-tumor drug development. Deoxypodophyllotoxin (DPT), a natural product isolated from Anthriscus sylvestris, inhibits cell proliferation and migration in various cancer cell types. Our previous studies indicate that DPT possesses both anti-angiogenic and vascular-disrupting activities. Although the RhoA/ RhoA kinase (ROCK) signaling pathway is implicated in DPT-stimulated cytoskeleton remodeling and tumor vasculature suppressing, the detailed mechanisms by which DPT mediates these effects are poorly understood. In the current study, we found that DPT promotes cytoskeleton remodeling in human umbilical vein endothelial cells (HUVECs) via stimulation of AMP-activated protein kinase (AMPK) and that this effect is abolished by either treatment with a selective AMPK inhibitor or knockdown. Moreover, the cellular levels of LKB1, a kinase upstream of AMPK, were enhanced following DPT exposure. DPT-induced activation of AMPK in tumor vasculature effect was also verified by transgenic zebrafish (VEGFR2:GFP), Matrigel plug assay, and xenograft model in nude mice. The present findings may lay the groundwork for a novel therapeutic approach in treating cancer.

  3. Final Scientific / Technical Report, Geothermal Resource Exploration Program, Truckhaven Area, Imperial County, California

    Energy Technology Data Exchange (ETDEWEB)

    Layman Energy Associates, Inc.

    2006-08-15

    With financial support from the U.S. Department of Energy (DOE), Layman Energy Associates, Inc. (LEA) has completed a program of geothermal exploration at the Truckhaven area in Imperial County, California. The exploratory work conducted by LEA included the following activities: compilation of public domain resource data (wells, seismic data, geologic maps); detailed field geologic mapping at the project site; acquisition and interpretation of remote sensing imagery such as aerial and satellite photographs; acquisition, quality control and interpretation of gravity data; and acquisition, quality control and interpretation of resistivity data using state of the art magnetotelluric (MT) methods. The results of this exploratory program have allowed LEA to develop a structural and hydrologic interpretation of the Truckhaven geothermal resource which can be used to guide subsequent exploratory drilling and resource development. Of primary significance, is the identification of an 8 kilometer-long, WNW-trending zone of low resistivity associated with geothermal activity in nearby wells. The long axis of this low resistivity zone is inferred to mark a zone of faulting which likely provides the primary control on the distribution of geothermal resources in the Truckhaven area. Abundant cross-faults cutting the main WNW-trending zone in its western half may indicate elevated fracture permeability in this region, possibly associated with thermal upwelling and higher resource temperatures. Regional groundwater flow is inferred to push thermal fluids from west to east along the trend of the main low resistivity zone, with resource temperatures likely declining from west to east away from the inferred upwelling zone. Resistivity mapping and well data have also shown that within the WNW-trending low resistivity zone, the thickness of the Plio-Pleistocene sedimentary section above granite basement ranges from 1,900–2,600 meters. Well data indicates the lower part of this

  4. Evaluation of the Waste Tire Resources Recovery Program and Environmental Health Policy in Taiwan

    Directory of Open Access Journals (Sweden)

    Chia-Ching Chen

    2009-03-01

    Full Text Available This paper examines the effectiveness of Taiwanese environmental health policies, whose aim is to improve environmental quality by reducing tire waste via the Tire Resource Recovery Program. The results confirm that implemented environmental health policies improve the overall health of the population (i.e. a decrease in death caused by bronchitis and other respiratory diseases. Current policy expenditures are far below the optimal level, as it is estimated that a ten percent increase in the subsidy would decrease the number of deaths caused by bronchitis and other respiratory diseases by 0.58% per county/city per year on average.

  5. Community resources and technologies developed through the NIH Roadmap Epigenomics Program.

    Science.gov (United States)

    Satterlee, John S; Beckel-Mitchener, Andrea; McAllister, Kim; Procaccini, Dena C; Rutter, Joni L; Tyson, Frederick L; Chadwick, Lisa Helbling

    2015-01-01

    This chapter describes resources and technologies generated by the NIH Roadmap Epigenomics Program that may be useful to epigenomics researchers investigating a variety of diseases including cancer. Highlights include reference epigenome maps for a wide variety of human cells and tissues, the development of new technologies for epigenetic assays and imaging, the identification of novel epigenetic modifications, and an improved understanding of the role of epigenetic processes in a diversity of human diseases. We also discuss future needs in this area including exploration of epigenomic variation between individuals, single-cell epigenomics, environmental epigenomics, exploration of the use of surrogate tissues, and improved technologies for epigenome manipulation.

  6. Human resource management in the Georgian National Immunization Program: a baseline assessment

    Directory of Open Access Journals (Sweden)

    Cohen-Kohler Jillian

    2007-07-01

    Full Text Available Abstract Background Georgia's health care system underwent dramatic reform after gaining independence in 1991. The decentralization of the health care system was one of the core elements of health care reform but reports suggest that human resource management issues were overlooked. The Georgian national immunization program was affected by these reforms and is not functioning at optimum levels. This paper describes the state of human resource management practices within the Georgian national immunization program in late 2004. Methods Thirty districts were selected for the study. Within these districts, 392 providers and thirty immunization managers participated in the study. Survey questionnaires were administered through face-to-face interviews to immunization managers and a mail survey was administered to immunization providers. Qualitative data collection involved four focus groups. Analysis of variance (ANOVA and Chi-square tests were used to test for differences between groups for continuous and categorical variables. Content analysis identified main themes within the focus groups. Results Weak administrative links exist between the Centres of Public Health (CPH and Primary Health Care (PHC health facilities. There is a lack of clear management guidelines and only 49.6% of all health providers had written job descriptions. A common concern among all respondents was the extremely inadequate salary. Managers cited lack of authority and poor knowledge and skills in human resource management. Lack of resources and infrastructure were identified as major barriers to improving immunization. Conclusion Our study found that the National Immunization Program in Georgia was characterized by weak organizational structure and processes and a lack of knowledge and skills in management and supervision, especially at peripheral levels. The development of the skills and processes of a well-managed workforce may help improve immunization rates, facilitate

  7. Supplement to the bridge resource program : state-of-the-art practices of mass concrete - a literature review.

    Science.gov (United States)

    2013-09-01

    The mission of Rutgers Universitys Center for Advanced Infrastructure and Transportation (CAIT) Bridge Resource Program : (BRP) is to provide bridge engineering support to the New Jersey Department of Transportation (NJDOT)s Bridge : Engineerin...

  8. Gulf Coast geopressured-geothermal program summary report compilation. Volume 2-A: Resource description, program history, wells tested, university and company based research, site restoration

    Energy Technology Data Exchange (ETDEWEB)

    John, C.J.; Maciasz, G.; Harder, B.J.

    1998-06-01

    The US Department of Energy established a geopressured-geothermal energy program in the mid 1970`s as one response to America`s need to develop alternate energy resources in view of the increasing dependence on imported fossil fuel energy. This program continued for 17 years and approximately two hundred million dollars were expended for various types of research and well testing to thoroughly investigate this alternative energy source. This volume describes the following studies: Geopressured-geothermal resource description; Resource origin and sediment type; Gulf Coast resource extent; Resource estimates; Project history; Authorizing legislation; Program objectives; Perceived constraints; Program activities and structure; Well testing; Program management; Program cost summary; Funding history; Resource characterization; Wells of opportunity; Edna Delcambre No. 1 well; Edna Delcambre well recompletion; Fairfax Foster Sutter No. 2 well; Beulah Simon No. 2 well; P.E. Girouard No. 1 well; Prairie Canal No. 1 well; Crown Zellerbach No. 2 well; Alice C. Plantation No. 2 well; Tenneco Fee N No. 1 well; Pauline Kraft No. 1 well; Saldana well No. 2; G.M. Koelemay well No. 1; Willis Hulin No. 1 well; Investigations of other wells of opportunity; Clovis A. Kennedy No. 1 well; Watkins-Miller No. 1 well; Lucien J. Richard et al No. 1 well; and the C and K-Frank A. Godchaux, III, well No. 1.

  9. Identifying State Resources and Support Programs on E-Government Websites for Persons with Intellectual and Developmental Disabilities

    OpenAIRE

    Fisher, Kathleen M.; Peterson, Justin D.; Albert, Jon D.

    2015-01-01

    This descriptive cross-sectional study identified resources and programs that are available nationwide on the Internet to support individuals and families with intellectual and developmental disabilities (I/DD), with a focus on intellectual disability. This evaluation included easily identifiable information on specific resources and highlighted unique programs found in individual states that were linked from e-government websites. Researchers documented the ease of access and available infor...

  10. DPS Planetary Science Graduate Programs Listing: A Resource for Students and Advisors

    Science.gov (United States)

    Klassen, David R.; Roman, Anthony; Meinke, Bonnie

    2015-11-01

    We began a web page on the DPS Education site in 2013 listing all the graduate programs we could find that can lead to a PhD with a planetary science focus. Since then the static page has evolved into a database-driven, filtered-search site. It is intended to be a useful resource for both undergraduate students and undergraduate advisers, allowing them to find and compare programs across a basic set of search criteria. From the filtered list users can click on links to get a "quick look" at the database information and follow links to the program main site.The reason for such a list is because planetary science is a heading that covers an extremely diverse set of disciplines. The usual case is that planetary scientists are housed in a discipline-placed department so that finding them is typically not easy—undergraduates cannot look for a Planetary Science department, but must (somehow) know to search for them in all their possible places. This can overwhelm even determined undergraduate student, and even many advisers!We present here the updated site and a walk-through of the basic features. In addition we ask for community feedback on additional features to make the system more usable for them. Finally, we call upon those mentoring and advising undergraduates to use this resource, and program admission chairs to continue to review their entry and provide us with the most up-to-date information.The URL for our site is http://dps.aas.org/education/graduate-schools.

  11. 1994 Annual wildlife survey report. Natural Resource Protection and Compliance Program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-24

    This report summarizes the results of wildlife surveys and other wildlife monitoring performed from January through December 1994. These surveys are part of a long-term ecological monitoring program conducted under the Natural Resource Protection and Compliance Program (NRPCP). This program is essential in identifying and quantifying fluctuations of wildlife populations, wildlife habitat use, and changes in the species using the Rocky Flats Environmental Technology Site (Site) as year-round or seasonal habitat. Wildlife population densities vary constantly due to natural pressures, and only well-integrated, long-term monitoring can identify which factors influencing wildlife populations are a consequence of natural causes, and which are due to human activities. An integrated monitoring program that gathers data on ecologically interactive species is essential in evaluating population fluctuations. Such data can be an invaluable tool in predicting and avoiding impacts on the ecology of an area due to projected human activities. With 167 species of birds, three big game species, nine species of carnivores, nine species of mid-sized mammals, and 15 small mammal species, the Site provides habitat to a surprising variety of wildlife. Many of these species are sensitive species or indicator organisms that by their presence or, more significantly, by their absence can indicate the ecological health of an area. Their presence at the Site indicates a very healthy ecosystem.

  12. Annual review of cultural resource investigations by the Savannah River Archaeological Research Program. Fiscal year 1995

    Energy Technology Data Exchange (ETDEWEB)

    Brooks, M.J.; Brooks, R.D.; Sassaman, K.E.; Crass, D.C. [and others

    1995-10-01

    The Savannah River Archaeological Research Program (SRARP) continued through FY95 with the United States Department of Energy to fulfill a threefold mission of cultural resource management, research, and public education at the Savannah River Site. Over 2,300 acres of land on the SRS came under cultural resources review in FY95. This activity entailed 30 field surveys, resulting in the recording of 86 new sites. Twenty-two existing sites within survey tract boundaries were revisited to update site file records. Research conducted by SRARP was reported in 11 papers and monographs published during FY95. SRARP staff also presented research results in 18 papers at professional meetings. Field research included several testing programs, excavations, and remote sensing at area sites, as well as data collection abroad. Seven grants were acquired by SRARP staff to support off-site research. In the area of heritage education, the SRARP expanded its activities in FY95 with a full schedule of classroom education, public outreach, and on-site tours. Volunteer excavations at the Tinker Creek site were continued with the Augusta Archaeological Society and other avocational groups, and other off-site excavations provided a variety of opportunities for field experience. Some 80 presentations, displays and tours were provided for schools, historical societies, civic groups, and environmental and historical awareness day celebrations. Additionally, SRARP staff taught four anthropology courses at area colleges.

  13. Human resource development for a community-based health extension program: a case study from Ethiopia.

    Science.gov (United States)

    Teklehaimanot, Hailay D; Teklehaimanot, Awash

    2013-08-20

    Ethiopia is one of the sub-Saharan countries most affected by high disease burden, aggravated by a shortage and imbalance of human resources, geographical distance, and socioeconomic factors. In 2004, the government introduced the Health Extension Program (HEP), a primary care delivery strategy, to address the challenges and achieve the World Health Organization Millennium Development Goals (MDGs) within a context of limited resources. The health system was reformed to create a platform for integration and institutionalization of the HEP with appropriate human capacity, infrastructure, and management structures. Human resources were developed through training of female health workers recruited from their prospective villages, designed to limit the high staff turnover and address gender, social and cultural factors in order to provide services acceptable to each community. The service delivery modalities include household, community and health facility care. Thus, the most basic health post infrastructure, designed to rapidly and cost-effectively scale up HEP, was built in each village. In line with the country's decentralized management system, the HEP service delivery is under the jurisdiction of the district authorities. The nationwide implementation of HEP progressed in line with its target goals. In all, 40 training institutions were established, and over 30,000 Health Extension Workers have been trained and deployed to approximately 15,000 villages. The potential health service coverage reached 92.1% in 2011, up from 64% in 2004. While most health indicators have improved, performance in skilled delivery and postnatal care has not been satisfactory. While HEP is considered the most important institutional framework for achieving the health MDGs in Ethiopia, quality of service, utilization rate, access and referral linkage to emergency obstetric care, management, and evaluation of the program are the key challenges that need immediate attention. This article

  14. Dark Skies are a Universal Resource: Programs Planned for the International Year of Astronomy

    Science.gov (United States)

    Walker, Constance E.; US IYA Dark Skies Working Group

    2008-05-01

    The dark night sky is a natural resource that is being lost by much of the world's population. This loss is a growing, serious issue that impacts not only astronomical research, but also human health, ecology, safety, economics and energy conservation. One of the themes of the US Node targeted for the International Year of Astronomy (IYA) is "Dark Skies are a Universal Resource". The goal is to raise public awareness of the impact of artificial lighting on local environments by getting people involved locally in a variety of dark skies-related events. To reach this goal, activities are being developed that: 1) Teach about dark skies using new technology (e.g., an activity-based planetarium show on DVD, podcasting, social networking) 2) Provide thematic events on light pollution at star parties and observatory open houses (Dark Skies Teaching Sites, Astronomy Nights in the (National) Parks, Sidewalk Astronomy Nights) 3) Organize events in the arts (e.g., a photography contest) 4) Involve citizen-scientists in unaided-eye and digital-meter star counting programs (e.g., GLOBE at Night, "How Many Stars?” and the Great World Wide Star Count) and 5) Raise awareness about the link between light pollution and public health, economic issues, ecological consequences, energy conservation, safety and security (e.g., The Great Switch Out, Earth Hour, National Dark Skies Week, traveling exhibits and a 6-minute video tutorial on lighting issues). To deliver these programs, strategic networks have been established with the ASP's Night Sky Network's astronomy clubs, Astronomy from the Ground Up's science and nature centers and the Project and Family ASTRO programs, as well as the International Dark-Sky Association, GLOBE and the Astronomical League, among others. The poster presentation will outline the activities being developed, the plans for funding, implementation, marketing and the connections to the global cornerstone IYA project, "Dark Skies Awareness".

  15. A crew resource management program tailored to trauma resuscitation improves team behavior and communication.

    Science.gov (United States)

    Hughes, K Michael; Benenson, Ronald S; Krichten, Amy E; Clancy, Keith D; Ryan, James Patrick; Hammond, Christopher

    2014-09-01

    Crew Resource Management (CRM) is a team-building communication process first implemented in the aviation industry to improve safety. It has been used in health care, particularly in surgical and intensive care settings, to improve team dynamics and reduce errors. We adapted a CRM process for implementation in the trauma resuscitation area. An interdisciplinary steering committee developed our CRM process to include a didactic classroom program based on a preimplementation survey of our trauma team members. Implementation with new cultural and process expectations followed. The Human Factors Attitude Survey and Communication and Teamwork Skills assessment tool were used to design, evaluate, and validate our CRM program. The initial trauma communication survey was completed by 160 team members (49% response). Twenty-five trauma resuscitations were observed and scored using Communication and Teamwork Skills. Areas of concern were identified and 324 staff completed our 3-hour CRM course during a 3-month period. After CRM training, 132 communication surveys and 38 Communication and Teamwork Skills observations were completed. In the post-CRM survey, respondents indicated improvement in accuracy of field to medical command information (p = 0.029); accuracy of emergency department medical command information to the resuscitation area (p = 0.002); and team leader identity, communication of plan, and role assignment (p = 0.001). After CRM training, staff were more likely to speak up when patient safety was a concern (p = 0.002). Crew Resource Management in the trauma resuscitation area enhances team dynamics, communication, and, ostensibly, patient safety. Philosophy and culture of CRM should be compulsory components of trauma programs and in resuscitation of injured patients. Copyright © 2014 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

  16. Using analytical tools for decision-making and program planning in natural resources: breaking the fear barrier

    Science.gov (United States)

    David L. Peterson; Daniel L. Schmoldt

    1999-01-01

    The National Park Service and other public agencies are increasing their emphasis on inventory and monitoring (I&M) programs to obtain the information needed to infer changes in resource conditions and trigger management responses.A few individuals on a planning team can develop I&M programs, although a focused workshop is more effective.Workshops are...

  17. Resource and cost adjustment in the design of allocation funding formulas in public health programs.

    Science.gov (United States)

    Buehler, James W; Bernet, Patrick M; Ogden, Lydia L

    2012-01-01

    Multiple federal public health programs use funding formulas to allocate funds to states. To characterize the effects of adjusting formula-based allocations for differences among states in the cost of implementing programs, the potential for generating in-state resources, and income disparities, which might be associated with disease risk. Fifty US states and the District of Columbia. Formula-based funding allocations to states for 4 representative federal public health programs were adjusted using indicators of cost (average salaries), potential within-state revenues (per-capita income, the Federal Medical Assistance Percentage, per-capita aggregate home values), and income disparities (Theil index). Percentage of allocation shifted by adjustment, the number of states and the percentage of US population living in states with a more than 20% increase or decrease in funding, maximum percentage increase or decrease in funding. Each adjustor had a comparable impact on allocations across the 4 program allocations examined. Approximately 2% to 8% of total allocations were shifted, with adjustments for variations in income disparity and housing values having the least and greatest effects, respectively. The salary cost and per-capita income adjustors were inversely correlated and had offsetting effects on allocations. With the exception of the housing values adjustment, fewer than 10 states had more than 20% increases or decreases in allocations, and less than 10% of the US population lived in such states. Selection of adjustors for formula-based funding allocations should consider the impacts of different adjustments, correlations between adjustors and other data elements in funding formulas, and the relationship of formula inputs to program objectives.

  18. Learning to Thrive: Building Diverse Scientists' Access to Community and Resources through the BRAINS Program.

    Science.gov (United States)

    Margherio, Cara; Horner-Devine, M Claire; Mizumori, Sheri J Y; Yen, Joyce W

    2016-01-01

    Broadening the Representation of Academic Investigators in NeuroScience is a National Institutes of Health-funded, national program that addresses challenges to the persistence of diverse early-career neuroscientists. In doing so, BRAINS aims to advance diversity in neuroscience by increasing career advancement and retention of post-PhD, early-career neuroscientists from underrepresented groups (URGs). The comprehensive professional development program is structured to catalyze conversations specific to URGs in neuroscience and explicitly addresses factors known to impact persistence such as a weak sense of belonging to the scientific community, isolation and solo status, inequitable access to resources that impact career success, and marginalization from informal networks and mentoring relationships. While we do not yet have data on the long-term impact of the BRAINS program on participants' career trajectory and persistence, we introduce the BRAINS program theory and report early quantitative and qualitative data on shorter-term individual impacts within the realms of career-advancing behaviors and career experiences. These early results suggest promising, positive career productivity, increased self-efficacy, stronger sense of belonging, and new perspectives on navigating careers for BRAINS participants. We finish by discussing recommendations for future professional development programs and research designed to broaden participation in the biomedical and life sciences. © 2016 C. Margherio et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  19. Building sustainable organizational capacity to deliver HIV programs in resource-constrained settings: stakeholder perspectives

    Directory of Open Access Journals (Sweden)

    Anjali Sharma

    2013-12-01

    Full Text Available Background: In 2008, the US government mandated that HIV/AIDS care and treatment programs funded by the US President's Emergency Plan for AIDS Relief (PEPFAR should shift from US-based international partners (IPs to registered locally owned organizations (local partners, or LPs. The US Health Resources and Services Administration (HRSA developed the Clinical Assessment for Systems Strengthening (ClASS framework for technical assistance in resource-constrained settings. The ClASS framework involves all stakeholders in the identification of LPs’ strengths and needs for technical assistance. Objective: This article examines the role of ClASS in building capacity of LPs that can endure and adapt to changing financial and policy environments. Design: All stakeholders (n=68 in Kenya, Zambia, and Nigeria who had participated in the ClASS from LPs and IPs, the US Centers for Disease Control and Prevention (CDC, and, in Nigeria, HIV/AIDS treatment facilities (TFs were interviewed individually or in groups (n=42 using an open-ended interview guide. Thematic analysis revealed stakeholder perspectives on ClASS-initiated changes and their sustainability. Results: Local organizations were motivated to make changes in internal operations with the ClASS approach, PEPFAR's competitive funding climate, organizational goals, and desired patient health outcomes. Local organizations drew on internal resources and, if needed, technical assistance from IPs. Reportedly, ClASS-initiated changes and remedial action plans made LPs more competitive for PEPFAR funding. LPs also attributed their successful funding applications to their preexisting systems and reputation. Bureaucracy, complex and competing tasks, and staff attrition impeded progress toward the desired changes. Although CDC continues to provide technical assistance through IPs, declining PEPFAR funds threaten the consolidation of gains, smooth program transition, and continuity of treatment services

  20. Results from utility wind resource assessment programs in Nebraska, Colorado, and Arizona

    Energy Technology Data Exchange (ETDEWEB)

    Drapeau, C.L. [Global Energy Concepts, Inc., Bothell, WA (United States)

    1997-12-31

    Global Energy Concepts (GEC) has been retained by utilities in Colorado, Nebraska, and Arizona to site, install, and operate 21 wind monitoring stations as part of the Utility Wind Resource Assessment Program (U*WRAP). Preliminary results indicate wind speed averages at 40 meters (132 ft) of 6.5 - 7.4 m/s (14.5-16.5 mph) in Nebraska and 7.6 - 8.9 m/s (17.0-19.9 mph) in Colorado. The Arizona stations are not yet operational. This paper presents the history and current status of the 21 monitoring stations as well as preliminary data results. Information on wind speeds, wind direction, turbulence intensity, wind shear, frequency distribution, and data recovery rates are provided.

  1. An object-oriented programming system for the integration of internet-based bioinformatics resources.

    Science.gov (United States)

    Beveridge, Allan

    2006-01-01

    The Internet consists of a vast inhomogeneous reservoir of data. Developing software that can integrate a wide variety of different data sources is a major challenge that must be addressed for the realisation of the full potential of the Internet as a scientific research tool. This article presents a semi-automated object-oriented programming system for integrating web-based resources. We demonstrate that the current Internet standards (HTML, CGI [common gateway interface], Java, etc.) can be exploited to develop a data retrieval system that scans existing web interfaces and then uses a set of rules to generate new Java code that can automatically retrieve data from the Web. The validity of the software has been demonstrated by testing it on several biological databases. We also examine the current limitations of the Internet and discuss the need for the development of universal standards for web-based data.

  2. The SCEC/UseIT Intern Program: Creating Open-Source Visualization Software Using Diverse Resources

    Science.gov (United States)

    Francoeur, H.; Callaghan, S.; Perry, S.; Jordan, T.

    2004-12-01

    The Southern California Earthquake Center undergraduate IT intern program (SCEC UseIT) conducts IT research to benefit collaborative earth science research. Through this program, interns have developed real-time, interactive, 3D visualization software using open-source tools. Dubbed LA3D, a distribution of this software is now in use by the seismic community. LA3D enables the user to interactively view Southern California datasets and models of importance to earthquake scientists, such as faults, earthquakes, fault blocks, digital elevation models, and seismic hazard maps. LA3D is now being extended to support visualizations anywhere on the planet. The new software, called SCEC-VIDEO (Virtual Interactive Display of Earth Objects), makes use of a modular, plugin-based software architecture which supports easy development and integration of new data sets. Currently SCEC-VIDEO is in beta testing, with a full open-source release slated for the future. Both LA3D and SCEC-VIDEO were developed using a wide variety of software technologies. These, which included relational databases, web services, software management technologies, and 3-D graphics in Java, were necessary to integrate the heterogeneous array of data sources which comprise our software. Currently the interns are working to integrate new technologies and larger data sets to increase software functionality and value. In addition, both LA3D and SCEC-VIDEO allow the user to script and create movies. Thus program interns with computer science backgrounds have been writing software while interns with other interests, such as cinema, geology, and education, have been making movies that have proved of great use in scientific talks, media interviews, and education. Thus, SCEC UseIT incorporates a wide variety of scientific and human resources to create products of value to the scientific and outreach communities. The program plans to continue with its interdisciplinary approach, increasing the relevance of the

  3. Experience of health-system pharmacy administration residents in a longitudinal human resource management program.

    Science.gov (United States)

    Amerine, Lindsey B Poppe; Granko, Robert P; Savage, Scott W; Daniels, Rowell; Eckel, Stephen F

    2014-12-15

    The experience of health-system pharmacy administration (HSPA) residents in a longitudinal human resource (HR) management program is described. The subsequent benefits to the residents, department, and profession are also discussed. Postgraduate year 2 HSPA residents at an academic medical center desired more responsibility for managing an operational area. To this end, a program was created in which these residents directly manage a small group of pharmacy technicians and report to a clinical manager or assistant director with oversight responsibility. These "resident managers" are responsible, under the direction of the area's clinical manager, for the personnel, schedule, time and attendance, and HR activities of the area. Resident managers have led and sustained operational improvement projects in their areas. In addition to providing learning experiences to residents, the HSPA residency program has also improved the operations of the areas in which these residents work. Benefits to the residents include conducting annual performance evaluations for employees with whom they have a relationship as it is a task every administrator completes. Resident managers at UNC have consistently stated that this longitudinal HR experience is one of the most rewarding and most challenging experiences offered in the two-year HSPA residency. The involvement of HSPA residents in longitudinal management responsibilities furthers residents' leadership success by providing trained managers who are ready to immerse themselves into practice postresidency, having employee engagement and HR skills as well as experiences with leading operational improvements. A longitudinal HR management experience was successfully incorporated into an HSPA residency combined Master of Science degree program. Copyright © 2014 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

  4. Starting and resourcing family and internal medicine residency programs as integral mission

    Directory of Open Access Journals (Sweden)

    Stephen P Merry

    2016-01-01

    Full Text Available Graduate medical education is an excellent means of building the capacity of health care systems in low and middle Income Countries (LMIC and a growing way for physicians in the U.S to get involved in integral mission – the proclamation and demonstration of the Gospel. This white paper purposes to provide a “best practices” recommendations on family and internal medicine (“medical” residency program development in majority world settings. An expert panel of residency educators convened in November 2015 at the Global Missions Health Conference (GMHC in Louisville, Kentucky and through an iterative process identified themes that were then further defined and clarified by medical residency faculty unable to be present. Participants largely agreed that integration and cooperation with the country’s Ministry of Health (MOH is essential for sustainable residency development. Recognition of family medicine as a specialty will enable graduates to succeed in the country’s physician job market and health systems leadership. Recognition by the national church of the unique needs of their mission hospitals’ educational programs to control their revenue in order to fund their programs’ growth and development exemplifies the common wisdom to provide authority and resources where responsibility for good outcomes is expected. Co-training of general surgeons and medical residents who can provide essential surgical call coverage may lead to on-going synergies. Teaching by medical and surgical subspecialists is essential in medical residencies to provide the depth of instruction residents need to develop as excellent clinicians. Dependable scheduling of their specialty instruction allows residency program directors to assure inclusion of their content in the residency curriculum. In summary, participants agreed that teaching in medical residency programs in LMIC present excellent opportunities for national and expat Christian physician educators

  5. Providing International Research Experiences in Water Resources Through a Distributed REU Program

    Science.gov (United States)

    Judge, J.; Sahrawat, K.; Mylavarapu, R.

    2012-12-01

    Research experiences for undergraduates offer training in problem solving and critical thinking via hands-on projects. The goal of the distributed Research Experience for Undergraduates (REU) Program in the Agricultural and Biological Engineering Department (ABE) at the University of Florida (UF) is to provide undergraduate students a unique opportunity to conduct research in water resources using interdisciplinary approaches, integrating research and extension, while the cohort is not co-located. The eight-week REU Program utilizes the extensive infrastructure of UF - Institute of Food and Agricultural Sciences (IFAS) through the Research and Education Centers (RECs). To provide international research and extension experience, two students were located at the International Crop Research Institute for the Semi-Arid Tropics (ICRISAT), in India. Prior to the beginning of the Program, the students worked closely with their research mentors at University of Florida and ICRISAT to develop a project plan for understanding the water quality issues in two watersheds. The students were co-located during the Orientation week at the University of Florida. During the Program, they achieved an enriching cohort experience through social networking, daily blogs, and weekly video conferences to share their research and other REU experiences. The group meetings and guest lectures are conducted via synchronously through video conferencing. The students who were distributed across Florida benefited from the research experiences of the students who were located in India, as their project progressed. They described their challenges and achievements during the group meetings and in the blogs. This model of providing integrated research and extension opportunities in hydrology where not all the REU participants are physically co-located, is unique and can be extended to other disciplines.

  6. Endangered species and cultural resources program, Naval Petroleum Reserves in California: Annual report FY95

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    In FY95, EG and G Energy Measurements, Inc. (EG and G/EM) continued to support efforts to protect endangered species and cultural resources at the Naval Petroleum Reserves in California (NPRC). These efforts are conducted to ensure NPRC compliance with regulations regarding the protection of listed species and cultural resources on Federal properties. Population monitoring activities are conducted annually for San Joaquin kit foxes, giant kangaroo rats, blunt-nosed leopard lizards, and Hoover`s wooly-star. To mitigate impacts of oil field activities on listed species, 674 preactivity surveys covering approximately 211 hectares (521 acres) were conducted in FY95. EG and G/EM also assisted with mitigating effects from third-party projects, primarily by conducting biological and cultural resource consultations with regulatory agencies. EG and G/EM has conducted an applied habitat reclamation program at NPRC since 1985. In FY95, an evaluation of revegetation rates on reclaimed and non-reclaimed disturbed lands was completed, and the results will be used to direct future habitat reclamation efforts at NPRC. In FY95, reclamation success was monitored on 50 sites reclaimed in 1985. An investigation of factors influencing the distribution and abundance of kit foxes at NPRC was initiated in FY94. Factors being examined include habitat disturbance, topography, grazing, coyote abundance, lagomorph abundance, and shrub density. This investigation continued in FY95 and a manuscript on this topic will be completed in FY96. Also, Eg and G/EM completed collection of field data to evaluate the effects of a well blow-out on plant and animal populations. A final report will be prepared in FY96. Finally, EG and G/EM completed a life table analysis on San Joaquin kit foxes at NPRC.

  7. Resource Contingency Program - Oregon : Final Environmental Impact Statement, Hermiston Power Project.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1995-09-01

    The Bonneville Power Administration (BPA) has statutory responsibilities to supply electrical power to its utility, industrial, and other customers in the Pacific Northwest. In 1990, to cover the outer range of potential load growth with new resources, BPA embarked upon the Resource Contingency Program (RCP). Instead of buying or building generating plants now, BPA has purchased options to acquire power later, if and when it is needed. The decision to acquire any of these option energy projects to fulfill statutory supply obligations will be influenced by Federal system load growth, the outcome of BPA`s Business Plan, required operational changes in Columbia-Snake River Hydroelectric facilities, and the loss of major generating resources. In September 1993, three option development agreements were signed with three proposed natural gas-fired, combined cycle combustion turbine CT projects near Chehalis and Satsop, Washington, and near Hermiston, Oregon. Together these three projects could supply BPA with 1,090 average megawatts (aMW) of power. Under these agreements, sponsors are obtaining permits and conducting project design work, and BPA is completing this EIS process. In September 1993, BPA published a Notice of Intent to prepare an environmental impact statement (EIS) on these three proposed gas-fired combustion turbine projects and held public scoping meetings in October 1993 at each site. In February 1994, BPA released an Implementation Plan on the proposed scope of the EIS. A draft EIS on the three proposed projects was published in February 1995. The impacts of the Chehalis and Satsop projects located in Washington State will be covered in one EIS document, while the impacts of the Hermiston project located in Oregon are covered in this final EIS document. It is BPA`s intent to continue to base the analysis of impacts on the assumption that all three projects may be constructed at some point in the future.

  8. Human resources FY 1995 Site Program Plan WBS 6.10.2

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    This document contains information concerning human resources management at the Hanford Reservation. Information discusses the following topics: Cost estimates, closure and placement of labor resources, and management of human resources throughout the Hanford Site.

  9. The National Toxicology Program Web-based nonneoplastic lesion atlas: a global toxicology and pathology resource.

    Science.gov (United States)

    Cesta, Mark F; Malarkey, David E; Herbert, Ronald A; Brix, Amy; Hamlin, Melvin H; Singletary, Emily; Sills, Robert C; Bucher, John R; Birnbaum, Linda S

    2014-01-01

    Toxicologists and pathologists worldwide will benefit from a new, website-based, and completely searchable Nonneoplastic Lesion Atlas just released by the U.S. National Toxicology Program (NTP). The atlas is a much-needed resource with thousands of high-quality, zoomable images and diagnostic guidelines for each rodent lesion. Liver, gallbladder, nervous system, bone marrow, lower urinary tract and skin lesion images, and diagnostic strategies are available now. More organ and biological systems will be added with a total of 22 chapters planned for the completed project. The atlas will be used by the NTP and its many pathology partners to standardize lesion diagnosis, terminology, and the way lesions are recorded. The goal is to improve our understanding of nonneoplastic lesions and the consistency and accuracy of their diagnosis between pathologists and laboratories. The atlas is also a useful training tool for pathology residents and can be used to bolster any organization's own lesion databases. Researchers have free access to this online resource at www.ntp.niehs.nih.gov/nonneoplastic.

  10. A genome resource to address mechanisms of developmental programming: determination of the fetal sheep heart transcriptome.

    Science.gov (United States)

    Cox, Laura A; Glenn, Jeremy P; Spradling, Kimberly D; Nijland, Mark J; Garcia, Roy; Nathanielsz, Peter W; Ford, Stephen P

    2012-06-15

    The pregnant sheep has provided seminal insights into reproduction related to animal and human development (ovarian function, fertility, implantation, fetal growth, parturition and lactation). Fetal sheep physiology has been extensively studied since 1950, contributing significantly to the basis for our understanding of many aspects of fetal development and behaviour that remain in use in clinical practice today. Understanding mechanisms requires the combination of systems approaches uniquely available in fetal sheep with the power of genomic studies. Absence of the full range of sheep genomic resources has limited the full realization of the power of this model, impeding progress in emerging areas of pregnancy biology such as developmental programming. We have examined the expressed fetal sheep heart transcriptome using high-throughput sequencing technologies. In so doing we identified 36,737 novel transcripts and describe genes, gene variants and pathways relevant to fundamental developmental mechanisms. Genes with the highest expression levels and with novel exons in the fetal heart transcriptome are known to play central roles in muscle development. We show that high-throughput sequencing methods can generate extensive transcriptome information in the absence of an assembled and annotated genome for that species. The gene sequence data obtained provide a unique genomic resource for sheep specific genetic technology development and, combined with the polymorphism data, augment annotation and assembly of the sheep genome. In addition, identification and pathway analysis of novel fetal sheep heart transcriptome splice variants is a first step towards revealing mechanisms of genetic variation and gene environment interactions during fetal heart development.

  11. [Validation of the structure and resources of nosocomial infection control team in hospitals ascribed to VINCat program in Catalonia, Spain].

    Science.gov (United States)

    Limón, Enrique; Pujol, Miquel; Gudiol, Francesc

    2014-07-01

    The main objective of this study was to validate the structure of the infection control team (ICT) in the hospitals adhered to VINCat program and secondary objective was to establish the consistency of resources of each center with the requirements established by the program. Qualitative research consisting of an ethnographic study using participant observation during the years 2008-2010. The centers were stratified in three groups by complexity and beds. The instrument was a semistructured interview to members of the ICT. The transcription of the interview was sent to informants for validation. In November 2010 a questionnaire regarding human resources and number hours dedicated to the ICT was sent. During 2008-2010, 65 centers had been adhered to VINCat program. In 2010, the ICT of Group I hospitals had a mean of two physician, one in full-time and one nurse for every 230 beds. In Group II, one physician part-time and one nurse per 180 beds and in Group III a physician and a nurse for every 98 beds, both part-time. In 2010, all hospitals had a structured ICT, an operative infection committee, and a hospital member representing the center at the program as well as enough electronic resources. The hospitals participating in the program have now VINCat an adequate surveillance structure and meet the minimum technical and human resources required to provide high-quality data. However human resources are not guaranteed. Copyright © 2014. Published by Elsevier Espana.

  12. Proposed program for and present status of the Geological Survey's investigation of domestic resources of radioactive raw materials

    Science.gov (United States)

    Bulter, A.P.; Killeen, P.L.; Page, G.B.; Rubey, W.W.

    1983-01-01

    This interim report is designed to show the present status of the Geological Survey's information and the parts of a comprehensive program necessary to improve our information about the raw material resources of uranium and thorium. Rarely in geologic work has it been necessary. to determine so completely a nation's resources of useful minerals in so brief a span of time. Ordinarily, information on mineral resources Is accumulated during a long period of years. However, uranium and thorium were suddenly thrust from a position of subsidiary economic interest into one of great strategic importance. Information concerning their occurrence must, therefore, be obtained as rapidly as reliable methods of investigation will permit. Accordingly the program must be at once comprehensive and carried out over an area more extensive than is usual in the search for and appraisal of most other mineral resources.

  13. A Genotype Resource for Postmortem Brain Samples from the Autism Tissue Program

    Science.gov (United States)

    Wintle, Richard F.; Lionel, Anath C.; Hu, Pingzhao; Ginsberg, Stephen D.; Pinto, Dalila; Thiruvahindrapduram, Bhooma; Wei, John; Marshall, Christian R.; Pickett, Jane; Cook, Edwin H.; Scherer, Stephen W.

    2015-01-01

    The Autism Tissue Program (ATP), a science program of Autism Speaks, provides researchers with access to well-characterized postmortem brain tissues. Researchers access these tissues through a peer-reviewed, project-based approval process, and obtain related clinical information from a secure, online informatics portal. However, few of these samples have DNA banked from other sources (such as a blood sample from the same individual), hindering genotype–phenotype correlation and interpretation of gene expression data derived fromthe banked brain tissue. Here, we describe an initiative to extract DNA from Brodmann Area 19, and genotype these samples using both the Affymetrix Genome-Wide Human SNP Array 6.0 and the Illumina Human1M-Duo DNA Analysis BeadChip genome-wide microarray technologies. We additionally verify reported gender, and infer ethnic background from the single nucleotide polymorphism data. We have also used a rigorous, multiple algorithm approach to identify genomic copy number variation (CNV) from these array data. Following an initial proof of principle study using two samples, 52 experimental samples, consisting of 27 subjects with confirmed or suspected autism and related disorders, 5 subjects with cytogenetically visible duplications of 15q, 2 with epilepsy and 18 age-matched normal controls were processed, yielding high-quality genotype data in all cases. The genotype and CNV data are provided via the ATP informatics portal as a resource for the autism research community. PMID:21254448

  14. Endangered species and cultural resources program, Naval Petroleum Reserves in California, annual report FY97

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-05-01

    The Naval Petroleum Reserves in California (NPRC) are oil fields administered by the DOE in the southern San Joaquin Valley of California. Four federally endangered animal species and one federally threatened plant species are known to occur on NPRC: San Joaquin kit fox (Vulpes macrotis mutica), blunt-nosed leopard lizard (Gambelia silus), giant kangaroo rat (Dipodomys ingens), Tipton kangaroo rat (Dipodomys nitratoides), and Hoover`s wooly-star (Eriastrum hooveri). All five are protected under the Endangered Species Act (ESA) of 1973. The DOE/NPRC is obliged to determine whether actions taken by their lessees on Naval Petroleum Reserve No. 2 (NPR-2) will have any effects on endangered species or their habitats. The primary objective of the Endangered Species and Cultural Resources Program is to provide NPRC with the scientific expertise necessary for compliance with the ESA, the National Environmental Policy Act (NEPA), and the National Historic Preservation Act (NHPA). The specific objective of this report is to summarize progress, results, and accomplishments of the program during fiscal year 1997 (FY97).

  15. Integrating Research and Extension for the Nsf-Reu Program in Water Resources

    Science.gov (United States)

    Judge, J.; Migliaccio, K.; Gao, B.; Shukla, S.; Ehsani, R.; McLamore, E.

    2011-12-01

    Providing positive and meaningful research experiences to students in their undergraduate years is critical for motivating them to pursue advanced degrees or research careers in science and engineering. Such experiences not only offer training for the students in problem solving and critical thinking via hands-on projects, but also offer excellent mentoring and recruiting opportunities for the faculty advisors. The goal of the Research Experience for Undergraduates (REU) Program in the Agricultural and Biological Engineering Department (ABE) at the University of Florida (UF) is to provide eight undergraduate students a unique opportunity to conduct research in water resources using interdisciplinary approaches, integrating research and extension. The students are selected from diverse cultural and educational backgrounds. The eight-week REU Program utilizes the extensive infrastructure of UF - Institute of Food and Agricultural Sciences (IFAS) through the Research and Education Centers (RECs). Two students are paired to participate in their own project under the direct supervision of one of the four research mentors. Four of the eight students are located at the main campus, in Gainesville, Fl, and four remaining students are located off-campus, at the RECs, where some of the ABE faculty are located. The students achieve an enriching cohort experience through social networking, daily blogs, and weekly video conferences to share their research and other REU experiences. The students are co-located during the Orientation week and also during the 5-day Florida Waters Tour. Weekly group meetings and guest lectures are conducted via synchronously through video conferencing. The integration of research and extension is naturally achieved through the projects at the RECs, the guest lectures, Extension workshops, and visits to the Water Management Districts in Florida. In the last two years of the Program, we have received over 80 applicants, from four-year and advanced

  16. Zanthoxylum ailanthoides Suppresses Oleic Acid-Induced Lipid Accumulation through an Activation of LKB1/AMPK Pathway in HepG2 Cells

    Directory of Open Access Journals (Sweden)

    Eun-Bin Kwon

    2018-01-01

    Full Text Available Zanthoxylum ailanthoides (ZA has been used as folk medicines in East Asian and recently reported to have several bioactivity; however, the studies of ZA on the regulation of triacylglycerol (TG biosynthesis have not been elucidated yet. In this study, we examined whether the methanol extract of ZA (ZA-M could reduce oleic acid- (OA- induced intracellular lipid accumulation and confirmed its mode of action in HepG2 cells. ZA-M was shown to promote the phosphorylation of AMPK and its upstream LKB1, followed by reduction of lipogenic gene expressions. As a result, treatment of ZA-M blocked de novo TG biosynthesis and subsequently mitigated intracellular neutral lipid accumulation in HepG2 cells. ZA-M also inhibited OA-induced production of reactive oxygen species (ROS and TNF-α, suggesting that ZA-M possess the anti-inflammatory feature in fatty acid over accumulated condition. Taken together, these results suggest that ZA-M attenuates OA-induced lipid accumulation and inflammation through the activation of LKB1/AMPK signaling pathway in HepG2 cells.

  17. Hydrogen-rich medium protects mouse embryonic fibroblasts from oxidative stress by activating LKB1-AMPK-FoxO1 signal pathway.

    Science.gov (United States)

    Lee, Jihyun; Yang, Goowon; Kim, Young-Joo; Tran, Quynh Hoa; Choe, Wonchae; Kang, Insug; Kim, Sung Soo; Ha, Joohun

    2017-09-23

    Persistent oxidative stress is recognized as a major cause of many pathological conditions as well as ageing. However, most clinical trials of dietary antioxidants have failed to produce successful outcomes in treating oxidative stress-induced diseases. Molecular hydrogen (H 2 ) has recently received considerable attention as a therapeutic agent owing to its novel antioxidant properties, a selective scavenger of hydroxyl and peroxynitrite radicals. Beyond this, numerous reports support that H 2 can modulate the activity of various cellular signal pathways. However, its effect on AMP-activated protein kinase (AMPK) signal pathway, a central regulator of energy hemostasis, has remained almost elusive. Here, we report that hydrogen-rich medium activated LKB1-AMPK signal pathway without ATP depletion, which in turn induced FoxO1-dependent transcription of manganese superoxide dismutase and catalase in mouse embryonic fibroblasts. Moreover, hydrogen-rich media effectively reduced the level of reactive oxygen species in cells treated with hydrogen peroxide and protected these cells from apoptosis in an AMPK-dependent manner. These results suggest that the LKB1-AMPK-FoxO1 signaling pathway is a critical mediator of the antioxidant properties of H 2 , further supporting the idea that H 2 acts as a signaling molecule to serve various physiological functions. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Ethanol Extract of Pinus koraiensis Leaf Ameliorates Alcoholic Fatty Liver via the Activation of LKB1-AMPK Signaling In Vitro and In Vivo.

    Science.gov (United States)

    Hong, Sang-Hyuk; Lee, Hyemin; Lee, Hyo-Jung; Kim, Bonglee; Nam, Min-Ho; Shim, Bum-Sang; Kim, Sung-Hoon

    2017-05-01

    Although Pinus koraiensis leaf (PKL) was reported for its anti-diabetes, anti-obesity and anticancer effects as a folk remedy, the inhibitory effect of PKL on alcoholic fatty liver has never been elucidated yet. This study investigated the molecular mechanisms of PKL on alcoholic fatty liver in HepG2 cells, Sprague Dawley (SD) rats and Imprinting Control Region (ICR) mice. Pinus koraiensis leaf increased phosphorylation of liver kinase B1 (LKB1)/AMP-activated protein kinase signaling, low-density lipoprotein receptor and decreased fatty acid biosynthesis-related proteins such as sterol regulatory element-binding protein 1c, fatty acid synthase, 3-hydroxy-3-methylglutaryl-CoA reductase in HepG2 cells. In SD rats with 25% alcohol-induced fatty liver, PKL suppressed the levels of aspartate aminotransferase and triglyceride and also enhanced the activities of antioxidant enzymes including superoxide dismutase, glutathione peroxidase and glutathione s-transferase compared with untreated control. Furthermore, PKL increased serum alcohol dehydrogenase and serum aldehyde dehydrogenase, but decreased serum alcohol concentration in ICR mice after alcohol administration. Consistently, histochemical analysis revealed that PKL attenuated alcohol-induced fatty liver in SD rats. Overall, these findings suggest that PKL ameliorates alcohol-induced fatty liver via activation of LKB1-AMP-activated protein kinase and modulation of proteins related to lipogenesis synthesis, cholesterol synthesis and fatty acid oxidation. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  19. LKB1/PEA3/ΔNp63 Pathway Regulates PTGS-2 (COX-2 Transcription in Lung Cancer Cells Upon Cigarette Smoke Exposure

    Directory of Open Access Journals (Sweden)

    Edward A. Ratovitski

    2010-01-01

    Full Text Available This is the first study to show that cigarette smoking induced the LKB1/PEA 3/ΔNp63-dependent transcriptional regulation of inflammatory molecules, such as COX-2/PTGS-2. Using mainstream smoke extract (MSE and sidestream smoke extract (SSE as modeling tools for primary and secondhand smoking, we found that both MSE and SSE downregulated protein levels for LKB1, while upregulated protein levels for PEA 3 and COX-2 in a dose-dependent manner. Using the endogenous ChIP analysis, we further found that the C/EBPβ, NFκB, NF-Y (CHOP, PEA 3 (ETS and ΔNp63 proteins bound to the specific area (-550 to -130 of the COX-2 promoter, while forming multiple protein complexes in lung cancer cells exposed to MSE and SSE. Our results define a novel link between various transcription factors occupying the COX-2 promoter and cellular response to cigarette smoke exposure bringing a new component, ΔNp63α, showing a critical role for cooperation between various chromatin components in regulation of COX-2 expression and, therefore strengthening the central role of inflammatory process in tumorigenesis of epithelial cells, especially after cigarette smoke exposure (both primary and secondhand.

  20. SPA AND CLIMATIC RESORTS (CENTERS AS RESOURCES OF PROGRAM OF SPORT RECREATION IMPLEMENTATION

    Directory of Open Access Journals (Sweden)

    Ivica Nikolić

    2006-06-01

    Full Text Available The aspiration of the civilized man is the improvement of work which aim is to achieve as big as possible effect of productivity and as small as possible participation of labour. The result of this process, which cannot be avoided, is some kind of fatigue that has hypocinaesiological characteristics in regard to demands of modern work process. The most effective way to fight against fatigue is to have an active holiday that is meaningfully programmed, led and carried out through movement of tourists, with the addition of natural factors, among which climate and healing waters are particularly important. These very resources characterize the tourist potential of Serbia and Montenegro with lots of available facilities at 1000 m height above the sea level and spa centers with springs and a complete offer physio-prophylactic procedures and following facilities for sport recreation. The implementation of programmed active holidays in to the corpus of tourist offer of Serbia and Montenegro represents prospective of development of tourism and tourist economy with effects of multiple importance as for participants, so for the level of tourist consumption. That will definitely influence the lengthening of tourist season as the primary goal of every catering establishment. Surveys show that the affection and viewpoints of potential tourists are especially directed towards engaging sport games and activities on and in the water, as part of the elementary tourist offer in spas and climatic resorts and their available facilities. Recommendationsand postulates of program of sport recreation, which are presented through four charts, are the basis of marketing strategy of appearance on tourist market with permanent education of management personnel and further research of potential market expanding. The publication and distribution of advertising materials are especially important, both at the market in our country and at the foreign market, where the abundance

  1. The human resource management contribute six sigma program: multiple-case study in companies situated in Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Jaqueline T. M. Corrêa Rodrigues

    2011-09-01

    Full Text Available The world is going through rapid changes and the companies seek alternatives to improve its products and processes and maintain their competitiveness. One alternative is the implementation of programs of quality management that combine human’s and technical’s factors. Six Sigma has gained evidence on the last years because aggregate tools and methodology. However, all quality program factors need management. The main goal of this paper is classify what assignments of Human Resource Management can contribute to reduction of the difficulties that can be encountered on implementation and maintenance of Six Sigma program in companies that was situated in the Rio Grande do Sul. For carry this work was necessary contact companies of the Rio Grande do Sul that use this program and was applied one questionnaire to classify the contribution of the Human Resource Management for the success of Six Sigma. The statistical tools, contents analyze, tables of relationship and qualitative analysis were applied for analysis. It’s evidence in this research the existence of potentials difficulties of Six Sigma listed in the literature and the influence that some assignments of Human Resource Management can be for solve this difficulties. The result of the research indicate that the participative and compromised leadership and the clear and objective communication of program are the assignments of Human Resource Management among the studied that more contribute for reduction of the difficulties of Six Sigma in the companies of this research.

  2. The National Animal Germplasm Program: challenges and opportunities for poultry genetic resources.

    Science.gov (United States)

    Blackburn, H D

    2006-02-01

    In the United States, poultry genetic resources have consolidated because of economic pressures. Such consolidations can potentially jeopardize the poultry industry and the ability of research communities to respond to future challenges. To address the loss of genetic resources for all livestock and aquatic species, USDA established the National Animal Germplasm Program (NAGP) in 1999. Since the initiation of NAGP, population surveys have been conducted on nonindustrial chicken and turkey breeds. These surveys not only provide insight into breed status, but also serve as a benchmark for future comparisons. The survey results revealed that 20 chicken breeds and 9 turkey breeds were in various stages of being lost. The NAGP has initiated an ex situ repository for cryopreserved germplasm and tissue that already contains 59 chicken lines and 2,915 tissue samples. As the NAGP, along with its industry and university partners, continues developing the ex situ collection, there are research opportunities in cryopreserved tissue utilization and studies of genetic diversity. For cryopreserved tissues, several key research areas include improving the cryopreservation protocols for rooster and tom semen by using cryoprotectants other than glycerol and utilizing embryonic cells. Although surveys have been conducted on public research lines and rare breeds, there is a void in understanding the level of genetic diversity present in U.S. poultry populations. Therefore, an opportunity exists to perform a series of genetic diversity studies using molecular- based approaches. Such an evaluation can help clarify population differences between research lines and rare breeds and, thereby, facilitate conservation strategies. There appears to be growing consumer interest in poultry products derived from heritage breeds and/or poultry raised in nonindustrial production systems. Although the depth of such market trends is unknown, such an interest may provide an important niche for rare

  3. Development of a comprehensive and sustainable gynecologic oncology training program in western Kenya, a low resource setting

    Directory of Open Access Journals (Sweden)

    Barry Rosen

    2017-08-01

    This is the first recognized fellowship training program in sub-Saharan Africa outside of South Africa. It is an example of a collaborative effort to improve women's health in a low-resource country. This is a Kenyan managed program through Moi University. These subspecialty trained doctors will also provide advice that will shape health care policy and provide sustainable expertise for women diagnosed with a gynecologic cancer.

  4. The BRIGHTEN Program: Implementation and Evaluation of a Program to Bridge Resources of an Interdisciplinary Geriatric Health Team via Electronic Networking

    Science.gov (United States)

    Emery, Erin E.; Lapidos, Stan; Eisenstein, Amy R.; Ivan, Iulia I.; Golden, Robyn L.

    2012-01-01

    Purpose: To demonstrate the feasibility of the BRIGHTEN Program (Bridging Resources of an Interdisciplinary Geriatric Health Team via Electronic Networking), an interdisciplinary team intervention for assessing and treating older adults for depression in outpatient primary and specialty medical clinics. The BRIGHTEN team collaborates "virtually"…

  5. Using Innovative Resources and Programs to Prepare Pre- and In-Service Teachers for New Science Standards

    Science.gov (United States)

    Kinzler, R. J.; Short, J.; Contino, J.; Cooke-Nieves, N.; Howes, E.; Kravitz, D.; Randle, D.; Trowbridge, C.

    2014-12-01

    Leveraging the Rose Center for Earth and Space and active research departments in Earth and Planetary Science, Astrophysics, and Paleontology, the Education Department at the American Museum of Natural History (AMNH) offers an MAT program to prepare new Earth Science teachers (~100 new teachers by 2018) as well as a range of professional development (PD) opportunities for over 3,000 K-12 teachers annually, providing opportunities to learn with scientists; inquiry-based experiences; and standards-aligned resources. The AMNH produces innovative geoscience and other STEM resources supporting teacher and student science investigations with data visualizations and analysis tools, teaching case materials and other resources that provide rich nonfiction reading and writing opportunities for use in Earth and space science curricula that are integrated in the MAT and PD programs. Museum resources and the MAT and PD programs are aligned to support the recently released Next Generation Science Standards (NGSS) and the Common Core State Standards. The NGSS is a set of science and engineering practices, crosscutting concepts and disciplinary core ideas to help cultivate teachers' and K-12 students' scientific habits of mind, develop their knowledge and abilities to engage in scientific investigations, and teach them how to reason in context; goals that closely align with those of the AMNH's teacher preparation and professional development programs. A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas (NRC, 2012) is a required text for the MAT program, and this text as well as the NGSS Performance Expectations guide the PD programs as well. Researchers working with Museum scientists and educators find it is not enough for programs for pre- and in-service teachers to provide access to resources. Research suggests that these programs need to engage pre- and in-service teachers in using and reflecting on these types of resources, as well as take

  6. Landholder Profiling and Typologies for Natural Resource-Management Policy and Program Support: Potential and Constraints

    Science.gov (United States)

    Emtage, Nick; Herbohn, John; Harrison, Steve

    2007-09-01

    The use of landholder typologies to aid the development, implementation, and monitoring natural-resource management (NRM) policies and programs has increased considerably during the past decade. This article explores the potential for using such typologies for a variety of NRM and rural and regional development applications. Review of typology use further suggests that there is potential to refine the way that typologies are developed and applied to better aid NRM, farming systems analyses, and rural and regional development. Before typologies will be adopted more widely, a number of theoretical and methodologic issues must be addressed. These include the following questions: (1) Which criteria and methods should or can be used to classify landholders? (2) How should studies across spatial and temporal scales be integrated? (3) How should multiple and single industry studies be integrated to gain the most value from research? We argue that quantitative research techniques are well suited to provide an underlying structure for landholder typologies, and qualitative research techniques are useful for developing understanding of the nature of variation within and between landholder types. We argued further that because of the potential utility and breadth for the application of landholder typologies, a nested set of landholder typologies could be developed that are coordinated at the national, regional, and local geographic levels, with repeated measures used to track the evolution with time of landholder practices, management values, and socioeconomic characteristics.

  7. Helping patients with diabetes: resources from the National Diabetes Education Program.

    Science.gov (United States)

    Rodgers, Philip T

    2012-01-01

    To familiarize pharmacists with the National Diabetes Education Program (NDEP) and to demonstrate the value of NDEP materials in the care of patients with diabetes. The NDEP website (www.ndep.nih.gov) and PubMed (www.ncbi.nlm.nih.gov/pubmed). NDEP is a collaboration between the National Institutes of Health, Centers for Disease Control and Prevention, and many organization partners. Since 1997, a large number of materials have been created by NDEP using an evidence-based, expert- and patient-reviewed approach to development. Materials are nonbranded and reflect current medical knowledge and practice. Educational materials are available for persons at risk for diabetes, those with diabetes, family members of persons with diabetes, employers, and professionals. The Pharmacy, Podiatry, Optometry, and Dentistry (PPOD) workgroup of NDEP promotes the value of pharmacists and other professionals in diabetes education and management. Resources are available to educate about the value of the PPOD professionals. NDEP provides evidence-based, high-quality educational materials that pharmacists will find useful in the counseling of persons with diabetes.

  8. The US Support Program to IAEA Safeguards Priority of Training and Human Resources

    Energy Technology Data Exchange (ETDEWEB)

    Queirolo,A.

    2008-06-13

    The U.S. Support Program to IAEA Safeguards (USSP) priority of training and human resources is aimed at providing the Department of Safeguards with an appropriate mixture of regular staff and extrabudgetary experts who are qualified to meet the IAEA's technical needs and to provide personnel with appropriate instruction to improve the technical basis and specific skills needed to perform their job functions. The equipment and methods used in inspection activities are unique, complex, and evolving. New and experienced safeguards inspectors need timely and effective training to perform required tasks and to learn new skills prescribed by new safeguards policies or agreements. The role of the inspector has changed from that of strictly an accountant to include that of a detective. New safeguards procedures are being instituted, and therefore, experienced inspectors must be educated on these new procedures. The USSP also recognizes the need for training safeguards support staff, particularly those who maintain and service safeguards equipment (SGTS), and those who perform information collection and analysis (SGIM). The USSP is committed to supporting the IAEA with training to ensure the effectiveness of all staff members and will continue to offer its assistance in the development and delivery of basic, refresher, and advanced training courses. This paper will discuss the USSP ongoing support in the area of training and IAEA staffing.

  9. Interval multistage joint-probabilistic integer programming approach for water resources allocation and management.

    Science.gov (United States)

    Gu, J J; Huang, G H; Guo, P; Shen, N

    2013-10-15

    In this study, an interval multistage joint-probabilistic integer programming method was developed to address certain problems in water resource regulation. This method effectively deals with data in the form of intervals and probability distribution. It can also process uncertain data in the form of joint probabilities. The proposed method can also reflect the linkage and dynamic variability between particular stages in multi-stage planning. Sensitivity analysis on moderate violations and security constraints showed that the degree of constraint violation was closely linked to the final benefits of the system. The developed method was applied in the case study of the joint-operation of the Tianzhuang and Bashan Reservoirs in Huaihe River, China. In this case study, the proposed method can deal with the water shortage problems downstream and the distribution problems caused by excess water in the reservoir. It can also guarantee the optimization of long-term water usage of both Reservoirs and the river downstream. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Social and economic research program for the Geysers-Calistoga known geothermal resource area

    Energy Technology Data Exchange (ETDEWEB)

    Hall, C.; O' Banion, K.

    1979-03-27

    The purpose of this study is to assess the economic and social effects of projected geothermal resource development for both direct use and electric power generation and to analyze local regulatory policy options designed to mitigate adverse effects. The key issues are land use, fiscal and public infrastructure systems, demography, and the local economy. The study has seven elements: a computer-based inventory and analysis of land characteristics, constraints, sensitivity, and suitability for various land uses; projections of direct and electric geothermal development; primary and induced economic activity using an input-output model; demographic changes; the land and infrastructural demand created; an assessment of the economic and social effects of various configurations in land use that could result; and an analysis of various local regulatory policy options to mitigate adverse effects. The study is a cooperative effort among two national laboratories, a regional agency, and the four Geysers-area counties (Lake, Mendocino, Napa, and Sonoma). The assessment results are intended to guide Department of Energy planners on the environmental consequences of program implementation. The regulatory policy analysis is intended for local officials who are implementing development-management policy.

  11. HANFORD TANK FARM RESOURCE CONVERVATION & RECOVERY ACT (RCRA) CORRECTIVE ACTION PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    KRISTOFZSKI, J.G.

    2007-01-15

    As a consequence of producing special nuclear material for the nation's defense, large amounts of extremely hazardous radioactive waste was created at the US Department of Energy's (DOE) Hanford Site in south central Washington State. A little over 50 million gallons of this waste is now stored in 177 large, underground tanks on Hanford's Central Plateau in tank farms regulated under the Atomic Energy Act and the Resource, Conservation, and Recovery Act (RCRA). Over 60 tanks and associated infrastructure have released or are presumed to have released waste in the vadose zone. In 1998, DOE's Office of River Protection established the Hanford Tank Farm RCRA Corrective Action Program (RCAP) to: (1) characterize the distribution and extent of the existing vadose zone contamination; (2) determine how the contamination will move in the future; (3) estimate the impacts of this contamination on groundwater and other media; (4) develop and implement mitigative measures; and (5) develop corrective measures to be implemented as part of the final closure of the tank farm facilities. Since its creation, RCAP has made major advances in each of these areas, which will be discussed in this paper.

  12. Gulf Coast geopressured-geothermal program summary report compilation. Volume 3: Applied and direct uses, resource feasibility, economics

    Energy Technology Data Exchange (ETDEWEB)

    John, C.J.; Maciasz, G.; Harder, B.J.

    1998-06-01

    The US Department of Energy established a geopressured-geothermal energy program in the mid 1970`s as one response to America`s need to develop alternate energy resources in view of the increasing dependence on imported fossil fuel energy. This program continued for 17 years and approximately two hundred million dollars were expended for various types of research and well testing to thoroughly investigate this alternative energy source. This volume describes the following studies: Geopressured-geothermal hybrid cycle power plant: design, testing, and operation summary; Feasibility of hydraulic energy recovery from geopressured-geothermal resources: economic analysis of the Pelton turbine; Brine production as an exploration tool for water drive gas reservoirs; Study of supercritical Rankine cycles; Application of the geopressured-geothermal resource to pyrolytic conversion or decomposition/detoxification processes; Conclusions on wet air oxidation, pyrolytic conversion, decomposition/detoxification process; Co-location of medium to heavy oil reservoirs with geopressured-geothermal resources and the feasibility of oil recovery using geopressured-geothermal fluids; Economic analysis; Application of geopressured-geothermal resources to direct uses; Industrial consortium for the utilization of the geopressured-geothermal resource; Power generation; Industrial desalination, gas use and sales, pollutant removal, thermal EOR, sulfur frasching, oil and natural gas pipelining, coal desulfurization and preparation, lumber and concrete products kilning; Agriculture and aquaculture applications; Paper and cane sugar industries; Chemical processing; Environmental considerations for geopressured-geothermal development. 27 figs., 25 tabs.

  13. Scheduling Parallel Jobs with Time-Resource Tradeoff via Nonlinear Programming

    NARCIS (Netherlands)

    Grigoriev, A.; Uetz, Marc Jochen

    We consider a scheduling problem where the processing time of any job is dependent on the usage of a discrete renewable resource, e.g. personnel. An amount of $k$ units of that resource can be allocated to the jobs at any time, and the more of that resource is allocated to a job, the smaller its

  14. Photographic consulting services to the Earth Resources program. [using aerial photography as a tool for scientific measurement

    Science.gov (United States)

    1976-01-01

    The recommendations, procedures, and techniques are summarized which provided by the Kodak Apparatus Division to the Ames Research Center to support the Earth Resources Aircraft Program at that facility. Recommendations, procedures, and calibration data are included for sensitometry, densitometry, laboratory cleanliness, and determination of camera exposure. Additional comments are made regarding process control procedures and general laboratory operations.

  15. Technical-Oriented Enterprise Resource Planning (ERP) Body of Knowledge for Information Systems Programs: Content and Implementation

    Science.gov (United States)

    Boyle, Todd A.

    2007-01-01

    In this article, the author proposes a body of knowledge that the educators can use to incorporate the technical aspects of enterprise resource planning (ERP) into an information systems (IS) program, encapsulated as the ERP technical knowledge framework. To illustrate the application of this framework, the author discusses a course sequence that…

  16. The Effectiveness of Distance Education, Using Blended Method of Delivery for Limited-Resource Audiences in the Nutrition Education Program

    Science.gov (United States)

    Campbell, Casey; Koszewski, Wanda M.; Behrends, Donnia

    2013-01-01

    The study reported here sought to determine if the use of distance education lessons for teaching limited resource participants in a nutrition education program (NEP) is as effective as face-to-face methodology. One hundred and six participants were in the experimental group. Data was gathered at entry and examined behavior change, nutrient intake…

  17. Hydrologic Resources Management Program and Underground Test Area Project FY 2006 Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Culham, H W; Eaton, G F; Genetti, V; Hu, Q; Kersting, A B; Lindvall, R E; Moran, J E; Blasiyh Nuno, G A; Powell, B A; Rose, T P; Singleton, M J; Williams, R W; Zavarin, M; Zhao, P

    2008-04-08

    This report describes FY 2006 technical studies conducted by the Chemical Biology and Nuclear Science Division (CBND) at Lawrence Livermore National Laboratory (LLNL) in support of the Hydrologic Resources Management Program (HRMP) and the Underground Test Area Project (UGTA). These programs are administered by the U.S. Department of Energy, National Nuclear Security Administration, Nevada Site Office (NNSA/NSO) through the Defense Programs and Environmental Restoration Divisions, respectively. HRMP-sponsored work is directed toward the responsible management of the natural resources at the Nevada Test Site (NTS), enabling its continued use as a staging area for strategic operations in support of national security. UGTA-funded work emphasizes the development of an integrated set of groundwater flow and contaminant transport models to predict the extent of radionuclide migration from underground nuclear testing areas at the NTS. The report is organized on a topical basis and contains four chapters that highlight technical work products produced by CBND. However, it is important to recognize that most of this work involves collaborative partnerships with the other HRMP and UGTA contract organizations. These groups include the Energy and Environment Directorate at LLNL (LLNL-E&E), Los Alamos National Laboratory (LANL), the Desert Research Institute (DRI), the U.S. Geological Survey (USGS), Stoller-Navarro Joint Venture (SNJV), and National Security Technologies (NSTec). Chapter 1 is a summary of FY 2006 sampling efforts at near-field 'hot' wells at the NTS, and presents new chemical and isotopic data for groundwater samples from four near-field wells. These include PM-2 and U-20n PS 1DDh (CHESHIRE), UE-7ns (BOURBON), and U-19v PS No.1ds (ALMENDRO). Chapter 2 is a summary of the results of chemical and isotopic measurements of groundwater samples from three UGTA environmental monitoring wells. These wells are: ER-12-4 and U12S located in Area 12 on Rainier

  18. Four Generations of Maintenance Resource Management Programs in the United States: An Analysis of the Past, Present, and Future

    Science.gov (United States)

    Taylor, James C.; Patankar, Manoj S.

    2001-01-01

    This paper analyzes four generations of Maintenance Resource Management (MRM) programs implemented by aviation maintenance organizations in the United States. Data collected from over ten years of survey research and field observations are used for this analysis; they are presented in a case-study format. The first three generations of MRM programs were episodic efforts to increase safety through teamwork, focus group discussions, and awareness courses, respectively. Now, the fourth generation programs, characterized by a commitment to long-term communication and behavioral changes in maintenance, are set to build on those earlier generations, toward a culture of mutual trust between mechanics, their managers, and regulators.

  19. An inexact mixed risk-aversion two-stage stochastic programming model for water resources management under uncertainty.

    Science.gov (United States)

    Li, W; Wang, B; Xie, Y L; Huang, G H; Liu, L

    2015-02-01

    Uncertainties exist in the water resources system, while traditional two-stage stochastic programming is risk-neutral and compares the random variables (e.g., total benefit) to identify the best decisions. To deal with the risk issues, a risk-aversion inexact two-stage stochastic programming model is developed for water resources management under uncertainty. The model was a hybrid methodology of interval-parameter programming, conditional value-at-risk measure, and a general two-stage stochastic programming framework. The method extends on the traditional two-stage stochastic programming method by enabling uncertainties presented as probability density functions and discrete intervals to be effectively incorporated within the optimization framework. It could not only provide information on the benefits of the allocation plan to the decision makers but also measure the extreme expected loss on the second-stage penalty cost. The developed model was applied to a hypothetical case of water resources management. Results showed that that could help managers generate feasible and balanced risk-aversion allocation plans, and analyze the trade-offs between system stability and economy.

  20. Resource allocation within the National AIDS Control Program of Pakistan: a qualitative assessment of decision maker's opinions

    Directory of Open Access Journals (Sweden)

    Kadir Masood

    2007-01-01

    Full Text Available Abstract Background Limited resources, whether public or private, demand prioritisation among competing needs to maximise productivity. With a substantial increase in the number of reported HIV cases, little work has been done to understand how resources have been distributed and what factors may have influenced allocation within the newly introduced Enhanced National AIDS Control Program of Pakistan. The objective of this study was to identify perceptions of decision makers about the process of resource allocation within Pakistan's Enhanced National AIDS Control Program. Methods A qualitative study was undertaken and in-depth interviews of decision makers at provincial and federal levels responsible to allocate resources within the program were conducted. Results HIV was not considered a priority issue by all study participants and external funding for the program was thought to have been accepted because of poor foreign currency reserves and donor agency influence rather than local need. Political influences from the federal government and donor agencies were thought to manipulate distribution of funds within the program. These influences were thought to occur despite the existence of a well-laid out procedure to determine allocation of public resources. Lack of collaboration among departments involved in decision making, a pervasive lack of technical expertise, paucity of information and an atmosphere of ad hoc decision making were thought to reduce resistance to external pressures. Conclusion Development of a unified program vision through a consultative process and advocacy is necessary to understand goals to be achieved, to enhance program ownership and develop consensus about how money and effort should be directed. Enhancing public sector expertise in planning and budgeting is essential not just for the program, but also to reduce reliance on external agencies for technical support. Strengthening available databases for effective

  1. Internal Medicine Residency Program in Guyana: A Collaborative Model for Sustainable Graduate Medical Education in Resource-Limited Settings.

    Science.gov (United States)

    Persaud, Dev; Cole, Joanna; Jainarine, Ramdeo; Khalid, Zahira

    2017-01-01

    The Georgetown Public Hospital Corporation (GPHC) started the Internal Medicine/Infectious Diseases residency program in 2013. It was a collaborative initiative between GPHC and University of Maryland. Since that time the program has gone through many trials and developed new partnerships and collaboration and emerged as a young successful program with close international links that have worked and persevered in developing the successful academic and professional careers of its residents. International collaborations have resulted in applying innovative methods of teaching to deliver the curriculum in a sustainable manner in a resource-limited setting. The article discusses in detail the history of the program and the roles that the collaborative partners have played in the evolution of the program.

  2. Hydrologic Resources Management Program and Underground Test Area Project FY 2001-2002 Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Rose, T P; Kersting, A B; Harris, L J; Hudson, G B; Smith, D K; Williams, R W; Loewen, D R; Nelson, E J; Allen, P G; Ryerson, F J; Pawloski, G A; Laue, C A; Moran, J E

    2003-08-15

    This report contains highlights of FY 2001 and 2002 technical studies conducted by the Analytical and Nuclear Chemistry Division (ANCD) at Lawrence Livermore National Laboratory (LLNL) in support of the Hydrologic Resources Management Program (HRMP) and the Underground Test Area (UGTA) Project. These programs are administered by the U.S. Department of Energy, National Nuclear Security Administration, Nevada Site Office (NNSA/NSO) through the Defense Programs and Environmental Restoration Divisions, respectively. HRMP-sponsored work emphasizes the Defense Programs goal of responsible management of natural resources at the NTS, while UGTA-funded work focuses on defining the extent of radionuclide contamination in NTS groundwater resulting from underground nuclear testing. The report is organized on a topical basis, and contains eight chapters that reflect the range of technical work performed by LLNL-ANCD in support of HRMP and UGTA. Chapter 1 describes recent hot well sampling efforts at the NTS, and presents the results of chemical and isotopic analyses of groundwater samples from six near-field wells. These include the Cambric (UE-5n), Bilby (U-3cn PS No.2), Bourbon (UE-7nS), Nash (UE-2ce), Tybo/Benham (ER-20-5 No.3), and Almendro (U-19v PS No.1ds) sites. The data generated by the hot well program is vital to the development and validation of contaminant transport models at the NTS. Chapter 2 discusses the results of xenon isotope measurements of groundwater samples from the six near-field wells described in Chapter 1. This work demonstrates that fission xenon is present in the water at levels that are readily measurable and highlights the significant differences in xenon concentrations and isotopic abundances at different sites. These differences provide insight into the early cooling history of nuclear test cavities, and may assist in predicting the distribution of the source term in the near-field environment. Chapter 3 is an investigation of the distribution

  3. A Technology Based Program That Matches Enrichment Resources With Student Strengths

    Directory of Open Access Journals (Sweden)

    J.S. Renzulli

    2007-09-01

    Full Text Available Remarkable advances in instructionalcommunication technology (ICT have now made ispossible to provide high levels of enrichment and thekinds of curricular differentiation that facilitateadvanced learning services to students who have accessto a computer and the Internet. But in order tomaximize the potential if ICT it is necessary to constructprograms that are based on learning theory that goesbeyond the didactic and prescriptive models that haveresulted in too much worksheets-on-line and electronicencyclopedias. The Renzulli Learning System (RLSuses a strength-based learning theory called theEnrichment Triad Model that is purposefully designedto promote advanced level learning, creativeproductivity, and high levels of student engagement byfocusing on the application of knowledge rather than themere acquisition and storage of information.The Renzulli Learning System is acomprehensive program that begins by providing acomputer-generated profile of each student’s academicstrengths, interests, learning styles, and preferred modesof expression. A search engine then matches Internetresources to the student’s profile from fourteen carefullyscreened data bases that are categorized by subject area,grade level, state curricular standards, and degree ofcomplexity. There are also hundreds of enrichmentactivities that can be down loaded and reproduced forindividual or group learning activities. A managementsystem called the Wizard Project Maker guides studentsin the application of knowledge to teacher or studentselected assignments, independent research studies, orcreative projects that individuals or small groups wouldlike to pursue. Students and teachers can evaluate thequality of students’ products using a rubric called TheStudent Product Assessment Form. Students can rateeach site visited, conduct a self-assessment of what theyhave gained from the site, and place resources in theirown Total talent Portfolio for future use. RLS alsoincludes a

  4. Solar Radiation Resource Assessment Project. Program overview of fiscal year 1993

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    The mission of the Solar Radiation Resource Assessment Project is to provide essential information about the solar radiation resource to users and planners of solar technologies so that they can make informed and timely decisions concerning applications of those technologies. The project team accomplishes this by producing and disseminating relevant and reliable information about solar radiation. Topics include: Variability of solar radiation, measurements of solar radiation, spectral distribution of solar radiation, and assessment of the solar resource. FY 1993 accomplishments are detailed.

  5. Development of a comprehensive and sustainable gynecologic oncology training program in western Kenya, a low resource setting.

    Science.gov (United States)

    Rosen, Barry; Itsura, Peter; Tonui, Philip; Covens, Alan; van Lonkhuijzen, Luc; Orang'o, Elkanah Omenge

    2017-08-01

    To provide information on the development of a gynecologic oncology training program in a low-resource setting in Kenya. This is a review of a collaboration between Kenyan and North American physicians who worked together to develop a gynecologic oncology training in Kenya. We review the published data on the increase of cancer incidence in sub-Saharan Africa and outline the steps that were taken to develop this program. The incidence of cervical cancer in Kenya is very high and is the leading cause of cancer mortality in Kenya. WHO identifies cancer as a new epidemic affecting countries in sub-Saharan Africa. In Kenya, a country of 45 million, there is limited resources to diagnose and treat cancer. In 2009 in western Kenya, at Moi University there was no strategy to manage oncology in the Reproductive Health department. There was only 1 gynecologic oncologists in Kenya in 2009. A collaboration between Canadian and Kenya physicians resulted in development of a gynecologic oncology clinical program and initiation of fellowship training in Kenya. In the past 4 years, five fellows have graduated from a 2 year fellowship training program. Integration of data collection on all the patients as part of this program provided opportunities to do clinical research and to acquire peer reviewed grants. This is the first recognized fellowship training program in sub-Saharan Africa outside of South Africa. It is an example of a collaborative effort to improve women's health in a low-resource country. This is a Kenyan managed program through Moi University. These subspecialty trained doctors will also provide advice that will shape health care policy and provide sustainable expertise for women diagnosed with a gynecologic cancer.

  6. An Interval-Parameter Fuzzy Linear Programming with Stochastic Vertices Model for Water Resources Management under Uncertainty

    Directory of Open Access Journals (Sweden)

    Yan Han

    2013-01-01

    Full Text Available An interval-parameter fuzzy linear programming with stochastic vertices (IFLPSV method is developed for water resources management under uncertainty by coupling interval-parameter fuzzy linear programming (IFLP with stochastic programming (SP. As an extension of existing interval parameter fuzzy linear programming, the developed IFLPSV approach has advantages in dealing with dual uncertainty optimization problems, which uncertainty presents as interval parameter with stochastic vertices in both of the objective functions and constraints. The developed IFLPSV method improves upon the IFLP method by allowing dual uncertainty parameters to be incorporated into the optimization processes. A hybrid intelligent algorithm based on genetic algorithm and artificial neural network is used to solve the developed model. The developed method is then applied to water resources allocation in Beijing city of China in 2020, where water resources shortage is a challenging issue. The results indicate that reasonable solutions have been obtained, which are helpful and useful for decision makers. Although the amount of water supply from Guanting and Miyun reservoirs is declining with rainfall reduction, water supply from the South-to-North Water Transfer project will have important impact on water supply structure of Beijing city, particularly in dry year and extraordinary dry year.

  7. MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway.

    Science.gov (United States)

    Kuwabara, Yasuhide; Horie, Takahiro; Baba, Osamu; Watanabe, Shin; Nishiga, Masataka; Usami, Shunsuke; Izuhara, Masayasu; Nakao, Tetsushi; Nishino, Tomohiro; Otsu, Kinya; Kita, Toru; Kimura, Takeshi; Ono, Koh

    2015-01-16

    In some patients with type 2 diabetes mellitus (DM) without hypertension, cardiac hypertrophy and attenuated cardiac function are observed, and this insult is termed diabetic cardiomyopathy. To date, microRNA (miRNAs or miR) functions in diabetic cardiomyopathy remain to be elucidated. To clarify the functions of miRNAs involved in diabetic cardiomyopathy caused by type 2 DM. C57BL/6 mice were fed a high-fat diet (HFD) for 20 weeks, which induced obesity and type 2 DM. miRNA microarray analyses and real-time polymerase chain reaction revealed that miR-451 levels were significantly increased in the type 2 DM mouse hearts. Because excess supply of saturated fatty acids is a cause of diabetic cardiomyopathy, we stimulated neonatal rat cardiac myocytes with palmitic acid and confirmed that miR-451 expression was increased in a dose- and time-dependent manner. Loss of miR-451 function ameliorated palmitate-induced lipotoxicity in neonatal rat cardiac myocytes. Calcium-binding protein 39 (Cab39) is a scaffold protein of liver kinase B1 (LKB1), an upstream kinase of AMP-activated protein kinase (AMPK). Cab39 was a direct target of miR-451 in neonatal rat cardiac myocytes and Cab39 overexpression rescued the lipotoxicity. To clarify miR-451 functions in vivo, we generated cardiomyocyte-specific miR-451 knockout mice. HFD-induced cardiac hypertrophy and contractile reserves were ameliorated in cardiomyocyte-specific miR-451 knockout mice compared with control mice. Protein levels of Cab39 and phosphorylated AMPK were increased and phosphorylated mammalian target of rapamycin (mTOR) was reduced in cardiomyocyte-specific miR-451 knockout mouse hearts compared with control mouse hearts. Our results demonstrate that miR-451 is involved in diabetic cardiomyopathy through suppression of the LKB1/AMPK pathway. © 2014 American Heart Association, Inc.

  8. A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway

    Science.gov (United States)

    Xie, Min; Zhang, Dou; Dyck, Jason R. B.; Li, Yi; Zhang, Hui; Morishima, Masae; Mann, Douglas L.; Taffet, George E.; Baldini, Antonio; Khoury, Dirar S.; Schneider, Michael D.

    2006-01-01

    TGF-β-activated kinase-1 (TAK1), also known as MAPKK kinase-7 (MAP3K7), is a candidate effector of multiple circuits in cardiac biology and disease. Here, we show that inhibition of TAK1 in mice by a cardiac-specific dominant-negative mutation evokes electrophysiological and biochemical properties reminiscent of human Wolff–Parkinson–White syndrome, arising from mutations in AMP-activated protein kinase (AMPK), most notably, accelerated atrioventricular conduction and impaired AMPK activation. To test conclusively the biochemical connection from TAK1 to AMPK suggested by this phenotype, we disrupted TAK1 in mouse embryos and embryonic fibroblasts by Cre-mediated recombination. In TAK1-null embryos, the activating phosphorylation of AMPK at T172 was blocked, accompanied by defective AMPK activity. However, loss of endogenous TAK1 causes midgestation lethality, with defective yolk sac and intraembryonic vasculature. To preclude confounding lethal defects, we acutely ablated floxed TAK1 in culture by viral delivery of Cre. In culture, endogenous TAK1 was activated by oligomycin, the antidiabetic drug metformin, 5-aminoimidazole-4-carboxamide riboside (AICAR), and ischemia, well established triggers of AMPK activity. Loss of TAK1 in culture blocked T172 phosphorylation induced by all three agents, interfered with AMPK activation, impaired phosphorylation of the endogenous AMPK substrate acetyl CoA carboxylase, and also interfered with activation of the AMPK kinase LKB1. Thus, by disrupting the endogenous TAK1 locus, we prove a pivotal role for TAK1 in the LKB1/AMPK signaling axis, an essential governor of cell metabolism. PMID:17085580

  9. A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway.

    Science.gov (United States)

    Xie, Min; Zhang, Dou; Dyck, Jason R B; Li, Yi; Zhang, Hui; Morishima, Masae; Mann, Douglas L; Taffet, George E; Baldini, Antonio; Khoury, Dirar S; Schneider, Michael D

    2006-11-14

    TGF-beta-activated kinase-1 (TAK1), also known as MAPKK kinase-7 (MAP3K7), is a candidate effector of multiple circuits in cardiac biology and disease. Here, we show that inhibition of TAK1 in mice by a cardiac-specific dominant-negative mutation evokes electrophysiological and biochemical properties reminiscent of human Wolff-Parkinson-White syndrome, arising from mutations in AMP-activated protein kinase (AMPK), most notably, accelerated atrioventricular conduction and impaired AMPK activation. To test conclusively the biochemical connection from TAK1 to AMPK suggested by this phenotype, we disrupted TAK1 in mouse embryos and embryonic fibroblasts by Cre-mediated recombination. In TAK1-null embryos, the activating phosphorylation of AMPK at T172 was blocked, accompanied by defective AMPK activity. However, loss of endogenous TAK1 causes midgestation lethality, with defective yolk sac and intraembryonic vasculature. To preclude confounding lethal defects, we acutely ablated floxed TAK1 in culture by viral delivery of Cre. In culture, endogenous TAK1 was activated by oligomycin, the antidiabetic drug metformin, 5-aminoimidazole-4-carboxamide riboside (AICAR), and ischemia, well established triggers of AMPK activity. Loss of TAK1 in culture blocked T172 phosphorylation induced by all three agents, interfered with AMPK activation, impaired phosphorylation of the endogenous AMPK substrate acetyl CoA carboxylase, and also interfered with activation of the AMPK kinase LKB1. Thus, by disrupting the endogenous TAK1 locus, we prove a pivotal role for TAK1 in the LKB1/AMPK signaling axis, an essential governor of cell metabolism.

  10. Chalcones suppress fatty acid-induced lipid accumulation through a LKB1/AMPK signaling pathway in HepG2 cells.

    Science.gov (United States)

    Zhang, Tianshun; Yamamoto, Norio; Ashida, Hitoshi

    2014-06-01

    Excessive lipid accumulation in the liver has been proposed to cause hyperlipidemia, diabetes and fatty liver disease. 4-Hydroxyderricin (4HD), xanthoangelol (XAG), cardamonin (CAR) and flavokawain B (FKB) are chalcones that have exhibited various biological effects against obesity, inflammation, and diabetes; however, little is known about the inhibitory effects of these chalcones on fatty liver disease. In the present study, we investigated the ability of 4HD, XAG, CAR, and FKB to reduce lipid accumulation in hepatocytes. When HepG2 cells were treated with a mixture of fatty acids (FAs; palmitic acid : oleic acid = 1 : 2 ratio), significant lipid accumulation was observed. Under the same experimental conditions, addition of chalcones at 5 μM significantly suppressed the FA-induced lipid accumulation. We found that the expression of sterol regulatory element-binding protein-1 (SREBP-1), a key molecule involved in lipogenesis, was decreased in these chalcone-treated cells. We also found that these chalcones increased the expression of peroxisome proliferator-activated receptor α (PPARα), which is involved in FA oxidation. Moreover, these chalcones increased phosphorylation of AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1), upstream regulators of SREBP-1 and PPARα. We confirmed that an AMPK inhibitor, compound C, reversed chalcone-induced changes in SREBP-1 and PPARα expression in the HepG2 cells. Collectively, we found that 4HD, XAG, CAR, and XAG attenuated lipid accumulation through activation of the LKB1/AMPK signaling pathway in HepG2 cells.

  11. The Phil-Lidar 2 Program: National Resource Inventory of the Philippines Using LIDAR and Other Remotely Sensed Data

    Science.gov (United States)

    Blanco, A. C.; Tamondong, A. M.; Perez, A. M. C.; Ang, M. R. C. O.; Paringit, E. C.

    2015-04-01

    The Philippines embarked on a nationwide mapping endeavour through the Disaster Risk and Exposure Assessment for Mitigation (DREAM) Program of the University of the Philippines and the Department of Science and Technology (DOST). The derived accurate digital terrain models (DTMs) are used in flood models to generate risk maps and early warning system. With the availability of LiDAR data sets, the Phil-LiDAR 2 program was conceptualized as complementary to existing programs of various national government agencies and to assist local government units. Phil-LiDAR 2 aims to provide an updated natural resource inventory as detailed as possible using LiDAR point clouds, LiDAR derivative products, orthoimages and other RS data. The program assesses the following natural resources over a period of three years from July 2014: agricultural, forest, coastal, water, and renewable energy. To date, methodologies for extracting features from LiDAR data sets have been developed. The methodologies are based on a combination of object-based image analysis, pixel-based image analysis, optimization of feature selection and parameter values, and field surveys. One of the features of the Phil-LiDAR 2 program is the involvement of fifteen (15) universities throughout the country. Most of these do not have prior experience in remote sensing and mapping. With such, the program has embarked on a massive training and mentoring program. The program is producing more than 200 young RS specialists who are protecting the environment through RS and other geospatial technologies. This paper presents the program, the methodologies so far developed, and the sample outputs.

  12. Infrastructure and Resources of Private Schools in Cali and the Implementation of the Bilingual Colombia Program

    Science.gov (United States)

    Miranda, Norbella; Echeverry, Ángela Patricia

    2010-01-01

    Institutional factors affect the implementation of educational policies. Physical school infrastructure and the availability of resources determine to a certain extent whether a policy may be successfully transformed into practice. This article provides a description and analysis of school infrastructure and resources of private institutions of…

  13. Identifying state resources and support programs on e-government websites for persons with intellectual and developmental disabilities.

    Science.gov (United States)

    Fisher, Kathleen M; Peterson, Justin D; Albert, Jon D

    2015-01-01

    This descriptive cross-sectional study identified resources and programs that are available nationwide on the Internet to support individuals and families with intellectual and developmental disabilities (I/DD), with a focus on intellectual disability. This evaluation included easily identifiable information on specific resources and highlighted unique programs found in individual states that were linked from e-government websites. Researchers documented the ease of access and available information for all 50 states and the District of Columbia. A number of disparities and areas for improvement were recorded for states and I/DD websites. The researchers conclude that a number of additional health and support services will be needed to address the growing needs of this vulnerable population.

  14. The transition to medication adoption in publicly funded substance use disorder treatment programs: organizational structure, culture, and resources.

    Science.gov (United States)

    Knudsen, Hannah K; Roman, Paul M

    2014-05-01

    Medications for the treatment of substance use disorders (SUDs) are not widely available in publicly funded SUD treatment programs. Few studies have drawn on longitudinal data to examine the organizational characteristics associated with programs transitioning from not delivering any pharmacotherapy to adopting at least one SUD medication. Using two waves of panel longitudinal data collected over a 5-year period, we measured the transition to medication adoption in a cohort of 190 publicly funded treatment organizations that offered no SUD medications at baseline. Independent variables included organizational characteristics, medical resources, funding, treatment culture, and detailing activities by pharmaceutical companies. Of 190 programs not offering SUD pharmacotherapy at baseline, 22.6% transitioned to offering at least one SUD medication at follow-up approximately 5 years later. Multivariate logistic regression results indicated that the employment of at least one physician at baseline, having a greater proportion of Medicaid clients, and pharmaceutical detailing were positively associated with medication adoption. Adoption of pharmacotherapy was more likely in programs that had greater medical resources, Medicaid funding, and contact with pharmaceutical companies. Given the potential expansion of Medicaid under the Affordable Care Act, patients served by publicly funded programs may gain greater access to such treatments, but research is needed to document health reform's impact on this sector of the treatment system.

  15. Optima: A Model for HIV Epidemic Analysis, Program Prioritization, and Resource Optimization

    National Research Council Canada - National Science Library

    Kerr, Cliff C; Stuart, Robyn M; Gray, Richard T; Shattock, Andrew J; Fraser-Hurt, Nicole; Benedikt, Clemens; Haacker, Markus; Berdnikov, Maxim; Mahmood, Ahmed Mohamed; Jaber, Seham Abdalla; Gorgens, Marelize; Wilson, David P

    2015-01-01

    Optima is a software package for modeling HIV epidemics and interventions that we developed to address practical policy and program problems encountered by funders, governments, health planners, and program implementers...

  16. Enhanced Geothermal Systems (EGS) R&D Program: US Geothermal Resources Review and Needs Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Entingh, Dan; McLarty, Lynn

    2000-11-30

    The purpose of this report is to lay the groundwork for an emerging process to assess U.S. geothermal resources that might be suitable for development as Enhanced Geothermal Systems (EGS). Interviews of leading geothermists indicate that doing that will be intertwined with updating assessments of U.S. higher-quality hydrothermal resources and reviewing methods for discovering ''hidden'' hydrothermal and EGS resources. The report reviews the history and status of assessment of high-temperature geothermal resources in the United States. Hydrothermal, Enhanced, and Hot Dry Rock resources are addressed. Geopressured geothermal resources are not. There are three main uses of geothermal resource assessments: (1) They inform industry and other interest parties of reasonable estimates of the amounts and likely locations of known and prospective geothermal resources. This provides a basis for private-sector decisions whether or not to enter the geothermal energy business at all, and for where to look for useful resources. (2) They inform government agencies (Federal, State, local) of the same kinds of information. This can inform strategic decisions, such as whether to continue to invest in creating and stimulating a geothermal industry--e.g., through research or financial incentives. And it informs certain agencies, e.g., Department of Interior, about what kinds of tactical operations might be required to support such activities as exploration and leasing. (3) They help the experts who are performing the assessment(s) to clarify their procedures and data, and in turn, provide the other two kinds of users with a more accurate interpretation of what the resulting estimates mean. The process of conducting this assessment brings a spotlight to bear on what has been accomplished in the domain of detecting and understanding reservoirs, in the period since the last major assessment was conducted.

  17. Huntington II Simulation Program - PH. Student Workbook, Teacher's Guide, and Resource Handbook.

    Science.gov (United States)

    Friedland, James

    Described is the computer simulation program "PH." The program consists of three different laboratory investigations dealing with the pH specificity of enzymes. The purpose of the program is to enable tenth- to twelfth-grade students to determine a possible explanation for pH specificity in an experimental, but mathematical, fashion.…

  18. After-School Programs: A Resource for Young Black Males and Other Urban Youth

    Science.gov (United States)

    Woodland, Malcolm H.

    2016-01-01

    While after-school programs are plentiful, they are often developed arbitrarily with little attention given to theoretical underpinnings that may inform program interventions. In this article, after-school programs are situated in resilience theory as protective factors, which encourage resilience among young Black males and other urban youth. The…

  19. Image data processing system requirements study. Volume 1: Analysis. [for Earth Resources Survey Program

    Science.gov (United States)

    Honikman, T.; Mcmahon, E.; Miller, E.; Pietrzak, L.; Yorsz, W.

    1973-01-01

    Digital image processing, image recorders, high-density digital data recorders, and data system element processing for use in an Earth Resources Survey image data processing system are studied. Loading to various ERS systems is also estimated by simulation.

  20. 77 FR 37060 - Critical Infrastructure and Key Resources (CIKR) Asset Protection Technical Assistance Program...

    Science.gov (United States)

    2012-06-20

    ... information provided. SUPPLEMENTARY INFORMATION: The Critical Infrastructure and Key Resources (CIKR) Asset..., Office of Infrastructure Protection, Infrastructure Information Collection Division. Title: Critical...] [FR Doc No: 2012-15014] DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2012-0002] Critical...

  1. 78 FR 26684 - Notice of Funding Availability for the Small Business Transportation Resource Center Program

    Science.gov (United States)

    2013-05-07

    ... Program (BEP) information, SBTRC brochures and literature, Procurement Forecasts; Contracting with DOT... authorities for the SBTRC's headquarters state must have representation on the planning committee. This...

  2. 78 FR 70617 - Notice of Funding Availability for the Small Business Transportation Resource Center Program

    Science.gov (United States)

    2013-11-26

    ... (STLP) Information, Bonding Education Program (BEP) information, SBTRC brochures and literature... representation on the planning committee. This committee shall be established no later than 60 days after the...

  3. 78 FR 13143 - Notice of Funding Availability for the Small Business Transportation Resource Center Program

    Science.gov (United States)

    2013-02-26

    ... Education Program (BEP) information, SBTRC brochures and literature, Procurement Forecasts; Contracting with... for the SBTRC's headquarters state must have representation on the planning committee. This committee...

  4. Two chalcones, 4-hydroxyderricin and xanthoangelol, stimulate GLUT4-dependent glucose uptake through the LKB1/AMP-activated protein kinase signaling pathway in 3T3-L1 adipocytes.

    Science.gov (United States)

    Ohta, Mitsuhiro; Fujinami, Aya; Kobayashi, Norihiro; Amano, Akiko; Ishigami, Akihito; Tokuda, Harukuni; Suzuki, Nobutaka; Ito, Fumitake; Mori, Taisuke; Sawada, Morio; Iwasa, Koichi; Kitawaki, Jo; Ohnishi, Katsunori; Tsujikawa, Muneo; Obayashi, Hiroshi

    2015-07-01

    4-Hydroxyderricin (4HD) and xanthoangelol (XAG) are major components of n-hexane/ethyl acetate (5:1) extract of the yellow-colored stem juice of Angelica keiskei. 4-Hydroxyderricin and XAG have been reported to increase glucose transporter 4 (GLUT4)-dependent glucose uptake in 3T3-L1 adipocytes, but the detailed mechanism of this phenomenon remains unknown. This present study was aimed at clarifying the detailed mechanism by which 4HD and XAG increase GLUT4-dependent glucose uptake in 3T3-L1 adipocytes. Both 4HD and XAG increased glucose uptake and GLUT4 translocation to the plasma membrane. 4-Hydroxyderricin and XAG also stimulated the phosphorylation of 5' adenosine monophosphate-activated protein kinase (AMPK) and its downstream target acetyl-CoA carboxylase. In addition, phosphorylation of liver kinase B1 (LKB1), which acts upstream of AMPK, was also increased by 4HD and XAG treatment. Small interfering RNA knockdown of LKB1 attenuated 4HD- and XAG-stimulated AMPK phosphorylation and suppressed glucose uptake. These findings demonstrate that 4HD and XAG can increase GLUT4-dependent glucose uptake through the LKB1/AMPK signaling pathway in 3T3-L1 adipocytes. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Implementation of the natural resource damage assessment rule. Workshop summary; interim notification policy: Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-01

    Regulations have been promulgated by the Department of Interior (DOI) which provide an administrative process whereby natural resource trustees may establish the type and extent of injury and evaluate the damages to natural resources. These regulations provide an optional mechanism for Natural Resource Damage Assessments (NRDAs), with four major components. A workshop was held to develop recommendations for DOE-OR regarding implementation of the DOI NRDA regulations at the Oak Ridge Reservation (ORR). The attendants were divided into three working groups to consider (1) administrative/legal requirements, (2) ecological assessments, and (3) the NRDA/economic evaluation process. This report supplies an overview of the DOI NRDA regulations as well as summaries of the consensus of each of the three working groups.

  6. Training Programs of Transnational Corporations as a Foundation of Formation of Private Educational Resources

    Science.gov (United States)

    Tarakanov, Vasily; Kalinina, Alla; Kryukova, Ekaterina

    2017-01-01

    Purpose: The purpose of this paper is to analyze training programs for transnational corporations, educational services market, and society. Design/methodology/approach: The paper consists of three components: determination of the role and meaning of training programs of transnational corporations in the system of formation of private educational…

  7. Resource List--Using Evidence-Based Programs as the Foundation of Comprehensive Sex Education

    Science.gov (United States)

    Advocates for Youth, 2015

    2015-01-01

    Decades of research have identified dozens of programs that are effective in helping young people reduce their risk for pregnancy, HIV, and STDs. These evidence-based programs utilize strategies that include the provision of accurate, honest information about abstinence as well as contraception and can serve as the foundation for comprehensive sex…

  8. Multidisciplinary research program directed toward utilization of solar energy through bioconversion of renewable resources

    Energy Technology Data Exchange (ETDEWEB)

    1980-07-01

    Progress is reported in this multidisciplinary research program. Genetic selection of superior trees, physiological basis of vigor, tissue culture systems leading to cloning of diploid and haploid cell lines are discussed in the Program A report. The physiological basis of enhanced oleoresin formation in southern pines when treated with sublethal concentrations of the herbicide paraquat was investigated in Program B. In Program C, metabolic changes in the stems of slash pine, in vivo, after application with paraquat were determined. The use of phdoem and xylem tissue slices as a laboratory model for studying paraquat associated- and normal-terpene synthesis in pines is discussed. The biochemistry and physiology of methane formation from cellulose during anaerobic fermentation are discussed in the Program D report. (DMC)

  9. An inexact two-stage stochastic programming model for water resources management in Nansihu Lake Basin, China.

    Science.gov (United States)

    Xie, Y L; Huang, G H; Li, W; Li, J B; Li, Y F

    2013-09-30

    In this study, an inexact two-stage water resources management model was developed for multi-regional water resources planning in the Nansihu lake Basin, China. Four planning districts, four water users, and five water sources were considered in the optimization model, with net system benefit, recourse cost, water supply cost, and wastewater treatment cost being analyzed. Methods of interval-parameter programming (IPP) and two-stage stochastic programming (TSP) were incorporated into the model to tackle uncertainties described by both interval values and probability distributions. A number of scenarios corresponding to different river inflow levels were examined, and the results indicated that different inflow levels could lead to different water allocation schemes with varied system benefit and system-failure risk. In general, the developed model can provide an effective linkage between economic benefits and the associated penalties attributed to the violation of predefined policies. The modeling results were valuable for supporting the adjustment or justification of the existing water allocation schemes within a complicated water resources system under uncertainty. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Motives and Tensions in the Release of Open Educational Resources: The UKOER Program

    Science.gov (United States)

    Falconer, Isobel; Littlejohn, Allison; McGill, Lou; Beetham, Helen

    2016-01-01

    Open educational resources (OER) have been promoted as a path to universal education, supporting economic development and intercultural dialogue. However, to realise these benefits requires greater understanding of the factors that influence both OER supply and use. This paper examines an aspect of the supply side of the OER lifecycle--the motives…

  11. Analysis of Energy Resources and Programs of the Soviet Union and Eastern Europe. Appendix B. Coal

    Science.gov (United States)

    1973-12-01

    13 to 20 percent), but sulfur contents are high (1.8 to 4.8 percent). 2- Karaganda Basin The Karaganda Basin is also of Carboniferous age. The... Carboniferous (Paleozt.in) to r«.* IKaieozoic) to Cretaceous (Mesozoic) and Tertiary. Table n-51 shows estlmatcl con 1 resources of Hungary

  12. Resources for Hospitalised Children: An Evaluation of the Starbright World Program by Child Life Specialists

    Science.gov (United States)

    Cashin, Catherine S.; Witt, Susan D.

    2010-01-01

    Children who are hospitalised need as many normalising experiences as possible. Child life specialists work to try to normalise the patient's hospital stay by providing resources that are developmentally appropriate and that allow children to be themselves, considering the parameters of the child's medical status. This article examines the use of…

  13. An integer programming model to optimize resource allocation for wildfire containment.

    Science.gov (United States)

    Geoffrey H. Donovan; Douglas B. Rideout

    2003-01-01

    Determining the specific mix of fire-fighting resources for a given fire is a necessary condition for identifying the minimum of the Cost Plus Net Value Change (C+NVC) function. Current wildland fire management models may not reliably do so. The problem of identifying the most efficient wildland fire organization is characterized mathematically using integer-...

  14. Resource list: Clinical care programs for gender-nonconforming children and adolescents.

    Science.gov (United States)

    Hsieh, Sam; Leininger, Jennifer

    2014-06-01

    Locating specialized services for gender-nonconforming children and adolescents can be challenging. The following resource list--organized by U.S. and Canada geographical region--serves to help clinicians access the most up-to-date information on this special population and pass it along to their patients and families. Copyright 2014, SLACK Incorporated.

  15. Suggested Resource List. Wisconsin Nutrition Education and Training Program. 4th Revised Edition.

    Science.gov (United States)

    Wisconsin State Dept. of Public Instruction, Madison.

    This resource list on nutrition is divided into 16 subject matter categories. References within each category include information on intended audience, type of media, title, date, author, publisher, price, and annotations. Subjects covered are: (1) athletics/physical fitness; (2) careers; (3) consumerism; (4) dental health; (5) diet/health and…

  16. Support for Resource Constrained Microcontroller Programming by a Broad Developer Community

    Science.gov (United States)

    Amar, Amichi

    2010-01-01

    Resource constrained microcontrollers with as little as several hundred bytes of RAM and a few dozen megahertz of processing power are the most prevalent computing devices on earth. Microcontrollers and the many application components that interface to them, such as sensors, actuators, transceivers and displays are now cheap and readily available.…

  17. Tools for Using Citizen Science in Environmental, Agricultural, and Natural Resources Extension Programs

    Science.gov (United States)

    Stofer, Kathryn A.

    2017-01-01

    Citizen science is quickly becoming a valuable tool in the Extension professional's tool kit. This is the case whether you are a 4-H agent looking to involve youth in agriscience and agriculture-related science, technology, engineering, and math experiential learning activities or an agriculture and natural resources agent seeking to help…

  18. Recruiting Women for Traditionally "Male" Careers: Programs and Resources for Getting Women into the Men's World.

    Science.gov (United States)

    Association of American Colleges, Washington, DC. Project on the Status and Education of Women.

    Since counselors and teachers have found that special materials are often needed to help counter sex role stereotyping and to help young women make more realistic career decisions, this paper lists various resources which have been developed and used by colleges and universities in counseling and recruiting women for careers formerly considered…

  19. Partnering to develop a continuing professional development program in a low-resource setting: Cambodia.

    Science.gov (United States)

    Mack, Heather G; Meng, Ngy; Parsons, Tanya; Schlenther, Gerhard; Murray, Neil; Hart, Richard

    2017-08-01

    To design and implement a continuing professional development (CPD) program for Cambodian ophthalmologists. Partnering (twinning) between the Royal Australian and New Zealand College of Ophthalmologists (RANZCO) and the Cambodian Ophthalmological Society (COS). Practicing ophthalmologists in Cambodia. A conjoint committee comprising 4 ophthalmologists from RANZCO and 3 ophthalmologists from COS was established, supported by a RANZCO administrative team experienced in CPD administration. CPD requirements and recording were adapted from the RANZCO CPD framework. Cambodian ophthalmologists were surveyed during program implementation and after handover to COS. At the end of the 3-year program at handover to COS, a CPD program and online recording system was established. All 47 (100%) practicing ophthalmologists in Cambodia were registered for CPD, and 21/47 (45%) were actively participating in the COS CPD program online recording. Surveys of attitudes toward CPD demonstrated no significant change. Partnering was moderately effective in establishing a CPD program for Cambodian ophthalmologists. Uptake of CPD may have been limited by lack of a requirement for CPD for continuing medical licensure in Cambodia. Follow-up will be necessary to demonstrate CPD program longevity. Copyright © 2017 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

  20. Celebrating minority professionals in forestry and natural resources conservation: proceedings of the symposium on the tenth anniversary of the 2 + 2 joint degree program in forestry and natural resources conservation

    Science.gov (United States)

    Oghenekome U. Onokpise; Don L. Rockwood; Dreamal H. Worthen; Ted Willis

    2008-01-01

    The 22 papers in this symposium highlight the program and its contribution to increasing minority professionals in forestry and natural resources conservation. The tenth anniversary symposium brought together graduates of the program, current students and officials from the universities, the U.S. Forest Service, other agencies, and private industry. The theme of the...

  1. 78 FR 41817 - Notice of Funding Availability for the Small Business Transportation Resource Center Program

    Science.gov (United States)

    2013-07-11

    ... Education Program (BEP) information, SBTRC brochures and literature, Procurement Forecasts; Contracting with... representation on the planning committee. This committee shall be established no later than 60 days after the...

  2. 77 FR 36034 - Notice of Funding Availability for the Small Business Transportation Resource Center Program

    Science.gov (United States)

    2012-06-15

    ... (STLP) Information, Bonding Education Program (BEP) information, SBTRC brochures and literature, Procurement Forecasts; Contracting with DOT booklets, Women and Girls Entrepreneurial Training and Technical... authorities for the SBTRC's headquarters state must have representation on the planning committee. This...

  3. 77 FR 42790 - Notice of Funding Availability for the Small Business Transportation Resource Center Program

    Science.gov (United States)

    2012-07-20

    ... (STLP) Information, Bonding Education Program (BEP) information, SBTRC brochures and literature, Procurement Forecasts; Contracting with DOT booklets, Women and Girls Entrepreneurial Training and Technical... must have representation on the planning committee. This committee shall be established no later than...

  4. 78 FR 4973 - Notice of Funding Availability for the Small Business Transportation Resource Center Program

    Science.gov (United States)

    2013-01-23

    ... Program (BEP) information, SBTRC brochures and literature, Procurement Forecasts; Contracting with DOT booklets, Women and Girls in Transportation Initiative (WITI) information, and any other materials or... for the SBTRC's headquarters state must have representation on the planning committee. This committee...

  5. 78 FR 52827 - Food Distribution Program on Indian Reservations: Income Deductions and Resource Eligibility

    Science.gov (United States)

    2013-08-27

    ... received 98 written comments from seven elected Tribal leaders, seven FDPIR program administrators, three... race, color, national origin, sex, age, political beliefs, religious creed, or disability. The... teleconferences, for collaborative conversations with Tribal leaders and their representatives concerning ways to...

  6. 75 FR 3517 - Notice of Funding Availability for the Small Business Transportation Resource Center Program

    Science.gov (United States)

    2010-01-21

    ... assistance, business training programs, such as, business assessment, management training, counseling..., rehabilitation, restructuring, improvement, or revitalization of any of the nation's modes of transportation...; develop support mechanisms, including management and technical services, that will enable small...

  7. The Search for Quality in the Face of Retrenchment: Planning for Program Consolidation within Resource Capacities.

    Science.gov (United States)

    Mason, Thomas R.

    1985-01-01

    The recent literature on issues of quality, retrenchment, and evaluation suggest the kinds of planning and institutional research needed to aid college and university decision processes to sustain and improve program quality. An extensive bibliography is provided. (MLW)

  8. Multidisciplinary research program directed toward utilization of solar energy through bioconversion of renewable resources. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Finnerty, W. R.

    1976-07-01

    Progress is reported in four research areas of solar bioconversion. The first program deals with the genetic selection of superior trees, physiological basis of vigor, tissue culture, haploid cell lines, and somatic hybridization. The second deals with the physiology of paraquat-induced oleoresin biogenesis. Separate abstracts were prepared for the other two program areas: biochemical basis of paraquat-induced oleoresin production in pines and biochemistry of methanogenesis. (JSR)

  9. Advocacy resource: engaging the media and promoting your cancer program in Africa.

    Science.gov (United States)

    Reams, R Renee; Odedina, Folakemi T; Pressey, Shannon

    2013-07-15

    To address the need for a significant increase in cancer advocacy programs in Africa, the University of Florida (UF), the Prostate Net, and the African Organization for Research and Training in Cancer (AORTIC) co-hosted the first biennial International Workshop on Cancer Advocacy for African Countries (CAAC) on November 29, 2011, one-day prior to AORTIC's 8th International Cancer Conference in Cairo, Egypt. Over 70 African cancer advocates representing about 12 African countries participated in this workshop.The primary goal of the one-day workshop was to inform, educate and empower African cancer advocates to increase the promotion of their cancer programs. The first half of the workshop consisted of five formal PowerPoint presentations focused on the following topics: (a) Understanding Your Community and Assessing your Community Health Assets and Needs; (b) Developing a successful advocacy model for your cancer program; (c) Developing a Relationship with your Elected Officials to Advocate Cancer-related Policies; (d) Engaging the Media and promoting your cancer program; and (e) Developing advocacy plans for sustainability. In this article we summarize the informational content given in the PowerPoint presentation entitled "Engaging the Media and promoting your cancer program". The content given in this article is useful as a how-to guide for both the beginner and the experienced cancer advocate who wants to establish/promote a cancer awareness program.

  10. State-coupled low temperature geothermal resource assessment program, fiscal year 1982. Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Icerman, Larry

    1983-08-01

    This report summarizes the results of low-temperature geothermal energy resource assessment efforts in New Mexico during the period from June 15, 1981 through September 30, 1983, under the sponsorship of the US Department of Energy (Contract DE-AS07-78ID01717). The report is divided into four chapters which correspond to the tasks delineated in the contract. Chapter 5 is a brief summary of the tasks performed under this contract during the period October 1, 1978, through June 30, 1983. This work extends the knowledge of low-temperature geothermal reservoirs with the potential for direct heating applications in New Mexico. The research effort focused on compiling basic geothermal data throughout selected areas in New Mexico in a format suitable for direct transfer to the US Geological Survey for inclusion in the GEOTHERM data file and to the National Oceanic and Atmospheric Administration for use with New Mexico geothermal resources maps.

  11. miRMaid: a unified programming interface for microRNA data resources

    DEFF Research Database (Denmark)

    Jacobsen, Anders; Krogh, Anders; Kauppinen, Sakari

    2010-01-01

    application. The software framework is freely available under the LGPL open source license for academic and commercial use. CONCLUSION: miRMaid is an intuitive and modular software platform designed to unify miRBase and independent miRNA data resources. It enables miRNA researchers to computationally address......ABSTRACT: BACKGROUND: MicroRNAs (miRNAs) are endogenous small RNAs that play a key role in post-transcriptional regulation of gene expression in animals and plants. The number of known miRNAs has increased rapidly over the years. The current release (version 14.0) of miRBase, the central online...... repository for miRNA annotation, comprises over 10.000 miRNA precursors from 115 different species. Furthermore, a large number of decentralized online resources are now available, each contributing with important miRNA annotation and information. RESULTS: We have developed a software framework, designated...

  12. A taxonomy for community-based care programs focused on HIV/AIDS prevention, treatment, and care in resource-poor settings

    Directory of Open Access Journals (Sweden)

    Beth Rachlis

    2013-04-01

    Full Text Available Community-based care (CBC can increase access to key services for people affected by HIV/AIDS through the mobilization of community interests and resources and their integration with formal health structures. Yet, the lack of a systematic framework for analysis of CBC focused on HIV/AIDS impedes our ability to understand and study CBC programs. We sought to develop taxonomy of CBC programs focused on HIV/AIDS in resource-limited settings in an effort to understand their key characteristics, uncover any gaps in programming, and highlight the potential roles they play. Our review aimed to systematically identify key CBC programs focused on HIV/AIDS in resource-limited settings. We used both bibliographic database searches (Medline, CINAHL, and EMBASE for peer-reviewed literature and internet-based searches for gray literature. Our search terms were ‘HIV’ or ‘AIDS’ and ‘community-based care’ or ‘CBC’. Two co-authors developed a descriptive taxonomy through an iterative, inductive process using the retrieved program information. We identified 21 CBC programs useful for developing taxonomy. Extensive variation was observed within each of the nine categories identified: region, vision, characteristics of target populations, program scope, program operations, funding models, human resources, sustainability, and monitoring and evaluation strategies. While additional research may still be needed to identify the conditions that lead to overall program success, our findings can help to inform our understanding of the various aspects of CBC programs and inform potential logic models for CBC programming in the context of HIV/AIDS in resource-limited settings. Importantly, the findings of the present study can be used to develop sustainable HIV/AIDS-service delivery programs in regions with health resource shortages.

  13. Caribbean Equal Access Program: HIV/AIDS Information Resources from the National Library of Medicine

    Energy Technology Data Exchange (ETDEWEB)

    Nancy Dancy, NLM, and Wilma Templin-Branner, ORISE

    2009-01-01

    As the treatment and management of HIV/AIDS continues to evolve with new scientific breakthroughs, treatment discoveries, and management challenges, it is difficult for people living with HIV/AIDS and those who care for them to keep up with the latest information on HIV/AIDS prevention, treatment, and research. The National Library of Medicine, of the National Institutes of Health, has a wealth of health information resources freely available on the Internet to address these needs.

  14. HELP: Handheld Emergency Logistics Program for Generating Structured Requests for Resources in Stressful Conditions

    Science.gov (United States)

    2014-09-01

    to assist with cardiopulmonary resuscitation . (7) “Other” Checkbox. This checkbox should be checked to indicate that the patient needs some other...why there is a need for this type of system. Chapter II discusses the background of digital resource request formats as well as an in-depth history ...complications of the injury, serious illness, or permanent disability. Urgent Surgical–the patient requires forward resuscitative care for life and limb

  15. Evaluation of 4 weeks' neonatal antiretroviral prophylaxis as a component of a prevention of mother-to-child transmission program in a resource-rich setting.

    LENUS (Irish Health Repository)

    Ferguson, Wendy

    2011-05-01

    In resource-rich settings, universal adoption of a 4- rather than 6-week neonatal antiretroviral (ARV) prophylaxis regimen could reduce toxicity and results in cost savings, provided prevention of mother-to-child transmission program effectiveness is not compromised.

  16. Strategic Program for Biodiversity and Water Resource Management and Climate Change Adaptation in Pakistan

    Science.gov (United States)

    Sher, Hassan; Aldosari, Ali

    2014-05-01

    Population pressure, climate change and resulting extreme weather scenarios, armed con?ict and economic pressure have put the situation of Pakistan's biodiversity at risk. Melting glaciers, deforestation, erosion, landslides and depletion of agricultural areas are aggravating the regulation of water ?ow in Pakistan. In Pakistan agro-biodiversity is central to human survival and play vital role in the economy of the country. It contributes 21% to the GDP, employs 45% of the labor force and contributes 71% of the export earnings. Agro- biodiversity in Pakistan is greatly affected by short term climate variability and could be harmed signi?cantly by long-term climate change. As the duration of crop growth cycle is related to temperature, an increase in temperature will speed up crop growth and shorten the duration between sowing and harvesting. This shortening could have an adverse effect on productivity of crops. The present assessment also revealed that hydrological cycle is also likely to be in?uenced by global warming. Since the agricultural crops are heavily dependent on the water, and water resources are inextricably linked with climate; therefore, the projected climate change has serious implications for water resources of the country. The freshwater resources, in Pakistan, are based on snow- and glacier-melt and monsoon rains, both being highly sensitive to climate change. The country speci?c current information strongly suggests that: decrease in glacier volume and snow cover leading to alterations in the seasonal ?ow pattern of Indus River System; increased annual ?ows for a few decades followed by decline in ?ows in subsequent years; increase in the formation and burst of glacial lakes; higher frequency and intensity of extreme climate events coupled with irregular monsoon rains causing frequent ?oods and droughts; and greater demand of water due to higher evapotranspiration rates at elevated temperatures. These trends will have large impact on the spatial

  17. Optimising the extraction rate of a non-durable non-renewable resource in a monopolistic market: a mathematical programming approach.

    Science.gov (United States)

    Corominas, Albert; Fossas, Enric

    2015-01-01

    We assume a monopolistic market for a non-durable non-renewable resource such as crude oil, phosphates or fossil water. Stating the problem of obtaining optimal policies on extraction and pricing of the resource as a non-linear program allows general conclusions to be drawn under diverse assumptions about the demand curve, discount rates and length of the planning horizon. We compare the results with some common beliefs about the pace of exhaustion of this kind of resources.

  18. Yucca Mountain Biological Resources Monitoring Program; Progress report, October 1992--December 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-05-01

    The US Department of Energy (DOE) is required by the Nuclear Waste Policy Act of (as amended in 1987) to study and characterize the suitability of Yucca Mountain as a potential geologic repository for high-level nuclear waste. During site characterization, the DOE will conduct a variety of geotechnical, geochemical, geological, and hydrological studies to determine the suitability of Yucca Mountain as a potential repository. To ensure that site characterization activities do not adversely affect the environment at Yucca Mountain, a program has been implemented to monitor and mitigate potential impacts and ensure activities comply with applicable environmental regulations. This report describes the activities and accomplishments of EG&G Energy Measurements, Inc. (EG&G/EM) from October 1992 through December 1993 for six program areas within the Terrestrial Ecosystem component of the environmental program for the Yucca Mountain Site Characterization Project (YMP): Site Characterization Effects, Desert Tortoises (Gopherus agassizii), Habitat Reclamation, Monitoring and Mitigation, Radiological Monitoring, and Biological Support.

  19. On the Cutting Edge Professional Development Program: Workshop and Web Resources for Current and Future Geoscience Faculty

    Science.gov (United States)

    MacDonald, R.; Manduca, C. A.; Mogk, D. W.; Tewksbury, B. J.

    2004-12-01

    Recognizing that many college and university faculty receive little formal training in teaching, are largely unaware of advances in research on teaching and learning, and face a variety of challenges in advancing in academic careers, the National Science Foundation-funded program On the Cutting Edge provides professional development for current and future faculty in the geosciences at various stages in their careers. The program includes a series of six multi-day workshops, sessions and one-day workshops at professional meetings, and a website with information about workshop opportunities and a variety of resources that bring workshop content to faculty (http://serc.carleton.edu/NAGTWorkshops). The program helps faculty improve their teaching and their job satisfaction by providing resources on instructional methods, geoscience content, and strategies for career planning. Workshop and website resources address innovative and effective practices in teaching, course design, delivery of instructional materials, and career planning, as well as approaches for teaching particular topics and strategies for starting and maintaining a research program in various institutional settings. Each year, special workshops for graduate students and post-doctoral fellows interested in academic careers and for early career faculty complement offerings on course design and emerging topics that are open to the full geoscience community. These special workshops include sessions on topics such as dual careers, gender issues, family-work balance, interviewing and negotiating strategies. The workshops serve as opportunities for networking and community building, with participants building connections with other participants as well as workshop leaders. Workshop participants reflect the full range of institutional diversity as well as ethnic and racial diversity beyond that of the geoscience faculty workforce. More than 40 percent of the faculty participants are female. Of the faculty

  20. Evaluation of an educational program for essential newborn care in resource-limited settings: Essential Care for Every Baby.

    Science.gov (United States)

    Thukral, Anu; Lockyer, Jocelyn; Bucher, Sherri L; Berkelhamer, Sara; Bose, Carl; Deorari, Ashok; Esamai, Fabian; Faremo, Sonia; Keenan, William J; McMillan, Douglas; Niermeyer, Susan; Singhal, Nalini

    2015-06-24

    Essential Care for Every Baby (ECEB) is an evidence-based educational program designed to increase cognitive knowledge and develop skills of health care professionals in essential newborn care in low-resource areas. The course focuses on the immediate care of the newborn after birth and during the first day or until discharge from the health facility. This study assessed the overall design of the course; the ability of facilitators to teach the course; and the knowledge and skills acquired by the learners. Testing occurred at 2 global sites. Data from a facilitator evaluation survey, a learner satisfaction survey, a multiple choice question (MCQ) examination, performance on two objective structured clinical evaluations (OSCE), and pre- and post-course confidence assessments were analyzed using descriptive statistics. Pre-post course differences were examined. Comments on the evaluation form and post-course group discussions were analyzed to identify potential program improvements. Using ECEB course material, master trainers taught 12 facilitators in India and 11 in Kenya who subsequently taught 62 providers of newborn care in India and 64 in Kenya. Facilitators and learners were satisfied with their ability to teach and learn from the program. Confidence (3.5 to 5) and MCQ scores (India: pre 19.4, post 24.8; Kenya: pre 20.8, post 25.0) improved (p improvement. These included additional time for hands-on practice, including practice in a clinical setting, the addition of video learning aids and the adaptation of content to conform to locally recommended practices. ECEB program was highly acceptable, demonstrated improved confidence, improved knowledge and developed skills. ECEB may improve newborn care in low resource settings if it is part of an overall implementation plan that addresses local needs and serves to further strengthen health systems.

  1. A Practitioner's Guide: Strategies, Programs, and Resources for Youth Employability Development. Revised Edition.

    Science.gov (United States)

    Smith, Thomas J.; And Others

    This guide to youth unemployment problems is based on the belief that a comprehensive system of program initiatives offers the best solutions. The principal focus is on vocationally at-risk youth. The first chapter defines and describes the target group, and outlines needs and appropriate responses. The second section describes the following eight…

  2. 76 FR 30990 - Notice of Funding Availability for the Small Business Transportation Resource Center Program

    Science.gov (United States)

    2011-05-27

    ..., SBTRC brochures and literature, Procurement Forecasts; Contracting with DOT booklets, and any other... representation on the planning committee. This committee shall be established no later than 60 days after the..., facilities and equipment to perform the services described in this announcement. (H) Women & Girls Program 1...

  3. 78 FR 13148 - Notice of Funding Availability for the Small Business Transportation Resource Center Program

    Science.gov (United States)

    2013-02-26

    ... Program (BEP) information, SBTRC ] brochures and literature, Procurement Forecasts; Contracting with DOT booklets, Women and Girls in Transportation Initiative (WITI) information, and any other materials or... headquarters state must have representation on the planning committee. This committee shall be established no...

  4. Deaf/Blind. Resource Manuals for Program for Exceptional Children. Volume X.

    Science.gov (United States)

    Georgia State Dept. of Education, Atlanta. Office of Instructional Services.

    The manual is intended to help local education agencies implement Georgia's laws for providing effective instructional programs for deaf-blind children. A definition and eligibility criteria for deaf-blind children are presented. A section discussing due process considers screening, referral, comprehensive evaluation, individualized education…

  5. Sharing Programming Resources Between Bio* Projects Through Remote Procedure Call and Native Call Stack Strategies

    NARCIS (Netherlands)

    Prins, J.C.P.; Goto, N.; Yates, A.; Gautier, L.; Willis, S.; Fields, C.; Katayama, T.

    2012-01-01

    Open-source software (OSS) encourages computer programmers to reuse software components written by others. In evolutionary bioinformatics, OSS comes in a broad range of programming languages, including C/C++, Perl, Python, Ruby, Java, and R. To avoid writing the same functionality multiple times for

  6. Huntington II Simulation Program - RATS. Student Workbook, Teacher's Guide, and Resource Handbook.

    Science.gov (United States)

    Frishman, Austin

    Presented are instructions for the use of "RATS," a model simulating the dynamics of a rat population in either a city or an apartment house. The student controls the conditions of growth and sets the points at which the computer program prints reports. The rat population is controlled by variables including garbage levels selected for the site,…

  7. Information resources for assessing health effects from chemical exposure: Office of pesticides programs

    Energy Technology Data Exchange (ETDEWEB)

    Fenner-Crisp, P. [Environmental Protection Agency, Washington, DC (United States)

    1990-12-31

    The US Environmental Protection Agency (EPA) Office of Pesticide Programs is trying to develop a complete picture of a chemical`s toxicity and exposure profile. It is also important to share information in the office`s files because of pesticides, particularly as a consequence of agricultural use, find their way into places not necessarily intended.

  8. Hydrologic resources management program and underground test area operable unit fy 1997

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D. F., LLNL

    1998-05-01

    This report present the results of FY 1997 technical studies conducted by the Lawrence Livermore National Laboratory (LLNL) as part of the Hydrology and Radionuclide Migration Program (HRMP) and Underground Test Area Operable Unit (UGTA). The HRMP is sponsored by the US Department of Energy to assess the environmental (radiochemical and hydrologic) consequences of underground nuclear weapons testing at the Nevada Test Site.

  9. Agricultural Resources Materials for Agricultural Education Programs. Core Agricultural Education Curriculum, Central Cluster.

    Science.gov (United States)

    Illinois Univ., Urbana. Office of Agricultural Communications and Education.

    This curriculum guide contains four units with relevant problem areas and is intended as a source unit for agricultural education. These problem areas have been selected as suggested areas of study to be included in a core curriculum for secondary students enrolled in an agricultural education program. Each problem area includes some or all of the…

  10. The American Association of Occupational Health Nurses' Respiratory Protection Education Program and Resources Webkit for Occupational Health Professionals.

    Science.gov (United States)

    Pompeii, Lisa; Byrd, Annette; Delclos, George L; Conway, Sadie H

    2016-12-01

    Organizations are required to adhere to the Occupational Safety and Health Administration's (OSHA) Respiratory Protection Standard (29 CFR 1910.134) if they have workers that wear a respirator on the job. They must also have an employee "suitably trained" to administer their program. The National Institute for Occupational Safety and Health and its National Personal Protective Technology Laboratory have worked to champion the occupational health nurse in this role by collaborating with the American Association of Occupational Health Nurses to develop free, online respiratory protection training and resources (RPP Webkit). This article describes the development, content, and success of this training. To date, 724 participants have completed the training, 32.6% of whom lead their organization's respiratory protection program, 15.3% who indicated they will lead a program in the near future, and 52% who did not lead a program, but indicated that the training was relevant to their work. The majority "strongly agreed" the training was applicable to their work and it enhanced their professional expertise. © 2016 The Author(s).

  11. Human Resource Managements as a part of the Human Factors Management Program(HFMP) for Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Kim, DaeHo; Lee, YongHee; Lee, JungWoon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Younggab [Korea Hydro and Nuclear Power Co. LTD, Daejeon (Korea, Republic of)

    2007-10-15

    Programs for the effective implementation and management of human factor issues in nuclear power plants (NPPs) should contain technical criteria, an establishment of a job process, and activities for job improvements and be a system through which human factors can be managed in an integrated way. Human factors to be managed should include those related to an operation of plants as well as those related to a plant design as mentioned in NUREG-0800(2004), NUREG- 0711(2004), and NUREG-0700(2002). Human factor items to be managed for an operation of plants are listed in the PSR (Periodic Safety Review) items defined in the Enforcement of Regulation of the Atomic Energy Act. They are procedures, a work management system including a shift work management, a qualification management of plant personnel, training, a work amount assessment, a MMI (Man Machine Interface), and the use of experience. Among these factors, factors related to a human resource management include work management systems and the status of a work management including shift work, a qualification management ensuring qualified workers on duty at all times, and the systems for and the status of training and education. This paper addresses the scope of a human resource management, guidelines and procedures to be developed for a human resource management, and considerations critical in the development of guidelines and procedures.

  12. Impact of an Educational Program to Reduce Healthcare Resources in Community-Acquired Pneumonia: The EDUCAP Randomized Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Jordi Adamuz

    Full Text Available Additional healthcare visits and rehospitalizations after discharge are frequent among patients with community-acquired pneumonia (CAP and have a major impact on healthcare costs. We aimed to determine whether the implementation of an individualized educational program for hospitalized patients with CAP would decrease subsequent healthcare visits and readmissions within 30 days of hospital discharge.A multicenter, randomized trial was conducted from January 1, 2011 to October 31, 2014 at three hospitals in Spain. We randomly allocated immunocompetent adults patients hospitalized for CAP to receive either an individualized educational program or conventional information before discharge. The educational program included recommendations regarding fluid intake, adherence to drug therapy and preventive vaccines, knowledge and management of the disease, progressive adaptive physical activity, and counseling for alcohol and smoking cessation. The primary trial endpoint was a composite of the frequency of additional healthcare visits and rehospitalizations within 30 days of hospital discharge. Intention-to-treat analysis was performed.We assigned 102 patients to receive the individualized educational program and 105 to receive conventional information. The frequency of the composite primary end point was 23.5% following the individualized program and 42.9% following the conventional information (difference, -19.4%; 95% confidence interval, -6.5% to -31.2%; P = 0.003.The implementation of an individualized educational program for hospitalized patients with CAP was effective in reducing subsequent healthcare visits and rehospitalizations within 30 days of discharge. Such a strategy may help optimize available healthcare resources and identify post-acute care needs in patients with CAP.Controlled-Trials.com ISRCTN39531840.

  13. Endangered species and cultural resources program Naval petroleum Reserves in California. Annual report FY96

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    In FY96, Enterprise Advisory Services, Inc. (EASI) continued to support efforts to protect endangered species and cultural resources at the Naval Petroleum Reserves in California (NPRC). These efforts are conducted to ensure NPRC compliance with regulations regarding the protection of listed species and cultural resources on federal properties. Population monitoring activities were conducted for San Joaquin kit foxes, giant kangaroo rats, blunt-nosed leopard lizards, and Hoover`s wooly-star. Kit fox abundance and distribution was assessed by live-trapping over a 329-km{sup 2} area. Kit fox reproduction and mortality were assessed by radiocollaring and monitoring 22 adults and two pups. Reproductive success and litter size were determined through live-trapping and den observations. Rates and sources of kit fox mortality were assessed by recovering dead radiocollared kit foxes and conducting necropsies to determine cause of death. Abundance of coyotes and bobcats, which compete with kit foxes, was determined by conducting scent station surveys. Kit fox diet was assessed through analysis of fecal samples collected from live-trapped foxes. Abundance of potential prey for kit foxes was determined by conducting transect surveys for lagornorphs and live-trapping small mammals.

  14. Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status.

    Science.gov (United States)

    Granja, Sara; Marchiq, Ibtissam; Le Floch, Renaud; Moura, Conceição Souto; Baltazar, Fátima; Pouysségur, Jacques

    2015-03-30

    Most cancers rely on aerobic glycolysis to generate energy and metabolic intermediates. To maintain a high glycolytic rate, cells must efficiently export lactic acid through the proton-coupled monocarboxylate transporters (MCT1/4). These transporters require a chaperone, CD147/BASIGIN (BSG) for trafficking to the plasma membrane and function.To validate the key role of these transporters in lung cancer, we first analysed the expression of MCT1/4 and BSG in 50 non-small lung cancer (NSCLC) cases. These proteins were specifically upregulated in tumour tissues. We then disrupted BSG in three NSCLC cell lines (A549, H1975 and H292) via 'Zinc-Finger Nucleases'. The three homozygous BSG-/- cell lines displayed a low MCT activity (10- to 5-fold reduction, for MCT1 and MCT4, respectively) compared to wild-type cells. Consequently, the rate of glycolysis, compared to the wild-type counterpart, was reduced by 2.0- to 3.5-fold, whereas the rate of respiration was stimulated in BSG-/- cell lines. Both wild-type and BSG-null cells were extremely sensitive to the mitochondria inhibitor metformin/phenformin in normoxia. However, only BSG-null cells, independently of their LKB1 status, remained sensitive to biguanides in hypoxia in vitro and tumour growth in nude mice. Our results demonstrate that inhibiting glycolysis by targeting lactic acid export sensitizes NSCLC to phenformin.

  15. Cinnamon extract enhances glucose uptake in 3T3-L1 adipocytes and C2C12 myocytes by inducing LKB1-AMP-activated protein kinase signaling.

    Directory of Open Access Journals (Sweden)

    Yan Shen

    Full Text Available We previously demonstrated that cinnamon extract (CE ameliorates type 1 diabetes induced by streptozotocin in rats through the up-regulation of glucose transporter 4 (GLUT4 translocation in both muscle and adipose tissues. This present study was aimed at clarifying the detailed mechanism(s with which CE increases the glucose uptake in vivo and in cell culture systems using 3T3-L1 adipocytes and C2C12 myotubes in vitro. Specific inhibitors of key enzymes in insulin signaling and AMP-activated protein kinase (AMPK signaling pathways, as well as small interference RNA, were used to examine the role of these kinases in the CE-induced glucose uptake. The results showed that CE stimulated the phosphorylation of AMPK and acetyl-CoA carboxylase. An AMPK inhibitor and LKB1 siRNA blocked the CE-induced glucose uptake. We also found for the first time that insulin suppressed AMPK activation in the adipocyte. To investigate the effect of CE on type 2 diabetes in vivo, we further performed oral glucose tolerance tests and insulin tolerance tests in type 2 diabetes model rats administered with CE. The CE improved glucose tolerance in oral glucose tolerance tests, but not insulin sensitivity in insulin tolerance test. In summary, these results indicate that CE ameliorates type 2 diabetes by inducing GLUT4 translocation via the AMPK signaling pathway. We also found insulin antagonistically regulates the activation of AMPK.

  16. Cinnamon extract enhances glucose uptake in 3T3-L1 adipocytes and C2C12 myocytes by inducing LKB1-AMP-activated protein kinase signaling.

    Science.gov (United States)

    Shen, Yan; Honma, Natsumi; Kobayashi, Katsuya; Jia, Liu Nan; Hosono, Takashi; Shindo, Kazutoshi; Ariga, Toyohiko; Seki, Taiichiro

    2014-01-01

    We previously demonstrated that cinnamon extract (CE) ameliorates type 1 diabetes induced by streptozotocin in rats through the up-regulation of glucose transporter 4 (GLUT4) translocation in both muscle and adipose tissues. This present study was aimed at clarifying the detailed mechanism(s) with which CE increases the glucose uptake in vivo and in cell culture systems using 3T3-L1 adipocytes and C2C12 myotubes in vitro. Specific inhibitors of key enzymes in insulin signaling and AMP-activated protein kinase (AMPK) signaling pathways, as well as small interference RNA, were used to examine the role of these kinases in the CE-induced glucose uptake. The results showed that CE stimulated the phosphorylation of AMPK and acetyl-CoA carboxylase. An AMPK inhibitor and LKB1 siRNA blocked the CE-induced glucose uptake. We also found for the first time that insulin suppressed AMPK activation in the adipocyte. To investigate the effect of CE on type 2 diabetes in vivo, we further performed oral glucose tolerance tests and insulin tolerance tests in type 2 diabetes model rats administered with CE. The CE improved glucose tolerance in oral glucose tolerance tests, but not insulin sensitivity in insulin tolerance test. In summary, these results indicate that CE ameliorates type 2 diabetes by inducing GLUT4 translocation via the AMPK signaling pathway. We also found insulin antagonistically regulates the activation of AMPK.

  17. Development of a technical assistance framework for building organizational capacity of health programs in resource-limited settings.

    Science.gov (United States)

    Reyes, E Michael; Sharma, Anjali; Thomas, Kate K; Kuehn, Chuck; Morales, José Rafael

    2014-09-17

    Little information exists on the technical assistance needs of local indigenous organizations charged with managing HIV care and treatment programs funded by the US President's Emergency Plan for AIDS Relief (PEPFAR). This paper describes the methods used to adapt the Primary Care Assessment Tool (PCAT) framework, which has successfully strengthened HIV primary care services in the US, into one that could strengthen the capacity of local partners to deliver priority health programs in resource-constrained settings by identifying their specific technical assistance needs. Qualitative methods and inductive reasoning approaches were used to conceptualize and adapt the new Clinical Assessment for Systems Strengthening (ClASS) framework. Stakeholder interviews, comparisons of existing assessment tools, and a pilot test helped determine the overall ClASS framework for use in low-resource settings. The framework was further refined one year post-ClASS implementation. Stakeholder interviews, assessment of existing tools, a pilot process and the one-year post- implementation assessment informed the adaptation of the ClASS framework for assessing and strengthening technical and managerial capacities of health programs at three levels: international partner, local indigenous partner, and local partner treatment facility. The PCAT focus on organizational strengths and systems strengthening was retained and implemented in the ClASS framework and approach. A modular format was chosen to allow the use of administrative, fiscal and clinical modules in any combination and to insert new modules as needed by programs. The pilot led to refined pre-visit planning, informed review team composition, increased visit duration, and restructured modules. A web-based toolkit was developed to capture three years of experiential learning; this kit can also be used for independent implementation of the ClASS framework. A systematic adaptation process has produced a qualitative framework that can

  18. Assessing the twinning model in the Rwandan Human Resources for Health Program: goal setting, satisfaction and perceived skill transfer.

    Science.gov (United States)

    Ndenga, Esperance; Uwizeye, Glorieuse; Thomson, Dana R; Uwitonze, Eric; Mubiligi, Joel; Hedt-Gauthier, Bethany L; Wilkes, Michael; Binagwaho, Agnes

    2016-01-28

    Because of the shortage of health professionals, particularly in specialty areas, Rwanda initiated the Human Resources for Health (HRH) Program. In this program, faculty from United States teaching institutions (USF) "twin" with Rwandan Faculty (RF) to transfer skills. This paper assesses the twinning model, exploring USF and RF goal setting, satisfaction and perceptions of the effectiveness of skill transfer within the twinning model. All USF and RF in the HRH Program from August 2012-May 2014 were invited to participate. An 85-item questionnaire for USF and 71-item questionnaire for RF were administered via Survey Monkey in April and May 2014. Associations among primary outcomes were assessed and factors related with outcomes were modeled using logistic regression. Most RF and USF reported setting goals with their twin (89% and 71%, respectively). Half of RF (52%) reported effective skill transfer compared to 10% of USF. Only 38% of RF and 28% of USF reported being very satisfied with the twinning model. There was significant overlap in the three operational outcomes. For RF, the following factors were associated with outcomes: for effective skill transfer, being able to communicate in a common language and working at a nursing site outside of Kigali; and for satisfaction, 7+ years of professional experience and being part of a male RF-female USF twin pair. For USF, the following factors were associated with outcomes: for setting goals, prior teaching experience; and for satisfaction, experience in low resource settings for one month or less and feeling that HRH promotes a culture of respect. Twinning is the cornerstone of the HRH Program in Rwanda. These findings helped the HRH team identify key areas to improve the twinning experience including better recruitment and orientation of USF and RF, consideration of additional factors during the twinning process, provide language training support, facilitate joint twin activities and cross-cultural training and

  19. Hydrologic Resources Management Program and Underground Test Area Project FY 2000 Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Davisson, M L; Eaton, G F; Hakemi, N L; Hudson, G B; Hutcheon, I D; Lau, C A; Kersting, A B; Kenneally, J M; Moran, J E; Phinney, D L; Rose, T P; Smith, D K; Sylwester, E R; Wang, L; Williams, R; Zavarin, M

    2001-07-01

    This report highlights the results of FY 2000 technical studies conducted by the Analytical and Nuclear Chemistry Division (ANCD) at Lawrence Livermore National Laboratory (LLNL) in support of the Hydrology and Radionuclide Migration Program (HRMP) and Underground Test Area (UGTA) Project. This is the latest in a series of annual reports published by LLNL-ANCD to document recent investigations of radionuclide migration and transport processes at the Nevada Test Site (NTS). The HRMP is sponsored by Defense Programs (DP) at the U.S. Department of Energy, Nevada Operations Office (DOENV), and supports DP operations at the NTS through studies of radiochemical and hydrologic processes that are relevant to the DP mission. Other organizations that support the HRMP include Los Alamos National Laboratory (LANL), the U.S. Geological Survey (USGS), the Desert Research Institute (DRI) of the University of Nevada, the U.S. Environmental Protection Agency (EPS), and Bechtel Nevada (BN). The UGTA Project is sponsored by the Environmental Management (EM) program at DOENV; its goal is to determine the extent of radionuclide contamination in groundwater resulting from underground nuclear testing at the NTS. The project strategy follows guidelines set forth in a Federal Facilities Agreement and Consent Order between the U.S. Department of Energy, the U.S. Department of Defense, and the State of Nevada. Participating contractors include LLNL (both ANCD and the Energy and Environmental Sciences Directorate), LANL, USGS, DRI, BN, and IT Corporation (with subcontract support from Geotrans Inc.).

  20. Yucca Mountain Biological Resources Monitoring Program. Progress report, January 1994--December 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    The US Department of Energy (DOE) is required by the Nuclear Waste Policy Act of 1982 (as amended in 1987) to study and characterize the suitability of Yucca Mountain as a potential geological repository for high-level nuclear waste. During site characterization, the DOE will conduct a variety of geotechnical, geochemical, geological, and hydrological studies to determine the suitability of Yucca Mountain as a potential repository. To ensure that site characterization activities do not adversely affect the environment at Yucca Mountain, a program has been implemented to monitor and mitigate potential impacts and ensure activities comply with applicable environmental regulations. This report describes the activities and accomplishments of EG and G Energy Measurements, Inc. (EG and G/EM) from January 1994 through December 1994 for six program areas within the Terrestrial Ecosystem component of the environmental program for the Yucca Mountain Site Characterization Project (YMP): Site Characterization Effects, Desert Tortoises (Gopherus agassizii), Habitat Reclamation, Monitoring and Mitigation, Radiological Monitoring, and Biological Support.

  1. Gulf Coast geopressured-geothermal program summary report compilation. Volume 2-B: Resource description, program history, wells tested, university and company based research, site restoration

    Energy Technology Data Exchange (ETDEWEB)

    John, C.J.; Maciasz, G.; Harder, B.J.

    1998-06-01

    The US Department of Energy established a geopressured-geothermal energy program in the mid 1970`s as one response to America`s need to develop alternate energy resources in view of the increasing dependence on imported fossil fuel energy. This program continued for 17 years and approximately two hundred million dollars were expended for various types of research and well testing to thoroughly investigate this alternative energy source. This volume describes the following studies: Design well program; LaFourche Crossing; MG-T/DOE Amoco Fee No. 1 (Sweet Lake); Environmental monitoring at Sweet Lake; Air quality; Water quality; Microseismic monitoring; Subsidence; Dow/DOE L.R. Sweezy No. 1 well; Reservoir testing; Environmental monitoring at Parcperdue; Air monitoring; Water runoff; Groundwater; Microseismic events; Subsidence; Environmental consideration at site; Gladys McCall No. 1 well; Test results of Gladys McCall; Hydrocarbons in production gas and brine; Environmental monitoring at the Gladys McCall site; Pleasant Bayou No. 2 well; Pleasant Bayou hybrid power system; Environmental monitoring at Pleasant Bayou; and Plug abandonment and well site restoration of three geopressured-geothermal test sites. 197 figs., 64 tabs.

  2. Cornell University remote sensing program. [selected research projects in land and water resource management

    Science.gov (United States)

    Liang, T.; Belcher, D. J.; Mcnair, A. J.

    1974-01-01

    The major activities of the program staff from December 1, 1973 to May 31, 1974 are reported and include: (1) communication and instruction; (2) data and facilities; (3) research completed; (4) research in progress; (5) selected correspondence; (6) grant sponsored travel; and (7) seminars and newsletters. Detailed information and maps are given for the following selected projects: (1) ERTS mapping of waterways in the Tug Hill region of New York State; (2) photo-archeological investigation of Great Gully, New York; and (3) evaluation of selected highway impacts using aerial photography.

  3. "Pushing the Limits": Rethinking Motor and Cognitive Resources After a Highly Challenging Balance Training Program for Parkinson Disease.

    Science.gov (United States)

    Leavy, Breiffni; Roaldsen, Kirsti Skavberg; Nylund, Kamilla; Hagströmer, Maria; Franzén, Erika

    2017-01-01

    There is growing evidence for the positive effects of exercise training programs on balance control in Parkinson disease (PD). To be effective, balance training needs to be specific, progressive, and highly challenging. Little evidence exists, however, for how people with PD-related balance impairments perceive highly challenging and progressive balance training programs with dual-task components. The purpose of this study was to explore and describe perceptions of a highly challenging balance training program among people with mild to moderate PD. This study was qualitative in nature. In-depth interviews were conducted with 13 individuals with mild to moderate PD who had participated in a highly challenging balance training program. Interview transcripts were analyzed using qualitative content analysis, with an inductive approach. The analysis revealed 3 subthemes concerning participants' perceptions of highly challenging and progressive balance training: (1) movement to counter the disease, (2) dual-task training in contrast to everyday strategies, and (3) the struggle to maintain positive effects. The first subtheme reflects how physical activity was used as a short-term and long-term strategy for counteracting PD symptoms and their progression. The second subtheme incorporates the described experiences of being maximally challenged in a secure and supportive group environment, circumstances that stood in contrast to participants' everyday lives. The third subtheme describes participants' long-term struggle to maintain program effects on cognitive and physical function in the face of disease progression. Interpretation of the underlying patterns of these subthemes resulted in one overarching theme: training at the limits of balance capacity causes a rethinking motor and cognitive resources. The findings of this study cannot be considered to reflect the beliefs of those with weaker or negative beliefs concerning physical activity or be transferred to those at

  4. Assessment of the US Department of Energy's Sustainable Energy Resources for Consumers Grant Program

    Energy Technology Data Exchange (ETDEWEB)

    Lenahan, Tim [APPRISE, Inc., Princeton, NJ (United States); Bausch, Daniel [APPRISE, Inc., Princeton, NJ (United States); Carroll, David [APPRISE, Inc., Princeton, NJ (United States); Tonn, Bruce Edward [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Rose, Erin M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hawkins, Beth A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-10-01

    This report presents the results of an assessment of the Sustainable Energy Resources for Consumers (SERC) grant program that was administered by the US Department of Energy Weatherization and Intergovernmental Program Office. Grants totaling $90 million were awarded to 101 local weatherization agencies located in 27 states. More than 15,000 housing units were touched by the SERC program. Close to 29,000 SERC technologies were installed and/or services delivered. The report summarizes the results of site visits to 27 agencies in which the following 14 technologies were observed: solar photovoltaic panels, solar hot water heaters, solar thermal air panels for space heating, tankless water heaters, heat pump water heaters, geothermal heat pumps, super-evaporative cooling systems, combination boilers and indirect water heaters, small-scale residential wind systems, cool roofs, masonry spray foam insulation, attic radiant barriers, mini-split heat pumps, and in-home energy monitors. The evaluation found that the national weatherization network is capable of installing and delivering a wide range of new and innovative technologies, but the usability and adoptability of some technologies may prove impractical for the weatherization network and the demographic for which it serves.

  5. Pygrass: An Object Oriented Python Application Programming Interface (API for Geographic Resources Analysis Support System (GRASS Geographic Information System (GIS

    Directory of Open Access Journals (Sweden)

    Marco Ciolli

    2013-03-01

    Full Text Available PyGRASS is an object-oriented Python Application Programming Interface (API for Geographic Resources Analysis Support System (GRASS Geographic Information System (GIS, a powerful open source GIS widely used in academia, commercial settings and governmental agencies. We present the architecture of the PyGRASS library, covering interfaces to GRASS modules, vector and raster data, with a focus on the new capabilities that it provides to GRASS users and developers. Our design concept of the module interface allows the direct linking of inputs and outputs of GRASS modules to create process chains, including compatibility checks, process control and error handling. The module interface was designed to be easily extended to work with remote processing services (Web Processing Service (WPS, Web Service Definition Language (WSDL/Simple Object Access Protocol (SOAP. The new object-oriented Python programming API introduces an abstract layer that opens the possibility to use and access transparently the efficient raster and vector functions of GRASS that are implemented in C. The design goal was to provide an easy to use, but powerful, Python interface for users and developers who are not familiar with the programming language C and with the GRASS C-API. We demonstrate the capabilities, scalability and performance of PyGRASS with several dedicated tests and benchmarks. We compare and discuss the results of the benchmarks with dedicated C implementations.

  6. Employee assistance programs: a workplace resource to address intimate partner violence.

    Science.gov (United States)

    Pollack, Keshia M; Austin, Whitney; Grisso, Jeane Ann

    2010-04-01

    Intimate partner violence (IPV) is a major public health problem with significant impact on the workplace. Employee assistance programs (EAPs) are a confidential benefit to assist employees and their families with a variety of problems that may negatively affect their job performance. The purpose of this systematic review is to study the extant literature to identify articles that have explored the role of EAPs in addressing IPV. We searched Medline, PsychINFO, and Cumulative Index of Nursing and Allied Health Literature (CINAHL) for English-language papers that have explored how EAPs can address IPV. Articles published through 2008 were included. Our review yielded nine articles, mostly from EAP-centered journals. Nearly all of the studies were published before the year 2000 and primarily describe the need for EAPs to be more engaged in preventing violence against women. Most of the studies were commentaries, often using case reports to support recommendations on how EAPs could address IPV. Results from the two intervention studies revealed close connections between EAP clients being treated for alcoholism and IPV perpetration and the effectiveness of a standardized tool to identify EAP clients experiencing IPV. Research in this area is in its infancy, and more studies are needed to inform the formulation of evidence-based policies and programs that guide the role of EAPs in addressing IPV. The lack of research on how EAPs address IPV is alarming, as many employers state that they often refer employees affected by IPV to the EAP for assistance.

  7. Accounting for Uncertainty and Time Lags in Equivalency Calculations for Offsetting in Aquatic Resources Management Programs

    Science.gov (United States)

    Bradford, Michael J.

    2017-10-01

    Biodiversity offset programs attempt to minimize unavoidable environmental impacts of anthropogenic activities by requiring offsetting measures in sufficient quantity to counterbalance losses due to the activity. Multipliers, or offsetting ratios, have been used to increase the amount of offsets to account for uncertainty but those ratios have generally been derived from theoretical or ad-hoc considerations. I analyzed uncertainty in the offsetting process in the context of offsetting for impacts to freshwater fisheries productivity. For aquatic habitats I demonstrate that an empirical risk-based approach for evaluating prediction uncertainty is feasible, and if data are available appropriate adjustments to offset requirements can be estimated. For two data-rich examples I estimate multipliers in the range of 1.5:1 - 2.5:1 are sufficient to account for the uncertainty in the prediction of gains and losses. For aquatic habitats adjustments for time delays in the delivery of offset benefits can also be calculated and are likely smaller than those for prediction uncertainty. However, the success of a biodiversity offsetting program will also depend on the management of the other components of risk not addressed by these adjustments.

  8. A Review of 10 Years of Vasectomy Programming and Research in Low-Resource Settings.

    Science.gov (United States)

    Shattuck, Dominick; Perry, Brian; Packer, Catherine; Chin Quee, Dawn

    2016-12-23

    Vasectomy is a highly effective and safe contraceptive method for couples who want to stop childbearing, but only 2.4% of men around the world use this method. We conducted an extensive review of the vasectomy research literature and programmatic reports, published between April 2005 and April 2015, to synthesize barriers and facilitators to vasectomy adoption. Of the more than 230 documents initially retrieved in our search, we ultimately included 75 documents in our review and synthesized the findings according to the Supply-Enabling Environment-Demand (SEED) Programming Model. Regarding promoting demand for vasectomy services, we found there was a general lack of awareness about the method among both men and women, which often fueled erroneous assumptions about how vasectomy affects men. Several types of programmatic activities directly addressed knowledge gaps and negative misperceptions, including community-based and mass media communications, employer-based promotion, and group counseling. For supply of services, the lack of or inaccurate knowledge about vasectomy was also prevalent among providers, particularly among community-based health workers. Programmatic activities to improve service delivery included the use of evidence-based vasectomy techniques such as no-scalpel vasectomy, whole-site trainings, task shifting, cascade training, and mobile outreach. Finally, programmatic approaches to building a more enabling environment included engagement of governments and other community and religious leaders as well as campaigns with gender transformative messaging that countered common myths and encouraged men's positive engagement in family planning and reproductive health. In summary, a successful vasectomy program is comprised of the mutually reinforcing components of continual demand for services and access to and supply of well-trained providers. In addition, there is an underlying need for enabling policies within the cultural and gender environments

  9. Sharing programming resources between Bio* projects through remote procedure call and native call stack strategies.

    Science.gov (United States)

    Prins, Pjotr; Goto, Naohisa; Yates, Andrew; Gautier, Laurent; Willis, Scooter; Fields, Christopher; Katayama, Toshiaki

    2012-01-01

    Open-source software (OSS) encourages computer programmers to reuse software components written by others. In evolutionary bioinformatics, OSS comes in a broad range of programming languages, including C/C++, Perl, Python, Ruby, Java, and R. To avoid writing the same functionality multiple times for different languages, it is possible to share components by bridging computer languages and Bio* projects, such as BioPerl, Biopython, BioRuby, BioJava, and R/Bioconductor. In this chapter, we compare the two principal approaches for sharing software between different programming languages: either by remote procedure call (RPC) or by sharing a local call stack. RPC provides a language-independent protocol over a network interface; examples are RSOAP and Rserve. The local call stack provides a between-language mapping not over the network interface, but directly in computer memory; examples are R bindings, RPy, and languages sharing the Java Virtual Machine stack. This functionality provides strategies for sharing of software between Bio* projects, which can be exploited more often. Here, we present cross-language examples for sequence translation, and measure throughput of the different options. We compare calling into R through native R, RSOAP, Rserve, and RPy interfaces, with the performance of native BioPerl, Biopython, BioJava, and BioRuby implementations, and with call stack bindings to BioJava and the European Molecular Biology Open Software Suite. In general, call stack approaches outperform native Bio* implementations and these, in turn, outperform RPC-based approaches. To test and compare strategies, we provide a downloadable BioNode image with all examples, tools, and libraries included. The BioNode image can be run on VirtualBox-supported operating systems, including Windows, OSX, and Linux.

  10. Review: The placenta and developmental programming: balancing fetal nutrient demands with maternal resource allocation.

    Science.gov (United States)

    Burton, G J; Fowden, A L

    2012-02-01

    The placenta evolved to support development of the fetus, and so potentially plays a key role in the aetiology of developmental programming through its impact on nutrient transfer. Placental transport efficiency depends on a variety of parameters, including surface area for exchange, thickness of the interhaemal membrane and density of transporter proteins inserted into the trophoblast membranes. Here, we review recent studies that tested whether adaptations of placental efficiency are induced in the mouse placenta when maternal nutrient supply and fetal demand are manipulated experimentally. Naturally small placentas, and those exposed to maternal undernutrition, displayed structural changes indicative of accelerated maturation at E16, with enlargement of the labyrinth exchange zone at the expense of the endocrine junctional zone. These changes were associated with increased transport of a non-metabolisable amino acid analogue per gram of placenta, and expression of genes encoding specific System A transporters. Up-regulation of transporters was also observed when a mismatch between placental size and fetal demand was generated through genetic manipulation of the Igf2/H19 axis. Conversely, overgrowth of the placenta induced by deletion of H19 resulted in reduced transport capacity and expression of transporter genes. We conclude that under conditions when the maternal nutrient supply or placental size may be limiting for normal fetal growth, the placenta adapts so as to increase its transport capacity. Hence, it ameliorates the effects of environmental cues that would otherwise lead to more extensive developmental programming. The P0 transcript of Igf2 appears to be a strong candidate as a mediator of these adaptations in the mouse. Copyright © 2012 Elsevier Ltd. All rights reserved.

  11. Green Infrastructure Research Promotes Students' Deeper Interest in Core Courses of a Water Resources Program

    Science.gov (United States)

    Yerk, W.; Montalto, F. A.; Foti, R.

    2015-12-01

    As one of most innovative among low impact development technologies, Green Infrastructure (GI) is a new technology that presents a range of potential research opportunities. Inherently linked to sustainability, urban quality of life, resilience, and other such topics, GI also represents a unique opportunity to highlight the social relevance of practical STEM research to undergraduate students. The nature of research on urban GI, in fact, as well as the accessibility of the GI sites, allows students to combine hands-on experience with theoretical work. Furthermore, the range of scales of the projects is such that they can be managed within a single term, but does not preclude longer engagement. The Sustainable Water Resource Engineering lab at Drexel University is engaged in two types of GI research outside the classroom. One type is a research co-op research internship. The second is a selective university-wide faculty-mentored summer scholarship STAR (Students Tackling Advanced Research) specifically designed for freshmen. The research projects we developed for those curricula can be accomplished by undergraduate students, but also address a larger research need in this emerging field. The research tasks have included identifying and calibrating affordable instruments, designing and building experimental setups, and monitoring and evaluating performance of GI sites. The work also promoted deeper understanding of the hydrological processes and initiated learning beyond the students' current curricula. The practice of the Lab's research being embedded into the educational process receives positive feedback from the students and achieves meaningful and long-lasting learning objectives. The experience helps students to students acquire hands-on experience, improves their metacognition and evidence-based inquiring into real-world problems, and further advances decision-making and communication skills.

  12. Childhood trauma fatality and resource allocation in injury control programs in a developing country

    Science.gov (United States)

    Roudsari, Bahman S; Shadman, Mazyar; Ghodsi, Mohammad

    2006-01-01

    Background Only a few studies have addressed the trimodal distribution of childhood trauma fatalities in lesser developed countries. We conducted this study to evaluate pre-hospital, Emergency Department (ED) and in-hospital distribution of childhood injury-related death for each mechanism of injury in Tehran, Iran. This information will be used for the efficient allocation of the limited injury control resources in the city. Methods We used Tehran's Legal Medicine Organization (LMO) database. This is the largest and the most complete database that receives information about trauma fatalities from more than 100 small and large hospitals in Tehran. We reviewed all the medical records and legal documents of the deceased registered in LMO from September 1999 to September 2000. Demographic and injury related characteristics of the children 15 years old or younger were extracted from the records. Results Ten percent of the 4,233 trauma deaths registered in LMO occurred among children 15 years old or younger. Motor vehicle crashes (MVCs) (50%), burns (18%), falls (6%) and poisonings (6%) were the most common mechanisms of unintentional fatal injuries. Prehospital, emergency department and hospital deaths comprised 42%, 20% and 37% of the trauma fatalities, respectively. While, more than 80% of fatal injuries due to poisoning and drowning occurred in prehospital setting, 92% of burn-related fatalities happened after hospital admission. Conclusion Injury prevention is the single most important solution for controlling trauma fatalities due to poisoning and drowning. Improvements in the quality of care in hospitals and intensive care units might substantially alleviate the magnitude of the problem due to burns. Improvements in prehospital and ED care might significantly decrease MVC and falls-related fatalities. PMID:16670023

  13. Raising a Red Flag on Dating Violence: Evaluation of a Low-Resource, College-Based Bystander Behavior Intervention Program.

    Science.gov (United States)

    Borsky, Amanda E; McDonnell, Karen; Turner, Monique Mitchell; Rimal, Rajiv

    2016-03-09

    Encouraging bystanders to intervene safely and effectively in situations that could escalate to violence-known as bystander behavior programs-is a growing yet largely untested strategy to prevent dating violence. Using a quasi-experimental design, we evaluate a low-resource, low-intensity intervention aimed at preventing dating violence among college students. The integrated behavioral model (IBM) was used to guide the evaluation. We also assess which IBM variables were most strongly associated with bystander behaviors. Participants were drawn from two Virginia colleges that predominantly train females in the health profession sciences. The intervention group (n = 329) participated in a university-wide bystander behavior intervention consisting of a 30-min presentation on dating violence at new-student orientation and a week-long "red flag" social marketing campaign on campus to raise awareness of dating violence. Controlling for changes at the comparison university, results showed an increase in bystander behaviors, such as encouraging a friend who may be in an abusive relationship to get help, after the intervention and adjusting for potential confounders (increase of 1.41 bystander behaviors, p = .04). However, no significant changes were found for bystander intentions, self-efficacy, social norms, or attitudes related to dating violence from pre- to post-intervention. Self-efficacy had a direct relationship with bystander behaviors. Results suggest that low-resource interventions have a modest effect on increasing bystander behaviors. However, higher resource interventions likely are needed for a larger impact, especially among students who already demonstrate strong baseline intentions to intervene and prevent dating violence. © The Author(s) 2016.

  14. In Situ Resource Utilization Technology Research and Facilities Supporting the NASA's Human Systems Research and Technology Life Support Program

    Science.gov (United States)

    Schlagheck, Ronald A.; Sibille, Laurent; Sacksteder, Kurt; Owens, Chuck

    2005-01-01

    The NASA Microgravity Science program has transitioned research required in support of NASA s Vision for Space Exploration. Research disciplines including the Materials Science, Fluid Physics and Combustion Science are now being applied toward projects with application in the planetary utilization and transformation of space resources. The scientific and engineering competencies and infrastructure in these traditional fields developed at multiple NASA Centers and by external research partners provide essential capabilities to support the agency s new exploration thrusts including In-Situ Resource Utilization (ISRU). Among the technologies essential to human space exploration, the production of life support consumables, especially oxygen and; radiation shielding; and the harvesting of potentially available water are realistically achieved for long-duration crewed missions only through the use of ISRU. Ongoing research in the physical sciences have produced a body of knowledge relevant to the extraction of oxygen from lunar and planetary regolith and associated reduction of metals and silicon for use meeting manufacturing and repair requirements. Activities being conducted and facilities used in support of various ISRU projects at the Glenn Research Center and Marshall Space Flight Center will be described. The presentation will inform the community of these new research capabilities, opportunities, and challenges to utilize their materials, fluids and combustion science expertise and capabilities to support the vision for space exploration.

  15. Managing the Ocean Resources of the United States: The Role of the Federal Marine Sanctuaries Program

    Science.gov (United States)

    Pontecorvo, Guilio

    In 1969, the Straton Commission report provided a plan for the systematic development of a national policy on marine affairs. In subsequent years no such systematic approach to a coherent marine policy was undertaken. The de facto policy approach of the 1970s was a plethora of individual legislative acts which provided specific de jure rules, but which left administrators the complex problems of working out the administration of areas of overlapping authority, with conflicting or inconsistent goals and jurisdiction. The major acts of the 1970s, the Fishery Conservation a n d Management Act of 1976; Mammals and Non-Migratory Birds—The Marine Mammal Protection Act of 1972; Coastal Zone Management Act of 1972; Endangered Species Act of 1973; Marine Protection, Research, and Sanctuaries Act of 1972; and others, are clear indications of a national commitment to regulation of the markets for the output from the ocean sector. But while the need for intervention in markets was clear to legislators, the failure to employ a systematic approach and provide guidelines adequate to permit the rationalization of complex problems doomed the piecemeal approach to ocean policy to ever increasing administrative problems and ultimately to ineffective government programs.

  16. National Uranium Resource Evaluation program. Uranium geochemical survey in the Crystal City and Beeville Quadrangles, Texas

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, C.E.; Butz, T.R.; Cagle, G.W.; Kane, V.E.

    1977-02-11

    A uranium geochemical survey was conducted in the Crystal City and western half of the Beeville Quadrangles, Texas, an area of approximately 34,000 km/sup 2/. Using the Texas Gulf Coast Uranium Province as a study area, this survey demonstrates the applicability of a 2 phase hierarchical sampling program with multielement analysis of the samples for regional geochemical reconnaissance for uranium. Phase I samples of stream sediment, stream water, and well water were collected from drainage basins with a target drainage of 250 km/sup 2/ to identify uranium province lines which define the area in which closer spaced Phase II sampling should be conducted. Phase II samples of stream sediment, stream water, well water, and tree branches were collected from drainage basins with a target drainage of 25 km/sup 2/ in order to identify uranium district lines. Stream sediment, stream water, well water, and ash of tree branches were analyzed for approximately 25 parameters. The most useful sample type for identifying potential uranium mineralization in the Texas Gulf Coast is well water. Wells were found to accurately distinguish both province lines at Phase I sample spacing and district lines at Phase II sample spacing by several methods of evaluation. Results of the survey indicate that the concept of 2 phase sampling with multielement analyses of samples, developed by the ORGDP Project, may yield good results for the remainder of the area to be surveyed by ORGDP with modifications for different geologic regions.

  17. Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

    Science.gov (United States)

    Onken, Brian; Driscoll, Monica

    2010-01-01

    Metformin, a biguanide drug commonly used to treat type-2 diabetes, has been noted to extend healthspan of nondiabetic mice, but this outcome, and the molecular mechanisms that underlie it, have received relatively little experimental attention. To develop a genetic model for study of biguanide effects on healthspan, we investigated metformin impact on aging Caenorhabditis elegans. We found that metformin increases nematode healthspan, slowing lipofuscin accumulation, extending median lifespan, and prolonging youthful locomotory ability in a dose-dependent manner. Genetic data suggest that metformin acts through a mechanism similar to that operative in eating-impaired dietary restriction (DR) mutants, but independent of the insulin signaling pathway. Energy sensor AMPK and AMPK-activating kinase LKB1, which are activated in mammals by metformin treatment, are essential for health benefits in C. elegans, suggesting that metformin engages a metabolic loop conserved across phyla. We also show that the conserved oxidative stress-responsive transcription factor SKN-1/Nrf2 is essential for metformin healthspan benefits in C. elegans, a mechanistic requirement not previously described in mammals. skn-1, which functions in nematode sensory neurons to promote DR longevity benefits and in intestines for oxidative stress resistance lifespan benefits, must be expressed in both neurons and intestines for metformin-promoted healthspan extension, supporting that metformin improves healthy middle-life aging by activating both DR and antioxidant defense longevity pathways. In addition to defining molecular players operative in metformin healthspan benefits, our data suggest that metformin may be a plausible pharmacological intervention to promote healthy human aging. PMID:20090912

  18. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1.

    Directory of Open Access Journals (Sweden)

    Brian Onken

    2010-01-01

    Full Text Available Metformin, a biguanide drug commonly used to treat type-2 diabetes, has been noted to extend healthspan of nondiabetic mice, but this outcome, and the molecular mechanisms that underlie it, have received relatively little experimental attention. To develop a genetic model for study of biguanide effects on healthspan, we investigated metformin impact on aging Caenorhabditis elegans. We found that metformin increases nematode healthspan, slowing lipofuscin accumulation, extending median lifespan, and prolonging youthful locomotory ability in a dose-dependent manner. Genetic data suggest that metformin acts through a mechanism similar to that operative in eating-impaired dietary restriction (DR mutants, but independent of the insulin signaling pathway. Energy sensor AMPK and AMPK-activating kinase LKB1, which are activated in mammals by metformin treatment, are essential for health benefits in C. elegans, suggesting that metformin engages a metabolic loop conserved across phyla. We also show that the conserved oxidative stress-responsive transcription factor SKN-1/Nrf2 is essential for metformin healthspan benefits in C. elegans, a mechanistic requirement not previously described in mammals. skn-1, which functions in nematode sensory neurons to promote DR longevity benefits and in intestines for oxidative stress resistance lifespan benefits, must be expressed in both neurons and intestines for metformin-promoted healthspan extension, supporting that metformin improves healthy middle-life aging by activating both DR and antioxidant defense longevity pathways. In addition to defining molecular players operative in metformin healthspan benefits, our data suggest that metformin may be a plausible pharmacological intervention to promote healthy human aging.

  19. [Resource management: ICF-oriented exercise programs for patients with diabetes mellitus type 2. Chronic illnesses and biopsychosocial status].

    Science.gov (United States)

    Pfeifer, K; Huber, G; Baldus, A; Pöthig, D; Schüle, K

    2012-02-01

    Common health problems are increasing due to the combination of decreased physical activity demands in everyday life and demographic changes; thus, the importance of exercise therapy is increasing. The incidence and prevalence of today's predominant chronic diseases are directly related to physical activity. However, daily clinical routine does not stay abreast with these changes. The education of physicians, and thus their scope of action, is dominated by biomedical therapy concepts, predominantly drug therapy concepts. Differential and consolidated findings of modern exercise and sport science are astonishingly rare in the counselling and treatment portfolio of medical care. The present disease management program for persons with diabetes mellitus type 2 is a good example. Referring to this background, the authors address the new approach of "ICF-oriented exercise programs and biopsychosocial status." They present resource-related interventional strategies and health care concepts for chronic health disorders like the metabolic syndrome or diabetes mellitus type 2. The relevance and use of active health promotion and care - due to lifestyle- and age-related health problems of the population - will increase in importance and be more commonly recommended.

  20. Ecological and environmental data as under-utilized national resources: results of the TIE/ACCESS program

    Energy Technology Data Exchange (ETDEWEB)

    Armentano, T.V.; Loucks, O.L.

    1979-06-01

    The goal of The Institute of Energy (TIE) 1977 to 1979 ACCESS program was to define the national need for ecological and environmental data and the extent to which present data documentation and archiving are meeting this need. The principal steps focussed on current data documentation and research in government, private and academic sectors of the natural science technical community, particularly as they bear on the accessibility of environmental data to secondary users. The extent to which existing data services are satisfying the needs of data users also was emphasized. The results indicate that the potential contributions which existing data and models could make are not being achieved because of inconsistencies in data documentation, inadequate communication between data suppliers and data users, and a lack of overall coordination of the data bases in national research and monitoring programs. A nationally coordinated network is proposed which focuses on regional data centers and ties together the hierarchy of data bases (national, state, and local) with the broad spectrum of potential users. The network concept includes immediate development of a comprehensive catalog of data resources in each region, with later production of a data abstract journal as one of two methods for communicating between regional and local data centers and the user community.

  1. Hydrologic resources management program and underground test area FY 1999 progress report

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D K; Eaton, G F; Rose, T P; Moran, J E; Brachmann, A; McAninch, J E; Kersting, A B; Romanovski, V V; Martinelli, R E; Werner, J K Jr

    2000-07-01

    This report presents the results from fiscal year (FY) 1999 technical studies conducted by Lawrence Livermore National Laboratory (LLNL) as part of the Hydrology and Radionuclide Migration Program (HRMP) and Underground Test Area (UGTA) work-for-others project. This report is the latest in a series of annual reports published by LLNL to document the migration of radionuclides and controls of radionuclide movement at the Nevada Test Site. The FY 1999 studies highlighted in this report are: (1) Chapter 1 provides the results from flow-through leaching of nuclear melt glasses at 25 C and near-neutral pH using dilute bicarbonate groundwaters. (2) Chapter 2 reports on a summary of the size and concentration of colloidal material in NTS groundwaters. (3) Chapter 3 discusses the collaboration between LLNL/ANCD (Analytical and Nuclear Chemistry Division) and the Center for Accelerator Mass Spectrometry (CAMS) to develop a technique for analyzing NTS groundwater for 99-Technicium ({sup 99}Tc) using accelerator mass spectrometry (AMS). Since {sup 99}Tc is conservative like tritium in groundwater systems, and is not sorbed to geologic material, it has the potential for being an important tool for radionuclide migration studies. (4) Chapter 4 presents the results of secondary ion mass spectrometry measurements of the in-situ distribution of radionuclides in zeolitized tuffs from cores taken adjacent to nuclear test cavities and chimneys. In-situ measurements provide insight to the distribution of specific radionuclides on a micro-scale, mineralogical controls of radionuclide sorption, and identification of migration pathways (i.e., matrix diffusion, fractures). (5) Chapter 5 outlines new analytical techniques developed in LLNL/ANCD to study hydrologic problems at the NTS using inductively coupled plasma mass spectrometry (ICP-MS). With costs for thermal-ionization mass spectrometry (TIMS) increasing relative to sample preparation time and facility support, ICP-MS technology

  2. The Effectiveness of Empowerment Program on Increasing Self-Esteem, Learned Resourcefulness, and Coping Ways in Women Exposed to Domestic Violence.

    Science.gov (United States)

    Bahadir-Yilmaz, Emel; Öz, Fatma

    2017-10-13

    This study was conducted to assess the effectiveness of empowerment program on increasing self-esteem, learned resourcefulness, and coping ways in women exposed to domestic violence. This experimental study was conducted between October 2012 and June 2014 in the obstetrics and gynaecology departments of the Giresun Maternity Hospital, and at the Family Counseling Center (FCC) in Turkey. Sixty women who agreed to participate in the study were randomly assigned into two groups. Data were collected by the Coopersmith Self-Esteem Inventory (SEI), The Rosenbaum's Learned Resourcefulness Scale (RLRS), and the Ways of Coping Inventory (WCI). The assessment of the women before and after the empowerment program showed that women in the intervention group showed significant improvements in the SEI, RLRS, and WCI scores compared with controls. These results suggest that the empowerment program is an effective practice for increasing the levels of self-esteem, learned resourcefulness, and coping ways of women exposed to domestic violence.

  3. An inventory of Geothermal Resources in Nebraska: State-Coupled Program between US Department of Energy and The University of Nebraska. Final report, June 30, 1983

    Energy Technology Data Exchange (ETDEWEB)

    Gosnold, William D.; Eversoll, Duane, A.; Messenger, Karen A.; Carlson, Marvin P.

    1983-06-30

    The goal of the State Coupled Resource Assessment Program is to identify and evaluate geothermal resources in the state, particularly low-temperature potential. Eight tasks were identified and documented in this report as follows: (1) Bottom-hole Temperature Survey; (2) Heat Flow and Temperature Gradient Survey; (3) Data Translation studies; (4) Gravity Data; (5) Substate Regions; (6) Information Dissemination; (7) State Geothermal Map; (8) Reports. The project had three major products: (1) a map ''Geothermal Resources of Nebraska''; (2) a significant amount of thermal data collected and documented within the state; and (3) a series of publications, presentations and meetings.

  4. Essential Resources for Implementation and Sustainability of Evidence-Based Health Promotion Programs: A Mixed Methods Multi-Site Case Study.

    Science.gov (United States)

    Dattalo, M; Wise, M; Ford Ii, J H; Abramson, B; Mahoney, J

    2017-04-01

    As of October 2016, use of federal Older Americans Act funds for health promotion and disease prevention will be restricted to the Administration on Aging's criteria for high-level evidence-based health promotion programs. Dissemination of these programs to rural communities remains limited. Therefore a strong need exists to identify strategies that facilitate program implementation and sustainability. The objective of this study was to compare organizational readiness and implementation strategies used by rural communities that achieved varying levels of success in sustaining evidence-based health promotion programs for older adults. We utilized a qualitative multi-site case study design to analyze the longitudinal experiences of eight rural sites working to implement evidence-based health promotion program over 3 years (8/2012-7/2015). Multiple sources of data (interviews, documents, reports, surveys) from each site informed the analysis. We used conventional content analysis to conduct a cross-case comparison to identify common features of rural counties that successfully implemented and sustained their target evidence-based health promotion program. Readiness to implement evidence-based programs as low at baseline as all site leaders described needing to secure additional resources for program implementation. Sites that successfully utilized six essential resources implemented and sustained greater numbers of workshops: (1) External Partnerships, (2) Agency Leadership Commitment, (3) Ongoing Source of Workshop Leaders, (4) Health Promotion Coordination Tasks Assigned to Specific Staff, (5) Organizational Stability, and (6) Change Team Engagement. The six essential resources described in this study can help rural communities assess their readiness to implement health promotion programs and work secure the resources necessary for successful implementation.

  5. Establishing midwifery in low-resource settings: guidance from a mixed-methods evaluation of the Afghanistan midwifery education program.

    Science.gov (United States)

    Zainullah, Partamin; Ansari, Nasratullah; Yari, Khalid; Azimi, Mahmood; Turkmani, Sabera; Azfar, Pashtoon; LeFevre, Amnesty; Mungia, Jaime; Gubin, Rehana; Kim, Young-Mi; Bartlett, Linda

    2014-10-01

    The shortage of skilled birth attendants has been a key factor in the high maternal and newborn mortality in Afghanistan. Efforts to strengthen pre-service midwifery education in Afghanistan have increased the number of midwives from 467 in 2002 to 2954 in 2010. We analyzed the costs and graduate performance outcomes of the two types of pre-service midwifery education programs in Afghanistan that were either established or strengthened between 2002 and 2010 to guide future program implementation and share lessons learned. We performed a mixed-methods evaluation of selected midwifery schools between June 2008 and November 2010. This paper focuses on the evaluation's quantitative methods, which included (a) an assessment of a sample of midwifery school graduates (n=138) to measure their competencies in six clinical skills; (b) prospective documentation of the actual clinical practices of a subsample of these graduates (n=26); and (c) a costing analysis to estimate the resources required to educate students enrolled in these programs. For the clinical competency assessment and clinical practices components, two Institutes for Health Sciences (IHS) schools and six Community Midwifery Education (CME) schools; for the costing analysis, a different set of nine schools (two IHS, seven CME), all of which were funded by the US Agency for International Development. Midwives who had graduated from either IHS or CME schools. CME graduates (n=101) achieved an overall mean competency score of 63.2% (59.9-66.6%) on the clinical competency assessment compared to 57.3% (49.9-64.7%) for IHS graduates (n=37). Reproductive health activities accounted for 76% of midwives' time over an average of three months. Approximately 1% of childbirths required referral or resulted in maternal death. On the basis of known costs for the programs, the estimated cost of graduating a class with 25 students averaged US$298,939, or US$10,784 per graduate. The pre-service midwifery education experience of

  6. Earth resources cartography program

    Science.gov (United States)

    Colvocoresses, A. P.

    1972-01-01

    Progress is reported on efforts to develop techniques of using space vehicle and high altitude aircraft imagery in cartography projects. Major efforts were made to develop an operational system for isolating specified themes from the imagery.

  7. Optical pre-screening in breast screening programs: Can we identify women who benefit most from limited mammography resources?

    Science.gov (United States)

    Walter, Jane; Loshchenov, Maxim; Zhilkin, Vladimir; Peake, Rachel; Stone, Jennifer; Lilge, Lothar

    2017-04-01

    Background: In excess of 60% of all cancers are detected in low and middle-income countries, with breast cancer (BC) the dominant malignancy for women. Incidence rates continue to climb, most noticeably in the less than 50-year-old population. Expansion of mammography infrastructure and resources is lacking, resulting in over 60% of women diagnosed with stage III/IV BC in the majority of these countries. Optical Breast Spectroscopy (OBS) was shown to correlate well with mammographic breast density (MBD). OBS could aid breast screening programs in low- and middle-income countries by lowering the number of mammographs required for complete population coverage. However, its performance needs to be tested in large population trails to ensure high sensitivity and acceptable specificity. Methods: For the planned studies in low- and middle-income countries in different continents, online methods need to be implemented to monitor the performance and data collection by these devices, operated by trained nurses. Based on existing datasets, procedures were developed to validate an individual woman's data integrity and to identify operator errors versus system malfunctions. Results: Using a dataset comprising spectra from 360 women collected by 2 instruments in different locations and with 3 different trained operators, automated methods were developed to identify 100% of the source or photodetector malfunctions as well as incorrect calibrations and 96% of instances of insufficient tissue contact. Conclusions: Implementing the dataset validation locally in each instrument and tethered to a cloud database will allow the planned clinical trials to proceed.

  8. Planning of water resources management and pollution control for Heshui River watershed, China: A full credibility-constrained programming approach.

    Science.gov (United States)

    Zhang, Y M; Huang, G; Lu, H W; He, Li

    2015-08-15

    A key issue facing integrated water resources management and water pollution control is to address the vague parametric information. A full credibility-based chance-constrained programming (FCCP) method is thus developed by introducing the new concept of credibility into the modeling framework. FCCP can deal with fuzzy parameters appearing concurrently in the objective and both sides of the constraints of the model, but also provide a credibility level indicating how much confidence one can believe the optimal modeling solutions. The method is applied to Heshui River watershed in the south-central China for demonstration. Results from the case study showed that groundwater would make up for the water shortage in terms of the shrinking surface water and rising water demand, and the optimized total pumpage of groundwater from both alluvial and karst aquifers would exceed 90% of its maximum allowable levels when credibility level is higher than or equal to 0.9. It is also indicated that an increase in credibility level would induce a reduction in cost for surface water acquisition, a rise in cost from groundwater withdrawal, and negligible variation in cost for water pollution control. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. A Human Resource Development Action Plan for the Radiography Program Sponsored by Lincoln Land/St. John's Based on a View of the Radiographer of the Future.

    Science.gov (United States)

    Dowd, Steven B.

    The purpose of a practicum was to develop an effective and valid human resource development plan based on a view of the practitioner of the future. The targeted program was one in radiography (radiologic technology) co-sponsored by Lincoln Land Community College and St. John's Hospital (Illinois). A review of the literature was used to establish a…

  10. Career and Academic Resources in Bilingual Education Program for High School Students (Project CARIBE). Final Evaluation Report, 1992-93. OREA Report.

    Science.gov (United States)

    Ranadive, Jyoti

    Career and Academic Resources in Bilingual Education (Project CARIBE) was a federally funded program that served 70 limited-English-speaking, native Spanish-speaking students, largely immigrants, in two Brooklyn (New York) high schools. Participating students received instruction in English as a Second Language (ESL), native language arts (NLA),…

  11. Inclusion of Students with Special Education Needs in French as a Second Language Programs: A Review of Canadian Policy and Resource Documents

    Science.gov (United States)

    Muhling, Stefanie; Mady, Callie

    2017-01-01

    This article describes a document analysis of policy and resource documents pertaining to inclusion of students with special education needs (SSEN) in Canadian French as a Second Language (FSL) programs. By recognizing gaps and acknowledging advancements, we aim to inform current implementation and future development of inclusive policy. Document…

  12. Using Culture as a Resource in Mathematics: The Case of Four Mexican-American Prospective Teachers in a Bilingual After-School Program

    Science.gov (United States)

    Vomvoridi-Ivanovic, Eugenia

    2012-01-01

    This paper explores Mexican-American prospective teachers' use of culture--defined as social practices and shared experiences--as an instructional resource in mathematics. The setting is an after-school mathematics program for the children of Mexican heritage. Qualitative analysis of the prospective teachers' and children's interactions reveals…

  13. Final Report for the MANNRRSS II Program Management of Nevada's Natural Resources with Remote Sensing Systems, Beatty, NV

    Energy Technology Data Exchange (ETDEWEB)

    Lester Miller; Brian Horowitz; Chris Kratt; Tim Minor; Stephen F. Zitzer; James. V. Taranik; Zan L. Aslett; Todd O. Morken

    2009-06-04

    This document provides the Final Report on the Management of Nevada’s Natural Resources with Remote Sensing Systems (MANNRRSS) II program. This is a U.S. Department of Energy (DOE)-funded project tasked with utilizing hyperspectral and ancillary electro-optical instrumentation data to create an environmental characterization of an area directly adjacent to the Nevada Test Site (NTS).

  14. Assessing the Sustainability of Small Farmer Natural Resource Management Systems. A Critical Analysis of the MESMIS Program (1995-2010

    Directory of Open Access Journals (Sweden)

    Marta Astier

    2012-09-01

    Full Text Available Sustainability assessment oriented to improve current systems and practices is urgently needed, particularly in the context of small farmer natural resource management systems (NRMS. Unfortunately, social-ecological systems (SES theory, sustainability evaluation frameworks, and assessment methods are still foreign not only to farmers but to many researchers, students, NGOs, policy makers/operators, and other interested groups. In this paper we examine the main achievements and challenges of the MESMIS Program (Spanish acronym for Indicator-based Sustainability Assessment Framework, a 15-year ongoing effort with impact in 60 case studies and 20 undergraduate and graduate programs mainly in Ibero-America that is attempting to cope with the stated challenges. The MESMIS experience shows that it is possible to conduct sustainability assessments in the context of small farmers through a long-term, participatory, interdisciplinary, and multi-institutional approach that integrates a solid theoretical background, a field-tested operational framework, learning tools specifically devised to facilitate the understanding of sustainability as a multidimensional and dynamic concept, and a growing set of case studies to apply to and get feedback from users. Specifically, through the dissemination of the MESMIS assessment framework in a large set of case studies in a contrasting set of social-ecological contexts, we have been able to: (a characterize the NRMS, their subsystems, and their main interactions; (b link attributes, i.e., general systemic properties, with sustainability indicators to assess critical socioeconomic and environmental aspects of the NRMS; (c integrate indicators through multicriteria tools and to expose the multidimensional aspects of sustainability; (d propose an initial multiscale assessment to articulate processes and actors at different spatial scales; (e develop multimedia learning tools, i.e., Interactive-MESMIS, to help users

  15. ¿HOW ARE THE RESOURCES FOR FIGHTING POVERTY DISTRIBUTED? A REGIONAL ANALYSIS OF BUDGET ASSIGNING OF THE OPPORTUNITIES PROGRAM IN THE STATE OF PUEBLA, MEXICO

    Directory of Open Access Journals (Sweden)

    Mariana Betzaidet Cortés Sánchez

    2011-01-01

    Full Text Available Poverty is one of the most important issues in México. In order to face it, the government has developed social policies looking for more efficient ways to distribute financial resources through focused transfers towards vulnerable groups in marginated areas. The goal of this research was to analyze the social policy and specifically the distribution of financial resources in areas of the State of Puebla carried out by the program called Oportunidades in 2005. The analysis was done with information give by governmental institutions. The financial resources were mainly directed to the regions where the poorest population lived, nevertheless these resources were not enough to effectively fight poverty and revert the situation.

  16. Findings of an evaluation of public involvement programs associated with the development of a Land and Resource Management Plan for the Ouachita National Forest

    Energy Technology Data Exchange (ETDEWEB)

    Holthoff, M.G. [Pacific Northwest Lab., Richland, WA (United States); Howell, R.E. [Washington State Univ., Pullman, WA (United States)

    1993-08-01

    Federal regulations require the United States Forest Service (USFS) to integrate public input and values into decisions concerning land and resource management planning. The USFS has typically relied on traditional methods of involving the public, whereby public access and input to policy development are unilaterally controlled by the agency. Because of the highly political nature of land and resource management planning, such technocratic forms of public involvement and decision-making appear to be proving ineffective. This paper describes and evaluates two public involvement programs associated with the Ouachita National Forest`s (ONF) lengthy forest planning process. The research consisted of personal interviews with key program leaders and knowledgeable citizen participants, collection of secondary data, and a survey of citizen participants. Because of controversial planning decisions made during an initial planning process, the ONF was forced to re-enter the planning process in order to address unresolved planning issues and to conduct a more effective public involvement program. The supplemental planning process also resulted in a considerable degree of public contention. The survey revealed that although citizen participants were somewhat more satisfied with the supplemental public involvement program relative to the initial program, neither program was viewed as satisfactory. The findings of the study suggest that in order to be more effective, USFS public involvement programs should be more responsive to public concerns and conducted in adherence to principles of collaborative planning.

  17. Life Planning Resource Guide. A Resource for Teaching the Life Planning Core Course Area of Ohio's Work and Family Life Program.

    Science.gov (United States)

    Kister, Joanna; And Others

    This guide is designed to assist vocational home economics teachers in implementing the life planning course that is one of the six core course areas of Ohio's Work and Family Life program. Included in the guide are an introduction providing an overview of the practical problems proposed in the life planning core course area, four process modules,…

  18. Nutrition and Wellness Resource Guide. A Resource for Teaching the Nutrition and Wellness Core Course Area of Ohio's Work and Family Life Program.

    Science.gov (United States)

    Kister, Joanna; And Others

    This guide is designed to assist vocational home economics teachers in implementing the nutrition and wellness course that is one of the six core course areas of Ohio's Work and Family Life program. Included in the guide are an introduction providing an overview of the practical problems proposed in the nutrition and wellness core course area,…

  19. Implementation of equity in resource allocation for regional earthquake risk mitigation using two-stage stochastic programming.

    Science.gov (United States)

    Zolfaghari, Mohammad R; Peyghaleh, Elnaz

    2015-03-01

    This article presents a new methodology to implement the concept of equity in regional earthquake risk mitigation programs using an optimization framework. It presents a framework that could be used by decisionmakers (government and authorities) to structure budget allocation strategy toward different seismic risk mitigation measures, i.e., structural retrofitting for different building structural types in different locations and planning horizons. A two-stage stochastic model is developed here to seek optimal mitigation measures based on minimizing mitigation expenditures, reconstruction expenditures, and especially large losses in highly seismically active countries. To consider fairness in the distribution of financial resources among different groups of people, the equity concept is incorporated using constraints in model formulation. These constraints limit inequity to the user-defined level to achieve the equity-efficiency tradeoff in the decision-making process. To present practical application of the proposed model, it is applied to a pilot area in Tehran, the capital city of Iran. Building stocks, structural vulnerability functions, and regional seismic hazard characteristics are incorporated to compile a probabilistic seismic risk model for the pilot area. Results illustrate the variation of mitigation expenditures by location and structural type for buildings. These expenditures are sensitive to the amount of available budget and equity consideration for the constant risk aversion. Most significantly, equity is more easily achieved if the budget is unlimited. Conversely, increasing equity where the budget is limited decreases the efficiency. The risk-return tradeoff, equity-reconstruction expenditures tradeoff, and variation of per-capita expected earthquake loss in different income classes are also presented. © 2015 Society for Risk Analysis.

  20. International Resource Management.

    Science.gov (United States)

    Schabel, H. G.

    The International Resource Management program enables undergraduate students of the University of Wisconsin, Stevens Point, College of Natural Resources to complete an academic minor in International Resource Management. The program attempts to alert students and faculty to global environmental issues and their interconnectedness with a variety of…

  1. Wood fuel technologies and group-oriented Timber Stand Improvement Program: model for waste wood utilization and resource renewal

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    Progress is reported on the following: educating and assisting landowners in the most efficient and profitable use of wood resources; developing local timber resources as energy alternatives by representing collective interests to Consumers Power, the woodchip industry, firewood retailers, country residents, and woodlot owners; and providing public information on the economics and methods of wood heat as a supplemental energy source. (MHR)

  2. Institutional Boundaries and Common-Pool Resource Management: A Comparative Analysis of Water Management Programs in California

    Science.gov (United States)

    Heikkila, Tanya

    2004-01-01

    Policymakers and academics often identify institutional boundaries as one of the factors that shape the capacity of jurisdictions to manage natural resources such as water, forests, and scenic lands. This article examines two key bodies of literature--common-pool resource management theory and local public economy theory--to explain how the…

  3. Air quality analysis and related risk assessment for the Bonneville Power Administration's Resource Program Environmental Impact Statement

    Energy Technology Data Exchange (ETDEWEB)

    Glantz, C S; Burk, K W; Driver, C J; Liljegren, J C; Neitzel, D A; Schwartz, M N; Dana, M T; Laws, G L; Mahoney, L A; Rhoads, K

    1992-04-01

    The Bonneville Power Administration (BPA) is considering 12 different alternatives for acquiring energy resources over the next 20 years. Each of the alternatives utilizes a full range of energy resources (e.g., coal, cogeneration, conservation, and nuclear); however, individual alternatives place greater emphases on different types of power-producing resources and employ different timetables for implementing these resources. The environmental impacts that would result from the implementation of each alternative and the economic valuations of these impacts, will be an important consideration in the alternative selection process. In this report we discuss the methods used to estimate environmental impacts from the resource alternatives. We focus on pollutant emissions rates, ground-level air concentrations of basic criteria pollutants, the acidity of rain, particulate deposition, ozone concentrations, visibility attenuation, global warming, human health effects, agricultural and forest impacts, and wildlife impacts. For this study, pollutant emission rates are computed by processing BPA data on power production and associated pollutant emissions. The assessment of human health effects from ozone indicated little variation between the resource alternatives. Impacts on plants, crops, and wildlife populations from power plant emissions are projected to be minimal for all resource alternatives.

  4. Evaluation and Proposed Refinement of the Sampling Design for the Long Term Resource Monitoring Program's Fish Component

    National Research Council Canada - National Science Library

    Ickes, Brian

    2002-01-01

    ... if the sampling design adequately addresses program goals and objectives. Periodic evaluations also permit assessment of a program's ability to provide adequate and useful information for changing management and science needs...

  5. Hydrography - Water Resources

    Data.gov (United States)

    NSGIC Education | GIS Inventory — A Water Resource is a DEP primary facility type related to the Water Use Planning Program. The sub-facility types related to Water Resources that are included are:...

  6. Effects of a Structured Resource-Based Web Issue-Quest Approach on Students' Learning Performances in Computer Programming Courses

    Science.gov (United States)

    Hsu, Ting-Chia; Hwang, Gwo-Jen

    2017-01-01

    Programming concepts are important and challenging to novices who are beginning to study computer programming skills. In addition to the textbook content, students usually learn the concepts of programming from the web; however, it could be difficult for novice learners to effectively derive helpful information from such non-structured open…

  7. Report of the Inter-Society Commission for Heart Disease Resources. Optimal resources for cardiac surgery guidelines for program planning and evaluation.

    Science.gov (United States)

    1975-11-01

    This updated and expanded planning guideline describes the optimal environment in which cardiac surgery can be performed effectively and safely and suggests criteria for evaluating existing facilities and for long-range hospital planning. The status of cardiac surgery is reviewed and measures are provided for assessing a hospital's ability to support a cardiac surgical service. Recommendations are given for appropriate case loads, administrative arrangements, and professional staff qualifications and relationships. The emerging role of the nurse is considered and requirements are enumerated for allied clinical supporting services. Special criteria are provided for pediatric cardiac surgical units and detailed specifications are given for the hospital's physical plant and equiptment including a protocol for checking the electrical safety of surgical suites. A data base is suggested for taking regular inventory of community cardiac surgical programs.

  8. 78 FR 77155 - Grant Program To Assess, Evaluate, and Promote Development of Tribal Energy and Mineral Resources

    Science.gov (United States)

    2013-12-20

    ... on tribal energy and mineral resources, including digital land grids, geographic information system... by electronic funds transfer (through the Treasury Fedline Payment System (FEDLINE)). The recipient... and Mineral Development Funding D. Submission of Application in Digital Format E. Application...

  9. Digital Cadavers: Online 2D Learning Resources Enhance Student Learning in Practical Head and Neck Anatomy within Dental Programs

    Directory of Open Access Journals (Sweden)

    Mahmoud M. Bakr

    2016-01-01

    Full Text Available Head and neck anatomy provides core concepts within preclinical dental curricula. Increased student numbers, reduced curricula time, and restricted access to laboratory-based human resources have increased technology enhanced learning approaches to support student learning. Potential advantages include cost-effectiveness, off-campus access, and self-directed review or mastery opportunities for students. This study investigated successful student learning within a first-year head and neck anatomy course at the School of Dentistry and Oral Health, Griffith University, Australia, taught by the same teaching team, between 2010 and 2015. Student learning success was compared, for cohorts before and after implementation of a supplementary, purpose-designed online digital library and quiz bank. Success of these online resources was confirmed using overall students’ performance within the course assessment tasks and Student Evaluation of Course surveys and online access data. Engagement with these supplementary 2D online resources, targeted at improving laboratory study, was positively evaluated by students (mean 85% and significantly increased their laboratory grades (mean difference 6%, P<0.027, despite being assessed using cadaveric resources. Written assessments in final exams were not significantly improved. Expanded use of supplementary online resources is planned to support student learning and success in head and neck anatomy, given the success of this intervention.

  10. Coal conversion and biomass conversion: Volume 1: Final report on USAID (Agency for International Development)/GOI (Government of India) Alternate Energy Resources and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Kulkarni, A.; Saluja, J.

    1987-06-30

    The United States Agency for International Development (AID), in joint collaboration with the Government of India (GOI), supported a research and development program in Alternate Energy Resources during the period March 1983 to June 1987. The primary emphasis of this program was to develop new and advanced coal and biomass conversion technologies for the efficient utilization of coal and biomass feedstocks in India. This final ''summary'' report is divided into two volumes. This Report, Volume I, covers the program overview and coal projects and Volume II summarizes the accomplishments of the biomass projects. The six projects selected in the area of coal were: Evaluation of the Freeboard Performance in a Fluidized-Bed Combustor; Scale-up of AFBC boilers; Rheology, Stability and Combustion of Coal-Water Slurries; Beneficiation of Fine Coal in Dense Medium Cyclones; Hot Gas Cleanup and Separation; and Cold Gas Cleanup and Separation.

  11. State-coupled low-temperature geothermal-resource assessment program, Fiscal Year 1979. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    Icerman, L.; Starkey, A.; Trentman, N. (eds.)

    1980-10-01

    The results of low-temperature geothermal energy resource assessment efforts in New Mexico during the period from 1 October 1978 to 30 June 1980 are summarized. The results of the efforts to extend the inventory of geothermal energy resources in New Mexico to low-temperature geothermal reservoirs with the potential for direct heating applications are given. These efforts focused on compiling basic geothermal data and new hydrology and temperature gradient data throughout New Mexico in a format suitable for direct transfer to the US Geological Survey and the National Oceanic and Atmospheric Administration for inclusion in the GEOTHERM data file and for preparation of New Mexico low-temperature geothermal resources maps. The results of geothermal reservoir confirmation studies are presented. (MHR)

  12. Introduction to a Special Issue of the Journal of Immunological Methods: Building global resource programs to support HIV/AIDS clinical trial studies.

    Science.gov (United States)

    Sanchez, Ana M; Denny, Thomas N; O'Gorman, Maurice

    2014-07-01

    This Special Issue of the Journal of Immunological Methods includes 16 manuscripts describing quality assurance activities related to virologic and immunologic monitoring of six global laboratory resource programs that support international HIV/AIDS clinical trial studies: Collaboration for AIDS Vaccine Discovery (CAVD); Center for HIV/AIDS Vaccine Immunology (CHAVI); External Quality Assurance Program Oversight Laboratory (EQAPOL); HIV Vaccine Trial Network (HVTN); International AIDS Vaccine Initiative (IAVI); and Immunology Quality Assessment (IQA). The reports from these programs address the many components required to develop comprehensive quality control activities and subsequent quality assurance programs for immune monitoring in global clinical trials including: all aspects of processing, storing, and quality assessment of PBMC preparations used ubiquitously in HIV clinical trials, the development and optimization of assays for CD8 HIV responses and HIV neutralization, a comprehensive global HIV virus repository, and reports on the development and execution of novel external proficiency testing programs for immunophenotyping, intracellular cytokine staining, ELISPOT and luminex based cytokine measurements. In addition, there are articles describing the implementation of Good Clinical Laboratory Practices (GCLP) in a large quality assurance laboratory, the development of statistical methods specific for external proficiency testing assessment, a discussion on the ability to set objective thresholds for measuring rare events by flow cytometry, and finally, a manuscript which addresses a framework for the structured reporting of T cell immune function based assays. It is anticipated that this series of manuscripts covering a wide range of quality assurance activities associated with the conduct of global clinical trials will provide a resource for individuals and programs involved in improving the harmonization, standardization, accuracy, and sensitivity of

  13. A case study review of technical and technology issues for transition of a utility load management program to provide system reliability resources in restructured electricity markets

    Energy Technology Data Exchange (ETDEWEB)

    Weller, G.H.

    2001-07-15

    Utility load management programs--including direct load control and interruptible load programs--were employed by utilities in the past as system reliability resources. With electricity industry restructuring, the context for these programs has changed; the market that was once controlled by vertically integrated utilities has become competitive, raising the question: can existing load management programs be modified so that they can effectively participate in competitive energy markets? In the short run, modified and/or improved operation of load management programs may be the most effective form of demand-side response available to the electricity system today. However, in light of recent technological advances in metering, communication, and load control, utility load management programs must be carefully reviewed in order to determine appropriate investments to support this transition. This report investigates the feasibility of and options for modifying an existing utility load management system so that it might provide reliability services (i.e. ancillary services) in the competitive markets that have resulted from electricity industry restructuring. The report is a case study of Southern California Edison's (SCE) load management programs. SCE was chosen because it operates one of the largest load management programs in the country and it operates them within a competitive wholesale electricity market. The report describes a wide range of existing and soon-to-be-available communication, control, and metering technologies that could be used to facilitate the evolution of SCE's load management programs and systems to provision of reliability services. The fundamental finding of this report is that, with modifications, SCE's load management infrastructure could be transitioned to provide critical ancillary services in competitive electricity markets, employing currently or soon-to-be available load control technologies.

  14. PROGRAM TECHNICAL SYSTEM OF PROVIDING OF SECURITY OF THE INFORMATIVE RESOURCES FOR ON THE CIRCLES OF ELECTRIC POWER SUPPLY

    Directory of Open Access Journals (Sweden)

    V.M. Bakiko

    2010-08-01

    Full Text Available The model of anti-interference protective filter with due account taken of stray parameters of elements is developed. The algorithm of functioning of anti-interference protective filter with integrated system management, which forms the new class of intellectual devices of security of informative resources on the circles of power supply, is offered. The analysis of possibilities of dynamic magnetic biasing of direct current of pericardium of throttle with the use of latitudinal impulsive modulation is experimentally conducted. The efficiency of hardware-software complex of security of informative resources is explored.

  15. Getting the Right Mix: Sustainability and Resource Development Strategies in Out-of-School Time Youth Arts Programs in Massachusetts

    Science.gov (United States)

    Proffitt, Christine

    2010-01-01

    High-quality youth arts programs that take place outside the formal education system play a vital role in supporting the developmental needs and well-being of today's youth, particularly youth at risk of negative outcomes. Out-of-school time (OST) youth arts programs provide opportunities for youth to learn about themselves and their world while…

  16. Resources for Industry

    Science.gov (United States)

    NCI develops and commercializes novel technologies and products to prevent, diagnose, and treat cancer through its Small Business Innovation Research and Small Business Technology Transfer programs. Find links to these programs and resources.

  17. National uranium resource evaluation program: hydrogeochemical and stream sediment reconnaissance basic data for Ely quadrangle, Nevada; Utah

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-15

    Field and laboratory data are presented for 1937 sediment samples from the Ely Quadrangle, Nevada; Utah. The samples were collected by Savannah River Laboratory; laboratory analysis and data reporting were performed by the Uranium Resource Evaluation Project at Oak Ridge, Tennessee.

  18. 76 FR 78684 - Grant Program To Assess, Evaluate and Promote Development of Tribal Energy and Mineral Resources

    Science.gov (United States)

    2011-12-19

    ... geothermal). Mineral resources include industrial minerals (e.g., sand, gravel), precious minerals (e.g... seismic data), geology and engineering data, are all stored at DEMD's offices. All of these data sets can... produces near the reservation, discuss the possible extension or trend of the deposit onto the reservation...

  19. Serving the Needs of Separating and Divorcing Families: A National Survey of Extension Parenting Education Programs and Resources

    Science.gov (United States)

    Mulroy, Maureen T.; Riffe, Jane; Brandon, Denise; Lo, Yi-An; Vaidyanath, Harini

    2013-01-01

    An online survey was developed to map Extension's presence in divorce education initiatives and to catalogue the amount, type, and availability of resources that each state has dedicated to meeting the needs of this parent audience. Requests for participation were sent to members on the National Extension Human Service listserv and resulted…

  20. An Assessment of Agriculture and Natural Resource Extension Program Needs on American Indian Reservations in Idaho, Nevada, Oregon, and Washington

    Science.gov (United States)

    Singletary, Loretta; Emm, Staci; Hill, George

    2011-01-01

    This article summarizes the results of a needs assessment involving American Indians and outreach professionals on reservations in Idaho, Nevada, Oregon and Washington. The survey featured 36 questions about agricultural and natural resource issues that may pose challenges on reservation lands. A comparison between reservation residents and…

  1. Penny wise, pound foolish: an assessment of Canadian Hemophilia/inherited bleeding disorder comprehensive care program services and resources.

    Science.gov (United States)

    Page, D; Crymble, S; Lawday, K; Long, M; Stoffman, J; Waterhouse, L; Wilton, P

    2016-07-01

    A network of 25 haemophilia/inherited bleeding disorder comprehensive care centres was established in Canada in the 1970s and 1980s. In 2007, standards of care, focused on the structural and resource requirements necessary to effectively provide optimal care, were adopted. Assess how human and physical resources affect centres' capacity to attain standards of care. The Canadian Hemophilia Society (CHS), with the support of the Association of Hemophilia Clinic Directors of Canada (AHCDC), undertook the assessment. Health care providers were interviewed in person by lay CHS volunteers and staff. A comprehensive patient satisfaction survey was mailed to a representative cross-section of patients/caregivers. The CHS observed that, despite competent and dedicated staff, many of the programmes are experiencing serious resource deficiencies. Twenty-three of the 25 programmes lack resources in one or more of the following disciplines: haematology, nursing, physiotherapy, social work and clerical/data entry. In nine of the 25 programmes, no resources are allocated to certain core disciplines, notably physiotherapy and social work. Key standards of care, including regular health assessments and close monitoring of home infusion with factor concentrates, are not always respected. Nevertheless, a high level of satisfaction was observed among patients and their caregivers. The study also discovered that clotting factor concentrates constitute 90-95% of the total cost of care while all other aspects of care delivery represent only 5-10%. Under-funding of programmes and suboptimal monitoring of valuable clotting factor concentrate utilization and reporting are both 'penny-wise' and 'pound-foolish'. A formal accreditation process is needed. © 2016 John Wiley & Sons Ltd.

  2. Early infant HIV-1 diagnosis programs in resource-limited settings: opportunities for improved outcomes and more cost-effective interventions

    Directory of Open Access Journals (Sweden)

    Freedberg Kenneth A

    2011-05-01

    Full Text Available Abstract Early infant diagnosis (EID of HIV-1 infection confers substantial benefits to HIV-infected and HIV-uninfected infants, to their families, and to programs providing prevention of mother-to-child transmission (PMTCT services, but has been challenging to implement in resource-limited settings. In order to correctly inform parents/caregivers of infant infection status and link HIV-infected infants to care and treatment, a 'cascade' of events must successfully occur. A frequently cited barrier to expansion of EID programs is the cost of the required laboratory assays. However, substantial implementation barriers, as well as personnel and infrastructure requirements, exist at each step in the cascade. In this update, we review challenges to uptake at each step in the EID cascade, highlighting that even with the highest reported levels of uptake, nearly half of HIV-infected infants may not complete the cascade successfully. We next synthesize the available literature about the costs and cost effectiveness of EID programs; identify areas for future research; and place these findings within the context of the benefits and challenges to EID implementation in resource-limited settings.

  3. U.S. Geological Survey program of offshore resource and geoenvironmental studies, Atlantic-Gulf of Mexico region, from September 1, 1976, to December 31, 1978

    Science.gov (United States)

    Folger, David W.; Needell, Sally W.

    1983-01-01

    Mineral and energy resources of the continental margins of the United States arc important to the Nation's commodity independence and to its balance of payments. These resources are being studied along the continental margins of the Atlantic Ocean and the Gulf of Mexico in keeping with the mission of the U.S. Geological Survey to survey the geologic structures, mineral resources, and products of the national domain.'(Organic Act of 1879). An essential corollary to these resource studies is the study of potential geologic hazards that may be associated with offshore resource exploration and exploitation. In cooperation with the U.S. Bureau of Land Management, the Geological Survey, through its Atlantic-Gulf of Mexico Marine Geology Program, carries out extensive research to evaluate hazards from sediment mobility, shallow gas, and slumping and to acquire information on the distribution and concentration of trace metals and biogenic and petroleum-derived hydrocarbons in sea-floor sediments. All these studies arc providing needed background information, including information on pollutant dispersal, on the nearshore, estuarine, and lacustrine areas that may be near pipeline and nuclear powerplant sites. Users of these data include the Congress, many Federal agencies, the coastal States, private industry, academia, and the concerned public. The results of the regional structural, stratigraphic, and resource studies carried out under the Atlantic-Gulf of Mexico Marine Geology Program have been used by the Geological Survey and the Bureau of Land Management to select areas for future leasing and to aid in the evaluation of tracts nominated for leasing. Resource studies have concentrated mostly on the Atlantic Outer Continental Shelf frontier areas. Geologic detailing of five major basins along the U.S. Atlantic margin, where sediments are as much as 14 km thick, have been revealed by 25,000 km of 24-and 48-channel common-depth-point seismic data, 187,000 km of

  4. The Trust Fund for the Administration of the Forest Development Program, and the Inventory and Monitoring of Jalisco's Natural Resources

    Science.gov (United States)

    Luis Artemio T. Alonso

    2006-01-01

    In 1966 the State Government of Jalisco conducted a review of the state’s forest sector. A new forest agenda resulted from this review, which led to a set of ground breaking actions creating a long term forest development program known as FIPRODEFO (Trust Fund for the Administration of the Forest Development Program of Jalisco). Among the relevant issues, the survey...

  5. Assessing the Sustainability of Small Farmer Natural Resource Management Systems. A Critical Analysis of the MESMIS Program (1995-2010)

    OpenAIRE

    Marta Astier; Luis García-Barrios; Yankuic Galván-Miyoshi; Carlos E. González-Esquivel; Omar R. Masera

    2012-01-01

    Sustainability assessment oriented to improve current systems and practices is urgently needed, particularly in the context of small farmer natural resource management systems (NRMS). Unfortunately, social-ecological systems (SES) theory, sustainability evaluation frameworks, and assessment methods are still foreign not only to farmers but to many researchers, students, NGOs, policy makers/operators, and other interested groups. In this paper we examine the main achievements and challenges of...

  6. A linear programming based method for the resource constrained multi-project scheduling problem with weighted earliness/tardiness costs

    OpenAIRE

    Pamay, Mehmet Berke

    2011-01-01

    This study addresses the Resource Constrained Multi Project Scheduling Problem with Weighted Earliness Tardiness Costs (RCMPSPWET). In multi-project environments, the project portfolio of a company does often change dramatically in time. In this dynamic context, the arrival of a new project requires quoting a due date while keeping the disruptions to the existing plans and schedules to a minimum. The suggested solution method is an adaptation of the well known shifting bottleneck (SB) h...

  7. Online Resources

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Online Resources. Journal of Genetics. Online Resources. Volume 96. 2017 | Online resources. Volume 95. 2016 | Online resources. Volume 94. 2015 | Online resources. Volume 93. 2014 | Online resources. Volume 92. 2013 | Online resources. Volume 91. 2012 | Online resources ...

  8. Resource assessment of low- and moderate-temperature geothermal waters in Calistoga, Napa County, California. Report of the second year, 1979 to 1980 of the US Department of Energy-California State-Coupled Program for reservoir assessment and confirmation

    Energy Technology Data Exchange (ETDEWEB)

    Youngs, L.G.; Bacon, C.F.; Chapman, R.H.; Chase, G.W.; Higgins, C.T.; Majmundar, H.H.; Taylor, G.C.

    1980-11-10

    Statewide assessment studies included updating and completing the USGS GEOTHERM File for California and compiling all data needed for a California Geothermal Resources Map. Site specific assessment studies included a program to assess the geothermal resource at Calistoga, Napa County, California. The Calistoga effort was comprised of a series of studies involving different disciplines, including geologic, hydrologic, geochemical and geophysical studies.

  9. Evaluations of training programs to improve human resource capacity for HIV, malaria, and TB control: a systematic scoping review of methods applied and outcomes assessed.

    Science.gov (United States)

    Wu, Shishi; Roychowdhury, Imara; Khan, Mishal

    2017-01-01

    Owing to the global health workforce crisis, more funding has been invested in strengthening human resources for health, particularly for HIV, tuberculosis, and malaria control; however, little is known about how these investments in training are evaluated. This paper examines how frequently HIV, malaria, and TB healthcare provider training programs have been scientifically evaluated, synthesizes information on the methods and outcome indicators used, and identifies evidence gaps for future evaluations to address. We conducted a systematic scoping review of publications evaluating postgraduate training programs, including in-service training programs, for HIV, tuberculosis, and malaria healthcare providers between 2000 and 2016. Using broad inclusion criteria, we searched three electronic databases and additional gray literature sources. After independent screening by two authors, data about the year, location, methodology, and outcomes assessed was extracted from eligible training program evaluation studies. Training outcomes evaluated were categorized into four levels (reaction, learning, behavior, and results) based on the Kirkpatrick model. Of 1473 unique publications identified, 87 were eligible for inclusion in the analysis. The number of published articles increased after 2006, with most (n = 57, 66%) conducted in African countries. The majority of training evaluations (n = 44, 51%) were based on HIV with fewer studies focused on malaria (n = 28, 32%) and TB (n = 23, 26%) related training. We found that quantitative survey of trainees was the most commonly used evaluation method (n = 29, 33%) and the most commonly assessed outcomes were knowledge acquisition (learning) of trainees (n = 44, 51%) and organizational impacts of the training programs (38, 44%). Behavior change and trainees' reaction to the training were evaluated less frequently and using less robust methods; costs of training were also rarely assessed. Our study found

  10. A Lesson in Carefully Managing Resources: A Case Study from an Evaluation of a Music Education Program

    Science.gov (United States)

    Hobson, Kristin A.; Burkhardt, Jason T.

    2012-01-01

    Background: A music education program with a goal of enhancing cognitive development of preschool-aged children enrolled in local preschools is evaluated by The Evaluation Center at Western Michigan University. The budget for the evaluation was small, and therefore presented several challenges to the evaluation team. Purpose: Through a case study…

  11. Developing a Contemporary Dairy Foods Extension Program: A Training and Technical Resource Needs Assessment of Pennsylvania Dairy Foods Processors

    Science.gov (United States)

    Syrko, Joseph; Kaylegian, Kerry E.

    2015-01-01

    Growth in the dairy industry and the passage of the Food Safety Modernization Act have renewed interest in dairy foods processing extension positions. A needs assessment survey was sent to Pennsylvania dairy processors and raw milk providers to guide priorities for a dairy foods extension program. The successful development and delivery of…

  12. Multilingual Pedagogies and Pre-Service Teachers: Implementing "Language as a Resource" Orientations in Teacher Education Programs

    Science.gov (United States)

    Catalano, Theresa; Hamann, Edmund T.

    2016-01-01

    While Ruiz's (1984) influential work on language orientations has substantively influenced how we study and talk about language planning, few teacher education programs today actually embed his framework in the praxis of preparing pre-service and practicing teachers. Hence, the primary purpose of this article is to demonstrate new understandings…

  13. 45 CFR 2520.40 - Under what circumstances may AmeriCorps members in my program raise resources?

    Science.gov (United States)

    2010-10-01

    ... community and is delivered, in whole or in part, through the members of a community-based organization; (5) Seeking donations from alumni of the program for specific service projects being performed by current members. (c) AmeriCorps members may not: (1) Raise funds for living allowances or for an organization's...

  14. The Current State of Early Childhood Education Programs: How Early Childhood Center Directors Manage Their Human Resources

    Science.gov (United States)

    Arend, Lauren E.

    2010-01-01

    Purpose: Research in the field of early childhood education (ECE) demonstrated the association between skilled directors and high quality programs. Still, most state licensing requirements do not delineate the requisite knowledge or experience necessary to be an effective director. Many ECE directors advance to their position directly from the…

  15. Salinity. Grade 5 Science Language Usage. Maryland School Maryland School Performance Assessment Program (MSPAP): Resource Library. Public Release Task.

    Science.gov (United States)

    Maryland State Dept. of Education. Baltimore. Div. of Planning, Results and Information Management.

    One component of the Maryland School Performance Assessment; Program (MSPAP) is the state's performance-based assessments, criterion-referenced tests that require students to apply what they know and can do to solve problems and display other higher-order thinking skills. This document helps parents, teachers, students, and other citizens…

  16. Evaluating the Impact of a Summer Dropout Prevention Program for Incoming Freshmen Attending an Under-Resourced High School

    Science.gov (United States)

    Vera, Elizabeth; Shriberg, David; Alves, Alison; de Oca, Jessie Montes; Reker, Kassandra; Roche, Meghan; Salgado, Manuel; Stegmaier, Jessica; Viellieu, Lindsay; Karahalios, Vicky; Knoll, Michael; Adams, Kristen; Diaz, Yahaira; Rau, Ellen

    2016-01-01

    Low high school completion rates are an ongoing challenge for educators. This study provides the results of an evaluation of a ninth-grade summer transition program offered at a large public school with a high freshman dropout rate. The evaluation consisted of preprogram and postprogram surveys and interviews with 64 incoming freshman…

  17. Human Resource Management System

    OpenAIRE

    Navaz, A. S. Syed; Fiaz, A. S. Syed; Prabhadevi, C.; Sangeetha, V.; Gopalakrishnan, S.

    2013-01-01

    The paper titled HUMAN RESOURCE MANAGEMENT SYSTEM is basically concerned with managing the Administrator of HUMAN RESOURCE Department in a company. A Human Resource Management System, refers to the systems and processes at the intersection between human resource management and information technology. It merges HRM as a discipline and in particular its basic HR activities and processes with the information technology field, whereas the programming of data processing systems evolved into standa...

  18. Nursing intensive care skills training: a nurse led, short, structured, and practical training program, developed and tested in a resource-limited setting.

    Science.gov (United States)

    De Silva, A Pubudu; Stephens, Tim; Welch, John; Sigera, Chathurani; De Alwis, Sunil; Athapattu, Priyantha; Dharmagunawardene, Dilantha; Olupeliyawa, Asela; de Abrew, Ashwini; Peiris, Lalitha; Siriwardana, Somalatha; Karunathilake, Indika; Dondorp, Arjen; Haniffa, Rashan

    2015-04-01

    To assess the impact of a nurse-led, short, structured training program for intensive care unit (ICU) nurses in a resource-limited setting. A training program using a structured approach to patient assessment and management for ICU nurses was designed and delivered by local nurse tutors in partnership with overseas nurse trainers. The impact of the course was assessed using the following: pre-course and post-course self-assessment, a pre-course and post-course Multiple Choice Questionnaire (MCQ), a post-course Objective Structured Clinical Assessment station, 2 post-course Short Oral Exam (SOE) stations, and post-course feedback questionnaires. In total, 117 ICU nurses were trained. Post-MCQ scores were significantly higher when compared with pre-MCQ (P Nursing Intensive Care Skills Training was highly rated by participants and was effective in improving the knowledge of the participants. This sustainable short course model may be adaptable to other resource-limited settings. Copyright © 2014 Elsevier Inc. All rights reserved.

  19. Self-reported information needs of anesthesia residency applicants and analysis of applicant-related web sites resources at 131 United States training programs.

    Science.gov (United States)

    Chu, Larry F; Young, Chelsea A; Zamora, Abby K; Lowe, Derek; Hoang, Dan B; Pearl, Ronald G; Macario, Alex

    2011-02-01

    Despite the use of web-based information resources by both anesthesia departments and applicants, little research has been done to assess these resources and determine whether they are meeting applicant needs. Evidence is needed to guide anesthesia informatics research in developing high-quality anesthesia residency program Web sites (ARPWs). We used an anonymous web-based program (SurveyMonkey, Portland, OR) to distribute a survey investigating the information needs and perceived usefulness of ARPWs to all 572 Stanford anesthesia residency program applicants. A quantitative scoring system was then created to assess the quality of ARPWs in meeting the information needs of these applicants. Two researchers independently analyzed all 131 ARPWs in the United States to determine whether the ARPWs met the needs of applicants based on the scoring system. Finally, a qualitative assessment of the overall user experience of ARPWs was developed to account for the subjective elements of the Web site's presentation. Ninety-eight percent of respondents reported having used ARPWs during the application process. Fifty-six percent reported first visiting the Stanford ARPW when deciding whether to apply to Stanford's anesthesia residency program. Multimedia and Web 2.0 technologies were "very" or "most" useful in "learning intangible aspects of a program, like how happy people are" (42% multimedia and Web 2.0 versus 14% text and photos). ARPWs, on average, contained only 46% of the content items identified as important by applicants. The average (SD) quality scores among all ARPWs was 2.06 (0.59) of 4.0 maximum points. The mean overall qualitative score for all 131 ARPWs was 4.97 (1.92) of 10 points. Only 2% of applicants indicated that the majority (75%-100%) of Web sites they visited provided a complete experience. Anesthesia residency applicants rely heavily on ARPWs to research programs, prepare for interviews, and formulate a rank list. Anesthesia departments can improve their

  20. Hydrogeochemical and stream-sediment reconnaissance, orientation study, Ouachita Mountain area, Arkansas. National Uranium Resource Evaluation Program

    Energy Technology Data Exchange (ETDEWEB)

    Steele, K. F.

    1982-08-01

    A hydrogeochemical ground water orientation study was conducted in the multi-mineralized area of the Ouachita Mountains, Arkansas in order to evaluate the usefulness of ground water as a sampling medium for uranium exploration in similar areas. Ninety-three springs and nine wells were sampled in Clark, Garland, Hot Springs, Howard, Montgomery, Pike, Polk, and Sevier Counties. Manganese, barite, celestite, cinnabar, stibnite, copper, lead, and zinc are present. The following parameters were determined: pH, conductivity, alkalinity, U, Br, Cl, F, He, Mn, Na, V, Al, Dy, NO/sub 3/, NH/sub 3/, SO/sub 4/, and PO/sub 4/. The minerals appear to significantly affect the chemistry of the ground water. This report is issued in draft form, without detailed technical and copy editing. This was done to make the report available to the public before the end of the National Uranium Resource Evaluation.

  1. Annual Report: EPAct Complementary Program's Ultra-Deepwater R&D Portfolio and Unconventional Resources R&D Portfolio (30 September 2012)

    Energy Technology Data Exchange (ETDEWEB)

    none,; Rose, Kelly [NETL; Hakala, Alexandra [NETL; Guthrie, George [NETL

    2012-09-30

    This report summarizes FY13 research activities performed by the National Energy Technology Laboratory (NETL), Office of Research and Development (ORD), along with its partners in the Regional University Alliance (RUA) to fulfill research needs under the Energy Policy Act of 2005 (EPAct) Section 999's Complementary Program. Title IX, Subtitle J, Section 999A(d) of EPAct 2005 authorizes $50 million per year of federal oil and gas royalties, rents and bonus payments for an oil and natural gas research and development effort, the Ultra-Deepwater and Unconventional Natural Gas and Other Petroleum Resources Research Program. Section 999 further prescribes four program elements for the effort, one of which is the Complementary Research Program that is to be performed by NETL. This document lays out the plan for the research portfolio for the Complementary Research Program, with an emphasis on the 2013 funding. The Complementary Program consists of two research portfolios focused on domestic resources: (1) the Deepwater and Ultra-Deepwater Portfolio (UDW) (focused on hydrocarbons in reservoirs in extreme environments) and (2) the Unconventional Resources Portfolio (UCR) (focused on hydrocarbons in shale reservoirs). These two portfolios address the science base that enables these domestic resources to be produced responsibly, informing both regulators and operators. NETL is relying on a core Department of Energy-National Energy Technology Laboratory (DOE-NETL) competency in engineered-natural systems to develop this science base, allowing leveraging of decades of investment. NETL's Complementary Research Program research portfolios support the development of unbiased research and information for policymakers and the public, performing rapid predictions of possible outcomes associated with unexpected events, and carrying out quantitative assessments for energy policy stakeholders that accurately integrate the risks of safety and environmental impacts. The

  2. Pharmaceuticals, hormones, personal-care products, and other organic wastewater contaminants in water resources: Recent research activities of the U.S. Geological Survey's toxic substances hydrology program

    Science.gov (United States)

    Focazio, Michael J.; Kolpin, Dana W.; Buxton, Herbert T.

    2003-01-01

    Recent decades have brought increasing concerns for potential contamination of water resources that could inadvertently result during production, use, and disposal of the numerous chemicals offering improvements in industry, agriculture, medical treatment, and even common household products. Increasing knowledge of the environmental occurrence or toxicological behavior of these contaminants from various studies in Europe, United States, and elsewhere has resulted in increased concern for potential adverse environmental and human health effects (Daughton and Ternes, 1999). Ecologists and public health experts often have incomplete understandings of the toxicological significance of many of these contaminants, particularly long-term, low-level exposure and when they occur in mixtures with other contaminants (Daughton and Ternes, 1999; Kümmerer, 2001). In addition, these ‘emerging contaminants’ are not typically monitored or assessed in ambient water resources. The need to understand the processes controlling the transport and fate of these contaminants in the environment, and the lack of knowledge of the significance of long-term exposures have increased the need to study environmental occurrence down to trace (nanogram per liter) levels. Furthermore, the possibility that mixtures of environmental contaminants may interact synergistically or antagonistically has increased the need to characterize the types of mixtures that are found in our waters. The U.S. Geological Survey’s Toxic Substances Hydrology Program (Toxics Program) is developing information and tools on emerging water-quality issues that will be used to design and improve water-quality monitoring and assessment programs of the USGS and others, and for proactive decision-making by industry, regulators, the research community, and the public (http://toxics.usgs.gov/regional/emc.html). This research on emerging water-quality issues includes a combination of laboratory work to develop new analytical

  3. Fostering K-12 Inquiry-based Lesson Development on Regional Water Resource Issues in Los Angeles Urban Schools through the NSF UCLA SEE-LA GK-12 program

    Science.gov (United States)

    Hogue, T. S.; Burke, M. P.; Thulsirag, V.; Daniel, J.; Moldwin, M.; Nonacs, P.

    2010-12-01

    A National Science Foundation Graduate Teaching Fellows in K- 12 Education program at UCLA (SEE-LA; http://measure.igpp.ucla.edu/GK12-SEE-LA/ ) partners UCLA faculty and graduate students (fellows) with urban middle and high school science teachers and their students to foster programs of science and engineering exploration that bring the environment of Los Angeles into the classroom. UCLA graduate fellows serve as scientists-in-residence at four partner schools to integrate inquiry-based science lessons, facilitate advancements in science content teaching, and ultimately, to improve their own science communication skills. As part of their fellowship, graduate students are required to develop inquiry-based lessons in their partner classroom. During the first two years of the project, the SEE-LA fellows have developed a range of inquiry-based activities, from invertebrate observations in an urban stream system, to water and home energy consumption surveys, to a school biodiversity investigation, to a school-wide alternative energy fair, to engineering the cleanup of environmental disasters, such as the recent oil spill in the Gulf of Mexico. Several of the current fellows have dissertation research in water resource related fields and are specifically integrating lessons specific to their research into their partner classrooms, including urban stream water quality, post-fire watershed behavior, beach water quality assessment and E. coli source tracking. This presentation will provide an overview of goals of the SEE-LA GK-12 program, development of inquiry-based water resource lessons and resulting engagement in the partner classrooms. University and local pre-college school partnerships provide an excellent opportunity to support the development of graduate student communication and teaching skills while also contributing significantly to the integration of science education into K-12 curriculum.

  4. Mitigating Negative Externalities Affecting Access and Equity of Education in Low-Resource Countries: A Study Exploring Social Marketing as a Potential Strategy for Planning School Food Programs in Malawi

    Science.gov (United States)

    Magreta-Nyongani, Martha

    2012-01-01

    School feeding programs enhance the efficiency of the education system by improving enrollment, reducing dropouts and increasing perseverance. They also have the potential to reach the poor, directly making them an effective social safety net. In many low-resource countries, school feeding programs are designed to protect children from the effects…

  5. Herpes - resources

    Science.gov (United States)

    Genital herpes - resources; Resources - genital herpes ... following organizations are good resources for information on genital herpes : March of Dimes -- www.marchofdimes.com/pregnancy/complications- ...

  6. Neuroscience in Middle Schools: A Professional Development and Resource Program That Models Inquiry-based Strategies and Engages Teachers in Classroom Implementation

    Science.gov (United States)

    MacNabb, Carrie; Schmitt, Lee; Michlin, Michael; Harris, Ilene; Thomas, Larry; Chittendon, David; Ebner, Timothy J.

    2006-01-01

    The Department of Neuroscience at the University of Minnesota and the Science Museum of Minnesota have developed and implemented a successful program for middle school (grades 5–8) science teachers and their students, called Brain Science on the Move. The overall goals have been to bring neuroscience education to underserved schools, excite students about science, improve their understanding of neuroscience, and foster partnerships between scientists and educators. The program includes BrainU, a teacher professional development institute; Explain Your Brain Assembly and Exhibit Stations, multimedia large-group presentation and hands-on activities designed to stimulate student thinking about the brain; Class Activities, in-depth inquiry-based investigations; and Brain Trunks, materials and resources related to class activities. Formal evaluation of the program indicated that teacher neuroscience knowledge, self-confidence, and use of inquiry-based strategies and neuroscience in their classrooms have increased. Participating teachers increased the time spent teaching neuroscience and devoted more time to “inquiry-based” teaching versus “lecture-based teaching.” Teachers appreciated in-depth discussions of pedagogy and science and opportunities for collegial interactions with world-class researchers. Student interest in the brain and in science increased. Since attending BrainU, participating teachers have reported increased enthusiasm about teaching and have become local neuroscience experts within their school communities. PMID:17012205

  7. Neuroscience in middle schools: a professional development and resource program that models inquiry-based strategies and engages teachers in classroom implementation.

    Science.gov (United States)

    MacNabb, Carrie; Schmitt, Lee; Michlin, Michael; Harris, Ilene; Thomas, Larry; Chittendon, David; Ebner, Timothy J; Dubinsky, Janet M

    2006-01-01

    The Department of Neuroscience at the University of Minnesota and the Science Museum of Minnesota have developed and implemented a successful program for middle school (grades 5-8) science teachers and their students, called Brain Science on the Move. The overall goals have been to bring neuroscience education to underserved schools, excite students about science, improve their understanding of neuroscience, and foster partnerships between scientists and educators. The program includes BrainU, a teacher professional development institute; Explain Your Brain Assembly and Exhibit Stations, multimedia large-group presentation and hands-on activities designed to stimulate student thinking about the brain; Class Activities, in-depth inquiry-based investigations; and Brain Trunks, materials and resources related to class activities. Formal evaluation of the program indicated that teacher neuroscience knowledge, self-confidence, and use of inquiry-based strategies and neuroscience in their classrooms have increased. Participating teachers increased the time spent teaching neuroscience and devoted more time to "inquiry-based" teaching versus "lecture-based teaching." Teachers appreciated in-depth discussions of pedagogy and science and opportunities for collegial interactions with world-class researchers. Student interest in the brain and in science increased. Since attending BrainU, participating teachers have reported increased enthusiasm about teaching and have become local neuroscience experts within their school communities.

  8. Needs assessment of science teachers in secondary schools in Kumasi, Ghana: A basis for in-service education training programs at the Science Resource Centers

    Science.gov (United States)

    Gyamfi, Alexander

    The purpose of this study was twofold. First, it identified the priority needs common to all science teachers in secondary schools in Kumasi, Ghana. Second, it investigated the relationship existing between the identified priority needs and the teacher demographic variables (type of school, teacher qualification, teaching experience, subject discipline, and sex of teacher) to be used as a basis for implementing in-service education training programs at the Science Resource Centers in Kumasi Ghana. An adapted version of the Moore Assessment Profile (MAP) survey instrument and a set of open-ended questions were used to collect data from the science teachers. The researcher handed out one hundred and fifty questionnaire packets, and all one hundred and fifty (100%) were collected within a period of six weeks. The data were analyzed using descriptive statistics, content analysis, and inferential statistics. The descriptive statistics reported the frequency of responses, and it was used to calculate the Need Index (N) of the identified needs of teachers. Sixteen top-priority needs were identified, and the needs were arranged in a hierarchical order according to the magnitude of the Need Index (0.000 ≤ N ≤ 1.000). Content analysis was used to analyze the responses to the open-ended questions. One-way analysis of variance (ANOVA) was used to test the null hypotheses of the study on each of the sixteen identified top-priority needs and the teacher demographic variables. The findings of this study were as follows: (1) The science teachers identified needs related to "more effective use of instructional materials" as a crucial area for in-service training. (2) Host and Satellite schools exhibited significant difference on procuring supplementary science books for students. Subject discipline of teachers exhibited significant differences on utilizing the library and its facilities by students, obtaining information on where to get help on effective science teaching

  9. Subtypes in clinical burnout patients enrolled in an employee rehabilitation program: differences in burnout profiles, depression, and recovery/resources-stress balance.

    Science.gov (United States)

    Bauernhofer, Kathrin; Bassa, Daniela; Canazei, Markus; Jiménez, Paulino; Paechter, Manuela; Papousek, Ilona; Fink, Andreas; Weiss, Elisabeth M

    2018-01-17

    Burnout is generally perceived a unified disorder with homogeneous symptomatology across people (exhaustion, cynicism, and reduced professional efficacy). However, increasing evidence points to intra-individual patterns of burnout symptoms in non-clinical samples such as students, athletes, healthy, and burned-out employees. Different burnout subtypes might therefore exist. Yet, burnout subtypes based on burnout profiles have hardly been explored in clinical patients, and the samples investigated in previous studies were rather heterogeneous including patients with various physical, psychological, and social limitations, symptoms, and disabilities. Therefore, the aim of this study is to explore burnout subtypes based on burnout profiles in clinically diagnosed burnout patients enrolled in an employee rehabilitation program, and to investigate whether the subtypes differ in depression, recovery/resources-stress balance, and sociodemographic characteristics. One hundred three patients (66 women, 37 men) with a clinical burnout diagnosis, who were enrolled in a 5 week employee rehabilitation program in two specialized psychosomatic clinics in Austria, completed a series of questionnaires including the Maslach Burnout Inventory - General Survey (MBI-GS), the Beck Depression Inventory, and the Recovery-Stress-Questionnaire for Work. Cluster analyses with the three MBI-GS subscales as clustering variables were used to identify the burnout subtypes. Subsequent multivariate/univariate analysis of variance and Pearson chi-square tests were performed to investigate differences in depression, recovery/resources-stress balance, and sociodemographic characteristics. Three different burnout subtypes were discovered: the exhausted subtype, the exhausted/cynical subtype, and the burned-out subtype. The burned-out subtype and the exhausted/cynical subtype showed both more severe depression symptoms and a worse recovery/resources-stress balance than the exhausted subtype

  10. The Influence of Community Health Resources on Effectiveness and Sustainability of Community and Lay Health Worker Programs in Lower-Income Countries: A Systematic Review.

    Science.gov (United States)

    de Vries, Daniel H; Pool, Robert

    2017-01-01

    Despite the availability of practical knowledge and effective interventions required to reduce priority health problems in low-income countries, poor and vulnerable populations are often not reached. One possible solution to this problem is the use of Community or Lay Health Workers (CLHWs). So far, however, the development of sustainability in CLHW programs has failed and high attrition rates continue to pose a challenge. We propose that the roles and interests which support community health work should emerge directly from the way in which health is organized at community level. This review explores the evidence available to assess if increased levels of integration of community health resources in CLHW programs indeed lead to higher program effectiveness and sustainability. This review includes peer-reviewed articles which meet three eligibility criteria: 1) specific focus on CLHWs or equivalent; 2) randomized, quasi-randomized, before/after methodology or substantial descriptive assessment; and 3) description of a community or peer intervention health program located in a low- or middle-income country. Literature searches using various article databases led to 2930 hits, of which 359 articles were classified. Of these, 32 articles were chosen for extensive review, complemented by analysis of the results of 15 other review studies. Analysis was conducted using an excel based data extraction form. Because results showed that no quantitative data was published, a descriptive synthesis was conducted. The review protocol was not proactively registered. Findings show minimal inclusion of even basic community level indicators, such as the degree to which the program is a community initiative, community input in the program or training, the background and history of CLHW recruits, and the role of the community in motivation and retention. Results show that of the 32 studies, only one includes one statistical measure of community integration. As a result of this lack of

  11. The Influence of Community Health Resources on Effectiveness and Sustainability of Community and Lay Health Worker Programs in Lower-Income Countries: A Systematic Review.

    Directory of Open Access Journals (Sweden)

    Daniel H de Vries

    Full Text Available Despite the availability of practical knowledge and effective interventions required to reduce priority health problems in low-income countries, poor and vulnerable populations are often not reached. One possible solution to this problem is the use of Community or Lay Health Workers (CLHWs. So far, however, the development of sustainability in CLHW programs has failed and high attrition rates continue to pose a challenge. We propose that the roles and interests which support community health work should emerge directly from the way in which health is organized at community level. This review explores the evidence available to assess if increased levels of integration of community health resources in CLHW programs indeed lead to higher program effectiveness and sustainability.This review includes peer-reviewed articles which meet three eligibility criteria: 1 specific focus on CLHWs or equivalent; 2 randomized, quasi-randomized, before/after methodology or substantial descriptive assessment; and 3 description of a community or peer intervention health program located in a low- or middle-income country. Literature searches using various article databases led to 2930 hits, of which 359 articles were classified. Of these, 32 articles were chosen for extensive review, complemented by analysis of the results of 15 other review studies. Analysis was conducted using an excel based data extraction form. Because results showed that no quantitative data was published, a descriptive synthesis was conducted. The review protocol was not proactively registered. Findings show minimal inclusion of even basic community level indicators, such as the degree to which the program is a community initiative, community input in the program or training, the background and history of CLHW recruits, and the role of the community in motivation and retention. Results show that of the 32 studies, only one includes one statistical measure of community integration. As a result

  12. Assessing the Financial Value of Human Resource Management Programs and Employee Behaviors: A Critical Tool Still Coming of Age

    Directory of Open Access Journals (Sweden)

    Aharon Tziner

    2015-11-01

    Full Text Available This paper highlights investigations into several aspects of the field of economic assessment of human resource management strategies and worker organizational behaviors, both classic and recent. We present the reader with both an historical overview and a review of conceptual and practical developments in this field. It is important to emphasize the influence of the early studies since later financial assessment models were built on the earlier paradigms. The basic thrust of this effort is to encourage the greater employment by managers of quantitative models that allow decision makers to generate all the factors needed to estimate real financial gains and/or losses before any intervention strategy is implemented in the workplace. As indicated, the use of these quantitative models to estimate the net financial gains of using particular intervention strategies or the value of certain types of worker behaviors, can ultimately save companies from making gross tactical errors and, more positively, can assist management in promoting the organization’s long-term economic goals with all the incumbent rewards.

  13. Dental students' HIV/AIDS-related knowledge, attitudes, and intentions: impact of the U.S. Health Resources and Services Administration's community-based dental partnership program.

    Science.gov (United States)

    Hamershock, Rose A; Rajabiun, Serena; Fox, Jane E; Mofidi, Mahyar; Abel, Stephen N; York, Jill A; Kunzel, Carol; Sanogo, Moussa; Mayfield, Theresa G

    2014-08-01

    Access to oral health care for vulnerable populations is one of the concerns addressed by the U.S. Health Resources and Services Administration HIV/AIDS Bureau's Community-Based Dental Partnership Program (CBDPP). The program introduces dental students and residents at several dental schools to care for vulnerable patients through didactic and clinical work in community-based dental settings. This study of the dental students and residents in this program answered three questions: 1) What are their HIV knowledge, attitudes, and behaviors? 2) How has participation in the CBDPP impacted their knowledge, attitudes, and behaviors? 3) Has the intervention affected their work placement decisions and attitudes after graduation, particularly with respect to treating people living with HIV and other underserved populations? A total of 305 first- through fourth-year dental students and first- and second-year residents at five dental schools across the United States completed surveys before and after a community-based rotation and following graduation. Response rates at each of the five schools ranged from 82.4 to 100 percent. The results showed an increase in the participants' knowledge and positive attitudes regarding treatment for patients with HIV and other vulnerable populations post-rotation compared to pre-rotation. Results after graduation found that most respondents were practicing in private settings or in academic institutions as residents but were willing to treat a diverse patient population. These findings support the role of training programs, such as the CBDPP, for expanding the dental workforce to treating vulnerable populations including people living with HIV/AIDS.

  14. RSW-MCFP: A Resource-Oriented Solid Waste Management System for a Mixed Rural-Urban Area through Monte Carlo Simulation-Based Fuzzy Programming

    Directory of Open Access Journals (Sweden)

    P. Li

    2013-01-01

    Full Text Available The growth of global population and economy continually increases the waste volumes and consequently creates challenges to handle and dispose solid wastes. It becomes more challenging in mixed rural-urban areas (i.e., areas of mixed land use for rural and urban purposes where both agricultural waste (e.g., manure and municipal solid waste are generated. The efficiency and confidence of decisions in current management practices significantly rely on the accurate information and subjective judgments, which are usually compromised by uncertainties. This study proposed a resource-oriented solid waste management system for mixed rural-urban areas. The system is featured by a novel Monte Carlo simulation-based fuzzy programming approach. The developed system was tested by a real-world case with consideration of various resource-oriented treatment technologies and the associated uncertainties. The modeling results indicated that the community-based bio-coal and household-based CH4 facilities were necessary and would become predominant in the waste management system. The 95% confidence intervals of waste loadings to the CH4 and bio-coal facilities were 387, 450 and 178, 215 tonne/day (mixed flow, respectively. In general, the developed system has high capability in supporting solid waste management for mixed rural-urban areas in a cost-efficient and sustainable manner under uncertainty.

  15. 7th U.S. / Japan Natural Resources (UJNR) Panel on Earthquake Research: Abstract Volume and Technical Program

    Science.gov (United States)

    Detweiler, Shane T.; Ellsworth, William L.

    2008-01-01

    The U.S. / Japan Natural Resources (UJNR) Panel on Earthquake Research promotes advanced study toward a more fundamental understanding of the earthquake process and hazard estimation. The Panel promotes basic and applied research to improve our understanding of the causes and effects of earthquakes and to facilitate the transmission of research results to those who implement hazard reduction measures on both sides of the Pacific and around the world. Meetings are held every other year, and alternate between countries with short presentation on current research and local field trips being the highlights. The 5th Joint Panel meeting was held at Asilomar, California in October, 2004. The technical sessions featured reports on the September 28, 2004 Parkfield, California earthquake, progress on earthquake early warning and rapid post-event assessment technology, probabilistic earthquake forecasting and the newly discovered phenomenon of nonvolcanic tremor. The Panel visited the epicentral region of the M 6.0 Parkfield earthquake and viewed the surface ruptures along the San Andreas Fault. They also visited the San Andreas Fault Observatory at Depth (SAFOD), which had just completed the first phase of drilling into the fault. The 6th Joint Panel meeting was held in Tokushima, Japan in November, 2006. The meeting included very productive exchanges of information on approaches to systematic observation of earthquake processes. Sixty eight technical papers were presented during the meeting on a wide range of subjects, including interplate earthquakes in subduction zones, slow slip and nonvolcanic tremor, crustal deformation, recent earthquake activity and hazard mapping. Through our discussion, we reaffirmed the benefits of working together to achieve our common goal of reducing earthquake hazard, continued cooperation on issues involving densification of observation networks and the open exchange of data among scientific communities. We also reaffirmed the importance of

  16. Determinants of midterm functional outcomes, wound healing, and resources used in a hospital-based limb preservation program.

    Science.gov (United States)

    Ramanan, Bala; Ahmed, Ayman; Wu, Bian; Causey, Marlin W; Gasper, Warren J; Vartanian, Shant M; Reyzelman, Alexander M; Hiramoto, Jade S; Conte, Michael S

    2017-12-01

    The objective of this study was to assess midterm functional status, wound healing, and in-hospital resource use among a prospective cohort of patients treated in a tertiary hospital, multidisciplinary Center for Limb Preservation. Data were prospectively gathered on all consecutive admissions to the Center for Limb Preservation from July 2013 to October 2014 with follow-up data collection through January 2016. Limbs were staged using the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) threatened limb classification scheme at the time of hospital admission. Patients with nonatherosclerotic vascular disorders, acute limb ischemia, and trauma were excluded. The cohort included 128 patients with 157 threatened limbs; 8 limbs with unstageable disease were excluded. Mean age (±standard deviation [SD]) was 66 (±13) years, and median follow-up duration (interquartile range) was 395 (80-635) days. Fifty percent (n = 64/128) of patients were readmitted at least once, with a readmission rate of 20% within 30 days of the index admission. Mean total number of admissions per patient (±SD) was 1.9 ± 1.2, with mean (±SD) cumulative length of stay (cLOS) of 17.1 (±17.9) days. During follow-up, 25% of limbs required a vascular reintervention, and 45% developed recurrent wounds. There was no difference in the rate of readmission, vascular reintervention, or wound recurrence by initial WIfI stage (P > .05). At the end of the study period, 23 (26%) were alive and nonambulatory; in 20%, functional status was missing. On both univariate and multivariate analysis, end-stage renal disease and prior functional status predicted ability to ambulate independently (P healing. Direct hospital (inpatient) cost per limb saved was significantly higher in stage 4 patients (P healing, or wound recurrence. Patients presenting with limb-threatening conditions require significant inpatient care, have a high frequency of repeated hospitalizations, and are at significant

  17. Water Resources Research program: nearshore currents and water temperatures in southwestern Lake Michigan. Progress report, June--December 1975

    Energy Technology Data Exchange (ETDEWEB)

    Saunders, K.D.; Van Loon, L.S.

    1976-05-01

    Nearshore currents and water temperatures were measured almost continuously from June 23 through December 22, at five moorings in an array centered 4 km offshore of south Chicago. The mooring array was square, each side 1.6 km long. A current-meter mooring was placed at each corner, with one mooring in the center. One Bendix Q-15 current meter and one YSI temperature sensor were fixed to each mooring line. Each meter and associated temperature sensor was placed at middepth; the water depth averaged about 12 m. The following types of graphs are presented for current and wind observations: (1) U, V flow components versus time, (2) specific kinetic energy versus time, (3) flow speeds and directions versus time, (4) composite velocity histograms and associated U, V-component histograms, and (5) progressive-vector diagrams. Also presented are listings of the component programs used to reduce the data. Currents in the region were dominantly shore-parallel. Water temperatures reflected several episodes of upwelling and downwelling. Detailed analyses of the data will be presented in subsequent reports.

  18. Global health leadership training in resource-limited settings: a collaborative approach by academic institutions and local health care programs in Uganda.

    Science.gov (United States)

    Nakanjako, Damalie; Namagala, Elizabeth; Semeere, Aggrey; Kigozi, Joanitor; Sempa, Joseph; Ddamulira, John Bosco; Katamba, Achilles; Biraro, Sam; Naikoba, Sarah; Mashalla, Yohana; Farquhar, Carey; Sewankambo, Nelson

    2015-11-18

    Due to a limited health workforce, many health care providers in Africa must take on health leadership roles with minimal formal training in leadership. Hence, the need to equip health care providers with practical skills required to lead high-impact health care programs. In Uganda, the Afya Bora Global Health Leadership Fellowship is implemented through the Makerere University College of Health Sciences (MakCHS) and her partner institutions. Lessons learned from the program, presented in this paper, may guide development of in-service training opportunities to enhance leadership skills of health workers in resource-limited settings. The Afya Bora Consortium, a consortium of four African and four U.S. academic institutions, offers 1-year global health leadership-training opportunities for nurses and doctors. Applications are received and vetted internationally by members of the consortium institutions in Botswana, Kenya, Tanzania, Uganda, and the USA. Fellows have 3 months of didactic modules and 9 months of mentored field attachment with 80% time dedicated to fellowship activities. Fellows' projects and experiences, documented during weekly mentor-fellow meetings and monthly mentoring team meetings, were compiled and analyzed manually using pre-determined themes to assess the effect of the program on fellows' daily leadership opportunities. Between January 2011 and January 2015, 15 Ugandan fellows (nine doctors and six nurses) participated in the program. Each fellow received 8 weeks of didactic modules held at one of the African partner institutions and three online modules to enhance fellows' foundation in leadership, communication, monitoring and evaluation, health informatics, research methodology, grant writing, implementation science, and responsible conduct of research. In addition, fellows embarked on innovative projects that covered a wide spectrum of global health challenges including critical analysis of policy formulation and review processes

  19. Resources for Smokeless Tobacco Education.

    Science.gov (United States)

    Laflin, Molly; And Others

    1987-01-01

    Pamphlets, posters, films, videotapes, slide/tape programs, models, teaching guides and packets, booklets, and other resources for smokeless tobacco education are listed. Many of the resources are from nonprofit agencies and are free or minimal cost. (CB)

  20. Assessing Climate Change Impacts on Water Resources and Colorado Agriculture Using an Equilibrium Displacement Mathematical Programming Model

    Directory of Open Access Journals (Sweden)

    Eihab Fathelrahman

    2014-06-01

    Full Text Available This research models selected impacts of climate change on Colorado agriculture several decades in the future, using an Economic Displacement Mathematical Programming model. The agricultural economy in Colorado is dominated by livestock, which accounts for 67% of total receipts. Crops, including feed grains and forages, account for the remainder. Most agriculture is based on irrigated production, which depends on both groundwater, especially from the Ogallala aquifer, and surface water that comes from runoff derived from snowpack in the Rocky Mountains. The analysis is composed of a Base simulation, designed to represent selected features of the agricultural economy several decades in the future, and then three alternative climatic scenarios are run. The Base starts with a reduction in agricultural water by 10.3% from increased municipal and industrial water demand, and assumes a 75% increase in corn extracted-ethanol production. From this, the first simulation (S1 reduces agricultural water availability by a further 14.0%, for a combined decrease of 24.3%, due to climatic factors and related groundwater depletion. The second simulation (S2-WET describes wet year conditions, which negatively affect yields of irrigated corn and milking cows, but improves yields for important crops such as non-irrigated wheat and forages. In contrast, the third simulation (S3-DRY describes a drought year, which leads to reduced dairy output and reduced corn and wheat. Consumer and producer surplus losses are approximately $10 million in this simulation. The simulation results also demonstrate the importance of the modeling trade when studying climate change in a small open economy, and of linking crop and livestock activities to quantify overall sector effects. This model has not taken into account farmers’ adaptation strategies, which would reduce the climate impact on yields, nor has it reflected climate-induced shifts in planting decisions and production

  1. Developing basic educational standards for educational resources for master\\'s degree program in \\'nursing neonatal intensive care\\': Report of a Delphi study

    Directory of Open Access Journals (Sweden)

    m ghorbanzadeh

    2016-07-01

    Full Text Available Introduction: Using the adequate and standardized educational facilities and spaces can ensure effective educational program. The purpose of the current study was developing basic educational standards for master's degree program in 'nursing neonatal intensive care'. Methods: This study is a descriptive study used Delphi approach to conduct with the participation of 40 experts in nursing neonatal intensive care from all over Iran in 2014. The study population consisted of neonatologists and medical professionals, administrators of educational department, faculties of pediatrics department, head nurses of neonatal intensive care unit, students and graduates of course in nursing neonatal intensive care were selected purposively. Firstly, the educational standards (24 items were gathered with extensive review and secondly, experts commented to questionnaire in three rounds. The first and second rounds were performed in a meeting with participation of 20 experts from Mashhad University of Medical Sciences and the third round was performance through sending emails to 40 experts from all over Iran. Results: In the third round, 10 basic education standards for students of master's degree program in 'nursing neonatal intensive care' unit have been agreed. The standards included theoretical training classes, equipped center for clinical skills, educational workshops, evidence-based learning environment, sufficient number of beds for neonatal intensive care unit, specialized books/ study hall school and hospital, wireless Internet, shared databases, and research approved process. Conclusion: These findings can be used to evaluate the educational resources in schools, which had courses of sciences degrees and it can be a good pattern for the standardization of other majors.

  2. Optimal operating rules definition in complex water resource systems combining fuzzy logic, expert criteria and stochastic programming

    Science.gov (United States)

    Macian-Sorribes, Hector; Pulido-Velazquez, Manuel

    2016-04-01

    This contribution presents a methodology for defining optimal seasonal operating rules in multireservoir systems coupling expert criteria and stochastic optimization. Both sources of information are combined using fuzzy logic. The structure of the operating rules is defined based on expert criteria, via a joint expert-technician framework consisting in a series of meetings, workshops and surveys carried out between reservoir managers and modelers. As a result, the decision-making process used by managers can be assessed and expressed using fuzzy logic: fuzzy rule-based systems are employed to represent the operating rules and fuzzy regression procedures are used for forecasting future inflows. Once done that, a stochastic optimization algorithm can be used to define optimal decisions and transform them into fuzzy rules. Finally, the optimal fuzzy rules and the inflow prediction scheme are combined into a Decision Support System for making seasonal forecasts and simulate the effect of different alternatives in response to the initial system state and the foreseen inflows. The approach presented has been applied to the Jucar River Basin (Spain). Reservoir managers explained how the system is operated, taking into account the reservoirs' states at the beginning of the irrigation season and the inflows previewed during that season. According to the information given by them, the Jucar River Basin operating policies were expressed via two fuzzy rule-based (FRB) systems that estimate the amount of water to be allocated to the users and how the reservoir storages should be balanced to guarantee those deliveries. A stochastic optimization model using Stochastic Dual Dynamic Programming (SDDP) was developed to define optimal decisions, which are transformed into optimal operating rules embedding them into the two FRBs previously created. As a benchmark, historical records are used to develop alternative operating rules. A fuzzy linear regression procedure was employed to

  3. Fiber resources

    Science.gov (United States)

    P. J. Ince

    2004-01-01

    In economics, primary inputs or factors of production define the term ‘resources.’ Resources include land resources (plants, animals, and minerals), labor, capital, and entrepreneurship. Almost all pulp and paper fiber resources are plant materials obtained from trees or agricultural crops. These resources encompass plant materials harvested directly from the land (...

  4. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Inspiring Quality Initiative Resources Continuous Quality Improvement ACS Clinical Scholars in Residence AHRQ Safety Program for ISCR ... Advocacy Efforts Cancer Liaison Program Cancer Programs Conference Clinical Research Program Commission on Cancer National Accreditation Program ...

  5. Space Resource Roundtable Rationale

    Science.gov (United States)

    Duke, Michael

    1999-01-01

    Recent progress in the U.S. Space Program has renewed interest in space resource issues. The Lunar Prospector mission conducted in NASA's Discovery Program has yielded interesting new insights into lunar resource issues, particularly the possibility that water is concentrated in cold traps at the lunar poles. This finding has not yet triggered a new program of lunar exploration or development, however it opens the possibility that new Discovery Missions might be viable. Several asteroid missions are underway or under development and a mission to return samples from the Mars satellite, Phobos, is being developed. These exploration missions are oriented toward scientific analysis, not resource development and utilization, but can provide additional insight into the possibilities for mining asteroids. The Mars Surveyor program now includes experiments on the 2001 lander that are directly applicable to developing propellants from the atmosphere of Mars, and the program has solicited proposals for the 2003/2005 missions in the area of resource utilization. These are aimed at the eventual human exploration of Mars. The beginning of construction of the International Space Station has awakened interest in follow-on programs of human exploration, and NASA is once more studying the human exploration of Moon, Mars and asteroids. Resource utilization will be included as objectives by some of these human exploration programs. At the same time, research and technology development programs in NASA such as the Microgravity Materials Science Program and the Cross-Enterprise Technology Development Program are including resource utilization as a valid area for study. Several major development areas that could utilize space resources, such as space tourism and solar power satellite programs, are actively under study. NASA's interests in space resource development largely are associated with NASA missions rather than the economic development of resources for industrial processes. That

  6. The clinical and economic impact of a sustained program in global plastic surgery: valuing cleft care in resource-poor settings.

    Science.gov (United States)

    Hughes, Christopher D; Babigian, Alan; McCormack, Susan; Alkire, Blake C; Wong, Anselm; Pap, Stephen A; Vincent, Jeffrey R; Meara, John G; Castiglione, Charles; Silverman, Richard

    2012-07-01

    The development of surgery in low- and middle-income countries has been limited by a belief that it is too expensive to be sustainable. However, subspecialist surgical care can provide substantial clinical and economic benefits in low-resource settings. The goal of this study is to describe the clinical and economic impact of recurrent short-term plastic surgical trips in low- and middle-income countries. The authors conducted a retrospective review of clinic and operative logbooks from Hands Across the World's surgical experience in Ecuador. The authors calculated the disability-adjusted life-years averted to estimate the clinical impact of cleft repair and then calculated the economic impact of surgical intervention for cleft disease. One thousand one hundred forty-two reconstructive surgical cases were performed over 15 years. Surgery was most commonly performed for scar contractures [449 cases (39.3 percent)], of which burn scars comprised a substantial amount [215 cases (18.8 percent)]. There were 40 postoperative complications within 7 days of operation (3.5 percent), and partial wound dehiscence was the most common complication [16 of 40 (40 percent)]. Cleft disorders constituted 277 cases (24.3 percent), and 102 cases were primary cleft lip and/or palate cases. Between 396 and 1042 total disability-adjusted life-years were averted through surgery for these 102 cases of primary cleft repair. This translates to an economic benefit between $4.7 million (human capital approach) and $27.5 million (value of a statistical life approach). Plastic surgical disease is a significant source of morbidity for patients in resource-limited regions. Dedicated programs that provide essential reconstructive surgery can produce substantial clinical and economic benefits to host countries.

  7. Human and equipment resources for difficult airway management, airway education programs, and capnometry use in Japanese emergency departments: a nationwide cross-sectional study.

    Science.gov (United States)

    Ono, Yuko; Tanigawa, Koichi; Shinohara, Kazuaki; Yano, Tetsuhiro; Sorimachi, Kotaro; Inokuchi, Ryota; Shimada, Jiro

    2017-09-13

    Although human and equipment resources, proper training, and the verification of endotracheal intubation are vital elements of difficult airway management (DAM), their availability in Japanese emergency departments (EDs) has not been determined. How ED type and patient volume affect DAM preparation is also unclear. We conducted the present survey to address this knowledge gaps. This nationwide cross-sectional study was conducted from April to September 2016. All EDs received a mailed questionnaire regarding their DAM resources, airway training methods, and capnometry use for tube placement. Outcome measures were the availability of: (1) 24-h in-house back-up; (2) key DAM resources, including a supraglottic airway device (SGA), a dedicated DAM cart, surgical airway devices, and neuromuscular blocking agents; (3) anesthesiology rotation as part of an airway training program; and (4) the routine use of capnometry to verify tube placement. EDs were classified as academic, tertiary, high-volume (upper quartile of annual ambulance visits), and urban. Of the 530 EDs, 324 (61.1%) returned completed questionnaires. The availability of in-house back-up coverage, surgical airway devices, and neuromuscular blocking agents was 69.4, 95.7, and 68.5%, respectively. SGAs and dedicated DAM carts were present in 51.5 and 49.7% of the EDs. The rates of routine capnometry use (47.8%) and the availability of an anesthesiology rotation (38.6%) were low. The availability of 24-h back-up coverage was significantly higher in academic EDs and tertiary EDs in both the crude and adjusted analysis. Similarly, neuromuscular blocking agents were more likely to be present in academic EDs, high-volume EDs, and tertiary EDs; and the rate of routine use of capnometry was significantly higher in tertiary EDs in both the crude and adjusted analysis. In Japanese EDs, the rates of both the availability of SGAs and DAM carts and the use of routine capnometry to confirm tube placement were approximately

  8. Bechtel Jacobs Company LLC Sampling and Analysis Plan for the Water Resources Restoration Program for Fiscal Year 2009, Oak Ridge Reservation, Oak Ridge, Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    Ketelle R.H.

    2008-09-25

    The Oak Ridge Reservation (ORR) Water Resources Restoration Program (WRRP) was established by the U. S. Department of Energy (DOE) in 1996 to implement a consistent approach to long-term environmental monitoring across the ORR. The WRRP has four principal objectives: (1) to provide the data and technical analysis necessary to assess the performance of completed Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) actions on the ORR; (2) to perform monitoring to establish a baseline against which the performance of future actions will be gauged and to support watershed management decisions; (3) to perform interim-status and post-closure permit monitoring and reporting to comply with Resource Conservation and Recovery Act of 1976 (RCRA) requirements; and (4) to support ongoing waste management activities associated with WRRP activities. Water quality projects were established for each of the major facilities on the ORR: East Tennessee Technology Park (ETTP); Oak Ridge National Laboratory (ORNL), including Bethel Valley and Melton Valley; and the Y-12 National Security Complex (Y-12 Complex or Y-12), including Bear Creek Valley (BCV), Upper East Fork Poplar Creek (UEFPC), and Chestnut Ridge. Off-site (i.e., located beyond the ORR boundary) sampling requirements are also managed as part of the Y-12 Water Quality Project (YWQP). Offsite locations include those at Lower East Fork Poplar Creek (LEFPC), the Clinch River/Poplar Creek (CR/PC), and Lower Watts Bar Reservoir (LWBR). The Oak Ridge Associated Universities (ORAU) South Campus Facility (SCF) is also included as an 'off-site' location, although it is actually situated on property owned by DOE. The administrative watersheds are shown in Fig. A.l (Appendix A). The WRRP provides a central administrative and reporting function that integrates and coordinates the activities of the water quality projects, including preparation and administration of the WRRP Sampling and

  9. Information resources

    Science.gov (United States)

    Friend, Milton; Franson, J. Christian; Friend, Milton; Gibbs, Samantha E.J.; Wild, Margaret A.

    2015-10-19

    During recent decades, natural resources agency personnel and others involved with the management and stewardship of wildlife have experienced an increasing need to access information and obtain technical assistance for addressing a diverse array of wildlife disease issues. This Chapter provides a broad overview of selected sources for obtaining supplemental information and technical assistance for addressing wildlife disease issues in North America. Specifically, examples of existing major wildlife disease programs focusing on free-ranging wildlife populations are highlighted; training opportunities for enhancing within-agency wildlife disease response are identified; a selected reading list of wildlife disease references is provided; and selected Web sites providing timely information on wildlife disease are highlighted. No attempt is made to detail all the North American programs and capabilities that address disease in free-ranging wildlife populations. Instead, this Chapter is focused on enhancing awareness of the types of capabilities that exist as potential sources for assistance and collaboration between wildlife conservation agency personnel and others in addressing wildlife disease issues.

  10. Development of a fuzzy-stochastic programming with Green Z-score criterion method for planning water resources systems with a trading mechanism.

    Science.gov (United States)

    Zeng, X T; Huang, G H; Li, Y P; Zhang, J L; Cai, Y P; Liu, Z P; Liu, L R

    2016-12-01

    This study developed a fuzzy-stochastic programming with Green Z-score criterion (FSGZ) method for water resources allocation and water quality management with a trading-mechanism (WAQT) under uncertainties. FSGZ can handle uncertainties expressed as probability distributions, and it can also quantify objective/subjective fuzziness in the decision-making process. Risk-averse attitudes and robustness coefficient are joined to express the relationship between the expected target and outcome under various risk preferences of decision makers and systemic robustness. The developed method is applied to a real-world case of WAQT in the Kaidu-Kongque River Basin in northwest China, where an effective mechanism (e.g., market trading) to simultaneously confront severely diminished water availability and degraded water quality is required. Results of water transaction amounts, water allocation patterns, pollution mitigation schemes, and system benefits under various scenarios are analyzed, which indicate that a trading-mechanism is a more sustainable method to manage water-environment crisis in the study region. Additionally, consideration of anthropogenic (e.g., a risk-averse attitude) and systemic factors (e.g., the robustness coefficient) can support the generation of a robust plan associated with risk control for WAQT when uncertainty is present. These findings assist local policy and decision makers to gain insights into water-environment capacity planning to balance the basin's social and economic growth with protecting the region's ecosystems.

  11. Programa Estrategico do desenvolvimento 1968-70: Area Estrategica IX. Infra-estructura Social. Educacao e Recursos Humanos, 1 e 2 (Strategic Development Program 1968-1970: Strategic Area IX. Education and Human Resources, Volumes 1 & 2).

    Science.gov (United States)

    Brazil.

    This document is an English-language abstract (approximately 1,500 words) of a two volume work dealing with education and human resources as part of the Brazilian Government's Strategic Development Program 1968-70. It offers an integral view of education as an instrument of social transformation and an exposition of the quantitative and…

  12. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Quality Improvement Program About Standards Apply Participant Use Data File (PUF) Resources & FAQs Find a MBSAQIP Center ... Programs BleedingControl.org Trauma Quality Programs National Trauma Data Bank Trauma Quality Improvement Program Mentoring for Excellence ...

  13. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Overview of Cancer Programs Cancer Programs News American Joint Committee on Cancer Cancer Advocacy Efforts Cancer Liaison ... Validation Programs Accredited Education Institutes CME Accreditation CME Joint Providership Program Verification of Knowledge and Skills Resources ...

  14. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... CME Accreditation CME Joint Providership Program Verification of Knowledge and Skills Resources Educational Resources Educational Resources E- ... Disaster Management and Emergency Preparedness Rural Trauma Team Development Course Trauma Evaluation and Management Trauma CME Nora ...

  15. Root Cause Analyses of Nunn-McCurdy Breaches. Volume 2: Excalibur Artillery Projectile and the Navy Enterprise Resource Planning Program, with an Approach to Analyzing Program Complexity and Risk

    Science.gov (United States)

    2012-01-01

    extraordinarily helpful discussions about the program. We thank John McNair and Dennis Taitano for their insights regarding the creation and expectations of...Program Deviation Report PEO-AMMO Program Executive Officer for Ammunition PMP parts management program POM Program Objectives Memorandum RCA root cause

  16. Business Planning for Cultural Heritage Institutions. A Framework and Resource Guide to Assist Cultural Heritage Institutions with Business Planning for Sustainability of Digital Asset Management Programs

    Science.gov (United States)

    Bishoff, Liz; Allen, Nancy

    2004-01-01

    The purpose of this document is to present a framework and resource guide to help cultural heritage institutions plan sustainable access to their digital cultural assets and to do so by means that link their missions to planning modes and models. To aid cultural heritage organizations in the business-planning process, this resource will do the…

  17. Erratum for “Using Stochastic Dynamic Programming to Support Water Resources Management in the Ziya River Basin, China” by Claus Davidsen, Silvio J. Pereira-Cardenal, Suxia Liu, Xingguo Mo, Dan Rosbjerg, and Peter Bauer-Gottwein

    DEFF Research Database (Denmark)

    Davidsen, Claus; Cardenal, Silvio Javier Pereira; Liu, Suxia

    2015-01-01

    in stricter water management. The results show that the SNWTP reduces the impacts of water scarcity and impacts optimal water management in the basin. The presented modeling framework provides an objective basis for the development of tools to avoid overpumping groundwater resources at minimum costs.......Water scarcity and rapid economic growth have increased the pressure on water resources and environment in Northern China, causing decreased groundwater tables, ecosystem degradation, and direct economic losses due to insufficient water supply. The authors applied the water value method, a variant...... of stochastic dynamic programming, to optimize water resources management in the Ziya River basin. Natural runoff from the upper basin was estimated with a rainfall-runoff model autocalibrated using in situ measured discharge. The runoff serial correlation was described by a Markov chain and used as input...

  18. 77 FR 59197 - Epilepsy Program

    Science.gov (United States)

    2012-09-26

    ... HUMAN SERVICES Health Resources and Services Administration Epilepsy Program AGENCY: Health Resources and Services Administration, HHS. ACTION: Notice of Noncompetitive Program Expansion Supplement Award... Program to the Epilepsy Foundation of America (U23MC19824) to support additional evaluation activities...

  19. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume III. Resources and fuel cycle facilities

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    The ability of uranium supply and the rest of the nuclear fuel cycle to meet the demand for nuclear power is an important consideration in future domestic and international planning. Accordingly, the purpose of this assessment is to evaluate the adequacy of potential supply for various nuclear resources and fuel cycle facilities in the United States and in the world outside centrally planned economy areas (WOCA). Although major emphasis was placed on uranium supply and demand, material resources (thorium and heavy water) and facility resources (separative work, spent fuel storage, and reprocessing) were also considered.

  20. Safety Resources.

    Science.gov (United States)

    Hoot, James L.; Bartkowiak, Elaine T.

    1994-01-01

    Lists 72 organizations and programs that deal with child safety, grouped by the following categories: (1) general; (2) general violence; (3) gun violence; (4) media violence; (5) drugs and alcohol; (6) child abuse and at-risk children; (7) parenting programs; (8) community service programs; (9) leadership programs; (10) peer counseling; (11)…

  1. Minnesota's forest resources, 2006

    Science.gov (United States)

    P.D. Miles; D. Heinzen

    2007-01-01

    This publication provides an overview of forest resource attributes for Minnesota based on an annual inventory conducted by the Forest Inventory and Analysis program at the Northern Research Station of the U.S. Forest Service. These annual estimates, along with web-posted core tables, will be updated annually. For more information regarding past inventory reports for...

  2. Resource Mobilization

    International Development Research Centre (IDRC) Digital Library (Canada)

    This practical guidebook supports and promotes new and creative thinking on resource mobilization for ... sources and come up with creative resource mobilization strategies to ensure survival. The Importance of ...... funds had already been earmarked for buying new classroom facilities. Maintain integrity of auction. 2.

  3. Mineral resources

    NARCIS (Netherlands)

    Henckens, M.L.C.M.; Ierland, van E.C.; Driessen, P.P.J.; Worrell, E.

    2016-01-01

    The extractable ores of the world's geologically scarcest mineral resources (e.g. antimony, molybdenum and zinc) may be exhausted within several decades to a century, if their extraction continues to increase. This paper explores the likelihood that these scarce mineral resources can be conserved

  4. Survey of accredited master of public health (MPH) programs with health education concentrations: a resource for strengthening the public health workforce.

    Science.gov (United States)

    Woodhouse, Lynn D; Auld, M Elaine; Livingood, William C; Mulligan, Lori A

    2006-04-01

    The authors designed survey research to assess accredited master of public health (MPH) programs with health education concentrations. A Web-based survey was distributed to program directors and was used to collect characteristics of program faculty, students, graduates, internships, employment, and competency development. Results indicate that students and graduates are diverse; 72% of students complete internships and 61% of graduates work in government or community public health-related agencies; 98% of faculty hold a doctoral degree and 67% have at least one degree from an accredited public health school or program; and 85% of programs build competencies in most of the Institute of Medicine-suggested areas. The authors conclude that accredited MPH programs with a concentration in health education train diverse public health practitioners highly likely to work in a government or community public health agency with competencies to enhance public health.

  5. Science and the City: Community Cultural and Natural Resources at the Core of a Place-Based, Science Teacher Preparation Program

    Science.gov (United States)

    Miele, Eleanor A.; Powell, Wayne G.

    2010-01-01

    The departments of Geology and Education at Brooklyn College collaborated with five informal educational institutions in the development of a place-based graduate program for Earth science teachers. The team used "backward design" to develop a program of courses that are thematically structured and use a city-as-lab approach that places…

  6. Rethinking resources

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, W.L. [Univ. of Texas, Austin, TX (United States)

    1994-09-01

    We class energy and mineral resources as finite because we are reasonably certain that they do not form at a rate remotely approaching man`s rate of use. We have certain environments of the earth that have limits in carrying capacity, and we presume that the global environment does as well. These facts and presumptions, coupled with anxieties over growth in population and consumption, have posed pictures of impending catastrophe from Malthus through the Club of Rome and currently, among certain advocates of what is called sustainable development. To avoid future calamity, command and control management of resource use is urged by many. But, quite simply, such management would presume a wisdom that historical experience suggests does not exist. As a recent example, consider natural gas resources. A decade and a half ago, the resource base of natural gas in the United States was judged to be near exhaustion. Estimates of remaining resources by governmental agencies, academicians, and several major energy companies indicated the ultimate resource would be at about 100 tcf today, with essential depletion by the end of the century. Such was the near universal wisdom that compelled Congress to enact legislation to outright prohibit certain use of natural gas. Today, after nearly eight years of gas supply in excess of demand and with entirely new appreciation of the impact of technology, estimates of the remaining gas resource by industry, government, and others are an order of magnitude greater than those made just 15 yr ago, and the same government that then sought to husband a resource presumed to be near depletion now aggressively promotes its use and consumption. Limits to resources and limits to environmental carrying capacity do indeed exist, but we have yet to define those limits and the paths thereto.

  7. Mineral Resources

    OpenAIRE

    Ababsa, Myriam

    2014-01-01

    Jordan’s natural resources are very limited: water is scarce, there is little arable land and the country has few sources of energy (fig. I.11). Jordan’s mineral industry has a long history: flint was used in prehistoric times and early copper mining started in Wadi Faynan during the Chalcolithic Period. The following is a brief presentation of Jordan’s resources. Mining and investments will be studied in Part 3. Figure I.11 — Jordan Mineral Resources. NRA 2012 Phosphates The Jordanian Natur...

  8. Health Effects of Energy Resources

    Science.gov (United States)

    Orem, William; Tatu, Calin; Pavlovic, Nikola; Bunnell, Joseph; Kolker, Allan; Engle, Mark; Stout, Ben

    2010-01-01

    Energy resources (coal, oil, and natural gas) are among the cornerstones of modern industrial society. The exploitation of these resources, however, is not without costs. Energy materials may contain harmful chemical substances that, if mobilized into air, water, or soil, can adversely impact human health and environmental quality. In order to address the issue of human exposure to toxic substances derived from energy resources, the U.S. Geological Survey (USGS) Energy Resources Program developed a project entitled 'Impacts of Energy Resources on Human Health and Environmental Quality.' The project is intended to provide policymakers and the public with the scientific information needed to weigh the human health and environmental consequences of meeting our energy needs. This fact sheet discusses several areas where the USGS Energy Resources Program is making scientific advances in this endeavor.

  9. Primer on gas integrated resource planning

    Energy Technology Data Exchange (ETDEWEB)

    Goldman, C.; Comnes, G.A.; Busch, J.; Wiel, S. [Lawrence Berkeley Lab., CA (United States)

    1993-12-01

    This report discusses the following topics: gas resource planning: need for IRP; gas integrated resource planning: methods and models; supply and capacity planning for gas utilities; methods for estimating gas avoided costs; economic analysis of gas utility DSM programs: benefit-cost tests; gas DSM technologies and programs; end-use fuel substitution; and financial aspects of gas demand-side management programs.

  10. Genomic Resources for Cancer Epidemiology

    Science.gov (United States)

    This page provides links to research resources, complied by the Epidemiology and Genomics Research Program, that may be of interest to genetic epidemiologists conducting cancer research, but is not exhaustive.

  11. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... 2016 Annual Meeting Women's Committee Mentorship Program Outside Activities ACS Archives Contact Us Quality Programs Quality Programs ... Quality in Geriatric Surgery Project Project Goals and Activities Stakeholder Organizations Project Team Resources News Contact Us ...

  12. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Accreditation Program for Breast Centers About NAPBC Accreditation Education NAPBC Standards Cancer Programs News Quality in Geriatric ... 4 and Recertification SSR Login MIPS Resources and Education Quality and Safety Conference Trauma Trauma Programs Trauma ...

  13. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Conference Publications and Posters National Trauma System Injury Prevention and Control Quality and Safety Conference Quality and ... Safety Resources About the Patient Education Program The Recovery Room Choosing Wisely Educational Programs Educational Programs Educational ...

  14. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Data Bank Trauma Quality Improvement Program Mentoring for Excellence in Trauma Surgery Advanced Trauma Life Support Verification, ... Patients Medical Professionals Skills Programs Find a Treatment Center Patient Safety Resources About the Patient Education Program ...

  15. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... of Education ACS Education and Training Courses Publications Education Program Videos Contact Us Clinical Congress Clinical Congress 2017 ... Treatment Center Patient Safety Resources About the Patient Education Program The Recovery Room Choosing Wisely Educational Programs Educational ...

  16. Determining the Science, Agriculture and Natural Resource, and Youth Leadership Outcomes for Students Participating in an Innovative Middle School Agriscience Program

    Science.gov (United States)

    Skelton, Peter; Stair, Kristin S.; Dormody, Tom; Vanleeuwen, Dawn

    2014-01-01

    The Memorial Middle School Agricultural Extension and Education Center (MMSAEEC) located in Las Vegas, New Mexico is a youth science center focusing on agriculture and natural resources. The purpose of this quasi-experimental study of the MMSAEEC teaching and learning model was to determine if differences exist in science achievement, agriculture…

  17. Arthritis - resources

    Science.gov (United States)

    Resources - arthritis ... The following organizations provide more information on arthritis : American Academy of Orthopaedic Surgeons -- orthoinfo.aaos.org/menus/arthritis.cfm Arthritis Foundation -- www.arthritis.org Centers for Disease Control and Prevention -- www. ...

  18. Seaweed resources

    Digital Repository Service at National Institute of Oceanography (India)

    Deshmukhe, G.V.; Dhargalkar, V.K.; Untawale, A

    The chapter summarizes our present knowledge of the seaweed resources of the Indian Ocean region with regard to the phytogeographical distribution, composition, biomass, utilization, cultivation, conservation and management. The voluminous data...

  19. Hemophilia - resources

    Science.gov (United States)

    Resources - hemophilia ... The following organizations provide further information on hemophilia : Centers for Disease Control and Prevention -- www.cdc.gov/ncbddd/hemophilia/index.html National Heart, Lung, and Blood Institute -- www.nhlbi.nih.gov/ ...

  20. Depression - resources

    Science.gov (United States)

    Resources - depression ... Depression is a medical condition. If you think you may be depressed, see a health care provider. ... following organizations are good sources of information on depression : American Psychological Association -- www.apa.org/topics/depress/ ...

  1. Diabetes - resources

    Science.gov (United States)

    Resources - diabetes ... The following sites provide further information on diabetes: American Diabetes Association -- www.diabetes.org Juvenile Diabetes Research Foundation International -- www.jdrf.org National Center for Chronic Disease Prevention and Health Promotion -- ...

  2. Prostate Cancer Pathology Resource Network

    Science.gov (United States)

    2015-12-01

    AD_________________ Award Number: W81XWH-10-2-0056 TITLE: Prostate Cancer Pathology Resource Network PRINCIPAL INVESTIGATOR: Bruce J. Trock, Ph.D... Pathology Resource Network 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-10-2-0056 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Bruce J. Trock, Ph.D. Betty...The Prostate Cancer Pathology Resource Network (which has since been renamed the Prostate Cancer Biorepository Network or PCBN) is a collaboration

  3. Forest Resources

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-06-01

    Forest biomass is an abundant biomass feedstock that complements the conventional forest use of wood for paper and wood materials. It may be utilized for bioenergy production, such as heat and electricity, as well as for biofuels and a variety of bioproducts, such as industrial chemicals, textiles, and other renewable materials. The resources within the 2016 Billion-Ton Report include primary forest resources, which are taken directly from timberland-only forests, removed from the land, and taken to the roadside.

  4. Quantifying resource use in computations

    NARCIS (Netherlands)

    van Son, R.J.J.H.

    2009-01-01

    It is currently not possible to quantify the resources needed to perform a computation. As a consequence, it is not possible to reliably evaluate the hardware resources needed for the application of algorithms or the running of programs. This is apparent in both computer science, for in- stance, in

  5. Interdisciplinary Methods in Water Resources

    Science.gov (United States)

    Cosens, Barbara; Fiedler, Fritz; Boll, Jan; Higgins, Lorie; Johnson, Gary; Kennedy, Brian; Strand, Eva; Wilson, Patrick; Laflin, Maureen

    2011-01-01

    In the face of a myriad of complex water resource issues, traditional disciplinary separation is ineffective in developing approaches to promote a sustainable water future. As part of a new graduate program in water resources, faculty at the University of Idaho have developed a course on interdisciplinary methods designed to prepare students for…

  6. Towards Automatic Resource Bound Analysis for OCaml

    OpenAIRE

    Hoffmann, Jan; Das, Ankush; Weng, Shu-Chun

    2016-01-01

    This article presents a resource analysis system for OCaml programs. This system automatically derives worst-case resource bounds for higher-order polymorphic programs with user-defined inductive types. The technique is parametric in the resource and can derive bounds for time, memory allocations and energy usage. The derived bounds are multivariate resource polynomials which are functions of different size parameters that depend on the standard OCaml types. Bound inference is fully automatic...

  7. Genetic toxicology: web resources.

    Science.gov (United States)

    Young, Robert R

    2002-04-25

    Genetic toxicology is the scientific discipline dealing with the effects of chemical, physical and biological agents on the heredity of living organisms. The Internet offers a wide range of online digital resources for the field of Genetic Toxicology. The history of genetic toxicology and electronic data collections are reviewed. Web-based resources at US National Library of Medicine (NLM), including MEDLINE, PUBMED, Gateway, Entrez, and TOXNET, are discussed. Search strategies and Medical Subject Headings (MeSH) are reviewed in the context of genetic toxicology. The TOXNET group of databases are discussed with emphasis on those databases with genetic toxicology content including GENE-TOX, TOXLINE, Hazardous Substances Data Bank, Integrated Risk Information System, and Chemical Carcinogenesis Research Information System. Location of chemical information including chemical structure and linkage to health and regulatory information using CHEMIDPLUS at NLM and other databases is reviewed. Various government agencies have active genetic toxicology research programs or use genetic toxicology data to assist fulfilling the agency's mission. Online resources at the US Food and Drug Administration (FDA), the US Environmental Protection Agency (EPA), the National Institutes of Environmental Health Sciences, and the National Toxicology Program (NTP) are outlined. Much of the genetic toxicology for pharmaceuticals, industrial chemicals and pesticides that is performed in the world is regulatory-driven. Regulatory web resources are presented for the laws mandating testing, guidelines on study design, Good Laboratory Practice (GLP) regulations, and requirements for electronic data collection and reporting. The Internet provides a range of other supporting resources to the field of genetic toxicology. The web links for key professional societies and journals in genetic toxicology are listed. Distance education, educational media resources, and job placement services are also

  8. Cultural Resource Test Sampling Program for a Proposed Flood Control Project in the Lower San Luis Rey River Drainage, Oceanside, California.

    Science.gov (United States)

    1979-10-01

    SCIENTIFIC NAME COMMON NAME ENVIRONMENT Donax gouldii california Bean Clam Open Beach Aequipecten sp. Pecten Mud Flats Chione spp. . californiensis Banded...gross and 57.1 percent of the total) at W-1838 is evidence of resource procurement along the open beach environment. Donax occurred in large amounts...cursory analysis of their cosmological tales, shamanism, world- view, and numerous specialized religious ceremonies reveals a deep-rooted, well- conceived

  9. Environmental Impact Research Program. OSPREY (Pandion haliaetus). Section 4.3.1. US Army Corps of Engineers Wildlife Resources Management Manual.

    Science.gov (United States)

    1986-07-01

    299. Vaurie, C. 1965. The birds of the palearctic faunas: Non- passeriformes . Witherby, London. 763 pp. Wiemeyer, S. N., T. G. Lamont, and L. N. Locke...obsolete Unclassified p 18. SUBJECT TERMS (Continued). Pandioninae Osprey management Raptor management Wildlife management Birds of prey Wildlife resources...highly visible bird of prey that often lives in close association with man. In most situations, this is a harmonious association in which ospreys are

  10. National Coastal Geology Program: a plan of geologic research on coastal erosion, coastal wetlands, polluted sediments, and coastal hard-mineral resources

    Science.gov (United States)

    ,

    1990-01-01

    More than 50 percent of the U.S. population currently live within 50 miles of an ocean, Great Lake, or major estuary. According to forecasts, the concentration of people along our coastlines will continue to increase into the 21st century. In addition to residential and commercial buildings and facilities worth tens of billions of dollars, the coasts and associated wetlands are natural resources of tremendous value, with estimates in excess of $13 billion per year for commercial and recreational fisheries alone. Human activities and natural processes are stressing the coastal environment. * Each of the coastal states and island territories is suffering problems related to coastal erosion. * Deterioration of wetlands is widespread and of great public concern. * Pollutants carried by rivers or runoff are discharged directly into coastal waters and accumulate in the sediments on the sea floor, in some areas causing damage to living resources and presenting a threat to public health. * Onshore sources for hard-mineral resources, such as sand and gravel used for construction purposes, are becoming increasingly difficult to find. New sources are being sought in coastal waters. Coastal issues will become even more important into the next century if sea level is significantly influenced by climate change and other factors.

  11. Resource Conservation and Recovery Act Information (RCRAInfo)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Resource Conservation and Recovery Act Information (RCRAInfo) system contains information reported to the state environmental programs on activities and cleanup...

  12. Interpersonal and economic resources.

    Science.gov (United States)

    Foa, U G

    1971-01-29

    High population density and increased institutional specialization, which are relatively novel features of human society. have provided conditions for a more efficient exchange of universalistic resources, while decreasing the opportunity for exchanging particularistic ones. The parallel with physical environment is striking: in both cases technology has created new problems in the process of solving old ones. Whether it is natural resources or interpersonal resources, physical ecology or social ecology, recognizing and defining the new problem is the first step toward its solution. The importance of particularistic resources in solving problems of modern society has scarcely been recognized. Welfare institutions, for example, often require clients to lose status for the money they receive. This form of exchange deprives the client of a resource which is already scarce for him, thus further reducing his chances of autonomous performance as a resource exchanger in society. By ignoring the significance of particularistic resources for social functioning, we tend to see the solution of social problems exclusively in terms of a better distribution of economic resources. Improvement of education, for instance, is considered almost equivalent to allocating more money for schools. Truly money is one of the neighbors of information in the order, but the other one is status. Evidence to suggest that higher status improves educational achievement has, indeed, been repeatedly reported (26). The very mention of particularistic resources in social planning causes uneasiness and bafflement. The economist Levitan (27), for example, in reviewing the activities of VISTA (a program of the Office of Economic Opportunity), wonders how to evaluate goals such as dedication, involvement, and good feeling. The reluctance to include particularistic resources in social engineering will hopefully decrease as we improve techniques for their observation and measurement and as we begin to

  13. Information Technology Resources Assessment

    Energy Technology Data Exchange (ETDEWEB)

    1993-04-01

    The Information Technology Resources Assessment (ITRA) is being published as a companion document to the Department of Energy (DOE) FY 1994--FY 1998 Information Resources Management Long-Range Plan. This document represents a collaborative effort between the Office of Information Resources Management and the Office of Energy Research that was undertaken to achieve, in part, the Technology Strategic Objective of IRM Vision 21. An integral part of this objective, technology forecasting provides an understanding of the information technology horizon and presents a perspective and focus on technologies of particular interest to DOE program activities. Specifically, this document provides site planners with an overview of the status and use of new information technology for their planning consideration.

  14. Requirements for the Success of the Integration Program of Disabled Students in the Regular Schools from the Perspective of the Teachers of the Learning Resources Rooms

    Science.gov (United States)

    At-Turki, Jihad; Ali ALdmour, Hisham; Al Maitah, Khalil A. R.; ALsarayreh, Mohammad Nayef

    2012-01-01

    The purpose of this study is to identify the requirements for the success of the integration program and to find out the causes of success and to provide optimal services for the students with disabilities in regular schools. The study attempts to answer the following questions: (1) What are the most important requirements of the success of the…

  15. Translanguaging Practices as Mobilization of Linguistic Resources in a Spanish/English Bilingual After-School Program: An Analysis of Contradictions

    Science.gov (United States)

    Martínez-Roldán, Carmen María

    2015-01-01

    This article discusses the results of an empirical study that examined the translanguaging practices of primary-grade, bilingual Latino students, as mediated by bilingual teacher candidates (TCs), in an after-school program in the southwestern United States. Expansive Learning theory, within the cultural-historical activity tradition, guided the…

  16. Web-based public health geographic information systems for resources-constrained environment using scalable vector graphics technology: a proof of concept applied to the expanded program on immunization data

    Directory of Open Access Journals (Sweden)

    Kamadjeu Raoul

    2006-06-01

    Full Text Available Abstract Background Geographic Information Systems (GIS are powerful communication tools for public health. However, using GIS requires considerable skill and, for this reason, is sometimes limited to experts. Web-based GIS has emerged as a solution to allow a wider audience to have access to geospatial information. Unfortunately the cost of implementing proprietary solutions may be a limiting factor in the adoption of a public health GIS in a resource-constrained environment. Scalable Vector Graphics (SVG is used to define vector-based graphics for the internet using XML (eXtensible Markup Language; it is an open, platform-independent standard maintained by the World Wide Web Consortium (W3C since 2003. In this paper, we summarize our methodology and demonstrate the potential of this free and open standard to contribute to the dissemination of Expanded Program on Immunization (EPI information by providing interactive maps to a wider audience through the Internet. Results We used SVG to develop a database driven web-based GIS applied to EPI data from three countries of WHO AFRO (World Health Organization – African Region. The system generates interactive district-level country immunization coverage maps and graphs. The approach we describe can be expanded to cover other public health GIS demanding activities, including the design of disease atlases in a resources-constrained environment. Conclusion Our system contributes to accumulating evidence demonstrating the potential of SVG technology to develop web-based public health GIS in resources-constrained settings.

  17. West Virginia US Department of Energy experimental program to stimulate competitive research. Section 2: Human resource development; Section 3: Carbon-based structural materials research cluster; Section 3: Data parallel algorithms for scientific computing

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-02

    This report consists of three separate but related reports. They are (1) Human Resource Development, (2) Carbon-based Structural Materials Research Cluster, and (3) Data Parallel Algorithms for Scientific Computing. To meet the objectives of the Human Resource Development plan, the plan includes K--12 enrichment activities, undergraduate research opportunities for students at the state`s two Historically Black Colleges and Universities, graduate research through cluster assistantships and through a traineeship program targeted specifically to minorities, women and the disabled, and faculty development through participation in research clusters. One research cluster is the chemistry and physics of carbon-based materials. The objective of this cluster is to develop a self-sustaining group of researchers in carbon-based materials research within the institutions of higher education in the state of West Virginia. The projects will involve analysis of cokes, graphites and other carbons in order to understand the properties that provide desirable structural characteristics including resistance to oxidation, levels of anisotropy and structural characteristics of the carbons themselves. In the proposed cluster on parallel algorithms, research by four WVU faculty and three state liberal arts college faculty are: (1) modeling of self-organized critical systems by cellular automata; (2) multiprefix algorithms and fat-free embeddings; (3) offline and online partitioning of data computation; and (4) manipulating and rendering three dimensional objects. This cluster furthers the state Experimental Program to Stimulate Competitive Research plan by building on existing strengths at WVU in parallel algorithms.

  18. Ostomy Home Skills Program

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  19. Ostomy Home Skills Program

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