WorldWideScience

Sample records for program irp stage

  1. Installation-restoration program (IRP) Stage 7, remedial investigation/feasibility study comprehensive CERCLA work plan for McClellan AFB/EM, McClellan AFB, California. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1991-07-01

    In 1979, officials at McClellan Air Force Base (AFB) in California began to suspect that past waste disposal practices may be contaminating the ground water in the area. At least four areas of potential ground water contamination needing further investigation. A comprehensive program was developed to maintain drinking water quality and to remediate the contamination. Through the operation and maintenance of aircraft, McClellan AFB has been engaged in operations that involve the use, storage, and disposal of hazardous materials including: industrial solvents, caustic cleaners, electroplating chemicals, heavy metals, polychlorinated biphenyls (PCBs), low-level radioactive wastes, and a variety of fuel oils and lubricants. Hazardous substances have percolated into aquifers. Ground water testing identified the presence of volatile organic compounds in on- and off-base wells. Surface water drainage includes several creeks within the area watersheds. These creeks receive contaminants and toxic hazards from on base drainage and then in turn merge with several tributaries, and exit to the west.

  2. Developing Critical Thinking Skills through Interactive Radio Programs (IRPs: Building Online Knowledge Networks In Distance Education

    Directory of Open Access Journals (Sweden)

    Gulsun KURUBACAK

    2005-07-01

    Full Text Available ABSTRACT In considering how best to optimize distance education systems, economy (cost effectiveness and efficiency, technology (communication technologies and equity (gender, accessibility, minority, language, religion etc. are vital issues in any distance education systems. Moreover, how end-users, distance learners, can equally share and exchange knowledge and resources for educational purposes, how they can promote their higher-order thinking skills as well as how they can cope with the limitations they have (such as time, age, gender, language etc. are major concerns in distance education milieus. Kurubacak strongly emphasize that interactive radio programs, as a forgotten educational media, with a little cost can effectively integrate in any distance education systems. Therefore, the main purpose of this paper is to focus on interactive radio programs to build critical and creative knowledge networks among diverse learners in the distance education systems of developing countries.

  3. Installation Restoration Program (IRP). Phase II -- Confirmation/Quantification, Stage 2 for Langley Air Force Base, Virginia.

    Science.gov (United States)

    1985-07-30

    Vennard, J.K. and R.L. Street. 1975. Elementary Fluid Mechanics. John Wiley and Sons, Inc., New York, New York. 740 pp. Virginia Water Quality...ppm F3en:zene 0.0002 ppm To] uene 0.0002 ppm The condition,-= of the BTX analysis are according to EPA Method 602 - Purgeable Aroma tics. • . SEE

  4. Handbook to Support the Installation Restoration Program (IRP) statements of Work. Volume 1. Remedial Investigation/Feasibility Studies (RI/FS)

    Science.gov (United States)

    1991-05-01

    terrestrial receptors contact surface water bodies for such reasons as drinking, development through some of the life stages (e.g., tadpole stage of...indirectly by observing changes (i.e., adenosine triphosphate lATPh content or the bioluminescence) in the characteristics of microbes . ATP is found in...by Microbics Corporation). Pure Microtox reagent (living bacteria) emits light. When toxic material is added to the reagent, the light output drops

  5. Shemya AFB, Alaska 1992 IRP field investigation report

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    The US Air Force is currently investigating 22 sites on Shemya Air Force Base (AFB) to determine if past spill and disposal activities have caused environmental damage. These investigations are being carried out under the Air Force's Installation Restoration Program (IRP). As a part of the IRP program, field investigations were performed in 1992 to obtain the information needed to assess what future actions willneed to be carried out at each site. The island's drinking water supply was also investigated. Activities completed at 10 selected sites during the 1992 field investigation included surface sampling to determine the lateral extent of contamination, subsurface sampling to determine the vertical extent of contamination, and the installation of well points and monitoring wells to determine the direction of groundwater flow and if the groundwater has been affected by a site. In addition, geophysical surveys were performed at most sites to identify site boundaries and check for the presence of buried metal to be avoided during drilling activities.

  6. 10 CFR 905.14 - Does Western require annual IRP progress reports?

    Science.gov (United States)

    2010-01-01

    ... projected goals and implementation schedules, and energy and capacity benefits and renewable energy... 10 Energy 4 2010-01-01 2010-01-01 false Does Western require annual IRP progress reports? 905.14 Section 905.14 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Integrated Resource...

  7. IRP: A love/hate relationship

    Energy Technology Data Exchange (ETDEWEB)

    Cordova, C.J.

    1995-03-01

    The spector of retail competition that is looming on the electric industry horizon is playing havoc with utility and public utility commission (PUC) attitudes toward DSM. Why is this happening, and what does it mean for gas utilities and the future of utility-sponsored DSM? and what`s going on from the broader viewpoint of integrated resource planning (IRP)? The paper explains how what appears to be conflicting utility views actually represents different interpretations of how to become a low-cost but customer-friendly provider of energy services. The paper also discusses the use of IRP as a strategic planning tool, learning to be proactive, and increasing expectations of consumers.

  8. Visiting Scholars Program | FNLCR Staging

    Science.gov (United States)

    The Visiting Scholars Program (VSP) is a scientific partnership program that offers extramural scientists access to the intellectual capital and state-of-the-art facilities of the Frederick National Laboratory for Cancer Research (FNLCR), the only na

  9. The role of IRP in the natural gas industry: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Wright, J.A.; Brockman, L.; Herman, P.

    1994-09-29

    The natural gas industry has changed radically over the last decade. The Federal Energy Regulatory Commission`s Order 636 completed plans to unbundle interstate pipeline services and create open access for distribution companies and their customers. There has also been increasing competition for local distribution companies (LDCs) from fuel oil, electricity and unregulated energy service companies. Meanwhile, the Energy Policy Act of 1992 includes provisions that encourage energy efficiency and promote reliance on competitive forces. In response to these changes, coupled with growing environmental concerns and the need for increased energy efficiency, a number of state public utility commissions and LDCs took an interest in integrated resource planning (IRP) for gas utilities. Gas IRP was in its formative stages and a variety of regulatory approaches were being considered when this project began. In response, this project originated with the total project scope being to define, implement and institutionalize an IRP process for the Gas Customer Service Business Unit of Niagara Mohawk Power Corporation (NMGas).

  10. Installation Restoration Program (IRP) Stage 3, Operable Unit B engineering Evaluation/Cost Analysis - Environmental Assessment for McClellan AFB/EM, McClellan AFB, California

    Science.gov (United States)

    1990-12-01

    I % -4I It0 , I 4 % I3 I 1 I f 0 -, ~ulb -~ 3/ zL~j iI’> ~ ~ 0 2w oa o-.. a. 00 ( -j 0jw Ltt Vo 13 d SONI/A 0 < LU crL-j ec*4: jw __ A6-2...calculation of the zone of capture for a pumping well. The equation of Keely and Tsang (1983) is the basis for determining well pumping rates. The...for calculation of the zone of capture for a pumping well. The equation of Keely and Tsang (1983) is the basis for the determining well pumping rates

  11. Installation Restoration Program (IRP) Stage 3. McClellan Air Force Base. Operable Unit B. Preliminary Assessment Summary Report. Volume 3. Appendices C, D & E

    Science.gov (United States)

    1991-10-01

    Isoortylthloglycolate Isopropyl alcohol lactic acid lanthanum lanthanum chloride lanthanum nitrate lanthanum oxide lead lead chloride lead nitrate lithium ... lithium chloride lithium fluoride lithium iodide lithium nitrate lutetium oxide magnesium magnesium chloride magnesium nitrate magnesium oxide malonlc acid...nitrate nickalous n;trate nioblum niobium oxalate niobium oxide nitric acid nttrobenzene nitroguanidlne orotic acid oxalic acid p-amlnobenzoic acid p

  12. Installation Restoration Program (IRP), Phase II, Stage 1 - Problem Confirmation Study, Norton Air Force Base, San Bernardino, California. Volume 1. Technical Report.

    Science.gov (United States)

    1985-07-01

    hydrocarbons (trans)l,2-dichlorethylene and trichloroethylene (TCE) in the 0.4 to 1.0 mg/l range, the solvent methyl ethyl ketone (MEK) at 0.043 mg/l...solutions, metal wastes, paint solutions, phenolic paint thinners and strippers, and solvents such as PD-680, toluene, methyl ethyl ketone (MEK) and...perese- grained thgo t Potn lirvr-btart ability, 2,000 to 3.000 gpd pee eq. rr. lad, andsrgna of Cea n adn Valloy. Uncap Upper meeter In places ie

  13. Shemya AFB, Alaska 1992 IRP field investigation report

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    The US Air Force is currently investigating 22 sites on Shemya Air Force Base (AFB) to determine if past spill and disposal activities have caused environmental damage. These investigations are being carried out under the Air Force's Installation Restoration Program (IRP). Field investigations were performed in 1992 to obtain the information needed to assess what future actions will need to be carried out at each site. The island's drinking water supply was also investigated. Activities completed at 10 selected sites included surface sampling to determine the lateral extent of contamination, subsurface sampling to determine the vertical extent of contamination, and the installation of well points and monitoring wells to determine the direction of groundwater flow and if the groundwater has been affected by a site. Geophysical surveys were performed at most sites to identify site boundaries and check for the presence of buried metal to be avoided during drilling activities. This report, appendices B, C, and D contains information on the following: geophysical contour maps and profile plots; human health risk assessment; and ecological risk assessment.

  14. Installation Restoration Program. Phase 2 - Confirmation/Quantification Stage 1. Dover Air Force Base, Dover, Delaware 19901. Volume 1 Technical Report

    Science.gov (United States)

    1986-06-10

    Include Security Clasification ) IRP Phase II, Stage 1, Dover AFB, DE 12 ’OERSONAL AUTHOR(S) Tokarski, E., J. Bramlett, R. Eades, A. Lanins. and E. Repa...Federal law and they have been adopted by Delaware. MCLs represent a calculated lifetime exposure level for a 154-pound adult consuming 0.5 gallons of

  15. The IRP/IRE system in vivo: insights from mouse models

    Directory of Open Access Journals (Sweden)

    Nicole eWilkinson

    2014-07-01

    Full Text Available Iron regulatory proteins 1 and 2 (IRP1 and IRP2 post-transcriptionally control the expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism. The mechanism involves their binding to iron responsive elements (IREs in the untranslated regions of target mRNAs, thereby controlling mRNA translation or stability. Whereas IRP2 functions solely as an RNA-binding protein, IRP1 operates as either an RNA-binding protein or a cytosolic aconitase. Early experiments in cultured cells established a crucial role of IRPs in regulation of cellular iron metabolism. More recently, studies in mouse models with global or localized Irp1 and/or Irp2 deficiencies uncovered new physiological functions of IRPs in the context of systemic iron homeostasis. Thus, IRP1 emerged as a key regulator of erythropoiesis and iron absorption by controlling hypoxia inducible factor 2α (HIF2α mRNA translation, while IRP2 appears to dominate the control of iron uptake and heme biosynthesis in erythroid progenitor cells by regulating the expression of transferrin receptor 1 (TfR1 and 5-aminolevulinic acid synthase 2 (ALAS2 mRNAs, respectively. Targeted disruption of either Irp1 or Irp2 in mice is associated with distinct phenotypic abnormalities. Thus, Irp1-/- mice develop polycythemia and pulmonary hypertension, while Irp2-/- mice present with microcytic anemia, iron overload in the intestine and the liver, and neurologic defects. Combined disruption of both Irp1 and Irp2 is incombatible with life and leads to early embryonic lethality. Mice with intestinal- or liver-specific disruption of both Irps are viable at birth but die later on due to malabsorption or liver failure, respectively. Adult mice lacking both Irps in the intestine exhibit a profound defect in dietary iron absorption due to a mucosal block that is caused by the de-repression of ferritin mRNA translation. Herein, we discuss the physiological function of the IRE/IRP regulatory system.

  16. Shemya AFB, Alaska 1992 IRP field investigation report. Volume 1: Final report

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    The US Air Force is currently investigating 22 sites on Shemya Air Force Base (AFB) to determine if past spill and disposal activities have caused environmental damage. These investigations are being carried out under the Air Force`s Installation Restoration Program (IRP). As a part of the IRP program, field investigations were performed in 1992 to obtain the information needed to assess what future actions willneed to be carried out at each site. The island`s drinking water supply was also investigated. Activities completed at 10 selected sites during the 1992 field investigation included surface sampling to determine the lateral extent of contamination, subsurface sampling to determine the vertical extent of contamination, and the installation of well points and monitoring wells to determine the direction of groundwater flow and if the groundwater has been affected by a site. In addition, geophysical surveys were performed at most sites to identify site boundaries and check for the presence of buried metal to be avoided during drilling activities.

  17. Road map to safety : the PSC, DACC and IRPs

    Energy Technology Data Exchange (ETDEWEB)

    Sunstrum, M. [Canadian Petroleum Safety Council, Calgary, AB (Canada)

    2003-07-01

    The Canadian Petroleum Safety Council works closely with industry and governments to develop safe, efficient and environmentally suitable operating practices. It is responsible for developing industry recommended practices (IRPs), guides to safe work (GTSW), safety alerts, and safety initiatives. The Council reviews outdated IRPs, particularly where new technology requires new operating procedures. The Upstream Petroleum Industry Task Force on Safety (UPITFOS) has published a document listing 41 recommendations. It includes a set of best practices and guidelines and is based on compiled data and experience from the industry. It is intended to provide operators with advice regarding specific topics such as heavy oil and oil sands operations; well testing and fluid handling; minimum wellhead requirements; pumping of flammable fluids; snubbing operations; surface casing vent flow; gas migration testing and repair; drilling critical sour wells; underbalanced drilling; drilling completions; workover fluids; casing designs; piping systems; and, coiled tubing. 2 figs.

  18. Tumorigenic properties of iron regulatory protein 2 (IRP2 mediated by its specific 73-amino acids insert.

    Directory of Open Access Journals (Sweden)

    Carmen Maffettone

    Full Text Available Iron regulatory proteins, IRP1 and IRP2, bind to mRNAs harboring iron responsive elements and control their expression. IRPs may also perform additional functions. Thus, IRP1 exhibited apparent tumor suppressor properties in a tumor xenograft model. Here we examined the effects of IRP2 in a similar setting. Human H1299 lung cancer cells or clones engineered for tetracycline-inducible expression of wild type IRP2, or the deletion mutant IRP2(Delta73 (lacking a specific insert of 73 amino acids, were injected subcutaneously into nude mice. The induction of IRP2 profoundly stimulated the growth of tumor xenografts, and this response was blunted by addition of tetracycline in the drinking water of the animals, to turnoff the IRP2 transgene. Interestingly, IRP2(Delta73 failed to promote tumor growth above control levels. As expected, xenografts expressing the IRP2 transgene exhibited high levels of transferrin receptor 1 (TfR1; however, the expression of other known IRP targets was not affected. Moreover, these xenografts manifested increased c-MYC levels and ERK1/2 phosphorylation. A microarray analysis identified distinct gene expression patterns between control and tumors containing IRP2 or IRP1 transgenes. By contrast, gene expression profiles of control and IRP2(Delta73-related tumors were more similar, consistently with their growth phenotype. Collectively, these data demonstrate an apparent pro-oncogenic activity of IRP2 that depends on its specific 73 amino acids insert, and provide further evidence for a link between IRPs and cancer biology.

  19. Progressive IRP Models for Power Resources Including EPP

    Directory of Open Access Journals (Sweden)

    Yiping Zhu

    2017-01-01

    Full Text Available In the view of optimizing regional power supply and demand, the paper makes effective planning scheduling of supply and demand side resources including energy efficiency power plant (EPP, to achieve the target of benefit, cost, and environmental constraints. In order to highlight the characteristics of different supply and demand resources in economic, environmental, and carbon constraints, three planning models with progressive constraints are constructed. Results of three models by the same example show that the best solutions to different models are different. The planning model including EPP has obvious advantages considering pollutant and carbon emission constraints, which confirms the advantages of low cost and emissions of EPP. The construction of progressive IRP models for power resources considering EPP has a certain reference value for guiding the planning and layout of EPP within other power resources and achieving cost and environmental objectives.

  20. IRP applied to district heating in Eastern Europe

    Energy Technology Data Exchange (ETDEWEB)

    Bull, M. [USDOE Bonneville Power Administration, Portland, OR (United States); Secrest, T. [Pacific Northwest Lab., Richland, WA (United States); Zeman, J. [Czech Energy Efficiency Center (SEVEn) (Czech Republic); Popelka, A. [TECOGEN, Inc., Waltham, MA (United States)

    1994-08-01

    The cities of Plzen, Czech Republic, and Handlova, Republic of Slovakia, are examining options for meeting the thermal energy requirements of their citizens with consideration of both economics and the environment. Major energy related issues faced by the cities are: the frequent need to replace and/or implement a major rehabilitation of the central heating plants and the transmission and distribution systems that supply the consumers; and the need to reduce emissions in order to comply with more stringent environmental regulations and improve air quality; and the need to minimize consumer energy bills, particularly to accommodate the upcoming decontrol of energy prices and to minimize non-payment problems. The intent of the integrated resource planning (IRP) projects is to present analyses of options to support the cities` decision-making processes, not to provide specific recommendations or guidance for the cities to follow.

  1. Mortgage Loan Portfolio Optimization Using Multi-Stage Stochastic Programming

    DEFF Research Database (Denmark)

    Rasmussen, Kourosh Marjani; Clausen, Jens

    2007-01-01

    We consider the dynamics of the Danish mortgage loan system and propose several models to reflect the choices of a mortgagor as well as his attitude towards risk. The models are formulated as multi stage stochastic integer programs, which are difficult to solve for more than 10 stages. Scenario...... reduction and LP relaxation are used to obtain near optimal solutions for large problem instances. Our results show that the standard Danish mortgagor should hold a more diversified portfolio of mortgage loans, and that he should rebalance the portfolio more frequently than current practice....

  2. The IRP management concept; Integrated resource planning (IRP) as a market-economy instrument of modern electric-utility management. Das IRP-Management-Konzept; Integrierte Ressourcenplanung (IRP) als marktwirtschaftliches Instrument einer modernen Unternehmensfuehrung fuer Elektrizitaetsversorgungsunternehmen (EVU)

    Energy Technology Data Exchange (ETDEWEB)

    Thiel, D. (Basel Univ. (Switzerland)); Breu, S. (HSG, Buelach (Switzerland))

    1994-05-13

    Least cost planning and demand side management concepts are currently discussed as one looks for ingenious solutions to the increase in electric power demands. The weak points of these concepts, i.e. rigorous governmental intervention in autonomous electric-utility management, and inefficiencies which result from governmental intervention, are done away with by applying an alternative market-oriented approach which makes the most of the electric utilities' management potential and which contributes to an effective energy policy. The approach consists of political and of economic elements. The political emphasis is on the reflection of the scarcity of supplies by tariffs and on a further increase in the electric utilities' economic efficiency by more competition. The solution's economic emphasis is on the application of a management concept which combines proven strategical-management and marketing approaches. The pure management approach is referred to as IRP for being related to the economic concept of integrated resource planning. (orig.)

  3. A probabilistic lower bound for two-stage stochastic programs

    Energy Technology Data Exchange (ETDEWEB)

    Dantzig, G.B.; Infanger, G.

    1995-11-01

    In the framework of Benders decomposition for two-stage stochastic linear programs, the authors estimate the coefficients and right-hand sides of the cutting planes using Monte Carlo sampling. The authors present a new theory for estimating a lower bound for the optimal objective value and they compare (using various test problems whose true optimal value is known) the predicted versus the observed rate of coverage of the optimal objective by the lower bound confidence interval.

  4. Validating an image segmentation program devised for staging lymphoma.

    Science.gov (United States)

    Slattery, Anthony

    2017-10-02

    Hybrid positron emission tomography-computed tomography (PET-CT) imaging systems are an important tool for assessing the progression of lymphoma. PET-CT systems offer the ability to quantitatively assess lymphocytic bone involvement throughout the body. There is no standard methodology for staging lymphoma patients using PET-CT images. Automatic image segmentation algorithms could offer medical specialists a means to evaluate bone involvement from PET-CT images in a consistent manner. To devise and validate an image segmentation program that may assist staging lymphoma by determining the degree of bone involvement based from PET-CT studies. A custom-made program was developed to segment regions-of-interest from images by utilising an enhanced fuzzy clustering technique that incorporates spatial information. The program was subsequently tested on digital and physical phantoms using four different performance metrics before being employed to extract the bony regions of clinical PET-CT images acquired from 248 patients staged for lymphoma. The algorithm was satisfactorily able to delineate regions-of-interest within all phantoms. When applied to the clinical PET-CT images, the algorithm was capable of accurately segmenting bony regions in less than half of the subjects (n = 103). The performance of the algorithm was adversely affected by the presence of oral contrast, metal implants and the poor image quality afforded by low dose CT images in general. Significant changes are necessary before the algorithm can be employed clinically in an unsupervised fashion. However, with further work performed, the algorithm could potentially prove useful for medical specialists staging lymphoma in the future.

  5. 77 FR 64755 - Medicare and Medicaid Programs; Electronic Health Record Incentive Program-Stage 2; Corrections

    Science.gov (United States)

    2012-10-23

    ... public comments regarding 2011 Edition of EHR certification criteria, we made a grammatical error. On... document corrects technical errors and typographical errors in the final rule entitled ``Medicare and... Programs; Electronic Health Record Incentive Program--Stage 2'' there were a number of technical errors and...

  6. Human Research Program Integrated Research Plan: December 20, 2007, Interim Baseline

    Science.gov (United States)

    2008-01-01

    The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. This Integrated Research Plan (IRP) describes the program s research activities that are intended to address the needs of human space exploration and serve HRP customers. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration. The document serves several purposes for the Human Research Program: The IRP provides a means to assure that the most significant risks to human space explorers are being adequately mitigated and/or addressed, The IRP shows the relationship of research activities to expected outcomes and need dates, The IRP shows the interrelationships among research activities that may interact to produce products that are integrative or cross defined research disciplines, The IRP illustrates the non-deterministic nature of research and technology activities by showing expected decision points and potential follow-on activities, The IRP shows the assignments of responsibility within the program organization and, as practical, the intended solicitation approach, The IRP shows the intended use of research platforms such as the International Space Station, NASA Space Radiation Laboratory, and various space flight analogs. The IRP does not show all budgeted activities of the Human research program, as some of these are enabling functions, such as management, facilities and infrastructure

  7. Hyper-X Stage Separation Wind Tunnel Test Program

    Science.gov (United States)

    Woods, W. C.; Holland, S. D.; DiFulvio, M.

    2000-01-01

    NASA's Hyper-X research program was developed primarily to flight demonstrate a supersonic combustion ramjet engine, fully integrated with a forebody designed to tailor inlet flow conditions and a free expansion nozzle/afterbody to produce positive thrust at design flight conditions. With a point-designed propulsion system, the vehicle must depend upon some other means for boost to its design flight condition. Clean separation from this initial propulsion system stage within less than a second is critical to the success of the flight. This paper discusses the early planning activity, background, and chronology that developed the series of wind tunnel tests to support multi degree of freedom simulation of the separation process. Representative results from each series of tests are presented and issues and concerns during the process and current status will be highlighted.

  8. Hyper-X Stage Separation Wind-Tunnel Test Program

    Science.gov (United States)

    Woods, William C.; Holland, Scott D.; DiFulvio, Michael

    2001-01-01

    NASA's Hyper-X research program was developed primarily to flight demonstrate a supersonic combustion ramjet engine, fully integrated with a forebody designed to tailor inlet flow conditions and a free expansion nozzle/afterbody to produce positive thrust at design flight conditions. With a point-designed propulsion system the vehicle must depend on some other means for boost to its design flight condition. Clean separation from this initial propulsion system stage within less than a second is critical to the success of the flight. This paper discusses the early planning activity, background, and chronology that developed the series of wind-tunnel tests to support multi-degree-of-freedom simulation of the separation process. Representative results from each series of tests are presented, and issues and concerns during the process and current status are highlighted.

  9. The impact of instant reward programs and bonus premiums on consumer purchase behavior

    NARCIS (Netherlands)

    Minnema, Alec; Bijmolt, Tammo H. A.; Non, Marielle C.

    This study examines the impact of an instant reward program (IRP) with bonus premiums on consumer purchase behavior. An IRP is a rapidly growing form of short-term program that rewards consumers instantly with small premiums per fixed spending, where these premiums are part of a larger set of

  10. Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice

    KAUST Repository

    Jeong, Suh Young

    2011-10-07

    Genetic ablation of Iron Regulatory Protein 2 (Irp2, Ireb2), which post-transcriptionally regulates iron metabolism genes, causes a gait disorder in mice that progresses to hind-limb paralysis. Here we have demonstrated that misregulation of iron metabolism from loss of Irp2 causes lower motor neuronal degeneration with significant spinal cord axonopathy. Mitochondria in the lumbar spinal cord showed significantly decreased Complex I and II activities, and abnormal morphology. Lower motor neurons appeared to be the most adversely affected neurons, and we show that functional iron starvation due to misregulation of iron import and storage proteins, including transferrin receptor 1 and ferritin, may have a causal role in disease. We demonstrated that two therapeutic approaches were beneficial for motor neuron survival. First, we activated a homologous protein, IRP1, by oral Tempol treatment and found that axons were partially spared from degeneration. Secondly, we genetically decreased expression of the iron storage protein, ferritin, to diminish functional iron starvation. These data suggest that functional iron deficiency may constitute a previously unrecognized molecular basis for degeneration of motor neurons in mice.

  11. Dysregulation of IRP1-mediated iron metabolism causes gamma ray-specific radioresistance in leukemia cells.

    Directory of Open Access Journals (Sweden)

    Kurtis J Haro

    Full Text Available Iron is required for nearly all organisms, playing important roles in oxygen transport and many enzymatic reactions. Excess iron, however, can be cytotoxic. Emerging evidence suggests that radioresistance can be achieved in lower organisms by the protection of proteins, but not DNA, immediately following ionizing radiation (IR exposure, allowing for improved DNA repair. One potential mechanism for protein protection is controlling and limiting the amount of free iron in cells, as has been demonstrated in the extremophile Deinococcus Radiodurans, reducing the potential for oxidative damage to proteins during exposure to IR. We found that iron regulatory protein 1 (IRP1 expression was markedly reduced in human myeloid leukemia HL60 cells resistant to low linear energy transfer (LET gamma rays, but not to high LET alpha particles. Stable knockdown of IRP1 by short-hairpin RNA (shRNA interference in radiosensitive parental cells led to radioresistance to low LET IR, reduced intracellular Fenton chemistry, reduced protein oxidation, and more rapid DNA double-strand break (DSB repair. The mechanism of radioresistance appeared to be related to attenuated free radical-mediated cell death. Control of intracellular iron by IRPs may be a novel radioresistance mechanism in mammalian cells.

  12. 10 CFR 905.11 - What must an IRP include?

    Science.gov (United States)

    2010-01-01

    ... renewable energy resources, to provide adequate and reliable service to a customer's electric consumers. An... accomplishment of those actions during implementation; and (C) Estimated energy and capacity benefits for each... techniques, renewable energy resources, and other programs; and (ii) Minimize, to the extent practical...

  13. Shemya AFB, Alaska 1992 IRP field investigation report. Volume 3, Appendixes B, C, and D: Final report

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    The US Air Force is currently investigating 22 sites on Shemya Air Force Base (AFB) to determine if past spill and disposal activities have caused environmental damage. These investigations are being carried out under the Air Force`s Installation Restoration Program (IRP). Field investigations were performed in 1992 to obtain the information needed to assess what future actions will need to be carried out at each site. The island`s drinking water supply was also investigated. Activities completed at 10 selected sites included surface sampling to determine the lateral extent of contamination, subsurface sampling to determine the vertical extent of contamination, and the installation of well points and monitoring wells to determine the direction of groundwater flow and if the groundwater has been affected by a site. Geophysical surveys were performed at most sites to identify site boundaries and check for the presence of buried metal to be avoided during drilling activities. This report, appendices B, C, and D contains information on the following: geophysical contour maps and profile plots; human health risk assessment; and ecological risk assessment.

  14. Desarrollo de un IRP en niños con Infección Urinaria Febril

    OpenAIRE

    Mondragón Cedeño, Stella Enriqueta

    2016-01-01

    Introducción: La infección del tracto urinario (ITU) es una infección bacteriana frecuente en niños, del 50% al 75% de los casos de ITU febril desarrollan pielonefritis. La pielonefritis es un factor de riesgo de lesión renal permanente, que se puede asociar en la vida adulta a hipertensión arterial, disminución de la tasa de filtración glomerular, proteinuria y complicaciones durante la gestación. Objetivo: Construimos un Índice de Riesgo de Pielonefritis (IRP) en niños entre 1 mes y 2 año...

  15. Decomposition and (importance) sampling techniques for multi-stage stochastic linear programs

    Energy Technology Data Exchange (ETDEWEB)

    Infanger, G.

    1993-11-01

    The difficulty of solving large-scale multi-stage stochastic linear programs arises from the sheer number of scenarios associated with numerous stochastic parameters. The number of scenarios grows exponentially with the number of stages and problems get easily out of hand even for very moderate numbers of stochastic parameters per stage. Our method combines dual (Benders) decomposition with Monte Carlo sampling techniques. We employ importance sampling to efficiently obtain accurate estimates of both expected future costs and gradients and right-hand sides of cuts. The method enables us to solve practical large-scale problems with many stages and numerous stochastic parameters per stage. We discuss the theory of sharing and adjusting cuts between different scenarios in a stage. We derive probabilistic lower and upper bounds, where we use importance path sampling for the upper bound estimation. Initial numerical results turned out to be promising.

  16. The irp2 and fyuA genes in High Pathogenicity Islands are involved in the pathogenesis of infections caused by avian pathogenic Escherichia coli (APEC).

    Science.gov (United States)

    Tu, Jian; Xue, Ting; Qi, Kezong; Shao, Ying; Huang, Boyan; Wang, Xueyan; Zhou, Xiuhong

    2016-01-01

    Avian pathogenic Escherichia coli (APEC) is a major bacterial infectious disease that may lead to local or systemic infections in chickens with clinical manifestations. The irp2-fyuA gene cluster has been confirmed to be the main genes involved in the synthesis of HPI. The objective of this study was to determine the influence of the irp2 and fyuA genes in the high pathogenicity island (HPI) of avian pathogenic Escherichia coli (APEC) on its pathogenicity by knocking out these genes. The ΔAE17 (lacking irp2) and ΔΔAE17 (lacking irp2 and fyuA) strains of APEC were constructed. The ΔAE17 and ΔΔAE17 strains showed significantly impaired capacity to adhere onto DF-1 cells. The LD50 results indicated that the virulence of the ΔAE17 and ΔΔAE17 strains was decreased in comparison with that of the AE17 strain. We concluded that the knock-out of the core HPI genes weakened APEC adhesion onto DF-1 cells, inhibited transcription of virulence genes, and reduced pathogenicity in chicks. The effects of genetic deletion of irp2 and fyuA on APEC were more severe than those produced by deletion of irp2 only, indicating that irp2 and fyuA co-regulate APEC pathogenicity.

  17. Installation Restoration Program Phase 2 - Confirmation/Quantification Stage 1 for Air Force Plant PJKS, Waterton, Colorado. Volume 1

    Science.gov (United States)

    1986-10-06

    SUPPLEMENTARY NOTATON .7. coos 1. SUIJECT TERMS (Copw,. an oirem i ,,eceuafy and ientity by block numb" FIELO GROUP su-Goup IRP Contaminacion Hazardous Waste...1980a. Ambient Water Quality Criteria for Nitrosaimes. EPA No. 440/5-80-064. U.S. Environmental Protection Agency. 1980b. Ambient Water Criteria for

  18. Cardiac Rehabilitation Program in Improving Cardiorespiratory Fitness in Stage 0-III Breast Cancer Survivors

    Science.gov (United States)

    2017-08-17

    Cancer Survivor; Stage 0 Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer

  19. Historical Research Skills Development in Light of a Training Program for Secondary Stage History Teachers

    Science.gov (United States)

    Al-qout, Ghada Ahmed

    2017-01-01

    The study aimed to design a training program to develop the historical research skills after defining the nature of the historical research skills that the history teachers are required to master, especially the secondary stage teachers, in addition to defining the opinions of the educational supervisors on the extent to which the secondary…

  20. A two-stage stochastic programming approach for operating multi-energy systems

    DEFF Research Database (Denmark)

    Zeng, Qing; Fang, Jiakun; Chen, Zhe

    2017-01-01

    This paper provides a two-stage stochastic programming approach for joint operating multi-energy systems under uncertainty. Simulation is carried out in a test system to demonstrate the feasibility and efficiency of the proposed approach. The test energy system includes a gas subsystem with a gas...

  1. An experimental program for physical education of rugby players at the stage of specialized basic training

    Directory of Open Access Journals (Sweden)

    Artur Martyrosyan

    2017-06-01

    Full Text Available Purpose: to develop a program of general physical training of rugby players at the stage of specialized basic training and to investigate the dynamics of indicators of general physical preparedness using computer technology. Material & Methods: study involved 60 athletes aged 16-18 years. Results: content of the comprehensive program of general physical training of rugby athletes at the stage of specialized basic training and the results of an experimental verification of its implementation are presented. Conclusion: in the course of the pedagogical experiment, the effectiveness of using the developed experimental program for improving the training process of rugby players of 16-18 years is proved, which is confirmed by the results of the research.

  2. Installation Restoration Program (IRP) for IRP Sites Numbers 4, 5, 7 and 14. 152 Tactical Reconnaissance Group, Nevada Air National Guard, Reno Tahoe International Airport, Reno, Nevada

    Science.gov (United States)

    1996-01-01

    daily temperature change is 35°F with a maximum daily temperature change of 43.51F occurring in July and August (ASG, 1909). National Oceanic and...272 a9.5 . [4-~ ~~~~ ~~ Flam P af1.i1 F -t ’I In lrit . i ri1,ri -56 Ii a-Flu 4 0 1. 2 1 C- UtIrLflowdr 4 .4 OAK- -Un- z o. lr sck orl 4 Ist~t _4 ’j .t

  3. Functionality of the approach of hierarchical analysis in the full cost accounting in the IRP of a metropolitan airport

    Energy Technology Data Exchange (ETDEWEB)

    Cicone, Decio Jr. [GEPEA-USP, Grupo de Energia do Departamento de Engenharia de Energia e Automacao Eletricas, Escola Politecnica da Universidade de Sao Paulo (Brazil); Udaeta, Miguel Edgar Morales; Grimoni, Jose Aquiles Baesso; Galvao, Luiz Claudio Ribeiro [IEE/USP, Instituto de Eletrotecnica e Energia, Universidade de Sao Paulo (Brazil)

    2008-03-15

    This work shows the application of the analytic hierarchy process (AHP) in the full cost accounting (FCA) within the integrated resource planning (IRP) process. For this purpose, a pioneer case was developed and different energy solutions of supply and demand for a metropolitan airport (Congonhas) were considered [Moreira, E.M., 2005. Modelamento energetico para o desenvolvimento limpo de aeroporto metropolitano baseado na filosofia do PIR - O caso da metropole de Sao Paulo. Dissertacao de mestrado, GEPEA/USP]. These solutions were compared and analyzed utilizing the software solution ''Decision Lens'' that implements the AHP. The final part of this work has a classification of resources that can be considered to be the initial target as energy resources, thus facilitating the restraints of the IRP of the airport and setting parameters aiming at sustainable development. (author)

  4. A two-stage sequential linear programming approach to IMRT dose optimization

    Science.gov (United States)

    Zhang, Hao H; Meyer, Robert R; Wu, Jianzhou; Naqvi, Shahid A; Shi, Leyuan; D’Souza, Warren D

    2010-01-01

    The conventional IMRT planning process involves two stages in which the first stage consists of fast but approximate idealized pencil beam dose calculations and dose optimization and the second stage consists of discretization of the intensity maps followed by intensity map segmentation and a more accurate final dose calculation corresponding to physical beam apertures. Consequently, there can be differences between the presumed dose distribution corresponding to pencil beam calculations and optimization and a more accurately computed dose distribution corresponding to beam segments that takes into account collimator-specific effects. IMRT optimization is computationally expensive and has therefore led to the use of heuristic (e.g., simulated annealing and genetic algorithms) approaches that do not encompass a global view of the solution space. We modify the traditional two-stage IMRT optimization process by augmenting the second stage via an accurate Monte-Carlo based kernel-superposition dose calculations corresponding to beam apertures combined with an exact mathematical programming based sequential optimization approach that uses linear programming (SLP). Our approach was tested on three challenging clinical test cases with multileaf collimator constraints corresponding to two vendors. We compared our approach to the conventional IMRT planning approach, a direct-aperture approach and a segment weight optimization approach. Our results in all three cases indicate that the SLP approach outperformed the other approaches, achieving superior critical structure sparing. Convergence of our approach is also demonstrated. Finally, our approach has also been integrated with a commercial treatment planning system and may be utilized clinically. PMID:20071764

  5. The training program in basic gymnastics jumps at the stage of initial training

    Directory of Open Access Journals (Sweden)

    Oksana Zaplatynska

    2015-08-01

    Full Text Available Purpose: improving of the technical training of girls that are engaged in rhythmic gymnastics at the stage of initial training. Materials and Methods: for the development of a training program for jumping in athletes who are engaged in rhythmic gymnastics at the stage of initial training conducted analysis of scientific literature. Results: it was determined that the absorption of the rhythmic structure of elements greatly accelerates and facilitates the process of studying in a cyclic (athletics and acyclic sports (judo, wrestling. This is a prerequisite for the development of the training program of the jumps through assimilation rates their performance. These various methods of influence on the development of sense of rhythmic gymnasts at the stage of initial preparation and learning the rhythmic structure of the basic jumps. Conclusions: the program of teaching basic jumping for gymnasts at the stage of initial training, a variety of methods of influence on the development of sense of rhythm and learning the rhythmic structure of the elements was developed. The project of the training session for the development of a sense of rhythm and learning the rhythmic structure of the basic jumps was developed.

  6. Combined Two-Stage Stochastic Programming and Receding Horizon Control Strategy for Microgrid Energy Management Considering Uncertainty

    National Research Council Canada - National Science Library

    Li, Zhongwen; Zang, Chuanzhi; Zeng, Peng; Yu, Haibin

    2016-01-01

    .... In this paper, a combined stochastic programming and receding horizon control (SPRHC) strategy is proposed for microgrid energy management under uncertainty, which combines the advantages of two-stage stochastic programming (SP...

  7. Hill AFB, Utah Installation Restoration Program. Phase IIB, IRP Survey. Volume 1. Text. Volume 2. Appendices

    Science.gov (United States)

    1984-09-11

    Octadecane 0.5-2 Nonadecane 1-4 Eicosane 1-4 Heneicosane 0.5-2 Phytane 0.5-2 Paraffin oil C2 0 -C4 0 250-1000 ICP Analysis (milligrams per liter...5-20 Decane 1-4 Hexadecane 1-4 Heptadecane 0.5-2 Pristane 0.5-2 *Octadecane 1-4 * Phytane 0.*5-2 *Nonadecane 2-6 Eicosane 1-4 Reneicosane 1-4 Paraffin...substituted benzenes 2-8 3-10 Styrene 5-20- Alkyl benzenes 5-20 4-16 Hexadecane 2-6 Octadecane 0.5-2 Nonadecane 1-4 Eicosane 1-4 Heneicosane 0.5-2 Phytane 0.5-2

  8. 77 FR 13697 - Medicare and Medicaid Programs; Electronic Health Record Incentive Program-Stage 2

    Science.gov (United States)

    2012-03-07

    ... hospitals, and CAHs failing to demonstrate meaningful use of certified EHR technology and other program... (certified EHR technology) CAH--Critical Access Hospital CAHPS--Consumer Assessment of Healthcare Providers... Clinical Quality Measures Using Certified EHRs Technology by Eligible Professionals, Eligible Hospitals...

  9. FitKids360: Design, Conduct, and Outcomes of a Stage 2 Pediatric Obesity Program

    Directory of Open Access Journals (Sweden)

    Jared M. Tucker

    2014-01-01

    Full Text Available This paper describes FitKids360, a stage 2 pediatric weight management program. FitKids360 is a physician-referred, multicomponent, low-cost healthy lifestyle program for overweight and obese youth 5–16 years of age and their families. FitKids360 provides an evidence-based approach to the treatment of pediatric overweight by targeting patients’ physical activity, screen time, and dietary behaviors using a family-centered approach. The intervention begins with a two-hour orientation and assessment period followed by six weekly sessions. Assessments include lifestyle behaviors, anthropometry, and the Family Nutrition and Physical Activity (FNPA survey, which screens for obesogenic risk factors in the home environment. Outcomes are presented from 258 patients who completed one of 33 FitKids360 classes. After completing FitKids360, patients increased moderate to vigorous physical activity by 14 minutes (P=0.019, reduced screen time by 44 minutes (P<0.001, and improved key dietary behaviors. Overall, FNPA scores increased by 9% (P<0.001 and 69% of patients with “high risk” FNPA scores at baseline dropped below the “high risk” range by followup. Patients also lowered BMIs (P=0.011 and age- and sex-adjusted BMI z-scores (P<0.001 after completing the 7-week program. We hope this report will be useful to medical and public health professionals seeking to develop stage 2 pediatric obesity programs.

  10. A two-stage inexact joint-probabilistic programming method for air quality management under uncertainty.

    Science.gov (United States)

    Lv, Y; Huang, G H; Li, Y P; Yang, Z F; Sun, W

    2011-03-01

    A two-stage inexact joint-probabilistic programming (TIJP) method is developed for planning a regional air quality management system with multiple pollutants and multiple sources. The TIJP method incorporates the techniques of two-stage stochastic programming, joint-probabilistic constraint programming and interval mathematical programming, where uncertainties expressed as probability distributions and interval values can be addressed. Moreover, it can not only examine the risk of violating joint-probability constraints, but also account for economic penalties as corrective measures against any infeasibility. The developed TIJP method is applied to a case study of a regional air pollution control problem, where the air quality index (AQI) is introduced for evaluation of the integrated air quality management system associated with multiple pollutants. The joint-probability exists in the environmental constraints for AQI, such that individual probabilistic constraints for each pollutant can be efficiently incorporated within the TIJP model. The results indicate that useful solutions for air quality management practices have been generated; they can help decision makers to identify desired pollution abatement strategies with minimized system cost and maximized environmental efficiency. Copyright © 2010 Elsevier Ltd. All rights reserved.

  11. The iron-responsive element (IRE)/iron-regulatory protein 1 (IRP1)–cytosolic aconitase iron-regulatory switch does not operate in plants

    Science.gov (United States)

    Arnaud, Nicolas; Ravet, Karl; Borlotti, Andrea; Touraine, Brigitte; Boucherez, Jossia; Fizames, Cécile; Briat, Jean-François; Cellier, Françoise; Gaymard, Frédéric

    2007-01-01

    Animal cytosolic ACO (aconitase) and bacteria ACO are able to switch to RNA-binding proteins [IRPs (iron-regulatory proteins)], thereby playing a key role in the regulation of iron homoeostasis. In the model plant Arabidopsis thaliana, we have identified three IRP1 homologues, named ACO1–3. To determine whether or not they may encode functional IRP proteins and regulate iron homoeostasis in plants, we have isolated loss-of-function mutants in the three genes. The aco1-1 and aco3-1 mutants show a clear decrease in cytosolic ACO activity. However, none of the mutants is affected in respect of the accumulation of the ferritin transcript or protein in response to iron excess. cis-acting elements potentially able to bind to the IRP have been searched for in silico in the Arabidopsis genome. They appear to be very rare sequences, found in the 5′-UTR (5′-untranslated region) or 3′-UTR of a few genes unrelated to iron metabolism. They are therefore unlikely to play a functional role in the regulation of iron homoeostasis. Taken together, our results demonstrate that, in plants, the cytosolic ACO is not converted into an IRP and does not regulate iron homoeostasis. In contrast with animals, the RNA binding activity of plant ACO, if any, would be more likely to be attributable to a structural element, rather than to a canonical sequence. PMID:17437406

  12. NASA Ares I Launch Vehicle First Stage Roll Control System Cold Flow Development Test Program Overview

    Science.gov (United States)

    Butt, Adam; Popp, Christopher G.; Holt, Kimberly A.; Pitts, Hank M.

    2010-01-01

    The Ares I launch vehicle is the selected design, chosen to return humans to the moon, Mars, and beyond. It is configured in two inline stages: the First Stage is a Space Shuttle derived five-segment Solid Rocket Booster and the Upper Stage is powered by a Saturn V derived J-2X engine. During launch, roll control for the First Stage (FS) is handled by a dedicated Roll Control System (RoCS) located on the connecting Interstage. That system will provide the Ares I with the ability to counteract induced roll torque while any induced yaw or pitch moments are handled by vectoring of the booster nozzle. This paper provides an overview of NASA s Ares I FS RoCS cold flow development test program including detailed test objectives, types of tests run to meet those objectives, an overview of the results, and applicable lessons learned. The test article was built and tested at the NASA Marshall Space Flight Center in Huntsville, AL. The FS RoCS System Development Test Article (SDTA) is a full scale, flight representative water flow test article whose primary objective was to obtain fluid system performance data to evaluate integrated system level performance characteristics and verify analytical models. Development testing and model correlation was deemed necessary as there is little historical precedent for similar large flow, pulsing systems such as the FS RoCS. The cold flow development test program consisted of flight-similar tanks, pressure regulators, and thruster valves, as well as plumbing simulating flight geometries, combined with other facility grade components and structure. Orifices downstream of the thruster valves were used to simulate the pressure drop through the thrusters. Additional primary objectives of this test program were to: evaluate system surge pressure (waterhammer) characteristics due to thruster valve operation over a range of mission duty cycles at various feed system pressures, evaluate temperature transients and heat transfer in the

  13. Technical efficiency of women's health prevention programs in Bucaramanga, Colombia: a four-stage analysis.

    Science.gov (United States)

    Ruiz-Rodriguez, Myriam; Rodriguez-Villamizar, Laura A; Heredia-Pi, Ileana

    2016-10-13

    Primary Health Care (PHC) is an efficient strategy to improve health outcomes in populations. Nevertheless, studies of technical efficiency in health care have focused on hospitals, with very little on primary health care centers. The objective of the present study was to use the Data Envelopment Analysis to estimate the technical efficiency of three women's health promotion and disease prevention programs offered by primary care centers in Bucaramanga, Colombia. Efficiency was measured using a four-stage data envelopment analysis with a series of Tobit regressions to account for the effect of quality outcomes and context variables. Input/output information was collected from the institutions' records, chart reviews and personal interviews. Information about contextual variables was obtained from databases from the primary health program in the municipality. A jackknife analysis was used to assess the robustness of the results. The analysis was based on data from 21 public primary health care centers. The average efficiency scores, after adjusting for quality and context, were 92.4 %, 97.5 % and 86.2 % for the antenatal care (ANC), early detection of cervical cancer (EDCC) and family planning (FP) programs, respectively. On each program, 12 of the 21 (57.1 %) health centers were found to be technically efficient; having had the best-practice frontiers. Adjusting for context variables changed the scores and reference rankings of the three programs offered by the health centers. The performance of the women's health prevention programs offered by the centers was found to be heterogeneous. Adjusting for context and health care quality variables had a significant effect on the technical efficiency scores and ranking. The results can serve as a guide to strengthen management and organizational and planning processes related to local primary care services operating within a market-based model such as the one in Colombia.

  14. Association of pro-inflammatory cytokines and iron regulatory protein 2 (IRP2 with Leishmania burden in canine visceral leishmaniasis.

    Directory of Open Access Journals (Sweden)

    Paulo Ricardo Porfírio do Nascimento

    Full Text Available Leishmania infantum infection in humans and dogs can evolve with a wide range of clinical presentations, varying from asymptomatic infections to visceral leishmaniasis. We hypothesized that the immune response elicited by L. infantum infection could modulate whether the host will remain asymptomatic or progress to disease. A total of 44 dogs naturally infected with L. infantum were studied. Leishmania burden was estimated in the blood and spleen by qPCR. The expression of IFN-γ, TNF-α, IL-10 and Iron Regulatory Protein 2 (IRP2 were determined in the spleen by quantitative PCR. Sera cytokines were evaluated by ELISA. Dogs were grouped in quartiles according parasite burden. Increased expression of IFN-γ and TNF-α was associated with reduced Leishmania burden, whereas increased IL-10 and IRP2 expressions were associated with higher Leishmania load. Increased plasma albumin and IFN-γ expression explained 22.8% of the decrease in parasite burden in the spleen. These data confirm that lower IFN-γ response and higher IL-10 correlated with increased parasite load and severity of the visceral leishmaniasis in dogs. The balance between the branches of immune response and the intracellular iron availability could determine, in part, the course of Leishmania infection.

  15. Identification of epilepsy stages from ECoG using genetic programming classifiers.

    Science.gov (United States)

    Sotelo, Arturo; Guijarro, Enrique; Trujillo, Leonardo; Coria, Luis N; Martínez, Yuliana

    2013-11-01

    Epilepsy is a common neurological disorder, for which a great deal of research has been devoted to analyze and characterize brain activity during seizures. While this can be done by a human expert, automatic methods still lag behind. This paper analyzes neural activity captured with Electrocorticogram (ECoG), recorded through intracranial implants from Kindling model test subjects. The goal is to automatically identify the main seizure stages: Pre-Ictal, Ictal and Post-Ictal. While visually differentiating each stage can be done by an expert if the complete time-series is available, the goal here is to automatically identify the corresponding stage of short signal segments. The proposal is to pose the above task as a supervised classification problem and derive a mapping function that classifies each signal segment. Given the complexity of the signal patterns, it is difficult to a priori choose any particular classifier. Therefore, Genetic Programming (GP), a population based meta-heuristic for automatic program induction, is used to automatically search for the mapping functions. Two GP-based classifiers are used and extensively evaluated. The signals from epileptic seizures are obtained using the Kindling model of elicited epilepsy in rodent test subjects, for which a seizure was elicited and recorded on four separate days. Results show that signal segments from a single seizure can be used to derive accurate classifiers that generalize when tested on different signals from the same subject; i.e., GP can automatically produce accurate mapping functions for intra-subject classification. A large number of experiments are performed with the GP classifiers achieving good performance based on standard performance metrics. Moreover, a proof-of-concept real-world prototype is presented, where a GP classifier is transferred and hard-coded on an embedded system using a digital-to-analogue converter and a field programmable gate array, achieving a low average

  16. Suicide Prevention among High School Students: Evaluation of a Nonrandomized Trial of a Multi-Stage Suicide Screening Program

    Science.gov (United States)

    Torcasso, Gina; Hilt, Lori M.

    2017-01-01

    Background: Suicide is a leading cause of death among youth. Suicide screening programs aim to identify mental health issues and prevent death by suicide. Objective: The present study evaluated outcomes of a multi-stage screening program implemented over 3 school years in a moderately-sized Midwestern high school. Methods: One hundred ninety-three…

  17. Global Dynamic Transcriptome Programming of Rapeseed (Brassica napus L. Anther at Different Development Stages.

    Directory of Open Access Journals (Sweden)

    Zhanjie Li

    Full Text Available Rapeseed (Brassica napus L. is an important oil crop worldwide and exhibits significant heterosis. Effective pollination control systems, which are closely linked to anther development, are a prerequisite for utilizing heterosis. The anther, which is the male organ in flowering plants, undergoes many metabolic processes during development. Although the gene expression patterns underlying pollen development are well studied in model plant Arabidopsis, the regulatory networks of genome-wide gene expression during rapeseed anther development is poorly understood, especially regarding metabolic regulations. In this study, we systematically analyzed metabolic processes occurring during anther development in rapeseed using ultrastructural observation and global transcriptome analysis. Anther ultrastructure exhibited that numerous cellular organelles abundant with metabolic materials, such as elaioplast, tapetosomes, plastids (containing starch deposits etc. appeared, accompanied with anther structural alterations during anther development, suggesting many metabolic processes occurring. Global transcriptome analysis revealed dynamic changes in gene expression during anther development that corresponded to dynamic functional alterations between early and late anther developmental stages. The early stage anthers preferentially expressed genes involved in lipid metabolism that are related to pollen extine formation as well as elaioplast and tapetosome biosynthesis, whereas the late stage anthers expressed genes associated with carbohydrate metabolism to form pollen intine and to accumulate starch in mature pollen grains. Finally, a predictive gene regulatory module responsible for early pollen extine formation was generated. Taken together, this analysis provides a comprehensive understanding of dynamic gene expression programming of metabolic processes in the rapeseed anther, especially with respect to lipid and carbohydrate metabolism during pollen

  18. An inexact mixed risk-aversion two-stage stochastic programming model for water resources management under uncertainty.

    Science.gov (United States)

    Li, W; Wang, B; Xie, Y L; Huang, G H; Liu, L

    2015-02-01

    Uncertainties exist in the water resources system, while traditional two-stage stochastic programming is risk-neutral and compares the random variables (e.g., total benefit) to identify the best decisions. To deal with the risk issues, a risk-aversion inexact two-stage stochastic programming model is developed for water resources management under uncertainty. The model was a hybrid methodology of interval-parameter programming, conditional value-at-risk measure, and a general two-stage stochastic programming framework. The method extends on the traditional two-stage stochastic programming method by enabling uncertainties presented as probability density functions and discrete intervals to be effectively incorporated within the optimization framework. It could not only provide information on the benefits of the allocation plan to the decision makers but also measure the extreme expected loss on the second-stage penalty cost. The developed model was applied to a hypothetical case of water resources management. Results showed that that could help managers generate feasible and balanced risk-aversion allocation plans, and analyze the trade-offs between system stability and economy.

  19. A Risk-Based Interval Two-Stage Programming Model for Agricultural System Management under Uncertainty

    Directory of Open Access Journals (Sweden)

    Ye Xu

    2016-01-01

    Full Text Available Nonpoint source (NPS pollution caused by agricultural activities is main reason that water quality in watershed becomes worse, even leading to deterioration. Moreover, pollution control is accompanied with revenue’s fall for agricultural system. How to design and generate a cost-effective and environmentally friendly agricultural production pattern is a critical issue for local managers. In this study, a risk-based interval two-stage programming model (RBITSP was developed. Compared to general ITSP model, significant contribution made by RBITSP model was that it emphasized importance of financial risk under various probabilistic levels, rather than only being concentrated on expected economic benefit, where risk is expressed as the probability of not meeting target profit under each individual scenario realization. This way effectively avoided solutions’ inaccuracy caused by traditional expected objective function and generated a variety of solutions through adjusting weight coefficients, which reflected trade-off between system economy and reliability. A case study of agricultural production management with the Tai Lake watershed was used to demonstrate superiority of proposed model. Obtained results could be a base for designing land-structure adjustment patterns and farmland retirement schemes and realizing balance of system benefit, system-failure risk, and water-body protection.

  20. A Computer Program to Calculate Two-Stage Short-Run Control Chart Factors for (X,MR Charts

    Directory of Open Access Journals (Sweden)

    Matthew E. Elam

    2006-04-01

    Full Text Available This paper is the second in a series of two papers that fully develops two-stage short-run (X, MR control charts. This paper describes the development and execution of a computer program that accurately calculates first- and second-stage short-run control chart factors for (X, MR charts using the equations derived in the first paper. The software used is Mathcad. The program accepts values for number of subgroups, α for the X chart, and α for the MR chart both above the upper control limit and below the lower control limit. Tables are generated for specific values of these inputs and the implications of the results are discussed. A numerical example illustrates the use of the program.

  1. A comparative analysis of breast cancer stage between women enrolled in the National Breast and Cervical Cancer Early Detection Program and women not participating in the program.

    Science.gov (United States)

    Wu, Manxia; Austin, Harland; Eheman, Christie R; Myles, Zachary; Miller, Jacqueline; Royalty, Janet; Ryerson, A Blythe

    2015-05-01

    To determine the proportional distribution of early- and late-stage breast cancers diagnosed in years 2004-2009 among women enrolled in the National Breast and Cervical Cancer Early Detection Program (NBCCEDP) and to compare this distribution to that of geographically comparable non-enrolled women diagnosed with breast cancer. Using data from the National Program of Cancer Registries, we compared the demographic characteristics and cancer stage distribution of women enrollees and non-enrollees by use of conditional logistic regression using the odds ratio as a measure of association. NBCCEDP enrollees were slightly younger and more likely to identify as African-American, API and AIAN than were non-enrollees. The proportion of late-stage breast cancer (regional and distant) decreased slightly over the study period. NBCCEDP enrollees generally were diagnosed at a later stage of breast cancer than were those not enrolled in the NBCCEDP. The NBCCEDP has been effective in achieving its goal of enrolling racial and ethnic populations; however, enrollees had a poorer stage distribution of breast cancer than did non-enrollees underscoring the need to expand breast cancer control efforts among low-income, underserved populations.

  2. Medicare Program; End-Stage Renal Disease Prospective Payment System, Payment for Renal Dialysis Services Furnished to Individuals With Acute Kidney Injury, and End-Stage Renal Disease Quality Incentive Program. Final rule.

    Science.gov (United States)

    2017-11-01

    This rule updates and makes revisions to the end-stage renal disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2018. It also updates the payment rate for renal dialysis services furnished by an ESRD facility to individuals with acute kidney injury (AKI). This rule also sets forth requirements for the ESRD Quality Incentive Program (QIP), including for payment years (PYs) 2019 through 2021.

  3. Latent class analysis of stages of change for multiple health behaviors: results from the Special Diabetes Program for Indians Diabetes Prevention Program.

    Science.gov (United States)

    Jiang, Luohua; Beals, Janette; Zhang, Lijing; Mitchell, Christina M; Manson, Spero M; Acton, Kelly J; Roubideaux, Yvette

    2012-10-01

    This study sought to identify latent subgroups among American Indian and Alaska Native (AI/AN) patients with pre-diabetes based on their stages of change for multiple health behaviors. We analyzed baseline data from participants of the Special Diabetes Program for Indians Diabetes Prevention (SDPI-DP) Program, a lifestyle intervention program to prevent diabetes among AI/ANs. A total of 3,135 participants completed baseline questionnaires assessing stages of change for multiple health behaviors, specifically exercise, healthy eating, and weight loss. Latent class analysis was used to identify subgroups of people based on their answers to stages of change questions. Covariates were added to the latent class analyses to investigate how class membership was related to sociodemographic, behavioral, and psychosocial factors. Three classes were identified based on the distributions of the stages of change variables: Contemplation, Preparation, and Action/Maintenance classes. Male and retired participants were more likely to be in more advanced stages. Those who exercised more, ate healthier diets, and weighed less were significantly more likely to be in the Action/Maintenance class. Further, the participants who had higher self-efficacy, stronger family support, and better health-related quality of life had higher odds of being in the Action/Maintenance class. In conclusion, we found that stages of change for multiple behaviors can be summarized by a three-class model in this sample. Investigating the relationships between latent classes and intervention outcomes represents important next steps to extend the findings of the current study.

  4. Society for Vascular Surgery limb stage and patient risk correlate with outcomes in an amputation prevention program.

    Science.gov (United States)

    Causey, Marlin W; Ahmed, Ayman; Wu, Bian; Gasper, Warren J; Reyzelman, Alex; Vartanian, Shant M; Hiramoto, Jade S; Conte, Michael S

    2016-06-01

    Clinical decision making and accurate outcomes comparisons in advanced limb ischemia require improved staging systems. The Society for Vascular Surgery Lower Extremity Threatened Limb Classification System (Wound extent, Ischemia, and foot Infection [WIfI]) was designed to stratify limb outcomes based on three major factors-wound extent, ischemia, and foot infection. The Project or Ex-Vivo vein graft Engineering via Transfection III (PREVENT) III (PIII) risk score was developed to stratify patients by expected amputation-free survival (AFS) after surgical revascularization. This study was designed to prospectively assess limb and patient-based staging for predicting outcomes of hospitalized patients in an amputation prevention program. This study undertook a retrospective analysis of prospectively gathered registry data of consecutive patients with limb-threatening conditions admitted to a fully integrated vascular/podiatry service over a 16-month period. Upon admission, limb risk was stratified using the WIfI system and patient risk was categorized using PIII classification. Patients were assessed for perioperative and postdischarge outcomes, and their relationship to staging at admission was analyzed. There were 174 threatened limbs (143 hospitalized patients) stratified by WIfI stage (1%-12%, 2%-28%, 3%-24%, 4%-28%, 5%-3%, unstaged-5%) and PIII risk (34% low, 49% moderate, and 17% high risk). Diabetes and end-stage renal disease were associated with WIfI stage (P = .006 and P = .018) and PIII risk (P = .003 and P amputation. There were 119 limbs (71%) that underwent revascularization, including 108 infrainguinal reconstructions (endovascular or open revascularization). Rate of revascularization increased with WIfI stage (P procedures, minor amputations, and initial hospital duration of stay (all P procedures, there was a similar distribution of endovascular (46%) and surgical (54%) interventions. Freedom from major adverse limb events was best for

  5. Installation Restoration Program. Phase 2. Confirmation, Edwards AFB, California

    Science.gov (United States)

    1982-09-01

    to divert groundwater movement. IRP. Installation Restoration Program kg. Kilogram Lenticular. Having the shape of a lentil or double convex lense...California. Supervisor, Chemistry- Nutrition Laboratory. Responsible for operation of nutrient analysis facility for major food processing company. Developed...areas. Conducted lab- * oratory investigation of leachate composition and analysis of treatment techniques for application to leachates generated

  6. A Three-Stage Birandom Program for Unit Commitment with Wind Power Uncertainty

    Science.gov (United States)

    Zhang, Na; Li, Weidong; Liu, Rao; Lv, Quan; Sun, Liang

    2014-01-01

    The integration of large-scale wind power adds a significant uncertainty to power system planning and operating. The wind forecast error is decreased with the forecast horizon, particularly when it is from one day to several hours ahead. Integrating intraday unit commitment (UC) adjustment process based on updated ultra-short term wind forecast information is one way to improve the dispatching results. A novel three-stage UC decision method, in which the day-ahead UC decisions are determined in the first stage, the intraday UC adjustment decisions of subfast start units are determined in the second stage, and the UC decisions of fast-start units and dispatching decisions are determined in the third stage is presented. Accordingly, a three-stage birandom UC model is presented, in which the intraday hours-ahead forecasted wind power is formulated as a birandom variable, and the intraday UC adjustment event is formulated as a birandom event. The equilibrium chance constraint is employed to ensure the reliability requirement. A birandom simulation based hybrid genetic algorithm is designed to solve the proposed model. Some computational results indicate that the proposed model provides UC decisions with lower expected total costs. PMID:24987739

  7. Comparison of CFD-calculations of centrifugal compressor stages by NUMECA Fine Turbo and ANSYS CFX programs

    Science.gov (United States)

    Galerkin, Y. B.; Voinov, I. B.; Drozdov, A. A.

    2017-08-01

    Computational Fluid Dynamics (CFD) methods are widely used for centrifugal compressors design and flow analysis. The calculation results are dependent on the chosen software, turbulence models and solver settings. Two of the most widely applicable programs are NUMECA Fine Turbo and ANSYS CFX. The objects of the study were two different stages. CFD-calculations were made for a single blade channel and for full 360-degree flow paths. Stage 1 with 3D impeller and vaneless diffuser was tested experimentally. Its flow coefficient is 0.08 and loading factor is 0.74. For stage 1 calculations were performed with different grid quality, a different number of cells and different models of turbulence. The best results have demonstrated the Spalart-Allmaras model and mesh with 1.854 million cells. Stage 2 with return channel, vaneless diffuser and 3D impeller with flow coefficient 0.15 and loading factor 0.5 was designed by the known Universal Modeling Method. Its performances were calculated by the well identified Math model. Stage 2 performances by CFD calculations shift to higher flow rate in comparison with design performances. The same result was obtained for stage 1 in comparison with measured performances. Calculated loading factor is higher in both cases for a single blade channel. Loading factor performance calculated for full flow path (“360 degrees”) by ANSYS CFX is in satisfactory agreement with the stage 2 design performance. Maximum efficiency is predicted accurately by the ANSYS CFX “360 degrees” calculation. “Sector” calculation is less accurate. Further research is needed to solve the problem of performances mismatch.

  8. Strategies of Voshmgir Dam Water Allocation Using Two-Stage Stochastic Programming

    Directory of Open Access Journals (Sweden)

    elham kalbali

    2017-03-01

    Full Text Available Introduction: In the present study, dealing with water deficit challenges for Gorgan River Basin has been considered. Golestan province's economy is dependent on agriculture but the occurrence of drought periods reduced the agricultural production and consequently the region's economy is in crisis. Therefore, performing studies for programming and management of the water resources of the province and the water allocation in the margin of Voshmgir dam in Gorganrood basin has a great deal of importance. The issue of the allocation of water resources is proposed in order to maximize the expected profit of the water system. According to the regional water organization policy, one of the main goals of Voshmgir dam water management is the allocation of water between the competing consumers. If the amount of promised water is released in the future, the expected net profit of the system will be realized and if it is not released, the system will experience losses. Materials and Methods: In this studyWater supply is considered stochasticand objective function of the model is to maximize the system (Agriculture, Aquaculture and Environment profit and optimal allocation of water during the programming period using a two-stage stochastic model as follows: Constraint of the available land: Constraint of the available water in each of the main canals: Constraint of the available water: Constraint of the amount of inflow water Reservoir capacity constraint Constraint on the maximum and minimum water demand for environmental sector Constraint on the maximum and minimum water demand for crops Constraint on the maximum and minimum water demand for warm-water fish Constraint on non-negativity of the decision variables in the model Results and Discussion: The length of the right main canal of this network is about 17.76 km and the length of the left main canal is about 21.338 km. In this study, is considered for the right main canal and is considered for left main

  9. A Nationwide Cohort Study of Stage I Seminoma Patients Followed on a Surveillance Program

    DEFF Research Database (Denmark)

    Mortensen, Mette Saksø; Lauritsen, Jakob; Gundgaard, Maria Gry

    2014-01-01

    -based study of Danish patients diagnosed with stage I seminoma between 1984 and 2008 and followed for 5 yr (n=1954). Patient data were linked with national registries on November 30, 2012, to obtain information on late relapse, vital status, and cause of death. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS...

  10. A new model for catalyzing translational science: the early stage investigator mentored research scholar program in HIV vaccines.

    Science.gov (United States)

    Adamson, Blythe J S; Fuchs, Jonathan D; Sopher, Carrie J; Flood, Danna M; Johnson, R Paul; Haynes, Barton F; Kublin, James G

    2015-04-01

    Engagement of early stage investigators (ESIs) in the search for a safe and effective vaccine is critical to the success of this highly challenging endeavor. In the wake of disappointing results from a large-scale efficacy trial, the HIV Vaccine Trials Network (HVTN) and Center for HIV/AIDS Vaccine Immunology (CHAVI) developed a novel mentored research program focused on the translation of findings from nonhuman primate studies to human trials of experimental vaccines. From 2008 to 2011, 14 ESI Scholars were selected from 42 complete applications. Post program surveys and tracked outcomes suggest that the combination of flexible funding, transdisciplinary mentorship, and structured training and networking promoted the scientific contributions and career development of promising ESIs. Embedding a multicomponent research program within collaborative clinical trial networks and research consortia is a promising strategy to attract and retain early career investigators and catalyze important translational science. © 2014 Wiley Periodicals, Inc.

  11. Prognostic value of programmed death ligand 1, p53, and Ki-67 in patients with advanced stage colorectal cancer.

    Science.gov (United States)

    Wang, Lisha; Liu, Zebing; Fisher, Kurt W; Ren, Fei; Lv, Jiaojie; Davidson, Darrell D; Baldridge, Lee A; Du, Xiang; Cheng, Liang

    2017-08-04

    Current prognostic indicators are ineffective for identifying advanced stage colorectal cancer (CRC) patients with high risk of recurrence after surgical resection. We investigated the prognostic value of p53, Ki-67, and programmed death ligand 1 (PD-L1) in 254 patients with stage II and III CRC. The expression of p53 was positive in 63% of cases. Up-regulation of p53 was associated with smaller tumor size (P=.001) and higher Ki-67 labeling index (LI) (P=.031). The tumor Ki-67 LI was high (≥ 20%) in 197 (78%) of the patients. High Ki-67 LI was associated with higher TNM stage (P=.031), positive p53 expression (P=.031), and negative PD-L1 expression (P=.003). The five-year relapse-free survivals (RFS) were 53% and 89%, respectively, for the p53-positive and Ki-67 LI-high patients and the p53-negative and Ki-67 LI-low patients (Pp53 (P=.001), low Ki-67 LI (P=.006), low PD-L1 expression (P=.044), low TNM stage (Pp53 expression (hazard ratio [HR]: 2.48; 95% confidence interval: 1.34-4.59, P=.004), high Ki-67 LI (HR: 2.62; 95% CI: 1.12-6.14, P=.027) and high TNM stage (HR: 2.598, 95% CI: 1.55-4.37, Pp53 staining individually had significant prognostic value for patients with stage II and III CRC. Moreover, combining p53 H-score≥35 and Ki-67 LI≥20% identifies patients with poor clinical outcome. Copyright © 2017. Published by Elsevier Inc.

  12. Cost-effectiveness of a transitional home-based palliative care program for patients with end-stage heart failure.

    Science.gov (United States)

    Wong, Frances Kam Yuet; So, Ching; Ng, Alina Yee Man; Lam, Po-Tin; Ng, Jeffrey Sheung Ching; Ng, Nancy Hiu Yim; Chau, June; Sham, Michael Mau Kwong

    2018-02-01

    Studies have shown positive clinical outcomes of specialist palliative care for end-stage heart failure patients, but cost-effectiveness evaluation is lacking. To examine the cost-effectiveness of a transitional home-based palliative care program for patients with end-stage heart failure patients as compared to the customary palliative care service. A cost-effectiveness analysis was conducted alongside a randomized controlled trial (Trial number: NCT02086305). The costs included pre-program training, intervention, and hospital use. Quality of life was measured using SF-6D. The study took place in three hospitals in Hong Kong. The inclusion criteria were meeting clinical indicators for end-stage heart failure patients including clinician-judged last year of life, discharged to home within the service area, and palliative care referral accepted. A total of 84 subjects (study = 43, control = 41) were recruited. When the study group was compared to the control group, the net incremental quality-adjusted life years gain was 0.0012 (28 days)/0.0077 (84 days) and the net incremental costs per case was -HK$7935 (28 days)/-HK$26,084 (84 days). The probability of being cost-effective was 85% (28 days)/100% (84 days) based on the cost-effectiveness thresholds recommended both by National Institute for Health and Clinical Excellence (£20,000/quality-adjusted life years) and World Health Organization (Hong Kong gross domestic product/capita in 2015, HK$328117). Results suggest that a transitional home-based palliative care program is more cost-effective than customary palliative care service. Limitations of the study include small sample size, study confined to one city, clinic consultation costs, and societal costs including patient costs and unpaid care-giving costs were not included.

  13. Teen Choices, an Online Stage-Based Program for Healthy, Nonviolent Relationships: Development and Feasibility Trial

    Science.gov (United States)

    Levesque, Deborah A.; Johnson, Janet L.; Prochaska, Janice M.

    2017-01-01

    This article describes the theoretical foundation, development, and feasibility testing of an online, evidence-based intervention for teen dating violence prevention designed for dissemination. Teen Choices, a program for healthy, nonviolent relationships, relies on the transtheoretical model of behavior change and expert system technology to…

  14. Online Certificate Program Moves Participants to Advanced Stages of Concern for Social Marketing

    Science.gov (United States)

    Chaudhary, Anil Kumar; Warner, Laura A.; Stofer, Kathryn A.

    2017-01-01

    Social marketing is an underused strategy that agricultural educators can employ to bring about behavior change. We designed an online certificate program for Extension professionals and other educators based on an identified need for social marketing professional development. The Concerns-Based Adoption Model (CBAM) served as the conceptual…

  15. 78 FR 8535 - Medicare Program: Comprehensive End-Stage Renal Disease Care Model Announcement

    Science.gov (United States)

    2013-02-06

    ... functional status, quality of life, and overall well-being, as well as increased beneficiary and caregiver... or enhancing the quality of care for Medicare, Medicaid, and Children's Health Insurance Program... an interdisciplinary care team that is led by a nephrologist, comprised of dialysis facilities...

  16. Effect of a home exercise program based on tai chi in patients with end-stage renal disease.

    Science.gov (United States)

    Ling, Kin-wa; Wong, Flora S Y; Chan, Wing-ki; Chan, Shuk-yin; Chan, Eric P Y; Cheng, Yuk-lun; Yu, Wai-yin

    2003-12-01

    Previous reports have documented the benefits of exercise on the well-being of renal patients. However, fewer than 50% of our end-stage renal disease (ESRD) patients engage in regular exercise. To promote exercise, we implemented a home-based exercise program. The aim of the program was to reduce barriers to exercise by helping patients to exercise at their convenience and without the need to travel. The effect of the program was evaluated 3 months after implementation. Each study participant received a videotape that demonstrated 30 minutes of low-capacity aerobic exercise. Participants were advised to exercise by following the demonstration on the videotape. Encouragement was given over the telephone. Self-reports on practice were recorded in a log book that was also provided. The effect of the program was evaluated by comparing outcomes data before, and 3 months after, implementation of the program. Outcomes assessment included functional mobility (timed "Up & Go" test), muscle flexibility ("Sit & Reach" test), physical capacity ("Six-Minute Walk"), and quality of life [Kidney Disease Quality of Life Short Form (KDQOL-SF)]. The program began with 72 participants. Over time, 39 dropped out. The remaining 33 participants included 11 men and 22 women with a mean age of 52.8 +/- 9.8 years. They exercised 3 - 7 times weekly. Significant improvements were observed in the timed "Up & Go" (p = 0.003) and "Sit & Reach" (p exercise. A home-based program provides an alternative to outdoor and group exercise. In view of a high drop-out rate, intensive promotion and encouragement should be considered to achieve a positive outcome.

  17. A mathematical programming framework for early stage design of wastewater treatment plants

    DEFF Research Database (Denmark)

    Bozkurt, Hande; Quaglia, Alberto; Gernaey, Krist

    2015-01-01

    The increasing number of alternative wastewater treatment technologies and stricter effluent requirements make the optimal treatment process selection for wastewater treatment plant design a complicated problem. This task, defined as wastewater treatment process synthesis, is currently based on e...... the design problem is formulated as a Mixed Integer (Non)linear Programming problem e MI(N)LP e and solved. A case study is formulated and solved to highlight the application of the framework. © 2014 Elsevier Ltd. All rights reserved....

  18. Installation Restoration Program. Phase 2. Confirmation/Quantification. Stage 2. Duluth International Airport, Duluth, Minnesota. Appendix

    Science.gov (United States)

    1988-05-26

    collected. Test each drum containing suspected contaminated soils by taking a composite sample. Collect a maximum of 15 composite samples and test them for... incrustation , well interference, and similar operation and mainte ance problems (5) Location, type, geologic setting, and hydrographs of springs (6...assessment at a plastics manufacturing plant in north- central Illinois. Program included collecting composite soil and water samples for analyses. o Logged

  19. Conclusions drawn from actions implemented within the first stage of the Cracow program of energy conservation and clean fossil fuels

    Energy Technology Data Exchange (ETDEWEB)

    Bieda, J.; Bardel, J.; Pierce, B.

    1995-12-31

    Since 1992 Brookhaven National Laboratory (BNL) and Pacific Northwest Laboratory (PNL), acting on behalf of the U.S. Department of Energy, executed the first stage of the Cracow Program of Energy Conservation and Clean Fossil Fuels, called also American-Polish Program of Actions for Elimination of Low Emission Sources in Cracow. The main contractor for BNL and PNL was the Cracow Development Office (BRK). The interest in improving the condition of Cracow air results from the fact that the standard for permissible air pollution was exceeded several times in Cracow and especially within the central part of the town. Therefore, air pollution appeared one of the most important problems that faced the municipal authorities. It followed from monitoring investigations that the high level of air pollutant concentration is caused by in-home coal-fired tile stoves operated in winter seasons and by coal- and coke-fired boiler houses simulated mainly in the central part of the town. The results obtained in first stage are presented. This paper is an attempt to formulate conclusions drawn from these works and recommendations with regard to the future policy of the town authorities; selected results are presented to clarify or illustrate the conclusions.

  20. An inexact two-stage stochastic programming model for water resources management in Nansihu Lake Basin, China.

    Science.gov (United States)

    Xie, Y L; Huang, G H; Li, W; Li, J B; Li, Y F

    2013-09-30

    In this study, an inexact two-stage water resources management model was developed for multi-regional water resources planning in the Nansihu lake Basin, China. Four planning districts, four water users, and five water sources were considered in the optimization model, with net system benefit, recourse cost, water supply cost, and wastewater treatment cost being analyzed. Methods of interval-parameter programming (IPP) and two-stage stochastic programming (TSP) were incorporated into the model to tackle uncertainties described by both interval values and probability distributions. A number of scenarios corresponding to different river inflow levels were examined, and the results indicated that different inflow levels could lead to different water allocation schemes with varied system benefit and system-failure risk. In general, the developed model can provide an effective linkage between economic benefits and the associated penalties attributed to the violation of predefined policies. The modeling results were valuable for supporting the adjustment or justification of the existing water allocation schemes within a complicated water resources system under uncertainty. Copyright © 2013 Elsevier Ltd. All rights reserved.

  1. Stages of change of behavior in women on a multi-professional program for treatment of obesity

    Directory of Open Access Journals (Sweden)

    Cheila Aparecida Bevilaqua

    Full Text Available ABSTRACT Objective: to ascertain the effectiveness of an intervention program in relation to anthropometric measurements and stage of readiness for behavioral change in women with excess weight. Methods: the intervention group (IG was made up of 13 women, and the control group (CG, by 20. The intervention lasted 16 weeks, and included the practice of guided physical activity three times a week, and health education once a week. The application of the questionnaire on stage of readiness for behavioral change, and the anthropometric evaluations, were undertaken at two points - before and after the period of intervention. The statistical analysis involved tests of comparison and association. Results: in general, at the first point, the participants in the two groups were predisposed to make changes in what they ate and in their physical activity. However, significant difference was only observed in relation to weight, body mass index (BMI, waist circumference and waist-hip ratio and readiness for change among the members of the intervention group. Conclusion: the intervention programmed was effective in weight loss, reduction of waist circumference and waist-hip ratio, and in changing behaviors related to the practicing of physical exercise and eating habits.

  2. Progression of stages 3b–5 chronic kidney disease—Preliminary results of Taiwan National Pre-ESRD Disease Management Program in Southern Taiwan

    Directory of Open Access Journals (Sweden)

    Chun-Mei Lin

    2013-12-01

    Conclusion: Even though we cannot conclude with certainty that the Taiwan pre-ESRD disease management program is beneficial in slowing the progression of CKD stages 3b–5, our preliminary results seem to suggest this trend. Furthermore, the program may be improved by integrating it with other programs, such as those on diabetes and hypertension, thus making it a more patient-centered, multidisciplinary program.

  3. Stochastic multi-stage optimization at the crossroads between discrete time stochastic control and stochastic programming

    CERN Document Server

    Carpentier, Pierre; Cohen, Guy; De Lara, Michel

    2015-01-01

    The focus of the present volume is stochastic optimization of dynamical systems in discrete time where - by concentrating on the role of information regarding optimization problems - it discusses the related discretization issues. There is a growing need to tackle uncertainty in applications of optimization. For example the massive introduction of renewable energies in power systems challenges traditional ways to manage them. This book lays out basic and advanced tools to handle and numerically solve such problems and thereby is building a bridge between Stochastic Programming and Stochastic Control. It is intended for graduates readers and scholars in optimization or stochastic control, as well as engineers with a background in applied mathematics.

  4. Adobe Flash 11 Stage3D (Molehill) Game Programming Beginner's Guide

    CERN Document Server

    Kaitila, Christer

    2011-01-01

    Written in an informal and friendly manner, the style and approach of this book will take you on an exciting adventure. Piece by piece, detailed examples help you along the way by providing real-world game code required to make a complete 3D video game. Each chapter builds upon the experience and achievements earned in the last, culminating in the ultimate prize - your game! If you ever wanted to make your own 3D game in Flash, then this book is for you. This book is a perfect introduction to 3D game programming in Adobe Molehill for complete beginners. You do not need to know anything about S

  5. Rigid Origami via Optical Programming and Deferred Self-Folding of a Two-Stage Photopolymer.

    Science.gov (United States)

    Glugla, David J; Alim, Marvin D; Byars, Keaton D; Nair, Devatha P; Bowman, Christopher N; Maute, Kurt K; McLeod, Robert R

    2016-11-02

    We demonstrate the formation of shape-programmed, glassy origami structures using a single-layer photopolymer with two mechanically distinct phases. The latent origami pattern consisting of rigid, high cross-link density panels and flexible, low cross-link density creases is fabricated using a series of photomask exposures. Strong optical absorption of the polymer formulation creates depth-wise gradients in the cross-link density of the creases, enforcing directed folding which enables programming of both mountain and valley folds within the same sheet. These multiple photomask patterns can be sequentially applied because the sheet remains flat until immersed into a photopolymerizable monomer solution that differentially swells the polymer to fold and form the origami structure. After folding, a uniform photoexposure polymerizes the absorbed solution, permanently fixing the shape of the folded structure while simultaneously increasing the modulus of the folds. This approach creates sharp folds by mimicking the stiff panels and flexible creases of paper origami while overcoming the traditional trade-off of self-actuated materials that require low modulus for folding and high modulus for mechanical robustness. Using this process, we demonstrate a waterbomb base capable of supporting 1500 times its own weight.

  6. The UCLA reading and writing program: an evaluation of the beginning stages.

    Science.gov (United States)

    Eikeseth, S; Jahr, E

    2001-01-01

    Some individuals with developmental disabilities fail to acquire functional speech despite extensive teaching efforts. To help such individuals develop functional communication skills, a "reading and writing" program was developed. This study was designed to evaluate early parts of the program. Acquisition, transfer, and maintenance of "reading and writing" skills was examined and compared with the acquisition, transfer, and maintenance of sign language. Participants were four children with autism, who scored within the mentally retarded range on standardized tests of intellectual, adaptive, and language functioning, and three 3-year-old non-disabled children. A simultaneous-treatment design was employed to compare the rate of acquisition of "reading and writing" skills to the rate at which the participants acquired receptive and expressive signs. For the participants with autism, acquisition of "reading and writing" was more successful than receptive and expressive signing on all variables assessed. All non-disabled participants acquired all of the "reading and writing" and sign language skills, but participants with autism did not. However, "reading" was acquired slightly quicker by the participants with autism than the non-disabled participants, and the participants with autism also showed some evidence of better transfer and maintenance than the non-disabled participants did.

  7. Optimal phasing of district heating network investments using multi-stage stochastic programming

    Directory of Open Access Journals (Sweden)

    Romain Stephane Claude Lambert

    2016-06-01

    Full Text Available Most design optimisation studies for district heating systems have focused on the optimal sizing of network assets and on the location of production units. However, the strategic value of the flexibility in phasing of the inherently modular heat networks, which is an important aspect in many feasibility studies for district heating schemes in the UK, is almost always neglected in the scientific literature. This paper considers the sequential problem faced by a decision-maker in the phasing of long-term investments into district heating networks and their expansions. The problem is formulated as a multi-stage stochastic programme to determine the annual capital expenditure that maximises the expected net present value of the project. The optimisation approach is illustrated by applying it to the hypothetical case of the UK’s Marston Vale eco town. It was found that the approach is capable of simulating the optimal growth of a network, from both a single heat source or separate islands of growth, as well as the optimal marginal expansion of an existing district heating network. The proposed approach can be used by decision makers as a framework to determine both the optimal phasing and extension of district heating networks and can be adapted simply to various, more complex real-life situations by introducing additional constraints and parameters. The versatility of the base formulation also makes it a powerful approach regardless of the size of the network and also potentially applicable to cooling networks.

  8. Human Research Program Human Health Countermeasures Element Extravehicular Activity (EVA) Risk Standing Review Panel (SRP)

    Science.gov (United States)

    Norfleet, William; Harris, Bernard

    2009-01-01

    The Extravehicular Activity (EVA) Risk Standing Review Panel (SRP) was favorably impressed by the operational risk management approach taken by the Human Research Program (HRP) Integrated Research Plan (IRP) to address the stated life sciences issues. The life sciences community at the Johnson Space Center (JSC) seems to be focused on operational risk management. This approach is more likely to provide risk managers with the information they need at the time they need it. Concerning the information provided to the SRP by the EVA Physiology, Systems, and Performance Project (EPSP), it is obvious that a great deal of productive activity is under way. Evaluation of this information was hampered by the fact that it often was not organized in a fashion that reflects the "Gaps and Tasks" approach of the overall Human Health Countermeasures (HHC) effort, and that a substantial proportion of the briefing concerned subjects that, while interesting, are not part of the HHC Element (e.g., the pressurized rover presentation). Additionally, no information was provided on several of the tasks or how they related to work underway or already accomplished. This situation left the SRP having to guess at the efforts and relationship to other elements, and made it hard to easily map the EVA Project efforts currently underway, and the data collected thus far, to the gaps and tasks in the IRP. It seems that integration of the EPSP project into the HHC Element could be improved. Along these lines, we were concerned that our SRP was split off from the other participating SRPs at an early stage in the overall agenda for the meeting. In reality, the concerns of EPSP and other projects share much common ground. For example, the commonality of the concerns of the EVA and exercise physiology groups is obvious, both in terms of what reduced exercise capacity can do to EVA capability, and how the exercise performed during an EVA could contribute to an overall exercise countermeasure prescription.

  9. A Citizen Science Program for Monitoring Lake Stages in Northern Wisconsin

    Science.gov (United States)

    Kretschmann, A.; Drum, A.; Rubsam, J.; Watras, C. J.; Cellar-Rossler, A.

    2011-12-01

    Historical data indicate that surface water levels in northern Wisconsin are fluctuating more now than they did in the recent past. In the northern highland lake district of Vilas County, Wisconsin, concern about record low lake levels in 2008 spurred local citizens and lake associations to form a lake level monitoring network comprising citizen scientists. The network is administered by the North Lakeland Discovery Center (NLDC, a local NGO) and is supported by a grant from the Citizen Science Monitoring Program of the Wisconsin Department of Natural Resources (WDNR). With technical guidance from limnologists at neighboring UW-Madison Trout Lake Research Station, citizen scientists have installed geographic benchmarks and staff gauges on 26 area lakes. The project engages citizen and student science participants including homeowners, non-profit organization member-participants, and local schools. Each spring, staff gauges are installed and referenced to fixed benchmarks after ice off by NLDC and dedicated volunteers. Volunteers read and record staff gauges on a weekly basis during the ice-free season; and maintain log books recording lake levels to the nearest 0.5 cm. At the end of the season, before ice on, gauges are removed and log books are collected by the NLDC coordinator. Data is compiled and submitted to a database management system, coordinated within the Wisconsin Surface Water Integrated Monitoring System (SWIMS), a statewide information system managed by the WDNR in Madison. Furthermore, NLDC is collaborating with the SWIMS database manager to develop data entry screens based on records collected by citizen scientists. This program is the first of its kind in Wisconsin to utilize citizen scientists to collect lake level data. The retention rate for volunteers has been 100% over the three years since inception, and the program has expanded from four lakes in 2008 to twenty-six lakes in 2011. NLDC stresses the importance of long-term monitoring and the

  10. CERTIFICATION - The final and critical stage of every civil or military aviation program

    Directory of Open Access Journals (Sweden)

    Vasile STEFAN

    2012-06-01

    Full Text Available As a general rule the final step in every aviation program is the certification of the airplane, an important step in which the airplane, the engins and the equipments are checked by an authority or commission according to the airworthiness rules. The main scope of the certification is to promote a safe aviation product and to protect the general public from unnecessary risk. In all the contries the national authorieties require a civil certificability for all the parts or equipments and a full aircraft certification for a new or wholly modified airplane. The military aircrafts must pased and respond to a specific way of certification and many actual efforts are done in order to unify the diffrent national rules in this field. This paper presents the existing situation in the certification of civil and military airplans and the actual measures done for the unification of certification procedures in the world.

  11. Yield curve event tree construction for multi stage stochastic programming models

    DEFF Research Database (Denmark)

    Rasmussen, Kourosh Marjani; Poulsen, Rolf

    Dynamic stochastic programming (DSP) provides an intuitive framework for modelling of financial portfolio choice problems where market frictions are present and dynamic re--balancing has a significant effect on initial decisions. The application of these models in practice, however, is limited...... by the quality and size of the event trees representing the underlying uncertainty. Most often the DSP literature assumes existence of ``appropriate'' event trees without defining and examining qualities that must be met (ex--ante) in such an event tree in order for the results of the DSP model to be reliable....... Indeed defining a universal and tractable framework for fully ``appropriate'' event trees is in our opinion an impossible task. A problem specific approach to designing such event trees is the way ahead. In this paper we propose a number of desirable properties which should be present in an event tree...

  12. Transitioning home: A four-stage reintegration hospital discharge program for adolescents hospitalized for eating disorders.

    Science.gov (United States)

    Dror, Sima; Kohn, Yoav; Avichezer, Mazal; Sapir, Benjamin; Levy, Sharon; Canetti, Laura; Kianski, Ela; Zisk-Rony, Rachel Yaffa

    2015-10-01

    Treatment for adolescents with eating disorders (ED) is multidimensional and extends after hospitalization. After participating in a four-step reintegration plan, treatment success including post-discharge community and social reintegration were examined from perspectives of patients, family members, and healthcare providers. Six pairs of patients and parents, and seven parents without their children were interviewed 2 to 30 months following discharge. All but two adolescents were enrolled in, or had completed school. Five worked in addition to school, and three completed army or national service. Twelve were receiving therapeutic care in the community. Adolescents with ED can benefit from a systematic reintegration program, and nurses should incorporate this into care plans. © 2015, Wiley Periodicals, Inc.

  13. The Effects of a Roommate-Pairing Program on International Student Satisfaction and Academic Success

    Science.gov (United States)

    Tolman, Steven

    2017-01-01

    While great attention has been given to the growth of international students at U.S. institutions, there is a gap in the literature examining support for this student population within residence halls. To address the gap, this quantitative study evaluated an international roommate-pairing program (IRP) by comparing the residential experience of…

  14. Exercise training in patients with end-stage renal disease on hemodialysis: comparison of three rehabilitation programs.

    Science.gov (United States)

    Konstantinidou, Erasmia; Koukouvou, Georgia; Kouidi, Evangelia; Deligiannis, Asterios; Tourkantonis, Achilleas

    2002-01-01

    Functional capacity of end-stage renal disease patients is dramatically impaired. Although exercise training programs appear to have beneficial morphological, functional and psychosocial effects in end-stage renal disease patients on hemodialysis (HD), the adherence rate is high. The purpose of this study was to compare the effects of three modes of exercise training on aerobic capacity and to identify the most favourable, efficient and preferable to patients on HD with regard to functional improvements and participation rate in the programs. Fifty-eight volunteer patients were screened for low-risk status and selected from the dialysis population. The 48 patients who completed the study protocol were randomly assigned either to one of the three training groups or to a control group. Sixteen of them (Group A - mean age 46.4+/-13.9 years) completed a 6-month supervised outpatient exercise renal rehabilitation program consisting of three weekly sessions of aerobic and strengthening training on the non-dialysis days; 10 (Group B - mean age 48.3+/-12.1 years) completed a 6-month exercise program during HD; 10 (Group C - mean age 51.4+/-12.5 years) followed an unsupervised moderate exercise program at home, and 12 patients (Group D-mean age 50.2+/-7.9 years) were used as patient controls. The level of anemia, the medications and the HD prescription remained stable during the study. Fifteen sex- and age-matched sedentary individuals (Group E - mean age 46.9+/-6.4 years) comprised a healthy control group for baseline data. All subjects at the beginning and end of the study underwent clinical examination, laboratory tests and a treadmill exercise test to fatigue endpoints with direct measurement of aerobic capacity. Group A had a higher dropout rate (24%) compared to groups B (17%) and C (17%). Peak oxygen consumption (VO2 peak) increased by 43% (p exercise time by 33% (p exercise training on non-dialysis days is the most effective way of training, whereas exercise during

  15. Associations between Poor Sleep Quality and Stages of Change of Multiple Health Behaviors among Participants of Employee Wellness Program.

    Science.gov (United States)

    Hui, Siu-Kuen Azor; Grandner, Michael A

    2015-01-01

    Using the Transtheoretical Model of behavioral change, this study evaluates the relationship between sleep quality and the motivation and maintenance processes of healthy behavior change. The current study is an analysis of data collected in 2008 from an online health risk assessment (HRA) survey completed by participants of the Kansas State employee wellness program (N=13,322). Using multinomial logistic regression, associations between self-reported sleep quality and stages of change (i.e. precontemplation, contemplation, preparation, action, maintenance) in five health behaviors (stress management, weight management, physical activities, alcohol use, and smoking) were analyzed. Adjusted for covariates, poor sleep quality was associated with an increased likelihood of contemplation, preparation, and in some cases action stage when engaging in the health behavior change process, but generally a lower likelihood of maintenance of the healthy behavior. The present study demonstrated that poor sleep quality was associated with an elevated likelihood of contemplating or initiating behavior change, but a decreased likelihood of maintaining healthy behavior change. It is important to include sleep improvement as one of the lifestyle management interventions offered in EWP to comprehensively reduce health risks and promote the health of a large employee population.

  16. Installation Restoration Program (IRP) Site Investigation Report for IRP Site Number 4. Volume 3. Appendices D-I. 128th Air Refueling Wing, Wisconsin Air National Guard, General Billy Mitchell Field Air National Guard Base, Milwaukee, Wisconsin.

    Science.gov (United States)

    1996-03-01

    state the kind of Record ofof casing, liner, shoe and other Use a red line to show casing fnmtis penetate the knd FINAL accessories used. or liner pipe...of finishing the well, amount of cement used in grouting, blasting, etc., should be given on reverse side. ChARLES GIBOUR & SONS Signature Complete... Charles Huff OR - Gridor ’Street No. Street Name ADDRESS 5 7165 Pennsylvania Ave. same AND - If available subdivision name, lot & block No. POST OFFICE

  17. Installation Restoration Program (IRP) Site Investigation Report for IRP Site Number 4. Volume 2. Appendices A-C. 128th Air Refueling Wing, Wisconsin Air National Guard, General Billy Mitchell Field Air National Guard Base, Milwaukee, Wisconsin.

    Science.gov (United States)

    1996-03-01

    11 V S .c 23. 4 4 Urz.tno n 8072. e .’ SVc 89.0 0 5 UrIanjowo, 56. 96 m V S 248. 5 6 u., U n -ou.,rn 22.80 VSec 270. 4 * - 7 rIP x, ene .69. . ppm 324...8 Aux Flow 0 mt/min 9Oven Temp 40 Cmmi •i Amb Temp 34 C Max Gain 1000 151 Anaib Time 530.0 Cec P k, Compound Name Area./Conc R.T. h Unknown 14.91 mVS

  18. Preparations for the start-up of a research program in nuclear safeguards at Chalmers - Stage 2

    Energy Technology Data Exchange (ETDEWEB)

    Kitamura, Yasunori; Pazsit, Imre

    2004-12-01

    This report gives an account of the work performed at the Dept. of Reactor Physics at Chalmers Univ. of Technology in the second stage of the preparations for the start-up of a research program in nuclear safeguards and nuclear material management. The program is aimed at utilizing the experimental facilities as well as the experience in reactor physics, criticality safety, signal processing and unfolding, and experimental nuclear techniques, in tackling problems in non-destructive assay (NDA) of nuclear materials. During the present project, the following three main subjects were dealt with: first tests and pilot measurements were performed with one of the two newly acquired {sup 252}Cf detectors that were obtained from JNC Japan; the second exercise of the ESARDA benchmark. which consisted of the evaluation of the pulse train generated by Los Alamos Laboratory for multiplicity counting was performed and reported to the organisers of the benchmark; the modified Monte-Carlo code MCNP-PoliMi was installed, tested and work started for generating (although outside the ESARDA benchmark), pulse train data as obtained from various neutron sources with or without the presence of fissile material, as detected with an Active Well Coincidence Counter.

  19. Computer program for prediction of capture maneuver probability for an on-off reaction controlled upper stage

    Science.gov (United States)

    Knauber, R. N.

    1982-01-01

    A FORTRAN coded computer program which computes the capture transient of a launch vehicle upper stage at the ignition and/or separation event is presented. It is for a single degree-of-freedom on-off reaction jet attitude control system. The Monte Carlo method is used to determine the statistical value of key parameters at the outcome of the event. Aerodynamic and booster induced disturbances, vehicle and control system characteristics, and initial conditions are treated as random variables. By appropriate selection of input data pitch, yaw and roll axes can be analyzed. Transient response of a single deterministic case can be computed. The program is currently set up on a CDC CYBER 175 computer system but is compatible with ANSI FORTRAN computer language. This routine has been used over the past fifteen (15) years for the SCOUT Launch Vehicle and has been run on RECOMP III, IBM 7090, IBM 360/370, CDC6600 and CDC CYBER 175 computers with little modification.

  20. Screening for Sugarcane Brown Rust in the First Clonal Stage of the Canal Point Sugarcane Breeding Program

    Directory of Open Access Journals (Sweden)

    Duli Zhao

    2015-07-01

    Full Text Available Sugarcane (Saccharum spp. brown rust (caused by Puccinia melanocephala Syd. & P. Syd. was first reported in the United States in 1978 and is still one of the great challenges for sugarcane production. A better understanding of sugarcane genotypic variation in response to brown rust will help optimize breeding and selection strategies for disease resistance. Brown rust ratings were scaled from non-infection (0 to severe infection (4 with intervals of 0.5 and routinely recorded for genotypes in the first clonal selection stage of the Canal Point sugarcane breeding program in Florida. Data were collected from 14,272 and 12,661 genotypes and replicated check cultivars in 2012 and 2013, respectively. Mean rust rating, % infection, and severity in each family and progeny of female parent were determined, and their coefficients of variation (CV within and among families (females were estimated. Considerable variation exists in rust ratings among families or females. The families and female parents with high susceptibility or resistance to brown rust were identified and ranked. The findings of this study can help scientists to evaluate sugarcane crosses and parents for brown rust disease, to use desirable parents for crossing, and to improve genetic resistance to brown rust in breeding programs.

  1. Effectiveness of a nutrition education program for the prevention and treatment of malnutrition in end-stage renal disease.

    Science.gov (United States)

    Hernández Morante, Juan José; Sánchez-Villazala, Almudena; Cutillas, Ruben Cañavate; Fuentes, Mari Carmen Conesa

    2014-01-01

    In end-stage renal disease (ESRD) patients, malnutrition is mainly addressed from a pharmacological but not educational point of view. Therefore, the objective of this study was to implement a nutritional education program (NEP) and to evaluate and compare its effectiveness in the treatment and prevention of malnutrition with oral supplementation (OS)-the standard treatment in these patients. This study was a longitudinal, 4-month prospective study. The study was conducted from January to May 2012 in the Hemodialysis Fresenius Medical Care Clinic of Murcia. One hundred twenty patients with ESRD undergoing hemodialysis were randomly assigned to a NEP or to OS. Patients assigned to the NEP group followed an educational program for 4 months that aimed to improve general nutritional knowledge and included culinary recommendations and an elaboration of balanced menus. The OS group received a nutritional supplement during the hemodialysis procedure. The main outcome measure was certain biochemical markers of nutritional and metabolic status. Nutrition knowledge was also evaluated. After 4 months of intervention, nutritional knowledge was increased in all patients (P nutritional status, which may result in a long-term decrease in the mortality and morbidity of these patients. Copyright © 2014 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  2. NanTroSEIZE Stage 1 Expeditions 314, 315, and 316: First Drilling Program of the Nankai Trough Seismogenic Zone Experiment

    Directory of Open Access Journals (Sweden)

    Hideki Masago

    2009-09-01

    Full Text Available Integrated Ocean Drilling Program (IODP Expeditions 314, 315, and 316 were carried out as a unified program of drilling collectively known as Stage 1 of the Nankai Trough Seismogenic Zone Experiment, or NanTroSEIZE, the first multi-stage complex drilling project in IODP and the most ambitious effort in scientific ocean drilling to date (Tobin and Kinoshita, 2006b; Kinoshita et al., 2006. The first of four planned operational stages, the Stage 1 expeditions were conducted aboard the new riser-capable drilling vessel Chikyu from September 2007 to February 2008, and were Chikyu’s inaugural IODP expeditions. Seventy-one scientists from twelve countries took part in the three expeditions as shipboard participants, and thirty-three holes in total were drilled at eight sites, to as much as 1400 meters below the sea floor (Table 1, Fig. 1.

  3. Installation restoration program, remedial investigation/feasibility study report addendum for Indian Mountain Long Range Radar Station, Alaska. Final report, 1 August-18 December 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-01-01

    The following report is an addendum to the Indian Mountain Long Range Radar Station (LRRS) Remedial Investigation/Feasibility Study (RI/FS) report dated October 1995 (Air Force 1995a). This report and the activities described were undertaken to fulfill the goals and objectives of the Air Force Installation Restoration Program (IRP). This report includes findings from additional characterization activities conducted in August 1995 at five of 11 Indian Mountain IRP source areas and revisions to RI/FS report conclusions for those source areas.

  4. Research and development program in reactor diagnostics and monitoring with neutron noise methods. Stage 7. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Pazsit, I.; Demaziere, C.; Arzhanov, V. [Chalmers Univ. of Technology, Goeteborg (Sweden). Department of Reactor Physics; Garis, N.S. [Swedish Nuclear Power Inspectorate, Stockholm (Sweden)

    2001-08-01

    This report constitutes stage 7 of a long-term research and development program concerning the development of diagnostics and monitoring methods for nuclear reactors. A proposal for the continuation of this program in stage 8 is also given at the end of the report. In stage 6, the basic principles of a 3-D fully coupled neutronic/thermal-hydraulic simulator in the frequency domain were presented. The neutronic model relied on the two-group diffusion approximation, whereas the thermal-hydraulic algorithms relied on the so called 'lumped' model. The key element of this simulator was that only the static data were required which could be obtained from the Studsvik Scandpower CASMO-4/TABLES-3/ SIMULATE-3 code package. The simulator was developed with this underlying idea, which means that the calculation of the static fluxes and the eigenvalue were avoided. Depending on what kind of spatial discretization scheme which is used in the noise simulator to calculate the 'leakage' noise, it is not granted that the system remains critical by using the group constants supplied by SIMULATE. Nevertheless, when the system is critical, the balance equations should be fulfilled in all nodes with respect to the discretization scheme used. In concrete terms, the calculation of the static fluxes and eigenvalue can be avoided if the system is brought back to criticality by modifying the cross-sections so that the balance equations are always fulfilled with the chosen spatial discretization scheme. This approach was used in this study with the finite difference scheme. As pointed out in stage 6, the finite difference scheme is relatively inefficient compared to finite elements or nodal methods, but on the other hand it is rather easy to implement. These two more sophisticated schemes are planned to be investigated at a later stage, but for the time being the simulator relying on the finite difference scheme was improved as much as possible so that a 2-D entirely

  5. IRP stage 2 remedial investigation/feasibility study, Appendix L, for Bomarc Missile Site, McGuire AFB, New Jersey. Final report, November 1989-May 1992

    Energy Technology Data Exchange (ETDEWEB)

    Watts, P.; Collins, D.

    1992-05-26

    This document is an appendix of the final RI/FS report for the BOMARC Missile Site, McGuire AFB, New Jersey. The BOMARC site became contaminated in 1960 as the result of a fire which partially consumed a nuclear warhead-equipped BOMARC missile. The purpose of the RI/FS report is to document the extent and magnitude of environmental contamination at the site, to assess risks to human health and the environment, to determine the need for site remediation, and to evaluate feasible remedial alternatives. Appendix L contains tables of analytical data.

  6. IRP Stage 2 Remedial Investigation/Feasibility Study, Appendices A through K and M through R, for BOMARC Missile Site, McGuire AFB, New Jersey.

    Science.gov (United States)

    1992-05-26

    This plan was submitted on February 23, 1989 to Joseph Nycz -at the U. S. Occupational Safety and Health Administration in Marlton, New Jersey and to the...for theSBOMARC Missile Site, McGuire AFB, New Jersey. This plan was submitted on February 23, 1989 to Joseph Nycz at the U. S. Occupational Safety and

  7. Effectiveness of a community-based program for suicide prevention among elders with early-stage dementia: A controlled observational study.

    Science.gov (United States)

    Kim, Jong-Pill; Yang, Jinhyang

    The purpose of this study was to develop a small-group-focused suicide prevention program for elders with early-stage dementia and to assess its effects. This was a quasi-experimental study with a control group pretest-posttest design. A total of 62 elders diagnosed with early-stage dementia who were receiving care services at nine daycare centers in J City Korea participated in this study. The experimental group participated in the suicide prevention program twice a week for 5 weeks with a pretest and two posttests The developed suicide prevention program had a significant effect on the perceived health status, social support, depression, and suicidal ideation of elders with early-stage dementia. Nurses should integrate risk factors such as depression and protective factors such as health status and social support into a suicide prevention program. This community-based program in geriatric nursing practice can be effective in preventing suicide among elders with early-stage dementia. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. A Multistage Longitudinal Comparative (MLC) Design Stage II: Evaluation of the Changing Lives Program (CLP)--The Possible Selves Questionnaire-Qualitative Extensions (PSQ-QE)

    Science.gov (United States)

    Kortsch, Gabrielle; Kurtines, William M.; Montgomery, Marilyn J.

    2008-01-01

    The study reported in this paper, a Multistage Longitudinal Comparative (MLC) Design Stage II evaluation conducted as a planned preliminary efficacy evaluation (psychometric evaluation of measures, short-term controlled outcome studies, etc.) of the Changing Lives Program (CLP), provided evidence for the reliability and validity of qualitative…

  9. The Influence of Religious Awareness Program in Scaling down Death Anxiety among Children Sample in Late Childhood Stage; 9-12 Years Old in Al Shobak Province

    Science.gov (United States)

    Al-Mohtadi, Reham Mohammad; Al-Msubheen, Moonerh Mheel

    2017-01-01

    This study drives at identifying the influence of religious awareness program in scaling down the death anxiety among sample consisted of (50) students; (30) males and (20) females, at the late childhood stage. The sample distributed randomly into (25) students representing main group and (25) students as experimental group. Religious Awareness…

  10. Implementation of equity in resource allocation for regional earthquake risk mitigation using two-stage stochastic programming.

    Science.gov (United States)

    Zolfaghari, Mohammad R; Peyghaleh, Elnaz

    2015-03-01

    This article presents a new methodology to implement the concept of equity in regional earthquake risk mitigation programs using an optimization framework. It presents a framework that could be used by decisionmakers (government and authorities) to structure budget allocation strategy toward different seismic risk mitigation measures, i.e., structural retrofitting for different building structural types in different locations and planning horizons. A two-stage stochastic model is developed here to seek optimal mitigation measures based on minimizing mitigation expenditures, reconstruction expenditures, and especially large losses in highly seismically active countries. To consider fairness in the distribution of financial resources among different groups of people, the equity concept is incorporated using constraints in model formulation. These constraints limit inequity to the user-defined level to achieve the equity-efficiency tradeoff in the decision-making process. To present practical application of the proposed model, it is applied to a pilot area in Tehran, the capital city of Iran. Building stocks, structural vulnerability functions, and regional seismic hazard characteristics are incorporated to compile a probabilistic seismic risk model for the pilot area. Results illustrate the variation of mitigation expenditures by location and structural type for buildings. These expenditures are sensitive to the amount of available budget and equity consideration for the constant risk aversion. Most significantly, equity is more easily achieved if the budget is unlimited. Conversely, increasing equity where the budget is limited decreases the efficiency. The risk-return tradeoff, equity-reconstruction expenditures tradeoff, and variation of per-capita expected earthquake loss in different income classes are also presented. © 2015 Society for Risk Analysis.

  11. Research and Development Program in Reactor Diagnostics and Monitoring with Neutron Noise Methods. Stage 11 and 12. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Sunde, C.; Pazsit, I.; Demaziere, C.; Dahl, O.; Mileshina, L. [Chalmers Univ. of Technology, Goeteborg (Sweden). Dept. of Nuclear Engineering

    2006-06-15

    This report describes the results obtained during Stage 11 and 12 of a long-term research and development program concerning the development of diagnostics and monitoring methods for nuclear reactors. The long-term goals are elaborated in more detail in e.g. the Final Reports of stage 1 and 2 (SKI Report 95:14 and 96:50). Higher order eigenfunctions and eigenvalues of the diffusion equation, describing a static core, have lost their significance when doing calculations in realistic systems, since there are usually made by nodal methods or other direct numerical techniques. However, there are situations when knowledge of the higher order modes is still useful. Such case is the separation of the global and regional flux oscillations in the case of BWR instability. Another case is the investigation of the stability properties of large inhomogeneous cores, which is usually quantified with the so-called eigenvalue separation, ES=1/k{sub 1} - 1/k{sub 0} where k{sub 0} and k{sub 1}, are the fundamental and first higher order eigenvalues, respectively. Numerical codes used for ICMF calculations usually do not have the option of calculating the higher order eigenvalues and eigenfunctions. In idealised systems, these can be calculated with semi-analytical methods. In order to get insight into the characteristics of the higher order eigenmodes of the neutron flux and the adjoint, these were calculated in a reflected homogeneous system with two-group theory. The adjoint eigenmodes are necessary if an orthogonality property needs to be used, such as the separation of the modes from a flux shape which is a sum of several eigenmodes. At the same time, the so-called numerical noise simulator, developed at the Dept., was extended such that it became suitable for the calculation of the higher order eigenmodes, both direct and adjoint ones. This simulator can treat real inhomogeneous cores, with an input deck compatible with that of SIMULATE. The simulator was used to calculate the

  12. 76 FR 18930 - Medicare Programs: Changes to the End-Stage Renal Disease Prospective Payment System Transition...

    Science.gov (United States)

    2011-04-06

    ...: Changes to the End-Stage Renal Disease Prospective Payment System Transition Budget-Neutrality Adjustment... period. SUMMARY: This interim final rule with comment will revise the end-stage renal disease (ESRD) transition budget-neutrality adjustment finalized in the CY 2011 ESRD Prospective Payment System (PPS) final...

  13. Improvement of the competitive program of woman’s pair in acrobatics by means of choreography at a stage of the specialized basic preparation

    Directory of Open Access Journals (Sweden)

    Petro Kyzim

    2016-04-01

    Full Text Available Purpose: to prove experimentally the technique of improvement of the competitive program of woman’s pair in acrobatics by means of choreography at a stage of the specialized basic preparation. Material & Methods: the following methods of the research were used: theoretical analysis and synthesis of data of special scientific and methodical literature; pedagogical supervision; pedagogical testing; methods of mathematical statistics. 10 competitive programs of woman’s pair in acrobatics are analyzed before and after the pedagogical experiment. Results: the estimated results of the technique of execution of the competitive program of each woman’s pair separately were received on the basis of a rating scale of criterion of implementation of the competitive program of woman’s pair in acrobatics (Rules of FIG, 2013–2016. The dynamic of the level of the competitive program of each woman’s pair separately is defined. Conclusions: it is established that additional resources of choreography influence significantly the level of the competitive program of woman’s pair in acrobatics at a stage of the specialized basic preparation

  14. Producción a nivel de laboratorio de Clostridium septicum IRP15 para la formulación de una vacuna veterinaria

    Directory of Open Access Journals (Sweden)

    María Lorena González Ramírez

    Full Text Available Objetivo: establecer las condiciones de producción a nivel de laboratorio de la alfa toxina de Clostridium septicum IRP15 para la formulación de una vacuna veterinaria y la optimización del proceso de producción. Métodos: se caracterizó y estandarizó la edad apropiada del inóculo para los cultivos en un fermentador New Brunswick Scientific 7 L. Las condiciones de cultivo fueron: cepa C. septicum IRP15, medio de cultivo VBH, 5 L/vaso de 7 L, inóculo de 250 mL (5 %, 37 ºC, 24 h, bajo agitaciones prueba de 0, 25 y 50 r.p.m. Se estableció el perfil cinético morfológico, de biomasa, consumo de sustrato y producción de toxina. Resultados: para las fermentaciones de 0 y 25 r.p.m. no se presentó fase de adaptación; el microorganismo creció de manera exponencial hasta las 4 y 6 h de fermentación, consumiendo simultáneamente la mayor cantidad de glucosa presente en el medio. A partir de estas horas y hasta las 24, se realizó la prueba de DL50 en ratones y se destaca que a 25 r.p.m. se obtuvo el mayor título de toxina (1/23. En las fermentaciones a 50 r.p.m. se observó que el microorganismo experimenta una fase de adaptación de 4 h aproximadamente; con un retardo en producción de biomasa, consumo de glucosa y producción de toxina, condición que no resulta óptima para la producción del antígeno. Conclusiones: la producción de toxina se presenta en la fase logarítmica y durante la fase estacionaria, asociándose así al crecimiento y al fenómeno de esporulación.

  15. Frequency of iss and irp2 genes by PCR method in Escherichia coli isolated from poultry with colibacillosis in comparison with healthy chicken in poultry farms of Zabol, South East of Iran.

    Science.gov (United States)

    Sadeghi Bonjar, M S; Salari, S; Jahantigh, M; Rashki, A

    2017-03-01

    There is no special trait for differentiation of Avian Pathogenic Escherichia coli from Avian Fecal Escherichia coli. This investigation is aimed, as a case control study, to evaluate and compare the frequency of iss and irp2 in 43 AFEC strains and also 40 and 56 E. coli strains isolated from the liver and kidney of chickens with colibacillosis, respectively, farmed in Zabol, as a border region of Iran, by PCR. 86.9% and 37.2% of isolates collected from chickens with colibacillosis and feces samples obtained from healthy chickens were positive for iss gene, respectively (PE. coli strains isolated from colibacillosis have irp2 gene while 27.9% of isolates from the feces of healthy birds were positive (Pchicken feces were positive for both genes, with statistical significant difference (p<0.05). This marked difference in the distribution of iss and irp2 genes makes these two genes good markers to differentiate AFEC and APEC strains especially in Sistan region to improve colibacillosis control measurements.

  16. Stages of change of behavior in women on a multi-professional program for treatment of obesity.

    Science.gov (United States)

    Bevilaqua, Cheila Aparecida; Pelloso, Sandra Marisa; Marcon, Sonia Silva

    2016-10-10

    to ascertain the effectiveness of an intervention program in relation to anthropometric measurements and stage of readiness for behavioral change in women with excess weight. the intervention group (IG) was made up of 13 women, and the control group (CG), by 20. The intervention lasted 16 weeks, and included the practice of guided physical activity three times a week, and health education once a week. The application of the questionnaire on stage of readiness for behavioral change, and the anthropometric evaluations, were undertaken at two points - before and after the period of intervention. The statistical analysis involved tests of comparison and association. in general, at the first point, the participants in the two groups were predisposed to make changes in what they ate and in their physical activity. However, significant difference was only observed in relation to weight, body mass index (BMI), waist circumference and waist-hip ratio and readiness for change among the members of the intervention group. the intervention programmed was effective in weight loss, reduction of waist circumference and waist-hip ratio, and in changing behaviors related to the practicing of physical exercise and eating habits. verificar a efetividade de um programa de intervenção sobre medidas antropométricas e o estágio de prontidão para mudança de comportamento em mulheres com excesso de peso. o grupo intervenção (GI) foi constituído por 13 mulheres e o grupo controle por 20. A intervenção teve duração de 16 semanas e incluiu prática de atividade física orientada três vezes na semana e educação em saúde uma vez na semana. A aplicação do questionário de estágio de prontidão para mudança de comportamento e as avaliações antropométricas foram realizadas em dois momentos, antes e após o período de intervenção. A análise estatística envolveu testes de comparação e associação. em geral, no momento inicial, as participantes dos dois grupos estavam

  17. The Impact of the Multi-sensory Program Alfabeto on the Development of Literacy Skills of Third Stage Pre-school Children

    Science.gov (United States)

    von Staa, Betina; Reis, Loureni; Scandola, Matilde Conceição Lescano

    Here we present the results of the pilot-project undertaken in ten Pre-Schools with third stage (5 year-old) children who used ALFABETO Multi-sensory Program. The study shows that the project rendered meaningful results as to the development of writing hypotheses among the children who had access to the program. We also observed the opinions of the teachers involved in the project, who mentioned that ALFABETO motivated students to develop their reading, writing and oral skills, and promoted socialization and interaction among students.

  18. An effectiveness analysis of a developed differentiated program for dancer’s motor quality development at the stage of specialized basic training

    Directory of Open Access Journals (Sweden)

    Tetiana Trakaliuk

    2017-08-01

    Full Text Available Purpose: practical substantiation of the effectiveness of using the developed differentiated program for the development of motor qualities of skilled dancers in sports dances at the stage of specialized basic training. Material & Methods: in the study involved 30 athletes, dancers aged 14–18 years who were engaged in a differentiated program for the development of motor qualities (experimental group and the generally accepted program of a sports and dance club (control group. Methods: analysis and generalization of information of special literature, method of pedagogical observation, method of pedagogical experiment, method of pedagogical testing, method of mathematical statistics. Result: analysis of the state of special physical preparation of dancers before and after using the developed differentiated program for the development of motor qualities is presented and obtained results of the values of the indices of their leading motor qualities. Conclusion: the efficiency of application of the developed differentiated program for the development of motor qualities of qualified dancers has been proved at the stage of specialized basic training.

  19. Breast and cervical cancers diagnosed and stage at diagnosis among women served through the National Breast and Cervical Cancer Early Detection Program.

    Science.gov (United States)

    Miller, Jacqueline W; Royalty, Janet; Henley, Jane; White, Arica; Richardson, Lisa C

    2015-05-01

    To assess cancers diagnosed and the stage of cancer at the time of diagnosis among low-income, under-insured, or uninsured women who received services through the National Breast and Cervical Cancer Early Detection Program (NBCCEDP). Using the NBCCEDP database, we examined the number and percent of women diagnosed during 2009-2011 with in situ breast cancer, invasive breast cancer, and invasive cervical cancer by demographic and clinical characteristics, including age, race and ethnicity, test indication (screening or diagnostic), symptoms (for breast cancer), and screening history (for cervical cancer). We examined these characteristics by stage at diagnosis, a new variable included in the database obtained by linking with state-based central cancer registries. There were 11,569 women diagnosed with invasive breast cancer, 1,988 with in situ breast cancer, and 583 with invasive cervical cancer through the NBCCEDP. Women who reported breast symptoms or who had diagnostic mammography were more likely to be diagnosed with breast cancer, and at a later stage, than those who did not have symptoms or who had screening mammography. Women who had been rarely or never screened for cervical cancer were more likely to be diagnosed with cervical cancer, and at a later stage, than women who received regular screenings. Women served through the NBCCEDP who have not had prior screening or who have symptoms were more often diagnosed with late-stage disease.

  20. Knowledge, skills, and behavior improvements on peer educators and low-income Hispanic participants after a stage of change-based bilingual nutrition education program.

    Science.gov (United States)

    Taylor, T; Serrano, E; Anderson, J; Kendall, P

    2000-06-01

    A nutrition education program, entitled La Cocina Saludable, was designed according to the Stage of Change Model and implemented in ten southern Colorado counties. The objectives were to improve the nutrition related knowledge, skills, and behaviors that lead to healthy lifestyles in a low-income Hispanic population. The content of the program included nutrition information designed to help mothers of preschool children provide for their children's nutritional needs. Previous studies suggest that low-income Hispanics often demonstrate low intakes of vitamins A and C, calcium, iron, and protein, and high rates of diabetes, obesity, and infections. Additionally, this population presents many obstacles for nutrition educators including limited resources, child care, transportation, time, language, culture, literacy, health beliefs, and, in some cases, the transient nature of the population. The program attempted to overcome these barriers by incorporating a flexible program format carried out by abuela (Hispanic grandmother) educators using the processes described in the Stage of Change Model. The program was evaluated using a knowledge, skills and behavior pre-test, post-test, and six-month follow-up survey on both the abuela educators as well as the actual class participants. Results of the peer education training sessions suggest that this type of training program can be effective in increasing the knowledge, skills, and behavior of peer educators as well as reduce need for retraining for educators who continuously teach classes. Additionally, the results suggest that this type of program can be effective in changing selected nutrition related knowledge, skills, and behaviors leading to healthy lifestyles for low-income Hispanic mothers of preschool children.

  1. A two-stage mixed-integer fuzzy programming with interval-valued membership functions approach for flood-diversion planning.

    Science.gov (United States)

    Wang, S; Huang, G H

    2013-03-15

    Flood disasters have been extremely severe in recent decades, and they account for about one third of all natural catastrophes throughout the world. In this study, a two-stage mixed-integer fuzzy programming with interval-valued membership functions (TMFP-IMF) approach is developed for flood-diversion planning under uncertainty. TMFP-IMF integrates the fuzzy flexible programming, two-stage stochastic programming, and integer programming within a general framework. A concept of interval-valued fuzzy membership function is introduced to address complexities of system uncertainties. TMFP-IMF can not only deal with uncertainties expressed as fuzzy sets and probability distributions, but also incorporate pre-regulated water-diversion policies directly into its optimization process. TMFP-IMF is applied to a hypothetical case study of flood-diversion planning for demonstrating its applicability. Results indicate that reasonable solutions can be generated for binary and continuous variables. A variety of flood-diversion and capacity-expansion schemes can be obtained under four scenarios, which enable decision makers (DMs) to identify the most desired one based on their perceptions and attitudes towards the objective-function value and constraints. Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. Simulator program as a form of implementation of electronic teaching tools for self-study of foreign students at the stage of pre-university training

    Directory of Open Access Journals (Sweden)

    Andriy O. Savel'ev

    2015-06-01

    Full Text Available Questions of empowerment the organization of classroom and extracurricular self-study of foreign students at the stage of pre-university training through the implementation of electronic teaching tools as a component of computer training facilities in educational process are considered. Classification of modern electronic teaching tools as a component of computer hardware training, developed on the basis of modern information and communication technologies is offered. Version of program-simulator "Introductory course" is offered. The program is created by means of WEB-programming and uses training material of introductory course. Introductory course is one of the most important elements of teaching of scientific style of speech within the language training for the foreign students at the preparatory faculty.

  3. Making a difference: Ten case studies of DSM/IRP interactive efforts and related advocacy group activities

    Energy Technology Data Exchange (ETDEWEB)

    English, M.; Schexnayder, S.; Altman, J. [Tennessee Univ., Knoxville, TN (United States). Energy, Environment and Resources Center; Schweitzer, M. [Oak Ridge National Lab., TN (United States)

    1994-03-01

    This report discusses the activities of organizations that seek to promote integrated resource planning and aggressive, cost-effective demand-side management by utilities. The activities of such groups -- here called energy efficiency advocacy groups (EEAGs) -- are examined in ten detailed am studies. Nine of the cases involve some form of interactive effort between investor-owned electric utilities and non-utility to develop policies, plans, or programs cooperatively. Many but not all of the interactive efforts examined are formal collaboratives. In addition, all ten cases include discussion of other EEAG activities, such as coalition-building, research, participation in statewide energy planning, and intervention in regulatory proceedings.

  4. ANALYSIS OF THE IMPLEMENTATION OF THE THIRD STAGE OF SUBPROGRAM «DEVELOPMENT AND USE OF THE ARCTIC REGION» OF THE FEDERAL TARGET PROGRAM «WORLD OCEAN»

    Directory of Open Access Journals (Sweden)

    V. Merkulov

    2015-01-01

    Full Text Available This article contains analysis of the implementation of the third stage of subprogram «Development and use of Arctic region» of the federal target program «World ocean». Following areas of subprogram were analyzed during the research: capital investments, research and development, «other needs» article, level of fi nancing and means of subprogram’s results evaluation. Also method of weight coefficients was used for assessment of subprogram’s eff ectiveness and adjustments for subprogram system of management were proposed based on results of the research.

  5. Student Perceptions of Staged Transfer to Independent Research Skills during a Four-Year Honours Science Undergraduate Program

    Science.gov (United States)

    Symons, Sarah L.; Colgoni, Andrew; Harvey, Chad T.

    2017-01-01

    We describe interim results of an ongoing longitudinal pedagogical study investigating the efficacy of the Honours Integrated Science Program (iSci). We describe the pedagogical methods we use to prompt research skill development in a model from instructor-dependence to independent original research. We also describe a tool we use to help students…

  6. Interactive efforts to address DSM and IRP issues: Findings from the first year of a two-year study

    Energy Technology Data Exchange (ETDEWEB)

    Schweitzer, M. [Oak Ridge National Lab., TN (United States); English, M.; Altman, J. [Tennessee Univ., Knoxville, TN (United States). Energy, Environment and Resources Center; Yourstone, E. [Consultant, Albuquerque, NM (United States)

    1993-04-01

    This report presents findings from the first year of a two-year study of interactive efforts involving utilities and non-utility parties (NUPS) working together to prepare plans, develop Demand-Side Management (DSM) programs, or otherwise promote integrated planning and the use of cost-effective DSM measures. Of the ten cases covered in the current study, seven involved the collaborative approach to NUP involvement, which generally is marked by intensive utility-NUP interactions designed to reach consensus on a broad range of important issues; in collaboratives, outside consultants often are provided to enhance the technical capabilities of the NUPS. Another of the cases in this study involved a ``cooperative arrangement,`` whereby a utility and a NLT worked together in a focused short-term effort to develop a single DSM program. The intense interaction involved in this approach makes it very similar to a collaborative, except that both the scope and the duration of the effort were much more limited than in a normal collaborative. The ninth case concerned a task force run by state regulatory staff that was charged with the limited job of studying various cost-effectiveness tests available for assessing prospective DSM measures. All of these approaches (collaborative, cooperative arrangement, and task force) are types of interactive effort, as that term is used in this report. The final case concerned NUPs` attempts to encourage greater utility use of DSM in Florida but, to date, no interactive effort has been initiated there. Three main features of interactive efforts are described in this report: (1) the participants involved; (2) the context in which the efforts took place; and (3) key characteristics of the interactive process. This report also examines the outcomes achieved by the interactive efforts. These outcomes can be divided into two general categories: Product-related and participant-related.

  7. Interactive efforts to address DSM and IRP issues: Findings from the first year of a two-year study

    Energy Technology Data Exchange (ETDEWEB)

    Schweitzer, M. (Oak Ridge National Lab., TN (United States)); English, M.; Altman, J. (Tennessee Univ., Knoxville, TN (United States). Energy, Environment and Resources Center); Yourstone, E. (Consultant, Albuquerque, NM (United States))

    1993-04-01

    This report presents findings from the first year of a two-year study of interactive efforts involving utilities and non-utility parties (NUPS) working together to prepare plans, develop Demand-Side Management (DSM) programs, or otherwise promote integrated planning and the use of cost-effective DSM measures. Of the ten cases covered in the current study, seven involved the collaborative approach to NUP involvement, which generally is marked by intensive utility-NUP interactions designed to reach consensus on a broad range of important issues; in collaboratives, outside consultants often are provided to enhance the technical capabilities of the NUPS. Another of the cases in this study involved a cooperative arrangement,'' whereby a utility and a NLT worked together in a focused short-term effort to develop a single DSM program. The intense interaction involved in this approach makes it very similar to a collaborative, except that both the scope and the duration of the effort were much more limited than in a normal collaborative. The ninth case concerned a task force run by state regulatory staff that was charged with the limited job of studying various cost-effectiveness tests available for assessing prospective DSM measures. All of these approaches (collaborative, cooperative arrangement, and task force) are types of interactive effort, as that term is used in this report. The final case concerned NUPs' attempts to encourage greater utility use of DSM in Florida but, to date, no interactive effort has been initiated there. Three main features of interactive efforts are described in this report: (1) the participants involved; (2) the context in which the efforts took place; and (3) key characteristics of the interactive process. This report also examines the outcomes achieved by the interactive efforts. These outcomes can be divided into two general categories: Product-related and participant-related.

  8. Effects of an osteoporosis prevention training program on physical activity-related stages of change and self-efficacy among university students, Shiraz, Iran: a Randomized Clinical Trial.

    Science.gov (United States)

    Kaveh, Mohammad Hossien; Golij, Monire; Nazari, Mahin; Mazloom, Zohreh; Rezaeian Zadeh, Abbas

    2014-10-01

    Osteoporosis is a major problem in today's world, being characterized by decreased bone mass and bone change. Due to deficiency of theory-based studies in young population, especially in students, there are significant knowledge gaps of effective planning. Thepresent study was performed in response to this need. The present study investigated the effect of an empowerment program on physical activity related stages of change and self-efficacyin preventing osteoporosis among university students. In this randomized controlled trial (IRCT: IRCT201212016261N2), 152 female students of Shiraz University of Medical Sciences were selected through multi-stages cluster sampling and were randomly assigned to an experimental (n=76) and a control (n=76) group.The pre-and post-intervention data were collected using the Stages of Exercise Change Questionnaire (SECQ) of Marcos with Cronbach's alpha reliability of 0.89 and also the self-efficacy scale with a Cronbach's alpha reliability of 0.88 and Test-Retest Correlation Coefficient of 0.80. The educational intervention for the experimental group took place through problem-based learning method, small group discussion, and training manuals. In addition, training CDs and brochures were given to the subjects and short SMSs were sent to them. The data were analyzed throughSPSS, version 14, usingMann-Whitney test, Chi-square test, Wilcoxon and regression tests. Pre-intervention findings showed that participants had behavioral constructs below the expected levels. The results showed that the experimental group received significant statisticalincrease after the intervention in stage of change. Before the intervention, the mean scores of stages of changes in the experimental groups was 2.28±0.86 but this rose to 3±0.84 in the first post-test and 3.22±0.84 in the second post-test. The control group showed a significant increase in stage of change without intervention (pre-test 2.04±0.82, first post-test 2.18±0.87 and second post

  9. PERIODIC REVIEW SYSTEM FOR INVENTORY REPLENISHMENT CONTROL FOR A TWO-ECHELON LOGISTICS NETWORK UNDER DEMAND UNCERTAINTY: A TWO-STAGE STOCHASTIC PROGRAMING APPROACH

    Directory of Open Access Journals (Sweden)

    P.S.A. Cunha

    Full Text Available ABSTRACT Here, we propose a novel methodology for replenishment and control systems for inventories of two-echelon logistics networks using a two-stage stochastic programming, considering periodic review and uncertain demands. In addition, to achieve better customer services, we introduce a variable rationing rule to address quantities of the item in short. The devised models are reformulated into their deterministic equivalent, resulting in nonlinear mixed-integer programming models, which are then approximately linearized. To deal with the uncertain nature of the item demand levels, we apply a Monte Carlo simulation-based method to generate finite and discrete sets of scenarios. Moreover, the proposed approach does not require restricted assumptions to the behavior of the probabilistic phenomena, as does several existing methods in the literature. Numerical experiments with the proposed approach for randomly generated instances of the problem show results with errors around 1%.

  10. Tool for evaluating the evolution Space Weather Regional Warning Centers under the innovation point of view: the Case Study of the Embrace Space Weather Program Early Stages

    Science.gov (United States)

    Denardini, Clezio Marcos

    2016-07-01

    We have developed a tool for measuring the evolutional stage of the space weather regional warning centers using the approach of the innovative evolution starting from the perspective presented by Figueiredo (2009, Innovation Management: Concepts, metrics and experiences of companies in Brazil. Publisher LTC, Rio de Janeiro - RJ). It is based on measuring the stock of technological skills needed to perform a certain task that is (or should) be part of the scope of a space weather center. It also addresses the technological capacity for innovation considering the accumulation of technological and learning capabilities, instead of the usual international indices like number of registered patents. Based on this definition, we have developed a model for measuring the capabilities of the Brazilian Study and Monitoring Program Space Weather (Embrace), a program of the National Institute for Space Research (INPE), which has gone through three national stages of development and an international validation step. This program was created in 2007 encompassing competence from five divisions of INPE in order to carry out the data collection and maintenance of the observing system in space weather; to model processes of the Sun-Earth system; to provide real-time information and to forecast space weather; and provide diagnostic their effects on different technological systems. In the present work, we considered the issues related to the innovation of micro-processes inherent to the nature of the Embrace program, not the macro-economic processes, despite recognizing the importance of these. During the development phase, the model was submitted to five scientists/managers from five different countries member of the International Space Environment Service (ISES) who presented their evaluations, concerns and suggestions. It was applied to the Embrace program through an interview form developed to be answered by professional members of regional warning centers. Based on the returning

  11. Installation Restoration Program Stage 2-1 Remedial Investigation. Beale Air Force Base, Marysville, California. Volume 1. Text and Plates

    Science.gov (United States)

    1991-03-29

    ABSTRACT ( Coen n mIvvrsg of new y &V AW n by blad anfbw) As part of the ongoing Installation Restoration Program at Beale Air Force Base, California, 24...detected at the same depths at 0.005 (be- low LOQ), 0.014, 0.006, and 0.21 mg/kg. 1,1,2 trichloro- ethane was detected at 0.009 mg/kg at 48 feet (42

  12. Teen Dating Violence Prevention: Cluster-Randomized Trial of Teen Choices, an Online, Stage-Based Program for Healthy, Nonviolent Relationships.

    Science.gov (United States)

    Levesque, Deborah A; Johnson, Janet L; Welch, Carol A; Prochaska, Janice M; Paiva, Andrea L

    2016-07-01

    Teen dating violence is a serious public health problem. A cluster-randomized trial was conducted to assess the efficacy of Teen Choices, a 3-session online program that delivers assessments and individualized guidance matched to dating history, dating violence experiences, and stage of readiness for using healthy relationship skills. For high risk victims of dating violence, the program addresses readiness to keep oneself safe in relationships. Twenty high schools were randomly assigned to the Teen Choices condition (n=2,000) or a Comparison condition (n=1,901). Emotional and physical dating violence victimization and perpetration were assessed at 6 and 12 months in the subset of participants (total n=2,605) who reported a past-year history of dating violence at baseline, and/or who dated during the study. The Teen Choices program was associated with significantly reduced odds of all four types of dating violence (adjusted ORs ranging from .45 to .63 at 12 months follow-up). For three of the four violence outcomes, participants with a past-year history of that type of violence benefited significantly more from the intervention than students without a past-year history. The Teen Choices program provides an effective and practicable strategy for intervention for teen dating violence prevention.

  13. [Effects of a smoking cessation program including telephone counseling and text messaging using stages of change for outpatients after a myocardial infarction].

    Science.gov (United States)

    Kong, Jung-Hyeon; Ha, Yeongmi

    2013-08-01

    This study was done to identify effects of a smoking cessation program including telephone counseling and text messaging using stages of change for outpatients who have had a myocardial infarction (MI). This research was a quasi-experimental design with a nonequivalent control group pretest-posttest. The participants were 48 outpatients (experimental group=24, control group=24) recruited from one university hospital. They were randomly assigned to one of two groups: (a) an experimental group with telephone counseling (once a week) and text messaging (five times a week) using stages of change, and (b) a control group with traditional telephone counseling (once a month). Efficacy of the intervention was measured by comparing the two groups on smoking-related variables at 3 weeks and 12 weeks. At the 3-week and 12-week measurements, there were significant differences between the experimental and control groups on smoking cessation self-efficacy (pstages of change is effective for outpatients after a MI. Further attention should be paid to the intensity of the smoking cessation program and periods for long-term follow-up.

  14. Early stage colon cancer

    National Research Council Canada - National Science Library

    Freeman, Hugh James

    2013-01-01

    .... After resection of malignant pedunculated colon polyps or early stage colon cancers, long-term repeated surveillance programs can also lead to detection and removal of asymptomatic high risk advanced...

  15. The role of stages in designing English syllabus development for the students of electrical engineering study program

    Science.gov (United States)

    Imron, Aly

    2017-09-01

    Developing syllabus is badly needed to anticipate the quick progress of the educational era and revision of the existing one when it is considered not to meet a demand of clearness, efficiency, and pedagogic view. Polytechnic education product goes professional worker`s candidate in the workplace. Therefore, the subject given is designed as proper as possible which is closely and in line with the job place. The research problem is stated with: what is the suitable English syllabus for the technical student by using communicative approach. The method used consists of some stages, namely: 1. Doing the needs survey; 2. Deciding the purpose of the course; 3. Choosing the syllabus type; 4. Writing the proto syllabus; 5. Writing syllabus product for the technical students; 6. Expect validation and revising; and 7. Implementation of class procedure and revising the final product. The research uses the questionnaire and interview for collecting the data. The result shows that the syllabus developed are appropriate based on the input from students, teachers, subject specialist, and reviewer.

  16. Preliminary assessment report for Camp Swift Military Reservation, Installation 48070, Bastrop County, Texas. Installation Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    Dennis, C.B.

    1993-08-01

    This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at the Texas Army National Guard property in Bastrop County, Texas. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The principal objective of the PA is to characterize the site accurately and determine the need for further action by examining site activities, quantities of hazardous substances present, and potential pathways by which contamination could affect public health and the environment. This PA satisfies, for the Camp Swift property, the requirement of the Department of Defense Installation Restoration Program (IRP). The review of both historical and current practices at the property indicated that the activities at Camp Swift include no operations considered to have an adverse impact to the environment. The recommendation, therefore, is that no further IRP action is necessary at this property.

  17. A home-based, nurse-led health program for postoperative patients with early-stage cervical cancer: A randomized controlled trial.

    Science.gov (United States)

    Li, Jue; Huang, Jiliang; Zhang, Jun; Li, Yajie

    2016-04-01

    To investigate the effect of a home-based, nurse-led health program on quality of life and family function for postoperative patients with early-stage cervical cancer. 226 cervical cancer patients, from two hospitals between December 2012 and April 2014, were randomly divided into intervention and control groups. Patients in the intervention group received an individual home-based, nurse-led health program (family-care team provision, physiological rehabilitation, emotion-release management, informal social support system, and follow-up monitoring), in addition to conventional nursing education. Patients in the control group only received conventional nursing education. The Functional Assessment Cancer Therapy-Cervix, Female Sexual Function Index, and the Family Adaptability and Cohesion Scale were used for assessment before and after the intervention. After the intervention, significant improvements were found for the quality of life total scores (t=-7.650, p=0.000), sexual function scores (t=-6.465, p=0.000), cohesion scores (t=-8.417, p=0.001) and adaptability scores (t=-10.735, p=0.000) in the intervention group. Moreover, proportions of family types were also improved (χ2 = 17.77, p=0.000). However, for the control group, no significant differences were found except for a decrease in sexual function scores (t = -4.035, p=0.000). Significant differences in change scores between groups were also found for quality of life (F=41.980, p=0.000), Sexual function (F=37.380, p=0.000), cohesion (F=15.268, p=0.000) and adaptability (F=16.998, p=0.000). A home-based, nurse-led health promotion program improves the quality of life, sexual function and family function in postoperative patients with early-stage cervical cancer. Copyright © 2015. Published by Elsevier Ltd.

  18. Installation restoration program (irp) remedial investigation/feasibility study, Kotzebue Long Range Radar Station, Alaska. Human health and ecological risk assessment. Final baseline report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    The purpose of the Baseline Human Health and Ecological Risk Assessment Report is to provide an assessment of the risk to human and ecological receptors from exposure to contaminants measured during the 1994 Remedial Investigation at Kotzebue Long Range Radar Station, Alaska.

  19. Can a single "powerless" mitochondrion in the malaria parasite contribute to parasite programmed cell death in the asexual stages?

    Science.gov (United States)

    Ch'ng, Jun-Hong; Yeo, Su-Ping; Shyong-Wei Tan, Kevin

    2013-05-01

    The protozoan pathogens responsible for malaria are from the Plasmodium genus, with Plasmodium falciparum and Plasmodium vivax accounting for almost all clinical infections. With recent estimates of mortality exceeding 800,000 annually, malaria continues to take a terrible toll on lives and the early promises of medicine to eradicate the disease have yet to approach realization, in part due to the spread of drug resistant parasites. Recent reports of artemisinin-resistance have prompted renewed efforts to identify novel therapeutic options, and one such pathway being considered for antimalarial exploit is the parasite's programmed cell death (PCD) pathway. In this mini-review, we will discuss the roles of the plasmodium mitochondria in cell death and as a target of antimalarial compounds, taking into account recent data suggesting that PCD pathways involving the mitochondria may be attractive antimalarial targets. Copyright © 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

  20. The "Romsås in Motion" community intervention: program exposure and psychosocial mediated relationships to change in stages of change in physical activity

    Directory of Open Access Journals (Sweden)

    Jenum Anne

    2007-04-01

    Full Text Available Abstract Background Conducting process evaluations of health promoting interventions, and measuring the effectiveness of specific intervention components, may help in the understanding of program failure or success. The purposes of the present study were to examine adults' exposure to and involvement in specific components of a three year long pseudo-experimental community-based physical activity intervention, and to examine the relationship between such exposure and participation and changes in stages of change in physical activity and psychosocial mediators. Methods 1497 persons in the intervention group attended the baseline survey in 2000 (50.6% and 1204 (80.4 of baseline attendees provided data on the outcome variables of the present study. In 2003, 1089 were still living in the area, and were re-invited to follow-up assessments. Current analyses are based on the 603 persons (mean age 49 ± 10 years who provided baseline and follow-up data for the current purposes (56.6% follow-up rate. Process data, stages of change in physical activity, and potential psychosocial mediators of change in physical activity were assessed by questionnaires. The theory-based intervention was composed of communication, physical activity, environmental and participatory components. Data were analysed using frequency and descriptive statistics, Chi-square and t-tests, and regression analyses. Results Exposure and participation rates in the various intervention components varied greatly (1.5–92.7%. Participation in walking groups and aerobic exercise groups, as well as having seen the "Walk the stairs"-poster were significantly and positively related to change in stages of change in physical activity (β = .12, p = .011; β = .211, p Conclusion Findings revealed that particular intervention components, such as participation in physical activity groups, were more strongly related to forward transition in stages of change in physical activity than others. These

  1. Student Perceptions of Staged Transfer to Independent Research Skills During a Four-year Honours Science Undergraduate Program

    Directory of Open Access Journals (Sweden)

    Sarah L. Symons

    2017-03-01

    Full Text Available We describe interim results of an ongoing longitudinal pedagogical study investigating the efficacy of the Honours Integrated Science Program (iSci. We describe the pedagogical methods we use to prompt research skill development in a model from instructor-dependence to independent original research. We also describe a tool we use to help students organise their group research during their first attempts. Finally, we discuss students’ perceptions of how well iSci develops their research skills. Our results show that students are attracted to the iSci program because of the opportunities for research-based learning and skills development. We also found that in-program students value research skill development as a tool for successful completion of their degree and for their future academic or career plans. We conclude that our study methods help identify areas where we can support our students by building their research confidence and, in particular, their time-management skills. Nous présentons une description des résultats intérimaires d’une étude pédagogique longitudinale qui vise à évaluer l’efficacité du programme spécialisé intégré de sciences (iSci. Nous faisons une description des méthodes pédagogiques que nous utilisons pour déclencher le développement des compétences en recherche au sein d’un modèle qui va de la recherche qui dépend de l’instructeur à la recherche indépendante originale. Nous décrivons également un outil que nous utilisons pour aider les étudiants à organiser leur recherche par groupe au cours de leurs premières tentatives. Pour finir, nous discutons les perceptions des étudiants sur la manière dont le programme iSci développe leurs compétences en recherche. Nos résultats indiquent que les étudiants sont attirés vers le programme iSci à cause des occasions d’apprentissage basé sur la recherche et de développement des compétences. Nous avons également remarqué que les

  2. Staging Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    and lived as people are “staging themselves” (from below). Staging mobilities is a dynamic process between “being staged” (for example, being stopped at traffic lights) and the “mobile staging” of interacting individuals (negotiating a passage on the pavement). Staging Mobilities is about the fact...

  3. Trading stages

    DEFF Research Database (Denmark)

    Steiner, Uli; Tuljapurkar, Shripad; Coulson, Tim

    2012-01-01

    Interest in stage-and age structured models has recently increased because they can describe quantitative traits such as size that are left out of age-only demography. Available methods for the analysis of effects of vital rates on lifespan in stage-structured models have not been widely applied ...... examples. Much of our approach relies on trading of time and mortality risk in one stage for time and risk in others. Our approach contributes to the new framework of the study of age- and stage-structured biodemography....

  4. Liveness-enforcing supervisors synthesis for a class of generalised Petri nets based on two-stage deadlock control and mathematical programming

    Science.gov (United States)

    Zhao, Mi; Hou, Yifan; Liu, Ding

    2010-10-01

    In this article we deal with deadlock prevention problems for S4PR, a class of generalised Petri nets, which can well model a large class of flexible manufacturing systems where deadlocks are caused by insufficiently marked siphons. We present a deadlock prevention methodology that is an iterative approach consisting of two stages. The first one is called siphon control, which is to add for each insufficiently marked minimal siphon a control place to the original net. Its objective is to prevent a minimal siphon from being insufficiently marked. The second one, called control-induced siphon control, is to add a control place to the augmented net with its output arcs connecting to the source transitions, which assures that there are no new insufficiently marked siphons generated. At each iteration, a mixed integer programming approach is adopted for generalised Petri nets to obtain an insufficiently marked minimal siphon from the maximal deadly siphon. This way complete siphon enumeration is avoided that is much more time-consuming for a sizeable plant model than the proposed method. The relation of the proposed method and the liveness and reversibility of the controlled net is obtained. Examples are presented to demonstrate the presented method.

  5. Development and Lab-Scale Testing of a Gas Generator Hybrid Fuel in Support of the Hydrogen Peroxide Hybrid Upper Stage Program

    Science.gov (United States)

    Lund, Gary K.; Starrett, William David; Jensen, Kent C.; McNeal, Curtis (Technical Monitor)

    2001-01-01

    As part of a NASA funded contract to develop and demonstrate a gas generator cycle hybrid rocket motor for upper stage space motor applications, the development and demonstration of a low sensitivity, high performance fuel composition was undertaken. The ultimate goal of the development program was to demonstrate successful hybrid operation (start, stop, throttling) of the fuel with high concentration (90+%) hydrogen peroxide. The formulation development and lab-scale testing of a simple DOT Class 1.4c gas generator propellant is described. Both forward injected center perforated and aft injected end burner hybrid combustion behavior were evaluated with gaseous oxygen and catalytically decomposed 90% hydrogen peroxide. Cross flow and static environments were found to yield profoundly different combustion behaviors, which were further governed by binder type, oxidizer level and, significantly, oxidizer particle size. Primary extinguishment was accomplished via manipulation of PDL behavior and oxidizer turndown, which is enhanced with the hydrogen peroxide system. Laboratory scale combustor results compared very well with 11-inch and 24-inch sub-scale test results with 90% hydrogen peroxide.

  6. A decision rule based on goal programming and one-stage models for uncertain multi-criteria mixed decision making and games against nature

    Directory of Open Access Journals (Sweden)

    Helena Gaspars-Wieloch

    2017-01-01

    Full Text Available This paper is concerned with games against nature and multi-criteria decision making under uncertainty along with scenario planning. We focus on decision problems where a deterministic evaluation of criteria is not possible. The procedure we propose is based on weighted goal programming and may be applied when seeking a mixed strategy. A mixed strategy allows the decision maker to select and perform a weighted combination of several accessible alternatives. The new method takes into consideration the decision maker’s preference structure (importance of particular goals and nature (pessimistic, moderate or optimistic attitude towards a given problem. It is designed for one-shot decisions made under uncertainty with unknown probabilities (frequencies, i.e. for decision making under complete uncertainty or decision making under strategic uncertainty. The procedure refers to one-stage models, i.e. models considering combinations of scenarios and criteria (scenario-criterion pairs as distinct meta-attributes, which means that the novel approach can be used in the case of totally independent payoff matrices for particular targets. The algorithm does not require any information about frequencies, which is especially desirable for new decision problems. It can be successfully applied by passive decision makers, as only criteria weights and the coefficient of optimism have to be declared.

  7. Staging atmospheres

    DEFF Research Database (Denmark)

    Bille, Mikkel; Bjerregaard, Peter; Sørensen, Tim Flohr

    2015-01-01

    The article introduces the special issue on staging atmospheres by surveying the philosophical, political and anthropological literature on atmosphere, and explores the relationship between atmosphere, material culture, subjectivity and affect. Atmosphere seems to occupy one of the classic...

  8. Optimal land use management for soil erosion control by using an interval-parameter fuzzy two-stage stochastic programming approach.

    Science.gov (United States)

    Han, Jing-Cheng; Huang, Guo-He; Zhang, Hua; Li, Zhong

    2013-09-01

    Soil erosion is one of the most serious environmental and public health problems, and such land degradation can be effectively mitigated through performing land use transitions across a watershed. Optimal land use management can thus provide a way to reduce soil erosion while achieving the maximum net benefit. However, optimized land use allocation schemes are not always successful since uncertainties pertaining to soil erosion control are not well presented. This study applied an interval-parameter fuzzy two-stage stochastic programming approach to generate optimal land use planning strategies for soil erosion control based on an inexact optimization framework, in which various uncertainties were reflected. The modeling approach can incorporate predefined soil erosion control policies, and address inherent system uncertainties expressed as discrete intervals, fuzzy sets, and probability distributions. The developed model was demonstrated through a case study in the Xiangxi River watershed, China's Three Gorges Reservoir region. Land use transformations were employed as decision variables, and based on these, the land use change dynamics were yielded for a 15-year planning horizon. Finally, the maximum net economic benefit with an interval value of [1.197, 6.311] × 10(9) $ was obtained as well as corresponding land use allocations in the three planning periods. Also, the resulting soil erosion amount was found to be decreased and controlled at a tolerable level over the watershed. Thus, results confirm that the developed model is a useful tool for implementing land use management as not only does it allow local decision makers to optimize land use allocation, but can also help to answer how to accomplish land use changes.

  9. Acceptability of an internet cognitive behavioural therapy program for people with early-stage cancer and cancer survivors with depression and/or anxiety: thematic findings from focus groups.

    Science.gov (United States)

    Karageorge, A; Murphy, M J; Newby, J M; Kirsten, L; Andrews, G; Allison, K; Loughnan, S; Price, M; Shaw, J; Shepherd, H; Smith, J; Butow, P

    2017-07-01

    We developed an eight-lesson internet-delivered CBT (iCBT) program targeting anxiety and depression in early-stage cancer and cancer survivors. To explore the acceptability of the program, we showed volunteers the first two lessons and asked for their views. Focus groups (n = 3) and individual interviews (n = 5) were undertaken with 15 participants (11 survivors) with mainly breast (11 of the 15) cancer, who had reviewed intervention materials. Participants were asked to consider the acceptability of the iCBT program content and implementation design (timing, duration). Semi-structured questions guided discussion. Thematic analysis was conducted of participant reactions to the acceptability and/or suitability of materials created for use in a psychological intervention. We took a data-driven (inductive) approach to semantic theme development across the data set. Participants reported high acceptability of the internet delivery format, good engagement and user-friendly material. Participants were broadly supportive of combining depression and anxiety iCBT resources for early-stage cancer patients and survivors. Participants further indicated that a separate course would be needed to address the needs of patients with advanced stage disease. Participants welcomed the general development of an internet-delivered CBT intervention program to treat patients with clinical depression and/or anxiety. Furthermore, the sessions reviewed were highly acceptable to all participants. Study findings informed researchers on the development of iCBT resources for the cancer community.

  10. Effectiveness of the bowel management program in children with constipation secondary to anorectal malformations

    Directory of Open Access Journals (Sweden)

    Santos Jasso Karla A.

    2014-07-01

    Full Text Available Introduction: One thousand children with anorectal malformation (ARM are born in Mexico every year. In spite of surgical correction, these children continue to present functional fecal problems (constipation and fecal incontinence. We conducted an Intestinal Rehabilitation Program (IRP which consists of an initial rectal disimpaction followed by administration of stimulant-type laxative (senna, with favorable results. The objective of this paper is to describe the effectiveness of the Intestinal Rehabilitation Program/bowel management program (IRP/BMP in children with constipation secondary to surgically corrected ARM. Materials and methods: A descriptive, retrospective, cross-sectional study, describing which was the IRP effectiveness in children with constipation secondary to ARM. The effectiveness was measured by means of a construct of three variables (presence of daily bowel movements, absence of fecal staining, and having a plain abdominal radiograph without fecal residue in left colon and rectum after passing stool. All children who had surgically corrected ARM and constipation in two referral centers were included. Results. One hundred and fifty one children with ARM were included: 21.85% had fecal incontinence, and 67.33% had constipation. Of this group 88.1% showed good response to the BMP. The mean dose of sennoside was 8.45 mg/kg, 95% CI: 5.94-11.12 mg/kg (199.5 mg total dose, 95% CI: 139.50-259.50 mg. Colicky abdominal pain occurred in 5.8% of the patients. Discussion. The use of sennoside has had a positive impact on our patients by means of colonic and rectal emptying without fecal soiling. Key words: Constipation, Anorrectal Malformation, Bowel Managment Program, Sennoside.

  11. IRP Stage 2 remedial investigation/feasibility study, Appendices A through K and M through R, for Bomarc Missile Site, McGuire AFB, New Jersey. Final report, November 1989-May 1992

    Energy Technology Data Exchange (ETDEWEB)

    Watts, P.; Collins, D.

    1992-05-26

    This document contains appendices to the final RI/FS report for the BOMARC Missile Site, McGuire AFB, New Jersey. The BOMARC site became contaminated in 1960 as the result of a fire which partially consumed a nuclear warhead-equipped BOMARC missile. The purpose of the RI/FS report is to document the extent and magnitude of environmental contamination at the site, to assess risks to human health and the environment, to determine the need for site remediation, and to evaluate feasible remedial alternatives. The appendices include borehole logs, analytical data, modeling information, etc.

  12. Difference of stage at cancer diagnosis by socioeconomic status for four target cancers of the National Cancer Screening Program in Korea: Results from the Gwangju and Jeonnam cancer registries.

    Science.gov (United States)

    Kweon, Sun-Seog; Kim, Min-Gyeong; Kang, Mi-Ran; Shin, Min-Ho; Choi, Jin-Su

    2017-07-01

    The aim of this study was to evaluate whether stage at cancer diagnosis differed according to patient economic status. A total of 10,528 patients with cancer of the stomach, colorectum, breast, or cervix, which are target organs of the Korean National Cancer Screening Program (NCSP; fully implemented in 2005) were extracted from population-based cancer registries. The patients were classified into four groups based on socioeconomic status (SES), as determined using their National Health Insurance (NHI) monthly premium at the time of cancer diagnosis. Cancer stage at diagnosis was defined as early (in situ/local) or late stage (regional/distant) based on the Surveillance, Epidemiology, and End Results (SEER) summary stage. Multivariable logistic regression analysis was performed to estimate the risk of non-local stage using age, residential area, and community deprivation index as covariates. The lowest SES subjects showed significantly higher risks of being diagnosed at a later stage for stomach, colorectal, and female breast cancer, but not for cervical cancer, compared with the highest SES subjects. The estimated ORs were 1.28 (95% CI, 1.10-1.49), 1.29 (95% CI, 1.03-1.61), and 1.35 (95% CI, 1.02-1.81) in the lowest SES subjects with stomach, colorectal, and breast cancer, respectively. In conclusion, later stage diagnoses of stomach, colon, and female breast cancer are still associated with SES in Korea in the era of the NCSP for the lower SES population. Copyright © 2017 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

  13. Installation Restoration Program (IRP). Site Investigation Report for IRP Sites Number 1 and Number 2. Volume 2: Appendices A-F. 162nd Combat Communications Group and 149th Combat Communications Squadron, California Air National Guard, North Highlands Air National Guard Station, Sacramento, California.

    Science.gov (United States)

    1995-09-01

    nI ) Vý4 f n t)t) W Id CL.- - - ’ A ’ ’ A ’ A ’ A ’ ’ A ’ A ’ A cc() 0,a LQ5 :EC)CLa -0 a K (1 c c 0C 2( (D 0 E jcz ro -L ’A 8f aA mA ’A cA E ’A A:sA

  14. Human Research Program Human Health Countermeasures Element Sensorimotor Risk Standing Review Panel (SRP) Final Report

    Science.gov (United States)

    Peterson, Barry

    2009-01-01

    The Sensorimotor Risk Standing Review Panel (SRP) met at the NASA Johnson Space Center on October 4-6, 2009 to discuss the areas of future research targeted by the Human Health Countermeasures (HHC) Element of the Human Research Program (HRP). Using evidence-based knowledge as a background for risks, NASA had identified gaps in knowledge to address those risks. Ongoing and proposed tasks were presented to address the gaps. The charge to the Sensorimotor Risk SRP was to review the gaps, evaluate whether the tasks addressed these gaps and to make recommendations to NASA s HRP Science Management Office regarding the SRP's review. The SRP was requested to evaluate the practicality of the proposed efforts in light of the realistic demands placed on the HRP. In short, all tasks presented in the Integrated Research Plan (IRP) should address specific risks related to the challenges faced by the astronauts as a result of prolonged exposure to microgravity. All tasks proposed to fill the gaps in knowledge should provide applied, translational data necessary to address the specific risks. Several presentations were made to the SRP during the site visit and the SRP spent sufficient time to address the panel charge, either as a group or in separate sessions. The SRP made a final debriefing to the HRP Program Scientist. Taking the evidence and the risk as givens, the SRP reached the following conclusions: 1) the panel is very supportive of and endorses the present activities of the Sensorimotor Risk; and the panel is likewise supportive of the gaps and associated tasks in the IRP; 2) overall, the tasks addressed the gaps in the IRP; 3) there were some gaps and tasks that merit further enhancement and some new gaps/tasks that the SRP recommends.

  15. The main provisions of the program on improvement technique of competitive actions qualified foil fencers at a stage of specialized basic training

    Directory of Open Access Journals (Sweden)

    Bakum A.V.

    2012-12-01

    Full Text Available A ground and program of perfection of technique of competition actions of skilled sportsmen is presented in setup and competition times of annual cycle of preparation. 14 sportsmen took part in an experiment. The program was based on programmatic-having a special purpose approach and included the models of competition actions. The program included the complexes of physical exercises, directed on perfection of basic elements of technique of attacking, protective and counter-attacking actions also. Program components are included by complexes: imitation, tricking into, specially-preparatory and competition physical exercises of the having a special purpose affecting separate elements of technique of battle actions. Gradual complication of terms of implementation of exercises is recommended without an opponent, with a conditional opponent, with a partner and individual lessons.

  16. Medicare Program; End-Stage Renal Disease Prospective Payment System, Coverage and Payment for Renal Dialysis Services Furnished to Individuals With Acute Kidney Injury, End-Stage Renal Disease Quality Incentive Program, Durable Medical Equipment, Prosthetics, Orthotics and Supplies Competitive Bidding Program Bid Surety Bonds, State Licensure and Appeals Process for Breach of Contract Actions, Durable Medical Equipment, Prosthetics, Orthotics and Supplies Competitive Bidding Program and Fee Schedule Adjustments, Access to Care Issues for Durable Medical Equipment; and the Comprehensive End-Stage Renal Disease Care Model. Final rule.

    Science.gov (United States)

    2016-11-04

    This rule updates and makes revisions to the End-Stage Renal Disease (ESRD) Prospective Payment System (PPS) for calendar year 2017. It also finalizes policies for coverage and payment for renal dialysis services furnished by an ESRD facility to individuals with acute kidney injury. This rule also sets forth requirements for the ESRD Quality Incentive Program, including the inclusion of new quality measures beginning with payment year (PY) 2020 and provides updates to programmatic policies for the PY 2018 and PY 2019 ESRD QIP. This rule also implements statutory requirements for bid surety bonds and state licensure for the Durable Medical Equipment, Prosthetics, Orthotics, and Supplies (DMEPOS) Competitive Bidding Program (CBP). This rule also expands suppliers' appeal rights in the event of a breach of contract action taken by CMS, by revising the appeals regulation to extend the appeals process to all types of actions taken by CMS for a supplier's breach of contract, rather than limit an appeal for the termination of a competitive bidding contract. The rule also finalizes changes to the methodologies for adjusting fee schedule amounts for DMEPOS using information from CBPs and for submitting bids and establishing single payment amounts under the CBPs for certain groupings of similar items with different features to address price inversions. Final changes also are made to the method for establishing bid limits for items under the DMEPOS CBPs. In addition, this rule summarizes comments on the impacts of coordinating Medicare and Medicaid Durable Medical Equipment for dually eligible beneficiaries. Finally, this rule also summarizes comments received in response to a request for information related to the Comprehensive ESRD Care Model and future payment models affecting renal care.

  17. The Navy’s Environmental Program and Opportunities in the Southwest

    Science.gov (United States)

    2013-08-27

    Achieve RIP for all High Priority IRP Sites FY14 •Achieve RC for 90% of IRP + MRP Sites FY18 •Achieve RC for 95% of IRP + MRP Sites FY21 9 NAVFAC Southwest...8/21/2013 ER,N IRP vs. MRP ($M) NAVFAC SW 0 10 20 30 40 50 60 70 FY 13 FY 14 FY 15 FY 16 FY 17 FY 18 FY 19 FY 20 FY 21 4 4 7 7 7 43 54 42 51...50 57 58 58 51 18 15 11 9 MRP IRP 10 NAVFAC Southwest Southwest ER,N Requirements Overall CTC: $766M ~54% IRP; ~46% MRP IRP , $411 MRP

  18. Economic evaluation of a multi-stage return to work program for workers on sick-leave due to low back pain

    NARCIS (Netherlands)

    Steenstra, I.A.; Anema, J.R.; Tulder, M.W. van; Bongers, P.M.; Vet, H.C.W. de; Mechelen, W. van

    2006-01-01

    Objective: To evaluate the cost-effectiveness and cost-utility of a return to work (RTW) program for workers on sick-leave due to low back pain (LBP), comparing a workplace intervention implemented between 2 to 8 weeks of sick-leave with usual care, and a clinical intervention after 8 weeks of

  19. The New Digital [St]age: Barriers to the Adoption and Adaptation of New Technologies to Deliver Extension Programming and How to Address Them

    Science.gov (United States)

    Seger, Jamie

    2011-01-01

    With the rise of social media and the need for statewide program cohesiveness, The Ohio State University Extension has the opportunity to position itself as a catalyst for technology adoption and adaptation nationwide. Unfortunately, many barriers exist to the successful use and implementation of technology, including an organizational structure…

  20. Adolescence as a critical stage in the MCH Life Course Model: commentary for the Leadership Education in Adolescent Health (LEAH) interdisciplinary training program projects.

    Science.gov (United States)

    Shlafer, Rebecca; Hergenroeder, Albert C; Jean Emans, S; Rickert, Vaughn I; Adger, Hoover; Spear, Bonnie; Irwin, Charles E; Kreipe, Richard E; Walker, Leslie R; Resnick, Michael D

    2014-02-01

    The Life Course Perspective (LCP), or Model, is now a guiding framework in Maternal and Child Health (MCH) activities, including training, supported by the Health Resources and Services Administration's Maternal and Child Health Bureau. As generally applied, the LCP tends to focus on pre- through post-natal stages, infancy and early childhood, with less attention paid to adolescents as either the "maternal" or "child" elements of MCH discourse. Adolescence is a distinct developmental period with unique opportunities for the development of health, competence and capacity and not merely a transitional phase between childhood and adulthood. Adequately addressing adolescents' emergent and ongoing health needs requires well-trained and specialized professionals who recognize the unique role of this developmental period in the LCP.

  1. Planning and implementing the first stage of an oral health program for the Pika Wiya Health Service Incorporated Aboriginal community in Port Augusta, South Australia.

    Science.gov (United States)

    Parker, Eleanor J; Misan, Gary; Richards, Lindsay C; Russell, Angela

    2005-01-01

    The oral health of the Indigenous community in South Australia's mid-north has been a concern for some years. There has been a history of under-utilisation of available dental services by the local community. This is in part due to the services not meeting their cultural and holistic health care needs. The Indigenous community resolved to establish a culturally sensitive dental service within the Aboriginal Health Service already operating in Port Augusta in South Australia's mid-north. To achieve this, a partnership between Pika Wiya Health Service Incorporated, the South Australian Dental Service, the University of Adelaide Dental School and the South Australian Centre for Rural and Remote Health was formed. The aim of the project partners was to establish a culturally sensitive, quality dental service that caters to the needs of the Indigenous community serviced by Pika Wiya Health Service Inc. This article describes the process of planning and implementing the first stage of this project.

  2. SPECIFIC SUBJECTS OF LICENSE ACADEMIC PROGRAM - AN IMPORTANT STAGE OF PROFESSIONAL DEVELOPMENT OF FUTURE MILITARY LEADERS AT NATIONAL MILITARY UNIVERSITY, BULGARIA

    Directory of Open Access Journals (Sweden)

    Elitsa Stoyanova PETROVA

    2016-09-01

    Full Text Available On the basis of an approved request by the Head of National Military University it is conducting research on motivation in military formations of the example of Vasil Levski National Military University in Veliko Tarnovo, Bulgaria. Subject of the study is motivation for training and military activities of the cadets and the objects of the study are students in professional military direction in "Organization and management of military units at the tactical level," Land forces faculty at the National Military University of Bulgaria. The article presents results of the study at second item - "Do you agree that the study of specialized topics is an important stage of your professional development of future military leader?". The interviewees were cadets who graduated through the following academic years - 2013/2014, 2014/2015, 2015/2016.

  3. The Application of Advanced Geophysical Classification in Support of Munitions Response Program: An Outreach to Federal, State and Local Regulators and Tribal Governments

    Science.gov (United States)

    2017-04-18

    FUDS Program CTC (FY* & Beyond) $ B ill io ns M&S IRP MMRP $18.2 $17.9 $16.7 $14.1 $14.0 $13.0 $13.5 $12.2 $10.0 $9.5 $3.2 $2.8 $3.0...collection, moderate geology Spencer Range, TN Camp Beale, CA Most analysts correctly classify all seeds, eliminate ~70% of the clutter from the...complex geology Massachusetts Military Reservation, MA Even the most skilled analysts may not detect all TOI, eliminate ~50- 70% of the clutter from

  4. Acceptability and preliminary feasibility of an internet/CD-ROM-based education and decision program for early-stage prostate cancer patients: randomized pilot study.

    Science.gov (United States)

    Diefenbach, Michael A; Mohamed, Nihal E; Butz, Brian P; Bar-Chama, Natan; Stock, Richard; Cesaretti, Jamie; Hassan, Waleed; Samadi, David; Hall, Simon J

    2012-01-13

    Prostate cancer is the most common cancer affecting men in the United States. Management options for localized disease exist, yet an evidence-based criterion standard for treatment still has to emerge. Although 5-year survival rates approach 98%, all treatment options carry the possibility for significant side effects, such as erectile dysfunction and urinary incontinence. It is therefore recommended that patients be actively involved in the treatment decision process. We have developed an Internet/CD-ROM-based multimedia Prostate Interactive Educational System (PIES) to enhance patients' treatment decision making. PIES virtually mirrors a health center to provide patients with information about prostate cancer and its treatment through an intuitive interface, using videos, animations, graphics, and texts. (1) To examine the acceptability and feasibility of the PIES intervention and to report preliminary outcomes of the program in a pilot trial among patients with a new prostate cancer diagnosis, and (2) to explore the potential impact of tailoring PIES treatment information to participants' information-seeking styles on study outcomes. Participants (n = 72) were patients with newly diagnosed localized prostate cancer who had not made a treatment decision. Patients were randomly assigned to 3 experimental conditions: (1) control condition (providing information through standard National Cancer Institute brochures; 26%), and PIES (2) with tailoring (43%) and (3) without tailoring to a patient's information-seeking style (31%). Questionnaires were administrated before (t1) and immediately after the intervention (t2). Measurements include evaluation and acceptability of the PIES intervention, monitoring/blunting information-seeking style, psychological distress, and decision-related variables (eg, decisional confidence, feeling informed about prostate cancer and treatment, and treatment preference). The PIES program was well accepted by patients and did not interfere

  5. Prostate cancer staging

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000397.htm Prostate cancer staging To use the sharing features on this ... trials you may be able to join How Prostate Cancer Staging is Done Initial staging is based on ...

  6. Control of stage by stage changing linear dynamic systems

    Directory of Open Access Journals (Sweden)

    Barseghyan V.R.

    2012-01-01

    Full Text Available In this paper, the control problems of linear dynamic systems stage by stage changing and the optimal control with the criteria of quality set for the whole range of time intervals are considered. The necessary and sufficient conditions of total controllability are also stated. The constructive solving method of a control problem is offered, as well as the definitions of conditions for the existence of programmed control and motions. The explicit form of control action for a control problem is constructed. The method for solving optimal control problem is offered, and the solution of optimal control of a specific target is brought.

  7. [Fundamental theory and practice in stroke rehabilitation from acute stage to chronic stage].

    Science.gov (United States)

    Hara, Hiroyoshi

    2011-11-01

    One of the most important objects of stroke rehabilitation is motor recovery from acute stage to chronic stage. Reorganization theory of motor circuits in the cerebral cortex contributing to recovery following stroke is proposed. In acute stage motor recovery depends on residual corticospinal tract excitability from onset to 3 months (1(st) stage recovery) . In next stage alternative output system is used according to intracortical excitability depending on intracortical disinhibition at the peak of 3 months (2(nd) stage recovery) . At 6 months and beyond training-induced synaptic strengthening becomes better established, and new networks are better reorganized (3(rd)stage recovery) . Stroke rehabilitation programs from acute stage are required depending on this stage theory. With each stage to select and perform the most effective rehabilitation programs are necessary. Two obstruction factors of motor recovery are indicated. One of them is Wallerian degeneration of corticospinal tract. Early Wallerian degeneration of the corticospinal tract that is seen on diffusion weighted MRI was reported. The appearance of Wallerian degeneration at acute stage should be directed to more attention as motor recovery inhibition. Next obstruction factor is development of spasticity from acute stage. Spastic paresis is subjected over time to immobilization of the paretic body part and chronic disuse of the paretic body part, which are avoidable through early rehabilitation intervention. Recently various interventions were proposed for motor recovery. The combination of repetitive transcranial magnetic stimulation and intensive occupational therapy by Abo (2010) are recommended to recovery hand function at chronic stage as 3(rd) stage recovery.

  8. Between Stage and Screen

    NARCIS (Netherlands)

    Tornqvist, Egil

    1996-01-01

    Ingmar Bergman is worldwide known as a film and stage director. Yet no-one has attempted to compare his stage and screen activities. In Between stage and screen Egil Tornqvist examines formal and thematical correspondences and differences between a number of Bergman's stage, screen, and radio

  9. The construction of two-stage tests

    NARCIS (Netherlands)

    Adema, Jos J.

    1988-01-01

    Although two-stage testing is not the most efficient form of adaptive testing, it has some advantages. In this paper, linear programming models are given for the construction of two-stage tests. In these models, practical constraints with respect to, among other things, test composition,

  10. Stages of Adolescence

    Science.gov (United States)

    ... Español Text Size Email Print Share Stages of Adolescence Page Content Article Body Adolescence, these years from puberty to adulthood, may be roughly divided into three stages: early adolescence, generally ages eleven to fourteen; middle adolescence, ages ...

  11. Ages and Stages: Teen

    Science.gov (United States)

    ... Pediatrician Ages & Stages Prenatal Baby Toddler Preschool Gradeschool Teen Dating & Sex Fitness Nutrition Driving Safety School Substance Use Young Adult Healthy Children > Ages & Stages > Teen Teen Article Body Adolescence can be a rough ...

  12. Breast cancer staging

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000911.htm Breast cancer staging To use the sharing features on this ... Once your health care team knows you have breast cancer , they will do more tests to stage it. ...

  13. Preliminary assessment report for Army Aviation Support Facility No. 3, Installation 13307, Hunter Army Airfield, Savannah, Georgia. Installation Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    Kolpa, R.; Smith, K.

    1993-07-01

    This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at the Georgia Army National Guard property located on Hunter Army Airfield (HAA) near Savannah, Georgia, known as Army Aviation Support Facility (AASF) No. 3. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The principal objective of the PA is to characterize the site accurately and determine the need for further action by examining site activities, types and quantities of hazardous substances utilized, the nature and amounts of wastes generated or stored at the facility, and potential pathways by which contamination could affect public health and the environment. This PA satisfies, for the AASF No. 3 property, requirements of the Department of Defense Installation Restoration Program (IRP). The scope of this assessment is limited to the facilities and past activities contained within the area now occupied by AASF No. 3. However, this assessment report is intended to be read in conjunction with a previous IRP assessment of HAA completed in 1992 (USATHAMA 1992) and to provide comprehensive information on AASF No. 3 for incorporation with information contained in that previous assessment for the entirety of HAA.

  14. Staging of Lung Cancer

    Science.gov (United States)

    ... LUNG CANCER MINI-SERIES #2 Staging of Lung Cancer Once your lung cancer is diagnosed, staging tells you and your health care provider about ... at it under a microscope. The stages of lung cancer are listed as I, II, III, and IV ...

  15. Pancreatic Cancer Stage 3

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Pancreatic Cancer Stage 3 Add to My Pictures View /Download : ... 1500x1200 View Download Large: 3000x2400 View Download Title: Pancreatic Cancer Stage 3 Description: Stage III pancreatic cancer; drawing ...

  16. Pancreatic Cancer Stage 4

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Pancreatic Cancer Stage 4 Add to My Pictures View /Download : ... 1200x1200 View Download Large: 2400x2400 View Download Title: Pancreatic Cancer Stage 4 Description: Stage IV pancreatic cancer; drawing ...

  17. Beyond Erikson's Eight Stages.

    Science.gov (United States)

    Whitney, Ruth

    1979-01-01

    Erik Erikson has described eight stages of the healthy personality. This essay offers a revised version of the eight stages. Although most individuals develop through the eight stages, each is personally unique because patterns of fluctuation between safety and growth differ from one individual to another. (Author)

  18. Validity, reliability, and feasibility of clinical staging scales in dementia: a systematic review

    DEFF Research Database (Denmark)

    Rikkert, Marcel G M Olde; Tona, Klodiana Daphne; Janssen, Lieneke

    2011-01-01

    New staging systems of dementia require adaptation of disease management programs and adequate staging instruments. Therefore, we systematically reviewed the literature on validity and reliability of clinically applicable, multidomain, and dementia staging instruments. A total of 23 articles desc...

  19. Simulation and comparison of equilibrium and nonequilibrium stage ...

    African Journals Online (AJOL)

    In the present study, two distinctly different approaches are followed for modelling of reactive distillation column, the equilibrium stage model and the nonequilibrium stage model. These models are simulated with a computer code developed in the present study using MATLAB programming. In the equilibrium stage models, ...

  20. Multiple Stages 2

    DEFF Research Database (Denmark)

    Andreasen, John

    Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations......Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations...

  1. The US Support Program Assistance to the IAEA Safeguards Information Technology, Collection, and Analysis 2008

    Energy Technology Data Exchange (ETDEWEB)

    Tackentien,J.

    2008-06-12

    One of the United States Support Program's (USSP) priorities for 2008 is to support the International Atomic Energy Agency's (IAEA) development of an integrated and efficient safeguards information infrastructure, including reliable and maintainable information systems, and effective tools and resources to collect and analyze safeguards-relevant information. The USSP has provided funding in support of this priority for the ISIS Re-engineering Project (IRP), and for human resources support to the design and definition of the enhanced information analysis architecture project (nVision). Assistance for several other information technology efforts is provided. This paper will report on the various ongoing support measures undertaken by the USSP to support the IAEA's information technology enhancements and will provide some insights into activities that the USSP may support in the future.

  2. Preliminary assessment report for Waiawa Gulch, Installation 15080, Pearl City, Oahu, Hawaii. Installation Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    1993-08-01

    This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at the Hawaii Army National Guard (HIARNG) property near Pearl City, Oahu, Hawaii. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The principal objective of the PA is to characterize the site accurately and determine the need for further action by examining site activities, quantities of hazardous substances present, and potential pathways by which contamination could affect public health and the environment. This PA satisfies, for the Waiawa Gulch property, phase I of the Department of Defense Installation Restoration Program (IRP).

  3. 7 CFR 4274.332 - Post award requirements.

    Science.gov (United States)

    2010-01-01

    ... IRP loan, it need not establish and maintain a separate IRP revolving loan fund for each loan; it may... Program (IRP) § 4274.332 Post award requirements. (a) Applicability. Intermediaries receiving loans under this program shall be governed by these regulations, the loan agreement, the approved work plan...

  4. Understanding cancer staging

    Science.gov (United States)

    ... Manual and Handbook . 2nd ed. New York, NY: Springer; 2012. National Cancer Institute. Staging. Updated March 9, ... medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- ...

  5. stage/page/play

    DEFF Research Database (Denmark)

    stage/page/play is an anthology written by scholars coming from a broad range of academic backgrounds. Drawing on disciplines such as rhetoric, theology, philosophy, and anthropology, the articles all seek to explore new approaches to theatre and theatricality. stage analyzes the theatre as a uni......stage/page/play is an anthology written by scholars coming from a broad range of academic backgrounds. Drawing on disciplines such as rhetoric, theology, philosophy, and anthropology, the articles all seek to explore new approaches to theatre and theatricality. stage analyzes the theatre...... as a unique platform for aesthetic examinations of contemporary, cultural and political issues. page focuses on the drama text in a scenic, performative context, and on innovative dramaturgical strategies. play studies how theatricality comes into play in our everyday life in a broad popular and ritual...

  6. Staging Mobilities / Designing Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    2015-01-01

    asks: what are the physical, social, technical, and cultural conditions to the staging of contemporary urban mobilities? The theoretical framing in the Staging mobilities book is applied to four in-depth cases in the accompanying volume Designing mobilities.This book explore how places, sites......In recent years, urban research has taken a ‘mobilities turn’. There has been a developing realisation that mobilities do not ‘just happen.’ Mobilities are carefully and meticulously designed, planned and staged (from above). However, they are equally importantly acted out, performed and lived......, and systems 'hosting' these multiple and complex mobilities are designed and how they are staging these in terms of their physical layout. By analysing specific cases of ‘mobilities design’ related to the four modes of moving; Walk, Bike, Train, and Car, the book uncover important and until now neglected...

  7. Bioimpedance Spectroscopy in Detecting Lower-Extremity Lymphedema in Patients With Stage I, Stage II, Stage III, or Stage IV Vulvar Cancer Undergoing Surgery and Lymphadenectomy

    Science.gov (United States)

    2017-05-03

    Lymphedema; Perioperative/Postoperative Complications; Stage IA Vulvar Cancer; Stage IB Vulvar Cancer; Stage II Vulvar Cancer; Stage IIIA Vulvar Cancer; Stage IIIB Vulvar Cancer; Stage IIIC Vulvar Cancer; Stage IVA Vulvar Cancer; Stage IVB Vulvar Cancer

  8. Stages of change.

    Science.gov (United States)

    Norcross, John C; Krebs, Paul M; Prochaska, James O

    2011-02-01

    The transtheoretical model, in general, and the stages of change, in particular, have proven useful in adapting or tailoring treatment to the individual. We define the stages and processes of change and then review previous meta-analyses on their interrelationship. We report an original meta-analysis of 39 studies, encompassing 8,238 psychotherapy patients, to assess the ability of stages of change and related readiness measures to predict psychotherapy outcomes. Clinically significant effect sizes were found for the association between stage of change and psychotherapy outcomes (d = .46); the amount of progress clients make during treatment tends to be a function of their pretreatment stage of change. We examine potential moderators in effect size by study outcome, patient characteristics, treatment features, and diagnosis. We also review the large volume of behavioral health research, but scant psychotherapy research, that demonstrates the efficacy of matching treatment to the patient's stage of change. Limitations of the extant research are noted, and practice recommendations are advanced. © 2010 Wiley Periodicals, Inc.

  9. Composers on stage

    DEFF Research Database (Denmark)

    Groth, Sanne Krogh

    A trend on the scene of contemporary music is composers going on stage, performing their pieces themselves. Within a discourse of popular music, this is more the rule than exception, but when it comes to the context of contemporary scored music, the historical and aesthetic context differs...... to rise the following questions: What happens to the status of the author, when he suddenly (re-)appears on stage? How is this appearance to be understood in both a contemporary and historical context: Is it the musical virtuous appearing again, are we witnessing musical works turning......, and something quite different is undergoing. This paper intends to discuss three examples of performances in which the composer’s appearance on stage was an important part of the piece, - both when it came to the role as a performer and as an individual person – as representer and presenter. The paper intends...

  10. Staging Collaborative Innovation Processes

    DEFF Research Database (Denmark)

    Pedersen, Signe; Clausen, Christian

    and public private innovation partnerships. Based on a case study of a collaborative design process in a large electronics company the paper points to the key importance of staging and navigation of collaborative innovation process. Staging and navigation is presented as a combined activity: 1) to translate......Organisations are currently challenged by demands for increased collaborative innovation internally as well as with external and new entities - e.g. across the value chain. The authors seek to develop new approaches to managing collaborative innovative processes in the context of open innovation...

  11. Staged bilateral carotid endarterectomy

    DEFF Research Database (Denmark)

    Schroeder, T; Sillesen, H; Engell, Hans Christian

    1986-01-01

    In a series of 56 staged bilateral carotid endarterectomies, new neurologic symptoms developed in 5% and 20% following the first and second procedure, respectively. All complications were transient or minor. The incidence of postendarterectomy hypertension was significantly higher following...... the second procedure, when operations were staged less than 3 weeks apart. A correlation between these hypertensive episodes and the occurrence of new neurologic symptoms could not be shown. However, as this correlation has been proved in several other reports, bilateral carotid endarterectomy is advised...

  12. World Stage Design

    Index Scriptorium Estoniae

    2005-01-01

    12-19. III Torontos rahvusvaheline lavakujunduse, kostüümi ning valgus- ja helikujunduse näitus, mis toimub samaaegselt OISTATi (International Organization of Scenographers, Theatre Architects and Technicians) maailmakongressiga ja USITT (United States Institute for Theatre Technology) üritustega (konverents, Stage Expo). Eestit esindab lavakujunduse kategoorias Lilja Blumenfeld-Luhse

  13. Incontinentia Pigmenti Stage - II

    Directory of Open Access Journals (Sweden)

    Monan B Gharpumy

    1987-01-01

    Full Text Available Eight weeks old female child with linear verruc,ous lesions on edtemities, eosinohilia and characteristic calcified dyskeratotic cells on histopathological examination confirming the diagnosis of second stage of incontinentia pigmenti is reported. Brief account of genetic counselling is given.′

  14. Composites for Exploration Upper Stage

    Science.gov (United States)

    Fikes, J. C.; Jackson, J. R.; Richardson, S. W.; Thomas, A. D.; Mann, T. O.; Miller, S. G.

    2016-01-01

    The Composites for Exploration Upper Stage (CEUS) was a 3-year, level III project within the Technology Demonstration Missions program of the NASA Space Technology Mission Directorate. Studies have shown that composites provide important programmatic enhancements, including reduced weight to increase capability and accelerated expansion of exploration and science mission objectives. The CEUS project was focused on technologies that best advanced innovation, infusion, and broad applications for the inclusion of composites on future large human-rated launch vehicles and spacecraft. The benefits included near- and far-term opportunities for infusion (NASA, industry/commercial, Department of Defense), demonstrated critical technologies and technically implementable evolvable innovations, and sustained Agency experience. The initial scope of the project was to advance technologies for large composite structures applicable to the Space Launch System (SLS) Exploration Upper Stage (EUS) by focusing on the affordability and technical performance of the EUS forward and aft skirts. The project was tasked to develop and demonstrate critical composite technologies with a focus on full-scale materials, design, manufacturing, and test using NASA in-house capabilities. This would have demonstrated a major advancement in confidence and matured the large-scale composite technology to a Technology Readiness Level 6. This project would, therefore, have bridged the gap for providing composite application to SLS upgrades, enabling future exploration missions.

  15. Surveillance for Stage I Nonseminoma Testicular Cancer

    DEFF Research Database (Denmark)

    Daugaard, Gedske; Gundgaard, Maria Gry; Mortensen, Mette Saksø

    2014-01-01

    PURPOSE: To describe treatment results in a large cohort with stage I nonseminoma germ cell cancer (NSGCC) treated in a surveillance program. PATIENTS AND METHODS: From January 1, 1984, to December 31, 2007, 1,226 patients with stage I NSGCC, including high-risk patients with vascular invasion....... Relapses after 5 years were seen in 0.5% of the whole cohort or in 1.6% of relapsing patients. The majority of relapses (94.4%) belonged to the good prognostic group according to the International Germ Cell Cancer Collaborative Group classification. The disease-specific survival at 15 years was 99...

  16. Global Impact | FNLCR Staging

    Science.gov (United States)

    Through its direct support of clinical research, Frederick National Labactivities are not limited to national programs. The labis actively involved in more than 400 domestic and international studies related to cancer; influenza, HIV, Ebo

  17. Staging interrail mobilities

    DEFF Research Database (Denmark)

    Jensen, Martin Trandberg; Gyimóthy, Szilvia; Jensen, Ole B.

    2016-01-01

    This article applies the multiscalar ‘staging mobilities’ framework from the emergent subfield of mobilities design to analyse an enduring European rail travel phenomenon, interrail. This discussion extends and contributes to tourism mobilities research. Second, the article enriches previous...... and seat reservations. To reach these aims, the research design intertwines multi-sited ethnography, netnography, survey and interviews. The conclusion offers theoretical reflections pertaining to the role of mobilities designs and methodical hybrids in tourism mobilities research....

  18. Staging Sociotechnical Spaces

    DEFF Research Database (Denmark)

    Clausen, Christian; Yoshinaka, Yutaka

    2007-01-01

    The management of innovation and product development is increasingly facing complex challenges of staging design processes across heterogeneous organisational spaces, with multiple actor-concerns and sources of knowledge. This paper addresses how insights from the Actor-Network Theory and politic...... of product development. The concept of socio-technical spaces is further illustrated through actual examples from industry dealing with early conceptualisation in product development and the role played by management concepts in the configuration of spaces.......The management of innovation and product development is increasingly facing complex challenges of staging design processes across heterogeneous organisational spaces, with multiple actor-concerns and sources of knowledge. This paper addresses how insights from the Actor-Network Theory and political...... process theory may contribute to a reflexive understanding of design as the staging of socio-technical relations and processes cutting across boundaries of diverse organisational, political and knowledge domains. This idea is pursued through the notion of ‘socio-technical spaces’. Socio-technical space...

  19. Staged cascade fluidized bed combustor

    Science.gov (United States)

    Cannon, Joseph N.; De Lucia, David E.; Jackson, William M.; Porter, James H.

    1984-01-01

    A fluid bed combustor comprising a plurality of fluidized bed stages interconnected by downcomers providing controlled solids transfer from stage to stage. Each stage is formed from a number of heat transfer tubes carried by a multiapertured web which passes fluidizing air to upper stages. The combustor cross section is tapered inwardly from the middle towards the top and bottom ends. Sorbent materials, as well as non-volatile solid fuels, are added to the top stages of the combustor, and volatile solid fuels are added at an intermediate stage.

  20. Prognosis of women with stage I endometrioid endometrial cancer and synchronous stage I endometrioid ovarian cancer.

    Science.gov (United States)

    Matsuo, Koji; Machida, Hiroko; Frimer, Marina; Marcus, Jenna Z; Pejovic, Tanja; Roman, Lynda D; Wright, Jason D

    2017-12-01

    Synchronous endometrial and ovarian cancer with endometrioid histology at two cancer sites typically presents with early-stage disease and is thought to have a good prognosis. We examined the survival of women with early-stage endometrioid endometrial cancer who had synchronous early-stage endometrioid ovarian cancer. This is a retrospective case-control study examining the Surveillance, Epidemiology, and End Result Program between 1973 and 2013. Survival of women with stage I endometrioid endometrial cancer with stage I endometrioid ovarian cancer (n=839) were compared to women with stage I endometrioid endometrial cancer without synchronous ovarian cancer (n=123,692) after propensity score matching. Women with synchronous stage I endometrioid ovarian cancer were more likely to be diagnosed recently, be younger, have stage IA disease, grade 1 tumors, to have undergone lymphadenectomy, and were less likely to receive radiotherapy compared to those without synchronous ovarian cancer (all, Pendometrial cancer-specific survival (10-year rates 96.0% versus 95.3%, P=0.97) or overall survival (85.6% versus 87.2%, P=0.10). Among tumors with concordant grades at the two cancer sites, survival was similar regardless of presence of synchronous ovarian tumors (grade 1 tumors, 10-year rate for overall survival, 88.2% versus 89.1%, P=0.40; and grade 2 tumors, 84.0% versus 85.8%, P=0.78). Women with stage I endometrioid endometrial cancer with synchronous stage I endometrioid ovarian cancer have a survival outcome similar to those with stage I endometrioid endometrial cancer without synchronous ovarian cancer. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Fire on Stage

    Directory of Open Access Journals (Sweden)

    Nicholas Daly

    2017-12-01

    Full Text Available The nineteenth century theatre was fire-prone, to say the least. Across the century there were more than 1,100 major conflagrations in the world’s theatres, and countless smaller fires. In Great Britain almost every theatre seems to have burned down at some point. And yet, despite, or perhaps in part because of, this appalling record, fires were a staple feature of stage spectacle. Some plays placed them at the very centre of the entertainment, and as the century went on stage fires became more and more elaborate. Actual or simulated conflagrations were conjured up using a diverse array of technologies, some of them very simple, some depending on the most recent scientific discoveries. Here, I give a short tour of these technologies and their use in the plays of the period, and suggest some of the pleasures that they offered. While onstage flames could draw people in, offering an experience of immersive suspense, for instance, they also interrupted the dramatic flow, reminding audiences that they were seeing a performance, getting something for their money. To this extent, we are reminded that nineteenth-century drama provided something of a mixed and spectacular ‘theatre of attractions’, closer at times to the circus than to the novel.

  2. The principles of cancer staging.

    Science.gov (United States)

    Brierley, James; Gospodarowicz, Mary; O'Sullivan, Brian

    2016-01-01

    The anatomic disease extent or tumour stage of a cancer at diagnosis as a determinant of prognosis is discussed. The importance of cancer stage in individual patient prognosis and determination of treatment is reviewed as well as its value in research and cancer control activities. The conflict between the need for stability of cancer stage definitions over time and the need to evolve with advances in medicine are examined. The e cancer elearning modules on Cancer Stage are introduced.

  3. Pancreatic Cancer Stage 2B

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Pancreatic Cancer Stage 2B Add to My Pictures View /Download : ... 1500x1200 View Download Large: 3000x2400 View Download Title: Pancreatic Cancer Stage 2B Description: Stage IIB pancreatic cancer; drawing ...

  4. Pancreatic Cancer Stage 2A

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Pancreatic Cancer Stage 2A Add to My Pictures View /Download : ... 1500x1200 View Download Large: 3000x2400 View Download Title: Pancreatic Cancer Stage 2A Description: Stage IIA pancreatic cancer; drawing ...

  5. Impact of multidisciplinary teams for management of intestinal failure in children.

    Science.gov (United States)

    Belza, Christina; Wales, Paul W

    2017-06-01

    To review the recent literature related to the impact of an intestinal rehabilitation program (IRP) on the management of intestinal failure in children. As publication of a systematic review of pediatric IRPs in 2013, there have been four publications further describing the impact of IRPs in children with intestinal failure. The results continue to support an improvement in survival and enteral autonomy, and a decrease in complications related to liver dysfunction, central venous catheters, and transplantation. Pediatric IRPs offer significant advantage to outcomes of children with intestinal failure. The literature is difficult to interpret because of methodological limitations. IRP collaboration is necessary to further advance the field.

  6. Science on stage

    Science.gov (United States)

    Ciceri, Piera

    2017-04-01

    Pictures and diaries of the legendary Antarctic Expedition of sir E. Shackleton and his crew aboard the Endurance (1914/16) have become the starting point to learn about Natural Science, Earth Science and Climate Change. Students, 12 years old, were involved in hands on activities, took part to a network project, used interactive virtual labs, talked to university researchers on Skype and became the writers of a play. The theater was the place to act the story of Shackleton's expedition, to "stage" some scientific experiments and to tell to the audience about ice cores, climate change, physical and geographical characteristic of polar regions, thermal phenomena related to adaptations of polar animals, solar radiation at different latitude, day/night duration. The project was carried out from teachers of science, letters, geography and English in collaboration with the "Piccolo Teatro di Milano", the association "Scienza Under 18", researchers of the "Byrd Polar and Climate Research Center of Ohio State University" and of "M. Zucchelli Station" based in Antarctica. In our opinion drama activities improve both verbal and non-verbal communication skills and soft skills such as teamwork, responsibility and commitment. To be able to write and to act, students need a deep understanding of contents. To have an audience different from their own teachers and classmates and to interact with university researchers offer real tasks. The project aims to develop a relevant skill for the students: to become awareness citizens in a changing word.

  7. Science on stage

    CERN Multimedia

    2005-01-01

    During the opening ceremony, the audience was dazzled by a juggling show involving dramatic light effects. They also took away with them a teacher's sheet explaining some of the scientific concepts involved in juggling. Science teachers can sometimes be quite humorous when it comes to explaining serious matters, as those who took part in the 'Science on Stage' festival held at CERN from 21 to 25 November were able to see for themselves. The 500 or so participants from 27 different countries, mostly science teachers but also some university lecturers, science outreach specialists and students, had the opportunity to share their experience of the teaching of science. They also attended presentations and shows, took part in workshops and visited a fair with stands offering ideas on how to make school science lessons more appealing. The festival, organised by the EIROforum (a partnership between CERN, EFDA, ESA, ESO, EMBL, ESRF and ILL), marked the end of two years of projects for the promotion of science in vir...

  8. Status Report on Nuclear Stage Definition

    Science.gov (United States)

    Johnson, Paul G.; Harris, Ronald J.

    1970-01-01

    This status report on nuclear stage definition should convey the message that a comprehensive analysis is underway, embracing many vehicle concepts and the full range of expected RNS operations. Flexible use in the future space program is one objective; economy and ease of operations are also major goals. Not until details unfold in the several mission areas and in definitions of interrelated systems can the RNS studies be narrowed down to fewer alternatives. Consequently, the current phase of the NSSD study is emphasizing (1) in-space operations, especially as they are affected by aftercooling and the radiation environment of the stage, and (2) RNS concepts in which the unique features of nuclear propulsion are utilized or designed around. Studies to date indicate that significant benefits can be realized through use of an RNS in the missions of the 1980's. Tn the broader context of technology advancement and foundation-building for later decades, the development of a reusable nuclear stage is highly desirable. The next year's efforts will, we trust, bring us much nearer to a full understanding of the RNS and its role in the future space program.

  9. Staged membrane oxidation reactor system

    Science.gov (United States)

    Repasky, John Michael; Carolan, Michael Francis; Stein, VanEric Edward; Chen, Christopher Ming-Poh

    2013-04-16

    Ion transport membrane oxidation system comprising (a) two or more membrane oxidation stages, each stage comprising a reactant zone, an oxidant zone, one or more ion transport membranes separating the reactant zone from the oxidant zone, a reactant gas inlet region, a reactant gas outlet region, an oxidant gas inlet region, and an oxidant gas outlet region; (b) an interstage reactant gas flow path disposed between each pair of membrane oxidation stages and adapted to place the reactant gas outlet region of a first stage of the pair in flow communication with the reactant gas inlet region of a second stage of the pair; and (c) one or more reactant interstage feed gas lines, each line being in flow communication with any interstage reactant gas flow path or with the reactant zone of any membrane oxidation stage receiving interstage reactant gas.

  10. Early-stage primary school children attending a school in the Malawian School Feeding Program (SFP) have better reversal learning and lean muscle mass growth than those attending a non-SFP school.

    Science.gov (United States)

    Nkhoma, Owen W W; Duffy, Maresa E; Cory-Slechta, Deborah A; Davidson, Philip W; McSorley, Emeir M; Strain, J J; O'Brien, Gerard M

    2013-08-01

    In developing countries, schoolchildren encounter a number of challenges, including failure to complete school, poor health and nutrition, and poor academic performance. Implementation of school feeding programs (SFPs) in less developed countries is increasing and yet there is mixed evidence regarding their positive effects on nutrition, education, and cognition at the population level. This study evaluated cognitive and anthropometric outcomes in entry-level primary school children in Malawi with the aim of generating evidence for the ongoing debate about SFPs in Malawi and other developing countries. A total of 226 schoolchildren aged 6-8 y in 2 rural Malawian public primary schools were followed for one school year. Children attending one school (SFP school) received a daily ration of corn-soy blend porridge, while those attending the other (non-SFP school) did not. Baseline and post-baseline outcomes included the Cambridge Neurological Test Automated Battery cognitive tests of paired associate learning, rapid visual information processing and intra-extra dimensional shift, and anthropometric measurements of weight, height, and mid-upper arm circumference (MUAC). At follow-up, the SFP subcohort had a greater reduction than the non-SFP subcohort in the number of intra-extra predimensional shift errors made (mean 18.5 and 24.9, respectively; P-interaction = 0.02) and also showed an increase in MUAC (from 16.3 to 17.0; P-interaction school compared with children in the non-SFP school. These findings suggest that the Malawian SFP, if well managed and ration sizes are sustained, may have the potential to improve nutritional and cognitive indicators of the most disadvantaged children.

  11. Second stage gasifier in staged gasification and integrated process

    Science.gov (United States)

    Liu, Guohai; Vimalchand, Pannalal; Peng, Wan Wang

    2015-10-06

    A second stage gasification unit in a staged gasification integrated process flow scheme and operating methods are disclosed to gasify a wide range of low reactivity fuels. The inclusion of second stage gasification unit operating at high temperatures closer to ash fusion temperatures in the bed provides sufficient flexibility in unit configurations, operating conditions and methods to achieve an overall carbon conversion of over 95% for low reactivity materials such as bituminous and anthracite coals, petroleum residues and coke. The second stage gasification unit includes a stationary fluidized bed gasifier operating with a sufficiently turbulent bed of predefined inert bed material with lean char carbon content. The second stage gasifier fluidized bed is operated at relatively high temperatures up to 1400.degree. C. Steam and oxidant mixture can be injected to further increase the freeboard region operating temperature in the range of approximately from 50 to 100.degree. C. above the bed temperature.

  12. Development and Implementation of an International Counseling Outreach Effort in Bhutan: A Group Stage Conceptualization

    Science.gov (United States)

    Guth, Lorraine J.; Lorelle, Sonya; Hinkle, J. Scott; Remley, Theodore P.

    2015-01-01

    This article highlights the development and implementation of an international counseling outreach program in Bhutan using a group stage conceptualization that includes the initial, transition, working, and final stages. The initial stage included a counseling initiative started by one of the queens as well as meetings with key leaders from the…

  13. Taking centre stage...

    Science.gov (United States)

    1998-11-01

    HAMLET (Highly Automated Multimedia Light Enhanced Theatre) was the star performance at the recent finals of the `Young Engineer for Britain' competition, held at the Commonwealth Institute in London. This state-of-the-art computer-controlled theatre lighting system won the title `Young Engineers for Britain 1998' for David Kelnar, Jonathan Scott, Ramsay Waller and John Wyllie (all aged 16) from Merchiston Castle School, Edinburgh. HAMLET replaces conventional manually-operated controls with a special computer program, and should find use in the thousands of small theatres, schools and amateur drama productions that operate with limited resources and without specialist expertise. The four students received a £2500 prize between them, along with £2500 for their school, and in addition they were invited to spend a special day with the Royal Engineers. A project designed to improve car locking systems enabled Ian Robinson of Durham University to take the `Working in industry award' worth £1000. He was also given the opportunity of a day at sea with the Royal Navy. Other prizewinners with their projects included: Jun Baba of Bloxham School, Banbury (a cardboard armchair which converts into a desk and chair); Kobika Sritharan and Gemma Hancock, Bancroft's School, Essex (a rain warning system for a washing line); and Alistair Clarke, Sam James and Ruth Jenkins, Bishop of Llandaff High School, Cardiff (a mechanism to open and close the retractable roof of the Millennium Stadium in Cardiff). The two principal national sponsors of the competition, which is organized by the Engineering Council, are Lloyd's Register and GEC. Industrial companies, professional engineering institutions and educational bodies also provided national and regional prizes and support. During this year's finals, various additional activities took place, allowing the students to surf the Internet and navigate individual engineering websites on a network of computers. They also visited the

  14. Lernpunkt Deutsch--Stage 1.

    Science.gov (United States)

    Theil, Elvira

    1997-01-01

    Evaluates the first stage of "Lernpunkt Deutsch," a new three-stage German course designed for upper elementary and early secondary school. Describes the publisher's package of materials and the appropriateness of the course, utility of the different package elements, format of the materials, and assesses whether the course provides pedagogically…

  15. Surgical staging in endometrial cancer

    NARCIS (Netherlands)

    Mourits, MJ; Aalders, JG; Slager, E; Fauser, B; VanGeijn, H; Brolmann, H; Vervest, H

    2005-01-01

    Endometrial cancer is the most prevalent cancer of the female genital tract. No randomised study exists to prove that pelvic and para-aortic lymphadenectomy increases survival, either by dissecting micrometastases or by altering the adjuvant treatment in all early stage (stage I grade I and 2)

  16. Staging of renal cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Mueller-Lisse, Ullrich G.; Meindl, Thomas; Coppenrath, Eva; Degenhart, Christoph; Graser, Anno; Scherr, Michael; Reiser, Maximilian F. [Ludwig Maximilians University, Munich (Germany). Department of Clinical Radiology; Mueller-Lisse, Ulrike L. [University of Munich (Germany). Department of Urology

    2007-09-15

    As in other malignant tumors, prognosis in renal cell carcinoma (RCC) depends on tumor extent and metastasis at the time of primary diagnosis. Staging systems formalize the way in which the extent of RCC is being described and classified. Primary staging of RCC aims at evaluating surgical options. Since surgical excision, which is the mainstay of therapy in non-metastatic RCC, and, recently, minimally invasive ablation methods have evolved significantly over the last decades, staging systems continue to evolve along the way. The 40-year-old Robson classification has been replaced with the TNM classification of RCC, because the latter adapts more easily to changing patterns of diagnosis and therapy. Modern cross-sectional imaging methods, such as multidetector-row computed tomography (MDCT), and magnetic resonance imaging (MRI), perform highly in T-staging of local tumor extent and M-staging of distant metastasis. However, both MDCT and MRI perform poorly in N-staging of lymphadenopathy. At present, 18-F-desoxy-glucose positron emission tomography (FDG-PET) appears to be unreliable in the detection of RCC and its metastasis. This overview of current radiological and surgical literature attempts to describe how modern staging systems for RCC are organized, and which radiological and surgical developments currently influence the way in which primary staging and prognosis of RCC depend on one another. (orig.)

  17. Fatigue reliability based optimal design of planar compliant micropositioning stages

    Science.gov (United States)

    Wang, Qiliang; Zhang, Xianmin

    2015-10-01

    Conventional compliant micropositioning stages are usually developed based on static strength and deterministic methods, which may lead to either unsafe or excessive designs. This paper presents a fatigue reliability analysis and optimal design of a three-degree-of-freedom (3 DOF) flexure-based micropositioning stage. Kinematic, modal, static, and fatigue stress modelling of the stage were conducted using the finite element method. The maximum equivalent fatigue stress in the hinges was derived using sequential quadratic programming. The fatigue strength of the hinges was obtained by considering various influencing factors. On this basis, the fatigue reliability of the hinges was analysed using the stress-strength interference method. Fatigue-reliability-based optimal design of the stage was then conducted using the genetic algorithm and MATLAB. To make fatigue life testing easier, a 1 DOF stage was then optimized and manufactured. Experimental results demonstrate the validity of the approach.

  18. Ambulatory bruxism recording system with sleep-stage analyzing function.

    Science.gov (United States)

    Mizumori, Takahiro; Inano, Shinji; Sumiya, Masakazu; Kobayashi, Yasuyoshi; Watamoto, Takao; Yatani, Hirofumi

    2009-07-01

    The aim of this study was to develop an ambulatory bruxism recording system capable of sleep-stage analysis. A portable EMG system was used to record masseter muscle activity. An EMG sensor was attached onto the masseter muscle belly at either side. EMG data were stored on a notebook type personal computer. A sound level meter was used to assess the sound level of bruxism. Sound level (dB) readings were taken every second and recorded on the same computer. A prototype of sleep sensor, a wristwatch-style biological signal sensor-recorder device, recorded and stored pulse wave, acceleration and temperature on a memory card. All stored data were transferred to a personal computer and analyzed. The whole system was transportable within a protective case and weighed approximately 5kg. Raw EMG signals were processed to derive integrated EMG data. TOSHIBA Sleep Analysis Program classified sleep-stages as awake, shallow sleep, deep sleep and REM based on the activity of the autonomic nervous system that was estimated from the fluctuations of pulse intervals. An EMG, sound level and sleep-stage analysis program was developed to analyze all data simultaneously. Using this program, the masseter muscle activity, sound level and sleep-stage could be quantified and correlated. We developed an ambulatory bruxism recording system that analyzes sleep-stage. We expect that this system will enable us to measure sleep bruxism activity in each sleep-stage on an electromyographical and auditory basis at the subject's home.

  19. Four stages of pressure ridging

    Science.gov (United States)

    Hopkins, Mark A.

    1998-09-01

    The pressure ridging process is simulated using a two-dimensional particle model. Blocks are broken from an intact sheet of relatively thin lead ice pushed against a thick, multiyear floe at a constant speed. The blocks of ice rubble accumulate to form the ridge sail and keel. During the simulations the energy consumed in ridge growth, including dissipation, is explicitly calculated. On the basis of the results of simulations performed with the model, the ridging process can be divided into four distinct stages. The first stage begins with an intact sheet of lead ice impacting a floe and ends when the sail reaches its maximum height. In the second stage the ridge keel deepens and widens. The stage ends when the maximum keel draft is reached. In the third stage the direction of growth is leadward creating a rubble field of more or less uniform thickness. The third stage ends when the supply of thin ice is exhausted. In the fourth stage the rubble field is compressed between converging floes. The results of simulations establish the dependence of ridging energetics in the first and second stages on the thickness of the ice sheet and the amount of ice pushed into the ridge. The average profiles of the simulated ridges delineate the growth process in the first, second, and third stages. The energetics and profiles of the fourth stage were described by Hopkins et al. [1991]. Lead ice extents of up to 1300 m are pushed into ridges to determine maximum sail heights, keel drafts, and ridging forces.

  20. Korea space program

    Science.gov (United States)

    Hong, Jai-Hak

    Though Korea's space activities are just in the infant stage, we are looking forward to joining the advanced countries in the space field. We have three on-going space programs: the KOREASAT Program, a sounding rocket program, and the KITSAT Program. And, we have three more programs that we are in the process of formulating: a small remote sensing satellite program, a data receiving station construction program, and the second generation KOREASAT program. We have several organizations which are involved with space-related activities: KARI, ETRI, SERI, and KAIST. KARI was founded in 1989 in accordance with the Aerospace Industry Development & Promotion Act for the purpose of conducting research on aicraft, satellites and scientific rockets, and supporting national aerospace development projects.

  1. Cervical cancer: screening, diagnosis and staging.

    Science.gov (United States)

    Tsikouras, Panagiotis; Zervoudis, Stefanos; Manav, Bachar; Tomara, Eirini; Iatrakis, George; Romanidis, Constantinos; Bothou, Anastasia; Galazios, George

    2016-01-01

    Purpose: Despite the widespread screening programs, cervical cancer remains the third most common cancer in developing countries. Based on the implementation of cervical screening programs with the referred adoption of improved screening methods in cervical cytology with the knowledge of the important role of the human papilloma virus (HPV) it's incidence is decreased in the developed world. Even if cervical HPV infection is incredibly common, cervical cancer is relatively rare. Depending on the rarity of invasive disease and the improvement of detection of pre-cancerous lesions due to the participation in screening programs, the goal of screening is to detect the cervical lesions early in order to be treated before cancer is developed. In populations with many preventive screening programs, a decrease in cervical cancer mortality of 50-75% is mentioned over the past 50 years. The preventive examination of vagina and cervix smear, Pap test, and the HPV DNA test are remarkable diagnostic tools according to the American Cancer Association guidelines, in the investigation of asymptomatic women and in the follow up of women after the treatment of pre-invasive cervical cancer. The treatment of cervical cancer is based on the FIGO 2009 cervical cancer staging.

  2. Staged anticonvulsant screening for chronic epilepsy.

    Science.gov (United States)

    Berdichevsky, Yevgeny; Saponjian, Yero; Park, Kyung-Il; Roach, Bonnie; Pouliot, Wendy; Lu, Kimberly; Swiercz, Waldemar; Dudek, F Edward; Staley, Kevin J

    2016-12-01

    Current anticonvulsant screening programs are based on seizures evoked in normal animals. One-third of epileptic patients do not respond to the anticonvulsants discovered with these models. We evaluated a tiered program based on chronic epilepsy and spontaneous seizures, with compounds advancing from high-throughput in vitro models to low-throughput in vivo models. Epileptogenesis in organotypic hippocampal slice cultures was quantified by lactate production and lactate dehydrogenase release into culture media as rapid assays for seizure-like activity and cell death, respectively. Compounds that reduced these biochemical measures were retested with in vitro electrophysiological confirmation (i.e., second stage). The third stage involved crossover testing in the kainate model of chronic epilepsy, with blinded analysis of spontaneous seizures after continuous electrographic recordings. We screened 407 compound-concentration combinations. The cyclooxygenase inhibitor, celecoxib, had no effect on seizures evoked in normal brain tissue but demonstrated robust antiseizure activity in all tested models of chronic epilepsy. The use of organotypic hippocampal cultures, where epileptogenesis occurs on a compressed time scale, and where seizure-like activity and seizure-induced cell death can be easily quantified with biomarker assays, allowed us to circumvent the throughput limitations of in vivo chronic epilepsy models. Ability to rapidly screen compounds in a chronic model of epilepsy allowed us to find an anticonvulsant that would be missed by screening in acute models.

  3. Director, Laboratory Animal Care and Use Section

    Data.gov (United States)

    Federal Laboratory Consortium — The NIAMS Laboratory Animal Care and Use Section (LACU) provides support to all NIAMS Intramural Research Program (IRP) Branches and Laboratories using animals. The...

  4. Cognitive Development and Group Stages.

    Science.gov (United States)

    Saidla, Debie D.

    1990-01-01

    Attempts to integrate Perry's (1970) scheme of the cognitive development of college students with a model of group development adapted by Waldo (1985) based on Tuckman's (1965) formulation of developmental group stages. (Author)

  5. Stages of Huntington's Disease (HD)

    Science.gov (United States)

    ... Connect with us! What is HD? What Is Huntington’s Disease? Stages of hd The Scope of hd ... END TO HD? WHERE TO FIND HELP PUBLICATIONS Huntington’s disease (HD) is a fatal genetic disorder that ...

  6. Two-Stage Fuzzy Portfolio Selection Problem with Transaction Costs

    Directory of Open Access Journals (Sweden)

    Yanju Chen

    2015-01-01

    Full Text Available This paper studies a two-period portfolio selection problem. The problem is formulated as a two-stage fuzzy portfolio selection model with transaction costs, in which the future returns of risky security are characterized by possibility distributions. The objective of the proposed model is to achieve the maximum utility in terms of the expected value and variance of the final wealth. Given the first-stage decision vector and a realization of fuzzy return, the optimal value expression of the second-stage programming problem is derived. As a result, the proposed two-stage model is equivalent to a single-stage model, and the analytical optimal solution of the two-stage model is obtained, which helps us to discuss the properties of the optimal solution. Finally, some numerical experiments are performed to demonstrate the new modeling idea and the effectiveness. The computational results provided by the proposed model show that the more risk-averse investor will invest more wealth in the risk-free security. They also show that the optimal invested amount in risky security increases as the risk-free return decreases and the optimal utility increases as the risk-free return increases, whereas the optimal utility increases as the transaction costs decrease. In most instances the utilities provided by the proposed two-stage model are larger than those provided by the single-stage model.

  7. AAHA canine life stage guidelines.

    Science.gov (United States)

    Bartges, Joe; Boynton, Beth; Vogt, Amy Hoyumpa; Krauter, Eliza; Lambrecht, Ken; Svec, Ron; Thompson, Steve

    2012-01-01

    Guidelines are offered to guide the veterinary practitioner in designing a comprehensive, individualized wellness plan for each stage of a dog's life. Life stages are defined by both age and breed characteristics for practical purposes. Each patient visit should use an individualized approach to patient handling, preventive care, and early disease detection. Environment, behavior, nutrition, parasite control, vaccinations, dental care, zoonotic disease control, safety, and reproductive health should be addressed.

  8. Staged regenerative sorption heat pump

    Science.gov (United States)

    Jones, Jack A. (Inventor)

    1995-01-01

    A regenerative adsorbent heat pump process and system for cooling and heating a space. A sorbent is confined in a plurality of compressors of which at least four are first stage and at least four are second stage. The first stage operates over a first pressure region and the second stage over a second pressure region which is higher than the first. Sorbate from the first stage enters the second stage. The sorbate loop includes a condenser, expansion valve, evaporator and the compressors. A single sorbate loop can be employed for single-temperature-control such as air conditioning and heating. Two sorbate loops can be used for two-temperature-control as in a refrigerator and freezer. The evaporator temperatures control the freezer and refrigerator temperatures. Alternatively the refrigerator temperature can be cooled by the freezer with one sorbate loop. A heat transfer fluid is circulated in a closed loop which includes a radiator and the compressors. Low temperature heat is exhausted by the radiator. High temperature heat is added to the heat transfer fluid entering the compressors which are desorbing vapor. Heat is transferred from compressors which are sorbing vapor to the heat transfer fluid, and from the heat transfer fluid to the compressors which are desorbing vapor. Each compressor is subjected to the following phases, heating to its highest temperature, cooling down from its highest temperature, cooling to its lowest temperature, and warming up from its lowest temperature. The phases are repeated to complete a cycle and regenerate heat.

  9. A Multi-Stage Integer Programming Approach to Fantasy Team ...

    African Journals Online (AJOL)

    Team selection is a controversial topic, even more so when a team performs poorly. Many sport fans believe they can perform the selection process better than those tasked with the responsibility. With the developments of fantasy sport games, fans now have a platform to test their claims, albeit in a purely recreational ...

  10. Installation Restoration Program. Phase II. Confirmation/Quantification Stage I.

    Science.gov (United States)

    1986-02-24

    8217 ffIT.TemosrarttiM.hft... Dualty DOMKAflinsdean closed~ i p m es & Owiw’s Parma ~ M&_______________ Con"follad by 0J Vale 0 cap 0 Phag a SLATUt OF WORK L WELL TEST DATA...DAYS AWAY FROM WORK DAYS OF RESTRICTED WORK DAY ONLY CRRETVE ACTIN TAKEN BYRR TINGUN CORRETVE ACTIN THAT MEANs A N ham and by when) NAME F SUPRVISO

  11. Installation Restoration Program. Phase 2. Confirmation/Quantification. Stage 3.

    Science.gov (United States)

    1988-02-05

    Site No. 12 - ACW Disposal Site a. Conduct an intensive file search, review of building plans and aerial photography , and Interviews of personnel to...LS TDS- A .B....................... .......... .................. A1A :A - NEPAL . r’MOMOBA-S L L M MA IM D NT- P FELD BLANKS VI 54MC 4 16 C44 03

  12. Installation Restoration Program. Phase II--Confirmation/Quantification. Stage 1.

    Science.gov (United States)

    1985-03-01

    Groun&dater Samples Surface Water and Sedinent Saples Depth to water surface 5 3 Tota p4:h___________ Height of water colum Sale Depth - Sp. co. 29...Location Descriptioni: WS (I- 3 Groundwater Samples Surface Water and Sedinet Saiples Depth to wter surface Tota h Heiht of water colum Sample Depth(s...SFt,...,AGE LAGO o0o - /EST Groundwater Samples S’ fae Water and Sedimnt Samples 3/12-/;Y Depth to water surface 7"Total Depth Height of water

  13. The STAGING Text Editor/Data Base Loader Program Manual.

    Science.gov (United States)

    1980-05-01

    data base. For initial- mode runs, the system control sequence FETCH,SLOAD, CAMK . ATTACH,SINPUT,MYINPUT,ID=... SLOAD,SINPUT CATALOG,TAPEO,MYDATABASE... CAMK . ATTACH,SINPUT,MYINPUT,ID=... ATTACH,OLDDB,MYDATABASE,ID=... REQUEST,TAPEO,*PF. COPYBF,OLDDB,TAPEO. SLOAD,SINPUT. * CATALOG,TAPEO,MYNEWDATABASE...SLOADL8, DwCAM. REUINDDATA. EDITLIDI=DATA. CATALOGNEUPLSLOADPLID= CAMK . EXTENDSLOADLB. DISCARDSLOADIN. DISCARDSLOADPL. EXIT(U) RETURN

  14. Installation Restoration Program. Phase II. Confirmation/Quantification. Stage 1.

    Science.gov (United States)

    1985-07-01

    operations and north of taxiways to the main runway. The site is underlain by a system of storm drains described in subsequent sections. A 10-inch fuel... Storm drains in this area, shown on the 1959 Base topographic and utility map, suggest a hydraulic connection between this localized storm drainage...slopes to the south-southwest, with about 25 feet of relief. Major storm drains present in the area are also indicated on Figure 24. The storm

  15. A Multicut Algorithm for Two-Stage Stochastic Linear Programs.

    Science.gov (United States)

    1986-12-01

    Sciences Economiques et Sociales Facultes Universitaires N-D de la Paix B-5000 Belgium -. Technical Report 85-15 Revised December 1986 ULUCTV 7 crw ! . i...Michigan, USA 48109 Frangois V. Louveaux Faculti des Sciences Economiques et Sociales Facultis Universitaires N-D de la Paix B-5000 Belgium Abstract...Engineering The University of Michigan Ann Arbor, Michigan, USA 48109 Francois V. Louveaux Faculte des Sciences Economniques et Sociales Facultes

  16. Installation Restoration Program. Confirmation/Quantification Stage 1. Phase 2

    Science.gov (United States)

    1985-03-07

    42; ASTM , Part 31, pp 72-82, (1976), Method D-3370; and Methods for Chemical Analysis of Waters and Wastes, EPA Manual 600/4-79-020, pp xiii to xix...0.04) mg/Kg ORGANIC IODIDE ND (0.02) mg/Kg CLIENT I.D.: 84- 5773 ERG SAMPLE NO: 01/101168 MATRIX: SOIL DATE COLLECTED: 11-03-83 PARAMETER RESULTS

  17. Neoadjuvant chemotherapy in patients with stages III/IV breast ...

    African Journals Online (AJOL)

    Neoadjuvant chemotherapy in patients with stages III/IV breast cancer disease surgical experience at Muhimbili National Hospital, Dar es Salaam, Tanzania. ... Radiotherapy was given to any patient in either group where suspicion of residual tumor was present. Patients' data were entered in an SPSS window 11.5 program ...

  18. Colorectal cancer stages transcriptome analysis.

    Directory of Open Access Journals (Sweden)

    Tianyao Huo

    Full Text Available Colorectal cancer (CRC is the third most common cancer and the second leading cause of cancer-related deaths in the United States. The purpose of this study was to evaluate the gene expression differences in different stages of CRC. Gene expression data on 433 CRC patient samples were obtained from The Cancer Genome Atlas (TCGA. Gene expression differences were evaluated across CRC stages using linear regression. Genes with p≤0.001 in expression differences were evaluated further in principal component analysis and genes with p≤0.0001 were evaluated further in gene set enrichment analysis. A total of 377 patients with gene expression data in 20,532 genes were included in the final analysis. The numbers of patients in stage I through IV were 59, 147, 116 and 55, respectively. NEK4 gene, which encodes for NIMA related kinase 4, was differentially expressed across the four stages of CRC. The stage I patients had the highest expression of NEK4 genes, while the stage IV patients had the lowest expressions (p = 9*10-6. Ten other genes (RNF34, HIST3H2BB, NUDT6, LRCh4, GLB1L, HIST2H4A, TMEM79, AMIGO2, C20orf135 and SPSB3 had p value of 0.0001 in the differential expression analysis. Principal component analysis indicated that the patients from the 4 clinical stages do not appear to have distinct gene expression pattern. Network-based and pathway-based gene set enrichment analyses showed that these 11 genes map to multiple pathways such as meiotic synapsis and packaging of telomere ends, etc. Ten of these 11 genes were linked to Gene Ontology terms such as nucleosome, DNA packaging complex and protein-DNA interactions. The protein complex-based gene set analysis showed that four genes were involved in H2AX complex II. This study identified a small number of genes that might be associated with clinical stages of CRC. Our analysis was not able to find a molecular basis for the current clinical staging for CRC based on the gene expression patterns.

  19. Staging N0 oral cancer

    DEFF Research Database (Denmark)

    Thomsen, Jørn Bo; Sørensen, Jens Ahm; Grupe, Peter

    2005-01-01

    PURPOSE: To compare sentinel lymph node biopsy, magnetic resonance imaging (MRI), Doppler ultrasonography, and palpation as staging tools in patients with T1/T2 N0 cancer of the oral cavity. MATERIAL AND METHODS: Forty consecutive patients were enrolled (17 F and 23 M, aged 32-90 years), 24 T1......%, but the sensitivity of MRI 36% was low. The specificities were 100%, 85%, and 93%, respectively. By combined sentinel lymph node biopsy and ultrasonography the overall sensitivity could have been 100%. CONCLUSION: Sentinel lymph node biopsy improved staging of patients with small N0 oral cancers. Combined sentinel...

  20. Comorbidities and the Risk of Late-Stage Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Steven T. Fleming

    2006-01-01

    Full Text Available The degree to which comorbidities affect the diagnosis of prostate cancer is not clear. The purpose of this study was to determine how comorbidities affect the stage at which prostate cancer is diagnosed in elderly white and black men. We obtained data from the Surveillance, Epidemiology, and End Results program of the National Cancer Institute merged with Medicare claims data. For each patient, we estimated associations between stage of disease at diagnosis and each of the 27 comorbidities. The sample included 2,489 black and 2,587 white men with staged prostate cancer. Coronary artery disease, benign hypertension, and dyslipidemia reduced the odds of late-stage prostate cancer. A prior diagnosis of peripheral vascular disease, severe renal disease, or substance abuse increased the odds of being diagnosed with late-stage disease. The study shows some effect modification by race, particularly among white men with substance abuse, cardiac conduction disorders, and other neurologic conditions. The strongest predictors of late-stage prostate cancer diagnosis for both white and black men were age at diagnosis of at least 80 years and lack of PSA screening. Comorbidities do affect stage at diagnosis, although in different ways. Four hypotheses are discussed to explain these findings.

  1. The Stage as a Classroom.

    Science.gov (United States)

    Smoller, Fred

    1989-01-01

    Views the stage as effective in teaching critical thinking, writing, research, computer and verbal communication skills. Uses historically accurate testimony from the court martial of Lt. William Calley to demonstrate the nature of warfare and United States involvement in Vietnam. Classes dramatize the moral and ethical judgments that are made.…

  2. When science takes centre stage

    CERN Multimedia

    2005-01-01

    The teachers at 'Science on stage' are not emotionally attached to their chalk. Neither are they are weary old men who sport tweed jackets with elbow-patches and enter into conversation with their blackboards. Actually, 'Science on stage' teachers are far from the cliché of the boring physics teacher who can only inspire yawns from his pupils. Some present the basic principles of mechanics using a bicycle, others explain chemistry with examples from everyday life. The most audacious of them go so far as to explain the Doppler effect by means of a play in which Einstein dreams about jumping cows... These are but a few of the activities and plays that will be shown during the EIROforum1 Science on Stage Festival (organised by 7 European scientific organisations including CERN), to be held from 21 to 25 November at CERN, Geneva. This festival is dedicated to the teaching science in order to make it more attractive. After the first edition 'Physics on Stage' which was held in 2000 at CERN, the laboratory agai...

  3. The Staging of the Turk

    DEFF Research Database (Denmark)

    Holm, Bent

    2013-01-01

    An analytical and contextualized presentation of the figure of the Turk on the Danish stage in the 18. century with a specific focus on the interaction between the actual commercial and military circumstances on the one hand and the performative representations on the other hand. How far did...

  4. Stage-specific cancer incidence

    Science.gov (United States)

    Chefo, Solomon; Tsodikov, Alex

    2009-01-01

    SUMMARY Early detection of prostate cancer using the prostate-specific antigen test led to a sharp spike in the incidence of the disease accompanied by an equally sharp improvement in patient prognoses as evaluated at the point of advanced diagnosis. Observed outcomes represent age at diagnosis and stage, a categorical prognostic variable combining the actual stage and the grade of tumor. The picture is summarized by the stage-specific cancer incidence that represents a joint survival-multinomial response regressed on factors affecting the unobserved history of the disease before diagnosis (mixture). Fitting the complex joint mixed model to large population data is a challenge. We develop a stable and structured MLE approach to the problem allowing for the estimates to be obtained iteratively. Factorization of the likelihood achieved by our method allows us to work with only a fraction of the model dimension at a time. The approach is based on generalized self-consistency and the quasi-EM algorithm used to handle the mixed multinomial part of the response through Poisson likelihood. The model provides a causal link between the screening policy in the population and the stage-specific incidence. PMID:19452568

  5. Nuclear Cryogenic Propulsion Stage Affordable Development Strategy

    Science.gov (United States)

    Doughty, Glen E.; Gerrish, H. P.; Kenny, R. J.

    2014-01-01

    The development of nuclear power for space use in nuclear thermal propulsion (NTP) systems will involve significant expenditures of funds and require major technology development efforts. The development effort must be economically viable yet sufficient to validate the systems designed. Efforts are underway within the National Aeronautics and Space Administration's (NASA) Nuclear Cryogenic Propulsion Stage Project (NCPS) to study what a viable program would entail. The study will produce an integrated schedule, cost estimate and technology development plan. This will include the evaluation of various options for test facilities, types of testing and use of the engine, components, and technology developed. A "Human Rating" approach will also be developed and factored into the schedule, budget and technology development approach.

  6. Operation of staged membrane oxidation reactor systems

    Science.gov (United States)

    Repasky, John Michael

    2012-10-16

    A method of operating a multi-stage ion transport membrane oxidation system. The method comprises providing a multi-stage ion transport membrane oxidation system with at least a first membrane oxidation stage and a second membrane oxidation stage, operating the ion transport membrane oxidation system at operating conditions including a characteristic temperature of the first membrane oxidation stage and a characteristic temperature of the second membrane oxidation stage; and controlling the production capacity and/or the product quality by changing the characteristic temperature of the first membrane oxidation stage and/or changing the characteristic temperature of the second membrane oxidation stage.

  7. A mixed integer linear programming model applied in barge planning for Omya

    Directory of Open Access Journals (Sweden)

    David Bredström

    2015-12-01

    Full Text Available This article presents a mathematical model for barge transport planning on the river Rhine, which is part of a decision support system (DSS recently taken into use by the Swiss company Omya. The system is operated by Omya’s regional office in Cologne, Germany, responsible for distribution planning at the regional distribution center (RDC in Moerdijk, the Netherlands. The distribution planning is a vital part of supply chain management of Omya’s production of Norwegian high quality calcium carbonate slurry, supplied to European paper manufacturers. The DSS operates within a vendor managed inventory (VMI setting, where the customer inventories are monitored by Omya, who decides upon the refilling days and quantities delivered by barges. The barge planning problem falls into the category of inventory routing problems (IRP and is further characterized with multiple products, heterogeneous fleet with availability restrictions (the fleet is owned by third party, vehicle compartments, dependency of barge capacity on water-level, multiple customer visits, bounded customer inventories and rolling planning horizon. There are additional modelling details which had to be considered to make it possible to employ the model in practice at a sufficient level of detail. To the best of our knowledge, we have not been able to find similar models covering all these aspects in barge planning. This article presents the developed mixed-integer programming model and discusses practical experience with its solution. Briefly, it also puts the model into the context of the entire business case of value chain optimization in Omya.

  8. Multiple myeloma international staging system: "staging" or simply "aging" system?

    Science.gov (United States)

    Bataille, Regis; Annweiler, Cedric; Beauchet, Olivier

    2013-12-01

    Because of the wide variation in multiple myeloma (MM) survival, numerous studies have focused over the past 40 years on the biological and cytogenetic prognostic values in MM patients. Since 2005, the MM International Staging System (ISS) has recognized the combination of beta-2 microglobulin (β2M) with serum albumin (SA) concentrations as the most simple and potent combination to determine the prognosis in MM patients. Curiously, the reasons for the efficiency of the combination of β2M with SA remain not clear-cut. In 2007, Fonseca and San Miguel (Prognostic factors and staging in multiple myeloma. Hematol Oncol Clin North Am 2007; 21:1115-40) underlined that cytogenetic assessment might also be useful for evaluating MM prognosis. Furthermore, new perspectives recently appeared with the genomic approach. Here, we (1) question the specific rationale for β2M and SA as prognostic markers in MM, (2) emphasize the well-documented prognostic implications of β2M and SA as potent biomarkers of comorbidity in older adults, and (3) conclude that the current MM-ISS is rather a staging system for age-related comorbidity burden (ie, aging system) than a specific MM staging system, and should not be used alone. Thus, we suggest that: (1) cytogenetics with the superscript MM-ISS could be the standard method; (2) some factors discovered using genomics could reflect the comorbidity burden and the intrinsic malignancy of MM clone, and thus needs more investigation; and (3) while waiting for standard genomic classification. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. Survival Advantage Associated with Decrease in Stage at Detection from Stage IIIC to Stage IIIA Epithelial Ovarian Cancer

    Directory of Open Access Journals (Sweden)

    John Hoff

    2014-01-01

    Full Text Available Objective. The aim of this study was to document the survival advantage of lowering stage at detection from Stage IIIC to Stage IIIA epithelial ovarian cancer. Methods. Treatment outcomes and survival were evaluated in patients with Stage IIIA and Stage IIIC epithelial ovarian cancer treated from 2000 to 2009 at the University of Kentucky Markey Cancer Center (UKMCC and SEER institutions. Results. Cytoreduction to no visible disease (P<0.0001 and complete response to platinum-based chemotherapy (P<0.025 occurred more frequently in Stage IIIA than in Stage IIIC cases. Time to progression was shorter in patients with Stage IIIC ovarian cancer (17±1 months than in those with Stage II1A disease (36±8 months. Five-year overall survival (OS improved from 41% in Stage IIIC patients to 60% in Stage IIIA patients treated at UKMCC and from 37% to 56% in patients treated at SEER institutions for a survival advantage of 19% in both data sets. 53% of Stage IIIA and 14% of Stage IIIC patients had NED at last followup. Conclusions. Decreasing stage at detection from Stage IIIC to stage IIIA epithelial ovarian cancer is associated with a 5-year survival advantage of nearly 20% in patients treated by surgical tumor cytoreduction and platinum-based chemotherapy.

  10. Delta's inexpensive, reliable, and versatile third generation upper stage

    Science.gov (United States)

    Bonnett, E. W.; Schindler, W. R.

    1973-01-01

    The need for larger diameter fairings to encapsulate spacecraft designed to use Delta's increased lifting capabilities resulted in hammer-head design configurations that would have unaccepably degraded vehicle flight characteristics. This situation led to the development of the Straight Eight configuration. The towed mode arrangement for the second stage negated the requirement for the engine compartment structure, thus establishing the potential for an improved packaging of the hydraulic and pneumatic systems. Therefore, with cost reduction and reliability improvement objectives, a second stage propulsion system improvement program was initiated. The paper will describe these improvements and their system benefits.

  11. Designing computer programs

    CERN Document Server

    Haigh, Jim

    1994-01-01

    This is a book for students at every level who are learning to program for the first time - and for the considerable number who learned how to program but were never taught to structure their programs. The author presents a simple set of guidelines that show the programmer how to design in a manageable structure from the outset. The method is suitable for most languages, and is based on the widely used 'JSP' method, to which the student may easily progress if it is needed at a later stage.Most language specific texts contain very little if any information on design, whilst books on des

  12. Multi-Stage Plasma Thruster.

    Science.gov (United States)

    1987-06-01

    thrnste.r. is derived in Appendix C and indicates scaling of ablation-fed plasma thrusters with endo- or exo- thermic fuel slabs. IV.l. ACCELERATION OF... insulator to initiate ablation for mass-addition. PI, e15 mass (and a means of initiating current flow in the second-stage). The kinetic energy of the PPT...mechanism establishing the discharge distribution. With proper insulation , acceleration of the plasma will cease slightly beyond the end of the rails and

  13. PIRO concept: staging of sepsis.

    Science.gov (United States)

    Rathour, S; Kumar, S; Hadda, V; Bhalla, A; Sharma, N; Varma, S

    2015-01-01

    Sepsis is common presenting illness to the emergency services and one of the leading causes of hospital mortality. Researchers and clinicians have realized that the systemic inflammatory response syndrome concept for defining sepsis is less useful and lacks specificity. The predisposition, infection (or insult), response and organ dysfunction (PIRO) staging of sepsis similar to malignant diseases (TNM staging) might give better information. A prospective observational study was conducted in emergency medical services attached to medicine department of a tertiary care hospital in Northern India. Patients with age 18 years or more with proven sepsis were included in the first 24 hours of the diagnosis. Two hundred patients were recruited. Multivariate logistic regression analysis was done to assess the factors that predicted in-hospital mortality. Two hundred patients with proven sepsis, admitted to the emergency medical services were analysed. Male preponderance was noted (M: F ratio = 1.6:1). Mean age of study cohort was 50.50 ± 16.30 years. Out of 200 patients, 116 (58%) had in-hospital mortality. In multivariate logistic regression analysis, the factors independently associated with in-hospital mortality for predisposition component of PIRO staging were age >70 years, chronic obstructive pulmonary disease, chronic liver disease, cancer and presence of foley's catheter; for infection/ insult were pneumonia, urinary tract infection and meningitis/encephalitis; for response variable were tachypnea (respiratory rate >20/minute) and bandemia (band >5%). Organ dysfunction variables associated with hospital mortality were systolic blood pressure system as a predictor of in-hospital mortality was 0.94. This study finds PIRO staging as an important tool to stratify and prognosticate hospitalised patients with sepsis at a tertiary care center. The simplicity of score makes it more practical to be used in busy emergencies as it is based on four easily assessable components.

  14. Dual Stage SQL Injection Attacks

    OpenAIRE

    Eve, Martin Paul

    2009-01-01

    I came across quite an interesting SQL Injection scenario today. The software in which the vulnerability resides will remain anonymous until fixed, but an abstracted version of the scenario can safely be outlined below.\\ud \\ud The objective of the software is to restrict user accounts to certain IP addresses when accessing a bulletin board. This shows how this can be bypassed using a dual-stage SQL injection attack.

  15. Stages of motor skill learning.

    Science.gov (United States)

    Luft, Andreas R; Buitrago, Manuel M

    2005-12-01

    Successful learning of a motor skill requires repetitive training. Once the skill is mastered, it can be remembered for a long period of time. The durable memory makes motor skill learning an interesting paradigm for the study of learning and memory mechanisms. To gain better understanding, one scientific approach is to dissect the process into stages and to study these as well as their interactions. This article covers the growing evidence that motor skill learning advances through stages, in which different storage mechanisms predominate. The acquisition phase is characterized by fast (within session) and slow learning (between sessions). For a short period following the initial training sessions, the skill is labile to interference by other skills and by protein synthesis inhibition, indicating that consolidation processes occur during rest periods between training sessions. During training as well as rest periods, activation in different brain regions changes dynamically. Evidence for stages in motor skill learning is provided by experiments using behavioral, electrophysiological, functional imaging, and cellular/molecular methods.

  16. 40 CFR 264.554 - Staging piles.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Staging piles. 264.554 Section 264.554... for Cleanup § 264.554 Staging piles. This section is written in a special format to make it easier to... staging pile? A staging pile is an accumulation of solid, non-flowing remediation waste (as defined in...

  17. Introduction to stochastic dynamic programming

    CERN Document Server

    Ross, Sheldon M; Lukacs, E

    1983-01-01

    Introduction to Stochastic Dynamic Programming presents the basic theory and examines the scope of applications of stochastic dynamic programming. The book begins with a chapter on various finite-stage models, illustrating the wide range of applications of stochastic dynamic programming. Subsequent chapters study infinite-stage models: discounting future returns, minimizing nonnegative costs, maximizing nonnegative returns, and maximizing the long-run average return. Each of these chapters first considers whether an optimal policy need exist-providing counterexamples where appropriate-and the

  18. Using STEM Approach to Develop Visual Reasoning and Learning Independence for Preparatory Stage Students

    Science.gov (United States)

    Abbas, Rasha Al-Sayed Sabry

    2017-01-01

    This research aimed at investigating the effectiveness of STEM approach in developing visual reasoning and learning independence for preparatory stage students. To achieve this aim, the researcher designed a program based on STEM approach in light of the principles of nanotechnology. Twenty one preparatory stage students participated in the…

  19. 76 FR 61062 - Approval and Promulgation of Implementation Plans; Arizona; Update to Stage II Gasoline Vapor...

    Science.gov (United States)

    2011-10-03

    ...; Update to Stage II Gasoline Vapor Recovery Program; Change in the Definition of ``Gasoline'' To Exclude... emissions from the transfer of gasoline from storage tanks to motor vehicle fuel tanks at gasoline dispensing sites, i.e., stage II vapor recovery. The revisions would also amend the definition of ``gasoline...

  20. Predictors of cervical cancer being at an advanced stage at diagnosis in Sudan

    DEFF Research Database (Denmark)

    Ibrahim, Ahmed; Rasch, Vibeke; Pukkala, Eero

    2011-01-01

    Cervical cancer is the second most common cancer among women in Sudan, with more than two-thirds of all women with invasive cervical cancer being diagnosed at an advanced stage (stages III and IV). The lack of a screening program for cervical cancer in Sudan may contribute to the late presentation...... diagnosis) of cervical cancer in Sudan....

  1. Radiologic-staging: renal cell carcinoma; Radiologisches Staging des Nierenzellkarzinoms

    Energy Technology Data Exchange (ETDEWEB)

    Szolar, D.H.; Zebedin, D.; Unger, B.; Ranner, G. [Universitaetsklinik fuer Radiologie, Graz (Austria); Pummer, K. [Universitaetsklinik fuer Urologie, Graz (Austria)

    1999-07-01

    The routine staging work-up for renal cancer includes a contrast-enhanced multiphasic spiral CT and a chest radiograph. If there is doubt regarding the presence and extent of (supradiaphragmatic) IVC thrombus, MR imaging should be performed. Dynamic contrast-enhanced MR imaging should be used in place of CT in any patient with severe renal dysfunction, symptomatic polycystic kidney disease, or a history of allergy to iodinated contrast media. Cavography is no longer needed in the era of (adaptive array detector) spiral CT and MR venography. (orig.) [Deutsch] Das diagnostische Routine Work-up fuer das Nierenzellkarzinom-Staging beinhaltet ein mehrphasisches Abdomen Spiral-CT und ein Thoraxroentgen. Bei unklarem Spiral-CT Befund in der Fragestellung intravenoese Tumorausdehnung kann die kontrastmittelverstaerkte MRT eine wertvolle diagnostische Alternative darstellen. Die primaeren Indikationen zur renalen MRT stellen Patienten mit absoluter oder relativer Kontraindikation fuer nichtionische Roentgenkontrastmittel, Patienten im Stadium der kompensierten (noch nicht dialysepflichtigen) renalen Insuffizienz und Patienten mit symptomatischer polyzystischer Nierendegeneration dar. Die konventionelle Cavographie ist im Zeitalter der (Mehrzeilen-)Spiral-CT-Venographie und MR-Venographie obsolet. (orig.)

  2. Single conversion stage amplifier - SICAM

    Energy Technology Data Exchange (ETDEWEB)

    Ljusev, P.

    2005-12-15

    This Ph.D. thesis presents a thorough analysis of the so called SICAM - SIngle Converter stage AMplifier approach to building direct energy conversion audio power amplifiers. The mainstream approach for building isolated audio power amplifiers today consists of isolated DC power supply and Class D amplifier, which essentially represents a two stage solution, where each of the components can be viewed as separate and independent part. The proposed SICAM solution strives for direct energy conversion from the mains to the audio output, by dedicating the operation of the components one to another and integrating their functions, so that the final audio power amplifier represents a single-stage topology with higher efficiency, lower volume, less board space, lower component count and subsequently lower cost. The SICAM approach is both applicable to non-isolated and isolated audio power amplifiers, but the problems encountered in these two cases are different. Non-isolated SICAM solutions are intended for both AC mains-connected and battery-powered devices. In non-isolated mains-connected SICAMs the main idea is to simplify the power supply or even provide integrated power factor correction (PFC) functions, while still maintaining low component stress and good audio performance by generally decreasing the input voltage level to the Class D audio power amplifier. On the other hand, non-isolated battery-powered SICAMs have to cope with the ever changing battery voltage and provide output voltage levels which are both lower and higher than the battery voltage, while still being simple and single-stage energy conversion solutions. In isolated SICAMs the isolation transformer adjusts the voltage level on the secondary side to the desired level, so the main challenges here are decreasing the size of the magnetic core and reducing the number and size of bulky reactive components as much as possible. The main focus of this thesis is directed towards the isolated SICAMs and

  3. Stages of weight change among an occupational cohort.

    Science.gov (United States)

    Ott, Ulrike; Stanford, Joseph B; Greenwood, Jessica L J; Murtaugh, Maureen A; Gren, Lisa H; Thiese, Matthew S; Hegmann, Kurt T

    2015-03-01

    To assess the readiness to change dietary intake and body weight among production workers. We also ascertained differences between self-perceived and measured body mass index. This cross-sectional study queried physical activity, psychosocial factors, fruit and vegetable intake, and readiness to change based on the transtheoretical model. Sixty-three (28%) workers were overweight, and 114 (50%) were obese. Obese workers were in the following stages of weight change: precontemplation (4%), contemplation (45%), preparation (13%), action (21%), and (17%) maintenance. Ten percent of overweight workers erroneously reported their body mass index to be normal. About half of overweight/obese workers were in the precontemplation or contemplation stages for healthy dietary changes or weight loss. Recognizing the stages of change with regard to weight and the self-perception of weight status may help tailor workplace health promotion programs.

  4. [Initial stages of steel biocorrosion].

    Science.gov (United States)

    Zhigletsova, S K; Rodin, V B; Kobelev, V S; Aleksandrova, N V; Rasulova, G E; Kholodenko, V P

    2000-01-01

    Initial stages of corrosion of mild steel induced by Klebsiela rhinoscleromatis BO2 were studied in various media. The effect of the microorganism was detected 8-10 h after inoculation. The number of viable cells were virtually unchanged within one month in all media, but the corrosive activity of the strain decreased. The corrosive activity of microorganisms can be determined by spectrophotometry even only after incubation for 24 h. At a low level of organic substrate, even strong colonization with microorganisms does not inevitably result in a significant damage to metals.

  5. Multi-Stage Transportation Problem With Capacity Limit

    Directory of Open Access Journals (Sweden)

    I. Brezina

    2010-06-01

    Full Text Available The classical transportation problem can be applied in a more general way in practice. Related problems as Multi-commodity transportation problem, Transportation problems with different kind of vehicles, Multi-stage transportation problems, Transportation problem with capacity limit is an extension of the classical transportation problem considering the additional special condition. For solving such problems many optimization techniques (dynamic programming, linear programming, special algorithms for transportation problem etc. and heuristics approaches (e.g. evolutionary techniques were developed. This article considers Multi-stage transportation problem with capacity limit that reflects limits of transported materials (commodity quantity. Discussed issues are: theoretical base, problem formulation as way as new proposed algorithm for that problem.

  6. 2010 JPC Abstract: Ares I First Stage Propulsion System Status

    Science.gov (United States)

    Priskos, Alex S.

    2010-01-01

    In November 2005, NASA created the Constellation Program to develop an entirely new fleet of spacecraft to include the Ares I Crew Launch Vehicle and Ares V Cargo Launch vehicles. This mission architecture included the Orion capsule (which would be used to transport astronauts to low-Earth orbit and beyond), the Altair lunar lander, and an Earth departure stage. The Ares First Stage Team has made significant progress on the design of a propulsion system to meet the objectives of the Constellation Program. Work on a first stage element propulsion system capable of lofting a new fleet of spacecraft is well underway. To minimize technical risks and development costs, the Solid Rocket Boosters (SRBs) of Shuttle served as a starting point in the design of a new motor that would meet the requirements of those new vehicles. This new propulsive element will provide greater total impulse utilizing a fifth segment to loft a safer, more powerful fleet of space flight vehicles. Performance requirements, basic architecture, and obsolescence issues were all factors in determining the new first stage element design and configuration. Early efforts focused on creating designs that would be capable of supporting the requisite loads and environments. While the motor casings are Shuttle legacy, because of Ares I s unique in-line configuration, the first stage will require entirely new forward structures (forward skirt, forward skirt extension, aeroshell, and frustum) and a modified systems tunnel. The use of composites facilitated a change in the geometry, which in turn afforded the ability to focus strength where it was needed without additional mass. The Ares First Stage rocket motor casting tooling was designed and built to achieve a propellant grain geometry that produces the specific required ballistic profile. The new propellant formulation is a polybutadiene acrylonitrile (PBAN) copolymer, which has been modified to attain the desired burn rate and retain adequate tailoring

  7. Second Stage Turbine Bucket Airfoil.

    Science.gov (United States)

    Xu, Liming; Ahmadi, Majid; Humanchuk, David John; Moretto, Nicholas; Delehanty, Richard Edward

    2003-05-06

    The second-stage buckets have airfoil profiles substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in inches in Table I wherein Z is a perpendicular distance from a plane normal to a radius of the turbine centerline and containing the X and Y values with the Z value commencing at zero in the X, Y plane at the radially innermost aerodynamic section of the airfoil and X and Y are coordinate values defining the airfoil profile at each distance Z. The X, Y and Z values may be scaled as a function of the same constant or number to provide a scaled-up or scaled-down airfoil section for the bucket.

  8. Early stages of Ostwald ripening.

    Science.gov (United States)

    Shneidman, Vitaly A

    2013-07-01

    The Becker-Döring (BD) nucleation equation is known to predict a narrow double-exponential front (DEF) in the distribution of growing particles over sizes, which is due to early transient effects. When mass conservation is included, nucleation is eventually exhausted while independent growth is replaced by ripening. Despite the enormous difference in the associated time scales, and the resulting demand on numerics, within the generalized BD model the early DEF is shown to be crucial for the selection of the unique self-similar Lifshitz-Slyozov-Wagner asymptotic regime. Being preserved till the latest stages of growth, the DEF provides a universal part of the initial conditions for the ripening problem, regardless of the mass exchange mechanism between the nucleus and the matrix.

  9. Interconnected Levels of Multi-Stage Marketing

    DEFF Research Database (Denmark)

    Vedel, Mette; Geersbro, Jens; Ritter, Thomas

    2012-01-01

    different levels of multi-stage marketing and illustrates these stages with a case study. In addition, a triadic perspective is introduced as an analytical tool for multi-stage marketing research. The results from the case study indicate that multi-stage marketing exists on different levels. Thus, managers...... in a multi-stage marketing context. This understanding assists managers in assessing and balancing different aspects of multi- stage marketing. The triadic perspective also offers avenues for further research.......Multi-stage marketing gains increasing attention as knowledge of and influence on the customer's customer become more critical for the firm's success. Despite this increasing managerial relevance, systematic approaches for analyzing multi-stage marketing are still missing. This paper conceptualizes...

  10. Stage at diagnosis and ovarian cancer survival

    DEFF Research Database (Denmark)

    Maringe, Camille; Walters, Sarah; Butler, John

    2012-01-01

    We investigate what role stage at diagnosis bears in international differences in ovarian cancer survival.......We investigate what role stage at diagnosis bears in international differences in ovarian cancer survival....

  11. Instructional Program Review Guidelines, Spring 2001.

    Science.gov (United States)

    Peralta Community Coll. System, Oakland, CA. Office of Educational Services.

    This document presents guidelines for program review at Peralta Community College District's (PCCD) (California) institutions. The primary objective of the program review process is to assure that PCCD's educational programs reflect student needs and encourage student success. The review process consists of five stages: (1) a discipline self-study…

  12. Physical activity stage-matched intervention: Promoting metabolic control in type 2 diabetes.

    Science.gov (United States)

    Jalilian, Mohsen; Moeini, Babak; Hazavehei, Seyed Mohammad Mehdi; Beigi, Abbas M; Sharifirad, Gholamreza; Nodeh, Farhad Habibi

    2013-01-01

    Regular physical activity has an important role in reducing cardiovascular risk factors and improving metabolic control in patients with type 2 diabetes. This study aims to investigate the effect of physical activity stage-matched intervention on metabolic control in type 2 diabetes patients. An 8-week physical activity program conducted with 50 type 2 diabetes females who were physically inactive and in precontemplation, contemplation, and preparation stages of change. Participants were divided into intervention and control groups (each group, n = 25). Data were collected by physical activity stage of change questionnaire and metabolic factors were measured by laboratory tests before initiation program. Subsequently, stage-matched physical activity program was conducted for the interventional group. Control group received routine education from the diabetes center. After 8 weeks, physical activity questionnaire filled out by participants and metabolic factors were evaluated by a laboratory test. Findings showed patients in the intervention group and compared with control group significantly moved through stages of change after physical activity program (P-value control group and also the difference between groups was significant (P-value metabolism factors after physical activity program showed significant decrease in glycosilated hemoglobin in the intervention group than the control group (P-value metabolism factors. Designing and implementing physical activity stage-matched intervention can improve metabolic control and management of type 2 diabetes.

  13. The developmental stages of Pseudodiaptomus hessei (Copepoda ...

    African Journals Online (AJOL)

    1988-06-15

    Jun 15, 1988 ... A. Body in ventral view; B. Antennule; C. Antenna; D. Mandible; E. Maxi11ule. one basipodite segment bearing a strong masticatory process and four setae. Subsequent stages have two basi- podite segments. Two strong spines are present on the first with the addition of one seta in Stages 4 to 6. Stage 3.

  14. The developmental stages of Pseudodiaptomus hessei (Copepoda ...

    African Journals Online (AJOL)

    The developmental stages of Pseudodiaptomus hessei (Copepoda: Calanoida). H.L. Jerling, T.H. Wooldridge. Abstract. Nauplii and copepodid developmental stages of the estuarine copepod, Pseudodiaptomus hessei, are described and illustrated. Five post-embryonic naupliar and five copepodid stages (excluding adults) ...

  15. Early-stage mantle cell lymphoma

    DEFF Research Database (Denmark)

    Dabaja, B S; Zelenetz, A D; Ng, A K

    2017-01-01

    Background: Mantle cell lymphoma (MCL) rarely presents as early-stage disease, but clinical observations suggest that patients who present with early-stage disease may have better outcomes than those with advanced-stage disease. Patients and methods: In this 13-institution study, we examined...

  16. Five stages in a practical population policy.

    Science.gov (United States)

    Taylor, C E

    1968-12-01

    A systematic approach to population planning is presented. This should help to provide a basis for decision-making about emphases and priorities. The greatest force for change is the increasing world population. The sharpest controversy is between proponents of family planning, who try to make it possible for parents to have the number of children they want, and proponents of population control, who try to modify the environment so parents will want fewer children. The five developmental stages in the organization of programs are: 1) to meet the existing demand and tell women where to go for birth limitation help; 2) to provide good quality technical service, organization, and follow-up because satisfied users are the best recruiters while unsatisfied persons can produce unfavorable rumors; 3) to improve family planning motivation by caring for the health of mothers and children particularly when high infant mortality must be corrected, (the post-partum period is thought to be the best time to educate mothers); 4) to alter the family's view of its economic prospects and its understanding of financial implications of more children, particularly in underdeveloped countries; 5) to modify socio-cultural factors, such as delayed age at marriage, more education of women, and general discussions of traditional beliefs. Population policy requires long-range planning with phased action.

  17. Stages of change in physical activity behavior in children and adolescents with cerebral palsy.

    Science.gov (United States)

    Verschuren, Olaf; Wiart, Lesley; Ketelaar, Marjolijn

    2013-09-01

    To identify facilitators and barriers frequently experienced by families of children with cerebral palsy (CP) and associated with being at the pre-intention, intention and action stages for physical activity. Qualitative study involving in-depth focus group interviews with 33 ambulatory children and adolescents with CP and their parents (n = 33). These interviews were followed by questionnaires to determine stage of behavior change (i.e. pre-intention, intention and action) related to the child's participation in physical activity. Families who were classified in the intention stage of behavioral change were more likely to identify environmental barriers related to the social environment and the facility or program than parents at the pre-intention stage. Families who were classified into intention and action stages were more likely to identify facilitators related to parental factors than families at the pre-intention stage. Moreover, at the action stage facilitators were related to the facility/program. The identified facilitators and barriers, organized according to three stages of change (pre-intention, intention and action), provide important theoretical insights into how and why children and adolescents with CP and their parents might change their physical activity behavior. Understanding the barriers and facilitators of physical activity for children and adolescents with CP is essential for designing effective interventions to promote participation in this group. Using the three stages of change and the identified barriers and facilitators for participation can result in tailored advice to increase physical activity behavior.

  18. Russian Lunar Space Program

    Science.gov (United States)

    Zelenyi, Lev; Petrukovich, Anatoly; Khartov, Victor V.; Dolgopolov, Vladimir; Mitrofanov, Igor; Martunov, M.; Lukianchikov, A.; Shevchenko, Vladislav

    Russia had a great number of “firsts” in Lunar Studies (first soft landing, first pictures of the dark side of the moon, first sample return, first rover). Now after a long break the focus of Russian Space Program is again aimed to the lunar science investigations. These investigations have two aims: 1) to get answers to a principal questions of lunar formation and evolution, search for volatiles and regions with subsurface lunar permafrost, studies of lunar dust, electrostatic fields and magnetic anomalies. 2) Preparation to Lunar Exploration stage and search for most promising sites for future lunar habitable scientific stations. First stage of Russian Lunar program during this decade of 2 Lunar includes launches Landers and one Lunar orbiter, discussed in a preceding talks. Further steps during the next decade are related, first of all, with the cryogenic lunar sample return from a certain locations, hear South (or North ) poles, which according to the analysis of orbital observations are enriched by the subsurface water ice inclusions. Next steps, which are planned now are transitional to the exploration stage: delivery of a “ heavy rover“ to the specific site (thoroughly investigated during previous stages), accomplishment of technological experiments on the mitigation of lunar dust and space radiation hazards, simple initial experiments on radioastronomy and cosmic ray studies. It is a long and complicated path to go and quite naturally Russia considers that all important steps on this way will be done in international partnership.

  19. Assessing readiness to work from a stages of change perspective: implications for return to work.

    Science.gov (United States)

    Lam, Chow S; Wiley, Anne H; Siu, Andrew; Emmett, James

    2010-01-01

    The Lam Assessment on Stages of Employment Readiness (LASER) was developed to assess welfare recipients' employment readiness. The LASER consists of 14 items corresponding to Prochaska's stages of change model (Prochaska, DiClemente and Norcross, 1992). A sample of 149 welfare recipients from a work training program participated in the study. The Confirmatory Factor Analysis (CFA) supported the three factors structure corresponding to Prochaska's Pre-Contemplation, Contemplation, and Action stages. A cluster analysis classified the sample into three groups according to their LASER scores. A six months follow-up on employment outcomes showed that those who were in Pre-contemplation stage had the poorest employment outcome (25%), those who were in the Action stage had the best outcome (56%) and those in the Contemplation stage were in between (38%). Implications for work rehabilitation and treatment matching were discussed.

  20. 76 FR 627 - Medicare Program; End-Stage Renal Disease Quality Incentive Program

    Science.gov (United States)

    2011-01-05

    ... complete data source for the selected measures, but we need a sufficient time period to collect and analyze... other data sources or accurate and reliable methodologies for faster analysis of claims data become... Providers/Facilities of Their QIP Scores 3. Informing the Public Through Facility-Posted Certificates 4...

  1. 75 FR 49215 - Medicare Program; End-Stage Renal Disease Quality Incentive Program

    Science.gov (United States)

    2010-08-12

    ... management system SSA Social Security Administration the Act Social Security Act URR Urea reduction ratio I... such as demographic data, and data acquired from the Social Security Administration (SSA) and obtained...; hemodialysis adequacy; peritoneal dialysis adequacy; mineral metabolism; vascular access; patient education...

  2. 77 FR 23193 - Medicare and Medicaid Programs; Electronic Health Record Incentive Program-Stage 2; Corrections

    Science.gov (United States)

    2012-04-18

    ... typographical errors, which include the spelling out of acronyms, errors in the order of bulleted text, the... made the following errors: In Sec. 495.6(f)(1)(ii)(B) and Sec. 495.6(f)(7)(i)(E)(2), we used the word... document corrects technical errors and typographical errors in the proposed rule entitled ``Medicare and...

  3. 77 FR 53967 - Medicare and Medicaid Programs; Electronic Health Record Incentive Program-Stage 2

    Science.gov (United States)

    2012-09-04

    ... broad goal of expanding the use of EHRs through the concept of meaningful use. Section 1903(t)(6)(C) of... facilitate disease and medication management; using EHRs to engage patients and families and reporting... medication orders created by the EP or in the eligible hospital's or CAH's inpatient or emergency department...

  4. 77 FR 40951 - Medicare Program; End-Stage Renal Disease Prospective Payment System, Quality Incentive Program...

    Science.gov (United States)

    2012-07-11

    .... Hypercalcemia c. Proposed Anemia Management Reporting Measure 4. Measures Under Consideration for Future Payment... Hemodialysis HHD Home Hemodialysis ICD-9-CM International Classification of Diseases, 9th Edition, Clinical... evaluate anemia management: Hemoglobin Greater Than 12 g/dL, a clinical measure. Anemia Management, a...

  5. 78 FR 40835 - Medicare Program; End-Stage Renal Disease Prospective Payment System, Quality Incentive Program...

    Science.gov (United States)

    2013-07-08

    .... Proposed Wage Index Budget-Neutrality Adjustment 5. Application of the International Classification of.... Proposed Revised Anemia Management Reporting Measure 3. New Measures Proposed for PY 2016 and Subsequent Payment Years of the ESRD QIP a. Proposed Clinical Anemia Management Measure and Anemia Management...

  6. 78 FR 72155 - Medicare Program; End-Stage Renal Disease Prospective Payment System, Quality Incentive Program...

    Science.gov (United States)

    2013-12-02

    ... Index Budget-Neutrality Adjustment 5. Application of the International Classification of Diseases (ICD... Reporting Measure c. Revised Anemia Management Reporting Measure 3. New Measures for PY 2016 and Subsequent Payment Years of the ESRD QIP a. Anemia Management Clinical Measure Topic and Measures i. Anemia...

  7. 77 FR 67449 - Medicare Program; End-Stage Renal Disease Prospective Payment System, Quality Incentive Program...

    Science.gov (United States)

    2012-11-09

    ... Hemodialysis Adequacy b. Hypercalcemia c. Anemia Management Reporting Measure 4. Measures Under Consideration... Classification of Diseases, 9th Edition, Clinical Modifications ICH CAHPS In-Center Hemodialysis Consumer... topics as follows: To evaluate anemia management: Hemoglobin Greater Than 12 g/dL, a clinical measure...

  8. The End-Stage Renal Disease Program: Basis for the Army Organ Transplant Program

    Science.gov (United States)

    1985-07-19

    treatment facilities. Military medicine recognizes that graft survival is doubled and complicating bacteria and viral infections are halved with its use.1O...hemodialysis without sacrificing their survival would be less expensive. In contrast, the availability of suitable cadaveric organs for transplantation has...must purchase the needed kidney on the open market; in 1982 half the cadaveric kidneys transplanted were provided from civilian agencies at an

  9. Teaching object-oriented programming on top of functional programming

    DEFF Research Database (Denmark)

    Kristensen, Jens Thyge; Hansen, Michael Reichhardt; Richel, Hans

    2001-01-01

    In the Informatics Programme at the Technical University of Denmark, the authors base the first course in object-oriented programming (using the Java language) on a preceding course in functional programming (using the SML language). The students may hence exploit concepts from functional...... programming in the construction of OO programs. This is done following a method where the program design is expressed in SML and afterwards implemented in Java. The use of different languages in design and implementation is an advantage as it makes the distinction between these two stages very clear....... They give examples showing that SML designs allow them to develop and compare OO implementations with different class structures for the same programming problem. A discussion of this kind is not supported in traditional OO methodology. The program design in SML has also shown to be useful for the students...

  10. Staging of moyamoya disease by perfusion SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Kuwabara, Yasuo [Kyushu Univ., Fukuoka (Japan). Hospital; Matsushima, Toshio; Fukui, Masashi

    2001-04-01

    Staging of moyamoya disease, based on angiography and PET have already been established. The authors have established staging of moyamoya disease based on perfusion SPECT, that can be summarized as follows: Stage I, no abnormality is seen at rest or after acetazolamide loading; Stage II, no abnormality is seen at rest, however, a decreased response (blood flow increase rate: <15%) is seen to acetazolamide loading (a, a decreased response is seen only in the frontal lobe; b, a decreased response is seen in regions other than the frontal lobe; and c, a decreased response is seen throughout the cerebrum); Stage III, localized decrease in blood flow (blood flow decrease compared with peripheral tissue: {>=}15%) and marked decrease in response to acetazolamide (blood flow increase rate: <5%) are seen at rest. In Stage III, CT and MRI show no abnormal findings or only mild lesions of the white matter; and Stage IV, multiple decreases in blood flow are seen at rest, and CT and MRI reveal infarctions and severe atrophy at the same sites. The above staging does not require determination of cerebral blood flow, and thus it can be used in children, in whom cerebral blood flow determination is difficult. The authors performed 99m-Tc ECD perfusion SPECT in 25 patients with moyamoya disease for the staging, and compared staging based on angiography with staging based on perfusion SPECT. The results did not show a correlation between the 2 staging methods. A problem inherent in the staging of moyamoya disease based on perfusion SPECT is that the relationship between cerebral blood flow and cerebral radioactivity concentrations may differ depending on the drug used to determine cerebral blood flow. Thus, although the present staging system does not depend on any specific radioactive drug to determine cerebral blood flow, further investigation is necessary to identify a more appropriate drug than those in current use. (K.H.)

  11. Program specialization

    CERN Document Server

    Marlet, Renaud

    2013-01-01

    This book presents the principles and techniques of program specialization - a general method to make programs faster (and possibly smaller) when some inputs can be known in advance. As an illustration, it describes the architecture of Tempo, an offline program specializer for C that can also specialize code at runtime, and provides figures for concrete applications in various domains. Technical details address issues related to program analysis precision, value reification, incomplete program specialization, strategies to exploit specialized program, incremental specialization, and data speci

  12. Acting Antarctica: science on stage

    Science.gov (United States)

    Ciceri, Piera; Tizzoni, Paola; Pierro, Luigia

    2016-04-01

    Key-words: Polar science, Earth science, Theatre, Hands on activities The legendary Antarctic Expedition of sir E. Shackleton and his crew of 27 aboard the Endurance (1914/16) trapped in the Antarctic ice has become the starting point to learn about Polar Science and Climate Change. While the students were involved into this incredible adventure by the astonishing images of the Australian photographer Frank Hurley (who joined the crew), they discovered the world in which this story happened. Students were then involved in hands-on activities and role plays and have become the writers of the play "Uomini a scienza ai confini del mondo". They act the story of Shackelton's expedition and they tell at the same time to the audience about ice pack, ice cores and their role in understanding the past of the climate, physical and geographical characteristic of polar regions, thermal phenomena related to adaptations of polar animals, solar radiation at different latitude, day/night duration. The theater was the place to "stage" some scientific experiments and to explain the current research carried out in polar regions and their importance in climate change studies and to stress some similarities between Antarctica and space. The project was carried out from teachers of science, letters and geography and was born in collaboration with the "Piccolo Teatro di Milano" and the association "Science Under 18" with the support of a professional actor and director and was played for other schools at "EXPO 2015" in Milano (Italy). In our opinion drama activities improve reading comprehension, and both verbal and non-verbal communication skills. To be able to write and to act, students need a deep understanding of contents. Arts, including theatre, are a good key to involve emotionally students. To have an audience different from their own teachers and classmates offers a real task and the opportunity to play and let grow real skills.

  13. Growing skull fracture stages and treatment strategy.

    Science.gov (United States)

    Liu, Xue-Song; You, Chao; Lu, Ma; Liu, Jia-Gang

    2012-06-01

    A growing skull fracture (GSF) is a rare but significant late complication of skull fractures, usually occurring during infancy and early childhood. Delayed diagnosis and improper treatment could exacerbate this disease. The aim of this study was to introduce a new hypothesis about, describe the stages of, and discuss the treatment strategy for GSF. The authors performed a retrospective review of 27 patients with GSF, who were grouped according to 3 different GSF stages. Over a period of 20 years, 27 patients with GSF (16 males and 11 females) were treated in the authors' department. The mean follow-up period was 26.5 months. Six patients were in the prephase of GSF (Stage 1), 10 patients in the early phase (Stage 2), and 11 in the late phase (Stage 3). All patients underwent duraplasty. All 6 patients at Stage 1 and 5 patients at Stage 2 underwent craniotomy without cranioplasty. Five patients at Stage 2 and all of the patients at Stage 3 underwent cranioplasty with autologous bone and alloplastic materials, respectively. Among all patients, 5 underwent ventriculoperitoneal shunt placement. Symptoms in all patients at Stages 1 and 2 were alleviated or disappeared, and the cranial bones developed without deformity during follow-up. Among patients with Stage 3 GSF, no obvious improvement in neurological deficits was observed. Three patients underwent additional operations because of cranial deformation or infection. The authors identify the stages of GSF according to a new hypothesis. They conclude that accurately diagnosing and treating GSF during Stages 1 and 2 leads to a better prognosis.

  14. The study on stage financing model of IT project investment.

    Science.gov (United States)

    Chen, Si-hua; Xu, Sheng-hua; Lee, Changhoon; Xiong, Neal N; He, Wei

    2014-01-01

    Stage financing is the basic operation of venture capital investment. In investment, usually venture capitalists use different strategies to obtain the maximum returns. Due to its advantages to reduce the information asymmetry and agency cost, stage financing is widely used by venture capitalists. Although considerable attentions are devoted to stage financing, very little is known about the risk aversion strategies of IT projects. This paper mainly addresses the problem of risk aversion of venture capital investment in IT projects. Based on the analysis of characteristics of venture capital investment of IT projects, this paper introduces a real option pricing model to measure the value brought by the stage financing strategy and design a risk aversion model for IT projects. Because real option pricing method regards investment activity as contingent decision, it helps to make judgment on the management flexibility of IT projects and then make a more reasonable evaluation about the IT programs. Lastly by being applied to a real case, it further illustrates the effectiveness and feasibility of the model.

  15. Stage of urinary bladder cancer at first presentation

    Directory of Open Access Journals (Sweden)

    Al-Bazzaz Pishtewan

    2009-01-01

    Full Text Available The stage of urinary bladder cancer is an important factor in determining prognosis of the disease. This prospective study was performed to determine the stage of bladder cancer at first presentation at the Rizgary Hospital in the Erbil governorate in Iraqi Kurdistan. We evaluated 72 patients with bladder cancer. The grades and stages of bladder cancer of these patients were determined through physical examination and investigations. We found that 47.2% of patients had superficial cancer, 19.4% had tumor with invasion into the lamina propria and 30.6% of patients had tumor with invasion to muscle wall. Regional or distant metastases were found in 2.8% of patients. Well differentiated tumor was seen in 44.4% of the patients, moderately differentiated tumor was found in 38.9% and poorly differentiated tumor was found in 16.7% of the patients. Our study suggests that bladder cancer is diagnosed at a relatively early stage in the Erbil governorate. However, the situation can be further improved by adopting proper screening programs and performing appropriate investigations.

  16. Substance Abuse Treatment Stage and Personal Networks of Women in Substance Abuse Treatment

    Science.gov (United States)

    Tracy, Elizabeth M.; Kim, HyunSoo; Brown, Suzanne; Min, Meeyoung O.; Jun, Min Kyoung; McCarty, Christopher

    2012-01-01

    This study examines the relationship among 4 treatment stages (i.e., engagement, persuasion, active treatment, relapse prevention) and the composition, social support, and structural characteristics of personal networks. The study sample includes 242 women diagnosed with substance dependence who were interviewed within their first month of intensive outpatient treatment. Using EgoNet software, the women reported on their 25 alter personal networks and the characteristics of each alter. With one exception, few differences were found in the network compositions at different stages of substance abuse treatment. The exception was the network composition of women in the active treatment stage, which included more network members from treatment programs or 12-Step meetings. Although neither the type nor amount of social support differed across treatment stages, reciprocity differed between women in active treatment and those in the engagement stage. Networks of women in active treatment were less connected, as indicated by a higher number of components, whereas networks of women in the persuasion stage had a higher degree of centralization, as indicated by networks dominated by people with the most ties. Overall, we find social network structural variables to relate to the stage of treatment, whereas network composition, type of social support, and sociodemographic variables (with a few exceptions) do not relate to treatment stage. Results suggest that social context, particularly how social contacts are arranged around clients, should be incorporated into treatment programs, regardless of demographic background. PMID:22639705

  17. Pantex staging study near-term alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Madden, M.S.; Adickes, M.D.; Hostick, C.J.; Nealey, S.M.; Smith, B.W.

    1992-12-01

    As the result of bilateral treaties to reduce the number of weapons in the nuclear stockpile, the US Department of Energy must now address the requirements for additional storage of the plutonium components (pits) from the retired weapons at Pantex until the components' final disposition. Because of the critical need to take action, Pantex has initiated two related efforts: Project Stage Right and this Staging Study. While support of Project Stage Right is a key objective of this study, the scope covers a broader range of activities and aspects of the pit staging problem. This study provides estimates of worker radiation exposures under the current scenario as well as estimated radiation exposure for workers under four alternative staging scenarios. An important objective of this study also identifies and recommends for future study other activities related to staging where radiation safety and overall efficiency can be improved.

  18. Pantex staging study near-term alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Madden, M.S.; Adickes, M.D.; Hostick, C.J.; Nealey, S.M.; Smith, B.W.

    1992-12-01

    As the result of bilateral treaties to reduce the number of weapons in the nuclear stockpile, the US Department of Energy must now address the requirements for additional storage of the plutonium components (pits) from the retired weapons at Pantex until the components` final disposition. Because of the critical need to take action, Pantex has initiated two related efforts: Project Stage Right and this Staging Study. While support of Project Stage Right is a key objective of this study, the scope covers a broader range of activities and aspects of the pit staging problem. This study provides estimates of worker radiation exposures under the current scenario as well as estimated radiation exposure for workers under four alternative staging scenarios. An important objective of this study also identifies and recommends for future study other activities related to staging where radiation safety and overall efficiency can be improved.

  19. TWO STAGE FRAMEWORK FOR ALTERED FINGERPRINT MATCHING

    Directory of Open Access Journals (Sweden)

    T.R. Anoop

    2015-05-01

    Full Text Available Fingerprint alteration is the process of masking one’s identity from personal identification systems especially in boarder control security systems. Failure of matching the altered fingerprint of the criminals against the watch list of fingerprints can help them to break the security system. This fact leads to the need of a method for altered fingerprint matching. This paper presents a two stage method for altered fingerprint matching. In first stage, approximated global ridge orientation field of altered fingerprint is matched against the orientation field of its unaltered mate. If this matching is successful, fingerprints go to second stage. Second stage starts with the selection of unaltered region from the altered FP and same region from the unaltered mates. Matching in this stage is performed by extraction of ridge texture and ridge frequency from the selected region of interest. Euclidian distance is used in both stages to compute the matching score.

  20. Experimental asexual blood stage malaria immunity.

    Science.gov (United States)

    Amante, Fiona H; Engwerda, Christian R; Good, Michael F

    2011-04-01

    Immunity to asexual blood stages of malaria is complex, involving both humoral and cell-mediated immune mechanisms. The availability of murine models of malaria has greatly facilitated the analysis of immune mechanisms involved in resistance to the asexual blood stages. This unit details the materials and methods required for inducing protective immunity toward experimental blood stage malaria parasites by vaccination, repeated infection, and drug cure, as well as adoptive transfer of antigen-specific T cells.

  1. [Cryopreservation of early human embryo stages].

    Science.gov (United States)

    Vökler, T; Fliess, F R

    1988-01-01

    A short review of freezing procedures applied to early human embryos is given. It is noted that human embryos survived freezing and thawing at a developmental stage of 1. cell to blastocyst. But it seems to be necessary to use for any developmental stage of early embryo a special freezing and thawing method. Embryo survival is correlated with their morphologic features where as neither age of embryos nor developmental stage were involved in freezing and thawing ability.

  2. Designing for Different Stages in Behavior Change

    OpenAIRE

    Karapanos, Evangelos

    2016-01-01

    The behavior change process is a dynamic journey with different informational and motivational needs across its different stages; yet current technologies for behavior change are static. In our recent deployment of Habito, an activity tracking mobile app, we found individuals "readiness" to behavior change (or the stage of behavior change they were in) to be a strong predictor of adoption. Individuals in the contemplation and preparation stages had an adoption rate of 56%, whereas individuals...

  3. Experiments for Multi-Stage Processes

    DEFF Research Database (Denmark)

    Tyssedal, John; Kulahci, Murat

    2015-01-01

    Multi-stage processes are very common in both process and manufacturing industries. In this article we present a methodology for designing experiments for multi-stage processes. Typically in these situations the design is expected to involve many factors from different stages. To minimize...... the required number of experimental runs, we suggest using mirror image pairs of experiments at each stage following the first. As the design criterion, we consider their projectivity and mainly focus on projectivity 3 designs. We provide the methodology for generating these designs for processes with any...

  4. Stages of Change or Changes of Stage? Predicting Transitions in Transtheoretical Model Stages in Relation to Healthy Food Choice

    Science.gov (United States)

    Armitage, Christopher J.; Sheeran, Paschal; Conner, Mark; Arden, Madelynne A.

    2004-01-01

    Relatively little research has examined factors that account for transitions between transtheoretical model (TTM) stages of change. The present study (N=787) used sociodemographic, TTM, and theory of planned behavior (TPB) variables, as well as theory-driven interventions to predict changes in stage. Longitudinal analyses revealed that…

  5. Performance estimates for space shuttle vehicles using a hydrogen or a methane fueled turboramjet powered first stage

    Science.gov (United States)

    Knip, G., Jr.; Eisenberg, J. D.

    1972-01-01

    Two- and three-stage (second stage expendable) shuttle vehicles, both having a hydrogen-fueled, turboramjet-powered first stage, are compared with a two-stage, VTOHL, all-rocket shuttle in terms of payload fraction, inert weight, development cost, operating cost, and total cost. All of the vehicles place 22,680 kilograms of payload into a 500-kilometer orbit. The upper stage(s) uses hydrogen-oxygen rockets. The effect on payload fraction and vehicle inert weight of methane and methane-FLOX as a fuel-propellant combination for the three-stage vehicle is indicated. Compared with a rocket first stage for a two-stage shuttle, an airbreathing first stage results in a higher payload fraction and a lower operating cost, but a higher total cost. The effect on cost of program size and first-stage flyback is indicated. The addition of an expendable rocket second stage (three-stage vehicle) improves the payload fraction but is unattractive economically.

  6. One-stage and two-stage penile buccal mucosa urethroplasty

    Directory of Open Access Journals (Sweden)

    G. Barbagli

    2016-03-01

    Full Text Available The paper provides the reader with the detailed description of current techniques of one-stage and two-stage penile buccal mucosa urethroplasty. The paper provides the reader with the preoperative patient evaluation paying attention to the use of diagnostic tools. The one-stage penile urethroplasty using buccal mucosa graft with the application of glue is preliminary showed and discussed. Two-stage penile urethroplasty is then reported. A detailed description of first-stage urethroplasty according Johanson technique is reported. A second-stage urethroplasty using buccal mucosa graft and glue is presented. Finally postoperative course and follow-up are addressed.

  7. MRM Evaluation Research Program

    Science.gov (United States)

    Taylor, James C.

    1998-01-01

    This is an interim report on the current output of the MRM evaluation research program. During 1998 this research program has used new and existing data to create an important tool for the development and improvement of "maintenance resource management" (MRM). Thousands of surveys completed by participants in airline MRM training and/or behavior change programs have, for the first time, been consolidated into a panel of "MRM Attitudes and Opinion Profiles." These profiles can be used to compare the attitudes about decision making and communication in any given company at any stage in its MRM program with attitudes of a large sample of like employees during a similar period in their MRM involvement. This panel of comparison profiles for attitudes and opinions is a tool to help audit the effectiveness of a maintenance human factors program. The profile panel is the first of several tools envisioned for applying the information accumulating in MRM databases produced as one of the program's long range objectives.

  8. The European Dioxin Emission Inventory. Stage II. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Quass, U.; Fermann, M.; Broeker, G.

    2001-07-01

    For Stage II of the European Dioxin Project the following objectives were set: - Amendment of existing emission data collected for most relevant emission sources in order to reduce uncertainties of emission estimates. Collecting first emission data from countries not yet performing dioxin emission measurement programs. Extending the inventory of dioxin emissions to ambient air produced in Stage I by a complementary study on emissions to land and water. Extending the regional scope of data collection to countries in Central Europe. The report of Stage II of the European Dioxin Project is presented in 3 Volumes. Volume 1 contains an overview on the background and approach of different activities carried out and on the results obtained. These results are put into a broader view regarding the dioxin reduction measures in Europe leading to conclusions and recommendation for future work. Volume 2 of the report contains a detailed presentation of the sub-projects carried out. The chapters of Volume 2 are structured in a similar manner and start with a short summary in order to allow for a fast cross-reading. In the case of the desk-top studies an overview of the main results or statements is given. Regarding emission measurements details on the experimental set-up and the facilities being investigated are presented. Volume 3 contains a re-evaluation of the dioxin emission inventory presented for the most relevant sources types in the Stage I report. New data gathered from the projects of Stage II as well as from independent activities in the European countries are considered for a revision of the 1995 emission estimates. Additionally, based on current trends and activities the PCDD/F emissions for the years 2000 and 2005 are estimated. Finally, an attempt is made to evaluate the PCDD/F emission reduction rates which might be possible to achieve by the year 2005 compared to 1985. (orig.)

  9. The adolescent and his experience during the intermediate stage

    Directory of Open Access Journals (Sweden)

    Sophía González Zúñiga

    2015-07-01

    Full Text Available Introduction. Adolescence is considered a vulnerable stage on all people’s life. Within the health system, this population is characterized by a low coverage exclusively aimed at finding the problems, which requires more specialization. This article aims to present the situational diagnosis of a group of teenagers in the intermediate stage in order to further develop a program of Pediatric Nursing care for the adolescent in the intermediate stage, in an institution of secondary education for the years 2013-2014.Method. The implemented methodology is qualitative with a constructivist epistemological approach; triangulating the information gathered performed data analysis.Results. Among the main findings of the diagnostic phase was obtained teenagers prioritized issues such as the phenomenon of drugs and situations related to sexuality; also describe their experience along this stage of life, the changes that occurred, and interaction with peers and family, information necessary for a pediatric nurse practitioner intervene appropriately. The main findings on the diagnose phase show that adolescents prioritized issues like drugs and situations related to sexuality. They also describe their experience through this life stage, all the changes occurred and the interaction with partners and family.Conclusion. The study reveals that it is essential to establish a first contact with the adolescent to identify all their needs in an integral form, and to give them the opportunity to propose possible solutions. Being continuously in contact stimulates the development of empathy in order to obtain a greater openness from the individual to the nurse-practitioner as an accompaniment figure throughout their adolescence.

  10. Dislocation generation during early stage sintering.

    Science.gov (United States)

    Sheehan, J. E.; Lenel, F. V.; Ansell, G. S.

    1973-01-01

    Discussion of the effects of capillarity-induced stresses on dislocations during early stage sintering. A special version of Hirth's (1963) theoretical calculation procedures modified to describe dislocation nucleation on planes meeting the sintering body's neck surface obliquely is shown to predict plastic flow at stress levels know to exist between micron size metal particles in the early stages of sintering.

  11. Mediastinal staging of lung cancer: novel concepts

    NARCIS (Netherlands)

    Tournoy, Kurt G.; Keller, Steven M.; Annema, Jouke T.

    2012-01-01

    Clinical TNM staging is the standard method used to decide treatment for patients with non-small-cell lung cancer. Although integrated fluorodeoxyglucose (FDG) PET CT increases the accuracy of staging, it only guides direct tissue sampling. Histological assessment of mediastinal lymph nodes has

  12. Third Stage (S-IVB) At KSC

    Science.gov (United States)

    1960-01-01

    A NASA technician is dwarfed by the gigantic Third Stage (S-IVB) as it rests on supports in a facility at KSC. The towering 363-foot Saturn V was a multi-stage, multi-engine launch vehicle standing taller than the Statue of Liberty. Altogether, the Saturn V engines produced as much power as 85 Hoover Dams.

  13. Stage III Melanoma : Time is relative

    NARCIS (Netherlands)

    C.M.C. Oude Ophuis (Charlotte)

    2017-01-01

    textabstractIn this thesis, we show that now is the time of emerging minimally invasive and potentially even non-invasive nodal staging procedures; to reconsider which patients may actually benefit from nodal staging; to continue shared decision making for surgery as timing of surgery does not

  14. Transesophageal ultrasonography for lung cancer staging

    DEFF Research Database (Denmark)

    Konge, Lars; Annema, Jouke; Vilmann, Peter

    2013-01-01

    Accurate mediastinal nodal staging is essential for patients with resectable non-small-cell lung cancer and is achieved by combined endobronchial ultrasound and transesophageal endoscopic ultrasound (EUS). Training requirements for EUS-guided fine-needle aspiration (FNA) for lung cancer staging...

  15. The Sixth Stage of Moral Development

    Science.gov (United States)

    Morelli, E. A.

    1978-01-01

    This assessment of L. Kohlberg's theory of moral development is a dialectical critique focusing on his claim that the sixth stage of moral development is morally adequate, specifically, that it is both comprehensive and fully equilibrated. Includes a brief account of B. J. Lonergan's dialectical method and an analysis of the sixth stage of…

  16. Two-stage repair in hypospadias

    Directory of Open Access Journals (Sweden)

    K N Haxhirexha

    2008-01-01

    Full Text Available We provide the reader with a nonsystematic review concerning the use of the two-stage approach in hypospadias repairs. A one-stage approach using the tubularized incised plate urethroplasty is a well-standardized approach for the most cases of hypospadias. Nevertheless, in some primary severe cases, in most hypospadias failures and in selected patients with balanitis xerotica obliterans a two-stage approach is preferable. During the first stage the penis is straightened, if necessary and the urethral plate is substituted with a graft of either genital (prepuce or extragenital origin (oral mucosa or postauricular skin. During the second stage, performed around 6 months later, urethroplasty is accomplished by graft tubulization. Graft take is generally excellent, with only few cases requiring an additional inlay patch at second stage due to graft contracture. A staged approach allows for both excellent cosmetic results and a low morbidity including an overall 6% fistula rate and 2% stricture rate. Complications usually occur in the first year after the second stage and are higher in secondary repairs. Complications tend to decrease as experience increases and use of additional waterproofing layers contributes to reduce the fistula rate significantly. Long-term cosmetic results are excellent, but voiding and ejaculatory problems may occur in as much as 40% of cases if a long urethral tube is constructed. The procedure has a step learning curve but because of its technical simplicity does not require to be confined only to highly specialized centers.

  17. Second-Stage Music Teachers' Professional Identities

    Science.gov (United States)

    Draves, Tami J.

    2013-01-01

    The purpose of this case study research was to explore the professional identities of second-stage music teachers, or those in years 4-10 of teaching, focusing primarily on how their identities were sustained or neglected. Participants were two second stage music educators teaching in middle school (grades 6-8) music classrooms and taught…

  18. Interrelations among SMED Stages: A Causal Model

    Directory of Open Access Journals (Sweden)

    José Roberto Díaz-Reza

    2017-01-01

    Full Text Available Mexico has received a lot of foreign investment that has brought in a wide range of novel production philosophies, such as Single Minute Exchange of Dies (SMED. Despite its popularity and reported effectiveness, Mexican companies often quit SMED implementation as they consider it challenging. This usually happens when organizations are not familiarized enough with each one of the SMED stages or do not know how they are interrelated. In this article the interrelations among the different SMED implementation stages by means of a structural equations model are analyzed. Data for constructing the model were gathered from a survey administered to 250 employees from the Mexican maquiladora industry. The survey assessed the importance of 14 activities belonging to the four SMED stages. The descriptive analyses of these stages were conducted and integrated into a structural equations model as latent variables, to find their level of dependency. The model was constructed using WarpPLS 5 software, and direct, indirect, and total effects among variables are analyzed and validated. Results from the model revealed that Stage 1 of SMED implementation, known as the Identification Stage, has both direct and indirect effects on all the other SMED stages, being the most important stage.

  19. Indeterminate Pulmonary Nodules at Colorectal Cancer Staging

    DEFF Research Database (Denmark)

    Nordholm-Carstensen, Andreas; Wille-Jørgensen, Peer A; Jorgensen, Lars N

    2013-01-01

    This study aimed to estimate the prevalence of indeterminate pulmonary nodules and specific radiological and clinical characteristics that predict malignancy of these at initial staging chest computed tomography (CT) in patients with colorectal cancer. A considerable number of indeterminate...... pulmonary nodules, which cannot readily be classified as either benign or malignant, are detected at initial staging chest CT in colorectal cancer patients....

  20. Maximum likelihood estimation of signal detection model parameters for the assessment of two-stage diagnostic strategies.

    Science.gov (United States)

    Lirio, R B; Dondériz, I C; Pérez Abalo, M C

    1992-08-01

    The methodology of Receiver Operating Characteristic curves based on the signal detection model is extended to evaluate the accuracy of two-stage diagnostic strategies. A computer program is developed for the maximum likelihood estimation of parameters that characterize the sensitivity and specificity of two-stage classifiers according to this extended methodology. Its use is briefly illustrated with data collected in a two-stage screening for auditory defects.

  1. Cascode-based voltage-amplifier stage

    Directory of Open Access Journals (Sweden)

    Pospisilik Martin

    2017-01-01

    Full Text Available Voltage-amplifier stages are the basic components of commonly used high gain amplifiers the bias and other parameters of whose are set by the external negative feedback. The typical device that uses the voltage-amplifier stage is the operational amplifier. Similar constructions can also be created on the basis of discrete transistors. From the circuit designer’s point of view, the voltage-amplifier stage defines the crucial parameters of the whole unit - the amplification factor, dominant pole of its transfer function and the slew rate. In this paper the proposal on construction of the voltage-amplifier stage based on discrete transistors is described. When connected between the input differential amplifier and the output stage, it allows creating of cheap amplifier for HiFi applications with considerable performance.

  2. EFFICIENCY OF AN INDIVIDUAL REHABILITATION PROGRAM FOR PATIENTS WITH RHEUMATOID ARTHRITIS

    Directory of Open Access Journals (Sweden)

    E V Orlova

    2012-01-01

    Conclusion. The COBS platform and En-Tree M motion analysis allow one to estimate the functional status of each joint group of the lower limbs. IRP improves functional ability and motion activity (hand grip strength, power, symmetry of movements, load distribution and quality of life in RA patients immediately after its completion.

  3. Human Research Program Human Health Countermeasures Element Bone and Muscle Risk Standing Review Panel (SRP)

    Science.gov (United States)

    Glowacki, Julie; Gregor, Robert

    2009-01-01

    The Bone and Muscle Risk Standing Review Panel (SRP) met at the NASA Johnson Space Center (JSC) on October 4-6, 2009 to discuss the areas of current and future research targeted by the Human Health Countermeasures (HHC) Element of the Human Research Program (HRP). Using evidence-based knowledge as a background for identified risks to astronaut health and performance, NASA had identified gaps in knowledge to address those risks. Ongoing and proposed tasks were presented to address the gaps. The charge to the Bone and Muscle Risk SRP was to review the gaps, evaluate whether the tasks addressed these gaps and to make recommendations to NASA s HRP Science Management Office regarding the Panel's review. The Bone and Muscle Risk SRP consisted of scientists who are experts in muscle, bone, or both and could evaluate the existing evidence with sufficient knowledge of the potential effects of long duration exposure to microgravity. More important, although expertise in basic science is important, the SRP was requested to evaluate the practicality of the proposed efforts in light of the realistic demands placed on the HRP. In short, all tasks presented in the Integrated Research Plan (IRP) should address specific questions related to the challenges faced by the astronauts as a result of prolonged exposure to microgravity. All tasks proposed to fill the gaps in knowledge should provide applied, translational data necessary to answer the specific questions. Several presentations were made to the SRP during the site visit and the SRP spent sufficient time to address the panel charge, either as a group or in separate sessions for the Bone and Muscle Risk subgroups. The SRP made a final debriefing to the HRP Program Scientist, Dr. John B. Charles, on October 6, 2009. Taking the evidence and identified risks as givens, the SRP concluded that 1) integration of information should lead to a more comprehensive approach to identifying the gaps, 2) not all tasks addressed the gaps as

  4. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Hudson River: STAGING (Staging Site Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains human-use resource data for staging sites along the Hudson River. Vector points in this data set represent locations of possible staging areas...

  5. Improvements in the metabolic syndrome and stages of change for lifestyle behaviors in korean older adults.

    Science.gov (United States)

    Yoo, Seunghyun; Kim, Hyekyeong; Cho, Han-Ik

    2012-06-01

    This study aims to examine the effectiveness of a 6-month lifestyle modification program on the improvement in metabolic syndrome (MetS) status and in stages of change for lifestyle behaviors associated with MetS among Korean older adults. A lifestyle modification program was developed based on the transtheoretical model. The program consisted of health counseling, education classes, a self-management handbook, newsletters and a health diary. Older adults aged ≥60 (n = 480) with MetS were randomly assigned to the intervention group (IG) or the comparison group (CG). The IG received a comprehensive 6-month lifestyle modification intervention, while the CG received minimal information on MetS and lifestyle modification. Health examination and selfadministered survey were conducted before and after the intervention to determine the effectiveness of the program. After the intervention, the prevalence of MetS decreased to 38.1% in the IG and 52.4% in the CG (p = 0.046). The IG improved abdominal obesity (p = 0.016), blood pressure (p = 0.030), and triglyceride (p = 0.005) more than the CG did. The IG demonstrated significant improvements in the behavioral stages for portion control (p = 0.021), balanced diet (p stages at baseline to action stage at post-intervention for portion control (OR = 3.29) and adequate intake of fruits and vegetables (OR = 2.06). Lifestyle modification can improve the MetS status and behavioral stages in older adults.

  6. Tools for Reactive Distillation Column Design: Graphical and Stage-to-Stage Computation Methods

    DEFF Research Database (Denmark)

    Sanchez Daza, O.; Cisneros, Eduardo Salvador P.; Hostrup, Martin

    2001-01-01

    Based on the element mass balance concept, a graphical design method and a stage-to-stage multicomponent design method for reactive distillation columns have been developed. For distillation columns comprising reactive and non-reactive stages, a simple design strategy based on reactive and non......-reactive bubble point calculations is proposed. This strategy tracks the conversion and temperature between the feed and the end stages of the column. An illustrative example highlights the verification of the design strategy through rigorous simulation....

  7. One-stage and two-stage penile buccal mucosa urethroplasty ...

    African Journals Online (AJOL)

    The paper provides the reader with the detailed description of current techniques of one-stage and two-stage penile buccal mucosa urethroplasty. The paper provides the reader with the preoperative patient evaluation paying attention to the use of diagnostic tools. The one-stage penile urethroplasty using buccal mucosa ...

  8. A modeling comparison between a two-stage and three-stage cascaded thermoelectric generator

    Science.gov (United States)

    Kanimba, Eurydice; Pearson, Matthew; Sharp, Jeff; Stokes, David; Priya, Shashank; Tian, Zhiting

    2017-10-01

    In this work, a comparison between the performance of two- and three-stage cascaded thermoelectric generator (TEG) devices is analyzed based on a prescribed maximum hot side temperature of 973 K, an imposed maximum heat input of 505 W, and a fixed cold side temperature of 473 K. Half-Heusler is used as a thermoelectric (TE) material in the top higher temperature stage and skutterudite as a TE in the bottom lower temperature stage for the two-stage structure. Lead telluride is added in the middle stage to form the three-stage structure. Based on the prescribed constraints, the two-stage cascaded TEG is found to produce a power output of 42 W with an efficiency of 8.3%. The three-stage cascaded TEG produces a power output of 51 W with an efficiency of 10.2%. The three-stage cascaded TEG produces 21% more power than the two-stage does; however, if the system complexity, mechanical robustness, manufacturability, and/or cost of three-stage cascaded TEG outweigh the 21% percent power production increase, the two-stage TEG could be preferable.

  9. Features of the mental state of patients with myocardial infarction at a sanatorium stage of rehabilitation.

    Directory of Open Access Journals (Sweden)

    Putrov S.Yu.

    2010-11-01

    Full Text Available It is analysed the results of a research of psychological state defining of patients with myocardial infarction at a sanatorium stage of rehabilitation. It is identified a positive dynamics in the integrated application of means and methods of physical rehabilitation, and psychotherapeutic factors. The features of physical rehabilitation of patients are exposed by the heart attack of myocardium that is making program of rehabilitation on the sanatorium stage. It is certain that the program of physical rehabilitation is based on the complex of such measures as a morning hygienical gymnastics, medical gymnastics, medical dosed walking, training walking by steps.

  10. Melanoma staging and sentinel lymph node biopsy.

    Science.gov (United States)

    Forsea, Ana-Maria

    2010-01-01

    Tumor staging of melanoma is a crucial step for estimating patient prognosis, deciding on therapy approach, and efficient collection, analysis, comparison and communication of scientific data across borders and research groups. Recently, the Melanoma Staging Committee of the American Joint Committee on Cancer (AJCC) has proposed a revision of the widely used melanoma staging system, using an evidence-based approach, to reflect the improved understanding of this disease. Important adjustments were made related to the role of mitotic rate as a prognostic factor, definition of N category and classification of all microscopic nodal metastases, regardless of the extent of tumor burden, and specifically including micrometastases detected by immunohistochemistry as stage III. These revisions are to be implemented by early 2010 and are likely to be adopted and incorporated in international guidelines. Within the updated AJCC staging system, sentinel lymph node biopsy (SLNB) remains a standard-of-care diagnostic procedure, widely accepted as an important prognostic tool. According to current recommendations, SLNB is routinely offered as a staging procedure in patients with tumors more than 1 mm in thickness. Beyond its prognostic value, the therapeutic benefit of this procedure in improving overall survival yet remains to be proven. This article reviews and discusses the new aspects and challenges of the current staging recommendations for melanoma.

  11. 75th Ranger Regiment Nutrition Program

    Science.gov (United States)

    2008-07-15

    Siple Medical Training Culinary Advisor Warfighter Nutrition Conference USUHS, Bethesda, MD 15 JULY 2008 Report Documentation Page Form...Performance Nutrition ◘ Sports Medicine ◘ Mental Toughness The RAW Program Team Approach: Commander’s Program! • Ranger Leaders • Culinary ...training Overweight Fitness screening, staged training Previous Heat Injury Medical history and record screening Contributory Medical Issues Medical

  12. Developmental Stages in School Computer Use: Neither Marx Nor Piaget.

    Science.gov (United States)

    Lengel, James G.

    Karl Marx's theory of stages can be applied to computer use in the schools. The first stage, the P Stage, comprises the entry of the computer into the school. Computer use at this stage is personal and tends to center around one personality. Social studies teachers are seldom among this select few. The second stage of computer use, the D Stage, is…

  13. Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer.

    Science.gov (United States)

    Shanmugam, Chandrakumar; Hines, Robert B; Jhala, Nirag C; Katkoori, Venkat R; Zhang, Bin; Posey, James A; Bumpers, Harvey L; Grizzle, William E; Eltoum, Isam E; Siegal, Gene P; Manne, Upender

    2011-05-28

    Although evaluation of at least 12 lymph nodes (LNs) is recommended as the minimum number of nodes required for accurate staging of colon cancer patients, there is disagreement on what constitutes an adequate identification of such LNs. To evaluate the minimum number of LNs for adequate staging of Stage II and III colon cancer, 490 patients were categorized into groups based on 1-6, 7-11, 12-19, and ≥ 20 LNs collected. For patients with Stage II or III disease, examination of 12 LNs was not significantly associated with recurrence or mortality. For Stage II (HR = 0.33; 95% CI, 0.12-0.91), but not for Stage III patients (HR = 1.59; 95% CI, 0.54-4.64), examination of ≥20 LNs was associated with a reduced risk of recurrence within 2 years. However, examination of ≥20 LNs had a 55% (Stage II, HR = 0.45; 95% CI, 0.23-0.87) and a 31% (Stage III, HR = 0.69; 95% CI, 0.38-1.26) decreased risk of mortality, respectively. For each six additional LNs examined from Stage III patients, there was a 19% increased probability of finding a positive LN (parameter estimate = 0.18510, p < 0.0001). For Stage II and III colon cancers, there was improved survival and a decreased risk of recurrence with an increased number of LNs examined, regardless of the cutoff-points. Examination of ≥7 or ≥12 LNs had similar outcomes, but there were significant outcome benefits at the ≥20 cutoff-point only for Stage II patients. For Stage III patients, examination of 6 additional LNs detected one additional positive LN. Thus, the 12 LN cut-off point cannot be supported as requisite in determining adequate staging of colon cancer based on current data. However, a minimum of 6 LNs should be examined for adequate staging of Stage II and III colon cancer patients.

  14. Market-stage analysis enhances strategic planning.

    Science.gov (United States)

    McDonald, R B

    1998-07-01

    Changing market conditions are challenging healthcare organizations to determine how to allocate resources and make operational planning decisions to prepare for future changes. A vital part of meeting these challenges is understanding the impact of market stages, and using that knowledge to build effective business strategies. Financial modeling that includes market-stage information provides insight into market opportunities and presents a clearer picture of the organizational changes that will need to be implemented at each stage. Effective strategic action should take into account critical success factors in market responsiveness, organizational responsiveness, operational effectiveness, and financial strength.

  15. Ares I Stage Separation System Design Certification Testing

    Science.gov (United States)

    Mayers, Stephen L.; Beard, Bernard B.; Smith, R. Kenneth; Patterson, Alan

    2009-01-01

    NASA is committed to the development of a new crew launch vehicle, the Ares I, that can support human missions to low Earth orbit (LEO) and the moon with unprecedented safety and reliability. NASA's Constellation program comprises the Ares I and Ares V launch vehicles, the Orion crew vehicle, and the Altair lunar lander. Based on historical precedent, stage separation is one of the most significant technical and systems engineering challenges that must be addressed in order to achieve this commitment. This paper surveys historical separation system tests that have been completed in order to ensure staging of other launch vehicles. Key separation system design trades evaluated for Ares I include single vs. dual separation plane options, retro-rockets vs. pneumatic gas actuators, small solid motor quantity/placement/timing, and continuous vs. clamshell interstage configuration options. Both subscale and full-scale tests are required to address the prediction of complex dynamic loading scenarios present during staging events. Test objectives such as separation system functionality, and pyroshock and debris field measurements for the full-scale tests are described. Discussion about the test article, support infrastructure and instrumentation are provided.

  16. Stages of change in physical exercise behavior among adolescents

    Directory of Open Access Journals (Sweden)

    Alexandro Andrade

    2010-08-01

    Full Text Available The objective of the present study was to analyze the stages of behavioral change(SBC in physical exercise among adolescent from public schools in Florian��polis, SC, Brazil.The sample consisted of 400 adolescents (53.8% girls and 46.2% boys aged 14 to 18 (meanage of 16.3 years for girls and 16.4 years for boys, who were randomly selected from state highschools operating in the municipality of Florianópolis. Associations between variables wereanalyzed using the chi-square test (α=0.05. The results showed that 67.6% of the studentsperformed regularly some type of physical exercise (action and maintenance stages, whereasonly 9.8% did not exercise or did not intend to exercise (pre-contemplation stage. Boys exercisedmore than girls since they were in more advanced SBC (p<0.000. Age, school year, or periodof study was not significantly associated with EMC in the sample as a whole, but male studentswho studied in the morning were found to be more sedentary (p=0.050. The results showedthat most students of the population perform some physical exercise. However, attention shouldbe paid to a minority of students who showed a sedentary behavior, especially those who do notintend to exercise. The importance of SBC for more effective health intervention is highlightedsince, even if a program does not render an individual physically active within a short period oftime, positive long-term behavioral changes can be expected.

  17. Sandia National Laboratories corporate mentor program : program review, May 2004.

    Energy Technology Data Exchange (ETDEWEB)

    Tibbetts, Tiffany; Tarro, Talitha; Dudeck, William; Bristol, Colette; Stephens, Jim

    2005-01-01

    The Sandia National Laboratories Corporate Mentor Program provides a mechanism for the development and retention of Sandia's people and knowledge. The relationships formed among staff members at different stages in their careers offer benefits to all. These relationships can provide experienced employees with new ideas and insight and give less experienced employees knowledge of Sandia's culture, strategies, and programmatic direction. The program volunteer coordinators are dedicated to the satisfaction of the participants, who come from every area of Sandia. Since its inception in 1995, the program has sustained steady growth and excellent customer satisfaction. This report summarizes the accomplishments, activities, enhancements, and evaluation data for the Corporate Mentor Program for the 2003/2004 program year ending May 1, 2004.

  18. Stage-based interventions for smoking cessation.

    Science.gov (United States)

    Cahill, Kate; Lancaster, Tim; Green, Natasha

    2010-11-10

    The transtheoretical model is the most widely known of several stage-based theories of behaviour. It proposes that smokers move through a discrete series of motivational stages before they quit successfully. These are precontemplation (no thoughts of quitting), contemplation (thinking about quitting), preparation (planning to quit in the next 30 days), action (quitting successfully for up to six months), and maintenance (no smoking for more than six months). According to this influential model, interventions which help people to stop smoking should be tailored to their stage of readiness to quit, and are designed to move them forward through subsequent stages to eventual success. People in the preparation and action stages of quitting would require different types of support from those in precontemplation or contemplation. Our primary objective was to test the effectiveness of stage-based interventions in helping smokers to quit. We searched the Cochrane Tobacco Addiction Group's specialised register for trials, using the terms ('stage* of change', 'transtheoretical model*', 'trans-theoretical model*, 'precaution adoption model*', 'health action model', 'processes of change questionnaire*', 'readiness to change', 'tailor*') and 'smoking' in the title or abstract, or as keywords. The latest search was in August 2010. We included randomized controlled trials, which compared stage-based interventions with non-stage-based controls, with 'usual care' or with assessment only. We excluded trials which did not report a minimum follow-up period of six months from start of treatment, and those which measured stage of change but did not modify their intervention in the light of it. We extracted data in duplicate on the participants, the dose and duration of intervention, the outcome measures, the randomization procedure, concealment of allocation, and completeness of follow up.The main outcome was abstinence from smoking for at least six months. We used the most rigorous

  19. Parenting Programs

    Directory of Open Access Journals (Sweden)

    Juan Carlos Martín-Quintana

    2010-01-01

    Full Text Available This paper was aimed at emphasizing the importance of using parenting programs to promote parental competences. There is a need for this support taking into account the complexity of the parenting task in our modern societies. Following the European recommendation on positive parenting, those parenting programs are considered important measures to support parents in their educational role. Forward, several generations of parenting programs at the international context were briefly described and some examples of programs within the national context, as well. This paper provides some reflection on three models of parental education, and shows the results of an experiential parenting programs addressed to parents in psychosocial risk situation in two Spanish communities. A new program “Crecer felices en familia”, still in the implementation phase, was also described. As a conclusion, the paper emphasized the importance of evaluating programs in order to know more about their efficacy and to improve the way of implementation in real settings.

  20. Stages of Gestational Trophoblastic Tumors and Neoplasia

    Science.gov (United States)

    ... clotting problems caused by the HM. Gestational trophoblastic neoplasia (GTN) is a type of gestational trophoblastic disease ( ... the future. Stages of Gestational Trophoblastic Tumors and Neoplasia Key Points After gestational trophoblastic neoplasia has been ...

  1. Low-level waste feed staging plan

    Energy Technology Data Exchange (ETDEWEB)

    Certa, P.J.; Grams, W.H.; McConville, C.M.; L. W. Shelton, L.W.; Slaathaug, E.J., Westinghouse Hanford

    1996-08-12

    The `Preliminary Low-Level Waste Feed Staging Plan` was updated to reflect the latest requirement in the Tank Waste Remediation Privatization Request for Proposals (RFP) and amendments. The updated plan develops the sequence and transfer schedule for retrieval of DST supernate by the management and integration contractor and delivery of the staged supernate to the private low-activity waste contractors for treatment. Two DSTs are allocated as intermediate staging tanks. A transfer system conflict analysis provides part of the basis for determining transfer system upgrade requirements to support both low-activity and high-level waste feed delivery. The intermediate staging tank architecture and retrieval system equipment are provided as a planning basis until design requirements documents are prepared. The actions needed to successfully implement the plan are identified. These include resolution of safety issues and changes to the feed envelope limits, minimum order quantities, and desired batch sizes.

  2. (Kangaroo grass) at various growth stages

    African Journals Online (AJOL)

    STORAGESEVER

    2009-04-06

    Apr 6, 2009 ... Key words: Kangaroo grass, biomass, dry matter, rangeland, growth stages. INTRODUCTION ..... sativa L.) pastures. Ph.D Dissertation presented to ... Production curves for the six most important grass species in the western ...

  3. Shielded multi-stage EMI noise filter

    Science.gov (United States)

    Kisner, Roger Allen; Fugate, David Lee

    2016-11-08

    Electromagnetic interference (EMI) noise filter embodiments and methods for filtering are provided herein. EMI noise filters include multiple signal exclusion enclosures. The multiple signal exclusion enclosures contain filter circuit stages. The signal exclusion enclosures can attenuate noise generated external to the enclosures and/or isolate noise currents generated by the corresponding filter circuits within the enclosures. In certain embodiments, an output of one filter circuit stage is connected to an input of the next filter circuit stage. The multiple signal exclusion enclosures can be chambers formed using conductive partitions to divide an outer signal exclusion enclosure. EMI noise filters can also include mechanisms to maintain the components of the filter circuit stages at a consistent temperature. For example, a metal base plate can distribute heat among filter components, and an insulating material can be positioned inside signal exclusion enclosures.

  4. Konkurss "Sony Jazz Stage" otsib uusi talente

    Index Scriptorium Estoniae

    2006-01-01

    The Contemporary Music Centre'i korraldatavast konkursist "Sony Jazz Stage 2006". Võistlus toimub vokaali ja bassi (basskitarri või kontrabassi) kategoorias (The Contemporary Music Centre'i posti-või meiliaadress - vt. www.jazzkaar.ee)

  5. Staged Financing in Venture capital market.

    OpenAIRE

    Damania, Priti

    2009-01-01

    The report shows the venture capital decision making in staged financing from a real option perspective. The report also describes entrepreneur-venture capital relationship from a prisoner's dilemma approach.

  6. A two-stage fuzzy chance-constrained water management model.

    Science.gov (United States)

    Xu, Jiaxuan; Huang, Guohe; Li, Zoe; Chen, Jiapei

    2017-05-01

    In this study, an inexact two-stage fuzzy gradient chance-constrained programming (ITSFGP) method is developed and applied to the water resources management in the Heshui River Basin, Jiangxi Province, China. The optimization model is established by incorporating interval programming, two-stage stochastic programming, and fuzzy gradient chance-constrained programming within an optimization framework. The hybrid model can address uncertainties represented as fuzzy sets, probability distributions, and interval numbers. It can effectively tackle the interactions between pre-regulated economic targets and the associated environmental penalties attributed to water allocation schemes and reflect the tradeoffs between economic revenues and system-failure risk. Furthermore, uncertainties associated with the decision makers' preferences are considered in decision-making processes. The obtained results can provide decision support for the local sustainable economic development and water resources allocation strategies under multiple uncertainties.

  7. Stir Friction Welding Used in Ares I Upper Stage Fabrication

    Science.gov (United States)

    2007-01-01

    Under the goals of the Vision for Space Exploration, Ares I is a chief component of the cost-effective space transportation infrastructure being developed by NASA's Constellation Program. This transportation system will safely and reliably carry human explorers back to the moon, and then onward to Mars and other destinations in the solar system. The Ares I effort includes multiple project element teams at NASA centers and contract organizations around the nation, and is managed by the Exploration Launch Projects Office at NASA's Marshall Space Flight Center (MFSC). ATK Launch Systems near Brigham City, Utah, is the prime contractor for the first stage booster. ATK's subcontractor, United Space Alliance of Houston, is designing, developing and testing the parachutes at its facilities at NASA's Kennedy Space Center in Florida. NASA's Johnson Space Center in Houston hosts the Constellation Program and Orion Crew Capsule Project Office and provides test instrumentation and support personnel. Together, these teams are developing vehicle hardware, evolving proven technologies, and testing components and systems. Their work builds on powerful, reliable space shuttle propulsion elements and nearly a half-century of NASA space flight experience and technological advances. Ares I is an inline, two-stage rocket configuration topped by the Crew Exploration Vehicle, its service module, and a launch abort system. This HD video image depicts friction stir welding used in manufacturing aluminum panels that will fabricate the Ares I upper stage barrel. The aluminum panels are subjected to confidence panel tests during which the bent aluminum is stressed to breaking point and thoroughly examined. The panels are manufactured by AMRO Manufacturing located in El Monte, California. (Highest resolution available)

  8. [Chemoradiotherapy in early stage Hodgkin's lymphoma].

    Science.gov (United States)

    Farha, Georges; Nasr, Elie; Ghosn, Marwan; Nasr, Dolly Nehmé; Nasr, Fadi; Kattan, Joseph; Azoury, Fares; Aftimos, Philippe; Chahine, Georges

    2011-01-01

    To evaluate the response to and toxicities of chemo-radiotherapy (CT-RT) in patients with early stage Hodgkin lymphoma treated in our institution. Retrospective study of 42 patients with early stage Hodgkin lymphoma treated between 2002 and 2007. The age of patients ranges from 11 to 57 with a mean of 30.7 years; the sex-ratio is 0.8 (19 males and 23 females). There are 33 cases of nodular-sclerosing Hodgkin lymphoma, 6 of mixed cellularity, one lymphocyte-rich, one interfollicular and one granulomatous. As for the stages, 31 Hodgkin lymphomas are stage IIA, 6 stage IA, 3 bulky and 2 stage IAe. The ABVD protocol was given to 38 patients, the VBVP to 3 patients and the ABV to one patient. IFRT was used with dose ranging from 19.8 to 39.6 Gy. The acute toxicity of chemotherapy was hematologic only, grade 1 anemia accounting for 11.1% and grade 2 anemia for 14.8%, grade 1 leukopenia for 51.8%, grade 2 leukopenia for 333% and grade 3 leukopenia for 14.8%. Dysphagia, radiodermitis and radiomucositis were seen after radiotherapy, accounting for 16.5%, 4.6% and 9.1% respectively. No long-term toxicity of the combined therapy was found. During the follow-up period, one relapse occurred and no death was reported. The overall survival (OS), the disease free survival (DFS) and the toxicities of the combined therapy CT-RT of the patients with early stage Hodgkin lymphoma stage IA and IIA treated in our institution were similar to those seen in the literature.

  9. INNOVATION DIFFUSION THEORY MAIN DEVELOPMENT STAGES

    Directory of Open Access Journals (Sweden)

    S. V. Lisafiev

    2011-01-01

    Full Text Available Abstract: Main innovation diffusion development theory stages are: Rogers model of moving new products to the market including characteristics of its segments; mathematic substantiation of this model by Bass; Moor model taking into account gaps between adjacent market segments; Goldenberg model making it possible to predict sales drops at new product life cycle initial stages. It is reasonable to use this theory while moving innovative products to the market.

  10. IStage:An Interactive Stage System

    OpenAIRE

    Chacholiades, Christos; Cano, Cesar Flores; Wang, Yuying; Meldah, Eman; Omirou, Themis; Roudaut, Anne

    2016-01-01

    At present, performers need a technical team of experts to control lights, on-stage displays, and to actuate multiple devices simultaneously. All these activities have to be arranged in a complex choreography in order to allow the audience to experience the illusion of the interaction between these devices and the performer’s movements. IStage is an interactive system that allows controlling the on-stage equipment through the use of body movements and gestures. The aim is to enhance the perfo...

  11. Epacadostat and Vaccine Therapy in Treating Patients With Stage III-IV Melanoma

    Science.gov (United States)

    2018-01-09

    Mucosal Melanoma; Recurrent Melanoma; Recurrent Uveal Melanoma; Stage IIIA Skin Melanoma; Stage IIIA Uveal Melanoma; Stage IIIB Skin Melanoma; Stage IIIB Uveal Melanoma; Stage IIIC Skin Melanoma; Stage IIIC Uveal Melanoma; Stage IV Skin Melanoma; Stage IV Uveal Melanoma

  12. Two-stage designs in bioequivalence trials.

    Science.gov (United States)

    Schütz, Helmut

    2015-03-01

    The aim of this study is to assess the current status of non-fixed sample size designs in bioequivalence trials with a focus on two-stage adaptive approaches. We searched PubMed and Google Scholar from inception to October 2014. Regulatory guidelines were obtained from the public domain. Different methods were compared by Monte Carlo simulations for their impact on the patient's and producer's risks. Add-on designs, group sequential designs and adaptive two-stage sequential designs are currently accepted to demonstrate bioequivalence in various regulations. All three approaches may inflate the patient's risk if applied inconsiderately. Direct transfer of methods developed for superiority testing to bioequivalence is not warranted. Published two-stage frameworks maintain the type I error and generally the desired power. Adaptation based on the observed T/R ratio observed in the first stage should be applied with caution. Monte Carlo simulations are an efficient tool to explore the operating characteristics of methods. Validated two-stage frameworks can be applied without requiring the sponsor to perform own simulations-which could further improve power based on additional assumptions. Two-stage designs are both ethical and economical alternatives to fixed sample designs.

  13. Evaluation of stage acoustics in Seoul Arts Center Concert Hall by measuring stage support.

    Science.gov (United States)

    Jeon, Jin Yong; Barron, Michael

    2005-01-01

    Stage acoustics is an important characteristic for concert halls, both for the acoustic quality on stage and for the audience. However, relatively little research has been conducted into the question. This study was based on the investigation of an actual concert hall stage, that of the Seoul Arts Center Concert Hall in Korea. The stage acoustics was evaluated in the actual hall, and with two models: a 1:25 scale model and a computer model. The study was based on the stage support parameter ST1 proposed by Gade as a measure of support for individual performers [Acustica 65, 193-203 (1989)]. The variation of support was measured on the empty stage of the actual hall and in the two models. The effect of musicians on stage, the effect of moving the orchestra, the effect of ceiling height and of stage-wall profile were also investigated. Conclusions are drawn both relating to the Seoul Concert Hall stage and stages in general.

  14. Tools and methods for integrated resource planning. Improving energy efficiency and protecting the environment

    Energy Technology Data Exchange (ETDEWEB)

    Swisher, J.N.; Martino Jannuzzi, G. de; Redlinger, R.Y.

    1997-11-01

    This book resulted from our recognition of the need to have systematic teaching and training materials on energy efficiency, end-use analysis, demand-side management (DSM) and integrated resource planning (IRP). This book addresses energy efficiency programs and IRP, exploring their application in the electricity sector. We believe that these methods will provide powerful and practical tools for designing efficient and environmentally-sustainable energy supply and demand-side programs to minimize the economic, environmental and other social costs of electricity conversion and use. Moreover, the principles of IRP can be and already are being applied in other areas such as natural gas, water supply, and even transportation and health services. Public authorities can use IRP principles to design programs to encourage end-use efficiency and environmental protection through environmental charges and incentives, non-utility programs, and utility programs applied to the functions remaining in monopoly concessions such as the distribution wires. Competitive supply firms can use IRP principles to satisfy customer needs for efficiency and low prices, to comply with present and future environmental restrictions, and to optimize supply and demand-side investments and returns, particularly at the distribution level, where local-area IRP is now being actively practiced. Finally, in those countries where a strong planning function remains in place, IRP provides a way to integrate end-use efficiency and environmental protection into energy development. (EG) 181 refs.

  15. Material Programming

    DEFF Research Database (Denmark)

    Vallgårda, Anna; Boer, Laurens; Tsaknaki, Vasiliki

    2017-01-01

    , and color, but additionally being capable of sensing, actuating, and computing. Indeed, computers will not be things in and by themselves, but embedded into the materials that make up our surroundings. This also means that the way we interact with computers and the way we program them, will change....... Consequently we ask what the practice of programming and giving form to such materials would be like? How would we be able to familiarize ourselves with the dynamics of these materials and their different combinations of cause and effect? Which tools would we need and what would they look like? Will we program...... these computational composites through external computers and then transfer the code them, or will the programming happen closer to the materials? In this feature we outline a new research program that floats between imagined futures and the development of a material programming practice....

  16. Effective Programming

    DEFF Research Database (Denmark)

    Frost, Jacob

    To investigate the use of VTLoE as a basis for formal derivation of functional programs with effects. As a part of the process, a number of issues central to effective formal programming are considered. In particular it is considered how to develop a proof system suitable for pratical reasoning......, how to implement this system in the generic proof assistant Isabelle and finally how to apply the logic and the implementation to programming....

  17. Program Fullerene

    DEFF Research Database (Denmark)

    Wirz, Lukas; Peter, Schwerdtfeger,; Avery, James Emil

    2013-01-01

    Fullerene (Version 4.4), is a general purpose open-source program that can generate any fullerene isomer, perform topological and graph theoretical analysis, as well as calculate a number of physical and chemical properties. The program creates symmetric planar drawings of the fullerene graph......-Fowler, and Brinkmann-Fowler vertex insertions. The program is written in standard Fortran and C++, and can easily be installed on a Linux or UNIX environment....

  18. Programming Interactivity

    CERN Document Server

    Noble, Joshua

    2009-01-01

    Make cool stuff. If you're a designer or artist without a lot of programming experience, this book will teach you to work with 2D and 3D graphics, sound, physical interaction, and electronic circuitry to create all sorts of interesting and compelling experiences -- online and off. Programming Interactivity explains programming and electrical engineering basics, and introduces three freely available tools created specifically for artists and designers: Processing, a Java-based programming language and environment for building projects on the desktop, Web, or mobile phonesArduino, a system t

  19. Programming F#

    CERN Document Server

    Smith, Chris

    2009-01-01

    Why learn F#? This multi-paradigm language not only offers you an enormous productivity boost through functional programming, it also lets you develop applications using your existing object-oriented and imperative programming skills. With Programming F#, you'll quickly discover the many advantages of Microsoft's new language, which includes access to all the great tools and libraries of the .NET platform. Learn how to reap the benefits of functional programming for your next project -- whether it's quantitative computing, large-scale data exploration, or even a pursuit of your own. With th

  20. The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients

    DEFF Research Database (Denmark)

    Rudkjøbing, Vibeke Børsholt; Thomsen, Trine Rolighed; Alhede, Morten

    2012-01-01

    Patients suffering from cystic fibrosis (CF) develop chronic lung infections because of highly viscous mucus, where bacteria can form biofilms. In this study, we investigated the microorganisms present in the lungs of end-stage and non-end-stage patients using standard culturing techniques...... and molecular methods. Tissue and sputum samples (n = 34) from explanted lungs of five end-stage patients were examined along with routine expectorates (n = 15) from 13 patients with non-end-stage CF, representing earlier stages of chronic lung infections. Previously, using peptide nucleic acid (PNA......) fluorescence in situ hybridization (FISH), we have shown that Pseudomonas aeruginosa was the sole pathogen in end-stage CF lungs (Pediatr Pulmonol 2009, 44: 547). In this study, this tendency was supported by the results of real-time PCR, confirming previous results obtained by standard culturing and 16S r...

  1. Stage-by-Stage and Parallel Flow Path Compressor Modeling for a Variable Cycle Engine

    Science.gov (United States)

    Kopasakis, George; Connolly, Joseph W.; Cheng, Larry

    2015-01-01

    This paper covers the development of stage-by-stage and parallel flow path compressor modeling approaches for a Variable Cycle Engine. The stage-by-stage compressor modeling approach is an extension of a technique for lumped volume dynamics and performance characteristic modeling. It was developed to improve the accuracy of axial compressor dynamics over lumped volume dynamics modeling. The stage-by-stage compressor model presented here is formulated into a parallel flow path model that includes both axial and rotational dynamics. This is done to enable the study of compressor and propulsion system dynamic performance under flow distortion conditions. The approaches utilized here are generic and should be applicable for the modeling of any axial flow compressor design.

  2. Recognizing Developmental Stages in Southern Pine Flowers: The Key to Controlled Pollination

    Science.gov (United States)

    David L. Bramlett; Claude H. O' Gwynn

    1980-01-01

    Controlled pollinations are vital in southern pine tree improvement programs. Effective pollinations depend upon three operations. First, female flowers must be enclosed in isolation bags when they are in the proper stage of development. Then, viable pollen must be supplied to the ovules when the female flowers are most receptive. Finally, the developing cones must...

  3. Multi-Stage Optimization-Based Automatic Voltage Control Systems Considering Wind Power Forecasting Errors

    DEFF Research Database (Denmark)

    Qin, Nan; Bak, Claus Leth; Abildgaard, Hans

    2017-01-01

    cost and the generator reactive power output cost. The problem is formulated in a multi-stage optimal reactive power flow (MORPF) framework, solved by the nonlinear programming techniques via a rolling process. The voltage uncertainty caused by wind power forecasting errors is considered in the optimal...

  4. 78 FR 34303 - Approval and Promulgation of Implementation Plans; North Carolina; Removal of Stage II Gasoline...

    Science.gov (United States)

    2013-06-07

    ... II Gasoline Vapor Recovery Program AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed... for new and upgraded gasoline dispensing facilities in the State. The September 18, 2009, SIP revision... Piping for Stage II Vapor Recovery, for all new or improved gasoline tanks. In addition, rule 15A-02D...

  5. Exercise training in pediatric patients with end-stage renal disease

    NARCIS (Netherlands)

    M. van Bergen (Monique); T. Takken (Tim); R.H.H. Engelbert (Raoul); J. Groothoff (Jaap); J. Nauta (Jeroen); J. van Hoeck (Koen); P. Helders (Paul); M. Lilien (Marc)

    2009-01-01

    textabstractThe objective of this study was to determine the feasibility and efficacy of an exercise training program to improve exercise capacity and fatigue level in pediatric patients with end-stage renal disease (ESRD). Twenty children on dialysis intended to perform a 12-week graded

  6. Automated simultaneous assembly of multi-stage testing for the uniform CPA examination

    NARCIS (Netherlands)

    Breithaupt, Krista; Ariel, A.; Veldkamp, Bernard P.

    2004-01-01

    Some solutions used in the assembly of the computerized Uniform Certified Public Accountancy (CPA) licensing examination are offered as practical alternatives for operational programs producing large numbers of forms. The Uniform CPA examination will be offered as an adaptive multi-stage test (MST)

  7. Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer

    Directory of Open Access Journals (Sweden)

    Bumpers Harvey L

    2011-05-01

    Full Text Available Abstract Background Although evaluation of at least 12 lymph nodes (LNs is recommended as the minimum number of nodes required for accurate staging of colon cancer patients, there is disagreement on what constitutes an adequate identification of such LNs. Methods To evaluate the minimum number of LNs for adequate staging of Stage II and III colon cancer, 490 patients were categorized into groups based on 1-6, 7-11, 12-19, and ≥ 20 LNs collected. Results For patients with Stage II or III disease, examination of 12 LNs was not significantly associated with recurrence or mortality. For Stage II (HR = 0.33; 95% CI, 0.12-0.91, but not for Stage III patients (HR = 1.59; 95% CI, 0.54-4.64, examination of ≥20 LNs was associated with a reduced risk of recurrence within 2 years. However, examination of ≥20 LNs had a 55% (Stage II, HR = 0.45; 95% CI, 0.23-0.87 and a 31% (Stage III, HR = 0.69; 95% CI, 0.38-1.26 decreased risk of mortality, respectively. For each six additional LNs examined from Stage III patients, there was a 19% increased probability of finding a positive LN (parameter estimate = 0.18510, p Conclusions Thus, the 12 LN cut-off point cannot be supported as requisite in determining adequate staging of colon cancer based on current data. However, a minimum of 6 LNs should be examined for adequate staging of Stage II and III colon cancer patients.

  8. CHARACTERIZATION OF RIPENING STAGES OF MYRTLE FRUIT

    Directory of Open Access Journals (Sweden)

    DYALLA RIBEIRO DE ARAUJO

    2016-01-01

    Full Text Available ABSTRACT The myrtle (Eugenia gracillima Kiaersk. is a native fruit species in the Chapada of Araripe, state of Pernambuco, Brazil. The fruits are collected from the wild and are consumed fresh or processed as pulp, juice, jelly, liquor or desserts. Myrtle fruit production is of significant socioeconomic value for the region and, therefore, the description of myrtle fruit ripening stages may contribute to the development of its production chain. As a result, the objective of the present study was to evaluate the physical, quality and ripening changes of myrtle fruits at different developmental stages. The fruits were picked at five distinctive stages and evaluated for longitudinal and transverse diameters; fresh, dry and water mass; water contents; soluble solids (SS; titratable acidity (TA; pH; SS/TA ratio; carbohydrates (starch, total, reducing and nonreducing sugars; ascorbic acid; total pectin, soluble pectins and percentage of pectin solubilization; polymeric, oligomeric and dimeric phenolics; total anthocyanins, carotenoids and chlorophyll; and yellow flavonoids. Along fruit ripening processes increases in SS, anthocyanins and carotenoids, in the SS/TA ratio and of percentages of pectin solubilization were determined. On the other hand, decreases in TA and total chlorophyll were observed. The ripening stage at which peel color is completely dark red (ripening stage 4 is most appropriate to harvest myrtle fruits for human consumption.

  9. Large-Scale Automated Sleep Staging.

    Science.gov (United States)

    Sun, Haoqi; Jia, Jian; Goparaju, Balaji; Huang, Guang-Bin; Sourina, Olga; Bianchi, Matt Travis; Westover, M Brandon

    2017-10-01

    Automated sleep staging has been previously limited by a combination of clinical and physiological heterogeneity. Both factors are in principle addressable with large data sets that enable robust calibration. However, the impact of sample size remains uncertain. The objectives are to investigate the extent to which machine learning methods can approximate the performance of human scorers when supplied with sufficient training cases and to investigate how staging performance depends on the number of training patients, contextual information, model complexity, and imbalance between sleep stage proportions. A total of 102 features were extracted from six electroencephalography (EEG) channels in routine polysomnography. Two thousand nights were partitioned into equal (n = 1000) training and testing sets for validation. We used epoch-by-epoch Cohen's kappa statistics to measure the agreement between classifier output and human scorer according to American Academy of Sleep Medicine scoring criteria. Epoch-by-epoch Cohen's kappa improved with increasing training EEG recordings until saturation occurred (n = ~300). The kappa value was further improved by accounting for contextual (temporal) information, increasing model complexity, and adjusting the model training procedure to account for the imbalance of stage proportions. The final kappa on the testing set was 0.68. Testing on more EEG recordings leads to kappa estimates with lower variance. Training with a large data set enables automated sleep staging that compares favorably with human scorers. Because testing was performed on a large and heterogeneous data set, the performance estimate has low variance and is likely to generalize broadly.

  10. Diagnosis, staging and treatment of hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    A.V.C. França

    2004-11-01

    Full Text Available Hepatocellular carcinomas are aggressive tumors with a high dissemination power. An early diagnosis of these tumors is of great importance in order to offer the possibility of curative treatment. For an early diagnosis, abdominal ultrasound and serum alpha-fetoprotein determinations at 6-month intervals are suggested for all patients with cirrhosis of the liver, since this disease is considered to be the main risk factor for the development of the neoplasia. Helicoidal computed tomography, magnetic resonance and/or hepatic arteriography are suggested for diagnostic confirmation and tumor staging. The need to obtain a fragment of the focal lesion for cytology and/or histology for a diagnosis of hepatocellular carcinoma depends on the inability of imaging methods to diagnose the lesion. Several classifications are currently available for tumor staging in order to determine patient prognosis. All take into consideration not only the stage of the tumor but also the degree of hepatocellular dysfunction, which is known to be the main factor related to patient survival. Classifications, however, fail to correlate treatment with prognosis and cannot suggest the ideal treatment for each tumor stage. The Barcelona Classification (BCLC attempts to correlate tumor stage with treatment but requires prospective studies for validation. For single tumors smaller than 5 cm or up to three nodules smaller than 3 cm, surgical resection, liver transplantation and percutaneous treatment may offer good anti-tumoral results, as well as improved patient survival. Embolization or chemoembolization are therapeutic alternatives for patients who do not benefit from curative therapies.

  11. Assessing Behavioral Stages From Social Media Data

    Science.gov (United States)

    Liu, Jason; Weitzman, Elissa R; Chunara, Rumi

    2017-01-01

    Important work rooted in psychological theory posits that health behavior change occurs through a series of discrete stages. Our work builds on the field of social computing by identifying how social media data can be used to resolve behavior stages at high resolution (e.g. hourly/daily) for key population subgroups and times. In essence this approach opens new opportunities to advance psychological theories and better understand how our health is shaped based on the real, dynamic, and rapid actions we make every day. To do so, we bring together domain knowledge and machine learning methods to form a hierarchical classification of Twitter data that resolves different stages of behavior. We identify and examine temporal patterns of the identified stages, with alcohol as a use case (planning or looking to drink, currently drinking, and reflecting on drinking). Known seasonal trends are compared with findings from our methods. We discuss the potential health policy implications of detecting high frequency behavior stages. PMID:29034371

  12. Energy Innovation Acceleration Program

    Energy Technology Data Exchange (ETDEWEB)

    Wolfson, Johanna [Fraunhofer USA Inc., Center for Sustainable Energy Systems, Boston, MA (United States)

    2015-06-15

    The Energy Innovation Acceleration Program (IAP) – also called U-Launch – has had a significant impact on early stage clean energy companies in the Northeast and on the clean energy economy in the Northeast, not only during program execution (2010-2014), but continuing into the future. Key results include: Leverage ratio of 105:1; $105M in follow-on funding (upon $1M investment by EERE); At least 19 commercial products launched; At least 17 new industry partnerships formed; At least $6.5M in revenue generated; >140 jobs created; 60% of assisted companies received follow-on funding within 1 year of program completion; In addition to the direct measurable program results summarized above, two primary lessons emerged from our work executing Energy IAP:; Validation and demonstration awards have an outsized, ‘tipping-point’ effect for startups looking to secure investments and strategic partnerships. An ecosystem approach is valuable, but an approach that evaluates the needs of individual companies and then draws from diverse ecosystem resources to fill them, is most valuable of all.

  13. Method of selecting an optimum solution for 2-stage separation of gases using a computer

    Energy Technology Data Exchange (ETDEWEB)

    Ramazanova, E.E.; Ramazanova, Z.E.; Dilbazi, Z.G.

    1971-01-01

    One of the reasons for a drop in transmission capacity of gas pipelines is deposition of condensate in the line. This problem was considered from 2 standpoints: (1) to determine efficiency of 2-stage gas separation for a series of gas-condensate fields in Azerbaidzhan; and (2) to develop a method of choosing the optimum operating regime for 2-stage separation, according to criteria of maximum condensate recovery. The analytical solution of this problem used an equation of concentration and phase equilibria. It was found that for a daily gas production of one million cubic meters at one field, second stage gas separation can produce an additional 12; 10 and 5 tons of condensate at separation temperatures of 10/sup 0/, 15/sup 0/ and 25/sup 0/C respectively, and separation pressure of 35 atm. Calculations for other fields also showed the beneficial effect of 2-stage separation. A schematic block diagram of the program used with the computer is shown.

  14. Computer Programs.

    Science.gov (United States)

    Anderson, Tiffoni

    This module provides information on development and use of a Material Safety Data Sheet (MSDS) software program that seeks to link literacy skills education, safety training, and human-centered design. Section 1 discusses the development of the software program that helps workers understand the MSDSs that accompany the chemicals with which they…

  15. Influence of growth stage at harvest on fermentative characteristics ...

    African Journals Online (AJOL)

    In both directly cut as well as prior wilted silage, a higher lactic acid concentration was recorded on day 7 in the boot stage silage compared to the full bloom stage silage, but on day 21 the boot stage had a lower lactic acid concentration than that of the full bloom stage silage. Growth stage had no effect on the acetic acid ...

  16. Mars Science Laboratory Rover and Descent Stage

    Science.gov (United States)

    2009-01-01

    In this February 17, 2009, image, NASA's Mars Science Laboratory rover is attached to the spacecraft's descent stage. The image was taken inside the Spacecraft Assembly Facility at NASA's Jet Propulsion Laboratory, Pasadena, Calif. This is the way the spacecraft will look after it comes out of its protective aeroshell and is descending to the Martian surface in 2012. Here, the descent stage sits on top of the rover, with its eight main engines straddling the rover structure. The rover is the big white box below the descent stage. At this point, the rover lacks its appendages (robotic arm, mast and most wheels), as these elements are still being assembled and were not needed for space-simulation testing of the spacecraft in late 2008.

  17. Stage- vs. Channel-strip Metaphor

    DEFF Research Database (Denmark)

    Gelineck, Steven; Korsgaard, Dannie Michael; Büchert, Morten

    2015-01-01

    This study compares the stage metaphor and the channel strip metaphor in terms of performance. Traditionally, music mixing consoles employ a channels strip control metaphor for adjusting parameters such as volume and panning of each track. An alternative control metaphor, the so-called stage...... metaphor lets the user adjust volume and panning by positioning tracks relative to a virtual listening position. In this study test participants are given the task to adjust volume and panning of one channel (in mixes consisting of three channels) in order to replicate a series of simple pre-rendered mixes....... They do this using (1) a small physical mixing controller and (2) using an iPad app, which implements a simple stage metaphor interface. We measure how accurately they are able to replicate mixes in terms of volume and panning and how fast they are at doing so. Results reveal that performance...

  18. Early stage malignant phyllodes tumor case report.

    Science.gov (United States)

    Wolbert, Thao; Leigh, Emilia C N; Barry, Rahman; Traylor, Jack R; Legenza, Mary

    2018-01-01

    Malignant phyllodes tumor of the breast is an extremely rare entity usually presenting with similar clinical features with those of benign fibroadenoma. Due to its scarcity and clinical presentation, it is quite difficult for clinicians to suspect and diagnose the disease at its early stage. There is currently no consensus regarding adjunctive radiotherapy, hormonal therapy and systemic chemotherapy recommended for malignant phyllodes tumors. This report presents a case of early-stage malignant phyllodes tumor treated by lumpectomy only without adjunctive chemoradiation therapy, but with an excellent outcome. Early diagnosis and staging with high suspicion are crucial in malignant phyllodes tumor patients since they do not only improve the overall outcome of the disease after lumpectomy only but they also decrease morbidity and mortality with adjunctive chemoradiation therapy. This case report has been reported in line with the SCARE criteria (Agha et al., 2016 [1]). Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  19. Architecture and Stages of the Experience City

    DEFF Research Database (Denmark)

    This book presents more than 41 articles on ‘Architecture and Stages of the Experience City'. The aim of the book is to investigate current challenges related to architecture, art and city life in the ‘Experience City' and it is presenting cutting edge knowledge and experiences within the followi...... themes: Experience City Making Digital Architecture Stages in the Experience City The City as a Learning Lab Experience City Architecture Performative Architecture Art and Performance Urban Catalyst and Temporary Use......This book presents more than 41 articles on ‘Architecture and Stages of the Experience City'. The aim of the book is to investigate current challenges related to architecture, art and city life in the ‘Experience City' and it is presenting cutting edge knowledge and experiences within the following...

  20. Comparative myoanatomy of cycliophoran life cycle stages

    DEFF Research Database (Denmark)

    Neves, Ricardo C.; Cunha, Maria R.; Funch, Peter

    2010-01-01

    The metazoan phylum Cycliophora includes small cryptic epibionts that live attached to the mouthparts of clawed lobsters. The life cycle is complex, with alternating sexual and asexual generations, and involves several sessile and free-living stages. So far, the morphological and genetic...... on the dorsal side, whereas on the ventral side, longitudinal muscles and a V-shaped muscle structure are present. These muscles are complemented by additional dorsoventral muscles. The mesodermal muscle fibers attach to the cuticle via the epidermis in all life cycle stages studied herein. The musculature...... of the female is similar to that of the Pandora larva of Symbion americanus and includes dorsoventral muscles and longitudinal muscles that run in the dorsal and ventral body region. Overall, our results reveal striking similarities in the muscular arrangement of the life cycle stages of both Symbion species. J...

  1. Choreographic Programming

    DEFF Research Database (Denmark)

    Montesi, Fabrizio

    , as they offer a concise view of the message flows enacted by a system. For this reason, in the last decade choreographies have been used in the development of programming languages, giving rise to a programming paradigm that in this dissertation we refer to as Choreographic Programming. Recent studies show...... endpoint described in a choreography can then be automatically generated, ensuring that such implementations are safe by construction. However, current formal models for choreographies do not deal with critical aspects of distributed programming, such as asynchrony, mobility, modularity, and multiparty...... sessions; it remains thus unclear whether choreographies can still guarantee safety when dealing with such nontrivial features. This PhD dissertation argues for the suitability of choreographic programming as a paradigm for the development of safe distributed systems. We proceed by investigating its...

  2. The thesis of stages fourteen years later

    Science.gov (United States)

    Beeby, C. E.

    1980-12-01

    The author indicates the changes and additions he would make to his book ` The Quality of Education in Developing Countries' (1966) if he were re-writing it in 1980. He would make clearer that his primary interest is in a continuum of change, the process of growth of a school system, and that the `stages' are only a convenient non-mathematical artifact to make the thesis more useful to administrators and planners. In the light of more recent developments and experiences, he now gives new stress to the pluralism of objectives at the stage of Meaning, and discusses the political, social, cultural and financial reasons why a country may choose not to take the difficult step from stage III to stage IV. Recent forms of alternative education, particularly those embodying plans for lifelong education, offer some hope of bypassing his thesis of stages. More consideration is given to constraints other than that of teacher qualification, though the difficulty of changing the skills, habits, attitudes and purposes in the teaching profession remain the chief obstacle to qualitative growth. Particular attention is paid to `crash' programmes where processes that are, by their very nature, successive are compressed into simultaneous or almost simultaneous ones. Some implications of the thesis of stages for teacher training are briefly dealt with. Regarding the application of the thesis to secondary education, he maintains that a better model of growth would be one based on the capacity of secondary education to respond to the changing economic and social demands of the community. Finally, he suggests three methods of testing his hypotheses and pleads that more consideration be given to building up a body of educational, theory based on the experience of developing countries over the past three decades.

  3. Mars Ascent Vehicle-First Stage Motor

    Science.gov (United States)

    Dankanich, John; Doudrick, Scott; Williams, Jacob

    2015-01-01

    This project is development effort of a first stage solid motor based on a two-stage solid motor Mars Ascent Vehicle (MAV) design for the robotic Mars Sample Return (MSR) mission (fig. 1). The MSR MAV has been studied for decades and multiple concepts have been shown to meet the mission objectives as posed.1 However, there remains significant uncertainty with the MAV requirements. The sample container and sample cache itself is immature. Additionally, MAV-specific requirements ranging from full three-axis controlled and strict communication requirements to minimal capability concepts are still under consideration. Given the maturity of the overall mission requirements, the MAV has been limited to a large number of parametric analyses and paper studies. Recently, a Jet Propulsion Laboratory study highlighted the flexibility of a two-stage solid motor concept. The MAV itself is driven by the constraints of the Entry, Decent, and Landing (EDL) system. Within the EDL constraints, there is a range of MAV options ranging in complexity from simple spun upper stage options to higher capability three-axis controlled solutions. There are also options to trade the ratio of mission (Delta)V between the first and second stage. Finally, sensitivity studies also indicated that solid motors with a high percentage of off-load flexability only had minor impact on the total system mass over a single point design optimized motor. This flexibility in the first stage motor has allowed NASA to mature the design of the motor beyond parametric analyses and start to address known design challenges of the motor.

  4. Low Noise Research Fan Stage Design

    Science.gov (United States)

    Hobbs, David E.; Neubert, Robert J.; Malmborg, Eric W.; Philbrick, Daniel H.; Spear, David A.

    1995-01-01

    This report describes the design of a Low Noise ADP Research Fan stage. The fan is a variable pitch design which is designed at the cruise pitch condition. Relative to the cruise setting, the blade is closed at takeoff and opened for reverse thrust operation. The fan stage is a split flow design with fan exit guide vanes and core stators. This fan stage design was combined with a nacelle and engine core duct to form a powered fan/nacelle, subscale model. This model is intended for use in aerodynamic performance, acoustic and structural testing in a wind tunnel. The model has a 22-inch outer fan diameter and a hub-to-top ratio of 0.426 which permits the use of existing NASA fan and cowl force balance designs and rig drive system. The design parameters were selected to permit valid acoustic and aerodynamic comparisons with the PW 17-inch rig previously tested under NASA contract. The fan stage design is described in detail. The results of the design axisymmetric analysis at aerodynamic design condition are included. The structural analysis of the fan rotor and attachment is described including the material selections and stress analysis. The blade and attachment are predicted to have adequate low cycle fatigue life, and an acceptable operating range without resonant stress or flutter. The stage was acoustically designed with airfoil counts in the fan exit guide vane and core stator to minimize noise. A fan-FEGV tone analysis developed separately under NASA contract was used to determine these airfoil counts. The fan stage design was matched to a nacelle design to form a fan/nacelle model for wind tunnel testing. The nacelle design was developed under a separate NASA contract. The nacelle was designed with an axisymmetric inlet, cowl and nozzle for convenience in testing and fabrication. Aerodynamic analysis of the nacelle confirmed the required performance at various aircraft operating conditions.

  5. Development of Effective Teacher Program: Teamwork Building Program for Thailand's Municipal Schools

    Science.gov (United States)

    Chantathai, Pimpka; Tesaputa, Kowat; Somprach, Kanokorn

    2015-01-01

    This research is aimed to formulate the effective teacher teamwork program in municipal schools in Thailand. Primary survey on current situation and problem was conducted to develop the plan to suggest potential programs. Samples were randomly selected from municipal schools by using multi-stage sampling method in order to investigate their…

  6. Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer

    Science.gov (United States)

    2017-04-12

    Ovarian Sarcoma; Ovarian Stromal Cancer; Stage I Uterine Sarcoma; Stage I Vaginal Cancer; Stage I Vulvar Cancer; Stage IA Cervical Cancer; Stage IA Endometrial Carcinoma; Stage IA Fallopian Tube Cancer; Stage IA Ovarian Epithelial Cancer; Stage IA Ovarian Germ Cell Tumor; Stage IA Primary Peritoneal Cavity Cancer; Stage IB Cervical Cancer; Stage IB Endometrial Carcinoma; Stage IB Fallopian Tube Cancer; Stage IB Ovarian Epithelial Cancer; Stage IB Ovarian Germ Cell Tumor; Stage IB Primary Peritoneal Cavity Cancer; Stage IC Fallopian Tube Cancer; Stage IC Ovarian Epithelial Cancer; Stage IC Ovarian Germ Cell Tumor; Stage IC Primary Peritoneal Cavity Cancer; Stage II Endometrial Carcinoma; Stage II Gestational Trophoblastic Tumor; Stage II Uterine Sarcoma; Stage II Vaginal Cancer; Stage II Vulvar Cancer; Stage IIA Cervical Cancer; Stage IIA Fallopian Tube Cancer; Stage IIA Ovarian Epithelial Cancer; Stage IIA Ovarian Germ Cell Tumor; Stage IIA Primary Peritoneal Cavity Cancer; Stage IIB Cervical Cancer; Stage IIB Fallopian Tube Cancer; Stage IIB Ovarian Epithelial Cancer; Stage IIB Ovarian Germ Cell Tumor; Stage IIB Primary Peritoneal Cavity Cancer; Stage IIC Fallopian Tube Cancer; Stage IIC Ovarian Epithelial Cancer; Stage IIC Ovarian Germ Cell Tumor; Stage IIC Primary Peritoneal Cavity Cancer; Stage III Gestational Trophoblastic Tumor; Stage III Uterine Sarcoma; Stage III Vaginal Cancer; Stage III Vulvar Cancer; Stage IIIA Cervical Cancer; Stage IIIA Endometrial Carcinoma; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIA Primary Peritoneal Cavity Cancer; Stage IIIB Cervical Cancer; Stage IIIB Endometrial Carcinoma; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Epithelial Cancer; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIB Primary Peritoneal Cavity Cancer; Stage IIIC Endometrial Carcinoma; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Ovarian Germ Cell

  7. PLL with MAF-Based Prefiltering Stage

    DEFF Research Database (Denmark)

    Golestan, Saeed; Guerrero, Josep M.; Vidal, Ana

    2016-01-01

    , it suffers from a very poor performance in the detection of grid voltage parameters. To deal with this challenge, incorporating different filters inside its control loop or before its input has been proposed. Recently, using the moving average filter (MAF) as the SRF-PLL prefiltering stage has been suggested...... in several works. The MAF is a linear-phase filter that can behave like an ideal lowpass filter under certain conditions. The main aim of this letter is to derive the small-signal model of the SRF-PLL with MAF-based prefiltering stage (briefly called the PMAF-PLL), which has not been presented before...

  8. Radiotherapy versus combined modality in early stages

    DEFF Research Database (Denmark)

    Specht, L; Carde, P; Mauch, P

    1992-01-01

    In early stage Hodgkin's disease the optimal choice of treatment for the individual patient is still an unresolved issue. So far, twenty-two randomized trials of radiotherapy alone versus radiotherapy plus combination chemotherapy have been carried out worldwide. The preliminary results of a global...... be reduced, and that the stress of experiencing a relapse is avoided in many patients. The major argument against the use of chemotherapy up front is: that by careful staging and selection of patients and by careful radiotherapy techniques the number of patients exposed to potentially toxic chemotherapy may...

  9. Stages of change, treatment outcome and therapeutic alliance in adult inpatients with chronic anorexia nervosa.

    Science.gov (United States)

    Mander, Johannes; Teufel, Martin; Keifenheim, Katharina; Zipfel, Stephan; Giel, Katrin Elisabeth

    2013-04-09

    Anorexia nervosa (AN) is associated with high rates of chronicity and relapse risk is a considerable therapeutic challenge in the disorder. The aim of the present study was to investigate the association of stages of change and outcome with a focus on the relapse struggle in the maintenance stage in patients with predominantly chronic AN. Further, therapeutic alliance and stages of change associations were explored. As an instrument measuring relapse struggle in the maintenance stage, we applied the short form of the University of Rhode Island Change Assessment-Short (URICA-S). We assessed stages of change in 39 patients with a predominantly chronic course of AN in early, middle, and late stages of inpatient psychotherapy. General symptom severity as assessed by the SCL-90-R and weight change were investigated as outcome measures. In-line with earlier evidence, contemplation significantly predicted therapeutic alliance. Further, we demonstrated that relapse risk as operationalized by URICA-S maintenance is an important predictor of general psychopathology. BMI change was not predicted by stages of change. The URICA-S maintenance scale might be applied to help identify patients at relapse risk. High URICA-S maintenance scores could be considered as one critical aspect of AN patients who might especially benefit from relapse-preventing aftercare programs.

  10. AJCC-7TH Edition Staging Criteria for Colon Cancer: Do the Complex Modifications Improve Prognostic Assessment?

    Science.gov (United States)

    Hari, Danielle M; Leung, Anna M; Lee, Ji-Hey; Sim, Myung-Shin; Vuong, Brooke; Chiu, Connie G; Bilchik, Anton J

    2015-01-01

    Background The seventh edition of the American Joint Committee on Cancer staging system (AJCC-7) includes significant changes for colon cancer (CC), which are particularly complex in patients with stage II and III disease. We used a national cancer database to determine if these changes improved prediction of survival. Study Design The database of the Surveillance, Epidemiology, and End Results (SEER) Program was queried to identify patients with pathologically confirmed stage I-III CC diagnosed between 1988 and 2008. CC was staged by sixth edition AJCC criteria (AJCC-6) and then restaged by AJCC-7. Five-year disease-specific survival (DSS) and overall survival (OS) were compared. Results After all exclusion criteria were applied, AJCC-6 and AJCC-7 staging was possible in 157,588 patients (68.9%). Bowker's test of symmetry showed that the number of patients per substage was different for AJCC-6 and AJCC-7 (p 12 lymph nodes examined did not affect this observation. Conclusion AJCC-7 staging of CC does not address all survival discrepancies, regardless of the number of lymph nodes examined. Consideration of other prognostic factors is critical for decisions regarding therapy, particularly for patients with stage II CC. PMID:23768788

  11. A community-based breast cancer screening program for medically underserved women: its effect on disease stage at diagnosis and on hazard of death Programa basado en la comunidad de tamizaje de cáncer de mama en mujeres médicamente subatendidas: efecto sobre el estadio de la enfermedad en el momento del diagnóstico y el riesgo de muerte

    Directory of Open Access Journals (Sweden)

    Clyde B. McCoy

    2004-03-01

    Full Text Available OBJECTIVE: Earlier studies by this research team found that medically underserved minority women in the Miami-Dade County area of the state of Florida, United States, were in need of breast cancer screening and that there were problems with availability, accessibility, and acceptability of services. In response, a community-based comprehensive breast cancer screening program called the Early Detection Program (EDP was developed. The specific purpose of this study was to assess the effect that EDP participation had on stage at diagnosis and on hazard of death. METHODS: Existing data from the Florida Cancer Data System (FCDS, a statewide cancer registry, were linked with data from the EDP. In December 1998 we assembled a multiethnic (African-American, black Hispanic, white Hispanic, and white non-Hispanic retrospective cohort with the following inclusion criteria: all women aged 40 and older with breast cancer diagnosed and staged at University of Miami/Jackson Memorial Medical Center (which is located in the city of Miami, Florida from January 1987 through December 1997. EDP participants were medically underserved, that is, they resided in lower socioeconomic areas and/or had limited or no health insurance to cover medical costs. Subjects identified as EDP participants were compared to nonparticipants with respect to disease stage at diagnosis and hazard of death. Logistic regression and Cox regression models were used for analysis. RESULTS: EDP participants were 2.4 times as likely (95% confidence interval = 1.71 to 3.43 to present with a diagnosis of localized cancer as were nonparticipants, even after controlling for race and age at diagnosis. EDP participation was independently associated with both earlier diagnosis and reduced hazard of death. CONCLUSIONS: Participation in the EDP increases the likelihood of early detection of breast cancer and reduces the hazard of death for medically underserved women in the Miami-Dade County area of

  12. Achievement of control of bronchial asthma at the stage of medical rehabilitation

    Directory of Open Access Journals (Sweden)

    Grygus I.M.

    2011-02-01

    Full Text Available An inspection is conducted 70 patients on intermittent bronchial asthma at the stage of intensifying. The special program of medical rehabilitation, which includes the modified methods of medical physical culture, physical therapy facilities, is offered in permanent establishment. Application of this program brought to the height of size of Asthma Control Test from 17,41±0,35 to 24,03±0,32 points over. Control of flow of disease which did not come at treatment of patients only by medicinal preparations was arrived at in all cases of application of the program of medical rehabilitation.

  13. Collaborative applied research programs at AITF

    Energy Technology Data Exchange (ETDEWEB)

    Chow, Ross [Alberta Innovates Technology Futures (Canada)

    2011-07-01

    Alberta Innovates Technology Futures (AITF) is a 600 employee company created in 2010 and owned by the Alberta government; offices are located in Edmonton, Devon, Vegreville and Calgary. The purpose of this document is to present the services provided by AITF. The company provides technical support and advisory services as well as commercialization support, they provide the link between the concept stage and the commercialization stage. AITF proposes collaborative programs which can be consortia made up of a series of projects on general industry issues or joint industry projects which focus on a specific issue. During this presentation, a joint industry project, the fuels and lubricants exchange program, was presented along with several consortia such as the carbonate research program, the materials and reliability in oil sands program, and the AACI program. This presentation highlighted the work carried out by AITF to meet the needs of their clients.

  14. Installation Restoration Program. Volume 1. 110th Fighter Group Michigan Air National Guard, W.K. Kellogg Memorial Airport, Battle Creek, Michigan

    Science.gov (United States)

    1993-11-01

    PROJECT 1.0. ATlO3ICOORDINATES 3.63L.3 - E 4,097. N DRILLING STARTED 111318>8 ES GEOLOGIST/ENGINEER M. E. Hermnann DRILLER Fox Drillng DRILLING METHOD...1.2.1 Facility Description 1-4 1.2.2 Project Scope 1-5 1.3 Summary of Previous IRP Activities 1-6 1.4 IRP Site Identification and Description 1-6 1.4.1...groundwater samples. Site 3 - Fire Training Area is a bermed earthen area used for fire training 3 activities between 1977 and 1986. Wastes oils , jet fuel

  15. Accuracy of the One-Stage and Two-Stage Impression Techniques: A Comparative Analysis

    Directory of Open Access Journals (Sweden)

    Ladan Jamshidy

    2016-01-01

    Full Text Available Introduction. One of the main steps of impression is the selection and preparation of an appropriate tray. Hence, the present study aimed to analyze and compare the accuracy of one- and two-stage impression techniques. Materials and Methods. A resin laboratory-made model, as the first molar, was prepared by standard method for full crowns with processed preparation finish line of 1 mm depth and convergence angle of 3-4°. Impression was made 20 times with one-stage technique and 20 times with two-stage technique using an appropriate tray. To measure the marginal gap, the distance between the restoration margin and preparation finish line of plaster dies was vertically determined in mid mesial, distal, buccal, and lingual (MDBL regions by a stereomicroscope using a standard method. Results. The results of independent test showed that the mean value of the marginal gap obtained by one-stage impression technique was higher than that of two-stage impression technique. Further, there was no significant difference between one- and two-stage impression techniques in mid buccal region, but a significant difference was reported between the two impression techniques in MDL regions and in general. Conclusion. The findings of the present study indicated higher accuracy for two-stage impression technique than for the one-stage impression technique.

  16. Comparison between a two-stage and single-stage digesters when ...

    African Journals Online (AJOL)

    Phenol is a pollutant found in many industrial wastewaters, which diminishes biogas formation in anaerobic digesters. In this study, a two-stage (acidogenic and methanogenic) anaerobic digester (TSAD) was compared to a single stage digester (SSD), in treating a synthetic wastewater contaminated with phenol.

  17. Discrepancy between clinical staging through bimanual palpation and pathological staging after cystectomy.

    NARCIS (Netherlands)

    Ploeg, M.; Kiemeney, L.A.L.M.; Smits, G.A.H.J.; Vergunst, H.; Viddeleer, A.C.; Geboers, A.D.; Berkel, H. van; Boven, E.; Aben, K.K.H.; Witjes, J.A.

    2012-01-01

    OBJECTIVES: In muscle invasive bladder cancer (MIBC), careful clinical staging is essential for patient counseling and decision-making. Bimanual palpation (BP) is an integral part and guideline advice of clinical staging. Until now, however, the value of BP has never been studied. With this study,

  18. Treatment results in women with clinical stage I and pathologic stage II endometrial carcinoma

    NARCIS (Netherlands)

    Jobsen, J.J.; Schutter, E.M.J.; Meerwaldt, J.H.; van der Palen, Jacobus Adrianus Maria; van der Sijde, R.; Naudin ten Cate, L.

    2001-01-01

    The aim of this study is to report survival and results of therapy and possible prognostic factors in women with pathologic stage II endometrial carcinoma. Forty-two patients with pathologic stage II endometrial carcinoma were treated at the department of Radiation Oncology of the Medisch Spectrum

  19. Laparoscopic staging for apparent stage I epithelial ovarian cancer.

    Science.gov (United States)

    Melamed, Alexander; Keating, Nancy L; Clemmer, Joel T; Bregar, Amy J; Wright, Jason D; Boruta, David M; Schorge, John O; Del Carmen, Marcela G; Rauh-Hain, J Alejandro

    2017-01-01

    Whereas advances in minimally invasive surgery have made laparoscopic staging technically feasible in stage I epithelial ovarian cancer, the practice remains controversial because of an absence of randomized trials and lack of high-quality observational studies demonstrating equivalent outcomes. This study seeks to evaluate the association of laparoscopic staging with survival among women with clinical stage I epithelial ovarian cancer. We used the National Cancer Data Base to identify all women who underwent surgical staging for clinical stage I epithelial ovarian cancer diagnosed from 2010 through 2012. The exposure of interest was planned surgical approach (laparoscopy vs laparotomy), and the primary outcome was overall survival. The primary analysis was based on an intention to treat: all women whose procedures were initiated laparoscopically were categorized as having had a planned laparoscopic procedure, regardless of subsequent conversion to laparotomy. We used propensity methods to match patients who underwent planned laparoscopic staging with similar patients who underwent planned laparotomy based on observed characteristics. We compared survival among the matched cohorts using the Kaplan-Meier method and Cox regression. We compared the extent of lymphadenectomy using the Wilcoxon rank-sum test. Among 4798 eligible patients, 1112 (23.2%) underwent procedures that were initiated laparoscopically, of which 190 (17%) were converted to laparotomy. Women who underwent planned laparoscopy were more frequently white, privately insured, from wealthier ZIP codes, received care in community cancer centers, and had smaller tumors that were more frequently of serous and less often of mucinous histology than those who underwent staging via planned laparotomy. After propensity score matching, time to death did not differ between patients undergoing planned laparoscopic vs open staging (hazard ratio, 0.77, 95% confidence interval, 0.54-1.09; P = .13). Planned

  20. Programming Python

    CERN Document Server

    Lutz, Mark

    2011-01-01

    If you've mastered Python's fundamentals, you're ready to start using it to get real work done. Programming Python will show you how, with in-depth tutorials on the language's primary application domains: system administration, GUIs, and the Web. You'll also explore how Python is used in databases, networking, front-end scripting layers, text processing, and more. This book focuses on commonly used tools and libraries to give you a comprehensive understanding of Python's many roles in practical, real-world programming. You'll learn language syntax and programming techniques in a clear and co

  1. Hypofractionated Radiation Therapy in Treating Patients With Stage 0-IIB Breast Cancer

    Science.gov (United States)

    2017-12-05

    Ductal Breast Carcinoma In Situ; Invasive Breast Carcinoma; Stage 0 Breast Cancer; Stage I Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer

  2. Inclusiveness program - a SWOT analysis

    Science.gov (United States)

    Dósa, M.; Szegő, K.

    2017-09-01

    The Inclusiveness Program was created with the aim to integrate currently under-represented countries into the mainstream of European planetary research. Main stages of the working plan include setting up a database containing all the research institutes and universities where astronomical or geophysical research is carried out. It is necessary to identify their problems and needs. Challenging part of the project is to find exact means that help their work in a sustainable way. Strengths, weaknesses, opportunities and threats of the program were identified based on feedback from the inclusiveness community. Our conclusions, further suggestions are presented.

  3. Optimization, an Important Stage of Engineering Design

    Science.gov (United States)

    Kelley, Todd R.

    2010-01-01

    A number of leaders in technology education have indicated that a major difference between the technological design process and the engineering design process is analysis and optimization. The analysis stage of the engineering design process is when mathematical models and scientific principles are employed to help the designer predict design…

  4. Ares I First Stage: Powering Exploration

    Science.gov (United States)

    Tiller, Bruce K.

    2009-01-01

    I. Ares First Stage design is on schedule. a) Avionics; b) Major Structures; c) Motor; and d) Deceleration System II. Ares I-X hardware is complete and assembly at KSC is underway. Launch scheduled for October 31. III. Recovery system testing is on schedule a) Drogue; b) Main chute; and c) Cluster. DM-1 static firing is scheduled for August 25, 2009

  5. Performance of 8-stage Multianode Photomultipliers

    CERN Document Server

    Eisenhardt, S

    2005-01-01

    64-channel Multianode Photomultiplier (MaPMT) have been evaluated as a candidate photo detector for the LHCb Ring Imaging Cherenkov (RICH) counters. The newly available 8-dynode stage MaPMT were tested with particle beams at CERN. The MaPMT signals were read out directly by the Beetle 1.2 chip which is designed for silicon sensors operating at 40 MHz. The photon yield and signal loss in a cluster of 3x3 close-packed MaPMTs were determined and preliminary results matched expectations from simulations. The performance of the 8-stage MaPMT was compared to that of the 12-stage MaPMT which has a larger intrinsic gain. For the read out the Beetle 1.2MA0 chip has been designed to match the dynamic range of the 12-stage MaPMT. In addition by using a LED light source the performance of the MaPMTs was tested in magnetic fields up to 35 mT. In measurements without and with mu-metal shielding we determined the magnetic field in which the tubes still can be operated with 90% signal efficiency.

  6. Behaviorism and the Stages of Scientific Activity

    Science.gov (United States)

    Moore, J.

    2010-01-01

    Following from an earlier analysis by B. F. Skinner, the present article suggests that the verbal processes in science may usefully be viewed as following a three-stage progression. This progression starts with (a) identification of basic data, then moves to (b) description of relations among those data, and ultimately concludes with (c) the…

  7. Capacitor blocks for linear transformer driver stages.

    Science.gov (United States)

    Kovalchuk, B M; Kharlov, A V; Kumpyak, E V; Smorudov, G V; Zherlitsyn, A A

    2014-01-01

    In the Linear Transformer Driver (LTD) technology, the low inductance energy storage components and switches are directly incorporated into the individual cavities (named stages) to generate a fast output voltage pulse, which is added along a vacuum coaxial line like in an inductive voltage adder. LTD stages with air insulation were recently developed, where air is used both as insulation in a primary side of the stages and as working gas in the LTD spark gap switches. A custom designed unit, referred to as a capacitor block, was developed for use as a main structural element of the transformer stages. The capacitor block incorporates two capacitors GA 35426 (40 nF, 100 kV) and multichannel multigap gas switch. Several modifications of the capacitor blocks were developed and tested on the life time and self breakdown probability. Blocks were tested both as separate units and in an assembly of capacitive module, consisting of five capacitor blocks. This paper presents detailed design of capacitor blocks, description of operation regimes, numerical simulation of electric field in the switches, and test results.

  8. Stages of AIDS-Related Lymphoma

    Science.gov (United States)

    ... depend on the following: The stage of the cancer. The age of the patient. The number of CD4 lymphocytes (a type of white blood cell) in the blood. The number of places in the body lymphoma is found outside the lymph ... tests are done to find out if cancer cells have spread within the lymph system or ...

  9. Treatment of early-stage Hodgkin lymphoma

    NARCIS (Netherlands)

    Engert, A.; Raemaekers, J.M.M.

    2016-01-01

    Hodgkin lymphoma (HL) has become one of the best curable malignancies today. This is particularly true for patients with early-stage disease. Today, most patients in this risk group are treated with a combination of chemotherapy followed by small-field radiotherapy. More recent clinical trials such

  10. Predicting Stages of Change in Battered Women

    Science.gov (United States)

    Alexander, Pamela C.; Tracy, Allison; Radek, Megan; Koverola, Catherine

    2009-01-01

    Battered women's stages of change (SOCs) are examined in this study. First, confirmatory factor analysis and latent profile analysis were conducted on 754 battered women's responses on the Problems in Relationship Scale (Brown, 1998). Factor loadings were strong, and latent variable mixture modeling produces a two-class solution. Second,…

  11. Multi-stage LTL transport systems in supply chain management

    OpenAIRE

    Gonzalez-Feliu, Jesus

    2013-01-01

    This paper aims to unify concepts and to describe the multi-stage transport systems and their integratyion to supply chain management. Multi-stage distribution systems are common logistics management, and often they are assimilated to multi-stage transport strategies. However, transport is often considered as an external operation or a specific stage, even when it is a multi-stage system. First, the paper presents the main concepts of multi-stage transport systems by defining the concept an m...

  12. Space Launch System Upper Stage Technology Assessment

    Science.gov (United States)

    Holladay, Jon; Hampton, Bryan; Monk, Timothy

    2014-01-01

    The Space Launch System (SLS) is envisioned as a heavy-lift vehicle that will provide the foundation for future beyond low-Earth orbit (LEO) exploration missions. Previous studies have been performed to determine the optimal configuration for the SLS and the applicability of commercial off-the-shelf in-space stages for Earth departure. Currently NASA is analyzing the concept of a Dual Use Upper Stage (DUUS) that will provide LEO insertion and Earth departure burns. This paper will explore candidate in-space stages based on the DUUS design for a wide range of beyond LEO missions. Mission payloads will range from small robotic systems up to human systems with deep space habitats and landers. Mission destinations will include cislunar space, Mars, Jupiter, and Saturn. Given these wide-ranging mission objectives, a vehicle-sizing tool has been developed to determine the size of an Earth departure stage based on the mission objectives. The tool calculates masses for all the major subsystems of the vehicle including propellant loads, avionics, power, engines, main propulsion system components, tanks, pressurization system and gases, primary structural elements, and secondary structural elements. The tool uses an iterative sizing algorithm to determine the resulting mass of the stage. Any input into one of the subsystem sizing routines or the mission parameters can be treated as a parametric sweep or as a distribution for use in Monte Carlo analysis. Taking these factors together allows for multi-variable, coupled analysis runs. To increase confidence in the tool, the results have been verified against two point-of-departure designs of the DUUS. The tool has also been verified against Apollo moon mission elements and other manned space systems. This paper will focus on trading key propulsion technologies including chemical, Nuclear Thermal Propulsion (NTP), and Solar Electric Propulsion (SEP). All of the key performance inputs and relationships will be presented and

  13. Human Immunodeficiency Virus Research Program

    Science.gov (United States)

    1993-11-30

    assessment of periodontal changes relative to Walter Reed Staging and CD4/CD8 counts, as well as other co-factors, such as smoking . Assessment of soft...Some commonly held concepts that have greatly influenced the course of HIV-1 vaccine research in the past and that are pertinent to this program are...criteria for reduced severity of disease and transmission potential using an integrated immunologic, virologic, and structural analysis of lymphoid tissues

  14. SOME ASPECTS OF THE GEORGIAN ECONOMY AT THE CONTEMPORARY STAGE

    Directory of Open Access Journals (Sweden)

    Tamaz ZUBIASHVILI

    2016-08-01

    Full Text Available In the former Soviet Union the economy of the Georgian Republic occupied advanced positions. At the very first stage of the restoration of independence the post-Soviet Georgia’s economy declined 3-times; in the following years, the situation improved, but it reached the 1990 level only after 15 years. In spite of difficult problems of development it should be singled out the middle period progress of the 90-ies when the country introduced a new currency - Lari, created conditions for attracting foreign investments, economic growth was expressed in double-digit figures; it created an independent banking system, rapidly implemented the program of privatization, strengthened the links with international financial organizations and others. By this time, the private sector’s share in the state budget revenues was already 80%. After the end of the 90-ies, in a few years, economic reforms stalled. After the “Rose Revolution” - until 2012, the development of economy was greatly influenced by tightened administrative methods, foreign loans, foreign investment, and so forth. Unfortunately, at this stage of development, a property encroachment for the government became common practice in such a way as pressure on business. In recent four years, more attention was paid to the actual development, deepening of integration with European Union, the governmental pressure on business was removed. However, because of the lack of jobs, labour force continues to flow abroad.

  15. Programming Python

    National Research Council Canada - National Science Library

    Lutz, Mark

    2006-01-01

    ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3 3 8 9 15 17 20 22 2. A Sneak Preview "Programming Python: The Short Story" The Task Step 1: Representing Records Step 2: Storing Records Persistently Step 3...

  16. Linear programming

    CERN Document Server

    Solow, Daniel

    2014-01-01

    This text covers the basic theory and computation for a first course in linear programming, including substantial material on mathematical proof techniques and sophisticated computation methods. Includes Appendix on using Excel. 1984 edition.

  17. Method and system for dual resolution translation stage

    Science.gov (United States)

    Halpin, John Michael

    2014-04-22

    A dual resolution translation stage includes a stage assembly operable to receive an optical element and a low resolution adjustment device mechanically coupled to the stage assembly. The dual resolution stage also includes an adjustable pivot block mechanically coupled to the stage assembly. The adjustable pivot block includes a pivot shaft. The dual resolution stage further includes a lever arm mechanically coupled to the adjustable pivot block. The lever arm is operable to pivot about the pivot shaft. The dual resolution stage additionally includes a high resolution adjustment device mechanically coupled to the lever arm and the stage assembly.

  18. Extent of pelvic lymphadenectomy and use of adjuvant vaginal brachytherapy for early-stage endometrial cancer.

    Science.gov (United States)

    Matsuo, Koji; Machida, Hiroko; Ragab, Omar M; Takiuchi, Tsuyoshi; Pham, Huyen Q; Roman, Lynda D

    2017-03-01

    To examine trends of adjuvant radiotherapy choice and to examine associations between pelvic lymphadenectomy and radiotherapy choice for women with early-stage endometrial cancer. The Surveillance, Epidemiology, and End Results Program was used to identify surgically treated stage I-II endometrial cancer between 1983 and 2012 (type 1 n=79,474, and type 2 n=25,020). Piecewise linear regression models were used to examine temporal trends of intracavitary brachytherapy (ICBT) and whole pelvic radiotherapy (WPRT) use, pelvic lymphadenectomy rate, and sampled node counts. Multivariable binary logistic regression models were used to identify independent predictors for ICBT use. There was a significant increase in ICBT use and decrease in WPRT use during the study period. ICBT use exceeded WPRT use in 2003 for type 1 stage IA, and in 2007 for type 1 stage IB and type 2 stage IA diseases. In addition, number of sampled pelvic nodes significantly increased over time in type 1-2 stage I-II diseases (mean, 7.0-12.7 in 1988 to 15.2-17.6 in 2012, all P10 nodes versus no lymphadenectomy in stage IA (1.38/2.40), IB (2.75/6.32), and II (1.36/2.91) diseases. Similar trends were observed for type 2 cancer: adjusted-odds ratios for stage IA (1.69/3.73), IB (2.25/5.65), and II (1.36/2.19) diseases. Our results suggest that surgeons and radiation oncologists are evaluating the extent of pelvic lymphadenectomy when counseling women with early-stage endometrial cancer for adjuvant radiotherapy. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Stages of change, determinants, and mortality for smoking cessation in adult Taiwanese screenees.

    Science.gov (United States)

    Luh, Dih-Ling; Chen, Hsiu-Hsi; Liao, Long-Ren; Chen, Sam Li-Sheng; Yen, Amy Ming-Fang; Wang, Ting-Ting; Chiu, Sherry Yueh-Hsia; Fann, Ching-Yuan

    2015-02-01

    We aimed to investigate the associations between three smoking-related constructs (pros and cons of smoking, temptation to smoke, and self-efficacy of resisting smoking) and stage of change (precontemplation, contemplation, preparation, and action) based on the transtheoretical model among smokers attending a community-based screening program. We also assessed their effects on long-term all-cause mortality. A prospective cohort study, with an average of 7 years of follow-up, was conducted by enrolling 454 male smoking screenees. The comparisons of the mean score of each variable pertaining to three smoking-related constructs across four stages of smoking cessation were assessed by analysis of variance. The impacts of both smoking-related constructs and smoking cessation stage measured at baseline on 7-year mortality were assessed by using proportional hazards regression model. The differences in the mean scores of pros and cons of smoking, temptation to smoke, and self-efficacy of resisting smoking across four stages of smoking cessation were statistically significant (P stage, and low self-efficacy was independently predictive of long-term mortality among male smokers attending a community-based screening program.

  20. The Benefit of Baseline Staging-Risk Assessment of Distant Breast Cancer Metastases by Tumor Stage.

    Science.gov (United States)

    Rios, Nelmin; Adaskina, Nina; Frömke, Cornelia; Papendorf, Frank; Schippert, Cordula; Koch, Armin; Hillemanns, Peter; Park-Simon, Tjoung-Won

    2016-09-01

    Despite recommendations of international societies, use of baseline staging in breast cancer varies considerably. We retrospectively analyzed the prevalence of metastases in each pTN stage to estimate the benefit of staging. The prevalence of metastases at primary diagnosis (M1) and in the first year after diagnosis (M112) was determined in 2,906 patients. The prevalence of M1 was 0.95% [95% confidence interval (CI)=0.53-1.70%] in pT1pN0, 2.17% (95% CI=1.00-4.64) in pT1pN1 and 1.53% (95% CI=0.78-2.99%) in pT2pN0. The prevalence of M112 was 2.17% (95% CI=1.47-3.18%) in pT1pN0 and 3.25% in pathological stage IIA (upper confidence bound 5.14%). In pT2pN1 the prevalence of M1 and M112 was 3.49% (95% CI=1.96-6.14%) and 6.35% (95% CI=4.15-9.60%), respectively. Results for stage pT3pN0 and higher were inconclusive. Baseline staging can be safely abandoned in pathological stage I and IIA. Individual decisions should be made for pT2pN1. Staging is recommended in stages of pT3pN0 or higher. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  1. Nociones de la programacion de lenguas extranjeras (Ensayo metodologico) (Programming Foreign Languages [A Methodological Study])

    Science.gov (United States)

    Feldman, David

    1975-01-01

    Stresses the importance of language laboratories and other technical devices used in foreign language teaching, particularly in programed language instruction. Illustrates, by means of taxonomies, the various stages a foreign language learning program should follow. (Text is in Spanish.) (DS)

  2. Stage distribution of breast cancer diagnosed before and after implementation of population-based mammographic screening

    Energy Technology Data Exchange (ETDEWEB)

    Hofvind, S. [Cancer Registry of Norway, Oslo (Norway). Research; Skaane, P. [Oslo Univ. Hospital Ullevaal (Norway). Dept. of Radiology

    2012-05-15

    Purpose: The German mammographic screening program is very similar to the Norwegian Breast Cancer Screening Program (NBCSP), which started about 10 years earlier. This study analyzes the stage distribution of invasive breast cancers diagnosed in the pre-screening and screening period, and evaluates the overall mortality in women aged 55 - 74 in the pilot and non-pilot counties of the NBCSP. Materials and Methods: The NBCSP invites women aged 50 - 69 to participate in two-view mammography biennially. Chi-square statistics were used to compare percentages of the stage and treatment of invasive breast cancers diagnosed in women residing in the four pilot counties in the pre-screening (1984 - 1995) and screening (1996 - 2007) period. An ecological approach was used to analyze the age-specific mortality in the pilot and non-pilot counties for the period 1970 - 2007. Results: 50 % of the breast cancers diagnosed in the pre-screening period, 70 % of the cases detected with screening, 43 % of the interval cancers, and 52 % of the cancers diagnosed outside the NBCSP were stage I. Stage III + was present in 11 % of the cancers in the pre-screening period, and in 1 % of the cancers detected with screening. In the screening period, the breast cancer mortality rate decreased substantially more in the pilot counties than in the non-pilot counties. Conclusion: The stage distribution of breast cancer diagnosed in the NBCSP is prognostically favorable compared to cancers diagnosed outside the screening program. The reduction in the breast cancer mortality rate was more pronounced in the four pilot counties compared to the non-pilot counties. It is necessary to evaluate the program based on individual data. (orig.)

  3. Estágio de prontidão para mudança de comportamento de adolescentes interessados em ingressar no Programa Multiprofissional de Tratamento da Obesidade Estadio de prontitud para cambio de comportamiento de adolescentes interesados en ingresar en el Programa Multiprofesional de Tratamiento de la Obesidad Stage of readiness to change of behavior in adolescents interested in joining the Multiprofessional Obesity Treatment Program

    Directory of Open Access Journals (Sweden)

    Luzia Jaeger Hintze

    2012-06-01

    Full Text Available OBJETIVO: Avaliar o estágio de prontidão para mudança do comportamento (EPMC alimentar e de atividade física de adolescentes e verificar a associação entre as variáveis gênero, faixa etária e classificação do índice de massa corpórea (IMC com o EPMC. MÉTODOS: Foram avaliados 145 adolescentes entre dez e 18 anos interessados em ingressar no Programa Multiprofissional de Tratamento da Obesidade (PMTO. As avaliações incluíram, além dos EPMC, parâmetros antropométricos. A análise estatística envolveu a aplicação do teste t de Student para amostras independentes e do teste de Mann-Whitney na comparação entre os grupos. O teste do qui-quadrado de tendência foi utilizado para verificar se houve ou não associação entre as variáveis do estudo, sendo significante pOBJETIVO: Evaluar el estadio de prontitud para cambio del comportamiento (EPMC alimentar y de actividad física de adolescentes y verificar la asociación entre las variables género, franja de edad y clasificación del índice de masa corporal (IMC con los EPMC. MÉTODOS: Se evaluó a 145 adolescentes entre 10 y 18 años interesados en ingresar en el Programa Multiprofesional de Tratamiento de la Obesidad (PMTO. Las evaluaciones incluyeron, además de los EPMC, parámetros antropométricos. El análisis estadístico involucró la aplicación de la prueba t de Student para muestras independientes y de la prueba de Mann-Whitney en la comparación entre los grupos. La prueba del chi cuadrado de tendencia fue utilizada para verificar si hubo o no asociación entre las variables del estudio, siendo significante pOBJECTIVE: To access the stage of readiness to change (SRC dietary and physical activity behavior in adolescents and verify the association between the variables gender, age, body mass index (BMI classification and the SRC. METHODS: 145 adolescents aged from ten to 18 years interested in joining the Multiprofessional Obesity Treatment Program were evaluated

  4. Army Programs: Army Energy Program

    Science.gov (United States)

    1997-02-03

    the Energy Program. o Expands the responsibilities of the Assistant Chief of Staff for Installation Management (para 1-4). o Includes ridesharing as...not been highlighted. Summary. This regulation establishes poli- cies, procedures, and responsibilities for the Army Energy Program. Applicability ...Energy Technology Service (FETS) • 3–13, page 6 Energy Surveys • 3–14, page 6 Army Energy Awareness Seminars • 3–15, page 6 Army ridesharing • 3–16

  5. A Copositive Approach for Two-Stage Adjustable Robust Optimization with Uncertain Right-Hand Sides

    OpenAIRE

    Xu, Guanglin; Burer, Samuel

    2016-01-01

    We study two-stage adjustable robust linear programming in which the right-hand sides are uncertain and belong to a convex, compact uncertainty set. This problem is NP-hard, and the affine policy is a popular, tractable approximation. We prove that under standard and simple conditions, the two-stage problem can be reformulated as a copositive optimization problem, which in turn leads to a class of tractable, semidefinite-based approximations that are at least as strong as the affine policy. W...

  6. Technical Service Agreement (TSA) | FNLCR Staging

    Science.gov (United States)

    Frederick National Lab for Cancer Research (FNLCR)scientists provide services and solutions to collaborators through the Technical Services Program, whose portfolio includes more than200 collaborations with more than 80 partners such as t

  7. Space Launch System, Core Stage, Structural Test Design and Implementation

    Science.gov (United States)

    Shaughnessy, Ray

    2017-01-01

    As part of the National Aeronautics and Space Administration's (NASA) Space Launch System (SLS) Program, engineers at NASA's Marshall Space Flight Center (MSFC) in Huntsville, Alabama are working to design, develop and implement the SLS Core Stage structural testing. The SLS will have the capability to return humans to the Moon and beyond and its first launch is scheduled for December of 2017. The SLS Core Stage consist of five major elements; Forward Skirt, Liquid Oxygen (LOX) tank, Intertank (IT), Liquid Hydrogen (LH2) tank and the Engine Section (ES). Structural Test Articles (STA) for each of these elements are being designed and produced by Boeing at Michoud Assembly Facility located in New Orleans, La. The structural test for the Core Stage STAs (LH2, LOX, IT and ES) are to be conducted by the MSFC Test Laboratory. Additionally, the MSFC Test Laboratory manages the Structural Test Equipment (STE) design and development to support the STAs. It was decided early (April 2012) in the project life that the LH2 and LOX tank STAs would require new test stands and the Engine Section and Intertank would be tested in existing facilities. This decision impacted schedules immediately because the new facilities would require Construction of Facilities (C of F) funds that require congressional approval and long lead times. The Engine Section and Intertank structural test are to be conducted in existing facilities which will limit lead times required to support the first launch of SLS. With a SLS launch date of December, 2017 Boeing had a need date for testing to be complete by September of 2017 to support flight certification requirements. The test facilities were required to be ready by October of 2016 to support test article delivery. The race was on to get the stands ready before Test Article delivery and meet the test complete date of September 2017. This paper documents the past and current design and development phases and the supporting processes, tools, and

  8. [Treatment of early stage Hodgkin disease

    DEFF Research Database (Denmark)

    Specht, Lena; Carde, P.; Mauch, P.

    1993-01-01

    In early stage Hodgkin's disease the optimal choice of treatment is still an unresolved issue. Twenty-two randomized trials of radiotherapy alone versus radiotherapy plus combination chemotherapy have been carried out world-wide. The preliminary results of a global meta-analysis of these trials...... a relapse is avoided in many patients. The major argument against early chemotherapy is: that by careful staging and selection of patients and by careful radiotherapy techniques the number of patients exposed to potentially toxic chemotherapy may be kept at a minimum. Recently, trials have been carried out...... indicate that we still do not definitively know whether or not the early addition of prophylactic chemotherapy improves survival. Arguments in favour of early chemotherapy are: that laparotomy may be avoided, that radiation fields and doses may perhaps be reduced, and that the stress of experiencing...

  9. Early diagnosis of early stage lung cancer

    Directory of Open Access Journals (Sweden)

    Andrej Debeljak

    2005-11-01

    Full Text Available Background: For the detection of premalignant changes of bronchial mucosa and early stages of lung cancer frequent chest X-ray, spiral low dose computed tomography, fluorescence bronchoscopy, sputum cytology (also with automated systems with genetic and molecular changes in the sputum cells and bronchial mucosa were used. These screening methods of the high-risk groups for lung cancer achieved: earlier diagnosis of lung cancer in lower stage, higher operability, longer 5-year survival, but without mortality reduction.Conclusions: In the clinical practice we can examine higher risk groups for lung cancer in randomised control trials with multimodality approach: frequent chest low-dose fast spiral computed tomography, sputum cytology with genetic and molecular examinations and fluorescence bronchoscopy. Smoking cessation remains the best means to achieve mortality reduction from lung cancer.

  10. Second-stage turbine bucket airfoil

    Science.gov (United States)

    Wang, John Zhiqiang; By, Robert Romany; Sims, Calvin L.; Hyde, Susan Marie

    2002-01-01

    The second-stage buckets have airfoil profiles substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in inches in Table I wherein Z is a perpendicular distance from a plane normal to a radius of the turbine centerline and containing the X and Y values with the Z value commencing at zero in the X, Y plane at the radially innermost aerodynamic section of the airfoil and X and Y are coordinate values defining the airfoil profile at each distance Z. The X and Y values may be scaled as a function of the same constant or number to provide a scaled-up or scaled-down airfoil section for the bucket. The second-stage wheel has sixty buckets.

  11. Detailed experimental results for laser acceleration staging

    Directory of Open Access Journals (Sweden)

    W. D. Kimura

    2001-10-01

    Full Text Available Detailed experimental results of staging two laser-driven, relativistic electron accelerators are presented. During the experiment called STELLA (staged electron laser acceleration, an inverse free-electron laser (IFEL is used to modulate the electron energy, thereby, causing ∼3 fs microbunches to form separated by the laser wavelength at 10.6 μm (equivalent to a 35 fs period. A second IFEL accelerates the electrons depending upon the phase of the microbunches entering the second IFEL with respect to the laser beam driving the second IFEL. The data presented includes electron energy spectra as a function of the phase delay and laser power driving the first IFEL. Also shown is a comparison with the computer model, which includes space charge and misalignment effects.

  12. Whole organism blood stage vaccines against malaria.

    Science.gov (United States)

    Stanisic, Danielle I; Good, Michael F

    2015-12-22

    Despite a century of research focused on the development and implementation of effective control strategies, infection with the malaria parasite continues to result in significant morbidity and mortality worldwide. An effective malaria vaccine is considered by many to be the definitive solution. Yet, after decades of research, we are still without a vaccine that is capable of inducing robust, long lasting protection in naturally exposed individuals. Extensive sub-unit vaccine development focused on the blood stage of the malaria parasite has thus far yielded disappointing results. There is now a renewed focus on whole parasite vaccine strategies, particularly as they may overcome some of the inherent weaknesses deemed to be associated with the sub-unit approach. This review discusses the whole parasite vaccine strategy focusing on the blood stage of the malaria parasite, with an emphasis on recent advances and challenges in the development of killed and live attenuated vaccines. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Sleep Stage Classification Using Unsupervised Feature Learning

    Directory of Open Access Journals (Sweden)

    Martin Längkvist

    2012-01-01

    Full Text Available Most attempts at training computers for the difficult and time-consuming task of sleep stage classification involve a feature extraction step. Due to the complexity of multimodal sleep data, the size of the feature space can grow to the extent that it is also necessary to include a feature selection step. In this paper, we propose the use of an unsupervised feature learning architecture called deep belief nets (DBNs and show how to apply it to sleep data in order to eliminate the use of handmade features. Using a postprocessing step of hidden Markov model (HMM to accurately capture sleep stage switching, we compare our results to a feature-based approach. A study of anomaly detection with the application to home environment data collection is also presented. The results using raw data with a deep architecture, such as the DBN, were comparable to a feature-based approach when validated on clinical datasets.

  14. Two-stage sampling for acceptance testing

    Energy Technology Data Exchange (ETDEWEB)

    Atwood, C.L.; Bryan, M.F.

    1992-09-01

    Sometimes a regulatory requirement or a quality-assurance procedure sets an allowed maximum on a confidence limit for a mean. If the sample mean of the measurements is below the allowed maximum, but the confidence limit is above it, a very widespread practice is to increase the sample size and recalculate the confidence bound. The confidence level of this two-stage procedure is rarely found correctly, but instead is typically taken to be the nominal confidence level, found as if the final sample size had been specified in advance. In typical settings, the correct nominal [alpha] should be between the desired P(Type I error) and half that value. This note gives tables for the correct a to use, some plots of power curves, and an example of correct two-stage sampling.

  15. Two-stage sampling for acceptance testing

    Energy Technology Data Exchange (ETDEWEB)

    Atwood, C.L.; Bryan, M.F.

    1992-09-01

    Sometimes a regulatory requirement or a quality-assurance procedure sets an allowed maximum on a confidence limit for a mean. If the sample mean of the measurements is below the allowed maximum, but the confidence limit is above it, a very widespread practice is to increase the sample size and recalculate the confidence bound. The confidence level of this two-stage procedure is rarely found correctly, but instead is typically taken to be the nominal confidence level, found as if the final sample size had been specified in advance. In typical settings, the correct nominal {alpha} should be between the desired P(Type I error) and half that value. This note gives tables for the correct a to use, some plots of power curves, and an example of correct two-stage sampling.

  16. Staging Lung Cancer: Current Controversies and Strategies

    Directory of Open Access Journals (Sweden)

    Riyad Karmy-Jones

    1997-01-01

    Full Text Available A consistent approach to staging is required for the rational management of lung cancer. This paper was prepared at the request of the Standards Committee of the Canadian Thoracic Society, and reviews and discusses the relative merits of the available methods of staging. Whichever methods are chosen by a particular institution, the following points must be stressed. No patient can be considered automatically "unresectable" when chest radiography and/ or computed tomography demonstrate adenopathy or only suggest local invasion. Clinical and/or radiographical evidence suggesting extensive local or metastatic disease should be evaluated as completely as possible before subjecting the patient to a possible "nontherapeutic" thoracotomy. Finally, in some cases thoracotomy is required to decide whether the lesion is "completely" resectable.

  17. Stage dependent nutritional regulation of transgenerational longevity.

    Science.gov (United States)

    Roussou, Ilianna G; Savakis, Charalambos; Tavernarakis, Nektarios; Metaxakis, Athanasios

    2016-10-27

    BACKGROUND: Statistical analyses in human populations have associated limited food availability during development with increased longevity of next generations. In support, recent findings in Caenorhabditis elegans revealed nutritional effects on transgenerational longevity. OBJECTIVES: In this study we tested the effect of nutrition on longevity of future generations in Drosophila and whether this is sex-specific. METHODS: We reared male larvae and adults of Drosophila under different food conditions and performed lifespan analyses in F2 generation. RESULTS: Grandsons of males which experienced starvation through larval stages were long-lived and grandsons of well fed larvae were short lived, in two Drosophila strains. In one strain, the nutritional effect on transgenerational longevity was transmitted through male line. Interestingly, we find that dietary restriction in adult males is the main nutritional condition affecting lifespan of grandsons. CONCLUSIONS: Our findings suggest that nutritional regulation of transgenerational longevity is evolutionarily conserved and developmental stage - dependent in Drosophila.

  18. Radiotherapy versus combined modality in early stages

    DEFF Research Database (Denmark)

    Specht, L.; Carde, P.; Mauch, P.

    1992-01-01

    metaanalysis of these trials indicate that we still do not definitively know whether or not the addition of prophylactic chemotherapy up front improves survival. Arguments in favour of the addition of chemotherapy up front are: that laparotomy may be avoided, that radiation fields and doses may perhaps......In early stage Hodgkin's disease the optimal choice of treatment for the individual patient is still an unresolved issue. So far, twenty-two randomized trials of radiotherapy alone versus radiotherapy plus combination chemotherapy have been carried out worldwide. The preliminary results of a global...... be reduced, and that the stress of experiencing a relapse is avoided in many patients. The major argument against the use of chemotherapy up front is: that by careful staging and selection of patients and by careful radiotherapy techniques the number of patients exposed to potentially toxic chemotherapy may...

  19. [Treatment of early stage Hodgkin disease

    DEFF Research Database (Denmark)

    Specht, Lena; Carde, P.; Mauch, P.

    1993-01-01

    indicate that we still do not definitively know whether or not the early addition of prophylactic chemotherapy improves survival. Arguments in favour of early chemotherapy are: that laparotomy may be avoided, that radiation fields and doses may perhaps be reduced, and that the stress of experiencing......In early stage Hodgkin's disease the optimal choice of treatment is still an unresolved issue. Twenty-two randomized trials of radiotherapy alone versus radiotherapy plus combination chemotherapy have been carried out world-wide. The preliminary results of a global meta-analysis of these trials...... a relapse is avoided in many patients. The major argument against early chemotherapy is: that by careful staging and selection of patients and by careful radiotherapy techniques the number of patients exposed to potentially toxic chemotherapy may be kept at a minimum. Recently, trials have been carried out...

  20. Condensate from a two-stage gasifier

    DEFF Research Database (Denmark)

    Bentzen, Jens Dall; Henriksen, Ulrik Birk; Hindsgaul, Claus

    2000-01-01

    Condensate, produced when gas from downdraft biomass gasifier is cooled, contains organic compounds that inhibit nitrifiers. Treatment with activated carbon removes most of the organics and makes the condensate far less inhibitory. The condensate from an optimised two-stage gasifier is so clean...... that the organic compounds and the inhibition effect are very low even before treatment with activated carbon. The moderate inhibition effect relates to a high content of ammonia in the condensate. The nitrifiers become tolerant to the condensate after a few weeks of exposure. The level of organic compounds...... and the level of inhibition are so low that condensate from the optimised two-stage gasifier can be led to the public sewer....

  1. Dental Age Estimation (DAE): Data management for tooth development stages including the third molar. Appropriate censoring of Stage H, the final stage of tooth development.

    Science.gov (United States)

    Roberts, Graham J; McDonald, Fraser; Andiappan, Manoharan; Lucas, Victoria S

    2015-11-01

    The final stage of dental development of third molars is usually helpful to indicate whether or not a subject is aged over 18 years. A complexity is that the final stage of development is unlimited in its upper border. Investigators usually select an inappropriate upper age limit or censor point for this tooth development stage. The literature was searched for appropriate data sets for dental age estimation and those that provided the count (n), the mean (x¯), and the standard deviation (sd) for each of the tooth development stages. The Demirjian G and Demirjian H were used for this study. Upper and lower limits of the Stage G and Stage H data were calculated limiting the data to plus or minus three standard deviations from the mean. The upper border of Stage H was limited by appropriate censoring at the maximum value for Stage G. The maximum age at attainment from published data, for Stage H, ranged from 22.60 years to 34.50 years. These data were explored to demonstrate how censoring provides an estimate for the correct maximum age for the final stage of Stage H as 21.64 years for UK Caucasians. This study shows that confining the data array of individual tooth developments stages to ± 3sd provides a reliable and logical way of censoring the data for tooth development stages with a Normal distribution of data. For Stage H this is inappropriate as it is unbounded in its upper limit. The use of a censored data array for Stage H using Percentile values is appropriate. This increases the reliability of using third molar Stage H alone to determine whether or not an individual is over 18 years old. For Stage H, individual ancestral groups should be censored using the same technique. Copyright © 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  2. Intravital Microscopy for Identifying Tumor Vessels in Patients With Stage IA-IV Melanoma That is Being Removed by Surgery

    Science.gov (United States)

    2017-06-05

    Recurrent Melanoma; Stage IA Skin Melanoma; Stage IB Skin Melanoma; Stage IIA Skin Melanoma; Stage IIB Skin Melanoma; Stage IIC Skin Melanoma; Stage IIIA Skin Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma; Stage IV Skin Melanoma

  3. Acceptance and Commitment Therapy in Improving Well-Being in Patients With Stage III-IV Cancer and Their Partners

    Science.gov (United States)

    2017-09-21

    Malignant Female Reproductive System Neoplasm; Malignant Hepatobiliary Neoplasm; Partner; Stage III Breast Cancer; Stage III Cervical Cancer; Stage III Colorectal Cancer; Stage III Lung Cancer; Stage III Prostate Cancer; Stage III Skin Melanoma; Stage III Uterine Corpus Cancer; Stage IIIA Breast Cancer; Stage IIIA Cervical Cancer; Stage IIIA Colorectal Cancer; Stage IIIA Lung Carcinoma; Stage IIIA Skin Melanoma; Stage IIIA Uterine Corpus Cancer; Stage IIIB Breast Cancer; Stage IIIB Cervical Cancer; Stage IIIB Colorectal Cancer; Stage IIIB Lung Carcinoma; Stage IIIB Skin Melanoma; Stage IIIB Uterine Corpus Cancer; Stage IIIC Breast Cancer; Stage IIIC Colorectal Cancer; Stage IIIC Skin Melanoma; Stage IIIC Uterine Corpus Cancer; Stage IV Breast Cancer; Stage IV Cervical Cancer; Stage IV Colorectal Cancer; Stage IV Lung Cancer; Stage IV Prostate Cancer; Stage IV Skin Melanoma; Stage IV Uterine Corpus Cancer; Stage IVA Cervical Cancer; Stage IVA Colorectal Cancer; Stage IVA Uterine Corpus Cancer; Stage IVB Cervical Cancer; Stage IVB Colorectal Cancer; Stage IVB Uterine Corpus Cancer

  4. Vitrification of Germinal Vesicle Stage Oocytes

    OpenAIRE

    ABE, Yasuyuki; AONO, Nobuya; Hara, Kenshiro; Matsumoto, Hiromichi; BAKHTIYARI, Mehrdad; Sasada, Hiroshi; Sato, Eimei

    2004-01-01

    In order to cryopreserve germinal vesicle (GV) stage oocytes, we first need to develop a novel container for keeping large quantities of GV oocytes, because of collecting them as cumulus oocytes complexes (COCs) that have bigger size and larger volume than oocytes themselves, and second modify a protocol for optimizing vitrification of them. In this mini-review, we describe our recent progress for attaining these objectives. When 65 bovine COCs having GV oocytes could be placed on a sheet of ...

  5. Automatic sleep staging using ear-EEG

    OpenAIRE

    Mikkelsen, Kaare B.; Villadsen, David Bov?; Otto, Marit; Kidmose, Preben

    2017-01-01

    Background Sleep and sleep quality assessment by means of sleep stage analysis is important for both scientific and clinical applications. Unfortunately, the presently preferred method, polysomnography (PSG), requires considerable expert assistance and significantly affects the sleep of the person under observation. A reliable, accurate and mobile alternative to the PSG would make sleep information much more readily available in a wide range of medical circumstances. New method Using an alrea...

  6. Enhancement Techniques for Data Warehouse Staging Area

    OpenAIRE

    Mahmoud El-Wessimy; Hoda M.O.Mokhtar; Osman Hegazy

    2013-01-01

    Poor performance can turn a successful data warehousing project into a failure. Consequently, several attempts have been made by various researchers to deal with the problem of scheduling the ExtractTransform-Load (ETL) process. In this paper we therefore present several approaches in the context of enhancing the data warehousing Extract, Transform and loading stages. We focus on enhancing the performance of extract and transform phases by proposing two algorithms that reduce the ...

  7. Single-Stage BAHA and Mastoid Obliteration

    OpenAIRE

    George, Ajith; Coulson, Chris; Ross, Elizabeth; De, Ranit

    2012-01-01

    A single-stage fitting of a bone-anchored hearing aid (BAHA) implant and abutment with mastoid obliteration both obviates the need for two separate procedures and utilises the BAHA soft tissue reduction in the mastoid obliteration. Such a procedure has good outcomes in terms of osseointegration and achieving a dry ear. We present a 6-patient case series report highlighting the technique of combined BAHA insertion and mastoid obliteration in six patients. All patients at twelve-month followup ...

  8. Semi-Supervised Two Stage Classification Technique.

    Science.gov (United States)

    1987-07-31

    resulting clusters are never closed loops but grow in an open -ended fashion, as a tree. Because the algorithm uses a minimum distance metric it generates...72 the algorithms for 28 textural features. Wiersma and Landgrebe (1976) review four of Haralick’s texture measures in closer detail: angular second...are unlike the texture for grassy open fields or moderately textured brush. Access of Second Stage textural infor- mation should alleviate

  9. Myth and Misguided Faith? Women's Experiences in a Literacy Program.

    Science.gov (United States)

    Rumann, Susan Marie; Chavez, Rudolfo Chavez

    2001-01-01

    Inductive analysis of the stories of five Mexican-American women in a literacy program resulted in a framework of myths or misperceptions that proceeds through stages of consciousness from magical to naive to critical. (Contains 41 references.) (SK)

  10. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Program Commission on Cancer National Accreditation Program for Breast Centers National Cancer Database National Accreditation Program for Rectal Cancer Oncology Medical Home Accreditation Program Stereotactic Breast Biopsy Accreditation Program Cancer Programs Staff Information Children's ...

  11. Clinical prognostic markers in stage IIIC melanoma.

    Science.gov (United States)

    Madu, Max F; Schopman, Jaap H H; Berger, Danique M S; Klop, Willem M C; Jóźwiak, Katarzyna; Wouters, Michel W J M; van der Hage, Jos A; van Akkooi, Alexander C J

    2017-08-01

    Although the EORTC 18071-trial has shown a clear survival benefit for adjuvant ipilimumab, accurately selecting patients for this toxic adjuvant therapy is important. We aimed to identify prognostic factors for death and disease recurrence in AJCC stage IIIC melanoma patients. Retrospective analysis of patients who underwent lymph node dissection (LND) for stage IIIC melanoma in our institution between 2000 and 2016. Baseline characteristics, melanoma-specific survival (MSS), and disease-free survival (DFS) were assessed, and prognostic factors for recurrence and survival were analyzed using uni- and multivariable analysis. A total of 205 patients were included. Median follow-up was 20 months (interquartile range 11-43 months), median MSS was 28 months, and median DFS was 11 months. Five-year MSS was 33% and 5-year DFS was 23%. N3 (≥4 involved lymph nodes) and extracapsular extension (ECE) carried an increased risk of disease recurrence after LND and death by melanoma. Patients with both N3 and ECE had virtually no long-term survival. Although survival for patients with stage IIIC is poor in general, patients with both N3 disease and ECE constitute the group with the worst prognosis and should be considered for adjuvant therapy with ipilimumab or any other future effective adjuvant therapy (study). © 2017 Wiley Periodicals, Inc.

  12. Multi Staged Gasification Systems - A New Approach

    Energy Technology Data Exchange (ETDEWEB)

    Huber, M.B.; Koidl, F.; Kreutner, G.; Giovannini, A. (MCI - Univ. of Applied Science for Environmental-, Process- and Biotechnology, A-6020 Innsbruck (Austria)); Kleinhappl, M.; Roschitz, C.; Hofbauer, H. (Austrian Bioeneregy Centre, Graz (Austria)); Gruber, F. (GE Jenbacher, Jenbach (Austria)); Krueger, J. (SynCraft Engineering, Schwaz (Austria))

    2008-10-15

    Multi-staged fixed bed (MFB) gasification systems represent one of the most promising and effective methods of transforming solid biomass into power and heat (CHP). The underlying magic of this gasification process is, that a clean producer gas suitable for gas engines at high cold-gas efficiency rates can be produced. These two attributes allow multi-staged gasification systems to minimize the efforts for gas cleaning, while maximizing the energy retrieval out of the biomass. Though already demonstrated in small-scale, MFB gasification becomes a challenge when thinking of commercial-sized plants above 150kW{sub el}. In such a dimension especially the pressure loss over the char bed and bulk instabilities become the major process obstacles. After years of investigation the MCI developed a new process pathway which allows avoiding these bottle necks while maintaining the advantages of MFB systems. The core of the new staged alignment is the combination of a partial-oxidation-accelerator with a floating-bed-reduction-reactor. The process has already achieved technical proof of concept during ongoing investigations at a 250 kW{sub th} pilot plant in Jenbach and will be upscaled to demonstration plant size as soon as sufficient long time experience is gained

  13. Hepatocellular carcinoma: early-stage management challenges

    Directory of Open Access Journals (Sweden)

    Erstad DJ

    2017-06-01

    Full Text Available Derek J Erstad,1 Kenneth K Tanabe2–4 1Department of Surgery, Massachusetts General Hospital, 2Harvard Medical School, 3Division of Surgical Oncology, 4Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, MA, USA Abstract: Hepatocellular carcinoma (HCC is a major cause of cancer death and is increasing in incidence. This review focuses on HCC surveillance and treatment of early-stage disease, which are essential to improving outcomes. Multiple societies have published HCC surveillance guidelines, but screening efforts have been limited by noncompliance and overall lack of testing for patients with undiagnosed chronic liver disease. Treatment of early-stage HCC has become increasingly complex due to expanding therapeutic options and better outcomes with established treatments. Surgical indications for HCC have broadened with improved preoperative liver testing, neoadjuvant therapy, portal vein embolization, and perioperative care. Advances in post-procedural monitoring have improved efficacies of transarterial chemoembolization and radiofrequency ablation, and novel therapies involving delivery of radiochemicals are being studied in small trials. Finally, advances in liver transplantation have allowed for expanded indications beyond Milan criteria with non-inferior outcomes. More clinical trials evaluating new therapies and multimodal regimens are necessary to help clinicians design better treatment algorithms and improve outcomes. Keywords: hepatocellular carcinoma, hepatitis, surveillance, Barcelona clinic liver cancer, staging, cirrhosis, hepatectomy, hepatic resection, locoregional therapy, radiofrequency ablation, transarterial chemoembolization, liver transplantation

  14. Exercise in Targeting Metabolic Dysregulation in Stage I-III Breast or Prostate Cancer Survivors

    Science.gov (United States)

    2017-09-12

    Cancer Survivor; No Evidence of Disease; Obesity; Overweight; Prostate Carcinoma; Sedentary Lifestyle; Stage I Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage III Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer

  15. Information and Analysis System Stages of Family Welfare in District Balong

    Directory of Open Access Journals (Sweden)

    Eka Arynda Ayu

    2017-05-01

    Full Text Available Badan Kependudukan dan Keluarga Berencana Nasional (BKKBN is a family that formed due to legal marriage, is able to meet the needs of the spiritual and the material that is decent, devoted to God Almighty, have a relationship that is harmonious and balanced between members and between families with the community and the environment. Every year the government to collect data on the status of a prosperous family stage where the purpose of the data collection is in the framework of development and poverty alleviation programs. Data collection process in the District Balong is still done manually so that the risk of error in determining the status of a family stage could happen. Information and analysis system of status stages of family welfare is designed to make web-based officers in the input data and determine the status of a prosperous family stages based on selected indicators of the sheet R/1/KS. Sample of data from Bulukidul village and sub-district village of Balong Ngraket 2014. Results of the system in the form of data reports the results of process steps and the results can be viewed in graphical form. Comparison chart to show the status of the highest percentage of poor welfare families stages. Instead lowest percentage shows the stages of a prosperous family able or rich. 

  16. Collaboration with Pharma Will Introduce Nanotechnologies in Early Stage Drug Development | FNLCR Staging

    Science.gov (United States)

    The Frederick National Lab has begun to assist several major pharmaceutical companies in adopting nanotechnologies in early stage drug development, when the approach is most efficient and cost-effective. For some time, the national lab’s Nanotechno

  17. Second-stage primary Caesarean deliveries: Are maternal ...

    African Journals Online (AJOL)

    those who had first-stage CSs, except for increased blood loss, blood-stained urine, prolonged operative times and postoperative fever for second- stage CSs. .... blood transfusion, seven in the second-stage and five in the first-stage group; the reason for .... on this topic, including the current one, are flawed; therefore, any.

  18. Hybrid staging of a Lysholm positive displacement engine with two Westinghouse two stage impulse Curtis turbines

    Energy Technology Data Exchange (ETDEWEB)

    Parker, D.A.

    1982-06-01

    The University of California at Berkeley has tested and modeled satisfactorly a hybrid staged Lysholm engine (positive displacement) with a two stage Curtis wheel turbine. The system operates in a stable manner over its operating range (0/1-3/1 water ratio, 120 psia input). Proposals are made for controlling interstage pressure with a partial admission turbine and volume expansion to control mass flow and pressure ratio for the Lysholm engine.

  19. The search of chemical oxidation stage of two stage pyrite and copper concentrate bioleaching technology

    OpenAIRE

    Scornyacov, A.; Petukhova, N.; Meftakhov, R.; V. Zorin

    2011-01-01

    The bioleaching stage of two-stage biochemical leaching technology of pyrite and copper concentrate consisted of bornite, chalcopyrite and chalcocite, by moderate thermophiles consortium was searched. It has been shown that at 45 oC the bioleaching of copper concentrate pre-treated by biogenic leaching solution seems to be near 1.7 times faster than the non-treated one. Though the similar chemical pre-treatment of pyrite doesnt show any significant increase of its bioleaching rate.

  20. The features of teaching methods of programming in the system of supplementary education in informatics and ICT

    Directory of Open Access Journals (Sweden)

    Наталья Геннадьевна Саблукова

    2010-06-01

    Full Text Available The model of formation of the rational contents of teaching to programming in described in the article in view of specificity of supplementary education and features of visual surroundings of programming. The realization of structure of the contents of training to programming is written stage by stage.

  1. Programming Algol

    CERN Document Server

    Malcolme-Lawes, D J

    2014-01-01

    Programming - ALGOL describes the basics of computer programming using Algol. Commands that could be added to Algol and could increase its scope are described, including multiplication and division and the use of brackets. The idea of labeling or naming a command is also explained, along with a command allowing two alternative results. Most of the important features of Algol syntax are discussed, and examples of compound statements (that is, sets of commands enclosed by a begin ... end command) are given.Comprised of 11 chapters, this book begins with an introduction to the digital computer an

  2. Programming Interactivity

    CERN Document Server

    Noble, Joshua

    2012-01-01

    Ready to create rich interactive experiences with your artwork, designs, or prototypes? This is the ideal place to start. With this hands-on guide, you'll explore several themes in interactive art and design-including 3D graphics, sound, physical interaction, computer vision, and geolocation-and learn the basic programming and electronics concepts you need to implement them. No previous experience is necessary. You'll get a complete introduction to three free tools created specifically for artists and designers: the Processing programming language, the Arduino microcontroller, and the openFr

  3. ICD programming

    OpenAIRE

    Biffi, Mauro

    2014-01-01

    Background: Appropriate ICD programming is the key to prevent inappropriate shock delivery, that is closely associated to a negative patients' outcome. Methods: Review of the literature on ICD therapy to generate ICD programmings that can be applied to the broad population of ICD and CRT-D carriers. Results: Arrhythmia detection should occur with a detection time ranging 9″–12″ in the VF zone, and 15″–60″ in the VT zone. Discriminator should be applied at least up to 200 bpm. ATP therap...

  4. Multi-stage fuel cell system method and apparatus

    Science.gov (United States)

    George, Thomas J.; Smith, William C.

    2000-01-01

    A high efficiency, multi-stage fuel cell system method and apparatus is provided. The fuel cell system is comprised of multiple fuel cell stages, whereby the temperatures of the fuel and oxidant gas streams and the percentage of fuel consumed in each stage are controlled to optimize fuel cell system efficiency. The stages are connected in a serial, flow-through arrangement such that the oxidant gas and fuel gas flowing through an upstream stage is conducted directly into the next adjacent downstream stage. The fuel cell stages are further arranged such that unspent fuel and oxidant laden gases too hot to continue within an upstream stage because of material constraints are conducted into a subsequent downstream stage which comprises a similar cell configuration, however, which is constructed from materials having a higher heat tolerance and designed to meet higher thermal demands. In addition, fuel is underutilized in each stage, resulting in a higher overall fuel cell system efficiency.

  5. CT staging of alveolar echinococcosis of the liver

    Energy Technology Data Exchange (ETDEWEB)

    Rozanes, I. [Dept. of Radiology, Istanbul Medical Faculty (Turkey); Acunas, B. [Dept. of Radiology, Istanbul Medical Faculty (Turkey); Emre, A. [Hepatobiliary Surgery Unit, Dept. of General Surgery, Istanbul Medical Faculty (Turkey); Alper, A. [Hepatobiliary Surgery Unit, Dept. of General Surgery, Istanbul Medical Faculty (Turkey); Sayi, I. [Dept. of Radiology, Istanbul Medical Faculty (Turkey); Minareci, Oe. [Dept. of Radiology, Istanbul Medical Faculty (Turkey); Acarli, K. [Hepatobiliary Surgery Unit, Dept. of General Surgery, Istanbul Medical Faculty (Turkey); Hazar, H. [Hepatobiliary Surgery Unit, Dept. of General Surgery, Istanbul Medical Faculty (Turkey); Ariogul, O. [Hepatobiliary Surgery Unit, Dept. of General Surgery, Istanbul Medical Faculty (Turkey)

    1995-11-01

    The purpose of this study was to assess the usefulness of a new staging scheme for alveolar echinococcosis of the liver. A total of 28 patients with hepatic alveolar echinococcosis underwent CT examinations and were staged according to the proposed staging scheme (stage 1: lesion measuring less than 3 cm in diameter; stage 2: lesion greater than 3 cm, confined to less than three hepatic segments; stage 3a: lesion with invasion of more than three hepatic segments; stage 3b: invasion of liver hilum or suprahepatic vena cava; stage 4: invasion of surrounding organs and/or distant metastasis). Of the patients 16 underwent laparotomy, and results of the radiologic staging were correlated with surgical data. The CT findings correlated well with surgical findings. Patients were followed-up for a period of 6 months to 7 years. We concluded that the proposed staging scheme seemed to be useful for the therapeutic planning of patients with alveolar echinococcosis of the liver. (orig.)

  6. Validation and ranking of seven staging systems of hepatocellular carcinoma.

    Science.gov (United States)

    Chen, Zhan-Hong; Hong, Ying-Fen; Lin, Jinxiang; Li, Xing; Wu, Dong-Hao; Wen, Jing-Yun; Chen, Jie; Ruan, Dan-Yun; Lin, Qu; Dong, Min; Wei, Li; Wang, Tian-Tian; Lin, Ze-Xiao; Ma, Xiao-Kun; Wu, Xiang-Yuan; Xu, Ruihua

    2017-07-01

    The aim of the present study was to evaluate the ability of seven staging systems to predict 3- and 6-month and cumulative survival rates of patients with advanced hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). Data were collected from 220 patients with HBV-associated HCC who did not receive any standard anticancer treatment. Participants were patients at The Third Affiliated Hospital of Sun Yat-sen University from September 2008 to June 2010. The participants were classified according to the Chinese University Prognostic Index (CUPI), the Cancer of the Liver Italian Program (CLIP), Japan Integrated Staging (JIS), China Integrated Score (CIS) systems, Barcelona Clinic Liver Cancer (BCLC), Okuda and tumor-node-metastasis (TNM) staging systems at the time of diagnosis and during patient follow-up. The sensitivity and specificity of the predictive value of each staging system for 3- and 6-month mortality were analyzed by relative operating characteristic (ROC) curve analysis with a non-parametric test being used to compare the area under curve (AUC) of the ROC curves. In addition, log-rank tests and Kaplan-Meier estimator survival curves were applied to compare the overall survival rates of the patients with HCC defined as advanced using the various staging systems, and the Akaike information criterion (AIC) and likelihood ratio tests (LRTs) were used to evaluate the predictive value for overall survival in patients with advanced HCC. Using univariate and multivariate Cox's model analyses, the factors predictive of survival were also identified. A total of 220 patients with HBV-associated HCC were analyzed. Independent prognostic factors identified by multivariate analyses included tumor size, α-fetoprotein levels, blood urea nitrogen levels, the presence or absence of portal vein thrombus, Child-Pugh score and neutrophil count. When predicting 3-month survival, the AUCs of CLIP, CIS, CUPI, Okuda, TNM, JIS and BCLC were 0.806, 0.772, 0.751, 0

  7. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Safety Conference Registry Login SCR Training and Testing Cancer Cancer Programs Cancer Programs Overview of Cancer Programs Cancer Programs News American Joint Committee on ...

  8. Programming of Urban Revitalization

    Science.gov (United States)

    Biliński, Tadeusz

    2016-12-01

    The planning stage of the investment-construction process is of a crucial importance. Its overall impact on the costs, construction time and the quality of design solutions is huge. However, in practice, little attention is given to this pre-design stage, except for public buildings or other buildings of particular importance. In consequence, the results of investment and construction activities are unsatisfactory. Therefore, the issue has been given careful consideration in this paper. The paper discusses the issue of programming urban revitalization, emphasizing its socio-economic importance. To illustrate the complexity of revitalization projects planning, the author draws attention to social, economic, technical and organisational factors, such as public participation, reorganization and revaluation of land use planning, rationalization of energy use, organization and management of revitalization processes, as well as technical progress. Summarising the paper, the author concludes that in order to improve the quality of life of town residents and to protect material national heritage, it is indispensable to continuously revitalize subsequent town areas.

  9. Input Stage for Low-Voltage, Low-Noise Preamplifiers Based on a Floating-Gate MOS Transistor

    DEFF Research Database (Denmark)

    Igor, Mucha

    1997-01-01

    degradation of the performance of the circuit and without the need for a repeating programming. In this way the noise originating from any resistance previously used for the definition of the operating point is avoided completely and, moreover, by avoiding the input high-pass filter both the saturation......A novel input stage for low-voltage, low-noise preamplifiers for integrated capacitive sensors is presented. The input stage of the preamplifier employs floating-gate MOS transistors which are capable of storing the operation point of the input stage over several years without any severe...... of the input stage is abolished and very-low-frequency signal can be handled. A preamplifier using the proposed input stage, optimized for lowest white noise operation has been fabricated in a 0.8 micron CMOS process. The circuit operates with a power supply of 1.5V and consumes only a little bias current....

  10. Interconnected levels of multi-stage marketing: A triadic approach

    OpenAIRE

    Vedel, Mette; Geersbro, Jens; Ritter, Thomas

    2012-01-01

    Multi-stage marketing gains increasing attention as knowledge of and influence on the customer's customer become more critical for the firm's success. Despite this increasing managerial relevance, systematic approaches for analyzing multi-stage marketing are still missing. This paper conceptualizes different levels of multi-stage marketing and illustrates these stages with a case study. In addition, a triadic perspective is introduced as an analytical tool for multi-stage marketing research. ...

  11. Economic Gardening and the Grow Kentucky Program

    OpenAIRE

    Robbins, Lynn W.; Allen, James E. IV

    2015-01-01

    In 2014, the Community and Economic Development Initiative of Kentucky (CEDIK) and the Kentucky Small Business Development Center (KSBDC), launched Grow Kentucky, Kentucky’s only certified Economic Gardening program. The program helps second-stage entrepreneurial growth companies penetrate existing markets, identify new markets, monitor competitors, track industry trends, locate customer clusters, use search engine optimization/social media for marketing and various other customized research....

  12. Human Research Program 2010 Chair Standing Review Panel Meeting

    Science.gov (United States)

    Steinberg, Susan

    2011-01-01

    The 13 Human Research Program (HRP) Standing Review Panel (SRP) Chairs, and in some cases one or two additional panel members (see section XIV, roster) referred to as the Chair (+1) SRP throughout this document, met at the NASA Johnson Space Center (JSC) on December 7, 2010 to allow the HRP Elements and Projects to report on their progress over the past year, their current status, and their plans for the upcoming year based on NASA's current goals and objectives for human space exploration. A large focus of the meeting was also used to discuss integration across the HRP scientific disciplines based on a recommendation from the 2009 HRP SRP review. During the one-day meeting, each of the HRP Elements and Projects presented the changes they made to the HRP Integrated Research Plan (IRP Rev. B) over the last year, and what their top three areas of integration are between other HRP Elements/Projects. The Chair (+1) SRP spent sufficient time addressing the panel charge, either as a group or in a separate closed session, and the Chair (+1) SRP and the HRP presenters and observers, in most cases, had sufficient time to discuss during and after the presentations. The SRP made a final debriefing to the HRP Program Scientist, Dr. John B. Charles, prior to the close of the meeting on December 7, 2010. Overall, the Chair (+1) SRP concluded that most of the HRP Elements/Projects did a commendable job during the past year in addressing integration across the HRP scientific disciplines with the available resources. The Chair (+1) SRP agreed that the idea of integration between HRP Elements/Projects is noble, but believes all parties involved should have the same definition of integration, in order to be successful. The Chair (+1) SRP also believes that a key to successful integration is communication among the HRP Elements/Projects which may present a challenge. The Chair (+1) SRP recommends that the HRP have a workshop on program integration (with HRP Element

  13. Patient acceptance of osteoporosis treatment: Application of the stages of change model.

    Science.gov (United States)

    Sujic, R; Beaton, D E; Bogoch, E R

    2016-06-01

    To examine whether a commonly used model of behaviour change, stages of change, is helpful in understanding osteoporosis treatment initiation in a cohort of fragility fracture patients. This longitudinal cohort study used data from a provincial osteoporosis screening program targeting fragility fracture patients age 50 and over. Logistic regression was used to identify baseline factors associated with patients moving from the first, pre-contemplation stage at baseline to the more advanced stages of action/maintenance at follow-up, when treatment is initiated and maintained. Patient's stage-of-change readiness to accept osteoporosis treatment. At baseline, 91% of patients were in the pre-contemplation stage. Of these, 74.1% remained at the same stage at follow-up, 2.7% moved to contemplation and preparation while 23.2% moved to action/maintenance. The adjusted analysis showed that those who moved from pre-contemplation to action/maintenance were more likely to have a previous fracture OR 1.5 (1.1-2.0), history of oral steroid use OR 2.1 (1.3-3.5), higher perceived benefits to osteoporosis drug treatment OR 1.2 (1.0-1.3), perception of bones as "thin" OR 2.8 (2.0-4.0) and were less likely to perceive that they were taking too many medications OR 0.6 (0.5-0.9). With the majority of patients in the pre-contemplation and the action/maintenance stages, our results suggest an existence of a two-stage model. The baseline factors that we identified can be used to predict which patients are less likely to initiate treatment, which in turn, can be used to inform post-fracture interventions and facilitate behaviour change. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  14. Program Proposal

    Science.gov (United States)

    Baskas, Richard S.

    2012-01-01

    A study was conducted to determine if a deficiency, or learning gap, existed in a particular working environment. To determine if an assessment was to be conducted, a program proposal would need to be developed to explore this situation. In order for a particular environment to react and grow with other environments, it must be able to take on…

  15. Sprego Programming

    Directory of Open Access Journals (Sweden)

    Maria Csernoch

    2015-02-01

    Full Text Available Spreadsheet management is a border-land between office applications and programming, however, it is rather communicated that spreadsheet is nothing more than an easily handled fun piece. Consequently, the complexity of spreadsheet handling, the unprepared end-users, their problem solving abilities and approaches do not match. To overcome these problems we have developed and introduced Sprego (Spreadsheet Lego. Sprego is a simplified functional programming language in spreadsheet environment, and such as can be used both as introductory language and the language of end-user programmers. The essence of Sprego is that we use as few and simple functions as possible and based on these functions build multilevel formulas. With this approach, similar to high level programming, we are able solve advanced problems, developing algorithmic skills, computational thinking. The advantage of Sprego is the simplicity of the language, when the emphasis is not on the coding but on the problem. Beyond that spreadsheets would provide real life problems with authentic data and tables which students are more interested in than the artificial environment and semi-authentic problems of high level programming languages.

  16. Two-stage dental implants inserted in a one-stage procedure : a prospective comparative clinical study

    NARCIS (Netherlands)

    Heijdenrijk, Kees

    2002-01-01

    The results of this study indicate that dental implants designed for a submerged implantation procedure can be used in a single-stage procedure and may be as predictable as one-stage implants. Although one-stage implant systems and two-stage.

  17. The US Muon Accelerator Program

    Energy Technology Data Exchange (ETDEWEB)

    Torun, Y.; /IIT, Chicago; Kirk, H.; /Brookhaven; Bross, A.; Geer, Steve; Shiltsev, Vladimir; /Fermilab; Zisman, M.; /LBL, Berkeley

    2010-05-01

    An accelerator complex that can produce ultra-intense beams of muons presents many opportunities to explore new physics. A facility of this type is unique in that, in a relatively straightforward way, it can present a physics program that can be staged and thus move forward incrementally, addressing exciting new physics at each step. At the request of the US Department of Energy's Office of High Energy Physics, the Neutrino Factory and Muon Collider Collaboration (NFMCC) and the Fermilab Muon Collider Task Force (MCTF) have recently submitted a proposal to create a Muon Accelerator Program that will have, as a primary goal, to deliver a Design Feasibility Study for an energy-frontier Muon Collider by the end of a 7 year R&D program. This paper presents a description of a Muon Collider facility and gives an overview of the proposal.

  18. [Cost analysis of the colorectal neoplasm screen program in Beijing].

    Science.gov (United States)

    Mao, Ayan; Dong, Pei; Yan, Xiaoling; Hu, Guangyu; Chen, Qingkun; Qiu, Wuqi

    2015-05-01

    To conduct with a cost analysis of the colorectal neoplasm screening program in Beijing, and provide data evidence for decision making. Based on stratified cluster sampling method, we carried out a 2-stage colorectal neoplasm screening program within 6 districts, Dongcheng, Xicheng, Chaoyang, Haidian, Fengtai and Shijingshan, of Beijing city between October, 2012 to May. 2013. The first stage of the program was to conducting a cancer risk level evaluation for community residents who were forty years older and the second stage's task was to providing clinical exam for those high risk people who were selected from the first stage. There were about 12 953 residents were involved in this program. We calculated the main cost of the colorectal neoplasm screen program in Beijing. Then estimate the cost of detecting one Colorectal Neoplasm patient of this program and compare it with the total treatment cost for a patient. 2 487 high risk residents were selected by the first stage and 1 055 of them made appointment for the colonoscopy exam but only 375 accepted the exam, participate rate was 35.5%. 9 neoplasm cancer patients and 71 pre-cancer patient were found at the second stage, the detection rate were 69.2/100 000 and 546/100 000, respectively. The direct input for this neoplasm screening program was 227 100 CNY and the transport expense was 4 200 CNY in the calculations. The cost for detecting one cancer patient was about 19 900 CNY. Comparing with the total medical care cost of a cancer patient (1 282 800 CNY), especially for those have been diagnosed as middle to end stage cancer, the screening program (cost 842 800 CNY) might help to reduce the total health expenditure about 128 700 CNY, based on 12 953 local residents age above 40 years old. An colonoscopy based colorectal neoplasm screening program showed its function on medical expenditure saving and might have advantage on health social labor creating.

  19. Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097, Paclitaxel, and Carboplatin Before Surgery in Treating Patients With Stage II or Stage III Triple-Negative Breast Cancer

    Science.gov (United States)

    2015-09-03

    Estrogen Receptor Negative; HER2/Neu Negative; Progesterone Receptor Negative; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Triple-Negative Breast Carcinoma

  20. Omega-3 Fatty Acid in Treating Patients With Stage I-III Breast Cancer

    Science.gov (United States)

    2017-05-30

    Ductal Breast Carcinoma in Situ; Lobular Breast Carcinoma in Situ; Male Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer

  1. Prospective Cohort Study Depending on the Use of Palliative Care for Advanced Stage of Cancer Patients

    Science.gov (United States)

    2017-09-05

    Stage IV Breast Cancer; Stage IV Pancreatic Cancer; Stage IV Colon Cancer; Stage IV Gastric Cancer; Stage IV Lung Cancer; Stage IV Liver Cancer; Malignant Hematologic Neoplasm; Biliary Cancer Metastatic; Pediatric Leukemia; Pediatric Lymphoma; Pediatric Brain Tumor; Pediatric Solid Tumor

  2. Single stage surgery for Blepharophimosis syndrome

    Science.gov (United States)

    Bhattacharjee, Kasturi; Bhattacharjee, Harsha; Kuri, Ganesh; Shah, Zeenat Tajmin; Deori, Nilutparna

    2012-01-01

    Purpose: The purpose of this study was to report the functional and cosmetic outcome of single stage surgical procedure for correction of the classic components of Blepharophimosis syndrome. Materials and Methods: We report a retrospective case file review of 11 patients with Blepharophimosis syndrome operated between July 2004 and April 2008. Each patient had undergone the correction of epicanthus inversus, telecanthus, palpebral phimosis, and bilateral ptosis as a single-stage surgical procedure. Patients were examined and photographed before and after surgery. The mean follow-up was 3 years (range 2-6 years). Results: A total of 11 patients (8 males, 3 females) with a mean age of 9 years (range 6--22 years) were reviewed. The surgical outcome was assessed both functionally and cosmetically. The mean preoperative visual acuity was 0.729 ± 0.316 SD and the mean postoperative visual acuity was 0.856 ± 0.277 SD (P <0.0428). There was a statistically significant decrease of astigmatism following ptosis correction (P<0.05), improvement of telecanthus (P<0.0001) in terms of IICD (inner intercanthal distance), and HPFL (horizontal palpebral fissure length) (P=0.019) along with improvement of the superior visual field. The mean preoperative and postoperative IICD was 3±0.33 SD and 2.418 ± 0.189 SD, respectively. There was also a significant postoperative improvement of ptosis (P< 0.01), as measured by IPFH (vertical interpalpebral fissure height). All the patients had a stable functional and cosmetic result after a mean follow-up period of 3 years. Conclusion: Single-stage surgical correction of the classic anomalies of Blepharophimosis syndrome provides stable and successful long-term results. PMID:22569380

  3. Single stage surgery for Blepharophimosis syndrome

    Directory of Open Access Journals (Sweden)

    Kasturi Bhattacharjee

    2012-01-01

    Full Text Available Purpose: The purpose of this study was to report the functional and cosmetic outcome of single stage surgical procedure for correction of the classic components of Blepharophimosis syndrome. Materials and Methods: We report a retrospective case file review of 11 patients with Blepharophimosis syndrome operated between July 2004 and April 2008. Each patient had undergone the correction of epicanthus inversus, telecanthus, palpebral phimosis, and bilateral ptosis as a single-stage surgical procedure. Patients were examined and photographed before and after surgery. The mean follow-up was 3 years (range 2-6 years. Results: A total of 11 patients (8 males, 3 females with a mean age of 9 years (range 6--22 years were reviewed. The surgical outcome was assessed both functionally and cosmetically. The mean preoperative visual acuity was 0.729 ± 0.316 SD and the mean postoperative visual acuity was 0.856 ± 0.277 SD (P <0.0428. There was a statistically significant decrease of astigmatism following ptosis correction (P<0.05, improvement of telecanthus (P<0.0001 in terms of IICD (inner intercanthal distance, and HPFL (horizontal palpebral fissure length (P=0.019 along with improvement of the superior visual field. The mean preoperative and postoperative IICD was 3±0.33 SD and 2.418 ± 0.189 SD, respectively. There was also a significant postoperative improvement of ptosis (P< 0.01, as measured by IPFH (vertical interpalpebral fissure height. All the patients had a stable functional and cosmetic result after a mean follow-up period of 3 years. Conclusion: Single-stage surgical correction of the classic anomalies of Blepharophimosis syndrome provides stable and successful long-term results.

  4. Two-stage microbial community experimental design.

    Science.gov (United States)

    Tickle, Timothy L; Segata, Nicola; Waldron, Levi; Weingart, Uri; Huttenhower, Curtis

    2013-12-01

    Microbial community samples can be efficiently surveyed in high throughput by sequencing markers such as the 16S ribosomal RNA gene. Often, a collection of samples is then selected for subsequent metagenomic, metabolomic or other follow-up. Two-stage study design has long been used in ecology but has not yet been studied in-depth for high-throughput microbial community investigations. To avoid ad hoc sample selection, we developed and validated several purposive sample selection methods for two-stage studies (that is, biological criteria) targeting differing types of microbial communities. These methods select follow-up samples from large community surveys, with criteria including samples typical of the initially surveyed population, targeting specific microbial clades or rare species, maximizing diversity, representing extreme or deviant communities, or identifying communities distinct or discriminating among environment or host phenotypes. The accuracies of each sampling technique and their influences on the characteristics of the resulting selected microbial community were evaluated using both simulated and experimental data. Specifically, all criteria were able to identify samples whose properties were accurately retained in 318 paired 16S amplicon and whole-community metagenomic (follow-up) samples from the Human Microbiome Project. Some selection criteria resulted in follow-up samples that were strongly non-representative of the original survey population; diversity maximization particularly undersampled community configurations. Only selection of intentionally representative samples minimized differences in the selected sample set from the original microbial survey. An implementation is provided as the microPITA (Microbiomes: Picking Interesting Taxa for Analysis) software for two-stage study design of microbial communities.

  5. A Two-Stage Approach for Medical Supplies Intermodal Transportation in Large-Scale Disaster Responses

    Science.gov (United States)

    Ruan, Junhu; Wang, Xuping; Shi, Yan

    2014-01-01

    We present a two-stage approach for the “helicopters and vehicles” intermodal transportation of medical supplies in large-scale disaster responses. In the first stage, a fuzzy-based method and its heuristic algorithm are developed to select the locations of temporary distribution centers (TDCs) and assign medial aid points (MAPs) to each TDC. In the second stage, an integer-programming model is developed to determine the delivery routes. Numerical experiments verified the effectiveness of the approach, and observed several findings: (i) More TDCs often increase the efficiency and utility of medical supplies; (ii) It is not definitely true that vehicles should load more and more medical supplies in emergency responses; (iii) The more contrasting the traveling speeds of helicopters and vehicles are, the more advantageous the intermodal transportation is. PMID:25350005

  6. Patient compliance for postoperative radiotherapy and survival outcome of women with stage I endometrioid endometrial cancer.

    Science.gov (United States)

    Matsuo, Koji; Machida, Hiroko; Ragab, Omar M; Garcia-Sayre, Jocelyn; Yessaian, Annie A; Roman, Lynda D

    2017-09-01

    To examine characteristics and survival outcome of women with endometrial cancer who declined postoperative radiotherapy. A retrospective study was conducted to examine surgically-treated grade 1-2 stage IB and grade 3 stage IA-IB endometrioid endometrial cancer in the Surveillance, Epidemiology, and End Results Program between 1983 and 2013 (n = 10 613). Associations of patient declination for guideline-based postoperative radiotherapy and clinico-pathological demographics or survival outcome were examined on multivariable analysis. There were 323 (3.0%) women who declined adjuvant radiotherapy. Women who declined postoperative radiotherapy were more likely to be older, White, Western U.S. residents, and register in recent years (all, adjusted-P compliance to guideline-based postoperative radiotherapy is a prognostic factor for women with stage I endometrioid endometrial cancer. © 2017 Wiley Periodicals, Inc.

  7. A Two-Stage Approach for Medical Supplies Intermodal Transportation in Large-Scale Disaster Responses

    Directory of Open Access Journals (Sweden)

    Junhu Ruan

    2014-10-01

    Full Text Available We present a two-stage approach for the “helicopters and vehicles” intermodal transportation of medical supplies in large-scale disaster responses. In the first stage, a fuzzy-based method and its heuristic algorithm are developed to select the locations of temporary distribution centers (TDCs and assign medial aid points (MAPs to each TDC. In the second stage, an integer-programming model is developed to determine the delivery routes. Numerical experiments verified the effectiveness of the approach, and observed several findings: (i More TDCs often increase the efficiency and utility of medical supplies; (ii It is not definitely true that vehicles should load more and more medical supplies in emergency responses; (iii The more contrasting the traveling speeds of helicopters and vehicles are, the more advantageous the intermodal transportation is.

  8. Catalyst dispersion and activity under conditions of temperature-staged liquefaction. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Davis, A.; Schobert, H.H.; Mitchell, G.D.; Artok, L.

    1993-02-01

    This research program involves the investigation of the use of highly dispersed catalyst precursors for the pretreatment of coals by mild hydrogenation. During the course of this effort solvent preswelling of the coal was evaluated as a means of deeply impregnating catalysts into coal, active phases of catalysts under reaction conditions were studied and the impact of these techniques were evaluated during pretreatment and temperature-staged liquefaction. Two coals, a Texas subbituminous and a Utah high volatile A bituminous, were used to examine the effects of solvent swelling pretreatment and catalyst impregnation on conversion behavior at 275{degrees}C, representative of the first, low-temperature stage in a temperature-staged liquefaction reaction. Ferrous sulfate, iron pentacarbonyl, ammonium tetrathiomolybdate, and molybdenum hexacarbonyl were used as catalyst precursors. Without swelling pretreatment, impregnation of both coals increased conversion, mainly through increased yields of preasphaltenes.

  9. Catalyst dispersion and activity under conditions of temperature-staged liquefaction

    Energy Technology Data Exchange (ETDEWEB)

    Davis, A.; Schobert, H.H.; Mitchell, G.D.; Artok, L.

    1993-02-01

    This research program involves the investigation of the use of highly dispersed catalyst precursors for the pretreatment of coals by mild hydrogenation. During the course of this effort solvent preswelling of the coal was evaluated as a means of deeply impregnating catalysts into coal, active phases of catalysts under reaction conditions were studied and the impact of these techniques were evaluated during pretreatment and temperature-staged liquefaction. Two coals, a Texas subbituminous and a Utah high volatile A bituminous, were used to examine the effects of solvent swelling pretreatment and catalyst impregnation on conversion behavior at 275[degrees]C, representative of the first, low-temperature stage in a temperature-staged liquefaction reaction. Ferrous sulfate, iron pentacarbonyl, ammonium tetrathiomolybdate, and molybdenum hexacarbonyl were used as catalyst precursors. Without swelling pretreatment, impregnation of both coals increased conversion, mainly through increased yields of preasphaltenes.

  10. Epidemiology and staging of renal cell carcinoma.

    Science.gov (United States)

    Ridge, Carole A; Pua, Bradley B; Madoff, David C

    2014-03-01

    Incidence and mortality trends attributed to kidney cancer exhibit marked regional variability, likely related to demographic, environmental, and genetic factors. Efforts to identify reversible factors, which lead to the development of renal cell carcinoma (RCC), have led not only to a greater understanding of the etiology of RCC but also the genetic and histologic characteristics of renal tumors. This article describes this evolution by discussing contemporary RCC incidence and mortality data, the risk factors for development of RCC, the histologic features, and anatomic and integrated staging systems that guide treatment.

  11. Staging Events of Collaborative Design and Learning

    DEFF Research Database (Denmark)

    Binder, Thomas; Brandt, Eva; Horgen, Turid

    1998-01-01

    , and "rules of the game"-offers a promising perspective on concurrent engineering. With this as the starting point we report on the findings from a "walk-through" examination of the use of space in the R&D departments at the Danish company Danfoss. Moving from descriptive exploration to action research, we...... then present and discuss how we have taken part in developing what we believe to be supportive spatial and temporal environments for product development at two companies, Danfoss in Denmark and Xerox in the U.S. We end the paper by summing up what kinds of staging of events appear to be particularly productive...

  12. Stages in the economic globalization of tourism

    DEFF Research Database (Denmark)

    Hjalager, Anne Mette

    2007-01-01

    There is more to the globalization of tourism than cross-border flows of customers and purchasing power. This paper distinguishes four stages and different manifestations of the globalization of the tourism industry, and shows that it, like many other business systems, is undergoing an irrevocable...... globalizing process. Outsourcing, transnational ownership structures and investments, cross-border marketing collaborations, the purchase and sale of knowhow, and the free movement of labor are developments not confined to manufacturing alone, but are also highly relevant for the modernization of tourism...

  13. Evolutionary ecology of the prezygotic stage.

    Science.gov (United States)

    Bernasconi, G; Ashman, T-L; Birkhead, T R; Bishop, J D D; Grossniklaus, U; Kubli, E; Marshall, D L; Schmid, B; Skogsmyr, I; Snook, R R; Taylor, D; Till-Bottraud, I; Ward, P I; Zeh, D W; Hellriegel, B

    2004-02-13

    The life cycles of sexually reproducing animals and flowering plants begin with male and female gametes and their fusion to form a zygote. Selection at this earliest stage is crucial for offspring quality and raises similar evolutionary issues, yet zoology and botany use dissimilar approaches. There are striking parallels in the role of prezygotic competition for sexual selection on males, cryptic female choice, sexual conflict, and against selfish genetic elements and genetic incompatibility. In both groups, understanding the evolution of sex-specific and reproductive traits will require an appreciation of the effects of prezygotic competition on fitness.

  14. Getting Your Ducks in a Row: IT Governance, Risk, and Compliance Programs in Higher Education

    Science.gov (United States)

    Bichsel, Jacqueline; Feehan, Patrick

    2014-01-01

    Higher education IT governance, risk, and compliance (GRC) programs are in the development stage. Few institutions have all three programs in place, and many institutions are unclear where they should start when instituting or maturing their IT GRC programs. In addition, they are often uncertain as to whether GRC programs should be developed in…

  15. Market impacts of a multiyear mechanical fuel treatment program in the U.S.

    Science.gov (United States)

    Jeffrey P. Prestemon; Karen L. Abt; Robert J. Jr. Huggett

    2008-01-01

    We describe a two-stage model of global log and chip markets that evaluates the spatial and temporal economic effects of government- subsidized fire-related mechanical fuel treatment programs in the U.S.West and South. The first stage is a goal program that allocates subsidies according to fire risk and location priorities, given a budget and a feasible, market-...

  16. Intravital Microscopy in Evaluating Patients With Primary Peritoneal, Fallopian Tube, or Stage IA-IV Ovarian Cancer

    Science.gov (United States)

    2017-12-28

    Fallopian Tube Carcinoma; Primary Peritoneal Carcinoma; Stage I Ovarian Cancer; Stage IA Ovarian Cancer; Stage IB Ovarian Cancer; Stage IC Ovarian Cancer; Stage II Ovarian Cancer; Stage IIA Ovarian Cancer; Stage IIB Ovarian Cancer; Stage IIC Ovarian Cancer; Stage III Ovarian Cancer; Stage IIIA Ovarian Cancer; Stage IIIB Ovarian Cancer; Stage IIIC Ovarian Cancer; Stage IV Ovarian Cancer

  17. An investigation of football player movement skills at the stage of their sport improvement

    Directory of Open Access Journals (Sweden)

    Valeriy Marchenko

    2017-04-01

    Full Text Available Purpose: theoretical and experimental substantiation of methodology of improving movement skills football players of 16–18 years at the stage of sports perfection Material & Methods: theoretical analysis and generalization of experience of leading trainers and scientists, pedagogical observations, pedagogical experiment, pedagogical control testing, digital video, physiological, medical and biological and physiological methods, pedagogical programming method, mathematical methods of statistics. Results: implemented programming the movement activity of football players of 16-18 years at a stage of sports perfection. Conclusion the results showed both positive and negative trends in the course of the training process Using the method of pedagogical testing in the process of entrance control, in our opinion, is also effective, which was shown by the research.

  18. Racial/Ethnic, socioeconomic, and geographic disparities of cervical cancer advanced-stage diagnosis in Texas.

    Science.gov (United States)

    Zhan, F Benjamin; Lin, Yan

    2014-01-01

    Advanced-stage diagnosis is among the primary causes of mortality among cervical cancer patients. With the wide use of Pap smear screening, cervical cancer advanced-stage diagnosis rates have decreased. However, disparities of advanced-stage diagnosis persist among different population groups. A challenging task in cervical cancer disparity reduction is to identify where underserved population groups are. Based on cervical cancer incidence data between 1995 and 2008, this study investigated advanced-stage cervical cancer disparities in Texas from three social domains: Race/ethnicity, socioeconomic status (SES), and geographic location. Effects of individual and contextual factors, including age, tumor grade, race/ethnicity, as well as contextual SES, spatial access to health care, sociocultural factors, percentage of African Americans, and insurance expenditures, on these disparities were examined using multilevel logistic regressions. Significant variations by race/ethnicity and SES were found in cervical cancer advanced-stage diagnosis. We also found a decline in racial/ethnic disparities of advanced cervical cancer diagnosis rate from 1995 to 2008. However, the progress was slower among African Americans than Hispanics. Geographic disparities could be explained by age, race/ethnicity, SES, and the percentage of African Americans in a census tract. Our findings have important implications for developing effective cervical cancer screening and control programs. We identified the location of underserved populations who need the most assistance with cervical cancer screening. Cervical cancer intervention programs should target Hispanics and African Americans, as well as individuals from communities with lower SES in geographic areas where higher advanced-stage diagnosis rates were identified in this study. Copyright © 2014 Jacobs Institute of Women's Health. Published by Elsevier Inc. All rights reserved.

  19. Constraint Programming versus Mathematical Programming

    DEFF Research Database (Denmark)

    Hansen, Jesper

    2003-01-01

    Constraint Logic Programming (CLP) is a relatively new technique from the 80's with origins in Computer Science and Artificial Intelligence. Lately, much research have been focused on ways of using CLP within the paradigm of Operations Research (OR) and vice versa. The purpose of this paper...

  20. [Relationship between visual field index and visual field morphological stages of glaucoma and their diagnostic value].

    Science.gov (United States)

    Hou, X R; Qin, J Y; Ren, Z Q

    2017-02-11

    Objective: To investigate the rationality of visual field morphological stages of glaucoma, its relationship with visual field index and their diagnostic value. Methods: Retrospective series case study. Two hundred and seventy-four glaucoma patients and 100 normal control received visual field examination by Humphrey perimeter using standard automatic perimetry (SAP) program from March 2014 to September 2014. Glaucoma patients were graded into four stages according to characteristic morphological damage of visual field, distribution of mean defect (MD) and visual field index (VFI) of each stage were plotted and receiver operation characteristic curve (ROC) was used to explore its correlation with MD and VFI. The diagnostic value of MD and VFI was also compared. For the comparison of general data of subjects, categorical variables were compared using χ(2) test, numerical variables were compared using F test. MD and VFI were compared using ANOVA among stages according to visual field, followed by multiple comparisons using LSD method. The correlation between MD and VFI and different stages according to visual field defined their diagnostic value, and compared using area under the curve (AUC) of ROC. Results: No characteristic visual field damage was found in normal control group, and MD and VFI was (-0.06±1.24) dB and (99.15±0.76)%, respectively. Glaucomatous visual field damage was graded into early, medium, late and end stage according to morphological characteristic. MD for each stage were (-2.83±2.00) dB, (-9.70±3.68) dB, (-18.46±2.90) dB, and (-27.96±2.76) dB, respectively. VFI for each stage were (93.84±3.61)%, (75.16±10.85)%, (49.36±11.26)% and (17.65±10.59)%, respectively. MD and VFI of each stage of glaucomatous group and normal control group were all significantly different (F=1 165.53 and PAUC(MD) (P<0.05). Conclusions: It is feasible and rational of glaucomatous visual field damage to be graded into early, medium, late and end stage using